LOCUS 038_IIG_Bs27_020_SNP 3516674 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1en-cvskbtn VERSION urn.local...1en-cvskbtn KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3516564..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 226674..226679 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 226688 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="upshifts" promotor_-10 226694..226712 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 226728..226735 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 226750..226769 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 226750 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" /label="mpr CDS" gene 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /label="mpr gene" CDS 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" /label="ybfJ CDS" gene 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /label="ybfJ gene" promotor_-10 complement(227753..227767) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(227763) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(227783..227788) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 228046 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 228115..228122 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228137..228156 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 228150..228224 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 228150 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" CDS 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" /label="cesB CDS" gene 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /label="cesB gene" promotor_-35 228459..228466 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 228475 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 228480..228498 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 229116..229310 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 231082 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 231483..231492 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231501 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 231505..231520 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 232886 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 232952 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 232955..232974 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 233882..234025 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 233997..234004 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 234018..234037 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234027 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(234903..234921) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234920) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234937..234942) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 235046 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(235085) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(236363..236381) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236372) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236392..236400) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(236400..236418) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236416) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236434..236439) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(236490) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 238235..238254 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 238252 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 239112..239293 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(239140..239210) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(239199..239218) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(239214) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(239234..239241) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 239280..239287 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 239295 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 239300..239319 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 240031..240032 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240048..240062 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240058 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(240157..240175) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(240163) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(240190..240196) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 240366 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 240417..240421 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240437..240456 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240443 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 240454..240582 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 241642 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(241707) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(243103..243214) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(243187..243206) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(243214) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(243221..243228) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(244208..244227) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(244225) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(244242..244249) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(244314) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(246835..246852) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 246840..246859 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(246842) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 246846 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(246868..246875) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 249207 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 249327..249334 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 249339..249456 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 249339 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 249348..249367 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 254748..254755 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 254770..254787 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 254773 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 255455 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 255499 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 257140..257143 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 257158..257177 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 257170..257404 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 257170 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 258327..258334 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258349..258368 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258359 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 258598 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 258805..258905 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 258865 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 258953 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 259870..259889 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 259875..259943 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 259875 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(262123..263307) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 263276 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(263352) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(263748..263766) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263767) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263780..263786) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(263800..264798) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(263843) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 263979..263984 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 263998 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 264000..264018 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264012) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(264014..264028) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(264034) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(264036..264040) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 264443 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 264509..264515 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 264528..264547 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 264530 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(264772..264791) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264798) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264805..264812) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 265219 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 265511..265517 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 265524..265541 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 265535 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(265632..265647) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(265638) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(265660..265669) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 267555..267614 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(267623) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(269002..269021) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 269015..269021 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(269016) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(269036..269040) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 269036..269055 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 269038 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(269412) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(269415..269434) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269450..269454) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 270172 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(270227) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(272303..272322) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(272317) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(272337..272344) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 272419..272425 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272441..272458 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272447 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 273582 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 273706..273712 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273726..273745 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273726 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 274396 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 274441..275031 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(274472) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(274645,274647) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(274861..274880) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(274868) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(274894..274901) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 275003..275006 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275022..275041 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 275033 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 276136 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(276210) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(277876..277895) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(277882) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(277911..277914) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 277932..277935 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 277951..277970 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 277961 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 279948..279956 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 279968..279986 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 279968 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(281006) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(282070..282260) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(282245..282264) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282265) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282279..282286) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(283858..283876) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(283866) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(283890..283897) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 283922..284001 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 283922 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 283924..283930 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 283945..283962 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 285364..285944 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(285875..285956) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 285946 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(285948..285967) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 285949..285968 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(285957) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 287112 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 287159..287165 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 287180..287198 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 287183 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(287232) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 288966..289066 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 289026 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 289092 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 289708 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 289802..289809 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 289825..289844 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 289831 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 290454..290460 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290474..290493 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290478 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 290830 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 292396 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 293398..293405 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 293420..293439 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 293426..293628 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 293426 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(293474..293493) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293482) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(293508..293515) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 293612..293621 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 293630..293725 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 293630 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 293634..293649 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 296352 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 299144 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 299224..299231 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 299246..299265 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 299254 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 300474 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(300762) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(302016) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(302273..302292) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302292) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(302306..302312) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 302539..302558 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 302539 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(302588) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 305548 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(305580) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(305624) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(306757..306844) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 306812..306819 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(306831..306850) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 306834..306853 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(306844) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 306847 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(306863..306869) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 307644..307652 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307664..307682 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 307683 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 308321 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 308382..308389 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308404..308423 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308413 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 308849 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 308853..308857 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 309012..309019 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 309034..309053 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 309047..309184 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 309047 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 311178 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 311244..311251 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 311261 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 311265..311284 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 312344 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 313950 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(314026) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(314600..314700) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(314640) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 315560..315564 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315580..315599 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315594 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(315626..315645) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(315629) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(315660..315666) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 316133..316138 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316154..316172 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316164 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 316837..316846 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316860..316879 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316868 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(317296..317658) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 317654 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(319026..319037) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319036) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319052..319058) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 319078..319084 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319092 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319099..319110 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 319733..319740 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 319754..319854 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 319754..319773 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 319754 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(319850) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 320655 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(320730) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(321331..321350) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(321346) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(321365..321368) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(321374..321522) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 321424..321431 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 321444..321463 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 321446..321554 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 321448 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(321516..321534) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321522..321529 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321532) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321544..321563 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321550..321555) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321556 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 322129 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(322204) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(322973..322992) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 322974..322981 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(322979) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 322996..323015 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(323007..323012) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 323008 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 324034..324104 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 324520..324526 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324541..324552 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324548 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 325062..325140 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 325115..325120 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 325137..325155 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 325142 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 325892 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 325937..326064 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 326041..326045 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326060..326079 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326066 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 328017..328023 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328037..328056 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328045 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 328128..328134 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328147..328166 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328156 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 328592..328596 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 328594..328716 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 328596 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(329237..331092) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 330118 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 330163..330259 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 330230..330237 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 330252..330271 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 330261 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(331085..331103) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(331102) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(331117..331124) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(331510) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(331576) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(333361) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(333366..333379) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(333394..333402) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(334282..334301) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(334302) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(334316..334319) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 334353..334372 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(334353..334371) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 334360..334424 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 334361 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(334370) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(334387..334392) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 335436..337883 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(335471) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 337150..337155 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 337169..337173 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 337176 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(337208) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(337210..337229) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(337243..337250) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(339773..339792) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(339787) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(339804..339810) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(344343..344443) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(344383) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 344426..344433 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344447..344466 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344459 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 345694 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 345753..345759 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 345774..345793 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 345782 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 347332..347339 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 347353..347372 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 347363 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 348815 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 348860..350529 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(348878) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(350447..350466) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(350459) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(350461..353295) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(350481..350488) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 350498..350504 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350519..350537 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 350531..350753 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 350531 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 350722..350727 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350743..350761 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350755 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 351233 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 351281..351287 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 351294 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 351301..351312 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 351653 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 351758..351765 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 351781..351800 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 351785 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 353237 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(353691..353791) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(353731) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(354185..354204) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(354193) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(354195..354337) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(354218..354225) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 354350..354357 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 354368..357511 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 354368 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 354372..354391 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(354373..354473) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(354413) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(356083..356101) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(356098) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(356115..356122) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(356173) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(357391..357410) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(357406) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(357425..357428) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 357489..357492 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 357507..357526 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 357513 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 357945 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 358208..358211 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 358226..358245 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 358234..358534 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 358234 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 384665 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 384721..384728 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 384731 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 384740..384759 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 386004 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(386040..386140) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(386062) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(386080) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(386611..386630) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(386613) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(387613..387631) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(387620) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(387647..387652) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(389729..389748) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(389741) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(390483..390502) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(390486) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(390518..390522) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(390623..390774) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(390831) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(393078..393097) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393090) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393111..393118) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(393755..393773) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393762) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393788..393794) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 394071..394078 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(394086..394105) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 394092..394111 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394092) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 394100 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(394119..394126) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 396831 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 396857..396858 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 396858 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(397810) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 399307..399309 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399308..399327) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399318 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399326..399344 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399328) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(399330..>399513) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(399342..399349) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 399498..399507 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 399513..399514 /note_="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_011" downshifts 399519 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(399529..400968) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(399529..400968) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(399853..399864) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399859) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399878..399884) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(401011..401030) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 401012..401019 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(401018) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 401033..401052 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 401037 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(401041..401048) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 401075..402385 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 401075..402385 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 402263..402269 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 402283..402301 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 402291 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 402387..402394 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 402409..402428 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 402418 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 402454..403842 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 402454..403842 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 403850 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 403900..403906 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 403920..403931 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 403921 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 403965..404828 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 403965..404828 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 404848..405633 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 404848..405633 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 404953..404972 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 404953 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 405041 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 405635 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(405678..406292) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(405678..406292) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(405689) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(406305..407930) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(406305..407930) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(407965..408537) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(407965..408537) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(408559..408578) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(408574) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(408592..408599) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 408659..408678 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 408671 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 408702..409055 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 408702..409055 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 409026 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 409119..409126 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 409140..409159 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 409145 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 409155..409227 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 409228..410664 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 409228..410664 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 410689..411120 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 410689..411120 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 411122..412243 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 411122..412243 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 412226 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 412272..412275 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 412291..412310 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 412293 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 412334..413398 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 412334..413398 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 412568..412576 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 412590..412609 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 412600 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 413392 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 413465..413472 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413485..413504 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413498 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 413533..414096 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 413533..414096 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 414097..414821 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(414156..414764) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(414156..414764) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(414782..414801) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 414798..414804 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(414805) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 414817..414836 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 414823 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 414850..415242 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 414850..415242 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 415219 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(415275..415439) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(415275..415439) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(415295) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(415449..415467) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(415471) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(415482..415488) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 415501..415508 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 415522..415541 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 415525 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 415572..416321 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 415572..416321 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 416298 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(416374) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 416404..416410 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 416424..416443 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 416430..416526 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 416430 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 416527..417300 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 416527..417300 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 417315..418529 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 417315..418529 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 418553..419326 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 418553..419326 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 419371..420093 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 419371..420093 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 420096..421103 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 420096..421103 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 420589 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 420683..420783 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 420743 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 421119..421871 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 421119..421871 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 421869..421878 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421892..421911 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421902 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 421935..422576 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 421935..422576 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 422562 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(422574..422999) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(422619) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 422652..422658 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 422672..422691 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 422673 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 422749..422994 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 422749..422994 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 422995..423405 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(423000..423287) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(423000..423287) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(423308..423327) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(423324) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 423381..423385 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 423402..423421 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 423407 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 423438..425444 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 423438..425444 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 425445..425545 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 425546..426448 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 425546..426448 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 426428 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 426521..426528 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 426542..426561 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 426546..426633 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 426546 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 426634..428718 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 426634..428718 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 428705 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 428747..428753 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 428767..428785 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 428779 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 428790..428871 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 428833..428840 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 428854..428873 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 428873 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 428930..430441 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 428930..430441 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 430425 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(430461..431006) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(430461..431006) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(430494) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(431073..431091) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(431087) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(431106..431112) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 431148..431154 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 431166 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 431169..431187 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 431213..432073 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 431213..432073 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 432089..432592 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 432089..432592 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 432573 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 432621..432628 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432642..432661 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 432644 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 432678..433229 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 432678..433229 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 433244..433250 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 433265..433283 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 433278 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 433307..433729 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 433307..433729 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 433734..433742 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 433753..433772 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 433772..434138 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 433772 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(433798..433898) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(433833..434101) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(433833..434101) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(433838) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 434095 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 434175..434184 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 434197..434212 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 434202 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 434235..435044 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 434235..435044 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 435025 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(435088..435378) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(435088..435378) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(435092) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(435406..435425) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 435406..435424 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 435412 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(435422) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 435500..435507 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435521..435540 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435525 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 435563..435997 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 435563..435997 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 435994..435997 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 436006 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 436014..436033 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 436062..438245 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 436062..438245 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 438228 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 438294..438300 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 438315..438333 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 438316..438447 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 438316 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 438448..439536 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 438448..439536 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 439517..440368 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 439517..440368 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 440379..442088 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 440379..442088 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 442081..443343 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 442081..443343 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 443349..445460 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 443349..445460 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 445444 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 445557..445564 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445579..445598 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445586 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 445596..445739 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 445596..445739 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 445737 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 445782..445935 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 445936..447759 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 445936..447759 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 447751 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 447818..448267 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 447818..448267 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 448280..448286 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448301..448319 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 448302 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 448334..450058 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 448334..450058 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(449170..450029) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(450031..450142) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 450042 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(450050..450253) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(450050..450253) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(450074) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(450102..450202) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 450111..450116 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450133..450151 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(450142) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 450143..450358 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 450143 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(450209..450280) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(450252) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(450281..450547) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(450281..450547) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(450563..450582) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(450581) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(450594..450601) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(450651..451928) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(450651..451928) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(450670) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(451990..452009) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(452002) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(452004..452081) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(452022..452029) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(452065..452084) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(452081) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(452098..452107) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(452158..452415) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(452158..452415) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(452166) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(452232) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(452493..452945) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(452493..452945) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(452964..452982) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(452981) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(452996..453002) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 453014 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 453022..453041 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 453063..453881 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 453063..453881 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 453872 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 453949..453955 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 453969..453987 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 453977 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 454010..454381 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 454010..454381 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(454014) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 454398 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(454432) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(454435..454438) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 454460..454467 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 454479..454498 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454486 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 454513..454854 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 454513..454854 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 454848..455207 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 454848..455207 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(454910..455203) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 455148 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 455192 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(455244..456065) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(455244..456065) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(455248) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(456087..456105) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(456108) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(456119..456125) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(456150..457202) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(456150..457202) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 456462..456469 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 456484..457271 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 456484..456503 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456485 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(457215..457234) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(457220) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(457248..457255) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 457272..458879 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 457272..458879 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 458869..459549 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 458869..459549 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 459550..459624 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 459591..459598 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 459613..459630 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 459626 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 459670..460935 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 459670..460935 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 460928 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(460982) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 461019..461036 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 461021 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 461083..462135 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 461083..462135 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 462136..462379 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 462336 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 462412..463338 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 462412..463338 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 463358..464098 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 463358..464098 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 464157..464176 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 464162 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 464193..464528 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 464193..464528 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 464503 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 464548..464617 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 464583..464590 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 464604..464623 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 464618 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 464656..465801 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 464656..465801 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 465783 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(465826..466005) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(465826..466005) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(465844) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(465959..466123) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(465959..466123) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(466006..466174) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(466166..466185) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(466176) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(466200..466207) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 466315..466320 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 466336..466354 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 466340 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 466370..467242 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 466370..467242 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 466606..466615 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 466628..466643 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 466631 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(467187..467256) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(467230) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 467243..467592 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(467257..467577) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(467257..467577) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 467573..467577 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 467586..467600 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 467594..467751 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 467594 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(467598..467617) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(467613) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(467631..467638) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 467752..468816 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 467752..468816 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 468804 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 468888..470261 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 468888..470261 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 470292..470298 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470312..470323 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 470322 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 470365..470384 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 470366..470540 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 470366 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 470508..470515 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470530..470549 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 470542..470609 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 470542 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 470661..472145 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 470661..472145 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 472138 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 472258..472317 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 472258..472267 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 472260 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 472279..472294 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 472318..472797 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 472318..472797 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 472787..474268 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 472787..474268 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 474238 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 474283..474610 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(474292) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(474520..475119) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(474520..475119) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 474580..474585 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 474598..474617 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 474612..475213 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 474612 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(475143..475162) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(475154) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 475214..475579 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 475214..475579 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 475582..475587 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 475603..475744 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 475603..475621 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 475603 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 475745..476761 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 475745..476761 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 476746 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 476806..476813 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476827..476846 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476834 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 476876..478045 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 476876..478045 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 477974..477979 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 477994..478012 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478000 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 478075..478078 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 478094..478113 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478095 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 478161..478442 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 478161..478442 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 478447..478797 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 478447..478797 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(478587..479063) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(478630) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 478777 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 478831..478838 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 478852..478871 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478860 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 478912..479736 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 478912..479736 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(479046..479064) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479063) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(479065..479664) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(479078..479085) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(479653..479671) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479664) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(479666..480254) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(479685..479691) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 479741..480106 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 479741..480106 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 480110..480511 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 480110..480511 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(480252..480271) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(480269) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(480285..480294) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 480523..481530 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 480523..481530 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 481524..481530 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 481545..481563 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 481551 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 481592..481921 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 481592..481921 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 481918..482400 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 481918..482400 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 482366..483154 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 482366..483154 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 483154..483753 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 483154..483753 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 483739 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 483797..483803 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 483818..483837 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(483826,483828) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 483830 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 483864..483980 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 483864..483980 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 483996..484289 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 483996..484289 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 484257..484265 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 484277..484296 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 484286..484726 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 484286..484726 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 484292 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(484525..487580) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 484710..485153 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 484710..485153 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 485128 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 485184..485185 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 485201..485220 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 485201 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 485247..487406 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 485247..487406 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 487394..487413 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 487416..487632 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 487416 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(487416..487529) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(487416..487529) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(487569..487588) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(487586) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(487603..487611) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 487633..488085 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 487633..488085 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 488091..488097 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488112..488131 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 488120..488207 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 488120 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(488152) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 488208..488282 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 488208..488282 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 488287..488377 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 488287..488377 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 488407..488478 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 488407..488478 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 488490..488564 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 488490..488564 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 488591..488666 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 488591..488666 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 488678..488759 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 488678..488759 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 488824 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 488840..>488925 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 488840..>488925 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 488925..488926 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<488926..489232) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 488945 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(488977) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(489233..490252) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(489233..490252) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(489928..489947) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(489941) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(489962..489969) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 490041..490045 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 490062..490081 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 490066 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 490067..490511 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 490512..490922 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 490512..490922 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 490923..490992 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 490949 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(491045..491494) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(491045..491494) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 491609..492151 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 491609..492151 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 492624..492628 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492645..492664 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 492654 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 492704..493468 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 492704..493468 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 493662..494972 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 493662..494972 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 494995..495554 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 495555..495731 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 495555..495731 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 495756..496442 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 495756..496442 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 496784..496788 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 496803..496822 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 496811 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(496858,496860) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 496867..497052 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 496867..497052 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 497051 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 497402..497995 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 497402..497995 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 498108..498115 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 498129..498148 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 498140..498257 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 498140 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(498175) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 498258..498458 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 498258..498458 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(498356..499144) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 498361 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 498462 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(498526..498604) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(498526..498604) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(499145..499606) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(499145..499606) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 499615..500160 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(499658) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(499665..499684) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(499700..499707) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 500127 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(500174..500410) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(500174..500410) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(500508..501383) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(500508..501383) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 501496..502455 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 501496..502455 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(501517) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(501521..501540) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(502608..503480) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(502608..503480) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(503573..503578) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(503580..503581) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(503585) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 503654..503660 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 503668 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 503674..503693 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 503707..505095 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 503707..505095 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 505071 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 505205..506497 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 505205..506497 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 506506..506512 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506527..506546 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 506534 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 506545..506655 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 506656..507102 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 506656..507102 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 507131 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 507182..507189 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 507204..507223 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 507205 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 507339..507932 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 507339..507932 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 507975 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(508051) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 508064..508071 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 508085 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 508086..508105 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(508284..508943) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(508284..508943) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(508992..509011) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(508999) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(509023..509028) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(509365..510228) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(509365..510228) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 510271..510277 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510292..510311 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(510293..510312) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 510307 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(510317) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(510327..510334) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 510383..511774 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 510383..511774 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 511902..511909 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 511920..511939 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 511934 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 511968..512393 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 511968..512393 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 512394..513648 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(512446..513018) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(512446..513018) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(512451) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(513019..513099) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(513100..513429) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(513100..513429) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(513446..513465) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(513463) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 513637..513656 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 513650 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 513684..514556 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 513684..514556 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 514443 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 514641 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(514706..515092) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(514706..515092) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(514718) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(515093..515157) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 515145..515152 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(515146..515165) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(515159) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 515166..515185 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 515169 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(515180..515187) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 515203..515796 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 515203..515796 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(515940..517127) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(515940..517127) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 517263..517267 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 517281 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 517282..517301 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 517331..517927 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 517331..517927 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 518041..518226 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 518041..518226 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 518205 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 518338..518341 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 518348..518534 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 518348 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 518356..518375 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 518535..518870 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 518535..518870 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 518883..520190 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 518883..520190 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 520222..520326 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 520222..520326 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 520335..520448 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 520335..520448 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 520634..520642 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 520653..520671 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 520670 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 520688..521473 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 520688..521473 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 520735 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 521483 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(521530..522450) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(521530..522450) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 522583..524031 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 522583..524031 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(524149..524772) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(524149..524772) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(524796..524815) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 524804..524811 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(524815) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 524826..524845 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 524828 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(524830..524836) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 524862..525542 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 524862..525542 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 525575 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(525622..526065) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(525622..526065) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(525627) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(526088..526107) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(526112) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(526121..526128) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(526151..526330) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(526151..526330) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(526327..526470) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(526327..526470) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 526421..526423 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 526439..526458 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 526455 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 526738..527961 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 526738..527961 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 527954..528595 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 527954..528595 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 528589 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(528622..528641) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(528643) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(528655..528662) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 528703..528708 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 528711..530885 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 528711..530885 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 528721 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 528723..528741 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(529787..529805) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(529787) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(530889..531296) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 530906..530910 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 530920 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 530923..530942 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(530934) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(531297..532199) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(531297..532199) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(532200..532295) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(532275..532294) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(532295) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532308..532315) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(532401..533090) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(532401..533090) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(533180..533992) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(533180..533992) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(534021..534040) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(534034) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(534056..534063) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(534103..534996) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(534103..534996) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(534123) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(534997..535089) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(535070..535089) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(535087) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(535105..535112) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 535278..535285 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 535300..535319 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 535306 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 535472..536092 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 535472..536092 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 535816..535822 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 535827 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 535836..535854 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 536108..537046 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 536108..537046 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 537034..537037 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 537052..537071 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 537059..537147 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 537059 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 537148..537537 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 537148..537537 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 537528 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 537651..537670 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 537653..537722 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 537653 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 537723..538061 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 537723..538061 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 538049 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(538101..538337) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(538101..538337) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(538125) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 538149..538155 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 538170..538181 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 538181 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(538338..538499) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(538503..538868) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(538543) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(538869..539099) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(538869..539099) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 539083 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(539120..539139) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(539137) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(539139..539222) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(539153..539162) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(539223..539900) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(539223..539900) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(539871..539882) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(539885) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(539897..539903) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(539901..540734) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 539916..539921 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 539936..539947 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 539941 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 540013..540720 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 540013..540720 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(540735..541166) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(540735..541166) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(541179..541421) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(541179..541421) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(541435..541707) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(541435..541707) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(541729..541748) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(541733) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(541762..541771) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 541926..541933 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 541949..541968 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 541957 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 542006..542593 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 542006..542593 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 542590..542934 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 542590..542934 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 542935..543096 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 543097..543570 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 543097..543570 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 543571..544263 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(543713) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(543730..545373) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(543730..545373) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(545408..545605) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 545422..545424 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 545441..545459 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 545445 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(545451) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 545571 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(545597..545616) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(545609) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(545629..545636) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(545692) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(545693..547069) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(545693..547069) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(547119..547138) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(547134) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(547208,547210) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 547209..547242 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(547241..547759) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(547241..547759) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(547255) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(547785..547804) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(547804) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(547820..547823) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 547841..547848 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 547863..547882 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 547881 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS complement(547893..548294) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /locus_tag="BSU_05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /modified_by="User" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_BSU_05890_3'_ext" CDS complement(547893..548021) /locus_tag="PG10_rand_002" /created_by="User" /transl_table=11 /pseudo /translation="MYNHGNLITDLLDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_rand_002" gene complement(547893..548294) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /old_locus_tag="BSU_05890" /pseudo /modified_by="User" /label="PG10_BSU_05890_3'_ext" gene complement(547893..548021) /locus_tag="PG10_rand_002" /created_by="User" /label="PG10_rand_002" CDS 547911..548003 /locus_tag="PG10_rand_001" /created_by="User" /transl_table=11 /pseudo /translation="MRLIRAHFINSCFLQHTCRLKKQVIQQVSN*" /label="PG10_rand_001" gene 547911..548003 /locus_tag="PG10_rand_001" /created_by="User" /modified_by="User" /label="PG10_rand_001" SCAR 547913..547914 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs22" CDS complement(548225..548419) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(548225..548419) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(548452..548463) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(548460) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(548477..548483) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 548538..548545 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548559..548578 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 548561..548661 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 548563 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(548609) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 548621 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 548629..548636 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548650..548669 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 548665..548752 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 548665 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 548753..548829 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 548753..548829 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 548843..548916 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 548843..548916 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 549076..550630 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 549076..550630 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 550798..553725 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 550798..553725 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 553781..553897 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 553781..553897 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 553911..553987 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 553911..553987 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 554048..554124 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 554048..554124 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 554121 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 554225..554229 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 554245..554264 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 554249 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 554305..555282 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 554305..555282 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 555297..555773 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 555297..555773 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 555754..556443 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 555754..556443 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 556453..556908 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 556453..556908 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 556901..557941 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 556901..557941 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 557905 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(558171..560099) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(558171..560099) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(558188) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 559851..559870 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 559861 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 559863..560052 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 560017..560024 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 560038..560057 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 560054..560224 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 560054 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(560119..560138) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(560131) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(560152..560159) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 560225..560737 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 560225..560737 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 560734..561381 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 560734..561381 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 561211..561311 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 561271 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 561403..561576 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 561403..561576 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 561583..562347 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 561583..562347 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 562327 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(562385..562576) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(562385..562576) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(562402) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(562573..563307) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(562573..563307) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 562965..562970 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 562985..563003 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 562987 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 563306..563307 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 563317..563331 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 563339 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(563344..563363) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 563361..563469 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(563364) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(563377..563382) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 563443..563449 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 563463..563482 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 563471..563545 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 563471 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 563546..563830 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 563546..563830 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 563877..565511 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 563877..565511 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 565512..565604 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 565561 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(565599..565727) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(565599..565727) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 565606..>566832 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(565730..565888) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(565730..565888) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(565933..566061) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(565933..566061) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(566154..566363) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(566154..566363) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(566356..566661) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(566356..566661) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(566832,566839) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 566833..566838 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(566937..569426) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(566937..569426) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(566959) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(569440..569459) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(569466) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(569473..569480) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 569529..569530 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 569545..569627 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 569545 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 569546..569565 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 569628..570689 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 569628..570689 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 570763..572154 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 570763..572154 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 572181..572188 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 572202..572221 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 572207 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 572249..573211 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 572249..573211 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 573196 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 573336..573345 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 573352 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 573358..573373 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 573407..574090 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 573407..574090 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 574091..574155 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 574156..575181 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 574156..575181 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 575181..575945 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 575181..575945 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 575976..576947 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 575976..576947 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 576937 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 576981 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(576994..578019) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(576994..578019) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(578051..578070) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(578069) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(578084..578090) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 578279..578286 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 578299 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 578301..578603 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 578301..578320 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 578604..580025 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 578604..580025 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 580017 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(580073) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(580073..581113) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(580073..581113) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 580653..580662 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 580676..580695 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 580677..581212 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 580677 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(581114..581408) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 581213..581232 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 581214..581511 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 581214 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(581403..581417) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(581408) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 581510..581529 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 581513 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 581552..581923 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 581552..581923 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 581909 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 581989..583035 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 581989..583035 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 583009 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(583069..583227) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(583069..583227) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(583085) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(583284..583416) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(583327) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(583417..583626) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(583417..583626) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(583659..583678) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(583670) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(583709..584524) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(583709..584524) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 584351..584360 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 584373..584392 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 584373 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(584537..585526) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(584537..585526) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(585391..585409) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(585399) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(585425..585430) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(585548..585563) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(585569) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(585575..585584) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(585624..587165) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(585624..587165) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(585637) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(587196..587215) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(587210) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(587229..587238) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(587317..588726) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(587317..588726) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(587331) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(588764..589051) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(588764..589051) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(588767..588786) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(588781) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 589057..589064 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 589080..589099 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 589081 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 589124..589996 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 589124..589996 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 589961 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(590236) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 590290..590309 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 590300 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 590346..591308 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 590346..591308 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 591308..592504 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 591308..592504 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 592526..594739 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 592526..594739 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 594734..594741 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 594756..594775 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 594772..594901 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 594772 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 594902..596443 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 594902..596443 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 596429 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 596550..596554 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 596570..596589 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 596580 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 596587..596689 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 596587..596689 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 596715 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 596824..598146 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 596824..598146 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 598124 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 598167 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 598196..598205 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 598216..598356 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 598216 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 598218..598233 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 598357..599160 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 598357..599160 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 599145 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 599228..599235 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 599249..599268 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 599255..599318 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 599255 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 599319..599486 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 599319..599486 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 599493 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 599537..599543 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 599558..599576 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 599561..599647 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 599561 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 599626..599633 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 599647..599666 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 599649 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 599700..600254 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 599700..600254 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 600254..600451 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 600254..600451 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 600441 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 600497..600504 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 600519..600538 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 600521 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 600531..600633 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 600531..600633 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 600634..600773 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 600774..601262 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 600774..601262 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 601255..602397 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 601255..602397 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 602394..603689 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 602394..603689 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(602699..602718) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(602720) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(602733..602740) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 603763..604488 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 603763..604488 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 604481..604735 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 604481..604735 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 604732..605415 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 604732..605415 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 605399..607627 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 605399..607627 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(605647) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 607603..609033 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 607603..609033 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 609034..609134 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 609135..610175 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 609135..610175 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 610172..610759 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 610172..610759 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 610182..610196 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 610191 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(610458..610476) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(610465) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(610492..610497) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 610756..612294 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 610756..612294 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 612310..613578 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 612310..613578 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 613563 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(613618..614037) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(613618..614037) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(614107..614126) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(614116) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 614181..615455 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 614181..615455 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 615404 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(615470..615697) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(615470..615697) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(615481) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(615698..616118) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 615765..615770 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 615781 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 615784..615803 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 615826..617568 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 615826..617568 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(616103..616114) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(616118) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(616128..616134) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 616149 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 617542..617548 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 617560 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 617561..617580 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 617595..618590 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 617595..618590 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 618593..618907 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 618593..618907 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 618770 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 618912 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(618942..620519) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(618942..620519) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(618956) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(620533..620552) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(620552) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(620567..620573) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 620716..620719 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 620733 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 620736..620755 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 620784..621470 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 620784..621470 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 621532..623751 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 621532..623751 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 623775..625781 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 623775..625781 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 625797..626987 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 625797..626987 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(625992..625996) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(625996) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 627024..627043 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 627032..627148 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 627032 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(627096) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 627149..628159 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 627149..628159 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(627166..627266) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(627206) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 628142 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 628186..628990 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(628197..628895) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(628197..628895) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(628218) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(628915..628933) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(628936) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(628949..628954) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(629002..630480) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(629002..630480) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(629016) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(629868) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(629871..629884) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(630481..630611) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(630602..630620) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(630611) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(630635..630641) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 630742..630745 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 630760..630893 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 630760 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 630762..630781 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 630894..631184 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 630894..631184 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 631200..632657 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 631200..632657 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 632671..634101 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 632671..634101 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 634082 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(634116..634985) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(634116..634985) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(634158) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 634775..634780 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 634796..634814 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 634808 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(634986..635060) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 635038..635045 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(635054..635073) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 635060 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 635061..635080 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(635067) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(635088..635095) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 635117..638275 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 635117..638275 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 638262 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 638514..638517 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 638532..638551 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 638540 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 638598..639509 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 638598..639509 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 639510..639764 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 639765..641144 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 639765..641144 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" S_feature 641145..641737 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(641157..642059) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" /label="yefB CDS" gene complement(641157..642059) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /label="yefB gene" downshifts 641694 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 641739..642039 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 642040..642375 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" /label="yefC CDS" gene 642040..642375 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /label="yefC gene" S_feature 642376..642449 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 642450..645089 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" /label="yeeA CDS" gene 642450..645089 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /label="yeeA gene" CDS 645101..646900 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" /label="yeeB CDS" gene 645101..646900 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /label="yeeB gene" promotor_-10 complement(645341..645356) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(645356) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(645368..645377) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 646901..647012 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 647013..648161 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" /label="yeeC CDS" gene 647013..648161 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /label="yeeC gene" S_feature 648162..649351 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(648423..648728) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " /label="yeeD CDS" gene complement(648423..648728) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /label="yeeD gene" CDS complement(648795..649001) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" /label="yezA CDS" gene complement(648795..649001) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /label="yezA gene" CDS complement(649241..649696) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" /label="yezG CDS" gene complement(649241..649696) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /label="yezG gene" downshifts complement(649254) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" CDS complement(649716..651725) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" /label="yeeF CDS" gene complement(649716..651725) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /label="yeeF gene" promotor_-10 complement(650083..650102) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(650090) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(650115..650120) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(651752..651771) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(651762) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="upshifts" CDS 651937..652959 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" /label="yeeG CDS" gene 651937..652959 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /label="yeeG gene" promotor_-35 653059..653066 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 653080..653099 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 653081 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="upshifts" CDS 653121..654251 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" /label="rapH CDS" gene 653121..654251 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /label="rapH gene" CDS 654241..654414 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" /label="phrH CDS" gene 654241..654414 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /label="phrH gene" downshifts 654369 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" /label="downshifts" S_feature 654415..654519 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 654486..654493 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 654508..654527 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 654521 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="upshifts" CDS 654574..655293 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" /label="yeeI CDS" gene 654574..655293 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /label="yeeI gene" downshifts complement(654576) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" /label="downshifts" promotor_-35 655151..655158 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 655172..655191 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 655182 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" downshifts 655275 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 655362..655371 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 655385..655404 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 655388 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(655392..655410) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(655412) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(655426..655431) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 655427..655864 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" /label="cotK CDS" gene 655427..655864 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /label="cotK gene" downshifts complement(655434) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" /label="downshifts" downshifts 655864 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 655924..655931 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 655947..655966 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 655952 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="upshifts" CDS 655979..656563 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" /label="yezE CDS" gene 655979..656563 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /label="yezE gene" downshifts 656544 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 656642..657085 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" /label="yesE CDS" gene 656642..657085 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /label="yesE gene" CDS 657082..657942 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" /label="yesF CDS" gene 657082..657942 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /label="yesF gene" promotor_-35 658004..658009 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 658025..658043 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 658025 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(658047..658061) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(658052) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(658069..658073) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 658069..658317 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" /label="cotJA CDS" gene 658069..658317 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /label="cotJA gene" CDS 658301..658564 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" /label="cotJB CDS" gene 658301..658564 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /label="cotJB gene" CDS 658579..659148 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" /label="cotJC CDS" gene 658579..659148 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /label="cotJC gene" S_feature 659149..659227 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 659200..659205 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 659220..659239 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 659229 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="upshifts" CDS 659273..659815 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" /label="yesJ CDS" gene 659273..659815 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /label="yesJ gene" downshifts 659782 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS 659838..660140 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" /label="yesK CDS" gene 659838..660140 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /label="yesK gene" promotor_-35 660183..660191 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 660202..660220 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 660208 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="upshifts" CDS 660255..660884 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" /label="yesL CDS" gene 660255..660884 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /label="yesL gene" CDS 660881..662614 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" /label="yesM CDS" gene 660881..662614 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /label="yesM gene" CDS 662614..663720 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" /label="yesN CDS" gene 662614..663720 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /label="yesN gene" downshifts 663674 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" promotor_-35 663759..663762 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 663777..663796 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 663784 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 663824..665107 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" /label="yesO CDS" gene 663824..665107 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /label="yesO gene" CDS 665104..666033 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" /label="rhgP CDS" gene 665104..666033 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /label="rhgP gene" CDS 666037..666927 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" /label="rhgQ CDS" gene 666037..666927 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /label="rhgQ gene" CDS 666943..667977 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" /label="rhgH CDS" gene 666943..667977 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /label="rhgH gene" CDS 668000..670285 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" /label="rhgR CDS" gene 668000..670285 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /label="rhgR gene" CDS 670299..670997 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" /label="rhgT CDS" gene 670299..670997 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /label="rhgT gene" CDS 670990..671652 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" /label="yesU CDS" gene 670990..671652 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /label="yesU gene" CDS 671649..672275 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" /label="yesV CDS" gene 671649..672275 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /label="yesV gene" CDS 672396..674258 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" /label="rhgW CDS" gene 672396..674258 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /label="rhgW gene" promotor_no_box 672436..672536 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 672496 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(673034) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(673035..673054) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(673067..673076) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 674304..676142 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" /label="rhgX CDS" gene 674304..676142 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /label="rhgX gene" CDS 676300..676953 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " /label="yesY CDS" gene 676300..676953 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /label="yesY gene" CDS 676961..678952 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" /label="rhgZ CDS" gene 676961..678952 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /label="rhgZ gene" CDS 678996..681569 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" /label="yetA CDS" gene 678996..681569 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /label="yetA gene" promotor_-10 complement(680318..680336) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(680331) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(680352..680357) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 681691..683199 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" /label="lplA CDS" gene 681691..683199 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /label="lplA gene" CDS 683254..684210 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" /label="lplB CDS" gene 683254..684210 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /label="lplB gene" downshifts complement(683528) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(683554..683654) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(683594) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 684224..685111 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" /label="lplC CDS" gene 684224..685111 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /label="lplC gene" promotor_-35 684858..684863 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 684879..684897 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 684882 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="upshifts" CDS 685120..686460 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" /label="lplD CDS" gene 685120..686460 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /label="lplD gene" S_feature complement(685554..687245) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 686461..686542 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 686543..687238 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" /label="yetF CDS" gene 686543..687238 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /label="yetF gene" downshifts 687236 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(687275..687601) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" /label="hmoA CDS" gene complement(687275..687601) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /label="hmoA gene" downshifts complement(687290) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 687588 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(687624..687643) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(687642) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(687658..687665) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(687705..688067) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" /label="yetH CDS" gene complement(687705..688067) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /label="yetH gene" promotor_-10 complement(688090..688109) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(688104) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="upshifts" promotor_-35 complement(688122..688128) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(688138..688698) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(688170) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(688681..688700) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(688698) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(688714..688723) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 688786..688793 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 688802 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 688806..688825 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 688851..689432 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" /label="yetI CDS" gene 688851..689432 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo /label="yetI gene" CDS 689426..689722 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" /label="yetI CDS" gene 689426..689722 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo /label="yetI gene" downshifts 689714 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 689793..689800 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 689814..689833 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 689822 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 689877..690044 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" /label="yezD CDS" gene 689877..690044 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /label="yezD gene" promotor_-35 690086..690093 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 690109..690128 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 690110 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 690154..690798 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" /label="calJ CDS" gene 690154..690798 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /label="calJ gene" downshifts 690734 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" /label="downshifts" downshifts 690778 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" CDS 690798..691790 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" /label="yetK CDS" gene 690798..691790 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /label="yetK gene" downshifts 691724 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 691768 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(691814..692317) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" /label="flvL CDS" gene complement(691814..692317) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /label="flvL gene" promotor_-10 complement(692342..692361) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(692350) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(692375..692382) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 692480..693589 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" /label="flvM CDS" gene 692480..693589 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /label="flvM gene" downshifts 693572 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS complement(693624..694694) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" /label="yetN CDS" gene complement(693624..694694) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /label="yetN gene" downshifts complement(693648) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(694725..694744) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(694751) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(694759..694766) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 694774..694780 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 694795..694813 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 694804 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="upshifts" CDS 694844..698029 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" /label="cypD CDS" gene 694844..698029 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /label="cypD gene" downshifts 698016 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 698079..698084 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 698100..698118 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 698121 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 698149..698152 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 698169..698188 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 698170..698475 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 698170 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 698476..700395 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 698476..700395 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 700394 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 700483..700492 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 700502..700630 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 700502 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 700506..700525 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(700556) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 700631..701395 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 700631..701395 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 701402..702370 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 701402..702370 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 702394..703305 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 702394..703305 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 703183..703192 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 703205..703224 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 703208 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 703334..704512 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 703334..704512 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 704053..704059 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 704074..704093 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 704088 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 704513..705448 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 704513..705448 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 705320 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 705430 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(705471) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(705479..706708) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(705479..706708) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(706737..706756) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(706755) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(706772..706779) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(706819..707526) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(706819..707526) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(706848) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(707549..707568) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(707572) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(707618..709003) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(707618..709003) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(707640) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(709052..709071) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(709069) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(709086..709093) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 709171..709178 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 709186 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 709192..709210 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 709253..710710 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 709253..710710 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(710046..710065) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(710060) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(710078..710087) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 710724..711584 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 710724..711584 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 711568 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 711652..711659 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 711673..711692 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 711678 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 711719..713608 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 711719..713608 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 713592 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 713672..713691 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 713680 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 713731..714177 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 713731..714177 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(713733) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(713817..713820) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(713822) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(713838..713839) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 714164 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 714240..714247 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 714261..714280 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 714273 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 714302..714724 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 714302..714724 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 714560 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 714790..715980 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 714790..715980 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(716044) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 716271..716426 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 716271..716426 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(716546..718102) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(716546..718102) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(716570) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 717932..717938 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 717953..717964 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 717970 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(718152..718171) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(718156) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(718187..718191) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 718212..718215 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 718231..718250 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 718234 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 718275..719405 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 718275..719405 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 719388 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 719473..719919 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 719473..719919 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(719972..720991) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(719972..720991) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(719982) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(721012..721031) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(721016) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(721018..721472) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(721044..721051) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 721110..721117 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 721131..721150 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 721138..722235 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 721138 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(721473..722693) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(721473..722693) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(722730..722749) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(722737) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(722765..722772) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 722791..722798 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 722810..722985 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 722810 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 722813..722832 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 722942 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 723029..724492 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 723029..724492 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(723394..725064) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 724493..724986 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 724974..724979 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 724988..728253 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 724988 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 724995..725013 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(725065..725865) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(725065..725865) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(725878..726879) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(725878..726879) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(726465..726484) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(726477) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(726499..726506) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(726876..727877) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(726876..727877) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(727947..727966) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(727949..728896) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(727949..728896) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(727968) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(727968) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 728223..728228 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 728244..728262 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 728255..728880 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 728255 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 728876..728895 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 728882..729413 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 728882 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(728938..728957) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(728945) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(728971..728978) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(729005..729373) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(729005..729373) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(729374..729486) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(729475..729494) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(729486) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(729506..729513) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 729554..729560 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 729574..729592 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 729574 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 729617..729964 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 729617..729964 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(729618) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 729960 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 730005..730085 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 730086..730105 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 730087 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 730155..731417 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 730155..731417 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 731412 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 731470..731473 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 731488..731507 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 731496 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 731544..732980 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 731544..732980 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 732972 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 733071..733090 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 733082 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 733107..734735 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 733107..734735 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 734707..735387 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 734707..735387 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 735390..736349 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 735390..736349 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 736318 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 736441..736448 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 736461..736480 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 736472..736544 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 736472 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 736545..737846 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 736545..737846 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 737843..737849 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737863..737874 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737864 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 737902..738696 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 737902..738696 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 738672 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 738751..738754 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 738769..738788 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 738782 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 738815..739906 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 738815..739906 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(739897..740172) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(739897..740172) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 739907..740238 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(740186..740205) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(740200) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(740220..740227) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 740239..740904 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 740239..740904 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(740945..741082) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(740945..741082) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(740959) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(741083..741213) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(741199..741217) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 741209..741214 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(741213) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 741224..742288 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 741225 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 741230..741248 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(741233..741238) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(741239..741394) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(741239..741394) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(741395..741500) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(741501..741815) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(741501..741815) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(741816..741896) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(741897..742646) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(741897..742646) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(742675..742694) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(742688) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(742690..743826) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(742706..742714) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 742757..742758 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 742778..742797 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 742781 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 742818..744176 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 742818..744176 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(743812..743831) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(743826) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(743845..743854) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 744062 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 744172 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(744209..746158) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(744209..746158) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(744226) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 745268..745274 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 745290..745308 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 745294..746258 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 745294 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(746159..746233) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(746210..746229) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(746233) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(746235..746757) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(746245..746249) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 746259..746396 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 746259..746396 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 746374 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 746375..746394 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 746415..746807 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 746415..746807 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(746755..746773) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(746770) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(746789..746794) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 746876..746882 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 746897..746915 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 746897 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 746932..748347 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 746932..748347 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(746933) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(746959..747059) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(746999) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(748344..749420) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(748344..749420) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 748348..751714 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(749444..749644) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(749444..749644) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(749660..750814) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(749660..750814) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(750795..752336) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(750795..752336) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(752386..752397) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(752389) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(752411..752417) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 752446..752453 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 752468..752487 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 752475 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(752521) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 752529..753941 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 752529..753941 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(752547..752647) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(752587) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 754012..755697 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 754012..755697 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(754318..754333) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(754325) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(754346..754355) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 755670..755674 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 755690..755709 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 755693 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 755718..756434 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 755718..756434 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 756427 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 756509..756512 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 756528..756547 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 756537 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 756574..757239 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 756574..757239 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 757220 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(757276..761664) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(757276..761664) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(757295) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(761697..761716) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(761714) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(761731..761734) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 761841..761847 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 761861..761879 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 761864 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 761907..762425 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 761907..762425 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 762411 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(762455) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 762456..764106 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(762465..763655) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(762465..763655) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(763656..763747) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(763748..763963) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(763748..763963) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(763807) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(763995..764014) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(764009) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(764029..764030) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 764076..764083 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 764098..764117 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 764108 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 764166..764636 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 764166..764636 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 764654..764974 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 764654..764974 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 764998..765825 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 764998..765825 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 765804..765810 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765825..765836 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 765843..765999 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 765843 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(765875) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 765974 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(766024..767199) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(766024..767199) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(766029) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 766636..766642 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 766658..766676 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 766662..767315 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 766662 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(767224..767243) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(767239) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(767257..767264) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 767305..767310 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 767317 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 767325..767343 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 767367..768422 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 767367..768422 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 768436..768442 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 768457..768468 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 768461 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 768493..769287 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 768493..769287 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 769275 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(769326..770168) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(769326..770168) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(769328) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(770169..771290) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(770169..771290) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(771331..771350) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(771349) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(771366..771370) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 771378..771385 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 771399..771418 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 771409 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 771435..771620 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 771435..771620 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 771599 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 771663..771669 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 771675 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 771684..771695 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 771721..772512 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 771721..772512 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 772510 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(772550..773410) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(772550..773410) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(772564) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(773430..773449) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(773444) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(773465..773468) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(773509..774468) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(773509..774468) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(773532) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(774479..774498) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(774482) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(774514..774517) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 774529..774533 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 774547..774566 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 774556 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 774587..775450 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 774587..775450 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 775451..775563 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 775564..776964 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 775564..776964 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 776976 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 777270..777277 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 777293..777312 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 777299 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 777306..777589 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 777590..777856 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 777590..777856 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(777804..777823) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(777822) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(777838..777841) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 777857..778338 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 778309..778312 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 778329..778348 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 778340..778587 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 778340 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 778588..779565 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 778588..779565 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 779566..779658 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 779615 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 779699..779705 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 779717..779736 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 779726 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 779761..780213 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 779761..780213 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 780243..780932 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 780243..780932 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 780937 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 781109..781127 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 781116 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 781164..782165 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 781164..782165 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 782169..783197 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 782169..783197 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 783211..784407 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 783211..784407 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(783212) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 784428..785804 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 784428..785804 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 785798 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 785851..785858 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 785871..785890 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 785879 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 785920..787737 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 785920..787737 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 787738..787744 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 787756 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 787759..787770 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 787791..787970 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 787791..787970 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 787954 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(788006..788335) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(788006..788335) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(788020) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(788385..788843) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(788385..788843) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(788844..788936) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(788937..789494) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(788937..789494) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 789360..789365 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 789373 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 789380..789398 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 789384..789971 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(789526..790293) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(789526..790293) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(790305..791528) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(790305..791528) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(791534..791848) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(791534..791848) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(791896..791915) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(791909) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(791930..791933) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 792140..792159 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 792143 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 792184..793533 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 792184..793533 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 793562..793581 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 793564 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 793598..794362 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 793598..794362 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(793742..793756) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(793772..793778) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(793772) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 794377..795960 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 794377..795960 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 795940 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 795989..795996 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 796011..796030 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 796019 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 796066..797787 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 796066..797787 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 797781..799595 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 797781..799595 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 799570 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 799677..799684 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 799698..799717 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 799702 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 799750..800154 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 799750..800154 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 800172..801029 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 800172..801029 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 801016 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 801123..802067 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 801123..802067 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(801934) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(801982..802082) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(802022) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 802242..803690 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 802242..803690 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 803717..804658 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 803717..804658 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 804668..805849 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 804668..805849 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 805839 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 805909..805915 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 805930..805949 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 805948 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 805973..807175 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 805973..807175 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 807172..807834 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 807172..807834 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 807842 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 807978..808913 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 807978..808913 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 808926..810116 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 808926..810116 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 810130..811287 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 810130..811287 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 810241..810246 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 810261..810279 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 810262 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(811285..811359) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(811328) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(811360..811908) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(811360..811908) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(811909..811988) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(811977..811996) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(811988) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(812010..812015) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 812111..812114 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 812130..812149 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 812137 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 812181..812813 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 812181..812813 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 812792 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 812928..812933 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 812947..812966 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 812957 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 813002..814090 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 813002..814090 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(813492..813880) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(813880) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(813882..813901) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(813914..813922) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(814126..814743) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(814126..814743) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(814144) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(814709..815962) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(814709..815962) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(814770..814789) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(814782) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(814803..814810) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(815996..816015) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(816014) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(816030..816037) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 816041..816060 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 816046 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 816086..816622 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 816086..816622 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(816619..818175) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(816619..818175) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(818197..818215) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(818214) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(818231..818234) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(818286..818768) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(818286..818768) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(818302) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(818793..818812) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(818809) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(818827..818833) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 818854..818861 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818875..818894 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 818883 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 818940..821510 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 818940..821510 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 821481 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(821528..822505) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(821528..822505) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(821539) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 822520..822527 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(822532..822551) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 822542..822561 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 822544..822635 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 822544 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(822549) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(822566..822573) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 822636..823637 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 822636..823637 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 823634..824665 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 823634..824665 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 824646 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 824716..824718 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 824734..824753 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 824737 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 824780..825661 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 824780..825661 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 825672..825679 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 825695..825714 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 825704 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 825749..826333 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 825749..826333 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 826320 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(826372..826563) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(826372..826563) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(826390) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(826595) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(826598..826609) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(826624..826630) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(826630..826740) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(826630..826740) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(826769..826780) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(826771) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(826795..826801) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(826795..827706) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(826795..827706) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 827592..827595 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827612..827631 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 827622..827794 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 827622 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(827728..827746) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(827742) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(827760..827766) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 827795..828589 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 827795..828589 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 828591..828905 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 828591..828905 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(828813..829081) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 828895 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 828979..828984 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 829000..829019 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 829005 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 829048..830241 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 829048..830241 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 830242..830476 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(830274..830426) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(830274..830426) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(830291) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 830455..830462 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 830476..830495 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 830478..830550 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 830478 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(830485..830496) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(830495) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(830511..830517) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 830551..830820 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 830551..830820 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 830809 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 830898..830904 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 830919 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 830920..830938 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 830965..831483 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 830965..831483 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 831484..831551 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 831519..831528 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 831540..831555 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 831553 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 831568..831900 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 831568..831900 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 831887..832747 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 831887..832747 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 832745 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 832805..832811 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 832825..832836 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 832833..832897 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 832833 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(832855..832874) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(832864) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 832880..832886 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(832888..832889) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 832899..832979 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 832899 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 832901..832919 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 832980..833969 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 832980..833969 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(833129) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(833134..833138) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(833155..833159) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 833970..834040 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 834041..836626 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 834041..836626 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 836595 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(836619..837602) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(836619..837602) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(836653) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 837076..837085 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 837098..837117 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 837102 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(837603..837750) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 837707..837711 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 837727..837746 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 837734 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 837740..837817 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(837748..837767) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(837750) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(837782..837789) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 837818..838927 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 837818..838927 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 838764..838768 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 838784..838803 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 838796 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 838928..839240 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(838935..839159) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(838935..839159) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(839189..839200) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(839191) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(839214..839220) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 839241..839993 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 839241..839993 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 840010..840016 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 840031..840042 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 840032 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(840039..840053) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(840060) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(840062..840066) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 840062..840316 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 840062..840316 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 840314 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(840339) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 840405..840749 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 840405..840749 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 840412..840420 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 840431..840449 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 840433 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 840732 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 840788..840795 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 840809..840828 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 840818..840892 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 840818 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 840893..841423 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 840893..841423 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 841414 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 841511..843253 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 841511..843253 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 843240 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(843330..844391) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(843330..844391) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(843341) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(844392..844482) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(844480..844499) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(844489) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(844514..844521) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(844611..845900) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(844611..845900) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(844614) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(845928..845947) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(845947) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(845949..846660) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(845959..845964) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 845993..846000 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846014..846033 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 846014 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 846053..846526 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 846053..846526 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 846563..846570 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846585..846604 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 846591 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 846649..847086 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 846649..847086 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 847068 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(847121..847474) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(847121..847474) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 847134 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(847144) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 847470..847474 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 847482..847496 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(847486..847505) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 847486..847577 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 847486 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(847496) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 847554..847557 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 847572..847591 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 847579..847681 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 847579 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 847682..848566 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 847682..848566 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 848549..848556 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 848570..848589 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 848585..848857 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 848585 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(848618) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 848858..850412 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 848858..850412 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 850580..853507 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 850580..853507 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 853508..853593 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 853569..853576 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 853590..853609 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 853595 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 853619..853734 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 853619..853734 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 853744..853818 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 853744..853818 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 853824..853915 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 853824..853915 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 853911 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 853950..854021 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 853950..854021 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 854031..854106 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 854031..854106 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 854116..854192 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 854116..854192 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 854204..854280 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 854204..854280 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 854293..854368 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 854293..854368 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 854374..854446 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 854374..854446 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 854469..854553 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 854469..854553 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 854559..854632 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 854559..854632 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 854657..854732 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 854657..854732 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 854742..854813 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 854742..854813 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 854863..854937 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 854863..854937 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 854943..855013 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 854943..855013 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 855021..855109 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 855021..855109 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 855110..855186 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 855143 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 855188..855356 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 855313..855320 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 855319 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 855334..855353 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 855358 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 855375..855456 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 855375..855456 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(855392..855409) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(855395) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(855430..855435) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(855465) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(855535..856311) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(855535..856311) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(855549) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(856338..856353) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(856360) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(856366..856375) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 856395..856401 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 856416..856427 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 856419 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 856453..856656 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 856453..856656 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 856639 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(856715) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(856741..857013) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(856741..857013) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(856972..856990) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(856979) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 856994..857001 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(857007..857012) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 857014..857033 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 857022 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 857055..857747 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 857055..857747 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 857776..857780 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(857779..857798) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(857791) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 857794..857813 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(857813..857820) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 857817..857924 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 857817..857924 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 857824 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 857955 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 858057..859829 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 858057..859829 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 859805 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 859850..860775 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(859867..861222) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(859867..861222) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(861250..861269) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(861267) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(861283..861292) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 861340..861346 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 861361..861380 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 861389 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 861473..861670 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 861473..861670 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(861697..863148) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(861697..863148) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(861707) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 863125..863131 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 863146..863165 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 863149 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(863166..863185) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 863171..863500 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(863185) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(863199..863206) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(863244..863262) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(863269) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 863457 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 863556..864323 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 863556..864323 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 864341..865339 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 864341..865339 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 865336..866166 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 865336..866166 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 866189..867319 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 866189..867319 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 867346..867365 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 867352 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 867423..867959 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 867423..867959 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 867960..868030 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 868000..868007 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868021..868040 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868032 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 868071..868340 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 868071..868340 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 868143..868147 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868170..868186 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868186 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 868327 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(868358..868831) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(868358..868831) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(868394) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(868833..869033) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(868833..869033) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(869062..869081) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(869076) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(869094..869101) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 869157..869162 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 869176..869195 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 869176 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 869227..869300 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 869227..869300 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 869301..869483 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(869391..870014) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(869391..870014) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(869406) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 869440 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 869485..870096 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(870038..870057) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(870059) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(870071..870078) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 870097..871257 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 870097..871257 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 871266 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 871283..871295 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 871288 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 871324..872259 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 871324..872259 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(871342) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 872243..872246 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 872261 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 872262..872281 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 872297..872779 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 872297..872779 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 872762 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 872829..873545 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 872829..873545 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 872849..872856 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 872871..872890 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 872872 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 873536..874249 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 873536..874249 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 874261..874968 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 874261..874968 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 874852 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 874896 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 874962 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(874995..875170) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(875038) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(875162..875181) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(875170) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(875196..875203) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 875235..875240 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875256..875274 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 875256 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 875318..877213 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 875318..877213 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 875760..875860 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 875820 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 875886 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 877206 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 877270..877275 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877291..877309 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 877294..877392 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 877294 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 877393..878571 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 877393..878571 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 877591..877594 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877609..877628 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877613 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(877854) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 878550 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 878658..878665 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 878680..878699 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 878680 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 878731..879195 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 878731..879195 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 879020..879026 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 879041..879059 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 879054 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 879204..879210 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 879224..879235 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 879230 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 879231..879896 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 879231..879896 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 879937..881535 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 879937..881535 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 881558..882088 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 881558..882088 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 882101..882475 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 882101..882475 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 882464 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 882475..882630 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 882475..882630 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 882565..882571 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 882586..882605 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 882596 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 882635..883396 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 882635..883396 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(882948..882966) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(882962) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(882982..882987) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 883399..883764 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 883399..883764 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 883766..884464 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 883766..884464 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 884481..885398 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 884481..885398 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 885391..886332 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 885391..886332 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 886314 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(886424..886627) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(886424..886627) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(886438) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(886628..886755) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 886715..886726 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 886732 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(886744..886763) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(886755) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(886757..887895) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(886777..886782) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 886922..886929 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 886944..886962 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 886951 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 886952..887062 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 887063..887893 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 887063..887893 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 887852 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(887896..888975) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(887896..888975) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(888985..889004) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(889006) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(889020..889024) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 889082..889089 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 889103..889122 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 889109 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 889148..890539 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 889148..890539 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(890175..890578) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 890518 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(890579..891034) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(890579..891034) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(891049..891067) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891077) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(891082..891088) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 891126..891132 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 891146..891157 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 891150 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 891184..891753 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 891184..891753 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 891380..891386 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 891397 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 891400..891411 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 891728 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 891796..891805 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 891819..891838 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 891829 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 891874..892842 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 891874..892842 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 892718 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(892774..893427) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(892774..893427) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(892791) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(893458..893469) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(893460) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(893484..893490) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 893499..893507 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 893510..897163 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 893510..897163 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 893518..893536 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 893533 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 897160..897756 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 897160..897756 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 897735 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(897786..898694) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(897786..898694) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 898750..898758 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(898751..898762) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(898757) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(898759..899245) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 898769 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 898772..898791 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(898776..898782) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 898805..899200 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 898805..899200 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(899231..899250) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(899245) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 899285..899291 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 899300 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 899305..899316 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(899315..899329) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(899329) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(899337..899341) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 899337..899759 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 899337..899759 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(899663..899763) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(899703) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 899737 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(899769) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 899809..899816 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 899830..899849 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 899838 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 899886..900548 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 899886..900548 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 900564..902105 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 900564..902105 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 902088 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 902189..902380 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 902189..902380 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 902411..902418 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 902433..902452 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 902444..902525 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 902444 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 902526..903878 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 902526..903878 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 903906..904484 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 903906..904484 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 904479..904486 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 904501..904520 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 904512 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 904527 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 904572..904662 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 904663..905487 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 904663..905487 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 905506..906996 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 905506..906996 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 906307..906313 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 906328..906347 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 906338 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 906997..907085 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 907042 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 907048..907148 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 907108 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 907137..908804 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 907137..908804 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 908566..908571 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 908586..908604 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 908595 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 908649..908655 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 908670 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 908671..908689 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 908772 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 908817..908890 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 908872..908879 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 908892 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 908893..908912 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 908936..910681 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 908936..910681 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 910670 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 910715..910784 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 910786..910805 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 910786 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 910830..911969 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 910830..911969 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 911966..912610 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 911966..912610 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 912607..913131 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 912607..913131 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 913096 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(913146..913388) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(913146..913388) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(913167) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(913424..913435) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(913435) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(913449..913456) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 913523..913529 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 913543..913554 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 913553 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 913589..913912 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 913589..913912 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 913913..915779 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(913954..915420) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(913954..915420) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(913966) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(914053) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(915460..915478) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(915472) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(915492..915499) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(915573..916013) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(915573..916013) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(915603) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 916001..916007 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 916021..916032 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 916023..916133 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 916023 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(916035..916054) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916051) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(916066..916072) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 916092 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(916120..917778) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(916120..917778) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(916125) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(917669..917687) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(917689) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(917701..917707) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 917750..917755 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 917771..917789 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 917784 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 917809..919215 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 917809..919215 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 919195 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(919245..920630) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(919245..920630) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(919271) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(920657) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(920659..922190) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(920667..920678) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 920786..920793 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 920806..920825 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 920812..921099 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 920812 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 921062..921065 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 921080..921099 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 921101 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 921160..922164 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 921160..922164 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 922026 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 922156 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(922190) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(922197..922212) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 922202 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(922224..922233) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(922235..923110) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(922235..923110) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 923163..923164 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(923176..923195) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 923181..923200 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(923182) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 923191 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(923210..923215) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 923219..924319 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 923219..924319 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 924330..924336 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 924351..924369 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 924356 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 924393..925262 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 924393..925262 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 925270 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 925347..925350 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 925362 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 925365..925384 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 925410..925429 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 925415..925511 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 925415 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 925512..926909 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 925512..926909 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 926889 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 926970..926974 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926990..927009 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926997 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 927027..928382 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 927027..928382 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 928363 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(928417..929826) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(928417..929826) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 929875..929878 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 929893..929912 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 929895 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(929897..929916) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(929909) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(929932..929936) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 929936..930364 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 929936..930364 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 930343 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(930395..930685) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(930395..930685) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(930419) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(930673..931749) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(930673..931749) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(931739..932230) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(931739..932230) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(932231..932333) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(932322..932341) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(932333) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(932355..932358) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 932371..932377 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 932388 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 932392..932410 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(932421) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 932427..933422 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 932427..933422 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 933401 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 933484..933487 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 933502..933521 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 933507 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 933557..934156 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 933557..934156 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 934171 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 934216..936170 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(934225..935559) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(934225..935559) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(934244) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(935620..936051) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(935620..936051) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(936063..936082) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(936073) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(936097..936103) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(936099..936199) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 936134..936141 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(936139) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 936155..936174 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 936172 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 936208..937389 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 936208..937389 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 937374 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 937419..937557 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 937553..937572 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 937559..937715 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 937559 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 937716..939101 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 937716..939101 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 938991 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 939077 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(939115..939471) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(939115..939471) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(939468..939863) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(939468..939863) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(939850..940581) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(939850..940581) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(940606..940625) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(940627) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 940674..940682 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 940691 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 940696..940711 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 940705..940778 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 940765..940766 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 940780 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 940782..940801 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 940815..940922 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 940815..940922 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 940923..940976 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 940947 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 941027..941046 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 941033 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 941071..942186 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 941071..942186 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 942166 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 942223..942242 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 942223 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 942256..942999 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 942256..942999 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 942971 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(943023..943871) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(943023..943871) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(943047) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 943867..943872 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(943872..943971) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 943888..943906 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 943890 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 943895..944090 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(943960..943979) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(943974) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(943994..943997) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 944089..944108 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 944092..944155 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 944092 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 944156..945004 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 944156..945004 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 944995 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(945047..946408) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(945047..946408) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(945071) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(946409..946479) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(946452..946471) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(946479) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(946535..947035) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(946535..947035) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(946567) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(947057..947075) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(947077) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(947090..947096) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 947114..947121 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 947129..947198 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 947130 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 947136..947155 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 947199..947360 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 947199..947360 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 947290 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 947361..947479 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 947480..949237 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 947480..949237 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 949234..951255 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 949234..951255 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 951243 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(951304..951924) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(951304..951924) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(951319) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 951909..952009 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(951938..951957) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(951953) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(951963..952088) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(951963..952088) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 951969 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(951972..951975) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(952102..952121) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(952111) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(952135..952144) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 952167 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(952193..952396) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(952193..952396) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(952198) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(952397..952507) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 952437..952537 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 952497 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(952513) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(952517..952528) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(952543..952549) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(952605..952823) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(952605..952823) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(952639) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(952864..952883) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(952881) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(952897..952904) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(952973..954334) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(952973..954334) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(952991) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(953035) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(954324..955415) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(954324..955415) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(954739..954753) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(954751) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(954767..954775) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(955416..955521) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(955505..955523) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(955525) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(955539..955544) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 955587..955594 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 955609..955628 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 955620 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 955682..956815 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 955682..956815 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 956816..956907 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 956908..957261 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 956908..957261 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 957249 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(957305..958378) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(957305..958378) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(957412) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(958400..958419) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(958412) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(958433..958440) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 958515..958522 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 958535 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 958537..958556 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 958546..958699 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 958656 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 958701..958784 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 958741 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 958797..958802 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 958818..958836 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 958827 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 958864..959730 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 958864..959730 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 959712 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 959775..959778 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 959793..959812 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 959801 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 959842..961347 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 959842..961347 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 961317 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(961365..962582) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(961365..962582) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(961371) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(962589..963086) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(962589..963086) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(963150..963488) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(963150..963488) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(963500..963519) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(963524) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(963533..963540) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 963560..963567 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 963582..963601 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 963592 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 963653..964420 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 963653..964420 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 964421 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(964441..964626) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(964441..964626) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(964662..964680) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(964673) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(964691..964699) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 964700..964703 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 964718..964737 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 964728 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 964753..965649 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 964753..965649 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 965642..966901 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 965642..966901 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 966885 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 966949..966956 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 966968..966987 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 966973 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 967008..968234 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 967008..968234 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(967709) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 968239..971130 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 968239..971130 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 969520..969525 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 969541..969559 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 969547 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 971138..971143 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 971158..971177 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 971173 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 971204..972148 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 971204..972148 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 972126 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 972207..972212 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 972228..972246 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 972231 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 972273..972485 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 972273..972485 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 972478 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(972516) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(972526..973404) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(972526..973404) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(972714) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(973442..973461) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(973466) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(973475..973482) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 973502..973511 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 973523 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 973524..973543 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(973560..973574) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(973561) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 973564..973650 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 973564..973650 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(973583..973587) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 973651..973902 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 973775..973861 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 973775..973861 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 973859 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(973871..974133) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 973904..974387 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(973914) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(974126..974145) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974133) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(974135..974203) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(974159..974164) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(974204..974722) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(974204..974722) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 974509..974517 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 974529..974547 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974542 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(974753..974772) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974771) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974788..974794) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 974871..974874 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 974889..974908 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974894 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 974930..975271 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 974930..975271 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(975125..975267) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(975168) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(975268..975879) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(975268..975879) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 975272..976037 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(975344) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 975875..975879 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 975887..975900 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 975899 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(975904..975923) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(975927) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(975938..975941) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 975994 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(976057..976413) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(976057..976413) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(976061) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 976490..976495 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(976496..976515) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(976510) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 976511..976529 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 976511 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(976512..976775) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 976543..976734 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 976543..976734 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 976735..978170 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(976808..977326) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(976808..977326) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(976820) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(977327..977414) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(977406..977425) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977414) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(977439..977446) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(977451..978530) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(977451..978530) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(978569..978588) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(978580) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(978582..978663) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(978677..979114) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(978677..979114) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(978708) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(979147..979166) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(979161) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 979164 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(979180..979187) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(979186..979482) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(979229) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(979480..979491) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(979486) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(979506..979512) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 979542..979549 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 979563..979582 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 979572 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 979602..980345 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 979602..980345 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 980338..981564 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 980338..981564 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(980897..980915) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(980912) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(980931..980936) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 981584..982294 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 981584..982294 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 982258 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(982312..983502) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(982312..983502) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(982322) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(982387) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(983526..983545) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(983547) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(983559..983564) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(983575..984966) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(983575..984966) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(984977..984996) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(984982) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(985009..985018) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(985032..985346) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(985032..985346) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(985391..985891) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(985391..985891) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(985418) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(985904..985923) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 985906..985910 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(985925) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 985926..985945 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 985927 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(985940..985941) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 985958..985964 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 985979..985990 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 985984 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 986013..988157 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 986013..988157 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(986057..986068) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(986060) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(986082..986088) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 988194..988200 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 988214..988233 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 988224 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 988279..989340 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 988279..989340 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 989412..990344 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 989412..990344 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 990359..991771 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 990359..991771 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 990362 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 991748 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 991832..991839 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 991853..991872 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 991858 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 991917..992492 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 991917..992492 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 992236..992239 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 992254 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 992256..992275 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 992493..992562 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 992563..994890 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 992563..994890 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 994872 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(994932..995909) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(994932..995909) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(994945) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(995923..995942) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995941) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(995956..995962) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 995968..995976 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 995987..996005 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 995994 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 996036..996812 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 996036..996812 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(996528..997149) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 996813..997184 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(997127..997146) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(997148) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(997160..997169) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 997162..997169 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 997184..997203 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 997186 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 997225..998265 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 997225..998265 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 998278..998685 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 998278..998685 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 998656 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(998722..1000011) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(998722..1000011) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(998752) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(1000012..1000112) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1000111..1000130) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1000112) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1000114..1000250) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1000145..1000151) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1000282..1000422) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(1000282..1000422) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(1000295) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1000441..1000460) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1000460) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1000473..1000480) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1000504..1000510 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1000524..1000543 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1000527 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 1000574..1001308 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 1000574..1001308 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 1001321..1002316 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 1001321..1002316 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 1002381..1003025 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 1002381..1003025 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 1003013 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1003053..1003056 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1003071..1003090 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1003078 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 1003142..1004683 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 1003142..1004683 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 1004663 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1004722..1005117) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(1004722..1005117) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(1004739) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1005137..1005148) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005141) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005163..1005169) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1005202..1005205 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1005213 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1005220..1005239 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1005266..1006546 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 1005266..1006546 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(1005693..1005712) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005707) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005728..1005733) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1006533 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(1006583) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1006585..1007730) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(1006585..1007730) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(1007731..1007797) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1007786..1007805) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1007803) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1007821..1007825) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1008110..1008117 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1008132..1008151 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1008134 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 1008165..1008614 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 1008165..1008614 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 1008630..1008637 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1008652..1008671 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1008659 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1008686..1009678 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 1008686..1009678 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 1009679 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 1009724..1009834 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1009812..1009819 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1009835..1009854 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1009836 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1009895..1010866 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 1009895..1010866 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 1010845 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1010898..1011479) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(1010898..1011479) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(1010921) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1011503..1011522) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1011515) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1011538..1011541) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1011550..1012644) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(1011550..1012644) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(1012641..1014080) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(1012641..1014080) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(1014087..1014647) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(1014087..1014647) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(1014097..1014116) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1014111) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1014672..1014691) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1014686) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1014706..1014713) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1014782..1016080) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(1014782..1016080) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(1014793) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1016134..1016152) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1016137) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1016166..1016172) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1016219..1017748) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(1016219..1017748) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(1017775..1017793) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1017785) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1017804..1017809 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1017808..1017813) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1017821 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1017825..1017843 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1017860..1018717 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 1017860..1018717 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 1018699 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1018745..1018978) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(1018745..1018978) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(1018778) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1018995..1019014) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1018998..1018999 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1018998 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1019002..1019017 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1019017) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1019019..1019874) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1019029..1019036) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1019201..1019208 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1019220..1019239 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1019226 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 1019271..1019849 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 1019271..1019849 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 1019850..1019995 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1019896..1020795) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(1019896..1020795) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(1019919) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1019982..1019985 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1019997 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1020003..1020007 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1020041 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1020086..1020952 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1020822..1020840) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1020839) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1020855..1020861) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1020929..1020936 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1020951..1020970 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1020954 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1021012..1021281 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 1021012..1021281 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 1021273 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1021321) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1021324..1022793) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(1021324..1022793) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(1022790..1022990) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(1022790..1022990) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(1022991..1023109) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1023092..1023111) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1023109) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1023124..1023131) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1023197) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1023198..1023560) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(1023198..1023560) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 1023398..1023403 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1023419..1023437 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1023420 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1023429..1023668 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1023590..1023609) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1023608) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1023624..1023631) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1023650..1023657 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1023670 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1023671..1023690 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1023712..1024335 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 1023712..1024335 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 1024337..1024843 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 1024337..1024843 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 1024836 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1024894..1024901 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1024915..1024934 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1024924..1025023 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1024924 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 1025024..1026523 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 1025024..1026523 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 1026531..1026538 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1026550 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1026552..1026571 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1026600..1027127 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 1026600..1027127 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 1027089 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(1027141..>1027161) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" SCAR join(1027161,1027177) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" N_region 1027162..1027176 /note="inserted sequence possibly derived from two restrictions with NotI and SacI" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" S_feature <1027177..1027463 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(<1027177..1027298) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1027183) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1027299..1028453) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(1027299..1028453) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(1028454..1028525) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1028508..1028527) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1028524) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1028541..1028546) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1028560..1029765) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(1028560..1029765) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 1029786..1029805 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1029791 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1029879..1031606 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 1029879..1031606 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 1031192..1031199 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1031214..1031233 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1031221 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1031636..1031962) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(1031636..1031962) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(1032080..1032517) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(1032080..1032517) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(1032089) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1032548..1032567) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1032568) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1032580..1032589) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1032637..1032644 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1032658..1032677 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1032670 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 1032701..1036201 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 1032701..1036201 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 1036188..1039886 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 1036188..1039886 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 1039887..1039957 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1039958..1041133 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 1039958..1041133 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 1041130..1044522 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 1041130..1044522 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 1043777..1043783 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1043798..1043809 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1043805 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1043874..1044847) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1044536..1044838 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 1044536..1044838 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 1044818 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(1044892) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" SCAR 1044896..1044897 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27_007" downshifts 1044916 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1044955..1045542) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(1044955..1045542) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(1045557..1045576) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1045576) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1045592..1045594) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1045597..1045603 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1045615 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1045618..1045636 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1045621..1045687 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1045688..1047532 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 1045688..1047532 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 1047533..1047600 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1047557 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1047662..1048141) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(1047662..1048141) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(1048161) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1048165..1048183) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1048194..1048202) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1048333..1048337 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1048350 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1048352..1048371 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1048373..1049197 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 1048373..1049197 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 1048585..1048591 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1048606..1048624 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1048613 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1049207..1050657 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1049227..1050594) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(1049227..1050594) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 1050626..1050633 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1050647..1050666 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1050659 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 1050718..1051581 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 1050718..1051581 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 1051599..1052612 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 1051599..1052612 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 1052595 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 1052664..1052671 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1052686..1052705 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1052705..1052820 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1052705 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 1052821..1053849 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 1052821..1053849 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 1053871 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1053900..1054409) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(1053900..1054409) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(1053919) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1054422..1054440) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1054438) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1054452..1054460) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1054459..1055121) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(1054459..1055121) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 1055140..1055146 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1055160..1055179 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1055169 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 1055188..1056642 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 1055188..1056642 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(1056497..1056649) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1056532) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1056650..1057288) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(1056650..1057288) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(1057289..1057423) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1057337..1057342 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1057358..1057376 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1057359 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 1057369..1057493 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1057409..1057428) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1057423) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1057443..1057450) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1057494..1058300 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 1057494..1058300 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1058293 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1058328..1058927) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1058328..1058927) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1058347) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1058924..1060093) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1058924..1060093) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1060094..1060205) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1060206..1060916) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1060206..1060916) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1060960..1060979) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1060982) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1060992..1061001) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1061031..1061040 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1061054..1061073 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1061065 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1061101..1061787 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1061101..1061787 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1061784..1062542 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1061784..1062542 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1062539 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1062587..1063216) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1062587..1063216) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1063250..1063268) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1063267) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1063283..1063288) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1063312..1064427) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1063312..1064427) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1063341) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1064436..1065704) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1064436..1065704) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1065730..1065741) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1065739) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1065755..1065761) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1065816..1066664) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1065816..1066664) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1065827) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1066669..1067118) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1066669..1067118) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1067139..1067158) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1067153) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1067174..1067175) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1067208..1069046) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1067208..1069046) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1067235) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1069128) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1069136..1069253) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1069136..1069253) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1069305..1069324) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1069319) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1069339..1069346) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1069360..1069851) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1069360..1069851) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1069869..1069872 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1069875..1069894) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1069887..1069906 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1069888 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1069893) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1069909..1069916) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1069950..1070846 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1069950..1070846 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1070833 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1070909) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 1070921..1070922 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_016" S_feature <1070922..1070975 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" promotor_-10 complement(<1070922..1070936) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1070940) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1070954..1070959 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1070974..1070992 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1070977 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1071014..1071856 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1071014..1071856 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1071509..1071517 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1071528..1071546 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1071528 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1071857..1071970 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1071971..1072330 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1071971..1072330 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1072319 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1072361..1072558) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1072361..1072558) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1072374) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1072559..1072755) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1072755) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1072757..1072768) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1072783..1072789) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1072815..1073627) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1072815..1073627) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1073665..1073684) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1073685..1073692 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1073685) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1073698..1073705) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1073704..1073723 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1073706 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1073748..1074515 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1073748..1074515 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1074524..1074530 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1074544 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1074545..1074564 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1074579..1074887 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1074579..1074887 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1074872 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1074917..1075182 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1075183..1076613 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1075183..1076613 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1076658..1077152 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1076658..1077152 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1077116 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1077290..1077297 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1077296 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1077311..1077330 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1077359..1078396 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1077359..1078396 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1078416..1079636 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1078416..1079636 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1079651..1080427 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1079651..1080427 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1080424..1081581 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1080424..1081581 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1081652..1082707 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1081652..1082707 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1082262,1082263) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1082541..1082560) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1082551) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1082700..1085792 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1082700..1085792 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1085780..1086739 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1085780..1086739 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1086702 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1086742..1087016) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1086767..1086773 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1086775) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1086788..1086799 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1086809 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1086825..1087004 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1086825..1087004 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1087014 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1087050..1087235) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1087050..1087235) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1087061) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1087264..1087283) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1087281) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1087294..1087301) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1087336..1087342 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1087354..1087373 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1087359 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1087416..1087425 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1087425 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1087438..1087457 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1087484..1088218 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1087484..1088218 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1087977..1088579) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1088199..1088204 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1088217 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1088217 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1088220..1088238 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1088300..1088857 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1088300..1088857 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1088559..1088578) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1088579) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1088593..1088597) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1088864..1088871 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1088886..1088905 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1088898 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1088948..1089901 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1088948..1089901 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1089565..1089569 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1089585..1089604 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1089598 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1089916..1090107 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1089916..1090107 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1090086 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1090131..1090471 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1090137..1090376) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1090137..1090376) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1090153) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1090389..1090408) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1090410) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1090422..1090431) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1090437..1090444 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1090459..1090478 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1090473 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1090541..1091479 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1090541..1091479 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1090618..1090627 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1090636 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1090639..1090654 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1091502..1092743 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1091502..1092743 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1091716..1091734) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1091724) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1091750..1091755) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1092594 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1092727 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1092768..1092777 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1092790..1092809 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1092792 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1092804..1092812 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1092819..1093604 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1092819..1093604 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1092824..1092842 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1092836 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1093605..1093689 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1093621..1093639) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1093638) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1093654..1093659) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1093657..1093664 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1093679..1093698 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1093691..1093795 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1093691 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1093796..1094782 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1093796..1094782 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1094779..1095768 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1094779..1095768 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1095774..1095780 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1095779..1095855 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1095779 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1095856..1096347 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1095856..1096347 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1096320..1097486 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1096320..1097486 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1097477 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1097562..1098512 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1097562..1098512 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1098529..1099440 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1098529..1099440 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1099454 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1099499..1099606 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1099579..1099584 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1099600..1099618 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1099608 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1099645..1100397 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1099645..1100397 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1100377 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1100432..1101424) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1100432..1101424) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1100453) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1101483..1101697) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1101483..1101697) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1101531) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1101716..1101735) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1101729) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1101984..1101991 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1102005..1102167 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1102006..1102025 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1102006 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1102168..1103805 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1102168..1103805 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1103699 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1103806..1103912 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1103913..1104848 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1103913..1104848 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1103956..1103975) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1103973) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1103991..1103997) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1104852..1105769 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1104852..1105769 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1105774..1106850 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1105774..1106850 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1106852..1107769 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1106852..1107769 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1107739 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1107819..1107822 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1107835 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1107837..1107856 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1107876..1109093 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1107876..1109093 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1109146..1109155 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1109168..1109183 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1109177..1109256 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1109177 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1109257..1109835 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1109257..1109835 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1109836..1109950 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1109887..1109906) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1109891) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1109920..1109927) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1109953..1109966 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1109953 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1110016..1110411 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1110016..1110411 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1110247..1110347) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1110287) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1110409 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1110454..1111243 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1110454..1111110) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1110454..1111110) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1111140..1111158) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1111155) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1111173..1111178) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1111216..1111223 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1111237..1111256 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1111245..1111386 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1111245 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1111280..1111420 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1111280..1111420 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1111387..1112043 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1111387..1112043 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1112033 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1112038..1112160) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1112038..1112160) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1112078..1112167 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1112146..1112154 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1112165..1112183 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1112169..1112233 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1112169 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1112234..1113355 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1112234..1113355 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1113009..1113015 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1113027 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1113030..1113048 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1113241..1113249 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1113261..1113279 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1113268 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1113349..1113355 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1113370..1113381 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1113379 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1113402..1115414 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1113402..1115414 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1113477..1113484 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1113499..1113518 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1113511 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1115361 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1115415..1115716 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1115452..1115619) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1115452..1115619) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1115465) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1115639..1115657) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1115655) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1115673..1115678) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1115709..1115716 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1115718..1115843 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1115718 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1115724..1115862 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1115724..1115862 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1115731..1115750 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1115800 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1115933..1116832) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1115933..1116832) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1115964) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1116168..1116173 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1116180 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1116189..1116207 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1116196..1118097 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1116829..1117227) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1116829..1117227) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1117228..1117407) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1117399..1117418) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1117407) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1117430..1117437) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1117482..1118027) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1117482..1118027) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1117506) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1118028..1118230) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1118231..1118803) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1118231..1118803) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1118376..1118394) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1118385) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1118407..1118414) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1118832..1118851) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1118849) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1118865..1118868 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1118866..1118873) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1118881 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1118884..1118903 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1118928..1119296 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1118928..1119296 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1119325..1119960 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1119325..1119960 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1119979..1120779 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1119979..1120779 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1120842..1121693 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1120842..1121693 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1121652 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1121706..1122440) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1121706..1122440) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1121728) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1122562..1122566 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1122583..1122602 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1122597 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1122598..1122674 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1122675..1124519 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1122675..1124519 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1123002..1123021) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1123026) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1124521..1124528 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1124542..1124561 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1124548 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1124581..1124689 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1124581..1124689 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1124684 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1124768..1125478 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1124768..1125478 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1125453..1126070 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1125453..1126070 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1126054..1127163 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1126054..1127163 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1127163..1127363 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1127163..1127363 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1127360..1128130 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1127360..1128130 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1128127..1129137 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1128127..1129137 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1129156..1129971 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1129156..1129971 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1129945 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1130018..1130024 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1130037..1130056 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1130047 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1130107..1130883 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1130107..1130883 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1130872 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" SCAR 1130887..1130888 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_009" S_feature <1130888..1131948 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1130892..1133171) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1130892..1133171) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1130910) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1133046..1133220) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1133099..1133107 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1133118..1133136 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1133122..1133257 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1133122 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1133208..1133227) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1133219) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1133235..1133241 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1133243..1133247) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1133256..1133274 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1133259 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1133288..1133542 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1133288..1133542 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1133518 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1133608) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1133615..1134037) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1133615..1134037) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1134041..1134556) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1134041..1134556) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1134593..1135315) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1134593..1135315) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1135354..1135373) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1135375) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1135424..1135431 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1135446..1135465 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1135450 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1135483..1135603 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1135483..1135603 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1135608 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1135671..1136792 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1135671..1136792 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1136785..1137957 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1136785..1137957 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1137940 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1137974..1137992 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1137984 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1137985..1139514 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1137990..1138535) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1137990..1138535) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1138011) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1138605..1139795) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1138605..1139795) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1139821..1139840) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1139825) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1139855..1139862) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1139889..1139896 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1139900 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1139910..1139929 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1139968..1140040 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1139968..1140040 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1139982..1139999) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1139996) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1140020..1140026) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1140030 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1140055..1140790) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1140075..1141723 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1140084) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1140792..1140880) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1140835) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1140881..1142110) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1140881..1142110) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1141003) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1141680 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1142111..1142196) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1142151..1142158 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1142173..1142192 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1142182..1142201) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1142186 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1142200) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1142214..1142220) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1142236..1142556 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1142236..1142556 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1142566 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1142611..1142708 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1142709..1142840 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1142709..1142840 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1142856..1143029 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1142856..1143029 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1143066..1143527 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1143066..1143527 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1143498..1143505 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1143520..1143539 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1143528..1143768 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1143528 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1143741..1143748 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1143762..1143780 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1143770 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1143793..1144296 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1143793..1144296 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1144308..1144592 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1144308..1144592 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1144562 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1144594) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1144605..1144608) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1144753..1145280 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1144753..1145280 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1145427..1145432 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1145445..1145464 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1145448 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1145454..1145771 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1145454..1145771 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1145772..1146007 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1146008..1146763 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1146008..1146763 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1146764..1146851 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1146808 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1146851..1146911) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1146882) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1146912..1147259) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1146912..1147259) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1147291..1147309) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1147304) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1147306..1147762) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1147320..1147328) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1147722..1147740 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1147734 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1147740..1147759) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1147762) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1147773..1147780) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1147810..1149756 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1147810..1149756 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1149732 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1149786..1149787 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1149787..1149885 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1149860..1149866 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1149881..1149900 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1149887..1149955 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1149887 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1149956..1150438 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1149956..1150438 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1150418 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1150484..1150990) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1150484..1150990) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1150508) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1151015..1151034) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1151021) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1151023..1151208) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1151209..1151604) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1151209..1151604) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1151627..1151645) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1151640) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1151642..1152342) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1151660..1151665) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1151748..1151755 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1151769..1151788 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1151780 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1151833..1152312 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1151833..1152312 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1152311 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1152352..1152546) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1152352..1152546) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1152387) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1152560..1152575) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1152576) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1152587..1152596) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1152712..1153041) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1152712..1153041) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1153078..1153097) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1153091) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1153093..1153660) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1153112..1153117) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1153145..1153149 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1153165..1153184 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1153169..1153670 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1153169 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1153661..1154650) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1153661..1154650) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1154651..1154670) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1154654) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1154684..1154689) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1154773..1155021) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1154773..1155021) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1154783) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1155017..1155021 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1155030..1155044 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1155039 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1155046..1155065) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155055) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1155079..1155088) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1155136..1155143 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1155150..1155169) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1155157..1155176 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155159) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1155170 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1155171..1155274 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1155183..1155190) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1155275..1156678 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1155275..1156678 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1156667 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1156718..1157191) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1156718..1157191) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1156722) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1157213..1157231) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1157231) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1157246..1157251) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1157316..1157483) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1157316..1157483) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1157319) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1157495..1157513) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1157504) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1157526..1157533) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1157610..1158509 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1157610..1158509 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1158518..1158916) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1158518..1158916) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1158548) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1158945..1158964) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1158964) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1158979..1158986) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1159017..1159592) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1159017..1159592) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1159032) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1159611..1159629) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1159626) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1159643..1159649) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1159667..1159673 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1159688..1159706 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1159689 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1159738..1162695 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1159738..1162695 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1162688..1163248 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1162688..1163248 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1163241 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1163286..1163404 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1163382..1163385 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1163401..1163420 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1163406 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1163445..1164086 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1163445..1164086 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1163454) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1164059 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1164165..1164791 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1164165..1164791 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1164793 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1164796) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1164822..1165100) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1164822..1165100) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1164840) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1165129..1165140) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1165142..1165148) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1165148) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1165150..1165566) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1165318 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1165319..1165338 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1165336..1165490 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1165491..1166681 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1165491..1166681 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1165564..1165583) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1165566) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1165597..1165606) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1166704..1167882 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1166704..1167882 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1167923..1168111) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1167923..1168111) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1167939) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1168137..1168156) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1168140) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1168170..1168176) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1168198..1168205 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1168220..1168239 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1168231 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1168246..1168265) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1168250) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1168280..1168287) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1168285..1169097 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1168285..1169097 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1169076 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1169143..1169895) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1169143..1169895) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1169152) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1169895..1170647) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1169895..1170647) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1170767..1171741) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1170767..1171741) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1170802) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1171762..1171781) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1171788) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1171790..1174296) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1171796..1171803) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1171824..1171830 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1171845..1171863 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1171848 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1171873..1172370 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1171873..1172370 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1172371..1172484 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1172464..1172468 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1172484..1172503 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1172486..1172758 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1172486 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1172759..1173181 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1172759..1173181 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1173221..1174399 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1173221..1174399 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1174230..1174330 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1174288..1174306) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1174290 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1174296) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1174318..1174326) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1174398 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1174507..1174514 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1174529..1174548 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1174554 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1174597..1176018 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1174597..1176018 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1176086..1177465 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1176086..1177465 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1176605..1176624) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1176610) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1176638..1176645) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1177490 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1177500..1177507 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1177502..1177569 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1177570..1178583 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1177570..1178583 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1178589..1179608 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1178589..1179608 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1179633..1180712 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1179633..1180712 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1180709..1181545 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1180709..1181545 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1181593..1182861 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1181593..1182861 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1182805..1182808 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1182824..1182828 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1182826 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1182894..1182913 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1182894 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1182949..1183950 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1182949..1183950 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1183632..1183732) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1183672) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1183926 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1184027..1185469 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1184027..1185469 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1185466..1186959 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1185466..1186959 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1186998..1187762) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1186998..1187762) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1187017) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1187530,1187532) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1187789,1187796) /created_by="User" /modified_by="User" /label="TF8A" N_region 1187790..1187795 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1187798..1188118 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1187798..1188118 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1188127 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1188136..1188339) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1188155..1188292) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1188155..1188292) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1188179) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1188378..1188548) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1188378..1188548) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1188384) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1188548..1189294) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1188548..1189294) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1189129..1189148) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1189146) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1189164..1189171) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1189320..1189338) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1189333) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1189354..1189359) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1189404..1190405) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1189404..1190405) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1189433) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1190418..1191035) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1190418..1191035) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1191071..1191090) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1191073) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1191075..1191172) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1191106..1191110) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1191152..1191171) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1191172) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1191186..1191193) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1191217..1191236) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1191229) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1191311..1192627) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1191311..1192627) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1191326) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1192674..1192693) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1192690) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1192708..1192711) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1192910..1192917 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1192932..1192951 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1192944..1193015 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1192944 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1193016..1193966 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1193016..1193966 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1193954 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1194067..1194213 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1194067..1194213 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1194221..1196371 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1194221..1196371 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1195110..1195210 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1195170 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1195258 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1196383..1197354 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1196383..1197354 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1196711..1197352) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1197397) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1197422..1197788) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1197465) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1197768..1197783) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1197788) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1197795..1197804) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1197872..1199221) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1197872..1199221) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1197886) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1199261..1199268 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1199273..1199292) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1199281 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1199283..1199302 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1199291) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1199293..1199375) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1199303..1199310) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1199332..1199338 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1199353..1199372 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1199356 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1199358..1199377) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1199375) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1199390..1200208 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1199390..1200208 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1199393..1199396) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1200186 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1200265..1200272 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1200287..1200306 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1200291 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1200337..1201161 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1200337..1201161 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1201178..1202104 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1201178..1202104 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1202110..1203072 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1202110..1203072 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1202804..1202809 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1202825..1202843 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1202826 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1203077..1204084 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1203077..1204084 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1204087..1205736 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1204087..1205736 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1205730 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1205824..1206783 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1205824..1206783 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1206780..1207880 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1206780..1207880 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1207877..1208767 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1207877..1208767 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1208780..1209769 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1208780..1209769 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1209063..1209790) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1209759 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1209804..1210972 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1209812..1210861) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1209812..1210861) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1209835) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1210888..1210907) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1210899) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1210922..1210929) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1210951..1211811) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1210951..1211811) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1211836..1211854) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1211853) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1211870..1211876) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1211885..1211892 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1211906..1211925 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1211913 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1211971..1212489 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1211971..1212489 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1212480 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1212554..1212560 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1212572..1212678 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1212572 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1212574..1212585 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1212653..1212656 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1212672..1212691 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1212680 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1212728..1213927 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1212728..1213927 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1213916 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1213961..1214332 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1214004..1214228) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1214004..1214228) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1214308..1214314 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1214328..1214339 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1214334 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1214373..1215104 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1214373..1215104 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1215082 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1215143..1215151 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1215162..1215180 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1215170 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1215196..1215723 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1215196..1215723 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1215713..1216231 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1215713..1216231 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1216225..1216232 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1216246..1216265 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1216249 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1216264..1216375 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1216264..1216375 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1216338 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1216453..1216791 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1216453..1216791 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1216791..1217108 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1216791..1217108 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1217108..1217111 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1217127..1217146 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1217139 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1217179..1218081 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1217179..1218081 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1218072 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1218128..1218134 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1218140 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1218148..1218167 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1218169..1218379 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1218169..1218379 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1218337 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1218432..1219529 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1218432..1219529 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1218619..1218621 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1218623..1218627 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1218623 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1219541..1220788 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1219541..1220788 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1220779 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1220850..1220857 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1220872..1220891 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1220881 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1220914..1221339 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1220914..1221339 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1221328 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1221370..1221813) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1221370..1221813) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1221404) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1221840..1221859) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1221846) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1221874..1221877) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1221895..1221901 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1221915..1221933 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1221921 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1221956..1222366 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1221956..1222366 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1222344 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1222393..1222563 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1222393..1222563 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1222564..1223241 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1222613..1223083) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1222613..1223083) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1222637) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1223105..1223124) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1223121) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1223123..1223230) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1223140..1223143) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1223199 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1223256..1225544) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1223256..1225544) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1223275) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1225545..1225607) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1225567..1225667) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1225607) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1225672..1225827) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1225672..1225827) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1225673) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1225860..1225879) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1225872) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1225874..1225959) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1225895..1225902) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1225960..1226919) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1225960..1226919) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1226920..1226971) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1226964..1226983) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1226976) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1226997..1227003) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1227088..1227091 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1227104 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1227107..1227126 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1227142..1227975 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1227142..1227975 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1227951 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1228006..1228770) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1228006..1228770) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1228027) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1228745..1230388) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1228745..1230388) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1230375..1230974) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1230375..1230974) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1230976..1231578) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1230976..1231578) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1231656) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1231675..1231787) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1231675..1231787) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1231788..1231791 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1231802..1231821) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1231807..1231826 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1231818 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1231823) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1231836..1231843) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1231889..1232575 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1231889..1232575 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1232579..1233943 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1232579..1233943 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1233940..1234620 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1233940..1234620 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1234649..1234654 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1234670..1234688 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1234673 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1234712..1235224 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1234712..1235224 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1235210 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1235255..1235261 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1235275..1235286 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1235276 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1235307..1235444 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1235307..1235444 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1235417 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1235503..1235510 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1235524..1235543 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1235526..1235845 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1235526 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1235558..1235711 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1235558..1235711 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1235823..1235832 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1235845..1235864 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1235847..1235948 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1235847 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1235949..1237304 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1235949..1237304 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1237295 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1237347..1237679) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1237347..1237679) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1237695..1237714) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1237705) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1237707..1238095) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1237730..1237735) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1237767..1237867 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1237827 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1237874..1238029 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1237874..1238029 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1238038..1238045 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1238052..1238069 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1238069 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1238080..1238099) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1238095) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1238113..1238119) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1238117..1238299 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1238117..1238299 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1238267 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1238324..1238332 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1238343..1238361 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1238349..1238431 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1238349 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1238432..1238896 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1238432..1238896 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1238881 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1238911..1240032) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1238911..1240032) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1239320..1239328 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1239342..1239361 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1239345..1240123 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1239345 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1240061..1240072) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1240081) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1240087..1240093) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1240124..1240675 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1240124..1240675 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1240643 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1240703..1241515) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1240703..1241515) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1241475..1241494) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1241489) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1241508..1241513) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1241616..1241622 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1241633..1241707 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1241633 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1241636..1241647 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1241708..1243402 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1241708..1243402 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1243415..1244428 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1243415..1244428 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1244413 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1244454..1246289) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1244454..1246289) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1244503) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1246293..1247228) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1246293..1247228) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1247199..1247210) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1247209) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1247225..1247231) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1247265..1249667) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1247265..1249667) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1247297) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1249515..1249717) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1249706..1249724) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1249717) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1249738..1249745) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1249784..1249791 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1249805..1249824 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1249817 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1249848..1250513 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1249848..1250513 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1250382..1250401) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1250399) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1250415..1250424) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1250508..1250515 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1250530..1250549 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1250543 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1250569..1250702 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1250569..1250702 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1250590..1251564 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1250590..1251564 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1250653 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1251552 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1251674..1251682 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1251696..1251704 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1251706 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1251709..1251795 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1251768..1251775 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1251789..1251808 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1251797 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1251828..1252583 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1251828..1252583 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1252580..1253725 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1252580..1253725 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1253726..1254885 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1253736..1253930) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1253736..1253930) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1253743) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1253973..1253984) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1253983) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1253999..1254005) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1254061..1254762) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1254061..1254762) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1254095) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1254763..1254843) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1254835..1254854) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1254843) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1254859..1254866 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1254868..1254875) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1254880..1254899 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1254887 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1254933..1255829 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1254933..1255829 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1255823 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1255934..1255938 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1255954..1255973 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1255958 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1256003..1257352 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1256003..1257352 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1257340 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1257401..1257407 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1257421..1257432 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1257429..1257496 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1257429 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1257497..1257652 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1257497..1257652 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1257655..1257831 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1257655..1257831 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1257721..1257821 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1257781 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1257827 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1257874..1258896) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1257874..1258896) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1257897) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1258941..1258960) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1258957) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1258972..1258978) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1259085..1259093 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1259101 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1259104..1259122 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1259149..1261365 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1259149..1261365 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1261140..1262080) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1261218..1261225 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1261240..1261259 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1261242 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1261362..1261859 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1261362..1261859 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1261860..1262099 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1261949..1262074 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1261949..1262074 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1262067 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1262108..1263169) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1262108..1263169) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1262125) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1263177..1264370) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1263177..1264370) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1263237 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1264457) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1264463..1264619) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1264463..1264619) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1264654..1264673) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1264655) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1264689..1264696) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1264699..1264702 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1264703..1265482) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1264703..1265482) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1264718..1264737 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1264727 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1265175..1265182 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1265195..1265214 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1265210 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1265217..1265534 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1265504..1265511 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1265512..1265531) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1265526..1265545 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1265526) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1265536 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1265547..1265554) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1265577..1266773 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1265577..1266773 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1266755..1266762 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1266777..1266796 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1266796 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1266812..1266912 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1266812..1266912 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1266911 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1266997..1268214 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1266997..1268214 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1268211..1268918 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1268211..1268918 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1268876..1269505 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1268876..1269505 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1269520..1270056 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1269520..1270056 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1269903..1270096) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1270056 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1270097..1270417) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1270097..1270417) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1270155) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1270418..1270507) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1270443..1270449 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1270464..1270482 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1270474 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1270475..1270559 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1270489..1270508) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1270506) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1270523..1270526) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1270533..1270540 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1270555..1270574 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1270561..1270619 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1270561 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1270617) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1270620..1270877 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1270620..1270877 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1270871 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1270963..1271394 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1270963..1271394 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" CDS complement(1271422..1272942) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" /label="kinD CDS" gene complement(1271422..1272942) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /label="kinD gene" downshifts complement(1271434) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1272143..1272149 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1272163..1272174 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1272169 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1272950..1272969) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1272971) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1273069..1273076 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1273091..1273110 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1273093 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="upshifts" CDS 1273135..1273572 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" /label="mhqR CDS" gene 1273135..1273572 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /label="mhqR gene" downshifts 1273555 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1273612..1274397) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" /label="motB CDS" gene complement(1273612..1274397) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /label="motB gene" downshifts complement(1273631) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(1274093) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1274369..1275181) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" /label="motA CDS" gene complement(1274369..1275181) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /label="motA gene" promotor_-10 complement(1275212..1275230) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1275228) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1275244..1275251) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1275319..1275541) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1275351) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1275564..1277663) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1275564..1277663) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1275586) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1277664..1277914) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1277874..1277974) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1277914) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1277950..1277955 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1277965 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1277971..1277989 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1278028..1279071 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1278028..1279071 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1279072..1279163 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1279140..1279144 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1279161..1279180 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1279165 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1279210..1279254 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1279210..1279254 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1279231 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1279276..1279383 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1279384..1280043 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1279384..1280043 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1280036..1280485 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1280036..1280485 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1280478..1281209 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1280478..1281209 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1281227..1281724 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1281227..1281724 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1281725..1282001 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1281959 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1281969) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1282038..1282282) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1282079) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1282283..1282639) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1282283..1282639) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1282670..1282689) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1282687) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1282724..1282742 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1282729 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1282808..1283554 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1282808..1283554 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1283609 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1283957..1283965 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1283979..1283998 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1283983 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1284035..1285234 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1284035..1285234 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1284117..1284123 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1284138..1284156 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1284144 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1285203..1285205 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285225..1285243 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1285237 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1285250..1285477 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1285250..1285477 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1285327..1285346) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1285335) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1285478..1285573 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1285574..1286272 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1285574..1286272 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1286225..1287051) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1286253..1286504 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1286253..1286504 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1286754..1286769 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1286777..1286988 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1286777 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1286953 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1287040..1287059) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1287062) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1287075..1287082) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1287127..1287134 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1287149..1287168 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1287151 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1287187..1287477 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1287187..1287477 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1287514..1287597) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1287557) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1287598..1287783) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1287598..1287783) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1287816..1287835) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1287827) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1287829..1288173) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1287849..1287856) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1287882..1287887 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1287903..1287922 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1287910 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1287949..1288143 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1287949..1288143 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1288119 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1288164..1288182) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1288180) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1288199..1288204) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1288442..1289068 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1288442..1289068 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1288999 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1289125..1289130 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1289137 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1289146..1289164 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1289186..1290523 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1289186..1290523 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1290574..1291071 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1290574..1291071 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1290920..1290926 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1290935 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1290941..1290959 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1291045 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1291166..1291172 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1291183..1291202 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1291195 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1291199..1291306 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1291307..1293220 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1291307..1293220 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1291456..1291475) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1291473) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1291488..1291497) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1291624..1291643) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1291649) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1291657..1291663) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1293201 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1293277) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1293488..1293507) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1293497) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1293521..1293528) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1293572..1293591 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1293582 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1293627..1294718 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1293627..1294718 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1294367 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1294697 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1294731..1294949) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1294742..1294999 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1294936..1294955) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1294949) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1294971..1294978) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1295000..1295965 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1295000..1295965 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1295983..1295990 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1296005..1296024 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1296017 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1296028..1296894 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1296028..1296894 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1296749..1296753 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1296770..1296789 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1296778 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1296896 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1296941..1297092 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1296941..1297092 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1296941..1297092 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1297070..1297076 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1297090..1297101 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1297094 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1297123..1299222 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1297123..1299222 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1299240..1299244 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1299260..1299279 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1299271 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1299320..1299586 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1299320..1299586 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1299586..1301298 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1299586..1301298 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1301285 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1301338..1301344 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1301359..1301370 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1301362 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1301389..1301628 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1301389..1301628 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1301409..1302748) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1301706..1302734 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1301706..1302734 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1302704 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1302749..1303429) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1302749..1303429) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1303439..1303458) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1303462) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1303473..1303480) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1303514..1303521 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1303535..1303553 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1303541 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1303564..1305531 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1303564..1305531 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1304004..1304019) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1304016) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1305502 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1305575..1305577 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1305593..1305612 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1305603 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1305645) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1305669..1306535 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1305669..1306535 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1306515 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1306574..1307347) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1306574..1307347) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1306591) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1307379..1307398) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1307389) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1307622..1307641 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1307635 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1307637..1307740 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1307684..1309798 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1307684..1309798 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1308977..1308995) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1308989) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1309011..1309016) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1309779 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1309871..1309879 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1309891..1309909 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1309903 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1309962..1311782 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1309962..1311782 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1311793..1312974) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1311793..1312974) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1311827) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1313002..1313021) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1313018) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1313050..1313068) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1313062) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1313064..1313132) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1313083..1313088) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1313126..1313145) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1313132) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1313176..1313337) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1313176..1313337) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1313360..1313379) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1313373) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1313393..1313400) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1313474..1313481 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1313493 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1313494..1313512 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1313541..1314452 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1313541..1314452 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1313546) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1313995..1314003 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1314017..1314034 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1314020 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1314437 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1314496..1314960) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1314496..1314960) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1314514) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1314990..1315009) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1315000) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1315024..1315031) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1315086..1316378) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1315086..1316378) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1315108) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1316402..1316421) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1316406) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1316437..1316441) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1316454..1316948) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1316454..1316948) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1316964..1316983) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1316980) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1316997..1317006) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1317005..1317865) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1317005..1317865) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1317886..1317905) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1317899) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1317936..1317943 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1317959..1317978 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1317972 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1318008..1318772 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1318008..1318772 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1318773..1318921 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1318902..1318920 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1318923..1319072 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1318923 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1318970) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1319073..1320803 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1319073..1320803 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1320869..1321387 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1320869..1321387 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1321385 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1321430..1321435 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1321448..1321467 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1321451 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1321483..1322031 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1321483..1322031 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1322032..1322183 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1322184..1323407 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1322184..1323407 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1323370..1323388) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1323380) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1323386 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1323403..1323408) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1323456..1323463 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1323475..1323576 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1323475 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1323478..1323497 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1323493..1323576 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1323493..1323576 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1323533 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1323587..1323592 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1323607..1323891 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1323607 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1323609..1323627 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1323868..1323874 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1323888..1323899 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1323893..1323980 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1323893 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1323969..1323988 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1323982 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1324053..1324292 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1324053..1324292 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1324293..1324401 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1324402..1324920 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1324402..1324920 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1324957..1324964 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1324978..1324997 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1324992 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1325054..1325251 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1325054..1325251 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1325247 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1325292..1325388 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1325389..1325832 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1325389..1325832 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1325833..1325940 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1325908..1325913 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1325928..1325947 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1325942 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1325981..1326862 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1325981..1326862 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1326841 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1326897..1326904 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1326919..1326938 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1326924 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1326974..1327450 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1326974..1327450 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1327440..1328333 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1327440..1328333 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1328349..1328804 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1328349..1328804 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1328620..1328639) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1328633) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1328653..1328661) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1328798 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1328843..1328850 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1328864..1328883 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1328865 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1328909..1329619 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1328909..1329619 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1328918) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1329028..1329032) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1329028) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1329689..1330813 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1329689..1330813 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1330825..1330831 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1330845..1330856 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1330847 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1330851..1330865) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1330875..1330879) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1330875..1331120 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1330875..1331120 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1330876) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1331108 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1331153..1332103 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1331157..1331960) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1331157..1331960) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1331169) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1332011..1332030) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1332020) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1332044..1332051) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1332076..1332083 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1332098..1332117 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1332105..1332196 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1332105 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1332197..1332739 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1332197..1332739 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1332811..1333257 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1332811..1333257 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1333265 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1333650..1333657 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1333670 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1333672..1333691 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1333723..1334298 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1333723..1334298 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1334276 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1334339..1335304) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1334339..1335304) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1334352) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1334648..1334649 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1334667..1334686 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1334673..1335397 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1334673 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1335325..1335343) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1335346) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1335358..1335363) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1335384..1335390 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1335400 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1335404..1335423 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1335441..1336040 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1335441..1336040 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1336091..1337110 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1336091..1337110 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1337128..1338420 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1337128..1338420 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1338381..1338902 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1338381..1338902 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1338902..1339375 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1338902..1339375 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1339368..1339601 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1339368..1339601 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1339580 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1339646..1339651 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1339668..1339686 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1339676 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1339688..1339774 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1339764..1339767 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1339776 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1339782..1339801 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1339825..1341582 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1339825..1341582 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1341594..1343408 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1341594..1343408 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1342031..1342050) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1342041) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1342065..1342072) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1343459..1343468 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1343480..1343495 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1343484 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1343518..1344213 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1343518..1344213 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1344218..1345351 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1344218..1345351 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1345352..1346044 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1345352..1346044 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1346041..1347234 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1346041..1347234 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1347212 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1347283..1347289 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1347303..1347314 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1347311 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1347356..1347363 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1347378..1347397 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1347383..1347474 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1347383 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1347438..1347445 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1347459..1347478 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1347476 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1347514..1348269 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1347514..1348269 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1347662) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1347664..1347666) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1348266..1349177 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1348266..1349177 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1349192..1351099 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1349192..1351099 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1351084 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1351168..1351175 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1351186..1351205 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1351189 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1351244..1351825 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1351244..1351825 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1351810 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1351854 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1351859..1352128) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1351859..1352128) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1351864) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1352129..1352194) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1352175..1352194) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1352194) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1352247..1352254 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1352265..1352284 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1352269 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1352309..1353931 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1352309..1353931 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1353919 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1353988..1354899 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1353988..1354899 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1354904 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1354933..1356165) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1354933..1356165) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1354944) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1356183..1356202) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1356207) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1356217..1356222) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1356275..1356409) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1356275..1356409) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1356286) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1356431..1356449) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1356442) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1356444..1356509) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1356465..1356470) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1356510..1357517) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1356510..1357517) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1357563) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1357564..1357572) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1357586..1357594) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1357704..1357713 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1357725 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1357726..1357741 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1357728..1357800 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1357801..1358079 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1357801..1358079 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1358077 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1358111..1359740) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1358122..1358226 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1358134) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1358208..1358215 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1358227..1358246 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1358228 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1358269..1359555 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1358269..1359555 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1359571..1360404 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1359571..1360404 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1359737..1359755) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1359752) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1359771..1359776) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1360467..1361132 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1360467..1361132 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1361116 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1361223..1361229 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1361244..1361263) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1361244..1361263 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1361256 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1361258) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1361287..1363020 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1361287..1363020 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1362415..1363019) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1363009 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1363054..1364721) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1363054..1364721) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1363064) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1364727..1364936) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1364727..1364936) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1364973..1364992) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1364995) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1364997..1365174) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1365007..1365010) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1365175) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1365177..1365188) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1365202..1365208) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1365247..1365254 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1365268..1365287 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1365284 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1365322..1366095 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1365322..1366095 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1366066 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1366131..1366685) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1366131..1366685) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1366142) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1366707..1366726) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1366717) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1366741..1366748) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1366770 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1366794) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1366795..1366953) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1366795..1366953) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1366860..1367003) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1366860..1367003) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1366949..1366953 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1366954..1367022) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1366963..1366977 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1366990 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1367006..1367025) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1367035) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1367038..1367047) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1367109..1367116 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1367130..1367149 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1367134 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1367167..1367838 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1367167..1367838 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1367506..1367515 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1367528..1367546 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1367540 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1367785 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1368013..1368018 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1368035..1368054 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1368036..1368261 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1368036 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1368040..1368059) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1368056) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1368160..1368168) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1368166) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1368182..1368190) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1368262..1369377 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1368262..1369377 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1369381..1370358 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1369381..1370358 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1370359..1370472 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1370393..1370412) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1370410) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1370427..1370430) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1370473..1371801 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1370473..1371801 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1370617..1370624 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1370639..1370658 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1370642 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1371806..1373218 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1371806..1373218 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1373215 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1373263..1373637) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1373263..1373637) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1373311) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1373668..1373687) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1373678) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1373841..1373846 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1373862..1373880 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1373872 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1373876..1373985 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1373908) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1373969..1373976 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1373987 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1373991..1374010 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1374006..1374216 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1374006..1374216 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1374056..1374175 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1374056..1374175 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1374062) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1374162 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1374207..>1375806 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1374215..1375687) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1374215..1375687) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1374233) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1375688..1375783) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1375766..1375785) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1375783) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1375790..1375793 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1375800..>1375806) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 1375806..1375807 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_019" CDS 1376004..1377944 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1376004..1377944 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1377934..1378203 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1377934..1378203 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1378169..1378173 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1378187..1378206 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1378200 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1378203..1378724 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1378203..1378724 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1378721..1379014 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1378721..1379014 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1379054..1379665) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1379054..1379665) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1379068) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1379697..1379716) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1379706) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1379731..1379734) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1379921) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1379938..1380126) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1379938..1380126) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1379992) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1380148..1380167) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1380165) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1380180..1380187) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1380193..1380212 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1380200 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1380239..1382077 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1380239..1382077 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1382134..1382451 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1382134..1382451 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1382425 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1382500) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1382507..1382716) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1382507..1382716) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1382730..1382749) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1382745) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1382799..1383428) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1382799..1383428) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1382830) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1383330..1383348) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1383336) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1383360..1383368) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1383463..1383474) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1383468) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1383480..1383485 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1383489..1383495) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1383501..1383519 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1383501 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1383502..1383582 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1383583..1384911 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1383583..1384911 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1384767..1384914) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1384810) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1384912..1385502 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1384915..1385400) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1384915..1385400) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1385412..1385431) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1385440) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1385446..1385453) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1385503..1386432 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1385503..1386432 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1386017..1386036 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1386026 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1386456..1386459 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1386474..1386493 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1386482 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1386530..1386811 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1386530..1386811 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1386800 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1386874..1386877 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1386890..1387016 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1386890 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1386895..1386901 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1387017..1388228 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1387017..1388228 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1388238..1388242 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1388257..1388276 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1388276 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1388303..1391749 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1388303..1391749 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1391315..1391333) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1391335) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1391349..1391354) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1391729 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1391774 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1391806) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1391818 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1392152..1393072) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1392152..1393072) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1392158) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1393112..1393131) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1393127) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1393145..1393152) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1393207..1393214 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1393228..1393247 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1393229..1393334 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1393229 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1393336..1393426 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1393336 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1393342..1393345 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1393360..1393376 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1393427..1394344 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1393427..1394344 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1394373 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1394392 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1394393..1394398 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1394452..1394457 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1394472..1394490 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1394480..1394583 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1394480 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1394584..1395654 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1394584..1395654 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1395687..1397555 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1395687..1397555 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1397555..1398178 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1397555..1398178 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1398181..1398513 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1398181..1398513 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1398540..1399433 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1398540..1399433 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1399408 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1399465..1399827) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1399465..1399827) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1399484) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1399820..1399824 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1399833..1399846 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1399851..1399870) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1399855..1399966 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1399855 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1399863) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1399885..1399892) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1399967..1400413 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1399967..1400413 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1399999..1400006 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1400018..1400037 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1400023 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1400422..1400429 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1400443..1400462 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1400454 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1400497..1401537 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1400497..1401537 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1401460..1401478) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401465) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1401494..1401499) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1401517 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1401701..1401710 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1401724..1401743 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1401738 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1401769..1402167 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1401769..1402167 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1401773) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1402183..1402422 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1402183..1402422 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1402401 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1402489..1402496 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1402507..1402526 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1402512 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1402538..1402987 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1402538..1402987 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1402973 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1403042..1403314 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1403042..1403314 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1403119..1403342) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1403317..1403437 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1403317..1403437 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1403344..1403467) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1403387) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1403438..1403543 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1403468..1403480) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1403475) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1403495..1403501) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1403524..1403528 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1403544..1403563 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1403545..1403636 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1403545 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1403637..1404191 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1403637..1404191 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1404196..1404681 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1404196..1404681 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1404648 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1404692..1405918) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1404692..1405918) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1404693..1405967 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1405919..1406020) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1405942..1405949 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1405961..1405980 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1405969..1406098 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1405969 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1406015..1406033) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1406030) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1406050..1406055) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1406099..1406881 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1406099..1406881 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1406661..1406667 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1406681..1406692 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1406692 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1406883..1407908 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1406883..1407908 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1407792 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1407925..1409172) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1407925..1409172) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1407952) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1409089..1409095 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1409109..1409120 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1409113 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1409169..1409354) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1409169..1409354) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1409187..1409191 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1409207..1409226 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1409216..1409351 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1409216 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1409245..1409264) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1409255) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1409278..1409285) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1409322..1409329 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1409343..1409362 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1409353 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1409382..1409900 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1409382..1409900 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1409922..1410101 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1409922..1410101 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1410081 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1410124) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1410128..1410131) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1410182..1410187 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1410203..1410221 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1410204 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1410247..1410828 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1410247..1410828 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1410829 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1410885..1411367) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1410885..1411367) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1410904) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1411357 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1411390..1411409) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1411409) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1411423..1411430) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1411467..1411473 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1411485..1411504 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1411487 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1411527..1412423 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1411527..1412423 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1412494..1414113 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1412494..1414113 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1414085 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1414147..1414150 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1414165..1414238 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1414165..1414184 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1414165 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1414222) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1414239..1414670 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1414239..1414670 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1414740..1415675 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1414740..1415675 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1415342..1416794) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1415715..1416068 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1415715..1416068 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1416065..1418215 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1416065..1418215 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1416775..1416793) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1416794) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1416808..1416814) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1418198 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1418270..1418275 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1418291..1418309 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1418291 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1418332..1420272 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1418332..1420272 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1420068..1420074 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1420089..1420097 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1420095 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1420245 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1420290..1420357 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1420327..1420331 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1420347..1420366 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1420359..1420447 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1420359 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1420448..1421932 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1420448..1421932 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1421933..1422043 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1422044..1423018 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1422044..1423018 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1423019..1424374 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1423019..1424374 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1424198..1424203 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1424219..1424237 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1424229 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1424435..1425535 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1424435..1425535 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1425536..1425657 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1425658..1426749 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1425658..1426749 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1426138..1426147 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1426160..1426175 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1426165 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1426171..1426271 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1426231 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1426781..1427692 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1426781..1427692 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1427710 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1427822..1428613 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1427822..1428613 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1428610..1429305 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1428610..1429305 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1429328..1430035 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1429328..1430035 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1430053..1430418 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1430053..1430418 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1430270..1430273 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1430289..1430308 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1430305 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1430419..1430591 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1430592..1431914 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1430592..1431914 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1430799) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1430803..1430807) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1430822..1430826) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1431950..1433098 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1431950..1433098 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1433072 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR join(1433193,1433200) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs20" N_region 1433194..1433199 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs20" S_feature <1433200..1433245 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1433210..1433217 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1433230..1433249 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1433247 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1433304..1434098 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1433304..1434098 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1434016..1434019 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1434034..1434053 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1434042 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1434111..1434212 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1434111..1434212 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1434199 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1434300..1435580 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1434300..1435580 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1435521..1435537) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1435526) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1435601..1435606 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1435622..1435640 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1435626 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1435663..1435908 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1435663..1435908 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1435824..1435832 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1435843..1435861 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1435851 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1435909..1436019 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1436011..1436030 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1436021 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1436071..1436907 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1436071..1436907 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1436914..1437606 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1436914..1437606 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1437603..1438058 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1437603..1438058 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1438065..1438337 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1438065..1438337 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1438326 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1438398..1439171 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1438398..1439171 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1438887..1438894 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1438908..1438926 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1438931 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1439172..1439264 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1439265..1439759 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1439265..1439759 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1439772..1439779 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439793..1439812 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439800 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1439822..1440048 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1439822..1440048 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1440015 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1440101..1442866 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1440101..1442866 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1442857 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1442912) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1442947..1442953 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1442968..1442979 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1442968 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1443011..1443385 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1443011..1443385 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1443417..1443421 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1443436 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1443437..1443456 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1443488..1443952 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1443488..1443952 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1443954..1444865 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1443954..1444865 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1444860..1444867 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1444882..1444901 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1444896 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1444905..1445021 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1444905..1445021 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1445048..1445593 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1445048..1445593 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1445242) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1445584 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1445597..1445714 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1445597..1445714 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1445767..1447074 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1445767..1447074 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1447075..1447189 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1447075..1447189 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1447220..1448134 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1447220..1448134 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1448118..1449404 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1448118..1449404 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1449401..1450495 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1449401..1450495 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1450480..1453695 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1450480..1453695 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1453692..1454462 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1453692..1454462 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1454462..1455397 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1454462..1455397 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1455366..1456085 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1455366..1456085 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1456064..1456714 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1456064..1456714 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1456716 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1456761..1456833 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1456813..1456820 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1456834..1456853 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1456835 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1456859..1456964 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1456859..1456964 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1456965..1457125 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1457126..1457827 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1457126..1457827 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1457839..1458903 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1457839..1458903 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1458952..1460100 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1458952..1460100 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1459041) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1459053..1459057) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1459075..1459076) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1460113..1460706 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1460113..1460706 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1460707..1460804 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1460805..1461578 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1460805..1461578 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1461483..1461490 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1461505..1461524 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1461506 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1461581..1462366 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1461581..1462366 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1462347..1462835 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1462347..1462835 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1462815 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1462862) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1462875..1464593) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1462875..1464593) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1464615..1464634) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1464629..1464634 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1464629) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1464647..1464652) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1464650..1464668 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1464654 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1464709..1467381 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1464709..1467381 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1466114..1466133) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1466125) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1466148..1466155) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1467387..1467406 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1467390..1467463 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1467390 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1467464..1468339 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1467464..1468339 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1468416..1468685 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1468416..1468685 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1468496..1468500) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1468501) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1468693..1469307 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1468693..1469307 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1469311..1469514 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1469311..1469514 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1469503 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1469595..1470815 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1469595..1470815 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1470654..1471229) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1470812..1473229 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1470812..1473229 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1471225..1471243) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1471229) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1471257..1471263) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1473080..1473084 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1473100..1473119 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1473111 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1473256..1473738 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1473256..1473738 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1473743..1474696 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1473743..1474696 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1474683..1476026 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1474683..1476026 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1476030..1477121 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1476030..1477121 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1477128..1477892 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1477128..1477892 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1477181 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1477886..1479832 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1477886..1479832 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1479741..1479747 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1479761..1479779 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1479777 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1479847..1480743 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1479847..1480743 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1480748..1481401 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1480748..1481401 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1481399..1481408 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1481422..1481441 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1481427 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1481474..1482118 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1481474..1482118 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1481879..1481885 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1481896 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1481900..1481918 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1482009..1482014 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1482030..1482048 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1482043 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1482119..1482189 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1482190..1482270 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1482190..1482270 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1482285 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1482330..1482702 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1482343..1482531) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1482343..1482531) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1482359) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1482405) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1482532..1482624) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1482606..1482625) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1482624) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1482641..1482644) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1482675..1482682 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1482697..1482715 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1482704 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1482743..1482746 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1482761..1482780 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1482769 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1482808..1483170 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1482808..1483170 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1483021) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1483186..1484847 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1483186..1484847 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1484848..1484937 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1484910..1484917 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1484931..1484950 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1484939 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1484986..1485648 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1484986..1485648 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1485674..1486576 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1485674..1486576 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1486554..1488602 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1486554..1488602 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1488638..1488645 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1488660..1488679 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1488666 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1488711..1489277 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1488711..1489277 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1489291..1490292 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1489291..1490292 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1490311..1491264 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1490311..1491264 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1491257..1491997 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1491257..1491997 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1492028..1492032 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1492048..1492067 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1492053 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1492081..1492314 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1492081..1492314 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1492295 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1492323..1492423 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1492383..1492453 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1492383 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1492454..1493203 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1492454..1493203 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1493175 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1493245..1493251 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1493263..1493282 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1493285 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1493304..1496864 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1493304..1496864 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1496798..1497868) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1496884..1497873 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1496884..1497873 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1497860 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1497910..1498395) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1497910..1498395) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1497913) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1498417..1498435) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1498433) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1498449..1498456) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1498498..1498504 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1498519..1498538 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1498521 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1498572..1498904 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1498572..1498904 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1498575) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1498918..1500258 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1498918..1500258 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1500259..1500363 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1500364..1500636 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1500364..1500636 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1500636..1500881 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1500636..1500881 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1500853 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1500898..1501002 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1501003..1501389 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1501003..1501389 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1501394..1501918 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1501394..1501918 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1501915..1502646 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1501915..1502646 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1502652..1502659 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1502673..1502692 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1502677 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1502725..1502766 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1502725..1502766 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1502786..1503133 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1502786..1503133 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1503135 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1503188..1503194 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1503207..1503275 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1503207 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1503208..1503227 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1503276..1504124 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1503276..1504124 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1504145..1504152 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1504165..1504183 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1504175 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1504195..1504962 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1504195..1504962 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1504994..1506724 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1504994..1506724 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1506231) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1506232..1506251) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1506266..1506273) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1506721..1507002 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1506721..1507002 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1506834 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1507003..1507122 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1507094..1507101 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1507115..1507134 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1507124 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1507175..1508332 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1507175..1508332 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1507247..1507347) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1507287) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1508361..1509263 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1508361..1509263 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1509253 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1509324..1510217 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1509324..1510217 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1510223..1510230 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1510245..1510264 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1510252..1510404 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1510252 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1510405..1512480 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1510405..1512480 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1512450 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1512512..1512517 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1512524 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1512533..1512551 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1512556..1513863 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1512556..1513863 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1513869..1513873 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1513890..1513909 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1513900 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1513931..1514845 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1513931..1514845 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1513970..1513974 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1513987 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1513990..1514009 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1514858..1515403 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1514858..1515403 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1515420..1516823 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1515420..1516823 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1516863..1517642 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1516863..1517642 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1517617 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1517661 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1517762..1517769 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1517782..1517800 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1517793..1517946 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1517793 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1517921..1517928 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1517943..1517962 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1517948 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1518022..1518411 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1518022..1518411 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1518411..1518863 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1518411..1518863 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" SCAR 1518864..1518865 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_004" CDS 1518920..1519684 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1518920..1519684 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1519694..1519700 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1519713..1520216 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1519713..1520216 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1519715..1519726 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1519729 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1520212..1520218 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1520233..1520252 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1520235..1520359 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1520235 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1520360..1521100 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1520360..1521100 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1521082 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1521127..1521201 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1521202..1522083 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1521202..1522083 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1522084..1522228 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1522229..1522951 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1522229..1522951 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1522953..1523510 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1522953..1523510 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1523457) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1523499..1523502 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1523517..1523536 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1523535..1523640 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1523535 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1523641..1524423 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1523641..1524423 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1524427..1525236 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1524427..1525236 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1525217..1525224 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1525239..1525258 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1525240 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1525298..1526449 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1525298..1526449 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1526456..1527724 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1526456..1527724 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1527757..1529451 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1527757..1529451 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1529452..1529559 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1529560..1533873 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1529560..1533873 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1533874..1533938 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1533884..1534101 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1533884..1534101 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1533910..1533916 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1533931..1533942 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1533940..1534007 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1533940 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1533990..1533996 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1534009..1534202 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1534009 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1534010..1534029 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1534203..1534673 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1534203..1534673 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1534524) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1534708..1535823 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1534708..1535823 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1534770..1534870) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1534810) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1535837..1536112 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1535837..1536112 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1536114..1536416 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1536114..1536416 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1536436..1538586 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1536436..1538586 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1538481..1538487 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1538496 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1538502..1538520 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1538583..1538861 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1538583..1538861 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1538878..1539231 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1538878..1539231 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1539222 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1539313..1540242 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1539313..1540242 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1540027..1540034 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1540048..1540067 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1540057 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1540261..1541211 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1540261..1541211 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1541244..1541250 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1541251..1541367 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1541251 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1541265..1541284 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1541368..1541637 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1541368..1541637 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1541620 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1541665..1541750 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1541731..1541734 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1541750..1541769 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1541752 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1541810..1543927 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1541810..1543927 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1543710 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1543911 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1543956..1544044 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1544045..1545004 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1544045..1545004 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1544113..1544121) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1544116) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1544135..1544142) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1544608..1544613 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1544629..1544647 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1544634 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1545044..1546273 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1545044..1546273 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1546262 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1546302..1546307 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1546317 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1546323..1546341 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1546351..1546608 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1546351..1546608 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1546609..1546663 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1546636 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1546705..1546714 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1546724..1546793 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1546724 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1546728..1546747 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1546794..1547687 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1546794..1547687 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1547690..1548292 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1547690..1548292 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1548346..1548365 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1548346..1548417 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1548346 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1548418..1549458 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1548418..1549458 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1549459..1549549 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1549550..1550764 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1549550..1550764 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1550795..1551667 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1550795..1551667 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1551138..1552322) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1551674 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1551767..1551770 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1551784 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1551786..1551805 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1551845..1553512 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1551845..1553512 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1552309..1552327) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1552326) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1552343..1552348) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1553500 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1553567..1553573 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1553587..1553598 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1553588 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1553628..1554365 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1553628..1554365 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1554362..1554574 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1554362..1554574 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1554602..1554621 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1554616 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1554705..1557068 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1554705..1557068 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1557069..1557169 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1557130..1557137 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1557152..1557171 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1557170 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1557212..1557937 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1557212..1557937 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1557924 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1557993..1557999 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1558012 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1558014..1558025 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1558076..1559284 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1558076..1559284 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1559242 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1559353..1559360 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1559373..1559392 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1559395 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1559407..1559410 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1559426..1559438 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1559440 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1559464..1560744 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1559464..1560744 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1560741..1562027 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1560741..1562027 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1561877 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1562028..1562081 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1562082..1562810 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1562082..1562810 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1562826..1562832 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1562844 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1562846..1562857 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1562857) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1562868..1562882) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1562891..1562895) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1562891..1563148 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1562891..1563148 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1563133 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1563165) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1563206..1563209 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1563224..1563243 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1563224 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1563278..1563793 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1563278..1563793 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1563729..1564067 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1563729..1564067 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1564134..1565000 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1564134..1565000 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1564197..1564297 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1564257 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1564960 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1565050..1565631 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1565050..1565631 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1565649..1566899 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1565649..1566899 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1566900..1567026 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1567006..1567013 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1567028..1567047 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1567028 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1567072..1568118 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1567072..1568118 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1568130 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1568175..1568240 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1568212..1568221 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1568234..1568249 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1568242 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1568286..1569461 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1568286..1569461 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1569462..1569561 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1569535..1569542 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1569556..1569575 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1569563..1569736 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1569563 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1569737..1571299 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1569737..1571299 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1571276 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1571368..1572162 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1571368..1572162 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1571917..1571922 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1571938..1571956 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1571958 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1572206..1572211 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1572222..1572361 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1572222 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1572227..1572245 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1572254) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1572265..1572278) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1572287..1572291) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1572298) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1572362..1572622 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1572362..1572622 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1572574 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1572606) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1572618 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1572663..1572837 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1572821..1572828 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1572839 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1572843..1572862 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1572888..1573931 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1572888..1573931 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1573944..1575122 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1573944..1575122 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1575104 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1575202..1575205 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1575214 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1575220..1575239 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1575270..1576799 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1575270..1576799 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1576801..1577232 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1576801..1577232 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1577215 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1577363..1577368 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1577384..1577402 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1577392..1577493 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1577392 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1577494..1578039 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1577494..1578039 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1578033 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1578040) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1578097..1578100 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1578115..1578134 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1578119 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1578172..1580748 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1578172..1580748 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1580764..1582647 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1580764..1582647 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1582550..1583044) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1582562 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1582572) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1582794..1582801 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1582816..1582835 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1582826..1582959 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1582826 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1582831..1582981) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" /label="surX RNA" gene complement(1582831..1582981) /gene="surX" /locus_tag="BSU_misc_RNA_89" /label="surX gene" downshifts 1582916 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" /label="downshifts" CDS complement(1583045..1583500) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" /label="ymzD CDS" gene complement(1583045..1583500) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /label="ymzD gene" S_feature complement(1583501..1583592) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1583580..1583599) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1583592) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1583616..1583619) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1583655..1584212) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" /label="ymcC CDS" gene complement(1583655..1584212) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /label="ymcC gene" SCAR 1584303..1584304 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs08" downshifts complement(1584355) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(1584361..1584717) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" /label="ymzB CDS" gene complement(1584361..1584717) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /label="ymzB gene" misc_feature complement(1584777..1584790) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1584782) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1584796..1585620) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" /label="ymaE CDS" gene complement(1584796..1585620) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /label="ymaE gene" promotor_-10 complement(1585642..1585661) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1585658) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1585673..1585679) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1585731..1587059) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" /label="aprX CDS" gene complement(1585731..1587059) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /label="aprX gene" downshifts complement(1585738) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1587082..1587101) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1587101) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1587115..1587123) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1587216..1587223 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1587231..1587250) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1587239..1587258 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1587242) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" upshifts 1587245 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1587263..1587270) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1587284..1587361 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" /label="ymzEn CDS" gene 1587284..1587361 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo /label="ymzEn gene" downshifts complement(1587286) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS 1587339..1587515 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" /label="ymzEc CDS" gene 1587339..1587515 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo /label="ymzEc gene" downshifts 1587496 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature 1587541..1587729 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1587724..1587743 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1587731 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1587795..1588502 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" /label="pghC CDS" gene 1587795..1588502 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /label="pghC gene" promotor_-35 1588513..1588519 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1588533..1588552 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1588537 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1588572..1589024 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" /label="ymaD CDS" gene 1588572..1589024 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /label="ymaD gene" downshifts 1589012 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1589038..1589391) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" /label="ebrB CDS" gene complement(1589038..1589391) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /label="ebrB gene" downshifts complement(1589079) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1589405..1589722) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" /label="ebrA CDS" gene complement(1589405..1589722) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /label="ebrA gene" promotor_-10 complement(1589766..1589785) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1589774) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1589800..1589807) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1589859..1590134) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" /label="ymaG CDS" gene complement(1589859..1590134) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /label="ymaG gene" downshifts complement(1589860) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1590130..1590135 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1590151..1590169 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1590161..1590180) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1590171 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1590174) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1590193..1590202) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1590223..1590636 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1590223..1590636 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1590687 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1590693..1590712 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1590736..1591680 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1590736..1591680 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1591660..1591668 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1591679..1591697 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1591681 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1591720..1591941 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1591720..1591941 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1591731) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1591793..1591797) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1591797) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1591812..1591817) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1591941 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1592137..1592409 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1592137..1592409 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1592425..1592432 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1592446..1592465 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1592448 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1592491..1592721 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1592491..1592721 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1592722..1592798 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1592755 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1592800..1592907 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1592880..1592887 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1592901..1592920 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1592909 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1592964..1593356 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1592964..1593356 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1593316..1595418 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1593316..1595418 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1595436..1596425 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1595436..1596425 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1596385 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1596439..1597098) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1596454) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1596475..1597095 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1596475..1597095 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1597076 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1597111..1597115 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1597133..1597500 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1597133 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1597137..1597154 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1597143) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1597159..1597926) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1597159..1597926) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1597935..1597954) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1597958) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1597967..1597976) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1598080..1598085 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1598101..1598119 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1598101 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1598383..1598388 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1598405..1598423 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1598409..1598549 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1598409 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1598550..1599518 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1598550..1599518 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1599487 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1599582..1599590 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1599597 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1599601..1599620 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1599651..1600913 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1599651..1600913 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1600931..1602196 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1600931..1602196 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1602244..1602251 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1602266..1602285 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1602278 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1602306..1602713 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1602306..1602713 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1602312) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1602694..1602712 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1602719 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1602772) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1602772..1604106 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1602772..1604106 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1604083 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1604128..>1604177 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" SCAR 1604177..1604178 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs04" S_feature <1604178..1604930 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1604270..1604288) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1604288) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1604304..1604309) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1604931..1606322 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1604931..1606322 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1606353..1607954 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1606353..1607954 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1606469..1606774) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1606769..1606788) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1606774) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1606802..1606810) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1607952 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1608091..1609245) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1608091..1609245) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1608094) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1609144..1609322) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1609290..1609296 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1609305..1609324) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1609306..1609322 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1609316 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1609322) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1609339..1609342) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1609349..1609356 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1609371..1609390 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1609382..1609486 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1609383 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1609487..1610824 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1609487..1610824 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1610825..1610899 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1610856 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1610975..1612474 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1610975..1612474 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1612475..1612790 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1612748 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1612957..1613592) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1612957..1613592) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1613629..1613648) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1613638) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1613663..1613670) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1613780..1613787 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1613802..1613821 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1613804..1614002 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1613804 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1614003..1615418 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1614003..1615418 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1615408 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1615511) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1615520..1616704) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1615520..1616704) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1616705..1616784) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1616777..1616795) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1616788) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1616811..1616816) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1617096..1617103 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1617118..1617137 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1617126 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1617168..1617629 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1617168..1617629 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1617659..1618093 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1617659..1618093 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1617842..1618147) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1617940 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1618094..1619190 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1618149..1618434) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1618192) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1618429..1618448) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1618434) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1618460..1618465) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1618696) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1618696..1618956) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1618696..1618956) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1618977..1618996) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1618987) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1619009..1619018) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1619191..1619316 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1619191..1619316 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1619317..1619433 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1619360..1619524 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1619360..1619524 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1619408..1619417 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1619431..1619450 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1619435..1619745 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1619435 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1619726..1619733 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1619747..1619766 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1619747 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1619798..1620637 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1619798..1620637 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1619820..1619839) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1619841) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1619854..1619857) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1620597 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1620743) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1620744..1621050) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1620760..1621047) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1620760..1621047) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1620787) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1620874..1620882 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1620896..1620915 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1620898 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1620909..1621069 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1621041 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1621090..1621812) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1621090..1621812) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1621095) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1621837..1621856) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1621845) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1621847..1621971) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1621972..1622328) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1621972..1622328) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1622352..1622371) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1622369) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1622387..1622391) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1622568) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1622574..1622774) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1622574..1622774) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1622757 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1622796..1622815) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1622808) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1622828..1622837) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1622949..1623137) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1622949..1623137) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1622965) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1623106..1623113) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1623119) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1623166..1623185) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1623184) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1623200..1623207) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1623216..1623353 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1623216..1623353 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1623247..1623252 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1623267..1623285 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1623285..1623387 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1623285 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1623388..1623786 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1623388..1623786 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1623787..1624591 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1623851..1624285) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1623851..1624285) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1623867) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1624315..1624334) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1624331) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1624348..1624355) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1624592..1624780 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1624592..1624780 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1624781..1624866 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1624825 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1624895..1624901 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1624913..1625072 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1624913 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1624915..1624926 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1625073..1626635 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1625073..1626635 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1625376..1625395) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1625385) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1625410..1625417) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1626665..1627756 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1626665..1627756 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1627746..1628960 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1627746..1628960 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1629038..1629045 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1629060..1629079 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1629071 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1629107..1629913 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1629107..1629913 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1629721..1630819) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1629918..1630535 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1629918..1630535 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1630532..1632172 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1630532..1632172 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1630806..1630825) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1630819) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1630839..1630847) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1631812..1632578) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1632209..1632574 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1632209..1632574 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1632551 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1632571..1632851) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1632571..1632851) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1632580..1632711) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1632623) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1632671..1632680 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1632693..1632702) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1632694..1632713 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1632699 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1632701..1632799 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1632711) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1632713..1632843) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1632800..1633558 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1632800..1633558 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1632833 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1632849..1632868) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1632850) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1632883..1632890) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1633373..1633584) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1633537 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1633582..1634201 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1633585..1634124) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1633585..1634124) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1634125..1634139) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1634131) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1634153..1634159) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1634179..1634188 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1634201..1634216 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1634203 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1634242..1634676 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1634242..1634676 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1634534..1634881 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1634534..1634881 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1634677..1635009 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1634968..1634977 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1634989..1635004 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1635011..1635189 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1635011 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1635080..1635159 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1635080..1635159 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1635146 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1635218..1635835) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1635218..1635835) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1635219) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1635859..1635878) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1635880) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1635892..1635899) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1635915..1635922 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1635934 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1635936..1635955 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1635985..1636302 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1635985..1636302 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1636002..1636020) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1636005) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1636034..1636041) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1636321..1636974 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1636321..1636974 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1636977..1636984 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1636998..1637017 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1637011 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1637038..1637271 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1637038..1637271 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1637272..1637407 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1637375..1637382 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1637396..1637415 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1637409 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1637440..1639443 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1637440..1639443 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1637644..1637663) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1637661) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1639433 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1639445..1640103) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1639543 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1639544..1639563 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1639596..1640042 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1639596..1640042 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1640066..1640085 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1640074 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1640085..1640102) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1640103) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1640121..1640125) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1640128..1640346 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1640128..1640346 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1640358 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1640403..1640702 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1640420..1640593) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1640420..1640593) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1640433) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1640631..1640650) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1640638) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1640664..1640671) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1640673..1640681 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1640693..1640712) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1640693..1640711 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1640704..1640812 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1640704 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1640705) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1640727..1640734) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1640813..1641520 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1640813..1641520 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1641540..1641547 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1641559..1641578 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1641567 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1641609..1641971 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1641609..1641971 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1641989..1641992 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1642007..1642026 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1642018 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1642050..1642541 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1642050..1642541 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1642537 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1642572..1643000) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1642572..1643000) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1642589) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1643018..1643037) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1643030) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1643032..1643117) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1643051..1643058) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1643088..1643097 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1643107..1643216 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1643107 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1643110..1643129 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1643112..1643131) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1643117) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1643119..1643202) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1643146..1643149) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1643173 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1643234..1643626) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1643234..1643626) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1643247) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1643469..1643474 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1643490..1643508 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1643494 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1643604..1643608 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1643618..1643632 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1643633..1643652) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1643635 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1643648) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1643666..1643675) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1643707..1643853) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1643707..1643853) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1643728) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1643885..1644031) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1643885..1644031) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1644031..1644164 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1644031 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1644042..1644044 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1644047..1644058) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1644061) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1644073..1644079) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1644154..1644161 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1644166..1644258 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1644166 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1644176..1644195 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1644217) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1644259..1646988 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1644259..1646988 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1644279..1644283) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1644283) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1646989..1647059 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1647060..1647572 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1647060..1647572 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1647529 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1647598..1647604 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1647617 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1647619..1647630 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1647653..1647778 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1647653..1647778 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1647671) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1647792..1647798 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1647813..1647824 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1647815 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1647843..1647989 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1647843..1647989 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1648026..1648277 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1648026..1648277 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1648255 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1648298..1648303 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1648317..1648336 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1648321..1648412 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1648321 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1648413..1648778 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1648413..1648778 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1648794..1649093 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1648794..1649093 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1649069 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1649124..1649411) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1649124..1649411) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1649145) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1649211) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1649441..1649460) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1649453) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1649476..1649483) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1649499..1650080) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1649499..1650080) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1650081..1650211 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1650106..1650125) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1650123) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1650196..1650199 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1650213 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1650215..1650234 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1650250..1650657 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1650250..1650657 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1650653 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1650719..1650722 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1650737..1650756 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1650741..1651055 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1650741 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1651056..1653023 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1651056..1653023 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1653027..1655447 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1653027..1655447 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1655427 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1655455..1655644) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1655494..1655670) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1655494..1655670) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1655498) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1655645..1656055) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1655645..1656055) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1656028..1656047) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1656031) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1656062..1656069) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1656096..1656115) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1656097) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1656130..1656137) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1656144..1656163) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1656155) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1656177..1656186) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1656403..1656408 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1656421..1656440 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1656426 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1656439..1656503 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1656504..1657901 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1656504..1657901 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1657890 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1657935 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1657991..1658737) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1658114..1658121 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1658133 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1658134..1658153 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1658204..1659703 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1658204..1659703 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1658736..1658755) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1658759) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1658769..1658778) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1659651 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1659771..1660034 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1659771..1660034 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1660293) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1660293..1661561) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1660293..1661561) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1661562..1661691) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1661692..1663233) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1661692..1663233) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1663234..1663555) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1663545..1663564) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1663556) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1663579..1663582) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1663782..1663789 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1663802..1663821 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1663809 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1663828..1664274 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1663828..1664274 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1664281..1665174 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1664281..1665174 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1664791..1664810 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1664799 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1665247..1665843 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1665247..1665843 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1665833 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1665892..1667091) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1665892..1667091) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1667092..1667163) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1667151..1667162) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1667163) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1667177..1667183) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1667261..1668796) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1667261..1668796) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1667273) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1668807..1669589) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1668807..1669589) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1669610..1670509) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1669610..1670509) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1670524..1670745) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1670524..1670745) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1670760..1672094) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1670760..1672094) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1672104..1673753) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1672104..1673753) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1672153..1672253 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1672213 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1673797..1674939) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1673797..1674939) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1674958..1674976) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1674975) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1674992..1674997) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1675030..1675335) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1675030..1675335) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1675325..1675498) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1675325..1675498) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1675606..1677138) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1675606..1677138) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1675617) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1677173..1677192) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1677173) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1677205..1677214) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1677274..1677666) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1677274..1677666) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1677305) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1677694..1677705) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1677701) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1677719..1677725) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1677773,1677780) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs10" N_region 1677774..1677779 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs10" S_feature complement(<1677780..1677885) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1677870..1677889) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1677885) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1677903..1677910) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1678159..1679634) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1678159..1679634) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1678171) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1679668..1680645) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1679668..1680645) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1680674..1680692) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1680686) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1680704..1680712) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1680779..1682170) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1680779..1682170) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1680793) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1680939 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1681960..1681966 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1681980..1681998 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1681991..1682324 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1681991 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1682171..1682275) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1682235..1682335) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1682275) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1682297..1682302 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1682318..1682336 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1682326 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1682384..1682391 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1682404..1682423 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1682407 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1682456..1683001 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1682456..1683001 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1682985 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1683095..1683167) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1683095..1683167) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1683193) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1683220..1683765) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1683220..1683765) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1683805..1683824) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1683819) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1683838..1683845) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1684081..1684311) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1684081..1684311) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1684095) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1684337..1684356) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1684349) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1684368..1684374) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1684403..1684422) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1684413) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1684426..1684433 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1684447..1684466 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1684451 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1684496..1686259 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1684496..1686259 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1686240 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1686360..1687217) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1686360..1687217) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1687263..1687282) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1687283) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1687296..1687303) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1687345..1688334 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1687345..1688334 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1687401..1688359) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1688391..1689872) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1688391..1689872) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1688404) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1689889..1694451) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1689889..1694451) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1692912..1693012 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1692972 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1694452..1694523) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1694503..1694522) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1694520..1694527 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1694523) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1694537..1694544) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1694539 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1694542..1694561 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1694598..1695500 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1694598..1695500 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1695480 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1695552..1696667) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1695552..1696667) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1696664..1697557) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1696664..1697557) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1697562..1697581) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1697570 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1697580) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1697595..1697601) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1697610..1697628) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1697628) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1697644..1697649) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1697705..1698073) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1697705..1698073) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1698108..1698126) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1698131) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1698133..1698252) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1698138..1698146) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1698244..1698263) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1698252) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1698254..1698350) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1698278..1698285) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1698373..1699089) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1698373..1699089) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1698395) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1699127..1699146) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1699136) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1699162..1699165) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1699190..1699196 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1699210..1699228 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1699215 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1699240..1699545 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1699240..1699545 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1699529 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1699616..1700386 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1699616..1700386 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1700368..1700375 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1700387 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1700390..1700409 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1700430..1700963 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1700430..1700963 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1700964..1701049 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1701006 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1701042..1702286) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1701042..1702286) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1701051..1701790 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1701056) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1702287..1702379) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1702380..1703843) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1702380..1703843) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1703861..1704895) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1703861..1704895) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1704907..1704978) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1704950) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1704979..1705070) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1704979..1705070) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1705098..1705117) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1705110) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1705132..1705139) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1705152..1705159 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1705173..1705192 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1705177 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1705219..1707261 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1705219..1707261 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1707269..1707278 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1707291..1707306 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1707294 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1707328..1707621 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1707328..1707621 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1707601 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1707646..1707993) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1707677) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1707994..1708398) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1707994..1708398) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1708399..1708494) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1708484..1708499) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1708484..1708603) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1708484..1708603) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1708494) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1708512..1708521) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1708599..1708605 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1708619..1708630 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1708630..1708838 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1708630 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1708673..1708795 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1708673..1708795 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1708839..1709132 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1708839..1709132 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1709133..1709226 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1709183 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1709248..1710933) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1709248..1710933) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1709260) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1710934..1711021) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1711013..1711031) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1711021) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1711045..1711052) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1711190..1711199 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1711209 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1711212..1711231 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1711258..1712709 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1711258..1712709 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1712685 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1712746..1713444) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1712746..1713444) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1712761) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1713479..1713498) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1713498) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1713500..1713713) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1713512..1713519) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1713714..1714391) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1713714..1714391) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1714392..1716881) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1714564..1715601 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1714564..1715601 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1715798..1715804 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1715819..1715830 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1715831 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1715858..1716541 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1715858..1716541 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1716882..1717187) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1716882..1717187) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1717188..1717289) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1717268..1717287) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1717289) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1717302..1717309) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1717317..1717419) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1717359) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1717420..1718598) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1717420..1718598) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1718624..1718643) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1718643) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1718657..1718666) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1718721..1719209) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1718721..1719209) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1718746) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1719234..1719389) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1719234..1719389) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1719429..1720184) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1719429..1720184) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1720437..1720442 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1720458..1720476 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1720473 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1720492..1720848 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1720492..1720848 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1720807..1721046) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1720807..1721046) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1720849..1721285 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1721047..1721148) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1721149..1721646) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1721149..1721646) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1721647..1721746) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1721747..1722658) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1721747..1722658) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1722680..1722691) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1722682) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1722706..1722712) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1722942..1722949 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1722958 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1722964..1722983 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1723005..1723487 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1723005..1723487 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1723497..1723751 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1723497..1723751 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1723752..1723856 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1723857..1724651 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1723857..1724651 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1724652..1725662 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1724775..1725647) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1724775..1725647) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1725748..1726626 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1725748..1726626 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1726739..1726798) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1726774) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1726799..1727230) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1726799..1727230) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1727250..1727269) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1727258) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1727260..1727493) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1727283..1727289) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1727494..1727512) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1727494..1728126) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1727494..1728126) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1727500) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1727528..1727533) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1728264..1728271 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1728286..1728305 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1728290 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1728352..1729272 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1728352..1729272 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1728783..1728802) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1728798) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1728817..1728824) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1729273..1729930 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1729769..1730131) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1729769..1730131) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1730192..1730404) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1730192..1730404) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1730443..1730450 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1730465..1730484 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1730468 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1730508..1730771 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1730508..1730771 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1730749 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1731148..1733748) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1731148..1733748) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1733749..1733858) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1733774..1733781 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1733796..1733815 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1733804..1734431 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1733804 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1733848..1733867) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1733858) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1733882..1733888) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1733904..1734363) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1733946) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1734408) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1734418..1735059) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1734418..1735059) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1735060..1735177) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1735154..1735173) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1735177) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1735187..1735189) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1735265,1735272) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs05" N_region 1735266..1735271 /note="SacI site (GAGCTC)" /modified_by="User" /label="IIG_Bs05" misc_RNA <1735272..1735356 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" S_feature <1735272..1735349 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" S_feature complement(<1735272..1735336) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" gene <1735272..1735356 /gene="bsrF" /old_locus_tag="BSU_misc_RNA_75" /locus_tag="PG10_pseudo_BSU_misc_RNA_75" /modified_by="User" /label="PG10_pseudo_BSU_misc_RNA_75" downshifts 1735334 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1735367..1735699) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1735367..1735699) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1735381) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1735764..1736489) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1735764..1736489) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1736504..1737247) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1736504..1737247) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1737275..1737294) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1737294) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1737308..1737314) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1737325..1737900) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1737325..1737900) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1737906..1738607) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1737906..1738607) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1738637..1738656) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1738637) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1738641..1738656) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1738671..1738678) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1738671..1738678) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1738681) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1738684..1739166) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1738684..1739166) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1739205..1739222) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1739209) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1739220..1740161) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1739220..1740161) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1739253) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1740191..1740210) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1740199) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1740224..1740228) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1740232..1740241 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1740254..1740273 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1740262 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1740277..1740341 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1740313..1740318 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1740334..1740352 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1740343 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1740367..1740912 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1740367..1740912 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1740871 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1740939..1741262) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1740939..1741262) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1740946) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1741283..1741302) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1741294) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1741315..1741322) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1741383..1741389 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1741400 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1741404..1741423 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1741456..1742133 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1741456..1742133 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1742125 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1742223..1742759) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1742223..1742759) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1742246) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1742786..1742805) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1742806) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1742819..1742826) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1742896..1743678) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1742896..1743678) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1742905) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1743700..1743718) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1743719) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1743732..1743738) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1743775..1743782 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1743797..1743816 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1743801 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1743849..1744346 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1743849..1744346 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1744353..1744356 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1744372..1744391 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1744374 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1744410..1745387 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1744410..1745387 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1745359 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1745484..1745491 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1745506..1745525 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1745513 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1745549..1746607 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1745549..1746607 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1746608..1746677 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1746661..1746667 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1746679..1746698 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1746679 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1746727..1747839 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1746727..1747839 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1747858..1748457 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1747858..1748457 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1748395 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1748439 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1748479..1748977) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1748515) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1748949..1748958 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1748961..1748979) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1748970..1749164 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1748970 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1748971..1748990 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1748977) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1748996..1749001) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1749052..1749915) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1749052..1749915) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1749065) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1749121 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1749153) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1749166..1749933 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1749911..1749915 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1749924..1749938 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1749935 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1749954..1749973) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1749967) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1749969..1750162) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1749985..1749991) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1750163..1751938) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1750163..1751938) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1751939..1752069) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1752062..1752264) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1752062..1752264) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1752114) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1752262..1752281) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1752280) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1752282..1752474) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1752294..1752301) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1752503..1753129) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1752503..1753129) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1752519) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1753163..1753182) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1753176) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1753196..1753203) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1753280..1753771) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1753280..1753771) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1753289) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1753783..1753801) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1753795) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1753815..1753821) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1753846..1754178) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1753846..1754178) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1754179..1754469) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1754194..1754199 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1754214..1754232 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1754216 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1754256..1754483 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1754256..1754483 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1754470..1754946) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1754470..1754946) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1754484..1754991 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1754947..1755049) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1754964..1754969 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1754984..1755002 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1754993 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1755013..1755276 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1755013..1755276 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1755029..1755048) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1755049) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1755051..1755576) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1755062..1755066) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1755281..1755514 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1755281..1755514 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1755501 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1755600..1755944) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1755600..1755944) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1755621) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1755945..1756017) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1756013..1756032) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1756017) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1756019..1756122) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1756046..1756051) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1756109..1756124) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1756122) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1756137..1756146) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1756265) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1756301..1756504) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1756301..1756504) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1756525..1756544) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1756543) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1756545..1756611) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1756560..1756567) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1756577..1756584 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1756596 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1756598..1756610) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1756598..1756617 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1756601..1756733 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1756622) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1756734..1758221 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1756734..1758221 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1757177..1757194) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1757183) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1757207..1757215) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1758207 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1758269..1758274 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1758290..1758308 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1758295 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1758322..1760220 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1758322..1760220 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1759265..1759284) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1759273) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1759298..1759307) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1760210..1761055 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1760210..1761055 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1761056..1762562 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1761088..1762425) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1761088..1762425) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1761099) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1762453..1762472) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1762468) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1762470..1763628) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1762487..1762494) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1762546..1762549 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1762564..1762583 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1762564 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1762644..1763609 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1762644..1763609 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1763597 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1763659..1764912) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1763659..1764912) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1763673) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1764928..1767762) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1764928..1767762) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1767857..1767876) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1767872) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1767874..1767990) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1767891..1767898) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1767991..1769907) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1767991..1769907) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1769918..1770832) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1769918..1770832) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1770836..1770855) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1770851) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1770872..1770876) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1770896..1771486) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1770896..1771486) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1771579..1772823) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1771579..1772823) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1771581) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1772886..1772904) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1772899) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1772901..1773121) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1772917..1772924) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1773107..1773125) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1773121) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1773137..1773145) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1773205..1774422) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1773205..1774422) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1773231) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1774455..1774474) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1774463) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1774488..1774495) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1774658..1775281) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1774658..1775281) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1775282..1775432) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1775308..1775314 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1775320 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1775328..1775339 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1775346..1775354 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1775362..1775462 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1775366..1775384 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1775377 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1775415..1775433) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1775422..1775507 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1775422 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1775432) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1775449..1775455) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1775483..1775490 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1775503..1775522 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1775509 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1775547..1776905 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1775547..1776905 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1775889..1775900) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1775894) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1775914..1775920) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1776921..1777769 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1776921..1777769 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1777185..1777204) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1777192) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1777218..1777226) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1777732 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1777764) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1777795..1778460) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1777795..1778460) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1777809) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1778479..1778829) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1778479..1778829) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1778826..1779104) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1778826..1779104) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1779131..1779150) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1779147) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1779165..1779171) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1779180..1780076) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1779180..1780076) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1779918..1779927 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1779938 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1779941..1779960 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1779956..1780174 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1780100..1780119) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1780120) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1780131..1780138) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1780175..1780648 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1780175..1780648 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1780645 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1780683..1780919) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1780683..1780919) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1780691) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1780942..1780961) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1780957) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1780975..1780984) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1781004..1782338) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1781004..1782338) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1782339..1782474) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1782471..1782490) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1782481) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1782505..1782512) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1782570..1782577 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1782592..1782611 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1782595 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1782596..1782702 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1782703..1783092 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1782703..1783092 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1783102 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1783499..1783837) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1783499..1783837) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1783860..1783867 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1783881..1783900 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1783890 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1783894..1783966 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1783925..1783944) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1783928) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1783956..1783962) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1783967..1784575 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1783967..1784575 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1784565 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1784618..1785220) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1784618..1785220) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1785236..1786147) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1785236..1786147) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1786176..1786195) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1786192) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1786211..1786216) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1786268..1786271 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1786286..1786305 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1786288 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1786331..1786531 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1786331..1786531 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1786531..1788021 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1786531..1788021 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1787266..1787277) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1787270) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1787291..1787297) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1788009 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1788056..1789456) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1788056..1789456) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1788080) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1789227..1789236 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1789248..1789263 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1789262 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1789476..1789495) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1789496) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1789509..1789516) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1789555..1789564 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1789570 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1789577..1789596 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1789609..1790310 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1789609..1790310 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1790335..1790343 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1790357..1790376 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1790362 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1790398..1790649 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1790398..1790649 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1790670 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1790720..1791541) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1790720..1791541) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1790746) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1791542..1791623) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1791624..1792325) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1791624..1792325) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1792326..1792415) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1792400..1792419) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1792415) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1792435..1792439) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1792473..1792479 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1792494..1792505 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1792511 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1792527..1792652 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1792527..1792652 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1792650 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1792692..1793006) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1792692..1793006) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1792704) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1793027..1793045) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1793034) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1793056..1793064) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1793067..1793678) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1793067..1793678) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1793756..1793932) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1793756..1793932) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1793760) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1793771) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1793775..1793794) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1793810..1793813) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1793946..1793964) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1793967) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1793969..1794190) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1793980..1793985) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1793990..1793995 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1794010..1794028 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1794012 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1794051..1794194 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1794051..1794194 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1794191..1794871) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1794191..1794871) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1794195..1795206 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1794898..1794917) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1794904) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1794931..1794940) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1795022..1795246) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1795022..1795246) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1795036) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1795287..1795306) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1795299) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1795333..1795611) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1795333..1795611) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1795608..1797023) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1795608..1797023) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1796279..1796282 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1796298..1796317 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1796303 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1797052..1797879) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1797052..1797879) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1797857..1799167) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1797857..1799167) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1799176..1799829) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1799176..1799829) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1799814..1800503) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1799814..1800503) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1800510..1801844) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1800510..1801844) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1801825..1801980) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1801825..1801980) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1801863..1801881) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1801879) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1801897..1801902) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1801974..1802207) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1801974..1802207) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1801981) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1802083..1802087 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1802096..1802110 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1802111 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1802112..1802131) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1802121) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1802146..1802155) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1802167..1802946) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1802167..1802946) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1802975..1804255) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1802975..1804255) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1803623..1803641) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1803639) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1803655..1803662) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1804223..1804241) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1804233) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1804257..1804262) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1804320..1804625) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1804320..1804625) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1804453) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1804649..1804668) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1804664) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1804682..1804691) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1804761..1804770 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1804784..1804803 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1804784 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1804805) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1804807..1804821) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1804830..1804834) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1804830..1805231 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1804830..1805231 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1805238..1806191 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1805238..1806191 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1806181 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1806262..1807410) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1806262..1807410) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1806279) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1807423..1807427 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1807436..1807455) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1807443..1807462 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1807445) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1807453 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1807714..1807722 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1807736..1807755 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1807739 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1807780..1808805 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1807780..1808805 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1808183 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1808185..1808189 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1808199..1808200 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1808797 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1808849..1809280) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1808849..1809280) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1808854) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1809281..1809814) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1809281..1809814) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1809818..1809824 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1809835..1809945 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1809835 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1809837..1809856 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1809842..1809861) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1809862) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1809877..1809878) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1809946..1810371 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1809946..1810371 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1810359 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1810404..1811635 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1810421..1811758) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1810421..1811758) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1811830..1812024) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1811830..1812024) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1811843) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1812037..1812600) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1812037..1812600) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1812610..1813377) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1812610..1813377) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1813401..1813420) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1813418) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1813431..1813438) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1813455..1814036) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1813455..1814036) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1814037..1814152) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1814184..1814435) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1814184..1814435) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1814197) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1814458..1814477) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1814472) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1814521..1815789) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1814521..1815789) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1815823..1815842) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1815842) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1815854..1815861) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1815996..1816015 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1815999 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1816038..1817033 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1816038..1817033 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1817054..1817695 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1817054..1817695 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1817696..1818797 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1817734..1818354) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1817734..1818354) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1817760) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1818355..1818861) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1818355..1818861) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(1818858..1819652) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(1818858..1819652) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(1819736..1820269) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(1819736..1820269) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(1819741) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 1820199..1820204 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1820215..1821161 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 1820217 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1820221..1820239 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1820287..1820898) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(1820287..1820898) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(1820930..1820949) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1820949) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1820962..1820967) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1821118 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(1821158..1821931) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(1821158..1821931) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(1821193) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(1821973..1822407) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(1821973..1822407) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(1821985) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1822436..1822455) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(1822447) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(1822449..1822513) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(1822469..1822476) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(1822492) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1822514..1824190) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(1822514..1824190) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(1824191..1824381) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(1824370..1824389) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1824381) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1824404..1824407) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1824479..1825612) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(1824479..1825612) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(1824495) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(1825634..1825653) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1825637) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1825672..1826289) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(1825672..1826289) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(1826305..1826787) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(1826305..1826787) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(1826788..1826935) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(1826926..1826944) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(1826936) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(1826955..1826963) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 1826989..1826998 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1827011..1827026 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 1827013..1827099 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 1827013 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 1827062..1827069 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1827084..1827103 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 1827101 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 1827130..1828035 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 1827130..1828035 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 1828070..1828089 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1828084 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 1828085..1828265 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 1828266..1829414 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 1828266..1829414 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(1828435..1829464) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 1829410 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1829446..1829465) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1829464) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1829480..1829488) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1829495..1829641 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 1829495..1829641 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 1829534..1829541 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1829555..1829574 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1829566..1829656 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 1829566 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1829657..1829857 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 1829657..1829857 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 1829872 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(1829909..1830091) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(1829909..1830091) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 1829917..1830222 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(1829926) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1830152..1830170) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1830184..1830190) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1830188) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1830198..1830204 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1830219..1830230 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1830224 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1830247..1830516 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 1830247..1830516 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 1830371 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 1830499 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1830544..1830726) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(1830544..1830726) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(1830564) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1830719..1831399) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(1830719..1831399) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(1831400..1831537) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 1831416..1831421 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1831434..1831453 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1831439 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1831482..1832171 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 1831482..1832171 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(1831535..1831551) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1831538) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1831539..1831928) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(1831909..1831928) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1831926) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1831940..1831948) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1832171..1832569 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 1832171..1832569 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 1832562..1832568 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1832583..1832594 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1832594 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1832611..1832739 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 1832611..1832739 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 1832740..1833720 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(1832747..1833637) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(1832747..1833637) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(1832784) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1833659..1833678) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1833666) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1833690..1833696) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1833694 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(1833738..1833884) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(1833738..1833884) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(1833754) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1833908) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1833909..1833920) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1833935..1833941) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1833959..1834216) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(1833959..1834216) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(1834236..1834255) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1834251) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1834267..1834274) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1834281..1837862) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(1834281..1837862) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(1837863..1837934) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(1837924..1837943) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1837934) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(1837979..1838176) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(1838022) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1838038..1838127) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(1838038..1838127) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(1838155..1838174) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1838176) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1838189..1838196) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1838198..1838704) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(1838198..1838704) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(1838708..1839805) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(1838708..1839805) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(1839823..1839834) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1839826) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1839849..1839855) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1839879..1841195) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(1839879..1841195) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(1839892) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1841192..1841776) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(1841192..1841776) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(1841865..1841965) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(1841865..1841965) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(1841872) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(1841966..1842106) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(1842107..1843612) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(1842107..1843612) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(1843548..1843648) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1843588) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 1843600 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1843638..1843657) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1843654) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1843671..1843678) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1843724..1844716) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(1843724..1844716) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(1843742) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1844761..1845351) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(1844761..1845351) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(1845353..1846327) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(1845353..1846327) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(1846365..1847384) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(1846365..1847384) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(1847432..1847451) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1847442) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1847463..1847470) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1847505..1847512 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1847526..1847605 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 1847526 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1847527..1847546 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1847606..1848433 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 1847606..1848433 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 1848435..1849199 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 1848435..1849199 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 1849188 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1849230) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1849240..1851165) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(1849240..1851165) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(1851196..1851215) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1851200) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1851202..1851266) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(1851230..1851234) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1851267..1851458) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(1851267..1851458) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(1851477..1851495) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1851486) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1851488..1851793) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(1851511..1851516) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1851525..1851531 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1851546..1851557 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1851555 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 1851622..1851774 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 1851622..1851774 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 1851784 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1851827..1852984) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(1851827..1852984) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(1851838) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1853072..1853472) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(1853072..1853472) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(1853082) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1853469..1853488) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1853487) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1853503..1853509) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1853531..1853827) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(1853531..1853827) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(1853852..1853871) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1853862) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1853885..1853892) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1853905..1854534) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(1853905..1854534) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(1854500) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1854536..1854763) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(1854536..1854763) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(1854791..1854810) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(1854806) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(1854808..1854962) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(1854824..1854832) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(1854847..1854975) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(1854847..1854975) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(1854962) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(1854964..1855075) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(1854965..1854984) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(1855000..1855004) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1855076..1856317) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(1855076..1856317) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(1856031..1856049) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(1856040) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(1856064..1856071) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(1856333..1858582) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(1856333..1858582) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(1858598..1858617) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1858614) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1858631..1858637) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1858685..1859191) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(1858685..1859191) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(1858708) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1859235..1859254) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1859252) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1859268..1859275) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 1859273..1859282 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1859296..1859315 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1859308 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 1859329..1859748 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 1859329..1859748 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 1859749..1859899 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(1859769..1860146) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(1859769..1860146) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(1859802) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 1860144..1860289 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(1860176..1860194) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1860195) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1860208..1860217) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1860290..1860309 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1860291 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1860334..1860522 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 1860334..1860522 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 1860538 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(1860561..1860932) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(1860561..1860932) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(1860594) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1860944..1860963) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1860957) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1860976..1860981) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1860978..1861223) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(1860978..1861223) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(1861249..1861267) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1861254) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1861279..1861287) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1861373..1861379 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1861394..1861405 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1861401 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 1861422..1861526 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 1861422..1861526 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 1861508 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1861551..1862513) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(1861551..1862513) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 1861681..1861690 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1861702..1861717 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1861702 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1861706..1862041 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 1862012..1862016 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1862032..1862051 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1862043..1862553 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 1862043 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1862514..1862970) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 1862554..1863174 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 1862554..1863174 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(1862959..1862970) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1862970) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1862985..1862991) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1863196..1865940 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 1863196..1865940 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(1865610) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 1865926 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1866016..1866510) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(1866016..1866510) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(1866029) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1866507..1867166) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(1866507..1867166) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(1867185..1867883) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(1867185..1867883) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(1867884..1867975) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(1867976..1869268) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(1867976..1869268) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(1869269..1869330) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(1869330..1869349) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1869330) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1869364..1869371) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1869412..1870593) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(1869412..1870593) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(1869416) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1870616..1871101) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(1870616..1871101) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(1871049..1871068) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1871066) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1871081..1871088) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1871110..1871280) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(1871110..1871280) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(1871281..1871352) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 1871314..1871320 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1871335..1871354) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1871335..1871346 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1871342..1871416 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 1871342 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1871352) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1871354..1871422) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(1871370..1871376) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1871386 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1871423..1874218) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(1871423..1874218) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 1871891..1871895 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1871892 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1871897..1871901 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1872548..1872563) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1872562) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1872576..1872585) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(1874219..1874343) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(1874344..1874727) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(1874344..1874727) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(1874729..1875589) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(1874729..1875589) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(1875591..1876424) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(1875591..1876424) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(1876425..1876632) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(1876627..1876646) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1876632) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1876663..1876667) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1876670..1877647) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(1876670..1877647) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(1877632..1878825) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(1877632..1878825) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(1878830..1879963) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(1878830..1879963) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(1879960..1880670) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(1879960..1880670) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(1880663..1881076) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(1880663..1881076) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(1881092..1881895) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(1881092..1881895) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(1881907..1882242) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(1881907..1882242) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(1882262..1882281) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1882272) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1882295..1882302) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 1882311..1882318 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1882327..1882346) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1882332..1882351 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1882338 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1882346) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 1882382..1883254 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 1882382..1883254 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(1883296..1884090) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(1883296..1884090) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(1883321) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(1884091..1884158) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(1884159..1884716) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(1884159..1884716) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(1884717..1884796) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(1884841) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1884863..1885630) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(1884863..1885630) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(1885665..1886339) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(1885665..1886339) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(1886341..1886844) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(1886341..1886844) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 1886853 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1886908..1886927) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1886908) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1886942..1886949) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1886987..1887433) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(1886987..1887433) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 1887436 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(1887488..1888027) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(1887488..1888027) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(1887501) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1888060..1888078) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1888071) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(1888090..1888098) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(1888099..1889370) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(1888099..1889370) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(1889371..1889438) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(1889435..1889454) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1889438) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1889468..1889475) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1889505..1889524) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1889511) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(1889513..1889657) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(1889535..1889542) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(1889639..1889657) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1889657) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1889673..1889678) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1889706..1890992) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(1889706..1890992) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(1889729) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1891003..1892118) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(1891003..1892118) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(1892167..1893249) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(1892167..1893249) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(1893260..1894063) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(1893260..1894063) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(1893748..1893767) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1893765) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1893779..1893786) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1894056..1895258) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(1894056..1895258) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(1895239..1895886) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(1895239..1895886) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(1895333) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(1895509..1895512) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1895509) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(1895729) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 1895891..1896643 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(1895891..1896643) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(1895891..1896643) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(1895924..1895926) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1895927 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(1896033,1896036) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896047,1896049) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896049,1896051) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896074,1896076) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896076,1896080) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896082,1896084) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896091,1896093) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896106,1896108) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896109,1896111) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896114,1896116) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896124,1896126) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896127,1896129) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896130,1896132) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896136,1896138) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896162,1896164) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896194,1896196) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896247,1896249) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896295,1896297) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896310,1896314) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896328,1896330) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896337,1896339) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896349,1896351) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896414,1896416) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896424,1896426) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896432,1896435) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896452,1896454) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896468,1896470) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896496,1896498) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896511,1896513) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896536,1896538) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896553,1896555) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1896568,1896570) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(1896636..1897652) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(1896636..1897652) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(1897624..1899171) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(1897624..1899171) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(1899250..1899381) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(1899293) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1899372..1899391) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(1899381) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(1899387..1899770) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(1899387..1899770) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(1899406..1899413) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(1899767..1900855) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(1899767..1900855) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(1899896..1899911) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1899909) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1899924..1899932) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1900855..1902027) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(1900855..1902027) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(1902062..1902081) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1902079) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1902094..1902101) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1902102..1902872) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(1902102..1902872) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(1902898..1902917) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1902915) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1902929..1902935) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(1902947..1903108) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(1902990) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(1903109..1903558) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(1903109..1903558) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(1903601..1903620) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1903608) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1903633..1903640) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1903674..1904720) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(1903674..1904720) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(1904662..1905363) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(1904662..1905363) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(1905370..1906125) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(1905370..1906125) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(1906126..1906211) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(1906200..1906219) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1906211) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1906230..1906237) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1906289..1906516) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(1906289..1906516) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(1906310) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(1906538..1907110) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(1906538..1907110) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(1907139..1907158) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1907149) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(1907151..1907234) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(1907171..1907177) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(1907279) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(1907298..1907576) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(1907298..1907576) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(1907577..1907802) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(1907784..1907803) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1907802) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1907820..1907825) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1907950..1909428) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(1907950..1909428) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(1907963) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1909429..1909590) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(1909577..1909595) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(1909602) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(1909609..1910343) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(1909609..1910343) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(1909610..1909615) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(1909635) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(1910365..1910568) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(1910365..1910568) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(1910604..1910623) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1910625) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1910637..1910644) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1910690..1910889) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(1910733) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1910864..1910883) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1910889) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1910897..1910906) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1910906..1911943) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(1910906..1911943) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(1911961..1913271) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(1911961..1913271) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(1913272..1913396) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(1913382..1913401) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1913396) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1913416..1913419) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1913425..1913619) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(1913425..1913619) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(1913616..1914509) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(1913616..1914509) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(1914506..1915105) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(1914506..1915105) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 1914978..1914984 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1914993..1915176 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 1914995 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1914998..1915009 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1915116..1915134) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1915135) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1915150..1915155) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1915183..1915314 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 1915183..1915314 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 1915302 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1915357..1916406) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(1915357..1916406) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(1915377) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1916281) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(1916419..1917567) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(1916419..1917567) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 1916748..1916751 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1916775 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1916841 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1917545 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(1917568..1917707) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(1917706..1917725) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1917707) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1917709..1917799) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(1917740..1917747) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1917800..1918474) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(1917800..1918474) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(1918475..1918552) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(1918553..1918729) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(1918553..1918729) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(1918741..1918759) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1918758) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1918774..1918780) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1918774..1919427) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(1918774..1919427) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(1919457..1919476) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1919470) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1919492..1919496) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1919520..1920872) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(1919520..1920872) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(1919535) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1920907..1921824) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(1920907..1921824) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(1921295) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(1921446..1921453) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1921449) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1921862..1921873) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1921871) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1921887..1921893) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1921963..1922619) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(1921963..1922619) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(1921977) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1922644..1922663) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1922659) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1922739..1923713) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(1922739..1923713) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(1922747) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 1923567..1923572 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1923588..1923606 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1923598..1923791 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 1923598 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 1923749 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1923822..1925105) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(1923822..1925105) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(1923825) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 1923863..1923869 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1923881..1923885 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1923881 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1925148..1925167) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1925169) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1925182..1925189) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1925261..1925845) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(1925261..1925845) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(1925263) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(1925846..1925927) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(1925920..1925939) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(1925927) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(1925953..1925960) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(1926004..1926783) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(1926004..1926783) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(1926809..1926824) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(1926820) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(1926836..1926845) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(1926869..1927312) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(1926869..1927312) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(1926886) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1927375..1928097) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(1927375..1928097) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(1927656) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(1928048..1928617) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(1928048..1928617) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(1928366..1928384) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1928382) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1928399..1928405) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1928636..1929382 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(1928677..1930167) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(1928677..1930167) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(1930160..1931218) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(1930160..1931218) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 1930508..1930517 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1930528..1931318 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 1930528 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1930530..1930549 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1931259..1931278) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1931282) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1931290..1931297) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1931296..1931302 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 1931316..1931335 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 1931320..1931389 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 1931320 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 1931369..1931376 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1931391..1931483 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 1931391..1931410 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1931391 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 1931484..1931732 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 1931484..1931732 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 1931716 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1931772..1932344) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(1931772..1932344) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(1931792) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1932336..1932643) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(1932336..1932643) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(1932345..1932449) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(1932642..1932661) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1932658) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1932675..1932681) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1932770..1932777 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1932788 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1932792..1932811 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1932841..1934418 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 1932841..1934418 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 1934400 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(1934461..1935228) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(1934461..1935228) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(1934476) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1934730..1935342 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(1935255..1935274) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1935268) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1935289..1935292) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1935302 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(1935340..1936446) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(1935340..1936446) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(1935357) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(1936382..1936966) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(1936382..1936966) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 1936760..1936765 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1936776 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1936780..1936784 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1936917..1936922 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1936934 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1936938..1936956 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1936974 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1937015..1937034) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1937019..1937126 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(1937023) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1937047..1937054) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1937082 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(1937111..1937169) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(1937142) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1937170..1938939) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(1937170..1938939) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(1937226) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(1938936..1939658) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(1938936..1939658) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(1939659..1939738) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(1939739..1940914) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(1939739..1940914) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(1940934..1942562) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(1940934..1942562) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(1942559..1943098) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(1942559..1943098) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(1943099..1943192) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(1943193..1943927) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(1943193..1943927) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(1943936..1943955) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1943959) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1943970..1943974) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1944019..1944555) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(1944019..1944555) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(1944024..1944043) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1944028) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1944058..1944065) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1944560..1945150) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(1944560..1945150) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(1945138..1946286) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(1945138..1946286) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(1946308..1946326) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1946315) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1946341..1946346) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1946409..1946948) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(1946409..1946948) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(1946422) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1946957..1946974) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1946972) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1946989..1946994) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1947003..1947596) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(1947003..1947596) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(1947586..1948341) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(1947586..1948341) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 1948185..1948194 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1948207..1948226 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1948216 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1948387..1948406) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1948402) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1948420..1948427) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1948567..1948574 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1948585..1948604 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1948590 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 1948622..1949146 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 1948622..1949146 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(1949160..1949534) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(1949160..1949534) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(1949176) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1949596..1949615) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1949608) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1949627..1949634) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1949647..1950111) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(1949647..1950111) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 1949982..1949986 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1950000..1950004 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1950003 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1950144..1951340) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(1950144..1951340) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(1951355..1952002) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(1951355..1952002) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(1952013..1953098) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(1952013..1953098) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(1953099..1953227) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(1953228..1953372) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(1953228..1953372) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(1953389..1953408) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1953399) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1953423..1953430) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1953492..1953836) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(1953492..1953836) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(1953507) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1953868..1953886) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1953881) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1953895..1953900 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1953901..1953907) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1953915..1954837 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 1953915 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1953916..1953934 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1953922..1953937) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1953925) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1953927..1953993) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(1953950..1953959) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1953988..1953996) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1953993) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1954010..1954018) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1954071..1954625) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(1954071..1954625) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(1954081) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1954651..1954670) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1954669) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1954671..1955070) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(1954682..1954688) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1954892..1955128 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 1954892..1955128 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(1955071..1955277) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(1955071..1955277) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(1955310..1955329) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1955332) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(1955386..1955640) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(1955386..1955640) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 1955520..1955529 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1955531..1955920) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(1955531..1955920) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 1955543..1956614 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 1955543..1955562 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1955543 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1955898..1956101) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(1955898..1956101) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 1956510..1956626 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 1956510..1956626 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 1956577 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 1956703..1956712 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1956725..1956744 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1956725 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1956767..1956979 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 1956767..1956979 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 1956973 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(1957115) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1957115..1957546) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(1957115..1957546) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(1957547..1957633) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(1957616..1957635) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1957633) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1957649..1957654) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1957683..1957692 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1957702..1957799 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 1957702 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1957705..1957720 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1957800..1958672 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 1957800..1958672 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 1958579 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1958645 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1958702..1960021) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(1958702..1960021) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(1958722) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1960022..1960086) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(1960082..1960101) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1960086) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1960116..1960123) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1960127..1960745) /gene="spoVAF" /locus_tag="PG10_5'_ext_BSU_23390" /old_locus_tag="BSU_23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /modified_by="User" /translation="MTTSSGKIFRYSCFYFISSDLVSLCASA*SAPGQHEIYRFK*RY AYPDHPADIFS*LRNRVSQNGCHSHTDGFIDSNGFNCRCSDRADCD*GRPFFS*GDSV RLTCGDWNLYDA*L*IKLGKQNEPSCPHDTRCFISYKRARHRIYSANYCHGKHQIPSD TVLMAADSL*RKGAVAGSCPHSETWRKSKTQHRSPQKSLKAAYQFI" /label="PG10_5'_ext_BSU_23390" gene complement(1960127..1960745) /gene="PG10_5'_ext_BSU_23390" /locus_tag="PG10_pseudo_BSU_23390" /old_locus_tag="BSU_23390" /modified_by="User" /label="PG10_5'_ext_BSU_23390" SCAR join(1960731,1960738) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs23" N_region 1960732..1960737 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs23" S_feature complement(<1960738..1960754) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" CDS complement(1960755..1961924) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(1960755..1961924) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(1961953..1961964) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1961968) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1961978..1961984) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1962070) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1962079..1962894) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(1962079..1962894) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(1962907..1964091) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(1962907..1964091) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(1964140..1964159) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1964158) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1964160..1964251) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(1964175..1964182) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1964252..1965142) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(1964252..1965142) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(1965150..1965377) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(1965150..1965377) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(1965280..1965299) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1965291) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1965313..1965320) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1965370) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1965379..1965397) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1965407..1965425) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1965413..1965419) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1965420) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1965442..1965447) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1965502) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(1965502..1965951) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(1965502..1965951) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(1965975..1965994) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(1965985) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(1965987..1966063) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(1966010..1966014) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(1966064..1966708) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(1966064..1966708) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(1966739..1966757) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(1966756) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(1966772..1966777) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(1966809..1967024) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(1966809..1967024) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(1966889) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1967124..1968443) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(1967124..1968443) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(1967131) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(1968461..1969867) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(1968461..1969867) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(1969915..1969934) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1969924) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1969926..1970007) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(1969949..1969956) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1970008..1971435) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(1970008..1971435) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(1971480..1972469) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(1971480..1972469) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(1972470..1972549) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(1972531..1972550) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1972549) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1972551..1972871) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(1972565..1972572) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1972590..1972597 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1972610..1972629 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1972612 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 1972651..1973001 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 1972651..1973001 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(1972873..1973009) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(1972916) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(1973010..1974173) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(1973010..1974173) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(1974170..1974727) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(1974170..1974727) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(1974657..1974757) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1974697) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1974741..1974746 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1974762..1974780 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1974764..1974778) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 1974768 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 1974775..1974949 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(1974780..1974783) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(1974783) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 1974802..1974924 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 1974802..1974924 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 1974925..1974932 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1974946..1974965 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1974951 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 1974987..1975907 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 1974987..1975907 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 1975896 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1975939..1976163) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(1975939..1976163) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(1975996) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1976186..1976205) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1976193) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1976220..1976227) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1976242..1976249 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1976264..1976283 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1976271 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 1976325..1977242 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 1976325..1977242 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 1977217 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(1977282..1977521) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(1977282..1977521) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(1977293) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1977534..1977857) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(1977534..1977857) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(1977600..1977619) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1977601) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1977633..1977640) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1977854..1978885) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(1977854..1978885) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(1977881..1977900) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1977888) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1977911..1977918) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1978878..1979222) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(1978878..1979222) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(1979232..1979702) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(1979232..1979702) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(1979703..1979779) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 1979703 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1979754..1979773) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1979779) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1979781..1979887) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(1979788..1979795) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1979888..1980226) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(1979888..1980226) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(1980223..1981461) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(1980223..1981461) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 1980385..1980386 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1980396 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1980451 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1981486..1981504) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(1981495) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(1981521..1981526) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 1981566..1981569 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1981584..1981603 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1981593 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 1981627..1981833 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 1981627..1981833 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 1982316..1982319 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1982334..1982353 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1982350 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 1982382..1983614 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 1982382..1983614 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 1983461..1983823 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 1983461..1983823 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(1983640..1983819) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(1983673) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1983820..1984206) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(1983820..1984206) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(1984210..1985169) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(1984210..1985169) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(1985170..1985240) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(1985241..1986587) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(1985241..1986587) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(1986588..1986662) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(1986663..1987442) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(1986663..1987442) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(1987448..1988407) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(1987448..1988407) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(1988429..1988448) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1988448) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1988463..1988470) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1988504..1988511 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1988525..1988811 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 1988525 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1988527..1988546 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1988541..1988786 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 1988541..1988786 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 1988812..1989648 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 1988812..1989648 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 1989646 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1989689..1991332) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(1989689..1991332) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(1989701) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1991350..1991356 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1991363 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1991370..1991381 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(1991388..1991407) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1991393) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1991439..1991446 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1991460..1991479 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1991462 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 1991504..1992520 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 1991504..1992520 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 1992507 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 1992569..1992578 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1992591..1992606 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1992595 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 1992630..1993391 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 1992630..1993391 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 1993299 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 1993387 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1993419..1993619) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(1993435..1993560) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(1993435..1993560) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(1993462) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1993553..1993585) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(1993553..1993585) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(1993613..1993632) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1993619) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1993645..1993652) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1993667..1994590) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(1993667..1994590) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(1994616..1994635) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1994629) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1994649..1994654) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1994728..1994735 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1994749..1994768 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1994751..1994816 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 1994751 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 1994817..1996286 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 1994817..1996286 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 1996269 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 1996294..1996333 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(1996306,1996309) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(1996314,1996315) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(1996326,1996327) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 1996335 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1996409..1997818) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(1996409..1997818) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(1996426) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(1996499) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(1997882..1997900) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1997884) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1997928..1999172) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(1997928..1999172) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(1999173..1999447) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 1999193..1999200 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1999214..1999233 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1999214 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 1999245..1999532 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 1999245..1999532 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(1999429..1999448) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(1999449) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(1999464..1999467) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 1999563..2000390 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 1999563..2000390 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 2000207 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2000383 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2000395..2001315) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2000438) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2000508..2000514 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2000528..2000546 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2000537 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 2000570..2001298 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 2000570..2001298 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(2001339..2002454) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(2001339..2002454) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(2001360) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(2002472..2003995) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(2002472..2003995) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(2003578..2003597) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2003600) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2003612..2003616) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2003988..2004410) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(2003988..2004410) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 2004439..2004446 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2004460..2004479 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2004474..2004627 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2004474 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 2004584 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(2004612..2005142) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(2004612..2005142) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 2004629..2005264 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2005159..2005170) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2005166) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2005185..2005191) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2005194..2006162) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(2005194..2006162) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(2005210) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2006233..2006955) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(2006233..2006955) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(2006244) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(2006948..2007607) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(2006948..2007607) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(2007608..2007687) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2007688..2008455) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(2007688..2008455) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(2008505..2008524) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2008520) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2008539..2008546) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2008723..2009160) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(2008723..2009160) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(2008732) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2009184..2009203) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2009205) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(2009218..2009225) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2009258..2009264 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2009277 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2009279..2009297 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2009321..2010214 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 2009321..2010214 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 2010247..2010254 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2010270..2010289 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2010278 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 2010315..2011484 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 2010315..2011484 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 2011467 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 2011557..2012393 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 2011557..2012393 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 2012391 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2012455) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2012455..2013729) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(2012455..2013729) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(2013752..2014735) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(2013752..2014735) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(2014749..2015741) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(2014749..2015741) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(2015763..2017187) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(2015763..2017187) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(2017208..2018299) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(2017208..2018299) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(2018318..2019412) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(2018318..2019412) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(2019424..2020323) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(2019424..2020323) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(2020359..2020378) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2020364) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2020366..2020447) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2020448..2022526) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(2020448..2022526) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(2022586..2022605) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2022603) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2022613..2022620 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2022622..2022625) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2022634..2022653 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2022641 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 2022679..2022915 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 2022679..2022915 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 2022906 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2022957..2023862) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(2022957..2023862) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(2022960) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2023880..2025298) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(2023880..2025298) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(2024175..2024194) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2024192) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2025313..2026431) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(2025313..2026431) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(2026465..2027604) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(2026465..2027604) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(2027632..2028495) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(2027632..2028495) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(2028520..2029701) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(2028520..2029701) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(2029281) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(2029388..2029394) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2029391) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2029615..2029715) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2029655) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2029748..2029766) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2029766) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2029782..2029787) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2029828..2030559) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(2029828..2030559) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(2029835) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2030582..2030601) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2030593) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2030616..2030619) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2030638..2031258) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(2030638..2031258) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(2031273..2031566) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(2031273..2031566) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(2031586..2031605) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2031592) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2031620..2031627) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2031822..2031829 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2031843..2031862 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2031860..2032065 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2031860 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2031874..2032026 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 2031874..2032026 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 2032034..2032041 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2032056..2032075 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2032067 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2032099..2033217 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 2032099..2033217 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 2033202 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2033244..2033414) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2033287) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2033398..2033413) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2033414) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2033416..2033544) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2033425..2033434) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2033543..2033562) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2033566) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2033576..2033584) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2033676) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2033682..2034485) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(2033682..2034485) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(2034528..2034546) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2034534) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2034536..2034688) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2034557..2034565) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2034684..2034703) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2034696) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2034715..2034722) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 2034730..2034731 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_005" CDS complement(2034791..2036521) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(2034791..2036521) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(2034806) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2036558..2037007) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(2036558..2037007) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(2037008..2037093) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2037105..2037950) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(2037105..2037950) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(2037138) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(2037947..2039848) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(2037947..2039848) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 2039056..2039062 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2039077..2039088 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2039085 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2039849..2039977) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2039972..2039991) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2039977) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2040006..2040012) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2040023..2040913) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(2040023..2040913) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(2040903..2041157) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(2040903..2041157) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(2041154..2042500) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(2041154..2042500) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(2042501..2042637) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2042638..2043489) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(2042638..2043489) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(2043501..2043896) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(2043501..2043896) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(2043939..2043958) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2043958) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2043960..2044122) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2044160..2044567) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(2044160..2044567) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(2044167) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(2044588..2045940) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(2044588..2045940) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(2045469..2045488) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2045476) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(2045503..2045509) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2045952..2046431) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(2045952..2046431) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(2046490..2046509) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2046501) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2046523..2046530) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2046587..2047243) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(2046587..2047243) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(2046594) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(2047244..2047933) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(2047244..2047933) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(2047926..2048546) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(2047926..2048546) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(2048252..2048270) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2048270) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2048286..2048291) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2048560..2049759) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(2048560..2049759) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(2049778..2050179) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(2049778..2050179) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(2050186..2050392) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(2050186..2050392) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(2050415..2050930) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(2050415..2050930) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(2050924..2051847) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(2050924..2051847) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(2051848..2051922) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2051923..2052204) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(2051923..2052204) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(2052224..2052242) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2052247) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(2052258..2052263) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2052349..2052906) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(2052349..2052906) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(2052361) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2052931..2053992) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(2052931..2053992) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(2053989..2054435) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(2053989..2054435) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(2054484..2054503) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2054500) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2054516..2054523) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2054522..2055058) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(2054522..2055058) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(2055071..2055082) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2055080) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(2055096..2055102) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2055128..2055134 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2055147 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2055149..2055167 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2055204..2055207 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2055222..2055241 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2055233 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 2055285..2056241 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 2055285..2056241 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 2056281..2056676 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 2056281..2056676 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 2056559..2056659 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2056619 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2056662 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2056673..2057548) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(2056673..2057548) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(2057575..2057593) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2057592) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2057609..2057614) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2057674..2058102) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(2057674..2058102) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(2057701) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2058137..2058156) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2058145) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2058172..2058176) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2058202..2059038) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(2058202..2059038) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(2059062..2059081) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2059073) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2059075..2059619) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2059095..2059102) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2059119..2059124 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2059138..2059157 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2059138 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 2059149..2059228 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2059229..2059609 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 2059229..2059609 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 2059545 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2059589 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2059644..2061110) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(2059644..2061110) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(2059664) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(2061103..2062449) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(2061103..2062449) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(2062479..2063567) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(2062479..2063567) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(2063641..2063840) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(2063641..2063840) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(2063691) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(2063841..2063911) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2063844..2063849 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2063865..2063883 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2063869 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2063879..2064008 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2063897..2063916) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2063911) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(2063930..2063937) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2064009..2065682 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 2064009..2065682 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 2065703..2066497 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 2065703..2066497 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 2066033..2066034 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2066039 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 2066521..2066524 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2066540..2066559 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2066541..2066679 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2066541 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2066680..2066853 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 2066680..2066853 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 2066838..2066842 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2066855..2066874 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2066855 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2066887..2067222 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 2066887..2067222 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 2067199 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 2067289 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts complement(2067321) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2067338,2067345) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27" N_region 2067339..2067344 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs27" promotor_-35 2067414..2067420 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2067421 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2067434..2067445 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2067464..2067790 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 2067464..2067790 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(2067607..2067831) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2067650) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2067772 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2067832..2068011) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(2067832..2068011) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(2068030..2068048) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2068045) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2068063..2068069) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2068082..2068456) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(2068082..2068456) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(2068457..2068840) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(2068457..2068840) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2068866..2069213) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2068866..2069213) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2069197..2069628) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2069197..2069628) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2069618..2069914) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2069618..2069914) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2069928..2070899) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2069928..2070899) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2070952..2072022) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2070952..2072022) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2072040..2072059) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2072056) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2072073..2072080) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2072205..2072433) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2072246) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2072434..2073387) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2072434..2073387) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2073411..2073430) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2073432) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2073444..2073450) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2073470..2073476 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2073491..2073509 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2073509 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2073530..2074858 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2073530..2074858 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2074859..2075833 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2074911..2075747) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2074911..2075747) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2075748..2075932) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2075834..2075904 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2075834..2075904 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2075971..2076351) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2075971..2076351) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2075977) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2076380..2076398) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2076399) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2076413..2076419) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2076438..2076443 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2076459..2076477 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2076468 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2076518..2076525 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2076540 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2076541..2076560 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2076583..2076828 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2076583..2076828 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2076725 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2076814 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2076859..2077614 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2076868..2077503) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2076868..2077503) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2076893) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2077525..2077544) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2077542) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2077558..2077565) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2077582..2077589 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2077604..2077623 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2077616 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2077636) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2077638..2077652) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2077660..2077664) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2077660..2077833 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2077660..2077833 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2077821 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2077865..2078179) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2077865..2078179) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2077866..2078933 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2077879) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2078182..2079243) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2078182..2079243) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2079305..2080435) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2079305..2080435) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2080443..2080461) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2080475) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2080477..2080482) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2080518..2082434) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2080518..2082434) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2080545) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2081550..2081556 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2081569..2082598 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2081569 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2081572..2081590 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2082435..2082501) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2082495..2082514) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2082501) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2082529..2082536) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2082551..2083516) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2082551..2083516) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2083527..2083742) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2083527..2083742) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2083743..2083851) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2083852..2085375) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2083852..2085375) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2085393..2085412) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2085406) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2085427..2085434) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2085465..2085638) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2085465..2085638) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2085492) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2085654..2085665) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2085666) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2085679..2085685) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2085705..2086268) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2085705..2086268) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2086269..2086352) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2086353..2086502) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2086353..2086502) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2086399) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2086539..2086558) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2086549) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2086574..2086577) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2086586..2087665) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2086586..2087665) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2087662..2088132) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2087662..2088132) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2088077..2088085 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2088099..2088107 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2088100..2088273 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2088101 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2088168..2088187) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2088180) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2088199..2088206) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2088245..2088249 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2088265..2088284 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2088275 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2088312..2088665 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2088312..2088665 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2088662..2089126 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2088662..2089126 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2089112 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2089155..2089937) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2089155..2089937) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2089166) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2089948..2090757) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2089948..2090757) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2090778..2091662) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2090778..2091662) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2091662..2092591) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2091662..2092591) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2092660..2093562) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2092660..2093562) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2093617) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2093625..2093641) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2093652..2093654) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2093671,2093673) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2093717..2095867) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2093717..2095867) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2093727) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2094461..2094479) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2094469) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2094495..2094501) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2095156..2095175) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2095173) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2095189..2095198) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2095917..2095936) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2095922) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2095952..2095956) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2095981..2097273) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2095981..2097273) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2097296..2097307) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2097307) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2097321..2097327) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2097380..2097988) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2097380..2097988) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2097395) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2098040..2098059) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2098051) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2098053..2098121) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2098074..2098081) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2098112..2098130) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2098121) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2098145..2098151) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2098167..2098649) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2098167..2098649) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2098650..2098942) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2098692..2098698 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2098713..2098732 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2098726 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2098759..2099526 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2098759..2099526 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2098940..2098958) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2098942) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2098944..2099880) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2098972..2098978) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2099527..2099957 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2099914 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2099925) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2099942..2100370) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2099942..2100370) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2100366..2100370 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2100380..2100394 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2100389 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2100393..2100412) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2100416) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2100427..2100434) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2100585..2100590 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2100606..2100624 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2100618 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2100647..2100946 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2100647..2100946 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2100959..2100966 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2100981..2101000 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2100992..2101068 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2100992 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2101069..2102202 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2101069..2102202 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2102183 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2102228..2102617) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2102228..2102617) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2102254) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2102648..2102659) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2102652) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2102673..2102679) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2102692..2102699 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2102710..2102729 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2102711 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2102750..2103331 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2102750..2103331 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2103329 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2103374..2103982 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2103374..2103811) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2103374..2103811) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2103378) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2103812..2103906) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2103902..2103921) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2103906) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2103936..2103943) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2103949..2104830) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2103949..2104830) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2104826..2104831 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2104847..2104865 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2104863 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2104868..2104887) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2104874) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2104876..2105203) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2104892..2104901 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2104908 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2104914..2104933 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2104946..2105200 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2104946..2105200 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2105187 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2105227..2106120) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2105227..2106120) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2105232..2106033 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2105248) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2106130..2107446) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2106130..2107446) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2107482..2107501) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2107493) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2107517..2107521) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2107550..2107559 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2107571 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2107573..2107592 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2107615..2108358 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2107615..2108358 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2108340 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2108362..2108369 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2108383..2108402 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2108385..2108480 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2108385 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2108481..2109425 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2108481..2109425 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2109396 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2109448..2110569) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2109448..2110569) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2109473) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2110562..2111212) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2110562..2111212) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2111213..2111321) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2111309..2111328) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2111321) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2111323..2111436) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2111344..2111348) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2111469..2111831) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2111469..2111831) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2111481) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2111827..2111831 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2111839..2111853 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2111860 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2111868..2111887) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2111870) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2111872..2111993) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2111899..2111906) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2111982..2112001) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2111990..2112009 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2111993) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2111995..2112134) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2111996..2112100 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2111996 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2112015..2112021) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2112064..2112071 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2112085..2112104 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2112102..2114251 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2112102 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2112160..2113275) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2112160..2113275) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2112179) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2113276..2113473) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2113474..2115285) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2113474..2115285) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2114880..2114886 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2114896 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2114898..2114917 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2114925..2115221 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2114925..2115221 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2115319..2115813) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2115319..2115813) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2115786..2115804) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2115797) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2115814..2115927) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2115816..2115824) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2115822..2115827 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2115843..2115861 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2115858 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2115912..2115930) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2115927) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2115929..2116006) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2115946..2115951) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2115972..2115991) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2116006) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2116007..2116010) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2116067..2116879) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2116067..2116879) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2116905..2117543) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2116905..2117543) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2117544..2117675) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2117669..2117688) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2117676..2119715) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2117676..2119715) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2117678) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2117703..2117710) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2117722) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2117788) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2119708..2120595) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2119708..2120595) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2120678..2120852) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2120678..2120852) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2120712) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2120827..2120832 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2120848..2120866 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2120856..2120875) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2120858..2122270 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2120858 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2120868) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2120890..2120897) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2120892..2121659) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2120892..2121659) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2121696..2121839) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2121696..2121839) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2121840..2121986) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2121987..2122892) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2121987..2122892) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2122873..2123283) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2122873..2123283) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2123321..2123340) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2123332) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2123334..2123401) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2123355..2123358) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2123402..2123773) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2123402..2123773) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2123754..2124227) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2123754..2124227) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2124228..2126363) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2124228..2126363) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2126207..2126212 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2126227 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2126228..2126246 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2126442..2127401) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2126442..2127401) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2126457) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2127398..2128594) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2127398..2128594) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2127465..2127484) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2127470) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2127498..2127505) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2127545..2127563) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2127557) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2127578..2127584) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2127772) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2127786..2127797) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2127812..2127818) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2128613..2128894) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2128613..2128894) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2128951..2129370) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2128951..2129370) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2128965) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2129395..2130390) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2129395..2130390) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2130412..2131725) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2130412..2131725) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2131761..2131776) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2131778) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2131789..2131798) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2131856..2132302) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2131856..2132302) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2131869) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2132067) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2132317..2132490) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2132317..2132490) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2132426..2132430 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2132431 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2132551..2132570) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2132566) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2132584..2132591) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2132609..2132614 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2132629 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2132630..2132648 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2132663..2133586 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2132663..2133586 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2133623..2134978) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2133623..2134978) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2133629) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2134978..2135748) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2134978..2135748) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2135771..2136706) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2135771..2136706) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2136731..2137858) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2136731..2137858) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2137775..2137778 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2137786 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2137859..2138036) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2137898..2137988 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2137898..2137988 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2138058..2139893) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2138058..2139893) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2138081) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2139917..2140480) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2139917..2140480) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2140481..2140551) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2140552..2141583) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2140552..2141583) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2141624..2141643) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2141637) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2141658..2141665) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2141664..2142803) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2141664..2142803) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2142676..2142687) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2142680) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2142701..2142707) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2142856..2144694) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2142856..2144694) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2142878) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2144729..2144748) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2144746) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2144764..2144768) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2144828..2145166) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2144828..2145166) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2144834) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2145183..2146388) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2145183..2146388) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2146408..2146426) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2146420) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2146442..2146447) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2146451..2147557) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2146451..2147557) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2147585..2147596) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2147592) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2147611..2147617) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2147656..2147659 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2147672 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2147675..2147694 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2147686..2147760 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2147761..2148027 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2147761..2148027 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2148016 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2148042..2149085) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2148042..2149085) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2148087) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2149114..2149133) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2149125..2149274) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2149125..2149274) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2149126) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2149147..2149151) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2149149..2149488) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2149192) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2149261..2149267 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2149281..2149300 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2149282 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2149315..2149449 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2149315..2149449 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2149443 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2149489..2151819) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2149489..2151819) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2149506..2149525) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2149522) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2149539..2149548) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2151823..2152392) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2151823..2152392) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2152419..2152438) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2152429) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2152453..2152460) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2152459..2153076) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2152459..2153076) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2153097..2153102 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2153114 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2153118..2153136 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2153137..2153151) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2153139) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2153141..2153988) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2153160..2153164) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2153160..2153981 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2153160..2153981 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2153976..2153995) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2153982..2154062 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2153989) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2154009..2154016) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2154022 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2154047..2154790) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2154047..2154790) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2154077) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2154787..2155143) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2154787..2155143) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2155161..2155721) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2155161..2155721) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2155711..2156280) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2155711..2156280) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2156292..2156582) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2156292..2156582) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2156576..2157418) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2156576..2157418) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2157410 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2157436..2158536) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2157436..2158536) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2158540..2159058) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2158540..2159058) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2158968..2158985) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2158982) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2159001..2159004) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2159059..2159620) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2159092) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2159283..2159290 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2159301..2159401 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2159301..2159320 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2159301 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2159351..2159609) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2159351..2159609) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2159402..2159560 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2159402..2159560 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2159561..2159807 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2159608..2159627) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2159619) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2159643..2159647) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2159671..2159818) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2159708) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2159764 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2159809..>2159886 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2159813..2159832) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2159818) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2159845..2159854) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2159886,2159888) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" N_region 2159887 /note="inserted C residue" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" S_feature <2159888..2160330 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" CDS complement(2159901..2160317) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2159901..2160317) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2160363..2161661) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2160363..2161661) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2161648..2162343) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2161648..2162343) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2162409..2162426) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2162418) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2162504..2162510 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2162517..2162535 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2162532 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2162611..2163828 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2162611..2163828 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2163070..2163077 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2163092..2163111 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2163108 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2163747..2163995 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2163747..2163995 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2163924..2164971) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2164340..2164897 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2164340..2164897 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2164898..2165020 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2164973..2165387) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2165016) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2165388..2165912) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2165388..2165912) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2165760..2165767 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2165778..2165797 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2165792 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2165913..2166000) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2165995..2166014) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2166000) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2166002..>2166138) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2166029..2166036) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2166138,2166145) /created_by="User" /note="deletion occured in betwen marked nucleotides " /modified_by="User" /label="IIG_Bs12" N_region 2166139..2166144 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs12" CDS complement(2166197..2166727) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2166197..2166727) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2166773..2166792) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2166796) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2166806..2166813) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2166862..2167842 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2166862..2167842 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2168116..2169432) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2168116..2169432) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2169433..2169546) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2169547..2170416) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2169547..2170416) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2170439..2170458) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170456) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2170473..2170478) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2170523..2170524) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170531) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2170561..2170562) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2170561..2171664 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2170561..2171664 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2171554..2171573 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2171560 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2171911) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2171937..2172770) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2171937..2172770) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2172800..2172819) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2172809) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2172975..2172979 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2172990..2173212 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2172990 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2172994..2173013 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2173213..2173476 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2173213..2173476 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2173464 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2173613..2174428 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2173613..2174428 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2174763..2174835) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2174806) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2174836..2175192) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2174836..2175192) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2175245..2175604) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2175245..2175604) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2175697..2175716) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2175707) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2175876..2175977) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2175876..2175977) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2176017..2176119) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2176059) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2176120..2176506) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2176120..2176506) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2176548..2176564) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2176564) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2176697..2176703 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2176718..2176729 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2176718 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2176755..2177000 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2176755..2177000 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2177018..2177386 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2177018..2177386 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2177405..2178541 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2177405..2178541 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2178560..2178757 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2178560..2178757 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2178773..2179072 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2178773..2179072 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2179063 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2179335..2179757) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2179335..2179757) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2179755..2179758 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2179774..2179793 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2179789..2179939 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2179789 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2179792..2179811) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2179799) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2179825..2179832) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2179908..2179927) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2179916) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2179940..2180134 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2179940..2180134 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2179942..2179949) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2180152..2180159 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2180175..2180194 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2180179 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2180180..2180264 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2180265..2181314 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2180265..2181314 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2181382..2181389 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2181404..2181423 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2181417 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2181445..2181954 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2181445..2181954 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2181923 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2181968..2183073 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2181996..2184029) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2181996..2184029) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2182021) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2183938..2184105) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2183938..2184105) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2184030..2184185) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2184186..2185013) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2184186..2185013) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2185034..2185843) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2185034..2185843) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2185860..2186348) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2185860..2186348) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2186348..2186788) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2186348..2186788) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2186785 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2186825..2186843) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2186829) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2186978..2189785) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2186978..2189785) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2190001..2190020) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2190007) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2190332..2190472 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2190332..2190472 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2190453..2190472 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2190463 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2190511..2191899 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2190511..2191899 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2191888 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2191921..2191994) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2191963) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2191995..2192627) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2191995..2192627) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2192051) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2192681..2192700) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2192692) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2192706..2192712 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2192715..2192722) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2192726..2192745 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2192731 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2192780..2193607 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2192780..2193607 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2193603 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2193720..2193729 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2193742..2193757 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2193747 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2193803..2194303 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2193803..2194303 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2194303..2195160 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2194303..2195160 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2195178..2195189) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2195197) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2195204..2195210) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2195271..2197175 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2195271..2197175 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2197256..2197262 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2197278..2197296 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2197284 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2197309..2197599 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2197309..2197599 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2197600..2197715 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2197697..2197704 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2197717..2197842 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2197717 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2197718..2197736 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2197736..2197836 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2197736..2197836 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2197799 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2197843..2201007) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2197843..2201007) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2197859) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2198993..2199002 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2199016..2199035 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2199037 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2201023..2201607) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2201023..2201607) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2201830..2202372) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2201830..2202372) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2202373..2202458) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2202456..2202471) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2202458) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2202484..2202493) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2202527..2202743) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2202561..2202719) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2202561..2202719) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2202570) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2202741..2202760) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2202743) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2202745..2202875) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2202774..2202783) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2202876..2203025) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2202876..2203025) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2203019 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2203026..2203116) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2203118..2203337) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2203161) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2203283 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2203316..2203335) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2203337) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2203339..2203414) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2203350..2203357) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2203415..2204215) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2203415..2204215) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2204284..2204437) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2204327) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2204428..2204447) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2204437) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2204462..2204468) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2204478..2204846) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2204478..2204846) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2204847..2204943) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2204929..2204948) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2204933..2204936 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2204949) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2204952..2204971 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2204954 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2204955..2205161 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2204964..2204968) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2205162..2208104 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2205162..2208104 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2208123..2208605 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2208123..2208605 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2208585 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2208641..2208871) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2208641..2208871) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2208661) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2208872..2208953) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2208954..2210093) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2208954..2210093) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2210095..2211018) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2210095..2211018) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2211011) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2211019..2211082) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2211083..2211778) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2211083..2211778) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2211518..2211537) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2211536) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2211550..2211559) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2211799..2212440) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2211799..2212440) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2212007..2212026) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2212026) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2212043..2212046) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2212492..2212501 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2212498..2212517) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2212504) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2212514..2212533 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2212523..2212587 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2212523 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2212533..2212536) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2212568..2212575 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2212589 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2212591..2212608 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2212633..2212836 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2212633..2212836 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2212843 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2212873..2213574) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2212873..2213574) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2212885) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2213639..2215393) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2213639..2215393) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2213667..2213686) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2213677) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2214708..2214723) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2214711) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2214736..2214745) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2214939..2214957) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2214953) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2214972..2214979 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2214972..2214977) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2214994..2215013 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2214999 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2215447..2215920) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2215447..2215920) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2215454) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2215921..2216053) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2216035..2216054) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2216053) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2216055..2216163) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2216068..2216075) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2216156..2216175) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2216163) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2216171..2216806) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2216171..2216806) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2216191..2216195) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2216301..2216306 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2216322..2216340 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2216329 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2216813..2218081) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2216813..2218081) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2218100..2219029) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2218100..2219029) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2219035..2219688) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2219035..2219688) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2219689..2219793) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2219775..2219794) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2219793) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2219810..2219814) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2219840..2220922) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2219840..2220922) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2219874) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2220938..2220957) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220958) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2220972..2220975) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2221048) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2221053..2221334) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2221053..2221334) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2221113) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2221352..2221768) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2221352..2221768) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2221600..2221618) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2221619) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2221634..2221639) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2221776..2222042) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2221776..2222042) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2221930..2221938 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2221953..2221972 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2221961..2223150 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2221961 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2222043..2222103) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2222097..2222116) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2222103) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2222127..2224763) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2222127..2224763) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2222130..2222137) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2224529..2224547) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2224545) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2224561..2224568) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2224764..2224842) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2224843..2225050) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2224843..2225050) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2225058..2225077) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2225073) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2225092..2225099) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2225094..2226155) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2225094..2226155) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2226064..2226069 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2226075..2226310 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2226076 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2226085..2226103 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2226172..2226183) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2226173) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2226197..2226203) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2226311..2227039 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2226311..2227039 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2226767) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2227061..2227882 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2227061..2227882 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2227943..2228593 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2227943..2228593 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2228610..2229266 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2228610..2229266 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2229265 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2229301..2229432) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2229301..2229432) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2229319) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2229454..2229645) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2229454..2229645) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2229657..2230181) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2229657..2230181) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2229768) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2229772..2229783) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2229798..2229804) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2230152..2230163) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2230158) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2230178..2230184) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2230239..2232635) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2230239..2232635) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2230265) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2230485..2230491 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2230499 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2230506..2230517 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2230519..2230868 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2230620) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2232660..2233280) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2232660..2233280) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2233366..2234481) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2233366..2234481) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2233367) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2234512..2235651) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2234512..2235651) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2235218..2235237) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2235230) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2235251..2235258) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2235670..2236086) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2235670..2236086) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2236087..2236184) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2236169..2236188) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2236184) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2236204..2236207) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2236232..2236239 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2236253..2236272 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2236261 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2236289..2237554 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2236289..2237554 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2237553 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2237596..2238360) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2237596..2238360) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2237614) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2238444..2238644) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2238444..2238644) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2238462) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2238631 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2238632..2238641 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2238642..2238661) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2238653) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2238674..2238681) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2238696..2240474) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2238696..2240474) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2240488..2241762) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2240488..2241762) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2241852..2242084) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2241852..2242084) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2241882) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2242094..2242097 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2242108..2242127) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2242112..2242131 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2242114..2242398 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2242114 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2242127) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2242142..2242149) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2242144..2242314) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2242144..2242314) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2242345..2242356) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2242362) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2242371..2242377) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2242374..2242381 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2242395..2242413 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2242400 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2242447..2244003 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2242447..2244003 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2243982 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2244030..2244428) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2244030..2244428) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2244038) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2244482..2246686) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2244482..2246686) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2246715..2246734) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2246722) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2246724..2246814) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2246749..2246756) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2246778 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2246854..2247366) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2246854..2247366) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2246859) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2247372..2249732) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2247372..2249732) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2247836..2247855) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2247844) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2247869..2247878) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2249746..2249765) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2249757) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2249780..2249786) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2249799..2250122) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2249799..2250122) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2250143..2250161) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2250154) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2250176..2250182) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2250198..2250695) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2250198..2250695) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2250696..2250771) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2250765..2250784) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2250771) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2250798..2250805) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2250853..2253066) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2250853..2253066) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2250858) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2252625..2252630 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2252644..2252663 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2252652 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2253105..2253401) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2253105..2253401) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2253312 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2253402..2253480) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2253442..2253447 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2253464..2253482 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2253466..2253485) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2253466 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2253480) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2253482..2254400) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2253500..2253503) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2253517..2255073 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2253517..2255073 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2254386..2254404) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2254400) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2254416..2254424) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2255074..2255838 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2255077..2255733) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2255077..2255733) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2255752..2255763) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2255764) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2255777..2255783) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2255816..2255821 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2255837..2255855 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2255840 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2255868..2256320 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2255868..2256320 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2256304 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2256359) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2256377..2256643) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2256377..2256643) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2256680..2257825) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2256680..2257825) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2256732) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2256776) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2256778..2256797) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2256812..2256817) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2257852..2258880) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2257852..2258880) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2258910..2259110) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2258910..2259110) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2259103..2260107) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2259103..2260107) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2260118..2260723) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2260118..2260723) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2260742..2260761) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2260758) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2260760..2260861) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2260772..2260778) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2260862..2261374) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2260862..2261374) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2261403..2261414) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2261418) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2261422..2262729) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2261422..2262729) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2261429..2261435) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2262683) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2262753..2262771) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2262768) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2262786..2262792) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2262800..2263825) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2262800..2263825) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2263862..2263881) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2263882) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2263896..2263903) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2263951..2263958 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2263972..2263991 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2263980 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2264012..2264017 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2264026 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2264033..2264051 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2264063..2264710 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2264063..2264710 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2264385..2264718) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2264689 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2264720..2264917) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2264756..2264878) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2264756..2264878) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2264763) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2264926) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2264927..2264944) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2264951..2264958) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2264963..2265253 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2264963..2265253 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2264974..2264993 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2264974..2265121 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2264974 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2265260..2265400 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2265260..2265400 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2265389 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2265449..2265455 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2265463..2265563 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2265470..2265488 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2265471 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2265523 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2265564..2267018 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2265564..2267018 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2267019 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2267059..2267781) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2267059..2267781) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2267064..2267485 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2267075) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2267804..2267823) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2267821) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2267837..2267844) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2267884..2268480) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2267884..2268480) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2267899) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2268523..2268534) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2268525) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2268527..2268591) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2268549..2268555) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2268628..2269791) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2268628..2269791) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2268636) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2269792..2269867) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2269843..2269861) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2269867) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2269877..2269882) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2269908..2271014) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2269908..2271014) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2270590..2270608) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2270615) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2270624..2270629) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2270926 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2270927..2270930 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2271001..2271870) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2271001..2271870) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2271095 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2271824..2273419) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2271824..2273419) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2273447..2273454 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2273447..2273466) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2273468 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2273470..2273489 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2273471) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2273481..2273488) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2273522..2274709 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2273522..2274709 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2273523..2273542) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2273541) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2273557..2273566) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2274424..2274429 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2274438 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2274440..2274459 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2274669..2275211 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2274669..2275211 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2275194 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2275236..2276093) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2275236..2276093) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2275239..2275948 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2275256) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2276110..2276553) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2276110..2276553) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2276614..2277900) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2276614..2277900) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2277934..2278512) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2277934..2278512) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2278513..2278578) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2278563..2278582) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2278578) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2278580..2278797) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2278590..2278712 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2278590..2278712 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2278596..2278603) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2278833..2279117) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2278833..2279117) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2278842) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2279130..2279468) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2279130..2279468) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2279471..2279779) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2279471..2279779) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2279793..2279868) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2279793..2279868) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2279880..2279899) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2279900) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2279913..2279920) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2279926..2280792) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2279926..2280792) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2280785..2281579) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2280785..2281579) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2281582 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2281588..2281688 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2281603..2281621) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2281614) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2281637..2281642) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2281648 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2281691 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2281726) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2281729..2282535) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2281729..2282535) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2282537..2283217) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2282537..2283217) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2283270..2283788) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2283270..2283788) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2283785..2284657) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2283785..2284657) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2284688..2285701) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2284688..2285701) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2285742) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2285754..2285772) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2285793..2286488) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2285793..2286488) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2286525..2287094) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2286525..2287094) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2286946..2286961) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2286955) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2286974..2286983) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2287133..2287152) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2287149) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2287166..2287172) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2287245) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2287247..2288245) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2287247..2288245) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2288292..2288311) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2288300) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2288323..2288330) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2288368) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2288379..2289125) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2288379..2289125) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2289153..2289172) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2289160) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2289187..2289194) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2289265..2290557) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2289265..2290557) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2289270) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2290558..2290616) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2290617..2293259) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2290617..2293259) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2293260..2293318) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2293319..2293541) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2293319..2293541) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2293362) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2293570..2293589) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2293582) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2293584..2293692) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2293604..2293609) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2293646..2293655 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2293668..2293687 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2293669 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2293685..2293699) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2293692) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2293707..2293711) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2293707..2293898 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2293707..2293898 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2293917..2294942) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2293917..2294942) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2293947) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2294975..2296702) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2294975..2296702) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2296304..2296307 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2296323..2296342 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2296329 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2296698..2296702 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2296711..2296725 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2296725 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2296740..2296758) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2296756) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2296774..2296779) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2296833..2298125) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2296833..2298125) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2296850) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2298155..2299129) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2298155..2299129) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2299126..2299914) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2299126..2299914) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2299904..2300848) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2299904..2300848) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2300881..2301711) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2300881..2301711) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2301719..2303086) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2301719..2303086) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2303150..2303169) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2303156) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2303158..2303247) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2303207..2303226 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2303215 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2303244..2303263) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2303247) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2303249..2303665) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2303274..2303282) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2303316..2303813 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2303316..2303813 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2303649..2303667) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2303665) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2303667..2303797) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2303683..2303689) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2303777..2303788) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2303797) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2303803..2303809) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2303835..2304422) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2303835..2304422) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2303863) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2304419..2306743) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2304419..2306743) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2306744..2306855) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2306840..2306859) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2306855) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2306873..2306880) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2306924..2308582) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2306924..2308582) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2306943) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2308626..2308644) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2308637) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2308660..2308665) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2308734..2309996) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2308734..2309996) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2308744) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2309997..2310086) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2310074..2310093) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2310086) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2310088..2310219) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2310105..2310112) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2310264) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2310268..2311542) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2310268..2311542) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2311543..2311732) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2311719..2311738) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2311732) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2311753..2311757) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2311770..2312774) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2311770..2312774) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2312799..2312818) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2312817) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2312830..2312837) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2312893..2313492) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2312893..2313492) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2312914) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2313505..2314923) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2313505..2314923) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2314812..2314816 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2314831..2314835 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2314831 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2314973..2316070) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2314973..2316070) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2316091..2317647) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2316091..2317647) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2316487..2316490 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2316503..2318944 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2316503 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2316505..2316524 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2317634..2318662) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2317634..2318662) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2318686..2319204) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2318686..2319204) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2318925..2318928 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2318944..2318948 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2318946 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2319201..2320925) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2319201..2320925) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2320926..2321046) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2321047..2321293) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2321047..2321293) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2321090) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2321294..2321420) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2321402..2321421) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2321420) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2321422..2321552) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2321436..2321443) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2321547..2321566) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2321556) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2321580..2321583) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2321678..2321687 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2321701..2321720 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2321703 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2321741..2322076 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2321741..2322076 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2322070 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2322157..2322164 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2322178..2322197 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2322180..2322244 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2322180 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2322245..2322700 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2322245..2322700 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2322808..2322814 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2322828..2322846 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2322835 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2322884..2323705 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2322884..2323705 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2323698 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2323762 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2323769..2323842) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2323769..2323842) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2323803) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2323879..2323898) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2323882) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2323912..2323919) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2323973..2324482) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2323973..2324482) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2323990) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2324498..2325094) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2324498..2325094) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2325107..2325844) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2325107..2325844) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2325926..2325945) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2325942) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2325955..2327055) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2325955..2327055) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2325960..2325965) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2325972) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2327078..2327096) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2327094) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2327111..2327116) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2327170..2327988) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2327170..2327988) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2327182) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2327996..2328436) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2327996..2328436) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2328479..2328498) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2328488) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2328490..2328632) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2328514..2328518) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2328677) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2328680..2328904) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2328680..2328904) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2328953 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2328955..2328973 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2328962..2328981) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2328982) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2328995..2329004) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2329020..2329463) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2329020..2329463) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2329524..2330285) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2329524..2330285) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2329532) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2330288..2332048) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2330288..2332048) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2332082..2332690) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2332082..2332690) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2332460..2332467 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2332480..2332499 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2332482 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2332691..2332786) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2332776..2332795) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2332786) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2332788..2333409) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2332810..2332817) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2332925..2332929 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2332939..2333039 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2332946..2332965 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2332955 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2332983..2333429 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2332983..2333429 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2332999 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2333417 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2333455) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2333473..2334699) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2333473..2333964) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2333473..2334699) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2333473..2333964) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2334813) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2334825..2335004) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2334825..2335004) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2334857) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2335029..2335048) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2335036) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2335061..2335068) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2335069..2336841) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2335069..2336841) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2336868..2336887) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2336882) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2336901..2336908) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2336971) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2336977..2337291) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2336977..2337291) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2337317..2337336) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2337331) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2337333..2337542) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2337352..2337354) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2337436..2337546) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2337436..2337546) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2337532..2337550) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2337542) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2337565..2337571) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2337614..2339101) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2337614..2339101) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2339102..2339214) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2339195..2339214) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2339214) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2339229..2339236) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2339318..2340295) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2339318..2340295) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2339326) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2340331..2341104) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2340331..2341104) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2341119..2341895) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2341119..2341895) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2341184 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2341910..2342494) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2341910..2342494) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2342536..2342555) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2342536) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2342568..2342575) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2342599..2344281) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2342599..2344281) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2344310..2344329) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2344318) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2344406) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2344470..2344874) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2344470..2344874) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2344472) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2344889..2347246) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2344889..2347246) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2347267..2348979) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2347267..2348979) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2348980..2349052) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2349053..2349586) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2349053..2349586) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2349593..2349850) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2349593..2349850) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2349877..2349896) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2349893) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2349908..2349915) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2349933..2349952 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2349940 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2349984..2350925 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2349984..2350925 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2350657..2350676) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2350672) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2350690..2350697) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2350908 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2350940) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2350961..2353375) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2350961..2353375) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2350984) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2353391..2354425) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2353391..2354425) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2354426..2354746) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2354507..2354713 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2354507..2354713 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2354736..2355000 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2354736 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2354741..2354760) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2354743..2354757 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2354746) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2354775..2354778) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2354780..2355526) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2354780..2355526) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2355553..2355572) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2355559..2355565 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2355566) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2355579..2355590 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2355586..2355592) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2355593 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2355645..2355860 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2355645..2355860 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2355842..2357254) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2355871..2355878 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2355894..2355913 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2355902 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2355929..2357035 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2355929..2357035 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2357071..2357074 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2357090..2357109 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2357094 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2357138..2358550 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2357138..2358550 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2357240..2357259) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2357254) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2357272..2357281) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2358547..2359881 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2358547..2359881 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2359580,2359582) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2359879 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2359918) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2359920..2360162) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2359920..2360162) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2360163..2360334) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2360222..2360392) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2360222..2360392) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2360335..2362131) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2360335..2362131) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2360437..2360455) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2360455) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2360467..2360475) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2362128 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2362156..2362175) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2362166) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2362190..2362196) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2362226..2362282) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2362250) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2362283..2363785) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2362283..2363785) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2363656) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2363760..2363860) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2363800) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2363804..2364649) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2363804..2364649) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2364650..2365591) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2364650..2365591) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2365627..2366928) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2365627..2366928) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2366959..2368143) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2366959..2368143) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2368140..2368958) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2368140..2368958) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2368936..2369625) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2368936..2369625) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2369642..2371324) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2369642..2371324) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2371338..2372828) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2371338..2372828) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2372921..2372940) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2372928) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2372930..2373005) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2372955..2372962) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2373006..2373977) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2373006..2373977) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2373978..2374106) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2374091..2374110) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2374106) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2374125..2374128) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2374174..2375259) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2374174..2375259) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2374188) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2375285..2375304) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2375308) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2375319..2375326) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2375377..2375386 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2375392 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2375398..2375413 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2375443..2375835 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2375443..2375835 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2375806 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2375851..2376157 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2375851..2376120) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2375851..2376120) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2375867) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2376036) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2376114 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2376177..2376536) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2376177..2376536) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2376190) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2376568..2376768) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2376568..2376768) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2376781..2377302) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2376781..2377302) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2377364..2377503) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2377364..2377503) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2377500..2377519) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2377510) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2377512..2377576) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2377533..2377540) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2377558..2377577) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2377576) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2377593..2377597) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2377695..2377702 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2377716..2377734 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2377716 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2377748..2378413 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2377748..2378413 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2378391 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2378445..2379140) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2378445..2379140) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2378467) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2378511) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2379162..2379602) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2379162..2379602) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2379624..2379643) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2379643) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2379659..2379662) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2379736..2380461) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2379736..2380461) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2379765) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2380439..2382220) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2380439..2382220) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2382304..2382307 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2382316..2382335) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2382321) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2382322..2382341 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2382329 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2382387..2383169 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2382387..2383169 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2383153 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2383203) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2383210..2385141) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2383210..2385141) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2385185..2385432) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2385185..2385432) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2385188..2385197) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2385188) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2385243) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2385443..2385462) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2385456) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2385458..2385538) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2385478..2385482) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2385539..2386384) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2385539..2386384) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2386404..2386422) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2386410) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2386438..2386443) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2386463..2387104) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2386463..2387104) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2387138..2388073) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2387138..2388073) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2388101..2389519) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2388101..2389519) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2389548..2389567) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2389556) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2389582..2389585) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2389634..2390092) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2389634..2390092) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2389653) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2390093..2390240) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2390231..2390250) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2390240) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2390242..2390320) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2390265..2390268) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2390365) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2390366..2390746) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2390366..2390746) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2390747..2390901) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2390881..2390900) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2390888 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2390889..2390908 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2390901) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2390915..2390921) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2390979..2390990) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2390985..2392007) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2390985..2392007) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2390986) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2391005..2391011) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2392051..2392070) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2392082) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2392083..2392090) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2392213..2392593) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2392213..2392593) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2392237) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2392594..2392724) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2392649..2392653 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2392669..2392688 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2392670..2392776 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2392670 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2392714..2392733) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2392724) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2392748..2392755) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2392777..2393967 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2392777..2393967 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2393599..2393617) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2393615) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2393633..2393638) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2393991..2394833 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2393991..2394833 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2394606..2394611 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2394627..2394645 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2394628 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2394826 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2394866) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2394875..2395468) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2394875..2395468) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2395484..2396116) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2395484..2396116) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2396117..2396281) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2396282..2397112) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2396282..2397112) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2397135..2399777) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2397135..2399777) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2399832..2399851) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2399841) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2399865..2399872) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2399901..2400020) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2399944) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2400021..2401760) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2400021..2401760) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2401753..2402475) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2401753..2402475) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2402543..2402562) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2402553) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2402555..2402655) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2402576..2402582) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2402687..2403625) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2402687..2403625) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2402700) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2403669..2404940) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2403669..2404940) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2404725..2404744) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2404737) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2404941..2405023) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2405023) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2405025..2405103) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2405025..2405044) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2405060..2405064) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2405104..2406222) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2405104..2406222) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2405717 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2406064..2406067 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2406072 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2406201 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2406223..2406429) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2406397..2406409 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2406408 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2406415..2406434) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2406429) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2406449..2406453) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2406549) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2406556..2407020) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2406556..2407020) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2407033..2407052) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2407047) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2407049..2408234) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2407049..2407054 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2407065..2407073) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2407069..2407087 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2407075 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2407117..2408232 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2407117..2408232 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2408203 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2408265..2408648) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2408265..2408648) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2408279) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2408649..2408740) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2408741..2410498) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2408741..2410498) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2410541..2411500) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2410541..2411500) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2411501..2411602) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2411591..2411610) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2411602) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2411626..2411630) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2411684..2412661) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2411684..2412661) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2411711) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2412646..2413518) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2412646..2413518) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2413480..2413485 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2413501..2413519 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2413505..2414679 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2413505 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2413519..2413602) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2413591..2413610) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2413602) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2413604..2413756) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2413626..2413630) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2413758..2413852) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2413801) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2413853..2415085) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2413853..2415085) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2415086..2415202) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2415190..2415209) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2415202) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2415222..2418569) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2415222..2418569) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2415223..2415230) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2416234..2416243 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2416255..2416270 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2416255 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2416443..2416462) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2416462) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2416476..2416483) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2418600..2418619) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2418618) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2418633..2418640) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2418658..2418663 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2418675 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2418679..2418697 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2418709..2419050 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2418709..2419050 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2419047..2419550 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2419047..2419550 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2419583..2419586 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2419601..2419620 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2419601 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2419652..2419843 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2419652..2419843 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2419653) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2419819 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2419861..2420802) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2419861..2420802) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2419864..2420235 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2419896) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2420204..2420213 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2420227..2420246 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2420237..2420631 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2420237 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2420593..2420599 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2420615..2420634 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2420633..2420932 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2420633 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2420821..2420840) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2420837) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2420839..2421253) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2420855..2420858) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2420933..2421235 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2420933..2421235 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2421236..2423031 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2421254..2422573) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2421254..2422573) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2422599..2422618) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2422620) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2422633..2422638) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2422749..2423651) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2422749..2423651) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2423670..2424920) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2423670..2424920) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2424938..2425630) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2424938..2425630) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2425677..2427005) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2425677..2427005) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2427002..2427283) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2427002..2427283) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2427298..2428302) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2427298..2428302) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2428299..2429078) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2428299..2429078) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2429075..2429782) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2429075..2429782) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2429812..2430531) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2429812..2430531) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2430357..2430364 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2430379..2430398 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2430379 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2430553..2431365) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2430553..2431365) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2431379..2432188) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2431379..2432188) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2432202..2432738) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2432202..2432738) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2432775..2432782 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2432793..2432812) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2432796..2432815 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2432799..2432890 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2432799 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2432809) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2432826..2432833) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2432891..2433817 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2432891..2433817 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2433293..2433822) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2433867) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2433868..2434551) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2433868..2434551) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2434552..2434613) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2434614..2435381) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2434614..2435381) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2435426..2435445) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2435448) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2435461..2435463) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2435508..2435744) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2435508..2435744) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2435593 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2435613) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2435704..2437089) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2435704..2437089) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2437086..2438297) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2437086..2438297) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2438298..2438375) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2438368..2438387) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2438374) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2438402..2438409) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2438467..2438979) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2438467..2438979) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2438485) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2439005..2439024) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2439013) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2439038..2439045) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2439064..2440251) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2439064..2440251) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2439079) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2440252..2440356) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2440341..2440360) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2440356) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2440358..2440487) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2440376..2440380) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2440424..2440627) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2440424..2440627) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2440485..2440496) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2440487) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2440511..2440517) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2440599..2441588) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2440599..2441588) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2440617) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2441649..2442152) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2441649..2442152) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2441655) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2441869..2441969 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2441929 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2442148 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2442175..2442194) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2442191) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2442208..2442215) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2442262..2442717) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2442262..2442717) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2442290) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2442731..2443411) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2442731..2443411) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2442823) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2442830..2442841) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2442856..2442862) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2443149) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2443424..2443442) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2443438) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2443457..2443462) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2443486..2443980) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2443486..2443980) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2443501) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2443993..2445000) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2443993..2445000) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2445024..2445039) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2445041) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2445043..2445122) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2445051..2445060) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2445100..2445119 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2445110 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2445115..2445134) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2445119..2445185 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2445122) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2445150..2445154) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2445186..2445989 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2445186..2445989 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2445919 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2445977 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2446021..2447610) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2446021..2447610) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2446030) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2447630..2449219) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2447630..2449219) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2449265..2449282) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2449270) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2449298..2449304) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2449397) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2449398..2449607) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2449398..2449607) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2449603..2449607 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2449607 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2449616..2449630 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2449628..2449639) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2449639) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2449654..2449660) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2449701..2450906) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2449701..2450906) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2450910..2452055) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2450910..2452055) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2452056..2453199) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2452142..2452149 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2452160..2452249 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2452160 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2452162..2452181 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2452250..2453587 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2452250..2453587 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2453185..2453204) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2453199) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2453219..2453226) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2453563 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2453682..2455370) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2453682..2455370) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2453683) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2455371..2455476) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2455453..2455461 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2455464..2455483) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2455472..2455491 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2455476) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2455476 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2455477..2455566 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2455478..2456037) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2455499..2455501) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2455567..2456373 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2455567..2456373 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2456041..2456060) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2456054) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2456072..2456079) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2456323..2456369) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2456345) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2456370..2456993) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2456370..2456993) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2456374..2456716 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2456694..2456701 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2456716..2456735 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2456718..2456861 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2456718 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2456833..2456837 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2456853..2456872 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2456863..2456993 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2456863 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2456995..2457119 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2456995 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2457009..2457027) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2457011..2457030 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2457027) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2457038..2457046) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2457120..2457611 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2457120..2457611 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2457590 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2457649..2459388) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2457649..2459388) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2457667) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2458862..2458869 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2458883..2458901 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2458886 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2458888..2459483 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2459418..2459437) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2459426) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2459428..2460261) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2459464..2459471 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2459485..2459682 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2459485..2459504 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2459485 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2459542..2459674 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2459542..2459674 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2459683..2460285 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2459683..2460285 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2460208 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2460263..2460482) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2460271 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2460306) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2460318 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2460363..2460536 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2460478..2460496) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2460490) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2460494 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2460511..2460517) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2460556..2461824) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2460556..2461824) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2460582) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2461848..2462121) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2461848..2462121) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2461869..2462012) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2461912) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2462119..2462138) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2462131) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2462151..2462158) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2462166..2463884) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2462166..2463884) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2463898..2463905 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2463912..2463931) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2463920..2463939 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2463926 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2463935) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2463945..2463951) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2463968..2463975 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2463989..2464008 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2463992 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2464045..2464677 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2464045..2464677 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2464250..2464258 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2464272..2464291 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2464278 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2464704..2465348 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2464704..2465348 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2465345..2466508 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2465345..2466508 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2466499 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2466519..2467247) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2466519..2467247) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2466555) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2467237..2468055) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2467237..2468055) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2468118..2469122) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2468118..2469122) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2468135) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2469157..2469176) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2469172) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2469174..2469282) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2469282..2469301) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2469282) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2469284..2469349) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2469315..2469321) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2469395) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2469398..2470474) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2469398..2470474) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2470515..2470534) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2470535) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2470537..2470637) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2470549..2470556) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2470571 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2470625..2470644) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2470637) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2470658..2470664) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2470710..2471036) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2470710..2471036) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2470719) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2471060..2471515) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2471060..2471515) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2471546..2471968) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2471546..2471968) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2471989..2472007) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2472002) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2472021..2472027) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2472041..2472059) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2472050) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2472070..2472078) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2472130..2473428) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2472130..2473428) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2472139) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2473453..2473472) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2473454) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2473456..2473652) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2473485..2473494) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2473635..2473654) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2473652) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2473666..2473672) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2473678..2476536) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2473678..2476536) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2476570..2476589) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2476580) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2476605..2476609) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2476679) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2476696..2477301) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2476696..2477301) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2477317..2478126) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2477317..2478126) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2478141..2478464) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2478141..2478464) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2478465..2478603) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2478503..2478619) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2478503..2478619) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2478590..2478609) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2478603) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2478611..2478618 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2478633..2478652 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2478638 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2478699..2479145 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2478699..2479145 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2479146..2479874 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2479200..2480273) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2479200..2480273) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2479219) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2480295..2480314) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2480299) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2480328..2480335) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2480370..2480373 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2480388..2480407 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2480393 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2480432..2480749 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2480432..2480749 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2480749 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2480802..2482502) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2480802..2482502) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2480821) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2482534..2482552) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2482541) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2482567..2482573) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2482584..2483354) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2482584..2483354) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2483355..2483443) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2483441..2483460) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2483443) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2483476..2483480) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2483500..2484141) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2483500..2484141) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2483510) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2483575) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2484167..2484186) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2484176) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2484178..2484626) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2484202..2484206) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2484285..2484291 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2484306..2484317 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2484313 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2484348..2484626 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2484348..2484626 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2484627..2484797 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2484627..2485241) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2484627..2485241) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2484775 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2485242..2485577) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2485569..2485588) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2485577) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2485603..2485610) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2485604..2487760) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2485604..2487760) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2487301,2487303) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2487786..2488715) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2487786..2488715) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2488764..2489678) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2488764..2489678) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2489441..2489459) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2489449) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2489473..2489479) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2489704..2490255) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2489704..2490255) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2490118..2490137 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2490121 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2490278..2490297) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2490290) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2490313..2490316) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2490338..2490345 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2490356..2490375 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2490359..2490370) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2490363 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2490373) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2490384..2490390) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2490404..2491339 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2490404..2491339 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2491315 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2491373..2492764) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2491373..2492764) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2491385) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2492765..2493205) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2492791..2492796 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2492810..2492829 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2492823 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2492861..2494159 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2492861..2494159 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2493182..2493201) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2493205) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2493216..2493222) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2494146 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2494199..2495356) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2494199..2495356) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2494224) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2494472..2494477 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2494492..2494510 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2494500 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2495353..2496063) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2495353..2496063) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2496077..2496092) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2496094) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2496104..2496113) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2496120..2496121 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2496133..2496238 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2496133 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2496141..2496151 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2496204..2496210 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2496225..2496244 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2496240..2496353 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2496240 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2496354..2496575 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2496354..2496575 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2496558 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2496627 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2496696..2497415) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2496696..2497415) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2496710) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2497481) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2497484..2499118) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2497484..2499118) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2499150..2499169) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2499166) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2499236..2499240 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2499256..2499275 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2499274 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2499320..2500582 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2499320..2500582 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2500583..2500681 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2500655..2500661 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2500677..2500695 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2500683..2500770 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2500683 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2500771..2502309 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2500771..2502309 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2502289 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2502346..2502528) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2502346..2502528) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2502365) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2502543..2502561) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2502563) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2502577..2502582) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2502596..2503264) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2502596..2503264) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2503286..2504572) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2503286..2504572) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2504584..2505087) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2504584..2505087) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2505084..2506205) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2505084..2506205) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2506213..2507178) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2506213..2507178) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2507204) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2507205..2507224) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2507239..2507246) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2507334..2507341 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2507354 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2507357..2507376 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2507394..2509712 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2507394..2509712 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2509702 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2509753..2511249) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2509753..2511249) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2509755) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2511274..2512134) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2511274..2512134) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2512210..2512229) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2512219) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2512245..2512252) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2512341..2513102) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2512341..2513102) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2512370) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2513103..2513178) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2513179..2514366) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2513179..2514366) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2514435..2515442) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2514435..2515442) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2515445..2516140) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2515445..2516140) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2516137..2517306) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2516137..2517306) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2516173..2516180 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2516195..2516214 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2516213 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2517296..2518642) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2517296..2518642) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2517712..2517716 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2517731 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2517732..2517750 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2518632..2519408) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2518632..2519408) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2519409..2519501) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2519487..2519506) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2519501) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2519521..2519528) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2519618..2520517) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2519618..2520517) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2520540..2520558) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2520557) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2520569..2520577) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2520647..2520654 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2520670..2520689 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2520676 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2520735..2521769 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2520735..2521769 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2521718..2521725 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2521740..2521748 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2521757 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2521803..2523083 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2521803..2523083 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2523076..2523987 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2523076..2523987 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2523984..2524814 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2523984..2524814 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2524787..2524791 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2524807..2524826 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2524815 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2524834..2526132 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2524834..2526132 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2526113 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2526154..2526465) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2526154..2526465) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2526165) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2526489..2526508) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2526497) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2526523..2526530) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2526531 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2526582..2528996) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2526582..2528996) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2526586) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2528997..2529092) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2529106..2529320) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2529106..2529320) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2529137) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2529332..2529351) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2529353) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2529357..2529362 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2529366..2529371) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2529378..2529396 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2529391..2529831 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2529391 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2529423..2529758) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2529423..2529758) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2529753..2530017) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2530002..2530021) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2530017) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2530036..2530043) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2530056..2530063 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2530077..2530096 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2530093 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2530095..2530162 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2530163..2530948 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2530163..2530948 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2530949..2531005 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2531185..2532378) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2531185..2532378) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2531205) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2532379..2532477) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2532458..2532477) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2532477) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2532491..2532498) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2532515..2532518 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2532533..2532552 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2532537 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2532567..2533313 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2532567..2533313 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2533208 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2533307 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2533350..2535290) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2533350..2535290) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2533361) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2535280..2536041) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2535280..2536041) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2536065..2536083) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2536084) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2536143..2537147) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2536143..2537147) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2536182) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2537140..2537835) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2537140..2537835) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2537859..2537877) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2537871) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2537893..2537896) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2537932..2539242) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2537932..2539242) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2537954) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2539232..2539927) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2539232..2539927) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2539942..2540919) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2539942..2540919) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2540949..2541935) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2540949..2541935) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2541805..2541814 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2541821 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2541827..2541842 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2541929..2542807) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2541929..2542807) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2542800..2543192) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2542800..2543192) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2543193..2543437) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2543226..2543363) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2543226..2543363) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2543361 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2543432..2543451) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2543437) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2543465..2543472) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2543518..2543790) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2543518..2543790) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2543525) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2543830..2543841) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2543834..2543842 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2543834) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2543845 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2543856..2543862) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2543856..2543874 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2543885..2543890 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2543904..2543923 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2543911 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2543952..2544920 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2543952..2544920 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2544917..2545501 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2544917..2545501 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2545465 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2545491..>2545622) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /modified_by="User" /translation="LAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC* " /label="IIG_Bs13_pseudo_BSU_30500" gene complement(2545491..>2545622) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /modified_by="User" /label="IIG_Bs13_pseudo_BSU_30500" downshifts complement(2545532) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR 2545625..2545626 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs13" S_feature complement(<2545626..2545641) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" promotor_-10 complement(2545632..2545651) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2545641) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2545643..2545777) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2545663..2545670) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2545752..2545771) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2545777) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2545870..2547261) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2545870..2547261) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2545878) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2547262..2547396) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2547397..2549295) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2547397..2549295) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2548453..2548459 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2548474..2548485 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2548486 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2549296..2549419) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2549445..2550647) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2549445..2550647) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2549464) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2550690..2550701) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2550696) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2550698..2550814) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2550715..2550721) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2550815..2550953) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2550815..2550953) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2550913 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2550962..2550981) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2550977) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2550998..2551002) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2551074..2551081 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2551093 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2551095..2551114 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2551150..2552733 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2551150..2552733 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2552722 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2552772..2553014) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2552772..2553014) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2552786) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2553066..2553839) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2553066..2553839) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2553840..2553930) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2553906..2553915 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2553919..2553938) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2553927 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2553928..2553947 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2553932) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2553953..2553960) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2553990..2554994 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2553990..2554994 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2555007..2555789 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2555007..2555789 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2555011..2556559) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2555764..2556576 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2555764..2556576 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2556561 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2556603..2557079) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2556603..2557079) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2556604) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2557109..2557128) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2557122) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2557124..2557258) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2557258) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2557260..2557271) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2557286..2557292) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2557288..2557692) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2557288..2557692) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2557720..2557739) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2557737) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2557739..2557825) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2557752..2557761) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2557858..2558295) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2557858..2558295) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2557870) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2558312..2558330) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2558330) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2558332..2558557) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2558345..2558351) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2558387..2558406 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2558388..2558564 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2558388..2558564 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2558389 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2558558..2558995) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2558558..2558995) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2558584 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2559014..2559033) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2559035) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2559044..2559052) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2559115..2559588) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2559115..2559588) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2559124) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2559211) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2559589..2559940) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2559660..2559667 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2559680..2559699 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2559685 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2559717..2559944 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2559717..2559944 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2559941..2560504) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2559941..2560504) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2560529..2560548) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2560544) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2560598..2560846) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2560598..2560846) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2560619) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2560874..2560893) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2560907..2560914) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2560911) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2560973..2560979 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2560993..2561004 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2561005 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2561051..2562382 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2561051..2562382 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2562426..2563466 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2562426..2563466 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2563460..2563466 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2563481..2563492 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2563491 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2563520..2563678 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2563520..2563678 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2563667 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2563697..2564584) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2563697..2564584) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2563720) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2564574..2565881) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2564574..2565881) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2565887..2566639) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2565887..2566639) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2566658..2567578) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2566658..2567578) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2567614..2567625) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2567615) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2567617..2567708) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2567639..2567645) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2567693 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2567694..2567713) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2567696..2567708 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2567708) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2567710..2567791) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2567728..2567735) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2567791) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2567800..2567819) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2567833..2567840) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2567858..2568973) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2567858..2568973) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2567901) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2568970..2570430) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2568970..2570430) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2569873..2569891) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2569877) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2569906..2569912) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2570519) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2570521..2571336) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2570521..2571336) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2571371..2572195) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2571371..2572195) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2571453..2571472) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2571453) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2571488..2571491) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2571619) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2571629..2571640) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2571655..2571661) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2572183..2573925) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2572183..2573925) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2573922..2575337) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2573922..2575337) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2575338..2575450) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2575430..2575449) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2575450) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2575452..2575602) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2575465..2575468) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2575563..2575569 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2575583..2575602) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2575583..2575594 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2575591 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2575602) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2575616..2575625) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2575627..2576346 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2575627..2576346 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2575697..2576354) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2576335 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2576355..2577173) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2576355..2577173) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2577194..2577213) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2577208) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2577228..2577236) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2577274..2577282 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2577295..2577314 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2577296 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2577345..2578631 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2577345..2578631 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2578628..2579578 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2578628..2579578 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2579581..2580804 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2579581..2580804 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2580728) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2580805..2581372 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2580878..2581309) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2580878..2581309) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2580904) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2581311..2582366) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2581311..2582366) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2582381..2583514) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2582381..2583514) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2583547..2583566) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2583566) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2583579..2583588) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2583652..2583661 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2583675..2583694 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2583677 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2583704..2584777 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2583704..2584777 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2584001..2584007 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2584018 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2584021..2584032 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2584766 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2584804..2584810 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2584825 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2584826..2584844 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2584857..2585324 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2584857..2585324 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2585296 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2585355..2587751) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2585355..2587751) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2585370) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2587738..2589192) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2587738..2589192) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2589189..2590220) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2589189..2590220) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2590244..2591386) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2590244..2591386) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2591383..2593266) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2591383..2593266) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2592092..2593511 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2593298..2593313) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2593311) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2593328..2593333) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2593378) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2593499..2593570) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2593499..2593570) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2593596..2593686) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2593596..2593686) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2593690..2593764) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2593690..2593764) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2593775..2593851) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2593775..2593851) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2593867..2593940) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2593867..2593940) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2593951..2594026) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2593951..2594026) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2594044..2594119) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2594044..2594119) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2594132..2594208) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2594132..2594208) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2594220..2594296) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2594220..2594296) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2594314..2594406) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2594314..2594406) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2594413..2594489) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2594413..2594489) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2594492..2594568) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2594492..2594568) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2594588..2594660) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2594588..2594660) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2594666..2594742) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2594666..2594742) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2594758..2594834) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2594758..2594834) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2594844..2594929) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2594844..2594929) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2594944..2595018) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2594944..2595018) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2595024..2595110) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2595024..2595110) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2595121..2595196) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2595121..2595196) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2595234..2595309) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2595234..2595309) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2595342..2595417) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2595342..2595417) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2595438..2595555) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2595438..2595555) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2595611..2598538) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2595611..2598538) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2598706..2600260) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2598706..2600260) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2600062,2600064) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2600261..2600552) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2600388..2600396 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2600394 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2600504 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2600525..2600544) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2600552) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2600554..2601520) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2600558..2600565) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2600677..2600680 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2600692 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2600695..2600714 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2600725..2600826 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2600725..2600826 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2600825 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2600926..2601504 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2600926..2601504 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2601494 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2601546..2602067) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2601546..2602067) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2601564) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2601636) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2602085..2603614) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2602085..2603614) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2603635..2604159) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2603635..2604159) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2604203..2604218) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2604209) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2604211..2604298) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2604230..2604239) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2604283..2604301) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2604293 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2604297..2604316 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2604298) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2604316..2604321) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2604327..2604815 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2604327..2604815 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2604792 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2604821..2605399) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2604821..2605399) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2604837..2605228 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2604848) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2605433..2605452) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2605442) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2605466..2605473) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2605487..2606695) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2605487..2606695) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2605508) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2606464..2606483) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2606476) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2606498..2606505) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2606712..2608184) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2606712..2608184) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2608235..2608254) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2608236) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2608269..2608276) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2608296..2608302 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2608316..2608335 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2608331 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2608383..2608925 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2608383..2608925 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2608908 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2609002..2609009 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2609022..2609122 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2609022 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2609024..2609043 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2609123..2609668 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2609123..2609668 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2609655 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2609760..2609767 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2609781..2609800 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2609788 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2609793..2609961 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2609793..2609961 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2609942 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2610034..2610702 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2610034..2610702 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2610709..2612046 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2610709..2612046 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2612032 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2612082..2612345) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2612082..2612345) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2612100) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2612385..2612404) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2612387) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2612417..2612424) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2612454..2613302) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2612454..2613302) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2613347..2613366) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2613357) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2613381..2613388) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2613463..2614998) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2613463..2614998) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2613472) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2614656..2614756 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2614716 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2614782 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2614999..2615166) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2615155..2615174) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2615166) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2615168..2616045) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2615189..2615196) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2615408..2615417 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2615431..2615450 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2615431 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2615483..2615968 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2615483..2615968 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2615969..2616255 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2616075..2616147) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2616075..2616147) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2616090) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2616134) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2616158..2616177) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2616178) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2616192..2616195) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2616212 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2616255..2617085) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2616255..2617085) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2616266) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2617086..2617177) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2617178..2618344) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2617178..2618344) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2618340..2618344 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2618352..2618366 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2618368..2618387) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2618368 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2618387) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2618401..2618408) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2618466..2618473 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2618479 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2618484..2618503 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2618526..2619512 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" /label="iolU CDS" gene 2618526..2619512 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /label="iolU gene" downshifts 2619483 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2619553..2620827) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" /label="rhaA CDS" gene complement(2619553..2620827) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /label="rhaA gene" downshifts complement(2619566) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2620853..2621167) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" /label="rhaM CDS" gene complement(2620853..2621167) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /label="rhaM gene" CDS complement(2621185..2622642) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" /label="rhaB CDS" gene complement(2621185..2622642) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /label="rhaB gene" CDS complement(2622647..2623423) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" /label="rhaR CDS" gene complement(2622647..2623423) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /label="rhaR gene" misc_feature complement(2623457..2623476) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2623473) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2623480..2625549) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" /label="rhaE CDS" gene complement(2623480..2625549) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /label="rhaE gene" promotor_-10 complement(2625582..2625601) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2625594) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2625615..2625621) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2625687..2627675) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" /label="tlpB CDS" gene complement(2625687..2627675) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /label="tlpB gene" downshifts complement(2625706) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2627679..2627686 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2627696..2627714) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2627702..2627721 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2627709) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="upshifts" upshifts 2627718 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2627728..2627735) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2627784 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2627789..2629774) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" /label="mcpA CDS" gene complement(2627789..2629774) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /label="mcpA gene" downshifts complement(2627794) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2629795..2629813) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2629810) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2629812..2629899) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2629827..2629834) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2629900..2631888) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" /label="tlpA CDS" gene complement(2629900..2631888) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /label="tlpA gene" promotor_-10 complement(2631913..2631931) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2631928) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="upshifts" promotor_-35 complement(2631945..2631952) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2632065..2634053) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" /label="mcpB CDS" gene complement(2632065..2634053) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /label="mcpB gene" downshifts complement(2632084) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2634074..2634092) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2634095) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2634105..2634112) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2634155..2634164 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2634178..2634197 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2634181 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="upshifts" CDS 2634211..2634948 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" /label="tgl CDS" gene 2634211..2634948 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /label="tgl gene" promotor_-10 complement(2634236..2634255) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2634244) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="upshifts" promotor_-35 complement(2634271..2634275) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2634949..2637769 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2634962..2635216) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" /label="yuzH CDS" gene complement(2634962..2635216) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /label="yuzH gene" downshifts complement(2634988) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2635217..2635473) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2635474..2635872) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" /label="yugU CDS" gene complement(2635474..2635872) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /label="yugU gene" CDS complement(2635832..2635966) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" /label="hypothetical protein CDS" gene complement(2635832..2635966) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /label="gene" promotor_-10 complement(2635915..2635934) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2635922) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2635949..2635955) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2635992..2637656) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" /label="yugT CDS" gene complement(2635992..2637656) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /label="yugT gene" downshifts complement(2636008) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2636964..2636983) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2636969) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2636997..2637004) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2637681..2637699) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2637698) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2637715..2637720) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2637783..2639072) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" /label="yugS CDS" gene complement(2637783..2639072) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /label="yugS gene" downshifts complement(2637792) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" /label="downshifts" promotor_-35 2638601..2638607 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2638621..2638639 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2638627 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="upshifts" S_feature 2638631..2639283 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2639116..2639793) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" /label="yugP CDS" gene complement(2639116..2639793) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /label="yugP gene" downshifts complement(2639126) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" S_feature 2639468..2640144 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2639828..2639847) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2639835..2640098) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" /label="yuzI CDS" gene complement(2639835..2640098) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /label="yuzI gene" upshifts complement(2639849) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2639861..2639868) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2640110..2640128) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2640124) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2640144..2640149) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2640145..2640477 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" /label="mstX CDS" gene 2640145..2640477 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /label="mstX gene" promotor_-35 2640162..2640168 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2640183..2640200 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2640194 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="upshifts" CDS 2640474..2641460 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" /label="kbfO CDS" gene 2640474..2641460 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /label="kbfO gene" downshifts complement(2641435) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2641457..2641861) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" /label="yugN CDS" gene complement(2641457..2641861) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /label="yugN gene" S_feature complement(2641862..2641920) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2641921..2642292) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" /label="yugM CDS" gene complement(2641921..2642292) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /label="yugM gene" CDS complement(2642351..2643703) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2642351..2643703) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2642362) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2642518..2642536) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2642535) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2642552..2642557) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2643676) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2643679..2643690) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2643735..2643754) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2643741) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2643743..2643814) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2643769..2643772) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2643815..2644987) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2643815..2644987) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2644150..2645071 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2645020..2645039) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2645033) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2645056..2645059) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2645091..2646254) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2645091..2646254) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2645106) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2646269..2646288) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2646287) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2646289..2646444) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2646303..2646310) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2646340..2646346 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2646361..2646379 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2646371 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2646372..2646430 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2646417..2646423 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2646419..2646430) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2646432 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2646437..2646448 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2646444..2646450) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2646444) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2646446..2646757) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2646484..2646720 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2646484..2646720 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2646680 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2646746 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2646798..2647190) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2646798..2647190) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2646802) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2647232..2647251) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2647239) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2647241..2647391) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2647267..2647271) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2647294..2647300 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2647307..2648291 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2647307 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2647315..2647333 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2647392..2648552) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2647392..2648552) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2648444..2648450 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2648462 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2648464..2648468 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2648553..2649053) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2648553..2649053) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2649083..2649102) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2649089..2649095 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2649104) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2649110..2649121 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2649110 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2649113..2649120) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2649122..2649200 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2649201..2650022 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2649201..2650022 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2650002 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2650049) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2650051..2650311) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2650051..2650311) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2650301..2650304 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2650319..2650338 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2650331 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2650332..2650397 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2650337..2650356) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2650342) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2650368..2650374) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2650398..2651561 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2650398..2651561 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2651624..2651630 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2651642..2651661 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2651652 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2651687..2652973 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2651687..2652973 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2652689..2653431) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2652968..2652975 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2652989..2653008 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2652990 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2653019..2653405 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2653019..2653405 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2653387 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2653432..2654049) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2653432..2654049) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2654084..2654102) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2654101) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2654103..2656191) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2654117..2654122) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2654165..2654168 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2654183..2654202 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2654194 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2654260..2655438 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2654260..2655438 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2655476..2655482 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2655494..2655513 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2655499 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2655531..2657405 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2655531..2657405 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2656171..2656190) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2656191) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2656204..2656213) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2657426..2657839 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2657426..2657839 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2657831 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2658042..2658599) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2658042..2658599) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2658063..2658082 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2658073 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2658083) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2658095..2658776 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2658625..2658644) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2658633) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2658660..2658664) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2658777..2660378 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2658777..2660378 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2660371..2661078 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2660371..2661078 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2661063 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2661242..2661249 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2661260..2661549 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2661260 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2661264..2661283 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2661550..2662629 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2661550..2662629 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2662705..2664237 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2662705..2664237 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2664230..2665276 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2664230..2665276 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2665277..2666236 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2665277..2666236 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2666237..2666358 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2666331..2666334 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2666349..2666368 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2666360 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2666390..2667736 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2666390..2667736 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2667719 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2667772..2667987) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2667772..2667987) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2667927..2667933 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2667947..2667958 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2667951 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2667998..2668016) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2668005) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2668030..2668037 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2668032..2668037) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2668052..2668147 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2668052..2668071 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2668052 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2668110..2668114 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2668130..2668149 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2668149..2668298 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2668149 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2668218..2670623 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2668218..2670623 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2670616..2671047 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2670616..2671047 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2671047..2671388 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2671047..2671388 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2671279..2671379 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2671339 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2671381..2672862 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2671381..2672862 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2672114..2673982) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2672868..2673344 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2672868..2673344 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2673344..2673628 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2673344..2673628 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2673612..2673986 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2673612..2673986 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2673957 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2674025..2674405) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2674025..2674405) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2674027) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2674424..2675068) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2674424..2675068) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2675069..2675148) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2675149..2677458) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2675149..2677458) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2676143..2676150 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2676164..2676183 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2676179 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2677052..2678023 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2677052 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2677064..2677080 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2677473..2677640) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2677473..2677640) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2677628..2678526) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2677628..2678526) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2678527..2678640) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2678634..2678653) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2678640) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2678667..2678673) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2678711..2678851) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2678711..2678851) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2678740) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2678852..2678938) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2678922..2678941) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2678938) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2678955..2678961) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2679038..2679056) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2679048) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2679071..2679077) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2679073..2679198 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2679073..2679198 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2679226..2679655) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2679251..2679256 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2679268) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2679271..2679289 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2679273 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2679312..2679680 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2679312..2679680 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2679656..2680885) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2679656..2680885) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2679681..2680994 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2680920..2680939) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2680939) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2680952 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2680954..2680961) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2681022..2682494) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2681022..2682494) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2681032) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2682375..2682379 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2682382 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2682492 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2682510..2683061) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2682510..2683061) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2683083..2683102) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2683096) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2683115..2683122) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2683158..2683556) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2683158..2683556) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2683557..2683627) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2683628..2683876) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2683628..2683876) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2683899..2683918) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2683910) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2683934..2683937) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2683949..2684170) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2683949..2684170) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2683976) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2684164 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2684188..2684207) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2684194) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2684220..2684229) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2684230..2685339) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2684230..2685339) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2684991..2684998 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2685013..2685032 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2685022..2685416 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2685022 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2685387..2685406) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2685403) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2685405..2685845) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2685408..2685410 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2685418 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2685420..2685425) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2685426..2685445 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2685454..2685843 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2685454..2685843 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2685884..2686120) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2685884..2686120) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2685890) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2686140..2686159) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2686154) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2686156..2686296) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2686173..2686182) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2686297..2686827) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2686297..2686827) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2686847..2686866) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2686858) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2686860..2686946) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2686878..2686886) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2686941..2686960) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2686948) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2686974..2686983) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2687025..2687756) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2687025..2687756) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2687055) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2687771..2687790) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2687782) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2687805..2687812) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2687819..2688274) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2687819..2688274) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2688227..2688233 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2688248..2688266 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2688256..2690623 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2688256 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2688306..2691536) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2688306..2691536) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2691533..2696020) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2691533..2696020) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2695295..2695301 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2695316..2695334 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2695322..2696284 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2695322 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2696081..2697436) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2696081..2697436) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2696102) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2697451..2697690) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2697451..2697690) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2697760..2698053) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2697760..2698053) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2697770) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2698047 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2698054..2698132) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2698095..2698102 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2698112..2698131) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2698113 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2698117..2698134 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2698132) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2698146..2698153) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2698191..2698196 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2698211..2698230 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2698223..2698329 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2698223 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2698398..2698404 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2698418..2698437 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2698421 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2698526..2698529 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2698538 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2698541..2698560) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2698545..2698564 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2698563) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2698574..2699842 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2698574..2699842 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2698575..2698582) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2699902..2699921 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2699907 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2699944..2701080 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2699944..2701080 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2701080 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2701129..2701137 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2701147 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2701149..2701167 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2701192..2701869 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2701192..2701869 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2701853 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2701913..2702122) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2701913..2702122) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2701925) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2702138..2709274) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2702138..2709274) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2709294..2710232) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2709294..2710232) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2710260..2711879) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2710260..2711879) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2711908..2713104) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2711908..2713104) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2712952..2712959 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2712974..2712993 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2712981 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2713130..2713915) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2713130..2713915) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2713916..2714025) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2714020..2714039) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2714025) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2714027..2714108) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2714053..2714060) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2714109..2714978) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2714109..2714978) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2714979..2715059) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2715043..2715062) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2715059) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2715076..2715083) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2715192..2715788) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2715192..2715788) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2715789..2715873) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2715824..2715831 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2715841 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2715846..2715865 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2715867..2715881) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2715873) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2715889..2715893) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2715889..2716491 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2715889..2716491 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2716477 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2716561..2717889) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2716561..2717889) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2716577) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2717943..2717962) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2717946) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2717977..2717984) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2718036..2719538) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2718036..2719538) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2718051) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2719103..2719117 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2719119 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2719539..2719613) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2719561..2719568 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2719579..2719598 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2719581..2719695 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2719581 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2719608..2719627) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2719618) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2719696..2720172 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2719696..2720172 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2720121 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2720203..2720859) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2720203..2720859) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2720231) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2720507..2720516 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2720530..2720549 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2720547 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2720549..2720995 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2720873) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2720875..2720886) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2720901..2720907) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2720952 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2720963..2721283) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2720963..2721283) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2720977) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2720997..2721207 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2721149..2721249 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2721209..2721318 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2721209 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2721275 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2721302..2721321) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2721307) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2721320..2721871 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2721336..2721343) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2721337..2721480) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2721337..2721480) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2721504..2721523) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2721525) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2721539..2721542) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2721653..2722873) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2721653..2722873) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2721681) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2722874..2723001) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2723001) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2723003..2723067) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2723003..2723021) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2723037..2723042) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2723058..2723077) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2723066) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2723092..2723099) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2723141..2723148 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2723160..2723179 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2723160 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2723205..2724203 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2723205..2724203 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2723228..2723246) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2723243) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2723263..2723268) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2724179 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2724242..2724382) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2724242..2724382) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2724254) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2724383..2724512) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2724493..2724512) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2724512) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2724514..2724761) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2724526..2724532) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2724569..2724576 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2724590..2724609 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2724598 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2724661..2725641 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2724661..2725641 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2724762) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2724766..2724777) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2724791..2724797) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2725609 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2725714) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2725715..2726338) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2725715..2726338) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2726362..2726880) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2726362..2726880) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2726927..2726946) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2726939) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2726941..2727049) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2727036..2727053) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2727047) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2727068..2727075) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2727203) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2727218..2727580) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2727218..2727580) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2727611..2727630) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2727621) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2727644..2727651) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2727659..2728513) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2727659..2728513) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2728229..2728248) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2728237) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2728261..2728270) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2728535..2728554) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2728549) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2728569..2728572) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2728636..2729850) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2728636..2729850) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2729185..2729191 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2729206..2729224 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2729213 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2729217..2729986 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2729887..2729906) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2729892) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2729921..2729928) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2729943 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2729987..2730223) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2729987..2730223) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2729988..2730404 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2730005) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2730188..2730189) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2730193..2730197) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2730195) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2730238..2730257) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2730239) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2730271..2730278) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2730381..2730386 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2730400..2730419 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2730406 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2730486..2731553 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2730486..2731553 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2731537 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2731579..2731905) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2731579..2731905) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2731602) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2731937..2731956) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2731954) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2731969..2731976) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2731989..2731993 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2732005..2732340 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2732005..2732340 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2732006..2732025 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2732011 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2732130) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2732318 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2732382..2734355) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2732382..2734355) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2732394) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2734370..2734388) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2734393) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2734400..2734408) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2734463..2735392) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2734463..2735392) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2734476) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2735389..2736447) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2735389..2736447) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2736447..2737748) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2736447..2737748) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2737633..2737642 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2737657..2737676 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2737664 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2737749..2737830) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2737815..2737834) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2737830) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2737832..2737948) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2737849..2737856) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2737949..2738968) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2737949..2738968) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2738776..2738781 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2738797..2738815 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2738801 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2738991..2739009) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2738998) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2739007..2739012 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2739025..2739030) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2739028..2739092 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2739028..2739046 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2739028 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2739065..2739074 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2739087..2739106 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2739094 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2739121..2739621 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2739121..2739621 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2739648..2740418) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2739648..2740418) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2739676) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2740447..2740881) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2740447..2740881) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2740905..2741180) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2740905..2741180) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2741200..2741219) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2741225) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2741227..2741919) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2741233..2741240) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2741243..2741249 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2741264..2741275 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2741272 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2741295..2741927 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2741295..2741927 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2741888 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2741943..2742839) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2741943..2742839) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2741964) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2742840..2742974) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2742961..2742980) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2742974) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2742996..2743000) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2743014..2743020 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2743034..2743045 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2743046 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2743074..2744054 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2743074..2744054 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2743152) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2743166..2743185) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2743202..2743205) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2744046 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2744082..2744846) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2744082..2744846) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2744098) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2744860..2744878) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2744868) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2744894..2744899) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2744919..2745224) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2744919..2745224) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2744927) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2745238..2745257) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2745261) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2745271..2745279) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2745289..2746677) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2745289..2746677) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2746697..2747518) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2746697..2747518) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2747536..2748384) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2747536..2748384) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2747903..2747908 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2747924..2747942 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2747938 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2748395..2748414) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2748410) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2748422..2748769) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2748422..2748769) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2748782..2748801) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2748801) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2748815..2748821) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2748866..2750206) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2748866..2750206) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2748894) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2749950) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2750263..2750269 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2750283..2750302 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2750285..2750303) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2750291 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2750292..2750380 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2750302) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2750319..2750324) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2750381..2751976 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2750381..2751976 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2752121..2753470 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2752121..2753470 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2753476..2754768 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2753476..2754768 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2754781..2756265 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2754781..2756265 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2756265..2756609 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2756265..2756609 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2756331..2756334 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2756352..2756371 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2756364 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2756584 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2756625..2757012) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2756972..2756981 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2756994..2757013 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2756997 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2757033..2757164) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2757033..2757164 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2757033..2757164 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2757033..2757164) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2757165..2757233 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2757200 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2757370..2757891) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2757370..2757891) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2757882..2760119) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2757882..2760119) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2760120..2760953) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2760120..2760953) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2760950..2761567) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2760950..2761567) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2761059) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2761564..2762556) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2761564..2762556) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2762557..2762643) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2762621..2762640) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2762643) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2762654..2762659) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2762785..2764035) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2762785..2764035) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(2764052..2765290) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(2764052..2765290) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 2765513..2765650 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 2765513..2765650 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 2765672..2765675 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2765690..2765709 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2765691 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 2765732..2766598 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 2765732..2766598 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 2766601 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2766632..2767735) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(2766632..2767735) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(2766647) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2767736..2768669) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 2767773..2767780 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2767794..2767813 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2767804 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2767855..2767861 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2767872 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2767876..2767895 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2767917..2768645 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 2767917..2768645 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(2768670..2769524) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(2768670..2769524) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(2768857..2768876) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2768869) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2769027..2769127) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2769067) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2769538..2770440) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(2769538..2770440) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(2770444..2771322) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(2770444..2771322) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(2771380..2772648) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(2771380..2772648) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 2772539..2772639 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2772599 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2772719) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(2772729..2773715) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(2772729..2773715) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 2773662 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2773665..2773669 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2773758..2773777) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2773771) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2773792..2773799) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2773929) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2773931..2774305) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(2773931..2774305) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(2774369) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2774376..2774387) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2774401..2774407) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2774408..2775526) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(2774408..2775526) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(2775551..2775570) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2775557) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2775559..2776169) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(2775584..2775590) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2775623..2775632 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2775646..2775665 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2775650 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2775663..2775678) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2775667) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2775685..2775689) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2775685..2775831 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 2775685..2775831 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 2775831..2776106 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 2775831..2776106 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(2775975) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2775991..2776005) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2776014..2776018) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2776086 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2776170..2776553) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(2776170..2776553) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(2776554..2776663) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(2776664..2776942) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(2776664..2776942) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(2776940..2776959) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2776964) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2776974..2776981) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2777105..2777211) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(2777148) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2777212..2778609) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(2777212..2778609) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 2778407 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(2778630..2779073) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(2778630..2779073) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(2779063..2780283) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(2779063..2780283) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(2780283..2781596) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(2780283..2781596) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(2781614..2782399) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(2781614..2782399) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(2782443..2782462) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2782444) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(2782476..2782483) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(2782500..2782519) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2782509) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(2782511..2782592) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(2782535..2782539) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(2782556..2782803) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(2782556..2782803) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(2782593..2782730) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(2782593..2782730) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(2782731..2782815) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(2782799..2782818) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2782815) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2782817..2782923) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(2782834..2782837) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2782924..2783301) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(2782924..2783301) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(2783318..2783329) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(2783324) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(2783343..2783349) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(2783386..2784210) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(2783386..2784210) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(2783394) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2783543) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 2783570..2783575 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2783591..2783609 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2783593 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2784224..2784892) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(2784224..2784892) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(2784885..2785910) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(2784885..2785910) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(2785911..2786015) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(2786016..2786122) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(2786016..2786122) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 2786085 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2786149..2786168) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2786161) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2786163..2786236) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(2786184..2786191) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2786237..2786581) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(2786237..2786581) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(2786582..2786687) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(2786688..2787008) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(2786688..2787008) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(2787010..2787450) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(2787010..2787450) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(2787450..2787686) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(2787450..2787686) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(2787462) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(2787701) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2787706..2787717) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2787732..2787738) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2787742..2788125) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(2787742..2788125) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(2788152..2788171) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(2788163) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(2788184..2788191) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(2788192..2788548) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(2788192..2788548) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(2788571..2788590) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(2788581) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(2788604..2788609) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(2788659..2790443) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(2788659..2790443) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(2788669) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2790458..2791633) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(2790458..2791633) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(2791644..2794013) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(2791644..2794013) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 2793432..2793437 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2793452..2793470 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2793455 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2794081..2794100) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(2794084) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(2794092..2794358) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(2794114..2794121) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 2794139..2794145 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2794160..2794171 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2794182 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 2794188..2794334 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 2794188..2794334 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 2794335..2795361 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(2794359..2795267) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(2794359..2795267) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(2795268..2795790) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 2795362..2795607 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 2795362..2795607 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 2795620..2795952 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 2795620..2795952 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(2795773..2795792) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2795790) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2795806..2795815) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2795941 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2796013..2796020 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2796034..2796053 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2796045 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 2796111..2796578 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 2796111..2796578 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 2796575..2798200 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 2796575..2798200 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 2798185 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2798236..2798619) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(2798236..2798619) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(2798638..2799027) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(2798638..2799027) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(2799049..2799378) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(2799049..2799378) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(2799413..2799432) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2799420..2799427 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2799427) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2799442..2799461 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2799446..2799453) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2799452 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 2799512..2800399 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 2799512..2800399 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(2800419..2800706) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(2800419..2800706) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(2800431) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2800731..2801558) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(2800731..2801558) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(2800747) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(2801559..2801696) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(2801681..2801700) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2801696) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2801716..2801719) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2801776..2802213) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(2801776..2802213) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(2802237..2802255) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(2802243) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(2802271..2802276) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(2802323..2803831) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(2802323..2803831) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(2802344) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(2803822..2804118) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(2803822..2804118) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(2804141..2804160) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2804157) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2804175..2804178) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2804195..2804200 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2804212..2804231 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2804212 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 2804252..2805094 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 2804252..2805094 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 2804624..2804630 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 2804645..2804656 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 2804653 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 2805121..2805128 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2805137 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2805140..2805159 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2805184..2805645 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 2805184..2805645 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 2805621 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2805689..2807065) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(2805689..2807065) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(2805697) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2807066..2807237) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(2807218..2807237) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2807237) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2807248..2807255) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2807298..2807317) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 2807308..2807327 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2807310 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2807316) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(2807318..2808381) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(2807332..2807339) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 2807343..2808020 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 2807343..2808020 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 2808017..2809372 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 2808017..2809372 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(2808471..2809399) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 2809340 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2809400..2809564) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(2809400..2809564) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 2809588..2809595 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2809609..2809628 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2809613..2809632) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2809619..2809731 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 2809619 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2809626) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2809628..2809906) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(2809646..2809653) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2809732..2810607 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 2809732..2810607 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(2809896..2809915) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2809906) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2809908..2810449) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(2809929..2809936) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2810441..2810459) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2810449) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2810451..2810580) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(2810472..2810479) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2810582 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(2810625) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(2810643..2812031) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(2810643..2812031) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(2812055) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2812060..2812078) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2812089..2812097) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2812098..2812283) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(2812098..2812283) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 2812287 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2812327..2812346) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2812336..2812342 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2812341) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2812356..2812367 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2812359 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2812362..2812365) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2812401..2813849 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 2812401..2813849 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(2813397..2816040) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 2813818..2814915 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 2813818..2814915 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 2814912..2816033 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 2814912..2816033 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(2816041..2816676) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(2816041..2816676) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(2816654..2817736) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(2816654..2817736) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(2817733..2818458) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(2817733..2818458) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(2818492..2819364) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(2818492..2819364) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(2819383..2819402) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2819403) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2819417..2819420) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2819465..2820142) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(2819465..2820142) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(2819481) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(2820169..2820549) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(2820169..2820549) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(2820572..2820591) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2820592) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2820606..2820609) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2820711..2821979) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(2820711..2821979) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(2820724) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2822013..2822032) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2822024) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2822047..2822054) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2822150) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2822156..2822737) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(2822156..2822737) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(2822760..2824088) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(2822760..2824088) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(2824088..2825149) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(2824088..2825149) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(2825112..2826056) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(2825112..2826056) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(2826057..2826326) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(2826165..2826295) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(2826165..2826295) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(2826303..2826322) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2826326) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2826328..2827255) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(2826338..2826345) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2826388..2826395 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2826410..2826429 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2826414 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 2826454..2827245 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 2826454..2827245 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 2827116 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 2827226 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2827283..2828161) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(2827283..2828161) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(2827300) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2828185..2828203) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2828204) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2828217..2828223) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2828233..2829975) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(2828233..2829975) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(2829972..2830685) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(2829972..2830685) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(2830716..2830735) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2830734) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(2830838..2831077) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(2830838..2831077) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(2830845) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2831073..2831091) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2831081..2831611) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(2831081..2831611) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(2831082) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2831106..2831112) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2831614..2831633) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2831621) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 2831626..2831964 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 2831626..2831964 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(2831648..2831655) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2831664..2831683) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2831676) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2831698..2831704) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2831710..2831810 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 2831770 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 2831938..2832038 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2831998..2832084 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 2831998 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 2832085..2833242 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 2832085..2833242 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 2833228 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 2833303..2833713 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 2833303..2833713 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 2833712 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2833747..2834976) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(2833747..2834976) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(2833764) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2834969..2835658) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(2834969..2835658) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(2835642..2836835) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(2835642..2836835) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(2836879..2836898) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2836892) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2836913..2836920) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2837006..2837815) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(2837006..2837815) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(2837023) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2837162..2837171 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2837184..2837203 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2837188 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2837831..2838841) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(2837831..2838841) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(2838841..2839995) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(2838841..2839995) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(2839928..2839947) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2839945) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2839959..2839966) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2840007..2840014 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2840029..2840048 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2840038 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2840093..2841040 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 2840093..2841040 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 2841016 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 2841060 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2841214 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2841275..2842684) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(2841275..2842684) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(2841290) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2842102..2842106 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2842124..2842140 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2842131 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 2842138..2843105 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(2842786) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(2842788..2842967) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(2842788..2842967) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(2842997..2843014) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2843008) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2843029..2843036) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2843062 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(2843084..2843224) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(2843084..2843224) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(2843094) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(2843252) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(2843254..2843842) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(2843257..2843268) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(2843282..2843288) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 2843314..2843321 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2843335 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2843337..2843356 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2843391..2843873 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 2843391..2843873 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 2843887..2843894 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2843908..2843927 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2843920 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2843973..2845826 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 2843973..2845826 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 2845812 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2845854..2846780) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(2845854..2846780) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(2845866) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2846792..2846811) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2846813) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2846827..2846830) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2846849..2846868 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2846858 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 2846891..2847673 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 2846891..2847673 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 2847645..2848337 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 2847645..2848337 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 2848329 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(2848368..2849198) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(2848368..2849198) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(2848374) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2849061..2849065 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2849081..2849085 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2849090 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2849200 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2849228..2849247) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2849246) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2849262..2849269) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2849354..2849360 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2849374 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2849375..2849393 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2849421..2849906 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 2849421..2849906 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 2849905 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(2849950..2851962) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(2849950..2851962) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(2849958) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2851628..2851632) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2851630) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2851963..2852114) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(2852091..2852109) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2852114) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2852217..2853932) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(2852217..2853932) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(2852224) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(2853958..2855775) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(2853958..2855775) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(2855817..2855836) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2855826..2855833 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2855836) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 2855839 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2855846..2855865 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2855849..2855856) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2855946..2858270) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(2855946..2858270) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(2855964) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2858290..2858297 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2858312..2858331 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2858313..2858328) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2858316 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2858318) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2858363..2858382) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2858372) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2858398..2858404) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2858408..2858427) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2858428) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2858441..2858449) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2858455) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(2858468..2859076) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(2858468..2859076) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(2859115..2859134) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2859132) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2859150..2859154) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2859263..2859679) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(2859263..2859679) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(2859273) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2859684..2860352) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(2859684..2860352) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(2860404..2860423) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2860419) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2860430) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2860437..2860442) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2860472..2862580) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(2860472..2862580) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(2862572..2862673) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(2862667..2862686) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2862673) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2862702..2862709) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2862740..2865148) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(2862740..2865148) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(2862762) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2862828) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2865149..2865231) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(2865232..2865441) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(2865232..2865441) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(2865465..2865484) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(2865486) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(2865497..2865503) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(2865515..2865820) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(2865515..2865820) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 2865784..2865803 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2865795 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2865834..2865853) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(2865860) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(2865867..2865873) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 2865912..2865918 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2865933..2865951 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2865941 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2865948..2867024 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 2865948..2867024 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 2867011 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2867061..2867696) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(2867061..2867696) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(2867074) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2867697..2867794) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(2867774..2867793) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2867794) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2867807..2867813) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2867856..2869751) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(2867856..2869751) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(2869802..2869813) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2869802) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2869828..2869834) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2869901) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2869914..2870315) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(2869914..2870315) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(2870312..2870671) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(2870312..2870671) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(2870668..2871240) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(2870668..2871240) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(2871278..2871297) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2871283) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2871311..2871318) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2871351..2872145) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(2871351..2872145) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(2872166..2872184) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2872178) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2872199..2872205) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2872211..2872230) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2872222) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2872224..2872289) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(2872244..2872251) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2872331..2872690) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(2872331..2872690) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(2872334) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2872674..2872682) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2872684) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2872697..2872702) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2872742..2872761) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2872750) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2872752..2872816) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(2872774..2872778) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2872816) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(2872817..2872836) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(2872851..2872858) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(2872867..2873337) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(2872867..2873337) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 2873164..2873264 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2873224 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2873334 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2873382..2873401) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2873388) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(2873390..2873481) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(2873417..2873420) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(2873482..2875821) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(2873482..2875821) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 2874582..2874585 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2874601..2874604 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2874610 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2875840..2876580) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(2875840..2876580) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(2876236..2876254) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(2876248) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(2876269..2876275) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(2876608..2876626) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2876622) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(2876710) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(2876712..2876942) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(2876712..2876942) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(2876972..2876991) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2876993) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(2877006..2877009) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 2877031..2877037 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2877051..2877062 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2877052 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 2877091..2877861 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 2877091..2877861 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 2877113..2877121 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2877132..2877150 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2877162 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2877901..2878134) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(2877901..2878134) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 2878225..2878232 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 2878240 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 2878244..2878263 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 2878286..2878693 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 2878286..2878693 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 2878723..2879142 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 2878723..2879142 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 2879180..2879187 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2879201..2879220 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2879208 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2879234..2879560 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 2879234..2879560 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 2879561..2879645 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 2879616..2879623 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2879636..2879654 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2879647 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2879685..2881385 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 2879685..2881385 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(2880401..2881394) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 2881363 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2881425..2882105) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(2881425..2882105) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(2881439) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2881799..2881805 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2881820..2881838 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2881825..2884576 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 2881825 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2882122..2883042) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(2882122..2883042) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(2883054..2883707) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(2883054..2883707) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(2883724..2884869) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(2883724..2884869) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(2884870..2884937) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(2884937) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2884938..2884957) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2884968..2884972 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2884972..2884975) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2884988..2885006 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2884993 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2885088..2885092 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2885108..2885127 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2885111 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 2885153..2885686 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 2885153..2885686 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(2885353..>2885752) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 2885675 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2885752,2885759) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs14" N_region 2885753..2885758 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs14" S_feature <2885759..2885834 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" S_feature complement(<2885759..2885825) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" CDS complement(2885830..2886519) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(2885830..2886519) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(2885870) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 2886462..2886470 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2886484..2886503 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2886498 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2886537..2887448) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(2886537..2887448) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(2887468..2888121) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(2887468..2888121) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(2888144..2889286) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(2888144..2889286) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(2889330..2889349) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(2889345) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(2889364..2889367) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 2889483..2889490 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2889503..2889522 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2889514 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 2889550..2890107 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 2889550..2890107 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 2890108..2890872 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(2890125..2890760) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(2890125..2890760) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(2890138) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2890801..2890819) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2890807) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2890835..2890841) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2890846..2890853 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2890865..2890884 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2890874 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2890910..2891524 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 2890910..2891524 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 2891510 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 2891578..2891581 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2891596..2891615 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2891604 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2891656..2892354 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 2891656..2892354 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 2892327 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2892390..2894207) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(2892390..2894207) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(2892409) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2892580) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(2894249..2894268) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 2894253..2894272 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2894258 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2894262) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2894327..2894794 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 2894327..2894794 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 2894791 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2894839..2896131) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(2894839..2896131) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(2894849) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2896161..2897696) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(2896161..2897696) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(2897689..2898450) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(2897689..2898450) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(2898481..2899665) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(2898481..2899665) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(2899666..2899906) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(2899906) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2899908..2899981) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(2899920..2899939) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2899955..2899959) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2899982..2900989) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(2899982..2900989) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 2900908..2900911 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2900928..2900930 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2900930 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2901036..2902058) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(2901036..2902058) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(2901052) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2901080..2901081) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2902059..2902170) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 2902096 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2902151..2902170) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2902170) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2902172..2902282) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(2902184..2902191) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2902265..2902284) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(2902280) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(2902297..2902306) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(2902356..2903750) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(2902356..2903750) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(2902370) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2903849..2903868) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2903863) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2903883..2903890) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2903890..2903897 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2903911..2903930 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2903917 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 2903954..2905042 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 2903954..2905042 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 2905022 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2905091..2906101) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(2905091..2906101) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(2905098) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2906102..2906179) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(2906169..2906188) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2906179) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2906202..2906209) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2906258..2907136) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(2906258..2907136) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 2906794..2906800 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2906815..2906826 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2906826 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2907170..2907177 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2907183..2907202) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(2907188) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 2907191..2907210 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2907193 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2907216..2907220) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 2907236..2908153 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 2907236..2908153 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 2908142 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2908194..2909537) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(2908194..2909537) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(2909606..2909841) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(2909606..2909841) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(2909740) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2909842..2909938) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(2909939..2910973) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(2909939..2910973) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(2910995..2911013) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2911001) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2911026..2911033) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2911081..2911803) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(2911081..2911803) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(2911097) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(2911803..2913242) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(2911803..2913242) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 2912790..2912793 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2912810 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2912811..2912815 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2912964 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 2913118 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2913119..2913120 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2913269..2913985) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(2913269..2913985) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 2913889..2913896 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2913910..2913912 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2913910 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2913983 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(2913986..2914052) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(2914049..2914068) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(2914052) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(2914083..2914090) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(2914160..2914762) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(2914160..2914762) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(2914779..2915894) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(2914779..2915894) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(2915898..2916635) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(2915898..2916635) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(2915924..2915943) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(2915938) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(2915955..2915962) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(2916636..2917541) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(2916636..2917541) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(2917561..2917579) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2917572) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2917595..2917598) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2917750..2917757 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2917768..2917787 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2917775 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 2917825..2918634 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 2917825..2918634 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 2918670..2919881 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 2918670..2919881 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 2919868 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2919935..2921224) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(2919935..2921224) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(2921304..2923367) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(2921304..2923367) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(2923386..2924237) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(2923386..2924237) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(2924241..2925497) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(2924241..2925497) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(2925537..2926802) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(2925537..2926802) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(2926834..2926853) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2926856) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2926868..2926875) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2926943..2927935) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(2926943..2927935) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(2926977) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(2928065..2928114) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(2928088) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2928115..2928774) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(2928115..2928774) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(2928775..2928880) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(2928872..2928891) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2928881) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2928906..2928909) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2928933..2928940 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2928955..2928974 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2928955 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 2928958..2929063 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(2928964..2928981) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2928968) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2928989..2928995) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2929064..2930755 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 2929064..2930755 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 2930740 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2930782..2932092) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(2930782..2932092) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 2930785..2931855 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(2930794) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2931912..2931931 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2931912..2932170 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 2931912 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2932106..2932125) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2932121) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2932140..2932143) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2932171..2932389 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 2932171..2932389 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 2932368 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" SCAR join(2932396,2932403) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs26" N_region 2932397..2932402 /note="EcoR site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs26" promotor_-35 2932434..2932437 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2932443 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2932454..2932472 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2932488..2933957 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 2932488..2933957 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 2933934 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 2933960..2934151 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 2933960..2934151 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 2934130 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2934178..2934663) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(2934178..2934663) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(2934686..2934997) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(2934686..2934997) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(2935049..2935141) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(2935049..2935141) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(2935181..2935200) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2935198) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2935214..2935221) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2935272..2935955) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(2935272..2935955) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(2935290) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(2935971..2937326) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(2935971..2937326) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(2937338..2937353) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2937354) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2937365..2937374) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2937628..2937635 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2937649..2937668 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2937652 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 2937674..2937864 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 2937865..2939286 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 2937865..2939286 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 2939280 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2939360..2940910 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 2939360..2940910 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 2940954..2940960 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2940974..2940985 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2940974 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 2941018..2942580 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 2941018..2942580 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 2942558 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2942570..2943259 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 2942570..2943259 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 2942609..2942616 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2942630..2942649 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2942639 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 2943240 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(2943338) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 2943341..2943676 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 2943341..2943676 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 2943676..2943996 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 2943676..2943996 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 2943997..2944187 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(2944032..2944544) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(2944032..2944544) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 2944164 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2944580..2944591) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2944586) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2944606..2944612) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2944659..2944795) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(2944702) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(2944796..2946139) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(2944796..2946139) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(2946168..2946187) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2946176) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2946200..2946209) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2946201..2946206 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2946222..2946240 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2946225 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2946434..2946443 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2946452 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2946457..2946476 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2946495..2947457 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 2946495..2947457 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 2947458..2947711 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(2947738) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(2947742..2947817) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(2947742..2947817) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(2947844..2947863) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2947865) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2947879..2947882) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2947948..2947954 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2947964..2948039 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 2947964 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2947969..2947988 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2948016..2948023 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2948037..2948056 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2948041 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 2948087..2948680 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 2948087..2948680 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 2948669 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 2948714..2949112 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(2948726..2949406) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(2948726..2949406) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(2948750) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(2949403..2951088) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(2949403..2951088) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(2951081..2953354) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(2951081..2953354) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(2953332..2954216) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(2953332..2954216) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(2954222..2955058) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(2954222..2955058) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(2955059..2956366) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(2955059..2956366) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 2955424..2955433 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2955446..2955465 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2955450 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2956406..2957659) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(2956406..2957659) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(2957660..2957754) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(2957755..2959524) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(2957755..2959524) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 2959445..2959450 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2959466..2959484 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2959476 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2959562..2959581) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2959575) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2959594..2959601) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2959637..2960587) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(2959637..2960587) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(2960602..2960620) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2960615) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2960632..2960640) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2960721) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2960793..2961368) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(2960793..2961368) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(2960805) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2961411..2961430) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2961417..2961424 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2961427) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 2961434 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2961437..2961456 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2961445..2961452) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2961485..2961805 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 2961485..2961805 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 2961786 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2961832) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2961832..2963424) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(2961832..2963424) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(2963443..2964036) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(2963443..2964036) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(2964078..2964097) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2964091) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2964112..2964116) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2964162..2964167 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2964183..2964201 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2964184 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2964357..2964364 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2964378..2964397 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2964382 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 2964419..2965396 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 2964419..2965396 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 2965368 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2965434..2967374) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(2965434..2967374) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(2965458) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(2967349..2968128) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(2967349..2968128) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(2968129..2968210) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(2968211..2969281) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(2968211..2969281) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(2969275..2969988) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(2969275..2969988) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(2970034..2970053) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2970046) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2970048..2970309) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(2970066..2970069) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2970069..2970076 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2970087..2970106 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2970092 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2970135..2970344 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 2970135..2970344 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 2970322 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2970354) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2970380..2971144) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(2970380..2971144) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(2970402) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2971145..2971402) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(2971145..2971402) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(2971426..2972376) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(2971426..2972376) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(2972399..2973352) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(2972399..2973352) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(2973354..2974241) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(2973354..2974241) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(2974266..2974742) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(2974266..2974742) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(2974762..2974781) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2974776) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2974797..2974801) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2974820..2974839) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2974833) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2974854..2974857) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2974909..2975059) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(2974952) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(2975060..2976010) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(2975060..2976010) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(2976011..2976098) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(2976087..2976106) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2976098) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2976100..2976191) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(2976121..2976124) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2976139..2976145 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2976159..2976177 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2976173 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 2976174..2979560 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(2976216..2977637) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(2976216..2977637) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(2976236) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(2976360) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 2977264..2977268 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2977274 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2977553..2977557 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2977560 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2977638..2977835) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 2977758 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2977823..2977842) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(2977835) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(2977854..2977861) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(2978018..2979472) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(2978018..2979472) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(2978038) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(2979473..2979597) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 2979518 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2979598..2981367) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(2979598..2981367) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(2981368..2981442) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(2981431..2981450) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2981442) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(2981532..2981891) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(2981532..2981891) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(2981552) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2981906..2983816) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(2981906..2983816) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(2983818..2984543) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" /label="yvcA CDS" gene complement(2983818..2984543) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /label="yvcA gene" S_feature complement(2984544..2984632) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(2984632..2984651) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2984632) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2984634..2984763) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(2984667..2984670) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2984789..2985418) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(2984789..2985418) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(2984808) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(2985415..2986173) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(2985415..2986173) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(2986170..2986907) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(2986170..2986907) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(2986904..2987542) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(2986904..2987542) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 2987400..2987500 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2987460 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2987543..2988127) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(2987543..2988127) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(2988124..2989407) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(2988124..2989407) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(2989404..2990045) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(2989404..2990045) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(2990038..2991213) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(2990038..2991213) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(2991214..2991291) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 2991257..2991263 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2991275..2991294 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2991275..2991294) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2991288 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2991291) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2991307..2991314) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2991423..2991442 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2991430 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 2991464..2992216 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 2991464..2992216 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 2992217..2992455 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(2992238..2992249) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2992244) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2992264..2992270) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2992456..2993121 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 2992456..2993121 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 2993092 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2993141..2993659) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(2993141..2993659) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(2993175) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2993663..2994313) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(2993663..2994313) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(2994310..2995248) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(2994310..2995248) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(2995272..2996081) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(2995272..2996081) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(2996095..2997027) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(2996095..2997027) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(2997069..2997088) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2997075) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2997104..2997109) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2997144..2997151 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2997163 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2997166..2997183 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2997209..2998399 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 2997209..2998399 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 2998197..2998203 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2998218 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2998219..2998237 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2998396..2999124 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 2998396..2999124 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 2999142..2999873 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 2999142..2999873 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(2999893..3003762) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(2999893..3003762) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(3000015) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3003782..3003793) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3003789) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3003808..3003814) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3003852..3003858 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3003872..3003891 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3003877 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 3003927..3004400 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 3003927..3004400 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 3004401..3004508 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3004441..3005658) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(3004441..3005658) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(3004454) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3004480..3004485 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3004500..3004511 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3004510..3004795 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3004510 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 3004752 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3005674..3006420) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(3005674..3006420) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(3006421..3006607) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3006593..3006612) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3006607) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3006626..3006633) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3006741..3006748 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3006763..3006782 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3006775 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 3006776..3006845 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3006846..3007355 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 3006846..3007355 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(3007251..3008589) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3007292) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3007376..3008587 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 3007376..3008587 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 3008585 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(3008615..3008974) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(3008615..3008974) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 3008630..3009346 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3008634) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3008976..3009173) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(3008976..3009173) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(3009178..3010275) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(3009178..3010275) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(3010300..3010626) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(3010300..3010626) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(3010679..3010694) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3010694) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3010696..3011186) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3010706..3010715) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3010774..3010777 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3010792..3010811 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3010802 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 3010844..3011074 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 3010844..3011074 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(3011177..3011196) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3011187) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(3011212..3011216) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3011273..3011755) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(3011273..3011755) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 3011281 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(3011296) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3011428) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3011436..3011439) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3011516..3011520) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3011516) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3011536..3011539) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3011756..3011889) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3011917..3014790) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(3011917..3014790) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(3011934) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3014798..3016783) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(3014798..3016783) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(3016817..3016836) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3016829) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3016831..3016916) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3016848..3016855) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3016961) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(3016969..3017199) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(3016969..3017199) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(3017226..3017245) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3017236) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(3017238..3017302) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3017259..3017266) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3017279..3017297) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3017300) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3017312..3017318) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3017368) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(3017394..3017494) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3017434) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3017516..3017523 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3017537..3017556 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3017554 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3017646..3020141 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 3017646..3020141 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 3020156..3020160 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3020174 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 3020217..3020786 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 3020217..3020786 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 3020817..3022151 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 3020817..3022151 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 3022132 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(3022199..3023392) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(3022199..3023392) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(3022208) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(3022273) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(3023393..3023470) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3023396) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(3023471..3023809) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(3023471..3023809) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(3023784..3023900) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(3023784..3023900) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(3023901..3023990) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3023972..3023990) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3023990) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3023992..3024072) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3024004..3024009) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3024058..3024076) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3024072) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3024090..3024097) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3024209..3025651) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(3024209..3025651) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(3024298) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3025697..3025708) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3025708) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3025723..3025729) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3025791..3026681) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(3025791..3026681) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(3025808) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(3026674..3027360) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(3026674..3027360) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(3027361..3027493) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3027483..3027502) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3027493) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3027517..3027520) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3027594..3027932) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(3027594..3027932) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(3027595) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3027959..3027978) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3027972) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(3027981..3028865) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(3027981..3028865) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(3027992..3027999) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3028853..3028872) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3028874) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(3028887..3028894) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3030022..3030093), complement(3028992..3030020)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(3028992..3030093) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(3029008) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(3030094..3030162) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3030163..3032688) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(3030163..3032688) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(3032689..3032769) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3032759..3032778) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3032769) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3032856..3033425) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(3032856..3033425) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(3032864) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 3033392..3033398 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3033411..3033430 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3033418 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3033452..3033470) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3033460) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3033462..>3033563) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3033482..3033490) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 3033563..3033564 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_008" CDS complement(3033567..3034049) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(3033567..3034049) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(3034065..3034331) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(3034065..3034331) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(3034332..3034411) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3034412..3034831) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(3034412..3034831) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(3034870..3034888) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3034881) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3034902..3034909) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3034905..3035627) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(3034905..3035627) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(3035591..3035887) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(3035591..3035887) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(3035913..3035932) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3035926) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3035943..3035950) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3035947..3037338) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(3035947..3037338) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(3037352..3037371) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3037367) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3037385..3037392) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3037444..3038289) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(3037444..3038289) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(3037455) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3037706..3037713 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3037727..3037746 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3037737..3039469 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3037737 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3038316..3038335) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3038335) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3038350..3038353) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3038387..3039076) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(3038387..3039076) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(3038401) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(3039077..3039158) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3039159..3040316) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(3039159..3040316) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(3040317..3040444) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3040364..3040367 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3040382..3040401 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3040393..3040479 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3040393 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3040438..3040457) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3040444) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3040461..3040469 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3040468..3040475) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3040481 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3040483..3040491 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3040533..3041186 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 3040533..3041186 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(3040889..3041481) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3041186..3042361 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 3041186..3042361 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(3041477..3041495) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3041486) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3041509..3041515) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3042333 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3042434..3043510) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(3042434..3043510) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(3042450) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3042496..3042505 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3042519..3042538 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3042527..3043760 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3042527 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3043511..3043593) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3043581..3043600) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3043593) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3043612..3043618) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3043655..3044848) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(3043655..3044848) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(3043685) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(3044877..3045635) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(3044877..3045635) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(3045659..3046339) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(3045659..3046339) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(3046368..3047834) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(3046368..3047834) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(3047835..3047918) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3047919..3049304) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(3047919..3049304) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(3049366..3050535) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(3049366..3050535) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(3050532..3051983) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(3050532..3051983) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(3052039..3052188) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(3052039..3052188) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(3052133..3052672) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(3052133..3052672) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(3052728..3052745) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3052732) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3052899..3054389) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(3052899..3054389) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(3052921) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3054428..3056545) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(3054428..3056545) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(3056569..3056877) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(3056569..3056877) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 3056783 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 3056873..3056877 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3056886..3056900 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3056887..3056905) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3056893 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3056919..3056926) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3056922) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3056943..3056951 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3056965..3056978 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3056983 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 3057061..3057981 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 3057061..3057981 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 3057971 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3058021..3059163) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(3058021..3059163) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(3058045) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3059202..3059221) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3059216) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3059236..3059239) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3059292..3059296 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3059312..3059331 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3059313..3059408 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3059314 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 3059409..3060287 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 3059409..3060287 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 3060288..3061379 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3060357..3060712) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3060621..3060839 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 3060621..3060839 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(3060713..3060796) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(3060713..3060796) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(3060797..3060988) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3060989..3063691) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(3060989..3063691) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(3063692..3063814) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3063713..3063719 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3063734..3063752 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3063739..3066571 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3063739 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3063815..3065155) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(3063815..3065155) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(3065196..3065402) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(3065196..3065402) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(3065403..3066276) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3066270..3066289) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3066276) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3066278..3066517) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3066302..3066308) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3066499..3066517) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3066517) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(3066531..3066538) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3066540..3066547 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3066559..3066578 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3066573..3066703 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3066573 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3066645..3066745 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3066705 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 3066709..3067305 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 3066709..3067305 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 3066903 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3067344..3068927) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(3067344..3068927) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 3067387 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(3068947..3069774) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(3068947..3069774) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(3069775..3069839) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3069835..3069854) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3069839) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3069841..3069938) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3069870..3069873) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3069939..3072179) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(3069939..3072179) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(3072179..3074200) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(3072179..3074200) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 3072942..3072951 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3072964..3072979 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3072975 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3074201..3074360) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3074361..3074750) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(3074361..3074750) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(3074751..3074885) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3074869..3074888) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3074885) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3074899..3074906) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3075040..3075046 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3075057..3075149 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3075057 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3075058..3075077 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3075150..3075920 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 3075150..3075920 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(3075277..3075625) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3075629..3075640) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3075633) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3075655..3075661) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3075945 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 3075953..3077098 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 3075953..3077098 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 3077086 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 3077140..3077147 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3077162..3077181 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3077172 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 3077218..3078546 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 3077218..3078546 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 3078541 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3078602) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" SCAR 3078626..3078627 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_002" downshifts 3078650 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3078703..3079944) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(3078703..3079944) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(3078722) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3079966..3079984) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3079988) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3079997..3080004) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3080085..3080252) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(3080085..3080252) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(3080112) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(3080267..3081409) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(3080267..3081409) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(3081428..3081877) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(3081428..3081877) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 3081571..3081577 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3081585 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 3081591..3081609 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3081598..3083807 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3081892..3083073) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(3081892..3083073) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 3083787..3083794 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3083809 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3083810..3083829 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3083830) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3083835..3083849) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3083857..3083861) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3083857..3084837 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 3083857..3084837 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 3084686..3084693 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3084707..3084726 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3084722 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 3084839..3085720 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 3084839..3085720 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 3085717..3086112 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 3085717..3086112 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 3086128..3087609 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 3086128..3087609 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 3087611..3088579 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 3087611..3088579 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 3088591..3089508 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 3088591..3089508 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 3089517..3089523 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3089538..3089556 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3089540 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 3089590..3090126 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 3089590..3090126 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 3090109 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 3090154..3090264 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3090233..3090239 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3090254..3090265 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3090266 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3090282..3090578 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 3090282..3090578 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 3090579..3091231 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3090618..3091145) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(3090618..3091145) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(3090628) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3091165..3091184) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3091178) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3091189 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3091198..3091205) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3091244) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3091245..3092012) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3091245..3092012) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3092074..3093786) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3092074..3093786) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3092685..3092694 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3092708..3092727 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3092708 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3093840..3093859) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3093845) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3093865..3093872 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3093874..3093878) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3093886..3093905 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3093896 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3093944..3094852 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3093944..3094852 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3094920..3094928 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3094930..3095062 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3094930 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3094942..3094961 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3095063..3096391 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3095063..3096391 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3096382 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3096448..3097125) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3096448..3097125) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3096458) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3097185..3098327) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3097185..3098327) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3098364..3098383) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3098372) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3098374..3098454) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3098397..3098405) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3098455..3099543) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3098455..3099543) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3099544..3099657) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3099599..3099608 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3099621..3099640 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3099634 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3099657) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3099661..3099675) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3099684..3099688) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3099684..3100271 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3099684..3100271 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3099772..3100251 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3099772..3100251 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3100155..3100352) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3100188 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3100198) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3100257 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3100336 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3100351..3100370) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3100357) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3100379..3100386 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3100383..3100392) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3100401..3100420 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3100407 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3100445..3101062 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3100445..3101062 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3101063..3101163 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3101120 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3101189..3101198 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3101210..3101225 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3101211 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3101240..3101575 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3101240..3101575 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3101531..3101549) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3101540) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3101564..3101569) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3101574 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3101580..3103157) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3101580..3103157) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3101619..3103330 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3103308..3103315 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3103326..3103345 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3103332 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3103371..3103847 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3103371..3103847 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3103861..3104454 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3103861..3104454 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3104451..3104987 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3104451..3104987 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3104968 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3105014..3105235) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3105014..3105235) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3105182 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3105189..3105190 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3105232..3105777) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3105232..3105777) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3105794..3105801 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3105816..3105835 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3105820 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3105900..3106781 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3105900..3106781 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3106866..3107582) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3106866..3107582) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3106886) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3107592..3108056) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3107592..3108056) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3108046..3109854) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3108046..3109854) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3109873..3110133) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3109873..3110133) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3110143..3110565) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3110143..3110565) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3110566..3110648) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3110640..3110659) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3110648) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3110672..3110679) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3110782..3110907) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3110782..3110907) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3110825..3110956) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3110868) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3110957..3111742) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3110957..3111742) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3111743..3111858) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3111851..3111870) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3111858) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3111884..3111891) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3111934..3113256) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3111934..3113256) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3111946) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3113290) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3113292..3113417) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3113292..3113310) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3113326..3113331) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3113397..3113416) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3113417) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3113451..3114215) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3113451..3114215) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3114234) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3114268..3114981) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3114268..3114981) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3114285) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3114971..3115717) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3114971..3115717) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3115749..3115768) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3115761) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3115785..3115788) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3115951..3116094) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3115951..3116094) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3115972) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3116095..3116180) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3116170..3116181) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3116180) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3116182..3116412) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3116219..3116223 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3116239..3116258 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3116248 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3116298..3117908 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3116298..3117908 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3116400..3116418) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3116412) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3116414..3116588) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3116432..3116439) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3116575..3116594) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3116588) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3116608..3116616) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3117895..3120663 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3117895..3120663 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3120712) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3120789..3121646) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3120789..3121646) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3121652..3122428) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3121652..3122428) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3122454..3122473) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3122476) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3122478..3122550) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3122488..3122495) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3122552..3122651) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3122595) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3122652..3122993) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3122652..3122993) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3123015..3123034) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3123034) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3123048..3123055) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3123070..3123453) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3123070..3123453) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3123475..3123494) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3123482..3123501 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3123486 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3123495) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3123509..3123516) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3123576..3123595 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3123579 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3123628) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3123628..3124038 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3123628..3124038 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3124039..3124122 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3124080 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3124178..3124486) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3124178..3124486) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3124179) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3124830..3125666 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3124830..3125666 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3125046..3125053 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3125068..3125087 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3125071 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3125665 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3125713..3126105) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3125713..3126105) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3125719) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3126178..3126603) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3126178..3126603) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3126664..3126683) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3126680) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3126682..3126766) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3126698..3126705) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3126745 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3126748..3126767 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3126758..3126777) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3126766) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3126768..3127852) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3126791..3126796) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3126795..3127859 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3126795..3127859 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3127860..3128744 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3127882..3128691) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3127882..3128691) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3127897) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3128725..3129537) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3128725..3129537) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3129538..3129617) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3129568..3129575 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3129589..3129608 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3129598 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3129611..3129629) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3129617) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3129643..3129650) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3129700..3130701) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3129700..3130701) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3129706) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3130756..3130775) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3130780) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3130782..3130866) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3130867..3131148) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3130867..3131148) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3131163..3131273) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3131163..3131273) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3131304..3131322) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3131326) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3131338..3131343) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3131419..3131425 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3131439..3131458 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3131455 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3131498..3131911 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3131498..3131911 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3131933..3133123 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3131933..3133123 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3133214..3134620) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3133214..3134620) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3133511) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3134653..3134672) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3134671) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3134687..3134690) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3134726..3136198) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3134726..3136198) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3136379..3137737) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3136379..3137737) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3136393) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3137737..3138306) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3137737..3138306) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3138325..3138336) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3138343) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3138350..3138356) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3138413..3138580) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3138413..3138580) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3138490..3138954) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3138490..3138954) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3138984..3139003) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3138989) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3139017..3139024) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3139155..3139158 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3139173..3139192 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3139177 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3139236..3140450 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3139236..3140450 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3140066..3140084) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3140067) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3140098..3140105) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3140316..3140322 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3140336..3140355 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3140338 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3140462..3140812 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3140462..3140812 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3140805 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3140864..3140872 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3140886..3140894 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3140893 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3140935..3140944 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3140957..3140972 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3140961 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3140993..3141574 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3140993..3141574 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3141091..3141110) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3141101) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3141124..3141132) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3141555 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3141615..3142037) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3141615..3142037) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3141634) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3142072..3142087) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3142091) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3142100..3142109) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3142148..3142999) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3142148..3142999) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3142157) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3142399) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3142636..3142638 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3142655..3142674 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3142656..3143002 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3142656 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3142994..3142997 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3143004..3143139 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3143004 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3143033) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3143039..3143048) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3143140..3143631 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3143140..3143631 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3143369..3143374 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3143390..3143408 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3143401 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3143492..3144400) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3143628..3144146 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3143628..3144146 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3143951 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3144149 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3144305..3144436 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3144305..3144436 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3144433..3144867) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3144433..3144867) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3144445) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3144916..3144935) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3144923) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3144925..3145222) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3144950..3144957) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3144996..3145000 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3145017..3145036 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3145029..3145109 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3145030 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3145110..3146558 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3145110..3146558 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3145222) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3145223..3145241) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3145224..3145567) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3145257..3145263) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3145545..3145563) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3145567) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3145579..3145584) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3146547 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3146579..3147352) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3146579..3147352) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3146601) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3147427..3147430 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3147446..3147465 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3147450 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3147497..3147880 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3147497..3147880 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3147867 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3147915..3148556) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3147915..3148556) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3147965) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3148624..3149025) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3148624..3149025) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3149074..3149093) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3149084) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3149086..3149159) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3149108..3149113) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3149160..3150869) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3149160..3150869) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3150866..3151240) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3150866..3151240) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3151237..3151554) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3151237..3151554) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3151555..3151639) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3151639) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3151641..3151654) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3151641..3151734) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3151735..3151899) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3151735..3151899) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3151822..3151840) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3151834) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3151852..3151860) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3151900..3152071) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3152072..3152254) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3152072..3152254) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3152255..3152401) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3152389..3152408) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3152401) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3152403..3152517) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3152423..3152430) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3152504,3152506) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3152531 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3152534..3152538 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3152551..3152739) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3152551..3152739) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3152562) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3152729 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3152765..3152783) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3152776) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3152797..3152803) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3152812..3153312) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3152812..3153312) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3153348..3153367) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3153355) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3153381..3153387) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3153447..3154580) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3153447..3154580) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3153465) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3154607..3154626) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3154614) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3154677..3154695) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3154693) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3154709..3154716) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3154772..3155797) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3154772..3155797) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3154785) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3155813..3156601) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3155813..3156601) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3156627..3156646) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3156633) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3156635..3156846) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3156660..3156667) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3156847..3157008) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3156847..3157008) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3157021..3157039) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3157041) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3157053..3157059) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3157102..3157776) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3157102..3157776) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3157117) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3157829..3157969) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3157829..3157969) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3158100..3158783) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3158100..3158783) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3159160..3159164 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3159169..3160200) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3159169..3160200) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3159179..3159198 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3159185) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3159197 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3160228..3160246) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3160241) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3160243..3160360) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3160262..3160267) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3160302..3160307 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3160319..3162979 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3160319 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3160323..3160341 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3160396..3161706) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3160396..3161706) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3160405) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3161730..3161749) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3161737) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3161740..3162480) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3161740..3162480) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3161763..3161772) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3162111) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3162113..3162121) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3162135..3162143) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3162235..3162250) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3162243) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3162263..3162272) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3162481..3162608) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3162609..3162839) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3162609..3162839) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3162840..3163102) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3162975..3162994 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3162981 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3163009..3163482 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3163009..3163482 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3163086..3163105) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3163102) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3163104..3163487) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3163120..3163123) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3163516..3163914) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3163516..3163914) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3163532) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3163906..3163924) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3163915) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3163938..3163944) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3163938..3165359) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3163938..3165359) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3165385..3166248) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3165385..3166248) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3166249..3166324) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3166325..3167833) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3166325..3167833) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3167850..3168395) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3167850..3168395) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3168392..3168904) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3168392..3168904) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3168905..3169066) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3169067..3169279) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3169067..3169279) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3169325..3170059) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3169325..3170059) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3169873..3169973 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3169933 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3170067..3170450) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3170067..3170450) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3170139..3170157) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3170141) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3170451..3170721) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3170683..3170692 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3170692 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3170697..3170716) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3170706..3170725 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3170721) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3170723..3170844) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3170729..3170736) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3170873..3171502) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3170873..3171502) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3170889) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3171546..3171565) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3171569) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3171580..3171587) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3171637..3172884) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3171637..3172884) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3171660) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3172926..3172945) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3172943) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3172945..3173029) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3172960..3172965) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3173074) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3173091..3173633) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3173091..3173633) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3173646..3174095) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3173646..3174095) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3174096..3174195) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3174187..3174206) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3174195) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3174220..3174227) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3174252..3174704) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3174252..3174704) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3174721..3174740) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3174739) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3174755..3174758) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3174780..3175337) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3174780..3175337) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3175364..3175382) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3175377) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3175398..3175403) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3175416..3176456) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3175416..3176456) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3175421) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3176457..3176521) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3176511..3176530) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3176521) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3176523..3176612) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3176546..3176550) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3176613..3177056) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3176613..3177056) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3177123..3177797) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3177123..3177797) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3177559..3177577) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3177566) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3177592..3177598) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3177829..3177846) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3177830) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3177862..3177867) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3177903 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3177907..3177926 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3177938..3178300 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3177938..3178300 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3178313) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3178317..3178604) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3178317..3178604) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3178605..3178663) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3178661..3178680) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3178664..3179530) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3178664..3179530) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3178677) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3178693..3178702) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3179532..3180602) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3179532..3180602) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3179535) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3180603 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3180630..3180649) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3180654) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3180656..3180767) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3180663..3180669) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3180699..3180718 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3180713 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3180728..3181114 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3180728..3181114 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3180749..3180767) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3180767) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3180781..3180788) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3181182..3181190 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3181201..3181219 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3181202 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3181236..3181790 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3181236..3181790 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3181720..3181724 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3181725 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3181769 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3181824..3182783) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3181824..3182783) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3181846) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3182821..3182839) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3182835) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3182854..3182860) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3182865..3184613) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3182865..3184613) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3183339..3183357) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3183347) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3183372..3183378) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3184614..3184704) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3184688..3184707) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3184704) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3184721..3184728) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3184847) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3184852..3185439) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3184852..3185439) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3185528..3185728) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3185528..3185728) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3185541) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3185729..3185806) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3185802..3185821) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3185806) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3185835..3185842) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3185847..3187130) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3185847..3187130) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3187131..3187433) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3187161..3187322) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3187161..3187322) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3187413..3187432) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3187433) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3187448..3187452) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3187537..3188502) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3187537..3188502) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3187543) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3188119..3188128 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3188141..3188160 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3188149 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3188533..3189822) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3188533..3189822) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3189823..3190182) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3190201..3190839) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3190201..3190839) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3190227) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3190840..3190958) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3190959..3191816) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3190959..3191816) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3191817..3191943) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3191925..3191944) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3191943) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3191958..3191965) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3191997..3192371) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3191997..3192371) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3192411..3192429) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3192425) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3192427..3193066) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3192428..3192431 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3192440..3192448) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3192447..3192466 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3192460 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3192474..3192479 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3192495..3192514 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3192505 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3192537..3193058 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3192537..3193058 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3193001..3193004 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3193019..3193038 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3193033 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3193056..3193075) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3193066) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3193077 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3193090..3193097) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3193140..3194747) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3193140..3194747) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3193153) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3194748..3194935) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3194923..3194942) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3194935) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3194957..3194964) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3194989..3195510) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3194989..3195510) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3195045) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3195511..3195613) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3195594..3195613) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3195613) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3195615..3195692) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3195629..3195632) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3195693..3196832) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3195693..3196832) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3196829..3198946) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3196829..3198946) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3198947..3199005) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3199006..3199025) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3199019) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3199039..3199046) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3199045..3199051 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3199065..3199076 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3199070 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3199101..3200297 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3199101..3200297 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3199293..3200171) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3200161..3200179) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3200172) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3200195..3200200) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3200310..3201272 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3200310..3201272 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3201286..3201292 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3201307..3201325 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3201307 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3201353..3201625 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3201353..3201625 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3201359) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3201615 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3201660..3202066 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3201667..3202191) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3201667..3202191) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3201689) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3202201..3203928) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3202201..3203928) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3203962..3203981) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3203976) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3203995..3204001) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3204017..3205519) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3204017..3205519) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3205543..3205561) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3205561) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3205576..3205582) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3205606..3205978) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3205649) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3206005..3206676) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3206005..3206676) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3206023) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3206673..3207227) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3206673..3207227) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3207253..3208716) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3207253..3208716) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3208706..3212392) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3208706..3212392) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3212423..3212442) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3212447) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3212449..3212578) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3212588..3213064) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3212588..3213064) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3212623) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3213087..3213106) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3213099) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3213121..3213124) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3213171 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3213174..3213193 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3213208..3213927 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3213208..3213927 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3213911 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3213959..3214675) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3213959..3214675) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3213961) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3214031) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3214701..3214720) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3214713) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3214774..3215961) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3214774..3215961) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3215991..3216010) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3216009) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3216097..3217767) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3216097..3217767) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3216099) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3217764..3218192) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3217764..3218192) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3218260..3218274 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3218260..3218279) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3218267 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3218276) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3218296..3218299) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3218331..3218350) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3218343) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" SCAR join(3218372,3218379) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs09" N_region 3218373..3218378 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs09" S_feature <3218379..3220857 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3218380..3219756) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3218380..3219756) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3219795..3221150) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3219795..3221150) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3221186..3221205) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3221204) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3221218..3221227) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3221330..3221349 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3221331 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3221376) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3221380..3222525 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3221380..3222525 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3222384..3222388 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3222405..3222424 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3222412 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3222495) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3222509..3222628 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3222509..3222628 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3222613 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3222658..3222726 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3222727..3223200 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3222727..3223200 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3223189 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3223232..3224104) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3223232..3224104) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3223243) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3223309) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3224165..3224995) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3224165..3224995) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3224996..3225091) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3225079..3225098) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3225090) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3225111..3225118) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3225136..3225141 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3225157..3225175 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3225159 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3225197..3227272 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3225197..3227272 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3227325) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3227449..3227564) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3227492) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3227565..3228083) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3227565..3228083) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3228097..3228756) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3228097..3228756) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3228779..3228782 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3228792..3228811) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3228797..3228816 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3228800 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3228810) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3228812..3229095) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3228826..3228833) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3228865..3229053 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3228865..3229053 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3229042 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3229096..3229515) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3229096..3229515) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3229565..3229584) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3229576) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3229599..3229606) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3229635..3231551) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3229635..3231551) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3230829..3230847) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3230834) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3230864..3230868) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3231582) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3231605..3231826) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3231605..3231826) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3231858..3232079) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3231858..3232079) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3232111..3232373) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3232122 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3232154) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3232161..3232316) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3232161..3232316) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3232323..3232326 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3232335..3232348 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3232342 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3232350..3232369) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3232373) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3232383..3232389) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3232396..3233796) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3232396..3233796) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3233796..3234266) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3233796..3234266) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3234222) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3234378..3234878) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3234378..3234878) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3234381) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3234914..3236215) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3234914..3236215) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3236239..3236258) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3236253) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3236255..3236376) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3236274..3236276) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3236377..3236601) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3236377..3236601) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3236602..3236686) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3236675..3236694) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3236685) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3236709..3236712) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3236752..3236758 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3236773..3236784 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3236774 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3236816..3237592 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3236816..3237592 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3237578 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3237680..3237687 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3237702..3237721 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3237706..3241932 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3237706 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3237736..3238626) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3237736..3238626) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3238626..3238726) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3238666) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3238794..3239639) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3238794..3239639) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3238957) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3239688..3240587) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3239688..3240587) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3240630..3240649) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3240633) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3240663..3240670) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3240734) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3240734..3241705) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3240734..3241705) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3241740..3241759) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3241765) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3241775..3241779) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3241853..3241864) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3241856) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3241878..3241884) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3241927..3241946 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3241934 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3241975..3242739 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3241975..3242739 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3242726 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(3242746,3242753) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs11" N_region 3242747..3242752 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs11" S_feature <3242753..3242805 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" CDS complement(3242755..3243993) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3242755..3243993) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3244035..3244054) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3244047) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3244066..3244073) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3244203..3245615) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3244203..3245615) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3244210) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3245615..3247315) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3245615..3247315) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3246284..3246300) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3246296) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3247389..3248936) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3247389..3248936) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3247396) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3248980) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3248982..3249162) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3248983..3249001) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3249163..3250437) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3249163..3250437) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3250438..3250520) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3250520) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3250533..3250551) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3250613) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3250614..3251078) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3250614..3251078) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3251079..3251189) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3251171..3251190) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3251189) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3251205..3251212) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3251400) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3251402..3251857) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3251402..3251857) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3251492..3251511 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3251500 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3251850..3252701) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3251850..3252701) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3252715..3253662) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3252715..3253662) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3253662..3254402) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3253662..3254402) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3254420..3254425 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3254426 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3254427..3255446) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3254427..3255446) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3254440..3254458 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3255310..3255319 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3255332..3255347 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3255343 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3255449..3256171) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3255449..3256171) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3256164..3257285) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3256164..3257285) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3257285..3258154) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3257285..3258154) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3258155..3259324) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3258155..3259324) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3259345..3260769) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3259345..3260769) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3260774..3261544) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3260774..3261544) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3261579..3261598) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3261593) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3261612..3261621) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3261712..3261717 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3261733..3261751 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3261735..3261863 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3261735 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3261864..3262409 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3261864..3262409 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3262395 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3262453..3262824) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3262453..3262824) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3262471) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3262886..3264208) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3262886..3264208) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3264228..3264545) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3264228..3264545) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3264574..3264593) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3264585) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3264607..3264613) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3264648..3264655 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3264671..3264690 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3264674 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3264713..3266083 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3264713..3266083 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3266108..3266785) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3266108..3266785) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3266122) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3266612..3266631) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3266628) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3266647..3266652) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3266799..3267605) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3266799..3267605) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3267098..3267116) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3267112) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3267131..3267137) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3267634..3267653) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3267640) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3267669..3267676) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3267695..3268228) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3267695..3268228) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3268276..3268911) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3268276..3268911) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3268904..3269242) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3268904..3269242) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3269264..3269283) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3269275) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3269298..3269305) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3269326..3269329 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3269344..3269363 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3269344 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3269386..3270201 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3269386..3270201 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3270180 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3270256) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3270291..3270539) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3270291..3270539) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3270311) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3270557) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3270559..3270632) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3270567..3270573) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3270633..3272072) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3270633..3272072) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3272069..3273454) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3272069..3273454) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3273473..3273482) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3273487) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3273489..3273553) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3273532..3273549) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3273553) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3273565..3273572) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3273595..3273614) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3273613) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3273628..3273635) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3273694..3273697 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3273704 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3273712..3273731 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3273756..3274526 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3273756..3274526 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3274527..3275594 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3274565..3275395) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3274565..3275395) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3274566) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3275421..3275440) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3275427) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3275435..3275737) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3275435..3275737) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3275455..3275462) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3275738..3275876) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3275861..3275880) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3275876) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3276191..3276199 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3276210..3276228 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3276211 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3276267..3276344 /gene="vpr" /old_locus_tag="BSU_38090" /created_by="User" /modified_by="User" /transl_table=11 /locus_tag="PG10_BSU_38090-3'_ext" /translation="MKKGISQQTPPAISDTIGAYLQNDA*" /label="PG10_BSU_38090-3'_ext" gene 3276267..3276344 /gene="vpr_3'-chimera" /old_locus_tag="BSU_38090" /created_by="User" /locus_tag="PG10_BSU_38090-3'_ext" /label="PG10_BSU_38090-3'_ext" SCAR 3276277..3276278 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_017" CDS complement(3276280..3277281) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3276280..3277281) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3277282..3277443) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3277455..3278204) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3277455..3278204) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3277488) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3278222..3278241) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3278239) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3278256..3278259) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3278310..3279491) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3278310..3279491) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3278324) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3279492..3279623) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3279617..3279632) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3279623) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3279644..3279653) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3279858..3279865 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3279876..3279986 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3279876..3279895 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3279876 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3279987..3280250 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3279987..3280250 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3280140 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3280256 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3280293..3280667) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3280293..3280667) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3280304) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3280669..3281283) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3280669..3281283) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3281297..3283246) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3281297..3283246) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3282510..3282529 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3282516 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3282940..3283040 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3283000 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3283110 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3283274..3284239) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3283274..3284239) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3284240..3284308) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3284295..3284314) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3284308) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3284310..3284495) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3284327..3284331) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3284426..3284431 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3284447..3284465 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3284452 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3284486..3284505) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3284495) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3284497..3284606) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3284520..3284524) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3284562 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3284591..3284610) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3284606) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3284626..3284630) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3284684..3284702) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3284689..3284695 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3284701) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3284710..3284728 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3284713 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3284718..3284723) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3284755..3285000 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3284755..3285000 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3284982 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3285071..3286612) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3285071..3286612) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3285100) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3286616..3287788) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3286616..3287788) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3287806..3287824) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3287828) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3287839..3287845) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3287869..3288252) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3287869..3288252) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3288270..3288941) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3288270..3288941) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3288963..3288982) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3288972) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3288998..3289001) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3289082..3289085 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3289100..3289119 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3289109..3289296 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3289109 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3289297..3289455 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3289297..3289455 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3289456..3289840 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3289821..3289826 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3289842..3289860 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3289842 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3289898..3290206 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3289898..3290206 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3289984) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3289988..3290088) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3290028) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3290203..3291744 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3290203..3291744 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3291735 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3291775..3292377) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3291775..3292377) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3291789) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3292378..3292659) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3292660..3293910) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3292660..3293910) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3292756) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3293929..3295086) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3293929..3295086) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3294002..3294021) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3294029) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3295083..3296528) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3295083..3296528) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3296562..3296581) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3296572) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3296595..3296602) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3296685..3297353) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3296685..3297353) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3296694) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3297350..3298168) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3297350..3298168) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3298176..3299081) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3298176..3299081) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3298816..3298835) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3298827) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3299122..3299141) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3299132..3299139 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3299143) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3299151 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3299153..3299172 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3299157..3299164) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3299187..3299573 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3299187..3299573 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3299555..3300232 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3299555..3300232 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3300204 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3300276..3300283 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3300294 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3300297..3300316 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3300336..3301535 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3300336..3301535 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3301569..3301766 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3301569..3301766 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3301745 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3301801..3302991) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3301801..3302991) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3301816) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3301900) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3303015..3303034) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3303031) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3303051..3303058 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3303067 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3303072..3303091 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3303112..3303492 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3303112..3303492 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3303390 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3303461 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" downshifts complement(3303537) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 3303552..3303553 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_020" promotor_-35 <3303553..3303556 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3303571..3303590 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3303590 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3303802..3303809 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3303822..3303841 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3303822 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3303874..3305253 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3303874..3305253 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3304962..3306165) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3305307..3306149 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3305307..3306149 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3306200..3307060) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3306200..3307060) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3306210) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3307044 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3307082..3307100) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3307100) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3307115..3307121) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3307170..3307883) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3307170..3307883) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3307285..3307286 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3307306..3307323 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3307308 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3307911..3307922) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3307912) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3307937..3307943) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3307958..3307964 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3307979..3307998 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3307989 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3308034..3308549 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3308034..3308549 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3308550..3308756 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3308550..3308756 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3308716 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3308798..3310039 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3308798..3310039 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3310130..3310138 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3310149..3310167 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3310160 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3310195..3311562 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3310195..3311562 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3311539 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3311592..3312224) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3311592..3312224) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3311610) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3312260..3312275) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3312268) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3312288..3312296) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3312366..3313301) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3312366..3313301) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3312378) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3313045..3313054 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3313068..3313087 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3313072 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3313302..3313389) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3313372..3313391) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3313389) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3313407..3313411) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3313434..3313446) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3313434) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3313461..3313467) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3313464..3313598) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3313464..3313598) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3313545..3313552 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3313566..3313585 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3313575 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3313578..3313682 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3313677..3313686 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3313684 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3313698..3313713 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3313720) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3313722..3313736) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3313748..3313897 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3313748..3313897 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3313915..3315426 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3313915..3315426 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3315423..3316610 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3315423..3316610 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3316627..3316863 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3316627..3316863 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3316863..3318041 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3316863..3318041 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3318042..3318131 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3318132..3318890 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3318132..3318890 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3318858 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3318892..3320119) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3318938..3318945 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3318959..3318978 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3318972 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3319031..3320122 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3319031..3320122 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3320024 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3320112 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3320156..3321484) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3320156..3321484) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3320164) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3321481..3321813) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3321481..3321813) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3321832..3323190) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3321832..3323190) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3323206..3323514) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3323206..3323514) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3323559..3323578) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3323575) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3323592..3323598) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3323643) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3323643..3325568) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3323643..3325568) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3324306..3324315 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3324329..3324348 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3324337 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3325641..3325658) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3325665) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3325673..3325680) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3325731..3325889) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3325731..3325889) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3325758) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3325918..3326508) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3325918..3326508) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3326536..3326554) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3326547) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3326568..3326574) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3326577..3326583 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3326599..3326617 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3326602 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3326637..3328280 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3326637..3328280 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3326774..3328323) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3328275 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3328325..3328416) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3328327..3328333 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3328341 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3328348..3328367 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3328368) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3328385..3329587 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3328385..3329587 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3328418..3329583) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3328461) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3329584..3330360) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3329584..3330360) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3330357..3331244) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3330357..3331244) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3331251..3331439) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3331251..3331439) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3331436..3331642) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3331436..3331642) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3331639..3331959) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3331639..3331959) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3331772..3331781 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3331794..3331813 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3331796 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3331952..3332488) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3331952..3332488) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3332516) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3332517..3332532) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3332544..3332553) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3332619..3332626 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3332640..3332659 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3332649 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3332700..3334073 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3332700..3334073 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3332980..3333522) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3333510..3333529) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3333522) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3333544..3333551) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3333908 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3334088..3334918) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3334088..3334918) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3334094) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3334937..3334955) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3334952) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3334970..3334976) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3334996) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3334998..3335017) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3335004..3336731) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3335004..3336731) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3335103) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3336728..3338431) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3336728..3338431) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3338431..3339447) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3338431..3339447) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3339321..3339339) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3339330) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3339355..3339360) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3339431..3340837) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3339431..3340837) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3340838..3341046) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3341029..3341048) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3341046) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3341048..3341156) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3341062..3341067) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3341153..3341172) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3341168) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3341186..3341193) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3341314..3341321 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3341331 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3341336..3341354 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3341393..3342745 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3341393..3342745 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3342344..3344826) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3342730 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3342821..3342840 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3342827 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3342867..3344555 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3342867..3344555 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3344553..3344562 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3344574..3344589 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3344578 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3344613..3344813 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3344613..3344813 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3344814..3345758 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3344827..3345666) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3344827..3345666) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3345692..3345710) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3345710) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3345723..3345730) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3345725 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3345773..3346870) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3345773..3346870) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3345774) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3346903..3346922) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3346920) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3346922..3346990) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3346935..3346942) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3346991..3347884) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3346991..3347884) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3347911..3347930) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3347930) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3347944..3347951) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3347958..3347963 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3347979..3347997 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3347988 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3348005..3348011 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3348026..3348044 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3348032 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3348068..3349525 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3348068..3349525 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3348951..3348969) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3348966) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3348984..3348989) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3349506 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3349550 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3349567..3350403) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3349567..3350403) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3349585) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3350480..3350582) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3350480..3350582) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3350506) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3350608..3350627) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3350619) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3350621..3351362) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3350641..3350647) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3350699..3350706 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3350719..3350737 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3350728 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3350738..3350823 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3350799..3350806 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3350820..3350839 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3350825 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3350971..3351513 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3350971..3351513 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3351338..3351357) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3351362) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3351371..3351380) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3351503 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3351548..3351870 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3351588..3352607) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3351588..3352607) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3351606) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3352633..3352652) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3352647) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3352667..3352670) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3352722..3353228) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3352722..3353228) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3353234..3353253) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3353256) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3353258..3353261 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3353267..3353273) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3353276..3353295 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3353279 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3353358..3354233 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3353358..3354233 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3353608..3353696) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3353630) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3353656..3353756) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3353696) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3354311..3354784 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3354311..3354784 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3354802..3356022 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3354802..3356022 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3356009..3356665 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3356009..3356665 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3356663..3356668 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3356682..3356701 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3356685 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3356715..3357947 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3356715..3357947 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3356732) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3357932 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3357993..3358002 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3358015..3358030 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3358017..3358239 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3358017 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3358196 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3358250..3358256 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3358269..3358369 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3358269 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3358271..3358289 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3358348..3358355 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3358369..3358387 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3358371..3358468 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3358371 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3358469..3358732 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3358469..3358732 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3358496..3358499 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3358514..3358533 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3358526 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3358680 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3358724 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3358799..3358808 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3358814 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3358820..3358835 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3358861..3359349 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3358861..3359349 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3359354..3359361 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3359375..3359394 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3359385 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3359415..3359521 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3359415..3359521 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3359516 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3359604..3360737 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3359604..3360737 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3359877..3360120) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3360115..3360134) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3360124) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3360149..3360156) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3360743..3360750 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3360765..3360784 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3360771 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3360806..3360912 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3360806..3360912 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3360859 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3360913..3360989 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3360990..3362126 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3360990..3362126 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3362113 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3362179..3362952) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3362179..3362952) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3362189) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3362969..3363619) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3362969..3363619) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3363616..3364332) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3363616..3364332) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3364356..3365774) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3364356..3365774) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3364942..3364960) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3364961) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3364976..3364981) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3365775..3365859) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3365843..3365861) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3365859) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3365877..3365882) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3365928..3366776) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3365928..3366776) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3365938) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3366777..3366962) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3366951..3366970) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3366962) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3366964..3367689) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3366986..3366990) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3367124..3367131 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3367144..3367163 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3367153 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3367163..3367265 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3367163..3367265 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3367266..3367369 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3367341..3367347 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3367361..3367372 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3367371 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3367392..3368585 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3367392..3368585 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3367676..3367694) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3367692) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3367707..3367714) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3368361 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3368581 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3368627..3369055) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3368627..3369055) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3369056..3369298) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3369056..3369298) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3369299..3369362) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3369351..3369366) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3369362) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3369378..3369387) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3369395 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3369443..3369733) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3369443..3369733) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3369449) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3369758..3369777) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3369775) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3369783..3371843) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3369783..3371843) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3369791..3369798) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3371872..3371890) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3371876) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3371905..3371911) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3371936..3371941 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3371955 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3371957..3371975 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3371969..3372043 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3372044..3373324 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3372044..3373324 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3373325..3373464 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3373421 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3373482..3374210) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3373482..3374210) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3373499) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3374241..3374260) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3374252) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3374274..3374281) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3374398..3374505) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3374441) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3374506..3375339) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3374506..3375339) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3375370..3375389) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3375389) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3375403..3375410) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3375435..3376115) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3375435..3376115) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3376162..3376181) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3376171) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3376195..3376202) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3376263..3376266 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3376281..3376300 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3376281 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3376322..3377608 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3376322..3377608 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3377053..3377071) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3377061) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3377085..3377092) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3377579 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3377627..3379066) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3377627..3379066) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3377650) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3379090..3379109) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3379107) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3379148..3380296) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3379148..3380296) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3380323..3380339) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3380339) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3380341..3380425) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3380354..3380359) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3380426..3380614) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3380426..3380614) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3380645..3380776) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3380645..3380776) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3380788..3381249) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3380788..3381249) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3381265..3381561) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3381265..3381561) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3381589..3382077) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3381589..3382077) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3382095..3382547) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3382095..3382547) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3382548..3382616) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3382617..3382946) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3382617..3382946) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3382947..3383068) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3383069..3383485) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3383069..3383485) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3383536..3383904) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3383536..3383904) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3383898..3384368) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3383898..3384368) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3384369..3384693) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3384694..3385122) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3384694..3385122) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3385184..3392188) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3385184..3392188) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3392195..3392209 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3392209 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3392219..3392238) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3392234) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3392253..3392260) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3392350..3393285) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3392350..3393285) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3392571) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3393286..3393406) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3393437..3393883) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3393437..3393883) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3393451) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3393920..3393939) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3393927) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3393953..3393960) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3393986..3395395) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3393986..3395395) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3395418..3397247) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3395418..3397247) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3397239..3397339) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3397279) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3397281..3397473) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3397454..3397473) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3397473) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3397475..3397608) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3397486..3397493) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3397630..3397938) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3397630..3397938) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3397653) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3397984..3398427) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3397984..3398427) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3398424..3400133) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3398424..3400133) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3399295..3399314) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3399303) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3400153..3400422) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3400153..3400422) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3400434..3400799) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3400434..3400799) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3400800..3400865) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3400852..3400871) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3400865) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3400886..3400889) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3401106..3402515) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3401106..3402515) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3401129) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3402516..3402625) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3402649..3402813) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3402649..3402813) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3402698..3402716) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3402713) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3402727..3402735) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3403005..3403024) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3403021) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3403037..3403044) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3403053..3403060 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3403075..3403094 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3403078 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3403132..3403578 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3403132..3403578 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3403583 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3403691..3405217 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3403691..3405217 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3405214..3406872 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3405214..3406872 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3406885..3408150 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3406885..3408150 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3408143..3409102 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3408143..3409102 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3409103..3409177 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3409178..3410605 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3409178..3410605 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3410601 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3410649..3411950) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3410649..3411950) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3410666) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3411980..3413161) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3411980..3413161) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3413162..3413241) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3413242..3413913) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3413242..3413913) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3413862..3413865 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3413880 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3413881..3413900 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3413941..3413960) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3413956) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3413974..3413981) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3414019..3414960) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3414019..3414960) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3415005..3415024) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3415011) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3415013..3415093) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3415040..3415043) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 3415109..3415110 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_018" promotor_-35 3415206..3415212 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3415228..3415246 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3415238 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3415300..3416685 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3415300..3416685 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3416671 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3416716..3417266 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3416727..3418607) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3416727..3418607) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3416733) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3418608..3418705) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3418696..3418715) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3418705) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3418730..3418737) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3418775..3419026) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3418775..3419026) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3418793) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3419048..3419067) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3419057) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3419090..3419096 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3419110..3419128 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3419111 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3419143..3419964 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3419143..3419964 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3419948 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3419993..3421135) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3419993..3421135) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3420003) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3421136..3421235) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3421223..3421242) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3421234) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3421256..3421263) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3421278..3422615 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3421278..3422615 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3422020..3422620) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3422654..3423133) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3422654..3423133) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3422665) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3423213..3424205) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3423213..3424205) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3423237) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3424195 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3424228..3424247) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3424246) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3424262..3424269) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3424268..3424275 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3424289..3424713 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3424289 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3424290..3424309 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3424295..3424707 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3424295..3424707 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3424315) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3424325..3424339) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3424347..3424351) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3424679 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3424714..3425448 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3424714..3425448 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3425448..3425717 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3425448..3425717 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3425721..3426203 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3425721..3426203 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3426224..3428467 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3426224..3428467 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3428464..3429663 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3428464..3429663 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3429419..3429437) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3429441) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3429452..3429458) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3429654 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3429727) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3429727..3430959) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3429727..3430959) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3430991..3431010) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3431003) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3431024..3431029) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3431060..3431485) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3431060..3431485) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3431513..3431532) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3431527) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3431545..3431551) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3431677..3431684 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3431694 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3431699..3431718 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3431742..3432197 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3431742..3432197 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3432135 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3432198..3432811 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3432227..3433435) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3432227..3433435) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3432254) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3433436..3433542) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3433543..3434556) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3433543..3434556) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3434557..3434630) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3434615..3434634) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3434630) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3434647..3434654) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3434650..3435225) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3434650..3435225) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3434674) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3435254..3435273) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3435268) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3435288..3435295) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3435296..3435302 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3435317..3435335 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3435324 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3435356..3436426 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3435356..3436426 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3436424 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3436483..3436914) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3436483..3436914) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3436944..3436951 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3436965..3436984 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3436974..3437140 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3436974 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3437026..3437045) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3437046) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3437060..3437067) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3437141..3437545 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3437141..3437545 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3437162..3438214) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3437515..3438207 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3437515..3438207 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3438247..3439278) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3438247..3439278) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3438259) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3439245..3439248 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3439261 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3439265..3439284 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3439315..3439333) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3439333) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3439348..3439354) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3439371..3440519) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3439371..3440519) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3440558..3440577) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3440569) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3440588..3440595) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3440641..3440648 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3440662..3440681 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3440669 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3440715..3441446 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3440715..3441446 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3441439..3442980 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3441439..3442980 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3443009..3444355 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3443009..3444355 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3443808..3443812 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3443828..3443847 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3443837 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3444378..3445784 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3444378..3445784 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3445773 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3445881..3445900 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3445883..3446174 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3445883 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3446147..3446154 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3446169..3446188 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3446176 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3446198..3446205 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3446220..3446239 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3446223) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3446226..3446240) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3446235 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3446248..3446252) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3446248..3446811 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3446248..3446811 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3446825..3448354 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3446825..3448354 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3448181) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3448347 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3448380..3448463) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3448423) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3448464..3449903) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3448464..3449903) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3449917..3450147) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3449917..3450147) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3450148..3450359) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3450356..3450375) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3450361) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3450390..3450397) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3450423..3450430 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3450441..3450460 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3450456 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3450491..3451201 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3450491..3451201 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3451229..3451387 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3451229..3451387 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3451464 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3451518..3452240) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3451518..3452240) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3451530) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3452141..3452144 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3452160..3452164 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3452175 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3452261..3452890) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3452261..3452890) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3452891..3453039) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3453040..3453798) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3453040..3453798) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3453488..3453507) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3453504) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3453520..3453527) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3453779..3454738) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3453779..3454738) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3454727 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3454774..3454777 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3454782 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3454796..3454945) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3454796..3454945) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3454803) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3454854..3454871 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3454859 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3454940 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3454966..3454985) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3454987) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3455000..3455007) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3455280..3455287 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3455302..3455321 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3455306 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3455417..3457342 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3455417..3457342 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3457343..3458707 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3457555..3457875) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3457876..3459636) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" /label="yydD CDS" gene complement(3457876..3459636) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /label="yydD gene" downshifts complement(3457919) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" /label="downshifts" misc_feature 3458704..3458705 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3458709 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3459636..3460034) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" /label="yydC CDS" gene complement(3459636..3460034) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /label="yydC gene" CDS complement(3460027..3461472) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" /label="yydB CDS" gene complement(3460027..3461472) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /label="yydB gene" promotor_-35 3460722..3460729 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3460741..3460760 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3460751..3461800 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3460751 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3461473..3461733) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3461734..3462213) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " /label="rlmH CDS" gene complement(3461734..3462213) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /label="rlmH gene" S_feature complement(3462214..3462293) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3462294..3462464) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" /label="yyzF CDS" gene complement(3462294..3462464) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /label="yyzF gene" promotor_-10 complement(3462505..3462524) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3462521) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3462538..3462543) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3462587..3462594 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3462607..3462626 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3462624 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="upshifts" CDS 3462649..3463062 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" /label="yycS CDS" gene 3462649..3463062 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /label="yycS gene" downshifts 3463042 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3463096..3464322) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" /label="yycR CDS" gene complement(3463096..3464322) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /label="yycR gene" downshifts complement(3463111) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3464345..3464363) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3464350) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3464375..3464383) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3464385..3464555) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" /label="yyzG CDS" gene complement(3464385..3464555) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /label="yyzG gene" promotor_-10 complement(3464574..3464592) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3464592) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3464606..3464612) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3464660..3464908) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" /label="yycQ CDS" gene complement(3464660..3464908) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /label="yycQ gene" CDS complement(3464924..3466087) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" /label="yycP CDS" gene complement(3464924..3466087) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /label="yycP gene" promotor_-10 complement(3464958..3464976) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3464966) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3464988..3464996) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3466098..3466835) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" /label="yycO CDS" gene complement(3466098..3466835) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /label="yycO gene" promotor_-10 complement(3466877..3466895) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3466883) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3466909..3466917) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3466977..3467447) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" /label="yycN CDS" gene complement(3466977..3467447) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /label="yycN gene" downshifts complement(3466990) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3467448..3467518) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3467479..3467485 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3467499..3467518 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3467500..3467519) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3467500 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3467518) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3467520..3467795) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3467534..3467541) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3467558..3468655 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" /label="rapG CDS" gene 3467558..3468655 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /label="rapG gene" promotor_-10 complement(3467786..3467804) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3467795) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="upshifts" promotor_-35 complement(3467819..3467824) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3468379..3468387 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3468399..3468417 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3468412 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="upshifts" CDS 3468656..3468772 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" /label="phrG CDS" gene 3468656..3468772 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /label="phrG gene" downshifts 3468761 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3469009..3469899) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3469009..3469899) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3469015) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3469077) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3469973..3471376) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3469973..3471376) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3471377..3471598) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3471599..3472804) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3471599..3472804) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3472861..3472879) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3472864) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3472974..3472979 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3472994..3473013 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3473009 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3473045..3474430 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3473045..3474430 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3474412..3474600) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3474412..3474600) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3474717..3474845) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3474717..3474845) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3474769 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3474865..3476067) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3474865..3476067) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3474889) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3476099..3476110) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3476099) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3476125..3476131) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3476149..3476943) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3476149..3476943) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3476965..3477807) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3476965..3477807) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3477794..3479161) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3477794..3479161) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3478388,3478390) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3479151..3480986) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3479151..3480986) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3480994..3481701) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3480994..3481701) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3481702..3481798) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3481786..3481805) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3481798) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3481800..3481992) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3481821..3481824) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3481992) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3482002..3482021) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3482084) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3482085..3482157) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3482085..3482157) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3482193..3482269) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3482193..3482269) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3482270..3482350) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3482351..3482422) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3482351..3482422) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3482432..3482507) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3482432..3482507) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3482479..3482495 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3482492 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3482508..3482604) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3482588..3482607) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3482604) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3482621..3482628) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3482638..3482739) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3482678) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3482732..3484024) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3482732..3484024) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3482743) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3484064..3484083) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3484084) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3484098..3484105) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3484230..3484649) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3484230..3484649) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3484647..3484658) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3484658) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3484673..3484679) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3484770..3486134) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3484770..3486134) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3484790) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3484834) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3486165..3486184) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3486179) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3486199..3486201) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3486246..3486252 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3486267..3486285 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3486269 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3486304..3486504 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3486304..3486504 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3486474 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3486519..3486840 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3486552..3486755) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3486552..3486755) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3486756..3487056) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3486821..3486824 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3486839..3486858 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3486842 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3486876..3487016 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3486876..3487016 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3487017..3487088 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3487064) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3487067..3487081) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3487089..3487093) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3487089..3488297 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3487089..3488297 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3488278 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3488402..3490459 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3488402..3490459 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3490324 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3490496..3490945) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3490496..3490945) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3490510) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3490942..3492921) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3490942..3492921) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3491423..3491442) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3491426) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3491839..3491846 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3491860..3491878 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3491864..3492530 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3491864 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3492958..3493887) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3492958..3493887) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3493888..3494024) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3494006..3494025) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3494024) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3494040..3494045) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3494114..3494263) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3494114..3494263) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3494140) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3494302..3494321) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3494319) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3494335..3494341) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3494342..3494351 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3494364..3494383 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3494370 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3494382) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3494384..3494897) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3494386..3494400) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3494409..3494413) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3494409..3494891 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3494409..3494891 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3494878 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3494921..3495298) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3494921..3495298) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3494923..3495452 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3494942) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3495353..3495372) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3495365) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3495386..3495393) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3495434..3495438 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3495452..3495471 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3495454 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3495479..3495493) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3495482) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3495503..3496432 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3495503..3496432 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3496418 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 3496434..3496435 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_014" CDS complement(3496437..3496991) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3496437..3496991) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3497009..3497389) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3497009..3497389) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3497445..3498380) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3497445..3498380) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3498370..3498379 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3498393..3498412 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3498400 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3498424..3498443) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3498438) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3498439..3499197) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3498439..3499197) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3498456..3498463) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3498730..3499233 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3499192 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3499262..3499501) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3499262..3499501) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3499268) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3499336) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3499545..3500063) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3499545..3500063) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3500104..3500391) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3500104..3500391) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3500392..3500458) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3500457..3500476) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3500458) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3500490..3500495) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3500502..3501602) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3500502..3501602) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3501650..3501669) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3501665) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3501684..3501691) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3501729..3503732) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3501729..3503732) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3503783..3503989) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3503783..3503989) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3503951..3503970) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3503976) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3503985..3503991) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3504015..3504034) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3504026) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3504051..3504055) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3504083..3505099) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3504083..3505099) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3505132..3505150) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3505144) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3505166..3505171) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3505275) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3505459..3505464 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3505477..3505558 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3505477 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3505480..3505498 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3505559..3506176 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3505559..3506176 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3506147..3506155 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3506166 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3506169..3506187 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3506188 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3506215..3507063) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3506215..3507063) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3506235) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3507056..3507817) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3507056..3507817) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3507851..3507870) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3507869) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3507961) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3507964..3507972) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3507986..3507994) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3507998..3508006 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3508014 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3508018..3508036 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3508065..3508505 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3508065..3508505 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3508454 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3508556..3509407) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3508556..3509407) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3508575) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3509408..3509528) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3509529..3510248) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3509529..3510248) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3510262..3512148) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3510262..3512148) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3512169..3513548) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3512169..3513548) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3513549..3513679) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3513671..3513690) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3513679) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3513706..3513710) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3513734..3513753) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3513744) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3513767..3513774) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3513834..3513840 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3513845..3516130 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3513845 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3513855..3513874 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3513859..3514485) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3513859..3514485) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3513876) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3514482..3515267) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3514482..3515267) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3515312..3515331) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3515324) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3515326..3515411) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3515343..3515349) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3515412..3515762) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3515412..3515762) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3515763..3515913) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3515914..3516048) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3515914..3516048) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3516072..3516172 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3516084..3516103) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3516094) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3516096..3516164) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3516119..3516126) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3516132..>3516265 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3516132 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3516150..3516169) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3516164) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3516185..3516189) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3516266..3516413 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3516289..3516562) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3516415..3516674 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcatgggaca aggcctgttt ttttctttct ccgtaaaagt tttatcataa 226681 gaatcagaaa cctgattata atgtaaaagt cttccatcga tacgggtggt tgacactaaa 226741 ggagggagat gacaaaatga aattagttcc aagattcaga aaacaatggt tcgcttactt 226801 aacggttttg tgtttggctt tggcagcagc ggtttctttt ggcgtaccgg caaaagcggc 226861 agagaacccg caaacttctg tatcgaatac cggtaaagaa gctgatgcta cgaaaaacca 226921 aacgtcaaaa gcagatcagg tttccgcccc ttatgaggga accggaaaaa caagtaaatc 226981 gttatacggc ggccaaacgg aactggaaaa aaacattcaa accttacagc cttcgagcat 227041 tatcggaact gatgaacgca ccagaatctc cagcacgaca tcttttccat atagagcaac 227101 cgttcaactg tcaatcaagt atcccaacac ttcaagcact tatggatgta ccggattttt 227161 agtcaatcca aatacagtcg tcacggctgg acattgtgtg tacagccagg atcatggatg 227221 ggcttcgacg ataaccgccg cgccgggccg caatggttcg tcatatccgt acggtactta 227281 ttcaggcacg atgttttact ccgtcaaagg atggacggaa agcaaagaca ccaactatga 227341 ttacggagct attaaattaa acggttctcc tggaaacacg gttggctggt acggctaccg 227401 gactacaaac agcagcagtc ccgtgggcct ttcctcgtca gtgacaggat tcccatgtga 227461 caaaaccttt ggcacgatgt ggtctgatac aaagccgatt cgctccgctg aaacgtataa 227521 gctgacctat acaaccgata cgtacggctg ccaaagcggc tcgcctgttt atcgaaacta 227581 cagtgataca gggcagacag ctattgccat tcacacgaac ggaggatcgt catataactt 227641 gggaacaagg gtgacgaacg atgtattcaa caatattcaa tattgggcaa atcaataaat 227701 acagcaaact agccatattc atgtctattt tgtttttatg cgggtgcagt tcgcagacgc 227761 attcttctca aaaagaaacg actattcctg tcactcttca tgtggaggat gctaaggggc 227821 tgccggtcga aggggttcaa gtgacgattg tcaaagcgcc ctcttcagat gaggagccga 227881 gtacagagat tggcgagata ctcggtaaaa cagacaaaaa cggagatatc aaatgggata 227941 ccggcagaaa aggcgattac tcagtcgcgt tgacgaaggg tgaaacatca gtaacccatc 228001 acatctcgtt aacagaggat aaaaaagatc atgccattcc attagtcttc aaagaatagc 228061 agtttccttg attttaaggg aactgccttt tttatttatt gcaggaaacc aaactatata 228121 ctggaaattt attatgtgag ataataagaa ataggtattt tttcttacga gacaaaaggg 228181 gcgttatcct ttatatcaat caaacccgga ggaaaaagaa gaagatgata caagattcaa 228241 tgcagtttgc cgcggttgaa agtggtctgc gcttttacca ggcatatgat caaagccttt 228301 ctttgtggcc gattgagtcg gaagcattct atgtttctac tcgttttgga aaaacacata 228361 tcattgcaag tgggccaaag gacgcacctt cgctcatttt gcttcacgga ggccttttca 228421 gctctgcgat gtggtatccg aatatcgcag cgtggagcag tcaatttcgt acatatgcgg 228481 tcgatataat aggagacaaa aataaaagta taccatcagc agccatggaa acgagagctg 228541 attttgcaga atggatgaaa gatgtctttg attctcttgg acttgagacg gcacatctgg 228601 ccggcctttc gcttggcggg tcccatatcg tgaatttctt actccgcgcg cctgaaagag 228661 tagagcgggc ggttgttatc agtcccgctg aagcgtttat ttcatttcat ccggatgtct 228721 ataaatacgc tgcagagctt acaggggcaa gaggagctga atcatatatc aagtggatca 228781 caggcgacag ttatgatctg catcctttac tgcaaagaca aattgtggcg ggcgtggaat 228841 ggcaggatga gcaaaggagc ctgaagccga cagaaaacgg ctttccgtac gtgttcacag 228901 accaggaatt gaaatcaata caagtcccgg tacttctgat gttcggtgag cacgaggcta 228961 tgtaccatca gcaaatggcc tttgagcggg cttcggtatt ggtgccggga attcaggctg 229021 aaatcgtaaa gaacgccgga catctgttat ctctggagca gccagagtac gtcaatcaac 229081 gcgtcttgtc ctttttatgc ggggggataa aatagtaagg aacatgaaaa gattggcatt 229141 catttttcaa aaggtaacaa atgttgtata ataatagaat ttgaatgctg ctttttttgg 229201 gagcattcta tgttatcatg cttattggag aaaaattttt cctgtaacgc tattcgatca 229261 ctatcgtcaa ataatataga tggttttaca attggaggtt tggttacact gtgaattaca 229321 tcccctgtat gattacgata ggaaacttca tttgcggatt gctggcgatt cattccttgc 229381 tatatcacaa cattcattca gcagtgcttt ttatttttac aggcatgttc cttgatttct 229441 ttgacgggat ggctgctcgt aagctgaatg ccgtttctga tatggggaga gaactggatt 229501 cgtttgccga tctggttacg tttggggtgg ctccttctat gcttgcttac agtgtcgcgt 229561 tgtataccct gccatttatc gggatcttat gcgcattgac gtacagcatt tgcggaatgc 229621 ttcgcctctc taaatttaac attgaacaaa gcaagctccc gacgtttatc ggtatgccga 229681 ttccgtttgc gggcatgtgt ctcgttattc taagcttcac ctataacccg atccttctgg 229741 caatcggcac ttgcggactc tcatatttga tggtgagtaa aataaaattc cctcatttta 229801 aaaaacatgc ggcagaaaac ctggagtctg ggagatggaa ttagttcagc agctcatagc 229861 ggattacggt tatctcgcta tttttttgat gctggtatta ggaattgtag gattgccgat 229921 tccagatgaa gtgatgatga ccgttgttgg ctatttcacg cataccgatg tattgaatta 229981 tgagctttcg atattgatta gttttgtcgg ggctttgtta ggtatgctga tcagctacat 230041 gattggcaga aaagccggac gcccgtttat cgacaagtac ggcaagtggg tcggcttaaa 230101 agaaaaaaga atgatgaaag tggaaaaatg gatgaagaaa tacggtccat attctcttat 230161 tttaggttat tttattcccg gcgtcagaca tgtgacgtgc tacttttcgg ggatcggcaa 230221 aatggatctg aaaacgtatg ttgcgtttgc tgcaatcggc gcctttttat ggtgctttgt 230281 ttttattaca atcggaaggg ttatagggat tattcatgtt taatacggct gtaaagattc 230341 tgtatcgatc attgatagag ctgacgaatc atcgtctgtc atcctatctg attaaaggat 230401 tttgcgagtc gaaaatcagc aaaccggtca ttccgctttt ctcaaaacat tttcggctga 230461 attgggatga tgtggacggt acggctgctg attacggatc gctgtccgaa ttgttcattc 230521 gacaaataaa tctggagcgg cgccctgtgt caaaagaggc gcatgcggtg gtcagccctg 230581 ttgacggtgt ggttcagacg gtaggaatca tcaacccgaa tcaaaccttt acggtgaagg 230641 gaaaagatta ctcattcgct gagctgaccg gctgtaaaag cgcagaccat caatacaacg 230701 gcggatattt cgtcgtgctg tatttaagcc cgaggcatta tcaccgtttc cattctccga 230761 tcagctgcag gtatcaaaag ctggccgagc tcggaaatcg ctcatacccg gtaaatcaac 230821 taggcttaaa atacgggaaa gatgtgctgt cgaaaaatta tcggtttgtg tacgagctga 230881 atagcggcag ccgaaatgtc ctgatgattc ctgtcggcgc gatgaatatt aattctatcg 230941 tgcagacgaa tacccgtact gaattggaga tcggcgagga gctgggatac ttttcatttg 231001 gctcaaccgt cattttggtt tttgaaaaag acgcgttcca gccgtccgcc catttagcag 231061 aaggccaaga agtccaagtc ggagaactga taggttacga agaataaaaa gaggagcttg 231121 cataaacgca gcgcctcttt ttttgaagaa aggtgagatt catggagaaa caaatcatca 231181 gctggattac agattatcag aacaccggag atgaagccgt cctgcggcaa gtgcgagaag 231241 tgtgctggcc gatcgttgaa gcggttttgc aagagaaagt aatggatgat gaacaagcga 231301 acaatttgcg cgaaaaagga atcgagcggt ttccattcat catcagcaaa taccaagcgg 231361 atgtgcagct tccggttgag acatttttac aaaatacgta tcggttttac tttcatcagg 231421 tgatgagaga atccagctaa agcttctttc aacagagaag cttttttttg ttggcaggaa 231481 aaggaaactt tttctatatc tatctcgtaa tgactagaga acctagcaga aaaggagaga 231541 tagaattgaa acgaatgata gtgagaatga ccctgccgct gctgatcgtt tgtctggcgt 231601 tttcttcttt ttcagcctca gcccgtgctg cttctgaaga aaaatattgg gatcactgga 231661 ttgaacgaca tgcacagcct ctggatgctt ccaatgcttc aaacaaagac cttcgatttc 231721 taaaaaaggt gctgaaggga aaacgaatcg ttcagttagg agaaaccaca cacggtgctg 231781 gcgaaatcaa tgccacaaag gtcagaatga tcaaatacct ccacgaagag ctgggatacg 231841 atgtattggc ctttgaatcc ggctttcctg atacaaatgc atcctacctt aatatggacc 231901 aattaacccc taaaagcacg atgaaaaact ccatttacgc tgtatggcac acagaagatg 231961 tcgtcgaatt gtttgattac atgaaagagc aaaaagagaa aggcgatccg ctgatcctta 232021 ccggttttga tattcaaagc atgaagaatt cattcaatgt agctgcgact caatgggtaa 232081 aagcggtgga ccctgagaaa gcagagttgc tctcccaatc agaaaatgat ttttcaacat 232141 tagtgacaga cagcaatacg tttgatgaat tttcgcaaaa gaaggaaaag cttgtgaaaa 232201 actatcagaa gctgatcaag ttcactaaaa cacatgcttc agagctaaaa gaaaaccttc 232261 caaaagagcc gaaagcttat gagatgttta tgcattctct tcagctgaga attgacgtaa 232321 tggaaacata tatgctggaa gaaatgaaag aaaaactaga ggagtatccg gagaatattg 232381 aggatttttc attctttatg agagaccgca tgatggctga acaatttcag tgggtagccg 232441 acacccttta tccgaaaaag aaaatcattg tctggggcca caattaccat ctacgcaaac 232501 agaatacgaa gatgataaag gactgggtac agctaaacgg ccctaacatg ggtgattatt 232561 tgccggagcg gctgaaaaaa caaacatata cgattggcat ttatgcttac tcaggtgcga 232621 gtcttgatag ctccgataat aagactgtta agccggttac aagcccgccg ccgtctggga 232681 gccttgaagc tttgctgaaa gcggcggacc gaccggctgt ttttgttgat tttctccata 232741 caaaaaacaa gaaaggcact tcgtggatgt ataccccgcg gactgcgctc tattgggggt 232801 acatggaaga gcagatgatc ctgaaggaac aatatgacgg tgtcatttgg ctggagcata 232861 tcacgccctc tgtcattatc aagtgagcgg tgtcccctgt ggtaaacagg ggatttttac 232921 atatcgcaaa aataatcaaa acatataatc cgtgatccat tattctaaaa cagaaaggag 232981 attggagcgt gcaatgtatt atgaaaaagc tgtccagaaa acaatcaatt ggattgaatc 233041 acatttacat gagcaaatat caaacgagga tattgttaac gtttcaagct tttcaaaatt 233101 ccattttcat cggatttttc aaaaagaagt cggcatgtcg gttgcttctt atattcggtt 233161 aagacgtctt gcgaatgcgg cggcagcttt gctttataca gatcatcgta ttatcgatat 233221 tgctttgtat tatcagtttg aatctcaaga agcatttacg aggacgttca aaaagatgta 233281 tcacatgccg ccaggagcat accgaacatt tatgaaacgc tttacttcaa aaaaggagga 233341 atcttacatg gagaaaaaaa tgaaaggctg ggtattgagc gggagccatc cgttccaatt 233401 cgaaatgggg attgaccggg aaaatgtaca tcagggaaaa gcttcagggt atttaaagtc 233461 aacgatggtt caggatatcg gtgaatttgc gacgatgatg cagcaattca aagcagatcg 233521 ctatctagga aaaaggcttc gtctatcaag ttttatcaaa acaaaggggg tgcagcattt 233581 tgcctcactt tggatgcggg ttgacagtgc tgctgatgat gttctccaat ttgataatat 233641 gagcaacaga cctattaccg gaacaaccaa ttggaatcat tatgctatcg ttttagatgt 233701 cccagaaaat agcgctgtga tatcttttgg cgttcaatta tctgggccgg gtcaggtgtg 233761 gatggatcat gttgtttttg aagaggtaga tgagagcgtt ccttcaacaa accttgaaat 233821 gccgggagaa cttttagatg aaccggtaaa tttatctttt gaagaggaac tacaaaaata 233881 gttttcagac aactactttt attagtgagt taatggaaaa tactatttgt tattaataaa 233941 cccttgtgct gcttaggttt gtaagagctt ggatattttt atcagtctgg gcggatctgt 234001 tcatctttgc ggcattttcc tgtatgatat agtaagagtg tgcatagcaa ctaactataa 234061 ttgaacaggg tgtttaaaac atggaaaaac aatacagagt attactttac tataaatatg 234121 ttccgattga agatccagag gcgtttagag agcagcatct ggctttttgt aaggagcttg 234181 gtttgttagg ccgtatcctt gtttcttctg aaggaattaa cggtacggta tcaggtacgg 234241 ttgaacagac tgaaaaatat atggaaacaa tgaaagctga tcctcgcttt gcggacatgg 234301 tatttaaaat tgatgaagca gaaggccatg ccttcaaaaa aatcttcgtc cgccataaaa 234361 aagagcttgt aacgcttcgt cttgaagatg atgtcgatcc gaacgaaaca acaggccagc 234421 atttgaagcc tgcagaattt tatgagaaga tgcaggatcc aaacacaatt gtcatcgacg 234481 cgcgtaacga ttacgagtat gaccttggcc atttcagagg tgcggtccgt cctgacatcg 234541 aagccttccg tgaattacct gaatggattg aagagcacaa agatatgctt gaaggcaaaa 234601 agattttaac gtactgtaca ggcggcgtgc gctgtgaaaa gttctcagga tggctggtga 234661 agcaaggctt tgaagatgta gctcagcttg atggcggaat cgtgacatac ggaaaagatc 234721 cagaggtgca aggcaagctt tgggacggcc agtgctacgt atttgatgaa agaatcagcg 234781 tgcctgtcaa ccgtgtcgag catgtgattg tcggcaagga ctactttaca ggagaaccgt 234841 gtgagcgtta tgtgaactgc gcaaatccat cttgcaataa aaaaatgata tgcacaccgg 234901 aaaatgagta taaatatatg cgcagctgca gccacgaatg ccgcacgaac ccaagaaacc 234961 tgtatgtgaa agagcataat atgacagaag aagaagtaaa cgcaagactg gcagcgattg 235021 aaacagaaga tcacgctgct gctgaataaa aaaagaacac ctcgtattga ggtgttcttt 235081 ttttctatat gctttcagtt tggctgtttg cggaaaccca ttctttttgg cggaaggcct 235141 tttcccattt tgataccacg atacaggcga tcgcatgtcc cggtacgttc acgcctgttc 235201 tcgccatgtc catgacgcgg tcaacacccg cgataatggc aacgccttca gccggcagtc 235261 ctacagcatt ggcagtcgcc agaagaacta caagcgatcc tgagggtaca gctgcaatgc 235321 ctttactggt catcacaagc acaagcatca tgagcagctg ctgggacaat gtcatgtcta 235381 cttgaaaggc ctgtgcgaga aagatacaag aaaccgataa atataagctg gagccgtcac 235441 agttcaatga caagccggag ggaacgacaa atgataccac tcgtttggga cagccgtatt 235501 tctccattct atccatcagc tgagggagaa tggtttcagt gcttgtggtg gaaaatgcaa 235561 ttaaaaacag atcccatatc attttcaata cttcgaaata cttaatctga aagatgagac 235621 cgacaagcgg aaagaggaca aagaggatca ggaacaggcc aaggaatacg gtgccaacca 235681 gcttaaacat agggaggagg agttcaatgc catattggcc tacagaagca gccatcaggg 235741 ctaacacgcc gataggagca gtgaccatga cgatttgcgt gagcttgaac ataatctgag 235801 ctgtagattc aaaaaacttc attactggtt cagaagcttt gccgatacca gctgcggcga 235861 caccaaataa aatggcgaag aaaataacgg caagcaaatc atttctggcc atgacatcaa 235921 taatgtttgt agggataata tccaggatca tttgcttgaa atcaacaact ttgtctgtgt 235981 agccggaaag ttcatgaata tctttttttg ccaaatggga gaggtcaagc ccgacacctg 236041 gttttaagac attcgctaat aaaagtccaa gccctaatac caacgttgta atcacttcga 236101 accaaatgat cgtcttgatg ccgagactgc ccattttttt catgcttccg cttcctgcgg 236161 ctccaatgac aatggtagaa aatacaatcg gcacaacaat cattttaatc aggcggataa 236221 atccatctcc gacaggcctc agtgccatcc cgaaatcagg aaaaaagtgg ccgatcaccg 236281 cgccgacagc caaagcgatt aaaatttgaa acgcgattaa ttttttcaaa tgaatccccc 236341 tttagaacga tagaatgtag gcatattcat atcattcgtg attcaaatgc aaacaccttt 236401 tttcaagtta ttttattttg acagcgcttt cattatgttg gcgaaaaagt cccccgcagc 236461 aggggggact tttttacttc atttgaatgt gctttagatc ttcttcagag gtatttgtga 236521 aaataaccgg tgttatggct gaagcggcat gctgcttgat gtaattgaga tcaaaggtga 236581 gaagcagttc gccttgtttg acggcttgtc cgcttgtgac atgtgcttca aagccttccc 236641 cattcagttt gacggtatcg atgccgacat gaatcaggat ttcagtgccg ccggcgctca 236701 taaagccgat ggcgtgtttt gtcggaaaaa tcgagacgat ctcgccgtcc gcaggtgcaa 236761 cgacttttcc ttctgatggt ataatcgcaa atccctcgcc catcattttt tctgaaaaga 236821 cctgatcagg cacatcccct aaagagactg tttctccttt aatcggataa ataaaggtct 236881 catcggaatc gggcttcagc ggtttgtcag ttaccgtgtc cagcgcggcg gcggtggcag 236941 ggacgcctcc ggccatgatt gttttgatgt cgtcttttaa ggcatcggac ttggttccga 237001 atattgcctg gaagttgttg ttgacctcca gcacacctac tgcaccaagc cgttttaatt 237061 catccttgca gacttggctt ggctgatgaa cggtcacacg aagccttgtg atacatgcat 237121 ccaggttagc gatattttgc tgtccgccca aggcctgcag cacgtgaaag gcaagctggt 237181 cttttgcaac tggagctttc tcctcattct gaccgtcttc atctgtctca cggccgggcg 237241 ttttcaaatt ccatttcaga atcgcaaatc ggaacaaata ataataaatg aaagcaaaca 237301 cgatcccgac aggaatgaca acccagccgt ttgtagacag tccgtagttc aagacgtagt 237361 caattcctcc gcctgagaac gtatagccgt ggcggacatg gaataaatca caaacgacaa 237421 agatgacgcc ggcaagaata gagttaatca aatagagcac gggcgcaacg aacaagaaag 237481 aaaactcaac cggttctgta attccggtca gcatagatgt gagcgccgca gaaatcatca 237541 cgccggagat catttttttc ttttccggac gcgcggtatg gataatggca agagcaacgg 237601 ccggcagaca gaaaatcatg taagggaaat cccccatcat aaagcgcccg gctgtcgggt 237661 ctcccgcgaa aaaccttgtc aggtcgccgg ttacggtgtt gcctgttgat gggtctgtgt 237721 attctcccat cataaaatag aaaggcgtat aaaaaatatg atgcaggcca aaaggaatca 237781 gcaaacgata gatcgttgca taaaagaaca ggccgactgt tgaatcggca attaaactgc 237841 tggctgcgtt aattccgttt tggatcagcg gccaaacgaa tgagaaaatg acgccgatca 237901 ccaatgaact gacggaagta atgatcggga caaagcgttt tccagagaaa aatccaagga 237961 ccggatgcag ctcgattgat gaaaatcgct tatataaata ggcggcgaga agcccgataa 238021 tgattcctcc gaaaaccccc atatcaatca ggtgctcggc tccttcatac ggaggctgaa 238081 ggccgagtaa ttttcccata ttgtcgaggg tgacggttaa aattaagtat ccgatgacag 238141 cggcaagtcc ggctacacct tctccgccgg ctaatccgat cgcgaccccc acggcgaaaa 238201 tcagcggaag gttatcgaat acaacgccgc ccgcatcctt tataataggg atgttcagta 238261 aatccttgtc tccgaaacgg agcaaaagac ctgctgccgg caggacggca accggagtca 238321 tcaacgcgcg gccaagctgc tgcagaattt gaaatgcctt tttaaacatg acagtctcct 238381 tttattgtgt tatgagaatg atgcactctt taatttttga gctgctttat aatcggcgat 238441 aacggttaca tgattgtgtt tttgaagaat ggaggctggt acatctgtcg tgacaggacc 238501 ttcagccatc ttttgaatgg cgtctgcttt ttcctcgccg cttgctaaaa gcacaatatg 238561 tttgctgaat tccatgatgg ttttaatgcc cattgaaatc gcgagtctcg gaaccagcac 238621 cggatcgccg ccgaagaatc tggcatttgc ctgtatcgtg ctttccgaga gcttcacaac 238681 acgtgtccgg tcttcaaaat cagatcccgg ttcattaaaa ccgatatggc cattggcgcc 238741 gatgccgaga atttggacat caatgcctcc cgcctggcgg atgagatcct cgtatacttt 238801 gcatgccgcc tcaagctgcg gattgtctcc ttgcgggata tgaatatgat caggctgcat 238861 attgatatgc tgaaaaagat gctcatgcat aaaatggtta taactttgcg gatgagatgg 238921 agagagacca gcatattcat ccaaattaaa tgtagtaacc tttgaaaaat caatttcgcc 238981 tgcctgatag tctgaaatca actgcttata caagccgacc ggtgtgcttc ctgttgccag 239041 gccgagaacg gcatctttct tagcttgtat ttgttcttta ataatggcag cgcttaactt 239101 acagagttct tcgtagtgct cggcgatcag aatcttcatg tgacaccccc tcaaagagat 239161 agacaagcac catatttgtt atgaccaatt tatgatactt gtcattacga atttagcacc 239221 gcccttatca aactgtcaat attaatttct gaaaatttgt tataaaagaa ggatacaaat 239281 ctttcatatt gggagggcaa atggtattat ggtctcaatg aaaaagaacg gattgcatac 239341 agaatgggga gaatgaaatg acagctttat attctgttat caagtttaaa atcattgagt 239401 taattaaatc gggcaaatat caggcgaatg atcagctgcc gacggagagt gagttttgcg 239461 aacaatatga tgtcagcaga acaactgtga gactggctct gcagcagcta gagcttgagg 239521 gatatattaa aagaattcaa ggaaaaggga catttgtatc ggcggccaaa atacaaacgc 239581 cgattccgca taagattacg agctttgcag aacaaatgag aggacttcgt tctgaatcaa 239641 aagtgcttga gcttgtggtg attcctgccg atcattccat cgccgagctt ttgaaaatga 239701 aagagaatga acctgtcaac aagcttgtca gagtcagata cgccgagggg gaacctttgc 239761 agtatcatac ctcatatatt ccctggaagg cggcaccggg gctggcgcag gaggaatgca 239821 ccggctcgct gtttgaattg ttaaggacaa aatacaatat tgaaatcagc aggggcacgg 239881 aatcgatcga accgatttta acggatgaaa cgatcagcgg acacttatta accaatgtcg 239941 gagcgcctgc gtttttatca gaatccctta cctatgataa aaatgaagaa gtggtggaat 240001 atgcgcaaat tattacacgg ggagaccgaa cgaaattcac cgtagaacag tcatatcatt 240061 cataaagcaa tgtgttttaa gaagggaatg gtggttctat gtttttattt acgaatggaa 240121 aagtgctgtg gggagcagtg attgctgcat tcatcctttc aattgtattt tacccttttc 240181 tgccgacgca gatgccgatt cattatgatg ttgcgaacag tccggatctg acggttaaca 240241 agctggcggg gactgtgatg ctgcctgttt tgatggtggt gtttgcatgg gcgcggaaga 240301 tcaattggca atttgtattc gcagtgtata ttttgctgat ttgccacatt gtcgtccttt 240361 gtttagcgct ctaaatcaaa cagccagaat aaaactggct gttttcttta atttcagctt 240421 catctgacaa tgaatgtggt gtataatagc tgatgatcct aaagaatatt ctgaaattta 240481 taggtgtgaa gcggcgtatt attaaaggaa aggctgtata ctttttgcag ctttaaaaag 240541 actgaatatt taaacaatta tgtgaaaggt gtgctgatta gattgaataa gcttattgaa 240601 cgagaaaaaa ctgtatatta taaggaaaag cccgacccgt cttccttggg gtttggacaa 240661 tattttacag attatatgtt tgtgatggac tacgaagagg ggattggatg gcatcatccg 240721 agaattgcgc cgtacgcacc gcttacgctt gatccgtctt catctgtttt tcattacggc 240781 caggctgttt ttgaaggatt aaaagcatac agaacagacg acggcagggt gctgctgttc 240841 cgtccggatc aaaatatcaa acggctgaac agatcgtgtg agcgcatgag catgccccct 240901 ttagacgaag agctggtgct tgaggcattg acgcaattag ttgagctgga gaaagattgg 240961 gttccaaagg aaaaaggaac gtcactgtat attcgtcctt ttgtcattgc cacagaaccg 241021 agtctcggtg tgaaggcatc caggagctat acatttatga tcgtgctttc gcctgtcggc 241081 tcctattatg gcgacgatca gctgaagccg gttagaatct atgtcgaaga tgagtatgtg 241141 agggcggtca acggaggagt cgggtttgca aaaacggctg gaaactatgc cgccagtctt 241201 caggcacagc ggaaagcgaa tgaactgggc tatgaccagg tactgtggct ggacgccatc 241261 gaaaagaaat atgtggaaga agtagggagc atgaacatct ttttcgtcat aaacggggaa 241321 gctgtcacac ctgctttaag cggaagcatt ttaagcgggg ttacacgtgc gtctgcgatt 241381 gaattgattc gaagctgggg cattccggtt cgtgaagaga gaatatcgat tgatgaggtg 241441 tatgcggcct ctgcacgcgg agaattgaca gaggtctttg gcacaggcac ggcagcagtc 241501 gttacgcctg tcggtgaact caacatccat ggaaaaacgg tgattgtagg cgacgggcaa 241561 atcggggacc tctcgaaaaa gctgtatgaa acgataacag atattcagct tggcaaggta 241621 aaaggcccgt ttaactggac agtggaagtg tgaaaatcga aaaagaacct gcccggaggc 241681 aggttctttt tattttgaat gagtcatatc agcagccggc tggcttttgc ggttttttac 241741 ataatatatt gcatagcaaa tggccataaa tggaacgccg caatagagtg cgattctttg 241801 attcggatca aaggcaatgc caacgacgga agccaggcat aacaggaacg cagcaatcgg 241861 cacgaacgga tacaaagggg ttctgtattt caaatcagta accttgtttc ccgcttcgat 241921 ataacgtttt ctgaacatga attgagaagc agcgattccc atccacacga caacgacggc 241981 aaaaccggaa atcgacacga gcacaacgta tacagtgtct ggcgcaaata cgctggacag 242041 caacgacaga atgccgccga tcatgctgaa caccagcgcg ttaaaagggg ttccttttga 242101 cgtcagcttt gcaaatgtcg gatgaagcgt tttttctttt gataaagacc acagcatccg 242161 ggaagaagcg tagagtccgg aattagccgc tgacaggatc gctgtcagga taacaaagtt 242221 catgatatcg gctgcgtatg gtacaccgac tctgtcaaag acagcgacaa acgggctttt 242281 gatgacacct gcatcttgaa tcggaatcag ccctgacagc acaaaaattg ttccgacaaa 242341 gaagagcgag agacgccaga ccgttgtttt tatcgctttt ggtatcgtct tgtcaggatc 242401 aacgctttca ccggctgcga ttccgattag ttccgttccc gaaaaggcaa aattgacgga 242461 cagcatcgtc atcaaaatcg ggacaaatcc attgggaaaa agcccgcctt ccgccgtgaa 242521 gttggacagc atcggagcgg cttctccgcc tttgatcggg atgatgccga acatggcaga 242581 gccgcctaaa agaataaata atacaatggc taatactttg atgctggaaa accaaaattc 242641 tgattcagcg aaaaacttga ccgaaaatgc gttaagcaag aagatgaaca gcgcaaagac 242701 ggcactccac atccaaaccg atgtatgggg gaaccagcgc tgcattaaca ggccggctgc 242761 tgtgaattct gatcccaatg ccacggtcca tgtcagccaa tacagccaag cgaccgtaaa 242821 tccggtgccc ggccctatgt atttggctgc ataggtgtga aaggcgccgg tcacaggcat 242881 ggcgactgac agctcaccga ggcatagcat gaccagatag acgatgccgg ccccgactaa 242941 gtaggcgagt atcgttccgg ccgggcctgc ttgctgaatg gtataacctg agcttaaaaa 243001 cagcccggtt ccgatgacac ctcccaagga aagcataaag aggtgccggc ttttcatact 243061 tctctgaaag gttgtctcat tcttgttgtg ggcagagttc atctttttcc aactttctat 243121 cagcgattta tttccttcct aataaaaaat ctcatgtcag aaagtgacac gagactccgg 243181 cgaaccggct ttaagttaga atatacaaac tattccgata agtcaagttg tttttaaaga 243241 gcgggcccaa gccgcaattt cttgaatatt ttcgggtttt gtccggcagc agccgccaat 243301 cagcctcgct cctttttcat gccaggtgcg ggcgctcgcc ccgtaagatt ctgcgcatgc 243361 tgcgccgttc cacgtttttg tttccggatc atattgctca cctgaattcg ggtagacaat 243421 gatcggtttt gacgtgttct tttttaactc ctctatcaag gaagggatat gctgaagcgg 243481 cgtgcagttg atgccgagtg ctgcaatttg gcggtgttca tcaagccacg atgcgcagtc 243541 agctgcaggt gttccgtcac tgatatgcaa gccgtcttta gcactgaagc tgatccatgc 243601 atacgtttca ggaaattcct tcaacagccg aacaatcgct ttggcttcag tcagacacgg 243661 aatcgtttcg catgccaata catcagctcc ggcttcaatc agcgccttca tccgggggcg 243721 atgaaattca atcagttcat cttctgatat tgcgtagttg ccgcgatact cagacccgtc 243781 tgcaagataa gcgccataag ggcctataga agccgcaatg atcggttttg gccgattcaa 243841 acggttctct tcaagcgacc aaaattcatc acgtgcttca gctgcgatgc tgacggacaa 243901 ctcgatgagc cggcgtgctt ccgcttcgct cagcccgcgt gcggcaaagc cttcaaatgt 243961 agactgatag ctggcggtga ttgcacaatc ggcgcctgcc gcaaaataat cagtatgaac 244021 ttgtttaatc agctccggct cttccatcag gatttttgcc gaccacagac tgtcattcaa 244081 attacagccc ttgcgttcaa gctcggtcgc catggcgccg tctagcacaa taagcgggta 244141 tgtatctaat atgtgttgga taggattcat agaatgtacc gatgccttct ttcagatttt 244201 tttgaaaaag atatgaaaat cgtaatggag gcttacgtgt ttgtcaataa acgcaaaaag 244261 agaaaggtgt tcagcccata tgtctgaaca cccttttctt atgatatttg tttgttgtgc 244321 gtgtcagtct ttgtgtctga aaccggccag cactcaatgc cattatggtt tttgagcaca 244381 tctttataaa agaccggatc cttgcctgct tttttctggc gtgtatagtc tttcagcgcc 244441 gtaaaaacga cctttgatag taagaaaatc gcgattaaat tcacgatgac catcaaaccc 244501 atgaacaaat cagcaagatc ccagacgagc tggactttgg caacacagcc aaacacgatc 244561 attgccagca cgccgatacg gtagacaaaa atcagttttt tgcttttgtt caaaaagccg 244621 atattggttt cgccataata atagtttcca attagagcac agaatccgaa taacaaaatc 244681 agaatcgcga gaaagcctga tgcccatgat ccgacatggg agctgaggga ggcttgtgtc 244741 aaggcgattc cgctcagacc cggagtatga taggcatccg aaaacagaat gataaaagcg 244801 gtgcttgtac aaatgaccag tgtatctgtc agtacaccaa aagcttggat cagcccctgt 244861 ttgacgggat ggcttgttgt ggcggtggca gcggcatttg gtgcgcttcc cattcccgct 244921 tcgtttgaaa agattccccg tctgacgcct tgcatgagtg ccgcgcccaa agccccgccg 244981 gcggcctggt caaaaccaaa cgcatttttc acgattagcg caagcacacc tggcagctgc 245041 gtaatgttgg agaaaatgac gaaaaacgca actccgatat acaggacagc caatacgacg 245101 acaatggatt cagccagctt tgcaatgcgc ttgactccgc caaaaataat cgtgccgaat 245161 acagcaatta aaatgagtcc caatgtcagg cggtttgtgc caaacgcgtt ttcaaaggca 245221 aggctgactg tattggattg aaccgagttg aagacgatac cgaacgataa ggtgattaac 245281 acagcgaaca gcgcgcccat ccaccttttg ttcagccctt tttccatgta atacgccggc 245341 ccgccgcgga agccgtttac atcttttact ttataaatct gagccagtgt gctttccaca 245401 aagctggatg ctgatccgat aatggcgata atccacatcc agaagattgc accgggcccg 245461 ccgagtgcaa tggcgatagc aatgcccgta atatttcccg ttccgacacg ggccgccatg 245521 ctgatgcaaa aggcttgaaa cggagaaatg ctgttttttg accgggaagc agcaccttct 245581 cttaataccc tgaccatttc tttcagcatg cgaacctgta aaaacttaag cctgaacgta 245641 aaatagattc caaaagaaag gagcaaaaca attaatagct ttgaccacaa aagatcattt 245701 gcaataccga cgatatgttc taggatttgc tgcatagaat cacctctttt ttcatgttta 245761 aaaaatgctg agctcccatt cctgcgccat atgcttcagc agcataccgc cagtgaggct 245821 gttgccgtat tcatcaatgg caggcccgta aatgccgatg ccgcatccgg attgaaaagg 245881 ctgttctctt ctggcgcttg gaggcaccag cgccatgatg ccgccggaga cgccgctttt 245941 ggccggcacg ccgacaaacg ccgcatattt gcctgaagcg ttgtacatgc cgcacgtcag 246001 cattaatgcc ttggccaatt ttgccacatc ttttggaatc acctgctcgt gtcgaatcgg 246061 atgatacccg tcatgagcaa ggatcaggcc gatcaacgca atatcttctg tagtgctctc 246121 catagcgcat tgcttcaagt acacctcaag tgtttcttct acttcagctt ctaaaaagtt 246181 tgtttctttt aaatagtagg ccagcgctct gttgcggtgg gcggtttccc attcagaacg 246241 gaatacttct tcatgaattc ttggccgttt tcctatcaaa gtttccatca ccgagtaaag 246301 aaactcgagc ttttcgtatg cagattctcc gggaaggatc gaagcgatgg tgagggcacc 246361 cgcgttgatc atgggattga agggctttcc cggcttgttg atttcgagcc gaatgattga 246421 attaaaggcg tcacctgtcg gctcgacatc tacgcggtca agcacatagg gaatgccgcg 246481 gctcatgcag gcggcaataa agctaatcac ttttgaaatg ctttgcatgg taaaagagac 246541 gttccagtcg ccggcgtgta tcatcgttcc atcaggctcc aatacacaga tgccgagctg 246601 tgaatcattg acttttccta aagcggggat atagtttgcg ctttgtccat tggcggcaaa 246661 agggcgatag tattcaaccc aatcatgaag ctgtaacgcc gggtttatgt ctttctggtg 246721 ctcttttatc aattctttca tcgaattcct cctcactgat ttttttctta aaggactgag 246781 gtgtatcaaa acgaaggcta agggggcgtt aaacgctttc ataatagcgg aaggtataat 246841 tactgtataa tggagactac agaatcatac aaaatacgac aaaaacattt tgaaaataag 246901 cagtaagatt tataaaaacc tcatgttctg ggtcaaaagc aatttgcagg ttttctcccg 246961 attccccaaa ataaaaagcg aggatgtgat caacataaaa ctggaacggt ttattgaaaa 247021 agacggatat atactggccc tcatgctgat tacggtgccg ctggccggtg aactgaaatt 247081 ttatcccctc aatgaagaat tccgggtcag ctttggggca ccggtttttt tcttcttttt 247141 atcattgttg cggcatgtgc ccgctgtgct gccgggtttt ctgactggag cggctgtttt 247201 catctttcgc gtctttctgg aattatgggg cggaggacac aatgggctga ctccgattct 247261 gtatgatcaa gcgtctggct ttttctttta tatgacttac gcctgtctgt tttccatatt 247321 aaaggccaat cgtttccgtg aacggccgat tatgctcggt ttcattgggt ttatgattga 247381 agttgtgtca gattgtgtcg agctaactgt gcaatttctc atttttcata cggttgtcac 247441 gcctgagaaa atcactgaca ttgcggtgat tgcgatttct cacacattta ttgtgatgag 247501 cttttatagt gtgctgaagc tgtatgaaac acaatcgaga gaaaaacaga caaggcagca 247561 gcacgagcac atgctgatga tcgtttccaa tttatatgaa gaaacggtgc acctaaaaaa 247621 gacattgaaa acgacagaga aagtgacaaa cgattcgtat cagctctatc gggaaatgaa 247681 gggcaaggat gttcagctga gcggcagaat cctgagactg gccggagaga ttcatgaagt 247741 gaaaaaggac aaccagcgga tattcgcagg gctttcaaaa ctgatttcga atgagagttt 247801 gagagattat atgagggctt ctgatttgct gcagctcgtg attcgaatga atgaaaagta 247861 cgctgaagca ctagggaagc agattgattt ttactgctcg atcgagggag agcatgacga 247921 atatcacgta tttatcgtgc tttcgatcat taataatcta acagcaaatg cggtagaggc 247981 tatggatgaa gagggaatgg tcagcctgag gctccgtaag ccaaatgaga gtatggtaga 248041 attccaggtg gaagacaatg gccccgggat ttccgagaaa atcggagaca ttgtgtttga 248101 cccgggcttt acttcaaaat atgacgaatt tggcacgcct tctacgggta tcggactttc 248161 ctacgtaaag gaaatcgtga cagagctaga aggggatatc acgtttgata atcagcagcg 248221 gggagtggtg tttgccatca ggctgcctgt ccggcatttg attcagaaag ggtgaaccaa 248281 aagctatgcg tttttttatt gcagatgatg accgtgcggt gcggtcaatt ttaaggcaga 248341 tcattgagga cgaagatctc ggggaagctg ctggtgaagc agacgacgga agccaagtgg 248401 aagggcatat gctgcaattt aagcagattg atattttatt aatcgatctg ttaatgcccg 248461 gaagagacgg cattgagacg attcgtcaga tccagaatac gtactccggc aaaatcgtaa 248521 tgatctctca agtggaggcg aaggaaatgg tcggggaagc gtactcgctc ggcatcgaat 248581 attttatcca taagccgatt aaccgcattg aaattgtcac ggttctccaa aaggtgaagg 248641 agcggatcga gcttgaacac tcgattggag ccattcagca ttctctaagc cggcttgtca 248701 atcggactga acggaaagcg cgtccccagc agaagagtga cagcggttta aaagaggcag 248761 gaacattcct gttgtccgag ctgggcatga tgggagaagg cggcgcacat gatctcatgg 248821 cggtcctgca gtatttagca gaacacgagc aatccgagcc gcacgaaaaa caaagccctt 248881 cgctaaaaca aatattcacc caagtagcgg tacggaagct ggggacagga gcctcacaga 248941 cggaagtcaa tcgcgaaatg aaagcctcgg agcagcgtat ccgcagagcg attattcatt 249001 cgctgcacca ttttgcttca ctgggcacaa ctgatttttc gaatccaaaa tttgaaacct 249061 atgcatcgaa attctttgat tttccggttg tcagccagaa aatgaaagaa ctccaatcca 249121 aggatgcaaa accccttgca cctgctagaa taaatatgaa aaaattcatc cacgtgtttt 249181 ttttggaagc aaagcttttg catgagacga tgaaacaaag aaggatataa accaaacagc 249241 cggctgacca ggctgttttt ttgctgcgca gaatcccggc cggacagtga tttaccgctt 249301 ttttataaaa tatcagaaaa taaagatatt gacttattgt ttatttgtct tacaattaaa 249361 caaaaggata tatgggaagg agcggatgtg aaagaaaaat taataaaagc gcttacagat 249421 agaggccgta tacacaaata acaggaggtt atgttgatga gccgtatcag aaaagcaccc 249481 gctggaattt taggttttcc ggttgctcct tttaacacac aaggaaaact ggaggaagaa 249541 gctctttttc aaaacattga gtttttgctg aatgagggct tggaagcgat atttatcgct 249601 tgcgggtctg gtgaattcca atctctcagc cagaaggaat atgagcaaat ggtggaagtc 249661 gcagtctcgg cagccggagg aaaggtgccg gtctacacgg gggtgggcgg caacctcagc 249721 acagcgcttg attgggcgca gctgtcggag aaaaaaggcg ccgacggcta cttgattctg 249781 cctccgtatt tggtgcatgg cgaacaggag gggctgtacc agtatgcgaa aacgattatt 249841 gaaagcactg acttgaacgc gattctttat cagcgcgata acgcagttct ctctgttgaa 249901 cagatcaaac gtctgaccga atgtgaacag cttgtcggtg tcaaagacgg ggtaggaaat 249961 atggatttga atatcaatct cgtctatacg atcggcgacc gcttgggatg gctcaacgga 250021 atgccgatgg ctgaagtgac gatgccggct tatctgccga tcgggttcca ctcttactct 250081 tcagcgattt caaattatat cccgcatatt tcgcgaatgt tctatgatgc attgaaaaac 250141 ggaaatgacg agcttgtgaa ggaactctat cggcatgtga ttctgccgat caacgacatt 250201 cgcaaacaac gaaaaggcta cgccgtatcc ttgattaaag ccggtatgga aatcatgggt 250261 ttgaatgtaa ggaatacagc cagaccgcct gtcggcccgg ttgaaaaaga tcattatcag 250321 caattggaag caattttgaa gcaggcggct gaccgttttc cgaaaaaagc cgcgacggtt 250381 tgaccagaaa aaacacgaaa ggggcaatgg gcatgtctgt gatcacggaa caaaacacgt 250441 acctcaactt tattaacgga gagtgggtta agtctcaatc aggcgatatg gtcaaagtcg 250501 aaaaccctgc cgatgtgaat gatattgtcg gatatgtaca gaattcaacg gctgaagatg 250561 tggaacgtgc cgtcaccgcc gccaatgaag ccaaaacggc ttggagaaag ctgacgggtg 250621 ccgagcgcgg ccaatactta tacaaaacag cggatatcat ggagcagcgc ttggaggaaa 250681 tcgccgcctg tgcaacgcgt gaaatgggta aaacattgcc ggaagcgaag ggagaaacag 250741 cccgggggat tgccattctg cgctattacg ccggagaggg catgcgaaaa acgggtgacg 250801 tcattccgtc tactgacaaa gacgcgctca tgtttaccac ccgtgttccg ctcggtgtgg 250861 tcggtgtgat ttctccgtgg aacttcccag tggcgattcc gatttggaaa atggcgccgg 250921 cattggtata cggcaatacc gttgtcatca aaccggcgac agaaacagct gtgacatgcg 250981 cgaagatcat tgcctgcttt gaggaagcgg ggctcccggc aggggtcatc aatttggtga 251041 caggcccggg ttctgttgtc gggcaggggc ttgctgagca tgacggtgta aacgccgtta 251101 cgtttaccgg ttcaaatcaa gtcggaaaaa tcatcgggca agccgcttta gcgaggggag 251161 ccaaatatca gcttgagatg ggcggcaaaa accctgtcat cgtagctgat gacgctgacc 251221 ttgaagctgc ggcagaagct gtcataacgg gggccttccg ttcaaccggc cagaaatgca 251281 ccgcgacaag ccgtgtcatc gtacaaagcg gaatttacga gcgctttaaa gaaaaactgc 251341 tccagcgcac aaaagatatt acaatcggag acagcttaaa agaggatgtc tggatgggac 251401 cgatagccag caagaatcag cttgataact gcctgtcata cattgagaaa ggcaaacagg 251461 agggcgcttc ccttttaata ggaggagaaa agctggagaa cggaaagtat caaaacggct 251521 attatgttca gcctgccatc tttgacaatg tgacatctga gatgacaatt gcccaggagg 251581 aaattttcgg tccggtgatc gccttgatca aggtggactc gatagaggag gcgctgaaca 251641 tcgccaatga tgtgaagttc ggtttaagtg catccatctt cacggaaaac atcggccgaa 251701 tgctttcttt cattgatgaa atcgatgccg ggctggttcg gatcaatgca gaaagcgcag 251761 gtgttgagct gcaggcgcct tttggcggca tgaagcagtc gagctcccac tcccgagaac 251821 agggtgaggc agcgaaggac tttttcacag cgatcaaaac tgtttttgtg aagccgtaat 251881 ggtgctggaa agaggcgtgc gtctctttcc cggtttatca caaccagcat atgattctct 251941 actttgaaaa ggagaagata ctatgaaaaa agactttgcg agtgttactc cggcgggcaa 252001 aaaaacgtcc gtgcgctggt tcatcgtgtt tatgctgttt cttgtgacct ctattaacta 252061 cgcggatcga gcgacgcttt ccatcaccgg agattccgtc cagcacgatt tgggattgga 252121 ctcggtcgcc atgggatatg tcttttctgc ctttggctgg gcctatgtca tcggacagct 252181 tccgggcggc tggctgctgg accgttttgg ttcaaagact atcattgcgt taagcatctt 252241 tttctggtcg ttttttacgt tgctgcaagg ggcgattggc tttttctccg ccggcacagc 252301 gattatcctg ctgtttgcac tgcgttttct ggttggttta tcagaagcgc cttcatttcc 252361 cggaaacggc agagttgttg cctcatggtt tccaagctcc gagcgcggga cagcttcagc 252421 cttttttaat tcagcacaat acttcgcaat cgtcattttt tctcctttaa tgggctggct 252481 tacccactct ttcggctggc attccgtttt cgttgtcatg ggtattgcag gcattcttct 252541 ggctgtcatc tggctaaaaa cggtgtatga accgaaaaaa catccgaagg ttaatgaagc 252601 tgagcttgcg tacatcgaac agggcggcgg gctgatttcc atggatgaca gtaaaagcaa 252661 acaagaaaca gaatcgaaat ggccgtatat caaacagctg ttaacgaacc gcatgctgat 252721 tggcgtgtac atcgcgcaat actgtattac gactctcacc tatttctttc tcacatggtt 252781 tccggtatat ttggttcagg cccgcggcat gtctattctt gaagctgggt ttgtcgcttc 252841 cctgccggcg ctgtgcggat ttgccggcgg cgtgcttggg ggcattgtgt cagacatctt 252901 actcaaaaaa ggccgttcac tgacctttgc aagaaaagtg ccaatcattg ccggcatgct 252961 gctgtcttgc agtatgattg tctgtaacta cacagattca gcatggctcg tcgttgtcat 253021 tatgtcgctc gcgtttttcg gaaaaggctt cggcgcattg ggttgggctg tcgtgtcgga 253081 cacgtctccg aaagaatgtg caggattaag cggcggtttg ttcaacactt tcgggaatat 253141 tgcctcaatt acaacaccga ttattatcgg atacattgtc aatgccactg gatctttcaa 253201 tggcgcgctt gtgtttgtcg gcgctaacgc gattgcggcg atcctcagct atttgctgct 253261 ggtcgggccg atcaaacggg tcgtgttaaa gaaacaagaa caagaccccg atcaatcgtt 253321 gcctgtctaa tatttatgaa agcgctttat aaagggagga aaatgcatga gttcaccgat 253381 acaagagcag gttcaaaaag aaaaaagatc gaatattccc tcaatttctg aaatgaaggt 253441 gattcctgtt gcgggacatg acagcatgct gctgaatcta agcggagcac acagcccgtt 253501 ttttacccgg aatatcgtaa tcttaacaga cagcagcgga aatcagggag tcggcgaggt 253561 gcctggcgga gagcatattc gccgcacact ggagctgtca gagccgcttg ttgtcggaaa 253621 atctatcggt gcgtaccagg cgatattgca aacggtcaga aagcagtttg gcgatcagga 253681 caggggaggg cgaggaaacc agacgtttga tttgcgcacc actgtgcacg ccgtcaccgc 253741 actggaagcg gctttgttgg atttgcttgg aaagtttctt caggaaccgg tcgcggcttt 253801 gctgggcgaa gggaagcagc gtgatgaagt aaaaatgctc ggttacctct tttacatcgg 253861 cgaccgaaat cggacgacct tgccgtatca aagcgatgag cagtcagatt gtgcgtggtt 253921 ccgtctgcgc catgaggaag cgctgacgcc ggaggccatt gtgcgtcttg ccgaatccgc 253981 acaggagcgc tatggctttc aggatttcaa attgaaaggc ggggtgctgc ggggagaaga 254041 ggaaatcgaa gctgttaccg cattatcgaa acgttttcca gaggcaagga tcactcttga 254101 tccgaacggg gcatggtcat tagaggaagc tattgcatta tgcaaaggaa agcaagatgt 254161 gctcgcgtat gcggaagatc catgcgggga tgagaatggc tactccgctc gtgaagtaat 254221 ggctgaattc cgccgcgcga cagggcttcc gactgcgaca aatatgattg cgactgactg 254281 gcgggaaatg ggtcacgcga ttcagctcca cgcggtcgat ataccgctgg ctgatccgca 254341 tttttggacg atgcaagggt cggtgcgggt tgcgcaaatg tgccatgatt ggggtttgac 254401 atggggctcg cactccaaca accactttga tatttccctt gcgatgttta cccatgtggc 254461 agcagcggct ccggggcgga tcacggcgat tgatacccat tggatctggc aggacgggca 254521 gcgattaacg aaacagcctt ttgagatttc ttctggctgt gtcaaggtgc cggataagcc 254581 tggactaggc gtcgatattg atatggaaca agtggaaaaa gcgcatgaga tctatcggaa 254641 aatgaattta ggcgcacgga atgatgcgat cccaatgcag ttcctgatca gcaactggga 254701 atttgaccgg aagcgcccgt gtcttgtgcg ataagtttga ttgtaaatat tgtcatatcc 254761 gctattttgt cttacaattg aacaactgaa gggagagttg ttcgtgtacg aaggtttaga 254821 ggatttgaaa gtcgatacag tcaatcggaa aacattagcc aagcaggtca tcgaacggat 254881 tgtccattta ttatcgagcg gacagttgag ggccggagac aaattgccga cagaaatgga 254941 actgatggac attttgcatg tcagcaggcc ggtgctacgg gaagcactca gttcacttga 255001 aacgctgggc gtcattacga gaaaaacacg agggggcaca tatttcaacg ataaaatcgg 255061 catgcagcca ttttccgtca tgcttgcttt ggccactgat aatcttccgg ctatcattga 255121 agcgcggatg gcgctagaac tcgggctcgt gacaattgcc gcggaaaaaa tcaatgagga 255181 agagcttcag cgtttgcaga agacgatcga cgatattgcc aacagcactg acaatcatta 255241 tggtgaagcg gataaagagt tccatcgaat tattgcgtta agcgccaata accccgtcgt 255301 tgaagggatg attcagtccc tgctgatcac ccatgcgaaa attgacagcc aaattccgta 255361 cagggagaga gatgtaacgg tcgaatatca caaaaaaatc tacgacgccc ttgccaaaag 255421 agatccgtac aaagcacatt accacatgta tgagcatctg aaatttgtcc gtgacaaaat 255481 tctaaaagga atggatgaaa aataatggtg agcaaccgca gttgaaacgt aagagctgcg 255541 gtttttttaa accaatttag aaaacgctta ctaaaatatg aggagtgatt ttcatatggc 255601 gatgaacctc aggaagaacc aagcccccct ttacatcaaa gtgcatgaaa tagataacac 255661 cgcgattatt gtaaatgatg gagggctgcc aaagggcact gttttctcat gcgggctcgt 255721 acttgaagag gatgttcctc aaggccataa ggtggccctc accgatctca atcaagggga 255781 cgagatcgtg cgttacggag aggtgatcgg atttgctgat gagacgatca aacgcgggag 255841 ctggatacgg gaagccctcg tgagaatgcc cgctcctccg gcgttagacg atcttcctct 255901 cgcaaacagg gtgccgcagc cgcggccccc acttgaagga tatacatttg aaggataccg 255961 aaatgcggat ggcagtgcgg ggacaaaaaa tatcctcggc atcacgacaa gtgttcaatg 256021 tgttgttggc gttttggatt atgcagtcaa acgaataaaa gaagagctgc tgccgaaata 256081 cccaaatgtc gatgacgttg tgccgctgca tcatcaatac ggatgcggcg tggcgatcaa 256141 tgcgcccgac gctgtcattc cgatccgcac gattcaaaat cttgcgaagc atccgaactt 256201 cggcggtgaa gtaatggtaa tcggattggg atgtgaaaag ctcctcccgg aaagaattgc 256261 ctccgaaaat gatgatgaca ttctatcgct ccaggatcac cgaggttttg cggcgatgat 256321 ccaatccatt ttggaaatgg cggaggaacg gttaatcagg ctgaacagca gaacccgggt 256381 gtcatgccct gtttcggatc tggttatcgg cctgcaatgc ggcggcagtg atgcgttttc 256441 cggcgtgacg gcgaaccctg ccgtggggta tgcggctgat ttattggttc gcgcaggtgc 256501 aacggttttg ttttctgaag tgacagaggt gcgggatgcc attcatttat taacgccgcg 256561 ggctgtcagt gaagaggtcg gacaatcgct gatcaaagag atgaagtggt atgacagcta 256621 tcttcggcgg ggagacgcag accgtagcgc aaacccgtca ccaggcaata aaaaaggcgg 256681 attatccaat gtggtggaaa aagcgttagg ttcggtagcg aaatcaggca caagccccat 256741 ctccggcgtg ctcggccctg gtgaaagagc aaagcaaaaa ggcctgctgt tcgcggcgac 256801 accggcaagc gattttgtgt gcggcaccct gcagctggct gcgggcatga atttgcaggt 256861 gtttacgaca gggagaggaa caccatatgg cctggctgct gcgccggttc tgaaagtatc 256921 gacgcggcat tccttatcag agcattgggc tgatttaatc gatatcaatg ccggccgaat 256981 cgcgacagga gaggccagta tcgaagacgt aggctgggaa atcttcagga cgattttgga 257041 tgtggcaagc ggccgcaaac aaacgtgggc agaccgttgg ggtcttcata atgatttgtg 257101 cttgtttaat cctgctccag tgacttgatt catgttttta tagcggaaag atggaatatg 257161 ctgtaaaatg aaaatcagcg tataggaaac ggaggggtta cagcatggca ttcattagat 257221 tccgagtgac acgaattcaa tagtgaacaa ctctcgcctg aatgcgagag aatcgggatg 257281 aatccgccta tgtatgagcc cttatatggt tatcaaaaaa gagggtggcg tgcctgccct 257341 tttttgtgcc ttcaagcatc ccttctctct actgcaggcc ggagcatgag aaaggggaaa 257401 tgggatgaca aaccttaacg aaaaacagct tatcactgag attgtcgggc ttgcacgcag 257461 ccaaggtttg acggttcatt ctgagaacgc gcaattgaat gaaaccggaa tggactttca 257521 agttgtattt gccaaggacg acacaggtat gccatgggtg ctgcgaaaac cgcggcgaag 257581 tgatgttgtg gaaagagcat ctgcagaagg cataacgctt gcctttctcc gcgcgaatct 257641 gactgctgat gtgccggatt ggagaattca tacaccggaa ttgatcgctt accccatgtt 257701 aaaaggaacg ccggctgctg gaattgactt ggaacaaaag caatatgtat ggaatatgga 257761 tcatcagccg ccgtcagacg actttgtccg cacacttgcc gacatactgg ctgaattaca 257821 tggcacggat caaatatctg ctgggcaatc cggaatagaa gtgataaggc cagaagattt 257881 caggcaaatg acagcagact ctatggttga tgtgaagaat aagcttggcg tatctacgac 257941 gctttgggaa agatggcaaa agtgggtaga tgatgatgca tactggccgg gtttctcttc 258001 tttgatacac ggcgatctcc acccgccgca tatccttatc gatcaaaatg gacgtgtcac 258061 aggacttctg gattggacag aagcgaaggt tgctgaccca gccaaggatt ttgttcttta 258121 tcaaaccatt ttcggagaaa aagaaactgc ccgtttgctt gaatactatg atcaagcagg 258181 cggccgaata tgggcaaaaa tgcaggaaca catctcagag atgcaggcgg cgtatccggt 258241 ggaaatcgcc aagctagctc tgcaaacaca gcaggaggaa cacatcaata tggcgctgga 258301 agcacttggt gtaacatcgg attaagaatt gacttcgttt catgaaccga gtattataaa 258361 ctctacaaat aatagaacgg attaacaatc gtgaggaaga gcaagtacgc atcagaatgg 258421 aggttcagag agtcggtggc aggtgtgaac cgatcctccc ctgatgccga atgggcttct 258481 gaattgcttt gctgaacgga tagtaggcga tgccgggttt ctctccccgt taccaagaga 258541 ggagtatcga aacataggtt ttctgtactt agagtgaacg gctgtatagc tgttaataaa 258601 ggtggtaccg cgagaccctc gtcctttgca taggacgggg gttttttgtg tttcttaaag 258661 gaggtgacgg ccaatgtacg atggctggtg gtggcatagc agatgagtta gaaaggagga 258721 tatcaaatgg tcattgcaac tgatgatctt gaggtcgcat gtcctaaatg tgaaagagcg 258781 ggagaaatcg aaggaacacc ttgcccggcc tgcagcggaa aaggtgttat tctgactgct 258841 caaggatata cgcttctcga ttttatccaa aagcatttga ataagtaaag gagaaaagct 258901 gagctgagat gagagcagaa gagcagagta agattcgtga ggccgcagca ggtacgattt 258961 ttttgctgat cggaacagtt tgttttgcgt ctaaatcgat ttggataaaa tgggcatacc 259021 aaatgggtgc tgagccagat gccgtgctgc tatacaggca gctgctggct gttccgctgt 259081 tttggctgat ttttttaata taccgtcctc caatgccaga cggtaagaaa aaaggagacc 259141 tatggaaggc ttgtggcgcg ggagtgtttt gtttttttct gtctcccttg cttgatttta 259201 tcgggctgaa ccatgtatcc gcaatggttg aacgtatatt gctgatgagc tatccgttgt 259261 ttgtgtttgg attcaccgcg tgtcgtgacc ggaaaatgtc ctcaattcag gaccttttcg 259321 cagttctggc ggtcatgttt gggcttttct tggcgctggg cggctggaat gctgagcttt 259381 tccaggcgaa tatgattgga gctgtattca ttttgttatc ttcggccgtc tatgctggtt 259441 atcttgtcct ttccgggcat ctcgtccatc aaatcggagg gatccgtctc aatgcatacg 259501 ggatgacagc tgctggagct gccatgatgc tttacacagg gataaaatcg gcggctggca 259561 tgaatacgcc aatggcagca tatccgcttt ctatgtatgg tttgttcgca gtaattgcag 259621 tcgttaccac agtgattcca tttgtgctaa tgcttgaggg cataaaacga atcggggcac 259681 agcgagccgc cgccatttca atggcagggc ctatcctgac gattttctat ggagctttat 259741 ttctcggtga acggctcggg ctcattcaag tcattggatg cggtggcgta ttttttgtca 259801 ttacgggcat ggaatacagg aagctgaaaa caggaaaaaa agaataattt ttataaaaca 259861 cacacgtttt tcaattacaa taagtgtaat tacgtgtgtg ttttttgatt ttgtaaaggt 259921 taggtgagga gatgcagcgc atattgcttg tagaagacga ccactcaatc agtgaaatgg 259981 tggatcatta tttaacaaaa gaaggctttg gaattgtgca tgctttcgac ggagaagagg 260041 gcatccggct gtttcagcag ggttcatacg atttggtcct ccttgatatc atgctcccga 260101 agctgaacgg catggatttt ctgaaaatca tccgggaaaa aagcaatata ccggtcttaa 260161 tgatttcggc aaaagatgga gatgtggaca aggcattggg actgggcttt ggggcggatg 260221 attatatcgc caaaccgttt tcgatgattg agctgacagc ccgagtaaaa gccgcgatac 260281 ggcgggcgac gcaatattcg gcagaggagc cggctgtgaa taaggtgatc cggattcacc 260341 agcttgcgat agatatagac aatgtttccg ttttgaaaaa cggagagccg ctccagctga 260401 cgtcaacaga atggcagctg ctgtgcttat ttgcatcaaa tcctaaaaaa gtgtttacga 260461 aagaacaaat ctaccgttcc gtttggaatg aagagtactt tgatgatcag aacatcatta 260521 acgtacatat gcggcggctc agagaaaaga ttgaggatga cccctcctcc cctcaatata 260581 ttaaaacgtt atggggcatc ggttataaat taggagagtt ttagaatgac agtgctatgg 260641 gtggccgctg tcatcgctct ggcgtgtctg aatgtgattc aattcataat gaaaaagaag 260701 cgggacggga atctggctta cacggctgac cagcttagct acatgctcag ccgggattcg 260761 gcaggacaaa ttttgcttcc tacagacgat catgcgctca aagacttgct tgttaacatc 260821 aatcttatcg ttgagaatcg tcagcagatc agcgcccaat ttgccaaaac agagcaatcc 260881 atgaagcgga tgctgaccaa tatgtcgcac gacctgaaaa cgccgttaac ggtcattctc 260941 ggttatattg aagccattca aagtgacccg aacatgccgg acgaagagcg ggaaagattg 261001 ctggggaagc tccgccagaa aacaaatgaa cttattcaga tgatcaattc cttttttgat 261061 ttagcgaaat tagaatctga agataaagag atcccgatca ccaaagtaca tatgaacgac 261121 atatgcaaac gaaatatcct gcactattat gacgctgttc agtcaaaagg ctttcaagca 261181 gccatcgata tccccgatac gccggtgtat gcgcaggcga atgaagaggc tctggacaga 261241 atcctgcaaa acctattgtc caatgcgatt caatatggcg cggccggcaa gttaatcggg 261301 ctgacgctgt cttatgatga gaggaacatc gccatcaccg tatgggatcg cggaaaaggg 261361 attagtgaaa ccgatcagca gcgggtgttt gagaggctgt acacactgga agaatccaga 261421 aataaagcat ttcaaggaag cggcttgggt ttaaccatca caaaacggct tacagaaaaa 261481 atgggaggca tcatatccgt ccaaagcaag ccgtacgaac ggactgcatt tacgatcaca 261541 ttgaaacgca tgacatatta atcgtaagaa tttcttaagg tttgagaaat aaaaatgaca 261601 gggctcgccg ctacaataga aaacaggaaa agagagggaa ggagaaacaa agttgactta 261661 tatcgtacaa acaaacgggc tgaccaaaac atatcagggc aaagaggtcg tatccaatgt 261721 cagcatgcat attaaaaaag gtgaaatcta tggctttctc ggcccgaacg gcgcggggaa 261781 aacaaccatt atgaaaatgc tgacgagcct tgtcaaaccg acaagcggtg aaatcatcat 261841 ccttgggaac aagttcaccc acacgtcata tgaggtgctg gggaacatcg gcagcatgat 261901 tgaatatccg attttttatg aaaacctgac agctgaagaa aatttagatc tgcattgtga 261961 atatatggga taccacaata aaaaagccat acaagaagtg ctggatatgg tgaatttaaa 262021 acaaatcgac aaaaaacccg tcaaaacctt ttccctcggg atgaagcagc gccttggaat 262081 tgcgcgtgcc atcctcacga agccggacct gcttattctg gatgagccgg tgaatggtct 262141 tgaccctctc ggcattaaaa agatcaggca attgtttcaa gtgctgagca aagagtacgg 262201 gatgacgctg ctgatctcaa gccacctgct gggtgaaatc gaacaaatcg cggacacaat 262261 cggcgtcatt cgggacggca ggctgcttga agaggtatca atggaggatg tcaggggcca 262321 gaacactgaa tacatcgagc ttgtcacgcc gaatcagaca agggcctgct ttgtgctgga 262381 gaaagagctg caattaacca actttaaaat attaaatgag aaaacgattc gaatttacga 262441 ggctgaagcc tctcaggctg ccatatccaa agcattgatt ttaaatgatg tagacattga 262501 atcaatgaac aaaaagtata cgtcgctgga ggattatttt atcaaattga tcaacggcaa 262561 tagcatcagt gcgtaaagga ggagagacac gttgatgaat ttgatcagaa tcgaattaag 262621 aaaaatgaaa atgggctggt atatcagagg tgccctcatt gccaacgtga tcattatggg 262681 ttttatgtgg ctgatcagtt attccgaaaa agccgatggc ggggtttcgt tccaaagtac 262741 ggatgaagca ttcctcatca tcggcacctt cgtcagagcg gtatttatcg tatttggcgc 262801 tgtgctgatc gtaaaattgg tgatttcgga atataaaaac aaaaccattc ttgtgatgtt 262861 cacgtacccg atcagccgta aaaagctgct caccgctaag ctcatgatcg cgggcggact 262921 gacgtttatc acgattttac tttcaaatat actcatagcc gccggtttct tttggctgaa 262981 ctcgatctgc catttcatac cgggagagct tacttccgag atcatttctc aacaggcggt 263041 caaaatggcg gttttcgctt ttggcgccgc tggaaccagt ttagttccca tcttttttgg 263101 gatgcgtaga cactcggttc cggcgaccat catttcatct gtagtaattg tgatgctcat 263161 cagctcaaca agtccgggct tctcgatttc atctgttgtg tatatcccgt tatcgttagc 263221 ggcattcggt ttgttctttt cctacatggc gatcaggaat gcggacaagc aggatgcgta 263281 aacaaaggcg cccaatatgt ataaaaggcc gatgctgtca gcaccggcct ttccattatg 263341 agtctgttct tgtttcaaga taatgcttct tgccaatctc tttgctcatc atatagaaat 263401 ggaagcaata ttcaccgatt gccatgacga tcgcgccgaa taaagccgcc aatgcaactt 263461 caccgccagt catccccata gaaagcggca tgcccatcag ccagatcacg agaaaggcca 263521 aaccaaaatc agccaaagtt gcaatcatat tattccattt cggcaataca taaagatcgc 263581 ccagcaaata agaaataacc cctaacacaa tcgtcattag cagcgtatca ccaaacgtga 263641 aaccaaagcc cagaccaagc accagataca acacaataat cgtcataata cctttaatag 263701 cgagcgcttt cacatgtgtc attacaattc ctccttttgt catttgattt gttatgtata 263761 attcctcaaa tgtaaaaagt taaaccttat ttcttttcgg aggcgggtgc aaatctgctg 263821 gggagaggtc aatgatgtga atccaggaat tgaggctgcg gcgcttcgac agcggaaacg 263881 tgaagcttgt actgcaccgg acgctgcttt gatgcccaac agcccattat gtttgctgtt 263941 tttagatgaa taaatttaaa aacttctcct gtccctccgt catcacttct gaagtaatga 264001 aatatgatga aaagagatca aggggaggtg acgtgatggc ggtcgtgaga gcaacgagtg 264061 cggatgtcga tttgatggca aggctgctca gagcggaagc ggaaggcgaa ggcaagcagg 264121 ggatgctgct tgtcggcaac gttggaatta atcggctgcg ggcgaattgc tcagatttta 264181 aaggcctccg caccatcagg cagatgattt atcagccaca cgcgtttgag gctgtgactc 264241 atggatattt ttatcaaagg gcgcgagata gcgagcgtgc ccttgcacgc cggtcgatta 264301 atggtgaaag gcgctggcct gcaaaattta gtttatggta cttcaggccg cagggggact 264361 gtccagccca gtggtataac cagccgtttg tggccagatt taagtcacac tgcttttatc 264421 agccgacggc ggagacgtgt gaaaatgtat ataacacatt ttagagacag gacaccgttc 264481 aaattgaacg gtgtttttct ttgaaaagat gcaatgcaaa atattcctgt gagataatca 264541 aagaaaaaag agctgacgga gatgacagaa tggcaacaat tgacctgcaa aagaaaagtg 264601 taaagatcgt actggagaaa aagcagttaa cgaaggtgac ggctcgtgtt ggactggttc 264661 ttgatattac gggatcgatg agaccgctct acaaaaacgg gacggttcaa aatgtggtgg 264721 agcggatttt ggcagtggct gatcagtttg atgataacgg tttgctggat gtatgggtgt 264781 atgataatga attttcccga ttaaagccag tttcagaaaa ggatttttcg ggctatgtcg 264841 atcgtgaaat tttaaataat gaccgcttgc ataaattcgg cagaaatgat gagccgccag 264901 tcatgaagga cgtgctgcgc aaatatgtta cggaggaacc gagctcgtat cctgctttca 264961 ttgtttttat caatgacggg ggctgtaaaa agtcaatcaa accgataatt gaagcttctt 265021 ctgataaacc ggtgttctgg cagtttgtcg gcatcggaaa cggaaacttt gattttctca 265081 ataaactgga tacgttagaa gggcgtgtca ttgataacac gaacttcctg catatcgaag 265141 agattgaccg catttctgat gatgagcttt atgatgctct gcttgctgaa tttccatttt 265201 ggctgaaaga agcgaaggaa aaagggattg taagagaaca agagcctcct gctgaaaagc 265261 cgaaaaagaa gggctttttc agcagattgt tttcgaaata actgataaag agcactgagt 265321 cattctgcga aatggctcgg tgtttttgtt tttttaagat catgtgaaga aaaataggcc 265381 gaatgggcgg cttgcaaacg acaggatatg cagaaaacgc gtcattcagc cagctttcgg 265441 catgtttcag cagcaggctt gtgagggaag acctgttttt aatgttcagc gcttacaatc 265501 agttcacact tcttcacagt cgtttaacaa tgatttccta taatggagac gatcaatgag 265561 gagagagggg atcttgaatg gcatacgaca gtcgttttga tgaatgggta cagaaactga 265621 aagaggaaag ctttcaaaac aatacgtttg accgccgcaa atttattcaa ggagcgggga 265681 agattgcagg actttctctt ggattaacga ttgcccagtc ggttggggcc tttgaagtaa 265741 atgctgcgcc taacttctca agctatccgt ttacattagg ggtagcgtca ggtgatccgc 265801 tttctgacag tgtcgtgctt tggacacgtc tggcaccaga tccgctgaat ggcgggggaa 265861 tgccgaagca agcagtgcct gtcaaatggg aggtcgcaaa ggatgagcat ttccgcaaaa 265921 tcgtaagaaa aggcactgaa atggctaaac caagtcttgc ccattccgtt catgtggaag 265981 cggacgggct tgagccaaac aaagtgtact attaccgttt caaaaccggc catgaactaa 266041 gccctgtcgg aaaaacaaaa acactgcctg cccctggcgc caatgtgccg caaatgacct 266101 ttgcatttgc ttcctgccag caatatgagc acggatatta tacggcctac aagcatatgg 266161 caaaggaaaa gcttgatctt gtcttccatc tcggtgatta catatatgaa tacggcccaa 266221 atgaatatgt atcaaaaaca ggcaatgtcc gcacgcacaa cagcgcggaa atcattacgc 266281 tgcaagacta tcggaaccgt cacgctcaat accgttctga cgccaatctt aaagctgcac 266341 atgcggcatt cccttgggtt gtaacttggg atgaccatga agttgaaaac aactatgcca 266401 ataaaatacc tgaaaaagga cagtcggttg aagcattcgt gctccgccgc gcggcagcat 266461 accaggcata ctatgaacat atgccgctcc gcatttcctc tttgccgaat ggcccagata 266521 tgcagctgta ccggcacttt acgtacggaa acctggcgtc cttcaatgtg cttgataccc 266581 gccagtacag ggacgaccaa gccaataacg acggcaataa gccgccttct gatgaatcgc 266641 gcaatccgaa tcggactctg cttggaaaag aacaggagca gtggctcttc aacaatttgg 266701 gcagctcgac agcccactgg aatgtgctgg cgcagcagat tttctttgcc aagtggaatt 266761 tcgggacaag cgcaagcccg atctacagca tggattcgtg ggacggctac ccggctcagc 266821 gcgaacgggt tatcaatttc attaaaagca aaaatctgaa taatgttgtc gtactgacag 266881 gtgatgtaca cgcaagctgg gcatcgaatt tgcatgtcga tttcgagaag acaagttcaa 266941 aaatattcgg agccgaattt gttggaacct cgatcacttc cggagggaac ggagcggata 267001 agcgagcgga tacggaccaa attttaaaag aaaatccgca catccagttc tttaacgact 267061 atcgcggata tgtccgctgt acagtgacgc ctcaccagtg gaaagccgat tatcgggtga 267121 tgccatttgt gaccgagccg ggcgcagcca tttccacgcg ggcttcattc gtttaccaga 267181 aagaccaaac cgggttgaga aaggtatcat ccacaacaat ccaaggcggg gtgaagcaat 267241 ccgatgaggt cgaagaggat cgtttctttt cgcacaacaa agcccacgaa aaacaaatga 267301 ttaagaagcg tgcaaaaatc acgaattaag gagtggaaat tatgttttca aacattggaa 267361 taccgggctt gattctcatc ttcgtcatcg ccctcattat ttttggccct tccaagctgc 267421 cggaaatcgg gcgtgccgcc ggacggacac tgctggaatt taaaagcgcc acaaaatcac 267481 ttgtgtctgg tgatgaaaaa gaagagaaat cagctgagct gacagcggta aagcaggaca 267541 aaaacgcggg ctgaatgctg atgaggcaga caccgggtct gcctcttttt ttatgaaagg 267601 gagggctttt ttgaatggat aaaaaagaaa cccatctgat cgggcattta gaagagcttc 267661 gccgccggat tatcgtcacc cttgcggcat tttttctatt tctcatcacg gcttttttgt 267721 tcgtacagga catttatgac tggctgatca gggatttgga tggaaagctg gctgtgctag 267781 gaccgagtga aatcctctgg gtgtatatga tgctttccgg catttgtgcc attgcggctt 267841 ctatccctgt tgccgcgtac cagctgtggc gtttcgttgc accggcgctg actaaaacgg 267901 agcgcaaggt gacgctcatg tacataccag gtttatttgc gttgtttttg gcgggcatct 267961 ccttcggata ctttgtcttg tttccgatcg tgctcagctt tttgactcat ttatcctccg 268021 gccactttga aacgatgttt acggctgacc gctactttag gtttatggtg aatttgagcc 268081 tgccgttcgg cttcttgttt gagatgccct tggtggtgat gtttttaaca aggctgggca 268141 tcttaaatcc ttacagactg gccaaagcga gaaagctttc ctattttctg ctgattgtcg 268201 tgtccatatt gattacaccg cctgatttta tttctgattt tctcgtgatg atcccgcttc 268261 ttgtcctgtt tgaagtgagt gtcaccctat cggcgtttgt ctacaaaaag aggatgaggg 268321 aagaaacagc ggcggccgct tagtgcagcg taccacccgg tgacttcaca tcctcatcat 268381 attgtgcggc cgtaacagcg gcgattctca atgcccggac aatcgtgtcc aggctgaggc 268441 tcggcgctgt tttgtcgatt gtttgctgcg gaatgtaagg aatatgaata aaaccgccgc 268501 gaatgtgtgg ggatgtccgg ctaatgtgat ccattaaccc gtagaacaaa tagttgcata 268561 caaaggtccc cgctgtgtag gaaaccgcag ctggaatgcc gtgttccttc atcttagcag 268621 tcattcgttt cacgggaagc cttgtccagt aagcggcggg cccatctgga gaaatctctt 268681 catcaatcgg ctgatgtcct tcgttatcgg ggattcgcgc atctgcaagg ttgattgcca 268741 ctcgttccgg tgtaatctgc atccgtcctc ctgcttggcc gacacaaatt acgatatctg 268801 gctgatgttt ttgaatggct tggcgcagag tgtccagagc ggatctaaag acggttggaa 268861 tttgttccgc tgtaataatg gcttcttctg tctcgaagcc attaagccgt ttcgccgctt 268921 cccatgatgg attgacggtt tctttgtcaa aagggtcaaa gcctgtgatc agcacttttt 268981 ttctcattct cccatctcct ttttctttta ttctattgtt tatttatggg tttttcatca 269041 aaataatgta aaggagtgaa tcataatgga gcatttgccg gagcagtatc gccagttatt 269101 cccaaccttg cagacgcata cgatgcttgc cagctgttct cagagcgcat tggcagagcc 269161 tgtatcaagg gcgatccagg attattatga tagcctgctg tataaaggga cgaactggaa 269221 agaagcgatt gaaaaaacag agtttgcgag aaacgagttt gcaaagctga tcggggctga 269281 accggatgaa gtggcgattg tgccgtcagt ttctgatgca ctggtttctg tagcatcgtc 269341 cttaactgca tttggaaaga agcacgttgt atatacagat atggattttc cggcggtgcc 269401 tcatgtttgg caggcacact ccgattatac cgtatccgtc attccatcaa tagacggcgt 269461 gctgccgctt gaacaatatg aaacgcatat ttcggatgaa acagtactga cgtgtgttcc 269521 tcacgttcat tatcgtgacg gctatgttca ggatataaaa gcgattgccg agatttctca 269581 gagaaagggc tctttattgt ttgtagatgc ttatcaatca gccgggcata ttcccattga 269641 tgtgaaggaa tggggcgtag atatgctggc agcaggcacc cggaagtatt tgctcggcat 269701 accgggtgtg gcgtttcttt atgtgagaaa ggagctggct gacgcactga agccgaaagc 269761 atcagcttgg ttcggaagag agagcggatt tgatggggct tatgcaaaag tcgcgcgccg 269821 ttttcaaacg ggcaccccag cttttatcag cgtatacgca gctgcagcgg ctttatcgct 269881 gctgaatcat attggggttt ctcatatcag ggatcatgtg aaaacgatct gtgccgatgc 269941 agttcaatat gccgctgaaa aaggcctgca gctggcggcg gcacaaggtg ggattcagcc 270001 gggcatggtt gcgatccggg atgagcgggc atcggaaacg gcggggttgc tgaagaagaa 270061 aaaagtgatt tgcgcgccgc gggaaaatgt tatccgtctc gctccccatt tttataatac 270121 gaaggaggaa atgcggcacg cgattgatga aatcgcggcg aaaacgatcc acaagtaaac 270181 atgaaaaagc ccctgaacac tagtcagggg cttttcatat taatgatcta ctttaacgcg 270241 tttcataaag aaagcgccaa ttaaaccgat aatggcaaca atcattgcaa acacaaatgc 270301 gtgctgtacg cctgctgtca aagcttgcgg gatgactgcc ggatcggcag ggtttttaac 270361 tgtactcata taatcatgct ggcctgcagc cataatgctg accgcaaccg ctgttccgat 270421 agcgccggcc atttgctgca gcgtgttcat aatggcggtg ccgtctggat aaaattcacg 270481 cggcagttgg tttaaaccgt ttgtctgtgc aggcatcatg atcatagaaa tcccgatcat 270541 caagcaggtg tgcaggatga taatcagcac agctgttgaa gtggtcgtga catttgagaa 270601 gaaccatagt acaacggtga caatcacaaa tcccggaatg acaagccatt tcggcccgta 270661 tttatcgaac aagcggcctg taacagggga cataaatcca tttaaaatac cgcccggcaa 270721 gagaacaaga ccagatgcaa atgcagtgag gactaagccg ccttgcagat acatcggcag 270781 aagcagcata gatgacagaa tgaccatcat acaaatgaac accatgatca cacccaaaat 270841 aaacatcggg tatttgaacg cacggaggtt catcataggc tgcttcattg tcagctggcg 270901 gattgaaaat aagataaggc cgacaacgcc gacaatcagc gacacgataa cagtcgggct 270961 ggaccatccc ccggagcctt cacccgcgtt gctgaatccg aatacaatgc cgccgaagcc 271021 aatcgtcgac aggatgatag acaatacatc gattttcggc tttgtcgttt cagatacatt 271081 ttgcatatat gcgataccga aaacaagcgc cagcacaagg aatggaagag agatccagaa 271141 aatccagtgc cagttgagat gctccagaac caatcctgag aaagttgggc cgatggcggg 271201 cgcgaacata atgacaagcc cgatcgttcc cattgcggca ccccgtttat gaggcgggaa 271261 aatcaccaag attgtgttaa acatcagcgg cagtaaaaga ccggttccaa gtgcctgaac 271321 gatccttgcc gctaataaaa acgagaagct cggcgcaagc gccgcaatga atgtacctaa 271381 aattgaaaag ataagtgaca cggtaaaaag ctgtcttgtt gtgaaccact gcaacagcag 271441 tcctgaaaca ggaacaagga taccgagtac aagcaggtag cccgtcgtta accattggac 271501 ggttgccgct gtaatgttca attccttcat aaggtcggtt aacgcaatat tcagcgctgt 271561 ttcactgaac atgccgataa aaccggccaa cagcaaggaa atcataatcg gcatcacttt 271621 gtattgctga gatgctttag ctgttgtttc caaaatcatt tcccctctct atcaactgca 271681 tgtagtatgt cgtttttttt atctcttcag caggtcagga atgcagctgg agatatgaag 271741 gagcggcgta ctgttttttg ccgtcaaaga taaaaggatg ccgccttcaa tcatcgcgtt 271801 aaccacagtg ctggcttctt ttgcacggct ctcgctgcag ccagtctgcc gcagtttttc 271861 ctcatacaca gaggcccatt ctttgtaggc ttcatgacag gcttcgcgca acggttcgct 271921 tttcaatgac gtctcagccg ctagcaagcc cacaggcaag ccttcaatgt cttccgtaca 271981 tgaaaactgg caggagagct ccttcaaaaa ggcttgaatg ccttccgctg gatcggtgca 272041 ggcttccatg cagtccgcga ttttctgacg gatatactcc ttcatctcat tcacggcttc 272101 gatcgcaagc tgttctttac ccccgggaaa gtggtagtaa agagagcctt taggcgcgcc 272161 gctttccttt ataatctggt tcagccccgt gccgtaatac ccttgcagct gaaaaagccg 272221 ggtagctgcc gaaaggattt tctcacggga atctccataa ctcataacat tcccacctta 272281 ctgaattgca atcaaaaata tagtgactgg tctattatct tgattcaatc atcaattgtc 272341 aagaaaaatt cattgtatga aaagacaaaa aaagaaggat atgacaacaa aaaatactga 272401 gagaaaagct gactgatctt ttgactgaat agataaaatg tacaatgatt aatcatcata 272461 tggatgtaag gagagaaata gatgaaaaaa caacgaatgc tcgtactttt taccgcacta 272521 ttgtttgttt ttaccggatg ttcacattct cctgaaacaa aagaatcccc gaaagaaaaa 272581 gctcagacac aaaaagtctc ttcggcttct gcctctgaaa aaaaggatct gccaaacatt 272641 agaattttag cgacaggagg cacgatagct ggtgccgatc aatcgaaaac ctcaacaact 272701 gaatataaag caggtgttgt cggcgttgaa tcactgatcg aggcagttcc agaaatgaag 272761 gacattgcaa acgtcagcgg cgagcagatt gttaacgtcg gcagcacaaa tattgataat 272821 aaaatattgc tgaagctggc gaaacgcatc aaccacttgc tcgcttcaga tgatgtagac 272881 ggaatcgtcg tgactcatgg aacagataca ttggaggaaa ccgcttattt tttgaatctt 272941 accgtgaaaa gtgataaacc ggttgttatt gtcggttcga tgagaccttc cacagccatc 273001 agcgctgatg ggccttctaa cctgtacaat gcagtgaaag tggcaggtgc ccctgaggca 273061 aaagggaaag ggacgcttgt tgttcttaac gaccggattg cctcagcccg atatgtcacc 273121 aaaacaaaca caactacaac agatacattt aaatcagaag aaatgggctt cgtcggaaca 273181 attgcagatg atatctattt taataatgag attacccgta agcatacgaa ggacacggat 273241 ttctcggttt ctaatcttga tgagctgccg caggttgaca ttatctatgg ataccaaaat 273301 gacggaagct acctgtttga cgctgctgta aaagccggag caaaggggat tgtatttgcc 273361 ggttctggga acgggtcttt atctgatgca gccgaaaaag gggcggacag cgcagtcaaa 273421 aaaggcgtta cagtggtgcg ctctacccgc acgggaaatg gtgtcgtcac accaaaccaa 273481 gactatgcgg aaaaggactt gctggcatcg aactctttaa acccccaaaa agcacggatg 273541 ttgctgatgc ttgcgcttac caaaacaaat gatcctcaaa aaatccaagc ttatttcaat 273601 gagtattgaa gaaaagaagg cgaataagcc ttcttttttt tggcttttta ggaccaataa 273661 tgacctctga atcttaaaat ttctttaaaa ataagccaaa attacccttt acttaattaa 273721 tttggtaacg taatataatt ggagaatttg ttacaaaaaa aggaggatat tatgaaattt 273781 gtaaaaagaa ggatcattgc acttgtaaca attttgatgc tgtctgttac atcgctgttt 273841 gcgttgcagc cgtcagcaaa agccgctgaa cacaatccag tcgttatggt tcacggtatt 273901 ggaggggcat cattcaattt tgcgggaatt aagagctatc tcgtatctca gggctggtcg 273961 cgggacaagc tgtatgcagt tgatttttgg gacaagacag gcacaaatta taacaatgga 274021 ccggtattat cacgatttgt gcaaaaggtt ttagatgaaa cgggtgcgaa aaaagtggat 274081 attgtcgctc acagcatggg gggcgcgaac acactttact acataaaaaa tctggacggc 274141 ggaaataaag ttgcaaacgt cgtgacgctt ggcggcgcga accgtttgac gacaggcaag 274201 gcgcttccgg gaacagatcc aaatcaaaag attttataca catccattta cagcagtgcc 274261 gatatgattg tcatgaatta cttatcaaga ttagatggtg ctagaaacgt tcaaatccat 274321 ggcgttggac acatcggcct tctgtacagc agccaagtca acagcctgat taaagaaggg 274381 ctgaacggcg ggggccagaa tacgaattaa tgaaaaacaa aaccttgaag aatgctattc 274441 ttcaaggtta ttctgctttc agcacaatgg ttttcgcagc catatcatga acggtttgtt 274501 ttttcttcgt aaatgcggca gtcaaataga tcaggcggga gaacacatgc acccacgcta 274561 tcaggtaacg gacaatggct tgcgggaagg atattttttt atatgtttcg tccctcacga 274621 tttgcagccc gatgattttt ttgcctagtg tgcccttcca atttgtcagc ggcatcagca 274681 aagggtacac aatcagcatc aatatggcga caataatgac accggcggac ccatcgccaa 274741 acgtaaatcc ggctgccaaa atcactgctg cggcaatgat tacatcaagt aaaagagcgc 274801 aggcgcgcag catgaaacca gctagttcca atagaaacac tccttaaaat gttaaataaa 274861 cacctaatga ttgtaaaaaa gaagggccta aagtgggaat aggtgataag ccttaaatca 274921 caaaagttgg tgaaaatgtc ataggtaaat tggcataatc agccagctta tcacattacc 274981 aaattctttt ttagcccgaa accaagccct cagaagttat ttttgttaaa atagaaaagt 275041 tacaacagaa ttcggagggt ttattgtggg aaaagtgaaa cgaaatgccc cttgcccatg 275101 cggcagcggc aagaaatata aaaaatgctg cggaagtaaa gttgtcgact tcccggcgga 275161 actagcggca aaagaagcga aacaaattca ggaagactta gtggagtatg ccttcacagt 275221 acatagagaa agcatttcag gctttatcaa ccagcatgat tttctttctg ctatggacag 275281 acagacgaaa gacatcagcg tatttaactt aggaatctgg ggaatcttct tccacccgct 275341 tgctggtgag aagacaatct tcgaagagta ccttcagaaa aaaggcgatt cgatcactcg 275401 tccgaaaacg cgtgagatcg tagaatcatg gcagagcatg acgcctgctt tattgctgct 275461 gaaggacctg aaggaaggca tcattcactt tgaagatgtc attacggcaa aacaattcga 275521 agtggaaatg gacgccagca atcaagacct tcctccagtg ggaagcctga ttcttggata 275581 cccaatccac gaagcggaaa aagcagaatt cttcatgcag ttcacgatct tcccggtgaa 275641 gagaacagaa gcgctgatca gcaaggtgaa gaaatatgcg gatgccgctg tgaaggacgg 275701 caaaacgccg gaggacttca tgaagcagga attcaacaac gttctgttcg cgttgttagc 275761 tgagaaagat gaagagccac aagcagagaa agcggaagta agcactgttg agtgggcaaa 275821 cgacttggag aaagaaaccg ctgcggctat tgaagaaggc atgagcgggg aagagtatcc 275881 gactgaattg atcccagctg ttattgacat ctggaaaaca ttctgcgaga aaaaatcacc 275941 tgtcatcaga aagccggaag cttttgcggc ggcagttgaa tattatgtaa acgcaatttc 276001 tcttaacggc gcgtccgttt cccaggctaa actggcgaaa aaatacggcg ttagcgcatc 276061 aacgatttcc agccgttaca aagaaattga aagcacgctg caagatgaag cagatcgttt 276121 tgcacaagcg ttatcctcat aatggaaaaa accttgaaaa gccaggcttt tcaaggtttt 276181 tttatttctg aaacggaatt ttgatttcta accggaagat ggggtggcgg taggtaaaat 276241 ccagcctgcc aaaagcgccc ttcaccagtt tttgaatgat atatgtgccc atgccttcat 276301 gagcgccgtt tttcgttgag cggccaaacg attgataaat tgtatcgagc acttttgggt 276361 ccatcccggg agtgctgttt tcacaagtca gtacataaag cccgctgcgc agtgaagtct 276421 ccagtttaat ctctgctttt tctcgggcct ccgccgcgct gtcgagcgca ttttctaata 276481 tgttgccgac caagctgacc tgatcagcag gcgaaaacgg aagggaagaa agcggtgtat 276541 gcatatgcag cgaaacactc acattcgagg cgcgggcttt ttctaaaaaa tcataaagca 276601 cccctgcaac gtacgcgttc tctcctttca aaaaacggtc atattggctg tattgatccg 276661 cccagttttg aatatatgct tgtgtatctg ccttgggctg agctgatttg attgcagtga 276721 tatgtttcat tgtgtcatga ttccggcttc tgacatcaat cagcatttga ttggcgtgct 276781 gttcagcttg agtcagctta tcaatttgat cagaaagcct tgcctgcaaa gcagactgtc 276841 cgatacggag cccttcacac cctgcaaata tcgcgattac acataatacc ggcatgatgt 276901 ctgtgccaat caacaccact cccaccgaca tcacttgaat caccgcaatc cacgcacaaa 276961 gccctgagga acagtgtttc cacacccgct tcgtattcca aatgtacaat cctgcagcag 277021 ctgcgcctaa agcagcggcg agccaagagg cggctgtgct gtgtgaaaaa gcagcagctc 277081 cctgataaca tatgaaacta aataaaatca gataaagaca ttgaaaaagg gtaatcacgt 277141 actaaactcc tcaaaaatag tagttttgaa aataatcaag ctgctgctta gtgatcatcg 277201 cttttttaga cgttccctca aaggaaactg tgaatgaatg cttggtataa gcggaaaaat 277261 gctttatgta atgaatgttg ataataaagg aacgatgcga acgaagaaaa tctttttcgg 277321 gcaggtcgcc tttaatatca tttaatgttt gatacgtttg cacctcttcg gcggttgtca 277381 caatcgtcgt cgaacgtccc gtccgttctg cgaaaataat atccttcttt tgcaggacgt 277441 gcatttcaga cttttgcttt atcaatatac gcccattcaa actcgtttcc gttttctttt 277501 tcaagtaccg gtcgaaggaa gcggccagac ggtcggcata gtacggcttc ataatataat 277561 catggacgtt caggtcaaag gcgtgaaccg cataaccgcc gtggccggta acaaaaatca 277621 catccacatc aagtgaatgg gatttgatca aatcagcaag ctcgtagcca gacatatggg 277681 gcatctcgat atcggcaagc agcagatcaa tgtctccgtt ctttacccgc ctgtaggctt 277741 ccttcgctga atcggtggaa aagacaattt cgacgtcctg cattctggac acgatcgctt 277801 ctaacttctc taaatctact cgataatcat ctacaagtcc gacttttacc attatcattc 277861 ccctagttac atagaatcat ctttattcta tcccatttca cgacataaaa agaactcttc 277921 gcgacaactt tatccaacta atccagcttt tcgtatatag tcattactag aaataaagat 277981 aagggagatt gtgacatgat tacactgacc gattgcagcc gcaggtttca ggataagaaa 278041 aaagtagtca aagcggtgcg agatgtaagc ttaacaattg aaaaaggaga agtcgtcggc 278101 attctcggag aaaacggtgc cggcaaaacg acgatgctga gaatgattgc ttccttgctt 278161 gaaccatcac agggtgtaat cacagtagac ggctttgaca cggtcaagca gccggctgag 278221 gtcaaacaaa gaatcggtgt cttattcgga ggagaaaccg ggctttacga caggatgacc 278281 gctaaagaaa atctccaata cttcggcagg ctgtatgggc tgaaccgcca cgagatcaaa 278341 gcaagaatag aagatttatc gaaacggttc ggcatgcgcg attatatgaa ccggagagtg 278401 ggcgggtttt cgaaaggcat gaggcagaaa gtcgccattg ccagagcgct gattcacgat 278461 ccggacatca ttttatttga tgagccgaca actgggcttg atattacgtc aagcaacatc 278521 ttccgcgaat ttatacagca gctgaaaaga gaacaaaaaa cgattctttt ctccagccac 278581 attatggagg aagtgcaggc gctctgtgac agtgtcatca tgattcacag cggagaggtg 278641 atttaccgag gggcgcttga atcactatac gagagcgagc gcagtgagga tttgaattac 278701 atctttatgt ctaagcttgt cagggggatt tcttaaatgc tgagccatat ttataaaaaa 278761 gaaatgatcg acgctttacg cgacagaaaa acgatattac tcacaatctt agtgccgatg 278821 attatgatgc ttggacttgt ctttttttat gaaagcatgc tgtccgacaa aggggagcag 278881 tacacgctgg ctgtcggcca ttcgcttccg cccgcactgg aaagcaagct taatgagatt 278941 gacgaaatca gcgtaaaaac atttgcaaag cctgaagagg cagttgatga aggaaaagca 279001 gatgcctatc tgaacgtccc gaaagagttc gactcatatg tcaacagcat gacacctttt 279061 aaggttgatg tttacggcaa ttcaatcgat caagggtcgt caaatgccat gcagcttgtg 279121 cagtctgcct tagatcagta caaaaatgaa attgtgcagc aacgtttaac aaataagcat 279181 attgatcaat cggtgatcca gccgtttaca attcagcaaa aggaagcgga tgaggagaaa 279241 gggacttccg ctattatgct ttccgccatt ctgcccatgc tgattctgac ttccattgtt 279301 tccggcgcaa tgccgatcgc tcttgatatc atggccggtg aaaaggaccg aaagtcaatc 279361 gaggcgctgc tattaacgcc agtcagcaga aacaaagtgc tggtcggcaa gtggcttgcg 279421 gtttccactt ttggcgtggc ttcaggtgta tttgctttgg tgtttttgat tttgtccacc 279481 gtgttattta ccgaaaattt aaaaacggcc ttccagctgg gagatcatat gtggagtgta 279541 atcggcgctt cagccttaat cattgtgctc tctgcattgc tgatatctgc gatggagctt 279601 ttcatcagca tcatgtccag ctcggtaaaa gaagcgcaaa gttatatgtc tctcgtcgtc 279661 tttctgcctg tgttcccgat gtttttcatc ttcagcaagg caccgaacca atttgactta 279721 tcatactttc tcatcccgtt tctgaacctg catgcgttat ttaaacagct tttattcggg 279781 atggttgacc cggctaccat tttgtctacg tcaggaacca tcgccgtgct catcgccatc 279841 ttctttttac tagccagagc ctgcttcctg aaagacaaat gggttcttcc aaaataaact 279901 tgcgaaagga gaaatacact ttctcctttt tgtatatcct gaaaaaagaa ggaaaataga 279961 aaaaggatat ctaatacaaa aagtgaccct gcactatttt tcatcaaaat tggtttcaaa 280021 ggagaaggaa caatggatca aacacgtaca ctcggcaaaa cgaagctgaa ggtgaagcgg 280081 atcggattcg gcgcgaatgc ggtcggcggg cataatctat ttccaaatct aaatgatgaa 280141 acagggaagg atttagtgcg cacggcattg gatggcggcg tcaattttat cgataccgcc 280201 tttatatatg gattggggcg atctgaagaa ttaatcggcg aagtcgtaca ggaacgcggc 280261 gtgcggaatg agctcatcat cgccaccaaa ggagctcata aagaagtgga cggcagcatt 280321 gaattagaca atagccggga gtttcttcgc agcgaggtgg agaagagcct gaagcggctg 280381 aaaacagatt acattgattt gtattatgtt cactttccgg atggaaaaac acctctcgct 280441 gaagtggcgg gcactttgaa agagctgaag gatgagggga aaatcaaagc gatcggcgct 280501 tcgaacctcg attatcagca attgcaggat tttaatgctg acggctattt ggaggtcttc 280561 caggccgaat attctctcat acagcgtgat gccgagaaag agcttcttcc atactgtgaa 280621 aaacaaggca tctcctttat tccttacttt ccgcttgcgt ccggactgct gacaggaaaa 280681 ttcacgcaag acacagtctt tgatgatttc agaaaggata aacctcaatt tcagggtgaa 280741 acgtttatcc acaatctcaa aaaagtagat aagctgaaag cagtagcgga ggaaaaacaa 280801 gcggatacgg cacatgtcgc cttggcgtgg ctgttaacga gaccggcgat tgatgccatt 280861 attccaggag ctaaacgacc ggagcaatta caggataacc tgaaaacctt gaacattgaa 280921 ctgaccgaag atgaagtgaa tttcatcagc gacattttca aataaaaaag gaaatagccg 280981 tcatggctat ttccttttgg tgttttattc tttgatgaat gcttcgacta attctgctgc 281041 tctgtaatca tccatatcaa gctgccattg gtcgatgtca tttttcttca ttttcacttc 281101 aactgttttt tcagatgaag caggtccaag ctttttgaat tcctcaggat agacttgaag 281161 cgcgtatttc actgcctctt catagctggc actagagttt ttactgtagt agtctttcac 281221 tttgtcttcg atgcggtctg aaagagaaga tgcatctaca ggtttaactg tggcttcaac 281281 aattgcttcg tctttagaga ttgaagtcgt ttttgcttga atggaagagt ttttgcttaa 281341 tccctcttta atgccgttca cgatattatc aagcgctttg ctgtccgcat atgtgctgga 281401 aaggccggaa gctgagagat aaccgtcttt ggctgattca ttaaaatcat ttacaatttc 281461 atttttgtta gcgccggtga ttttttcgaa atcggcgtta tctttgccga aaagaaggac 281521 atcaacataa gctgataacg cttttgcaga atcttggagc ttatctgccg tcgccaggat 281581 ttttttgtct tttccgtcaa ttttaaaagt aactgatttt ggctttttat caccgtaaga 281641 ttccggcgta tagttaagct cgtattgctt gcctttatct acaacgaaga aaagatttcc 281701 ttcaacggat ttgtcagcgt taatcgtgct gccctgaagc ttttcgctat agtcttcagg 281761 gtctgtgtca gacattttgg tatcaccttg atacaatgtg aaatccatac tgtctacatt 281821 cagcgggtct tttcctgtgt ttttcaccgc gacattgact tttaacacaa gctggtcatc 281881 tgaagtggac ttatcatatt tagacggaag tgtgtaagag acatccttga ttttgacttg 281941 agctatatct gagctttttt ctgtttctga ttctttcttc tccgcgcttg ttttgctgcc 282001 ggaacaagca gctgtaaaca tcatcagcag aagaattagg aaaacagcgt acgttttttt 282061 ctgaaacatt catttttcct cctcaaatgg tttaggaaag gggagtcttt tgtctttgag 282121 aaatggatct ttttgaatgg attagcatca tataaccaaa aaaatcagtt cttttctcac 282181 ggttttcacc ggattttctg gaaactccgc cctcctttgt catgaatgga cctataaaaa 282241 gttacaacgg aattaatttt aagattatta gcttttatat tgaataggtt catcatccta 282301 tttttggtga aaaatgttct ggtaaaactg gtaaactcag aaaactgtgt attttagact 282361 attacttttt gattagttgg agggaactta agaaggatga aaggggccgc ctttgtgaag 282421 aaagagggac tgaaacaaaa agcactggaa atcggccggg tgccgacaca cttaaaactg 282481 gaaattgaag attatggcgg tgatgataaa agagctcatt tttgttgggc agatcctcag 282541 gatgagaata ccggcattat cgtggagctt ggaccggacg gagagctgga atccctttcc 282601 cgtgatattg agcctgaaag cggagaaagg ctgtctgagg agaaactaga ggatatcatg 282661 cgccaatttg tcgagactca tcatccgggg gcactctctg cctttgttcg tgaagaaaat 282721 gaccgtgcat acggcgataa agtgagattt tcatatgttc aaatggaggc tgggcttcct 282781 ctccccatga gcggatttat ggctgatgtt tccttatcag gtgagattgt ttacttccgt 282841 tattacggcg aagcgggcag catcatcaag ccaaagcggg tcgcggatgt tgaagaggca 282901 cttgccttta tcaagaagga cgtggagttc gaccttttgt ttgaggttct ccatcgttct 282961 gtttacaaaa acggagatga tcagccgcat ttggtgtacg agcctgaagg tagggcgatt 283021 accgtacctg cggatttggt tcaagaagaa caagcagttg atgatgacga tgattacagg 283081 gagccggaga gctttcctct ccctttattc gagggcatcc gcgaaaaggc cgatcctgac 283141 agcatgattg gtattgaaaa tgggtttgtc aaagagcggg aagcggattt gggagatggg 283201 agaattggaa tcgtttggcg gaatccggat gaccctgtgt atcagccggc ggataaaagc 283261 atggacagct ggtttaaggg acggactcat caagtgctga aaaccatcta taacaaagaa 283321 accggaaaac tcgaaggcgt catgtcattt atggagaaaa aagggccgct gacagtaacc 283381 ttggcagagt gtgaaaaaat cgcgcttcgc tttctatttg ctttatttcc gaatgccgat 283441 caatatttta ggatcagata cgacgaaaaa gatgaagaag aaaacgcagt cgctggtttt 283501 acgtttgaag cgcattgtca cggagttccg ctccgatttg ggcagatcag aatttgtgtc 283561 agccgccaga cagggtatat caccgtttat atgggaccgg atattgaccc aaataagctg 283621 gcaaccattg atcctgtgcc ggctatttca gttgaacaag ccaagtctat cttttggcag 283681 cattttaaag ttgagcttgg ctgggaaaga gagtacgggg atgatgaaga acacagctac 283741 cggctcgtct ataagccggt gtatccgcat tttatcgatg cacatacagg ggagcctgtc 283801 ttcagcatat ggtgaaacag ccaaaagtca cgcaattgcc tcagatatag aagagagtat 283861 gtgatgaaag taacagaaag aatctcaaaa aacaatgaca ataatagaaa aggacctttc 283921 ttcactttaa atgaagaaag gtctttttat ataataaaca ggattctctt tgtcgtagac 283981 tctttgaaag ggatgacttc attggttaat aaacagctga aaaagaaggc gcaggagatc 284041 ggaaatgtac cgacgcatta tgagcttgag atagaagatt acgaccaaaa gcaaaagaag 284101 tacgggcagg catattttat ctggaaggac cctaaagatc cggaaaagca cattacagtt 284161 gaacttagaa atgacggcgc cttgctcacc ttttcaacaa ctgtccactc cgagacagac 284221 aaaaaacttc cagatgccga gctgaagctg acggctcttc agtttgccgc tgccaatcat 284281 cccggcacat ttatgaattt tcattttcaa ggcaaggaag aaagggggca gcacatccgg 284341 tttgtctata ccaaaatgga gctggggctt ccgattccca attcaggctt tttaattgat 284401 atgacacgaa gcggtcagat tgtccacttt ctatattacg gggaagggca taaagccgaa 284461 gttccgacgg aatttgtagc aaaagagaag gttgtatccc attacttaaa cacaatgtct 284521 tttgagctga tgtacgatgt cattgatggc gaacaggaac caaggcttgt atatgaaccg 284581 attctaccgg gatacagcta tcccgcagat gtagacgaaa ttgtgcccga ccagcatatc 284641 gcagatgaaa gaatagaaaa cacggcgcca ctgccgccgc ttcagaacaa ggaagaagtt 284701 gatatatttg ccttgctggg ttttacctct gatatgcaga aagtcagtga aagagacttt 284761 ggagaacaaa ttggaagcac gtggcgcagg ggcgctgcgc cggagcgtaa ggatttaagc 284821 ataggaagct attttgaaac gagaaataaa aatacaatca aaatgaagac ggataaaaga 284881 accggaaaat taaaagcagc gctttctttt atggactggc ggaacaacct ccaatgctcc 284941 acggaagaat gccaagagat agcgcttcaa tttttgtatg ccctctatcc gagagcggct 285001 gagtttttca gggtgaatcc cgtccgaatt gatgaaagag ggagagtccg caaccatttt 285061 tctgtctggt ataaaggagt gccgctgcgg ttcggcgctg cccgcatcat tgtcaatccg 285121 gaaactgggt tgattgacgc ttttatggcg cctgatattg aacctgaaca attggaagcg 285181 ataaatcaca ggccggatgt ttccgctgaa gaagcgaaag aagcattttt agccgctttt 285241 gatgtgaaac tggaatggca gcctgatttt acagcaggca gtgaccagca ctgcaaactt 285301 gtctataagc cggtttaccc ttcctatatt gatgcgcaca taaggaaaaa gaaaaggctg 285361 tgaggggtgt ctagttagga atcatctcca agtgggggta gtccttgaat cgtttccaat 285421 ccccgcccca ttcgaaaccg agtgtcttag cgatctcgac aacctccagc caatctgatt 285481 ttccgttttg attgccgtca tattccatat cccatatgat gctgccatcc tttttttgaa 285541 gggcgaaatc aatcgctaaa ccatagttat gatacgattc ccctcctctt gcataggtga 285601 caatattccc tttttttgta cgtccctgtt tatataattc atcttgttcc ttaaaggacc 285661 tgaatccttc agtaatgacg acgtcaatgc ctttattcgc tgcagcggct ttgagtgcat 285721 cggcattctg cttcacaatc ggatgaagat ccgaggggac aggcatgtcc tgcaaggcgt 285781 tttgagaatg ccattcatgc cgaatataac taaaacaaag atctagaaga aatagaatac 285841 ataagataac aaatgttttt gcgggtaagt tcatatcggt ctcactttct caagatgtgc 285901 tgaatgttaa cgcttttaag tgattgactc tctctaaaag cgaacagcta tgataaaata 285961 taacataaat agtagcagga ggaaggaggc agaccgatga gagcaaagat tccatcagaa 286021 gaagtagcag taaagctgaa tgaatggtac aagctcattc gcgcatttga agcagatcaa 286081 gcagaagcgt taaagcagga gattgaatat gatttagaag atatggaaga gaatcaggac 286141 ttgcttttat atttttcttt gatggaattc cggcatcgaa tcatgcttga taagctgatg 286201 ccggtgaaag acagcgatac caagcctccg ttctctgata tgctgaacga aattgaaagc 286261 aatcagcaaa aactcacggg cttactggaa tactactttt attatttcag aggaatgtac 286321 gaattcaagc agaaaaattt catattagcg attgaccatt ataaacatgc cgaggaaaag 286381 ctcgagtatg tcgaggatga gatcgaaaaa gctgagtttc tttttaaagt cgcagaagtg 286441 tattatcaca tcaaacaaac gtatttttcc atgaattatg cgagccaggc gcttgatatc 286501 tatacgaaat atgaactgta cggtcgccgc cgggttcagt gtgaatttat catcgccgga 286561 aatttgaccg atgtgtatca tcatgaaaaa gcactgaccc acttgtgcag cgctttagaa 286621 catgccaggc agcttgaaga agcgtacatg atcgctgctg cctattataa tgtcggacac 286681 tgtaagtaca gtctgggtga ttacaaagaa gcggagggct atttcaaaac agccgccgcc 286741 atttttgagg agcacaactt tcagcaagct gttcaagctg tattttcact gacccatatc 286801 tactgtaaag agggaaaata cgacaaggca gtagaggctt atgaccgcgg gataaagagc 286861 gcggctgaat gggaggatga catgtacttg acgaaattcc gcctcattca tgagctgtat 286921 cttggaagcg gcgacctgaa cgtgcttaca gaatgctttg acctgctgga atccaggcag 286981 cttcttgctg acgccgaaga tctgctgcat gatacagcgg aacgtttcaa tcagttggaa 287041 cattacgagt ccgccgcttt cttttaccgc aggctgatga atattaaaaa gaagcttgcc 287101 gagcagcgtt ttcaatagga aatggcagag aactacaggt tctctgcttt ttttgtgctg 287161 ttttcaactc ggaaaaacag ggtattttcc actgcatagt gagaaacaga ggaggatatc 287221 aagtatgtac aaagatttaa ccggaaaaac agcgattgtg acagggtctt caaaaggaat 287281 cgggaaagcc attgcggaac ggttcggaaa ggagaaaatg aatgttgttg taaattacca 287341 cagcgacccg tctggagcag atgaaactct ggaaatcatt aagcagaacg gagggaaagc 287401 cgtctcagtt gaggcggacg tgtcaaaaga agaggggatt caggcgctct tggacacagc 287461 tttagagcat ttcggcacgc tcgatgtgat ggtaaacaac tccggtttta acggcgttga 287521 ggcgatgccg catgagatga gtcttgaaga ttggcagaga gtgattgatg tcaatgttac 287581 cggaaccttt ctgggagcga aagcagcact taaccacatg atgaaaaaca atatcaaggg 287641 caatgtgctg aatatctcaa gtgttcatca gcagattccg cgccctgtaa acgttcagta 287701 ttccacatcc aaaggcggca tcaagatgat gacggaaacg ctggcgctca attatgcgga 287761 taagggaatc cgcgtcaatg cgatagcgcc cggcaccatt gccacagaat caaatgttga 287821 tacgaaaaag gaagagagca ggcaaaaaca attgaaaaaa atcccgatga aagccttcgg 287881 aaagcctgaa gaagtggcgg cagcagcagc ttggctcgta tctgaggaag caagctatgt 287941 gaccggcgca acacttttcg tcgacggcgg aatgacactt tatccatctc agcttgaata 288001 gaagacaaaa cagggggatt gcgggatgaa aacagactgg tggaaggatg cagtggtgta 288061 ccaaatttac ccgagaagct ttcaggacag caatggagac ggaattgggg acttgcgggg 288121 gattatttcc cgtcttgact acataaagga gctcggggca gatgtgattt ggatttgccc 288181 gatctatcct tctccgaatg ttgattacgg ctatgatgtg acaaaccata aggcgattat 288241 ggattcttac ggaacaatgg acgattttca cgagctgctg gaccaggtgc atcagcgggg 288301 attaaagctg gtgatggact ttgtgttaaa tcacacctcg gtcgagcatc cgtggtttaa 288361 agaagcggag ctggacaaaa acagcaaata ccgtagctat tattattggc gtcccggcac 288421 aaagaacggc ccgccgacgg actggctctc aaactatgga tgcccggtct ggcaatacga 288481 agagcacacc ggagaatact atctccatat gaatgccgtc aaacaagctg atttaaactg 288541 ggaaaatccc gaagttcgcc aggcggtgta tgacatgatg aaattttggc tcgataaagg 288601 ggtcgacggt ttgcgaattg atcagctcca tctcatttct aagaaagaat atcttccttc 288661 gtatgaggac tatatcaatc agcaggcaga gccgaagccc tttcagccaa atggcgaacg 288721 aatccatgac tatttaaaag aaatcacaga tgaagtgttt tctcattatg atgtcatgtc 288781 tgtcggagag gtcggcagtg tcacaccgga agaaggcctg aaatatacgg gaacagataa 288841 gcatgagctg aatatgattt ttcactttca gcatatggag cttgatcagc agcccggaaa 288901 agaacattgg gatttgaagc cccttgagct ttctgattta aaatcggttt tgacaaaatg 288961 gcaaaagaag cttgaacatc aaggctggaa tacattgttt tggtgcaacc acgaccagcc 289021 ccggattgtg tccagattcg gagacgatgg ggaataccgc aaagcatcag cgaaaatgct 289081 ggcagccgta atttatttta tgaagggcac gccgtatatt tatcagggag aagaaatcgg 289141 gatgacaaac gcgccgttca cccggattga agactacaaa gatatccaaa cgatcaatat 289201 gtatcataaa cgggtgtttg aaaaaggcta tgatccaaat gatgtgatga gatcgatctt 289261 agccaaaagc cgggatcacg cccggacccc gatgcagtgg aacagcggca aaaatgccgg 289321 atttactgac ggcacgcctt ggctgaaggt caatccgaac ttcaccgcaa tcaatgtgga 289381 ggaagcgcag ggagatcctg attctgtctt aaactattac aaaaagctga tcagcctgag 289441 aaagcagtac gctgacctca tgaaagggag ctttgatctt ttgcttccgg acgatccgca 289501 gttgtttgta tacatgagag aaaacagtaa acaacagctt ttgtcggtca ataatttttc 289561 aaaagagcag gctgtttttc agtggcctaa gaactgcggc aaagctcagg cctcactgct 289621 tctcagcaat tataacaacg atgatcttga tgacgaaatg gtgttccggc cttatgagag 289681 cagggtctat cttctggaca aaacaaacta atgattgaag tagcccggca tttttagccg 289741 ggttttttta gtacatatat tcgctctgca ggcgggaaga ataaatgaaa atgaaattta 289801 ttcttgcaaa acgtaatgac ttcggtttat tatgatatag gattacaaaa tcgttatcat 289861 tttgatttaa agttactgaa aaagagggga tatacgatat gtttaaaaaa tggagcggtt 289921 tgtttgtgat tgcagcgtgc tttttattag ttgcagcatg cggcaactca tcaacaaaag 289981 ggtcggcgga ttcaaagggt gataaactgc acgttgtcac aacgttctac ccgatgtatg 290041 aattcacaaa acaaattgta aaagacaaag gcgatgtgga tctgttaatc ccatcttccg 290101 ttgaaccgca tgattgggaa ccgacgccga aagacattgc caacattcag gatgctgatt 290161 tgttcgttta taatagtgaa tacatggaga catgggttcc gtcagctgaa aaaagcatgg 290221 gccaaggcca tgccgttttc gttaatgcaa gcaaaggcat tgatttaatg gaaggctctg 290281 aagaagaaca cgaagagcat gatcatgggg agcatgagca cagtcatgca atggaccctc 290341 acgtatggct tagccctgtt ctggcacaga aggaagttaa aaatattacg gctcaaatcg 290401 tgaagcagga cccggataac aaagaatact atgagaaaaa tagtaaagaa tatattgcaa 290461 aactgcagga tcttgataaa ctatatcgta caaccgcaaa aaaagcggag aaaaaagaat 290521 ttatcacgca gcatacagct tttggctatc tggcaaaaga atacggcttg aagcaggttc 290581 cgattgcagg gctttcacct gaccaagaac cgagcgcagc cagcttggca aagctgaaaa 290641 catatgccaa agaacataat gtaaaagtta tttactttga agaaattgca tcctcaaagg 290701 tcgcagatac gctcgccagt gaaatcggcg cgaagacaga agtgctgaat acactggaag 290761 gcttgagcaa agaagaacag gataaaggtt tagggtatat cgacattatg aaacaaaacc 290821 tcgatgccct gaaagattca ctattggtta aatcataaga tagtgtgcgc cggaggggtg 290881 cacactattt ctttgtgaga aaggaagatt aacatgaatc tcgtctcatt gaaagatatc 290941 gttttcggct attcccatac gcctgtttta gataaagtat cacttgatat tgaaagcggt 291001 gagttcgtcg gcatcactgg accaaacggc gcctctaaat cgacgctcat aaaggtaatg 291061 ctcggcatgc tgaaaccgtg ggaaggcaca gtgacgatca gtaaaaggaa tacagaaggg 291121 aaacgcctga ccatagggta cgtcccgcag caaatttctt catttaatgc cggatttccg 291181 agcacggtgc tggagcttgt tcagtcaggc cgctatacaa aagggaaatg gtttaaacgt 291241 ttaaatgaag aagatcatct tgaagtagaa aaagcattga aaatggtgga aatgtgggac 291301 ctccgccatc gtaaaatcgg tgatttatca ggcggacaga aacagaaaat ctgtatcgcc 291361 agaatgctcg ccagcaaccc ggatctgctg atgctggacg aaccgacgac agctgttgat 291421 tacgacagca gaaaaggatt ttacgaattt atgcatcatc tcgtgaaaaa tcacaaccgc 291481 acagttgtga tggttactca cgaacaaaac gaagtacagc aatttttaga taaagtgatt 291541 cgattagaga gaggagaaaa aggcggatgg aaatgtttga cttggaattc atgcgacgag 291601 cttttctagc aggcggcatg atcgccgtca tggctccgat actaggagtg tatctcgttc 291661 tcagaagaca ggccttaatg gctgacacac tttcacatat ctcattgtca ggtgttgcca 291721 tcggcttttt tctcagcacc aatataaccg cagcaagcat agtcgtcgtg accatcggcg 291781 cgatcggaat tgaatacatg cggcgggcgt atcggactta ttcagaagtg tccattgcca 291841 tcttaatggc agctggtttg tccttcgcga tgtttttaat cagcctttcc aaaggcacag 291901 ccaatatgag catcgatcaa tacctatttg gatcgcttgt gacagtaaac cagcagcagg 291961 tctatattat cagtattatc acactgctga tcctgcttta ttttattgta ctgagaaggc 292021 cgctctacct gctgacgttt gatgaagcta cagccaaaac atcgggaatc aatacaaacg 292081 ttctctcgtt gtcattcagt attgtcacag gccttgcgat ttcagtcatt attccgatca 292141 tcggggtcct tcttgtatcg gccctgctcg tattgccggc agccttcgcc atcagaattg 292201 caaaaggctt taacatggtt ttcattacag ccatactcat ttcattattc agcgtattta 292261 cgggactgac atcatcctat cagctcggga cgccgccagg tccgtctatt accctgctat 292321 tgatcgtttt gctattaatc ggatttgcag ttcagggagt ttggacgttt atcaaaaaag 292381 aagctcagcg caaaaaaaga agccgataac atgaaaagca gttttcccta gggaaaactg 292441 ctttttttat agaaacaatt cggcaaggcg ctcataagat tcttttttcg cctcaaaatc 292501 aaacacattg cacagaacca tgatttcatt tgtttcgtag cagcctgtga ggtctaacag 292561 ctgttgtttg acagtggtgg gagaaccgat caccatccgc tttctgtttt cttctatgag 292621 ttttttatcg gacgctgtat agggatgagc tttcgcttcc tcgatgcttg gcacgcggct 292681 gtccaagcct tttccgacgc gaagaagcca cagatcctgg cttaatgcga gttcttctgc 292741 ctcttcatct gtttttgcgc aaatgacaaa aatcgtaaac agtgcggatg gattcgaaaa 292801 atgggctgag ggccgaaagc tttcccggta gatgcggaat gcattttctc ctcgctcggg 292861 attaatgaaa tgcccaaata catatccaat cccctggtgc gccgcgcgtc ttgcgctgtt 292921 ttcaccaaga ccgagcaccc atagctcggg tgccgtacca ataaggggcg ccgctttgat 292981 tccggcatac ggatggtcgg gaggaaggga atctgttaga aaataagaga catcctgcag 293041 ctgtctgtta aattcggtta agcttttttt caccccgtcc gttaatgcaa gtctggtttt 293101 tgtcgtgccg ccgggggagc gaccgacgcc gaggtcaatc cggtttggat acagggcctc 293161 aagctggcga aaggtttcag ccactttaaa tgggctgtat tggggcagaa gcacgccgcc 293221 tgatccgaca cgaatggtgt ttgtctgtgc tgcgatgcgg gcgatcatga tttcaggcgc 293281 tgtgcttgcc agtcctttcg tgctgtgatg ctcggcaaac caataacgct tatagcccca 293341 ctgttcgctt aattgggcaa gctcaaccga atgctggaga gttgtcacag ggctttctcc 293401 tttagaaaca ggtgcctgat caagtatgct taaatgaatc aaaaggccgc ttcctttctg 293461 tctgttttta gatggtgaca ccagaatagg caaaatgact tgcccgcgtc aaatggtttg 293521 tttaagaagc gcactttata gcatttgcaa atcatatatc aaatatggaa gttttttttc 293581 gaggtttttc gtcaattatt cttaactttt acgaaacttt gatataataa caaacgtata 293641 tattagtaat ttacggctta ttttccttgt gagcgtaaaa ataaatgtga ctatcttcac 293701 attttgatga gtaggagtga atcgtgtggc aatttcttta gaaaaaggtc aacgaattga 293761 tttaacaaaa ggaaaagccg gtctgtcaaa attgatggtc ggtctcggct gggacccagt 293821 gtcctcaggc ggaggattct tcagcaaact gcttggcgga ggcggtccga atatcgactg 293881 tgacgcttca gtgctgatgc tggaaaacgg aaaattcacc gataagaaaa acctgattta 293941 tttcggcaac ctgaaaagcc gctgcggcgg tgtacagcat acaggcgaca acctgacggg 294001 tgacggtgcg ggcgatgacg agcaaattat gatagattta gataaagtgc ctggaaacat 294061 cgataagctt gtatttgtag tgaacattta cgattgtgtc agaagaaaac aagatttcgg 294121 catgattcaa aatgcgttta tccgcgtagt tgatcaatct aatcacgagg aaatgctcaa 294181 gtacaatttg agagacaatt acgccggcag aacaagcctg attacagcag aaatctaccg 294241 cagcggcagt gagtggaagt ttgcggcggt cggtgaaggc acaaacgata cgagattaga 294301 agatattatc agtcgatacg tataaaagaa aaggagtgga tgaaacatga caatttcatt 294361 ggcaaaagga caaaaagtag atttaacaaa aacaaatccg ggtctttcaa aggttgttgt 294421 cggtttaggc tgggatacga acaagtatga cggcgggcac gactttgatc ttgactcaag 294481 tgtgtttctg ttagacgccg cgggcaaatg cgcgtcacca aacgacttta ttttctacaa 294541 ccagcttgaa ggcggcaacg gttcagtcgt tcattcaggc gacaacctga ctggtgctgg 294601 cgaaggcgac gatgagaatg taaaagtaaa tctcagcgct gtaccggcaa acattgataa 294661 aatctcattt gttattacca ttcacgatgc agaagcgcgc agccaaaact ttggacaagt 294721 atcaaacgcg tttgtccgca tcgtaaatga agaaacaaat gaagagctca tccgttacga 294781 tcttgcagaa gatttctcta ttgaaacggc aatcattgca ggggagcttt acagacataa 294841 cggcgagtgg aaattctcag caatcggctc aggctaccaa ggcggccttg cccgcattgc 294901 aacagactac ggtttgcaag tcggttaaga caaatacgaa gagcagaaag gagagaggca 294961 gtatggccat tcaattatca aaaggacagc gcattgattt aacaaaaaca aatccgggac 295021 tgactaaagc ggtgatcggc ttaggctggg atacaaacaa gtactccggc ggacacgatt 295081 ttgacctgga tgcttcggcc tttttagttg atgcgcatga taactgcgta aatgatctcg 295141 atttcgtctt ctataataac cttgaacatc cgagcggcgg tgtcatccat acgggtgaca 295201 accgcacggg tgagggcgac ggagatgatg agcagattat cgttgatttc tcaaaaatcc 295261 ctgctcacat tgagaaaatc ggcatcacag tgaccattca cgacgctgaa gcacgcagcc 295321 aaaactttgg acaagtttcc aatgcatttg tccgcgttgt ggatgaagaa acgcagaatg 295381 agcttcttcg cttcgatttg ggagaagact tctccattga aacagctgtt gtcgtttgtg 295441 agctttacag acacggcggc gagtggaaat tcaatgcaat cggcagcgga ttttccggcg 295501 ggctggctgc attgtgccgg aattacggtt tgcaagtgta agcgagtgac aaatagagaa 295561 gtcaccgttt caaattatag gaggaaaaaa cttggacttt ttacatcata ttttgtctac 295621 gtatgcttca tttttcgatt ggaaaatgtg gggggaagtt ctgactgatc ctgtttcctg 295681 gggtttgatc ggttcccttg ttgttctgga aggcctttta tcggccgata acgcgcttgt 295741 tcttgcggtc atggttaaac acctgccgga aaaacagcgg aaaaaagcgt taacgtatgg 295801 tttgtttgga gcttatattt tcaggtttat tttcatcggg ctcggtatgc ttctcattaa 295861 attctggtgg atcaaggtgc ttggcgcgct ttacctggct tggctcgtca ttaagcactt 295921 ctggataggc gaaaaagaag aggaagcgga cggcatgaag aaaaactctt ggatggtccg 295981 cacgttcggg atcttctggg cgactgtcat ttcagtagaa ttaatggatc ttgccttctc 296041 tgtggacagc atcctggccg cgtttgcagt atctgaaaaa gtatgggtgc ttctgattgg 296101 cggtatgctt ggtattttaa tgatgcgtac agtggcaaaa gtgttccttg tgctgattga 296161 taaaattcct gagctggaaa acacagcatt cgtcttaatc ggcattatcg cgctgaaaat 296221 ggcggggagc gctttccatt acgaaatgcc gcactctgta ttcttcatta tcattatcgc 296281 tgcatttgcg gtaacattga tcattcacta catcaataaa caaaagcagg tgcgcgaaca 296341 aacagccgct tcaaaagaag aataaaacaa aacaaggagg gaggttcaat gtccttcctt 296401 ttttgttacc gaaatatcgt ttcaatgaca aaccggaaag gaggatatga tgagacaaga 296461 agaactaacc attcataaag cacttccggc tgatggcgat tggaaaagcc tgctgtttca 296521 gccattgccg gagcgggatc actatgaaac tgcacaaggc ctttcttttt ctcgtcttgc 296581 cggtcagata ttgggcacgc ctattgatga gacggactac tataacgagc tgtatgagct 296641 gtctgtaaac gaccgcataa cgattttgag tgaaacgctt gataaaacaa tcgaaccgga 296701 aacatttcaa aagcttcagc atattcattc catcaatcag aaagaaaaag ggctgtcagt 296761 cagccgcttt gttgcctttc tggacgggga aaagctgatt gcgaagcact caaatccctt 296821 gatgcaccgc catttaagaa aagcgttgat gacgctttta catacctttg cggacagtca 296881 tgaaaagggg ctgaatcatc ctgattttcg cagagtgctg cttgatgtct cgaagttttc 296941 cttaaaccat ctgaaccctt ggctggaaaa aaccgatata gagcgggaga tgccgaaggt 297001 tgtttggtat ggagatgcga cgaaaagcca gctctatttc ttatattatc tgatgctggt 297061 cggctgtgat gtactgctgt tccatccggc gggaacggat cagctggcgc ttgtcgaccc 297121 gaagcaggag ctcggtttta cggaaaagct cccggatgtt tcggagcttc agccgtttcc 297181 gaaagaaaaa ccagaccgga aatcaacagt ggcttaccgc tcaacaaagg aaattgaaca 297241 tgtgctgaat cacgaggaat ccatgctata taagccgtgg cagttcagag atcacacacc 297301 ggtgtccgtt acgctgaaaa cgacctatga tgaattgttt ttaatcacga aagaacgcgc 297361 ctttattcgg ccgaatttca aagctgataa acattccatt gagattccga atgtattcgc 297421 caaaattatg ggcgtgtcga aagacaataa ggaatattgg aacaggcttc atactctagc 297481 ggattatcag gaaacagaaa tggtcagaag ctttccattt acagaagaaa taaagtcgaa 297541 ctatcaattt cactacagcc acgcacttga tcaagaaggg aacattgatc cggacaagct 297601 gatggcaagc aatgtgtggc agtacaaaca gctgccggcg ggcgttcaga ctgccattgc 297661 caaaacgatt tcgagaatgt gcaggtaccc gcggcttaaa gccttgcatc aggaacaagt 297721 caaggatgtt caaatctatt tgtttaaaca aacaacaaac ctgcctgcta atctgctgaa 297781 attgattcaa atgttcgact atgcgcaaac cgttccgaaa ctcgttttat atcatacgga 297841 aatgagcggc ggactcacgc gttcggatgc tgccgccctg ctgttcctga atgaaatcgg 297901 aatcgatatc atcatttata atccgcccgg acaccaagat attgagcagt ttattgaaga 297961 ggatcagtat gatatccact ggctggatga catggtgttt cagcaggact acaaagagcc 298021 ttcgcttgtg aaaaggctct tcagaaccat tacccaaaaa taaggagaga agaaaagcat 298081 gacaacagaa aatcaaaatc cgcttgttct cgataaaaat gaagagattt cccagcaaaa 298141 agctgacgat atccgtcttc agctccgtca ggaaccagaa gtgaagcggc ttgctcaaca 298201 aattgacgtc aaaaaccaaa tggagctgct tgagtacggc aaggagccgg ccgttgaaat 298261 atccaagttc tctgaccgca tcttggggat gatgaaaaca acaagcgtga cagactccgg 298321 cacaatgctg actcagcttg ggaaaatcat ggaccgcttc gacaaaaatg attttgatga 298381 gccaaaggga ttaatggcga aaattttcaa acgcggcggc agcatgattg aaaaaatctt 298441 taaaaagtat cagacgcttg gcggagagat tgaaaaaatc cacgttgaga tttcaaaata 298501 caaagatgag atgacgaaga cgaactacac gctcgatgaa atgtatgaaa acaatatcaa 298561 atactatatg gagcttgaaa aatacgtcgt tgccgggcag atgaaactgg aagagatgca 298621 gtcgatcctt ccttcatatg aggaaaaagc ggcaagcggg aaccagctgg cgcaaatgca 298681 gctcgatacg ttgcgcaacg gcattcaggc gcttgaggaa cgggtgtatg atcttgacat 298741 ggcacggatg gtggcgcttc aaaccgcacc tcaaatccgt ctcctgcagc gaggaaatgc 298801 aaagctgatc gggaaaatca actccgcgtt tatcattacc attccgattt tcaaaaacgg 298861 cattattcag gctgttacgg taaagcggca aaagcttgtg gctgattcca tgagcgagct 298921 tgaccgccgg acaaacgaga tgctgaaacg aaatgctgaa aacatctcga gccaaagtgt 298981 tgaaattgcg agaatggccg gcagaccgag catagatatt gaaacgattg aatcgtcttg 299041 gaacacgatt gtcagcggca tgcaggaaac aaaacaaatc gaagaagaaa acaagcgcct 299101 ccgcgaagac ggcgcgagac gaattgccca gcttcaggat aatattaaaa aagcagcatt 299161 gcagcaataa taaaaacccc gcttgtggaa cataagcggg gtatttcaat tacatcattt 299221 agttaatgac aatgtgtaaa gacaggtgta aacttaaacg gtaatcattt tgcatatcag 299281 aggtgttggc aatgggaaaa caacagccta tatcccagcg taaactgctg ggcgtcgccg 299341 gtttggggtg gctgtttgat gcaatggatg tcggaatatt atcgtttatt atcgccgcgc 299401 tccatgtaga gtggaatctg tcgcccgaag aaatgaaatg gatcggaagc gtcaattcca 299461 tcggcatggc tgcgggtgcg tttttgtttg gtttgcttgc tgatcgaatc ggccgcaaaa 299521 aagtgttcat catcaccctt ttatgctttt ccatcggaag cggcatttcc gcttttgtga 299581 cgagcttatc ggcatttcta atccttcgtt tcgtgattgg tatgggactt ggcggcgagc 299641 ttccagtcgc ttcaacactc gtttcggaag cggttgtgcc tgaaaagcgg ggcagagtga 299701 ttgtgctttt ggaaagcttt tgggccgtgg gctggctcgc agcggccttg atttcttact 299761 ttgtgatacc aagcttcggc tggcaggctg cccttctgtt aactgcgctg actgcttttt 299821 atgcgctgta cctgcggacg agtctacctg attcgccgaa atatgaatcg ctttctgcca 299881 aaaagaggtc gatgtgggag aatgtaaaaa gcgtctgggc aagacagtat atacggccga 299941 cggtgatgct gtcgatcgtt tggttctgtg tggtgttttc ttattacggc atgttcctat 300001 ggctcccgag tgtcatgctg ctgaaaggct tcagcatgat tcaaagcttt gaatatgtcc 300061 tgctgatgac gcttgctcag ctacctggct atttctctgc cgcatggctg attgaaaaag 300121 cgggccggaa gtggatactc gtcgtttact tgattggcac agcaggaagc gcctatttct 300181 tcggaacggc ggattcctta agtcttctgc ttacggctgg agtgctgtta tcgtttttca 300241 atctcggtgc gtggggcgtg ctgtatgctt ataccccgga gcaatacccg actgcgattc 300301 gagcaacagg ttcaggaacg acagcagcgt ttggaagaat cggcggcatc ttcgggcctt 300361 tgctcgtcgg aaccctggca gcccgtcata tttcgttttc ggtcatcttt tcaatctttt 300421 gcattgcaat cttacttgcg gttgcttgta ttttgattat ggggaaagaa acgaaacaaa 300481 ctgagctaga ataggaaaag cacctcttaa aagaggtgct ttcagcgtgt cgacaaaccc 300541 tcgcattcgt tgtcaggact gcgcttcggt gctcaatgcg aagtggatca acggctaaat 300601 tctcaggcgt cctgcctaaa cgccgtcgtc atcacatcct gtgaatgtcc gctcctatgc 300661 tcgtccttcc tagacttcaa gggttttcaa tcacgctgaa aagattttgt caacaatctg 300721 aggcacctct tgaatgaggt gcttttttac aattgcgccc gggctgtgga ttggcgtttc 300781 ccggttttac tgattgtctg gtagagcgtc atagaaagta tgaacagaat ggcagtaaat 300841 cctgtgacag ctccgaaatg ctgtgtgctt tgatataaaa aacctgcaat acttgtaccg 300901 acagtggttc cggcatacat agcggcattg gaaagggaag cgatggttcc tcgcgcattt 300961 ggtgcaatgg attgaaagac acccatcatt aacggaaaga tgatgccagc tgtaaagaac 301021 gtgagaaaaa agccggcttc tactaaaaac aagtttggaa agaacggaag agcgaaatag 301081 agagcgccca ttagcagcat cccgctgatc agtgttttaa acatgcccag cttttctgaa 301141 acccggctgc cgataaggct cccgagcata tttcccagtc cgagtacaag catagctgcg 301201 ccaatttgtg acacggttaa atgataatcc gcggaaagcc aagtacccag aaagctgaac 301261 gatgcgaagt ttccggtttg aaacagaaaa taggcaagca gaatgaccga tgttttcggc 301321 aatgaaaaaa gctcccgata ggggttgaca attgatgggc gcgccaatgg ttcagaaggc 301381 cggatgccag gcatgaccgc cgccaggatc aatagaagaa taagcgagca cgctgacaaa 301441 acgaaaaatg gcgtatgcca tgtaaaggaa gcgagaaacc ctccaatagg aagtccgagc 301501 atttgtgaag cggccaaacc tgctgtcgca atccccatgc cttttatgat ctgagaaggc 301561 tggacaatga ctgggatgga cgcccaaatt tgaggcgtca caaacgcagc gctaacgcct 301621 gcggcaaaac ggaacaggca catggcggca aaagagggag cgatgccgca taaaaatgtg 301681 gatacgataa agcctgcaag tccccacagc atgactgttt tcctgttcag ccggtctgag 301741 attgggcctg caatgaaagc gaagagtgca taaccgagtg cataagcact gaccatccag 301801 cctgacaaat cagtagagac atgaaactga tcctgtaaaa gggggagaag cggcgaaagc 301861 aaaaaggtat ccgtgccaat gacaaacatg acactgaaga aaagccaaat gcgattcaaa 301921 ttttatcact cctattgttt tataacttta aaactatgaa acagatatgt atagagaaaa 301981 ccctttgtta gagggtttcc aaaaagccag gcaggtatgt ttgaaatgtg tcttcacgca 302041 gactgacgta ttttgtccgc gaatctttcc gggttgccgt caatcccgct tcacgcagcg 302101 ttttaaaatg ataagatgcc gtggttttga caatattgca cttttcacct acttcaccgc 302161 agctgagttc ttttccgctg acataaagcg tacgaataat ggcaagcctt gattcatcag 302221 acagtgcttt aaaaatttgc gctctgattt gatcatctga ttgtttcata gtcatgaaac 302281 tataatacat aatgggtgtt gaaaaagcaa cttatttttc cagtaaagga gcaggaagtc 302341 ataagaggaa ggaggaattc aattccaata aaagcgtttt caactaaagg taggagaaaa 302401 atcacccgta aaatacaatc atataggagg attacagagc atttagaagc ataaataaga 302461 tcatgtggtc acatggatgt ttataaagaa atggtacaga ataaaagaga atatgctgtt 302521 tgtgtgggaa gttacataaa tgttacggta ataaagattg cttaatatgg agggaaaata 302581 tgagtgtaga tgagaaacca attaagataa aagtcgagaa agtctctaag atttttggga 302641 aacaaacaaa gaaggcagtt caaatgcttg ccaacggaaa gacaaaaaaa gagatcctga 302701 aagcaaccgg atcaaccgtt ggggttaatc aggcagattt tgaagtatat gatggtgaga 302761 tatttgtcat catgggtcta tcagggagcg gtaaatcaac tttagtacgg atgttaaacc 302821 ggcttattga accgactgcc ggaaatattt acattgatgg tgacatgata acaaatatgt 302881 caaaagacca gctccgggaa gtccgccgga aaaaaatcag catggtcttc caaaagttcg 302941 ctctgtttcc gcacagaacg atacttgaaa acacagaata cggactggag cttcaaggtg 303001 tagacaaaca agagcggcag caaaaagcgc ttgagtctct taagctcgtt ggactggaag 303061 gatttgaaca ccaatatccc gaccagcttt ccggcgggat gcagcagcgt gtcggccttg 303121 cccgcgcgtt gacgaatgac ccggacatcc ttctgatgga cgaagcgttc agtgcgctcg 303181 atccactgat tcgtaaagat atgcaggatg agcttcttga tcttcacgat aatgtcggaa 303241 aaacaattat ctttattacg catgacttgg acgaagcgtt gcggatcggc gacagaattg 303301 tcctaatgaa ggacggcaac atcgttcaaa tcggcacgcc tgaagaaatc ctgatgaatc 303361 catctaacga atatgttgag aaattcgtcg aagatgttga tttgtctaaa gtcctcacag 303421 caggccacat tatgaaacgc gctgaaacag tgcggattga taaagggcct cgcgtagcat 303481 tgacactgat gaaaaacctt ggaatttctt caatttatgc agtggataaa caaaagaaat 303541 tattaggtgt tatctatgcg tctgatgcga aaaaagcggc tgagtctgat ttgtcacttc 303601 aagacatctt gaatacagaa tttacgactg taccagagaa tacgtatctg actgagattt 303661 ttgacgttgt gtccgatgcg aatattccaa ttgcggttgt ggatgagaag caaagaatga 303721 aaggaattgt cgtaagaggc gcgctgattg gcgcacttgc cggcaataac gagtatatca 303781 atgctgaagg cactaacgaa caaacacaag atccttctgc acaggaggtg aaataagatg 303841 gatagactgc ctagaatacc tttagcagat attattgacc gttttgttga ctggattacg 303901 atgacgtttg gcggattctt cgacggaatc gctaacggat tggccgcttt tgtaaatgga 303961 attgtcaccg gtcttggatt tattccatct attttgttaa cgattatttt cgccgcactt 304021 gcgtggtgga tcagtacaag gggaattgcg ttatttacgt tgattggatt cctcctgatc 304081 gattatttag gatattggga cccaatgctg caaacattgg cgcttgtttt gacatctgtg 304141 attatttcga ttgtggtcgg ggttccgatc ggaatttggg cgtctcagaa agaaacggtt 304201 cgccgtattg taacgccaat tcttgattta atgcagacaa tgcctgcttt cgtatatcta 304261 ttgccggcga ttttcttctt taacatcggt gttgtgccgg gtgttgttgc atctgttatc 304321 ttcgcgatgc cgccgacaat ccgcatgact gttctcggta ttaaacaagt gccggcggat 304381 ttgattgaag cgactgaggc attcggttct acaacagctc agcgtttgtt taaagttcag 304441 ctcccgcttg cgacaaaaac gattttggcc gggatcaacc agagcatcat gcttgcgtta 304501 tcaatggttg ttatcgccgc aatggtcggt gcaccgggac ttggttctga agtatacagt 304561 gccgttacac agctgaaaac cggggtcgga gtagaggccg gtatcgccat cgttatcgtt 304621 gccattaccc tggaccgtat tactcaaaat attaaagtga agaagaaaag cagggggaat 304681 gcctgatgct taaaaaaatc ataggcatcg gcgtttccgc catgctggcg ctctcacttg 304741 cggcttgcgg ttcagaaaac gatgaaaatg catccgcagc agaacaagtg aataagacca 304801 tcatcgggat tgaccccggt tcagggatta tgtccctgac tgacaaagcg atgaaggatt 304861 atgacctgaa tgactggaca ttgatttcag cgtcaagtgc tgcgatgacc gctacgctta 304921 aaaagtcata cgaccgtaag aaaccgatta tcattacagg atggacaccg cactggatgt 304981 tctccagata taagctgaaa tatctcgatg atccgaaaca atcttatggc agcgcagagg 305041 aaatccatac gatcacacgc aaaggcttca gcaaagagca gccgaatgcc gcaaagcttc 305101 tgagccagtt taaatggacg caggacgaaa tgggcgaaat catgatcaag gtggaagaag 305161 gcgagaaacc tgccaaagtt gctgctgagt acgtcaataa acacaaggat cagattgccg 305221 aatggacaaa aggcgttcaa aaggtgaagg gagacaaaat caaccttgcc tatgtggcgt 305281 gggacagtga gattgcaagt acaaacgtca taggcaaagt cttagaagac ttgggctatg 305341 aggtaacact tactcaggta gaggctgggc cgatgtggac tgcaattgcg acgggaagtg 305401 cggatgcatc cctttccgca tggctgccga atacccataa agcatacgcc gctaaatata 305461 aaggcaaata tgatgatatt ggcaccagta tgactggtgt gaagatgggg cttgttgttc 305521 ctcaatatat gaaaaatgtc aactcaattg aagatttgaa gaagtaatca aaaaagcagc 305581 ctgtgtcagg ctgctttttt tgcgttaaga agcgttagcg gcagcaagtg attccgcctt 305641 ctgaaatgtt ttgagcacgg cgttcgccaa aatatgaatg ccggtaaaca tcgcatttct 305701 gtcaaaggtc atgtgcggat gatggagccc cggctggagc ccgcagccta gtccgagcat 305761 cgttgttttc agattcggca ccttcacggc gtaaaaatgg aaatcctcgc cgccggtggt 305821 gacaagcggg tcatcaagcc gctcagcccc gatgatttcc gtaatggctt ctgccatgat 305881 cgcttcagct tctttatttt gtgttgccgc aggaaggctg tgttctttgt gcagctcgat 305941 ctttgcgcca aatgcagcgg cggccgcttc acaggctctt tctgtttcgg cgattaatgc 306001 ctccatggct tcattggtct gtgcgcgcaa atcaaggctg aacgatgctt ttcctggaat 306061 gatgttagag ctttcaccgc cggcttgcag ttttgtcatt ttgacggtat gcgggatttg 306121 cgggtcaata tgaatgagtc cgagcttgtg tacaagaaat gccgcaattt caatgctgtt 306181 tttcccgagg tgcggacggg cgccatgagc ctcttccccg atgatcgttc cctcaatgtg 306241 ctggcttgat ccgtgcagaa tagaaggagc gcagcggccg ttctgtgttt cctggatcgg 306301 acggacgtga acgccataca aatagtcgat atcatcaagc acgccttctt ctatcatttt 306361 caaggcgccg ccgccttttt cttctgccgg ctgaaagata aaacggattg tgcccttcgg 306421 aagctcaggt tgttttttta gcagcattaa cgtgcccaat gccattgtca tatgtgaatc 306481 gtgtccgcag gaatggttgg cgcgaaatgt gccgttaacc tcctgccaca gcgcgtcaat 306541 atcagcgcgt accgctacaa caggtgagcc tgagccgatt tcgccgacaa ccccggtgca 306601 gtctgaaaac gtgcgcgtcc ggcaccctaa atcctcaagc ttttgtttca aaaatgaagt 306661 tgtctcatat tccttccagc tgacttcagg gttcgcgtgc agatgctcga agatgtccat 306721 aatggtttgt ttcatttctt ctgaaagctt ttgcatggta agaaatacct ccttctatca 306781 gaatgaattt ttaccttctt tactttattt atattgaaac aggaagatag gctgtatata 306841 atatagcaca tattgctact attcagaata attaatattt tcaaacagag gggatggatc 306901 gaaatatgag tatgccagca gccgaaacac agcctaagaa aaaacgtatg acatttaaaa 306961 tgcctgacgc ctatgtcctc ttatttatga ttgctttcat ttgcgcaatc gcttcatata 307021 ttgtgccggc aggtgaattt gaccgcgtga caaaggggga tgtcacgacc gctgttccgg 307081 gaagctatca ttcaattgaa cagtctccgg tcagattgat cagctttttt acttctctac 307141 aggatggaat ggttggatca gcacccatca tctttctgat tttattcaca ggcggcacca 307201 ttgctattct agaaaaaacg ggtgccatca atggcctgat ttacaatgtc atcagcaaat 307261 tccgcacaaa gcaattatta tttatttgta ttgtcggcgc attgttctcc attctcggaa 307321 caaccgggat tgtcgtgaat tcagttatcg gttttatccc catcggcctc attgtggcac 307381 gatccttaaa atgggacgca gtcgcgggag ccgctgttat atacatcggc tgctacgctg 307441 gatttaactc caccatatta tcaccgtcac cgctcggttt atcacaatca atcgcggagc 307501 tccctctttt ctcaggaatc ggcctgcgag ttgtgatata catatgcttt ttgctgtctt 307561 ctattattta tatctatttg tatacgagaa aattaaaaaa atcaaaagat gccagtgtgt 307621 taggaacaga ttggttccct gcggcaggaa tgggcgaagc cggtaaagaa gaagatcagt 307681 cagtgccgtt taccgttcgc cataagctga ttttggctgt ggcgggactc tcacttgtcg 307741 gatttttata cggcgctttg aagcttggct ggtcagattc ccaaatggct gcgacattta 307801 tttttatttc tgtccttgcc ggtttaatag gcgggcttgc ggcgaacgat attgccaaaa 307861 ccttcattac gggctgccaa agtcttgtat acggggcgct gattgtcggg atggcacgaa 307921 gcatttccgt tatccttgaa aatggaaagc ttctcgatac tgtcgtcaat gctttggctt 307981 cacttttgga tggattcagc ccgattgctg gggcaatcgg catgtatatc gccagtgcgc 308041 tgcttcattt tctcatctct tcaggttctg gcgaagccgt tgtatttatt ccaatcctgg 308101 cgccgctcgc tgatttgatg ggaatcacga gacaggttgc ggttgaagcg gttatgcttg 308161 gagaaggggt cgtcaactgt gtgaacccga catccggcgt tctcatggcg gtgcttgccg 308221 ccagcggtat tccgtatgtc aagtggctgc ggtttatggt gccgcttgct ctgatttggt 308281 tcttgatcgg gcttgtcttt atcgtgatcg gagtcatgat caattggggg ccgttttaac 308341 gattgctgcc cgccggcttg tacggcgggc ttttgagtta ttcattgcag aagcgcaggc 308401 tgttattgta acatgtaagc cataagccat tcgtaaaagt gcgggaggaa ggtcatgaat 308461 aatctgcgta atagactttc aggcgtgaat gggaaaaata agagagtaaa agaaaaagaa 308521 caaaaaatct ggtcggagat tgggatgata gcgggagcat ttgcgctgct tgatgtgatc 308581 atccgcggca ttatgtttga atttccgttt aaagaatggg ctgcaagcct tgtgtttttg 308641 ttcatcatta tcttatatta ctgcatcagg gctgcggcat ccggaatgct catgccgaga 308701 atagacacca aagaagaact gcaaaaacgg gtgaagcagc agcgaataga atcaattgcg 308761 gtcgcctttg cggtagtggt gcttacgatg tacgacaggg ggattcccca tacattcttc 308821 gcttggctga aaatgattct tctttttatc gtctgcggcg gcgttctgtt tctgcttcgg 308881 tatgtgattg tgaagctggc ttacagaaga gcggtaaaag aagaaataaa aaagaaatca 308941 tcttttttgt ttggaaagcg agggaagcgt tcacagtttc gggcagcttt ttttatagga 309001 acattgattt gtattcactc tgccaagttg ttttgataga gtgattgtga taattttaaa 309061 tgtaagcgtt aacaaaattc tccagtcttc acatcggttt gaaaggagga agcggaagaa 309121 tgaagtaaga gggatttttg actccgaagt aagtcttcaa aaaatcaaat aaggagtgtc 309181 aagaatgttt gcaaaacgat tcaaaacctc tttactgccg ttattcgctg gatttttatt 309241 gctgtttcat ttggttctgg caggaccggc ggctgcgagt gctgaaacgg cgaacaaatc 309301 gaatgagctt acagcaccgt cgatcaaaag cggaaccatt cttcatgcat ggaattggtc 309361 gttcaatacg ttaaaacaca atatgaagga tattcatgat gcaggatata cagccattca 309421 gacatctccg attaaccaag taaaggaagg gaatcaagga gataaaagca tgtcgaactg 309481 gtactggctg tatcagccga catcgtatca aattggcaac cgttacttag gtactgaaca 309541 agaatttaaa gaaatgtgtg cagccgctga agaatatggc ataaaggtca ttgttgacgc 309601 ggtcatcaat cataccacca gtgattatgc cgcgatttcc aatgaggtta agagtattcc 309661 aaactggaca catggaaaca cacaaattaa aaactggtct gatcgatggg atgtcacgca 309721 gaattcattg ctcgggctgt atgactggaa tacacaaaat acacaagtac agtcctatct 309781 gaaacggttc ttagacaggg cattgaatga cggggcagac ggttttcgat ttgatgccgc 309841 caaacatata gagcttccag atgatggcag ttacggcagt caattttggc cgaatatcac 309901 aaatacatct gcagagttcc aatacggaga aatcctgcag gatagtgcct ccagagatgc 309961 tgcatatgcg aattatatgg atgtgacagc gtctaactat gggcattcca taaggtccgc 310021 tttaaagaat cgtaatctgg gcgtgtcgaa tatctcccac tatgcatctg atgtgtctgc 310081 ggacaagcta gtgacatggg tagagtcgca tgatacgtat gccaatgatg atgaagagtc 310141 gacatggatg agcgatgatg atatccgttt aggctgggcg gtgatagctt ctcgttcagg 310201 cagtacgcct cttttctttt ccagacctga gggaggcgga aatggtgtga ggttcccggg 310261 gaaaagccaa ataggcgatc gcgggagtgc tttatttgaa gatcaggcta tcactgcggt 310321 caatagattt cacaatgtga tggctggaca gcctgaggaa ctctcgaacc cgaatggaaa 310381 caaccagata tttatgaatc agcgcggctc acatggcgtt gtgctggcaa atgcaggttc 310441 atcctctgtc tctatcaata cggcaacaaa attgcctgat ggcaggtatg acaataaagc 310501 tggagcgggt tcatttcaag tgaacgatgg taaactgaca ggcacgatca atgccaggtc 310561 tgtagctgtg ctttatcctg atgatattgc aaaagcgcct catgttttcc ttgagaatta 310621 caaaacaggt gtaacacatt ctttcaatga tcaactgacg attaccttgc gtgcagatgc 310681 gaatacaaca aaagccgttt atcaaatcaa taatggacca gagacggcgt ttaaggatgg 310741 agatcaattc acaatcggaa aaggagatcc atttggcaaa acatacacca tcatgttaaa 310801 aggaacgaac agtgatggtg taacgaggac cgagaaatac agttttgtta aaagagatcc 310861 agcgtcggcc aaaaccatcg gctatcaaaa tccgaatcat tggagccagg taaatgctta 310921 tatctataaa catgatggga gccgagtaat tgaattgacc ggatcttggc ctggaaaacc 310981 aatgactaaa aatgcagacg gaatttacac gctgacgctg cctgcggaca cggatacaac 311041 caacgcaaaa gtgattttta ataatggcag cgcccaagtg cccggtcaga atcagcctgg 311101 ctttgattac gtgctaaatg gtttatataa tgactcgggc ttaagcggtt ctcttcccca 311161 ttgagggcaa ggctagacgg gacttaccga aagaaaccat caatgatggt ttcttttttg 311221 ttcataaatc agacaaaact tttctcttgc aaaagtttgt gaagtgttgc acaatataaa 311281 tgtgaaatac ttcacaaaca aaaagacatc aaagagaaac ataccctgga aggatgatta 311341 atgatgaaca aacatgtaaa taaagtagct ttaatcggag cgggttttgt tggaagcagt 311401 tatgcatttg cgttaattaa ccaaggaatc acagatgagc ttgtggtcat tgatgtaaat 311461 aaagaaaaag caatgggcga tgtgatggat ttaaaccacg gaaaggcgtt tgcgccacaa 311521 ccggtcaaaa catcttacgg aacatatgaa gactgcaagg atgctgatat tgtctgcatt 311581 tgcgccggag caaaccaaaa acctggtgag acacgccttg aattagtaga aaagaacttg 311641 aagattttca aaggcatcgt tagtgaagtc atggcgagcg gatttgacgg cattttctta 311701 gtcgcgacaa atccggttga tatcctgact tacgcaacat ggaaattcag cggcctgcca 311761 aaagagcggg tgattggaag cggcacaaca cttgattctg cgagattccg tttcatgctg 311821 agcgaatact ttggcgcagc gcctcaaaac gtacacgcgc atattatcgg agagcacggc 311881 gacacagagc ttcctgtttg gagccacgcg aatgtcggcg gtgtgccggt cagtgaactc 311941 gttgagaaaa acgatgcgta caaacaagag gagctggacc aaattgtaga tgatgtgaaa 312001 aacgcagctt accatatcat tgagaaaaaa ggcgcgactt attatggggt tgcgatgagt 312061 cttgctcgca ttacaaaagc cattcttcat aatgaaaaca gcatattaac tgtcagcaca 312121 tatttggacg ggcaatacgg tgcagatgac gtgtacatcg gtgtgccggc tgtcgtgaat 312181 cgcggaggga tcgcaggtat cactgagctg aacttaaatg agaaagaaaa agaacagttc 312241 cttcacagcg ccggcgtcct taaaaacatt ttaaaacctc attttgcaga acaaaaagtc 312301 aactaaccgc aactttagag taaagggctg attgtcaatg tgggagcagt tgtatgatcc 312361 gtttggaaac gagtatgtga gcgcacttgt ggcgctcact ccgattctct tttttctttt 312421 ggctttaact gttttgaaaa tgaaaggcat tcttgcggca tttcttaccc tagccgtcag 312481 tttcttcgtc tccgtttggg catttcatat gccggttgaa aaagcgattt cttctgtttt 312541 gttaggaatc gggagcgggc tgtggcccat tggctacatc gtcctgatgg cggtgtggct 312601 gtataaaatc gccgtgaaaa ccgggaaatt taccattatt cggtccagca ttgccggcat 312661 ttcgcctgac caacgattac agctattatt aattggtttt tgttttaacg cgtttttaga 312721 aggcgcggcc ggttttggtg ttccgattgc gattagtgcg gcgctgctcg tcgaacttgg 312781 ttttaaaccg ttaaaagcgg cggcgctctg cttgattgca aacgctgcct ccggagcctt 312841 tggggcgatt gggattcctg tcatcacagg ggcgcagatt ggtgatttgt ctgctcttga 312901 gctgtctcgg acattaatgt ggacactgcc gatgatctca tttttaatac cattcctgct 312961 tgtattctta ttagaccgaa tgaaaggaat caaacagaca tggcccgctc ttctggttgt 313021 gagcggtggg tatacagcgg ttcagacact gacaatggcg gtgctcgggc cggaattagc 313081 aaacattttg gcggccttat tcagcatggg cgggcttgcc ctcttcctcc gcaaatggca 313141 gccgaaagag atttaccgcg aggaaggggc cggcgatgct ggtgagaaaa aggcataccg 313201 tgccgctgac attgcgaaag cgtggtctcc tttctacatt ttaactgcgg cgatcaccat 313261 ctggagcctt cctgccttca aagcgctttt ccaagaaggc gggctgttat atcaatcaac 313321 gctcctgttc aaaatgcctt ttctgcatca gcaaattatg aaaatgccgc cgattgcgcc 313381 atctgccatg ccgttagatg cagtctttaa agttgatctg ctgtcagcga ctggtacagc 313441 gattttagcg gcggtcatcg tgacagggct gttcagcaaa aagttctcct ctcgggatgc 313501 ctttgcttcc ttgaaggaga cgggaaaaga gctgtgggtg ccgattatga cgatctgctt 313561 cgtgatgggg tttgccaatc tggccaactt cgcagggctc agctcttcaa ttgggttagc 313621 attggcgaaa acaggagacc tgttcccgtt tgtcagtcct gttctcggct ggattggcgt 313681 gttcatcacc ggttctgttg tcagcaataa tgctttgttc ggccatttgc aggttgtcac 313741 gggagcgcag atcggtgcgg gttcagattt gctgttagcc gcaaatacgg cgggcggtgt 313801 catggcgaaa cttgtttctc ctcaatctat cgccatcgct gccgcagcgg tcggccaaac 313861 aggcaaggaa tctaaactgt ttaaaaggac agtggcgtac agcctgattc tgttattgat 313921 catttgtata tggacgttta ttcttgcaag attaggagtg taatagaaaa aagcagtaca 313981 tgcccagcat gtactgcttt ttttatgtta atttgctttc tttgtcattt cggctgttgt 314041 tttcactctg gcttttccca taaataaaat ggtaaccgcc gcgaggacaa ttggaatcaa 314101 agcgagcaaa aagacatacg tgatacttga tgacatcgcg tcaataatgc gattcaggat 314161 cgcatcagga atctgggaac gtgttcccgc ttggaatatc tcctgcgggt cgccaatatt 314221 ttgcgcagcg cctgatcccg ctgagccttt cataccgctg aaggcgtcat tcagcttgtt 314281 tgtgaatacg tttgtttgca ccgttccgaa aatggtgaca cctaaggtca tgccaaatga 314341 tcgcaaaaat gaatttgtag agtttgccgt tccccgaaag cgaggttcaa gatcattcat 314401 cgatgccgcc ggcagcaggg agaagttaaa gcctacacca aagcctgaaa tcatcataaa 314461 gactgtcagc catacccgtg ctgtgtcagg cgtcatattg gaaagaagca gcatgccgat 314521 aaagaaagct ataacagata tcagcatcaa attgcggaag cttgccttcg tttggaagat 314581 cccgccgatc atgcttccga tgactgatcc aatcatcatc ggcgtcagaa tgaagcccgc 314641 gcttgtcgcc gagctgccgt agaccgcctg aacgaaaatc ggaataaata ccgctaaaat 314701 aataaatgtt ccgccataca ggaaagcgag aatctgtgct gtggcaaaca agcggttctt 314761 aaacatccag aaagaaataa tcggctcttc tgcttttctc tccacaataa aaaaggcaat 314821 gaagaaaacg gcgaatacaa taaacagccc gatgatctga atggagttcc aatcgtatgt 314881 tttgccgcca agctcaaggg cgaacatcag gcatacaatg gatacgacta aggtaatcgc 314941 gccgccccag tctattttct gctttctgtg ctccagagat tctttgtagt agcgaataat 315001 gaaaaacaat gacaatgcgc cgatcggcac attgatgtaa aacacccagt gccagctgat 315061 cgaatctgta atgatcgcgc ctaagagcgg accaagaaca ctggataatc caaatacagc 315121 accgaacatg ccggacattt ttccgcgttt ttccggcgga aacaaatcaa agataatggt 315181 aaaggcaatc ggcaggagcg cgccgcctcc gatcccttga atggcccgga agatgatcag 315241 ctgattcatc gtctgggcaa tcccgcataa agcagaaccg attaagaaaa aaataagtcc 315301 aaacaggaaa aaacgttttc ggccgtacat atcggaaagc ttgccgtaaa tcggcatgcc 315361 agccataacc gccaccatat aggatgccgt cacccaggca aatttatcga agcttccaag 315421 atcggctacg atattgccca tcgcggtggc aacaatcgta ttgtccattg cagacatcaa 315481 gatgcccagc aggagaccga ggaccacaaa tttggtggaa gcctgttttg ctgttgttgt 315541 gtccatttgt tctacctcct cttacttttc tatgtaagtt ctgatatcat gataatagtt 315601 tgattgttga atatctcgat tatcaagata aactcgattt tatagggagg actgtcagtt 315661 gtcaacaaga aattccagaa gtgagttgga aaagactgct gttcagcttt ttcgaaaact 315721 gggcacaaga acggttctgt ttcatcaggc agccgctcaa gctctcggtc tgtttcccac 315781 cgatttgaaa tcagctgaca ttttaaatga agcagggccg atgacggccg gagagctggg 315841 gaaaaaaacc ggcctcagca cgggttccgt cacggcgctt gttgaccggc tggaaaaagc 315901 ggggtatgtg gctcgtgaaa aggacccgaa cgatcgcagg agagtcgtaa tcgtcccttt 315961 gactgcttcg aaaaaacata taaaggattt gttccgtcct ctgtctgagt caacgatgga 316021 tttgtgccgc gaatatacgg aagaggagct ggaactcatt ttcagttttg taggcaaagc 316081 tgccgatatt atggaggaag agcttgaacg tctgaaacag taagtgaatt tgtgcatagc 316141 ttggcccgtt cccgaataaa ttgtacaagt tacataagag aagggagtac gggccggtga 316201 acattttttt gagctatatt gtgctgggac tgtccttgtc tgcgcctgtg gggccagtga 316261 atgcggcgca aatagacaaa ggaattaaaa acggtttttg gcatgcatgg attttcggtt 316321 taggcgccat gacagcggat gggctgtaca tgctttttat ctatttcggg ctgtcgcagt 316381 tcttgaccgc tccatttgtg aaaacgtttt tgtggctgtt cggctttttt gtcctgacct 316441 ataccggaat tgaaacgctg aaaaacgtca gagaaccgat ggatgtgcga agctcgcggg 316501 ggaaaccgtc atacaggaaa acattcgcat cgggttttct catttcattg tcaaacccat 316561 tgagcatcct tttttggctt ggaatttacg gaagcattct tgcgaaaaca gcagaggcct 316621 acaatatgaa tcagcttcta atctatagct ccggcatcat gatcggcatt ttaatctggg 316681 atttctgcat ggctatcaca gccagtacgt tcagaaacct gcttcatgaa aagctattga 316741 gaggattgac cggaatcgcc ggtgtatccc tccttgtgtt tggcttttac tttggttatc 316801 agggcatcaa acagttattg ggctgattca tgaaggacag tcacctgccg cttccagttt 316861 taatatagta tccagatgat actggaggtg gatcaatggt gaatgggatt tacaccaaaa 316921 gttttctgga acgtattcag gaagagcttc ctgaatggca aagaatcgct tttgagctgc 316981 tggcagaaac tctgggggac gacgcggata catttccgtg cattcccgga cgccaggcgt 317041 ttctgactga tcagcttcgg attgcttttg ccggagatcc gcgggaaaac cgcacagcgg 317101 aggaactggc tccgttgctt gcggagtacg gcaagatatc gcgggacacg ggaaaatacg 317161 catccctcgt tgtgttgttt gatacaccgg aagatttggc ggagcattat tcgattgaag 317221 cgtatgaaga gctgttttgg cgctttttaa atagactgag tcatcaagac gaaaaagaat 317281 ggccggaaga cattccggcc gatcctgagc attataaatg ggagttttgt tttgacggcg 317341 agccgtattt cattctgtgc gctacaccgg ggcacgaggc aagaagaagc cggagctttc 317401 ctttttttat ggtcacgttt cagccaaggt gggtgtttga tgacctaaat ggatcaactg 317461 catttggccg taacatgagc aggctgatcc gatctcgttt agaggcctat gatcaggctc 317521 cgattcaccc gcaattaggc tggtacggag gaaaagataa tcgtgaatgg aagcagtatt 317581 tcctccgtga tgacgaaaaa caggtatcga agtgcccgtt ttcttattta aagaacatgt 317641 tcaacaaaat gaaataaatc aaggactggc agggcgatct ttatgaccct gctttttttg 317701 atagatcatg gtaacgatgg cgataatcac gagaaaacct atgctgacga aaaaaccggg 317761 ccggcttgat ttttcaaaca atgtaccgga cacagctgca gcaatcagaa ccatcgctaa 317821 ataaatttgc gtttttccca tgccctcggg atcagtcagc tttttgctgg agaacaggat 317881 aaacagccaa gtgtataaaa gcataagccc cgcagctgtt gtcatatgct cataaatgtt 317941 tttaggcagc actaacgaca aaataatgga gaggacaagc cccgcaaacg tcagcccaag 318001 tgccggccag catatttttt tgccttcctt tagagtaaag catttcggcg cgtcgccgtc 318061 atcagccatt gtacaaagca atgtcgtaac cgcaaatagc gaagcgacaa gggtcgagaa 318121 ccctgcgatg atgaaaatcc cgttaaatat atcaaggatg atctcaaggt tatatccttt 318181 taatgacgta atgaacggac tgtcctgttc agtaaacgtg tgtaacggaa ccaaaagcag 318241 agcaagcccg attgaaatga tataaataat cgccagcgtc gccagcatca gtttccctga 318301 tttagacgct tcctcaggtt tttttaagtg aaccgccatc agccccatga cctcaattcc 318361 gccaaaagcg taaaacgcgt agattaaacc tgtccacagc cccatggcgc cgtatgggaa 318421 aaactcactc gtcttatttg gaacatgtat gccatgattt ccgccggaca ggataccgca 318481 taaagccagg atggcaatga caataaacat aaaaatagca gctgttttaa tgactgccag 318541 cacgttttct gttttttcaa agacggacag gccggtgaaa ataataagga gcccaagtac 318601 tgcgtagatt gaggcaaaca cccatagcgg cacttgagga aaccaatgct tcgtaaagag 318661 cgaaatggct gtcagctggc ttccggtaat cagcatttct gatgtccagt acacccagcc 318721 gttgctgaag cctgcccatt tgccgaatgc ttttcgggca tacgcacaaa acgagccctt 318781 ttccggctgc ttcgccgata gcttggcgag ctgttcaaag acaaaatacg taccgatccc 318841 tgcgatcaga aatgaaagga gaacggaaaa accgcttttt acaattgcga tgctggaacc 318901 gagaaagaag cctgttccaa tcgtgcagcc gactccgatc agtgacagct gccaccaagc 318961 cagattccct tttggctggt ctttttttgt ttggctcatt atttattcaa ccccttttat 319021 ctaaggttag attgtgatct gtccaaagct tatatacatc ggatttttgc ctctttttac 319081 atggagaagg aagcagacgc tcatactaat gaaaaaagga gcaaaccaat gacacagcaa 319141 tatattgtgg agccgaaaaa agggcttggg ctgaagctga aaaaggggca gattttaaag 319201 gtggttgatg tagaagggca gcaggtggct gattttgtcg cataccatgc caaggatttt 319261 tatgaacacc ttgatcaggg agcgacgata gacgccaatc actccattca tgtgaaggtc 319321 aacgaccatc tctactccaa cctgtataag ccgatgttaa ccctgattga agatacggtc 319381 ggcaagcatg atctgctgtt gcccgcctgc cgtcctgata tgaacaggct cttatatggg 319441 aagcaaaagg atgagtttca ggatacgtgc tatgacaata tgaaccgtgc gcttgagcag 319501 tttggcgtac cgaagcccca catgcattac ccatttgcga tttttatgaa tactgtcctt 319561 gatgagaaag ggaatctgtc tgtggaaacg ccgctttcga atgccggaga ttatgtaagg 319621 ctcagggcgg agatggattt aattgtcgcg ttttcttcct gcccgattga aaaagggaaa 319681 tgcaatggcg acagtgtgac atccatacgg gttgaagtca gctgatctct cttgttcaca 319741 gtgaatgaag acctgtgcta tatttaatag ggatacataa cagtcatgat tcattttcat 319801 tgatttaggg aaatgatcag taataaggga aaatgtacag gaggaatgat tgggatgagc 319861 atgcaggaaa agattatgcg tgagttacat gtgaagccct caattgatcc aaagcaagaa 319921 attgaggacc gagtcaattt tttaaaacaa tatgtaaaga aaaccggtgc taaaggcttt 319981 gtattgggaa tcagcggggg ccaggattca acacttgcgg gaagactcgc tcagcttgcg 320041 gtggagagca ttcgcgagga gggcggagac gctcaattta tcgcggtccg tcttccgcat 320101 ggcacacagc aggatgaaga cgatgcccag cttgctttga agtttattaa gccggataaa 320161 tcatggaagt ttgatattaa atcgacagtc agcgcttttt ctgatcagta tcagcaggaa 320221 acaggcgatc agctgacgga ctttaataaa ggaaacgtaa aagcaagaac aagaatgatc 320281 gcgcaatacg cgatcggcgg ccaggaaggt cttcttgtgt taggaacaga ccatgctgct 320341 gaagcagtga ctggtttctt tacgaagtac ggtgacggcg gagcagacct cctgccgctg 320401 acaggcttga cgaagcgcca gggaagaacc ttgctgaaag agctgggtgc accggaacgc 320461 ttatacttaa aagaaccgac tgccgatctg ctcgacgaaa aaccgcagca gtcggatgaa 320521 acagagcttg gcatttccta cgacgagatt gacgattatc tcgaaggaaa agaagtatca 320581 gcgaaagtat cagaagcgct ggaaaaacgc tacagcatga ctgaacataa acgccaggtt 320641 ccggcgtcta tgtttgatga ctggtggaaa taagttgaag aaagcccgct ctcggagcgg 320701 gcttttgtcg tgtacagaag ctttatttga tgcggatatg attcagcttt accattaatc 320761 tgtcggcgaa ccttcggagg ctgcctcttg tatcaggatc taatgggagt tcggctctcg 320821 cggcaatgtt ctctgccaca tcctgaatcg acaggttgtc tgtttgaatg tggtcctcaa 320881 aaatgggtga tgataatcct tcaacacagc ggtcaatttg tttggcggcc catgagtttt 320941 ttccttctgc tctggtgcgc agccttttta acaaggtttc ctttgaagcc attagtgtaa 321001 agtggtgaac gatcctgcct tcctgtctga gcctgccgat gatctcattg aagtattcag 321061 ggtgtacaat cgtcataggc acaataagga tgccgcggta tgtatctgtc agagaagcta 321121 gcaaactgta attgaacgcc cgccataaag gatagctttg aaaatcgtcc tttgcgatct 321181 cctgcggcac catggagcgc agcgcaaaac ccattttctc gggatcatac acgtaagatg 321241 ggttcagcct tctgtgcagt tcgaaggctg tttgtgtttt tcccgaaccg aatgccccgt 321301 ttatccaaat gatcatcgcc atttctccct tcctatttat catacagaaa aagacccttc 321361 catcgaagag tcagctggaa aaacaataaa ggcggaaggt tttaacgctt ttttgcgtcg 321421 aagtattaaa atacctgcag aaatgttgta caatgaatgt cattcaggca aaaatggcta 321481 caacaaagcg cactataagc ttgaccggta aagccggtat ctatataaat attcgctaaa 321541 taagcatata atgaatatat aatttcattc cttaggagga tttcgccgaa gatgaacgct 321601 aaacgagcca tcccagtaag agaaagaaat atcgtcctga tcggattcat gggtgtagga 321661 aaaacaacaa tcggccaatt ggtcgctaaa aaattatata gagattttat tgatattgac 321721 cagcagatcg aaaaggattt caatatgtca attcctgaga tatttgagaa aaagggagaa 321781 gactttttcc ggaaaacgga gaaggaatat attttagaca tctgccatca taaacgattc 321841 aaaatcgtat ctctgggcgg gggatctttt aaacaagaag aaatcagaaa ttgctgtctg 321901 gaaaactgtc tcgtgcttca tctggacctg tcatgggaga actggaagca gcgcgcggat 321961 ttattgatcg aaagccgccc tgtactgcat aaccgttcaa tggatgaaat ggaacagctg 322021 tttaacgaaa gaaaagtcat ttatgacaag cacaattcaa aagtggcaac agacaacctt 322081 tccccggaag aggttgccga ttacattgtt gagacattaa aaattggctg ggatctttat 322141 cagccgatgt aaaaagccgt gcgcagcgca cggctttttt tatcgtttta tcccttgtat 322201 caaaatcgct tttaaacaaa aggagatggg ctgtccgttt tggttcaatg taatacagaa 322261 cgtgtcgcgt gcttcgtctg atgcgtgatt caagtgggta atgatttgtt tttctcggtc 322321 agcgggggtt ccgcctcgtt tgatccagct atcgtattga atcggcaagt tccacttttg 322381 gatgtcttga taggccagtt gattggcgct gaacatcgcc tgccattctg ataatgagct 322441 ttcacgaaca tgggaagggt ctcgaagccg gttcaaatga ttgacaaact catcaagaac 322501 gggatcttca ggcgcgtaat gatcaactaa gagaaaacgt ccgtcctgtt ttagtacgcg 322561 tgcaacctct ctgacagctt tgcggacatc tgaaaaatgg tgggctgcgt atcggcaggt 322621 gatgatgtca aatgaatcgt cggggaaggg gagtgactct gccgttcctt gctgaaagcg 322681 tacgttttca actccttttt cttgcgcgaa ggaggacgca acctcaacca tctctttcgt 322741 tgcatcaaca ccgatgcact cctgtacata aggagaaaat gccagcgccg tatggccggc 322801 gcccgctcct atatccagca ctcgatgctc tgcccggcat tccgctgttt tgatcatcaa 322861 ccccaaatct tccccctcgg caaatacctt ttcatcccga tacatctcgg cgtttttaga 322921 aaacggtgtt tcatttgtca tttgaaccag ctccttcttt tcgtaaatga tgatatggat 322981 tatgttagca atttctgtta tgattcgtcc aagatataaa aatgatgaaa atgataggtt 323041 caacctatgg aggctgaaat ggatattaaa gtgatggaat atgcagcgga aattgcccgg 323101 cgccaaagct ttacaaaggc ggcggaacat cttcatatcg cacagccgtc tctcagccag 323161 caaatcaaaa agcttgaggc tgagctgggg cttacccttt ttcacagatc ccatggctct 323221 gttacactga cacctcacgg caggcgtttc attgaaaaag ccgaggacat cattcgttcc 323281 agagatgatt tgcttcggga aatgcaggag cgatcacagg gaatcggtca taaattatcc 323341 atcgggattc ctgctgtaac agggagatat ctctttcctc cgctgctgaa gcagtttttg 323401 gcgcgctatc ctcatgtgga ggttcagctt gttgaaaaag atccggtttc attagagaag 323461 atgacggcaa agggagaagt tgacctttct gttttatcct tgcccatcga ggatgaacgg 323521 ctctccatta cacccttgct cacggaaccg gttgttctcg cggtgccgaa ggaaaaacaa 323581 aggtggatgc cgccggaatt ggtcgcgctg attgagaaag cgctggaaga agatgaggga 323641 cgccagccgt gtgtgccgat tgacatggta aggaacgtgc cctttattct gttaaaagaa 323701 ggcttcggct ttcgcaggac agttctcgat ctctgtgcgg aaagcggctt taagccgaat 323761 gctgccttta agacgagcca tattgaaacc gcccaatctc ttgtggctaa cggattaggt 323821 gtgacaatgg caccgaatat ggtcagaagg gataaagatc cgggtgtgat ctatttatcg 323881 attcaatccg cgccatcacg aaccctcgtc tttgtctttt taaagaaccg ctatgtcagt 323941 ctgacggccc aggcctttat ggaactaagc cgggaaagtc ttaaacaaac gtttgatgaa 324001 ggctgtctgg gaaacaaaga tgaaaatatt tagaaaacaa agacgaaacg tggtagtata 324061 ggaatacaaa ctaaatctta taaaacaaag gggaataatc ggaaatgcaa ctattcgatc 324121 tgccgctcga ccaattgcaa acatataagc ctgaaaaaac agcaccgaaa gatttttctg 324181 agttttggaa attgtctttg gaggaacttg caaaagtcca agcagaacct gatttacagc 324241 cggttgacta tcctgctgac ggagtaaaag tgtaccgtct cacatataaa agcttcggaa 324301 acgcccgcat taccggatgg tacgcggtgc ctgacaagga aggcccgcat ccggcgatcg 324361 tgaaatatca tggctacaat gcaagctatg atggtgagat tcatgaaatg gtaaactggg 324421 cactccatgg ctacgccaca ttcggcatgc ttgtccgcgg ccagcagagc agcgaggata 324481 cgagtatttc accgcacggt cacgctttgg gctggatgac gaaaggaatt cttgataaag 324541 atacatacta ttaccgcggt gtttatttgg acgccgtccg cgcgcttgag gtcatcagca 324601 gcttcgacga ggttgacgaa acaaggatcg gtgtgacagg aggaagccaa ggcggaggtt 324661 taaccattgc cgcagcagcg ctgtcagaca ttccaaaagc cgcggttgcc gattatcctt 324721 atttaagcaa cttcgaacgg gccattgatg tggcgcttga acagccgtac cttgaaatca 324781 attccttctt cagaagaaat ggcagcccgg aaacagaagt gcaggcgatg aagacacttt 324841 catatttcga tattatgaat ctcgctgacc gagtgaaggt gcctgtcctg atgtcaatcg 324901 gcctgattga caaggtcacg ccgccgtcca ccgtgtttgc cgcctacaat catttggaaa 324961 caaagaaaga gctgaaggtg taccgctact tcggacatga gtatatccct gcttttcaaa 325021 ctgaaaaact tgctttcttt aagcagcatc ttaaaggctg ataaatgtga aaagccgccg 325081 catatcatca ggcggttttt ttctgcaaac tgccggaatg agaacagact ggagacgaat 325141 agatatgaaa caaagaatca ttgatgaatt aaaacggatc gagcagtcat acggagtcaa 325201 aatcgtgtat gccgtcgagt caggaagccg cgcatgggga tttccctcgc aggatagtga 325261 ttacgacgtc cgctttattt atgttccgaa aaaggagtgg tacttttcaa ttgagcagga 325321 gcgtgatgtc attgaggaac cgattcacga tttgctggat atcagcggct gggagctgag 325381 aaaaacgctt cggcttttca aaaagtcaaa ccctccgcta ctcgaatggc tgtcctcaga 325441 cattgtgtat tatgaagcat ttacgaccgc agagcagtta agaaaactcc gcacggaggc 325501 atttaagcct gaagcaagcg tgtatcacta tatcaatatg gcgagaagga acgtcaagga 325561 ttatctacaa ggacaagagg tcaaaattaa aaagtacttc tacgttcttc ggcctatttt 325621 ggcctgccaa tggattgaaa agcacggaac cataccgcca atggacttta ctgttttgat 325681 gaatgaactt gttgctgaac ccgagctgaa ggctgaaatg gaaaccttgc ttgaacggaa 325741 aagaagaggg gaagagcttg acctcgaagc aagaatcgat gttattcacc aattcattga 325801 aacggaaatc gaaagaatca tggaagcggc aaaagaactg aaggcagaga aaaaagatat 325861 gacatctgaa ttgaaccgtt tgcttttgaa tacggttgaa gaagtgtgga aggatggagg 325921 aagctgatgt tttttgtcgc ttccttttct cctttattcg acagaatccc cccccgactt 325981 tctaactatc tgattgtggc aaacccacaa aaataatcag aatctttgta ttttgagaat 326041 attgtgaacg ctggttttgt ccatttacaa taaactcata caaatacttc ttagattgcg 326101 gggtgttgag gttggaagtg atcacaagag attttttctt atttttatcc aaaagcggct 326161 ttctcaataa aatggcgagg aactggggaa gtcgggtagc agcgggtaaa attatcggcg 326221 ggaatgactt taacagttca atcccgacca ttcgacagct taacagccaa ggcttgtcag 326281 ttactgtcga tcatttaggc gagtttgtga acagcgccga ggtcgcacgg gagcgtacgg 326341 aagagtgcat tcaaaccatt gcgaccatcg cggatcagga gctgaactca cacgtttctt 326401 taaaaatgac gtctttaggt ttggatatag atatggattt ggtgtatgaa aatatgacaa 326461 aaatccttca gacggccgag aaacataaaa tcatggtcac cattgacatg gaggacgaag 326521 tcagatgcca gaaaacgctt gatattttca aagatttcag aaagaaatac gagcatgtga 326581 gcacagtgct gcaagcctat ctgtaccgga cggaaaaaga cattgacgat ttggattctt 326641 taaacccgtt ccttcgcctt gtaaaaggag cttataaaga atcagaaaaa gtagctttcc 326701 cggagaaaag cgatgtcgat gaaaattaca aaaaaatcat ccgaaagcag ctcttaaacg 326761 gtcactatac agcgattgcc acacatgacg acaaaatgat cgactttaca aagcagcttg 326821 ccaaggaaca tggcattgcc aatgacaagt ttgaatttca gatgctgtac ggcatgcggt 326881 cgcaaaccca gctcagcctc gtaaaagaag gttataacat gagagtctac ctgccatacg 326941 gcgaggattg gtacggctac tttatgagac gccttgcaga acgtccgtca aacattgcat 327001 ttgctttcaa aggaatgaca aagaagtaaa aaaggagaga ttatcatgac aacaccttac 327061 aaacacgagc cattcacaaa tttccaagat caaaacaacg tggaagcgtt taaaaaagcg 327121 cttgcgacag taagcgaata tttaggaaaa gactatccgc ttgtcattaa cggcgagaga 327181 gtggaaacgg aagcgaaaat cgtttcaatc aacccagctg ataaagaaga agtcgtcggc 327241 cgagtgtcaa aagcgtctca agagcacgct gagcaagcga ttcaagcggc tgcaaaagca 327301 tttgaagagt ggagatacac gtctcctgaa gagagagcgg ctgtcctgtt ccgcgctgct 327361 gccaaagtcc gcagaagaaa acatgaattc tcagctttgc ttgtgaaaga agcaggaaag 327421 ccttggaacg aggcggatgc cgatacggct gaagcgattg acttcatgga gtattatgca 327481 cgccaaatga tcgaactggc aaaaggcaaa ccggtcaaca gccgtgaagg cgagaaaaac 327541 caatatgtat acacgccgac tggagtgaca gtcgttatcc cgccttggaa cttcttgttt 327601 gcgatcatgg caggcacaac agtggcgccg atcgttactg gaaacacagt ggttctgaaa 327661 cctgcgagtg ctacacctgt tattgcagca aaatttgttg aggtgcttga agagtccgga 327721 ttgccaaaag gcgtagtcaa ctttgttccg ggaagcggag cggaagtagg cgactatctt 327781 gttgaccatc cgaaaacaag ccttatcaca tttacgggat caagagaagt tggtacgaga 327841 attttcgaac gcgcggcgaa ggttcagccg ggccagcagc atttaaagcg tgtcatcgct 327901 gaaatgggcg gtaaagatac ggttgttgtt gatgaggatg cggacattga attagcggct 327961 caatcgatct ttacttcagc attcggcttt gcgggacaaa aatgctctgc aggttcacgt 328021 gcagtagttc atgaaaaagt gtatgatcaa gtattagagc gtgtcattga aattacggaa 328081 tcaaaagtaa cagctaaacc tgacagtgca gatgtttata tgggacctgt cattgaccaa 328141 ggttcttatg ataaaattat gagctatatt gagatcggaa aacaggaagg gcgtttagta 328201 agcggcggta ctggtgatga ttcgaaagga tacttcatca aaccgacgat cttcgctgac 328261 cttgatccga aagcaagact catgcaggaa gaaattttcg gacctgtcgt tgcattttgt 328321 aaagtgtcag actttgatga agctttagaa gtggcaaaca atactgaata tggtttgaca 328381 ggcgcggtta tcacaaacaa ccgcaagcac atcgagcgtg cgaaacagga attccatgtc 328441 ggaaacctat acttcaaccg caactgtaca ggtgctatcg tcggctacca tccgtttggc 328501 ggcttcaaaa tgtcgggaac ggattcaaaa gcaggcgggc cggattactt ggctctgcat 328561 atgcaagcaa aaacaatcag tgaaatgttc taagcgggac taaatgggca tcctccctgc 328621 gggggtgtcc atttcatcca tatactataa aaaagaggag gaagtgccat agaaaacaca 328681 cagctgatta tttcgatttg tatttatatg gcgggaatgc tgctaatcgg ctactttgct 328741 tacaagcgta cgtcgaatct gacggattat atgctgggag gacgctcttt gggtccggca 328801 gtaaccgctc tcagtgccgg cgctgccgat atgagcggct ggctgctaat ggggcttccg 328861 ggcgccatgt tttctactgg tctgagcggc gcttggatcg tcatcggact ttgccttgga 328921 gcgtgggcga actggcttta cgtcgcacca cggctgagaa cctatactga aaaagcgggg 328981 aattctatta caattcccgg attcctggaa aatcgcttcg gagatcaaac aaagcttctc 329041 agactgtttt cgggaattgt cattttagtc tttttcacgt tttatgtatc gtccggaatg 329101 gtgtccggcg gcgtcttatt caacagcatc ttggggatgg attatcacac cggcctgtgg 329161 attgtgacgg gtgttgttgt ggcatatacc ctgtttggcg gctttttggc agtcagctgg 329221 acagattttg ttcaggggat tattatgttt gccgcactca ttcttgtgcc gatcgttacg 329281 tttttccaca cgggaggagc aggtgataca gttgctgaaa tccgctctgt agatcctgat 329341 atgtttaata ttttcaaagg aacgagcgtc cttggcatta tttctttgtt tgcctggggg 329401 ctgggatact ttggccagcc gcatattatt gtgcgtttta tggcgataac gtctgtcaaa 329461 gagatcaaaa gagcgcgcag aattgggatg ggctggatga ttttgtctgc agtaggcgca 329521 gtgctgaccg gtttgggcgg aatcgcttat taccatcagc gcggcatgac actgaaggac 329581 ccagagacga tttttattca attagggaat atcttgttcc atccgattat cacgggtttt 329641 ctgatttcag cgattttggc cgcgattatg agtacaattt cttcccagct gcttgtgaca 329701 tcaagctctc tggtagaaga tttgtataag tcgatgttca gacgctcagc ttcagataaa 329761 gaactggtgt ttttaggccg actggctgtt ctggctgttt caattgtcgc gttggttctg 329821 gcttgggaga aaaataacac catccttgga ttggtcagct acgcgtgggc gggcttcggt 329881 gcatcattcg ggccagttgt actgctcagt ctgttttgga aacgaatgac caaatggggg 329941 gcactcgccg gcatgattgt gggagcagcg actgtaatca tttgggcgaa tgccggtctt 330001 tcggactttc tgtatgaaat gatacctggt tttgctgcga gtctattatc tgtctttttt 330061 gtcagcatat tgacgcaggc tccgtcacaa gctgtcacag accagttcaa cgactaccaa 330121 gatacaatgt cgcaataaag atcgaaagga ggaggaaggg gctgtccctt tttcctcttt 330181 tctcctttta agcggccatt tttttctttt ggaaacaaac gtattttttt ctatacaaaa 330241 agaccccgta tggatatgat taaagtaaaa aaagtatagg agaaaaaggt atggaagagc 330301 ttttagagag agttttttca ttttcagatg ttgataagct aattgatttt attagctatg 330361 aactgcaaaa gccagtgata ctggaaagcg cggatttctt tttgttagcc tataattctt 330421 actatattaa ccattttgat tctgccaacc agcagactat tttttcgaaa aagtgtccgg 330481 tccagatttt tgagaggttt ctgaaggacg gaattattga aaaattgaaa acagagcctg 330541 agccttttcg cgtcaataaa attgaaagca ttgggttaaa ccagagggtg gtcgtgagtg 330601 caaagcacaa aggggaagtc atgggctaca tctggattca ggagctggac caaaatctga 330661 cggatgaaga gctcgacttt ttgtacgaga cctccttcca tgtcgggaaa atcatttata 330721 aaacgaataa attgaaacag gaaaaggaag aaaaagcaga ggatctcatc aaacgggcga 330781 tctatcagca atttacctct gagaaggaac tcagacggga agctgaaagg atcaacaccg 330841 tgctgccttc catgttttca gttgttatcc tgcacgccgc aaatggggat ggggaagcgg 330901 ttgaggattt aaaggaaaat atcaggtcgt acctgaattt acgggataag gtcagtcatg 330961 tcttaacgat cgaatcaaac attgtcatcg tcgtagcgag tttttcccaa aaaagctccg 331021 tctcctcagc agcttctgag tttattaaca agctgttaac acattttcac tttcaaaaaa 331081 tacctacccc tatttatatc ggtatcggaa acgaatataa tcacctatta aaacttggca 331141 agagctacac agaagcactt gaagtcatca aagccgcaga aatcaccggc aatcaggaaa 331201 acattccata tgaatatgcc aaactcggca tttaccgcta tttagaaagc atcgaacaga 331261 aaaatgaatt tttagaatac gagaataaag atttagcttt attaaaagca aaagacgaag 331321 aaagcagcac tgagctgctc aaaaccttgg aaatctatct cctcaacaac tgcaaaacaa 331381 aaccagcggc agaacagctg tttattcacc aaaatacatt gaattaccgc atcaaacaga 331441 ttactgagat gacgtcgatc gatttaagcg atttcagaac gcggtgccag ctctatctcg 331501 atttgatgct gatgaaaaag aaataaaaaa gaaaccagta cttgtactgg tttcgtcttc 331561 acttaaaatc ctctgtaaac atacggatca tcaggttttt taatggtatt ccagtcagtt 331621 actttgacga cagggagagt tgacttgaat ggctggtaat attctgaggc cagagtgccc 331681 ttaatgtgaa tccattcatc atccttgatg tccatgtcct tcggaaattc cacaagcatc 331741 ccgtacacgc cggaatcagc gatacagtga atgatgccaa accttaatac gaacagctga 331801 tttttgttaa ttgcgtttcc tttgtaagca aatccatgaa attctatcgt ccgtccgaga 331861 aattcacccg gatagttata gatggtttcc attcctttta ggaaatcgtc atcggtcaga 331921 gaaatctctt ttttgctgga atacttatta aacagctgtt tcatttgttt gtcatagctg 331981 tcttgcgcgt aataaaggct ggcatcaggc cgcaaatact gtgtttggga gtagtgatct 332041 ccgctctcca tcgccttaaa cgagaaccct tttgttttga ctatggatga gtcaagcgtt 332101 gcaatcggga agaagatgcc tgacaccaaa ggaaaaagaa aaacaacata aatcaaataa 332161 cgctgataaa atggcttgtt ttgttcatgg tcatgctcgt gatcatggcc gcacccgcaa 332221 tcatggtcat ggtgatgtcc gcttttttca ggcgacttga taaatagata tgcttggacg 332281 gcggtcagaa tggccagcag gaagatcgca ataaaggaaa gataggcata tttcatattg 332341 atatattttg ttagatttcc tgaggcatgc agatgataaa agaaaaacgt aaatcccatc 332401 agcaccaata aacgaaacat ccaatcaccc ctttaccagt agtgatcccg ctaaaacaat 332461 cacgacaatg tatgtaatca gcaggaaaac aaatcgtttt ttgaaggccg caagcatcat 332521 caatagattc ttaatatcca ccattgcacc aaagacgaga aaggcgatta acgatcctaa 332581 tgaaaacgtg ctgctgaagg aagacgcgat gaacgcatca acttctgaac aaagcgacag 332641 gacaaacgcc agacccatca tcacgaggga agaggataca tcattctgcc cgatcgcaag 332701 cagagtggat gttttgacat acgtctgcat agcggctgcg ataaaggcgc cgatgattaa 332761 atatttcccc acggagaaaa attcatcaat ggcatgccgc aaggtcccgc ccagtttttg 332821 gagcaaggtg ccgtgatgat gatggtggtg cccgggttca tcaggcttta aaagctggtt 332881 atccttaaat tgataggata agatgacccc gatgatcagc gaaacggcga gagccagtcc 332941 gcctctgtaa aagaccacgc tccatctatt cccgaacgca atataagtag aaaataaaac 333001 gataggatta atgataggcg cggtcagcat gaaagcaacg cccgcatgca gaggaactcc 333061 ctttaacaga agccgcctcg taatcgggat gatgccgcat tcgcaggcgg gaaataaaac 333121 gccggccagc gcaccgaata aaacggcgag aaaacggttt ttcggcatga ttcttgcaat 333181 catttcttca gaaacaaaca tttgaatgat tccggaaagt atgacgccaa tcagaataaa 333241 cggaatggct tctattaaaa tgctgataaa aatagaattc agctgaagaa aagatgattg 333301 tgctgtcaca ataaaacctc cgctcatgtt aagctgcctt tcttatgata ccagaaaaaa 333361 aggcactgct tgtttgacgg aggaggggaa aggatcgttt cactttggtt aggattccaa 333421 aaagccgagt aggatactgc ctgtttctgc agcttctttt ccgagccaaa tcaggtgtcc 333481 ccatgagtga agcaaacaga gaacagcgcc acgaatgtgc tcttttgcat gatgtgcatg 333541 tgacaagtca accaatccgt cataaacact ttgcataatc agcacgggac atatgatggc 333601 ttgcaggtct tttaaagaga cagcggcggt ttgtgacaag tcaatcagaa atccttcacc 333661 cgagcgctgc cggctgttca ttttccgaaa tgcttctatg tctttttcat tcatcaagga 333721 cttgattcgc tgaaacggaa gcgtgctgaa ttgggggctc atagctcgaa acatcaaacg 333781 cgggaaagcg ttattcaagg aagaaatcag cttccatatc cacttttcca ccggcgggcg 333841 gaagagaatt tcccccaatt tatattcagt gtcttttggg gtgagccact ctttggtgac 333901 tgcggattgc agggtcaatg tatttactct ttccggataa tgtgaggcaa agcatatgcc 333961 gctcggccct cctgctgaga tggcgatcac atggacactc tcgatttgta gatgatctaa 334021 taatttcaca tagaaacggc aggcattggc aagacttttt ccaatttctt ttgacgtccg 334081 tccatagcca ggccttgaag gcgtaatgat ggaataccct tgttcaatca acgctgtgta 334141 tccgaattcc tcgtaacaat ttgaatgccc gccatgcatg acaaggatcg gagttccctt 334201 gcctgtcaca gaatattcta gtgtaccgcc atcgaaggtg atcgtttcaa ctcgtctttt 334261 catctgtttc acccaattgg tttttgccta ttatagagtt ttcagcaatt gaccacaagg 334321 tagaagaaat gaataaacaa aggcccttga aatatgatat actttgtatt gatattcatt 334381 ctcaattaaa actttgatat agatgtgaac gggaggcagg acggatggct gagaatcaag 334441 aggtatatga cgttacgatt ataggcgggg ggccgatcgg gctgtttact gctttttact 334501 gcgggatgcg ggagctgaaa acaaaggtaa tcgaattttt gccgaagctc ggagggaagg 334561 tgtctttatt ctttcctgag aaaatcattc gcgatatcgg cggcataccg gggattgcgg 334621 gaaagcagct gatcgagcag ctgaaggagc aggcggcaac gtttgatcct gatatcgtat 334681 tgaatcagcg tgtgaccggg tttgaacgcc tagatgacgg caccattgtt ctgacgggtt 334741 ctgaagggaa aaagcactat acaagaactg tgattttggc ttgcggcatg ggtacacttg 334801 aggtcaatga gtttgacagc gaggatgcgg cccgatatgc gggcaaaaat cttcattatg 334861 gagtggagaa gctcgatgcg tttaaaggga aacgcgtggt gatatcaggc ggcggagata 334921 ctgcggtcga ttgggctaat gagcttgaac cgattgcggc gtctgtgact gtcgttcatc 334981 ggcgtgagga attcggcgga atggaaagca gcgtgacgaa aatgaagcaa tcatcggtgc 335041 gggtgcttac gccttatcgg ctggagcagt tgaacggaga tgaagagggc atcaaaagcg 335101 tgaccgtttg tcatactgag tctggccaga ggaaagacat agaaattgat gagctgatca 335161 ttaatcatgg gttcaaaatt gatctcgggc cgatgatgga gtgggggctg gagattgaag 335221 aaggaagggt gaaagctgac agacatatgc gaacgaatct tccgggcgtg tttgtggcgg 335281 gcgacgcggc tttttatgaa agcaagctga gattgattgc cggcggattt acggaaggcc 335341 cgacagcggt caacagtgcc aaggcttatc tggaccctaa ggccgagaat atggcgatgt 335401 attccaccca tcataaaaaa ttggtgcata aataaaacag cccttgagga aaagggctgc 335461 ttgccatcag gtgtgaagga gttttttctc tgcatgttga ttgtggatga aagctagcaa 335521 ttcatcctgt tcttgtacgg ctgtgaatcc ataaatgccg gcagctgagt catcgcctat 335581 gcagacgata ggagggcggc ttgctgacgg ttccggcaaa atgccaattt gttcgccacc 335641 attgatcaat tgctgaacgg acagcttgtt tgggcaaatg accatgtgca gcggggattc 335701 actgatggta cgctgaatca tgtgggtgaa ccggtcatct atgacgtttt catgagtgat 335761 ataaaacgaa caggattcat gcttttgcat gttttccact gcatggcggc tcccgacaac 335821 aagacgtttc tctgaatcag gctgaatggc ggtgacaaga aagccccgtt tctcaagctc 335881 tgtctttgct tgctcagatg ctgcactcag tttggctgtc agctggcgga tgtcgatttt 335941 ctgagaagcc agtgctctga aaaattcaca aaccgcccgg cgcgatgtga aaaaaacgtc 336001 ttcaaaggtg ccaatctttc gaagaatttc ttcattgaca ggcatgtttt cggtccgcca 336061 tttcggccac tcgatgagat cggcgccgga atcgcgcagc ttgtctgcaa gcgggtcttc 336121 atcttcgcca tgagtcacaa ccatcaaatg ccgtccgatg agcggtttgc tttcaaacca 336181 gctgtgtgtt tgaaagttga cgatgtctcc gatgacgata atcgcagggt ttgtaatctg 336241 gtgttcctgc actttttgct gaatgttctc aagtgttcct ttcacactcc gctggcggcc 336301 ccacgttccc cattggatga caatgacagg gacagaaggc gatttcccgt atgaaataag 336361 ctgctggcaa atataagaca agttcttgac acccatgtaa aaaacaaggg tttgaacgct 336421 tcgggccagc ccttcccagt caaggttcgg cgtgcctttt aatgatttat catgcgctgt 336481 aatcatggca aaagacgatg caaaatcccg atgcgtgacg gggatgcccg catatagcgg 336541 cgctgcaatt ccagaggtga ttcccggcac catttcatag cgaatgccgt gctcatgaag 336601 agcatctgct tcctcgccga ctctgccgaa tacgctcgga tctccgccct tcaagcgaac 336661 gacggttaac ccatttaatg ctttttcaac cagcagggcg ttaatttctt tttgtttcat 336721 aaaatggcgg tttggcagtt ttccgcaata aataaactgg cagtccggtg atgcaaattc 336781 gagcagcttc gggttggcga gccggtcata taaaatcaca tctgcttcct tgagcgcctg 336841 ttttcctttg atggtgagca ggcctgggtc gccgggtccg gctcccacga aatatacgat 336901 tccgttcttc atgatcatgt catccttccg tcactgtaaa aaatgaagga ccactagaaa 336961 agtgatccgg tcttttgatc aatatacgag ataaacatgt tctccttcga tcagcgtttc 337021 atatgttttg acgcatccgt ggtcaggttc ttggacgatt ccgtcttcta aggaaatttt 337081 ccagtcgtgc atcgggcaga aaacatattg accgctgacg atgccttctg ccaggacgcc 337141 gcccttatgc ggacagcggt tttcaatggc gcggatgctt ccgtctgaaa gcttgaaaac 337201 cgcgagctcc ttatcttcaa tatacactgt tttgcctaat tgttcaggca attcttcaat 337261 ttttccgata catacttttg ttacgtcttt gtttaccatg tccattcctc ctcaatgata 337321 gtttttgtca ttatgatgtg gtcacgacat tttcaaataa ttctttagag gtttgtttat 337381 cctctaaaaa gtctttccac ggatccttgt ggacagagag tgtttcattc attcggccgt 337441 tcagctcctg ccgcttttcc ggatcgttta acacggattg gacatgggat aaaccgacgc 337501 gctcaagcca tgcggacgta cgctccagat agtttgcggt ttccctgtaa tattgcaggt 337561 aagcgcccgc gtattctaag acttcttcat ttgttttcac cttcatcagc aaatcgccgg 337621 cacgcaaatg ggttccgccg tttccgccga cataaagctc ccagcctccg tcgatgccga 337681 caacgccaag gtccttaatg ccggattccg cacagtttcg cgggcaggca gacacggcca 337741 ttttgacttt gtgaggcgtg ttcagccctt cgaatttttt ctcaagcgca atgcccagtg 337801 ccatggagtc ttgtgtgccg aagcggcaga attgctcgcc tacacatgtt ttcactgtgc 337861 ggagcgtttt tccgtacgcg tagcccgatg gcatatcaag atcttcccat accttcggaa 337921 ggtcttcttt tttcacgccg ataagatcaa ttcgctggcc gcctgtcatt ttcacgagcg 337981 ggatctcata tttgtcaacg acatcggcga tcttgcgcaa atctgtggag ttggtcacgc 338041 cgccgtacat ccgaggaacg actgagtatg ttccgtcttt ttgaatattg gcgtgcattc 338101 gttcattaac aaagcgggat gtccggtcat cctcgtattt ggttggattg atcatgccta 338161 agtagtagtt cagagcgggt cggcatttag aacagccttc tggcgttttc cagccgagca 338221 cattcatgac ttctcttgta tgtgacagcc ctttggcttt gatttcttct acgacttcat 338281 ctctcgacaa tgtggtgcag ccgcaaatgg cttctttttg cgctgacgca tcaaagtctg 338341 atccgagcgt atgctggagg atttcttcta cgagcggctt acagcctccg catgagcggg 338401 atgcgccggt gcatgctttg atttcgtccg ttgacgagca gcccttttcc tgtatggctt 338461 gaataatcgc accttttgac acgccgttac agccgcagat gatttcatcg tcgctcatcg 338521 ctgcggttat gcttgtgcct gcttcctggc tgaggggctg taagattgat attttagagg 338581 tttcagagat atcggcttct ttttgaatca tagaaaacag gcgattgcct tcgctgctgt 338641 cgccgaataa aacagcaccg acaatttgat tgcctctcag gacaattttt ttatagatgc 338701 cgtcctgctc atcgaagact ttaatcgctt ttttctcctc tgattcgtta aagtcaccgg 338761 cagagaagac ctcgacgcct gataccttta actgtgtgga gagaacggag ccctcatacg 338821 gttttgtttc gatgccgcac atatgctttg ccagcacttt tgcctgttca tacagcggcg 338881 ccacaagccc gtaggcgatt cctcggtgct cggcacattc gccgaccgcg taaatgtgcg 338941 ggatttcagt ctgcatataa tcgttgacga tgatgccgcg gttaaccgga atgccgctct 339001 cggccccgag cgttgtattt gggcggatgc cgacagccat gacgactaaa tcagcttcaa 339061 tgcttgtgcc atccttgaat cggaggcctt cgacacggtc gtcaccgaca atttcttctg 339121 tttgcttttc aagtaaaaag gtcatacctt gtttttctaa ctcgttttgc agcaggcgtc 339181 ctgccgttgc atcaagctgg cgctccatca ggaatggggc aaggtggatg acggacacgt 339241 ccatgccgag attcagcagt ccgcgagctg cttccaaacc aagtagtcct ccgccgatga 339301 cggcagcttt tttatattgt tttgacgcgg cgagcattgt gtctgtatct tttatgtccc 339361 ggaaagctgt gacgcctttt ttgtctgcgc ccggaatcgg aaggataaaa gggaccgatc 339421 ctgtcgccag gatcaattca tcgtaaggct ggattctgtc tgcatctgtg atgactgttt 339481 tgttttccgt gtccactttg atgactgttt catttgtata caattgaatg ttgttttctt 339541 cgtaccagtc ccaatcgttt aacgtaatat ctttaatatc tgtatcgcct tgaagcactt 339601 ttgacaaaag gattcggttg taattgggat gcggttcggc accgaaaatt gtgatctgaa 339661 actcgtcttt agcaacactc agtatctctt caatggccct taccccggcc attccattac 339721 caacaagaac tagctgtttt tttcccatca gatgatccgc tccttatcaa atgttttttc 339781 cagcgtagca cagcaaaaag gaatatttaa gatacatgtt ataaaatgta acaaaatata 339841 cgaaaagttc taaaaatttt atgaaaaatt taaataggta tgattcggac ggcgcatacc 339901 ttaaaaccgg gcattttaca ggctggatct aaggcttccc cgattaaatc attcacattt 339961 tgagcgtctg cccaatggat gggaacaaaa acggtatctt ttctgatttg ttctgataat 340021 ttgctgcgga cggtgatgct tccccgcggc gattctattt ttaccagtac acggtcctcg 340081 atattgtagg tcgctgctgt ttgcggatgg atctccataa acgattcaaa atgtctcgcg 340141 gcaagggcgg cgctttttct tgtttggacg cctgttaagt agtgagacat gactctgcct 340201 gtcgttaaat aaagcggata atcggctgtc ggcttctctt ttggaacagg tggttcgttt 340261 ggaatcacac ttaatgccgc tttttgatcc ggatgagcaa atgattctgt aaacaagcgc 340321 ccagttccgg gatgatcaga ttccggacac ggccaatgaa tgccgccttc acgtctgagc 340381 ctgccgtatg agatgcctga ataatcggca atcccgcctc ggctcgcttc tctcaattca 340441 ttgaaaatat cctccgctga cgtataagaa aagtagcggc ccttgccgag agcggatgcg 340501 agatcacaaa tgatctgcca atcatgcttt gcttcgccgg ggcatggccg gcttgcttct 340561 cttaatgtca cgcgtccttc tacatttgtc atggtgcctt catcttctaa gtaagaggag 340621 gcaggtaaaa tcacatctgc gtatttcgca gtctcagaaa taaacaaatc gattgcgaca 340681 aagaatgtca gtcttcttaa agcctttttc acgagatttg catttggact ggaaacagca 340741 gggttggagc acatgaggaa cagtcctttg atgtcgccgt cattgatttt ttccatcatt 340801 tcataggctg agacaccttt tcgcgggagt tcatcctgat ggattcccca cactttcgca 340861 atatgcgccc ggtgttcttc gttttcgata gaacggtagc ctggaagctg atcggctttt 340921 tggccatgct ctctggcgcc ttgcccgttg ccttgtccgg tgatcgcccc gtagcccgag 340981 taaggtttgc cgatttttcc tgtgatcagc accatgttta agaagccttt cacagccgct 341041 gttccatcgg tttgctgttc aatcccgcgg gctgtaaaca gcatgccgga cgtttccttg 341101 gcaaacttca cagcagcttt tcttatatcc accagcgaga cactcgtctg ttcggcgatg 341161 tcattcaggt ccaacgagtc agtatgctgc ttcagctctt cgaatccatt tgttcgtgat 341221 tgaatgaaat cctcgtttat aagctgttcg tcaatgatga ttttgacgag accgttggca 341281 agggcggcgt ctgtgccggg tttgattttc agatgaagat cggcgatttt cgttgtcgct 341341 gtttcacgag gatcaatggc aatgaagtaa gctccgtttt ctttcgcttt ttcaaaatac 341401 ggcataatcg taggctggca ttccgcaata ttggtgccgg ccagaatgat cacacgggtg 341461 tgggggatgt ctgataaagg attcgttaag cctctgtccg cgccgaatgt ttggttggct 341521 gcggtggctg ctgcggacat acaaagtctc ccgttgtagt cgatgtattt tgtctgtaag 341581 cctactcgtg cgaacttccc taacaaatac gcctcttcat ttgtaatcga ggcgcttccg 341641 tataccgcca tggcgtcatg tccgtgttca gtttggatca ttgtcacttg gtctttgata 341701 tgattcagtg cttcttccca ggaaacaggc ataaactcgc cgtttttctt cagcagcggc 341761 cgggtgatgc gggaggagtt caaggcatgc tggtgagcat tcatgccctt gatgcatagc 341821 cgaccctgtg tcgtaggatt atcaatcccg atcgcagtgt actttttgcg cgtgacgatg 341881 gtttgttcca cgagctgcat tttgcactgc atgctgcaaa acgggcattg agtgtcatat 341941 gttttttctg attggacgtc ttgctgttta tcacggaaat atctaagcag tcgttcagtc 342001 aaaatgcctc atcctttctt atatgcgccc gtctctacag tcgggttttg aatcagtgac 342061 agatctgttt ggaggctttc cagcagctgt gcccttaggt cttcttcgaa tagcacttct 342121 ctgatatgaa cgatcccgag acggtctatc cactgatgaa caccttctaa gtaatgagcc 342181 gtttcccgat aatactggat cagtcctttg atcatgccgg cagtgctgtc ttcgttctca 342241 gtcacgcaaa acaaagctcc tgaacgggca tgagttcccc ggacgccgcc gatgtgaatg 342301 tcccagccag cttgtgtccg aattgcgccg acatcttgca gggcggcctc ggtgcagtct 342361 gtttcacatg ataagctgat agaaatggga gcgggtaagg gaagcatctc aagttgtctt 342421 tcgatttggg ctgccagctg ctgaatcgat cgattttgcc cgcatgtaca tgctttgatg 342481 ctttgcagcg cgtgtcggtg ttcattagtg taaacgggca ttttcaggtc ttttttcatg 342541 ttcgggagat ccgcaggctt gatcccggaa agcttcagcc tttggccgtg agtgatggat 342601 acgtcgggaa tgctgtatgc ctcaatgatg ttggcgatgg ttcttagctg ctccgcgttt 342661 gtccgcccgc cgtacatttg cggaatcagg atgcatgtct cttcagtggc tggctcaggc 342721 tggacaaacc cagggtacag catttccaga tagtattgaa tcgcaggaac acaagtactg 342781 catccgtttt ttgttttcca gtcaagctgg ttcatcactt ctgccggatt agtgaatggc 342841 ctgcgctgaa gctcagcgat gatgtcgtct tctgtaaaat cagtacagct gcaaaacgaa 342901 ggtgtgctgg cgggcttcgt atattcgctg ttggtcatgt atctcaaaag gtcttcaacg 342961 agcggtttgc atcctccgca ggacccagtg gctttggtgc agtgcttgac ttcctcaaca 343021 gttgttaagc tattcgtgtg caccgcgtct tcaatcgcgc ctttcgtcac tgtgttgcat 343081 tggcaaatcg tttcactgga aggcatggat tcaaataaag ggccgcttgt ctccggttcg 343141 atgatctgtt ttttggcaat ggagatgtct cgttgtttaa gcaggctgtc gagaagccgc 343201 tgcttgtcac gggtgtctcc gaataaaata acgccggcca gtttgtcatc tacaaaaagc 343261 gcttttttat aaacgcctgc ttgttcgtcg tagattttga tgctcgtcgt gcgttcatcc 343321 tcttggatct ttcctgctga ccacacatcg attccagcta tttttaacgc cgcagatggt 343381 gctgagcctt gatattcctc acatggaacg ccgcaaatat gactggcgag cgcttttccc 343441 tgctcataaa gcggagccac caatccgtac accgttccgt tatgctcagc gcattcacca 343501 acggcgtaga tattcggttc gcttgtctgc atgaagtcat tcacgatgat cccgcggttc 343561 actttgattc cagcggatac agccaattca atattcggtt tgacgccggc cgccatcaca 343621 atcaagtctg cttttaatga agagccatct ttaaaatgga ttcggtctgc cttcgtggcg 343681 ccggaaatgg agacggtgtc tttctccaaa agaaaggtta ggcctttttg ttccagctct 343741 gtttgcagca gccgcgccgc tgtttgatcg agctgttttt gcataatgcc ggcggagtgg 343801 tgaatgacgc tgacatccat accgagatgc tgtaaaccta ctgcagcttc cagtcctaat 343861 aagccggctc cgattaccgc agccttttga aagtgctggg ccatgttcat cagcgcttgg 343921 cagtcttcta ttgtccgaaa tccatagaca ccttttttgt ctgccccggg gatagggaga 343981 atatgagggg aggagcctgt tgccactatt aatttgtcat acgacagagt gcgtttccga 344041 tctgtgatga cctgctgctg atctgtatca atctgaataa ccgtttcgcc tgtgtaaagc 344101 gtgatcccgt gcttgtcgta ccaatccttg ctgttcagtg taatatcatc gagtgacgct 344161 tcaccctgca atacagagga taagagaatg cgattgtaat tgggatgcgg ctcgcttccg 344221 aaaatgacaa tctcaaacat gtggcgattc agctttaata cttcttcaat acagcggatt 344281 ccggccatgc cgtttcccgc taacactaat ctttgtttct tcatgtatca gacctccttt 344341 ggcgaagctc gtaagttttc tcctattaaa aattatgtca caatgcattg ttaacgcatt 344401 aaacgtgtca caaaaactta cacatgtctt ttccagaaaa taatggtcct atatccttga 344461 ttcagaaaat gtaaaataat gagggtctag aaaggggaat cttatgaagc tgtcggaact 344521 gaaaactagc ggtcatccac tcactttgct ctgttccttt ttatactttg atgtcagttt 344581 tatgatatgg gttatgcttg gggcgctggg tgtttatatt tctcaggatt ttggcctgtc 344641 tccttttgag aaagggcttg tcgtagctgt gccgatttta tctggatctg tgtttcgtat 344701 cattcttggt attttaacgg acagaatcgg accgaaaaaa acggcagtga tcgggatgct 344761 ggtgacgatg attccgctgc tttgggggac attcggcggc cgttccctga ctgagctgta 344821 tgccatcggg attctgcttg gcgtggcggg agcaagcttt gctgtagcgc tgcctatggc 344881 cagccgctgg tatccgcctc atttgcaggg acttgcgatg gggattgccg gagcggggaa 344941 cagcggcacg ttgtttgcaa ccctgtttgg ccctcgtctg gcagagcagt tcggctggca 345001 cattgtcatg ggaattgcgc taattccatt attgatcgtc tttattcttt ttgtatccat 345061 ggcaaaggat tcccctgcac agccgtctcc ccagccgctc aaaagctatc tgcatgtgtt 345121 tgggcaaaag gaaacatggt ttttctgcct gctgtacagc gtcacatttg gcggatttgt 345181 cgggctctca agctttttat ctattttctt tgttgatcaa taccagctgt caaaaattca 345241 cgcaggggac ttcgttacat tatgtgtggc ggcggggagc tttttccggc ctgtcggggg 345301 cttgatttca gatcgtgtcg gcggcacgaa agttctttct gtattgtttg tcatcgtggc 345361 actgtgtatg gccggagtca gtagcctgcc atctctctca atggttattg ttctattgtt 345421 tgtcggaatg atggggctcg gaatgggaaa cggcgcagta ttccagctcg tgccgcagcg 345481 cttccgcaaa gaaatcggca tggtgacggg aatcgtcggt gcggccggag gaatcggagg 345541 gtttttcttg ccgaacatct taggatctct caaacagatg acaggcacat atgctatcgg 345601 ttttatcacg ttttcctgta tcgcgctgct ggcgtttgca cttgtgcttg ccgcaggcta 345661 ttactggcgg aaaagctgga gcgcggaaag cagcccggcg gatgtttagg attttgacgg 345721 acacgcgttt gtgcgtgtct tttttatttt ctcttgattt tcaacagtga accgatcaaa 345781 ataaatagta attattacga tttgttagtg agaggagttt tctgaatgaa tcaacatacg 345841 ctgctcccga aaaaaacgga gcgtcttcaa tactttggat cggtcagtcc gatcaaaggc 345901 gagaaaccag tggaaaaaga gaaaatgaag gacctgcaaa atatcaggaa ggattatttt 345961 tttgacattc agcatgtagg tgtagctaat gtgtcccatc cagtcacaat cacttctgcc 346021 atgatgcctg ccgagcaaac aacggctgcg aactttacaa tgacttgtaa tttgccgaga 346081 aatcagaagg ggattaacat gagccggtta acagagctgc tgcaagtcta tcatcaaaat 346141 ggctggattc tctcattttc ctctcttcag caatttacga aagagcttgc agaaaacatg 346201 gacacatcat ctgccacagt tgaagtgagg tttccgtggt ttttcgaacg gaaaagcccg 346261 aagcttgaga aagcgggttt gatgcatgct gatatattca tgtctgtcac ctatcgcaaa 346321 gatcagccgt ttaaacagcg tgccggcatc tcagcaaaag taacgactct gtgcccttgc 346381 tccaaggaaa tcagcgaata cagtgcccat aatcagaggg gaacggtcag catttgggcg 346441 gatattcacc cggccgcatc gctgccaagt gatgttaaag ctgatttgct tcacgccgca 346501 gaatcaaatg cttctgcgag actgcatccg gtattgaagc ggcctgatga aaaagccgtg 346561 acagaaacgg cctatgaaaa cccgagattt gttgaggatc tcgcccggct gattgctgca 346621 gatttgtttg agcttgaatg ggtgtcagcc tttgagattg aatgccgaaa tgaagaatcg 346681 atccatcttc acgatgccta tgcgaagctg tgtttttcga aggaagtgga taaaatatga 346741 aactctcatt attcattatt gcagttctta tgccagtcat cctgctgtca gcctgctccg 346801 atcatgcaga agaacacgca agtatcaata caaagaaaac ggtcgaaaac ataacggacg 346861 ttcgaaaaac agcaaaaaca agcattgatt ggacaaagcc ttcgggcgga gaatacccgg 346921 atattaaaca gaagcatgtc tggattgatg tgaatgtgaa ggagcagaag gcttacatca 346981 aggaaggaag caacaccatc tatacaatga tgatttcttc tggtcttgat caaacaaaag 347041 atgatgctac gccaaagggc accttttatg tagagcctga acggggagaa tggtttttct 347101 ccgaaggata ccaggaaggc gcagaatact gggtatcatg gaaaaatcac ggtgaatttt 347161 tatttcatag tgtgccaatg actaaggatc aaaaagtcat caaaacggaa gcagaaaaac 347221 taggaacgaa agcatctcac ggatgtatca ggctgaccat tccagatgcg aaatgggtat 347281 atgaaaatat ccctgaacat acaaaagtgg tgatcagctg aattgaaaac cgttgacaaa 347341 aaggaaaaaa gaccatacaa tttaaatcgt aacaattacg ttttatgata aatggcttat 347401 cattgtctgt gcatctgtga aaagcggaaa ggcatcgatt aaggatcttg ctgtcggcaa 347461 aggcaaggat ttgcgatggg gaaaaggatt aaacgcggtt ggagtcttta ctgatttaga 347521 aatcgggcgg cagcgagaaa tgagcgcgaa aagctgctct acaccattgt acatacggcg 347581 aagtattcaa tttaaatcgt aatcattcta ttttaatgga ggcactatta tgaaaaaaat 347641 tccggttacc gtactgagcg gttatctcgg tgcgggaaaa acaacattgc tgaacagcat 347701 tttgcaaaat cgcgaaggct tgaaaatagc ggttatcgta aacgatatga gcgaggtgaa 347761 cattgacgcg ggcttggtta agcaggaagg tggcctttcc agaacagatg aaaagcttgt 347821 ggaaatgtca aatggctgca tttgctgcac gcttcgcgaa gacttattaa ttgaagttga 347881 gaagctggca aaagacggac ggtttgatta tatcgtcatc gaatcgacag gaatcagcga 347941 accgatcccg gtggcccaga ctttctctta tatcgatgaa gagatgggaa tcgatcttac 348001 aaaattctgt cagctggata cgatggtgac ggttgttgat gccaaccgtt tttggcatga 348061 ttatcagtca ggcgaaagcc ttctggaccg caaagaagca ttgggggaaa aggatgaaag 348121 agaaatcgcc gacctcttga tcgatcaaat tgagttttgc gatgtactga tcttaaataa 348181 atgtgatttg gtcagcgagc aagagctcga acagcttgaa aacgttcttc gtaaactgca 348241 gccaagagcc aggttcattc gttccgtcaa aggaaatgta aaaccgcagg agattttgca 348301 tacagggtta tttaacttcg aggaagcgag cggatcggcc ggctggattc aagagctgac 348361 ggcaggccat gcggaacaca ccccggaaac agaagaatac ggtatctctt catttgtata 348421 taagagacgt ttgccgtttc attctacacg attttaccgt tggttggatc aaatgccaaa 348481 gaacgtggta cgtgccaaag gaatcgtctg gtgcgcatct cataacaacc tcgctttgct 348541 gatgtcgcaa gcaggtccgt cggttacgat tgagcctgta tcttattggg tggcggcgtt 348601 gccgaagctt gagcaggagc aagtcaaaca gcaggagccg gaaatcctgg aggagtggga 348661 cccggagttc ggcgaccgcc taacgcagct agtttttatc ggaactgacc tggatgaaga 348721 aacgatcacg aaagagcttg atcaatgcct gttgactgag tatgaatttg attccgactg 348781 gtcgctgttt gaggacccgt ttaaatggaa gctgaatcaa tagaaaaaaa gccgtcccat 348841 ggggaacggc tttttttaat gaaacgtttg tttaaacata atgagcgtat tttttctcaa 348901 ggatattctg aaagaccgcg gcaatggagc agatggccca ataaatgaga gcggtcagaa 348961 tatacatggt catataatca aactctctgc ccccgatgat tttcgcatgc tggagcaatt 349021 ccggcactgt aatcatcgca gcgagagagg acgccttgat caagtcgagc aatacattgg 349081 caagcggagg cagcgcaata cgtatcgatt gcggcaaaat gatgcccctc atcgtctgcc 349141 aataggaaag acccagcgag gatgcggctt cccactgtcc tttttcgacg gatgaaatgg 349201 ctgaacggtt aatttccgca atgtaggcgg cgctgtttag gctaaagccg attaaagcag 349261 ccgtgacagc ggaaaattca atgccgatat aaggaaaccc gaaataaagg ataaacaaaa 349321 tcaccaaaat cggaacgcct cgcataaatg agatatagag cttcgccggc catcttaaca 349381 aagcaagttt agacattctg gcgagtgata tgaacaggcc gatcacagtt cccgcaaaca 349441 tgcttacaaa agagatgagc agtgtataac caatgccttt tatgacataa gggaacgatt 349501 caatggccag cttcgtgttg aaaatatatt cccactgaat gctattgatc atggcgtccg 349561 attacaaatc aacgtcctga acgtcggcat caattttttt tgatacatct gctttattga 349621 agaattgttt cgacagttta gtcaaagagc catccttgct catctctttc aatgcttcgt 349681 tcatcttttt ctgaagtgcc gcattgcttt ttttcatgac aagggcctgt ttgttcggca 349741 tgtacttgat gtcaggatga attgtaatgt tgagatccgg gaatgccgcg agcgcaagtg 349801 tctgcaggta atagtcgttt aaaatgacgt cagtgcgtcc gttggcaaca tcttttaaat 349861 attgctcatt cgtcgcatta tcataaatca cttctttggc gccgtatttt ctcgcgacct 349921 ccatgtagac ggttgtagcc gcgccagccg ctttcttccc ttttaaatcc ttgagcgttt 349981 taatccctga taaatcgtct tttcggacaa ttgccgtgcc gtatgaatat ttatatggag 350041 tggaaaatgc gaacttctcc tcacggtcct tcgtcacatc gatgtcattc gcggctgcgt 350101 caacctgtcc gctgttcacc gctgtcagca tcccgtcaat gcccatctcc ttgaactcaa 350161 ccttcagccc caagcgtttt gccgcttcac gaacaacttc aacctcgtag cccgtcagct 350221 tatcagagcc agagtcagta tcgtgataag aagtgggata gagcgtacct gatgtagcga 350281 ctacgatttt ccctttatcc ttaatctgct cccagcctgt atccttggaa tcggcttcat 350341 ttttgccgga acaggctgcc aatataagaa agaaagccat tgtgaaactg aatataacgg 350401 ctttggaatg catgaatgat ttcacctata gttcccccaa tctgttaatc aactaaaaag 350461 atagcattga acataagggg ttgcaatatg ttgatcgcgt tttcaaaaag ttcgaattgt 350521 gtatacaaaa agcatgggtg ggtgtttaaa agcgtctatg aagggaagag gtgatgaaaa 350581 aaggaattgt ccaaggatga atgccagacg taccaaggaa acgcatgtga aagtgaagga 350641 tgcagcagac ccgtcactca tctatgccaa taccggaaga aatggtcaag aggcatgaaa 350701 ccgatcttca gaataaattt aagtcttgct gatgccccta aggcatatga tatattcgat 350761 gagaaagaaa atggaaacat ttaaaccata atggggagtc aaatgaatat ttacaaacca 350821 gccggatttt ggatcagact tggagctgca ttgttagact acattatagt ctccgtgccg 350881 cttttgctga tctattggct gattacagga aaagacccaa acgacagcat gttcatcagt 350941 ttggttgttc tgctgtattc tattttgctg ccgatgtttt ggcgcggtta tcttatcgga 351001 aaaaggatct gcggaatcag aatcgtaaaa aaagacggat cacaggtcag tctgttaaca 351061 atgtttttac gggttattgt agccggcctg gtttactgta taaccttcgg actcggcttg 351121 atcgccagcc tgattctgat tgccgtacga gaagacaaac ggaccctgca tgatttaatc 351181 gcgggaacat atgtcactta tgcgacacca ggtgaagagg aacttaatgc tgacgaagag 351241 attagaaaga gcgaataatg gttcgctctt tttattttta tgcataaaaa atacaaggca 351301 gcaaaacata tgaaaaatag gattggagga ataaaatgga tgaaacgaat aaccatcaac 351361 attatcacaa tgttcattgc agcggctgtc atttctctga ccggtacagc tgaggccgct 351421 gaaaaacagc agcagtctcc cgcaaatgtt acactgacag atcagcaaaa gaaagagatt 351481 gaacaactgg aagcagagat tcttaaaaag cgcaaagacg tgatctcaaa gtatgtacaa 351541 tacggtatcc tgcctaaaga aagaggagaa cacatcaaaa atcacttgga caaacacttt 351601 gaaatgatga aacaaaacgg ctttgttcca aagcaccatc ctcatccgca taaatttgaa 351661 aaaagacatt aagattttaa gcatccaatg ggaattgggt gcttttgcgt tatttacagg 351721 taggcaatat tagctgagct gttccgcgac taacatcgag ttgatatgaa acgcgtttca 351781 tagcctatga taggtttatc aaataattca ggagtgataa acactatgat ccaccagcat 351841 ccagaatctt ttccgaaaca ttttttgtgg ggctctgctt ctgcagcgta ccagattgaa 351901 ggcgcttgga atgaagatgg caaaggccct tctgtttggg atgtgtttac gaaaataccg 351961 ggcaaaacgt ttaaaggaac caatggcgag attgcggttg accattatca ccgatttaaa 352021 gaagatgtcg ctctgatggc tgagatgggg ttaaaagcat atcgattttc cgtcagctgg 352081 ccacgggttt ttccaaaagg aaaaggagag atcaatgaag caggtctagc gttttacgat 352141 agtctgattg atgaattgct ttctcatcac atcgagccgg ttctgacttt atatcactgg 352201 gatttgcctc aagcgcttat ggacgaatac ggcgggtttg aatccagaaa catcatagag 352261 gattttaatc actactgtat tactctttat aaacgttttg gagacagggt gaaatattgg 352321 gttacgttaa acgaacagaa ctacaatttt aatcacggat ttattacagc catgcatccg 352381 cctggagtga aagacagaaa acgattttac gaagcaaacc atattgcgtt tctggctaat 352441 gcaaaagcca tcgaatcatt tagagaatat gtgcctgaag gcaaaatagg tcctagcttt 352501 gcttattctc cggcttaccc tttatcaagt catccagagg atatactggc atttgaaaac 352561 gccgaagaat ttacgaacaa ttggtggctt gacatgtatt gctggggaac ctacccgcaa 352621 attccattcc gctgcttgga aaaacaggga tgggcgccga caattgaagc aggagatatg 352681 gacctgctcg ccaaagggaa gcctgatttt gtaggtgtca attattatca gacgatcacc 352741 tatgaacgaa atccgcttga tggtgtgtca gaagggaaaa tgaatacgac aggccaaaag 352801 ggaaccaatc aggagacggg gatacccgga gtgttcaaaa cgaaaaaaaa tccgcatctg 352861 acaacgagca actgggattg gacaattgac ccaattgggc tgcgtatcgg tcttcgccga 352921 attacaagcc gctatcagct tccagtgttt ataacagaga acggtttggg tgaatttgat 352981 aaagttgagg acggcactgt acaggatgat tatcgaattg attatttgcg ttcgcatctt 353041 gagcaatgca gacaagccat cagtgacggt gtcgatttaa tcggctattg cagctggtcg 353101 tttactgatc tgttaagctg gctgaacggc taccaaaaaa gatacggatt tgtatatgtc 353161 aatcgtgatg aagaaagcac atccgattta aaacgcttga agaaaaaaag cttttattgg 353221 tatcaagatg tcatcaagac aaacggagaa agtttataaa gagtccctga gagttattct 353281 ctcaggggtt tttcattaca cagaaacagc atcaataata taagtgtcgg cgtgcaaatc 353341 tgacatttca gccggcacag tccagcatgt caattgatag tctcctttag gcagatcaaa 353401 ggacagtctt ttagacatga tgctttcaat atgaattccg ttttctgtga catgaaaagg 353461 aacagtcact tttttttcgt aggagtttac tgtttctgaa ctgttcaggc gaaaaagaat 353521 aaaggccttt gtatttcgct gtgcctcaaa ggaaatggct ccgtctgccg cagcatatcc 353581 tttttcaatc gcttcgtcag tccaatccat tacaggaggt gtagaatcct tttgaaatac 353641 agtaaattga tgatatgaaa tcgaaagttc ttgcggcttc catgatttga tcaatgtgct 353701 gttcctcctc tatgtactgt ttactgaatt gtgaataaaa cctttgtgcc gtctgggtaa 353761 tcggtaagcc gatgcccgac ccaagagcct gctccgcggt tgtcagcggg agaaatgtat 353821 tctacagaag ctccctcacc gccttctttg cacatggcca ttggccattc atctctgtca 353881 tacccctttt tggaaggtac gtcctttaat gattgctcgc ggcgttcttc agctccgtct 353941 ctgtcaatag tgcacacctc tgagtgcccc tcatttatcg catccttaat atgcttggca 354001 gtttcgggat accggtcaga tgggaaggcc attgtttcat catattcttt cgtttgagac 354061 gttttttgat cagctgagaa aaagtctcct tttatcaggc cgacagctgc agctgctatg 354121 atgacgatga cgagaagtat cgtttttatg atgtccgtcg tgatgttcac ctcccgcttt 354181 taaaactgac acaagagtaa tccagaaagc atttggtgta aaggtttaaa ttttatgttt 354241 tacgatcagt ttattgcaga aatcgtaatt ttagcagatc gaaatatttg ttttcagcaa 354301 aatacgattg ccaatttaca ataatgatag taagtcatca gccgttttcg gcttgattaa 354361 tcattttaaa ttggcttatg ataccggtaa gctcctcagc taattgagaa agtgtttcag 354421 aagctgcggt aatctcctcc attgcagcaa attgctcctc tgttaatgca gccgcttgcc 354481 gggtattttt agtagattct ttaatgtcgg ccgtattggc tgcaaaggaa tcatttattt 354541 gatgtgcact ggctgaaatg tttgttacag atgctgataa atcactaatc tcggcgctga 354601 tttcacctgt tgcagctgca atttccttaa atgcatctct ggtgcgctgg atcatggtga 354661 ctccttctgc agcttctgtt ttcacatgct caacagatct tgcagaccgg ttcatatcct 354721 tttgtatttc tatgatcagt tttgaaatct gccccgcaga ctgttgagac tcttctgcta 354781 atttccgtac ttcatcagca acaacagcaa agccttttcc ttgttcaccg gctctggcag 354841 cttcaatcgc tgcattcagc gcaagcaggt ttgtctgatc agcaatttgg gtgatgaccg 354901 ataaaatttg ctcaatttgt ttagagcggc cgtctaactg gtgtatgatt tctccgcttt 354961 tctgaattga ctggtgaatc gcatccattt gcgcctgtac atttgcaatt tccttttgtc 355021 caatgtctgc ttttgattga gcgagctgcc ctttgtcagc gatagcggca gtatttgcag 355081 aaatatcccg gatgtctgct gaagcttgtt ttaatgagct ttcactattt tcaattcggg 355141 tgatctgatc ttgggctcca tttgcaatct gctgtacagc ttctgtgatt ttttctgaag 355201 cttgatttgt ttcctctgct ccggctgaga gctgctgaga ggctgacgca agctgaaggg 355261 ctgattgttg tacggtttgt atggtatcgt tcagcttcat tctcatctta ttataataga 355321 cgcttagttc tgaaagctcg tcaccggttt tgtctgacac ctctattgtc atatctccgt 355381 ttccggcact ttcaaaggcg ctttttaaag cgttcagccg cttgttgatt tttctggtga 355441 aaaccaagac aaggatgact gataccataa tgacgataac aagaacgata gcgaattgag 355501 tgaaaagtga ttgtgtaagt gatgctaaaa tactttgatt agctccggta tacagcatgc 355561 cgatgatgtt cccattttga tcttttaacg gcatgtatgc agtctgataa gaagaacctg 355621 ctacatctgc ttgtccgtaa aaacgctttc ctttctttaa aacagcggca ataacttcag 355681 aagaagcctg ggtgccgacg gctctttcgc catttttcat gacattggtt gcaacacgag 355741 tatcgccttg gaaaatggta atggtatcac ctgtcttttc accaagcaga tcaacaatat 355801 cttcatttcc attgatttgt gtttgccctt tatagagctt attgtttttc acctgccagt 355861 cgcctgacat gacatcatca atataagtgc tgcttaaagc gagatcacct ttcgcttttt 355921 cagttgccat ttgtttcatg ctttctgtaa tttccttaag catcacagtg ccaactgatg 355981 ccgaaaacaa aagaatcacc acgaaaacga ggcaaagaat tttagttcct agcttcatct 356041 taaatcgttt tatcaacata attcctccct ttacgatttg caggtcatat tacttatcgg 356101 gtttttgggt ttaaagtttt attttagaaa aaataaaacc ggcctgatct tcaggccggt 356161 tgtgtgatgc tattcaaggt ttgcgtggtg agtgaacata gtttcagaat cgagaccttt 356221 tttctccatg agttttaaaa tcactgcatc atagaagagc agcaaagttt gttcaaataa 356281 tgatcccatt ggctgaatgg ttttatagct tccgttagac tggtctttag gggaaccagg 356341 cattctgatg atgaggtccg cttgttttcc gatgcttgat tccggattga tggttaaagc 356401 ggcaacaatt ccgtgtaagc tttttgcttt tgctgcggta tgaatcaagc tctttgtctc 356461 gcctgatcct gagccgataa taactagatc tccttcggcg agcggcggag tgagaatctc 356521 acctactata tgggcgttga agcccatgtg catcagtctc atcgcgaagg attttgccat 356581 caggccagac cgccccgcac ccgcggtgaa aatttggtgg gatgaaagaa tgtgatcggc 356641 aagctggtca gcttcttcat tagaaatata agctgctgaa ttgtgtaact cattgagaat 356701 ttccgctacg tattcagtcg ttttcatcgg agttatcctt ggacaatcag ctgcttcatt 356761 tttgaagctg tttccgcctt atcagctgcg cttgtaattc cgcccccgac aatgacaagg 356821 tcaggctttt gctggatcac ttctggcagt gtatcaagtt tgatgccgcc cgcgattgcg 356881 gtttttgcgt tttttacggt atttttgatt gtcgttaatt cttcgaaaga gtttttgccc 356941 tctgcttgaa gatcatagcc agtgtggacg cagatgtagt caacaccgag tgcgtcaatt 357001 tctttcgcac gggattcgat atctttcacg ttaatcatgt ccactaagat tttcttcttt 357061 tgttttttgg cttcttctac tgcgccttta atcgttgcat cgtctgtagc ccctaaaacg 357121 gtgatgatgt cagcgcctgc ttccgacgct ttcataattt cgtagcctcc ggcatccatg 357181 attttcaggt ctgcaagaac cttcaattga ggaaatgctt cttttatttc tttaacggct 357241 cttaggcctt cattgatgac gaccggtgtt ccgatttcaa ctacgtcgat gtattgttct 357301 acctctttga caagctcaat ggcttccggg atgttgacga ggtctaatgc aagctgtaat 357361 tccattgttg atccactccc tttttcgaat tattgttcat tctataggtt ccttcttttg 357421 ttgagaagta ggcactttga agtcaacaag ttacttggag gatactgtga ggagagacaa 357481 tcagatttct ttcgcttgat tttatgagtg agtataatga aaaaagagtc tgcaaaaaag 357541 taagtaagtg atgatacgta tctaacatac aaaaaggtta ctaagggggg ggattctatt 357601 gagccggatg gacgacaaaa ggtttaattg tgagaaggaa ttaacgcttg cagtgattgg 357661 cggtaaatgg aaaatgctca ttttatggca tttaggaaaa gaaggcacaa aacggttcaa 357721 tgaattaaaa acattgattc ctgatattac gcagaagatc ctcgtgaatc agctgagaga 357781 gcttgagcag gatatgattg ttcacaggga agtgtatcca gttgtcccgc cgaaggttga 357841 atattctctg accccgcacg gagaaagcct catgcctatt cttgaagcca tgtatgagtg 357901 ggggaaaggc tatatggaat tgattgatat cgacaaaaat gtcatgaaag aatcgttgta 357961 agacgctctt cgcaagggtg tctttttttg cctttttttc ggtttttgcg cggtacacat 358021 agtcatgtaa agattgtaaa ttgcattcag caataaaaaa agattgaacg cagcagtttg 358081 gtttaaaaat ttttattttt ctgtaaataa tgtttagtgg aaatgattgc ggcatcccgc 358141 aaaaaatatt gctgtaaata aactggaatc tttcggcatc ccgcatgaaa cttttcaccc 358201 atttttcggt gataaaaaca tttttttcat ttaaactgaa cggtagaaag ataaaaaata 358261 ttgaaaacaa tgaataaata gccaaaattg gtttcttatt agggtggggt cttgcggtct 358321 ttatccgctt atgttaaacg ccgcaatgct gactgacggc agcctgcttt aatagcggcc 358381 atctgttttt tgattggaag cactgctttt taagtgtagt actttgggct atttcggctg 358441 ttagttcata agaattaaaa gctgatatgg ataagaaaga gaaaatgcgt tgcacatgtt 358501 cactgcttat aaagattagg ggaggtatga caatatggaa ataacttttt accctttaac 358561 ggatgcacaa aaacgaattt ggtacacaga aaaattttat cctcacacga gcatttcaaa 358621 tcttgcgggg attggtaagc tggtttcagc tgatgcgatt gattatgtgc ttgttgagca 358681 ggcgattcaa gagtttattc gcagaaatga cgccatgcgc cttcggttgc ggctagatga 358741 aaacggggag cctgttcaat atattagcga gtatcggcct gttgatataa aacatactga 358801 cactactgaa gatccgaatg cgatagagtt tatttcacaa tggagccggg aggaaacgaa 358861 gaaacctttg ccgctatacg attgtgattt gttccgtttt tccttgttca ccataaagga 358921 aaatgaagtg tggttttacg caaatgttca tcacgtgatt tctgatggta tctccatgaa 358981 tattctcggg aatgcgatca tgcacattta tttagaatta gccagcggct cagagacaaa 359041 agaaggaatc tcgcattcat ttatcgatca tgttttatct gaacaggaat atgctcaatc 359101 gaagcggttt gaaaaggaca aggcgttttg gaacaaacaa tttgaatcgg tgcctgaact 359161 tgtttccttg aaacggaatg catccgcagg gggaagttta gatgctgaga ggttctctaa 359221 agatgtgcct gaagcgcttc atcagcagat tctgtcgttt tgtgaggcga ataaagtcag 359281 tgttctttcg gtatttcaat cgctgctcgc cgcctatttg tacagggtca gcggccagaa 359341 tgatgttgtg acgggaacat ttatgggcaa ccggacaaat gcgaaagaga agcagatgct 359401 tggcatgttt gtttctacgg ttccgcttcg gacaaacatt gacggcgggc aggcgttttc 359461 agaatttgtc aaagaccgga tgaaggatct gatgaagaca cttcgccacc aaaagtatcc 359521 gtataatctc ctaatcaacg atttgcgtga aacaaagagc tctctgacca agctgttcac 359581 ggtttctctt gaatatcaag tgatgcagtg gcagaaagaa gaggatcttg cctttttgac 359641 tgagccgatt ttcagcggca gcggattaaa tgatgtctca attcatgtaa aggatcgatg 359701 ggatactggg aaactcacca tagattttga ttaccgcact gatttatttt cacgtgaaga 359761 aatcaacatg atttgtgagc gcatgattac catgctggag aacgcgttaa cgcatccaga 359821 acatacaatt gatgaattaa cactgatttc tgatgcggag aaagagaagc tgcttgcgag 359881 ggccggcggt aaatctgtga gctaccgtaa ggacatgacg ataccagagc tgttccaaga 359941 aaaggctgaa ctgctttctg atcatccagc ggttgtattt gaagatcgca cattgtccta 360001 tcgaacgtta catgagcaat ctgcacgcat cgccaatgtg ctgaaacaga aaggggttgg 360061 cccggacagt cctgtcgcgg ttttgattga acgctctgaa cggatgatta cagctatcat 360121 gggaatttta aaagccggcg gagcctatgt gccgattgat ccgggttttc ctgctgagcg 360181 cattcaatat attttggagg actgcggggc ggatttcatc ctgactgaat cgaaggttgc 360241 ggcgcctgaa gccgatgctg agctgattga cttagatcag gcgattgagg aaggtgcaga 360301 agaaagcctg aatgcagatg tgaacgctcg gaaccttgcc tacattattt acacatcggg 360361 aacaaccgga cgcccgaaag gcgttatgat cgagcatcgc caggttcatc atttggttga 360421 atctctgcag cagacgattt atcaaagcgg cagccaaacc ctgcggatgg cattgcttgc 360481 gccgttccac tttgatgcgt cagtgaagca gatcttcgcg tcgcttcttt tgggccaaac 360541 cctttatatc gtaccgaaga aaacagtgac gaacggggcc gcccttactg catattatcg 360601 gaagaacagc attgaggcga cggacggaac accggctcat ttgcaaatgc tggcagcagc 360661 aggcgatttt gaaggcctaa aactgaagca catgctgatc ggaggagaag gcctgtcatc 360721 tgttgttgcg gacaagctgc tgaagctgtt taaagaagcc ggcacagcgc cgcgtttgac 360781 taatgtgtac gggccgactg aaacgtgcgt tgacgcgtct gttcatccgg ttatccctga 360841 gaatgcagtt caatcagcgt atgtgccgat cgggaaagcg ctggggaata accgcttata 360901 tattttggat caaaaaggcc ggctgcagcc tgaaggcgtg gcgggtgagc tttatatcgc 360961 gggagacggt gtgggccgag gctatttaca tttgcctgaa ttaacggaag agaagttttt 361021 acaagatcca ttcgtgccgg gcgatcgcat gtaccggacc ggggacgtgg tgcgctggct 361081 tccagatgga acaatcgaat atttaggcag agaggatgac caggtcaaag tccgcggata 361141 ccggattgag cttggggaaa ttgaagccgt gattcagcag gcgccagacg ttgcaaaagc 361201 cgttgttttg gcacgccctg acgaacaggg aaatcttgag gtttgcgcat atgttgtgca 361261 gaagcctgga agcgaatttg cgccagccgg tttgagggag catgcggcca gacagcttcc 361321 tgactatatg gtgccggctt actttacaga agtgacagaa attccgctta caccaagcgg 361381 caaagtcgac cgccgcaagc tgtttgcact agaggtgaag gctgtcagcg gcactgccta 361441 tacagcgccg cgaaatgaga ctgaaaaagc aatcgcagcc atttggcagg acgtgctgaa 361501 cgttgagaag gcggggatct ttgacaattt ctttgaaact ggcggacatt cattaaaagc 361561 catgaccctt ttaacaaaga ttcataagga aacaggcatt gagattccgc ttcaattttt 361621 gtttgagcat ccgacgatta cggctcttgc agaggaagct gatcacagag aaagcaaagc 361681 ttttgcggtg attgaacctg ctgaaaaaca ggagcattac ccgctttcat tggcacagca 361741 gcgaacatat atcgtcagcc agttcgagga tgcgggagtc ggctataaca tgccagcagc 361801 agcaattctg gaagggcctt tagatattca aaagctggag cgcgcatttc agggattaat 361861 ccgacgccac gagtcattga gaacatcatt tgttcttgaa aacagcacgc cgagacagaa 361921 aattcacgat agcgttgatt tcaacatcga aatgattgaa agaggcggcc gctcagatga 361981 ggcaattatg gcttcattcg ttcggacatt tgatttggcg aaagctccgc tgttcagaat 362041 cggtttgctg gggcttgaag agaaccgtca tatgctgctg tttgacatgc accatttgat 362101 ttctgacggt gtatccattg gcattatgct ggaggagtta gcacgcattt ataaaggcga 362161 acagcttcct gatcttcgtc tccagtataa ggactacgct gtatggcaaa gcagacaggc 362221 tgctgaaggg tacaagaagg accaggctta ttggaaggaa gtctttgcag gcgagctccc 362281 ggtgcttcag cttctgtccg attacccaag accacctgtt caaagctttg aaggggatcg 362341 ggtgtcaatc aagctggatg cgggggtaaa ggatcgcctc aatcgtttgg ctgaacaaaa 362401 cggcgccact ttatatatgg tgatgctttc cgcttactat acgcttttgt caaagtatac 362461 ggggcaggat gacatcattg tcgggacacc gtcagcgggc agaaatcact ccgatacaga 362521 gggcattatc gggatgttcg tcaatacgct tgcgattcgc agtgaggtga agcagaatga 362581 gacgtttacc caattgatct cgcgtgtccg caaacgggtg ctggatgcct tttctcatca 362641 ggactatccg tttgagtggc ttgttgaaga tttgaacatc ccgcgtgatg ttagcaggca 362701 tccgctgttt gacacgatgt tcagccttca aaacgcgaca gagggcattc cggctgtcgg 362761 cgatctttcc ttgtctgttc aagagaccaa tttcaagatt gccaaatttg atttgacggt 362821 gcaggcgaga gaaaccgatg aaggcattga gattgatgtg gattacagca caaagctgtt 362881 taaacaaagc acggcagaca ggctgcttac gcattttgcg cgtttgcttg aagatgctgc 362941 ggctgatcca gagaagccga tttctgagta taagcttctt tctgaagagg aggctgcttc 363001 gcaaattcag cagtttaacc cgggcagaac accttatccg aaagataaaa caattgttca 363061 gctgtttgag gagcaagcgg cgaatacgcc agaccacact gcgcttcaat atgaaggcga 363121 atcactcact tatcgtgaac tgaatgaacg ggccaatcgt ttagcccgcg gcattctttc 363181 tcttggagct ggcgaaggca gaactgcggc tgtcttatgc gagcggtcaa tggatatgat 363241 tgtgtcgatc ttggcagtat taaaatcagg ttcggcttat gttccgatcg atccggaaca 363301 tccgattcag cggatgcagc atttcttccg tgacagcgga gcaaaggtgc ttctcactca 363361 gaggaaatta aaggctttgg cggaagaagc ggaatttaag ggcgttatcg tgctagccga 363421 tgaggaagaa agctatcatg ccgatgcgcg aaatctcgca ctgcctcttg attctgcagc 363481 aatggccaac ctgacgtata cttccggaac gactggaaca cctaagggga atatcgtgac 363541 acatgccaat attctccgca cggtgaagga aacgaattat ctcagcatta cagaacagga 363601 tacgattctc ggtctttcca attacgtgtt tgacgcgttt atgttcgata tgttcggctc 363661 tttgttaaac ggagccaagc tggtgctgat accgaaggaa accgttttgg acatggctcg 363721 cctgtcccgc gtcattgaac gggagaacat cagcattctc atgattacaa ccgctttgtt 363781 ccacttgctt gtggacttga atccggcatg cttgtcaacg cttcgcaaga ttatgtttgg 363841 cggggaacgg gcttcggttg agcatgtcag aaaagctttg caaacggttg gaaagggcaa 363901 gctccttcat atgtatggac cgtctgaaag cacggttttc gcgacgtatc atccggttga 363961 tgaattggag gagcacacgc tgtctgttcc gattggaaaa ccggtcagca atacggaagt 364021 atacattctt gaccgtacgg gacacgtgca gcctgccggg attgccggag agctttgcgt 364081 cagcggcgaa ggactcgtga aaggctatta caaccgtcca gaactgactg aggagaaatt 364141 tgttccccat ccgtttacat ccggcgaacg catgtataaa acgggagacc ttgcgagatg 364201 gctgccgaat ggcgacatcg aatttatcgg gcgaatcgac catcaggtga agattcgcgg 364261 acagcgcatc gagcttggag aaatcgaaca tcagctgcaa acccatgatc gtgttcagga 364321 aagtgttgtg cttgccgttg atcaaggagc gggagataaa ctgttgtgtg cttactatgt 364381 cggagaagga gacatctcat cacaagagat gagagagcat gctgcgaagg acttgccggc 364441 atatatggtt cctgcggtgt ttatccaaat ggacgagctg ccgctgacag ggaacggaaa 364501 aattgaccgg agagcgctgc cgattcctga tgccaacgtt tcaagaggtg tttcatatgt 364561 tgcgccacgc aatggaacgg aacaaaaagt cgcggacatt tgggcacagg tacttcaggc 364621 agaacaagtc ggcgcttatg accacttctt tgacattggc ggacattcat tagcaggcat 364681 gaagatgctt gccttggttc atcaggaact gggcgttgag ctgtcactca aggatctctt 364741 ccagtcaccg acggttgagg gcttggcaca ggtgattgcc tctgctgaaa aagggacagc 364801 cgcaagtatc agcccggcag agaaacaaga tacgtatcct gtttcttcac cgcaaaaacg 364861 gatgtacgtg cttcagcagc ttgaggatgc gcaaacgagc tataacatgc cggcggttct 364921 gcgcctgaca ggtgagcttg atgttgaaag gcttaacagc gtcatgcagc agttaatgca 364981 gcgtcatgaa gccttgagaa ccacgtttga aataaaagat ggagaaacgg tgcagcggat 365041 ctgggaagag gctgagtgcg agatagccta tttcgaagcc ccggaagaag agacagagcg 365101 gatcgtttct gagtttatta agcctttcaa aatcgaccaa cttccactgt tcagaatagg 365161 gcttatcaag cattcagaca ctgagcatgt gctgctgttc gatatgcatc atattatttc 365221 tgatggtgca tctgtcggtg tgctgattga ggagctttca aagctgtacg acggagaaac 365281 ccttgagccg ctccgtattc aatataagga ttatgccgtg tggcagcagc agttcattca 365341 gtctgagctt tacaagaagc aagaagagca ttggctgaag gagctggacg gagagctgcc 365401 ggtgctgacg cttccgactg attacagtcg gcctgccgtt caaacatttg agggagaccg 365461 cattgcattt tcattagaag caggcaaagc tgatgctctg cgcaggcttg caaaagaaac 365521 ggattccacg ctttacatgg tgcttctggc ttcatacagt gcgtttttat caaaaattag 365581 cgggcaagac gatatcatcg tcggttcacc tgtggccgga cgatctcaag cggacgtcag 365641 ccgcgtcatc ggaatgttcg tcaatacatt ggcgctgcgc acgtatccga agggtgaaaa 365701 gacgtttgct gactatctta acgaagtgaa agaaacggca ctcagcgctt ttgatgcgca 365761 ggattaccca cttgaggatt tgatcggaaa tgttcaggtt cagcgtgaca caagcagaaa 365821 tccgttattc gatgcagttt tttcaatgca aaatgcgaat ataaaggatt taacaatgaa 365881 agggattcag cttgagccgc atccgtttga acggaaaaca gccaagtttg acctcacgct 365941 gacggctgac gaaaccgacg gagggcttac attcgtactc gaatacaata cagctctgtt 366001 taagcaggaa acgattgaac gatggaagca atattggatg gagcttttag atgcagttac 366061 tgggaacccg aaccagccgc tttccagcct gtcactggtc accgagacag aaaagcaagc 366121 gcttcttgag gcatggaagg gcaaagcgct gcctgtgccg acagacaaaa cggttcatca 366181 gctattcgaa gagactgccc agcgccacaa agaccgcccg gctgtcacat acaacggcca 366241 gtcttggacg tacggcgagc tgaatgcgaa ggcaaaccgt ctcgcgcgga ttctgatgga 366301 ctgcggcatc agcccggatg accgcgtcgg cgttctcacg aagccgtcgc ttgaaatgtc 366361 cgccgcggtg ctcggcgtct tgaaagccgg agcggcgttt gtgccgattg atcctgacta 366421 tccggatcag cggattgagt atattttaca ggacagcggc gcgaagcttc tcttgaaaca 366481 ggaaggcatt tcagtgccgg acagctatac gggagatgtc attcttctcg acggaagccg 366541 cacgattcta agcctgccgc ttgatgaaaa cgacgaggaa aatccagaaa ccgctgtaac 366601 cgcggagaac ttggcgtaca tgatttacac gtctggaacg accggacagc cgaagggtgt 366661 catggtcgag caccatgcgc ttgtgaacct gtgcttctgg caccacgacg cgttcagcat 366721 gacagcggag gaccgcagtg cgaagtacgc gggctttggg ttcgacgctt ccatttggga 366781 gatgttcccg acctggacga tcggtgccga acttcacgtc attgaggaag cgatccgcct 366841 cgatatcgtc cgcctgaacg attattttga aacgaacggc gtaacgatca cgttcctgcc 366901 gacacagctt gcggaacagt tcatggagct tgagaacaca tcacttcgcg tattgcttac 366961 tggaggagac aagctgaagc gcgcagtgaa aaagccgtac acactcgtca ataactacgg 367021 gccgacagag aatacggtcg ttgccacaag cgcagaaatc catccggagg aaggctcgct 367081 ttccatcgga agggccattg ccaatacgag agtatacatt ctcggcgagg gcaatcaggt 367141 gcagccggaa ggcgtagccg gagagctttg cgtggcgggg cgcggactgg cacgcggcta 367201 tctgaatcga gaagacgaaa ccgcgaagcg gtttgtcgct gatccgtttg tgccgggtga 367261 gcgcatgtac cgcaccggcg atttggtgaa atggacgggc ggcggcatcg aatacatcgg 367321 ccggatcgac cagcaggtca aggtccgcgg ctaccggatc gagctctcag aaattgaagt 367381 ccagctcgcc cagctttctg aggtgcagga tgcggcggtg acagctgtca aagataaagg 367441 cggcaacaca gcgatcgcgg cgtatgtcac accggaatca gctgacatag aagcactgaa 367501 atcagcactg aaggaaaccc tgccggatta catgatcccg gcgttctggg tgacgctgaa 367561 cgagcttccg gttacggcaa acggcaaagt ggaccgcaaa gccttgcctg agccggacat 367621 cgaagcggga agcggagaat acaaagcgcc gacgaccgac atggaagagc tgcttgccgg 367681 catctggcag gacgtgcttg gaatgtctga agtcggtgtc accgacaatt tcttctcgct 367741 tggcggagat tccatcaaag gaattcaaat ggcgagccgc ttgaaccagc acggctggaa 367801 gctggaaatg aaagatctct tccagcaccc gacgatcgaa gagctcaccc agtacgtaga 367861 gcgtgccgaa ggcaaacagg cagaccaagg cccggtggag ggcgaagtca tcctgacgcc 367921 gatccagcgc tggttctttg aaaagaactt cacgaacaag caccactgga accaatctgt 367981 gatgcttcac gccaagaagg gctttgatcc tgaacgggtg gagaaaacat tgcaggcgct 368041 gatcgagcat catgacgcgc tccgcatggt ctatcgtgag ggacaggaag acgtcattca 368101 atacaacaga ggtcttgaag ctgcttcagc tcaattggag gtcatccaga ttgagggcca 368161 agctgcagat tacgaagacc gaatagagag agaagcggag cgtttgcaaa gcagcatcga 368221 cttgcaggaa ggcggcttgt taaaagcagg cttgttccaa gcggaagacg gagatcactt 368281 gcttcttgcc attcaccact tagtggttga cggcgtgtcg tggcggattt tactggagga 368341 tttcgccgcg gtatatacac agcttgagca aggcaatgaa ccggttctcc cgcagaaaac 368401 acattcattt gcagagtatg cagagagatt gcaagacttc gcgaactcca aagccttttt 368461 gaaagaaaaa gagtattgga gacagcttga agaacaagct gttgcggcaa agcttccgaa 368521 agaccgcgaa tctggtgatc agcgaatgaa acatacaaag acaattgaat tctcgctgac 368581 tgctgaagag acagaacagc tcaccacaaa ggtgcatgag gcatatcaca cagaaatgaa 368641 tgatattttg ctgacggcat tcggattggc aatgaaggag tggacgggtc aagatcgagt 368701 aagtgttcat ttagaggggc atggacgtga agaaatcata gaagacctga ccatttctcg 368761 cacagtcggc tggtttacaa gtatgtaccc aatggtgctc gatatgaagc atgcggatga 368821 tctgggctac cagctgaagc aaatgaaaga agatatcaga catgtgccga ataagggagt 368881 cggatacggc attctgcgct atctgacggc accggaacat aaagaagatg tggcgttctc 368941 gattcagccg gatgtcagct tcaactattt aggtcagttt gacgaaatgt cggatgcagg 369001 tttgtttacg agatcagagc tgccatcagg acagtcatta agccctgaaa cagaaaaacc 369061 gaatgcgctg gatgttgtcg gatatatcga aaacggaaaa ctgacgatgt cactggccta 369121 tcattctctt gaatttcatg aaaaaacagt acaaacattc agtgacagct ttaaagcgca 369181 tcttctcaga atcattgaac attgcctatc tcaagatggt acggaactga ccccgagtga 369241 tcttggtgac gacgatttga cgctggatga gctggataaa ttaatggaaa ttttctaata 369301 gaggtggcat atgagcaaaa aatcgattca aaaggtgtac gcactgacac caatgcagga 369361 gggaatgctg tatcatgcga tgcttgatcc gcattcttcc tcgtacttca cacaattaga 369421 gcttgggatt cacggcgctt ttgatcttga aatctttgag aaaagcgtca atgaactgat 369481 tcggtcatac gatattctcc gtacggtatt tgtgcatcag cagctgcaaa aaccgcgtca 369541 ggtcgtgtta gcggaacgca aaacaaaagt gcattatgag gatatcagtc atgcagacga 369601 aaaccgccag aaagagcaca ttgagcgtta caaacaagac gttcagcgcc aaggctttaa 369661 cctggcaaaa gacatattgt tcaaggtagc ggttttccgc cttgctgcag atcagctgta 369721 tcttgtctgg agcaatcatc atattatgat ggacggctgg agcatgggcg tcctcatgaa 369781 aagcctgttc caaaactatg aagcgctcag agcaggcagg acaccggcaa acggtcaggg 369841 caagccttat tccgattaca tcaagtggct tggaaaacag gacaatgaag aagcggagag 369901 ctactggagc gagcgcttgg cgggttttga acagccaagc gtgctcccgg gccgcctgcc 369961 tgtgaaaaaa gacgaatacg tcaataaaga atattcattt acatgggacg aaacactggt 370021 tgcccgtatt cagcaaaccg caaatctcca tcaagtgaca gggcctaacc tatttcaggc 370081 cgtttggggc attgttctca gcaaatacaa ctttacggat gatgtgatct tcggaacggt 370141 cgtctcggga cgaccgtctg aaatcaacgg aatcgaaacg atggcggggc tgtttatcaa 370201 caccattcca gtgcgggtga aagttgaacg agatgctgca ttcgctgata ttttcacagc 370261 tgttcagcag catgcagtag aggcagagcg ttacgattac gtgccgctct atgagattca 370321 aaaacgctca gctcttgatg gcaatctctt aaaccatctg gtcgcgtttg aaaattatcc 370381 gcttgatcaa gagcttgaaa acggcagcat ggaagaccgc ctcgggtttt cgattaaggt 370441 agaaagcgca tttgaacaaa cgagcttcga tttcaacctg attgtgtatc cgggcaaaac 370501 gtggaccgtc aaaattaaat ataacggagc cgcctttgat tccgctttta tcgaacggac 370561 agcggagcac cttacccgca tgatggaagc agctgtcgat cagccggccg cttttgtgcg 370621 tgagtacggg cttgtgggag acgaagagca gcggcaaatt gtcgaggtgt ttaacagcac 370681 gaaagccgaa ctccctgaag gaatggctgt tcaccaagtg tttgaagagc aagcgaaacg 370741 gacgccggcg agcaccgccg tcgtatatga aggaaccaag ctgacgtacc gcgagctgaa 370801 tgcagcggct aaccgtctgg cgagaaagct tgtcgaacat gggcttcaaa aaggggaaac 370861 agcagcgatt atgaacgacc gctcagtaga aaccgttgtc ggcatgctgg ctgttttaaa 370921 agcaggcgcc gcatatgtgc cgcttgatcc agcgcttcct ggggatcgtc ttcgtttcat 370981 ggcagaggac agctccgttc gaatggtttt gatcggaaat tcttatacag ggcaggcaca 371041 tcagctgcaa gtgccggttc ttacactgga cataggcttt gaagagagtg aagcggctga 371101 caatctcaac ctgccatccg ccccgtctga tttggcgtac atcatgtaca catccggttc 371161 aacgggcaaa ccgaaaggcg tcatgatcga acataaaagc attctgcgcc tcgtcaaaaa 371221 tgccgggtac gttcctgtta ctgaagaaga ccgcatggcg caaacgggag ctgtcagctt 371281 tgatgccgga acgtttgagg tattcggcgc actgctgaat ggcgcagcac tttatccggt 371341 caaaaaagag acactgcttg atgcgaaaca atttgctgca ttcctgcgtg agcaaagcat 371401 cacaactatg tggctgacat cacctttatt caaccagctt gctgcaaagg atgcgggtat 371461 gttcggcaca ctgcgccatt taatcatcgg cggagatgcc cttgtcccgc atattgtcag 371521 caaagtaaaa caggcatcgc cgtcgctttc attgtggaac ggatacggcc cgacagaaaa 371581 cacgacgttt tcaaccagtt ttctgatcga ccgcgagtat ggcggctcta tcccaatcgg 371641 gaagccgatc ggaaattcca ctgcctatat tatggatgag cagcaatgcc tgcagccaat 371701 cggcgcgcct ggtgagcttt gcgtaggcgg aatcggtgta gcgcgtgggt atgtcaatct 371761 ccctgagctg acggagaagc aatttctgga agacccgttc agaccgggtg agagaattta 371821 ccgcactggt gacttggcaa gatggctgcc ggacggcaat atcgaatttt taggcagaat 371881 cgacaaccaa gtgaaggtgc gcggcttccg aattgagctt ggcgaaattg aaacaaaact 371941 gaacatggct gagcatgtga cagaagccgc ggtgatcata cgcaagaaca aagcagacga 372001 aaatgaaatt tgcgcgtact tcacggcgga tcgtgaagtg gctgtgagtg agctgagaaa 372061 aacactgtct cagtctttgc ctgactatat ggtccctgcc cacctgattc aaatggacag 372121 cctgccgctc acgccaaacg ggaaaatcaa caaaaaggaa ctgcctgcac cgcaatcaga 372181 agccgtgcag ccggaatacg cagcaccaaa aacagagagt gaaaagaaat tagcggagat 372241 ctgggaagga atactcggcg tcaaagcagg cgttaccgat aacttcttta tgatcggcgg 372301 ccattctttg aaagcgatga tgatgacggc gaaaattcaa gagcattttc ataaggaagt 372361 tccgataaaa gtgctttttg aaaagccgac tattcaagaa ctggcactgt atttggaaga 372421 gaacgaaagc aaggaggagc agacgtttga accgatcagg caagcatctt atcagcagca 372481 ttatcctgta tccccggccc agcggagaat gtatatcctc aatcagcttg gacaagcaaa 372541 cacaagctac aacgtccccg ctgtacttct gctggaggga gaagtagata aagaccggct 372601 tgaaaacgcg attcagcaat taatcaaccg gcacgaaatc ctccgtacat cgtttgacat 372661 gatcgacgga gaggttgtgc aaaccgttca taaaaacata tcgttccagc tggaggctgc 372721 caagggacgg gaagaagacg cggaagagat aatcaaagca tttgttcagc cgtttgaatt 372781 aaaccgcgcg ccgctcgtcc gttcgaagct tgtccagctg gaagaaaaac gccacctgct 372841 gctcattgat atgcatcata ttattactga cggaagttca acaggcattc taatcggtga 372901 tcttgccaaa atatatcaag gcgcagatct ggaactgcca caaattcact ataaagatta 372961 cgcagtttgg cacaaagaac aaactaatta tcaaaaagat gaggaatact ggctcgatgt 373021 ctttaaaggc gaactgccaa tactggatct tcccgcggat ttcgagcggc cagctgaacg 373081 gagctttgcg ggagagcgcg tgatgtttgg gcttgataag caaatcacgg ctcaaatcaa 373141 atcgctcatg gcagaaacag atacgacaat gtacatgttt ttgctggcgg cgttcaatgt 373201 actcctttcc aagtacgcgt cacaggatga tatcattgtc ggctcgccga cagctggcag 373261 aacacatcct gatctgcaag gtgtgccggg tatgtttgtc aacacggtgg cactcagaac 373321 ggcaccagcg ggagataaaa ccttcgcgca attccttgaa gaggtcaaaa cagccagcct 373381 tcaagcattc gagcaccaga gctatccgct tgaggagctg attgaaaagc ttccgcttac 373441 aagggataca agcagaagtc cgctgttcag cgtgatgttc aacatgcaga atatggagat 373501 tccttcatta agattaggag atttgaagat ttcctcgtat tccatgcttc atcatgttgc 373561 gaaatttgat ctttccttgg aagcggtcga gcgtgaagag gatatcggcc taagctttga 373621 ctatgcgact gccttgttta aggacgagac gatccgccgc tggagccgcc actttgtcaa 373681 tatcatcaaa gcggccgcgg ctaatccgaa cgttcggctg tctgatgtag atctgctttc 373741 atctgcagaa acggctgctt tgctagaaga aagacatatg actcaaatta ccgaagcaac 373801 ctttgcagca ctttttgaaa aacaggccca gcaaacacct gaccattctg cggtgaaggc 373861 tggcggaaat ctgttgacct atcgcgagct tgatgaacag gcgaaccagc tggcgcatca 373921 tcttcgtgcc caaggggcag gaaatgaaga catcgtcgcg attgttatgg accggtcagc 373981 tgaagtcatg gtatccattc tcggtgtcat gaaggcgggg gcagctttcc ttccgattga 374041 tcctgataca cctgaagaac gaatccgtta ttcattagag gacagcggag caaaatttgc 374101 ggtcgtgaat gaaagaaaca tgacggctat tgggcaatat gaagggataa ttgtcagcct 374161 tgatgacggt aaatggagaa atgaaagcaa ggagcgccca tcatccattt ccgggtctcg 374221 caatcttgca tacgtcattt atacgtccgg tacgaccgga aagccaaagg gcgtgcagat 374281 tgagcatcgt aatctgacaa actatgtctc ttggtttagt gaagaggcgg gcctgacgga 374341 aaatgataag actgtattgc tttcatctta cgcatttgac cttggctata cgagcatgtt 374401 ccctgtactt ctgggcgggg gcgagctcca tatcgtccag aaggaaacct atacggcgcc 374461 ggatgaaata gcgcactata tcaaggagca tgggatcact tatatcaagc tgacaccgtc 374521 tctgttccat acaatagtga acaccgccag ttttgcaaaa gatgcgaact ttgaatcctt 374581 gcgcttgatc gtcttgggag gagaaaaaat catcccgact gatgttatcg ccttccgtaa 374641 gatgtatgga cataccgaat ttatcaatca ctacggcccg acagaagcaa cgatcggcgc 374701 catcgccggg cgggttgatc tgtatgagcc ggatgcattt gcgaaacgcc cgacaatcgg 374761 acgcccgatt gcgaatgccg gtgcgcttgt cttaaatgaa gcattgaagc ttgtgccgcc 374821 tggagcgagc ggacagctct atatcacggg acaggggctc gcgagagggt atctcaacag 374881 gcctcagctg acagccgaga gatttgtaga aaatccatat tcgccgggaa gcctcatgta 374941 caaaaccgga gatgtcgtac gaagactttc tgacggtacg cttgcattta tcggccgggc 375001 tgatgatcag gtgaaaatcc gaggctaccg cattgagccg aaagaaattg aaacggtcat 375061 gctcagcctc agcggaattc aagaagcggt tgtactagcg gtttccgagg gcggtcttca 375121 agagctttgc gcgtattata cgtcggatca agatattgaa aaagcagagc tccggtacca 375181 gctttcccta acactgccgt ctcatatgat tcctgctttc tttgtgcagg ttgacgcgat 375241 tccgctgacg gcaaacggaa aaaccgacag aaacgctctg ccgaagccta acgcggcaca 375301 atccggaggc aaggccttgg ccgcaccgga gacagcgctt gaagaaagtt tatgccgcat 375361 ttggcagaaa acgcttggca tagaagccat cggcattgat gacaattttt tcgatttagg 375421 cggccattca ttaaaaggga tgatgctgat tgccaacatt caggcggaat tggagaaaag 375481 cgtaccgctt aaagcactgt tcgagcagcc gacagttcgc cagctggcgg cttatatgga 375541 ggcgtctgct gtttcaggcg gccatcaagt actcaaaccg gctgacaagc aggatatgta 375601 tccattgtca tccgcacaga aacgaatgta cgtgctcaat cagcttgacc gccagacgat 375661 aagctacaac atgccatctg ttcttctaat ggaaggagag cttgatattt cgcgcctgcg 375721 cgactcactc aatcagcttg tgaaccgtca cgaatcattg cggacgtcat ttatggaagc 375781 taatggtgag cctgttcagc gcatcattga gaaggcggag gttgatcttc atgtgtttga 375841 agccaaagaa gacgaagcgg accaaaagat taaggaattt atccggccat tcgacttaaa 375901 cgacgcaccg ctcattcgcg cagctttgct tcgaatagaa gcgaaaaaac atttgctgct 375961 tttagatatg catcatatca tcgcagacgg cgtctcaaga ggcatctttg taaaagaatt 376021 ggcgctgctt tacaaaggag agcagcttcc ggagccgacg cttcattata aagatttcgc 376081 cgtttggcaa aatgaagctg agcaaaaaga acggatgaag gagcatgagg cgtactggat 376141 gtcagttctt tcaggcgagc tgccagagct tgatctcccg ctcgattatg cccgtccgcc 376201 tgtgcaaagc tttaaaggag atacgatccg tttccgtacg ggaagtgaga cggcaaaggc 376261 ggtagaaaaa ctgcttgccg aaaccggaac gaccttgcac atggtgctcc atgctgtttt 376321 ccacgtcttt ttaagcaaaa tttccggaca gcgggatatc gtcatcggct ccgttactgc 376381 cggccggacg aatgctgatg ttcaggacat gccgggaatg ttcgtcaata cacttgccct 376441 gagaatggaa gcgaaagaac agcaaacatt tgcggagctt ttggagctag caaagcagac 376501 gaacctgtca gcccttgagc atcaggagta tccgtttgaa gatctggtta atcagcttga 376561 tctccctcgg gatatgagcc gaaacccatt gtttaatgtg atggtgacga cagaaaaccc 376621 tgataaagaa cagcttacat tgcaaaatct gagcatttca ccttatgagg ctcatcaggg 376681 aacttctaag tttgatctga cactgggcgg atttactgat gaaaatggca ttggcttgca 376741 gctcgaatat gcgacagatc tgttcgcaaa agaaacagct gaaaaatgga gcgaatacgt 376801 tctgcggcta ctaaaggctg ttgcggataa cccgaaccag ccgctttcca gtctgttact 376861 ggtcaccgag acagaaaagc aagcgcttct tgaggcatgg aagggcaaag cgctgcctgt 376921 gccgacagac aaaacggttc atcagctatt cgaagagact gtccagcgcc acaaagaccg 376981 cccggctgtc acatacaacg gccaatcttg gacgtacggc gagctgaacg cgaaggcaaa 377041 ccgcctcgcc cggattctga tggactgcgg catcagcccg gatgaccgcg tcggcgttct 377101 cacgaagccg tcgcttgaaa tgtccgccgc ggtgctcggc gtcttgaaag ccggagcggc 377161 gtttgtgccg attgatcctg actacccgga tcagcggatt gagtatattt tacaggacag 377221 cggcgcgaag cttctcttga aacaggaagg catttcagtg ccggacagct atacgggaga 377281 tgtcattctt ctcgacggaa gccgcacgat tctaagcctg ccgcttgatg aaaacgacga 377341 gggaaatcca gaaaccgctg taaccgcgga gaacttggcg tacatgattt acacgtctgg 377401 aacgaccgga cagccgaagg gtgtcatggt cgagcaccat gcgcttgtga acctgtgctt 377461 ctggcaccac gacgcgttca gcatgacagc ggaggaccgc agtgcgaagt acgcgggctt 377521 cgggttcgac gcttccattt gggagatgtt cccgacctgg acgatcggcg ctgaacttca 377581 cgtcattgat gaagcgatcc gcctcgatat cgtccgcctg aacgattatt ttgaaacgaa 377641 cggcgtaacg atcacgttcc tgccgacaca gcttgcggaa cagttcatgg agcttgagaa 377701 cacatcactt cgcgtcctct tgaccggagg agacaagctg aagcgggcag tgaaaaagcc 377761 gtacacactc gtcaacaact acgggccgac agaaaatacg gtcgttgcca caagcgcaga 377821 aatccatccg gaggaaggct cgctttccat cggacgggcc attgccaata cgagagtata 377881 cattctcggc gagggcaatc aggtgcagcc ggaaggcgta gccggagagc tttgcgtggc 377941 ggggcgcgga ctggcacgag gctatctgaa tcgagaagac gaaaccgcga agcggtttgt 378001 cgctgatccg tttgtgccgg gtgaacgcat gtaccgcacc ggcgacttgg tgaagtgggt 378061 gaacggcggc atcgaataca tcggccggat cgaccagcag gtcaaggtcc gcggctaccg 378121 gatcgagctc tcagaaattg aagtccagct cgcccagctt tctgaggtgc aggatgcggc 378181 ggtgacagct gtcaaagata aaggcggcaa tacagcgatc gcggcgtatg tcacaccgga 378241 aacagctgac atagaagcac taaaatcaac actaaaggaa accctgccgg attacatgat 378301 cccggcgttc tgggtgacgc tgaacgagct tccggttacg gcaaacggca aagtcgaccg 378361 caaagccttg cctgagccgg acatcgaagc gggaagcgga gaatacaaag cgccgacgac 378421 cgacatggaa gagctgcttg ccggcatctg gcaggacgtg cttggaatgt ctgaagtcgg 378481 tgtcaccgac aatttcttct cgcttggcgg agattccatc aaaggaattc aaatggcgag 378541 ccgcttgaat cagcacggct ggaagctgga aatgaaagat ctcttccagc atccgacgat 378601 cgaagagctc acccagtacg tagagcgtgc cgaaggcaaa caggcagacc aaggcccggt 378661 ggagggcgaa gtcatcctga cgccgatcca gcgctggttc tttgaaaaga acttcacgaa 378721 caagcaccac tggaaccaat cggtgatgct tcacgccaaa aagggctttg atcctgaacg 378781 ggtggagaaa acattgcagg cgctgatcga gcatcatgac gcgctccgca tggtctaccg 378841 cgaggaaaac ggggacatcg ttcaggtgta taaaccgatc ggtgagagca aggtcagctt 378901 cgaaatcgtg gatctgtacg gctccgatga agagatgctg agaagccaga ttaagcttct 378961 cgcgaacaag ctgcaaagca gtctcgatct gcgaaacggg ccgcttttaa aggcggagca 379021 atatcgcaca gaagctgggg atcacctgct cattgctgta caccatctcg tggtcgacgg 379081 tgtgtcatgg cggattttgc ttgaagactt tgcttcaggc tacatgcagg ctgagaaaga 379141 agagagcctt gtcttcccgc aaaaaacaaa ctccttcaag gattgggcgg aagaactggc 379201 ggcattcagc caatcagcgc atcttttaca gcaggctgaa tactggtcgc aaattgccgc 379261 tgaacaggtt tctcctttac ctaaggattg tgaaacagag cagcggatcg tcaaggatac 379321 atcatctgtc ctatgtgaat taacggcaga agacactaag catcttttaa cagatgttca 379381 tcagccatat ggaactgaaa tcaacgatat tcttctcagc gcgctcggtt tgacaatgaa 379441 agaatggaca aagggggcca aaattggcat taaccttgag ggacacggcc gggaggacat 379501 tatcccgaat gtgaatatct ccagaacggt cggctggttt acggcacaat accctgttgt 379561 gctcgacata tctgacgcag atgcctcagc tgtgatcaaa acagtcaaag aaaacctgcg 379621 ccgcattccg gacaaaggtg ttggctacgg cattcttcgt tatttcacag aaacagcgga 379681 aacaaagggc ttcacaccgg agatcagctt caactatttg ggccaattcg acagtgaagt 379741 caaaaccgat ttctttgaac cgtccgcttt cgatatgggg cgccaagtaa gcggagaatc 379801 agaggcgctg tacgcattaa gcttcagcgg catgatcaga aacggccggt ttgtgctttc 379861 ctgctcctac aatgagaagg agtttgaaag agctacagtc gaggagcaaa tggaacggtt 379921 taaagaaaac ctcctgatgc taatccgcca ttgcacggaa aaagaagaca aggaattcac 379981 accaagcgac ttcagcgccg aagaccttga aatggacgag atgggagata tctttgacat 380041 gcttgaggag aatttaaaat aaaacgcaag ggaattacag aaggcgggag cgaaacatat 380101 gagtcaattt agcaaggatc aggttcaaga tatgtattac ctatcgccga tgcaggaagg 380161 gatgcttttt catgccatcc tgaatcccgg ccaaagcttt taccttgaac aaatcacgat 380221 gaaagtaaaa ggcagcttga atatcaaatg tcttgaagaa agcatgaatg tgatcatgga 380281 ccggtacgat gtatttcgta ccgtgttcat tcacgaaaaa gtaaaaaggc ctgtccaagt 380341 cgtattgaaa aaacggcagt tccatataga agaaatcgat ctgacacact taacgggcag 380401 cgagcaaaca gccaaaatca atgagtacaa agaacaggat aagatcaggg gttttgattt 380461 gacgcgggat attccgatgc gggcagccat tttcaagaaa gctgaagaaa gctttgaatg 380521 ggtgtggagc taccaccaca ttattttgga cggatggtgc ttcggcatcg tcgtacagga 380581 tctatttaag gtatacaatg ctctgcgcga acaaaagccg tacagcctgc cgcccgtcaa 380641 accgtataaa gactacatca agtggcttga aaagcaggat aaacaagcat cactgcgtta 380701 ctggcgcgaa tatttagagg gctttgaagg acaaacgacg tttgcggagc aaagaaagaa 380761 acaaaaggac ggctatgagc cgaaagagct gctcttttca ctgtcggagg cggaaacaaa 380821 ggcctttacc gagcttgcaa aatcgcagca taccactttg agtacggcgc tgcaggcagt 380881 ctggagcgta ttgatcagcc gctatcagca gtctggcgat ttggccttcg gtacagttgt 380941 ttcagggcgt cccgcggaaa tcaaaggcgt tgaacatatg gtcgggctgt ttatcaacgt 381001 tgtcccgaga cgtgtgaagc tgtctgaggg tatcacattt aacggcttgc tcaagcggct 381061 gcaggagcaa tcgctgcagt ccgagccgca tcaatatgtg ccgctttatg acatccaaag 381121 ccaggccgat cagccgaaac tgattgacca catcattgtt tttgagaact atccgcttca 381181 ggatgcgaaa aatgaagaaa gcagtgaaaa cggctttgat atggtggatg ttcatgtttt 381241 tgagaagtcg aattatgatc tcaacctgat ggcttccccg ggagatgaga tgctgattaa 381301 gcttgcctat aatgagaatg tgtttgatga ggcgtttatc ctgcgcttga aatctcagct 381361 tcttacagca attcagcagc tcatccagaa tcctgatcag cctgtcagca cgatcaacct 381421 cgttgacgac agggagagag aatttttgct aaccggctta aacccgccgg ctcaagctca 381481 tgaaacaaag cctctgacgt attggttcaa ggaagcagtg aacgccaatc cggatgcacc 381541 ggcgcttacg tattccggcc agaccctgtc ttatcgcgaa ttagatgagg aagcgaaccg 381601 cattgcacgc cggctgcaaa aacacggtgc gggcaaaggc tctgttgtag cgctgtacac 381661 gaagcgctca cttgaactgg tgatcggcat tctcggtgta ttaaaggcgg gagcagccta 381721 tctgccggtt gatccgaagc tgccagagga ccgaatctcg tatatgctgg ctgacagtgc 381781 ggcagcctgt cttctgacgc atcaggagat gaaagaacaa gcggctgagc tgccgtatac 381841 aggcacaacg ctcttcattg atgatcaaac acggtttgaa gaacaggcaa gcgatcctgc 381901 aaccgcgatt gatcctaatg atccggcata tatcatgtac acgtccggca caaccggaaa 381961 gccaaagggc aatatcacca ctcatgccaa tattcaagga ttggtcaagc atgtagacta 382021 catggcattt tctgatcagg atacgttctt gtctgtttcg aattacgcct ttgatgcatt 382081 tacctttgat ttctatgctt ctatgctgaa tgcggcacgg ctcattatcg cagatgaaca 382141 tacgctgctt gatacagaac ggctcacaga tctgatcctg caagagaatg tcaatgtcat 382201 gtttgcgaca accgcactat ttaatcttct cacagatgcg ggagaggatt ggatgaaggg 382261 gcttcgctgt atattattcg gcggagagcg cgcgtcagtg cctcatgtca gaaaagcgct 382321 gcggatcatg gggccgggca agctgattaa ctgctacggg ccgactgagg gaacagtgtt 382381 tgcgacagct cacgtcgtgc atgatctgcc ggattccatc tcctcattgc cgatcggaaa 382441 gccgatcagc aatgccagtg tttatattct gaatgagcaa agccagctcc agccattcgg 382501 ggcggtcggt gaactgtgca tcagcggaat gggcgtgtca aaagggtatg taaatcgtgc 382561 tgacctcacg aaggaaaagt ttatcgagaa cccgttcaag ccgggagaaa cgctttaccg 382621 tacaggggat ttagcgcgct ggctgccgga tggaacgatt gaatacgccg gccgtattga 382681 cgaccaggtc aaaatacgcg gacaccggat tgagcttgaa gaaatcgaaa agcagctgca 382741 ggaataccca ggtgtgaaag atgcggtcgt tgtggcggac cgccatgagt ctggcgatgc 382801 atcaatcaat gcctaccttg tgaaccgaac gcagctttca gctgaagacg tgaaggcgca 382861 cctgaaaaaa cagcttcctg cttacatggt gccgcaaacc tttaccttct tggatgagct 382921 tcctttaacg acgaacggga aagtcaataa acggctgctc ccaaaacctg atcaggatca 382981 gctggcggaa gaatggattg gaccgcggaa cgagatggaa gaaacaatcg cacaaatatg 383041 gtctgaggtt ctcggcagaa agcaaattgg cattcatgac gatttctttg cgctcggagg 383101 gcattccttg aaggccatga ccgccgcgtc ccgcatcaag aaagagctcg ggattgatct 383161 tccagtgaag cttttgtttg aagcgccgac gatcgccggc atttcagcgt atttgaaaaa 383221 cgggggctct gatggcttgc aggatgtaac gataatgaat caggatcagg agcagatcat 383281 tttcgcattt ccgccggttc tgggctatgg ccttatgtac caaaatctgt ccagccgctt 383341 gccgtcatac aagctatgcg cctttgattt tattgaggag gaagaccggc ttgaccgcta 383401 tgcggatttg atccagaagc tgcagccgga agggccttta acattgtttg gatattcagc 383461 gggatgcagc ctggcgtttg aagctgcgaa aaagcttgag gaacaaggcc gtattgttca 383521 gcggatcatc atggtggatt cctataaaaa acaaggtgtc agtgatctgg acggacgcac 383581 ggttgaaagt gatgtcgaag cgttgatgaa tgtcaatcgg gacaatgaag cgctcaacag 383641 cgaagccgtc aaacacggcc tcaagcaaaa aacacatgcc ttttactcat actacgtcaa 383701 cctgatcagc acaggccagg tgaaagcaga tattgatctg ttgacttccg gcgctgattt 383761 tgacatgccg gaatggcttg catcatggga agaagctaca acaggtgttt accgtgtgaa 383821 aagaggcttc ggaacacacg cagaaatgct gcagggcgaa acgctagata ggaatgcgga 383881 gattttgctc gaatttctta atacacaaac cgtaacggtt tcataaatga agtgatgaaa 383941 ggaggagaca gccaatgagc caactcttca aatcatttga tgcgtcggaa aaaacacagc 384001 tcatctgttt tccgtttgcc ggcggctatt cggcgtcgtt tcgccctctc catgcttttt 384061 tgcaggggga gtgcgagatg ctcgctgccg agccgccggg acacggcacg aatcaaacgt 384121 cagccattga ggatctcgaa gagctgacgg atttgtacaa gcaagaactg aaccttcgcc 384181 ctgatcggcc gtttgtgctg ttcggacaca gtatgggcgg aatgatcacc ttcaggctgg 384241 cgcaaaagct tgagcgtgaa ggcatctttc cgcaggcggt tatcatttct gcaatccagc 384301 cgcctcatat tcagcggaag aaagtgtccc acctgcctga tgatcagttt ctcgatcata 384361 ttatccaatt aggcggaatg cccgcagagc ttgttgaaaa taaggaggtc atgtcctttt 384421 tcctgccttc tttccgatca gattaccggg ctcttgaaca atttgagctt tacgatctgg 384481 cccagatcca gtcgcctgtt catgtcttta acgggcttga tgataaaaaa tgcatacgag 384541 atgcggaagg gtggaagaag tgggcaaaag acatcacatt ccatcaattt gacggcgggc 384601 acatgttcct gctgtcacaa acggaagaag tcgcagaacg gatttttgcg atcttgaatc 384661 agcatccgat cattcaaccg tgatcaaaag cggacagctt cggctgttcc gctttttttg 384721 tgttgaatgc caatttctgc atggtataat agtcgaaata ctcaaataaa ggcaggtcga 384781 aacatgcgca cgtctcccag gatgaaatgg tttgtattgc tgtttacgtt tgttttcgcc 384841 atcggaatga actcattcag aaattccttt caatttttta tgctgccaat ggcagacgcc 384901 ttccatgccg acaggtcgct gatttcggtt tctgtcagca tttttatgat cacaaccggc 384961 atcgtccagt tttttgtcgg tttttttatc gaccgtttca gtgtcagaaa aattatggcg 385021 ctgggagctg tttgcatcag cgcaagcttt ttggtgcttc cttattcacc gaatgttcat 385081 gtgttttccg ccatttacgg tgtgcttggc ggaatcgggt attcctgcgc ggtcggcgtg 385141 acgacccagt atttcatcag ctgttggttt gacacacaca aaggtctggc gcttgctatt 385201 ttgaccaatg ccaactctgc gggcctgctg cttctctcgc ccatttgggc tgcggctccg 385261 tatcatgccg gctggcagag cacctatacc attttgggaa tcgtcatggc ggctgttctg 385321 ctgccgctcc tcgtctttgg gatgaagcac ccgccacatg cgcaagcgga aactgtgaaa 385381 aaatcttatg attggcgagg gttttggaac gtgatgaagc aatcccgcct cattcatatc 385441 ctgtacttcg gcgtgtttac ttgcggattt acaatgggaa ttattgatgc tcacctcgtc 385501 ccgatactga aggatgcgca tgtctctcat gtcaacggaa tgatggccgc gttcggggca 385561 tttatcatca ttggcggatt attggcgggc tggctgtcag atctcctcgg cagcagaagc 385621 gtcatgctat ccatcttatt tttcattcgg ctgctcagcc tcatttgcct gctcattccc 385681 attctcggaa ttcatcacag cgacctttgg tacttcgggt ttatcctgtt attcgggctc 385741 agttacacag gcgtgatccc gctgaccgcg gcgtcaattt cggaaagcta tcaaacagga 385801 ttgatcggat cgctgttagg catcaatttc tttatccatc aggttgccgg agctctcagc 385861 gtgtatgcgg gcggtttgtt ttttgacatg actcatggtt atttactgat tgtcgctgtg 385921 tgcatcgtgt ttgtgggttt atcggctgta atagagctgg tgccgttttt agataaacag 385981 aaggcaaaag aaacccacca ttcaatataa aaggatcagc actgtcaatg ctgatccttt 386041 ttaaatttga gtttttttgt ttcggtattt ttaaggataa tctccttgaa tctgttcatc 386101 tcctcttcgg agtgaaaaaa atgtttgggg atcgcaatat attggccact tgatgtattg 386161 accctgaaga tatttttata ttcgaaaaca gctgtaattt catcccaatt gaaaatgagg 386221 tcatattttt tagaacatat acgaattcct tcttggttca gagtatatgt tcttttggat 386281 ttcatccgtt cgttcttctt gtatgctctg gaaaacttca catatagaag aaggaggagc 386341 agcagtgtaa acagaacgga catcacgata atcaacatac tgttcataaa caagttaagc 386401 gcgtcacttc cataaacgat acggggccat ccgttaatga agttaactgc agcaaatatg 386461 gcgcaaaaca atagaaagta aaagcatgat atttttgcga tttgataaaa aaagatttct 386521 cttacatcct taaaagtgat ttctcctgga agattgatac tttcactagc atattgaatc 386581 atacggtaaa cctacacctc taaccatgtt tttcctttta gtctagcata atttctcatt 386641 tttttgcagg cataccaggg cgctttgttt ttttctccag attgatattg ctccccacca 386701 cgccaatcat aatacaaaca gccccggcaa gatgatacca ggccaggctt tcgttgagaa 386761 tcacaaatcc tgcaatcatc gtcacaatgg tagatacatg attaaaagcg ctcattttaa 386821 acgcctcaat tcgcgacagc gtatagttag acagaaatga agtgacaagt gaagacagca 386881 cgcccaaata cacaatggcg agaacgaagc cgggctcccg gaacggcaga aaataagtgc 386941 cgactgttcc cgccgctccg tgacgcacaa gggcgatggc gttgaagacg acaaagccga 387001 tggctgacat gatgtaggtg agctcggtca gcttgaaccg ctgcgtcatt tttctggcag 387061 cagtattgta catcgctgaa gacaaagcgg acaataggat cagcaaagac ccttttaagc 387121 tggctgattc cacgtcaacg cctttcatca caaaaataaa catgacgccg gcaacggata 387181 aaaccgtgaa ccccttttgc gtccacgttg ggcgttcctt taaaacataa gcggcaaaga 387241 ccatcgtgaa aatcggaatg gctgcctgaa taattcccgc ttcagaggag gacgagtaca 387301 caaggccgaa tgcctgaaag ctgaaaaata acgcgggata cagcagggcg agcggcaaaa 387361 tgtcaatgac gtcctttacg cggattgata gctttaccca gccgaataag atcggtacag 387421 tggccgcagc aaacgcaatg gtgaaccgat gcgccaaaat atcaaacggc tctgctgttt 387481 gcagtgcgat ttttacgaat agaaaggata aaccgataat gaacgaatat aaaatagccg 387541 ctatataagc gggggtttgc tgatgtttaa ccataatggg aagggctcct ttacctgaat 387601 tgcagcgccg gtcgctccct ttattgtatg gccgcggtca gaacggtaca atgagaaaaa 387661 caatgaactg taccggtaca aaacaggggg agaaggcatg gagaaatata tgagtctatt 387721 aacgaggata gaggagatga tgcaaagcac ctcatatcaa gaaggagaca ggcttccatc 387781 tatccgtcag ctgtccgccc gctaccaagt cagcaaaagc acagtgatcc gcgcgctgca 387841 ggagctggaa aagcgccacc ttatctattc tgttccgaaa agcggctatt atattgtgaa 387901 aaagtcaggg aaatcaaaaa gcgggcagcc tggccccatc gactttgcca catctgcgcc 387961 ggatcccgat gtgtttccgt atcttgattt tcagcactgc atcaacaaag cgattgatac 388021 atacaaaaac gatttgttta tttatgggac gccaaagggg cttccatcac tcatccgcgt 388081 actccgaaag ctcttggcca ctcaacaggt atttgcggat gaacggcata ttttcattac 388141 atcaggtgtc cagcaggcgt tatccttgct ttgtgccatg ccgttcccaa atgggaaaga 388201 gaagatcgcc attgaacagc cgggctacca tttgatggtc gaacagcttg agacacttgg 388261 gattcccgcc atcggggtga aacgaacgga agaagggctt gatatagcca aggttgagcg 388321 gttatttcaa acagaatcga ttaaattttt ttatacgatg ccgcgcttcc ataacccgct 388381 tgggtgctca ttgtcagagc gtgataaaca ggagcttgtg agactggcag aagcgtatga 388441 tgtctatctc gttgaggatg attacctcgg tgatctggag gaaaataaaa aggcagatcc 388501 gctgtacgca tatgatctgt cctcacatgt catctatttg aaaagcttct cgaaaatgat 388561 gttccccggc ctccgcgtgg gggcggctgt tttgcccgaa gcgctgactg acacgttcta 388621 tgcgtacaaa aagctgaacg acatcgactg ttcgatgatt tctcaagcgg cattggagat 388681 ttacctgaaa agcggtatgt acggcaggca taaggagaaa atcagagatt cttataaaga 388741 gcggtcgctg aggctacatc aagccattcg aactcacagg cagctgggaa gcggacgctt 388801 tacgttctcc agcgggcagg caccctgtat gcacacccat ctggtgcttc ctcaggatct 388861 gcccgcctca agagtgattc atagactgga aaaacaaggg gttctccttg aggcgataga 388921 ccgtcattat ttatcagatt atccgaaaga aaatctatta aaaatcaata tttccaatgt 388981 gaaaacggaa gatattgagc gcggtgtcaa gctgttgatg agccatttat aaaagctctt 389041 cgtacgagac cattgtgata tcctcgggga aatcagggtg tacggcgcat acagccattt 389101 tgtagccggg atcgacctca tacgttttga tatagcatgg ggaatggctg tccggaagct 389161 caatggatac ttgtccgtcc tggtgcaggc gcactgaaaa ggaatcaagc ggaagcgata 389221 agcctttgcc ttccttgttt gataaagctt tctttcattg accatagatg ataaaaatag 389281 tctgtctgct cgtccttgtc ttttgctaaa aggtcgctgt actctgtttt tgaaaagaag 389341 cgcttggcga tctcaaggct gatcggtttc gttttttcga tatctatgcc gatcggctgt 389401 gaatcaaacg cgcaaatgac ccagcgtccg gagtgagaaa tgttgaaatg agcgtcggga 389461 agatcaggga tgcacggctt cccgtattcc tgcgtgctaa agcggatatc ggatttgtcc 389521 aactgatact gcctgcttat gactgagcga acgagcacat ctcccagcag ggtgcggtga 389581 gcatcttctt tatgataaaa tctccggcat ttctcccgtt tttcaggtga tatgaaagac 389641 atgaaccgtt cattttcttc ctgtgaaagc gggcggtcca tataaattcc gtaaatcttc 389701 attctagatc ctccgtctgc aaaagattgt caaaaccatc ctatcatact tccacaagac 389761 tcatatagag gagaaaataa aaaaacaaag ccaaggcggc tttgttttag tgtacaggcg 389821 gagatgcttt cactgcggct gtccgccttg ccacagcata attcagcaac tggattgact 389881 ggggcaatga aaaacgcaaa ataagtccgg tgaggatggc ggtcaaaatg gtgccaaaac 389941 cgatcggtcc gcccatgccc catgccgcaa acaaaatggt taattccatg ccgttccgca 390001 cccattgcac attccagccg gttttttctg taatcagcat catcagtgaa tcacgcggcc 390061 ccgcgccaag gcctgctgat acataaacac cgacgccgta accaatcagc accacgccta 390121 gagagaagac gatgatcgag cctgtgtagg tcgagagggc aggcagaatg aaattgaaaa 390181 aatctataaa tacaccaatg agcaccatat tcaggagggc accaattttc ggccaagctc 390241 tcgtaaacaa tgacgtgaat ccgacgatga gcgctccaat aatgatggac cactggccga 390301 cggtaagccc gaagtgctga aacaggctgt aatgaaatgc atcccacgga ctaatgccga 390361 gtgcttttcc ttctatcgtc agggatacac caaaagccaa aatgatcaaa ccggcaaaat 390421 aaaatgtcca gcgcagaaca agttcttgct tcacgtgagg tcccttcttt cgtaaaaatc 390481 agtcgattgt cattgtagca catctgacag aagggcggaa taggcgaaag gggctcaaca 390541 aaaaaacagg gccgccggag gcgccctgtt tcagcgtgtt ggcaaaccct tgcattcgtt 390601 gtcaggcctg tgcttcggtg ctcacgaatt taacattagc tgtgctccaa tgctcgccct 390661 tcctagactt caaaggtttt caatcacgct gaaaatcaca aaatcctaaa acgaatatcg 390721 ttttaggatt ttgtcaataa tctgaaacag ggcgctgacg ctctgttttt cttattacag 390781 cgggttcaaa atccggttta agaaccgctg tgtccgttct tcttttggtg cggagaaaat 390841 ttgctccggc ggtccctgct ccacgataac gccgccgtcg atgaagatga cttcatccgc 390901 aacctcctgc gcgaacttga tttcgtgggt cacgacgacc atggtccagc cttcattggc 390961 caagtccttg ataaccttca gcacctctcc gacaagctcg ggatcaagcg ctgaggtcgg 391021 ttcgtcaaac agcatgagct caggctgtat cgccagtgcg cgggcgatgc cgacgcgctg 391081 ctgctggccg ccggaaagct ggaacggata taaatccatt ttgtccttca atccgacttt 391141 atcaagaagc tgaatcgctt cttttctgac ttcctctttg ttccgttttt gcacctgaac 391201 agggccctcc atcacgtttt cgagggctgt gcggtgcggg aacaggtgat acgcctgaaa 391261 caccattccg gattttcggc gaagctttag gatatccgcc tgtttcacct ttttggagaa 391321 atcgatggag aaatcatcaa atgcaagctc tccgcgattc gggatctcca gagcgttcag 391381 gcagcggagc agcgtcgttt tccctgaacc tgaaggccca agtatggcga tgacttttcc 391441 tttttcaatc ttcatatcta tcttttttaa aatttcattt tcaccgaatg atttgtttaa 391501 tcctttaacg gtaagcatac tcggaacctc cttatttggc cacgtagcgg tcaagacgcc 391561 gttcgatgac atgctggacg agtgagagca ggaagcagat aatccaataa ataaaggctg 391621 cttcaatata gatcactaaa atttgatcaa gattccgcgc gccgatttcc tgggcttttc 391681 tgaacagctc agcgaccaga atttgagagg cgagggatgt atctttaatc aggctgataa 391741 aggtattgga taatggcggg atcgacacac gaaacgcctg cggcaaaatg acgcggaaca 391801 gcgttttttg atgtgtcatg ccaattgtgt agccggcttc ccattgccct ttcggcacgg 391861 ataaaataga tgcccgaatg atttcagatg cataggcgcc gacgtttaat gaaaaggcga 391921 taactgcgct tggaaatgga tctaatgtga cgttaaaggc cgggaacaga tagaaaatga 391981 tgaacaattg aacgagaaga ggagtgccgc gtattgcgga tacgtatacg ctgaacaccc 392041 atctcaaagg tctcactttc gacattctgg caagcgccgt aatcagcgcc aggatcattc 392101 cgaatataaa ggaaagaatc gtaaggggaa tcgtatagta gattccccct gaaagtatcg 392161 gccagaatga ctgctgcacc agatcccacg ggatcgccgt gccaagcgtc aatgccggca 392221 gattatttag aaacatcttc gccgaaccat tttttagaaa ttttagaaag agtcccgtcc 392281 tctttcattt cttttaatgc tttgttgact tgatcaacaa cctcgccgct tcctttacgg 392341 aacgtgaaat atgttgactg aggctcacct gtttcaaacg cgattttcac gtttttattg 392401 ccagatgttt ttaagtagtt caatacggca agcttatcgt tgtatgtcat atcgacgcgg 392461 ccttgctgga tcatttgaag ggcctgcgcc atgccttcaa cgccttctac tttagcgccg 392521 gcatttgtag ctaatttgtt gtagttgctt gtcagtgatt gagctgacgt ttttcctttt 392581 acatctgctt cagacttaat atcgttgttg tcttttttcg ttacgacaac ggctcttgat 392641 gttgtgtatt tatctgagaa atcatatttg tcttcacgat ctgtttttcc gacttggttg 392701 gcaacaacgt caaaccgttt ggaattcagg ccggcaaaca tactgtccca ttgtgtttcc 392761 ttaaagtcga ctttaagccc gaggcgtttt gcgacttctg tgataacttc gacatcatag 392821 ccagtcagtt tatcagtgtc tttgtcgtgg taagtgaacg gctcatatgt tccttccgtt 392881 ccgactgtga gcacaccttt tttcttaatt gaagcccaaa gatcgccatc tttggcatta 392941 tcttttgact gattgtcatt tcctgctccg caagctgcaa gagctgcaat acttacgacc 393001 atgaataaag ccaataatgc ttttttcatc ttattcccca cttttctggt tgattttatt 393061 gaaataaaaa attagcttac aaatctaaag gataactttt ttttagtatg agtcaagtat 393121 ttggttttca taagacaaaa tcttttaaaa taaatccaaa aattgctgtg ccggtttagg 393181 caaataactg tccgttctcc acatgacagc cggtgtcata atgaagggat tattttcgat 393241 atggacggtg tgaacgtgat ttctcatatg aacgggaatc attgtgacag gcaaaataga 393301 cgcgccgaat ccggatgaca cgaggctgag caaagttgca gagtcgtggc attcacaaac 393361 aatgcgcggc tccaggttca aacgatgaaa ttcattcatg acctgattat agacgccttt 393421 tccgttgaca ggccgcagca ggatcagcgg aaatgaagga atgtccacca tcttaatggt 393481 gtctccgcac ggatatccgg cttcatctga aagcacgagc acacatggaa tgtcatcaag 393541 ctgcttgaat tgtactgtgt cacttttgat cagtgttgtc gtgaccgccg catcgatttg 393601 ccggctttcc agcagttcca acagtgtcgc gggttcattt tcccaaatat taaaggtgag 393661 atgggggtat ctctctttga tctgtgttac tttttcaagc atcagagccg cgcaataaat 393721 cgttgatccc acggcaagtg taccggctac ttcctccttc agctcctgta cctcaatgac 393781 tgcatcttca aacctatgca gaatctcttt tgctcttttt agaaaaacag ctccttcata 393841 tgtaagagtc atttgttttt tcttgttacg gtcaaacaga acaacaccaa gttcgtcctc 393901 cagctgtttg agctgcctgc ttaaaggcgg ctgcgccatg tgaagctttt tggctgcgga 393961 cgtaattttc tgttcttggg caatggtaat gaagtatcga agctggcgaa tatccaaaag 394021 aaagcgcctc cttatcatac cttttaggta ttaattatag atttaataga tatttttcat 394081 atggatatat caggagtatg attgaaatga aagcagaatt caagcgtaaa ggagggggca 394141 aagtgaaact cgttgtcgga atgacagggg caacaggggc cattttcggg gtcaggctgc 394201 tgcagtggct gaaggccgcc ggagtggaaa cccatctcgt tgtgtctcct tgggcaaacg 394261 tcacgatcaa acacgaaaca ggctatacgt tacaagaagt agaacaactg gccacataca 394321 cttactcaca taaggatcag gcggcagcca tttcaagcgg gtcgtttgat accgatggaa 394381 tgattgttgc gccgtgcagc atgaaatctc tcgcaagcat tcgcacagga atggcggata 394441 atctgctgac acgtgcggcg gatgtcatgc tcaaggagag aaaaaaactc gtcctcttaa 394501 cgagagagac gcctttgaac caaattcatc tcgaaaatat gctagcgctt acgaaaatgg 394561 gcaccatcat tcttcctccg atgccggcat tttataatcg gccgagaagc ttagaggaaa 394621 tggttgacca tattgttttt agaacgttgg accaattcgg cattcggctt cctgaagcga 394681 agcgctggaa tgggattgaa aaacaaaaag gaggagcttg atcatggctt atcaagattt 394741 cagagaattt ctcgctgccc ttgaaaaaga aggacagctg cttacagtga atgaagaggt 394801 aaagccggaa ccggatttag gggcctccgc acgggcagcc agcaatcttg gcgataaaag 394861 ccctgcgctc ttatttaaca acatttacgg ctatcataac gcgcgaattg cgatgaatgt 394921 catcggctct tggccaaacc atgccatgat gctgggcatg ccgaaagaca caccggtaaa 394981 agaacagttt tttgaattcg caaagcgtta tgaccagttt ccgatgccgg tcaaacgtga 395041 ggaaacagcg ccatttcatg aaaatgaaat cacagaagat atcaatttgt tcgatatact 395101 gcctcttttc agaattaacc agggtgatgg aggctactat ttagacaaag catgtgtcat 395161 ttcccgtgat cttgaggacc ctgacaactt cggcaaacaa aatgtcggca tttacagaat 395221 gcaagtcaaa ggaaaagacc gccttggcat tcagcctgtc ccgcagcacg atattgcaat 395281 ccatctgcgc caagctgaag aacgcggcat caaccttccg gtcactattg cgctcggctg 395341 tgagccggtc attacaacgg cggcatcgac tccgcttctc tatgatcaat cagaatacga 395401 aatggcaggt gcgattcaag gcgaaccata tcgcatcgtc aaatcaaagc tgtctgatct 395461 tgatgttccg tggggcgctg aagtggtgct tgaaggtgag attattgccg gagagcgcga 395521 atatgaaggg ccgttcggtg aattcacagg ccattattcc ggcggacgca gcatgccgat 395581 tatcaaaatt aaacgcgtct atcacagaaa caatccgatc tttgaacatt tatacttagg 395641 catgccttgg acagaatgcg attacatgat cggcattaac acatgcgtgc cgctttatca 395701 gcagttaaaa gaagcgtatc cgaacgaaat tgtggcagtg aacgccatgt acacacacgg 395761 tttaatcgcg attgtttcca caaaaacccg ctatggcgga tttgcgaaag cggtcggcat 395821 gcgcgcactc acaacgccgc acggactcgg ctactgcaaa atggtcatag tcgttgatga 395881 ggatgtcgat ccattcaacc ttccgcaggt catgtgggcg ctttcgacca aaatgcatcc 395941 gaaacatgat gcggtcatca ttccggactt atctgtcctg ccgcttgatc cgggatccaa 396001 tccatcagga atcactcaca aaatgattct cgacgccact acaccggttg cgccggaaac 396061 aagaggccat tattcacagc cgcttgattc tccgctaaca acgaaagaat gggaacaaaa 396121 actaatggac ttaatgaata aataaggaaa ggatgttcga aatgcataca tgtcctcgat 396181 gcgactcaaa aaagggagaa gtcatgagca aatcgcctgt agaaggcgca tgggaagttt 396241 atcagtgcca aacatgcttt tttacatgga gatcctgtga accggaaagc attacaaatc 396301 ccgaaaaata caatccagcg tttaaaattg atccaaagga aacagaaaca gcaattgaag 396361 ttccggcggt gccggaacga aaggcttgat ccgcgtgaac tgtatgtcag accgtctctt 396421 tgagctgctt gacgggagct gcctgaatga gaagcagcat gaggccttcg ttctgcaaac 396481 agtatcagag gatggctggc cgcatgccgc tatgatcagt gcaggtgaaa tcatcgcgct 396541 gagccgaact gatatccgaa tcgctctgtg gaaaaacaca atgacttcgg ccaacatcct 396601 tcgcacagga aaagcacagt tcacggcgtg gtggaaggga gcggcctatt atgtaaagct 396661 tgaatgcgcg cctttaccgc ctttgaaaga tgccgaatat gaaagagacc gtttttcctg 396721 ccgcatcgtt tcagtgaaag aggacgttgc gaaatacgct gatttgactt caggtgtccg 396781 tatacagctt cacagccctg aagaggtgct gagcagatgg aaaaagaccc tggaagattt 396841 aaaacggtaa tatcgatagc ctgacgccat gcgtcaggct ttttttatat aatgaaaaca 396901 aaagggggcg tgagaaatgg aacgtgcggg gatctgtcac tcggacggct ttgatttagc 396961 ttatcgaatt gagggcgagg gcgcacccat ccttgtgatc gggagtgcgg tttactatcc 397021 gcgccttttt tcctcagata tcaaacagaa atatcaatgg gtctttgtcg accatagggg 397081 atttgctaag cctaagcggg agcttcgtgc ggaggattcg aggcttgatg ctgtcttggc 397141 tgatatcgaa aggatgagaa catttcttca gcttgaggat gttactatcc tgggacattc 397201 cgggcacgct tttatggctt tagagtatgc caggacatat cccaaacaag ttcggaaggt 397261 ggcgctcttt aatactgcgc ctgataacag tgaagaaaga cagcgaaaaa gcgaatcatt 397321 tttcatggaa acagccagtc ttgagagaaa gaaacgcttt gaaaaagaca tcgagaattt 397381 gccgcaggac atcgacaaag atcctgaaag gcgctttgtg cacatgtgta ttcgcgctga 397441 agcgaaaagc ttttatcaag agcggccgca tgctgctgcc ttatgggacg gtgtattcac 397501 gaatatgccg atcattgatg aattatgggg caatacattt gcccggattg atcttcttca 397561 gcggttagct gatgttcgta tgccggtgta tatcggatta gggagatatg attatttggt 397621 tgcgcccgtt tcgctatggg atgctgttga cggtttatat ccccatgttg ataaggttat 397681 ttttgaaaag agcggccatc agccgatgct ggaagaaccg gaagcctttg atcaaagctt 397741 caggaaatgg cttgatcaat aaaaaacagc ccgcagatca acatccgcgg gctgtttctg 397801 attataagac ccctttcatc gcgcgtttga tcaccggcga gagcagcagg agaatgccgc 397861 caagaacgat agaaatcaaa ccgatggtgc cgaagtacat tgtttcagga attttatcaa 397921 acaatccggc tacttgggca ttgatcgctt gggctgctgc gttcgtcaga aaccacatac 397981 tcattgtctg tgcagagaag gcagctggtg ccagtttcgt tgtcacggat aaaccgactg 398041 gagacaggca cagctctcca agcacgacaa gcaggaagct gagaacgagc caaagcgggc 398101 ttacgagtgc ttcttttcct tgcatagcag ggaataccat aatgataaat gacaatccgg 398161 ctaaaataat tccgattgag aatttaactg gtgtagacgg ctgacgtttg ccaagcttca 398221 tccagagcca tgcgaatatt ggcgcaaaaa tgacaacaaa caatggattt aatgattgga 398281 accatgatga ctgaagttcg aatccgccca atgaaagtct tatgcgttca tcagcgtata 398341 ccgcaagaat ggtcgctccc tgttcctgaa tggcccagaa catgacagca ccgataaaca 398401 aaggaacgta agcggcaaga cgggattttt ctgttttgtc cgcttttttg cttgtaaaca 398461 tgatgatgaa ataaatcaca ggaatcaaaa taccgagaat acttacaagg tcaatgaaac 398521 gtttgatcgt cagcacgcct gtttgtacag agataatcac tgcgatcgcc acaatgataa 398581 caccgattcc ggtgccaatt gcagattttt tagacagcgg attcggcaca ttggaacctg 398641 caagcccgag gtttttcttt cttgtcaaag caaatacgat aagtccgaga agcattccga 398701 ccgcggcagc tccgaatccg agatgatagt tgtacttctg tccgagtgtt ccgacaatta 398761 acggcgcgag taaaccaccg aggttaatcc ccatgtagaa aatactgaaa cctgagtcgc 398821 ggcgcgggtc ttctttcgtg taaagatccc caactacgct tgaaacgttt ggttttaata 398881 agcctgttcc gacaatgata agcaccatac tgatatagaa tgctatcgaa ctgcccggat 398941 aggcgagtgc aatgtggccg aacataatga atatgccgcc gtaaaacacg gtgtttgcgg 399001 taccgaatac ccggtcagcg agccatccgc caataatggt ggacatgtat acgagtgatc 399061 cgtaaatcga cataatggca accgcagtgc ccttgtcaaa gccgagccct ccgtttaccg 399121 tctctgtata caaatagtaa agtaagattg ctctcattcc atagtaagag aaacgctccc 399181 aaaattcggt gaaaaatagt gtaaatagtc ctcgcgggtg accaaagaac cctttttgcg 399241 ggacgctttt aatgatactt tcgttatcaa tcgaagccat gtcagccaaa ccctttctaa 399301 aaaaagtgta ttataaaaat catattctta tataatactt gtgtcaatat aatttatact 399361 catttcaaat agttccatat tggaaaaatt ataaatacct aaaaatagtg atttcctcct 399421 aatttttaaa ctttttatcg tgagattttc ttacacaact attcctttat atttttttaa 399481 taaaatttta gagaaatgta caagcagatc gggaggaccg ctggtgaatc aatcccctgt 399541 aacggggatt tttttatgtc cgtaaaccgc tttgaaaagc cgctgcacac cctcctgaat 399601 atcttcttcc ttcagccgtg caaagccgat aatgagagca ggcctgcccg tttgccgctt 399661 gttttccttc aagttaaatc ggctcattcc gaatatttca agctgcagcc cggcagcatg 399721 tgacaggatg tcttgttcgg tgcgcctggt atcaaattcg gtaacaaaat gcagccccgc 399781 atttgcccct tttacggtaa cctctccgct gaactctgct tctaaagcgg tgatcaggcg 399841 ttctctcttt tctttataat gctgcttcat tttttttata tgcttctgat attcaccaga 399901 ctcgataaat tcctgcaggg tgagctgtgt gagtgatgag caagtctgca gatcatagcc 399961 ccgctgtttg tatgccctca acagctcagg cggcaacacc atatagctga tccgtaagcc 400021 ggggagaagg gactttgaaa aggttcccat atagatgaca ttttgaaaac ggtcgaggct 400081 ttgcagcgcc ggaatactgt ctacatcata tgtgaattca ctatcataat cgtcctcaat 400141 gatatatcgg cgcggctcct cggctgccca gttcagcagc tgaattcttc tggatacagg 400201 cataatcgtt ccggacggaa actgatgcga cggggtggtc accagcacat ctggctgctg 400261 tctggtgatt tcagcaatcg acatgccttt ttcatccagc atgatcgtct ttacttgttt 400321 tccggcattc ttcaaaagct gatacatgcg cctgtagcca ggctcctcca tcgcatacac 400381 ggcttccttg ggtaaaagct cagtcaacag ctgcatgagc acctgtgtgc ctgcccctat 400441 gatcatttgt tccggcctgc attttacacc cctcgtcagg gaaatgagcc tcgtaatggc 400501 cgctctcact tcatatatcc cttgcggatg tgacatatcg ccgagcgtgc ggtatgagcg 400561 ggaggccgct ttttgctcgc agcggaacca gcttttgatc ggaaaatggt ctgtatcgga 400621 actcatgtgt gaaaacgata tccaatcgct ctggtcgatg tgaatctctt ttaggtcatc 400681 cggcagtgca aatggagggt gctcctcggc ggaaaacatg tctagttcct ccacgaagaa 400741 accctttcgt tcaatggcgt acaaataccc ctcagccagc agctgctgat aggctgaatt 400801 cactgaattt acgctgacct tgagattttc agccagctcc cgcttggagg gaaccttcga 400861 gtgcggcagc agattgcggc tgaggatttc ttttttcagc ttttgataaa tttgctgata 400921 gatataatcg gcttgttctg aacgatcgag tgtaatcgtg atatccattt tgtagtttct 400981 ccttctgata ccatcaaaaa gttataattg gtacttttca tcataccaaa gagaagtcag 401041 aatgataaga aaataccgac agggggatat tcacatgagt caaacaacag caagcatcac 401101 aactgcacaa tggcagcaaa aacgggatca atttgtgtca aaaggtgtga gcaacggcaa 401161 ccgcagtctg gcggtcaaag gagaaggggc cgagctgtac gatctggatg gccggagatt 401221 tattgatttt gcaggcgcca tcggcacgtt aaatgtcgga cactcgcatc cgaaggtggt 401281 tgaggctgtg aagcggcagg cggaggagct gattcatcct ggttttaatg tcatgatgta 401341 cccgacttat atcgaattag cagaaaaact gtgcggcatc gcgccgggca gccatgagaa 401401 aaaagcgatt tttcttaact caggggcaga agcggtcgaa aacgctgtga aaatcgccag 401461 aaagtataca aagcgccaag gcgttgtctc gtttacacgc gggtttcacg ggcgcacgaa 401521 tatgacgatg agcatgacaa gcaaggtaaa accttataaa ttcggtttcg ggccttttgc 401581 gccagaggtt tatcaagcgc cgttccctta ttattatcag aagccggccg gcatgagtga 401641 tgaaagctat gacgatatgg tcattcaagc attcaatgat ttctttatcg cttcagtggc 401701 gcctgaaacg gtggcgtgtg tcgtgatgga gccagtgcag ggagaaggcg gatttattat 401761 tccttcgaaa cggttcgtac agcacgtcgc ttcattctgc aaagaacacg gcattgtttt 401821 tgttgctgat gaaatccaaa ccggctttgc cagaactggc acttatttcg caattgagca 401881 ctttgatgta gtgcccgatc tgatcacggt ttctaaatcg cttgcggcag gcctgccatt 401941 aagcggtgtg atcgggcgtg cggaaatgct tgatgcggca gcgccagggg agctgggcgg 402001 cacgtatgcc ggcagcccgc tcggctgcgc ggcggctttg gcagtcttgg atattatcga 402061 agaagaagga ctgaatgagc gatctgaaga aattggcaaa atcattgaag acaaggcgta 402121 tgagtggaaa caagaattcc cgttcatcgg tgacatccgc agactcgggg cgatggccgc 402181 aatcgaaatc gtcaaggatc ctgacacgcg tgagcctgat aagacaaaag cagcagcgat 402241 cgcggcctat gcgaatcaaa acggattact tttgctgaca gcgggaatta acggtaatat 402301 catccgcttt ttgacaccgc tcgtcatctc agacagccta ttaaatgaag ggctcagcat 402361 cttggaggcg ggcctgcgag cttaatcatt ggaaagaaaa tggccgggtc tgctatcatt 402421 ttaagtaatc atgaaaagaa aggaatgttc aatatgccag atcaattaac ggtctacaac 402481 ccggctacgg gcgaggagat caaaacgatt cctcagcaat cagccacaga ggtagaagaa 402541 gccattgaac gttcacatca agcgtttaaa acgtggtcta aaacatcagc gaacgaaaga 402601 acgtctcttt tgaaaaaatg gtatgagctg attgttgaac ataaagaaga gcttgcagat 402661 ttaattacaa aggaaaacgg aaaaccatac caggaagcag tcggcgaggt actttacggc 402721 gcaggctata tcgaatggtt cgcagaggaa gcgaagcgtg tgtacggaag aacggtcccg 402781 gccccgacaa ctggtaaacg aattgttgtc acacgccagc cggtcggccc cgttgctgct 402841 atcacgccct ggaatttccc gaatgcgatg attacacgca aagcggcgcc tgctcttgcc 402901 gccggctgta catttatcat caagccggcg ccggacacac cgctgtctgc ttatgaacta 402961 gcgcgcctcg catatgaagc gggcattccg aaggatgttc ttcaggttgt gatcggcgat 403021 ggagaagaaa tcggaaatgt gttcacaagc agtccgaaaa tccgcaaaat cacgttcaca 403081 ggctcaacac ctgtagggaa aatccttatg aaaaacagcg ctgacaccgt aaagcacgtc 403141 tcaatggagc tcggcggaca cgccccgctg atcgtagatg aagatgcgga cattgacctt 403201 gccgttgaac aggcgatggc gtccaaatac cgaaacgccg gccaaacctg cgtatgtgcc 403261 aaccgcctga tcgttcatga atccattaaa gatgaatttg ctgcgaaact gagcgagcaa 403321 gtgtctaagc tgaaagtcgg aaatggactt gaggaaggcg tcaatgtcgg cccgattatc 403381 aacaaacgag gcttcgaaaa aatcgtcagc caaatagatg atgcggttga aaaaggcgcg 403441 aaagtgattg ctgggggcac atatgaccga aacgatgaca aagggtgcta ctttgtgaat 403501 ccgacagtgc tcaccgatgt cgatacgtcc atgaacatca tgcatgagga aacattcggc 403561 ccggtcgccc cgatcgtcac gttttctgat attgatgaag cgattcagct tgccaacgat 403621 acaccgtatg gcttggctgc ttacttcttc acagaaaact accgccgcgg catctatatt 403681 tccgagaatc tagagtatgg cattatcggc tggaatgacg gcggaccgtc agcggttcaa 403741 gcgccattcg gcggaatgaa agaaagcggc atcggccgtg aaggcggttc agaaggtatc 403801 gagccgtacc ttgaaacaaa atatttgtcc atcggtttat aaaagaatgc acgctcctga 403861 gagctgccgg attttccggc agctcttttt gtgttccggc gaataatcac aacaattcca 403921 gccaaaataa cagcaaatac attttgaaag aaggttcccc aacaatggat ttattattgg 403981 ctcttctccc ggctttgttt tgggggagca ttgttctctt caatgtgaaa ttaggcggcg 404041 ggccgtacag ccagacactg ggaacgacga tcggggcact cattgtttct atcgttattt 404101 acttttttgt tcagcccgtt ctgtcccttc gcatttttat tgttggaatc gtatccggct 404161 tattttggtc acttggacag gccaaccagt tgaaaagcat tcaattgatg ggcgtgtcga 404221 aaacaatgcc gatttccaca ggaatgcagc tcgtttccac ctcgctgttc ggtgtgatcg 404281 tgttccgcga atggtcaaca ccgattgcga ttacgcttgg cgttctcgct ttgatcttta 404341 tcattgtggg aatcattctc acgtccttgg aagataagaa tgataaaaaa gagggcgagc 404401 caagcaattt gaaaaagggc attttgattc tccttgtttc gactcttggt tatttggttt 404461 atgtagtcgt ggctagatta ttcaatgtgt ccggctggtc cgcgctgctg ccacaggcaa 404521 ttggcatggt ggtcgggggg ttagttttaa cctatagaca caaacccttt aacaagtatg 404581 cgatcagaaa tattctccca gggttaatct gggcaggcgg aaatatgttt ttgtttattt 404641 ctcagccgcg agtcggcgtt gcaacgagct tttccctttc acaaatggga attgtcattt 404701 ctacgctcgg cggtattttc atcctgcgtg aaaagaaaac gaaacgccag ctaatagcaa 404761 ttgcgatcgg gattatcctg attattgccg ccgccgtatt cttaggaatc gccaaaacaa 404821 attcataaca aatggaggag gatgtatatg tatccggatt taaaaggaaa agtcgtcgct 404881 attacaggag ctgcttcagg gctcggaaag gcgatggcca ttcgcttcgg caaggagcag 404941 gcaaaagtgg ttatcaacta ttatagtaat aaacaagatc cgaacgaggt aaaagaagag 405001 gtcatcaagg cgggcggtga agctgttgtc gtccaaggag atgtcacgaa agaggaagat 405061 gtaaaaaata tcgtgcaaac ggcaattaag gagttcggca cactcgatat tatgattaat 405121 aatgccggtc ttgaaaatcc tgtgccatct cacgaaatgc cgctcaagga ttgggataaa 405181 gtcatcggca cgaacttaac gggtgccttt ttaggaagcc gtgaagcgat taaatatttc 405241 gtagaaaacg atatcaaggg aaatgtcatt aacatgtcca gtgtgcacga agtgattcct 405301 tggccgttat ttgtccacta tgcggcaagt aaaggcggga taaagctgat gacagaaaca 405361 ttagcgttgg aatacgcgcc gaagggcatt cgcgtcaata atattgggcc aggtgcgatc 405421 aacacgccaa tcaatgctga aaaattcgct gaccctaaac agaaagctga tgtagaaagc 405481 atgattccaa tgggatatat cggcgaaccg gaggagatcg ccgcagtagc agcctggctt 405541 gcttcgaagg aagccagcta cgtcacaggc atcacgttat tcgcggacgg cggtatgaca 405601 caatatcctt cattccaggc aggccgcggt taaacataaa aagcgaccca gacatgacat 405661 ctggatcgct ttctttatta ggcacgcttt ttctttacaa gtgctgctac agataaaata 405721 atggcagccg cagacagcac catcgctgta atgtctagag ctgaagaacc tgagttttcg 405781 gaatcgtctt ctgttttcgt ggcgccgtgc tcatctgtca cttgctttgc agacgtgatg 405841 tttgtaatgg aatgaggtgt atcggcatcc tcgtcacctg tccactcaac aatgctgccg 405901 tctttgtaat attggtatgc gtcccaagca gcttcctccg ctttgtcagg gtttttggca 405961 acaaaggtaa actgctggaa ctggccttcc tgaatgcctc cgtcagtcgc ctcccatgtc 406021 acggatactg atttgtcatc atgtttttga gtggaaacct tccagcccgg aattggctca 406081 tattgctgga attcaacatc cttcggcatt ttgaggacaa ccttcgttgt cggcagattt 406141 ttctcagaag gaaccttcat tgtatacgtt tcccaagagc ctgcagcaga ctcagccggt 406201 tttacagaaa catgcgcgct ggcaggggcc gtaaagaata agagggagcc gacaatagcc 406261 ggacatagtg tcaatgcgat ttttttcaac aacgtaaaca ctccttaatt ggtctttgta 406321 aacatgatat tgatttcgtt aaagtcgccg gtcaggccgt ggactttgat cttccagttt 406381 cctttttcat taatcgacag gttttgatct tggaagacgc cttttgtttt ttcttttaat 406441 gtaaaggtgc ttttgttttc gctgcctgac aggcctgttt tataaacggt taacgtgatt 406501 tgctggatgt ttttcacggg atcaccgtta tggtcggtga cccgcagctc aaaaacattt 406561 tttccaggct ggtttgggct gatgctgaga gaaacgcttt gtccgttctc tatcgctttg 406621 gtttggtaga acggttccgg cgctggctca ggcgggcttg gcaggcttgt aaacacggcc 406681 gctgtgatca atacagcgat gccgattgcc cactccgctt tcaacgttcg gctgattcct 406741 gtgcggcgct gctttctggt aagcagaaaa tgaattgcgc ctaagaccag catgaaaaca 406801 aacagcccgc ttttcactaa aagagcttgt ccgtacgctg tatggaacag tgaatccatt 406861 gaacgaatga tgaaaaatcc attgagcaag cctgaaaaca aaatgacgcc gactgcagtg 406921 agcgcccatg gggagaaccg tctgaccgtc tcccacgcga gcgttttgtc aggctgcctc 406981 cattcttttg agagcagcaa aacgagtgcc gctattccgc cgacccagat ggaagcggaa 407041 gttaaatgaa ggaaatccat caaaatgccg accgtttttt cttcaacgac agcagcatgc 407101 ccggtaaacg ccttggcaag caggagaccg aaaaagaaaa tgagcggcgc tgtccaatag 407161 ccaaaggatg aaaagcggtt tttccgtatc gcagggatga cagacagtgc gagcagcacg 407221 aacagcgcag cctgtatgat ccaaatggag ccgcctgctg tctcaaacag tgtttctctg 407281 atgtagcccg gctggaatgc gctgccccag ccgccgcctg cgttcgcttt tgtctgaatc 407341 ggaagctgaa gcaaaagcgc cagccccaat gctgcgatcg agccggtcag gatacgtctc 407401 gtccgtttga cgagctgttc tgatttccct ttataccaga aaagatggaa gaaaaccgtt 407461 ccgataaaca gagataaggc tgtatacaga atcgcgcgat ctgctgctgt tcccggattc 407521 agcgctgaat cggctgcttt ttggctgctg aatccgccat ccgctttccc gatactgaac 407581 ggaatgacgc cggaaacagg atgtccatcc gcggatacgg cattccattc cgctctgtac 407641 acatctttag gcagattctt cttcagcttc actgtcatga tgtgatgatt atcttttttg 407701 atttcagtct tgtccgtatc cacacggtcg ccgtttgaat tatagacttt aatgtaatga 407761 aacccttctt caaccggttc attaaattcg atttccacct gcgcaggggc gctttttaat 407821 tcgctgtttt ccccaggtga agatttgaca atataggcgt gagcaaagct tgttttcggc 407881 aggaaaacaa gaaaaagcag aaggatgatc caccatctgt ttcgcttcat cactcagaca 407941 ccaccttccg ctgtatgtgt tgtgttattt cttggtgcag gtgcagcgtt tctttcggtc 408001 ttgaagcatg tcttccagcg cttggtcgaa agtgcagacg gctccgccga atcctttttg 408061 aaatcgttcg gcatggtcaa gtgtcgcaaa cggaatggcc tgcggctggc agcagtgcag 408121 gtttaattca gcatttacga cgaaataagc cgaaccggca ctgacggttg tctgtaacag 408181 aaaatctctg caaatcaagt gtgaaacctc ttccgtttta tccgcgtaac gcaaaaacgc 408241 gcaatgtgcg cagcatagct gttcaatgtc ttggtttacc gtaatcagct gaaccgaatg 408301 agcttgattg acgggcttca agcaatagct gcacatatga tctgtttgag gtgttcggac 408361 ggggagcgtg atgccgccgg ccgttttaat gacctgattt gactgaacca gctgattgac 408421 atctctatat accgtcattt ccgaaacgcc gaaccttgcg ctgatgtcag aaattctaag 408481 cgagccttct tctttcagcc acttcagtat gtgttgctgt ctattaatcg gaagcattca 408541 tacaccctct tcattaagat ctatttaagc gtagaggatt ttagagacgg agacaagtaa 408601 gtggatgata aaaaatgtga aaatgtgttg aacagcaaca aaacgaaaca gaagggactc 408661 tggtataata gacagatgga atagaaagtg aggaataccc tatgaaagaa acaccatgcc 408721 cgaactgcgg caaacctttg acaggcgata tggtcagatc atcaaatgtg ccttgtcaat 408781 ttcgctgcgg ccactgccgg gaacggcttt atgaatataa agtttcagct ccgattatgc 408841 tggtatcatt agcggccatc gtgctgctta tttatctttt gatgctcctc cgcaatgcgg 408901 caggctcagt gctgccagct gtacagcacg tgccgatggc tgtatttgcg cttgtgtgcg 408961 cgtatcccgt ttttattgtg agtgagcgga tgattgcaaa gtacgtgatt caaaatggca 409021 acatcattta tagaggaaag agaaaaggct cctgaaacca ggagcctttt tatttttaaa 409081 aaattgtcac agtcatgtgc caaagtcctc tttactttca attgtatagg gactgtaagc 409141 gttttaacat agagtcaaag ggaagcatca ttctctgaac atatttttgt atcttacagc 409201 gacaaacaaa acagggaggg tttatatatg cagcagcaag aacagcagca aggcggcatg 409261 aaagtgaaag tgcaacgctt tgggagttat ttgagcggaa tgatcatgcc gaatatcggc 409321 gcgtttatcg cgtggggtat cattaccgcg ctgtttattc cggcaggatg gtttccgaat 409381 gaacagctga acacgctggt cagcccgatg attacgtatt tattgccgct tttgatagcg 409441 tatacaggcg gaaaaatgat ctacgaccac cgcggcggag ttgtcggagc gacagcggca 409501 attggggtga ttgtaggatc ggatattcca atgtttttag gcgcaatgat tatgggtccg 409561 cttggcggat acctcattaa acagactgat aaattattca aggataaagt caagcaaggc 409621 tttgaaatgc tgatcaacaa ctttacggca gggattgtcg gcgcggcttt aacgattctc 409681 gcgttttacg ccatcggccc ggttgtcttg acgctaaata aattgctggc ggctggtgtg 409741 gaagtcattg tacacgctaa tttactgccg gtagccagtg tttttgtaga accggcgaaa 409801 gtgttgttcc ttaacaacgc cataaaccat ggaatcttaa gcccgatcgg aatcgagcaa 409861 gcatctcaaa caggaaaatc aattctgttt ttagtagaag caaaccctgg accggggctc 409921 ggcattttgc tggcctacat gttctttggc aaaggatctt caaaatcaac ggctcccggt 409981 gcggcgatca tccatttctt cggagggatt cacgagattt acttcccgta cattctgatg 410041 aaaccggccc tgattctcgc agccattgcc ggcggagcaa gcggactctt aacatttacg 410101 atctttaatg ccggacttgt cgcggcagcg tcaccgggaa gcattatcgc attgatggca 410161 atgacgccaa gaggaggcta tttcggcgta ttggcgggtg tattggtcgc tgcagctgta 410221 tcgttcatcg tttcagcagt gatcctgaaa tcctctaaag ctagtgaaga agacctggct 410281 gccgcaacag aaaaaatgca gtccatgaag gggaagaaaa gccaagcagc agctgcttta 410341 gaggcggaac aagccaaagc agaagaagcg tctgagctgt ctcctgaaag cgtgaacaaa 410401 attatctttg cgtgtgatgc gggaatggga tcaagtgcca tgggggcatc catcttaaga 410461 aacaaagtga aaaaagcgga gcttgacatc agtgtgacca acacggccat taacaatctg 410521 ccaagcgatg cggatattgt catcacccac aaagatttaa cagaccgcgc gaaagcaaag 410581 ctgccgaacg cgacgcacat atcagtggat aacttcttaa acagcccgaa atacgacgag 410641 ctgattgaaa agctgaaaaa gtaatcttat agaaagagag tgattgtcat gcaagtactc 410701 gcaaaggaaa acattaaact caatcaaacg gtatcatcaa aagaagaggc tatcaaattg 410761 gcaggccaga cgctgattga caacggctac gtgacagagg attacattag caaaatgttt 410821 gaacgtgaag aaacgtcttc tacgtttatg gggaatttca ttgccattcc acacggcaca 410881 gaagaagcga aaagcgaggt gcttcactca ggaatttcaa tcatacagat tccagagggc 410941 gttgagtacg gagaaggcaa cacggcaaaa gtggtattcg gcattgcggg taaaaataat 411001 gagcatttag acattttgtc taacatcgcc attatctgtt cagaagaaga aaacattgaa 411061 cgcctgatct ccgctaaaag cgaagaagat ttgatcgcca ttttcaacga ggtgaactga 411121 catgatcgcc ttacatttcg gtgcgggaaa tatcgggaga ggatttatcg gcgcgctgct 411181 tcaccactcc ggctatgatg tggtgtttgc ggatgtgaac gaaacgatgg tcagcctcct 411241 caatgaaaaa aaagaataca cagtggaact ggcggaagag ggacgttcat cggagatcat 411301 tggcccggtg agcgctatta acagcggcag tcagaccgag gagctgtacc ggctgatgaa 411361 tgaggcggcg ctcatcacaa cagctgtcgg cccgaatgtg ctgaagctga ttgccccgtc 411421 tatcgcagaa ggtttaagac gaagaaatac tgcaaacaca ctgaatatca ttgcctgcga 411481 aaatatgatt ggcggaagca gcttcttaaa gaaagaaata tacagccatt taacggaagc 411541 agagcagaaa tccgtcagtg aaacggtagg ttttccgaat tctgccgttg accggatcgt 411601 cccgattcag catcatgaag acccgctgaa agtatcggtt gaaccatttt tcgaatgggt 411661 cattgatgaa tcaggcttta aagggaaaac accagtcata aacggcgcac tgtttgttga 411721 tgatttaacg ccgtacatcg aacggaagct gtttacggtc aataccggac acgcggtcac 411781 agcgtatgtc ggctatcagc gcggactcaa aacggtcaaa gaagcaattg atcatccgga 411841 aatccgccgt gttgttcatt cggcgctgct tgaaactggt gactatctcg tcaaatcgta 411901 tggctttaag caaactgaac acgaacaata tatcaaaaaa atcatcggtc gctttgaaaa 411961 tcctttcatt tcggacgatg tgacccgcgt agcgaggtca cctctcagaa aactgggaga 412021 aaatgataga cttgtaggcc cggcaaagaa aataaaagaa ccgaatgcac tggctgaagg 412081 aattgccgca gcactgcgct tcgatttcac cggtgaccct gaagcggttg aactgcaagc 412141 gctgatcgaa gaaaaaggat acagcggcgt acttcaagag gtgtgcggca ttcagtccca 412201 tgaaccgttg cacgccatca ttttaaagaa acttaatcaa taaccgacca cccgtgacac 412261 aatgtcacgg gcttttttta ctatctcgca atctagtata atagaaagcg cttacgataa 412321 caggggaagg agaatgacga tgaaacaatt tgagattgcg gcaataccgg gagacggagt 412381 aggaaaagag gttgtagcgg ctgctgagaa agtgcttcat acagcggctg aggtacacgg 412441 aggtttgtca ttctcattca cagcttttcc atggagctgt gattattact tggagcacgg 412501 caaaatgatg cccgaagatg gaatacatac gcttactcaa tttgaagcag tttttttggg 412561 agctgtcgga aatccgaagc tggttcccga tcatatatcg ttatgggggc tgctgctgaa 412621 aatccggagg gagcttgagc tttccattaa tatgagaccc gccaaacaaa tggcaggcat 412681 tacgtcgccg cttctgcatc caaatgattt tgacttcgtg gtgattcgcg agaacagtga 412741 aggtgaatac agtgaagttg gcgggcgcat tcacagaggc gatgatgaaa tcgccatcca 412801 gaatgccgtg tttacgagaa aagcgacaga acgtgtcatg cgctttgcct tcgaattggc 412861 gaaaaaacgg cgcagccatg tgacaagcgc cacaaagtct aacggcattt atcacgcgat 412921 gccgttttgg gatgaagtct ttcagcagac agccgctgat tatagcggaa tcgaaacatc 412981 atctcagcat attgatgcgc tggccgcttt ttttgtgacg cgtccggaaa cgtttgatgt 413041 cattgtggcg agcaacttgt tcggtgatat tttaaccgac atcagctcaa gcctgatggg 413101 aagcatcggc attgcgcctt ctgcgaacat caatccatcc ggcaaatatc cgtccatgtt 413161 tgaaccggtt cacggctcag ctcctgacat tgccggacag ggccttgcca atccgatcgg 413221 ccagatttgg acagcgaagc tgatgctcga ccacttcgga gaggaagaat tgggggcgaa 413281 aattctggat gtaatggagc aagtgactgc cgacggcatc aaaacacgcg acattggggg 413341 acaaagcaca acggctgagg tcactgatga aatctgttcg cgcttaagaa agctctgatg 413401 aatcaggccg gtggcagatg gctgccccgg cctgtccatt tccttacgaa aatttccacg 413461 aaagtctaac caagcagatc caaatgctgt ataataattt ggaattctta ggaaagcatc 413521 gggtgaagga agttgaatgc aaaaacaatc acgttaaaga aaaaaagaaa aatcaaaacg 413581 atcgttgtac tcagtatcat tatgatcgca gctctcattt ttacgatcag attggtgttt 413641 tacaagcctt ttcttattga aggatcatca atggccccaa cgcttaaaga ctcagaaaga 413701 attctggttg ataaagcagt caaatggact ggcgggtttc acagaggaga catcatagtc 413761 attcatgaca aaaagagcgg ccgctcattt gtcaaacgtt taatcggttt gcctggtgac 413821 agcattaaaa tgaaaaatga tcagctatac ataaatgata aaaaggtgga agaaccatac 413881 ttaaaggaat ataaacagga ggtcaaagag tcgggtgtaa ccttaacagg tgacttcgaa 413941 gttgaggttc cttccggtaa atattttgtg atgggagata accgtctcaa ttcactggat 414001 agcagaaacg gaatgggcat gccttctgag gacgatatca tcggtactga atctctcgtc 414061 ttttatccat tcggtgagat gagacaggca aaataaaatg caatgcaaaa agaacatgga 414121 acatgacggc accgataata aagcgccgtg cacgtttaaa aaaatgatga tgaaacggtg 414181 cggagccggc tttccgcccc gttttttatg atagaaagcg ttttgaagaa aagggccctg 414241 ttgaaataaa cagaatcagg attggcgaag ccgtgaagcg catcgaattg gtaaatctca 414301 agatgggtat gctgtttttc ccgcagtttt ttgataagaa gcgctacgtc aaacgacggc 414361 tcataattag ggaaaaacaa taggaccggg caggctggca tgtgatgaag agagtcgcgt 414421 atccgggaac cgtaataaca aaccgatccg ctcacctcag gcatactgct gcatttccat 414481 gcgatagtag cccccacgct gaatccaatc acaaagatgt gccgtccggc gttttgcctg 414541 atcacattct ggatgatggt ttctcccgtt ttcagccttt cgtgttttgt aaattgttcg 414601 tatgccgttt tttcttcttt cagtgtgtag acttcatcct cgccgagcag gttgggcgtc 414661 aacacatcat atccagccat tttgatcagc cggcccatct ttttcatatg gctgtttaca 414721 ccatatattt cgtgtgcgag aatgacaagc ggttttggga acataacggc ctccttttgt 414781 gttttttcca ttatatccta tcgtttcact ttaggctgag atataatggt caaaaaaagg 414841 agatataaaa tgaactcatt atctttgcct caccgctatc catttttgtt tattgatggc 414901 gtgacggata gcgagcccgg caaacatgcg gcagcttata agctgattag tgagaacgac 414961 tggtttatca ctgatacgca aacagaaatg ccgttttcac ttgtgattga agcgcttgcg 415021 caaaccgcgg cttttacagg aattacagat gagaacagct tgggattatt gtcttcggtg 415081 aagaaagcgg aaaagctggg agaagctgtg cctggtgacc ggcttgatct tacgtttgaa 415141 gtcacgcgca atcggcgcgg gtttgtgttc ggacatgcca aggcatcagt tggagagcag 415201 cctgttgctg aagctgaaat cggcatctat attgaaaaat gaaaaaaacc cttcacaaca 415261 ttttgtgagg ggttctattt tgtgtcgtaa tcccgttcgc tttgagagtt atctctttgc 415321 tggcgtttgt gtttttcatc attcatattt tccttcagct cttcattagg aatcggatcg 415381 gttaagtcgt tgtgctcggg gttttcattt ggtttgtttt gctgtttttt ttctgtcatg 415441 tttgatcacc tcaccgtttg ttttcctctt attcattctc ctcaaacata ggaaatcgct 415501 tttttgtccc gctgggtata atgtattaga atagagagaa gcacaacaaa aagataaaga 415561 gaggtacata tatgtctgtt caaagagaag atgtagatat caagctgatc gcaattgata 415621 tggatggtac actgctgaac gacgagcagc tgatctcgga tgaaaaccgc aaagccattc 415681 gtgaagcgga ggataaaggt gtgtatgtgg tgatcagcac gggccggacg ctgatgacgt 415741 gcagggagct ggcggaatcg ctaaagctgt catcctttct aatcacggca aacggcagtg 415801 aaatttggga ttcgaatttt aatttggtgg aacggaagct gcttcatacg gaccatattc 415861 aaatgatgtg ggatttgcgg aataagcaca acactaattt ctgggcttct acggtgaata 415921 aagtatggag aggcgagttt ccggaaaaca ttacggatca tgaatggctc aaattcggct 415981 ttgacatcga ggatgacgat atccgaaacg aagtgcttga ggagctgaga aaaaacaaag 416041 agctcgaaat cacaaattca agtccgacaa acattgaagt caacgcgctt ggcatcaaca 416101 aagctgcagc ccttgccaag gttacggaaa aactcggctt tacaatggag aatgtgatgg 416161 cgatgggcga cagccttaat gacattgcga tgatcaaaga agcgggtctt ggcgtcgcaa 416221 tgggcaatgc gcaagacatc gtaaaagaaa cggctgatta tatcacggat acaaatattg 416281 aggatggtgt cgctaaagcg attcgccatt gggtactata aaaaaagaga gtcctaagat 416341 ggactctctt ttttagtttg gcaggtttta ttctgggacc atggtaggtt ttctgacaaa 416401 agtatttcac aaactgatat gattcactta taatgaaata aagttcaaaa attcggaata 416461 gtcgttccga atttcgggac aataaatgac ataaagcata tcgtttgctt tggcaggagg 416521 gattctgtgt ttcagattga tttaaactgt gatttaggag aaagcttcgg agcctacaag 416581 ataggccttg accaagatat tttagagtat gtgacatcag cgaatatcgc atgcggattt 416641 catgcaggag atcctagtgt tatgcgaaaa accgtcgcgc ttgcagcaga aagaggcgtg 416701 aaaatgggtg cgcatccggg cttgccggat ttactcggtt ttgggcgccg caatatggcg 416761 atttctcctg aggaagcgta tgatcttgtc gtttatcaaa ttggcgcgct ctctggcttt 416821 ctaaaagcag agggacttca catgcagcac gtcaagccgc atggcgcttt atacaatatg 416881 gcggcagtcg atcaaaaact gtcggatgct atcgcgaaag ctgtctataa ggttgatccc 416941 ggcctgattc ttttcggtct tgctgagagc gagcttgtaa aagcgggaga acggatcgga 417001 cttcagaccg caaatgaagt gttcgccgac agaacatacc aatcggacgg cacgctgaca 417061 ccgcgctccc agccggacgc actcattgaa agtgatgatg ccgccgtcac ccaggtcatc 417121 aaaatggtga aagaaggggc ggtcaaatct cagcaaggac atgatgtgtc attaaaagca 417181 gatacagtct gcattcatgg agatggagcc catgcgctga catttgcgca aaaaatcaga 417241 aaacagctca aagcggctgg aattgaagtg acagctattt cagaacagag gtcaacataa 417301 aggaggaaca atagatggag cagcagaaaa agacagcagg aaaaaaagcg ggcagctggt 417361 cattgctgat gggcgccgcc tttttaatgg cgacatcagc aatcggaccg ggtttcctca 417421 cccaaaccgc aacattcaca aacacactcg cagcaagctt cggttttgtc atcttaatct 417481 ctattatttt agatattttc gcccaaacca atgtgtggcg catcatcgca gtttctggaa 417541 aacgaggtca ggaaattgcg aatatggtgc ttcccggact ggggtatttc atcgccattc 417601 tcgtcgtgct tggcggacta gcttttaata ttgggaatat cggaggggcc gggctgggac 417661 ttcaggtgct gttcggcatt acacctgaaa caggcgcttt aatcagtgcc gttatcgcca 417721 ttttgatttt tgtcatcaag gaagcaggaa aagcgatgga ccgttttacg caaatcgcgg 417781 ggttcgtgat gattatttta acggtctacg ttgcggcgac gacagctcct ccggtcggac 417841 aggcagtcgc aaatacattc gtcccggaac acatcagcat atttgccatt gtcaccctag 417901 tgggcggaac cgtcggcggt tatatcacat ttgccggagg acaccgtttg cttgatgccg 417961 gaattaaagg aaaggaatcc attccgcagg tgacaaagag ctcggttgtc ggcattttaa 418021 ttacatctgt catgcgtatc gctctttttc ttgcggttct aggcgttgta tcgaaaggcc 418081 tgcacatcga tgaaagcaac ccggcggctt ctgtcttcaa gctggctgct ggaaatgtcg 418141 gttataaaat tttcggattg atcatgtggt ctgcggcgat tacgtctgtt attggagcag 418201 cctatacatc tgtttcattt tttaaaacct tttctccaaa aattgaaaag aattcacgcg 418261 gtattattat cggatttatt gtggtttcta cgttagcttt tgtcacaatc ggccagcctg 418321 cgaagatcct cgtccttgtc ggttcactga acggcttaat tctgccgatt gcgctcggaa 418381 cgctgcttgt tgccgcctac aagaaaaaca ttgtcggtga ttataagcat ccgctttggc 418441 tgacaagcac aggcgcgctt gtagtgattg taatggcagt tatgggaatc tacacgttat 418501 gtacacaact tcctcaattg tggagctgat ataagtggag caattaaaca aaatggcgcc 418561 aaaggatgta cgcgccctga tacgagaggg gaaaataaac gggccgaccg caggcatgtc 418621 cggcggctac gcccaagcga atcttgtggt tttgaaaaag gaccttgcgt ttgattttct 418681 gctgttttgc cagcgaaatc aaaagccctg ccccgtgctg gatgtgactg aagcaggttc 418741 gcctgtgccg tctctggctg cgccggatgc tgatatcaga acggactttc cgaaataccg 418801 tatttacagg cacggtatcc taacggaaga agtatctgat attacgccat actgggagga 418861 cgattttgtc ggctttctga tcggatgcag tttctccttt gaacaggcac tgatcaataa 418921 tgggatagct gtccggcata ttgatgaggg gacaaacgtc tcaatgtata aaacgaatat 418981 cgattgtgtt ccggcggggg cgtttcacgg acagatggtt gtcagcatga ggccggttcc 419041 tgaacggctg gctgtacgtg ctgcacaagt gacctcgcgt tttccggctg tgcacggagg 419101 gccgatccat attggcaatc cgggagcaat cgggattcgc gatctcggga aaccggattt 419161 cggagatgcc gtttccattc gtgacggcga ggttcctgtt ttttgggcat gcggagtgac 419221 cccgcaagcc gtggctatga atgtaaagcc tgaaatggtc atcacacatg cgccggggca 419281 tatgctcatc acagatattc gagacgagtc gcttgcggtg ctgtagcctc tcgtcatcct 419341 gatgaacgag aattaaaaga ggtgagaaag atgactgtac gatatcaaat cgaacagctc 419401 ggtgattctg caatgatgat ccgattcgga gaagaaatca atgaacaggt caacggcatt 419461 gtccatgcag cggccgctta tatagaagaa cagccatttc cgggattcat tgaatgtatc 419521 ccggctttta caagtctaac cgtattttat gatatgtatg aagtgtacaa gcatttgcct 419581 caaggcataa gctcaccttt tgagagtgtc aagcgcgatg tcgaagagcg gctggcagaa 419641 atagccgaag actatgaggt caaccgccgt attgtagaaa ttcccgtttg ctatggcggt 419701 gaattcggtc cggatttaga agaggtggcg aagatcaatc aactgtcacc ggaggaagta 419761 atcgacattc atacaaacgg tgaatatgtg gtgtatatgc ttggcttcgc gcccggtttt 419821 ccttttctag gcgggatgtc aaaacgcatt gcagctccga gaaaatcatc gccaagaccg 419881 tcgattcccg caggttcggt cggtattgcg ggattgcaga caggcgttta tccgatttca 419941 acgccgggcg gctggcagct gatcggcaaa acgccgctgg ctcttttccg gccgcaggaa 420001 aacccgccga cattgctgcg ggcgggagat attgtgaaat tcgttcgcat ctcagaaaaa 420061 gactatcacg cctataagga ggagtccaat tgagcatgaa agtattaaag cccggactgc 420121 tcacaacggt tcaggatata ggcagaacgg gttaccaaaa atacggcgtt ctggccagcg 420181 gcgctatgga cacggtttca ctgcgcattg ccaatctgtt gataggaaac ggcgaaaatg 420241 aagcaggtct cgaaataacg atgatggggc ccggtccgtc gtttcatttt tcaaaacaga 420301 cactgattgc tgtgacaggg gcggacttca cgctgcgtat taatgacgag gaagcgcctt 420361 tatggaagcc tgtgctcatc aaggaaaaca gcacggtcag ctttggcccc tgcaaactcg 420421 gcagccgtgc ttatttggcg gcagctggcg gcattgaggt gcctgccgtc atggaaagta 420481 aaagcacata cgtcagagga agcattggcg gacttcatgg cagagcgctt caaaaagaag 420541 atgaactgaa cattggagag atgtcagctc tttcgcaaac catcctttct cgcttaagtt 420601 cgcagcttgg aaaacaggga tttgcagcac cgaagtggtc agtcagccgc ggcagatttc 420661 tgccattgaa gaagaatccc gtcattcggg tgctggaagg aaagcaattt gcctttttca 420721 cagaagaatc aaaaacgcgt ttttatgaag aagcatttcg tgtcacgccg cagtccgacc 420781 gtatgggcta caggctcaaa ggagaaccgc tcgaactgaa ggccccgctt gagatggtgt 420841 cggaagcggt ttcattcgga acagttcagg tgccgcctga cggcaacccg attatcctgc 420901 ttgcagaccg gcagacgact ggcggctatc cgaggatcgc gcacatcata tccgctgatc 420961 ttccgattgt ttcccaaatc atgccgggcg agcacgttca gtttgagcct gtgtccctcc 421021 aggaggcaga agcgcttgcg gtagaacggg aacagcatat aaaagaactg aaaacgagaa 421081 tgaagatgga atggctgaca tagcaaaggg gatgaatgat gcagaataaa aataaaaccg 421141 tagtcaaatc tatggcgctg cttaatttgt ttttgcataa accaagccta accttaagtg 421201 aactggtgtc gctgacggga atgccgaaga cctctgttca ccggatggtc agctccttgg 421261 aggaaatggg gttcctcagt cgggatgcgt ccggcgctta ttcgctggga ttggtgtttt 421321 tggaattcgg acagcttgtc gctgacaggc tggatatcag aaaaatagcg aaaccggtga 421381 tggaagagct gtgccgggaa gtggatgagg ccgtgcagtt gatcatgagg gacggcaatg 421441 aagcgatata cgttgagaaa atagaaggga cacagactgt gcggctgtat acggcgatcg 421501 gcaggcgttc ccccctatac gcgggagcgt gcgccagaag cattctgtcc tttcttcccc 421561 gtgaagaaat cgaagcatac atcaaacaaa ccgagctcat ttcgattggc tccggaacga 421621 ttaccgatcc cgaaaaactg cttcaggaga ttgatgcctc tgtgcaaaat ggctatactg 421681 tcagctattc agagctcgaa aactatacgg cggcgatcgg cgccccgatc tttaaccatg 421741 agcgccaggt ggcagccggc attagcattg caggctttga agcgagattt acagaagaca 421801 ggctgcccta tttaacagaa aaggtgaagg acgccgcttt acagatttca agaaaaatag 421861 gatatacata agtagccaat cttttctctg ctgcgtacat taacgtatcg acgttcaaga 421921 gtggaggaaa gaacatggtg cttcgatata cagctctggg cgattccttg acgacaggga 421981 gaggctccgg gctgttttca cccggcttcg tccagcgttt tggggacatg atggaagctg 422041 acttgaaaac aagaacggca ataaacatat ttgccagatc aggtctgaat acagaagaga 422101 ttttgggact cctgtcatat ccctatgtgc aaaaatgtat tcgagatgct gatatgataa 422161 cgatcacagg gtgcggaaac gatctcatcg attcggtctt agcctaccaa acctctaagg 422221 atgaaacgat tttcagccgt gtatccgccc attgccatga gaattttgaa aagatgattg 422281 ccaaagtcgc cgagattaaa ggagaaaatc cttccccgta cgccattcgt gtgttcaact 422341 tatacaatcc gtttcccgaa attgatatcg ccggcaaatg gatcacttcg tttaattcac 422401 atttagaaac acttgcatca gcaccccatg tcaaaatcgc ggatgcctat agcatcttca 422461 aaggcaaaga acaggaatat ctgtcctttg acggtgtcca tccgaacagc aaaggctatc 422521 aagcgatggc tgaagccgtt cacaagctag gctataaaga attatcagtt tcatagaaaa 422581 cgcgcctcat gacaggcgcg ttttttatgt gtgatcgaaa tattaaaaga aacttaaaat 422641 tctctgtctt ctgttctaca gacaaacaaa gtgcgctaga ataatggagg gcgtaggcaa 422701 atatagccat aacgttcaat atttcgtata taaggaagga tggtcctttt gtttcggatt 422761 tttaaaatgt cttttgcggt tatcattatt atactggcgc ttattgcttt taactatacg 422821 gaacacacct ctgtaatcca atcggtcatg ctcgtctttc ttggtgcggt catgtttatg 422881 caggggcttg aagagcgcaa aaaagaaaat gacggctcag gcgcttttaa tatttatacc 422941 gccgtttttg tatggtctgt ctcccttatc ggttttacac ttcatattat ataaatctat 423001 tacacatcct gaaaatgctc gaccgtcggg aacggggtat agaaccgatg aagcaaggct 423061 ttccactctt gatactctga agaaccgcga aagccttccg tatggtcctc aagtgtttcc 423121 cactccacaa gaagcagata tttatgcgtt tcctccatgc attttgataa cgagtgagtg 423181 atatagccct tcatgccgga aataatcggc gcagcttgcc ggaatgcatc ctcaaactct 423241 tgttcaaggc cttctttaat gtgaagcatt gctgcctctc tgaccatgct atcccttctt 423301 tctgtctttt caaatagtct acagcaaacg ataggagatt tctgcaaaat cggtgaactt 423361 ttccttcatt ttcaaaaaaa tcttgcacgc accaattcaa ttaagagaaa ataacaagtg 423421 gaaggcaggg gaaagtcatg ttaaaaaagt gtattctact agtatttcta tgcgtcggat 423481 tgattgggtt aatcggatgc tccaaaacag attcaccaga ggatcgcatg gaagcattcg 423541 tgaaacagtg gaacgatcag caattcgatg acatgtatca aagcctgact aaagatgtca 423601 aaaaagaaat ctccaaaaaa gatttcgtca acaggtataa agccatctat gagcaggccg 423661 gcgtaaaaaa tttgaaagtc actgcgggag aagtagataa ggacgatcaa gacaacaaga 423721 cgatgaaaca tatcccgtat aaagtcagca tgaacacaaa tgccggcaaa gtcagcttca 423781 agaatactgc tgtgctgaaa ttagaaaaaa cagatgacga ggagtcatgg aatatagatt 423841 gggacccatc gtttattttc aagcagctgg ctgacgacaa aaccgtgcaa attatgagca 423901 ttgaaccgaa acgaggccaa atttacgata aaaatggaaa aggcttagcc gtcaatacag 423961 atgttccgga aattggaatt gttcccggag agcttggcga taaaaaagag aaagtcataa 424021 aagaactcgc caaaaaactt gatttgactg aagacgacat caagaaaaag ctggatcaag 424081 gctgggtaaa agacgattcg tttgtgccgc tcaaaaaggt caagcctgac caggagaaat 424141 tagtttctga agcgacgtca ttacaaggcg taacaagaac gaatgtcagc tcccgctact 424201 atccgtatgg cgaaaagaca gcccatttga caggctatgt ccgcgccatt acagcggaag 424261 aactgaagaa aaagaaagaa ggaacgtaca gcgatacgtc taacatcggt atcgccggac 424321 ttgaaaatgt gtatgaagac aagctaagag gcacaactgg ctggaaaatc tacgtgccgc 424381 aaaccgggga agtcatcgct gaaaagaaag caaaggacgg cgaggatctt cacctcacaa 424441 ttgatatcaa aacgcaaatg aagctgtatg atgaactgaa ggatgacagc ggggcggcag 424501 tcgcgctgca gccgaagaca ggcgaaacac tcgcccttgt cagcgcgcct tcctacgatc 424561 caaacggatt tattttcggc tggagcgata aggaatggaa aaagctaaac aaagataaaa 424621 acaatccgtt ttcagcgaaa ttcaataaga catacgcgcc aggttctacc attaaaccga 424681 ttgcggctgc tattggaatc aaaaacggca cccttaaagc cgatgagaag aaaacaatca 424741 aaggcaagga gtggcaaaaa gattcaagct ggggcggcta ttcagtgaca cgtgtgtctg 424801 agagacttca acaagtcgat ttggaaaacg cccttattac gtcagacaat atttattttg 424861 cccagaatgc gcttgatatg ggagcggaca cctttacaaa aggcttgaag acattcggtt 424921 tttcagagga cgttccgtac gaattcccga tccagaaatc gtctattgca aatgacaagc 424981 ttgattcaga cattttgctt gcggatacag gctacggaca agggcaaatg caaatgtctc 425041 cgcttcactt ggcaactgct tacacgccat ttgttgacaa tggagacctt gtcaaaccga 425101 cgctgatcaa aaaagattca caaacagctg atgtttggca caagcaagtg gtcacgaagg 425161 aaggagcggc agacattaca aaaggtctga aaggcgttgt ggaagatgag cgcggatcag 425221 cgtatcagcc tgtcgtgaaa ggaatcacag tggctggaaa aacaggaaca gccgagctga 425281 aaacatcaaa agatgataaa gacggcacgg aaaatggctg gtttgtcggc tacgattacg 425341 aaaacaaaga cctgcttgtc gccatgatga tccaaaatgt gcaggaccgc ggcggcagcc 425401 actatgtcgt tgagaaagcg aaaaagcaat ttcaatcgaa ttaaaatgtc tttttaaaag 425461 gagcgaaagg aaaaagggga tctgaggccg aatgaactag taagggggca aaacccggtt 425521 tatacaaaga aaagagggat tttgcatgca gcgtattcaa ttggcggagg atcttcaatt 425581 ttcaagagtc atacacgggc tttggcggct gaatgaatgg aactattcag atgctgaact 425641 tctaagcctc attgaatggt gtatcgatca cggcatcacg acctttgatc atgcggatat 425701 ttatggaggc tatacgtgcg aaaagctgtt tggaaacgcc cttgcccttt cgcctggatt 425761 aagagaaaac atagagttgg tcacaaaatg cggtatcgtt cttgaatcgc ctgaacggcc 425821 cgctcacaga tcgcatcatt ataacacaag caaatcgcat attttggcat ccgttgagca 425881 atcgcttatg aaccttagga cggattatat cgatatgctt ttgattcaca gaccggaccc 425941 gctcatggat ccggaggggg tagcagaggc gtttcaggcc ttgaaatgct ctggcaaggt 426001 caggtacttt ggcgtttcaa attttaaaga tcaccagtat cggatgctgg aatcatattt 426061 gcctgagaag ctcgtaacca accagattga gctttccgca tacgaattag aaaatatgct 426121 cgacggcact ttgaacctgt gccaggaaaa acggattccg ccgatggctt ggtcgcctct 426181 ggcaggcggc aaagtattca ctgaaaacac ggataaagac cgacgtgtcc gtacggcgct 426241 tgaatccgtc caaggggaaa tcggcgccgc ttcattggac gaggtgatgt acgcatggct 426301 gtatacgcat ccggccggca tcatgccgat tgtcggaagc ggaaagcgcg agcggatttc 426361 cgccgcgata aatgcgttgt catacaagct tgaccaggat caatggttcc gcatttttac 426421 agccgtacag ggttacgata ttccataaaa agcatcagtt taccagctga tgctttttca 426481 atattgtcac accgcttagt gccaaattac catttataag tgattgattc tttcttgaaa 426541 gcgttttata ttaaaaggaa acctctctat atcctctact gcatctcctt gcgacttcat 426601 ccgcacatca agattggcta ggaggtcttt tttatgtata tgactgccag agaacaaaag 426661 ctgttaaagc acttattatt acaaaacaga tatataaccg taactgagct tgctgagctg 426721 atgcaagtca gcacgagaac cattcacagg gaactcaaat caattaaacc gctgatggaa 426781 accgtggggc ttacgttaga taaacagccc ggtaaagggt tgaaagcagt gggaagtccc 426841 gagggtaaac aaaagctgct tactgattta tcatatgaac agcatgaata cagcgccgac 426901 gaacggaaac tgctcattct ttgttcgtta ttagagtctc aggagcccgt caaactgtac 426961 acgcttgctc atgatctcca ggtgacgaat gccacggtca gctatgactt agatgagctc 427021 gagaagtgga tttctccctt tggactgaca ctgatccgca aaagaggttt tggcatccag 427081 ctcatagggc cggagaatgc gaaacggaaa attgtcggca acttgattgt gaaccgtctc 427141 gacatccaaa tgtttttgga agcggttgaa ttaaacatca aaggaaaaac cgattcttca 427201 gagaaaatgt tcggggttgt cagcaaaggt gagctgttaa aaatggagcg catcttattt 427261 cagctcaaag aaaaaatcgc tttttcattg tccgacagct cctatatagc gctcgtcgtc 427321 catctgacgt atgcgatcga acgaattaag cttggggaaa ctatcaccat ggagcaaaat 427381 gagcttgagg aactgatgaa tgcgaaggaa tacagctccg ctcttgaaat cgcgggcgag 427441 cttgaacgtg ccttcggcgt gacgattcca gaggcggagg tcggctatat tacaatccat 427501 cttcgaagcg ccaatcgaaa atacaaaaca gaatacaaag cgcaggaaat tgagctggaa 427561 acagccctgc aaacaaagcg gctcattgct tttatttcag acaaaatcag aatggatctg 427621 acgaaaaact actctttata tgaaggcttg attgcccatt tggagccggc cgtcagccgc 427681 ataaaagaaa atattgagat atacaatccg atgaaggaac agatcaagcg cgattatttt 427741 ctgctttata tggcgatcga agaaggtgtc gaaaagtatt ttccgggcat gtccttttct 427801 gatgatgaaa tcgcttttat cgttcttcac tttggctcgg ctcttgaaat caaaaaagaa 427861 gaagcaaaag tgaaagcgct tgtcgtctgc tcaagcggga tcggctcctc gaaaatgctt 427921 gcctccagac tgaaaaaaga gctgccggaa attgaatcgt ttgatatgtc atctctgatc 427981 gagctaaagg ggaaggatgt tcaagcctat gatatgattg tgtccactgt accgattcct 428041 tatgaaaaca ttgattacat catggtcagc ccactattaa atgaggaaga cgcaaaccag 428101 gtcaagcagt atatcaagcg gaagattccc cttattctta acaaaaaaag aagctcgaag 428161 gaagaggcgc agcaagctga tgtacctgac atgctggagg cggcggaaag catagggcgg 428221 tatatggaag ttatccaaga tgttctgcgc cattttacgc tagctcaact caaaacaaac 428281 ccggaccata gcatgcttct gctagagctt tttcaacagc tgaagaagga tggcctgatc 428341 cgtgatccgg aaaaagccgc ggtttgcctg gctgagcggg agaaacaagg gggattggga 428401 atccccggaa caaacatggc gctttatcat ctcaaaaatg atgaaatcgt cctgcctttt 428461 ttcaaaatgt ttgatctcag caccccctat gaagtggatg gcatggacgg aaataccctc 428521 aggatgacac gcattctcgt catgatggcg cctggctcat tatctgctga aggctcggag 428581 attttaagcg cgatcagctc ggcaattatc gagagcggag aaagcatggc ggggtttcag 428641 gaagaaggag gacaagaatt gtatcagcgg ttaaaccgca tatttttcac atggatgaaa 428701 gaaaaaaaca tactgtaaac ctgcatggca cacgtcaaaa atttggcgtg tgtttttctg 428761 tggatgggga acaaaataag aaaatgtggg actattttat cattcagtat tggaataatt 428821 ccaaaatgaa atagttttac aagttatctt ttttgggtta aaatgggtga ggtaaggaag 428881 aaaatctaac aaattattga agattcaaga gaatatagga gatgacgata tggaaacatt 428941 acagcatctg attctgcatg acatgccgaa tagcgaagaa atagaggctg taaaaagcgg 429001 agaccataca ctgacatata aaggttaccg taaacggatt aatcagctgg cgaatgccat 429061 gcttcaaaaa ggaattcaaa agggcgaccg tgttgcattg ctttgcaaaa acggccatcc 429121 cgcctcaact gttatgttcg ccgcacttga aataggtgct gttgtcgtac ctgtcagctg 429181 gcagctgaaa ccatatgaaa tgacaggcat tttaaaagca agtgaaccaa aagcgatgtt 429241 ttacggagcg gagtttaaag agatactgga tgaagttctt cctgaattgt cctcactgtg 429301 tgtaacaatg gaaacaggaa cagcttacga aacatctgct gaatttgaag cgctgtttgc 429361 aggtcctgat catttgccag agacggaaat ggtttcacct gatgatacag cacttctgat 429421 gtttacatct ggaacaacgg gaaacccgaa aagatgcatg attacacatg gcggcatata 429481 cagatacgtt aaaaaatcca acagctcaat agcacgtatg aagggccttc gttttctcgc 429541 gtgccatccg atttatcata cgagtgcgct catttgcatc atgcttggaa cgtttgcaga 429601 aacaacattt gtgtttacaa aggatcaaga tcctgttcac atgctgaagg tcattgaaga 429661 agagaagatt cagaccgtga tggctcttcc tgtgttctac acgtatttgc ttgaggcgtg 429721 ggaaaagcac caaactgact tatcttcgct tgttatttta atgacaggcg gaacaaaagt 429781 gccgagcagc ctaataagcc gctatcttga tattggcatt ccgcttgcgc atggctatgg 429841 aagtactgag gcttggggca tcagcacatg gacgcctgat atgggaatgg ataaagcggc 429901 atctgcagga aaacctgtgg caggtgttaa agtcaaagtg gaagatcctc tgaccggaga 429961 agaacttcct caaggagaaa tcggcgaaat cgttgttcat actccattct tatttaaagg 430021 ctatgaagac aatcctgaag caacagcgaa agtgctgcaa aatggatggt ttagaaccgg 430081 agattcagga tatgtagatg aagatggctt tattttcatc acgggacgct acaaggatgt 430141 cattatttac ggaggcgata acgtctatcc tgatcaggtt gaagaagtta tccagcagat 430201 cccgggaatc cttgaaacgg ctgtggtcgg tattcctgac ccgctttacg gtgaaaaacc 430261 gaaagctttt atcgtgaaaa atggcggcca gcgcatcacg gaagaggatg tcatcgcatt 430321 ttgtaaagaa cgcctgtccg cttacaaaat acctgaagtt gaatttgtta acgaactgcc 430381 gaaaaacaac cttggcaagg tgaaaaaaga cgtcctgcgc aatcaggctg tacattcata 430441 aaagaagaag cccgtccact ttatgtggcg ggcttctttg cagttgcaca gacggaaagc 430501 tcaggcttaa tgttcttaaa ttgtatatca atgtcttcga agccggctgc tttaaagtca 430561 gcaatcatct gtcttccaaa tgatttggtt ttctcaggac tggcatccgc ttcccgcggc 430621 tgcatcgtaa tggctgcttt gccgcctggc tttaatgccc gataaatctg ttttatgcct 430681 tttgtttggt cattccaaat ggtgtagttg ttaacggaaa tcactttatc ataaaacgag 430741 gcggggagag gaaatgtctc gatgcttcct tgtatcaggc gtacgccctt tggtttcact 430801 ctgcgggcgg ccagcttcag catggcctct gatacatcaa tcccatgaag atgaacatcc 430861 ttctcgcgtt tcagcatctg ctgcatgcag tatcccgggc caaacccgac ttctaaaatg 430921 ctgtccccgc gcgtgatacc cagctgattg attgtccact gattcagtgt ttgattttca 430981 gcagccatga tgtacccggc aatcatgccg atgacgccct ttggcctgct gaatcttcta 431041 gaaagcatgt taatcattca gcaaccaacc ccctttttga gttaatttcc tctcagcgtt 431101 ccatgtgaaa catttttctg ataaagcaat gcgaaggtgc caagccatgt ttatccaaag 431161 agtgtgtgag gtacacaaca aatagacatg aaaacaaagg aggagaatca tcatggcaaa 431221 ttatccaaaa gaactgccgg cacaaactca aagtcgccag ccgggaattg aaagcgaaat 431281 gaatccaagt ccggtgtatg agtacgagga ttataaagga gcagacaaat taaaaggaaa 431341 agtagctctt attacaggcg gcgacagcgg gatcggacgc gcggtttccg tcgcttacgc 431401 aaaggaaggc gcagacatcg ccattgtgta taaggatgag catgaagacg ctgaggagac 431461 gaagaaacgt gttgaacaag aaggcgtaaa atgcctgctg attgctggtg acgtaggtga 431521 agaggaattc tgcaatgaag cggttgaaaa aacggtcaag gaactaggcg gccttgacat 431581 ccttgtcaac aatgcaggtg aacagcaccc gaaggaaagc atcaaagata ttacgagcga 431641 acagcttcac cgcacattca aaacaaattt ttattctcaa ttttatttga ctaaaaaagc 431701 aattgattac ctgaaaccgg gcagcgccat catcaatacg acatccatca acccgtacgt 431761 agggaacccg acactgattg attatacagc gacaaaaggg gcgatcaatg cctttacaag 431821 aacaatggcg caggcgcttg tcaaagacgg catccgtgta aatgcagtcg cgccgggtcc 431881 aatttggacg ccactaatcc cagctacgtt ccctgaagaa acagttgctc aatttgggca 431941 agatacgccg atgggccgtc ctggacagcc tgttgagcac gtcggctgtt atgtgcttct 432001 ggcatcagat gagtcctctt acatgacagg tcagaccctg catgtcaacg gcggaaactt 432061 tgtgacgaca taagagggag tgagacatat gggcatcacg aaagaagaag tgaacagcta 432121 ctatcaaaaa gcagggattg tattaacgga cgaggaagta gaccaaatcc agctgatgga 432181 ttacggctta ggaaaagaaa gaaaagtcgg gctccagctc ttcgtctacg tcaatacaga 432241 ccgttattgt tcaaaggaat tggtgctgtt tccgggacag acttgcccgg aacaccgcca 432301 tccaccggtc gacggccagg aaggcaagca ggagaccttc cgctgccgct acggaaaagt 432361 gtatctttac gtagaaggag aaaaaacgcc gcttccaaaa gttctccctc ctcaggaaga 432421 cagagaacac tatacggtct ggcacgaaat tgagctagaa ccgggcgggc aatacacgat 432481 tccaccaaac acaaagcatt ggttccaggc cggggaagaa ggtgccgtcg tgacggaaat 432541 gtcatcgacg agcacggata aacatgatat ctttaccgat ccaagaatat aaggatgggc 432601 ttaacagccc atcctttttg tattgaaaaa aacagaatca tcgctataat gggtaaaaaa 432661 ggaaagaggg cgaggcaatg ttcacttgca aggtaaatga gcacatcacc atccgattat 432721 tggagccgaa ggatgcggag cggctggccg aactcattat ccaaaatcag cagcggcttg 432781 gcaagtggct gttttttgcg gaaaatccaa gcagcgctga cacgtaccga gaaacaatca 432841 ttccagattg gcggcgccag tatgccgacc tgaacggcat tgaggcgggt ctcctttatg 432901 acggcagcct atgcggcatg atcagcctgc ataaccttga tcaagtgaat cgtaaggcgg 432961 aaatcggata ttggattgcc aaagaatttg aagggaaagg cattattaca gctgcctgcc 433021 gaaaactcat tacgtatgct tttgaagagc ttgagctgaa tcgtgtggcg atctgtgcgg 433081 ctgtcggaaa cgaaaaaagc agagcggttc cggagcggat cgggtttcta gaggaaggaa 433141 aggcacggga tggcttatac gtaaacggca tgcatcacga cctcgtctac tacagtctgt 433201 taaagcgtga atgggaaggc gaaaaataaa gagcacactt tcttgtttaa atcttccccg 433261 gatgtggaaa agtaacagcg gagacgttaa aaaggagtga ttcgagatga atcagcaaga 433321 cattaaacaa aaagtgcttg atgttctaga tcaccataaa gtaggttcgc tcgcaacagt 433381 tcaaaagggc aaaccgcatt cccgctacat gacttttttc catgacgggc tgacgattta 433441 cacaccgaca agcaaggaaa ctcataaagc ggaagaaatt gagaacaacc ccaatgtcca 433501 cattttatta ggctatgatt gtgaaggttt tggcgacgca tatgtcgaag ttgccggaaa 433561 agcaaagatc aacaattcgg cagaactcaa ggacaaaata tggagttcca aattagagcg 433621 ctggtttgac ggcaaggatg atccgaatct ggtgattctt gaaattgaac cggaggatat 433681 cagattaatg aatgccgggg agaaaacacc ggtctcactc gaactataaa aaatttgtgt 433741 tttcaggggc gatatgttat tatgaatagc tagtaagaaa aataagcaaa taaaaaagaa 433801 agtaaacttc ttttttctgt tttgagagag aagcttaccg cttcccaagc agcataacca 433861 gctgccctta ttcttttcct tcataacaaa tcgcccctaa cgatgagatg gaaaaaagac 433921 ttttttgttt tacaattcac accggcgcgg cttcggagcc gcagtgacga ttgagaggta 433981 gggctttcgt tgtcttgtgt tcaagaaatt tccatggtgt ttactttcca gaatgattct 434041 tcggaacaat gctttatgaa tctaacccgc ctgacttggc ggatgatata atctttattt 434101 gcgtatagaa aagaataaga caaaccgccc ggcgtacgcc ggacggtttt tttattgcaa 434161 aaaacacatc gtactgaaac ctccttgtct tctttccagt cttatctcta ggatgaaatt 434221 ggaggaagaa taacgtgcat gtcattacaa cacaagtact ttttattttt tgttttttat 434281 tgctgattca ctcgatagaa accttagcct atgcgacaag gctttccgga gctcgcgttg 434341 gatttattgc gtccgcgctt tctctgttta atgtcatggt catcgtatcc agaatgtcga 434401 atatggtgca gcagcccttt actgggcatt taattgatga tgctggaaaa aacgcactgg 434461 cgattgtagg ggagcagttc cgctttttaa ttttcggatc gacagtcggc accattttgg 434521 gcattatcct gctcccgtct tttgtcgctc ttttttcacg ggcgattatt cacttggcgg 434581 gcggcggcgg ctccgttttt caagtattcc gaaagggatt ctcgaaacaa ggattcaaaa 434641 atgccctttc ctatttgcgt ctgccgtcca tttcatatgt aaaaggattt catatgcgct 434701 tgattccgaa gcgtttgttt gtcatcaaca tgctgatcac atcgatttat acgattggtg 434761 tgctttcggc tttatacgca ggccttttgg cgccggagcg cagcacgaca gccgtcatgg 434821 cttcgggttt gatcaacgga attgcaacga tgctgctggc tatttttgtt gatcctaagg 434881 tatccgttct tgctgatgat gtggcaaaag gaaaacgaag ctatatctat ttaaaatgga 434941 cctctgtcac aatggtcaca tcaagggtgg cgggcacact cctcgcccag ctcatgttta 435001 ttcccggggc ctactatatc gcgtggctga caaagtggtt ttaataagaa aggctggatc 435061 ataaagatcc agcctttttg cgcttcctta tttatagttc cttaatccgc ggtcgtacaa 435121 aaaatttccg aatgggacga aagcggcgat gaagccggca gctgaccatt tcagcggcca 435181 tttgacagag aaggttgcat aagccaagac aagcaaatac aaaatgaaca acccgccgtg 435241 aaccgaaccg acaattgtca ccgcaagcgg aaggcctgcc caatatttaa gcggcatagc 435301 gatgaacaac aggattaaga gtgacattcc ttcaataaaa cccatcgtgc gaagtcttcc 435361 gatcggcgtg tgcagcataa atcgccctcc ttgtggacac gttttcattt tatactataa 435421 acaatccggg ggggcatatg acagctttca aaaaatgttc ggaaaacatt catttttaca 435481 tgccttttct agggaactgt acttgtcatt tacaaaaata cccgagataa tgtgtacaaa 435541 atcaaaaaag aaggatgttg aaatgaaact tgaccagatt gatctgaata tcattgagga 435601 gctgaagaag gacagccgtt tgtcgatgag ggaattaggc agaaaaatta agctgtcgcc 435661 tccatctgta acagaacggg taagacagct tgaatcgttt ggcatcatca agcaatacac 435721 gctggaggtc gaccagaaaa aactggggct tcccgtttcc tgcattgtgg aagcaaccgt 435781 taaaaacgcg gattatgagc ggttcaaaag ctatattcaa acattgccga atattgaatt 435841 ttgctaccgg attgcgggtg cagcctgcta tatgctgaaa atcaatgccg aaagcctcga 435901 agcggtagaa gatttcatta acaaaacatc gccctacgcg caaaccgtca ctcacgtcat 435961 tttctcagaa attgacacga aaaacgggcg cggttagaga gtgccgcgcg aagtctgtta 436021 taataacagg atgagcgtga aagaaagaga agtgatcaag catgtcaaaa acagttgtat 436081 tagctgaaaa accttcagtc ggccgggatt tagcccgggt actgaagtgc cataaaaaag 436141 gaaacggtta tctcgaaggc gatcaatata ttgtgacttg ggctttaggc catttggtga 436201 cgcttgctga tccggaaggc tacggaaaag aatttcaatc atggcgccta gaggatctgc 436261 cgattatccc agaacccttg aagcttgtgg tgataaaaaa aaccggaaag cagttcaatg 436321 cagtcaaatc ccagcttacc cgtaaagacg tcaatcagat tgtcatcgcg actgacgcag 436381 gccgggaagg tgagcttgtt gcgcgctgga tcattgagaa agcgaatgtc cgaaaaccaa 436441 tcaagcggct gtggatttca tctgtgacgg ataaagcgat caaggaaggt tttcaaaagc 436501 tgcgcagcgg caaagaatat gaaaacctgt accattctgc cgtcgccaga gcggaagcgg 436561 attggattgt ggggatcaac gccacccgtg cacttaccac aaaattcaat gcccagctct 436621 catgcgggcg tgtgcagact ccgacgcttg ccatgattgc aaagcgcgag gcagacattc 436681 aggcgtttac gcccgttccg tattacggca tacgtgctgc agtcgacggc atgacgctga 436741 cgtggcagga taagaaatca aagcagacga gaacgttcaa tcaagatgta acaagccgtt 436801 tgctaaaaaa tctccaagga aagcaagcgg tcgtagctga gctgaaaaaa acagcgaaaa 436861 aaagctttgc gcctgcgctt tatgatttaa cggagctcca gcgtgacgcc cacaagcgct 436921 tcggtttttc tgccaaagaa acgctttctg tcctgcagaa gctatatgag cagcataagc 436981 tcgtcacata tccgcggacg gactctagat ttttatccag tgacatcgtc ccgacgttaa 437041 aagaccgtct ggaaggcatg gaagtaaaac cgtatgccca atatgtcagc caaattaaaa 437101 aacgcggcat taaatctcat aaaggatatg tcaatgacgc gaaggtgtca gaccaccacg 437161 cgattatccc gaccgaagag ccgctcgttc tcagcagtct gagtgataaa gaacgaaagc 437221 tgtatgacct gattgcgaaa cgtttcctgg ctgtattaat gcctgcattc gaatatgagg 437281 aaacaaaggt catcgcagaa atcggcggag aaacctttac ggcgaaaggc aaaaccgtgc 437341 agtcgcaagg gtggaaagcc gtttatgata tggcggaaga ggatgatgag caggaggatg 437401 acagagatca gacacttcct gcgcttcaaa aaggcgacac acttgccgtc cgcacgttaa 437461 cggaaacaag cggccaaacg aagccgcctg cccgctttaa tgaagggacc ttgctgtcag 437521 cgatggaaaa cccaagcgcg tttatgcagg gagaagaaaa aggcctcgtc aaaacgcttg 437581 gagaaacagg cggcctcggc acggtggcaa cgcgtgccga cattattgaa aaactgttca 437641 acagcttttt aatcgagaaa aaaggccaag atatttttat cacatctaaa ggaaaacagc 437701 tcctgcagct tgttccggag gatctgaaat caccggcctt aacagcagaa tgggagcaaa 437761 agctgtctgc gatcgcggcc ggcaaattga aatcggctgt ttttattaaa gatatgaagg 437821 cttacgctca ccaaacggta aaagaaatca aaaacagcag ccaaaccttc cgacatgaca 437881 acattacggg aacggcatgt ccggaatgcg gcaaaatgat gctgaaagta aacggcaaac 437941 gcgggacgat gctcgtgtgc caagatcgtg aatgcggaag cagaaaaacg attgcccgaa 438001 aaacaaacgc acgctgccca aattgccata aaagaatgga gcttcgcggc caaggcgagg 438061 gccaaacctt tgcgtgtgtg tgcggtcacc gtgaaaagct ctctgtattt gaaaaacgaa 438121 aaaacaaaga caaagcgcgt gctaccaaac gggacgtatc ctcttatatg aaaaaacaaa 438181 ataaagatga gccgattaac aacgcgctgg cagaacagct gaaaaaactc ggtttggata 438241 aataataaaa aaacctgtgc ctatcgcaca ggttttttat tggacttagg tcctgttttc 438301 ttaatgttca aaaagggaaa aaaaagctag caatctgcat tttttttctt ttatagtaaa 438361 tgtactttgt aacatggcag tcatattttc gtctataact atttgtgagc gtctgatttg 438421 cttcaggcga caaaggggga tttgcctgtg aggcatgtac taattgctgt catcttattc 438481 ttcttatcta tcggactttc cgcagggtgt gctgaagctg gaaacaagac ccaaaatcag 438541 tcggcgacag aagtgaatgc cagcccgctc cagccggcgg aatatttcat ctatcacaat 438601 ttaatgaatg acaaagggct gatcaaaacc gatttttcag accagccttc ttacttgtcg 438661 gaatctctcg gactgtggat ggagtttctg ctcagcaaaa atgacgcacc acatttccag 438721 gatcaatatc agcatctgac tgattcattt ctgatgagca atcacttggt gacgtggaag 438781 attcaaaatg gccaagcgag cgggacgaat gcgctgatag atgatatgag aattatgctg 438841 tctcttgacc aagccgccgc aaaatggggc cgcagcgact acgcgcaaac ggctagggat 438901 atcggcacgt ctttgaagac atacaatatg aacaacgggt tttttacaga cttttacgac 438961 tcacaggccg cttcaaagga tgtgacgctt tcatacgtca tgcctgatgc cttagctgtc 439021 ttaaagaaga atggaatcat agacgaagaa acagaacagc ggaatgccaa tgttctctat 439081 tcagctcctt taaaaaatgg ctttctgccg aagacataca gctcggagac gaaggaatac 439141 acatatgata gtgaaatcaa cctgattgat cagctttacg ctgcttggca tttgccggaa 439201 ggggatgaaa aagcatctgt tttagcggac tggatcaagc aggaatttca gaaaaacgga 439261 aagctgtacg ggcggtattc ggcatatacg aaggagcctg ccgtccaata tgagtctcca 439321 tccgtatatg ccttagccgt attgtttttg acaaaacagc atgaaaacag ttctgtcatc 439381 aaagccatat atgatagaat gaatgacttt gaaattcatg atccggtgaa atcgtattat 439441 ggaggctata tgagcggcac tcagacgcat tcatttgaca atctgctgcc gctgttagcc 439501 gaaaggaagc tttttaatga aaatatcatt cagtgaatca caaaaattat ttgcttattt 439561 ttcagggctc atcgcggccc tgtctttgtt tatttattat gtgtcagccc agcaatcaga 439621 aggtgctctg atcctttgca tcacatttgg cgtcatcgcc gcaggcatct ggttcggccc 439681 gatttacgcg ctggcagtga ccttaatcgt actctttgtt ctcggcacct taatgatgtt 439741 tttccagact ggacagacat cgctctttcc ggctgaggaa gggctgcgaa tgcttgtcgt 439801 gtggggaatc gcgcttttgc tgttttcttt tatttctgga agaatccacg atattacagc 439861 agagcttcgg cgctcaatga cacggcttca atccgaaatt aaaagctatg ttgctgttga 439921 cagagtgact ggttttgata acaagcaaag gatgaagctg gaactttcag aagaaatcaa 439981 gcgggcggag cgctacggca attcttttgt gtttttgctg ctccatatgc attatttcaa 440041 agagtttaag tctttgtacg gtgaaaaaga aacggaccgc ctcttccaat atgtcggtca 440101 gcaaatcagg acaagcgttc gggaaacgga taagaaattc cgtccctctg acgagcgtat 440161 cgggatcgtg ctgacgcaca cgcctgctga acatatgccg gccgttctga ctaagctgaa 440221 gaaacaattg gatacatatc agctggaaaa tggaaagtat gtgtcgctta cgttccacgt 440281 ttgctatttg ccctaccgca acgatatcca aacagctgat caatttttag aagaactgga 440341 aaacgagatg atgatgaatg aactataaag gaatcacatt gctatgcgtc atgatgcttc 440401 tattttcagc tattgcgtct tttcccgttt ctgcgcaagc gaaagatcag gatgccggca 440461 ttctcatcat ctactcaacc ttggacggca aagagtcgtc acaagtcaaa atgctcgatt 440521 tgcttgcggg ccactttaca tcccatgtga cagtcaaaaa agattcagac gttgaagcgt 440581 cggatttcaa agggaaagac catgtgattt attacggcca aacgaaaaga aagctcagcc 440641 aaaaattgct gtctcttatc agcggcgtga aaaaaccggt tgtcgccatt ggctataacg 440701 caggccaaat cagccaattt tctgggcttt cattagcccg caaagaaaat gtgtttcagg 440761 ttcacagcag gtcagaaaag gccgatgtgt ctctggaaag cgggcttaac gtgctgagtg 440821 tatcaggcct gaaaggaacg gcgctttaca ccttcaaagc ggatgaaggc acaacgcatt 440881 cttttatatg gaaaacaaaa aaagggaatg tgtacattgg attaacaaat ttgttaaatg 440941 acaatttgat cgtggcgaaa cagctcagag aagctttcgg agagaaggcg gggacgacgt 441001 tattgtattt gcgtctcgag gatatcagcc cgatgtctga tgaaaaactg ctgcttcaag 441061 ccggtacata cctgcataag cggcatattc cttttatcct ggcggtcatt ccggtttact 441121 tgaatccgga aacaggcgac aaagtgtatt tgtctaatca accgaagatg gtcaaggtgc 441181 tgaagaagct gcaaagcatg ggcggcagta tcatagttca cggctatact cacgcttatc 441241 gctacagtga aacaggagag ggatttgaat tttgggatgc aaaggcggat cagccgatta 441301 catccggaaa tgccgaagac cccccgtcca ttttggagaa agaacaggac ttcccgaacg 441361 aacaagccta tcacagctat cttgaaccat ttcgggaaaa ggaagaaacg tatacaaaac 441421 aaaaactgac gcgtgccatt gaggatttga catcatcggg tctttacccg ctggcgtttg 441481 aagcgccgca ttacacgatg tccgaatatg gctatcaaat cgcctcgcag tattttacaa 441541 gcattttcgg ccaggtccag ctcagcagca caacatggaa aacatccggt gcacctccgt 441601 ttgtgactgc tccttcgatg ctgcacggaa tgacgcttta tccggaaacg atcggctttg 441661 tcgacacatc gaagcaaaac ccgctcggtg agatggagga gcatatctcc cagatgattg 441721 attttgaagg cggagtagcc ggaggatttt atcacccgta ccttgggatg aaatatctgc 441781 ctgagctggt tgatcagatg gaacgcattc cagacagtga atggcttgat ttaaagaaaa 441841 cgaaacaaac cgtcaaaaca gacaaagtgg aaattcatac aagcggtgac ggaacgattc 441901 aggtgaaaaa cggcgtaagc cccatttacg agtttttcga tcatcaccgg caaacccctc 441961 tggaaaaggc gttatggatt ctctccgctg ttgtgctctt atttgtcatc atgtttgtca 442021 gttatacgtt ttacttgaga gccacattga aaaaacgaat ttttaaggag agaagaagcc 442081 ttgggtaata cgctgttctt tatctcgcta agtttaatat gggttatgct tctctaccac 442141 atgttcctca tgcagggcgg gtttcgccac tatatgacct tcgaacggaa tatcccgaag 442201 tggagagaaa atatgaagga actgccgaag gtcagcgtcc tcatcccggc gcataacgaa 442261 gaggttgtga ttcggcagac gctgaaggcc atggtcaacc tttattatcc gaaggaccgg 442321 ctggagatta tcgtcgttaa tgataattca tcagaccgga cgggtgatat cgtcaatgaa 442381 ttttccgaga aatacgattt catcaaaatg gtgattacga agccgccaaa tgcaggaaaa 442441 ggaaaatcct ctgcacttaa ctcgggtttt gccgaatcga acggcgatgt gatctgtgtg 442501 tatgacgccg acaacacgcc tgagaaaatg gccgtgtatt acctcgtgct cggcctgatg 442561 aatgacgaaa aggcaggcgc cgtggtaggg aaattccgcg tcatcaatgc ggcaaagacg 442621 ctgctgacga ggtttattaa tatcgaaacg atctgttttc agtggatggc ccagggaggc 442681 agatggaagt ggttcaaaat cgccacgatc ccaggcacca acttcgcgat ccgcagaagc 442741 attatcgaaa agctcggagg ctgggatgac aaagcgctcg ctgaggatac tgagctgacc 442801 atccgggtat ataatctcgg ctatcacatc cgctttttcc ctgccgccat cacgtgggag 442861 caggaaccgg aaacatggaa ggtatggtgg cgccagcgca cccgatgggc gcgcggcaat 442921 caatatgtcg tgctcaaatt tttggcgcag ttttttaagc tgaaacgaaa acggattatc 442981 tttgatttgt tttatttttt ctttacgtac ttcctgtttt tctttggcgt gatcatgtca 443041 aatgcgattt ttgtagtgaa tttgttttat gatttgcatt tgtctgttgg atttttggca 443101 atgattctct ggattttggc gtttttctta tttatgacag aggtcatgat tacgttgagc 443161 attgaaaaaa cagaaatgaa caagcaaaac ttttttatcg tatttctcat gtacttcaca 443221 tactcgcagg catggattgt gcttgttatc tactctttat tcgtagaaat caagcaccgt 443281 ttattcaagc aagaggtcaa atggtacaag acagaacgat acaatcaaca taaaagcggg 443341 tgaccttttt gaaacaaata atgatttttc tcacaagctt catgctgctg gcgatgactg 443401 gacaaacggc tcttgccaaa gacgtacagg tcagcggttc gctccttggg aaaagcagcc 443461 aagaacaagc caaacagcag gtgctgacaa gcgagctgat tacactgtat ggatcaaaag 443521 acagcgcaga gctgacgtat cagatcccgg caggcgcctc ttcgggcaat cagcaattgg 443581 taatcgaata cgaggcatca aatcttttaa tttctccatc atcgttaacg gttgtcattg 443641 atgatgaacc ggtcaagacg ttaaagcttg atggtgattc caaacggaaa acagtgaagc 443701 tgaatctgaa taaaagccag tctgcgcaag gctatcacaa cgtatcgctg aaattctacg 443761 gcgtaatgaa agagggcgtg tgcgtcagac aggatacatc aggcaactgg atcaaaattt 443821 atccggacag ccggctgaca cttgctgaca gcagtgaagc gaagggaacg tcgctggacc 443881 attatccgta tcctttcgcc caatctggaa atacagcgga agaaacagct atcgtcattc 443941 cggataaccc aagttcagca gaaatagaag ctgctgttaa aacagaaggc tatttgaaaa 444001 cggtggacag cagtgtcagt attgcgtatg tcacggaatc tgaactgaaa aaaatcgata 444061 agccgacgat tgttatcggc gtggacaagc attggaacgg caaagtgaaa aaactgttga 444121 aacaagccgg gctacaggca aaaggagaaa accttctgct tgcggagcgg gtgctgaaag 444181 cagagggcaa acagcagccg gttctgtttg cgcaagcggc gtccgaggac gcgctcacaa 444241 aaaaaatcag cgtgatgaca gatcagacat atacaggcca gctcagcggc gatacacttt 444301 caatcagcaa gcttcagcag actgaaaaaa aagaaagcga taagctgacc cttgagaatt 444361 ttggagcggg tgatatcaca attggagccg acaaaacatc ttcagcacat tatttttatc 444421 cggcttcggc tgttttagat gaaaaccaat cggcgaagct gtcgcttaaa ctgaaaaagt 444481 ctgaaacgat tcaagcctca acggctgaaa acgagtcagc ctctcaggct gcagaactga 444541 aagtgatgat caacggccag ccgcactcgg tccggcttga tgaattagga aaagaagata 444601 aaaacggatt ctatcatgtc acagtgaaag tggaccctaa gctgctgcaa aaaaaccgct 444661 acattgatat tcagttcgtc acgaccggtt taaaggaaaa caacccttgt aacaccactg 444721 atgaagaaaa gtgggttttt atcgataaaa acagtacatt atcatacgcc atcaaaggca 444781 tgtccccgtc agcggatttt caagagtggc cgctgcctta cgccggaaac caggatcaaa 444841 caacgttaat cgtgcttcct gacaccgtaa gccaatcgaa gctagaggag ctttctctcg 444901 taacagaatc ctttggcaac gaagcacagc attcatatac ggtaaagaaa tcatctgacg 444961 ttacagcaaa tgatgcgaaa ggacgaaacc tcattttcat aggagggatc aatcaatttt 445021 ctcttctgaa ggagaaatca tcagatctgc ttgtgccgca ggaaaagaac ggctcgtttg 445081 atgtatctag tttcgagatg ctgaatgaga cgacaaaaca agtggtattt acccaagcat 445141 cggtttggga ttcacgctat acaatggctg tctttgcacc gtcaaaagga gatggcacgg 445201 ctgtcacaaa agagatcatc agttatctga acagcaacga tgagtcggca accgtcctta 445261 atgaaacaaa cagccagcag gtgtttacaa accaccagca gctcaaatcg gaaacaaaca 445321 gttccgatgc agaacaacca acacaggatc atagccagaa atggatgtat attggtgtgc 445381 tggcactcat tatggtggtt gcggcagtgt tcatttggat tgccgtaaga cgcaaaaaaa 445441 gaaagacaga tacagaataa aacagaggcg attttagcct ctgttttttt atttttggta 445501 agtaaattcc atttgtggaa cctgtcattt tatttttttc tctcagccaa taagcctctt 445561 tacaacgtgc gggaacggga gtatgatctc ttttagaaaa caaatcgctt aatctgaaat 445621 cagagcgggg gacccaatag aacggctttt tgccgttggg gtgaatcctt tttaggtagg 445681 gctaactctc atatgcccga atccgtcagc taacctcgta agcgttcgtg agaggagatg 445741 aatgaaacct gtgttcgatg ttatggcaca ggggcatccg tttgcctctg tgttttttgt 445801 tgttcatttt tgaatgcaaa tcgcatacag agacatcata gcagaaagga ctatcatcaa 445861 catgtgagag caagacactg atggatgttt tattgtttta attgaaaaat gagaaattaa 445921 aaggggaaga catcgatgta tcattcaatc aaacgttttt tgattgggaa accactaaaa 445981 tcccaagcag ctggagagca aaaactgacg aaattaaaag ccttggctat gctttcctca 446041 gatgcgctgt catctgtcgc atatgggaca gaacaaattc taatcatttt ggcaacaatc 446101 agtgcagccg cattttggta ctccattccg attgcggttg gcgttctcat cttgctgctc 446161 gcactgattc tttcatacag gcaaattatt tacgcttatc cgcagggcgg cggggcgtat 446221 atcgtttcta aagaaaatct cggtgaaaaa ccgggattga ttgcgggcgg ttcattgctt 446281 gttgattata ttttaacagt agcggtaagt atttccgcag gcacggatgc catcacgtca 446341 gcctttcctg cattgcatga ttatcatgtg ccgatcgcta tttttctcgt gttagtgatt 446401 atgattttga acctgcgcgg gctttcggaa tcagcatcca tacttgccta cccggtttat 446461 ctgtttgtgg tggcgctttt ggttctcatt gcagtcgggt tgtttaaact tatgacagga 446521 caaatagacc agccagccca tcatacatcg ctcggcacac ctgtagccgg cattacgcta 446581 tttttgctgc ttaaggcttt ttcctccgga tgctcagcgt tgaccggggt tgaggccatt 446641 tctaatgcga ttcctgcatt caaaaacccg cctgcgcgaa acgcggcaag aacgcttgcg 446701 atgatgggga ttttgctggc gattctgttt tccggcatca cggttctcgc gtacgggtat 446761 ggtacggcgc cgaaacctga tgaaacagtg gtttcacaaa ttgcgtccga aacctttggg 446821 cggaatgtgt tctactatgt catccaaggt gtcacatcgc ttattttggt tcttgcggca 446881 aatacgggat tctcagcctt cccgcagctt gccttcaacc tggcgagaga ccagtatatg 446941 ccgcgaatgt ttacagtcag gggcgaccgc ttaggcttct caaatgggat tatcttttta 447001 ggctttgcct ccattgttct cattatctta ttcgggggac agacggagca cttaatcccg 447061 ttatatgctg tgggcgtatt tattccattt acgctttcac aaaccggcat gtgcatgaaa 447121 tggatcaagc aaaaaccaaa aggctggatc ggaaaaatgc tgatcaactc ctgcggcgct 447181 ctgatatcat ttatggttct atccattctg tttgtgacga agtttaatgt cgtatggcct 447241 gtgttaatct ttatgcctat cgtcgttttg ctgttttttg cgattaaaaa tcactatact 447301 gcggttggtg aacagcttcg catcgtagac aaagagccgg aagaaatcaa aggcaccgtt 447361 gtgattgtgc ctgtggccgg tgtcaccacc gtcgtgcaaa aatcgattca ctatgcgaaa 447421 tcactgtccg atcaggtgat cgccgttcac gtgtcatttg acagagaaca ggaaaagaaa 447481 ttcgaaaaac gttgggaaga gcttaataac ggagtgcgtc tcgtgacgct tcactcctct 447541 tacagaagcc ttgtccatcc gtttgataag tttttggaaa cagttgaggc aaaagcgaag 447601 aaggagcagt tttccgttat ggtgctgttt ccgcaattta taacgaaaaa acgctggcac 447661 accatccttc acaaccaatc ggccttcctc ctcagagtcc ggctgttctg gaaaaaggac 447721 ataatggttg ccacactgcc gtatcatttt aaaaagtaaa gctctaggac caagggaatc 447781 accttggtcc tttttagcgg gaaaaggagg tatgggggtg tatacacaag gtgcttttgt 447841 gatcgtattg aacgaaagtc agcaaattct gctggtgaaa cgaaaagatg tccctctatg 447901 ggatttgccg ggcggcaggg ttgatcccgg ggaatcggct gaggaagcgg cagtgcggga 447961 gatattggaa gaaacgggat acaatgcagc gctttctgcg aaaataggtg tttaccaaag 448021 gccaaagttt caagatgaac agcatctgtt tttcggaagc attacaggcg gacaagcaat 448081 ggctgacggc acagagacag cgggattaaa gtgggtttcc ccggggcgtt tgccgctttt 448141 tatggtgccg aatcgaaaaa ggcagatcaa tgatttcaag aacggcgctc aagatgtaaa 448201 tgtcaccgtc aaggatagcg ggttgctcgc ggcgatcgac ctgttgaaaa gaagactggg 448261 caagtgattc aggtctccgg gttttaaagc ctttctcctg tggtattgaa aaaaggaaaa 448321 aggaggatac gttatggcac acaaaactgc aggacaagca atgacagagc tgcttgagca 448381 atggggagtt gatcatgtat acggcatccc cggagacagt ataaatgagt ttatcgaaga 448441 attaagacac gaaagaaatc aactgaagtt cattcaaacc cgccacgaag aggtagcggc 448501 actggcagcc gcggctgaag caaaactcac cggcaagatc ggagtctgtc tgtcaatcgc 448561 agggccggga gcggtgcact tattaaatgg tttatatgat gctaaagccg acggcgcccc 448621 tgtgctggcg attgcaggac aggtttcttc tggcgaagtc ggacgggact atttccagga 448681 gattaagctg gagcaaatgt ttgaggacgt ggccgtgttc aacagagagg tacatagcgc 448741 ggaatcactt ccggatctct taaatcaggc gatcaggacc gcctacagca aaaaaggcgt 448801 tgcggtattg agcgtgtcag atgatttgtt tgcggagaaa atcaaacggg agcccgtgta 448861 tacttcaccg gtgtatattg aagggaacct agaaccgaaa aaagaacagc tcgtcacctg 448921 cgcccaatat attaataacg ctaagaaacc gattatcctg gcagggcagg gaatgaaaaa 448981 ggcgaaacgg gagctcttag aatttgcgga caaagccgcc gctccgatcg ttgttacact 449041 cccggcaaag ggtgttgttc ccgataagca cccacatttt ctcggcaacc tcggtcagat 449101 cggaacaaag ccggcttacg aggcaatgga ggaatgtgat ttattaatca tgctcggaac 449161 gtcattcccg taccgtgatt atttgcctga tgacacgccg gcgatacagc tcgattcaga 449221 cccggcaaaa atcggaaaac ggtatccggt gacagcgggc cttgtctgtg attcggctct 449281 cggtttgcgc gaattgacag agtatattga acgcaaggaa gacagaagat tcctgaatgc 449341 ctgcacagaa catatgcagc attggtggaa cgaaattgaa aaagatgaga cagaggcaac 449401 aacaccgctt aaacctcagc aggtcgtggc ccgtcttcag gaagcggcag ccgatgatgc 449461 ggtgctctct gtagatgtcg gcactgtgac agtctggatg gcgcgtcatt tcaaaatgaa 449521 cgcgaatcag gatttcatcg tttccagctg gcttgcgaca atgggctgcg gcctgccggg 449581 agcgattgca gcgagcttgt ccgaaccgga acgccaggcg atcgccgtct gcggtgacgg 449641 gggattttcc atggtcatgc aggaccttcc gaccgccgtt aaatataagc tcccgatcac 449701 agtcgttatt ttaaacaacg aaaatctcgg catgattgag tacgagcagc aggtcaaagg 449761 caatatcgac tatgtcacaa aacttcaaaa tgtcgactat gccgcatttg cagaaagctg 449821 cggagcaaag ggcatcaaag tgaccaaagc ggaagagctt gcgccggctt ttcatgaggc 449881 gctgcactct gaccaaccgg tcgtagtgga tgtcatgatt ggaaacgaac cgccgcttcc 449941 tggcaaaatc acctacgggc aggcgaaagg ctttagcaag tacatgctga aaaacttctt 450001 cgaaaaccaa aaatttgaaa tgccgtcact gaagaaaagt ttgaaacggt tattttaaaa 450061 aaacaggggc cctaagagcc cttgtttttt tttttttttt tggaaacaaa tgtattttca 450121 gcatgtttga attcataaaa tgatcggtat atgtattagg aactgatttc gccatactcg 450181 aaacagacaa aaggacaaat gcatcttgtt tcaaaggaag atgcatttgt ccttgcatgc 450241 ttattcttat caaatcttac agaactcttc tcataatagg ttatttttct tttttcttca 450301 gcccgaagaa gaaaggaaaa gcagaaccga ccaagaaggt gccgaataaa aacatgccgc 450361 cgataaacac gtggaaattt gtgtgtccgg ccgtaaacgc cgtgattagg gaaatgatac 450421 tgagcacgat catggcaatg ccgggcgcga ctctcatttt tcccttggat ttatgggcag 450481 caacagaaca taaaatgccg ataacaatag gaacaatcca caaataaaac agaataaata 450541 ctgacatcat caaaactccg atttttcttc tatcataaca aatttctgtc aaaaagggta 450601 tcaatgagct tttgcggaaa aataaaaacc ggctttagaa gccggttttt ttatcgaaac 450661 gtatctacaa ttaaaaacac attcaaagca acgatcaata cagcaatcag ccaagacacc 450721 actgtgatcc atttggcgtt gatcagagat cccatgatcc gtttattgct tgtaaacata 450781 ataagcggaa tgagggcaaa ggcgatcccg aaggacagca cgacctggct cagtacgaga 450841 gcggtcgtcg gattaacacc tgacgcgatg atcaagatcg gcggaatgat cgtgataaaa 450901 cgccgtacat acagcggaat gcggtagttg ataaatcctt gcataatcac gtcgcctgaa 450961 agtgtgccga cagacgaact ggatagaccg gcaacgagca gcccgatccc gaacaaagcc 451021 gcagacatag ggctgacaag atgtccgaat tgctgaaatg cgacgtcgag atcctcaaca 451081 aacaggccgt ttttgaagaa taatgcggca gccacaatca gcatacttgc attaatagcc 451141 cctgcaatca gcatcgctat taaaatatca ataaattcaa acctaaagat ttttttccgt 451201 tctgcatcag ttttgccaac cacccgccgc tgtgtaaggg cagagtgtaa ataaatggcg 451261 tgcggcataa cagttgcgcc aagaataccc gctgcaagaa gcacactgtc ggtgccatga 451321 aacgccggga caaaaaggcc cttcatcact gacacggcat caggctttgc gaaaaaggtc 451381 tgcaacgcaa aggcgatcac gaccacaaac agcataccgg caatacctgc ttcaagtgag 451441 cgataaccac ggcgctgaag ctccaatatc gcgaaagaac cgatcgccgc aataatagac 451501 gcttcaagca tcggaatgcc gaacagcaaa tacagtccca gagccgctcc gataaattcc 451561 gccagatcag ttgcgataat gaccaactcg ccctgaatcc ataatccgat cgagacaggc 451621 ttcgggaatt cttcacgggc aacctcaggc agatttttgc ctgtcgcaat accgagtttg 451681 gcggataggg attgaattaa aagcgccatg atattggaaa ataagatcac ccataagagc 451741 atatatccgt atttagaacc cgccgaaata ttcgttgcga agttgccggg atcaatatag 451801 gcaatggctg ctataaatgc agggccgaga aaagggagca gccctctgaa tcctctgatt 451861 ttcccgtcaa gcgcatcttg gacggctttg gaacggggag attgtgctgt gatgtccttg 451921 ttcatcatgt ctcacctgaa ttctgtttgt ttttgccgta caacaaagag tttccttaag 451981 gcaaattatt ttatctacat catatgacca tcccggtttc ttgtcaaccg aaaatgttca 452041 aaatacactt ctgaattttt ccctgttatg taacatgata tgtagggatt cgtgataagg 452101 tcccatataa aaagacatcg tttcatttcg aaacgatgcc tcctgtatct aatgagtcta 452161 ggcttccttc cgcagcccgc ggaatataag gcccagcaag aacacgaaga tggctgcccc 452221 gatgatggcc gggaaaatag caaagccggc gaggctcggt ccccatgtgc caagaagtcc 452281 gtgcccaatc caagcgccga tcagcccggc aatcatagag ccgaaaattc ctcccggcag 452341 ccggtttcct acaatggcgc tcccaattaa tccgataaca attgcaacaa ctaatgaaac 452401 caaaaagcta agcatcatga tcacctctca taaatgattt accaatcaat aaccgctcct 452461 gatcatttcg aaacacttga aagcatattc ctttatgatc ctgttttaat ctttctctgc 452521 acactgccgt cagctaaatg aacaatgacc tcagtgcctt tatgcgccgc gatttccttt 452581 gcccgttcaa tcgcttcttt ctttgtatcc ttgatttcag acacacgttt ggcgccctcg 452641 gctttgactg cccagccttt tttatgctta ataacatgct ctgctttatt catgagctcg 452701 gggccgctgc cgctgcttgg atcagcatcg cgttctgtct catcatcatg cgtcaggaaa 452761 tcatcaattt catctgtaga ggcgttttcc gcccattcct tcgctttgct tgtcgcaatt 452821 ggaatcgcgc gcccttcctc atagccttca tcaatcatcg cattcgcaat gtctatcgcc 452881 ttttttctca ccggcttctc aagatttttt aatgaagcag gataatcctt catcgaccaa 452941 ggcatgtcta tcactccttt tccttttata aaaatggtac ccgcaggtga aaaataaaaa 453001 cgcatccgaa aaaatgaagg tatactatat agtagaaaaa acggaaggga agtgcgggtt 453061 gggtgccaac agaacgaaaa gaagacttac atcagcaatt aaaagagata gagaaatggg 453121 aaaaagatca gcaaaaagtc tggttttggg aaaagctcag ccgtctcccg tttcaactcc 453181 tggacaagct gacaccagaa ttcatccaga aaaagatcgg caagctcttg gatgaggtcg 453241 gcagctttgt tcaaacaggc ggacagtacc tgacatctga aaaacagatt atcaggatgt 453301 ttcaaaagaa actgccggag gagatctttg aatcgctgga ggacatccgg aaagcgcctc 453361 ttcctgtcat ggatgaaatt gcggaaggaa tgggcaaaaa cagaaccaac gcagcaaccg 453421 ttcaaggcgc gacaaccggt gtgggcggcg tgtttacgct ggcggcagac attccggcag 453481 tgcttggctt atcactaaaa acattacagg atatcgcagt cgcatacggc tatgacccaa 453541 aggagaaaaa agaacgagtc ttcattgtga aatgcctgca gcttacgtcg gctgatgttg 453601 tcggcaaaag atcgattttg caggaattaa aacactacga tcaagaccgt acatataaga 453661 atgtcgcttc tcaaatccaa ggctggcgag aagtcgtttt gggctatcga gacacgtttg 453721 gctggaaaaa acttttccag atagtgccgg ttgccggaat ggtttttggc gccgctgcca 453781 atcgctcaac attaaacgac attaccgaga caggcatgat gctgtacaaa aagaggcgca 453841 ttcttgaacg actgaaagaa acagaacgag agatggaata gcagaaagca gacggacacc 453901 gcgatccgcc tgcttttttt agtggaaaca tacccaatgt gttttgtttg tttaaaagaa 453961 ttgtgagcgg gaatacaaca accaacacca attaaaggag gaattcaaaa tggcagacaa 454021 taacaaaatg agcagagaag aagcaggtag aaaaggcgga gaaacaacaa gcaagaacca 454081 tgacaaagaa ttctatcaag agattggtca aaaaggcgga gaagccacta gcaaaaacca 454141 tgacaaagaa ttctatcagg aaatcggcga aaaaggcgga gaagccacta gcaagaacca 454201 tgacaaagag ttctatcaag aaatcggtga aaaaggcgga gaagccacta gcgaaaatca 454261 tgacaaagaa ttctatcaag aaatcggccg aaaaggcgga gaggcaacaa gcaaaaatca 454321 tgataaagaa ttctaccaag aaattggctc aaaaggcgga aacgcccgca acaacgacta 454381 atcaaaagca taaaggcaga caacctgtaa ataaaaaagc gatccggcac atcagctgga 454441 tcgctttttt ttggaatctt ctcaatttat gccgctattg agatacaata agtgaaaaag 454501 gggttttcgc taatgtccaa gatgcaaaac ttgctcgcca tcgcaaatga agtcaaagaa 454561 aagcacgcca atttttcaat ctcagaggtc aacgaccact gcgtgcgcct tgcggtgttt 454621 acgggagaat atgactggca ccatcaccct gactcagacg aattgtttat tgttcttgaa 454681 ggggagctgc tgatcgattt taaggacaaa gaaaccgcgg tgctcaaagc aaatgacagc 454741 ctgctgatcc ctaaaggcac ggttcaccgc acacgctctt acgtcagaac ggtaaatctc 454801 tgtgtggagc ataaacaagc cgaaaccgtc atcatagagg agcagccatg ctaatcaaaa 454861 agatgatatg tgaagtagat gctgcaaacg ctgaagcatt tgcaaaagcg cagtcacagt 454921 gggaagcgtt atcgcatata agcggcttta tcaaacaggc cggcggctgg cgaaaaacga 454981 tagacgagcc gctcaccgca gaaatcatca gtgtatggga aaacagagaa gcctatgatc 455041 attttatgga gaacgaacat gacagcatat acgaggaaaa cgatcagaag gctgtaattc 455101 tttcgataga ggtgacggtg tacgaagagg ataaaccgtt cgttcacgat ctgttacata 455161 accccgatat ccggtacgaa ccaaactgga cggttctgaa ggcataatca aagcccaaaa 455221 catcatgttt tgggcttgtc tctttactcg cgtcccggaa gtgtattatg aacaaaaggc 455281 ggtgctggtt ttaactccgg tttttctcca aacgtttttg cttctttcac atattcaaag 455341 gcttctccgt ccggcgcttt ttcattcagc cagttttgct cggcgcttac ttcgccttca 455401 gagaaattga taagctgatg tgagaactct tgtttttcga gcgctttcgg gaatgtaccc 455461 ggcacaaccg gaccttcctg tgcttctaat tctttaatgg cggcgagcca ttggttctgg 455521 tgcatcgtgt cacgcgccag caggaagctg agcatatctt tgacgccttt gtcatccgtc 455581 atttcaaaca ggcgtgcgac ctgcagacgg ccctgagatt ccgcattcag gttggcgcgg 455641 aagtctgcca gcaggtttcc gcttgctacg atataaccgc cgctccaagg tacgcctgta 455701 ctgctttccg gcatggcgcc aagtcctgat acaatcgcat ggtgagggtt catgccgcct 455761 aggatggagc cgatgaccgg atcttcagca gctttttcct gctgatcaag aggggcatcc 455821 tcaagaagtc tggcaatcat cgttgcgatc atttcaacat gcccgagctc ctcagttgcc 455881 gtatccatca gcaagtcctt gtatttttca tttcctcttg tgttccagcc ttgaaataag 455941 tactgcatgg caactgaaat ttctccgaat tgcccgccta aaatttcttg cattttttta 456001 gcgaataatg gatctggacg atctggttta gcaggatgct gcagcatttt tgtgtgctta 456061 aacatgtacc catctccttt ttcgtttatc tctttttata tttccgatcg atagaaagat 456121 aaacgaaaaa cagcgtatcg agatgggaac tatgaatctt ttcgcagctc caacagttcc 456181 cggatcagct cccggccaaa gatgggctca tactgccggt aaacagggtc aagacgcttc 456241 atccattctt gtttctcttt atctgacagc tcataaatat gtatagcaga attctttttg 456301 atttcttcca gctgctcctt gttcatttgt tcggcatacg tttcattcca ctccgttgtc 456361 tccttcatcg cttcagtcaa aatgcgtctt gtttctggtg tttgcgcctt ccagaagtgt 456421 tcatcagtca tgacagcgta gccgagataa ccgtggctgc ttattgtcaa atagtcctga 456481 acattataaa attttttaga atagatgttt gaaattgtat tttcttcgcc atcgactaca 456541 ttgttttcta acagctgaaa ggtagaattg aaggattcct gatgaggtgt tgcgccaagc 456601 agcttgaact gatcctcaat cacatcgctt tgcataatgc gcagatcctg cccttttaag 456661 tcatccggtg ttttgaccgg cccttgattt gttgtgattt gcttaaagcc gttcgtccaa 456721 taggccaatc ctttcaattg gtttttcttt agagaatcaa acagctgtgt gccgatgctt 456781 ccgttcagcc cttttttgac ggcgttgtaa tctgtaaatg catacggcag atccagcact 456841 ccccattcag gcgagagcat gccgagcttc gatgtggagg gggcgataaa ttgaacatcg 456901 ccgttttgca atgcttcaat ttcttcaatg tccgagtaca ggcttccatt cggaaatact 456961 tctattttta tttttccgcc tgatttttcg ttcaccagat cagcgaattt attggcggcc 457021 agcccttttg gcgtattttc agcaaccacg tggctgaatt taaacacgat ttgatcctgc 457081 aggccttcct ggtcgtcatc ataaacaatc tttttattgc cggtatgatc atggaatccg 457141 ataaataaag cggttgcaat tccagcgatc atcagtgcga gacatgcaag caaactcttc 457201 atgaaaagcc ctcccctatg ttaaggataa tgggggctat gacattcgta aagacctgaa 457261 aggagaagct gatgaacaaa aagaagctct caatccgttg gaaaatcacg atcttatcct 457321 atatactcgt cattttctcc tttttgatcg gcggcattgt gctcatcggc aacattcagc 457381 atacagagga gcgggagctg aaaaagcggc tgatgaatac ggcccggacg gtgtcagaga 457441 tgacagaagt gaaagaagcc ttggcgcgaa aaaaacaaac agaagcggtt cgccatgcgg 457501 ttgaagaaat caggatgatt aatgaagcag actatattgt cgtcatggat atgaatcaca 457561 tccgatatac gcatcctgtc agcacaagca ttggcaagaa atcagaaggt gcagacgagg 457621 aggcagcttt tgcggagcac atttatttct ctgaagcaaa gggcgagatc ggcacggcgg 457681 ttcgcgcttt ttatccggta aaggatcaag acctgaacca aataggcgtg gtgcttgtcg 457741 gaaaaacgct gccggggatc gctgacatcc tgcttcattt aaagcgtgat atcgccttca 457801 tcgttgtgct gacactcggc tttggccttg ctggttcctt tttgctggcc cgccatatca 457861 aaaaacaaat gtttcagctt gaaccccatg agattgtccg aatgtatgaa gaacggacag 457921 cgacgtttca ctcgatgaat gaaggggtga tcgctattga caatcgtctc gtcattacga 457981 tcttcaatga aaaagcgaaa cagatctttg aagtgcaggg ggatctaatc ggcaaggtga 458041 tttgggaggt tctcaaggat tcgcgcctgc ccgaaatcgt ggagcggaac aaagcggttt 458101 ataatgaaga aattcgtgtc agcggtaagg tgatcatgag cagcagaatt ccgatcgtca 458161 tgaagaaaaa agtgatcggc gccgttgcga tttttcagga cagaacggaa gcggccaaga 458221 tggcagagga attgactggt gtcagaaact ttgtggaggc gctccgtgtc caaaaccatg 458281 agcatatgaa taagctgcac acgatcgccg gtctcatcca gctggggaaa tctgaaaaag 458341 ccttgcagct tgcattccag gcgtcaactg agcaggaaaa tgtgactgaa tttctgcacc 458401 gctcgattca aaatgacgct gcggcaggcc ttctattaag taaaatcaga aggggaagag 458461 agctcggcat tgctgttcat atagatgaaa acagcagtct tcagcaattt cccgagcatg 458521 ttgatcagca tgatattgtc gtgcttttgg ggaatctgat tgaaaatgcc ttcggctcat 458581 ttgaaaccgt tcaatctgaa gacaaacgaa ttgacattag tatcgaacaa acagatgata 458641 tccttgctat tttaatagaa gataacggct gcggaattga accgacacat atgcctcgcc 458701 tttatgacaa aggttttacg gtcaataaaa ctggcggcac aggctatggc ctgtatctag 458761 tgaaacaaat catagacaaa ggatcgggca cgatagaagt tgattcacat gcggggcagg 458821 ggacatcttt ttctatcgtt tttccaatga agggggagga agcacagcat ggctcgtaaa 458881 gaatggaagg ttctgctcat tgaagacgat ccgatggttc aagaggtcaa taaggatttc 458941 attacaactg ttaaaggcgt tactgtctgt gcaacggcag gaaacggaga ggaaggcatg 459001 aagctgatta aagaagaaca gccagatctc gtcattctcg atgtgtacat gccgaaaaaa 459061 gacggcatca agaccttgca ggagatcaga aagcaaaagc ttgaagtgga tgtcattgtc 459121 gtctccgctg caaaagacaa ggaaacgatc tcactcatgc tgcaaaacgg ggcggttgac 459181 tatatcttaa agccgtttaa gcttgagcga atgagacagg cactcgaaaa gtacaagcaa 459241 tataaacaaa aaatcgaagc gaatgatacg ctgtcccagg aacagctcga tgcgatcctg 459301 aatattccgc agcaggccgt acaggatctg ccgaaagggt tgaatcactt cacgatgaat 459361 gaagtcactg cttttttgaa acagcaaacc gcatcccttt ctgctgaaga ggttgccaag 459421 gcgctcggca tcgccagagt gacagccaga cgatatcttg attacttaga aaaaaccggg 459481 atcatcaaat tggacgttca atacggcgga gtcggccggc cggtcaaccg ctacgtgtta 459541 aaaggataaa cctgagacca aaaagaccaa aatgtccgtt atgatcataa acttccccag 459601 actgtatgaa aacgctatca ttctagtaag aaagacacaa aaggcgaata ggacaggggg 459661 atgaaggata tgaaactgtt taaaaattta acagttcagg tcataaccgc ggtcatcatc 459721 ggggtcattg tcgggctggt ctggccggat gtcggcaaag aaatgaaacc gcttggtgat 459781 acatttatca acgctgttaa aatggtgatc gcaccaatca ttttcttcac aatcgttctc 459841 gggattgcaa aaatgggcga tatgaagaag gttggaaaag tagggggaaa agcgtttatc 459901 tatttcgagg ttgtcaccac cctcgcactc attatcggtt tatttgtcgt caatattatg 459961 aagccgggtg cgggtcttga ttacagcaag cttgaaaaag gagatgtatc acaatacacg 460021 caaaatggcg gtcagggaat cgactggatt gaatttatta cacacattgt tccgtccaac 460081 atggttgatg ccttcgcaaa aggggacatt ttgcaggtct tattcttttc tattcttttc 460141 ggagtgggtc ttgcggcatt aggcgaaaaa ggaaaaagcg tcattgattt cttcgacaag 460201 gtttctcacg tttttttcaa aattatcggc tacattatgc gtgccgcgcc aatcggggca 460261 ttcggggcga tggcgtatac aatcggacac ttcgggctcg attccatcaa accgctggca 460321 agcttaatga tgtctgttta tattacgatg ttcctgttcg tatttgttgc tttaaatatc 460381 atctgcaagc tttacggatt cagcctgtgg aattaccttc gcttcattaa ggatgagctt 460441 ttgatcgtgc ttggcacaag ctcttccgaa tcggtgcttc cgcgtatgat ggataaaatg 460501 gagcgctacg gctgttccaa atccgttgtc gggcttgtta ttccgacggg ctattcgttt 460561 aacctcgacg gcacatccat ctatttatca atggcgactg tctttttggc acaggtgttt 460621 ggagtagacc tcagcatcgg ccagcaaatt acgattatcc tcgttctgat gctgacatcg 460681 aagggagcgg caggtgtgac gggaagcgga tttatcgtcc ttgcctcaac gctgtcagcg 460741 ctgcaggtca ttccgctgga ggggcttgca ctcctgctcg gggtcgaccg tttcatgagt 460801 gaaggaagag ccattgtgaa cctgatcgga aacggaatcg ccacgatcat tgttgccaaa 460861 agcgaaaatg aatttgatga agcaaaaagc atagaggctg ttgaaggcat gaaaaaaatg 460921 aaaacagcag tctgaaaaaa gaacggccca tccatgggcc gtttttttaa ttgtttaaga 460981 attattaagg taaggacaga gacctcagca tttttttgtt atataattta caaatggata 461041 ctatattgaa tgaaggacgt ttgtcctaac aggagtgtat aaatggccgc tttagttaaa 461101 ttttttcagc acccgggagt aaggcgtttc tccatctttg tcgtgttaac tggtgtgtta 461161 tatctattta agagcatgat caacttaata ttgcttacct tcattttcac atttctaatg 461221 gatcgtttgg agcttgtcgt gcggcagttt gtaagccagt tcttccgcgt gagccagcgg 461281 gttgtcatta cgtttcttta catgttgctg gctgtgctgc ttacagtcgg gggctttgtg 461341 ttttatccgg tcgtcgcggc gcagatccag cagctggtaa agcagattaa acatattgcg 461401 tatcatcctg acagcatccc tttctttgat gagatcacca gtgtcttcgg agatattaac 461461 atcagttcat atgtcaaaga gggcttcaat gtagtgtata cgtatctggc cgatatcagc 461521 acattcggct tgcaggtcgt gatggcgctc attcttagca tgtttttctt atttgagaaa 461581 aaacggcttt ctgaattcat ggcgaaattt aaaacgagca aacttagggt cttttatgag 461641 gagattgctt ttttcggaag caaatttgca agaacgttcg gcaaggtgct cgaggctcaa 461701 tttatcattg cgctcgtcaa ctgtattctg acgtttatcg cgctttggat tatgcatttt 461761 ccgcagctgt ttgggctttc gattatggtg ttcttccttg gattgatccc tgtagcaggc 461821 gtcgtcattt ccctgattcc gctcagcatt atcgcctaca gcactggcgg tggaatgtat 461881 gtgctctaca ttgtccttgt catattcgcc attcatgcga tcgaaaccta tttcttaaat 461941 ccgaagctga tgtcggcgaa aacagagctg ccaatctttt tcaccttcac agtactcatt 462001 ttctctgaac acttcttcgg catttggggt ttaattatcg ggattccgat ctttgtgttt 462061 ctccttgata ttctggatgt caccaacaag gaagataggt ctaaaggacc ccgagagaat 462121 agcgataaaa agtagtttaa aatcgaataa tgagtgtgcc tcgatctgcc ggcctgcctg 462181 ttcagggcat ggaattaaga ctcggaatcg gagcttggca ttgccttgca cagtggtgaa 462241 cacaacaggt gacaatgctt gtcatcagta cggaaactga aaagaacaaa cagtcggagc 462301 aaacgctcat catcggttta accaaacatt tggaagcaac aaatgctata atacaaacag 462361 tgcctaatgt tgggcactgt ttattttttg tcgaaaaagg aggaaggctt tatggctgag 462421 ccgattttac atattgaagg cctcgataaa aaaattgggt ctaaacagat tttaaaacag 462481 atcagcatgg acgtcatgga gggtgaaatc atcggccttc tcggtccgaa tggttccgga 462541 aaaacaacac tcatccgtat catcgtcggg ctgttgaaac aaaacagcgg aagcgtgaca 462601 atcagcggat tccagcatga tacagagttt gaaaaagcga tggaagcggt tggagcgatt 462661 gttgagaacc ctgagttcta tccgtacctg acaggctggg aaaacctcaa gcactttgcg 462721 aatatgcaca aaaaaatagc ggatgaacgg cttgatgaag tggtggaacg tgtcgggctg 462781 acgtcagcga ttcatgataa ggtgaaaacc tattcccttg ggatgcgcca gcgtctggga 462841 atcgcccagg caattcttca ccggccgaag cttctcattc tagatgaacc gacaaacggc 462901 ctcgatcctg cggggatgaa ggattttcgg gatcatatta aggaactcgc agaaatggaa 462961 ggaacagctg tcctgttcgc cactcattta ttgcgcgagg ttgaagactt gtgcgaccgt 463021 gtcatcatca ttcaaaaagg tgagatcaaa gcggaagtca gcttacaagg aaccgatcaa 463081 accacagaaa aagcgattat agaagtgcag ccgcaagaaa aagcgctcaa ttggctgaca 463141 ggcaatcaat atcaagctga gagccaagac gggacgattg tagttgaggt ggcaaaagaa 463201 aacataccgg agctgaaccg atcacttgtc ggacaagatc tgaatgtatt ttccattacg 463261 ccttacacgc agtcactgga agacgaattt ataaaagcga caacagctca tcaagaggag 463321 ggagaagagc ttgtctaaat taatttggaa tgaacatatg aaacttttta atcggaaggt 463381 cactttggtt tctcttatcc tgatggctgt ctttcaattc ttcatggcat tgatcattaa 463441 acggattgtc atcagtgccg gaacagatga aaacttcatc ggctatttat cgtatacacc 463501 gagcctgaac attttgctgc aggctttaac gatcgtaatt gcagcaacaa ttgtttcgat 463561 ggaatttgat aaaaagacga tcaaattttt gctcattcgt ccggttaaac gccaaaaggt 463621 cttttggtca aaattaatca cagtcgtgat ggtcagcttc tatttgtatt tggcatacta 463681 cattctggca ttattattcg gtctcttgtt ttttggcaca tcggtgactg cggaatcaaa 463741 gacattgctg gtcaacacct tggcgctgat cgggtcaaac tggcttgaag ctgtaatgat 463801 gggattattc gggctgcttt gttcttcgct gttccgcaat agcgcggtag cagttgttgt 463861 ttcttttgtc gttttatacg gagcgagtac acttgttcag ctcatgaagt tgtttgaaaa 463921 caagtggggc agctttttgc tttttgcgaa cactgacttt acgcaataca gaagcggaga 463981 gacagcgttg ttttcaggca tgacgccatt gttttcaatt ggaattctca tcatacatgc 464041 catattcttc atcgttgttg gctggtggtg cttctgtaaa cgggatgttc gggtctaaag 464101 gcaaggaatg acatttttgt gaaaaagctc acgtaaatca atatcatttg atattttggt 464161 ttatactaaa ggtactgacg gaggtgtctc gattgaggaa ctttattacc gctttaccga 464221 tcgtattgct gcttggattc tcatttgtgt cattcatgtt tcagtttgaa catcttgttt 464281 atttcaggct cgcgcttggg ttgttttctc tcgtgggact gtacatgata tataaaatga 464341 agacgggcat ccgctatttt atcatctatc tgtatgccag ctggattgtg ttggccgcag 464401 tgaccgcttt tgaagagccg attttctcaa gctttttctt tggcggcctg gtgatgacga 464461 tgggttacct gacatatatg ctgatttatc tcggcatgaa acaagaccgg gatgcaaatc 464521 ctgtgtaatc gcgctgttcc cttggggaac ggcgtgtttt tctatactgg gcaaaaggtt 464581 aacagttgcg gaaaaatggc aggaaatcta taatacatat taaatttatc ggaattaaaa 464641 ctggggggct gccggatgtc attatttata caaaacgatc aacagcggca atggatggag 464701 aaaatcggac ggattgcgga tgaatttcag caaacagctg ctgaagatga cgaacaggga 464761 cgttttcctg cagagaaaat acaaaaactg cgtgatgctg ggtatacagc attaacattg 464821 ccggcatctc atggcggagg gggcatttct gtttacgata tgctcttgtt tcaagaacgg 464881 cttgcacggg gagatgctcc gacggctctt agcatcggct ggcatttgag cgtgatcggg 464941 gagcttggag aaggcaacag ctgggatgaa gacgtatttg catttgttgc caaggaagtc 465001 caaaacggag ccgtcattaa cagggcggcg actgaagcga aaaccggaag cccgacaaga 465061 ggagggcgtc ccggtacaca cgccgtcaaa aaggatggca aatgggcagt gaacgggaga 465121 aaaaccttta cgacgatgtc acaagctctg gattattttt tagtaaccgc atggattgag 465181 gacaaacaaa caacaggcgt gtttctcatt cataaagatg atcccggctt gtcgattgaa 465241 gaaacgtggg atatgatggc gatgcgggcg actgggagcc atgaccttgt actgaacgaa 465301 gtaatgcttg atgagaataa gctggtggaa ctgcttcaag ggcctcgtgg agctaagccg 465361 aatggctggc tgcttcacat tcctgcgatt tatcttggtg tggctcaagc tgctcgtgac 465421 tatgcagtgc aatttgcatc tgagtattct ccaaacagct tgaatggacc gatcaagaat 465481 gtcccggccg tacagcaaag aacaggcgaa atggagcttg aactgctcaa tgccagacac 465541 tttcttttcc atatcgctca attgtatgac gatccggtgc ggcgtccaca cttgaccagc 465601 gagctcggtg cggcgaaaca tatcgtcaca aacgctgcgc tgtctgttgt tgataaagcg 465661 atgagaattg tcggggccaa aagcctggaa cgaaccaacc cgcttcagcg ctattaccgt 465721 gatgtgcgcg ccggtcttca caacccgccg atggatgacg ccgtgataca caagctggca 465781 gctgaagcgt ttgagtcata aaaaaaagag ccttaccggc tctttttatg tattgttttg 465841 ctcttgcaga tttttttgat gcttgcggtc gatcctgtca taaataacgt tcatcagctt 465901 tggattgccc ataatcgcct ctttgttttc ctggatcagc tgttggtaag ttttcacttt 465961 acgcttcggc atgctccggc gccctcctga catgtttgta ttcactttct aactccgtca 466021 gcgacaattc atacagatga cgctttgact ttttgtatat accattctgt attaacagat 466081 gaatgagctg tttttttctg atttctgcag actgaggtgt cattgtgtca ccaacctcca 466141 atcaaacgat attgataatc attatcaatt aacttcagta tacaatgtcc gcaatagcct 466201 gtaaagatga aaagagtcct attcttggcc aatttacaaa cattcaacaa atcgacaaaa 466261 agtttcccgg gcaataattt gctgtcgaaa tattccgctt cattgaacgc accctgctat 466321 ttttcatgtt ttgaaccata ctatgtaata gaatggaggc tggtattcaa tggagcggac 466381 agaaaatctg aaaaagggag aaaaaggggc gctcctcaat atttttgcat atgtcatcct 466441 tgctgttgta aagctagtta tcgggattct atatcattct gaagcgctga gagcagacgg 466501 gttaaataat ggaacagata ttgttgcgtc agtagcagtg ctgataggat tgcggatttc 466561 tcaaagaccg gctgacagcg atcatccata cggccattat cgggctgaaa caatttcgtc 466621 tcttgttgcg tcttttatta tgatggcagt cggcattgaa gtgttaatcg gcggaggaaa 466681 agcgattgcg ggcggcacaa cggaaacgcc aaatcttatc gcggcatgga cggcgttagg 466741 cagtgctgtg tttatgtatg gcatctattt atataacaaa aggctggcag cgtccattaa 466801 aagctctgcc ctgatggcag cggcaaagga cagcaggtca gacgcttttg taagtgccgg 466861 cgcgtttatc ggtgtttttt cgtcccagct gaagctgccg tgggttgatc cggtaacggc 466921 ttttatcatc ggcatcatca tttgcaaaac tgcgtgggat atctttaaag acgcttcaca 466981 ttccttaaca gacggcttcc atttaaaaga tcttgagcct tacaaacaga ccgtcggcag 467041 gatcgaaaat gtgcatcgcc taaaggatgt gaaagcgagg tatttaggca gtacagttca 467101 tatcgagatg gtgattacgg ttgatccgaa gcttacagta gaagaaggcc atggagtggc 467161 ggatgaagta gaagacaaaa taaaacatga acacgatgtc actcatgttc atgttcatgt 467221 agagcctgac gacataaaat aaggctgttt aacgaattag cttatatgtt cagataaaaa 467281 ttcagtcact tcttcaggcg ttttggcatt ggcgctgtga aggtgagctg ttttttcacc 467341 gttcttgaaa ataagcaggc tgggaatgcc cattacttgg tatttttcag ccaggtcagg 467401 aagctcgtcc ttattcagct cataccagtc gttttggttg tattcttcca aaatatcgcc 467461 gatgaacata ttcatgcgtg tgcagtctgg gcaccaatca gcataaaact ttacaatgat 467521 ttctttatca gattgaatca gttcattaaa ttgttcgttt gttgtgattt ttttcatatg 467581 tcacatctcc ttttcaatgc cattttaata taaaataaaa aggaattaca tacaaatgca 467641 ttcaacatca gcatgcccaa aaataattag atcattttcc ggtgaaaatg ataagatagt 467701 aaagatgaat tgtagtgggg ggagtatcca ttgaaaacaa gtctaggatt agtgtacgga 467761 ggaaagtcgg cagaacataa tgtttccctg cagacagctc tggctgtaat caaagcgcta 467821 aatactgaga agtttgatat acatccgatt tatataacag aaaaaggcga atgggttaga 467881 ggcgcccgtt taactgaacc tgtttcaaac gtgaaaatgc ttcaatttga gcaaggaggc 467941 agtgcttttt ctccagctgc cctgaaccag gagatgtttc cgcaggaagc gtcacagcaa 468001 aatgaagcca tcgacgtcgt attcccgctc ctccacggac cgaacggaga agacggtacg 468061 atccagggaa tgctcgagct gttgaacatt ccttatgtcg gcaacggagt gcttgcttcc 468121 tcagctggca tggataaagt tgtcatgaaa catttatttg cgcaggttgg ccttgctcag 468181 gctaaatacg cagctttcct taagaaagac tggactcgtt ctccgaaaga aagctgtgag 468241 gaggttgaac aggaattagg ctacccttgc ttcgtaaaac cggcgaacct cggctcaagt 468301 gtcggaatca gcaaatgccg aaaccgtgaa gaactgcaaa aagcgtttga gcttgctttc 468361 caatatgacc gcaaagtcgt cgttgaagaa ggaattaacg gccgcgagat cgaaatcggc 468421 gttcttggaa atgatgatcc taaatgctct gttgtgggag aaatcgcacc gaagacagat 468481 ttctacgatt acaaagcgaa atatgaggat ggagatactg atctgatgat tccggcgatt 468541 gtgactgatg aggaatacgc aacaatcagt gatatggcga tcaaagcgtt taaagcgatc 468601 gacggttcag gactcgtcag agcggacttt ttcctgacag ctgacggcga agttctgatc 468661 aatgaagtca acacaatgcc tggctttaca cctttcagca tgttcccgtt gctctggaaa 468721 gaagccggag tggaatatgc tgacctgatt gaacagcttg tggagcttgc aaaagaacgc 468781 cacgctgaaa aacaattgat taagcataca ttctaatgaa gaaggacact gccggtaaaa 468841 gggcagtgtt ttttcccgta tatacaaaag aaagagaggg accttacttg attaagcgaa 468901 cagtaaaaaa cattgccgaa atggttaaag gcacactagc aaatccgcaa tatgaacaaa 468961 cagtcattca tggagtggca accgatacaa gaaaactgga acaacatcag ctctttattc 469021 cgctgaaagg ggaacgtttt gacggccact cttttgtgga gcaggccttt gaagctggtg 469081 tagcggctgt tctttgggat cggtcagtac caaatccgcc cgagaatcac gccgtcattt 469141 tagtggacga tacccttact gcacttcagc agcttgcaaa agcttatttg caggagcttg 469201 gcacgcgtgt catcggagta accggaagca atggcaaaac gacaacaaaa gatatgattc 469261 acgccgtatt ggggacccag taccgtgtcc acaaaactgg aggaaacttc aataatcata 469321 tcggtttgcc gctgacggtt ttagcgatgc ctgaaaatac ggagatcgcc gtattggaga 469381 tgggaatgag cgccaaagga gaaattgacc tcttgagccg actggcaaac ccggatgcgg 469441 cagtgattac gaatatcggc gaatcgcata tgcaagacct cggctctaga gagggcatcg 469501 cggaggcgaa gcttgaaatc ataaacgggc ttaaagaaga cggagtgctg atttatatcg 469561 gggacgaacc gcttcttcaa aatgcataca gctgccagac gaaaacgtac ggtacgggaa 469621 cgcataatga ttatcagctt caggatgtca gccagagtga ggaaggaacc cattttacaa 469681 tcaaagggat agaaaacacg ttttttattc caatactcgg caagcacaat gtgatgaacg 469741 ccatggctgc aattgctgca ggggcttatt ttggcatcgc gcctgaggat gcggcaaaag 469801 gactgagcgg cctaaaggta accgggatga ggcttgaact catcaaaaca gacagcggcc 469861 tttcgataat caatgacgct tataatgcga gcccgacttc catgaaagct gcaattcaat 469921 tgacagaaag ccttgaaggc tacggcaaaa aaatgctcgt gctcggtgat atgcttgaac 469981 tcggcgatct tgaagaaacg ttccataaag agtgcggcgc tgtgatcagc cctgataaaa 470041 ttgaccgcgt ctttacgtac ggaaaactgg gagcttttat cgcggaaggc gccctgaaac 470101 actttgagaa agaccgcgtc agccattaca ctgagaaaaa agatctcctt caagctgtga 470161 aggaaaacgc atcaaaaggc gatttgattt tattcaaagc gtccagaggt atgaagcttg 470221 aagaaatcgt taaagattta atagagagcc cgctttcata agaaaatatt ttgcgaaaaa 470281 acgcatattg catcataaaa taacctgata tgcaaacact aatgtatgcc ggccgaaaat 470341 tatgtatatc tggccggctg cggctatgat acaatatata taggttattt cgcgatacga 470401 acatattcgt ccggactttt catcgtgacc cgaagttctc cgctggattc ttgggagcgg 470461 atggagcagc agccggcata ttcgagatgc cgatctgctt ctcatcttat tgaaaaacaa 470521 atagtgtaat ggtaagataa aacttaaagt aattcgggct ttgtatacgg atggatcctg 470581 tccttcttgt ctaaagggca gttttataag tggtaaatca cgacattact gaaacagcaa 470641 ttagaaggag tttgaataat ttgactataa cgtttcaaga ttttaattta agttctgatc 470701 tcatgaaagc aattaatcgt atgggatttg aagaagcaac accgattcag gcacaaacga 470761 taccgctcgg actttcaaat aaagacgtca ttggacaagc gcaaacaggt acaggtaaaa 470821 cagctgcgtt tggtataccc cttgttgaaa aaattaaccc cgagtctcct aatattcaag 470881 caatcgtaat cgcgccaacc cgtgaattag ccattcaagt atctgaagaa ttgtataaaa 470941 tcggacaaga taaacgtgcg aaggttcttc ctatttacgg cggacaggat attggacggc 471001 aaatccgggc gttaaagaag aatccgaata ttattgtcgg aacacctgga cgtcttcttg 471061 accacatcaa ccgccgcacc attcgtttaa acaatgtaaa taccgttgta atggatgaag 471121 cggatgaaat gctgaacatg ggattcattg acgatattga atctatcctt tcaaacgtgc 471181 caagcgagca tcagacactt ctgttctctg ccacaatgcc tgcgccgatc aaacgcattg 471241 cagagcgctt catgactgag ccggaacacg taaaagtaaa agcgaaagaa atgacggttt 471301 ctaacattca gcagttctat ttggaagtgc aagaacgtaa aaaattcgat acactgactc 471361 gccttcttga tattcagtct cctgagcttg cgatcgtatt cggacgtaca aaacgccgtg 471421 tcgatgagct ggctgaagct ctgaaccttc gcggatatgc agctgaaggt attcacggtg 471481 acttaacgca ggcgaaacgt atggttgcgc ttcgtaaatt taaagaaggc gcaatcgaag 471541 ttctagtcgc aactgatgtt gccgctcgcg gacttgatat ctcaggtgtt acacacgtat 471601 acaacttcga cgtgcctcaa gatcctgaaa gctacgttca ccgtatcgga agaacgggcc 471661 gtgcaggaaa aacaggtatg gcgatgacgt tcattacacc gcgtgagaaa agcatgcttc 471721 gcgcaattga acaaacaaca aaacgcaaaa tggaccgcat gaaggagcct acacttgatg 471781 aagcgttaga aggtcagcaa caggttactg ttgaacgtct tcgcacaaca atcagtgaaa 471841 acaacctgaa cttctacatg acagcggcag ctgagctgct tgaagatcat gatgcagtaa 471901 cagtggttgc ggcggctatc aaaatggcta caaaagagcc agacgacaca ccggttcgct 471961 taacagacga agcgccgatg gtcagcaaac gctacaagaa ccagcgctct tctaaacgca 472021 gagacggtca aggcggcggc taccgcggcg gaaaagggaa aagcaacaac cgttcttcct 472081 atgacaaaaa gcgttcaaac gatcgccgtt cttcaggtga cagacgccag aaaaaatctt 472141 actaatttga tcgattcaga gcccaaaaca tgatgttttg ggctttttta tgttcgtgat 472201 ttgttattca gcaaactttc agctgacgga agccattttt ctctgtatgc ttaagaatga 472261 aacctttctg taaaagagac gtataaataa cgacgaaaaa aagggaggta ggtatttttg 472321 agagagcagc caaaaaacca aatcagtcca gacggattaa aggtttggcg acttcaagag 472381 atcatcatat ccgctgtttg cttgcttatt gtcattgcag ttgcagtgtt aagctattat 472441 tttcattggc cgtactggat cagcggcgtg ctcggcgctg tttggctgct gggatcgatt 472501 gtgacggtct ttatcattcc gaaggtccgt cataaggtgt ggcgatatga agtccatgaa 472561 catgaaatag atattcagtc aggtattttt gtggtgacac gtgtgattgt tccgatggtc 472621 agagttcagc acgtcgatac gtcacaaggg ccattattaa aaaaatacaa cctggcaacg 472681 gtgaaaattt ccacagccgc gaccgttcat tcgatccccg ctttagagat ggaggaagcg 472741 gatcggctaa gagactccat ttcccgtctg gcgagggtga ctgacgatga tgtctgaacc 472801 gaaacgcctg cacccggtgg cagtcatttt gaatttatgc cataccatta ttcaaacgat 472861 aaaaaatatc attctgccat tcttttttgt gtatattgtc aattcaaacc atactgtccg 472921 tttttacgga gccattgcgc tcggtgtgct gttcatctgg cttgtagcgg caagcattat 472981 caaatggaga aggtttacct atcgaattga agatgatgaa tttagaattg aagaaggctt 473041 atttgttacg aaaaaacgat acatatcgat tgatcggatt caaacaatga atacgagcgc 473101 gggccttgtc cagcaaatct ttaagcttgt gaagctgcaa attgaaacag caggcggagg 473161 caaggaggca gaagccgttc tttctgctat ttctgttgaa gaagcggaac gcatcaaaga 473221 agctgtcttt aagaaaaaag cgcaaagacg agaaaatgaa cttgatgaag aacggcttga 473281 agctgaagag gagttggatc cgtccgttga ggtgcaagag cactatcgca tgaacgcgaa 473341 agaattgctc atggccgctt ctacctccgg cggaatcgga gtcattatct ccgctgtatt 473401 tgcacttatt tcccagcttg atgaagtgct gccgatggat tggttattcg ataaattttc 473461 cttccttcag cacgccagca tcggtattta tgcggtactc atttttatcg gtttatttat 473521 cgcctggatt ttcagcatcg cgggcatgat gtttagatac gcgaactttc aaatcataaa 473581 aaaagagcag gaactggtga tttcaagggg aattattgaa aaacatcaag tcacgattcc 473641 gctgcgaaaa atacaagcca ttaaaatcaa agaaaatatc attcgccagc ttttcggctt 473701 tgtaacggtg tccatcgtca gcgcaggagg cggcgaccgg gaaaaagaag aaggcgcttt 473761 gaccattctc tttccaatga ttcataaaaa aaagcttccg cacatgctcc gaacatttac 473821 gccggaatac acgctggaag aaaactgccg ccgcctgccg cggcgcgcgt tgaaacgcta 473881 tttgttccgt tctgtcattt tttcactctt tttgatcatc ccgttatgta tcttctttca 473941 gccatggggc tatctgtcag tgatcctgct gccgatagaa ttgctcttcg gctatctcgc 474001 gtataaagag gctgcatgga cgatcaacgg ggaccgtctt cagctgacgt ctagatttat 474061 aggcagaaca accgccattg tactgaaaaa acgaatgcag gtctgcaagt tcagccaatc 474121 ctatttccaa aagaaaggcc gcttgtatac catttctact tcggtgaaat catcgagcca 474181 tatggaagag ttaacggtga gggacgtagg tgaagaggat gcagccttca ttttaaagtg 474241 gtactcatat gaaaaagcgg acggttaata ccgccgctcc agcgtgtcgg caaaccctcg 474301 cattcgttgt caggactgcg cttcggtgct caatgcgaag tggatcaacg gctaaattct 474361 caggcgtcct gcctaaacgc cgtcgtcatc acatcctgtg aaagtccgct cctatgctcg 474421 tccttcctag acttcatggg ttttcaatca cgctgaaaag atgacaaaat cctaaaatga 474481 aaaccatttt aggattttgt caacaatctg aagcggcggt taataccgcc gctctttttt 474541 ttgcacgcat aaaaacgaaa gaagaaaccc gccgcatagt ccaaacaaat gggccatcat 474601 gttaatattg gagttgataa acgacatgag aacggcaaat gcgagcagtg tgatgatcat 474661 tttggaatgc tcctgcccaa ttaactcatt gcgaaaaaga accataaaca ggtatacgcc 474721 aaatagcccg aaaatggcgc ctgaagcccc gacatgcacg taatcaagcg gctctgtaac 474781 ataagtgccg atattgccga tgatgccgga gccggcgtat acaagaagga aacgcgcttt 474841 tcccagcatg cgttccaaag ccggggcaaa taaaaagatg gacatggaat taaacagcag 474901 atgtgtgaaa ccggcgtgca gcaaaatcgg tgtgataagc cgccaccatt caccgtttgc 474961 gacacctaga ttatagcctg tgacggtatc cctccataac acgactgaat gggcaggaag 475021 tgaaaaaaac agccagagaa cagcttgcaa agccaatata aaggtgacaa cggggtaaag 475081 cctgataaat gtttgaaaat tttcagtccg tataaacatt ccgagcccct tttcttcatt 475141 ttggtatatc tatagtaaca cgtttatgag acaaaccatt taaatagtac gtacgcaaag 475201 gaggttatca tacatgattt acggcattgg gctggacatt accgagctta aacggatcgc 475261 ctctatggct gggcgccaga aaaggtttgc cgagcggatt ttgacgcgaa gcgagcttga 475321 ccaatactat gagctttcag agaaaagaaa aaacgaattt ctcgcgggca gattcgcggc 475381 aaaagaagcg ttctcgaaag catttggcac cggcattggg aggcagctca gctttcagga 475441 cattgaaatt aggaaagacc aaaatggcaa gccctatatc atttgtacga aactgagcca 475501 ggccgccgtt cacgtatcga tcactcatac aaaagaatac gctgccgcgc aggttgtgat 475561 tgaaaggttg tcaagctagt ctgcatatta gggaaacccc actcatatat ttgatagtgc 475621 attaagggag acaagttgtt tgaggctttt atggtacgca tctgttctgc ctaaacgtgt 475681 accgagcgta ccgttaaagt caaacaagcg atttcttcct tttacatcaa ttgagaaaaa 475741 ggggttgaaa aaggtgagaa aaagctttgt tttgctttta acgggactgc ttgctgttct 475801 tattctttct gcctgcgggc aaaaaacaca gcaagatatt gtggccgggt tagatgaaaa 475861 ggcgaaagaa tacacctcgt acaaagcaaa agcgaaaatg accatcgaga cagggagtga 475921 gcctcaagta tacaatgtgg aaatctggca caaaaagccg tctctgtaca gggtttattt 475981 agaaaatccg aaaaaggacc aaaaccaagt cattttacga aatgaaaacg gagtattcgt 476041 tctcacgccg tctttaaata agagcttcag atttcaaagc gattggccga acaacagcag 476101 ccaggtttat ctgtttgaat cgctcgtaaa ggatgttcaa aacgattcgg atgcagtttt 476161 cacagcgaaa gaaaagaaat acgtatttga aacaaaaaca aactatcagc ataacaaaat 476221 gctgcccacg caagaaatca catttaacaa aaaagatatg agcccgtcat ctgtcaaagt 476281 gatggatact gaccggaaag tgatggtcaa agtagaattc agcagctttg aatttaataa 476341 acaatttgat aaagaatcat ttgatgaaaa gaaaaatatg accctttctc aaatggatgt 476401 cgccacaagc gcaaagcctt ccgatacatt tgcggtcaaa acgccgctgg aactgccgct 476461 tggcgtcaag ctgcttgaag aaaaagatat atctactgaa gacgggaagc gcatcatcat 476521 gacgtacgga ggagaaaaat catttacgtt aattcaggaa aaagcccaga ttgccaaggc 476581 ttcctcctcc gttacgctga acggcgaacc ggtaaatctc ggctacacca tcggcgccct 476641 gtcggatgca tcattatcat ggacatatga cggcgtagat taccttctct cttctaaaga 476701 tctttctaaa gaggaaatgg tgacagtagc gaaaagcatg cagggacaat catcgaaata 476761 accgccaaag gccaaacatg atttggcctt tttttcgtta gacatcgttt ccctttagcc 476821 tttaatttta gtatgatatg taaatgatat tgaataaaag ctaggaagtg tcgtaatgag 476881 cacaaaacct ttttacagag atacgtgggc ggaaattgac ttgtccgcga taaaggaaaa 476941 tgtcagcaat atgaaaaaac atatcggtga acatgtccac ttgatggcag ttgtgaaagc 477001 aaacgcctac gggcatggtg atgcagaaac agcaaaggct gctcttgacg caggtgcttc 477061 atgcttggcc gtggccattt tggatgaagc gatttcactg cgcaaaaagg gattgaaggc 477121 gcctatattg gtgcttggcg cggttccccc ggagtatgtg gcaatcgctg ctgagtatga 477181 cgtgacctta acaggttatt ctgttgaatg gcttcaggag gcagcccgcc acacgaaaaa 477241 aggttctctt cattttcatc tgaaggtcga tacggggatg aacagacttg gtgtaaaaac 477301 agaggaagaa gttcagaacg tgatggcaat tcttgaccgc aaccctcgtt taaagtgcaa 477361 aggggtattt acccattttg cgacagcgga tgaaaaagaa agaggctatt tcttaatgca 477421 gtttgagcgc tttaaagagc tgattgctcc gctgccgtta aagaatctaa tggtccactg 477481 cgcgaacagc gccgctggac tccggctgaa aaaaggcttt tttaatgcag tcagattcgg 477541 catcggcatg tatggccttc gcccgtctgc tgacatgtcg gacgagatac cgtttcagct 477601 gcgtccggca tttaccctgc attcgacact gtcacatgtc aaactgatca gaaaaggcga 477661 gagcgtcagc tacggagccg agtacacagc ggaaaaagac acatggatcg ggacggtgcc 477721 tgtaggctat gcggacggct ggctccgaaa attgaaaggg accgacatcc ttgtgaaggg 477781 aaaacgcctg aaaattgccg gccgaatttg catggaccaa tttatggtgg agctggatca 477841 ggaatatccg ccgggcacaa aagtcacatt aataggccgg cagggggatg aatatatttc 477901 catggatgag attgcaggaa ggctcgaaac cattaactat gaggtggcct gtacaataag 477961 ttcccgtgtt ccccgtatgt ttttggaaaa tgggagtata atggaagtaa gaaatccttt 478021 attgcaggta aatataagca attaacttac ctaaatggag aattcataaa acagctttgc 478081 ttgaagagtg aataatggta tcattatcac tggatggata aaagagtcgt atccgtaagt 478141 ttggtggagg tgtatgtttt ttgtctgaat ccagcgcaag aaccgaaatg aaaatcagct 478201 tgcccgaaaa cctagtagct gaattggatg gtgtagcgat gcgggagaaa cgaagcagaa 478261 acgaactgat atcacaagca gtgagagcgt atgtcagcga acgaacaact cgtcacaacc 478321 gtgatttgat gagacgcggc tatatggaaa tggcgaaaat caacctgaat atttcttctg 478381 aggctcactt tgcggagtgc gaggctgaaa cgacagttga gcgcttagtc agcggaggat 478441 aatcatttga ttgtgaaacg cggcgatgtt tattttgctg atttatctcc tgttgttggc 478501 tcagagcaag gcggggtgcg cccggtttta gtgatccaaa atgacatcgg aaatcgcttc 478561 agcccaactg ctattgttgc agccataaca gcacaaatac agaaagcgaa attaccaacc 478621 cacgtcgaaa tcgatgcaaa acgctacggt tttgaaagag attccgttat tttgctggag 478681 caaattcgga cgattgacaa gcaaaggtta acggataaga ttactcatct ggatgatgaa 478741 atgatggata aggttgatga agccttacaa atcagtttgg cactcattga tttttagaca 478801 tatttgcagg ttgctcaaat agagcaactt tttttgtttt caaaaaacat aaacgatata 478861 atagtgaaat aacgaaaaaa tatgttgttt tttattggga ggtaagcgaa tttgatgtcg 478921 aaccagactg tataccagtt cattgccgaa aatcaaaatg aactgctcca actgtggact 478981 gacacactaa aagaattaag cgagcaagaa tcctatcagc tgactgacca agtgtatgaa 479041 aatatatcta aagaatatat cgacattctg ctgctgtctg ttaaggacga aaatgctgct 479101 gaaagccaaa tcagcgaact ggcgcttcga gcggtccaaa tcggactgtc tatgaagttt 479161 ttggctactg cacttgccga attctggaag cgtctctaca cgaaaatgaa tgataagaga 479221 ttgccagatc aagagagcac ggaattaatc tggcagattg atcgcttttt cagcccgatt 479281 aacacagaaa tttttaatca atactcaatc tcatgggaaa aaacagtatc cctgcaaaaa 479341 atcgcgctgc aagagctgtc tgcgccgctt atcccggtgt ttgaaaatat cactgtgatg 479401 cctcttgtcg gaacaattga taccgaacgc gcgaaacgaa ttatggaaaa ccttcttaat 479461 ggcgtcgtca aacaccgttc ccaagtcgtg ctgattgaca ttacaggtgt ccctgtcgtc 479521 gatacgatgg ttgcccatca tattattcag gcatcagaag ctgtaaggct tgtcggagca 479581 aaatgcctgc tggccggaat ccgtccggaa attgctcaaa caatcgtcaa cctggggatt 479641 gatttatccc aagttataac taagaatacc ctgcaaaaag gaattcaaac agcattggaa 479701 atgacggatc gaaaaatcgt ttcattgggg gaataacatt ttgagacatc cgaaaatccc 479761 gatcttgaaa ctgtataatt gcttattagt gtccattcag tgggaacttg atgaccagac 479821 agcattaact tttcaagaag acttattaaa taaaatatac gaaacaggtg ctaacggagt 479881 cgtcattgac ctgacatctg tggatatgat tgattcattt atcgcgaaag tgctggggga 479941 cgtcattaca atgtctaagt taatgggggc taaagtcgtc ttgaccggca ttcagcccgc 480001 tgtggcagtg acgctgattg aacttggaat cgcgcttgag gaaatcgaaa ctgcgctcga 480061 cttagagcag gggcttgaga cattgaagcg ggaattgggg gaatagcgaa tgaacgacca 480121 atcctgtgta agaatcatga cagaatggga tattgtggcc gccagacagc tgggacgaaa 480181 cgttgcgaaa gaactgggtt tcggcacggt agaccaggct agaattacaa cggctatttc 480241 agaattagcc aggaatattt atttatatgc cggcaaaggg cagattggaa ttgaacaggt 480301 cgcagacaga ggaaaaaaag gcctgaaaat catagcggaa gaccaagggc cgggaattcc 480361 tgatatccga aaagtcatgg aagacgggtt ttcaacgtct ggaggacttg gtgcgggact 480421 tcccggggtc aaaaggctga tggatgaatt cagcttaaat tccgtagcgg gggaaggaac 480481 agagatacaa gccatcaaat ggcttcggta ggaggtaaga acgtggattt tagggaggtt 480541 attgagcagc ggtatcatca gctgcttagt cgatatatag ccgaattaac agaaacatct 480601 ttatatcaag cccaaaaatt cagccgaaaa acaatcgagc accaaattcc tccggaagaa 480661 atcatcagca ttcacagaaa agtgctgaag gagctgtatc caagtctccc ggaagatgtg 480721 tttcattcgc tggatttttt aatagaagtc atgattggct atggaatggc ttatcaggag 480781 catcaaaccc ttagagggat acagcaggaa atcaaatcag aaattgaaat cgcggcaaat 480841 gtccagcaga cgcttctcgg aactaaagtt cctcaggagg aagcgctgga tatcggcgcc 480901 atcagtgttc ccgctaaaca gatgagcggt gattactacc actttgtcaa agacaaggaa 480961 tccatcaata tcgcaatcgc ggacgtgatc ggaaaaggca ttccagcggc tttatgcatg 481021 tccatgatta aatacgcaat ggactctttg ccggaaacgg gcatacaccc ttctcaagtg 481081 ctgaaaaatt tgaatcgtgt tgttgaacaa aacgttgatg ccagtatgtt tattacgatg 481141 ttttatgcga attacaatat ggacaagcat caatttacat atgcttcagc gggacatgaa 481201 ccgggattct attattctca aaaagacaac acgttttacg atttagaggc caaaggactc 481261 gttctcggca tctcgcagga ctatgactac aaacaattcg atcagcatct ggaaaagggc 481321 gatatgattg ttttattttc tgacggcgtc acagaatgca gaacggaaaa cggtttcttg 481381 gagcgtcctg atctgcagaa gctcattgag gaacatatgt gttcctctgc gcaggaaatg 481441 gtcaaaaaca tttatgacag cctcctcaaa ttgcaggatt ttcagcttca cgatgatttt 481501 acgttaattg ttttgcggag aaaggtttaa cgtctgtcag acgagggtat aaagcaacta 481561 gtgatttgaa ggaaaatttg aggtgatacg aatgaatata aatgttgatg tgaagcaaaa 481621 cgagaatgat atacaagtaa acattgcagg agaaattgat gtatactcag ccccggtgct 481681 tagagagaag ctcgttcctc tggcagaaca aggagctgac ttaagaattt gcctgaaaga 481741 tgtcagctac atggacagta ccggattggg cgtttttgta gggaccttta aaatggtgaa 481801 aaaacaaggt ggttcgctga aacttgaaaa tctttctgaa cggctgatcc gactgtttga 481861 cattacaggc ttgaaggaca tcattgatat ttctgcaaag tcagaaggtg gagtgcaatg 481921 aagaataatg ctgattacat cgaaatgaaa gtgccggccc aacctgaata tgtgggaatt 481981 ataagactga cgctgtcagg ggtcgcaagc agaatgggct atacgtacga tgaaattgaa 482041 gacttgaaaa tcgcagtcag tgaggcgtgc acaaatgcgg ttcagcacgc ttacaaagaa 482101 gataaaaatg gggaagtgtc aatacgattc ggtgtgtttg aagaccgttt agaggttatt 482161 gtggcggatg aaggagacag ctttgacttt gatcaaaagc agcaggatct agggccgtac 482221 acaccttcgc acacagttga tcaattatca gaaggagggc tcggtctata tttaatggaa 482281 acgctcatgg atgaagtcag agtgcaaaac cactccggcg tcaccgtagc gatgacaaag 482341 tatttaaatg gggagcgagt tgatcatgac acaaccatca aaaactacga aactaactaa 482401 agatgaagtc gatcggctca taagcgatta ccaaacaaag caagatgaac aagcgcagga 482461 aacgcttgtg cgggtgtata caaatctggt tgacatgctt gcgaaaaaat actcaaaagg 482521 caaaagcttc cacgaggatc tccgccaggt cggcatgatc gggctgctag gcgcgattaa 482581 gcgatacgat cctgttgtcg gcaaatcgtt tgaagctttt gcaatcccga caatcatcgg 482641 tgaaattaaa cgtttcctca gagataaaac atggagcgtt catgtgccga gacgaattaa 482701 agaactcggt ccaagaatca aaatggcggt tgatcagctg accactgaaa cacaaagatc 482761 gccgaaagtc gaagagattg ccgaattcct cgatgtttct gaagaagagg ttcttgaaac 482821 gatggaaatg ggcaaaagct atcaagcctt atccgttgac cacagcattg aagcggattc 482881 ggacggaagc actgtcacga ttcttgatat cgtcggatca caggaggacg gatatgagcg 482941 ggtcaaccag caattgatgc tgcaaagcgt gcttcatgtc ctttcagacc gtgagaaaca 483001 aatcatagac cttacgtata ttcaaaacaa aagccaaaaa gaaactgggg acattctcgg 483061 tatatctcaa atgcacgtct cgcgcttgca acgcaaagct gtgaagaagc tcagagaggc 483121 cttgattgaa gatccctcga tggagttaat gtaatgatcc aggttgaaga aaacgagcat 483181 attcaaactc tagtatatca actgaataaa gaagggaaat cgatttgcgg tgacagtttt 483241 tttatgaaag ctgatgataa ggagttaatt tgcgcggttg ctgacggact gggaagtgga 483301 tcacttgcta acgaatcctc tgcagccatc aaagacttag tggaaaacta tgcgagtgaa 483361 gacgtagaaa gcattatcga acgctgtaat caggcgatga aaaacaaaag aggcgctaca 483421 gcatctatcc tgaaaatcaa ttttgagcaa aggcagttta cgtactgctc tgtcggaaat 483481 gtacggttta ttctgcattc cccgtctggt gaaagctttt atcctctgcc gatttcgggc 483541 tatttatcag gcaagccgca aaaatacaaa acgcacaccg ccacctatga aaagggttca 483601 aagttcatta tacatacaga tggactcaac gtacctgata tccgctccca tttgaaaaaa 483661 ggccaatcgg tagaagaaat atcgaattcg ctgaaaatgt atacgacatc gagaaaagat 483721 gacctgacct atattctcgg acagctgtcc taaaaaacca gaaaaagaag ctggacatcc 483781 ggcttctttt ttttgcggtt gactattaat aagtgcgctt attatactta ataagtgaac 483841 ttatcattct gggagcttat gggatgtgga attatgaata cacagcgata gctgatgtgg 483901 atgtgggaaa acctggaact gttatcagga aacagaaaca atggatcaat gggagacggg 483961 tattgcatca gattctttga aaggacaatt tcaaaatgga acggaaggaa cattgcttct 484021 gcaaggaaaa acaattctct tatggcttga gcatgtggag aaacatcggg cgttttctgt 484081 catggtcaac atgcccgcat agcaatgtaa taatggagtt ttttcacgtg cttcaaaagc 484141 aaaaagaaga tttgtgtatc acatatggaa ttgtattaga aggcgctgaa gcaaaaaagt 484201 ggggagaaat cattgggact gaactgtcta aagacatgcc gacggctgtc agcaggcttg 484261 tccatcttta cggaggagtg ataaaatgaa cacaaattac tggatcggcg ttgtgtcaga 484321 gcaacatgta ttaaaaggcg ctgccggcgg ttttgcacag ctgtgccatg gaaaaaaagc 484381 cccgctcgcc aaaatgaaag agggagattg gctgatttat tattctccga gagacgcata 484441 tccagacggc aaactgctgc gaagctttac tgcgatcggc aaagtaaaaa gcggaaacat 484501 ctatccgtat caaatggctc cgaattttat tccataccga ttagatatag actattatcc 484561 atgccataaa atcggttttt acgacattaa atcaaagctt gaatttgttc aggaaaccaa 484621 gcatcttggc tttttatttc gcagaggaca ctttgaaata agcaaaaaag attttttgac 484681 aatagcacaa gcgatgggag ttaacataag tggaatggca ctctaaattt agcggtccga 484741 acacaagccc gggcttttta ttatggcagg ccacgcaaag ttggcagcgg aaagtaggaa 484801 aagcattggc tgagtttgac ctgacccacg ttcaatttgt tctgctgacc tcgtgcaagt 484861 atatgattgc tcacggagaa accgtcacgc aaaaaaaact tgcaagcttc agccagacca 484921 atatcatgat ggtttcggag gttgtgcgga cgcttgagaa aaaaggattt atcgaaagaa 484981 gcaaaaatcc ccaggataaa agagaggtcc tcctgtctct tacagaaata ggaggagaaa 485041 aagtaacagc ggctttgcca attgttgaga agattgatca agccttcttt gcagctgcga 485101 tgaaaaaaga gaattttctg agcggcttac aggaactatt gaaacatgag taaagatacg 485161 ggcagcgcca gctgtctttt tttatgtgtt tttttcggtt tttgatacac tagagaaaga 485221 acgacaaaat tggaggcttt ggttacatgg aaacgtcagc ccttttaaaa cagcaaattg 485281 cgaaagaaat aggtttatca caaaaacacg ttgaaagtgt catccgcctg cttgaggacg 485341 gcaatacagt cccgtttatt gcccggtatc gaaaagagca gacgggttca atggatgagg 485401 ttcagattca gacgatttct gaacgctggc aatacataca aaacctgaat cagcgaaaag 485461 aagaagtcat caggctgatt gcagagcagg ataaactgac agataatcta aaacgtaaaa 485521 tcgagcaatc ggtgaagctt caggaagtgg aagaccttta ccgcccttat aaacaaaaac 485581 gtaaaacaaa ggcgacagtc gccaaaagca aaggccttga gccgcttgcc gactatatcc 485641 tgacacttcc ccaagatgat catctggcag caactgcaga ccaatacatc agcgaagaaa 485701 aagaagtgtt cacacgagaa gaagcgattg aaggcgccaa gcacattatt gcggaacaaa 485761 tctcagacga gccgaccttc agaaagtgga ttcgccagga aaccttcaaa agaggaacca 485821 ttaagtctgc agccggaaag tcggcagaca ccgatgagaa aaatgtgtat gaaatgtatt 485881 acgagtatga agagccaatt gcaaaagttg ttccgcatag ggtgctggca atgaaccgcg 485941 gcgaaaaaga agacatttta aaggtagcga tcgaaccgcc tgcggatcac attaaggcgt 486001 atttagaaaa acaaatcatc aaaaatcgct caacatccgt aagagagatt ttgcaggaga 486061 caattgaaga cagctataaa aggctgatcc agccggcaat cgagcgtgaa atcaggaaag 486121 agctctcaga aaaagctgat gaacaggcga ttcatatttt ctcagagaac ttgagaaagc 486181 ttcttttgca gccgccgatg aaaggcaaaa ccgttctcgg tgttgaccca gcctttcgaa 486241 ctggctgtaa gctcgctgtg tcagatgaga ccggaaaagt cttgaaaatt gatgtgatct 486301 atccgcatgc gccagtcaac aaaacaaaag aagcccatga aaaagtgaaa aagattcttg 486361 agcagtatca agtcgagatg gtggcgatcg gaaacggcac agcatccaga gaaacagagc 486421 aattcatcgt caatgtactc agagacatgc cgcgcaaaat ttattatgtg atcgtcaatg 486481 aagcgggagc aagcgtctat tcggcttcag agcttgccag agaagaattc cctgacctta 486541 aggttgaaga gcgcagtgcc gtatctattg ctcggagact tcaagacccg ctcgcggagc 486601 tcgttaagat cgatccgaag tctgttggtg tcggacagta tcagcatgac gtcagccaaa 486661 aacgcttaaa tgaatctctg cggtttgtcg tcgaaactgt cgtaaaccag gttggagtaa 486721 acgtcaacac agcctccgcc gcgctgcttc aatatgtagc tggattatcg aagtctgtag 486781 caggcaacgt tgtcaaaaaa cgtgaggaaa tcggaaagtt ttcaaatcga aaagaactga 486841 aggacatccc aaggttaggt gcgaaaacct atgagcaatg tatcggtttc ttaagagtgc 486901 aggaagggac agagcctttg gatagaacag gcatccaccc ggaaagctat aaagaaacaa 486961 aagcactttt gaaaaaactc ggactttcaa cagaacatat cggcacggcg gaattgaagg 487021 acaaaatcaa tcagctggcg ctctctgaaa cggcaaaaga gctgggaatc ggcgaaatca 487081 ctctgaaaga catttgtgaa cagctgacaa ggccggaacg cgatccacgc gataaggtgc 487141 ctaagccttt gctgaaaaca gacgtccttc agctggaaga tttgaaagag ggaatggaac 487201 tgcagggcac cgtgcgcaat gtagtggact tcggagcgtt tgttgatatc ggagtcaaac 487261 aagacgggct tgtgcatatc tcaaaattga gcaatcaatt cgtcaagcat cctcttgatg 487321 tcgtatctgt cggcgatatt gtgacagttt gggttgacgg cgtagatgta caaaaaggca 487381 gagtatcgct gtctatggta aaataaaagc actgcttacg agcagtgttt tttcctatag 487441 aaataccagc attgattcag cagtttaatt tggtaattat ctttttcaag gaacgctttt 487501 tgcatctgct ttttaagcca atttggcata ggctcattcc tcctcagctt ttatcataag 487561 agggacagtg attaccatat tgtatgcgaa cggtgaattg tcccgttcaa tgttttttaa 487621 gtgaggtgca ccatggataa caaagagctt caaaagctga cagaggatat ttctgaaaca 487681 tattttaaaa agccgttccg ccatcaggcg ctttttaatg accggcttaa aaccactggc 487741 ggcaggtacc tgttaacctc ccataacatt gaattgaaca gaaaatattt gattgaacac 487801 ggcagggagg aactgattgg catcatcaag cacgagctct gccattatca tcttcatctt 487861 gaaggaaaag ggtacaagca cagagacaga gattttagaa tgctattgca gcaggtcaac 487921 gcgccgaggt tctgtacacc ccttaagaaa aaagcggaaa acaaaaaaac ttatatgtat 487981 atctgtacga cctgcggcca acagtatata aagaagcgcg ccatgaaccc tgacagatac 488041 agatgcggaa aatgccgcgg aaaaataaaa agaatttttt cgtgaaaaag gttgacgaat 488101 atggcaagcc tatgttacat tataaaagtc gtcacgagag ataaataaaa acatttacct 488161 cttgacactg caaatcaagg ctgatataat aagtcttgtc tcattattcc acagtagctc 488221 agtggtagag ctatcggctg ttaaccgatc ggtcgcaggt tcgaatcctg cctgtggagc 488281 catattggag aagtactcaa gtggctgaag aggcgcccct gctaagggtg taggtcgcgt 488341 aagcggcgcg agggttcaaa tccctccttc tccgccataa gatttcgata taagttctca 488401 accatcggcc cgttggtcaa gcggttaaga caccgccctt tcacggcggt aacacgggtt 488461 cgaatcccgt acgggtcatt ccatttcgtt gggctatagc caagcggtaa ggcaacggac 488521 tttgactccg tcatgcgttg gttcgaatcc agctagccca gccattttta tttttgaaat 488581 ctaatagtaa gagccattag ctcagttggt agagcatctg acttttaatc agagggtcga 488641 aggttcgagt ccttcatggc tcaccatttg tctttttgcg ggtgtggcgg aattggcaga 488701 cgcgctagac ttaggatcta gtgtcttacg acgtgggggt tcgagtccct tcacccgcac 488761 tttatttaca aagtgcacgc aaatctgttt tactaggtta agagcctact aaaccagcac 488821 aacacaattt aatgatcacg cggtcgtggc ggaatggcag acgcgctagg ttgagggcct 488881 agtgggtgaa taacccgtgg aggttcaagt cctctcggcc gcatctcaat aataccaagg 488941 gtttaaccac ctttggtatt atttttttgt gtggaaaata cggctatggg agaagacttg 489001 ctcaccaaaa ctcaccagtt acttaaagta agtcatccaa acggtcggcg gttccttctg 489061 tttattagga aaaagatatc cgttcattgt aaaagaaacg aaccatgtcc tattcgttca 489121 aaaaaactaa agggtgatac atattataca tgattaatat gtatcaccct tttctttctt 489181 gttcaacaat cgcgcttgag gagaacataa gctaatacaa ctgactcgat ttctaaagtt 489241 gctccattct ttttttaaac aactcatcca caacctgttt taaaatctcg tacgactgaa 489301 tttccttgct caattcgtaa atattagata acacaattaa ttcatctgcg tgatacattt 489361 gttggaaatc aattagttcg cgacgaattg tttctcgatc acccatgatt gtatacccca 489421 gtcgactgtg gagaatttct aattcaaact gtgataacga ttctaggaag ttttcagtgg 489481 gtggaataag cttacttaaa ttatttgtat aaatatcaat atacacctgc aaatgacttg 489541 cagaaataaa agatgcctcg tctatagatt ctgctgcaat cacattaatg caagcgatca 489601 cataaggttc ttgtaaataa gaagacggtt ggaaattttc tcgataaata gagagcgctt 489661 cttccatcga atggggtgaa aattgagcgc caaatgcata gggtaaacca agctttgcag 489721 caatttccgc tgaatccgtt gaggatccta acacaaaaac aggcacatgc gttccaatac 489781 ccggataagc gcgaacctca ccctgtacac tcttatcccc gacaaaacgc aaaatatcat 489841 ttacttctct ttcaaagaaa aacactccat tatggttgga acgacgaatc acatcggccg 489901 ttttttgatc cgttccgggt gcgcgtccta atgccaaatc tacacgattt ggatataatg 489961 tttcaagtgt tccaaattgc tccgctacga ttaatgggga atgatttggc aacataatac 490021 cccctgaacc tacgcgaatg tcttttgtat ttgctaatat atgttgtaca attgatacgg 490081 ttgctgcact tgcataagcg tcgtgattat gatgctctgc aaaccaaatc cgtttatagc 490141 ccatattatc tacagcttta gctaatgaca ctgcagaatc aatcccttgt ttcattgttt 490201 ctccttgtct taatggagca actgataaaa cagatatatc aaattttttc ataatttcac 490261 ctctaaaata atgaacttat acaagatcaa tggaaaaaac attttgaaaa attgtttcat 490321 attaaatggt gtccattcct ctttgatttg catgcaaata aatatatact ttctcaaacg 490381 atcaatacat aggcaaaata aagttatttc acaatttcac tttactttta aagttttaag 490441 caaacataaa aaaatgttca gtgaacaaaa tatgtaaaat acatcttatt tttcagaaag 490501 gatacaagaa aatgattgat gaaatagata aaaaaatact tgatgagctg tctaaaaata 490561 gtcgccttac aatgaaaaaa ttaggggaaa aagtacatct cactgcacca gcaaccgcat 490621 caagagtagt aaagttaata gacaatggca taataaaagg atgtagtatc gaagtgaatc 490681 aagtgaaatt aggcttctct atacatgctt ttcttaatat ttatatcgaa aaaatccatc 490741 atcaacccta tttagctttt atagaaacac aagataacta tgtaataaac aattataaag 490801 ttagtggaga cggttgctat ttgcttgaat gtaaatttcc ttcaaacgag gtattagatc 490861 aatttttaaa tgacttaaat aaacatgcaa actataaagt gtcgattgtt attggtaaat 490921 agttaacttt ataaaacgga gatgtgcggt catataacat gatatatatg ctctaaaaaa 490981 gccctaggtt ggatatggaa tttaccaagc tggggccttt ttatacatta taataacaag 491041 cgcattattc atcagacatt aatgaagtat tataatgctt ttttacttcc ttaatagaca 491101 aataaagctg atagtttcca tacttcaata aatcattcag aaggtgattt aaaacttctt 491161 gtgaatgaac cgttaccttc agaagataac atgcatctcc cgaaacacga tgagcttcgc 491221 taatttcatt acgagtagca ataaatttca ataaatcatc atgcatatat gcattcatga 491281 aaaagaagac aaaggctgta aaagaaaacc ccatcttcaa ttcatcaacc acaatcgaat 491341 atgctttaat gataccgtta tcctccattt ttttgatgcg attgcctacc gcttgtcctg 491401 tcatatgaat tttttcaccg atttctttcc attgtatccg agcattttta tttaataatt 491461 ggagaatttg aaaatcaatt gaatcaattt gcatagtaac tcctttcaca gtgaaaaagt 491521 tttacaaaat agtatttcat gagaccatcg aaaattcaat ggaaattata tatccttata 491581 cagtataaaa attttaagag gtgaaaaaat gacaacagct ttattagtga ttgatattca 491641 aaatgattac tttccaaatg ggaagatggc tttaacaaac ccagagaaag cagcacaaaa 491701 tgcggctaaa ctactttcac actttagaaa cacaggcgca cctgtctttc atgtacagca 491761 tatcacagaa ggtaacatcg ctcatttttt ccatccaaat acagaaggtg tcgaaattca 491821 tgagtcagta cgtccattag agaaagagac agtcattgta aaacatatgc cgaatagctt 491881 tttcaataca gatttaaatg gaaagctaca agaagaaggg gttaaagaat tagttgtttg 491941 cggtatgatg tcccatatgt gtattgatgc aacagttcgt tctgcagttg aacatggtta 492001 tgtatgccaa gtggtagaag atgcttgcgc aacaacaaca ttgcaaattg aagataaaat 492061 cgttcctgct gagcatgtcc attacgcatt tatggccgca ttaaatggtg tctatgcaac 492121 agtaaaaacc acagaggcat ttttaaaata aaagaatttc ctgcgcgaac ataacgtctt 492181 tcttttcaca agaaagatga ttcaacaact taaaaaagga tgttcagaaa aatacttctg 492241 gacatccttt attcattatc ttttattgtt tttcagtatc attattccca tctgataaaa 492301 gatcaagatg tcctgttttt gatccatagt aagaccatat acagggattg tttttgccat 492361 aaatatagat attgatgaag gtttacataa agcacctaat tgcttgattt actttaatgt 492421 tagatccctc aataactcca ttctcttcta atttctctac tctagctgta gctgctgggc 492481 atgttaaatg tactctctcc cagatctttc attgaattcg gctattatac ataatttctc 492541 tataattttt tatctgtttg atctatttga acgttaattc ctttcgaaaa taaagtcaaa 492601 gagttaaaac actttttttt atctatgtat tcgaacactg ctgatattat acacttaact 492661 ctgtcgatct aagacaaata aaaaaagaaa gtgagttgta aatatgaata ttacacaaat 492721 tcgaaatgca acaattgttg taaaatacgc aaataaaaaa tttttgatag atcctatgtt 492781 agcagagaaa ggtacgtacg ctactttccc tgaaacgatc agacaagatt tatttaatcc 492841 tttggtgagt ttgccaacat caattgataa cattctggat ggcgtagatg cggtaattgt 492901 tactcatcta cacctagatc actttgatga tgtggcaaaa aacgtattgc caaaaaacat 492961 caaaatgttt gttcaaaatg aagcagatgc aaaagaagta aaagcaagtg gtttcaaaaa 493021 tgtagaagtg ctacatcaag acactgtttt tgaagggatc caattagtaa aaacaaaagg 493081 tgaacatggc agaggggaag agttattaaa cttaatgggt gatgtttgtg gattagtatt 493141 caagcaccca agtgaaaaag ttttatatgt agctggggat acagtttggt atgatgctat 493201 cgaagacgag attcatacac atcaaccaga aatcattgtg gttaatggtg gagacaatca 493261 aagattagat ttaggttcac tcatcatggg aaaagaagac atctatgaag ttcacaaggc 493321 tgctcctcat gctaagatta tatctgttca tatggaagct gttaaccatt ggacactatc 493381 tagagaagaa ttaaaaaact ttagtaaaga aaaaggattc tcaagtaata ttttagtgcc 493441 agaagatggc gagtcttaca cattttaata tgaacaccga caaataaata gaagaagctc 493501 ataattataa aaactaatca tgagcttctt ctaataatga atattttaaa ttttaaatat 493561 atcgaaaatc ctaaatatac ggaataacaa aaatggaatg ttccaatgat gacaaaaaaa 493621 cttgaaaagc aacaaagatg tgtcgttagg aggtagaatt catggtaatg acaaaaaaag 493681 atacaaatat atcaacacag cagcctcttt ggttacaagg ttatattgat tcaccagaaa 493741 aacaaaacca actttataaa aaaacattaa aaatcttgat tttttcacaa atatttgggg 493801 gagcaggact tggagctggg ataacagttg gggcgcttct tgcacaagat atgataggat 493861 cggaaaatgt agcaggaatt ccaactgccc tctttacttt tggatctgcc gtagctgccc 493921 tgcttatagg agcatcctca caacgttttg gtcgcagagc tggacttgca ggtggtttcc 493981 ttataggcgg attaggtgct ataggtgtga taatcgcggc tttaattaac agcgttgccc 494041 tattatttgt ttctcttctt atttatggag caggtatggc ttctaatctt caagttcggt 494101 atgctgggac agaccttgca aatgagaaac aacgggcaac tgctgcaagt atggccttag 494161 tttctactac tttaggagct gtagtaggtc ctaacttagt taatacaatg ggggaatttg 494221 cagattcaat tggtgttccc aatttagctg gtccgtttat tatgtcagga gcagctttta 494281 taattgctgg aattattctc ttaatttttc ttcgtccaga tccgctgttt gtatcaacag 494341 ctattgcgaa tgctgagaaa aaagacgata aagtacaaat aggaggaagt ctaaaaaatc 494401 ctgctataga caaaaaagga ataatggtag gagctgtcat tatgatttta gctcaactaa 494461 tcatgacagc tattatgaca atgacaccgg ttcacatggg tcatcacggt catggtttaa 494521 gcgaagtggg attagttata ggactccata ttgcagcgat gtatcttcct tcaccattga 494581 ctggtttatt agtagataag tttggtcgca caactatggc tattgcttca ggtgccacac 494641 ttcttgccgc tgggttggtg gcagctattg caccggcaga ctcattatca ttgctaatcc 494701 tagcactagt attactaggg gtaggttgga actttggttt actaacggga actgccctta 494761 ttatagattc aacacatcca tctctacgtg caaaaacaca gggaacattc gatgttttat 494821 tagcactatc aggagcagca ggtggagcct tgtcaggaat ggttgttgca cattctagtt 494881 atacaatact atcaatttct ggagccgttt tatcattgtt actcattcca gtagttattt 494941 ggtattttag aaggattcag gaaaaagcat aagcttatat aactgtcttt gaagaaccta 495001 agtagacatt actttaccgg aacctccttt ttctatttat tatagtaagg agttgacatg 495061 gcattagtgg catgtgtata actacacaat tatttgggat tcagagagca tgtaatgaac 495121 ggaagagata attatttatc acttttatta ttgtacggtg ttcttgtggc attaagttca 495181 gtcaattttg gtctaactgt tttctttttg ttttcatcac ctctccatat tattaacaaa 495241 cacgaaaagg attttaatga aaataaaatg attagcgtat gtatctctaa ttttcaaaat 495301 gaatgaatag tcctttttaa gatttacaca cttattctcc aaggaaaaat gactcaattt 495361 ttcgattttt tatgtaaatc aaaaaagaat catgttagag taggtgtgct gaaaataatt 495421 caaaaaatta ttttgcgata tgattaaagt aatattgcca gagagtttca attggacaaa 495481 attgtaagtg tttaatacac tggggctgca atcaaatatg cacctggaat caattgctaa 495541 acgggggagt ttatatgaac aacaagaaaa atatctttga tattgttatg tacattattt 495601 tcggtgtgtt aagtcttttt ctagttgcaa aaactgatta tggcactgga gttttagtgt 495661 ttgttgcaat tttatacctc gctgttattg cttataaaat taagcaagta tttagtaatt 495721 cagattctta aggtgtaaca caaggaggat ttcaattgag aaagaaaaga gttattactt 495781 gtgttatggc tgcatcattg actttaggct cacttttacc tgcaggttac gcttctgcaa 495841 aggaggactc taagacaacc ccttcttacg aagaactagc tctacattac aaaatgaaaa 495901 gtgaaaagat ttcatcgaac gggaaattag ttgaaattga gtatgtgagt ggaaatgaaa 495961 ctcacaaagt tcagatgaac ggaaataatc atactgtaaa agtcgatggc atagaacaaa 496021 aaggtttaaa ctttgagtat gatgaaaatg ttgctaaaag aacaaattat gaaaacaata 496081 atttgaaatc aaatgaattc acaacacagg ctgcaaaacc taaaaaggga taccattatg 496141 tggggacttt atctgggcat acaaaagcag ctaaaaatgc gttatcagtt acaatgtcat 496201 tagtcggtat tgtccctggc ttgggatggg ggagtaaggc tgccactatt ttattctctt 496261 attgggcaaa agaacaaatc cctgatgcgt attataaata tgatttatac gaaaaaggag 496321 caatgactga tagttggtat cagtatgcta cagttcaatt ttttgaagat aaagctcata 496381 aaaagaaaat gggcaaacct tggacaagta ctcctgcaaa agtagattta cctaatagct 496441 aattttaaaa tcactttgtc tttataaagg acaaagtgat tttttgttat acagaagtaa 496501 aatccctcgt ctgaggaatc ttggaaaaaa cttggttcaa ttttgatata acatgttttt 496561 ttcttgctaa tttagttttt ctatgtatcg ctacacattc taaataataa gatattagcc 496621 ggacggttga tgccaagctc aaaagtttat atggaagtca aagcataaaa aagggtgtta 496681 caacgtgtag tcttcttttt attttgccaa cgtaacaagt gtgaaagtaa tgatttgtag 496741 gatcagttaa gaaaggttta agattagata ttgaaaaatt ttatatattt tcaataaaat 496801 actggtacta taataaatgt atacagattg tatggagatg taattaatta aaaaggagtt 496861 ttttaattgc gttggagtaa atggttcaat gttttttgta tagtagcatt gggatcaata 496921 tatggttata aattatttac taaccaagaa gtcagtacta ctcgtttaat aatagcttct 496981 gtaattgtgt tgtggaatat tgttggactt tttagcaaag aatcagtaaa acaagcacag 497041 caagcaaatt aaaagtcata aagttgggaa agaaggatgt tacttatgta gtatccttct 497101 ttattattcc ttgaaaaatg aaacaaattg gagattacag cttatataat caattgaagt 497161 cgttgattat tttcatgaac aggagattta atgctttctg atgaaatatt atcgtatgaa 497221 tgttgcaaga ggaaacgtta ctcaaagatt acagggatgt gatgaacact cctctttatc 497281 gcactcacct gaccccaaat tgttggggaa gggcaggtac ggaagataga gtattttttc 497341 ttcgtaacaa atcgaaaagg ttggataata aaaaacttat aatctaaggc ggtatatagt 497401 tgtgaaaaag gcgttatttc ttatattaga ccagtatgca gattgggaag gtgtttactt 497461 agcatctgca ttaaatcaaa gagaagattg gtcggttcac actgtttctt tagaccctat 497521 tgtaagctca ataggtggtt ttaaaacatc tgtcgattac ataatagggt tagaacctgc 497581 aaattttaat ttgctagtta tgattggcgg ggattcctgg agtaatgaca ataaaaaact 497641 attacatttt gtaaaaactg catttcaaaa aaacattcca atagcagcga tatgcggtgc 497701 agtggatttt ttggcgaaga atggtttgct gaataatcat agccatacag gtaattttgt 497761 ttacttatgg aaagattaca aacaatataa accgattagc agttttgtag agaaacaagc 497821 agtaagagat aaaaatttgg ttactgctaa tggaactgcc cctattgaat ttactaattt 497881 aattttagag atgattgatt ttgatactcc tgagaacata gagaaaatga tgtatatgaa 497941 tcgttatggt ttttatcatt tttgtgataa atatggaaat ccatttgttg attaatttgc 498001 tggaaatgat tttcccgaat agggggcttt gcgattgagt tgaatttcct aataaagcaa 498061 agaaagatga tttgaggtca agtttaacaa ataatgccat caatattaat ttgcagttat 498121 ttccgattcc tgatataata aagaagaatt atttttgttc ggtgtaaagg atagtatgaa 498181 gattgacttt tcgtcttgat gatactttgg gcaaggatag tatatactgt gtggttacac 498241 actaggaggc aacaaaaatg gaacaaggta cagttaaatg gtttaatgca gaaaaaggtt 498301 ttggctttat cgaacgcgaa aatggagacg atgtattcgt acacttttct gcaatccaaa 498361 gtgacggatt caaatcttta gacgaaggtc aaaaagtatc gtttgacgtt gagcaaggtg 498421 ctcgtggagc tcaagctgct aacgttcaaa aagcttaatc ttcaatcgtt tatacaaaca 498481 ggctctttat atagggcctg tttttttatg tctatatcat actcaataaa aaaccctact 498541 caacgttcga gtagggagat gctacaaggt aatagaaaaa gatttaaaac ttcaaaggtt 498601 tgtttacagt ataacatact ggattgacaa tatgcggaat gtatataaat tatttaatgt 498661 tttgttcaaa tatagataac tgactctttt tttcactaac ctgttcgttc atttaagtaa 498721 gattagatga attataaaaa tggtttcatc taaatgttat caactcgcat atctctttta 498781 tgagaagaag ataaacaatt attattcaat gttgcagtgg atataagaaa ttcttaaaaa 498841 taatgaggag atcgattgtt tttttctcct ggaaataatc acttagagat acctaaaaca 498901 atgaaagccc tacctctctt ccatccttac ggctccttgt ccgtgccagt gtgaatcagg 498961 atactaaaaa aagtgactat tttattgagt tttttggtaa aacttcaatc ttcgcagaag 499021 aaatgtaaat aataaaaatg gattagaatg taggaataac aaaagaggtc gttaatgttc 499081 taaacataag ttggagaaga tttgcttttc atcataatat tccgaaatat cttttgggat 499141 gtatctaacc aaaacttttt atttgttttt cagtgattcc tttaattact tccagttcac 499201 taatcaaaaa ttcatatgca ttatccagca tttttttttc gcttgcatta agtgcttttt 499261 ctttcttcat acgcattaaa tcacgtacaa cttcagcacc ttcttgtatt tcacctgttt 499321 ttattttgtc cgtgtttatt ttgtaccttt gcttccatgg cagtaaccta tcggattctc 499381 catgctgaaa aatgtgcata atgtgtttta atgcaagtat atcggtaact ggtcgtatat 499441 tcgaactcaa tattttactc gttggaatca taactgtcat attactgatt gacattctta 499501 tgacataata ctgttgtttt tcctctaaga attctttttc ttctatggct tcaattatac 499561 ctgctccgtg cattggataa acaatgttat cgccaatttg aaacatatca tccacctcca 499621 tatatggtat ccttcttaag attaccatat atggaggtgt aatatcaaaa ttttaataat 499681 aacatgatcg aatttttgat gtcaataact tttttgaaaa aacagatcaa gcaaaaacaa 499741 tagggaacgt gtcggatttc caatcaggaa aaggtcaatt gatccgtgtg agcagttttt 499801 cattggctca atgacattac agaaatgatt tgagtagata agaaagaacg atattcgtga 499861 aatgtcagct aaaaatattt aaagcacatg attaagttct aatttcttta ccgatttgat 499921 atggataacg gccgacttac ttaatgatgc attttcactt atcttgcaag cagaaaaagg 499981 tttgttgata aacatttagc caccaaattg gcattattat cagggaaatt gacaaccttc 500041 aaatgggtat tgaggcgaga agaaaaataa agaaaggaga gattataaat gaagaccaga 500101 acataaagaa gtaaagggga aagaacaagg ttaattgaaa agcaaactat ataaaatagt 500161 ttgctttttt ttgttatgac ttcacttctt tttctttctc tttaatgact aataaaacac 500221 cgctcagaat taaaaacgaa cctatccaaa atgtcccgcc tatttgttct ccaagcagaa 500281 tccatccgag taaggttcca accagaggct gaaaaaagaa aaagaggcct ccacttgagg 500341 catttaataa ttgtaagccg tggttccaca ataaaaatgc acaagctgtt gaaacaattc 500401 ccaaatacaa aaggccacct agaattttag ggtcaagcag tagtggcgta aaaatcgtgc 500461 taggggagta ccattaacag ggactccatt tattaataga ataaacttta tgaattcatt 500521 tttttgtatg ataatggcgt catattcatc gcttgttgaa atttacttat gaaataactg 500581 gtactgttaa atccaacttg ataagacact tctgtcacat tggattcagg gtgttgcagt 500641 aataataagc ttttttgaat tctataatcc attacataac gtaatggcgt cttattcagc 500701 attcgtttaa aataacggca gcattcagaa cggctcagtt ggccagcttt tgcaatgtcc 500761 tctaatgtga ttttttcaac ataatggaga tggatccagt ttaacatttg tttcattcga 500821 tgacttttta tcatttcaga ttgatcgtac tctaattgaa aaccattaac gaccaggttt 500881 ttccacatta acgttaattg catcgtaatg tcaatctcat agagcgatgt cttttgttga 500941 atcaattgat ttattttttt aacagcatct agaatatttt ttgcccactg ttgatttcca 501001 gccaaaaata aatagggcaa attggttgaa aacatatagg gctgaacata gcttgaatac 501061 agttcctgag ataaaacgaa atggggtgac acattcaagc aaatatacgt acaatccgag 501121 ccttcctttt cttcggccat gtgcaggtag ccgctattga taaataatcc atccccttcg 501181 tgaacctcta ttttttcttc atttatttga aagagagcta tcccttttag tatcaaaaca 501241 aattggattt catcatgcca atgaagcgga atatagccat ttatattttg attgatcgtt 501301 gtcttgtagc aggcaactgg caattctacc gttcggtgct ctgttaattc ttttaaattt 501361 tgatcgatca caaaattctt cattctgact tcacacctca atatatttat attttttcat 501421 tcaatttgag tattttttat catgttttgc atttattata acactattat tatatttatt 501481 agtgaggagt catgtatgaa tacttccaat agaagaatgg gattgttcta tgttatcaca 501541 ggggcgacat gttgggggat tggaggcaca gtagccaaaa aactttttca agaatatcaa 501601 attgatgtca attggcttgt aacgacacgc ttgcttacgg ctggaatgtt acttttaatg 501661 ctgcaactgt tcagaaagga tcgttcccag gttattgagg tgtggaaaca caaagcgtcg 501721 gctggccagc ttctaatttt tggcctattg ggaatgctag ctgtgcagta cacatatatg 501781 gcatccattc aacatgggaa tgctgccgtt gctacgttat tgcaatattt atccccagta 501841 atcgtcatta tctacacgct gttgcgaaaa caaacggttc ttaccaaaca agatatcata 501901 actgttgtac ttgctttagt gggttgcttt tttttgttaa caaatggttc aatgtctcaa 501961 ctttcagtgc cggcagctgc agtagtatgg ggagttttat caggattcgc ggcagctttt 502021 tatactttgt atgccgttgg tttattaaat aaatttgatt ctcttgtcgt tgtaggttgg 502081 gctatgatta ttggcggttt tgcattgggt tttatccatc cgccatggca actggatttt 502141 caacgattaa ctgctgaggc gtatgcatat atcttattcg tgatattatt tggaacaatg 502201 attgcgttct ggttcttcat aaaaagcttg gaaagcctct ctccaaaaga aacaagccta 502261 ctaggcagtc tagagcctct atcagctgtt gtaacaactg tcgtttggtt aaaagcgcca 502321 tttggttctt ttcaatggat tggtgctatt tgtattatag ggataacttt aatattggct 502381 ttacataaag agccttctat ggagagtgaa aaatcgatat taaagattag gaatcatgca 502441 aatcgggata tataggggct ttttttgctt acatgaccgg tccggcaatg aaaaacactg 502501 gtggagtttg agccctctcg gcagtatcaa aaataccaag ggttttgacg ccctaggtat 502561 tttttcttca agaaccttca atttttcttc tctgattgaa aaacgtatta cttttttgtg 502621 attggtatcc aaatttcact tttaaaagat ggtgatgtta catccttatg ctcgttccac 502681 aatatttctg gaccttctat ttgttcgtaa tttgacgatg gaaaccattc ggaataaatg 502741 cgtccccata cttcttgcag tgtatccgga aatggcccga ttgattcgaa tacagcccat 502801 gttgaggcag gaacttcaag ccgtgagaag ttatctggac accgtttcgt tgtggctgcg 502861 ccaatatagt gatcgagctc tccgttttcc tctgtccgac cttcagaaaa attcgtggat 502921 gcactaatga ggcctgatgg tgctacatta gatagctctt ttagtttatt tattgctttt 502981 tcatctaaac tttcccacat agatgcaatt tccggattaa ttcctttgaa aataatagga 503041 actctttttt taatgccaac gatgcgaaat gcctcttttt cttcaatacg gtagttcatt 503101 tcatttcctc ctttaattgt tagctggaag gtcattcgtg gataagcttt aagggaatgg 503161 ccattaaatc tggcttttga tgggtttatg ccatgtaaat tttggaatgc ccgtgcaaaa 503221 gaatctggtg agttataacc gtactttatt gcaatatcaa tcacttttac attgctgtct 503281 ttcagttcaa aagctgcaag agtaagacgt ctgcgacgaa tatattccga taatgaaata 503341 cctgcaagga aggaaaacat ccttttaaaa tgatattcag agcagaaagc aagctttgct 503401 gcctcttgaa aatcaatatc attagtgagg ttttcttcaa tatactttaa cgccctattc 503461 atacttttaa gcaaatccat ttatttggcc tcctttaacc aaagaataac aggagtgaaa 503521 tgtatttatc cgacattctg tgcacagttt tgcaggatga cttatatgaa ataaagtaag 503581 tgattcactt gtatttgtac aggttttatt gaagcatgct gttcataaaa aggcatcaat 503641 aaaagaaagt tataattgtc ttataaacgg cacattcata taattgagtg aaaaaggatg 503701 cgtatcatgc ctatcaattc ttttgaaaat tatccgatga gctggaagcc atcgattgat 503761 aaagctgaaa agcctattta taaagcactt gcagggcaat tggaacagga tattttaaac 503821 ggagttttat tacctggaac aaaacttcct ccacagcgag aattggccga ttatctagat 503881 ttaaatgtga gtacgatttc aaaagcattt aaagtgtgtg agttaaaagg gctgctgagt 503941 gcgactgtag ggagcggcac atttgtatcg tatgatgcgt tgtcgaatgc gtatttactt 504001 gaggatacta agccgacaca tttaattgaa atgggagcaa tacttccaga tcacgcttca 504061 tatgagccct tgttatacca actgaaaaac atggttcatg aggaggatta tgaaaaatgg 504121 tttagctatg gccgggcagg tgaaagcctt tggcaaaaag atgcagctgt aaagctcatc 504181 caaagaggcg gatttgaaac atccgttgat cacattttat ttgcaaatgg agggcaaaat 504241 gcgattgcag cgacattggc gagtctttgt aagcctggag atcgcatcgg agttgaccat 504301 catacgtacc ctggattaaa aactgttgca tcattgctta gtgtgcaaat cgtaccgata 504361 aaatcagaaa acgatgaaat gagtccggag tcacttgaat atgcgtgtaa aaacgaaaat 504421 attaaaggtt tgtatttaat cccggattat cataatccga cgacttcctt tatgtctgtt 504481 gagaatcgaa gaatggttgc agacattgta aagaaatata atctgtttgt tattgaggat 504541 gcatcgtacc atcttctcaa caaaaatccg cttccggcac tcgcctcatt cgcaccgcaa 504601 caggttattc atattgcaag tttatcaaaa tcgttagcgc caggcctgcg tttggcttat 504661 gtagcagtgc cgagacaata taaggagcca atatcaaagg cgctttataa tttaaatata 504721 actgtttccc cgctattagc tgaacttact gctcgcacga ttgtatcaaa tcaatttgaa 504781 gtcttaattg agagtcatcg tgaacaaacc attcgcagaa atcaactcgt aaaccgatat 504841 gttgcgggat atacatgttt aggtgttgaa acaggcattt ttcgttggtt gttgttaccg 504901 ggtaaaatgt ctggtgccga atttgaagaa ttggctgctc gacttggcgt gcaagtgtat 504961 gcggctgaac gctttgtagt gggaaatagt tgtcctgaaa gggctgtaag ggtttctgtc 505021 tgtgcaccaa aaacacttga agagcttgaa caaggattaa tgatcctgag acgtttgcta 505081 gacgatctta cctaatattg tttgccatac aattatgaca ttgtatggct tttttgtgcg 505141 tgttatgatg atccacatct agagggaggt ttatacaaaa ttggctttta gaaaggaagg 505201 tcagatgatg ttagacaagg acagcgtaaa agcaatagat gttcaaactg cttcattaca 505261 gagctacatc agttcaccag aaaaacaaaa atcgttatac aagcgtacac tattcgttgt 505321 gagtatctca caaatttttg gcggtgcggg gctggcggca ggagtgactg tcggtgcgct 505381 tattgcacag caaatgcttg gcactgatgc gtttgctggt ttgccttctg ctttatttac 505441 tttagggtca gcaggatctg cattaattgt tggaagactt tctcaacgtt atggccgtcg 505501 aacaggtctt tcagctggct ttatgattgg cggacttgga gcaataggcg ttattatggc 505561 agcaatcata aatagtattt tcttgttatt tatttcgttg cttatttacg gtgcaggtac 505621 agccactaat ttacaggccc gttatgcagg tacagactta gcaaatcata agcagcgagc 505681 gactgctgtt agtataacca tggtttttac tacatttggc gcagtggcag gtccaagctt 505741 agtgaatgtg atgggggatt tcgctctttc tattggtgtt ccatcacttg ctggcccttt 505801 cattttagcc gcagcagcat atatgttagc aggtgtggtc cttttcatta tgcttcgtcc 505861 agatccatta gttatagcaa gaacaataga agcggcaaat gaagagcctg gtgataaagg 505921 acatttggcg gcaactgagc atacagaaaa caaaaaaggg ataatcgttg gggcaacggt 505981 tatggttctt acccaaatag taatggtagc tattatgaca atgacaccgg ttcatatgag 506041 acatcatggg catgacttgg gtgcagtcgg tcttgttatt ggttttcata taggtgctat 506101 gtatctccct tcacttgtta caggtgttct tgtagatagg ttgggacgta ccgcaatggc 506161 tatttcctct ggaacaacgt tgcttttggc aggtgtaata gcagcatttg ctccgggaga 506221 atctatgatt cttctcgtca ttgctctttc tttactggga ttagggtgga attttggttt 506281 gataagcggg actgccctta ttgtagattc aactgatact gccacacgag ctaaaacgca 506341 ggggacagtg gatgttctga ttgcgttgtc aggagctgct ggcggagcat tatctggaat 506401 gattgtggca ggttcaagtt acctcgcatt atcacttatt ggagggattt tgtccttatt 506461 actcattccg gtggtggtat ggtctagggg ccgctaaagg gtaggattgt ttaatttaca 506521 ttaatttgtt atattgttag ataaagtata ttgcagcatc taatattcta acgaactata 506581 gttgctccat taaatctatt ataaagattt gaccaggatt ccttatagct gtgtcactca 506641 ctgcatattc tttaattgaa tcacataaaa tggttatcgg atttgaaaaa ggcaggatta 506701 ctcgctttag gtaaaggagt cataacgttg ttaaaaaggt tttctcttgt tattgttaca 506761 ctaatgatgt ctatcgttgt tgttttagcg gctgctaaag agtcgcctgg agatcatgtc 506821 atctcatttg atgaacctat tatcttgatg atctcaattg gaatcgttgt atttttattg 506881 atccctccat tagtcatgtc cttttttggc aatttggttg taagaataat atctggtgta 506941 taccaatgtt ttatcgtttt cacttttctg gggctcattc caattggatt tcttattccc 507001 aatggctttt tgacaattct agtttctatt gcaggaactt tagtcagtat agctagtgtt 507061 gccgtaacct tatgcattgg caagaataaa aaagatatat aatcatcgaa ttgttatttt 507121 ttcagattgt cagtgaaata attatacaaa aagagaaggc ttgtgggcct tctttttttg 507181 ttgttgcatc atccccactt tgagcttaat ctattgaata ataagagaag gaacctatag 507241 aagaataaaa taaataccga gatgtcaaaa ataaaactgg acttcattat tgtgaattca 507301 cgtaaatgta aaaagattgg aaagagggga attccttcat gacaaatagc agaacaaatc 507361 cgaaggttga tgaattttta agtaaagcga aaaagtggaa ggaagaattt gagaagttga 507421 gaaccatcat tcttgactgt gagctgactg aagattttaa gtggatgcat ccttgttaca 507481 catatcataa taaaaatatt gttttaatac atgggtttaa agaatattgc gcgcttctgt 507541 tccacaaagg cgtcttatta caggatacag atggaattct cattcaacaa acggagaatg 507601 tacaggcggc gcgccagatt cggtttacaa atgttcagga aataaatgag ctagaaaaca 507661 ttttgaaagc ctatattcac gaagccattg aagttgaaaa agccggtttg aaagtggatg 507721 ttaacaaaaa tattgaattg aacattcctg aagaacttca aaataaattc gatgaaatcc 507781 ctgcattgaa aattgctttt gaagctttga ccccgggacg gcaaagagcg tacactcttt 507841 atttttctca agccaaacaa tccaaaaccc gagaatcgag agtcgaaaaa tatgtgcaaa 507901 aaattctcga tggaaaggga ttaaaggatt aggcacgcca aggttcaggc taaaggaata 507961 gcatcatagc gtaataagat catttctata gaagaaaaac aagcatagta agatgcttgt 508021 tttttcttag gacaacattc acttactgct gaaatgcttc taacattgta tgccactaga 508081 cagcgttata aaatattaat gcaacaccta gaaatctatc caatgaaata gctcaatggt 508141 atggctcatt acatttagaa tgcctaggag aactaataga accggaagat ttttagcaag 508201 ttactacact ccaaactttg tttttgtatt aatatacctt attaaccatt gtttttagtc 508261 aggtgcagac aaacgaatac tgattaatga atcatcatga tatcaatgag ccgcttgatt 508321 ttttcatcgt cgcctgtatc aacgtacact gtttttctgt tttttatgat actctcagtc 508381 acttcccgca tgacgccttt ttctatatca tcagcggaat cccagcgtaa aggcacatta 508441 tatacatgaa ttgtgccatc cccattgcca tgataagtga ctgatccatc cactaaacga 508501 gaacctgcca actgggtcac attttctgga tagctggcac ttgtatcatc attaggatta 508561 attggctcgc cagccgcaat atgtcgaaca tttaattcat ctatctcttg attaggtcca 508621 agttgaagcc aaactctggc atattcaatt ttttccgaag agtatgctgc caatacattg 508681 tcttctttgc ttttctcttc tgctgaagag gtatcatttg cagcttttgt tgcggattct 508741 tctgattctg ttattggctc cgcttcatcc ttgcgtattt tggtgctctc ttcaggctca 508801 gtgtgttttt cgtcagtttg cacagcagaa gcttgatttg aaggttgttg tgcttctcca 508861 tccttactgt ccgtacatcc agcaagcaaa atcataagca gcagggcagt attgcaataa 508921 catatctttc tgcgtttctt cattttttca ttcctctcta ttaattcagg tcagcttcat 508981 atataagttt atgtatctaa atattaccat ggaatagata ggatgatatt gaaaactgtt 509041 taagaagagg aaacgatctt gaatagcatc gcgaaaacct aagaatctta agaagttttg 509101 cccctttttc ttcaggtatt gaatgtaaag tgggatataa atgcaaacaa aaacgaaatg 509161 ccttatccac ctcgtgtcat ggcagaaaaa gtgggggatt tattagagcg gatttgataa 509221 tggcggcagg taaatgggtg ttgacttata tgtctaagcg ggagactcaa gtctgctcga 509281 tcgcatacaa aataccaagg gccagcaacc cttggtattt ttataccttc atgcattttt 509341 gaagtttatg cttaaaggtc tgccttactt tgcaaatcgc cgagctgctg caacgcacat 509401 gataacggcg atattcactg ctacgagtgc ccagcccact ttctcgtgca gaatcactga 509461 ggcaagcagc agtccaaaaa aaggctggag aagctggagc tgcccaaccg ctgcaattcc 509521 cccttgggca agacctcgat accagaacac gaagccaatc agcatgctga ataaggatac 509581 atatgcaaga ctgagcagtg cgggaacgcc gatcgccgac catgagtccg gcgtaaaaaa 509641 gaacgacaat ggcagcataa gaggaagcga cagaacgagt gcccatgaga tcacctgcca 509701 attccccaga cgccgtgaaa gtttggcccc ttctgcataa ccaagaccgc atacgacaat 509761 agaagccagc atgtacgcgt cgccaagcgg ggatgaacct cccccctgaa tgagggcgaa 509821 acctgctact aacaagctgc cggcagctga gaaaatccag aagacggggc gagggcgttc 509881 acccccgcgc agtacgccga agactgccgt tgcgagtgga agaagtccaa tgaagacaat 509941 ggcgtgtgcg gatgtgacat gctgaagcgc taaagctgtc agcaacggga aaccaatcac 510001 tacgccgaac gctaccacta acaatgaaat gagatctctt ttggcaggat gctgctgccg 510061 gaagatgaga aggagacctc ccgccagtac accagctatc gcagcacggc aaactgtgag 510121 aaataacgga tcgaagtctg acacagccaa acgggtcgca ggcagcgagc cgctgaaaat 510181 gagtacgcct ataaaaccat ttatccagcc atttgttgtt ttgttcatta taatcactcc 510241 acatatcttt cttgttcatt gtctgtattt tcttaacaaa accagcagct aaggattaca 510301 atgactataa actggaattg gccttttata aacagccagt tttcataaaa aaatgcatac 510361 cagttaggag aacaacgcgc aaatggatat cacgcctttt ttgaatagaa ctctggatat 510421 tccgctttat cagcagcttt atcggtattt taaagaaaat atgcatcggg gccgtattca 510481 aaaaggaatg aagcttcctt caaaaagact cctggcgaat cagctttcca tcagccaaac 510541 gactgtagaa cgtgcctatg aacagctcgc tgctgaaggt tatattgtga gcaagccaag 510601 aagcgggtgg tttgctgatt atcatgattc tgattttgct tatgatagaa tgccaagcac 510661 aacacccatt caacaagaag cagaagaaaa taaacaatgg attgattttc attatgggaa 510721 tgtagattct tcttacttcc ctttttccgc atggcgaaaa agcatggtca atagcttaga 510781 ccaatatgga cacgagcttt atcggccggg acatgtttta ggagagtttg agctgagaac 510841 actcattgca gagtacctgt atcaatctcg gggggttcat tgcggccctg aacaagtgat 510901 tataggtgcc gggaacccta ttctgctgca aatcttgtgc caagtttttg agccgaatat 510961 ttctataggg tatgaggatc ctggttatcc aagagcacgc aagatttttg aagccaaccg 511021 catgaatatt gttcctatac cagtcgatga tgagggaatc tgtatacaga agatcaaaga 511081 acagcagcca aaccttgtat atgtcacacc ttcccatcaa tttacgctgg gaaccataat 511141 gacaataaac agaagaattc agctgctcaa atgggcggcc gaaaatcaat cctttatcat 511201 agaggatgat tatgacgggg aatttaggta cacaggacag ccggttcctt ctctgcaagg 511261 gcttgatcag cataaccgtg tcatttatat gggcactttt tctaagtctc ttttgccctc 511321 gctgcgtatc agctatatga ttcttccttc gcctctttta aaaaagggtc atgaaatcac 511381 gtccttatat aagcagacag tgtcctgcca cagtcagcta accctagctg aatttataaa 511441 aaatggagag tggcaaaaac acatcaacag aatgagaaaa ctttaccgca aaaaaagagc 511501 cattgtatta gaggcagtgc aaagggaatt aggagagcat gtcagaatcc gcggagaaaa 511561 ctctgggctt cgtatcttac ttgacgttta tttgccattt ggtgaaaaag agttaattga 511621 gaaggcgaaa aaacatggag taaaaattta tcctgtttct ctttcttatc aacatcatcc 511681 tcctacaaaa acggtctcgc tcgggtttgc aggggtttct gaatccgaca taagagaagg 511741 cataaaaaaa ctgaaggctg cctggaagat atgagggagc tttcagttta gcaaaacggc 511801 caagtgacga ctaagtgttg agagctgttc aatatttttt aagtatatga tgagtgcctg 511861 cagtccaggc cacgatacgt ctgtttagcg aaaaacagaa ttttttattt gctcctcaca 511921 gtgctaaaat aaacaaaata gacaattgaa aaaatagagg tgtaagaatg aagttagatg 511981 agtttacaat tggccaggtc ttcaaaacga aatcattaaa agtatcaaaa gatgatatta 512041 tgcggtttgc gggtgaattt gaccctcagt atatgcatgt agatgaagaa aaagcgagta 512101 aaggcagatt taatggaatt atcgcttccg gcatacaaac actggccata tcttttaaac 512161 tttggattga agaaggtttc tatggagacg atattatagc cggaacagag atgaatcata 512221 tgacattcat aaaacccgta tatccggatg atgaattgtt tacaattgtt gaggttcttg 512281 ataagcagcc aaagagaaat gaattgggaa tactcacagt attgctatct acttataatc 512341 aaaaagaagt aaaagtgttt gaaggtgagt tatctgtatt gatcaaacga taactcagaa 512401 agcccgcttt tcgcgggctc gattgaagca gatgggtgaa agatgttagc gggtttcctt 512461 tgaaaaataa gaggttaaaa catcataaac aataggcaaa gaagtaaatc cctcatcttc 512521 tagaaaatga cctccgtgct gaacttcata taacgcagca tcaatttgtt gtgccagatc 512581 cttgctgaat gaaaaaggca caatttggtc gtccttagaa gcaatgacag cacggtgctt 512641 cgcggactcg atgatttttt gatgatcaaa cgatccctgt gtaaattcat ctaacatctg 512701 taaagtgggc aatgatttgg caaagccgga aacaagtatg attccgccaa gctgttttcg 512761 taattgaaga tgttccaaaa atctcaaaat ggcggggcaa cctaagctgt gcgcaaccaa 512821 atacgtattt tcatgtaaag tgtgctgata taaagagagt gtatccagcc aatcctcaag 512881 tcttggctgg agcggattag gcatgtttaa aatgtctgct tggaccccat ctgcgagcag 512941 acgttttttc agccaaggga accaatgatt tgttgaggag gctctgtagc catgaatgat 513001 atagacttgt tttgtcatta tttcctccta agaaatattt tcattcagta taaaattcct 513061 ctcattggga aacaagtacg cacttttttg taagtagctt tacatatgag gccctccttg 513121 tgccattccc cacttacaca tctcatctat gaggggatac aaagatcgcc ctctgtcaga 513181 taacgaatac tctactttca gtggggtgtg agaaacctca gaccgatgaa taaggccgtc 513241 agtttgcaat tccttaagct gtgcgcttaa cattttatgg gtgatgaagg gcatagccct 513301 tttcagctcg ccgtatctca tcgttttttc acaccctaac tcatagagaa ttctcatttt 513361 ccatttgccc cctataagag ataaggtgta ttcaaatggg gcttgtttac tgcggcacag 513421 gctattcatt gtaatcaaac ctcctttttt aagtatcata tcagaataaa ttaggatttt 513481 cggtgttgaa gtttgagggc gattcacgat ctgaagtgaa aggggccgct tgctcaacag 513541 gcggcacggt acatgaatgt tctaagtcaa agagggttac cttactgtta gttactttat 513601 ttaaaaaaac gcatgttttt agctgaaaat atctattatg gtatatttaa atataaagaa 513661 atatttgaga aatgaggaat ggtatgaata cacccaaaaa acataagaaa tttaaagcga 513721 aaatgattct ccaaatcatc atggttatca ttggaggaat catagcggca tatggactag 513781 aaacagtgct cattccaaac agtgtatctg atggaggggt gacgggtctt agcatcgttg 513841 gttcacagct attcaacttg ccgctgggga ttttgattgc tgtgatcaac attccatttg 513901 tctggttagg atataagcaa attgggaaaa gctttgcatt attatcaatt atcggaatcg 513961 tatcgcttgc cgcggggaca agctttttcc accacacacc cgctatcata gaaggagata 514021 ccctgttaat taccgttgtc ggcgggatta tccttggatt cggaatgggg ctggcgctgc 514081 gtaatggcgg cgcattagat ggaattgaca tgcttgctgt gctgctatcc cgaaaactgc 514141 cattcggaac gagcgatctc attctattct taaacctatt tgtgtttatt tttgtttcca 514201 cagtatttgg cttacaaggg gcattgcttt cagtcattgc ttactacatt gcatccaaag 514261 tgattcatgt tgtggaggaa ggcttaagcg gctctaaaac ctttcaaatt attacaaccc 514321 aacctgaatt aatggtagag acaatacgtg atcaattagg ccgaagcgcc acatataaag 514381 aagcttacgg gggtttttcc cacgagaaat ttaaagaaat cacatgtgtc atcaaccgtt 514441 tagaagaaac caaactaaag gaaattatta atgatattga taaaactgcc tttgttaccg 514501 tgtatgatgt agctgaagtg aagggcagca attttagaaa tcttaatcat cactaaaaaa 514561 tagaatgacc tttttaaccg taactgacat gccgcgggta atttaatcaa aaacactttt 514621 ttgaggcttg tgggtgaata accggtgaag gtctgaatca cagaaatacc aagggcgtca 514681 aaacccttgg tattttttct ggttattaga ttttatcttc agctttacgt gctgcttcga 514741 gcttatcaat cctgtcttta tatttttctc cccagtcctt catgtgcagg ataacaggtt 514801 ctaatgttct tccaaactca gttaaagagt attcgacttt tggagggacc tgtttataaa 514861 cctcgcggtg aatcacgcca tcccgttcca attctcttaa ttgtagcgtg agcatacgct 514921 gggtaatttt tgggtatagt tttcgaaact cattaaacct ctttttaccg tcaatgagat 514981 gataaagaag aatgcctttc cacttacctc cgatgatatc taatgttgtc tccaccggac 515041 atccttcaaa gtcatcagaa gaataatcaa tgccgagttt acgatttctc aagctgttca 515101 ctcctaatag tatacttttt gatactatat acattcaatg tgcgtacttt ttatatttta 515161 atatacatca tataatgatg tcacatctaa ggaatgaaag gaatggatca tatgaaaaca 515221 ctcgtactcg ttgtacatcc gaatatagaa tcctctcgta tcaataaaaa gtggaaagaa 515281 gccgttttaa gtgaaccaga tgtaactgtc catgatcttt atgaaaaata tcgcgatcaa 515341 ccaattgatg tggaatttga acaacagcag ctcctggccc atgaccgtat cgtttttcag 515401 tttccattat actggtacag cagcccaccg cttttaaaac agtggtttga tgaagtgttt 515461 acgtttggct gggctcatgg tcccggcgga aataaattga aggggaaaga gtgggtaact 515521 gccatgtcca tcggttcacc tgaacactct tatcaagccg gcggatataa cttgttttcg 515581 ataagcgagc tgacaaaacc gttccaagca tctgcccatt tagtaggcat gacctatctg 515641 ccttcctttg ccgaatatcg cgccaataca atcagtgacc aagaaattgc cgaaagtgcg 515701 aatcggtatg taaagcatat tacaaatata gaattaaacc cgaaggttcg cctgcaaagg 515761 tatttgaaac agctggagag tgtcgattta acataaagat tgatttttga aaatcctgta 515821 ctcaccaagc aggatttttt cttgttcagc agagggattt taacatatag caaaaaaaga 515881 agaagccacc aaaaataagc tatttgcttg gtcctgactg cttatttttg gtgaaatact 515941 tatttctctg tgatgaaata aagcaaagcg atgaccggaa aagcgattcc aatccataat 516001 gctgtactcc atccgcctga ggcatatgcc catcctccaa ttgatgaccc tatcgcaccg 516061 cctagaaaga agatcgccat gaataatccg tttaatcgac tgcgaatttc aggcgccaac 516121 gaaaaaatag cacgttgact gagcacaagg tttgcagata cacccatatc taacagaata 516181 gcagcggcca ctagaactgt tataccgacg ggggagctgc tctgaatcat gagcggcagt 516241 aataaagaga caacgacaac accgagagcg attccagtgg caagcctggt taagcctcga 516301 tcagccaggc ggccgcctat tggtgcagtg actgcacccg caatgcccac caatgcgtag 516361 agtgctattg ccttctgaga aaaatgaaaa tcaggaccgg acaataataa aggaacagtt 516421 gtccagaaca agctgaaagc tccaaataca aacgcatgat agatggcacg gcggcgtaag 516481 actggagtcg tgcgcagcag cttccacatt gaaccgagta aggcagtata gtttgtattt 516541 gctgttggtt ttctggcagg aagcactttt gataatacga tggccaggat aacacttacc 516601 acggcggaca aagcgaatat tgcattccac ccccagatat cagcgactag actagatatc 516661 ggacgggaaa gcataatacc gagtaataag ccgctcatga cattgccaac aacccggccg 516721 cgtgcagcgt ctgatgcaag gtatgatgca aatggaacaa gcacttgggc tgcgattgat 516781 cccaatccga cgaaaaacgc agctgctaaa aacagtgttc catgcttcac aaatgctgtt 516841 agtgtcaaag ccgctgcgct tagaaggagc gatacaacaa taagtttttt gttttcgata 516901 atatctccta aagggacaag gaatagtaag ccggcaacgt atccgatttg ggtgagtgtg 516961 acaatcaatc cagcaccgct tggagaaagt ccaattgcct tactaattaa tccgaccaag 517021 ggttgtgcat agtaaagatt agcaacaatg ataccgcatg cagttgcgag aagaagggtt 517081 aaactgggtg aaatcctctg acctgcttgt ttgtttccat tagccatatg aatgaactcc 517141 tttttaagtg gttttttgag tgtaatcatg acttctcaca agtgatttta taaactgaac 517201 gttcagtttc gtcgattaat aaaaataata tactaaacgt tcagttttgt aaatggattt 517261 ctgttttctt tttttattca atttaagtat actgaacgta tagtttatat tgcgggaagg 517321 aatgatttat gtgcagagta aacgagggcg gccgcgtgat gaaggaacgc ataaggcgat 517381 tctctctgca gcctatgacc tattgctgga aaaaggcttc gatgcggtga cagtcgataa 517441 aattgccgag cgtgcgaaag tgagtaaagc aacgatttat aaatggtggt ctaacaaggc 517501 tgccgttatc atggacagct ttctttcgac cgcgacggac aggctgcctg tgcctgatac 517561 agggtcgtca gtacaagata tagtaaccca cgccacgaat ttagctaggt ttttgacaag 517621 ccgggaagga accgttatta aggaattaat aggtgcaggg cagttggatg aaaaattggc 517681 agaagaatat cgcacgcgat ttttccagcc tcgccgcctc caagcgaaag gccttctaga 517741 aaagggaatt cagaaaggtg aattgagaga gaatcttgat attgaagtaa gcatagatct 517801 catttacgga ccaattttct atcgtctgct tataacaggg gatgaggtga atgattccta 517861 tgtgcgtgat ttggtgatga atgcgtttaa gggagttcaa gctacctctg ctacagagag 517921 tatgtagctg ataagaactg caaaagctgc ggattatatg acaaattggt tccatcgtac 517981 agtgaaatat aagatttttg ttgctgagcg gaatcatcga gggaaaagtt ctcttatcgg 518041 atgtcgaaaa agaagtcatt caatcgtgaa tacataacat catattatta cattcctttt 518101 catcgattgg aacaagggtt ctatacttca atggaatacc gcaaagttgg agtatttaaa 518161 caacagggga aaatcgatgg ccattatgta ggtgtcatgg caatggaaaa aatacttgca 518221 atgtaaacag gcctctaaag agacctgttt tttaatatcc agatgattgt ctagtttcag 518281 cttgggctct atgaccactc ccataactga aatagtctaa tatttatacc agaagggatt 518341 gtttatataa ataaaagttt atataatgac gggggcgcta aggaaacgcg gggagcgact 518401 caggttttcg tttcaaagtt ttgatcctta agatatacgg agcgctacat atggaaacgt 518461 aaaggggaat gtataatcat ttggcgtgta tataacgatt tgcttatata ttgatttggg 518521 aaggaggagc tcatatgacg attgatgttg cggcgatgac tcgttgtttg aaaacactta 518581 gtgatcaaac taggcttatc atgatgagat tatttcttga acaagaatat tgtgtctgtc 518641 aattggttga tatgttcgaa atgagccagc ccgccataag ccagcatttg cggaaattaa 518701 aaaacgcagg ttttgtgaat gaggacagaa gaggccaatg gcgttattat tcaataaatg 518761 gttcctgtcc tgagtttgat acattgcaat tgatcttaca tcaaattgat caagaggatg 518821 aattgttaaa ccatatcaaa caaaagaaaa ctcaagcgtg ttgccagtaa ggaggcatta 518881 gattgacatc aatgattttg gcagtattca tctttttatt aactctagta ttggtcatat 518941 ggcagccgaa aaatttatct atagggtggt cagcctgtgg aggcgcagtt ttagctctaa 519001 tagcaggtgt tgtcaatttt catgatgtgt taactgtgac agggattgtt tggaatgcga 519061 ccttggcttt tgtggccatc atactgatat cgttaattct tgataatatc ggtttctttg 519121 aatgggcagc gcttcatatg gctaaggctg caaaaggata cggtgtgcgg atgttcgttt 519181 atgtatctct attaggagct atcgtcgccg cgttatttgc aaatgacggt gcagctctta 519241 tattgacacc aatcgtatta gcgatggtca gagcattaca ttttaatgaa aaattagttt 519301 ttccttttat cattgccagc ggatttattg cggataccac ttcgcttcct tttgtagtaa 519361 gcaatttggt caacattgtt tcagcggact attttcatat tacgtttatt gattatgcat 519421 ccagaatggt tgtcccgtac ctgttttcgc tgctggcgag catcattgta ctttaccttt 519481 tctttagaaa aagcatacca aaacgctatg atctgactga ggttaaaaaa cctgttgaag 519541 caattaaaga tcaaaacatg ttcagactgt catggtatat cttagggctg ctgttaattg 519601 gatattttgc aagtgaattt ttttctatcc ctgtatcagt ggtagcgggc agcattgcaa 519661 tcattttctt aatcgctgcg caaaagagtc cggccgtcca tacaaagaaa gtggtgaaag 519721 aggcgccatg ggctatcgta ttcttttcaa ttggcatgta cgttgttgtg tatggtgtcc 519781 gaaatgccgg attaacggat gtcctttcag atgtgattca agccgcagct gatcaaggat 519841 tgtttgctgg gacaattgga atgggcttta ttgcggcgat tctttcttcc attatgaata 519901 acttgccgac tgttatgatt gacgcattgg ccattgccgg tacagataca catgggatga 519961 tgagagaagc gcttatttat gcaaatgtga tcggttcaga tttagggcct aaaataacac 520021 cgattggttc cttagcgaca ttattatggc ttcatgttct ttcgcacaaa ggtatgaaga 520081 tttcctgggg cacgtatttt aaaacaggaa ttatcctcac gatacccact ttattgatca 520141 cacttgtcgg cctgtatatt tggctgctga taatccattc ttgtttctaa aaggacaagg 520201 tcactatatc aaggaaaaca atgcactggt aactcttgcc gcagccaaat ggctgaaggg 520261 tgggggagaa aataccttgg ggctaagtgg aatgtgtaca gcgcaggaat cgaagctcaa 520321 ggatgacatc gagtgctgtc aaagcaatga aagaagcagg gattgatatt tcaaatcaaa 520381 catcggagaa atttgatgat ccggcaaaag cacacggaac agaagaagtg tttccaaagg 520441 gtccgtgatg aaattggtga ccgtttaaaa cagtttgctg taactgggga ataaagaatc 520501 gatatattca gcgttttctt gggttatata atacaatgtg ttgttcaaca ggtgtctgcg 520561 agctgagtgc agacacctgt ttttgttttt atttgtctga gattcgtaac agggaagtta 520621 tttagctggt gacagaggaa aattgatttg tgaacagaat catgaaggag acggtgtttt 520681 aaaggagttg tctgttttgc aggaattaac aaaaaaaaaa tacagtagct taaaaacaat 520741 gtttgatgac aaatattgtc ccacatttgt ctattcaata ttagaccaaa ccattccggg 520801 agctgtttat gcagatgatc aaacctttcc taaatcgttt tttataggaa ctgaatcagg 520861 catttatttt attgcgggag accaagggaa tcgggatttt catgatttca ttgcaggata 520921 ttatgaagaa caagtgaaat catcaaaacg atttaccttg ttttcttcca gtgatacatg 520981 ggatagcgta ctgaaaccca tactgaaaga tgacttaaac caaatgagaa gagctgcatt 521041 ttcttatcaa ccaaaatctt tcaaaaagac tttgcaactg ccaaaggggc ttgtattgaa 521101 aagaattgac gaagacatca tttcacatag cacagcgttt aacagcgcgt attatgagga 521161 gtattggaat tctgtctcac agtttgcttc aaaaggtttt ggatttgccg tattacatgg 521221 caatcacgta gtaagtgagt gtacctctat atttttaggg cataatcgag cggaaatgga 521281 tatctataca cttgaagaat atagaggact ggggttagct tattgcgtag caaataggtt 521341 tatagcgttt tgtatggaaa atgggattgt tcctagctgg gattgtgata tttgcaacaa 521401 ttcgtccatt gcattagcag ctaaactagg gtttaagacg gtaacggaat acactattta 521461 ctactctggc taaccttaat gaaagaacct taaaaggaga taccaaccga tgttggtatc 521521 ttttttgttt tagagttttt ttaccctttt agcagaaaaa tgggtgatga aaatcttatt 521581 cattttattt acttttaggt aggtaaaaca taccccgcca actgtaacca ctccgcctag 521641 cagagagagc agtgtgggta tctcgccgat ccagagccaa gatatgatca aggctaaagc 521701 cggtgtaaca taaagtgaaa gggttgcttc tgaagcaccg acgaatgaag tgacatatgc 521761 tagtgcgaag taaggaataa ccgtcggcaa taatcctaag taaacgatag acaaagttgc 521821 gcttattgaa gcgttcatca tctcttcgcc taagcctggc agaaacacaa gcataggtat 521881 tgttccgccc caaatggtga atgtaacgaa tggaataaaa ccatattttt ttatatagcg 521941 ggcttgaaaa acgaaataaa tactctccga aaatgctgcc agcaggatga ccaagatacc 522001 gctcattgaa tatgtaaagt ctcccgcccc aaatgcaatc aataatacac ccaataaact 522061 gatcatagag ccaagccatt tcgtaaatcc aaaatgctct ttataaaaca ggcgggatag 522121 catggctgag aagatcggtg ccgtagtaac gagtaagctt gcaactccgg cactaactgt 522181 tttttcaccg atgttcagca aaatgtgata gaatgcaaat cctaaaaacc ctaaaagaaa 522241 aatggcagga atgtctttca agtcgggtag gcgcatctga gtcaaaacag caaaaagcaa 522301 taatgccata gagccgatta acaaacgaaa taaagcaagg tgttctggcg tgtacccttc 522361 aagtcctgcg cgaattcccg gaaaagcaga tgcccataaa ccaatcatga gactatgaga 522421 tatcattatt tgaactgttt tctttcgcat tcctctcact cctctttaca aaaaccaacc 522481 agttatttaa tgtgtttcta tactaataaa gatttgatga tatggcttca accagttcaa 522541 tagattttga cccaaccaat ttattttaag gagaccgatt ctatgagctt tccagaagaa 522601 aaaaagatga aaaagctccc taagtacaga caaatcgttc attttattaa agagaaaata 522661 ggaaatggag agtggccgat tggaagcaag attccaagcc agcgcacgct tgcaaaagat 522721 tttcaggtaa atcggagcac agtgattaca gcgttagagg aattgatggc cgatgggcta 522781 atagaaggca caatggggaa aggcacagtt gttatcaaca acacatggac actgatggct 522841 aagaattctg ctcccgattg ggatcaatat gtcacctctg gcattcagat gccaagccga 522901 aaaatcgttc aagagataaa tcaatcagaa tcaaatacag accttataca gctcagtaaa 522961 ggtgaacttt cagctgagat ttttcctttg gctgttatga aagagatgat ggggaaggta 523021 tctcaacaca tggaggcatt cggatatgaa gaaccaaaag gttacttacc tttgagggag 523081 gcattaagca actatttaaa aaccattgga atcaacgtct catcttcttc cattctgatt 523141 gtctcaggag cgttgcaagc cttgcagctg atatcaatgg ggctgttaca aagaggatca 523201 accgtttatc ttgatcagcc ctcctacctt tattcattac acgtatttca atcagctggt 523261 atgaagctga ctggacttcc tatggataat gaaggacttt tgcctgaaaa tgttcattta 523321 acaagaggag agcggggaag ggctatctta tatacaaatc catgttttca caatccgact 523381 ggtattctta tgtctaaaaa gcgacgggaa gaaatcctag cagtaagtga gaatacacag 523441 cttcctatta ttgaagatga catttatcgt gagttatgga tcgatgaaat tccgccatat 523501 cctattaaaa caattgataa aaatggacac gtactgtaca taggaagttt atcgaaaaca 523561 ttaagcccag gtttgaggat tggatggatc gtcggaccgg aaccggtgat tgaacgttta 523621 tctgacatta aaatgcaaac agattacgga tccagttcgc tatcccagag agtagcggca 523681 gagtggttta cttccggcca ctaccagcag catgtagaaa aggttaggca gcaattaaag 523741 gtgagaagag aattggcctt gagtgcttta gaaactcatt tgaaagaagt ggcgacatgg 523801 aatatcccaa aaggagggtt ttttgtctgg ataaaaatat tgccttccat atcaatgaaa 523861 ttactttata ctaaagcctt atcaaaaggg attctgatca atctcggcag tatctatgct 523921 caggaaaaag ggaattatat tcgcttatca tatgcttatg catctcttga agaccttcaa 523981 aaggggattt atgagttggg tttaatgatt aaagaattgg caagcaggta acttttatat 524041 ccttaaatgg atgtttcact aaaaaagaga tcaagcctaa tgatcgcttg atctgataat 524101 aacaagggtt actagaatag accaaatcat ggttcggtct taaaataatc atgtctctga 524161 acgaaaagtc tttccgactt ctcttcctaa accaaagtag tgtctgaaat tatagataag 524221 cgggctccat ttggaagggt tgatatggtt ttcgtccaga atgatacttt cctcggcatg 524281 aaaatgtagt gcctgcgtct ctacaattgc gaatgacgat tcatattctg gaagccgaat 524341 gtgtttcact tcggcttcga tttggatagg gcattcttta attcgtgttg gtgatactgt 524401 ttttgattgt aaaggcgtta accctgctgc ctcgtatttt tcttttttat atgtaaatcc 524461 gatctgcttc tttaaaggcg gtatactctt ttttccgcta taagatgaaa ttctttcaac 524521 gttttcccat aaatccgggc caggcaagtt tatgacacac tctttgtgtc tttccaaatt 524581 gtcgatggct tttcctccca gtcctactcc aaggattata taatgtccaa gagcccaaga 524641 agaagacata ggactaatat tagtggttcc atcctcattc aatgtggtta gaagaaatgt 524701 cgaggtacca taatacatga tcttgggttt gatttcctta aatcgacgag tgtcttgttt 524761 tttgatgtcc aacgtttttt cctccttgtc acgcttacat ttatattgta aaggattaac 524821 atttcaacta tcatcgaaat atgaatgtaa ggaggaaaat catgaatcct aatattgcaa 524881 aaatctcttc gttgctatca gatccctcgc gttcttccat tcttctcagt ctgatggatg 524941 gaaggataca ccctgcggga gagcttgcat atctcgctaa cattaaacct caaactgcaa 525001 gttttcacct gaataaattg cttgaagcaa agctgattag cgtagagaag catgggagac 525061 atcggtatta cagattggct gactcagatg ctgcaaatgt gatcgaacaa ttgcttcata 525121 ttgcgcctaa agcaaaagtc aaatctttaa aagagtcaaa agagaaaaag gacttgcatt 525181 tcgcccggac ctgttatgat catttggcag gttatgtggg cgtgcaaatg gcacattcac 525241 tagttgagca ggggatgtta aaaaaagttg atttaaactt tgaggtgact tcagagggtg 525301 ctttattctt ttcgaagtta ggcatcaatg aagagcaaca acggaataag aggagagcct 525361 ttgcccgctg ctgtttggat tggagtgaac ggcagcatca tattgcagga gcattaggaa 525421 acgccctatt ggtgcgcatg ttagaagaag aatggatcgt tcgtatgcct aaaacgagag 525481 cgattaggat tacacaaagc gggaaaatcg cgtttgaaaa gcacctaaac gtgaagattt 525541 aggattttga agcggaaaca tcagatgatg aggcacgata tctaggagga gtaagatttg 525601 ttctaatctt actccttctt cttattttga agcagctcga ttccccattg caatagagat 525661 gcggttccaa ctgtttattt gattaatgat cagaacaagg tcaacatatt gttcctcatc 525721 ataatgttcc cgcacccgat gatatagctc atcaggaacc cttttagatg gaatgagcgt 525781 gatgtgttca gatagttcga gagccgcttt ctcttcaggt gagtaaaaat cacattcatt 525841 ccaagcatgt aaacagtaaa ttcgctgttc agtttctccc attttgcggg catcggacgt 525901 atgcatatct atgcagaagg cacagccgtt catttgagag actctgattt tgattagttc 525961 tctcgtcgtt cggttaattg aggattgttt cgtgtatttc tccatatcca tcatgatttt 526021 cataccttca ggtgcaatct catagtagga cactctttga ctcataaagc aagactcctt 526081 tccatagaat acctagattg tatcccggta ttgatcattt taccaatgtg cggtttgaat 526141 gacagctgtt tcagcgtctt ttggaaagaa gcttctttga ataaaaataa gggtagccag 526201 caatgatgag tggagctgct aatgcaagca gtatccatga gcctgattgg ctgtctctag 526261 tgactctaat gaatatataa gtaccgatca gaaaatataa taaagcacct agaaaccaat 526321 acatgttcat tcctcttttt ccttgctttt tggttgcgca tttttgtctg tcatatggct 526381 taatcgatca gggttctgat tttttaatac cttttcggtc cggattcctt ttctctttaa 526441 tgataaaatt gtgagatcaa tcgatttcaa tgatgatcat tccttcaatg aatagtaagt 526501 tccttatgat tttaaaggta aatttgaaaa gataaaacgt acatagaggc agaacgttca 526561 tgtacgtttg ggcaatgatc acttgttgga aactctaatg tttccctgca cctgatattg 526621 ttgtgttcct tctcttccta taaaatgatt ggatacatgt atgtttgcac gttgaaatat 526681 gggttcgatt ttcatgaatc tctattcggt gaaacaggta aaggaagtgg ataaggtttg 526741 cttataagga atccttttaa agataaatat tactcacatg ataggcgggc attaaacatg 526801 cttgcactca gagtgccggg cctggctttt attctcatga tctatatagc ctctatcgtg 526861 ctgcaatttg tttctggggg ctggtccatt ttattgcttt atgcgtttac catattaatc 526921 gccatttttg ctttgcttca ttggcactca tatcgctggg ttaagaaaag agtgattctg 526981 tatttcgcgg tacaaggttt gatcaccttt gcacttgcta atctcatgac tggcttcttt 527041 atacttgtga ttatcggcct ttatgcattt ttaattggac aaattatagg aatggcagac 527101 agaagaagga cttttctcat tctttatcta ttgctgctgc tggtcataaa ttcggcgtat 527161 caccttcata aaggtgaagt tttgcatttt attgttattg ctgcgccgat catgattgtc 527221 atcatcactt atgccgcaac attttttgcc caagtcgatg aaaaaataaa agctcaattg 527281 actcttgaaa ggctggagct ggctcatcag caggtagaac agctgacgct gcagaacgaa 527341 agacagcgga tggcccgaga cttacacgat acgcttgctc aaggtcttgt cagtttaaat 527401 atgcagctgg atgcgattca tgttcatctc gccaaaggca acacagagag agcgaaggaa 527461 atcatacaac aatcgatgaa aagagtgaaa agcacaatag ctgatgcacg ttcagctatt 527521 gacgatctcc gcagcaaatc agaagaaatc ggtgttttaa aagaaagaat tacctcgcta 527581 atggatcatt ttatagagtc gacaggcatg gcttgtttat tagattacag attgcatcag 527641 gtgctggatg tgcgtacagc tgaaaactgt tattacatca ttggagaatg catgacgaat 527701 gcggcaaagc atgctgaggc gaaaacaatc tggatatcca tttgggatga tgaaaaggga 527761 aggctccatt taacagttaa ggataacggc aagggatttg atgttgaaaa aggaaagaaa 527821 aagagaggac attatgggct tcttggcata caagaacgcg tcagggcaat aaatggccaa 527881 ttcaatatca agagtacaaa attgaaagga acacaaattg agatcactgt accaattcag 527941 ggagagatgc aagatgaata aggttttaat cgttgatgac catcttgtcg tgagggaagg 528001 tctgaagctt ttaattgaaa cgaatgatca atacaccatt ataggagagg cggaaaatgg 528061 aaaagtagca gtccgtcttg cagatgaatt agaaccggat atcattctga tggatttgta 528121 tatgccggag atgagcgggt tagaggccat taaacaaata aaagaaaaac acgatacccc 528181 catcattatt ttgactacat ataatgaaga tcacttaatg atcgaaggga ttgaattagg 528241 agcgaaagga tatctgttaa aagatacgag ttcagaaacc ctttttcaca caatggatgc 528301 agccatcaga ggaaatgtgc tattgcagcc tgatatcctt aaacgtctgc aagaaatcca 528361 atttgagcgg atgaaaaagc agcgcaatga gacgcagctg acagaaaagg aagtcattgt 528421 tctaaaagca attgctaaag gtcttaaaag caaagcgatt gcctttgatt tgggcgtctc 528481 tgagcgaaca gtaaagtcca gattaacgtc catttacaat aaattaggcg cgaattcaag 528541 aactgaggca gtaacgattg ccatgcaaaa aggtattctg acaatagaca actaaactgc 528601 atatttgaaa attgcccaaa cgtacatgcc cgaatgtacg tttttttcat ttcattgtca 528661 actacaatga gaaagaatgt gatcaagcaa tgtgttgaaa ggagattatc atgtcaaaaa 528721 tgttatatac attaggagga tgggttgctc gcaatcgcat aaaagcaata tgtgcgtgga 528781 tcgttgtgtt agttgctgcg ataggccttg cagtgacctt gaaaccaagt ttttctgagg 528841 atatgtccat acctgacaca ccttcggaaa aagcgatgga tgtgattcaa aaagaatttc 528901 ctcatggtcc tgataaaggg agcatacggg ttattttcgg tgctggtgat ggggagaaac 528961 ttactgggaa gccagcaaaa aaagcaatag aagatacgtt caaagaaatc agtaaagatg 529021 attctgttga ctcgattgca agtccttttg tgacagggac aatcgcgaaa gatggcacag 529081 ttgcctatgc tgatatccag tataaatcat cagcagatga tataaaggat tactctatca 529141 aacacttaaa agacagtttg aaaatggctg atgatgaagg attgcaaact gagctaagcg 529201 gagatgtacc gggagcggag atggagatag gcggtgtctc tgaaattgtc ggcattatct 529261 tggcttttgt cgttttagcc attacattcg gttctttatt aatagcaggt ttgccgattt 529321 taactgcact gattggttta ggtgtaagta ttggactggt tttgattggg acacaagtat 529381 ttgatattgc ttctgtcagt ctttcattag ccggaatgat tggccttgct gttggtattg 529441 attatgcttt atttattttt acgaaacacc gccagttttt aggcgaaggc atacaaaaga 529501 atgaatcaat tgcgagagcc gtgggaacag cgggaagtgc agtggttttt gccggactta 529561 ctgttatcgt tgcactttgc ggattaactg tcgttaacat tccttttatg tctgcgatgg 529621 ggctgacagc agggcttagt gtactgatgg ctgttttggc ttccatcaca cttgtgcctg 529681 cggtcttatc gattgcaggg aagcggatga ttccgaaatc aaacaagaaa atagaaaaac 529741 aaagcactga aacaaatgtc tggggacgct ttgtcaccaa aaatcctatc atgctaagtg 529801 tatgcagcat tctgattttg atcgtcatta gtatcccatc tatgcatttg gaactgggct 529861 tgcctgatgc tgggatgaaa gctaaggata atccggatcg ccgggcatat gacttgcttg 529921 ccgaaggctt tggagaagga tttaatggcc aattaacaat cgtagcggat gccacaaatg 529981 ctacagaaaa taaggcggag gctttcgcag atgcagtgaa agaaataaag ggcttagacc 530041 atgtagcaag tgtcactcct gcaatgccta ataaagaagg gaactttgcc atcattacgg 530101 tcgttcctga aacaggtcca aatgatgtca caacgaaaga tttggtacat gatgtacgca 530161 gtttatcaga taaaaacgga gtagatttgc ttgttactgg atcaactgca gtgaatattg 530221 acatttcaga tcgcctgaat gatgcgatac cggtgtttgc tgtacttatt gttggctttg 530281 cgtttgtatt gctgaccatc gttttccgtt cgctgcttgt gccgcttgtt gctgttgcag 530341 gtttcatgtt gacgatgaca gccactcttg gaatctgtgt atttgtcttg caagacggga 530401 atctcatcga ctttttcaaa atacctgaaa aagggccgat actcgcgttc ctgccgattt 530461 tatcgattgg gattctgttc gggttagcca tggattatca agtattcctt gtcagcagaa 530521 tgcgtgaaga atatgtaaaa acaaacaatc cagtacaagc cattcaggct ggattaaaac 530581 acagtggtcc tgttgttaca gcagccggct tgatcatgat cttcgttttt gcaggattta 530641 tctttgcagg cgaagcttct attaaagcca atgggctggc tctttccttt ggtgtactct 530701 ttgatgcctt tattgtaaga atgacactga ttccaagtgt catgaagctg atggggaatg 530761 cagcctggta tttgccgaaa tggttagaca agattattcc gaatgtggat atagaagggc 530821 atcaactgac aaaggaaata cagccggaaa tagatcatga acaaaagaaa caaatcagtg 530881 tgtaatagaa aaagcagatc ttttatgatc tgctcttttg cttatggtag tatttagaag 530941 atgaagtcgg cagttaaaag gagacgctta tggcgccatc actcattttc gatatggatg 531001 gaactttgtt tcatattggc agaagctgca tcatactagc aggcatccca ggagaagtga 531061 catgattttt tgactttgca ttcactactt gatgccaagg atcttgagaa tccttcttga 531121 aaataaagga ttttacaact gatcatataa gaaacctaaa gaaacaagca cacaaaacca 531181 gctgcgggtt ttgtccaaga aaaatagagt ccataagagg gactctattt tttgaagtgc 531241 ccggctagaa gcatattgca ggactttatg aatgcaaatc actatcttat aagcccttac 531301 cgtgaaatgc ctgtttctgc attgaaaaaa cgcattacac gttcatttac gtaagtgggt 531361 tgttccatcg ataaaacatg tccggcattt ttaatgactt ccgcctcaat atctggaacg 531421 aatgaagagg ctcggtgcag ggctgagtgg ggatcataga tgacttcatg ttcaccaagt 531481 aataatagga taggaactct tgctgaacgt aattcctcat cggtaaaaac atacggaaat 531541 ccgtcggcat taggatttgg atttcttgat ccatcctgcc acattacccc tgccttaaac 531601 tgcttcacaa aaatcgggtg cagcacattc tgatcattca tcatccaatt taagaatgtt 531661 tcaactccat ttgacgctgt aaggccaaga gcgtatttgt agaaatcgtg atgaaatggc 531721 aaaaacgttt ctgccggact cagtatagct gcgcttttta ctctctcagg catacgtaaa 531781 aggaaattca tcgtatggag accgccaagc gaaagtccga tcatgtggga cttttcgatc 531841 cccagattgt caaacacatc aagaagccaa ttggcgtaat ccgttcttgt accgcttaca 531901 ttctcaggaa tactcttgtt tttatcacct atgatatcaa ctgcataagt tctgtattta 531961 ctgctccaat cggcgatgtt gggataccac atcgtcgagc tgaataatgc tccgtggagt 532021 aatacaagcg gcggggcatc ctctgggccg cttgcaatca catgtgtttg accaaaacga 532081 gtagatatat agaatgattt acaacggacc ggccaaagac taaggctttc attataagtt 532141 tgataatagc ggataccgtt gtcacttaat tcgggaatac tagatgaatg gtttgacata 532201 caaatgcccc tcccaatttt gtttaaatga atgtgccgtt tcgtgatggg gaatctgatt 532261 ttgatataac agactttatt tacaatataa tacagttgtt attagacgtc aaatccaaga 532321 tgaaaaggaa aaaaacgatt gaaacagatt attgaaaatc aatataacag aatattaacc 532381 tcctttgtgg agccgcttca ttaaaaccgc aatccaaatg catgaatcac aaaaatcaca 532441 acaggaggga tcaggaggga aggcagcaga ttcagtgttt tgaacttctt gattccaaga 532501 atgcttagac ctgaactgag gatgagtatg cctcccacaa ttgtgatttc attaataagg 532561 tctgtattga ttgcgctctc cattacttgt gcaaataaat agatggagcc ctgccaggaa 532621 aataatacaa gtgcggcagc cgctattcca aaaccaaaag ttgaagcgag cacaatggag 532681 gtgatcccat ctaacatccc gtttgtcaga aggtatgtat aatctccatg caaagcggct 532741 tcaacagggc ctaatattga cagcgaacct atacaaaata ataagaccgc agttgataag 532801 ccctctgcta aattgctttt agaaaatttg ttcaccagct tgttgaatcg taattctaaa 532861 ttgatgatct ggcctagcaa acctccaatg gctaaactca cgatgaatag aatggggtat 532921 ttactatcag gcaaatgctg tgtaatggcg ttgatcccca gtgcgaccgc agcgaatccc 532981 attgcctgca tcaaaatatc ctggtattca tctttaatgc cttttttgaa tatccccccg 533041 attatgcttc ctgcaatgat catcactgtg ttaaaaatcg ttccaaacat aagctttctc 533101 ctccaaaaat cattcctgca taaaaaataa accctctagt tagtagagag tcaagggaga 533161 tcaaaacata ttcatgagat tatttgatgg gcagcaggat ttcagtcacg taattatcta 533221 ggttattcgt aatgccataa tcaatgagtg tgatttcgat tgagtcccct gctacctcat 533281 aatgatgttc tttcatatat gccagtaatt ttttgtagta tggttcggct tctggatgtg 533341 accctttaaa cctaatttgc agatattctc ttgaaggaaa gatgatttct gaagaagttt 533401 tttcattttc atcttcaaga atcataaata tactggaata tttgtcaaac tgttttgctt 533461 tcacatttgc tgcagaaatg gataaaccaa tcttgcctat gaatatatct tcgtttacat 533521 tcaggtgggt tctcaattca gctaacgaat gttcgatatc atggccgaga acatattcat 533581 gctgcaaata ggccacacgc attgcgggaa gtttgatttt tgaaatttga tgtaacggca 533641 tgttaacggc atcttctata tgtgtgatgc gtcgggagat ctttcgttca atgcgttcca 533701 attctttctt cttgcgatca atttcaacct gctggctttt tagtaaatga agaagagtgt 533761 ttgtattttg agagttataa aaatcaagaa gcttattgat tggcaggcct agggccctca 533821 aatacttgat ggtatccagc cgctcaaact gttgggtaga ataatatcta tagttcgttt 533881 gctcatcttt atattccggt ttcaaaaggc cgatttcatc ataataccga agagcagaga 533941 ttttcacatt gaataacttt gacacttctc caatcgaaaa aaattccttc attctaacaa 534001 cctttctgtc ctatgattga tatacacaca ttatatagta cggcgagtac taaaggtaaa 534061 gtttgcagca taaagaaaaa actccttcta aaaaggagct tttcattctt cgaaataagg 534121 atttacatgg atgagcactt cttctacatc tgaaaactgt cttttgattt catttcgaat 534181 ttcgcgggca atgtcgtgtc cctgcttaat tgtcaaatca tgatccaaag ataaacggac 534241 atcaagcaat ttatagtggc catgttctcg cgcgcggatt ctatcaattc gttttacctg 534301 atcacattga aaaataacag ctttatattc ctctatcagc tcgggatcaa cactcttttc 534361 catgagcaca tcaacagacg gcctgattaa ttccattgaa atcttaaaaa tgaggtaagc 534421 aacgattgca ctggcaatgg catcggcgta caacagatag gaccatccac ggctgtttcc 534481 gatgatagcc aacaggacgc cgataaaagc ggcaagagag gcaacgatat cgcctttatg 534541 atcgtacgca atcgctataa tcgctttgct gttccatttt ttcccttgct ttatagaata 534601 acgatataag atttccttag ccacgtacga aatcagagcc gcaaacaatg cgctgtattg 534661 gggaacgctt ggccctttaa caaaggacag aatcgcttct atgaggatat aaacggatac 534721 gatcactaag ataattccta caatcgcctc actaatgact tcagcttttc cgtgaccaaa 534781 aggatggtct tgatcgggcg gtttattgga aattccgatc actgccaaga ctgcaatcga 534841 agcaacgaca tctgccgcgg aatgtattcc gtctgcaaac acggcttcac tatcgcctac 534901 cagcccaaaa aagacctttc ctgccattaa gatcagattg gcgatcaatg caatcaaagc 534961 aacttttctg cttatttgtt ctctttcact tgccattttt tcctcctata aaactgcaca 535021 aaaaaatagg agtgctctat atacgctctc cgtatccttt cctgtgtaat cactttgttt 535081 atcataccaa ttcaatttcg agtgggtcta tagcaacgtt gtttcctgtt tactaataaa 535141 taaggtgaca gaaaaaaagt tggagctatg ctaaaaaggt catacagcaa acaaatgagt 535201 tcttatgtaa caacagtgat gattcgctat taaaatgctg ccgtcagtga aaaatttcca 535261 cctaattttc aaaaacctat tgacatgaga agatctgtat tttactatta tctcatattc 535321 aagatatttt aatttgagat atttggtcgg aaagatcagc gatcaagcgc aactctaagt 535381 gttcaatcgt tgtcagttct tttacacaat attcaatatg attttttata acataatatc 535441 tcgaattcga gataaaaggg agtgtagcgt aatggctgaa tttactcatt tagtcaatga 535501 aagacgatct gcaagcaatt ttctttcagg tcatccaatc acaaaagaag atctcaatga 535561 gatgtttgaa ttggttgcat tggcaccatc ggcttttaat ttgcagcata caaaatatgt 535621 gacggttctt gaccaggacg taaaggaaaa gctgaagcag gccgcaaacg gacaatataa 535681 agtggttagc tcttctgcgg ttctcttggt attaggggat aagcaggcat atcaacaagc 535741 ggccgatatc tatgaaggtt taaaggtatt ggggatatta aataagcaag agtatgacca 535801 catggtgcaa gacaccgttt cgttttatga aaacagggga gaacaattta agagagatga 535861 ggcgataagg aatgcttcac tttctgcgat gatgtttatg ctgagtgcta aggaaaaagg 535921 ctgggatacc tgcccgatga tcggctttga tgcggaagcc gtaaaacgga ttttgaacat 535981 agacgaccaa tttgaggttg tcatgatgat tacgattgga aaagaaaaaa cagagagcag 536041 aagaccgcgc ggctaccgga agcctgtgaa tgagtttgtt gagtatatgt aaaaggagcg 536101 gataaaaatg gctaaaaaaa cgatgggaat tcatcatatt acagcgattg tcggtcaccc 536161 tcaagagaac acagattttt acgcaggagt gcttgggctt cgtttggtca agcaaactgt 536221 caattttgat gacccaggta cgtatcatct ttattttggg aatgaaggcg ggaagccggg 536281 aacaatcatt accttctttc cgtgggccgg agcccgccaa ggcgtcattg gagacggtca 536341 agttggcgtg acttcgtatg tcgtgccgaa aggggctatg gcattttggg aaaagagact 536401 agaaaagttc aacgttccct acaccaaaat cgagcgcttt ggggaacaat atgtagaatt 536461 tgatgatcct catggactgc acttagaaat cgtggaaaga gaagaaggag aggctaatac 536521 gtggactttc ggagaagtaa cgcccgatgt tgccattaaa ggttttgggg gtgcaaccct 536581 attatcagag cagcctgaca aaaccgctga ccttttagaa aacatcatgg ggctggagcg 536641 agtcggcaaa gaaggagact tcgttcgtta tcgttccgcc ggtgatatcg gaaatgtgat 536701 tgaccttaag ttaacgccta ttggccgcgg gcaaatgggg gccggaacgg tgcatcacat 536761 cgcttggcgg gctaacgatg atgaagatca gttagattgg caaagatata ttgcttccca 536821 cggatatggt gtaactcctg ttcgggatag aaactacttt aatgccattt acttcaggga 536881 acacggggaa atcctgtttg aaatcgcaac tgatccccca ggctttgcac atgatgaaac 536941 acaggaaaca atgggcgaaa aactgatgct gcctgtgcaa tatgaaccgc atcgcacaca 537001 aattgaacaa gggctgctgc cgtttgaagt aagagagtta gattgatttg acacataaaa 537061 aataaagaaa catatattca attgatgatt gctggatggt actgtcagca aagaatcaga 537121 taaaatcaaa gatgaggaga gatacaaatg gaagatgcag gactgttgct tattcgtata 537181 atgattggtg tggtgttttt gttttatggc acacaaaaat tattcggctg gtttggcgga 537241 tacgggatta aaggaaccgg acaatggttc gaatcaattg gggtgaaacc aggaaacgtt 537301 gcggccgctc tatcaggtct tggggagtta gtaagcggaa ttctatttat tttaggcgta 537361 ttcctcccgc ttggagctgc tatcataaca atcatcatgt taggtgctat cgtaaaagtc 537421 catggagcga aaggttttgc gaatggcgcc ggaggttttg aatataacct ggtgctcatt 537481 gcagtttcca taggggttgc actcatcggt tcaggagctt acgctttgca tttttaatac 537541 gaaagtatgt aagaacagtt gctgcttgtc agtaactgtt cttttatttt cacattttcg 537601 gcaagcttgc aggtactctg caaagcaaaa aagcggatat cataaatata aatctgtata 537661 gtgaatgata cgtattgatg agcttggtca tgaaaaacag acctatttga aggagtaaat 537721 ggatgaaaga gatgacagga ttacattcat tagtttctat agaaaacttt atcaaacagc 537781 acaaattcag ttttatttat atatcaaggc ctggctgtac agtatgtcac gcagttctgc 537841 cccagctcag aatagtattg gatcagtttc caaacatcaa attggggcat atcaatgctg 537901 acgatgtagc agaggtcgcc ggcagatttt cagttttcac cgttcctgtg cttcttttgt 537961 tcattgatgg gactgagttt ctaagagaag cccgttttgt tcattttgaa cagcttgaac 538021 aaaagctgaa aagggtttat cgattatatg aaggcgaata aaggaataag gcaaaaaaag 538081 aactcaaatg agttcttttt ttattcttca ctaggcgaag aagggttatc aacctgccct 538141 tgatcacttg tatcattatc acaacttgct gaaataataa ttgaatgaga aggagagtaa 538201 tctcctaatg tgaaattcac tccgtaattt ttgctgttcg cagtatggct gttttgcaag 538261 ttttgtccga tatctgtatt ggcgttttgt gtcattccat ttatcgtgag atttgagatg 538321 ttgatttgag atcgcatgct tcaaaaactc ctttcactca gaagtagctg tcataaagga 538381 cgctggcagt ctatttactt ctatgatatt gcgtttttat atcattgcat caacataatg 538441 gtaaaaataa tagcgagtga atgatcatct tttgaagatg atcaacctat cagcagaaat 538501 aaagccgcct gataaagagg cggcagatcg ttatatgtca tctatgaatt tgatgtatcg 538561 tttttcgttt gcctgaagga taagatagtc gtttttaatg atgagtagga gcctatagca 538621 gcgtagccat aaaaccagcc cataaatacg ccagaaaaga ggctgtgtcg atggcttatg 538681 aaaacagaaa tgacaaggcc tgttattaag gcaactgacg gtacaaaagt tttggggatt 538741 ttcaataata ttttgaggat ttgggttatc aatatgatga ttggaacagc tatcacagca 538801 tcccaaaagt tcgtgtgaat aattggaaaa gccatacggc acctcatgaa gtgtttattt 538861 cttaattttt acgctaaaag cttggaaagc agctcttgga tcgcatatgt tacattttgg 538921 gcttgattgg cggagcttgt ttggcttaaa gcattggatt caaaaaccaa acctgtatta 538981 ctcccaccgg aaccctctgt tgttttagac acagagaacg ggctgatgga aactgcaaat 539041 ccgttattaa aaacgctgtt cccggatatc gaatgaatat aaactgggaa tttcatcatt 539101 catctctcct ctctgttatg actgtttata caatatggtg tgtgagcagc agttgcttaa 539161 acaaaacggc aaaaactttc agtaagagac aaaaacctgc aaaatgccac aagcgccttt 539221 tgttaatgca gctttttagg gacgtttttt ttattttttt tgccaacttc atcaaaaata 539281 ttctgattgc cagactgggc ttgtccgtcc ttatttatga aatcggggtg aatgagtttt 539341 ttcagatccc tgactgttaa aggcttggcg tcatcagtta attctattcc taattgcccg 539401 tttgcctcta atgtcgcaat tttgacatct tgtatagccg taacgccgtg aagccttagc 539461 tgcatttcaa gctggtcagc tgtaagtctc atcttcttta agttttcgat atgaagctgt 539521 ccgttttcaa tgacgatttt tgcttttccg gttaacatct tttcaatggt gttcgatttc 539581 atttggatcc attccataac gatgagtgtg cttgtgaaaa ttgccgctgc aattaatgtt 539641 ttgaagaggc tgtactcgat gattggctga acgataatag ttccgatcga aatcatgaca 539701 accgtttgag tcgacgtcat ttgtgcgatt gatttccttc ctgaaattct cagcaaaatg 539761 accccggcta caatgagaac aagagattcc caagtgaaat tcatgctacc acctgaccaa 539821 tgatgaatta gatttgtcat gggattggct tttcttccgg ccaatcgcaa tttaatatat 539881 ccgaaaggca gtcggttcat tctgtcctga accgaacaat atttttggta tagatggata 539941 tattaagcca aacaatgata gcaacaggag ttttttggcc gaaacaatct gggaagcggg 540001 gagcgccata acatgattga acttgaagtt gtcattagaa cggttgccag ctttggcttg 540061 ctgttaatcg cagaacgaat tttaggcaaa cagacaatct ctcaaatgac gatttttgat 540121 tttattgcgg cgatcacact aggggcgatt gctgccggat tagcttacaa tacttcaata 540181 aaaccgcaca atatggccat ttcgtttagt atttttgtgc taaccatttt tctaatttcg 540241 tttctgtcga taaagaacag gaagctgagg aaattttttg ccggagatcc aacagtgctg 540301 attcaaaacg ggaagatact tgaatcaaat atgaggaaaa tgcgttacac acttgattat 540361 ttaaatcagc aattacggga aaaagaaata tttaatatcg aagaagttct ttttgccatt 540421 cttgaaacga atggtcagct gactgtgtta agaaaaccgc aattccggca tgtgaccaaa 540481 caggatttaa tgattgcggt aaaccaagaa caaaggcttc cgatagaact tattatggac 540541 ggagaaatca ttgagaataa tttaaagcag aatcgtttga cggaatcctg gcttttggaa 540601 gaattgcgaa aaagagacat aaaggtgaaa gagaccgtgt acgcagtgct gctgggtaat 540661 ggggatattt atgtggatca atataaagac catatatcag tccctatgga taaggaatga 540721 aggaacaatc aatcttaaag ccccttattg aacgcaacgg tttcaacttg tcttgggtac 540781 gaaatatgca gaagcccgtt taacagctga atctgtaaca aatgagtttc agcggcttcg 540841 ggaagctgaa tgattcgctc aatttctccg taataccgtt cacgcagcac ttccatttcg 540901 gctggaaaaa caggcgtgat cgttcctttg atcagcagct gggttttaga cagtaaacgg 540961 atcgttaatt cttcctcata cacaccgggc atttccacaa tgataaaatt atattcctca 541021 tcttgataaa agtcgtaaac aaacgtagaa gcttcggaat caaaaaaatg ttccggggct 541081 ttatatttga gcacatttgt ccaaaagtca ctttgtttat attcattcgt aatctcaagc 541141 cactttcgaa ttttttcgaa atccatatga gattctcctt aaatttgatt tgaaatcggc 541201 gcagaagggt ttccgatttg gtcttggtca ctaacgtctg aatcaatatt tccagtgttt 541261 aaaagtgaag acgtaggcga aagatcccct aaggaaaagt ttgctccaaa atatttgctg 541321 ttcgcagtat ggctgttgtg cacagtcgga ccgacatcta tatttccgtt ttgcgtgacg 541381 ccgttgatct taatatttgc gatattaatt tgatatggca tagacgaaac ccctttaatc 541441 taaaattggc ggtggtgcaa tcggaggagc attaacgttg gatgtatcag agttgccgat 541501 agatgtctgg tcatttacat caggatcgtt taagaagttt tccattacgg attctgtagg 541561 tgatgtatca ccgaaagaag agttggtccc ttgagatttt tgattgttgg tagggctgtt 541621 ataagcagct tcgcctattg taattgaacc attgcccgaa atactgttga tcttcaaata 541681 atataggttg attactgtag acggcatccc atcacaccct tccatctttc tgtacagtac 541741 attatgcgcc gctgcaccca attgttcctt gcatttacgg gcaaaactct atctggcccc 541801 ggagtgatgc tcaattatca gtgaatgaaa agccattgat ataggaatca atgaattgat 541861 tcagttattc gaaatgcatg agacctttta ataaaggaag ctggcaaaca ggatcagttt 541921 gaaataattg acaatgaagc taatgccatg aaataatact cgtgagtaac attactcgtg 541981 ggtattattt ttggggtggt cctagttgaa aagtaaagga gtagaaagcc gaaaacgatt 542041 acttaaagct gccgctaatg aattttcggt tcggggattc catgacgcga aggtaagtga 542101 aattgtgaaa aaagctgggt tcacgcagcc ttcattttac ctgtactttc aaagcaaaga 542161 agccatcttt gccgagttaa taaccgattt tcactctcga gtcagaaagc tgacagagtc 542221 acttcttctg gaaaacggat taaacacgga ggatgtgtca aaacgggtac tgctagctgt 542281 agagactgtt tttcaatttt tggatgagga caaggattta accaagatcg gcttttttct 542341 caacccggaa gcaaaacaaa tgaaaaaaga cttggcgatg gttttgaaag agaacttaga 542401 agcagaacag cggcttggct attttcactc tgaactggat atggaaactg tcgctgagtg 542461 tttggtcggc atgattgaac atttaaccga atcatttttg ttaaccggaa tcaaagatcc 542521 ggcaagcctc gcagcagagg ttgtgaatct tttaatttac gggatgcttc cgaaagggaa 542581 tgatgtaaga tgatatctat tatgatgaaa gtcagtttgg cagtttttat gcttgcggga 542641 ggcatcataa aggtaagccg cgttcccttt caagttgagc attggcggca ttatcaatat 542701 ccattatggt ttctgactgt tactggcatt cttgaaatag ccggggcact tgctatgaca 542761 gcgggaattt ggaatcggta tgcagcaatt ggagcaggtg ttctgtttgt cgttctcatg 542821 gcgggagcaa ttcatgcgca tatgtttcga gcaagacaat ctgtcatcat ggcgatacaa 542881 gcgatgattt gtttgattgt ttcaatcatg atcatcatgg ggagttacac gtaagctttt 542941 cactaatgtt taagaacaag cccatttgca ggaaatctcc ttttcttatc gaataataga 543001 aagtccagga attaactgaa tcagtaaaat agagctccat ttctgtgtta ttcgtccggc 543061 atcagctggg ctttttttat aaaggaggaa tacaggatgg cattcacttt ggaagacatg 543121 actgaggaag agttcgaagc ctttcgcggg atgtccgtgc aaaattttgc gaaacaaaac 543181 ataacgtcag gaacttggac ggaaaaagag gcatttgaga aatcggagca ggcatatgag 543241 aacatgattc cgaatgggcg agacagcagc aatcattatt tttggaacat cacaaatgac 543301 caaggagaaa gaatgggctg gctctggctg tatgctgatc cattacatcc gcaaaaggaa 543361 gcgtttatct attcctttgg attgtatgaa gcctttcgcg gaaaaggact tgctcaattg 543421 gcgcttcaaa cgcttgatga aagagcaaga gagcttggtg cggaaaggct ggctctacat 543481 gtatttgcac acaacgagac agccgtctat ctttatcaga agatgggcta tgccatgacc 543541 aatatacgta tgcggaaaca gctatgctga aaagccgctt acgttaccca aatacaacat 543601 gcctatctgg aagcggtggc agggtactat aagtcatcat tagaaagatt aaggtcatgg 543661 gaggcttgaa catataaaga aaaaggacaa cagctgttgt ccttttcaat gccgcttgaa 543721 ctttctccct cagtcttttt tgtcttgatg atccagctct tttattcgtt tcgtaagctc 543781 attgaaagcc tgatcaagct ccttataccc tttatcattt ggcgtcataa aactgagctt 543841 tcccagcact tcttgtcttt ctgtctcaag ctttaaccga agctcctccc gctcatttct 543901 ttctgaagga acgtcgttta actgcttttc gatgccgttg tttgagatga cgagtttact 543961 gtttgttgtt ttttcgagaa agtatcggtc atgtgaaacc gccagcaatg tgccgctgta 544021 ttgtgacagt gtttcttcca gctgttcgcg tgacggcagg tcgagatggt ttgtcggctc 544081 atctaaaatc agcacgtctt tttcctccag aatatatgcc atcagcttga tctttacacg 544141 ctcacccata ctcatatgct tgatcggttc agtccattgg gcggctgtaa aacctaagtg 544201 cctcatcaga ttttgaacgt gcccccttgc tttgaatgtt tcattctcaa ataactcttc 544261 cggtgtttgt tctaaaggca aatcaaacac ctcctgcgtt aaatagccga tgtttgcgga 544321 cggcgacacc catacacttc cttctgctgt ttcctgtccc agaatgatgt tcagtaatgt 544381 cgtttttccg ctgccattgg ggcctatgat cgcaaccttt tcgccgtgct gaattgtaaa 544441 gtttgcgttt ttaaagagag tcctttctcc aaacgctttt gttacattct gaacttctaa 544501 aaaacgtttt cctgttttgt gggttgtatc gattgaaaag cggactgtat attctggggt 544561 aacgggttcc gcctttgctt tttcaagctc tttttcaagc cgcttctgct tggattttat 544621 ctgggcatcc gtacgcttcg cttttacccg gtgatattct ttaaaccctt cctttttcgt 544681 cgattgagca tgggcttttt ccgaccaaga agcgagccca ttcatttgtg cttcaatccg 544741 ttcaaccatt ttttgctgct tttcatattc acgctgctgg gtgagtcttt tcttctcccg 544801 gaacttcata tacccggagt aattcccttt gaattcaatc agcgtctgat cctcaagcga 544861 ccatattttt gttgcggctt cgtctaaaaa atatcgatcg tgagaaacga gaatcacagt 544921 gccgttataa tgtttcagct gttggatgag aaattgcaag cttttttcat caaggtggtt 544981 tgtcggttca tctaacagca gcagatctgc atcctctgat agtcctttcg ccagccgcgc 545041 tttcagtttt tcaccgccgc ttaactgatg aaaatcacga agaggcacat gccatttctc 545101 cagtaacttc ttttcggcag gtgtctgatc cgcaaaggaa tacgccgcgg tttcctgttc 545161 aaccaaagcc agttttatat ccttccgaag gatttgaccc tgtgcagggg ctaagtcatt 545221 gtgaatgagg tgcagcaacg tagatttccc agcgccgttt ttgccgataa tcccaatgat 545281 atctccttgc tgaacactgg cgtttacatg tttaaaaaca gtttgatcct ttacttcata 545341 gctaacgttt gttaatgtta cgatctcttt catccatatc cctcgcttta aagggagaat 545401 aaaaaaatcc tcccaaatgt gttggaagga ttagccgtgc ctgtgcatga tcaaataagc 545461 tattttttat aaatagcagt gtcgtatata tagaaaatgg gcagactaat cctatttttt 545521 gatttgaaat attgatttca aacggtaaaa ataagattag ttaatcattg tccacccatc 545581 atcccttctt gttttgatta caaacactat agcatacctt taaattcaaa agcaaaggtc 545641 attttcatca aaaaaactcc tgctctcatt tttgaggcag gagttttgag tcttattgat 545701 gcttcgcttt tctcacttta taaatcacaa tcagcaaaat aaaccaaacc ggtgtgacaa 545761 ataaggaaac acgagtatcc tgtgccagtg ccagcacaac cagaacaaac gccaggaacg 545821 caagaatcag gtaatttgta aacggataaa gcggaagctt aaacttgttt gttttcgcta 545881 attcaggtct tgttttgcgg tatttcatat ggcagatgac cgtaatcccc caaatgtaga 545941 taaagcatac ggttgaaata cttgtgatca gggtgaatac gccttctggc atgatgtagt 546001 ttaacgtaac accgattaaa atcacgatag ctgaaaagaa taaagcattt ctaggcactt 546061 tacgctgagt cagtttcgcc attgactcag gcgcattgtg atctttcgcc agggaataga 546121 ccatacggct tgtactgaat acagcgctgt tgcatgctga agcagcggat gtcaacacaa 546181 caaagttgat aatacttgca gccccgacga tgccaacagc gacaaatact tgtacgaatg 546241 ggctttcgct gggattgatg atatcccaag gatagatgct cataatcacg agaagagccc 546301 cgatataaaa aagcagcaca cggacaggaa tattgttgat cgccttaggg attacttttt 546361 cagggttttc tgtttcaccg gccgtaagcc cgacaagctc aatgccgaca aaagcaaaca 546421 caaccatctg gaacgagagg ataaacccgt gcatgccatt cgggaacagg cctccgtggc 546481 tccagaggtt tgtgaagctg gacactcctg agcttgtgga aaagcctttg aaaatcatca 546541 caaggccaat gacgattaac gccaaaatgg caatgacttt aatcaaagcg aaccaaaatt 546601 ctaattctcc aaaaagcttg actgtcgcca gattcataat cagtaaaata ataagagcga 546661 ttaagccagg cacccattgc ggcacacccg ggagccaata ttgagtgtag agcccgactg 546721 ctgtcagatc agccatcgca atggaaatcc agcagaacca atatgtccag ccggtgataa 546781 aagctgccat atcgcctagg tagtcttgta caaaatccac aaaagagtga tagttcaagt 546841 ttgataacag cagttcaccc agcgatctca taattaaaaa gcaaatgatc cctgtgatca 546901 tataagcaaa taaaatcgaa ggtccggcaa aatgaatcga tttgcccgag ccgagaaata 546961 agcctgtccc aatggctccg ccgatggcga tgagctggat atgcctgttt ttcaagcctc 547021 tctgcaacgt ttgctgattt atattgtctt tcgtcatgtc gtctgtcact ttatgtgttc 547081 ctccattgaa aattgtttat tgagtcagca atctattttt aatgattatt ataacactaa 547141 aatttctatc ttttttacta aaaaaggatt gatgaaaaga attttaatgt gatttggact 547201 atttcccgaa aaaagcggct ccatttaggg agccgctttt ttatgctttt tcagtttttg 547261 tcataaacag gtagagcccg taatctgtcg gtgcggatgc gtagcctgcc tgccgcagca 547321 ttgctgtgat attgccgcgg tggtatgtcc cgtgattgac aacgtgggga agcagttcgg 547381 aaacagttgt tttcatgatt ccgcttgagg gattttgaat ctggagtggc ttattgagct 547441 gttctttttg ctgtaaaaat agtatatagc gctcggataa cctcagaaaa aggtcttcca 547501 tttcctctat ttctttagcc tctgtctgtt ctttaagctg ttcagctaaa gccaacgcat 547561 cgctcaaggt tttgccggaa aacacttcaa tccagccgag atcagaaaga taaacatgag 547621 acaatacatg ggatattgac ggaaacacgc tttgaatttc ttgatggtat atctcttttg 547681 gaagctcttt taatcggttg aatatttgtt gattggccca gacgttatat tcatacaatt 547741 tgaatgcaaa atctgacatg ttaaaattcc ccctttcgtg tgtatagctt tcattataca 547801 cgaacatgag ttcttatgta gagtgctcga aaataaaatt tgttgacata tatagtttag 547861 aggaataaac taattgacat tgaacataaa gtttagcggg gtaaactata atgcgtctga 547921 ttagagctca tttcataaat tcttgttttt tgcagcacac ctgtcgactc aagaagcagg 547981 ttatccagca ggtcagtaat taagtttccg tggttataca cccacgaccc gttccacgga 548041 ttgccccctg catcaacagg aagggaactt tgcgctccaa taatataatg atgaggatta 548101 gcatgtttaa ccgcttcatc aagtggcgct tgatctgtac cttgactgcc gacaccttca 548161 ccgcctgatt catctaataa agcattgatt gtgttttgaa ccagttcaac gtgggcaatc 548221 tcctctaaaa aaatgccgcg aagcagatcg cggtactgtt tctgctttcc tctgaaatta 548281 gagctttgga aaaaaactgc atcattgtac gcatttctcc gtaatgaccg cctaatatct 548341 cctgcaggac cttagcagct gccgggtctg gcttgtccgg tttaatgata ttaatcagtt 548401 cctctttgta gtaatacata acacgcctca tttcttctta agagattttc ttatattatt 548461 tgtaagatga gataaaatat atacatgata agcatgggaa ggcgtgaaag aagaaaataa 548521 aaaaatacag gaaaagtgtt gaccaaataa aacaggcatg gtatattatt aaacgtcgct 548581 gatgaacagc gtgaaacaaa acagaaaaac aaaaaagttt tcctaaggtg tttacaagat 548641 tttaaaaatg tgtataataa gaaaagtcga attgaaaaag attcgaaaaa acattaaaaa 548701 acttcttgac ttcaacatca aatgatagta tgatagttaa gtcgctcaat aagcgcccgt 548761 agctcaattg gatagagcgt ttgactacgg atcaaaaggt taggggttcg actcctctcg 548821 ggcgcgccat ataagatacc acgcgggtgt agtttagtgg taaaacctca gccttccaag 548881 ctgatgtcgt gagttcgatt ctcatcaccc gctccattat tgaatgatct ttgaaaacta 548941 aacaagacaa aacgtacctg ttaattcagt ttttgaaaat cgcacagcga tgtgcgtagt 549001 cagtcaaact agggcctgca cgatgcaggt cacacaggtg tcaccgcggg atgcggtgga 549061 cttaacctgt gatccattta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc 549121 gtgcctaata catgcaagtc gagcgaacag atgggagctt gctccctgat gttagcggcg 549181 gacgggtgag taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg 549241 ggctaatacc ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta 549301 ccacttacag atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc 549361 aacgatgcgt agccgacctg agagggtgat cggccacact gggactgaga cacggcccag 549421 actcctacgg gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa 549481 cgccgcgtga gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt 549541 accgttcgaa tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt 549601 gccagcagcc gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg 549661 gctcgcaggc ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat 549721 tggaaactgg gaaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa 549781 tgcgtagaga tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc 549841 tgaggagcga aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa 549901 cgatgagtgc taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc 549961 actccgcctg gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca 550021 caagcggtgg agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac 550081 atcctctgac aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca 550141 tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct 550201 tgatcttagt tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga 550261 ggaaggtggg gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta 550321 caatggacag aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc 550381 tcagttcgga tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg 550441 atcagcatgc cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga 550501 gagtttgtaa cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg 550561 acagatgatt ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac 550621 ctcctttcta aggatattat acggaatata agaccttggg tcttataaac agaacgttcc 550681 ctgtcttgtt tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa 550741 cagtagacat cacattcaat tagtaataca agatatcaca tagtgattct ttttaacggt 550801 taagttagaa agggcgcacg gtggatgcct tggcactagg agccgatgaa ggacgggacg 550861 aacaccgata tgcttcgggg agctgtaagc aagctttgat ccggagattt ccgaatgggg 550921 aaacccacca ctcgtaatgg agtggtatcc atatctgaat tcataggata tgagaaggca 550981 gacccgggga actgaaacat ctaagtaccc ggaggaagag aaagcaaatg cgattccctg 551041 agtagcggcg agcgaaacgg gattagccca aaccaagagg cttgcctctt ggggttgtag 551101 gacactctgt acggagttac aaaggaacga ggtagatgaa gaggtctgga aaggcccgcc 551161 ataggaggta acagccctgt agtcaaaact tcgttctctc ctgagtggat cctgagtacg 551221 gcggaacacg tgaaattccg tcggaatccg ggaggaccat ctcccaaggc taaatactcc 551281 ctagtgaccg atagtgaacc agtaccgtga gggaaaggtg aaaagcaccc cggaagggga 551341 gtgaaagaga tcctgaaacc gtgtgcctac aagtagtcag agcccgttaa cgggtgatgg 551401 cgtgcctttt gtagaatgaa ccggcgagtt acgatcccgt gcaaggttaa gcagaagatg 551461 cggagccgca gcgaaagcga gtctgaatag ggcgcatgag tacgtggtcg tagacccgaa 551521 accaggtgat ctacccatgt ccagggtgaa gttcaggtaa cactgaatgg aggcccgaac 551581 ccacgcacgt tgaaaagtgc ggggatgagg tgtgggtagg ggtgaaatgc caatcgaacc 551641 tggagatagc tggttctctc cgaaatagct ttagggctag cctcaaggta agagtcttgg 551701 aggtagagca ctgattggac taggggcccc taccgggtta ccgaattcag tcaaactccg 551761 aatgccaatg acttatcctt gggagtcaga ctgcgagtga taagatccgt agtcgaaagg 551821 gaaacagccc agaccgccag ctaaggtccc aaagtatacg ttaagtggaa aaggatgtgg 551881 agttgcttag acaaccagga tgttggctta gaagcagcca ccatttaaag agtgcgtaat 551941 agctcactgg tcgagtgact ctgcgccgaa aatgtaccgg ggctaaacgt atcaccgaag 552001 ctgcggactg ttcttcgaac agtggtagga gagcgttcta agggctgtga agccagaccg 552061 gaaggactgg tggagcgctt agaagtgaga atgccggtat gagtagcgaa agaggggtga 552121 gaatcccctc caccgaatgc ctaaggtttc ctgaggaagg ctcgtccgct cagggttagt 552181 cgggacctaa gccgaggccg aaaggcgtag gcgatggaca acaggttgat attcctgtac 552241 cacctcctca ccatttgagc aatgggggga cgcaggagga tagggtaagc gcggtattgg 552301 atatccgcgt ccaagcagtt aggctgggaa ataggcaaat ccgtttccca taaggctgag 552361 ctgtgatggc gagcgaaata tagtagcgaa gttcctgatt ccacactgcc aagaaaagcc 552421 tctagcgagg tgagaggtgc ccgtaccgca aaccgacaca ggtaggcgag gagagaatcc 552481 taaggtgatc gagagaactc tcgttaagga actcggcaaa atgaccccgt aacttcggga 552541 gaaggggtgc tctgttaggg tgcaagcccg agagagccgc agtgaatagg cccaggcgac 552601 tgtttagcaa aaacacaggt ctctgcgaag ccgtaaggcg aagtataggg gctgacgcct 552661 gcccggtgct ggaaggttaa gaggagcgct tagcgtaagc gaaggtgcga attgaagccc 552721 cagtaaacgg cggccgtaac tataacggtc ctaaggtagc gaaattcctt gtcgggtaag 552781 ttccgacccg cacgaaaggc gcaacgatct gggcactgtc tcaacgagag actcggtgaa 552841 attatagtac ctgtgaagat gcaggttacc cgcgacagga cggaaagacc ccgtggagct 552901 ttactgcagc ctgatattga atgttggtac agcttgtaca ggataggtag gagccttgga 552961 aaccggagcg ccagcttcgg tggaggcatc ggtgggatac taccctggct gtattgacct 553021 tctaacccgc cgcccttatc gggcggggag acagtgtcag gtgggcagtt tgactggggc 553081 ggtcgcctcc taaaaggtaa cggaggcgcc caaaggttcc ctcagaatgg ttggaaatca 553141 ttcgcagagt gtaaaggcac aagggagctt gactgcgaga cctacaagtc gagcagggac 553201 gaaagtcggg cttagtgatc cggtggttcc gcatggaagg gccatcgctc aacggataaa 553261 agctaccccg gggataacag gcttatctcc cccaagagtc cacatcgacg gggaggtttg 553321 gcacctcgat gtcggctcat cgcatcctgg ggctgtagtc ggtcccaagg gttgggctgt 553381 tcgcccatta aagcggtacg cgagctgggt tcagaacgtc gtgagacagt tcggtcccta 553441 tccgtcgcgg gcgcaggaaa tttgagagga gctgtcctta gtacgagagg accgggatgg 553501 acgcaccgct ggtgtaccag ttgttctgcc aagggcatcg ctgggtagct atgtgcggac 553561 gggataagtg ctgaaagcat ctaagcatga agcccccctc aagatgagat ttcccattcc 553621 gcaaggaagt aagatccctg aaagatgatc aggttgatag gtctgaggtg gaagtgtggc 553681 gacacatgga gctgacagat actaatcgat cgaggactta accatatttt tgaatgatgt 553741 cacacctgtt atctagtttt gagagaacac tctcaatttg tttggtggcg atagcgaaga 553801 ggtcacaccc gttcccatac cgaacacgga agttaagctc ttcagcgccg atggtagtcg 553861 ggggtttccc cctgtgagag taggacgccg ccaagcatta cttttatcat cgcggggtgg 553921 agcagttcgg tagctcgtcg ggctcataac ccgaaggtcg caggttcaaa tcctgccccc 553981 gcaaccaaat atatggttaa ataaggagtg ccctaagggt gcaaccaaaa taatcctata 554041 caaatatggt ccggtagttc agttggttag aatgcctgcc tgtcacgcag gaggtcgcgg 554101 gttcgagtcc cgtccggacc gccattaatg taaacgaaac gatcatgttt tcgttttttt 554161 tgtgttttct tttactgtat cttctgcttg gtgtcatagc caagctttct ttatatcggg 554221 aacatcttgg atattccagc aaaattcgat aaactaggaa gagcacaaat aggcataagc 554281 agggttgaaa ggaggttttg gttcatggat gaatttgatt tgatacatag cattactccg 554341 cggaccattc accattcttc cgttgatgta ggaataggtg atgatgcagc gctctacact 554401 gcgaaacacg gcgttcagga aattgtttgt gttgatacta tggtagaaga cgtgcacttc 554461 aaattacact attcctcacc tgaagatatc gggtacaagg cgttagccgt taatataagt 554521 gatattgccg cgatgggagg cattcctaag ttttatctgg tatcacttgc ggtaccttca 554581 aaatggactg aatctgaaat caaggcgatg tatgaaggaa tgaatgaact ggcgaaacta 554641 tatcatatgg atctgattgg cggcgataca gtttctaccg ctgacaaatt agtcgttaca 554701 gtcactgtaa tcggtgaaat tgaaaaggga caggcctgtt tgcgcagctt ggcaaaaccg 554761 aatgatattg tgtttgtaac cggtgaaatc ggttcttctg cagcagggct ttctttattg 554821 ctggaagaga ctaatcctca aaactcatct gtggaaacgg attactttat ccacaggcat 554881 aaacggcctg agccaagagt aagcgtcggc agattatgct cgatttttaa acgggcagct 554941 ttaaatgatg ttagtgacgg attggctagt gaactgaacg agattgcaga agccagctgt 555001 gtttcaattg aaattgttga aagcatgctt ccaattcatt ctgatttgcc taagcttcat 555061 cctaactgga aagaatgggc tttgtttggc ggtgaggatt ttgagctgac agggacggtt 555121 tcaaatgagg agtgggaagt gttgaagcag gagtgcgcag cgcttcatct tcccattaca 555181 aagattggct atgtcaggga aaaaacaaaa tctaaagtga tcctaaaaac agatcaaaca 555241 tcaatgatct tagagaaaaa gggatataat cattttaaat aagacgggtg actcgtgtga 555301 agcaattaaa atggagaact gtaaatccag aagaaacaaa agcaattgcc aagctgacgg 555361 cagcgtttgc taaaccggga gacgtcctga cattagaggg cgatttaggt gcaggaaaaa 555421 cgacttttac gaaaggtttt gcagaagggc tgggaattac acgtattgta aacagtccga 555481 cttttacaat tataaaagaa tataacgatg gcgtacttcc tctttatcac atggatgtgt 555541 atagaatgga agatgaaagt gaagatttgg gacttgatga atattttcac ggacaaggtg 555601 tctgtctcgt tgaatgggct catttaattg aagaacagct gccacaggag cgactgcaaa 555661 ttgtcatcaa aagagctggt gatgatgagc gggaaattac ctttactgct gtcgggaatc 555721 ggtatgaaat gctttgtgag gagttaagta gacatgacaa tattagcaat tgatacatca 555781 aattatacat tgggcattgc gctgcttcga gaagacactg ttatagcaga atacattaca 555841 tatttgaaaa agaaccactc tgtaagagcg atgcctgctg ttcattcatt gctgaatgat 555901 tgtgatatgg caccgcagga cctttctaaa attgtcgttg caaaaggccc tggttcatac 555961 acaggagtaa gaataggtgt gacgttggcc aaaacacttg cctggtcttt agacattcca 556021 ataagtgctg tatcaagtct tgagacgctt gcggcaaatg gccggcattt tgacggtctg 556081 atcagcccaa tctttgatgc tagacgggga caggtgtaca caggtctgta tcaatataaa 556141 aatgggcttt tagagcaagt tgttccagat caaaatgtga tgctggcaga ttggctggag 556201 atgctaaaag aaaaggaccg ccctgttttg tttttaggcc atgatacttc tcttcacaag 556261 cagatgatcg aggatgtgct tggaacaaaa ggattcattg gaactgccgc ccagcataac 556321 ccgcgccctt cagaattggc ttttctcggg aaggaaaagg aagcagctga tgttcatggg 556381 cttgtcccgg attacttgcg gctggcagaa gctgaagcga aatggattga aagtcaaaag 556441 tagggtgata ggatgaaaac aaaagcagcg gtcagaaata tgcggcttga agatatagat 556501 cacgtatacg aaatcgaagc atcctccttt acgtctcctt ggacgaagga ttcgttttat 556561 catgagctgc tggaaaatcc gtatgctcat tatctcgtga ttgaaaagga cggccatctt 556621 gctgggtatt gcgggatttg gattgtgatg gacgatgccc agattacaaa tatagcgata 556681 aaaccagagt atcgcggcca gtctttagga gaaacgcttt ttcgctcagc tgttgaactg 556741 tgcaaagaaa aagacgcaag gcggctttcg cttgaagtga gggtttcgaa tcatcctgct 556801 caaggcttat ataagaaatt cgggatgcag cccggcggaa taagaaagaa ctattatact 556861 gataacgggg aagatgcgtt aattatgtgg gtgacgataa atgagtgagc aaaaagacat 556921 gtacgtatta ggaattgaaa caagctgtga tgagactgct gcagctattg tgaaaaacgg 556981 gaaagagatc atttcaaacg tagtagcctc tcaaattgaa agccataagc gcttcggagg 557041 cgttgttccg gaaattgctt caagacatca tgttgaacaa atcactttgg ttatagaaga 557101 ggcgtttcgc aaagctggca tgacgtatag tgatattgat gcgattgcag taacagaagg 557161 tccgggactg gtgggagcgc ttcttatcgg agtgaatgcc gctaaagcat tgagctttgc 557221 atataacatt ccgttagtag gcgttcatca tatagccggt catatatacg cgaaccgtct 557281 tgtagaagac atcgtgttcc cggcactggc attggtcgtt tcaggaggcc atacagaact 557341 ggtttatatg aaggaacatg gatcatttga agtcattggg gaaacccttg atgatgcggc 557401 aggagaagcc tacgacaaag tggcgcggac gatgggattg ccatatccgg gtggaccgca 557461 aattgacaag ctagctgaaa aagggaatga caatattccg cttcctcgcg catggcttga 557521 agaaggctct tacaacttca gctttagcgg attgaagtct gcggtgatca atacgcttca 557581 taatgcatcc caaaaagggc aagagattgc tccggaagat ttgtctgcca gtttccaaaa 557641 tagtgtgatc gatgtcttgg taaccaaaac ggcgcgcgcg gcaaaggaat atgatgtcaa 557701 acaggtcctt ttagccggag gagtagctgc aaacagaggc ctcagagctg cattagaaaa 557761 ggaatttgcc cagcatgaag ggattacgct tgtcattcct ccattagctt tatgcacgga 557821 taatgctgcg atgattgctg ctgctggtac aattgctttt gaaaaaggaa ttcgcggtgc 557881 atatgatatg aatggccagc ccggccttga attgacttct tatcaaagtc tcacgagata 557941 atagcgtgag actttttatc tgtttgttat taacagacaa ttcacaattt atccacatat 558001 ctgtgagtaa ttatagagat attgatggat aaagggctga ggtcactgtt aataaagtgg 558061 ataaattcag aatattttgt ggatagtgtg tataaagcgc ttactttgtt tatttattag 558121 gggatgttct gtggataaaa agcacctcta aaaagaggtg cttgactttt ttaatcttct 558181 tctgtggata gttcttccca ttcggacaaa agagattcca gctcctgatt aagcttctca 558241 ttgtctgcat ggatagcttg tactttttca tgatcctgat agacttcagg gtcacatagc 558301 aattcatcat tgcggctgat gttctcctca atggtttgaa cggtggtttc aatttcttca 558361 atccgacgga gtcgttggcg ctctttcttt ttccattctt tttcttcctc gtaggaacgt 558421 ttggagtcag acttcactgt agctggcgtt ttatcagttt cctcttgctg attcattttc 558481 tccaattcaa gctgctctgt ttttttctct gtataataat cgtaatctcc cagatactcc 558541 tctatatggc ttgaagaaag ctccaatact cttgtggcga ttctgttaat aaaatatctg 558601 tcatgtgaga caaataacag tgtgcctgga taatcaatca gcgcgttttc gagaacttct 558661 ttgctgtcta aatccagatg gttcgtcggt tcatcaagga tgagaaagtt ggctttttga 558721 agcatcagct tagctagagc caatcttgct ttttcgcctc cgctcagtga atgaactggt 558781 ttcagcacat catctccgga gaataagaaa tttccgagac acgttctgat ttctttttct 558841 gggagcccgg ggtactcgtc ccacagctca tcaaggacac gtttagagga agtcaactca 558901 gcctgttcct ggtcataata gccgacactg acatttgagc cgtaagaaat tgttccctga 558961 tctggtttta gggtgtctat taatgttttc agcaatgtcg atttacctat tccgttaggg 559021 ccgacaagcg cagcgctttc tcctcttgtg agcatgaatg acacttctgt taaaagcggc 559081 ggctggtttt catagctgat tgtgagatcc tgaacacgaa ggacttcatt tccgctctgt 559141 tttgtaatat caaaatgaaa gtttgcggat ttttcatcgc caagcggttt tgacatgaca 559201 tccattcgct caagctgctt tctgcggctt tgcgcccttt tggtggtaga ggctctcgcc 559261 agatttcgat ctacgaagtc ctgcagcttt gcaatctcgt cctgctgctt ttcatacatt 559321 ttcagatctt tttcatactg cgcggctttt tggtcgagat aagcgctgta gttgccgtga 559381 tactttttgc tttctgctct tgatacctcg tatacctggt ttactacttt gtccaaaaag 559441 tagcggtcat gcgaaacgat gagaatggcg cctgaatagc cttgtaaata atgctcaagc 559501 caggtaagcg tatcaatatc cagatggttt gtcggctcat caagaatgag caaatcaggc 559561 tgtgttaata gaagcttacc taaagccagt cttgttttct ggcctccgct gaggctttga 559621 acctgtgtag aatcgtcaaa atggctgaag ccgagaccat gcagcacaga tctaacatcc 559681 gcttcatatt gataaccgcc tttatctttg aattcctgct gaagacggtc gtaggttttc 559741 atgatgcttt ctaattcacc cgggtcagct gccgccattt tttcttccat agcccgcatt 559801 tccttttcca ttgcttttaa gtggtcaaaa acagtcagca gctcttcttt tatggtaagc 559861 ttagaatcca agccagtatg ctgggcgaga tatcccattg taatatcttt cggtttaata 559921 atttcgccct tttcatacga aagctggcct gcgataattt taaggagcgt ggattttccg 559981 gcgccatttc ttcctacaat ggcgatgcga tcacgatttc tgacttccag ctttatattg 560041 tttaaaatag tatcagcacc aaatgatttg gacagctgat taacttgtaa gatcatcata 560101 ttatttcacc tctgctataa taagttaagt gtagcttatg aaccagaagt cagcaaacaa 560161 tacattggcc atataagaca tagagaagaa aatagtgtat gatctgttta aggagcgttt 560221 taatatgaat ggattttctc attttaatga acagggcaga gcccagatgg tggatattag 560281 cgaaaaatct tcgactgtcc gtactgcggc ggctgtttca agcgtacaca tgaagaatga 560341 agtgtacgag aaaatacaaa gtcacgatat cggcaaagga gatgtactgg ctgtcgcaca 560401 ggtggcaggc attatggccg caaagcaaac gtcgaatatc attccgatgt gccatccgct 560461 ttcattgagc ggggtagata tatcgtttga ctggaaaata aaagaagcag aagttatact 560521 tcatataaaa gcacaggtca aaacgaaagg gagtacaggt gtggaaatgg aagcgctcac 560581 ttctgcatcg gtgtgcgctc ttaccgttta cgatatgtgc aaggcccttg ataagggaat 560641 ggtcatcggc cctactttct tgctggagaa gacaggcggg aaaaacggtg actttaaaag 560701 agaactatcc gagtataatt tggaggacca aaaatgaata aggatcaatc aaaaattccg 560761 caggcgacgg cgaaacggct gccgctttac tatcgctttt taaagaatct gcatgcgtca 560821 ggaaaacagc gtgtatcatc cgctgaactc agtgatgccg taaaggttga ttctgccacg 560881 attcggaggg atttttccta ttttggagct cttggcaaaa aaggatacgg atataatgtg 560941 gattatttgc tgtctttttt ccggaaaacg cttgatcagg atgagatgac agacgtcatc 561001 ttgattggtg tcgggaactt gggaacggca tttcttcact ataatttcac aaaaaacaat 561061 aacacaaaaa tttctatggc ttttgatata aatgagagta aaataggaac tgaggtaggc 561121 ggcgtgcccg tctataacct tgatgacctt gaacaacacg taaaagatga atcagttgcc 561181 attcttacag tgccagcagt tgccgctcaa tccattacag acagattggt cgcattagga 561241 atcaagggaa tccttaattt tacgccggcc cgtttgaatg tgccggaaca cattcgaatt 561301 catcatatag atttagcagt tgagcttcag tcactggttt attttttgaa gcattattca 561361 gttttagagg aaatcgaata gagggaaagg aggagcccaa atatgccgat cggtcctgga 561421 agccttgctg ttatcgcaat cgttgctctg attatcttcg gtcccaaaaa gctgcctgaa 561481 ttggggaaag cagcgggaga cacacttcgt gaatttaaaa acgctactaa aggattaacg 561541 agtgatgaag aggaaaaaaa gaaagaagat cagtaagtta ggatgacacg aatgaaagtg 561601 aatcaaatgt cgctgctgga gcatattgct gagcttcgaa aacggttgct gattgtagcg 561661 ctggcgtttg tcgttttctt tattgctgga ttttttttag caaagccgat tattgtgtat 561721 ctgcaagaaa cagatgaagc gaagcagctt acgcttaacg cgtttaacct gacagacccg 561781 ctttatgtgt ttatgcaatt tgcgtttatc atcggcatag tcttgacctc gccggttatt 561841 ctttatcagc tttgggcttt tgtgagcccg ggcctctatg agaaagagcg caaagtaacg 561901 ctcagctaca ttccggtctc tattttgctg tttttagcgg gcttatcttt ttcatattat 561961 attttatttc cttttgttgt tgattttatg aagcggattt ctcaggactt gaatgtcaat 562021 caggtgatcg gaattaatga atattttcat tttcttctgc agctgacgat tccgtttgga 562081 ctgctgttcc aaatgccggt catcctcatg tttttgacaa ggctcggaat tgtgacaccg 562141 atgttcttgg cgaaaatcag aaagtatgcg tattttacgc tgctggtgat cgcagccctg 562201 attacaccgc ctgagcttct gtcccatatg atggtcacag tcccgctttt gattttatat 562261 gaaatcagta tccttatatc gaaggccgct tatcggaaag cacagaaaag cagtgctgcc 562321 gatcgggacg tgtcttctgg gcaataataa aaaatccatt tctcatgcga gaaatggatt 562381 ttctttattt ttggttcttt ttgattttaa atgaaaaggc gaacatctta aaagaaatgc 562441 tgatgttgta agcggcgaac accatcagca ggatggagta aaatgaccac atgctgcctg 562501 gcgagcttgc ggcaagataa gtaaagatgc accctacggc aaagtagatc attccccaaa 562561 ctaccgggtt tctcataaaa ataatcctcc aataatcaat tgcatttgtg tgctctgctg 562621 ttcaaggtaa ttacgaacag gctcaagctg catgatgacg acgaatgtat tcatcattaa 562681 atgggcgaaa atcggcaccc atatccgttt tgttctcgca tataaaaagg caaaggtaaa 562741 gcccattgct gtatatagaa ggagatgctt caaatcagcg tgaacaatac cgaagataac 562801 cgagctgatc agtcctgcga aaaagaaatt cgttttttcg tacagcgcgc cgaaaatgat 562861 ttttctgaag atgatttctt ctaatatagg cccgacgatg gaagaaacga taatcatgag 562921 cgggactgcc tgaatgacat ccagaatcgc ttgtgtattt tctgattctc ttccgatgcc 562981 aaaaacataa tattcaatag agcctgctat tccttgagag aaaagggcaa tgaaaaaacc 563041 ggctatcgcc caaaggatag aaagtccgat tgagtccttc tgtccgtttc gcagcgtttc 563101 tttcggaacg gttctcagaa tgagcagaac aacaacgaga caggcgataa agctgataac 563161 ggaccataat ccttgtgcat gcagcatatt ttcatctgta ggctgtcctc cggcataacc 563221 gaatttaaat aacaagggaa tcgcgattaa tgcggaaaac tgcatgatga tatatgtcaa 563281 aataataaac caatactgtt ttctcaaatg gtatgtactc ctttgttaag tgggtttcgt 563341 tcatctacag ctattgtaac ataatcggta cgggggtgaa aaagctaacg gaaaagggag 563401 cggaaaagaa tgatgtaagc gtgaaaaatt ttttatctta tcacttgaaa ttggaaggga 563461 gattctttat tataagaatt gtgttagcac tctttagtgc tgagtgctaa aattacatat 563521 tcatactatt gaggaggtta tttcattgtt aaagccatta ggtgatcgcg ttgtcattga 563581 actcgtagaa tctgaagaaa aaactgccag cggaattgtg ttgccggatt ctgcaaaaga 563641 aaaaccgcaa gaaggcaaaa tcgtggcagc tggttcaggt cgcgtgttag aaagcggaga 563701 gcgcgttgct ttagaagtaa aagagggcga ccgcattatc ttctcaaaat acgcaggtac 563761 tgaagtgaaa tacgaaggta ctgaatactt aatcttacgt gaaagcgaca ttttagctgt 563821 tatcggctaa ttcttaaata aacaatactt aaaacatttg aggaggtctt gtaaacatgg 563881 caaaagaaat taagtttagt gaagaagctc gccgcgcaat gcttcgcggt gtcgatgcac 563941 ttgctgatgc tgttaaagta actttaggac caaaaggacg caacgtggtt ctagagaaaa 564001 aattcggttc tccgttaatc acaaatgacg gtgtaacaat cgctaaagaa atcgagctag 564061 aagacgcgtt tgaaaacatg ggtgctaagc ttgttgctga agtagccagc aaaacaaacg 564121 acgttgccgg tgacggtaca acaactgcaa cagttcttgc gcaagcaatg atccgtgaag 564181 gccttaaaaa cgtaacagca ggcgctaacc ctgtaggcgt gcgtaaaggg atggaacaag 564241 ctgtagcggt tgcgatcgaa aacttaaaag aaatttctaa gccaatcgaa ggcaaagagt 564301 ctatcgctca ggttgctgcg atctctgctg ctgatgagga agtcggaagc cttatcgctg 564361 aagcaatgga gcgcgtagga aacgacggcg ttatcacaat cgaagagtct aaaggcttca 564421 caactgagct tgaagttgtt gaaggtatgc aattcgaccg cggatatgcg tctccttaca 564481 tggtaactga ctctgataag atggaagcgg ttcttgacaa tccttacatc ttaatcacag 564541 acaaaaaaat cacaaacatt caagaaatcc ttcctgtgct tgagcaggtt gttcagcaag 564601 gcaaaccatt gcttctgatc gctgaggatg ttgaaggcga agcacttgct acacttgttg 564661 tgaacaaact tcgcggcaca ttcaacgcag tggctgttaa agctcctggt ttcggtgatc 564721 gccgtaaagc aatgcttgaa gacatcgctg tccttactgg cggagaagtc atcacagaag 564781 atcttggcct tgacctgaaa tctactcaaa tcgctcaatt gggacgcgct tctaaagttg 564841 tcgttactaa agaaaacaca acaatcgttg aaggcgctgg cgaaacagac aaaatttctg 564901 cccgtgtgac tcaaatccgc gctcaagtgg aagaaacaac ttctgaattc gacagagaaa 564961 aattacaaga gcgtcttgct aaacttgctg gcggcgtagc tgtcatcaaa gtcggcgctg 565021 cgactgaaac tgagctgaaa gagcgtaaac ttcgcatcga agacgccttg aactcaactc 565081 gcgcagctgt tgaagaaggc atcgtatccg gtggtggtac agcgcttgta aacgtatata 565141 acaaagtcgc tgcagttgaa gctgaaggcg atgctcaaac aggtatcaac atcgtgcttc 565201 gcgcgcttga agagccaatc cgtcaaatcg cacacaacgc tggccttgaa ggatctgtca 565261 tcgttgagcg cctcaaaaac gaagaaatcg gcgtaggctt caacgctgca actggcgaat 565321 gggtaaacat gatcgaaaaa ggtatcgttg acccaacaaa agttacacgc tcagctcttc 565381 aaaacgctgc gtctgtagct gcaatgttct taacaacaga agctgttgtc gctgacaagc 565441 cagaagaaaa cggtggcggc gcaggaatgc ctgatatggg cggcatgggc ggtatgggtg 565501 gaatgatgta ataaagggat attaaccctt atacatcaat gttttaaccg tcttaaaaaa 565561 ctagacaaag cgtgaataaa aaaagagaag gtctttcatc agtttactaa actgttggga 565621 gaccttttct ccatattagc ggtcatatga gcataaatgt ccatcgtcgt atttatgtcc 565681 gaatgaccaa attgttgctg gatttcttta atgcctactc ctgcctcaat tagtaaggag 565741 gtatgggtat gcctaaaaga gtggggggtg acattctttt tatcccagct tttttgagca 565801 gccgtttaag tctagtctca ataacctttc ttaattgcgg atgaccatcc tcccgctcaa 565861 aaataaatga tgagtcttga taaatcaatc tatttttaag cttaatttca ttttgataaa 565921 ttttattttt ttttagtaga ttgacatcgt ttcatcaatt cgaacgatat caacagatcc 565981 tgttgtttta ggtgttagca attggtattt ttcaatttga ttgttagggg tgtatagggt 566041 ctttgtgacc tggcttatca ttgaaatctg tccattttaa agcaagaagt tcaccaattc 566101 ttaggtcggt ctaggcaagt acggtaaaga ccaaatggtc catttctagc ccgtcagatt 566161 gagcgagctt tagaaaatgt gtcagcacct ctttttccaa tgctttgttg cttcttgggt 566221 aattgaaaat ccccagttgg gttcatttta ataatccctt gagttttagc ttttcggaaa 566281 atcatacggc cgcaggcatg aatacctccc aaacaattgt gactgtattg ctcgttcagt 566341 tctaacgtgc ggtcttcata catttttttg tgttttgcta atcgggtatt gacccaatac 566401 tgcgataaaa tgcatcattt tcttttcact ggcccgtaca ctgcttattt ttaccccact 566461 ccggttgtaa atcttaagcc aaccttttgc aaatgttttg aagggcatat ctgactcctt 566521 aataaaagtc ccgttgtcgt tttggagttc tacgtgacgg gctgctactg gggcttcttt 566581 ctttgtttta aatcttcctt tggatatttc tagacgtttt ttggttaaag ggtcaatgcc 566641 tagtagatat gataactcca cgtcttaccg cattgcttga gttttgccat ttatttgtcc 566701 ctaactaatt ttttttcatc aaattggtct ttaagtgagt ttaataattt ttgtttctct 566761 cgactggtca ataattgccc ttcatatttc aaaagattgg ataaatttga gatggaatca 566821 atcctgatgg atggtaccgt agactttaat aagaaacgaa aggccaactg cgacttcagt 566881 tggcctttcc tatttataat aaagaaattg agtgagattg ctgacagaac tacgtactac 566941 tcgttttctt tagttgccct tgctaatcgt tcaacctctc cccgaatccc aatcgcaggc 567001 tcccacgaat caatcaaacg aatcgccttc tgattagatt ccaccgcttt cgttttctct 567061 cctttacgat acaacagctg cgccattccg tagtgatagt agatcagttc aacttgattg 567121 gcgttatgtt tgtcatagag catttgctca aaggcttctt ccgctttttc aaactgatca 567181 catttcacgt aagcgacacc cagattgaaa taggcttcta tcgttttttc gccgccgtat 567241 gtggagctga tttcatttgc cgcttcgtat aattgaatgg cttctacatg ataacctctc 567301 gcaaagctta agtcaccgcg aaccaataga actctgtgtt gaatggtagg ggaaatcggt 567361 tgattttcga tttcgtttaa aattgtctct gctttttcct gttgcccgtc ttttaaaaac 567421 agccttgctt tgagtgcatg tccccaaacc tttagatcat aggcatcgtg agcgtctgat 567481 tgttcaagaa tcttcagccc ggcttctatt tgctgaagcg ctccgtctaa atcattgact 567541 tccatcaatg cccagcctga ggtgtcgatt cggaagtacg cttctcgtgt gtgttggcct 567601 aagtgatggg cggcgtcggc cgctttgcgt ccgtattcga ttcgcagggg caggttgatt 567661 ctgcttagaa aatggctaat gcgggtgatg agttcgatta ggatttcttt ttgttcagtt 567721 tcacttgccc attggatgac ctttaagatg tttggccatt cttgtttcat ttgatctaag 567781 ttccgtccca gcaggtagct ccaatagata gagttgggct gttcccgctt taaatgggtt 567841 tcggcataat caatataata gtgcgcccag cgattgcggg cttctttttc atattcgtgc 567901 tgttcggaca agtgctgttc tccgtaagcg acaacggttt ggtgcgctaa gtattgtgtc 567961 ctgccttggc ttcgttccgg ctgaatcagc gcatatgacc gcatttgttc catagcgtaa 568021 tgaaaacggc gggcgtctaa tccggctgct gccgccaggc ttttttcatc aggcggcttg 568081 ctgaaaaagc aaagcgtctg ccagagcttt cgcgtatctt cattgcatct atcccaggtg 568141 cggccaaaga ggaattcaaa caattccagc agtgagtagc ctgcttttcc aagctcatga 568201 atcagctgct gagcggggat gtcatcgtct gacatatagg caatgctgag tgccatggct 568261 ttcgggtttc cggcagtcgc tgaaatgaat tcgtttttca ggtcagatga tagatgtaac 568321 agctgctcca gcttttcccg tttacgtggg aggttgcatg tttgtaagca gtgatgcact 568381 tcttgttgaa aaaattcgtg ggcatctgtt tggtcaagac cgcttagctg aatggctgtc 568441 atttctccga agctttcccg ataagtttgc tttacgtttt cccgcgctgt aaggagaact 568501 tttacgcctt gcggaaggct ggtgataaat tcatgaatgt cacgttctgc agtatcaatg 568561 ctgtcaacga tcagcaggat cggtttttct ctagtgtaat tggctaacgc attgcggacg 568621 acaaaccgtt ttacattgat tgatttatcg atttgttctt tgcgtccgag ctgataggcg 568681 atcgtattta aaaaatcgct aaagcttaat cctttccaat cagcgctgac ccagatgatg 568741 ctgttgaatg ccggccaaac tgaagtatcg tcgacacagg aataggcggc ttcaagagca 568801 attgtggttt ttcccatgcc ggcccagccg gtgattaaac agactggtga tggagaaagc 568861 atccattgcc gtatcgcttc catatcaaag ctgcgtccga taaagcgtcc ggaccagcgt 568921 gagggtaaat tatgcgtgat gggctgttct gtaagcgcat tcgtttcttg gccgggtctg 568981 tcatgaaaca gccgttttac tacattttca atttcgcctt cactcggagc cccgaataat 569041 ccgtcttttc gcagtatttt cgcttttttc aaacaggatg ctgcccatac aggcaatgcg 569101 ggtttgatga ctgggatagt ggtggcttcc agcaagtcgg tcaaccactc gatatccaag 569161 tcggtctttt cgagaatgat ccagatcatt ccgaacagtt ttccgtcgtc gattcttccg 569221 ggaatgtagt ttgcccccat ctgtccgatc cagcttttga tcgtgtttgg ggagactccc 569281 agctggagtg cgattttatc tatgtaagac tgtcctgttt tttcattctt tttccttctg 569341 actttataat caggatgaag ttttagcgtt ttgacgccag gtgccagcat ttgtgcaaat 569401 tgttttcggt tttcaagttc agccataagc ctgcacctcc tattagtact attttatcaa 569461 tccagcgttt tttgtatatg aaaaaataaa agtacagtgc cgctgtcctt ttatacagca 569521 ggaaaggctg ttgaacgtgt taaaaagcag ataaaatggg ggcagtaaca gagaaaacaa 569581 aaatgtatgc acttacattt tattttctaa agaaaggaac ttgccaaatg actcacacag 569641 tacctcaaaa catgaaagcg gctgttatgc acaacacaag agagatcaaa attgaaacat 569701 tgcctgtgcc tgatatcaat catgatgaag tgttgattaa ggtgatggct gtcggaattt 569761 gcggatctga tctgcattac tatacaaatg gccgaatagg caactatgtt gtggaaaaac 569821 catttatcct tgggcatgaa tgtgcgggtg aaattgccgc tgtcggatca tctgtcgatc 569881 aattcaaggt gggagaccgc gtcgctgtag agccgggtgt tacgtgcgga cgctgtgagg 569941 cgtgcaaaga aggacgctat aatctttgcc cggatgtaca gtttttggct acaccgccgg 570001 tagacggtgc gtttgtccaa tatattaaaa tgcgtcagga ctttgttttt ttaatcccag 570061 actcactttc ttatgaagaa gctgctttga tcgagccgtt ttctgtcggt atccatgcgg 570121 cggccagaac gaagctacag cccggatcaa cgattgcgat tatggggatg ggccctgttg 570181 ggttaatggc tgttgccgca gctaaagcat ttggggcagg cacaatcatt gtcaccgact 570241 tagagccgct gcggttagaa gctgcgaaaa aaatgggagc gactcacatt attaatatac 570301 gtgaacagga tgcacttgaa gagattaaaa cgatcacgaa tgatagaggc gttgatgttg 570361 cttgggaaac agcagggaat ccagcggcat tgcaatccgc actggcttct gtgcgccggg 570421 gcggaaaatt ggcgattgtc ggtttgcctt cacagaacga gattccgctc aacgtgccgt 570481 ttattgcgga taatgagatt gatatttacg ggatcttccg ttatgccaat acgtatccaa 570541 agggaatcga atttcttgct tcaggcattg tggacacgaa gcatctagta acggaccaat 570601 attcgctgga gcagacgcaa gatgcgatgg agcgggcgct tcaatttaag aatgaatgtt 570661 taaaagtgat ggtgtatcca aatcgctgag tgaacaggga ggatcttcgt attctccctc 570721 ttgtttactg gaaatgaaaa cggattcttg gggtgggaaa tgatgattgg aacagaaaaa 570781 gtaacggcat tgaaggcgaa gcatcagtca aaatccagca ccggcctgtc ctggtttgaa 570841 cgaatcggtt atggattcgg cgatatgtcg tataatatta tctttcagtt tgtaaacgca 570901 tacttattat tttattatac agacgtcggc ggcattcagc ctgcggtaat cgcaactttg 570961 tttcttgttg tgcgtgtgct ggatgctatt tttgacccga tcatgggatt gattttagat 571021 aaaacgaata caaggtgggg aaaagcaagg ccatatttgc tgtgggtggc atttcctttt 571081 gcgctattca cattcttatg tttcacgacg cctcatttcg gtgagaccgg aaatatggta 571141 tatgcgtatg tcacttatat tctgcttggg atgtccttta gtatgcaaac gatcccggtg 571201 aacagcttaa cggggcggat gacgaattcg gtggaggaac gaacggttct gaccacaacc 571261 cggatgattt tggtgtatat cggcattctt ttatccattt cctgtgcgac accgcttgca 571321 actgctatcg gaggagagga tcaggcgttt ggatttcaga tgacggcgct catctatgcg 571381 gctgtcagca tcgttttgaa tctatttagt ttctttactg tacgggagcg gattcagcct 571441 aaaaagagaa aaaaacaagg gatcaaaaag acgttatccg ttttattcaa aaacaaaccc 571501 ttgctcatgt taatttcatc atttttggct tttgcgatcg ggtttaatat taagctcagc 571561 acgatggtgt attattttac gtataacgta aaccataaag agttcgtgtt tatgggcacc 571621 gttttatttt tcggggcagc gctgatcagc aatttgttta ttcctttctt ttctgagaag 571681 tggggcagaa aacaagtcat gattatcacg gcagctctat cgcttatttc ttatgccggc 571741 ctgcatttta cgccgtattc ttcaattcca ctcattttca tttggctttt cgcttcggga 571801 tttttcacaa cgcctttaaa tacgcttgct tggggaatgg ttgcggattg cgtcgattat 571861 gcggaatgga aaaccggaat tcgcgcggat ggtgttgtga tttcgagcat gagctttatt 571921 aataagctgg gtgttgcgtt agccgggtca ttttcggcca tttatttagg aatcgccggg 571981 tatgtggcga atacagacca gacagttgcg tcgttgaatg cgattaaaaa tatgaatgct 572041 ttgattccgg gatttttcat tttgctttct attattctta tcgccttcta tcctttaacg 572101 gaaaaaagat ataaacacat catctctgag ctggagcaaa ggtctgcgag ataaatagat 572161 gtaaaatttt taatattcaa tgttgtattt atggcaaaaa gtaatatact gagactgtaa 572221 tctagacttt ataaatgagt gtgataatat gcgtagtcat tctgtagttt gtattgggga 572281 attgttgatt gatttctttt gtaccgatgt tgacgttgat ttaatggaag ggcgccaatt 572341 cctgaaaagt gccggcgggg caccggcgaa tgtgtcggca gcgattgcca agctgggcgg 572401 agacgccgct ttcagcggaa aagtaggaaa ggatccgttt gggtattttc tgaagcgaac 572461 attggacgct gtacatgtcg atacctctat gctggtgatg gatgagaaag cgcctacaac 572521 gcttgctttt gtttcattaa aacaaaatgg agagcgtgac tttgttttta atagaggcgc 572581 ggacgctttg tttacgctgg aggacattga ccaggaaaaa ctaaacgaag cgaaaatcct 572641 tcatttcggc tctgcgacgg cactgttatc ggatccgttt tgctcagcct atttacggtt 572701 gatgtcgatt gcgaaagaca atggacagtt tatttcgttt gaccctaact accgtgaaga 572761 tttatggagg ggaagagtct cagagtttgt aagtgttgcg aaaaaagcga tcgctgtaag 572821 tgattttgtg aaagtcagtg acgaggaact tgagattatc agcggtgtga aggatcatga 572881 aaagggagtt gcgatccttc atgagatcgg agccaacatt gtcgctgtga cacttgggaa 572941 aagcggaacg cttctttcca atggaaaaga ccgtgaaatc attccaagca ttccggtgac 573001 atcaattgac tcaacagggg cgggagatgc ttttgtcggt gcggctttat atcaattggc 573061 aaacacggat cagattcaat ctgtagatgc tgattttgtg aaactgcgtg agattgtggc 573121 gtttgccaat aaggtcggag ctcttgtgtg cactaaaatt ggagcgattg atgcactgcc 573181 gagtttggat gagattggag tttctttgta aatcattgaa gatgtttctt gaaagtcttt 573241 ggacttttgg gggcatcttt ttttattgct tacatttttg ttcaggtaaa aagttgtata 573301 ttttttgttt gaaatgtcat tttttattaa aaaagtgaaa cttttaacga taataaatag 573361 tatatgtaac aagggttacc gaattagctt taggaggaac gatataatga gtataattgg 573421 aagatttaaa gatattatgt ctgcgaatat caatgcttta ttggacaagg ctgaaaatcc 573481 ggagaaaatg gtagatcaat atttaagaaa tatgaatagc gatttggcta aggttaaggc 573541 agaaacagca gctgttatgg ctgaggagca gagagcaaaa agagaatatc acgaatgcca 573601 ggcggatatg gaaaagatgg aaagctatgc aatgaaggcg ctgcaagccg ggaatgagag 573661 cgatgcgaga aaatttcttg aaagaaaaac atctttggag tcaaagcttt ctgagctgca 573721 ggcggcgaat caaattgctg caaccaatgc cgcacagatg agaaagatgc atgacaaatt 573781 ggtatctgac attggagagc tggaagcacg caaaaatatg atcaaggcga agtgggcagt 573841 agcgaaaacg caagaaagaa tgaacaaact gggcgcttct gtttcaagta caagccaatc 573901 aatgtctgca ttcggccgaa tggaggacaa agtaaataag gcacttgatc aggccaatgc 573961 aatggctgaa ctgaacagcg ctccgcagga tgatatggct gatctgtctg caaagtatga 574021 cactggcggt tcaagccagg ttgatgatga acttgcggcg ttaaaagcga aaatgatgct 574081 cgataagtaa tacataggag gccgcagctt tcggctgcgg cgtcatttta tcataaaatg 574141 tgagagggaa cggtaatgat aatatcttat aagtgtccga actgcggcag tgatatggca 574201 tttgacagtg aaaccggctc gttatcctgc agcagctgcg gaagacagga caatattgaa 574261 agccttccga aagaaaacat tgcggcacgg ttttctgatg atgaagcaaa agaatatcaa 574321 tgtaaaaact gcggtgccgt tttgatcacg gaagctgaaa cgacagcaac gacgtgcagc 574381 ttctgcggag gtgctgcaat acttgccgat cgtttatcag gacatttggc gccggcgaag 574441 gtcattccat ttacaatcag caagcaagaa gcggagcagg catttcgaaa gtggtgcaaa 574501 aaaggccttc tgacaccaag aggtttcatg tctgctgatc gtatcaaaag catcaccggc 574561 atgtatattc cattttggat gtttgattta aatagtgaag tacaggtgag agcaaactgt 574621 accagagtcc atcaatatga agaaggggat tatatttgca cggaaacaga gcactttgaa 574681 gcgtttcgtg atatcaatct cgattatttg aaaatccctg tcgatgcctc tgaaaaaatg 574741 aaagacgaat taatggacaa attggagcct tattcatacg aagagctgaa ggactttcaa 574801 acggcatatt tggccggtta tattgcggaa aagtacaatt ataccgatga ggagcttttt 574861 ccgagggcaa aagagaaaat cagcagttat atagattcat acatccattc tactttttcc 574921 ggatatacgt cagtcaatgt gagggacaaa catattcaca cgaaaaacgt gaacagcttt 574981 tacgttttgc ttcctgtttg gatggtcagt tacgattatg aaagagcgga gcatatcttt 575041 gcgatgaacg ggcaaacagg aaaggtcgtt ggaaagccgc cgatcagtcg aggaaaagtg 575101 gctgcatggt ttagcggaat agcaggcggg acatttcttg cgttgaagct cgtctcattg 575161 atgatgggag gcggattttg atgcgtggat tttttgggaa agcgatcttt gttgtgctgg 575221 ctgttttcat catgatgcct ttactgggta tcgaagcggt aagagcctct gaattgcagc 575281 agcatgtgta cgatcgcgct catctattgt caaaagcgga gatcggaaaa cttgaatctc 575341 tctcggcaaa gctgggtgca aagagggaca ctgatttcat cattattacg accaaaagca 575401 caaacggtga agatattgca gactataccg gcgattttta tgatcgttac ggaaaaggca 575461 gtacagccat tctgacgatt gatatgacaa acagagaagt gtttatcgca ggctttaaaa 575521 aagccgaaca gtatttggac aacagcaggc tcaatagcat cagaaatacg atttcatctg 575581 atttatccaa tgaaaattat tttgaagctt ttgagacata tattcagctt tcctataaag 575641 atatgggcat aaaaccggga gtaaaccctg acaacatatt ctttacatgg tggtttcagc 575701 tgattgctgc catcgcagtc gggggaattg cggtttcaat catgctttat catgcaggcg 575761 gcaaagtaac ggttaatgga agtacatata tggatcagcg tacgtctgat gtgattgatc 575821 aatacgacac ttatattaga acgactgtaa caagagaaag aaaaccatca gataaagaca 575881 gcggcagcga tggcggtgtt acgaaaggcg gcacgtcata cagtgggagc cggggcagtt 575941 tttaaatgta agaaatagag aaagggagag gcgtaatgtc gtttttcaga aatcaattag 576001 cgaatgtagt agagtgggaa gaatttagag atgatatgat tttttataaa tggaacaatc 576061 gtgaaatcaa aaaagggagc cgtttaatca ttcgtcccgg acaggatgct gtctttttga 576121 acaatgggcg ggttgaagga gtctttcaag atgatggcga ttatgatatt gaatcagaaa 576181 ttattccatt cctttcaacg ttaaagggct ttaagtttgg ctttaacagc ggcatgcgag 576241 ctgaggtgct gtttgtcaat acgaaggaat ttaccgtaag atggggaaca aaacaggcga 576301 taaatattcc ggcagcggga atgccaggcg ggatgcccat tcgcgcaaac ggcacattta 576361 atttcaaggt gcaggactat atcagcctga ttgataaaat cgctggcgtg aaagatcaat 576421 attttgtaga ggatattaaa acccgtatca tttctattct ggatcagctt ctcatgaagt 576481 ggatcacaag agaagggaaa gatatgttta atcttcaagc aaacgctttt gatattgcca 576541 agggaattca agaggactta gatatgcaat taataagcga cgggatgacg gtcactggtt 576601 ttcaaatcat gagctttaat tatcctcaag aggttcaaga tatgattaca aagaacgctt 576661 cctacggtat ggttggggat gtgaacagat accagcaaat atcaatgacg gatggaatgg 576721 catccggaaa gatgagcgga agcggagcgg cttcggatat ggctggaatg atgatgggaa 576781 tgaatatggc caatcagatg atgaaccaaa tgaatcagaa tcagcaggca cagtcatcag 576841 gcccacagtc aactggcagc ggaagcaaac cgaatttctg tccaaactgc ggaacaaaaa 576901 cgggcgaagc caatttttgt ccgaattgcg gccagaagct tgtataagaa tcatacagtg 576961 aaaagtccgg agtgatcagc actcgggact tttttattta ggagaataag cattacctat 577021 tgcttgctcc tgaacaggcc attttcgagc ccccgcttgg ataattccca gcagcaattg 577081 acgacgttcc tttattgaat tgacggcaat ttgaaatgtt tgctttgata aagccggtat 577141 gcctgattgt tgaagctttg agatgtctgg ttctggcggc gcttgttctg caggatggat 577201 ataggcagta tgaacggtat ccagatagtt tttgatactt gagcgcgctt ctttgatatg 577261 aagctgattc ggctgatatt gttcaggaat tccgtatttg aaaatggtta gagcctcatc 577321 caatacagca acagctataa tggatgattc ctgatgctgc gtgctgtggt aaaaatgaag 577381 gatggggaag gcgttatgct gagcggtcag ctttcccagt tctgatgagg cagcgacaag 577441 aagaaaatca atgtcgtgaa aatctttgcc attccatgca ttatggacga tttcagttcc 577501 gtcatgccct agacttaata cactttgggc aaaggagcgt ttttgattaa ccgcactcaa 577561 gacggaaatc aaatacgtga cagaaaatgt gatggtaagc agtccttgag ctgtttcaat 577621 aatcgtgaca agcttccata ggcctccgtt cggagcgagg tcgccatttc ctaatgtaaa 577681 catgacatag ccggaaaaat aaattcggtc tgaccaggaa gccggttctt ttgattgagt 577741 ttccataagt gagtgagggt cactcgagta aatcaaaacc cacccgctcc aaaatagact 577801 gatccatatc actaacgtca ggcataacag cagaggacca gccatactta gaacctttgc 577861 gtggtcaccg ctgattttgc ggcagccctt ccacagccag gcagacaggc atcttgtgat 577921 cgggccggca ccgctctcta accataacgt ggtccataaa aaatcaatca tccccgctgt 577981 caataataaa aggcctgcaa tgatataacc ctcattcatt ttggttgcct cccttaagtc 578041 agccttcttt tattttcttc tctatttcct tttatcctga gtctgaaaca attgaacgaa 578101 tgtttgattt tacagagaaa aataggtggg agttacccaa cacttactca tttttcaata 578161 tgaacagaaa atcacaagat ttttgacttg attcacacat tttcatgaag aaaaacgttc 578221 attttcccct tgaattggtg attttccttt tatagagtaa aaaattttca gaaatttata 578281 ttgactgaaa gcgtttttat aattatgata atatcagata taacaaaaat gtcactataa 578341 catcactaca attgaactat taagtgacta ataaatacca aatgaacgag gttatgcaca 578401 aagaaatgac cattgttctt ttaacgagaa atgaaatcgc ttccataggg attgacatgc 578461 taagaagaag ggaaggttat gaggttattg gataaaaaca tgaacaacta ttttctgaag 578521 cctgcttacg aaatgtgagg aaggcagcag ccctggaata agtttttgac atacgcattt 578581 tgaaaaagac tgggggaaac agtatgaata aacaaggaaa tcaaatgtca tttttacgta 578641 caattatttt agtctccact ttcggcgggc ttctttttgg ctatgatacc ggtgtgctca 578701 atggagcttt gccgtatatg ggagagccgg atcagcttaa tctcaatgcc ttcacagaag 578761 gccttgtcac cagttcactt ctttttggag cggcactggg tgctgtgttt ggcggcagga 578821 tgtctgattt taacggccgc cgcaaaaata ttttgttcct cgctgttata ttttttattt 578881 caacgattgg gtgtacgttt gcaccaaatg ttacggtcat gattatttcc cgttttgtgc 578941 tcggtattgc ggttgggggt gcatccgtaa cggtgcctgc ctatttagca gagatgtctc 579001 ctgtggaaag caggggacgg atggtgacgc agaacgaatt gatgattgta tcaggacagc 579061 ttttggcctt tgtttttaat gcgatccttg gaacaacaat gggagacaac tcccatgtgt 579121 ggaggtttat gctggtcatt gcgtcacttc cagccttgtt cctgtttttc ggcatgatca 579181 gaatgcccga gagtccccgt tggcttgttt ctaaaggaag aaaagaagat gctttgcgtg 579241 tattgaaaaa aatcagggac gaaaaacggg cagcagctga gctgcaagaa attgaattcg 579301 ctttcaaaaa agaagaccag cttgaaaaag cgacatttaa agatctttca gtcccatggg 579361 tgcgccgtat tgtgtttatt ggattaggga ttgcgattgt acagcaaatt acaggtgtga 579421 attcgattat gtattatggg actgaaattc taagaaattc cggtttccaa acggaagccg 579481 ctttaatcgg aaatattgcg aatggcgtga tttcggtatt ggcaacattc gtcggaatct 579541 ggctgctggg aagagtgggg cgccggccga tgctgatgac aggcttgatc ggtacgacaa 579601 cagcattatt gctaatcggg atattctcac ttgtacttga aggatcaccg gcacttccgt 579661 atgtagtcct gtcattaacg gtcacatttc ttgcttttca gcagggcgcc atttcaccag 579721 tgacttggct gatgctatct gaaattttcc cgcttcgcct tcgcggactg ggaatgggtg 579781 ttacggtatt ctgtctgtgg atggtgaatt ttgcagtcag tttcacgttt ccgatattgc 579841 tggcagctat cgggctgtcc acaacgttct ttatcttcgt tggattagga atttgctctg 579901 tcttgtttgt gaagaggttt ttgccggaaa cgaaagggct ttcgcttgag cagctggagg 579961 aaaacttccg cgcttatgat cacagcgggg caaagaagga ttctggggct gaagtgattg 580021 gataatttaa aaaagaatcc gcacccgagt gcggattctt tttggtttca aattagttag 580081 gtctaacaag gattttgact tggcttttct ctttaataag agccccgaag ccttcctcga 580141 tcaaatcatc tagtacgatt tttttcgtta cgagtttgtc ggctgagaaa tagccttctt 580201 tcattaatga caatacagcc gggaagatgt cgcggtatcc gataattcct tttactgtac 580261 gttctttgat tacgatatcg ttcggatgga tttcagcacc tttttcccaa atgctgacga 580321 tgacggtttc accggcaatt gtagtggact ggatggcttg tcgtaacacc actgggacac 580381 cagtgacttc gaatgctacg tcaacaccgc ctcctgtacg ttctgcaatc tcagcgacta 580441 catcgtctgt tttagacgga tcaacgatga tcgcgccaag ctcctcagct ttttgctggc 580501 gttcaggaga aagctcaaca gcgtaaatat cagttgcacc ggcagccttc agcgcttcaa 580561 tgacaagaag tccgatcggg ccgcagccga atacagccgc tttgtcgcct gctttgagtt 580621 tgcttgagcg gacagcgtat agagcaactg cagaaggttc aacgagcgcg ccttgttcat 580681 atgataattc atcaggaagt ttgaacaaaa gctcttcatc cacagagacg tattcagaga 580741 aaccgccgcc tccgccggct aagccgagga atcccatttg ttcatcaagg ttgtaggcgc 580801 cttggtggcc gtgtgtagca aaaatcggct cgactacaac gcggtctcca actttataat 580861 tttcaacgcc ttctccgact tcgacaactt caccggagaa ttcatgcccc attgtgacag 580921 gtgccgtttc atttgttaat gggtgcggtt tgtcaaccgg aataaagatc gggccgccca 580981 gatattcgtg taaatcactt ccgcagatgc cgcaccattt gactttgatc tttacttttc 581041 ccggctccgt ttttggctct tcgatatgtt caatacggat atccttttgg ttatgccatc 581101 ttgctgcctt catggattac cactcctata acttttgatg tgagtaattc cgcaccggtc 581161 aatatgaact gttcacaaaa tcgccatttt taaaaccaaa aaagaaatga aatttttata 581221 taatataatc tacgtttttt tgaaaaaaag aaactttaaa gaaaaaaggg tctcgcacac 581281 tcttttttct ttatatgaga gtatcaatcg tttacatagc tatgaatttg gtttgaacaa 581341 tacggtaatg gttcgttcat attgaatgcg acaactactc tatcaataat tataactcta 581401 atactgctat tataatagga taatcttcca tggtttattt tagcagaggt aacttttttg 581461 actttgtaac attactgtaa ggatattgaa ataaaaaata gctggttgat cgtgtataat 581521 cttcctagat gttaacaaac agggggacga aatgttgaag aaagtcattt tagccgcttt 581581 tatcttagta ggaagtactt tgggagcttt tagtttttca tcagatgcca gtgcgaaaca 581641 tgtgaacgga aatattactt ggtataatgg agtcgggaaa aaaggctctt caggtaagaa 581701 acttggacat tgggattgtg cgaccaaaat cggatttgat gttcctagaa acgggacaaa 581761 aatcagagct tatgcaaaag cgaagcctaa aaaggtgatt acggtttata aaaatgatgt 581821 tggcagaatg cctaatgcag tgctggatgt tagccctaaa gcgtttaaag cgcttggata 581881 cccattaagc aaaggtaaag tagcggggca ttacagctat taatgtacat atataatctg 581941 gaaagcaaga agtcacattc ttgctttttc tattggtgga gataaaagat gaaaaaaaga 582001 atcatattat tattagcagt gataatagcg gcagctgccg cgggggttgc gttttatgtt 582061 gcaaaggata aaggccatga gaaggctgct gatgtttcag tcaataccga aagcggtgat 582121 gagctgctgg tttcaattac agatacggat ctgctgacaa agtattatga aaatgacaag 582181 gtgatccatg aggagaagct gaccagctat ccggcatttg ccttggatca aaaacagcag 582241 gtgctctatt atacgggcaa taatgaacag aatgaaatga ggctttttaa attggatctg 582301 aagtctcata aaaaaacgat gctttataaa ggcgcggaga gtgcggacag tttattttta 582361 tcaaaggacc gttcaaccat ctatttccgc ttaggaaaag cggacgaaag caattttcga 582421 atcgccgctt ttgatctgaa gacgaaaaag tataaaaatc tttatcctgc cgctaatgat 582481 caggatgaca ccgtcagcag cttcttttat aaccaaaaaa acgattcatt tgcattgctt 582541 cattattctg tagaagaaga ctacaagaaa acagatgaag caaacgaaaa gggcatcgac 582601 cctgaaccga caacgattca ttttgcggaa ggccgccaaa ataaatttaa tgagctgaaa 582661 agcctgaacc aatttatcag cgatattgct gtttctgatg atgataaacg tattttattc 582721 acatcatata cgcaaaaagg aacggagcaa accgcttcta ttcaaatgct caatgcggat 582781 acgaaaaaat atgaaagcat catctcaaat caaaaatcat ttaagctgtt aattgacgca 582841 cagcctcagt tttctaagga tgggaagaac atttattttc ttgccgaagc caagggggct 582901 aaaaagctga aggacgaaac agggcgtgaa gctaaggtgc ggacgattta ttcctatagc 582961 cttgagaata agaccttcaa aaaagtatgg gaaaatccga acggcatcat caacagcttt 583021 tttgtgatta actaataaaa accactcggc atgagctgag tggctttttt aatggatgag 583081 gtgcagggct aatgatccga gccatttaaa gatatgaatc agaggtaccg acaaaaacag 583141 aagttcaaca tatgagttca ttgcaacatt cagctttttg aacgcagctc tttttttcaa 583201 gtctttttgc tgctggtttg agatcacgtt atcactcctc ttatatccat attataccat 583261 taaaacagac aaaaaagccc taaacgttta cagttttggg cttctttctt cgtatttggc 583321 ctcttgcaat gagaggcttt tattctgaaa tatagaattt tgtctccgtt cggggtttgt 583381 ttgcttgcgg gagactgcat ttgttatagg gaagaactag cttgttttcg tttggctgtt 583441 gttttggaga ttcactaatg aacggatgcc gtcgaccatt ttacttccgc acaaagggca 583501 caatggcgta tcactgctgg cgaagttttt tcgggtccag ccattacagt cttcttttgt 583561 gcattcccaa gtactcacat cttcctttgg cagcggttct tgatttcgtt tgttatagta 583621 agacataaag tcacttcttc cctcatgtat tttactgcac atttcctatt gtctcatact 583681 tttccctaat ctcctaattc ctttttcttt atgactttcc aataacccca tctaaaaagg 583741 agaggagtgt gctgttaaaa gcatctggct cttctaaaaa cgggcaatgg ctgcttttag 583801 gaaaggtaac gagtgtcgcg tttggaatat tgctgcgcaa gtgttcccca gctgctgtag 583861 agaaaaattt cttgtcttcc ccgaagcaca gcaatgccgg cacattgatg ttttggaggg 583921 tgccccggta atcagcggcc gtttggttaa ataaaatcgt gctagaaatg gcagccggct 583981 gtttgaggat ttctgccagc atccattctg tttcggtctc ggcaggcggt tctgcgaaca 584041 tattctggat gaagctttcg tagaaaggca gcgggtcagt ttgaatggcg tgcatcgctg 584101 tttttaagcc gtcaaaatca aatggaccat gttcccagcc ctcccattga tagtccgaag 584161 cggattgatc gatgatcaca gcggcttgaa tgttatcatt cccaaactga ttgagataat 584221 cccatacgac aaaagcaccc attgaccagc cggcaagaac gacatgatca agctccattg 584281 catttagaaa ttcccttatg tcacgggcat attgggaaat ggtgtggccg tgaagcactt 584341 tgtcagattc gccgtgtcct ctaagatcaa gacgaataca ttgataattg gcagaaagca 584401 ccgaaaattg tttgtggaaa aattgtccgc tcatcagcac cccatgtata aacaggatcg 584461 gcgtcccgct cccgtgtgtt tcatagtaaa ggcgtgtctg atcttctaat atgatgtatg 584521 gcatgtttct cctcctttag tttccatcat gagtatggct ggctgctgtt gagctgatga 584581 tggcagctgt cgcggctgcc tgctgcgctt gaatgactgt ttcgatagcg gtgtatagtc 584641 ctgattccat cagcagattt ttctccatat gctcactgag atagaggctg acagcaattt 584701 taaagttcat ttccttttgc catttaaaag ctttttcctg gtttaattcg tcagtgatgc 584761 acaaaacggt tttgatatct ggctcttcca gaaatgtgag gagagcaagg tctggataat 584821 gataatcctt tgtttttttg acagattcag tgatcgattg atatatctgt ttgcaagcgg 584881 aaacaagcat ttcgggctct ttttcacttt gcaaggccag aatatggctg acctgatgta 584941 agtactgtcc ttttttaaag ccgttggctg ccagcagttg atagcatgtt tccgccttct 585001 gtagcgcctg caaacctttt ccgttttctc caagcagtac ggcaagcgga acattctgag 585061 ttgaagtgag gaaataatga tttttcttca tctgctgata aacagctagc cccatgttca 585121 tctgttcttt ttggtttgtc gtttcagatt tgccggtgag caagatcaga gcggaaaggt 585181 atgtgaacat atcccgctta taccctagct tcaccatttc attgtataca tcgatgaaag 585241 tctgaaatgt ttgttttgcc tcatgctgaa aatgaatgtc cagaatagat gcaacagtaa 585301 agcggtggtg tgaattgagt gttgagaagc tgccgatgtt tgatttgata tagctgctca 585361 aatcataaaa gcgctgaaaa tcaaactctc ttttattcac aatatatgca gaagaaatga 585421 gcattaatat ctgatcgtgt gaaactttcc attttaattt tgtttttaat tcagcataaa 585481 tggaaatgta atgctttgtt ttttcatgta gatcgtgtgt gagcataaaa agcagctcct 585541 tttgttgttt ttacgtaata cgataaatag ggccaaaggt ttcataaaga aaaaacttgc 585601 ctgctagagg caagtttgtc gggttattta tggggatcag ttatatccat cggtctcatc 585661 atgtcatagt cttcatgctc tagaatatgg caatgccata cgtatcgtcc gctgtacgga 585721 ccgaatgtcg ccgcgattct caggacttca cctgcatgcg cttgaatggt gtctttccag 585781 cccttttcac ttggcggcgg cgggacagcc ggaccggtat aggacaattc cccgctttct 585841 tgataacggg cgatatcaaa cggccgccgg tctaatacac ggaaggagac tagatgcagg 585901 tggatcggat gtgttccgcg tgtcgggttg ataatggacc atatttcagt tgtgccgact 585961 tttggtgttt ctgtgacggg atcgtgccag cgtttgttat taagcagaag gacgggtctg 586021 ccgtattcgt cctgggtgcc tgccagtttt aacgttctga tgttttgtat tctttcatgc 586081 tgtaccgaag ggtatgaggc gaggtacttc ggctttctgc tttcgtcttt ttgtgccaat 586141 ggttttgtga ctctgaattg catgatattc gcatctgttt caggattgac gtcaccgccg 586201 cagcccgcgc tgtttgccaa aatgatcgat tctccttcat atgctgtgaa gtcaatgatg 586261 atatcgtaac gttcagcagg cgcaaggctg aaagaattca gtttaacaga tcgcggcagg 586321 agccctccat ctgaaccaat ctgaataaaa tctccgccat tatcgagtga caggttatag 586381 gttcttgtat tggaggcgtt gatgacacgg aatcggtatt tccttggctc gacttccaag 586441 tatggccata ccttcccgtt gacgagtatg gtttctccgc aaaaagccgg aacgattgaa 586501 ggattaggca gtgacggaga agggttttcc ggtgcgctcg gataaaacaa agaaccatcc 586561 tcattgatcg tgcggtctgt gataagaagc ggcacatcgt attcgtctga aggcagtttt 586621 aagcgttttt cctttgggtc atgaatgata tatgcaccga caagtccggc atagacattt 586681 agcctggtga gcgccatggc gtgatcgtga taccacaata tagccccgcg ctgctggttt 586741 ggataatgat aaacctctct tttgaaataa ggtcctgttt gttcaaagtc tttggaaaac 586801 caagcctccg gatacccgtc actatcatct ggcgtgacgc cgccgtgtaa atgaacaaca 586861 gtctttacct cgggctcttc atgctggctg tcactgtgat gaatggtgtg atcaatcgga 586921 aggaaatgcg tggaaggaag gttattcatc cattttacat atacgttttc atttctttta 586981 acctcaatgg tcggtcccgg aaataagccg ttgtagcccc acaggcgggt tggagggaga 587041 tcgcgatgga gctgatgagt gcattcctcc atggtgactt cgtagtatgt tttttctttt 587101 gattgctgta ctggctttag tgtatctggg attgggagag catccacaaa tttttcaagt 587161 gtcattttca tctgtcctta tctaaatttt ccaaattggt actatagtta atgacaataa 587221 ggacgtgatg gttacaaaaa atcttcgtgc tgcagcccgc ccgaagaaga aaataacaaa 587281 atcctaaacg gcaggccgtt taggatttga tcagcattaa ggcaggatat cgggttgctg 587341 ctgtgtgact gggttggcag ccgctttctc gctcaccttg cgttttctga acacaaggta 587401 agaaatcaga acgattcccg tgatgacgcc tgtcagcagc agctcgtctc tcatggaatc 587461 aataaacgcc atggacacta aaattccgca aatggcgatg atggtcaagt aggttaggaa 587521 agggaagagc cacattttga tcttcaatgc ttctgggttt gttttttcga gttttttccg 587581 cattttcagc tgggaaacgg cgatgacaag atagacgagt aaagcgattg cgcctgatga 587641 gttgactaag aataaaaaga cggtatccgg tgaaaaatag ttcattacga ccgcgatata 587701 agagaaaaat gtcccggcca caatggcttg tacgggaacg ccttttttgc tcaatttcat 587761 aaaacggcgc ggcgcttcat ttctttctgc aagtgaatac agcattctgg atgtggtata 587821 caaacctgaa ttcaggcaag agagtacggc tgtgaggacg ataaagttca taatctgtgc 587881 ggctgcgggc actcctatat gctcaagtac agcgacgaaa gggctttcta aaatatttgc 587941 tgaattccat ggcaacagcg ccacgacaat ggcgattgag cccacgtaaa agacgatgat 588001 gcgccataca acggatctgg tggcttttgt cacagattcg atcgggttgg atgtttcccc 588061 tgctgcaatg gcaacgattt cagttcccat aaaagagaag atgacaacga caatgccgag 588121 caatacggag ctgatgccct ccgggaaaaa tccgcctttg cctgtaagat tcgaaaaacc 588181 gactggctca ctgcccggtg caaagccaaa aataaaggca aaaccaacga ttagaaaagc 588241 aatgatagtc acaactttaa tgagggagaa ccaatattca aactcaccga aagacttaac 588301 ggagtagacg tttgtcaggg tgagcacaat ggtcaagatc aaacttgtca gccacagcgg 588361 aatatcatgg aaccagtatt gaataatgcc agcaccggca atggcttcga tcgctatgac 588421 gatcacccag aaaaaccagt acagccagcc gattgtaaat cctgcccacg gtccgatggc 588481 gtcgtgagcg tattgagaaa acgatccgct cgtcgggttt acggcagaca tctcaccgag 588541 cattctcata ataaaaatca ccaataatcc ggctaacgcg taagaaacaa cggcacccgg 588601 accggtcgag tgaatcactg aaccgctgcc tacaaatagg ccggctccga ttacaccggc 588661 aatcgaaatc attgtcatat ggcgggtctt taattccttt tttaatcctg attgagactg 588721 gttcataagt tacctccttt taaaatgcaa tcattactga atattatgat aattgaaact 588781 ctatcataaa tatacagttt gtcgaaaatt cgtgtaagaa aatataccag cttatttcaa 588841 atttgtagtg ttttgtttgc gctttcagcg aatgtgtgga aaaaatgttt cgttttttat 588901 tcgctgtgtg attttgcgta atatttacaa ttcgatagaa tgcgagaagc actggtgtcc 588961 ttgggtttga tgggattttt ggcggagcaa ataaattgga tgagagaaaa agtgttcctt 589021 cgtcactatt tttctgtggc gggtgaatca tgtttctgta gacccactgc ggatcagctt 589081 tgtaagataa taataggaaa atgtgagcga gaggaggttt tgtatggaga gatatgatga 589141 actgaaaaag ggagaatccg gagcgctggt cagcattgcc gcgtatctag ttctttccgc 589201 aattaaactg atcatcggtt atctttttca ctcggaagca cttacggcag acgggttaaa 589261 taacacaact gacattattg cttctgttgc tgtgctgatt ggcctgcgca tctctcaaaa 589321 gcctcctgac gaagatcatc catacggcca ctttcgagcg gaaacgattg catcgcttat 589381 cgcatcgttt attatgatgg ttgtcggact gcaagtgctg ttcagcgccg gagaatctat 589441 tttttctgct aaacaagaga cgccagatat gattgcggct tggacggcag cgggcggggc 589501 agtcctgatg ctgatcgttt accggtacaa taaaaggctg gccaaaaagg tgaagagcca 589561 ggcgctcctt gctgcggctg ctgataataa atcagacgca ttcgtcagta tcggcacatt 589621 tatcggcatt gtggctgctc aattccatct tgcttggatt gatacggtca ctgcgtttgt 589681 gatcggtctg cttatttgca agaccgcatg ggatatcttt aaagagtcat ctcactcttt 589741 gacagatgga ttcgacataa aggacatttc cgcttataaa cagacaatcg aaaaaatctc 589801 cggtgtgagc cgtttaaaag acataaaagc aagatacttg ggcagtacgg ttcatgttga 589861 tgtggtggtt gaggtatcgg cagatttaaa tattacggaa agccacgata tagccaatga 589921 aattgagcgg agaatgaagg aggagcatgc gattgattat tcgcatgttc atatggagcc 589981 tttagaacaa aaataatgga gcttcctgtc acaggaagct tcagcgtgtc gacaaaccct 590041 cgcattcgtt gtcaggtctg cgcttcggtg ctcacgaatt agaacattcg ctccgctcct 590101 atgctcgtcc ttcctagact tcaagggttt tcaatcacgc tgaaaagatg acaaaaccct 590161 aaaatgaaag ccattttagg attttgtcaa caatctggag cttcctgcca caggaagctt 590221 ttttgtgtgt tttggccagc tttattggta acaatttgct agaatcgttt ttttatacag 590281 attgcttttt gtggtaaagt taggttacat tatgatgaat tttgtagatg actaggagga 590341 aaataatggc atatcaagaa gacctgcatc ctttgctggg gaaagcagtt gaacatatta 590401 atagagtaat ggttggaaaa cgagacatcg ccatactcag cttagcagcc cttcttgcca 590461 aagggcatgt gctgcttgag gatgtacccg gagtcggaaa aacgatgatg gtccgcgcgc 590521 tggcaaagtc aatcggcgcc gatttcaaaa gaatccaatt cactccggat ttgctgccat 590581 ctgatgtaac aggggtatct atctataatg cgaaaacgat ggaatttgaa tatcgtcccg 590641 gcccaattat gggaaatatc gtgctggcag atgaaatcaa ccgtacctct ccgaagacac 590701 agtcggcttt gctcgaagcg atggaagagg ggagcgtcac ggtagatggc catacgatgc 590761 agcttgccga tccgtttttt gtgatggcaa cgcaaaaccc ggtcgaatat gaagggacct 590821 atcctttgcc ggaagctcag cttgaccgtt ttttattcaa acttcggatg ggttatccgt 590881 cctttaatga agagcttgac gtcttatctc ttcaggaaaa aagccatccg attgagacgc 590941 ttgagccggt tattgcaaaa gaagacttca tctttttaca gagggaagtg caaaatgtcc 591001 gtgctgatga cagcattaag gaatatatcg ttgaaattgt gcagaaaacg agacagcatc 591061 cttctgttca attaggcgtc agtccgcgcg gctcaatcgc cctcatgaaa gcggcacagg 591121 catacgcgct gctgcatcat cgcgactatg tcataccgga tgatattcaa tatttagctc 591181 ctttcacgct gccgcaccgg atgatgcttc atcctgaggc aaaatttgaa gggattcagg 591241 cagaagcgat cgtaagggag atcatgtcag ctgtgaaggt gccggttcaa aggtcggcgg 591301 tccgctgatg aataagaaat ggcaatggct cgtatatggt tggaagctga ttatattaac 591361 tttattgacg gctgctgttt tttcttatgc gatgtttcag ggcggctttg tcagctggtt 591421 tttgttttac gcgtttctcc cttttgtctt gtatgccggg ctgttggcct tgtatccgct 591481 ccgttctttt caggcttcaa ggcaaatgga taaaacacaa ttgcatgcgg gggacaggct 591541 gggcgtaacg gttacgctga gaagaaagct gccatttccg ctgatgtata tggtgattga 591601 agattgcctg ccagaaggta tcgagtcatt aaatcgagac ggagccgcgg ccaaacggct 591661 cgtttttcct tggtttaaac ggagcatgac gatgtcgtat gaattagctc gggtaccgcg 591721 cggagagcat cactttcatt ctgtcagggt gcgaaccggg gatgttcttg gcttgattga 591781 aaaaacagca ttttttgagc tggatgatac cttgtttgtt tatccattct atcagcgttt 591841 ttcctatcag gtgaatgaga ggcatcagga agacggtgta agcggttctt ctcctattca 591901 tcagcaccat tcctcagtcg cagcaagtgt gcggaattat cagccgggag accggtttgc 591961 tgcgttagat tggaagacat ctgcacggcg gagccagctg atgacgaagg aatttgagcc 592021 ttctcgcagc aaaaatctgt ttctgctgat ggaccgtttt tcctcagacg cattcgaaga 592081 ggtcgtttca gtgacagctt cgattcttca ttctgtttta aaaaacggcg cgggtgctgg 592141 tctggcttcc atcgggaagg aaaaaaacat tttccctatt caggaagggg atcagcattt 592201 taagcacatg cttcggcatt tagccatcgc tcattgtgat gcggcagacc cgataagccg 592261 atatgcacgg gaagagctgg gaaagccatc tgttcgccaa gctgatcaag ttgttgtcac 592321 gggacagtta acggaagata tgctgcacct cgcagaaata ggaggcggcc gggttacggt 592381 gatactggca aaagagaaag atgctgagct ctctcaagct gaaaatgtca tgattgaacg 592441 catgatgaaa cgccaaatca gagttcggat catgaggggc gggcgagttt cgcgtgttgt 592501 ttagaaagag aggtgactgg ttcacatgcc gcacgatgat cacaagggaa gccgtttgag 592561 cttgctgtta ttttattttc tggctttttt attgctgtgg gagtggctta ggccgcttga 592621 cagttttact gaaacgaaac atacaggctt ttttagtgtc tttatcggct tgacgtttct 592681 gctgactttt ttcaggatga ggtggtttgt caccgttcct ttttgtgtca tatttacatt 592741 gatctcgata cacatcctgt tttatcaagg atctatattc gacttgagct gggtcagctc 592801 ttttttgcag gatgtctatc tgaatatcac gctgattcaa tcagggcaat ggaatgacat 592861 gattccttca tttcggaccc tgctgttttt tgtgctgctg tggctgctgg tctatctcct 592921 gcattattgg gtgatttacc agagaagaat tttgtttttc tttttgatga cagtagcgta 592981 tattacgatt cttgatacct ttacgccata tgatgccact tttgccgtaa tccgtatcgt 593041 gctgatcggc ttctttatgc tgggcctttt atacttggaa cgcattaagc tgatggaaag 593101 aatcacactg ccaaaaacat ctgtcctgaa atggtttctt cctttatctg tattggtttt 593161 ggctgcaacg ggattcggac tcgccgctcc aaaatcagag ccggcttggc ctgatccggt 593221 gccttttctt aaaaaaatca ctcatcaaga ccgcgtgtct gcaggggaaa gcaaaatcgg 593281 atacgggaat catgatgaat cactcggcgg cccgttccag caggatgcta cacctgtttt 593341 tacatggcag ggaaaagagc gtacgtattt ccgtgtggaa acgaaggaca cgtataccgg 593401 aaaaggctgg attgaaacag acacaggcat gtcgtatcag cttagcaatg gaaaagttga 593461 aaatctgtgg tttgaccata aggttgcgac agagcgccgc accgtccgtg taaaagtcga 593521 taagcactac gggtataacc atctgatgta tccgattggt gcggaaacca ttcagccaaa 593581 gcaggctgtc tcacttgaaa tgaacggcaa cacggagcaa atttctccga tcagtgaaca 593641 agccggtgaa atcagaaata tggggaatta tacagtaacg tacaattccc cggtctataa 593701 gctggatgaa ctgagaaagg taaaagtgag aaaaaacagt gaggagtaca cattcagcga 593761 tcgctacatg cagcttccag attcactgcc agagcgggtg agaacccttg cgatcaaact 593821 gactcaggat cacgacaata tgtttgataa ggtgaaagcg gttgaggact atttagggtc 593881 aaatgcgttc acatatgaaa cagaaaacgt gaccattccg aagaatgatg aagattatgt 593941 cgatcaattt ctctttgaaa cgaaaatggg ttattgtgat aacttttctt ccgccatggt 594001 ggtgctcttg cgctcggccg gcattccggc ccgctgggta aagggttata cgtccggcga 594061 atacaaagaa gcagggaaca aaaatggcag catttacgaa gtgacaaata acaatgccca 594121 ttcctgggta gaggtgtatt tcccggaaca gggctgggtt acatttgagc cgactaaagg 594181 gtttacaaat ccggctcaat ttacatcttc tgacacaaaa gactctggca gcgatagcag 594241 cagctcgccg aagaaagcaa aagagaaaca gaaagaagag aaaaaacagc cgcaaaaaga 594301 ggaaaaacaa aaggaaaagc gggagccagc tgtttctaaa aagccgtccg cttcgcatac 594361 taatgccggt gcgggcttgt atgcagcgct tgcggttctt gcagtcctcc tggtggcagc 594421 tgtattgctg tatgttttcc gctcgttatg gattcctgtt ttcgccgtga ggaaattgaa 594481 gcggcgcagt gatcagcacg cgttttttga ggcatatggc gcgctgctga aacaactgaa 594541 gagaaaagga ctgccgaaac gagacagtga aacgctgcgt gattatgcaa aacgaattga 594601 tgaaaaatac gacatagaag acatgtcaaa gctgacatta agctatgaaa gggcgcttta 594661 cagaaatgaa gattcttcgg cgctatggaa tgattcgaga gagttatggg aaaatttaat 594721 taaaagaaga tggtcttgac cgcttatcga cgtgttgtta gaattagtga atattatcgg 594781 agtctgggag cgagttggcc tgactccggc aaacggcctt gccaaagagg gcggagcgag 594841 cttcatatct gtcctcgttt ttttctgtgt caaaaaactt agaggagatt aggtgacaac 594901 catgacaaag ttagtgaatg aaatgattct tgtccttgat ttcggcagtc agtataacca 594961 gctgattaca cgccgtatcc gtgaattcgg tgtttacagc gagctgcatc cacatacatt 595021 gacggctgaa gaaattaaaa aaatgaatcc aaaaggaatt attttatccg gcggtccaaa 595081 cagtgtgtat gatgaaaact ctttccgctg tgacgagaaa atcttcgagc ttgatattcc 595141 tgttttggga atttgctacg gcatgcagct gatgactcat taccttggcg gtaaagttga 595201 agcggcaagc cagcgtgaat acggaaaagc aaacatccgc atcgaaggca cacctgattt 595261 gttcagagat cttccgaatg aacaagtggt ttggatgagc cacggcgatt tggttgtaga 595321 agttcctgaa ggcttcactg ttgacgcgac aagccatcac tgcccgaact cagcaatgag 595381 caaagcggac aaaaaatggt atggcgttca gttccacccg gaagtgcgcc actctgaata 595441 cggcaatgat cttctgaaaa actttgtatt cggtgtttgc gaatgcgaag gcgaatggtc 595501 aatggagaac tttatcgaaa tcgaaatgca aaaaatccgt gaaacggtcg gagacaaaca 595561 ggttctttgc gcgctaagcg gcggcgttga ttcctctgtt gttgctgttt tgattcataa 595621 agcgatcggc gaccagctga cttgtatctt tgtagaccat ggtcttctcc gtaaaggcga 595681 agctgagggt gttatgaaaa cattcagcga aggctttaac atgaatgtga ttaaagtaga 595741 cgcaaaagat cgattcttaa acaaactaaa aggcgtttct gatcctgagc aaaaacgcaa 595801 aatcatcggt aatgaattca tttacgtgtt tgatgatgaa gcggacaagc tcaaaggcat 595861 cgactacctt gcacaaggta cgctttacac agatatcatc gagagcggta cagcaacggc 595921 gcaaacgatc aaatctcacc acaatgtcgg cggacttcct gaagacatgc agtttgagct 595981 gatcgagccg ttaaatacgc tcttcaaaga cgaagtgcgc gcgcttggca cagagctcgg 596041 cattccggat gaaatcgtat ggcgtcagcc gttcccagga ccgggactcg gaatccgcgt 596101 tcttggcgaa gtaacagaag aaaaacttga aatcgttcgt gaatcagatg caatcttgcg 596161 tgaagaaatt gcaaatcacg gcttagagcg tgatatctgg caatacttca ctgttcttcc 596221 tgacatccgc agcgttggtg ttatgggtga cgcaagaaca tatgattaca caatcggaat 596281 ccgcgccgtt acatcaatcg acggcatgac atctgactgg gcgcgtatcc cgtgggatgt 596341 gcttgaagtc atttcgacac gtatcgtaaa cgaagtgaag cacattaacc gcgtggtgta 596401 tgatattaca agtaagccgc ctgcgacgat tgagtgggaa taagaatcaa ttaatggaaa 596461 ccatcttttt ggcaattttg ccgggaagat ggttttattt gtttattacg aacaaaatcc 596521 gattttgcgc gactattgtt cgctttttgt attgtttttt caaaatgaac ttggtacaat 596581 agacacagaa atcaaataag atgaattcgt ataatcgcgg gaatatggct cgcaagtctc 596641 taccaagcta ccgtaaatgg cttgactacg taaacatttc tttcgtttga tataaataaa 596701 acacggttat ttattcaaac tgaaatccgt ctgtagtcaa gcgtcccaaa atgtattggg 596761 acgtttttta tttggcgttt tcaggacaga ataaatagca aagagtgaag ggagtcaaat 596821 agcttgaaaa cgttttttca gtttgatgag ctgggcacca gctatcgcaa tgaaatcatt 596881 ggcggattaa cgactttttt atctatggca tatattttgt tcgtcaatcc gattacgctt 596941 gctttggaga gcgtgaaaga ttttccggag gcgctgagaa ttgaccaggg tgcggtcttt 597001 acggcgacag cgctggcgtc tgcagcaggc tgtatcttaa tgggattaat agcgagatat 597061 ccgattgcca tcgcgccggg tatggggctg aacgcgtttt ttgcgttttc tgttgtcctt 597121 ggtatgggta tttcatggca ggcagctttg tccggtgttt ttatttcagg tcttattttc 597181 gttgctcttt ctttaacagg ttttcgtgaa aaaatcatca acgccattcc gcctgagctg 597241 aaattggcag tcggtgcggg gatcggcctg tttattacat ttgttggatt acaaggttca 597301 ggaatcatta cagcgaatcc ttctacgctc gtcacgatcg gaaacattca cagcggtcct 597361 gtgctgttaa cgattttcgg tgtgattgtc acggttattt taatggtgct tcgcgtgaac 597421 gcaggcgtgt ttatcgggat gctattaaca gcggtagccg gcatgatttt cggtttggtt 597481 ccggttccga ctcaaattat cggcagtgtg ccaagccttg cgccgacttt cggacaagcg 597541 tggattcacc tcccggatat tttctctgta caaatgctga tcgttatttt aacattcttg 597601 tttgtcggat tttttgatac agctggtaca cttgttgctg tggcaacaca agctggttta 597661 atgaaggaaa acaaattgcc gcgtgcgggc cgtgcgcttt tagctgattc atcttctatt 597721 gtgatcggtg ccgtgcttgg tacgtctaca acaacttctt acgtggaatc aagctcaggt 597781 gtcgctgcgg gtgcccggtc aggatttgcc gcaattgtaa cagggattct ctttttactg 597841 gctacgtttt tctcgccgct cctatcagtc gttacgtcaa atgtaacagc gccggcgctt 597901 attattgttg gtgcattgat ggtggcgccg cttggcaaaa tcgcttggga taagttcgaa 597961 gtggccgttc ctgctttcct taccatgatc atgatgccgt taacgtacag catcgcgact 598021 ggtattgcca tcggatttat tttctatccg attacaatgg tgtgcaaagg aaaagcaaaa 598081 gaggttcatc caatcatgta cgggctgttt gtcgtattta tcctgtactt tatcttctta 598141 aaataaggaa tgaaaaacca gctgcactgg cagctggttt ttttgttgca aaagataaaa 598201 ccatttcata cgatataccg tcatgtagat gtgccgccat gctttactta aatggaaatg 598261 acttgactgt tcaggaaggc ttcggtacct tatataagtg ttttattttc ttgctgaatg 598321 gtattccgcc gtattttttt gataggagtt gctgacatga cggaagaaag aaaagaaacg 598381 tttgaagaag aaattaacca gagtgaaaga atagatgcag atgaagaacc gctatcgaga 598441 atgtccagaa aggcgagccg gcaaagcaag cagaagcaaa aacaaaagca gaaaccgcgc 598501 caggaacgcg gtgaatcaac tgttaaagac aagcttgcgt ctgtttgggc agccatcaac 598561 agatattgcg gttttgcgtt ctcgatttta aaatctccgg cgaaaactgt cgtaacggat 598621 ggtttttctc attataagta cggtctgatt tcaatgctta tattcagtat cattttttca 598681 attgggaatt ggtttcagtt aaaggcaagc tggaatcggc cgctcggttt cggagaacgc 598741 catcatgctt tctatgacgg gtttttagtt gttcttgtgt atttgctgat ctttttcgcg 598801 gtaatggtct ttgctatatg ggctgtctcc cgctatatga tgaagcagaa ggtgacgttc 598861 agagaagcgg ctgccgtatt gggttcattg cttgtacccg taattgctgt ttcaatcctt 598921 tggctgatct ttgcgatcgt aaatatccca atgctgacag tactgtttac ggtgctgatc 598981 ttgttttcca tcttttttat catcgcgctg tatgtacagc gtgtgtacca ggcggcacaa 599041 gatgcaccaa ttgattatat ctattgtgta tttgcagtag ttgcgatagc gctgctgttt 599101 acggcagtga cttggccgtt tatttctgaa tatattacgg cgtcgttgat tccgctttaa 599161 tgaaaaaacc ggctaatcct agccggtttt tttatgtcac actttttaca aatatatcta 599221 aaaaacatag ttgatttgta ggattaaccc gtgtatgatg gggaaaatgc tgaaaacgtc 599281 cagcgcaaaa acctttatgt ttaaggagga tgatggacat ggctgatgta cttcgccgag 599341 caattaacca aaagaagcaa tttttaaaaa ccaaattact gctctcggaa ttttatcaag 599401 gaagagggga acagcttgct gactacacgc tgagtgagct tgagaaagaa tacaagtccc 599461 ttcagaaaat gaaaaaagag atctgacaat agatataaag aggtgagtct gctgaaaagc 599521 gggctttttt gttttgattt tgaaaaggcg agaaagaggg taaactacta ctgttcaaca 599581 cataaaagcg tgtcgaaata ttttgcttaa gcttacgggc gaagctgatt gtaaacggct 599641 catttctcta gtagaatatg aatgctttgt gcaagctgaa gagtaggggg atgaataaaa 599701 tgatgcaaac catcttatca aatgggatag ccatggttct cataattctc attattaata 599761 ttgtctatgt gtcatttttt acgataagaa tgattttaac gctgaaagga cagcgttatt 599821 tagcggccgg catcagtacg attgaaatac tggtttatgt gacaggactg agtctggtgc 599881 tcgataactt agaccagatt caaaatgtga tcgcgtacgc gctcggttac ggtcttggcg 599941 taattgtcgg catgaaaata gaagaaaaat tggcgcttgg ctatattatg gtcaatgtga 600001 ttacgaagga gctcgatctt gatcttccga agcagctccg tgaaaaaggc tacggcgtga 600061 caaactgggt ggcaggcggg cttgaaggcg accgcacagc ccttcagatc ctgacgccga 600121 gaagatatga actccagcta tatgatacga ttaaaacact tgattcaaaa gcctttatta 600181 ttgcgtacga accaaaaaca atccacggcg gcttctgggt caaagcggtg aagaagagga 600241 gaattaaaga ataatggcaa agccgaagaa gaaaaagttt gaagtgacag agcagcaaac 600301 gattgatgcg gtgcttcagc aaatgaaaga agaaggatat ctgcctgtaa ggcgaatgga 600361 agagcctatt tttatggaaa aaaaggaaaa tgggtcaatt cagatcgttc cgtgcgggaa 600421 aaaaatcgta tttgaaggga aattgatcta aaacacgaac attagtagaa tgaatttttg 600481 tatcgttcga taatatcgtt gacattatcc atgtccgttg ttaagataaa catgaaatca 600541 aaacacgacc tcatataatc ttgggaatat ggcccataag tttctacccg gcaaccgtaa 600601 attgccggac tatgcaggaa agtgatcgat aaaactgaca tggatatatc gcagaagcga 600661 acgactgacg atacatgtac catgcccggt ttgtattgct tcctcataag tgcaatgcag 600721 agcgggtatt ttttattttc tgaaaacaaa agcattagaa ggtggggaac agaatgcagc 600781 cgctagtagg aatcatcatg ggaagcactt ccgattggga gacaatgaaa cacgcatgcg 600841 acatacttga cgaactcaat gttccgtacg aaaaaaaggt cgtttccgct caccggacgc 600901 ctgatttcat gtttgaatat gctgaaactg ctagagaaag aggcatcaag gtgattattg 600961 ccggtgccgg aggagcggcg catctgccag ggatgacggc tgcgaaaaca acactgccag 601021 tcattggagt tccggttcag tccaaggcgc tgaacggaat ggattcactt ctttccatcg 601081 tccaaatgcc tggaggcgtg cctgttgcga caacatccat cggcaaagcg ggtgctgtga 601141 acgcaggcct gttagcggcg caaattttgt cagcatttga cgaagacctt gcccgtaagc 601201 tggatgagag aagagaaaat acaaaacaga cagtgttaga aagcagtgat cagcttgtct 601261 aaacaaatca tctatccggg agctgtaatc ggcattatcg gcggcggcca gcttgggaaa 601321 atgatggctg tgtccgccaa acaaatgggg tataaagtcg cggtcgttga tccggtgaaa 601381 gattcgccgt gcgggcaggt tgcggatgtc gaaattaccg ctcattataa tgaccgtgaa 601441 gcgattcgaa aattggctga aatcagcgat atcatcacat atgagtttga aaacatcgac 601501 tatgatgcgc tgcattggct aaaagatcat gcgtatctcc cgcaaggaag tgagctgctg 601561 cttattaccc aaaaccgtga aacagagaaa aaagcaattc aatccgcggg ctgtgaagtc 601621 gcaccgtaca gcatcgtcaa aacaaagaat gaattgaaac aggcagtaca ggagctcagg 601681 cttccggcag tgctgaaaac atgccgcggc gggtacgacg gcaaaggcca atttgtgata 601741 aaagaagagg cgcaaatgga gcaggcagcc gctctgttag aacacggaac ttgcattctt 601801 gaaagctggg tttcttttaa aatggaactg tcggtgatcg tcgttagatc ggtaaacggt 601861 gaaatttcaa catttccgac agctgaaaac attcaccaca acaatattct tttccaaagc 601921 atcgtgcccg cacgggtaga gaaagggatt cagcagaagg ctgctgatct cgcagttaag 601981 cttgcagatg agcttaacct tgtcggaccg cttgctgttg agatgttcct gacagaggac 602041 ggagagcttt tggtcaatga actggcgcca agaccgcaca attcagggca ttatacgctg 602101 gacctttgcg agacgagcca gtttgagcag catatcagag cggtatgcgg gcttccgctt 602161 gggaagacag atttgctgaa gccgggcatg atggtgaatc ttctcggcga tgaagtgaag 602221 cttgttgagg aagacccgga gcttttaaaa gaggcaaagc tatatatata cggaaaacat 602281 gaaatcaaaa aaggccgcaa aatggggcat attacattta tgaagcagcc tgaagacgaa 602341 tggattcagg agatcacaaa taaatggatg aatagagacg gaggacaagc agaatgatcg 602401 aacgttattc aagacctgaa atgtccgcga tttggacgga tgaaaacaga tttcaagcat 602461 ggttagaggt tgaaattctt gcctgtgaag cgtgggcgga gcttggcgtc attccgaaag 602521 aagatgtaaa ggttatgcgc gaaaacgcgt catttgacat caaccgcatt ttagaaatcg 602581 aaaaggacac gcgccatgac gttgtcgctt ttacgcgcgc tgtatccgaa tcactgggcg 602641 aagaaagaaa atgggtgcat tacggcttaa cgtcaactga cgttgttgat acggctcttt 602701 cctacttatt aaaacaggca aacgatattt tgctcaagga tcttgagaga tttgttgaca 602761 ttataaaaga aaaagcgaaa gaacataaat acacagtcat gatggggcgc acacacggcg 602821 tacacgctga gcctacaaca ttcggcttaa aacttgcgct ttggcatgaa gaaatgaaac 602881 gtaatcttga gcgcttcaaa caagcgaaag caggcatcga ggttggaaag atttccggtg 602941 ctgtcggcac atatgcgaac attgatccat ttgttgaaca atatgtctgt gagaagctcg 603001 gattgaaagc agcaccgatt tccactcaaa cccttcagcg tgaccgccat gctgactata 603061 tggcaacact tgctttgatc gcgacaagca tcgagaaatt cgctgtggaa atccgcggac 603121 tgcaaaagag tgaaacacgt gaagtagagg aatttttcgc gaaagggcaa aagggttcat 603181 ctgcaatgcc gcataaacga aatccgattg gctctgaaaa catgacaggc atggcgcgcg 603241 tgatccgcgg ctacatgatg acagcttacg aaaatgttcc attatggcat gagcgcgata 603301 tttctcattc ttcagcagaa cgaattattc ttccggatgc gacaattgcg ctgaactaca 603361 tgctgaaccg cttctccaac atcgtgaaga acttaacggt cttcccggaa aacatgaagc 603421 gcaacatgga ccgcactctc ggccttatct attctcagcg tgtgctcctt gctttgattg 603481 acacaggcct gactcgtgaa gaagcctatg atacagttca gccgaaagca atggaagcgt 603541 gggaaaaaca agtgccgttc cgcgagcttg tggaagcgga agagaaaatc acgtcacgtc 603601 tttctccaga aaaaattgct gactgctttg attacaatta ccatctgaaa aatgttgatc 603661 tgatctttga acgtttaggt ttagcataga agaagctttt agcggcttct tctaagccgc 603721 cgcagtttga aaattcccaa cattcgggtt aggaggcctt ccgtgaatat tgtgaagaat 603781 gaacttttat acgaaggaaa agcaaaaaag atctacaaaa ccgatgacga aaacacgctg 603841 tatgtcgtgt ataaagactc cgccactgcc tttaacggcg agaaaaaagc agaaatcagc 603901 ggaaaagggc gcttaaataa tgaaatttca agcctcattt tcaaacacct tcatgctaag 603961 ggcattaaca atcattttat cgagcgcatt tcggaaacgg agcagctcat taaaaaggta 604021 acgattgtgc cgcttgaagt cgtggtaaga aatgttgtgg caggaagcat gtccaaacgt 604081 ctcggcattc cagaaggcac ggagcttgag cagccgatta tcgagtttta ctacaaggat 604141 gacgcgctgg gtgatccgct catcacagaa gatcatattt ggcttttgaa ggcggcgact 604201 cctgagcagg tagaaaccat taagtccatt acaacaatag taaatgaaga gcttcaaagc 604261 atcttcgacg attgtcatgt cagattaata gatttcaagc ttgaattcgg tttagatgca 604321 gaagggcaag tgcttttggc ggatgaaata tctcctgaca catgccgctt gtgggataaa 604381 gaaacgaacg aaaagctgga caaagattta ttcagacgca atctgggaag cttaaccgac 604441 gcatacgaag agattttcaa tagactggga ggcattcatc atgtataaag taaaagttta 604501 tgtcagctta aaagaaagtg tactagatcc acaagggagc gctgtccagc atgccttgca 604561 cagtatgact tacaacgaag ttcaagatgt gcgcatcggg aaatacatgg agcttaccat 604621 tgaaaaatct gaccgtgatc ttgacgtgct agtgaaagaa atgtgcgaaa aacttcttgc 604681 gaacacagtg attgaagatt atagatatga ggttgaggag gtagtcgcac agtgaaattt 604741 gcggtgattg tgttacccgg ctccaactgt gatatcgata tgtatcatgc tgtaaaggat 604801 gagctcggcc atgaagtgga atacgtctgg catgaggaaa caagccttga cggcttcgac 604861 ggcgtgttaa ttccgggagg attttcttac ggcgattact taagatgcgg cgccatcgcc 604921 cgatttgcga atattatgcc agctgtcaaa caagcagcgg ctgaaggaaa acctgttctt 604981 ggcgtctgta acggattcca gattttacag gagcttgggc tgctgccagg cgcaatgaga 605041 cgcaacaaag atctgaagtt catttgccgt ccggttgaat tgattgttca gaacgacgaa 605101 accttattca cagcttccta cgaaaaggga gaatcgatta caatcccggt tgcccatggt 605161 gaagggaatt tctactgtga tgacgagacg cttgctacat taaaggaaaa caatcaaatt 605221 gctttcacat acggctctaa tattaatgga agtgtcagcg acattgccgg tgtcgtgaat 605281 gagaaaggca atgtattagg catgatgcct caccctgagc gcgcggtcga tgaactgctt 605341 ggaagcgccg acggtcttaa attgttccag tctatcgtga aaaattggag ggaaactcat 605401 gtcactactg cttgaaccaa gtaaagaaca aataaaagaa gagaaactgt atcagcaaat 605461 gggtgtcagt gatgatgagt ttgcattgat agaatccatt cttggaagat tgccgaacta 605521 cacagaaatc ggaatttttt ctgtcatgtg gtctgagcat tgcagctata aaaactcaaa 605581 gccgattctg cgtaaattcc cgacaagcgg cgagcgtgtg ctgcaggggc cgggggaagg 605641 cgccggaatc gttgatatcg gtgataacca agcggttgtg ttcaaaattg aatcacataa 605701 ccacccatca gctctcgagc cttaccaagg cgctgcgact ggcgtaggcg gaattatccg 605761 tgatgtattc tcaatgggtg cacgcccaat cgctgtattg aactctcttc gatttggtga 605821 actgacttca ccccgcgtga agtacttgtt tgaagaagta gtagcgggta tcgccggata 605881 cggcaactgt atcggcatcc cgacagtcgg cggagaagtg cagtttgaca gcagctatga 605941 aggaaatccg ctcgtcaacg caatgtgcgt cggtttaatc aaccatgaag acatcaaaaa 606001 aggccaggca aagggtgtcg gcaacacagt aatgtacgta ggagcgaaaa cagggcgtga 606061 cggcatccac ggcgctacgt ttgcttctga agaaatgtca gactcgtctg aagaaaagcg 606121 ttctgctgtc caagtcggcg atccgtttat ggagaagctt ttgcttgaag catgtctgga 606181 agtcatccaa tgcgacgcct tagtcggcat tcaggatatg ggagctgccg gtttaacaag 606241 ctcaagtgca gaaatggcaa gtaaagccgg ttctggcatt gaaatgaatc ttgacctgat 606301 tcctcagcgc gaaacaggca tgaccgcgta tgaaatgatg ctttctgaat cacaagaacg 606361 gatgcttttg gttattgagc gcggacgtga gcaggaaatc atcgatattt ttgacaagta 606421 tgatcttgaa gcggtttctg tcggacatgt gacagatgat aaaatgcttc gcctgacaca 606481 taaaggagag gttgtgtgcg agctgcctgt tgatgccttg gcagaagaag caccggttta 606541 ccataagcct tctcaagagc ctgcttacta tcgcgagttt ttggaaacag acgttccggc 606601 tccgcaaatt gaagatgcga atgaaatgct gaaggccctt cttcagcagc cgacgattgc 606661 gagtaaagag tgggtttatg atcagtatga ctacatggtg cgcacgaata cagttgtcgc 606721 tcctgggtct gatgctggtg ttctcagaat ccgcggaacg aaaaaggcgc tggcgatgac 606781 gacagactgt aacgcgcgtt atctctatct tgatcctgaa gtcggaggga aaattgctgt 606841 cgctgaagca gcgcgcaaca tcatttgctc aggcgcagaa ccgcttgcgg tgacagataa 606901 ccttaacttc ggaaaccctg agaagccgga aatcttctgg cagatcgaaa aagcggcaga 606961 cggcataagc gaagcgtgca atgttctcag cactccggtt atcggcggta acgtatcgct 607021 ttataacgaa tcaaacggca cggcgatcta tccgacacca gttatcggca tggtcggcct 607081 aattgaagat acagcgcaca ttacaacaca gcatttcaaa caagcaggag atctcgtata 607141 cgtgatcggc gaaacaaaac cagagtttgc cggaagcgag ctgcaaaaaa tgacagaagg 607201 ccgtatttac ggcaaagcgc cgcaaatcga tcttgatgta gagctgtctc gtcaaaaagc 607261 actgcttgac gcgattaaaa aaggcttcgt tcaatctgcg catgatgtgt ctgaaggcgg 607321 cttaggcgta gcgattgcgg aaagtgtcat gacgacggaa aaccttggcg ctaatgtgac 607381 tgtagaaggg gaagcggcgt tattattctc tgaatctcaa tctcgcttcg tcgtttcagt 607441 gaaaaaagaa catcaagctg cgtttgaagc aactgtcaaa gatgcagttc atattggtga 607501 ggtaacagct gacggaattc tggcgattca aaaccaagac ggacaacaaa tgattcatgc 607561 gcaaacgaaa gagcttgaac gcgtatggaa aggagctatc ccatgcttgc tgaaatcaaa 607621 ggcttaaatg aagaatgcgg cgtttttggg atttggggac atgaagaagc cccgcaaatc 607681 acgtattacg gtctccacag ccttcagcac cgaggacagg agggtgctgg catcgtagcg 607741 actgacggtg aaaagctgac ggctcacaaa ggccaaggtc tgatcactga agtatttcaa 607801 aacggcgaac tcagcaaagt aaagggaaaa ggcgctatcg ggcacgttcg gtacgcaacg 607861 gctggaggcg gcggatacga aaatgttcag ccgctcctct tccgttccca aaacaacggc 607921 agcctggcgc ttgctcataa cggaaatctt gtcaacgcca ctcagctgaa gcagcagctc 607981 gaaaatcaag ggagcatctt tcaaacctct tcggatacag aggttttggc tcacctgatc 608041 aaaagaagcg gacacttcac gctgaaggat caaattaaaa actcgctttc tatgctgaaa 608101 ggcgcctacg cgttcctgat catgaccgaa acagaaatga ttgtcgcact tgatccaaac 608161 gggctgagac cgctatccat cggcatgatg ggcgacgctt atgtggtcgc atcagaaaca 608221 tgcgcatttg acgtcgtcgg cgcaacgtac cttcgcgagg tagagccggg agaaatgctg 608281 atcattaatg atgaaggcat gaaatcagag cgtttttcca tgaatatcaa tcgttccatt 608341 tgcagcatgg agtacattta tttctccaga ccagacagca atattgacgg tattaatgtg 608401 cacagtgccc gtaaaaacct tgggaaaatg ctggctcagg aatccgcagt tgaagctgac 608461 gtcgtaaccg gggttccgga ttccagtatt tcagcggcga tcggctatgc agaggcaaca 608521 ggcattccgt atgagcttgg cttaatcaaa aaccgttatg ttggcagaac gtttattcag 608581 ccgtcccagg ctctgcgtga gcaaggcgtc agaatgaagc tgtctgcggt gcgcggggtt 608641 gtagaaggca aacgcgtcgt gatggtggat gactctatcg tgcgaggaac aactagccgc 608701 cggattgtca cgatgctaag agaagcgggt gcgacagagg tgcatgtgaa aatcagttca 608761 ccgccgatcg ctcatccgtg cttttacggc attgacactt ccacacatga agaactgatc 608821 gcgtcttcgc attctgttga agaaatccgt caggaaatcg gagccgatac cctctcattt 608881 ttgagtgtgg aagggctgct gaaaggcatc ggcagaaaat acgatgactc gaattgcgga 608941 cagtgtctcg cttgctttac aggaaaatat ccgactgaaa tttaccagga tacagtgctt 609001 cctcacgtaa aagaagcagt attaaccaaa taaaacttga aaaatgacat aaaggcagcg 609061 cagttcggct gcctttctct ttctgccctc gttcggggag atattttgaa aagcgcctta 609121 aaggagtgaa taggatgtct gaagcatata aaaacgcagg agttgacatc gaagccggat 609181 atgaagctgt aaaacgaatg aaaaaacacg tggagcgcac gaaacggctt ggcgttatgg 609241 gcagccttgg cggttttggc ggcatgtttg acctgtctga gctttcttat caaaaaccag 609301 ttctcatttc gggaacggac ggtgtcggca caaaattaaa gctcgctttt tccatggata 609361 agcatgacac gattggcgtg gatgctgttg caatgtgtgt caatgacgtg ctggcacaag 609421 gtgcagagcc gctgtttttc ctcgattatt tagcggttgg caaagcggac ccagtgaaaa 609481 ttgaacagat tgtacaaggt gttgcggaag gctgtgagca gtcaggttca gccttagtcg 609541 gcggtgaaac ggctgaaatg ccggggctct atacagctga tgaatacgat attgccggtt 609601 tctcagtcgg agtggcagaa aaggacgaaa tcgtgactgg agaaaaaatt gaagagggcc 609661 atctgttgat cggcctcagc tccagcggcc ttcacagcaa cggcttttcc cttgtcagaa 609721 aagtgcttct ggatgatgcg gagctggacc tcgatacaac atatgagccg tttgaacgcc 609781 cgcttggcga ggaattgctt gaaccgacaa ggatttacgt gaagcctgtg cttgccgcgg 609841 tcaaaagcgg aaaaatcgac ggcatggcgc acgtgacagg cggaggattt attgaaaata 609901 ttccgcgtat gcttccggaa ggcttaagtg cggaaattga tcatggctca tggccgatcc 609961 cgccgatttt ttctttcttg caagagtacg gcaagctaaa ggaagaagac atgttcaacg 610021 tctttaatat gggtatcggt tttgttttgg cagtcaaaga agagcatctg acagatgtga 610081 tcggaacgct tgaaagccat ggcgaaaaag cctatttaat cgggcgtgtg aaaaaaggtg 610141 aaggcgtcac attcggcggt gcggcacttt catgaaaaag tttgcggtat ttgcatcagg 610201 aaacggttca aacttcgaag ccatcgtcac gcgtttgaag gaggagaact gggatgcgtc 610261 agcagcgctc ctcgtttgcg acaaaccgca ggcgaaagtc atcgaacggg cggaagcatt 610321 ccacattcca tccttcgcat ttgagccgaa gtcttatgaa aacaaggctg catttgaaca 610381 agccatcatt gaacagcttc gtcttcacga ggttgaattg attgctcttg ccggctatat 610441 gaggctgatc ggtgatacgc tccttcaagc atatggggga aaaatcatta acattcaccc 610501 atcgcttctt ccggcgtttc ctggaatcga cgcagtcgga caggcgttcc gggcgggtgt 610561 gaaggtggcc ggaatcaccg tgcattatgt cgatgaagga atggatacag gtccgatcat 610621 cgctcaaaag gcaatcgaaa ttgatgaaca tgatacattg gaaacaatcg aacagcgaat 610681 tcacaagctt gagcataaat ggtatccgag tgtgattaaa cagctattag gattaaataa 610741 cagaggtgaa aaggcatgac cattaaacgt gcattaatca gtgtttcaga taaaacaaat 610801 ctcgttcctt tcgtaaaaga actgacagag cttggcgttg aagtcatctc cacaggcgga 610861 acgaaaaagc ttcttcaaga aaacggtgtg gatgtgatcg gaatttctga agtgacaggc 610921 tttcctgaaa ttatggacgg ccggttaaaa accctacacc cgaatattca cggcggcctt 610981 ctggcggttc gcggcaatga agagcatatg gcgcagatca atgaacacgg gattcagccg 611041 attgacctcg ttgtcgtcaa cctctatcca tttaaagaaa cgatttctaa agaagacgtc 611101 acgtatgaag aagcgatcga aaatatcgac atcggcggac ctggcatgct gcgcgcggca 611161 tcaaagaacc atcaggatgt cacggttatc gtcgatccgg ccgattacag cccagtgcta 611221 aatcaaatca aagaagaagg cagcgtatct cttcagaaaa aacgcgagct cgcggcaaaa 611281 gtattccgtc atactgcggc atatgatgca ctgatcgctg actatctgac aaatgttgtc 611341 ggtgaaaaag aaccagagca attcactgtg acatttgaga aaaaacaatc gcttcgctat 611401 ggagaaaacc cgcatcagga agcaactttc tatcaaacag ctcttcctgt caaaggctcc 611461 attgcgcaag cagaacagct tcacggaaaa gagctttctt acaacaacat taaagacgcg 611521 gatgctgcag ttcaaatcgt tcgtgaattc actgaaccgg ctgctgttgc tgtgaagcat 611581 atgaacccgt gcggcgtggg aacaggaaaa acgatcgcag aagcgtttga cagagcgttt 611641 gaagcggata aaacatctat cttcggcggc attatcgcgc tgaaccgtga agtggacaag 611701 gcaactgccg aagcgcttca caacattttc ttagaaatca tcattgcgcc ttcattcagc 611761 caagaagcgc tcgacgtcct gactgcgaag aaaaatctcc gtctgctgac gcttgacgta 611821 tccgccgctg ttcaaaagga aaaacagctg acatccgttc aaggcgggct gctgattcaa 611881 gatttagata tgcacggctt cgatgatgct gagattagca ttccgacaaa aagagagccg 611941 aacgagcaag agtgggaaga cttgaagctt gcttggaaag tcgtgaagca tgtgaaatca 612001 aatgcgattg ttctcgcgaa ggacaacatg acagtcggcg tgggagcagg ccaaatgaac 612061 cgcgtcggat cggcaaaaat cgcaatcgag caagcagggg aaaaagcgaa gggcagcgcg 612121 ctcggttcgg atgcatattt cccaatgcca gatactgtcg aagaagcggc aaaagcgggc 612181 gttacagcca tcattcagcc aggcggatcg atccgagatg aggattccat caaaaaagcg 612241 gatgaatacg gcattgccat ggtattcacc ggcatcagac acttcaaaca ttaaggggat 612301 gaaaacgacg tgaatgtatt aattatcggt aaaggcggaa gagaacatac gctggcgtgg 612361 aaggcagcgc aaagcagcct cgtcgagaat gtatttgccg ctcccggaaa tgacggcatg 612421 gcagcttccg ctcagcttgt aaacattgag gaaagcgacc acgcagggct tgtctcattt 612481 gcaaaacaaa atcaggtcgg cctgaccatt gtcggccctg aggttccttt aattgaaggt 612541 ctggtggatg aattcgaaaa agcgggctta catgtgttcg gtccgtcaaa agctgcggcg 612601 atcatcgaag gaagcaaaca gttcgctaag gatttaatga agaaatacga cattccgacc 612661 gcagaatacg agacgtttac atcctttgat gaggcgaagg catatgtgca ggaaaaaggt 612721 gctccgattg tgataaaagc agatggactt gcagctggaa aaggcgttac tgtggctatg 612781 acagaggaag aagcaattgc gtgcttgcat gactttcttg aagatgaaaa gttcggtgat 612841 gcgagcgcgt ccgttgtcat tgaagaatat ctttctggtg aagaattttc tctaatggcc 612901 tttgtcaaag gggaaaaggt gtatccgatg gtgattgccc aggatcacaa gcgggcgttt 612961 gacggagaca aaggcccgaa tacaggcggc atgggcgcct actcgccagt tccgcaaatt 613021 tcggaagaaa cggtccgcca tgctgtagaa acgatcgtta agccggctgc aaaagcaatg 613081 gtacaagaag gccgttcctt cactggcgtt ttgtacgctg gattgatgct tactgaaaac 613141 ggctcgaagg tcattgaatt taatgcccgt ttcggcgatc cggaaacaca ggtcgtgctt 613201 ccgcgcatgg aatctgatct ggtacaggtg cttcttgatc ttttagatga taaggaagtt 613261 gacttaagat ggaaggatac cgcggcagtg agtgttgtgc ttgcatcaga agggtatccg 613321 gaaagctatg caaaaggcac gccgatcggc agccttgcag cagaaactga gcaggtcgtg 613381 gtcttccatg ccggaacgaa agcagaaggt ggagagttcg ttacaaacgg ggggcgcgtc 613441 gccaatgtga cggcttttga tgaaacgttt gaagcggcta gagaccgagt gtacaaagcg 613501 gttgatgaaa ttttcaaacc gggactcttt ttcagaaaag acattggggc acgcgcttta 613561 aaggctgccc aaaaataagt gaggaaaacc cgcagaatag ctgcgggttt tttgttatca 613621 aaaagcggga tggcagctag aagaagaaag cacaacgagc gtggttggtt ttccatgggc 613681 catcgaggtg tcaataaaat cctcaagcgt atgtaccgat tcagtcacga cctttgtcac 613741 atagctgtac atccccgtga tgcggtggtt ttctgctaca tcaggatgcg atgttgcaaa 613801 ggcggcgtag tgcttgcagc ttttcggctc catgagaata aaagcggtga catgcttgtt 613861 tagtttttcg taacagatat tcgcgctgta gccggtaatc actcctttgt cttccagctt 613921 cctgacacgc tccgccgcgc ttggcgagct gagtccgaca agctttccca gctcaaccat 613981 cgttaatctg ccgtttcgct gcaaatgcga gagaatctga aggtctgtat cgtccatttg 614041 tctggctcct ttacatattt aggcgaatga atgaaaattc ctttgatcgt aaggtaatgc 614101 tgttgattta acttcattgt agcatatgga tgccgtctta ttttttctat aataaagcca 614161 tcaatcagag agggggcatc atgttgccag aattgcagcg ctctattact tggatacaag 614221 ggacggcgtt aacgattggg gcggttttag gatgcgggat attaatcctg ccgtctgtca 614281 ccgcggacac ggccggcccc gcttctttat ttgtttgggt gttcatgtcc ttcttatcct 614341 tttttcttgt cggcacgctg gcccggcttg tgaaaatagc gcctagcgcg ggaggaatca 614401 cggcttatgt gcagctggcc tttcagaaaa aagccggggc tattttgggc tggatcatgt 614461 tagggtccgt tccgatcggc gttcccatca tcgctttgac tggcgcgcat tacgtcagtt 614521 acatcacaga ggcggccgat tggcagatta cattgattgc tggttgcatg ctggctatat 614581 ctattttgct tcatatgaga gggattcaac tatcagcaaa cattagtaca ctcgttatat 614641 gtgtcatcgt atttctgctt gtcacttcta ttgctgtgtc attgccacac gtcacgatag 614701 cagaattcaa gccgtttctt ccgcatggct ggtctgccgc tggatctgtt tctgttatga 614761 tttttttctc ttttgtaggc tgggaaatga ttaccccgtt ggctgaggaa tttcatcgtc 614821 ctgaaaaaga tgtcccgctc agcttgtttt tggcagcgtc ttgtgtggcg gggctgtata 614881 tcatgctgtc atttgtgacc gtgggtactc attcatatgg agagaatgga gaaattgcat 614941 cgcttgccat gctcatttca aaaggagcag gagaaagcgg tgtatatgtc acggtatgtt 615001 tagcgctgtt tattacattc gccaccatcc atgccaatat tgccggtttt tcaagaatgg 615061 tgtacgcatt ggcgagagag gggcacatac ccgtattttt tggaaaactc agtgcgacaa 615121 aacgtacgcc tattcgcgtt ttgacagcga tggccgcagt gtttggctta gtgcttgcag 615181 cgcatggtct gtttcaaatc gatttgacga ctctgttgaa agggccgagc gcggctttta 615241 tcgcatctta catatgtaca atggcggcag cactgaaact gctgggcagg agagatatag 615301 gctggtggat ggcgctcggg gcatttgtgg cgtgcgcggt gatttattca ttcagcggct 615361 gggcactgct ttatccggca gtgctggcag ctgcaggata tttctatatg aaaacaaagg 615421 gtgggcataa aaaaaagctt gatcacgttt tgtgatcaag cttttccatt tatccgtttt 615481 gatgctcgtt atttccagaa tcgctgtgtt gaaacatgta ggtcacagga cagaagcgca 615541 agattcccga acccgctttc atggccccca taaagatgta aaagagatgc attctgcacc 615601 aaggtttttt cgtaaacttt gcactggcgg ctgacataat cgtcaatccg caggcgattc 615661 tgaacacggc attgatgaga ctgatgtttg gcttcaagga aatccgctcc ttttacttaa 615721 aaaagttttt taatcgaacc ttcaaaaatt tgtaacgttt ttatcgtgcg tgatgaggaa 615781 ggatgtgata ccatgagtct aatacatgta aaggagagta tgtgaatgtc cgaacgcacc 615841 tttaactgga aaaacaaaga catcagggca caggttgatg ttgtagactc aaagctgctt 615901 ccaacgctcc ttttacggaa tgctctcgtc ttaaatccat atgtaaaaca atggctgaaa 615961 aaaaacattt ggatttatca ggaccgcatt gtttatgtgg gtcatgaact tccgaataga 616021 gccgaagaaa ttcatacgat tgattgtgaa ggaaaataca ttgtgccagg ttatattgaa 616081 ccgcacgcac atccttttca aatatataat ccccaaacac tggcggaata tgtgtctcaa 616141 tacggaacaa cgacattcgt gaatgataac ttatttttgc ttttgcaaag cggaaaaaag 616201 aaagcgctta cgattttgaa tgaactcaaa aagcagcctg tccagtattt ttggtggtca 616261 cgctatgacc tccagaccga ggttctgaac gaggaccacg tccttccatt tgacgtcaga 616321 aaacagtgga ttgaacatcc ggatgtgatt caaggcggag aaatgaccgg atggcctcgc 616381 ctggtagatg gtgatgattt aatgctccac tgtatgcaag ctacaaagaa acagagaaaa 616441 cgtattgaag ggcattttcc cggcgcttct gataaaacgc ttacaaaaat gaagctgttc 616501 ggtgcggatt gtgatcatga agcgatgaca ggtgatgaag tgatgagaag gctggaactg 616561 ggctattatg tttcccttcg gaactcttcc attcgccccg atgtaagaaa aatcttgcaa 616621 gagctgcatg agaagggctt ccgctattat gaccacttct tttacacgac agatggcgca 616681 accccgaatt tctataaagg cggcatgaca aacgagctga ttcgcattgc gttagaagaa 616741 ggcgtacctg caatcgacgc ctacaatatg gcatcattta atatcgcaaa gtattaccaa 616801 atggatgatt atttaggagt tgtcggaccg ggcagactgg catcgctaaa catactggaa 616861 gatccgttaa atccgaatcc agtgactgtt ctgtcaaaag ggaccattct gcgtgaaaac 616921 ggctgtgatt tgaaggcgtt tacaaagacg gactggcaca aaggcggtct tgtcccgctt 616981 gagctttcat atgatatgac gatggatgac ttgcagtttt ctatgccgat gggcgtgaaa 617041 atgcggaatg cggttattat ggagccatat atgattgaga tcgacaattc gatggaacag 617101 ctctcgtttg accatgatga aagttatttg acgatgctcg acagacacgg gaaatggcgc 617161 gtcaatacga tgataaaagg gtttgcctca agcgtgcagg gatttgtaag ctcctttacg 617221 acgacgggcg acattgtcgc gattggaaaa aataaagcgg atatgctgct cgctttcgcc 617281 cgcatgaaag aaatcggagg aggaattgtt ttagcggaga acggaaacat tctgcatgaa 617341 atcccgcttg cgctgtgcgg ctgcgcctct tcggaagcgt atgaagacgt gcttgagaag 617401 gaacaaaagc tgagagatct tttgactgaa agaggctatg agttttgcga tcctatctat 617461 acgctgctct ttttgcaaag tacgcacctt ccgtatatac gcattacgcc aagaggaata 617521 ttcgacgtca tgaaaaaaac tgtactcttt ccatcgataa tgcgttaaaa tataaaagag 617581 cagggagccg acatatgaaa aaatggatga cagtttgcgc gctgtgtttc gtgttttttc 617641 tgctggtatc ctgccagcag aaggatgctg tcccggatac tgcaaagaag ctgaaagctc 617701 ctttaacggg gctaaagact gaacagaaag tgactgaacg ccgccctgtt gctgttgtgg 617761 tgaacaatca cccgaaggcg aggccgcagt cgggtctgtc taaagccgac attgtcatag 617821 aagcgctagc cgaagggcaa atcacaagat ttctggccat tttccaaagc cagatgcctg 617881 aaactgtcgg acctgtgcgg agcgcgcggg aatatttcgt cactctcagc aatggctttg 617941 acagcatatt tgtccatcac ggctggagtc ccggcgccaa aaagcagctg gaatccggag 618001 ctgccgatta tatgaacgga ttggattttg acggaagctt attttggaga gctgatttca 618061 gcaaaccgcc ccacaattcc tatacgtctt atgattacat aaaaaaggcg gcagaacaaa 618121 agggttataa gctgaagcag gaaacaaatc cgctgctgtt tcaaacatca gatgcaaaac 618181 ctgcaaatga atcttacaat gttcgggtag attatggaac aaataacgtt acaaatcttg 618241 tcgaatacaa ctatgataaa aaagctgaat tttatacaag aagctctgat ggtgtcataa 618301 cgacagaccg ggaaaccgga aagccggttg caatgcaaaa tattttcatt gttgaagcca 618361 gccatcatat tattgatcaa gatggaaggc gggacatcga cttggaatca ggaggaaaag 618421 gtctgttgtt tcagcacgga aacgtcattg aaacagactg gaaacaagtg aatggcagaa 618481 ttgtgccggt aaaagacggc aagtggcttc cgtttgtgcc aggaaagact tggatcaata 618541 tcgtacctga tcttgatgcg gcttccatta gtaaaggaga aggtgtgtaa cgatgcaaat 618601 cgataaatta cgcggcaaag agctggacca gttatttaac tcgatcttat cgctgaaaga 618661 cctggaggaa tgttaccgat tcttcgatga tctatgcaca attaacgaaa ttcaatcgct 618721 ggctcagcgc cttgaagtgg cgcgcatgct tcgcgaagga aacacgtatc ataagattga 618781 aacagaaaca ggcgcttcca cggctacgat ttcccgtgtg aaacgctgct taaattacgg 618841 aaatgacgct tatgaaatgg cgcttgaccg tgtgaaggag acggaaacag agtcttcttc 618901 caaataaaaa accgccctgc cgtctggcaa gggcggtttc tttatgaaac aaattgatgg 618961 atcaggttgt cgatattgat gatactgcca tcctctttcc gatagacaac atgctccttg 619021 gaaaaatgaa tcggcgaatt aatccctgct gcggctgcaa ggttaaatag tccctcgcgc 619081 aatgaaataa cgtagttgca gacacgatgc tgtttttcct caacgctcag tgctttttgc 619141 aatttcggat ctgtcgtcgc cacacctgcc ggacaggtgt tggtgtggca gacgagagcg 619201 cggatgcagc caacggaaaa catcatgccg cgtgcgatgt taacaaagtc agcgccgagg 619261 gctaaggcga ccgcgatttt atcaggagtc aggagctttc cggaagcaaa gattttcagc 619321 tggctgcgca agccgtactg tttaagaagc gtgtccacaa taggcagcgc tgtcataatc 619381 ggaaggccga ctgtatccgc gagctcgtaa aaggaagctc cggtaccgcc ttcacttccg 619441 tcgatcgtga taaaatccgg atgctttccg cttttctgca tatgagagaa aagctcatgc 619501 aattcttcag gatgccctgc gaccagtttg atgccgactg gcttttgtcc gacatctcta 619561 agtttttcaa taaagtcgag catttcagga gggtttgaga attcataaaa gcggttcggg 619621 ctgtcaatcg actttccagg ttcgacattc cgaatgtctg ccacttcctc tgatactttg 619681 gcgccgtcca catggccgcc gcgggttttc gctccttgtg ccagctttag ctcaaacgct 619741 ttaatctggt caatcctgct ttttctttta aattcctccc acgaaaattc cccgtttctt 619801 ttgcgcacgc cgaataggcc cggtccgatt tggcaaatga tatcggcgcc gccctttaag 619861 tgatattcag acaatccccc ttcacctgta ttcatccagg tgccgcctgc cagatggagc 619921 ccttttgaga gcgccgtaac agcccgttct ccaagagaac cgtagctcat ggcagactgg 619981 ccgactaagc ccttcacata aaatggcttc tcgcatgtat gctcgccaat cacctgtaca 620041 tcatcaggat ggagaaaata cgggtctgcc ttgatatgtt cggcatgctc cttgcgtttg 620101 aacagattgt cagcatccat tttatagatt tgggtttcaa tttttggcgt ttgatttaca 620161 tgcatttctt ccctttgttt tggaaacata gcgttacgga tataatagcc aggtttatca 620221 aaatctctta cagatccaaa gcccatcatt ctgcttttgt atttgccgga gatgacggtt 620281 tgctcatatt cctttcgtga aaatggctgc tcttcattgt cattgctgta taaatactgt 620341 ctgagctccg gcccgatttt ttcaaggata taccgaaacc ttccgatgac gggatagttg 620401 cgaagaattg agtgctcctg ctgtttttca tcctttatgt agatccaggc aaacaagacg 620461 atcgggatag cgatgatccc aatgataaat gcgatgagtg ctattatgat ggtttccatc 620521 tctcagcctc cctttttatg taaccatttc cacagtagaa cactttccaa acaatagcag 620581 aaggaatctg gtgaaaaatg tgtgctcctg ccgatacagg actcaccatg caggtactgc 620641 catatgctct ctttttttat gaaaaaagaa tcaaaacacc tttttcagtg aataacgaga 620701 ttaacggctt tttccgtttt tccgcgctat gtgaatttgt tataatgttt aaatggtaac 620761 aaacgaatgg aggaacgtat gacgtgtacg atgtaacgga gtggaagcat gtctttaaac 620821 tcgatccaaa taaagatttg cctgacgaac agctggagat tctttgcgaa tcaggaacgg 620881 atgcggtcat tatcggagga agcgatggtg tgacagagga taatgtcctg cggatgatgt 620941 ctaaggtaag acggtttttg gtgccgtgtg tcctagaggt atcagcgatt gaagcgattg 621001 ttcccggctt tgacttatat tttattccga gtgtattaaa cagcaaaaac gcggattgga 621061 ttgtcggaat gcaccagaaa gccatgaagg aatacggaga actgatgtct atggaagaaa 621121 tcgtggcgga gggctactgc atcgcaaatc cagattgcaa agccgcggca ctgactgaag 621181 cggacgccga tctgaatatg gatgatattg tcgcctatgc gcgtgtgtcg gagctgctgc 621241 aactgccgat tttttattta gaatacagcg gcgtgcttgg agacatagaa gctgtcaaga 621301 aaacgaaggc tgtattggaa acgtccacct tgttttacgg cggcggcatc aaggatgcgg 621361 aaacggccaa gcagtacgca gagcatgcgg acgtgatcgt tgtaggcaat gcggtgtatg 621421 aagattttga cagggctttg aaaacagtag cggctgtgaa aggcgagtag taaattgtac 621481 ggatttggtt tatgatagaa cgtatgtttt gtataggcgg gtgaacaaat tttgaattat 621541 attagcaatc aattactaag cggtttaaac cccgttcagc aggaagcagt caaaacaacg 621601 gacgggcctc ttttgctgat ggcgggagcg ggtagcggaa agacgcgtgt cctgacccat 621661 agaattgctt atttaatggc agaaaagcat gtggcgccgt ggaacattct ggcgatcaca 621721 tttacaaata aagcggcacg cgaaatgaaa gaacgtgtgg aaagcatcct cggacccggc 621781 gcggacgata tctggatctc cacattccac agcatgtgcg tgcggatctt gcgcagagat 621841 atcgaccgga ttgggatcaa ccgaaatttc tccatccttg atacggctga ccagctttca 621901 gtgatcaagg ggattttgaa ggagcgcaat cttgatccga agaagtttga cccgagaagc 621961 atcctcggca cgatcagcag tgcaaaaaac gaattgaccg aaccggagga attctctaaa 622021 gttgctggcg gctactacga tcaggtggtc agcgatgtat atgctgatta tcagaagaag 622081 ctattgaaaa accagtcgct cgatttcgac gatttaatta tgacgacgat taaactgttt 622141 gacagagtgc ctgaagtgct tgaattttat cagcgcaaat tccagtacat ccacgttgat 622201 gagtatcagg atacgaacag ggcacaatac atgctcgtta agcagcttgc cgagcgtttc 622261 cagaaccttt gcgttgtggg ggattctgat cagtcaatct acagatggcg cggcgcggat 622321 atcaccaaca ttctttcatt tgaaaaagat tatccgaatg caagcgtgat tttgctagaa 622381 caaaactatc gttcaacgaa acggattttg cgcgcggcta acgaggtcat taaaaacaac 622441 tctaaccgca aaccgaaaaa tttgtggacg gaaaatgatg aaggcatcaa gatttcctat 622501 tatcgcggtg ataatgagtt cggtgaagga cagtttgtgg ccggcaaaat tcatcagctt 622561 cacagcacag gcaagcggaa gctgtcggat atcgccatat tataccggac aaacgcgcag 622621 tcccgtgtga ttgaggaaac gcttctcaaa gcgggcttga actataacat tgtcggcggc 622681 acaaagttct atgacagaaa agaaattaaa gacattcttg cgtacctgcg cctcgtatcc 622741 aatccggatg acgatatcag tttcacgcgc attgtcaatg tgccgaagcg cggagtcggc 622801 gcgacatcac ttgaaaaaat cgcttcgtat gcggccataa acggcttgtc ctttttccaa 622861 gcgattcagc aggttgattt tatcggcgtc agtgccaaag cggcaaacgc gcttgacagc 622921 tttagacaga tgattgaaaa cctgaccaat atgcaggatt acttatccat tacagagctg 622981 acagaagaaa ttcttgataa gacggaatac agagaaatgc tgaaggctga gaaatcgatc 623041 gaagcccaaa gccgtttaga aaatatcgac gagttcctgt ctgttacgaa aaactttgaa 623101 cagaaaagtg aagacaagac actcgttgcg ttcctgacag acttggcatt gatcgcagat 623161 attgatcagc tcgatcagaa ggaggaagag tcaggcggca aggatgcgat caccctgatg 623221 acactgcacg ccgcgaaagg actggagttt ccggttgttt tcttgatggg gcttgaagaa 623281 ggcgtcttcc cgcatagccg ttcactcatg gaggaagcgg aaatggaaga agaacgccgc 623341 cttgcgtacg ttgggattac aagggcggaa caggagcttt atctgaccaa tgctaaaatg 623401 cgcaccttgt ttggccggac aaatatgaac ccggaatctc gcttcattgc tgaaataccg 623461 gatgatttat tggaaaacct aaatgagaaa aaagaaacaa gagcgacgtc tgcgagaaaa 623521 atgcagccga gacgcggccc tgtttcacgc ccggtatcct acgccagcaa aacaggcggc 623581 gacaccttga actgggcagt cggagataag gcgggccata aaaaatgggg aacaggaact 623641 gtcgtcagcg tgaaaggcga aggagaaggg acagagcttg atattgcctt cccgagccct 623701 gtcggcgtga aacgcctgtt agcagcattt gctcctattg aaaagcagta attgaagagg 623761 aaaggaagaa gcagatggac aaagaaacag cgaagcagcg ggcagaagaa ctgcgccgca 623821 ccatcaacaa gtatagctat gaatattaca ccttagatga accgagcgtc ccagatgccg 623881 aatacgacag attgatgcag gagctgatcg cgatcgagga ggagcaccca gacctcagaa 623941 cgcctgactc tcctacgcag cgcgtcggcg gagccgtgct tgaagcgttt cagaaagtca 624001 cccacggcac accgatgctc agtctgggca acgcctttaa tgctgatgat cttcgtgatt 624061 tcgaccgccg tgtgcgccag tccgtcggcg acgatgtggc gtataatgtg gagctgaaaa 624121 tagacggtct tgctgtttct ctccgttatg aagacggcta ttttgtcaga ggggccacaa 624181 gaggtgacgg gacgacggga gaggatatca cggagaatct gaagacgatc cgcaatatcc 624241 cccttaaaat gaaccgtgag ctgtcgatcg aagtgcgcgg cgaggcgtat atgccgaagc 624301 gttcgtttga agcactcaat gaggaacgga ttaaaaatga ggaagaaccg ttcgccaatc 624361 cgcgaaatgc cgcggcggga tctctcagac agctcgatcc gaaaattgca gcgaaacgaa 624421 acctcgatat cttcgtctac agtatagcgg agcttgacga gatgggtgta gagacgcaaa 624481 gccaagggct tgattttctc gacgaactcg gatttaaaac gaatcaggaa cgaaaaaaat 624541 gcggcagcat agaagaagtc attacgctga tcgatgagct tcaggcgaag cgcgcggacc 624601 tgccgtacga aatagacggc attgtcatta aagtcgattc tctcgatcaa caggaggagc 624661 tcggttttac ggcgaaaagc ccgcgctggg ccatcgcgta taagtttcct gctgaagagg 624721 tcgtgacgaa gcttctcgat atcgaattaa atgtcggcag aacgggtgtg attacgccga 624781 ctgcgattct tgagccggta aaagttgccg gcacaacggt ctcaagagca tcccttcata 624841 acgaagattt aattaaagag aaggacattc ggattttgga taaggttgtc gtcaaaaaag 624901 cgggcgatat catcccggaa gttgtgaatg tcctcgttga ccagcgcaca ggagaagaaa 624961 aggaattcag catgccgacg gaatgtcctg aatgcggcag tgaactcgtc cggatcgaag 625021 gagaagtggc gcttcgctgc attaaccctg aatgtccggc gcaaatccgg gaagggctta 625081 tccatttcgt ttcccggaat gccatgaaca ttgatgggct cggcgaacga gtgatcacac 625141 agctgtttga ggaaaacctt gtccgcaatg tggcagattt atataagctg acgaaggaac 625201 gagtcatcca gctcgagcgc atgggcgaaa agtccactga aaacctgatc agctccatcc 625261 aaaaatcaaa agaaaattcg ttagagcgcc tgctgtttgg gcttggcatc cgttttatcg 625321 gatcaaaggc cgcaaagacg cttgccatgc attttgaaag cttggagaac ctgaaaaaag 625381 cctctaaaga ggaacttctc gcggtagatg aaatcggtga aaaaatggct gatgctgtga 625441 tcacctattt tcataaagaa gaaatgcttg aactcttgaa tgaacttcag gagctgggcg 625501 taaacacgct ctacaaaggc ccgaaaaaag taaaagcaga ggacagcgac tcttactttg 625561 ctggtaaaac aattgttctg acaggaaagc tggaagagct gtcaagaaac gaagccaaag 625621 cgcaaatcga agcgctgggc ggaaagctga ctggaagcgt cagcaaaaac acagacttag 625681 tcatcgccgg agaagcggcg ggaagcaagc tgacaaaagc acaagagctg aacattgaag 625741 tgtggaatga agaacagtta atgggagagc taaagaaata agaggagtgt tttctattga 625801 aaaagacgtt ggcattggcg gcaacggcgg cagtattaat gctgtctgcc tgctcgtcag 625861 gtttcggggg ggagaaggag gaagagatta cgcaaaagac ggcgaaatcg tcagaaaaag 625921 cgattgtccc gaaatataat atctctgact cctattacaa aatggtgctg ccgtttaagg 625981 caggcaaagc gcgcggctta acaacggaac agctgaatac aaggctggac attgacgaat 626041 ttgaaacagg gctgatgcgc cttgcccaag attctttctc aactgacgat tatctgttcc 626101 aagaaggaca atatttagat gaggatacag tattaagctg gctggcacgg aaaaaaacgg 626161 gctctgattt gaaaaaagcc gaaaaagaag ataagaactt caaaaatgaa ggcttgaacc 626221 cggcgctccc gagttctggt tcaacagaag aaaagaacga aagcagccca atttatttag 626281 catccatgct tgagcacgat tatttagtca gaaaagacaa gaattctatc cagcttggcg 626341 gcgtcatgat cggactggcg ttaaactcag tgtattacta tcgtgaaaaa actggcgacc 626401 cgcaaaaaga agtggagatt aaagacagca cgcttcgcca gcagggagaa aaaattgcac 626461 aggaggttat taaccgcctc cgcaaaaaag ataacttgaa gaatgtgccg attaccgtgg 626521 cgctctacaa gcaggcgtca aaaacatcga ttgtgccggg gaacttcatc gccaaaacag 626581 aggtcaaagc aggctctact gatatctcaa attgggatga catcaatgaa aaatatgtat 626641 tctatccggc ggatacaacc acagcagaaa agtacccgga tgacaccgag gtctttaagc 626701 ggttcaaaaa ctcaattgaa gaatatttcc cgaactatac aggcgttgtc ggtacagcgc 626761 tgtatgaaaa tgatgaaatg aagaaaatga agattgacat accaatgcaa ttctacggaa 626821 aaagtgaagt tgtcgcgttt acccagttct taacgggtga agtgatggac tactactcta 626881 agagctcagt tgatgtcgaa gtcaatatca cgtcctcaga cggacaggaa gcggtcatta 626941 tccgcaatgc cggagataaa gagccgactg ttcacattta tgactgatag aaaacccttg 627001 tgccatattg gcacaagggt ttttatgtta caattaacag gaaaagggaa aatattttca 627061 cttctgccga aacacaaatc aaggggaggt atgttgatgc tggaaatcgt gtgaaaacaa 627121 tcattatcaa atctatagca atgaaaggat gttagacgtg cataaagata tcaaaaaaat 627181 atttcatgaa gagcaggttt tggcagaagc tgcagcgaga tacggtttct caaaagatca 627241 ggtgcgtttt ctggctgatg cggaaaacta tgtatatgaa tgtatgaaag acaatcaacc 627301 ttatatttta aagattaccc atacgattcg gagatcttct gattatatga tgggagagat 627361 ggaatggctc cgtcaccttg caataggggg aatttcagta gccaaaccgc tcccgtcgct 627421 gaacggaaaa gacgtagaag cagtgccgga cggaaacggc gggtcatttt tattgagagt 627481 gtatgagaaa gcgccggggc aaaaagtgga tgaatcggac tggaatgaaa cgctatttta 627541 tgagcttggc agatacacag gcagcatgca cagcctgaca aaaagctaca aattgagcaa 627601 tcccgctttc aaaagacagg aatgggatga agaggagcaa ttaaagctga gaaaatatgt 627661 gcctgaagat cagataaagg tgtttcagca agccgattct ttgatgaatg aactgcggag 627721 gctcccgaaa agccaggaca actacggctt ggtgcatgcg gatctgcacc atggcaattt 627781 taactgggat catggcaaaa tcacggcatt tgattttgat gatatcggct acaactggtt 627841 tgttaacgat attagcattc ttctctacaa tgtcctgtgg tatcctgttg tgccatatga 627901 tgataaagct gcgtttacag aagaatttat gacgcatttt atgaaagggt actgggagga 627961 aaatgagctt gaccctgcat ggctgatgat aatacctgat ttcctccgcc ttcgccatat 628021 gctgatttac ggattgctgc atcagatgtt tgaccttaac acaataggag aagaggaaaa 628081 agaaatgctg gccggtttca gaagagatat agagaatggc acgccgatta cagcatttga 628141 tttttcagca ctggtgtaga tagaaaaagc caatgggatt ccagtcccat tggcttttat 628201 aatgtatcac acttcacgcc gactacgcct tcaatggctt taatgtcata gtagacatcg 628261 gtcgtgtatc tgtttttatg gacgcggacc ttcacttcca taattggaaa atccttttcg 628321 cctaggtcgt cgatccgaac ggagtgtgct ttgatatctc ttcttttcat ttcttttaaa 628381 atctctgtca ttttgtcttt atcagaaagt gacattctga tgcggatgtc tttttcctgc 628441 aggcggtcgg ggccgatttt tctgaccacc catgggagaa attccacact gatcaggatg 628501 aacagaagac tggcaaacgc ttctttataa aaaccggctc ccgtagcaag cccgagcccc 628561 gctgcccccc agatcatggc cgatgtcgtc aggccggaaa tgacatcatt gctttttcgc 628621 aggatgacac cggcgccgat aaacccgacg ccggagatga tttgtgccgg cagacgaagc 628681 ggatccatca tgatgcggta gtatttaggg aaatgatatg ccgcattaat actgacgatc 628741 gtcagcatgc atgagctgac tgcgatgaca atacaggttt ttaatccgag cggcttattt 628801 tttaattcgc gttcaagccc gatgaccatg ccaatcaatg tggcaatgcc caatttcaat 628861 aaaatatcag gatcaatata ccagctcaac agcaaacttc ccccttctct atggtgtttt 628921 taaataaata tgattttctc acagtattta tagcaaaaca agagcacaaa agccaccaag 628981 ctgcgcttga tggcttattg cttacttttt gcgttttaac agcttttcca tgacaccgaa 629041 taatcggtaa gaggcttttg caggacgttt tgtgatcatg ctgacaatga tgccggcaat 629101 catactgaga ataaacccag ggatgatttc gtacacaccg gttgattttg ccaggccggt 629161 tgtaatccag atcaacacgg tcgcagcccc gacaatcatg gcagcaagcg cgccccattc 629221 gttcattcgt ttccaataca gactgagcag aatcgcaggc ccgaaagctg aaccgaagcc 629281 ggcccaagcg tatccgacca aatcaagaat ggtgctgttc gggttcaatg acaagagtac 629341 cgcgataacg gcaatgacta agacggacaa tcgcccgatc atgaccaatt ctttatcaga 629401 agcttttcgt ctgaaaaatg accggtataa atcctctgtt acagcacttg ctgtgaccaa 629461 gagctgtgag gaaatcgaac tcatgatggc agccaaaata gctgacaata agaaccctgt 629521 aattaatggg tggaacaaga ttttagagaa gataatgaaa atcatctccg gatcttttac 629581 agcaactccg aatttatggg cgtatgcaac accgattaaa cccgtcagca cggaacctag 629641 aactgtaatg atcatccagc tcatgccgat tcggcgtgca ggttttaaat ctttaatgtc 629701 tttaatggcc ataaatcgga cgatgatatg aggctggccg tagtagccca acccccaggc 629761 taaataggaa ataatgctaa tgacgctcgc gcctttaaaa atatccaata aatgtggatt 629821 aacagcgtcg atttcatgga aagtcggagc aacgccgccc acatgggtaa aagcaacgat 629881 cggcacaagc actagtgctg caaacatgat cgcaccctgc acgaagtcag tcagactgac 629941 agcaaggaaa ccgccaaaca gtgtgtataa cacgacaact gcggtggtca gaaacaggcc 630001 taatttgtaa tccgcaccaa aagcagattc aaacagccgt ccgccagata ccataccgga 630061 agaggtatac aatgtgaaaa agatcatgat gatcaatgca gatacgattt tcagcagtga 630121 tgaagaatgc tggaatcgtt tatcaaagaa atcaggaatt gtaatcgcat catctgccgc 630181 ttctgtataa gcacgcagcc ttggagccag cagcaagtaa tttgagtacg ccccgattgt 630241 aagacctaaa gcaagccata aggtggacag ccctgtcgca aacatcgcgc cgggaacacc 630301 catcagcatc catccgctca tatcggccgc gccggcagac aaagcagtaa cgaatggtcc 630361 gaggcctctt cctccaagca tgtaatcatt gatgtcagtg gttttcttga atgcatacca 630421 gccgattaac agcatggcaa taaagtaaat tcctaaagat ataataattt caatactcac 630481 gttttaccct ctcttcattt ctaataatgt tgcatcacct ctcaaattga tggtgccagt 630541 taagcagcct ggcgtaagtg caaaacaaaa gaaattcttt tgcgggtgca cttggtaact 630601 taacctaaca aagtattccc ggccattcaa gcgatgaaac attgatcata agctggaaat 630661 accgttgcaa acctagaagg gaataaagaa taaaacgctt tcaaaaaata attaaagtaa 630721 aaatattcag aaaaatattt cgtttctcct tctcctcatt ttagtataaa atatataggg 630781 tattgtttcg aaaacacagg cctgtctcaa ggcgttttgt tgctttaaag ggcttgtttt 630841 tgatatgatc agtattatat gacttaacgg agaaatatgt ggaggtggat catatgtcac 630901 gaatttcaat agaagaagta aagcacgttg cgcaccttgc aagacttgcg attactgaag 630961 aagaagcaaa aatgttcact gaacagctcg acagtatcat ttcatttgcc gaggagctta 631021 atgaggttaa cacagacaat gtggagccta caactcacgt gctgaaaatg aaaaatgtca 631081 tgagagaaga tgaagcgggt aaaggtcttc cggttgagga tgtcatgaaa aatgcgcctg 631141 accataaaga cggctatatt cgtgtgccat caattctgga ctaaaggagg gacacaagaa 631201 tgtcattatt tgatcataaa atcacagaat taaaacagct catacataaa aaagagatta 631261 agatttctga tctggttgat gaatcttata aacgcatcca agcggttgat gataaggtac 631321 aagccttttt ggcattagat gaagaaagag cgcgcgcata cgcgaaggag cttgatgagg 631381 cggttgacgg ccgttctgag cacggtcttc ttttcggtat gccgatcggc gtaaaagata 631441 atatcgtaac aaaagggctg cgcacaacat gctccagcaa aattctcgaa aactttgatc 631501 cgatttacga tgctactgtc gttcagcgcc ttcaagacgc tgaagcggtc acaatcggaa 631561 aactgaacat ggacgaattc gccatggggt catctacaga aaactcagct tacaagctga 631621 cgaaaaaccc ttggaacctg gatacagttc ccggcggttc aagcggcgga tctgcagctg 631681 cggttgctgc gggagaagtt ccgttttctc ttggatctga cacaggcggc tccatccgtc 631741 agccggcatc tttctgcggc gttgtcggat taaaacctac atacggacgt gtatctcgtt 631801 acggcctggt cgcatttgcg tcttcattgg accaaatcgg accgattaca cgtacggttg 631861 aggataacgc gtttttactt caagcgattt ccggcgtaga caaaatggac tctacgagtg 631921 caaatgtgga cgtgcctgat tttctttctt cattaactgg cgacatcaaa ggactgaaaa 631981 tcgccgttcc gaaagaatac cttggtgaag gtgtcggcaa agaagcgaga gaatctgtct 632041 tggcagcgct gaaagtcctt gaaggtctcg gcgctacatg ggaagaagtg tctcttccgc 632101 acagtaaata cgcgcttgcg acatattacc tgctgtcatc ttctgaagcg tcagcgaacc 632161 ttgcacgctt tgacggcatc cgctacggct accgcacaga caacgcggat aacctgatcg 632221 acctttacaa gcaaacgcgc gctgaaggtt tcggaaatga agtcaaacgc cgcatcatgc 632281 tcggaacgtt tgctttaagc tcaggctact acgatgcgta ctacaaaaaa gcgcaaaaag 632341 tgcgtacgtt gattaagaag gatttcgagg acgtatttga aaaatatgat gttattgttg 632401 gaccgactac accgacacct gcgtttaaaa tcggtgaaaa cacgaaggat ccgctcacaa 632461 tgtacgcaaa cgatatctta acgattccgg tcaaccttgc cggcgtaccg ggaatcagtg 632521 tgccatgcgg attagcagac ggacttccgc tcggcctgca aatcatcgga aaacactttg 632581 atgaaagcac tgtataccgc gttgctcatg catttgaaca agcaacagac catcataaag 632641 caaaacctga actgtaaggg gtgaaaagaa ttgaactttg aaacggtaat cggacttgaa 632701 gtccacgttg agttaaaaac aaaatcaaaa attttctcaa gctctccaac gccattcggc 632761 gcggaggcga atacgcagac aagcgttatt gacctcggat atccgggcgt cctgcctgtt 632821 ctgaacaaag aagccgttga attcgcaatg aaagccgcta tggcgctcaa ctgtgagatc 632881 gcaacggata cgaagtttga ccgcaaaaac tatttctatc ctgacaaccc gaaagcgtat 632941 cagatttctc aatttgataa gccaatcggc gaaaacggct ggatcgaaat tgaagtcggc 633001 ggcaaaacaa aacgcatcgg catcacgcgc cttcatcttg aagaggatgc cggaaaactg 633061 acgcatacgg gcgacggcta ttctcttgtt gacttcaacc gtcaaggaac gccgcttgtt 633121 gagatcgtat cagagccgga catccgcacg ccggaagaag cgtacgcata tcttgaaaag 633181 ctgaaatcca tcatccaata tacaggcgtt tctgactgta aaatggaaga aggctcactt 633241 cgctgtgacg ccaatatctc tcttcgtccg atcggccaag aggaattcgg cacaaaaaca 633301 gaattgaaaa acttgaactc ctttgcgttt gttcaaaaag gccttgagca tgaagaaaaa 633361 cgccaggagc aggttcttct ttccggcggc gtcatccagc aagaaactcg ccgttatgat 633421 gaagcaacga agaaaaccat tcttatgcgt gtcaaagagg gatctgacga ctaccgttac 633481 ttcccagagc cagatctagt cgagctctac attgatgatg aatggaagga acgcgtaaaa 633541 gcaagcattc ctgagcttcc ggatgagcgc cgcaagcgtt atatcgaaga gcttggcttg 633601 cctgcatatg acgcaatggt tctgacgctg acaaaagaaa tggctgattt cttcgaagaa 633661 accgttcaaa aaggcgctga agctaaacaa gcgtctaact ggctgatggg tgaagtgtca 633721 gcttacctaa acgcagaaca aaaagagctt gccgatgttg ccctgacacc tgaaggcctt 633781 gccggcatga tcaaattgat tgaaaaagga accatttctt ctaagatcgc gaagaaagtg 633841 tttaaagaat tgattgaaaa aggcggcgac gctgagaaga ttgtgaaaga gaaaggcctt 633901 gttcagattt ctgacgaagg cgtgcttctg aagcttgtca ctgaggcgct tgacaacaat 633961 cctcaatcaa tcgaagactt taaaaacgga aaagaccgcg cgatcggctt cctagtcgga 634021 cagattatga aagcgtccaa aggacaagcc aacccgccga tggtcaacaa aattctgctt 634081 gaagaaatta aaaaacgcta ataaaaaagc agcccttaga ggctgctttt tttatggtca 634141 aattgagata aagacaagat gagggcccga agcctttcaa cttctttgtc gttggttccg 634201 gccaaattgg acagcatgcc tttaataatc ggcttgcgcg gtttatcctg agtcaattct 634261 tcctcgataa catcaagtga cacggtgata tcctcgggca gcgtgctgtt ttctttcact 634321 ttctgaatgt cctcaagcag ctggtctttt cccgcaggca tcgggttaaa aatgtctttt 634381 gatacaatcg gattgagtgc agaacggctc agcccctgta caagatcatc cagtctctca 634441 ataataaagg ctgagatttc ttctgcatcg atattaagct caccgttaaa taccatcacg 634501 ttcatatagg aatgcacaat gcctcttgcc atgatggaca gatctgcgac ataccgctcg 634561 attccttcgc cataggatac cagcaaggcg ttccggtaca gcttatccgt ctccatggtt 634621 actttgtaaa agtattgctt gatttcttga ttttccggaa tgatattttc ggtaagcaaa 634681 agaacgataa aatctttatg atcgcgaaaa tcctcaaatt gagcgccaat ttgctttttt 634741 aacacttcct taggcggctt tccggcgaga tcttcttcta tatttttcat tttgttcata 634801 gacataccga tataatattc acaggcagat aacagcagcg cttctttcga tttgaagtgc 634861 aaataaaaag cgcccttcga aatgccgcat tcactggcga tttcttggat cgtcgtagct 634921 gcgaatcctt ttttcgcaaa taaacgaatg ctggttttta tgattctctc ttttttttca 634981 ttcatgacgt gcttcccctt aatccttgaa aaatttagta aaattttctg gtatatgagt 635041 tgacgttgtt gcgttataac gtttagtatt atatagaatg accagtcagt caataaaaaa 635101 tgtaatggag gatatgatga accacgttat taatttcgtt ctgaaaaaca aattcgccgt 635161 atggctgatg acgattattg taacggcagc cggcttgtat gcgggtatga atatgaagca 635221 agagtctatt cctgacgtga acatgcctta cttgacgatc agcacgacat atccgggtgc 635281 aacaccaagc caagtggctg atgaagtgac caaaccggtt gaacaagccg tacagaactt 635341 ggacggtgtc agcgttgtga cgtcgacgtc ctatgaaaac gcatcgtcgg tcatgattga 635401 atatgattat gagaaagata tggacaaagc gaaaacagaa gcagctgaag cgttagaaaa 635461 cgtcaacctg cctgatgacg cgaaggatcc ggagatttca cgctacagct tgaactcatt 635521 cccgattctg acgctgagcg tgtccagtga taaagataat ctgcaagagc tgacgaaaca 635581 agtggaggac agcctcgttt ctaagcttga aggcatagaa ggcgttgcgt ccgtccaagt 635641 atcaggccag caggtggaag aggttgaatt ctctttcaaa gaagacaaac tgaaggaata 635701 cggccttgat gaagatacag tcaagcaagt gattcaaggt tcagatgtga caactccgct 635761 tggattgtac acattcggaa atgaagaaaa atctgtcgtc gtcagcggcg atattgaaac 635821 aattaaagat ttgaagaata tgagaatccc gacggcatct gcttcaagtg caggcagcag 635881 cgcagcatct caagcaggtg cgcagagtgc tcaagcagcc caaagcgcgc aagcggcagc 635941 acaggtgcag caaagcgcaa gcacagcagt gccgacggtc aagctttctg acattgctac 636001 aattaaagat gtgaaaaaag ctgaatccgt ttcacgcaca aatggcaaag acagcatcgg 636061 catcaacatc gtcaaagcaa acgatgcgaa tacggtagag gttgccgacg atgtcaaagc 636121 tgagctgaaa aagttcaaag aagaccataa aggcttcaat tacagcgcaa ctctcgacat 636181 ggcggagccg atcacacagt cagttgacac gatgttaagc aaagccatct tcggtgctat 636241 ttttgcgatt gtgattattc tcttattctt aagagatatc aaatcaacat taatttctgt 636301 tgtttcaatt ccattatcat tgctgatcgc actccttgtg ctgcagcagc ttgatatcac 636361 attgaatatt atgacgctcg gcgcaatgac cgttgccatc ggacgtgtag tcgatgactc 636421 catcgttgtg atcgagaaca tttaccgccg catgagactc aaagatgagc cgctccgcgg 636481 aaaagccttg gttcgtgaag cgacgaagga aatgtttaaa ccgatcatgt catcaacgat 636541 tgtgacaatc gcggtattcc tgccgctcgc acttgtaggc ggacaaatcg gtgaattgtt 636601 tattccattt gccttaacga ttgtttttgc gcttgccgca tccctagtga tttcaatcac 636661 gcttgtgccg atgctcgcac acagcctgtt caaaaaatca ttaaccggtg cgccgattaa 636721 agcgaaagaa cacaaacctg gcagacttgc aaacatctat aaaaaagtat tgaactgggc 636781 gctgagccac aaatggatca cgtctatcat cgcggttctg atgctccttg gaagcttgtt 636841 cctcgtaccg ttaatcggtg ccagctacct gccgtccgag gaagaaaaaa cgatgcagct 636901 cacatacagc ccagaaccgg gtgaaacgaa aaaagaagcc gaaaatgaag ctgaaaaagc 636961 ggaaaaaatc ctgcttgacc gcaagcatgt cgatacggtt cagtattcat taggctctgg 637021 cagcccgctt gccggaggag attctaacgg tgcgttattc tatatcaaat atgaaagcga 637081 cacacctgac tttgataaag aaaaagataa cgttctgaag gaaatccaaa agcaatctga 637141 ccgcggagaa tggaagtcac aggacttcag ctcttcaggc aataataacg aattaacata 637201 ctatgtgtat ggcgattctg aaaacgatat taaagacacg gtcaaagaca ttgaaaaaat 637261 catgaaagat gaaaaggatc tgaaaaacgt aaattcaggc ctttccagca catatgatga 637321 gtacacattt gtcgctgacc aagaaaaact aagcaagctc ggtttaaccg cgtctcaaat 637381 ttctcaggcc ttaatgtcac aaacatcgca agaaccgctc accactgtga aaaaagacgg 637441 caaagagctt gatgtgaaca ttaagacaga aaaagacgag tataagagtg tgaaagattt 637501 agagaataaa aagatcactt ccgcgactgg ccaggaagtc aaaatcggcg atgtggcaaa 637561 agtgaaagaa ggatcaacat cagataccgt gtcaaaacgt gacggaaaag tctatgcaga 637621 tgtcacaggt gaggttacct ctgacaacgt cacagccgta tcagctgcta tccagaagaa 637681 aatcgataag cttgaccacc ctgataacgt atcgattgac acaggcggcg tatcagcgga 637741 tatcgctgat tccttcacga agctcggttt agcgatgctg gcagcaatag cgatcgttta 637801 ccttgtgctc gtgattacct tcggcggagc actagcgcca tttgcgattc tgttctcatt 637861 gccgttcaca gtcatcggtg ccctggtcgg actttacgta tcaggtgaaa cgatcagtct 637921 gaacgccatg atcggtatgc tcatgctgat cggtatcgtt gtcacgaatg ccattgtctt 637981 aattgaccgc gtgattcata aggaagcgga aggcctgtct acgagagaag cgctcctgga 638041 agccggctct acacgactcc gtccgatcct gatgacagcc attgcgacaa tcggcgcctt 638101 gattccatta gccctcggct tcgaaggcgg aagccaggtc atttcaaaag gactcggcgt 638161 aacggttatc ggcggtttaa tcagttcaac gcttctgacg ctcctgatcg tgccaatcgt 638221 atatgaagta ttggcgaagt tccgcaagaa aaaaccggga acggaagaag agtaaaaaac 638281 aaaaagcctc agctctgctg aggctttcag cttgttgaaa aaccctcgca ttcgttgtca 638341 ggtctgcgcg tcggtgctca cgaattctac attcgctccg ctccaatgct cccccttcct 638401 agactacaag ggttttcaat caagctgaaa gaatgttaag gatgacaaaa gctcaaaaca 638461 agaatcagtt ttgagctttt gtgcgttttc acctgtaaga ttatgtacat tttgttgcga 638521 tttttttaac tcatagtata attaaaggtt gttagtgtaa aaatggatcg gatactctta 638581 agtaggatga tgagataatg aaacgtgcac gcataatata caatccgact tcaggacggg 638641 agatctttaa aaagcatctt gcccaggtcc tgcaaaaatt tgaacaagcc ggctatgaaa 638701 cctccaccca tgcgacgaca tgcgcaggag acgctacaca cgctgccaag gaagcggcat 638761 tgcgtgagtt tgacctgatc attgcggcag gcggagacgg aacgatcaac gaggtcgtca 638821 acgggcttgc gcctttagac aatcgtccga cactcggtgt gattcctgtc ggcacaacga 638881 acgacttcgc cagagcgctc ggaatcccac gcgaggatat tttaaaagcg gcagatacgg 638941 tcattaacgg cgttgcccgc ccgattgata tcggacaggt caacggccag tattttatca 639001 atatcgccgg cggaggccgt ctgacggagc tgacgtacga cgtgccaagc aaactgaaaa 639061 caatgctcgg ccagcttgct tattatttaa aaggaatgga aatgctgcct tcacttcgtc 639121 cgacagaagt cgagattgaa tatgacggca agctgtttca aggtgaaatc atgctgtttt 639181 tggtcacgct gacaaactcc gtcggcgggt tcgaaaagct cgcgccggat tccagcctga 639241 atgacggcat gtttgatttg atgatactaa agaaagcaaa ccttgctgaa tttatcaggg 639301 tcgccacgat ggcgcttcgc ggagaacaca tcaacgacca gcacattatt tatacaaaag 639361 cgaaccgcgt gaaagtcaat gtatcagaaa agatgcagct gaacctggac ggcgagtacg 639421 gcggcatgct gccgggcgaa ttcgtgaatc tgtaccggca cattcacgtc gtcatgccga 639481 aggagaaagc ggaacagttg gatgactaaa acttggcttg gtaagccaag ctcagaatgt 639541 tgacaaaatc ctaaaacagt tttcgtttta ggattttgtc atcttttcag cgtgattgaa 639601 aacctttgaa gtctaggaag ggcgagcatc ggagcacagc gaatgttgaa ttcgtgagca 639661 ccgaagcaca ggcctgacaa cgaatgcgaa ggtttgccta cacgctgaaa cttggcttga 639721 ataggccaag tttttctttc gcttaaaact agaggtgatt atagatgaaa atgaaacccc 639781 cagtagaaaa aaatgaatac tacgatgtga catttgagga tttgacacat gaaggagcgg 639841 gcgtcgcaaa ggtccaaggc ttcccgatct ttgtgccgaa tgccctaccc gaggaaaaag 639901 cccaaatcaa agtgacacgc gtcaaaaaag ggttcgcctt cggccgcctg attgagctga 639961 aggaagaaag cccgcataga acggacgccc catgcccgat ttacaaacaa tgcggaggct 640021 gccagcttca gcacatgacc tacgaaggcc agctcctgtt taaacagaaa caagtcaaag 640081 acgtcttaga acgcatcggc aagctggacc tttcaaaagt caccgtgcac ccgacactcg 640141 gcatggaaga cccgtggaac tacagaaaca aagcacaggt gccggtagga gaacgggaag 640201 gcggactcgt cgcgggattc tatcagcaaa gaagccatga catcatcgac atgagcgcct 640261 gcctgatcca gcaatccaaa aacgacgaag ccgttcaagc tgtcaaagac atttgcgcaa 640321 actacggtgt caaagcctac aacgaagaac gccacaaagg ctggctccgc cacatcatgg 640381 tcagatacgg cgttgttacg ggcgaaatga tgatcgtctt catcacaaga acaagcgact 640441 tcccgcacaa agcgaagatc atcgaagaca tcacagcgca attcccgcac gtcaaatcca 640501 tcgtgcaaaa catcaaccca aacaaaacaa acgtcatttt tggcaacgaa acaaacgtca 640561 tctggggcga agaatacatc tacgacctca tcggagacgt caaattcgcc atctccgcca 640621 gatcgtttta tcaggtcaac ccagagcaaa caaaagtgct ctacgacaaa gcgcttgagt 640681 acgctgagct tcaaggggaa gaaaccgtca tcgacgctta ctgcggcatc ggaacgattt 640741 ctctcttcct ggcaaagcag gcgaaaaaag tgtacggtgt agagattgtg ccggaagcaa 640801 ttgaggacgc gaagcgaaac gccgaattaa acggcaacac aaacgcagag tttgctgttg 640861 gagaagcgga aaccgtgatt ccaaagtggt acgaagaagg cattacagct gatacgctgg 640921 tcgtcgaccc gccaagaaaa ggctgcgacg aagccctcct gcggacaatt gtggagatga 640981 agccgaagcg ggtagtgtat gtgtcctgta atcctggcac gcttgcgaga gatttgcggg 641041 tgcttgagga tggcgggtac gtgacgcgcg aagtgcagcc tgtggatatg tttccgcata 641101 cgaatcatgt ggagtgctgt gtgttgataa aattaaaaga ataaatagtc aaaaatctat 641161 gctgatggaa ctgttggttc tctaaaacga taattgattt caatggttcc atttgcatgt 641221 acttctattt catctactaa caaatgaagc atttcggggg taagtgtacc ttccttcatg 641281 aatttatcta agctcttttt aaaatcaatt atttcttttt caatcttttg aaattctagg 641341 tccttagata gttggtgaag ggtagtttca aaatttgaaa tatcttcatt ggtgatattt 641401 atggctaatt ggtaatcttc tttagatata acaccattag caagagagat aactaaattg 641461 gatttatctc tctttttatc gtttaatttt tcattaattt cgattatctt agattcgatt 641521 ttttctttgt actttaacgc tttttcactt aattctttaa aataattttc cttactgaat 641581 ttcaaatata tcttatttag gttggttatt actttatcag ttaaatctat ttcacttacg 641641 taatgatcac tacatgcttt taaaccatgt ttattataac ttccacaaac ataacctttt 641701 cgattctttt taaaatgcat tgacctcctg caatctttgc aaaccgcagt atttgtaaag 641761 agatgtactt cagcttgagg tctccttctt tttctagtta ttaaaatctc ttgtacaata 641821 agaaagtctt ctaaaggtat gattggttcg tggctttttt caataattat ttggttttct 641881 aggttaactg accttcttct tttactggta acactcggtc tatattctct acattgttgt 641941 agtgtcccag tatagtgagg attttcgaga atttttctta ttgaagatcc gtgccatttg 642001 tcagtagcgt tctttttgcg ggcaagctgc gagggactag tgaccccttc gttatacaat 642061 ccccttgcta ttgcatcaaa gccttttcca gcaatatatt ctgaaaagat tctaatattt 642121 actattttct ctgcgtttgc tgaatttgag agagatatga ttgtagaacg aactcaagaa 642181 ggtaaaatgt tggccaagca gaatccggat ttccgagaag gaagacccaa aaagttcaca 642241 aagcagcaaa tcaatcatgc attaacatta ctagaaaatc attcgtataa acaagttgaa 642301 gatatgactg ggatatcagt ttctacactt gtaagagcta aaaagaagaa agctgctgaa 642361 gctataaatg gataaatatt gtgaattaat tattcaatat cttgagaaat ttttataaaa 642421 gtaatcaaaa gtttaatggg ggaaacgaaa tggcgctcat tgatttagaa gataaaattg 642481 ctgaaatagt gaatcgagaa gatcattcag atttcttgta tgaattactc ggtgtatatg 642541 atgttccacg agctacaatt acgcgcttga aaaaaggaaa tcaaaacctt acaaaacggg 642601 ttggtgaagt acacttaaag aataaggtgt ggtttaagga ggctaagaaa ggaaagctct 642661 ttgacgccct tattgatata gaacaacaag ttgaatatct ttcagctaag ccacgatatt 642721 tattagttac tgactatgat ggagtattag cgaaagatac aaaaacatta gaggctcttg 642781 atgttaaatt tgaagaactt cctcagtatt tcgatttctt ccttgcttgg aaaggtattg 642841 agaaagtaga gtttgaaaag gaaaaccccg ctgatattaa agcagccgaa cgttttgcac 642901 ggatatatga tgtacttcgt aaagaaaaca atattattga gactaataga gggttagatt 642961 tatttcttat tcgtttactg ttttgttttt tcgcagaaga tactgacatc ttcaaacgaa 643021 atagttttac gaatttaatt aagactttga ctgaagaaga tggttcaaat ctaaataaat 643081 tatttgctga tttatttatc gtgttagata aaaatgaacg agacgatgtt ccatcttatt 643141 taaaagagtt tccgtatgta aatggccagt tgtttactga accacataca gagttggaat 643201 tttctgccaa atccagaaag ttaattattg agtgcggtga attattaaac tgggctaaaa 643261 tcaatcctga tatctttggt tcaatgattc aagctgttgc ttctgaagaa agccgtagtt 643321 atttaggtat gcactacaca agtgtcccca atataatgaa ggttattaaa ccgcttttcc 643381 tagataaact taatcagtct tttttagatg catacgatga ttatacaaaa cttgaaaatc 643441 ttctaacacg aatcggcaaa attaaattct ttgatcctgc atgtggttca gggaactttt 643501 tgattattac ctacaaagaa ttacggcgta tggaaatcaa tattataaaa cgacttcaag 643561 aactcttggg agagtatctt tatgtacctt cagtaacttt atctcaattt tacggaatag 643621 agattgaaga ttttgcacat gacgttgcaa aattatcact ttggattgct gaacatcaaa 643681 tgaatgaaga attaaaaaat gaagttcata atgcagtacg cccaacgtta ccacttcata 643741 cagcagggga tattcgttgt gcaaatgcta ttagggttga gtggactgag gtttgtcccg 643801 cacaaggatc tgaagaagta tatgtttttg gtaatccacc gtatcttggt tcaaaaaaac 643861 aaaacaaaga acataaatct gatatgttat caatttttgg aaaagtcaag aatggtaaaa 643921 tgcttgatta tatttctgct tggttttact ttggtgctaa atacgcttca actacaaatg 643981 caaaagttgc ctttgtatca acaaattcag ttactcaagg ggaacaggtt tctatcttat 644041 ggaatgagtt attcaagttt ggaattcaaa tcaattttgc ctataaatct tttaaatggg 644101 cgaataatgc taaaaataat gctgcggtaa ttgttgtgat tgtaggtttt ggcccgttag 644161 ataccaaagt aaacaagtat ttatttgttg atgaaacgaa aaagctagtt tctaacatta 644221 gtccctattt aactgatggt gaaaatattc ttgtttcttc taggacgaag ccaatttcag 644281 acttacccaa actgcatttt gggaacatgc ctaatgatgg cggaggatta ctctttacca 644341 ttacggaata tacagacgca atcaataagt atcctgaatt agttccctat tttaaaaagt 644401 ttataggttc agtagagttt attaatggtg gtttacggta ttgtttatgg cttaatgaag 644461 caaaatatga aaaaataaag tctaatcctc taatacaaga aagaatctca atttcaaaaa 644521 atcacaggga aaaatcaaca gataaaggaa cgaataaact tgcattaact ccgtggaagt 644581 ttagagatac tcatgaaaca actaattatt ccattgttgt tccatctgtg tcttctgaaa 644641 atagatttta tattccaatg ggattagcag gtgcagatac aattttgtca aatctaattt 644701 atgtaattta cgatgcagaa atttaccttc taggcatttt gatgtcacgg atgcatatga 644761 cttgggtaaa agctgtagcc ggaagattaa aaactgacta taggtactct gcaggtttat 644821 gttataacac tttccctatt cctgaattat caacaagaag gaagaatgaa attgaagaag 644881 caattcttga aattcttgat cttcgtgaag agcagggtgg tacattagca gagctttata 644941 acccttcaac aatgccaatt gaattaaaag tagcacatga aaagttggat ggaattgtag 645001 aaagagcgta tcgtcaaaaa caatttgaat ctgatgaaga acgcttagaa gtattgctta 645061 aattgtatca agaaatgaca gaacggtagg tgtaaggtgt atggaaaata taattgaaat 645121 taattataac caaactggta aaagtaagaa aacaaatgaa tacggtatgc gtgaaatgca 645181 ggcaagagct tttgaaaaac gtaactcaca atatctctta gttaaagcac cgccagcttc 645241 tgggaaatct agagctttaa tgtttatcgg tttggataag ctcataaatc aaggtttgag 645301 gaaagtgatt gttgctgtac ctgaacgctc tataggttct tcatttaaaa atacggattt 645361 aaaaagttat ggtttctttg aaaattggaa agttgatcct agaaataatt taactgttgg 645421 cggagataac tctaaggtta aatcttttgt tcgttttatg gaatcggacg atcaggtgtt 645481 aatatgtacg cactctactt tgcgatttgc gtttgaaaaa attgatgata aagcatttga 645541 taattgttta cttgcaatag atgaatttca ccatgtatcg gcagatgtca attctcgatt 645601 aggtgaattg ttaagaagta ttattcataa ttcatcagca catattgtag cgatgactgg 645661 gtcgtatttc cgtggagatt ctgtaccaat tttattacca gaagatgagg aattatttga 645721 caaggtaact tattcctatt atgaacaact tgatggatat gaatatctaa agggatttgg 645781 tataggatat cacttctatc aaggccagta cacatcagct attaatgaag tattggatac 645841 aaataagaaa acaatcgttc atattccaaa tgtaaactca ggggaatcga caaaggataa 645901 gtacgatgaa gttggtaaga tacttgatat gattggtgaa gttgaatatc aagatgatga 645961 tactggaatt atttatgtta agcgacattc tgacggtaaa acattgaaaa ttgcagattt 646021 agtagatgac caagttggaa gagaaaatgt cgttgcgtat ttgcgtaata ttgaagccct 646081 agacgattta gatataatta ttgctcttgg tatggcgaaa gagggctttg actggccgtt 646141 ttgtgaacat actttgacag ttggttatcg tggctcactt acagaaatag tacaaataat 646201 tgggcgctgt acacgtgata gttacaataa aacctatgct caatttacca acctaatcgc 646261 aatgcctgat gcaaaggatg aagtagtgac ttatacagtg aatacaatgc ttaaagctat 646321 ttctgcctca cttttgatgg agcaggtcct tacacctgac tttaaattta aacgtagaag 646381 aaatgaaagt gaaaaatctt ctactacagg agaattattc gttaagggat tgaaagaacc 646441 atcaacagaa aatgtcaaaa agattattga aaatgatatt aatgatttaa aagcaaaaat 646501 catgcaagat tcacaagtcc aaaaaacatt tagtggagaa gtagatccca aagtattgaa 646561 caaagtgttg attccgaaag ttattcaaaa agtatatcca aatttatcag atgaggaaat 646621 tgaggaagtt agacagcacg ttgttctaga tacagttatg aaaggtgcta agtctgaagt 646681 tgtaggaagt aaagaattta taagaatggc agataagttt ataaacattg aggatttaga 646741 tatcaatctg attgattcca tcaatccgtt ccaaaaagca tttgaggttc tatcgaaaga 646801 attgaactca ccagtgctaa aactgattca ggaaactatt gatgcaaaac gtattaattt 646861 tgatgaagat gaactagtat tcatatggcc aaaggtttag gaattttatc gttcaactgg 646921 tagaagacct gattcaaaat ctgaagaccc acttgaaagg cgtatgggtg aagctgtatt 646981 atacatgcaa gagcttagga ggaaacgtga aaatggcaag taatagatac cattctatta 647041 atgaaatcat ggaaagtcag ctgttttacc aaatcacaac accacctaag aaaacacaaa 647101 aagcccagta tgatcctgaa gttgaaaagt ttttggagat tattgaattc gtcaaagaaa 647161 atgggcgaga accccaaaaa gtccctactg atttaactga aagaagttta gcaagtcgat 647221 taattgggat tcggaaagat cctgatcgta tggaatattt gaaagagtat gatgaaattg 647281 gattacttga agtaagatcg aaggaactaa caattcctaa aatttcttca attgatgata 647341 ttctaaaaag tggcttatct gcattattag gtgataattt aaataatgat ataactaggt 647401 caatttttga tacaagttca cttcaaaagg ttacgacaat gcctgaatac gttgcaaagc 647461 gtaaaaaaat aaaagatttt ggaaagtttg aagagctatt caagaagtgc cacaaggaaa 647521 ttacagaggg taaacgaaaa attttaactt tcaaaaatga acaagacata cagtcaaata 647581 gtttttatat attaaaagga gttcttcttt atgttgaaga tgtgggagaa cgtaaaaaag 647641 caaagggaaa aaccaatgct agacttcgat gtatatttga aaatggaacg gaatcagata 647701 tgttactacg ttccttatca gcggagttat ataaacatgg tagacgtgtg accgacaatg 647761 aagatacatt gttggataat gttagagaag atgatgtttc gactggcttt atttacgtac 647821 taaaatcttt gagtacagat ccgcaaatta gttccattaa gaatttatat aagatcggtt 647881 ttacaactgg ttcagtagaa aatagaatca ggaatgcaga aaatcaatca acttatcttt 647941 atgctccagt agaaattgta accacatatc aagtgttcaa tatgaatgct agcaaatttg 648001 agacggcaat ccatcatgcg ctagcaaata ataatttgga tgtttctatt ttgggggcaa 648061 atggaaagat gttagttcct aaagagtggt tcgttgtcac acttgaagat ttacaagctg 648121 taatagatga gattgtgatg atggttcatc tttatgacta aattagtata ttaggatttt 648181 agtattaata ataattttat agtagactat gaaaaaattt gatgccataa caataacttg 648241 ttccgctttg gagtttgtca caattgtaga attatgtgtt gcgagtatta ataggaaggg 648301 gttgagcgac cgcaaaaaaa attttcggtg ctgtccgcaa aagggagttt gggtgttttg 648361 cgttatattt ggttgtgtga aggttagcgg aaactcaatt cgtgaagtta ggattgcggt 648421 tattacgact gagtagtttc gtcatactct tttagcagtt tttctgtctt atgcatttct 648481 ttgagcatcg gattcatgta gtcgttagct gattctagat atgctctcgt cagagtgtct 648541 agtttatttc taactttaga gaggtcttct tcgaattttc catccgatga ttgaaggata 648601 aattcttttg cctcttcata tctttttaat atgtttttca ccattggagt tggattcttt 648661 tgatttattg tttttattac agtgattgtt aaatttattt gttttattaa ttcttttctt 648721 actgtcaagg tgatgctcct tttaaatctc tattctattt gagagttgct atatctgttt 648781 aatggtttga tagactactc atctttataa tttagagcaa tttttacaac ttgttccgct 648841 gtgtaatctt cattgctcca gaaaattaaa tcacttggtg ccggataagg aacatttttc 648901 tctaataaat cgagatattc actgactttc tcatcatcta atgttgggtt cattaattcc 648961 tttacaagaa agatcaactc ttcttttgtc agtttatcca ttgtttgccc tccaatagat 649021 tgtatctcca ttgattttac aaatgacttt atttcttctg ataatgttat aggttgtttg 649081 cataatgata gataattgtc ttgagaaaag ttagtctcat tatagagttt attaattgta 649141 tttataacaa tatattcata tggaaaacct ctaaaatatc tttattttag attggtttat 649201 aaaaaatagc tcagcagagt agggctgagc cattttttaa ttatagaccg aggtaactaa 649261 ttacaaattc tttatcatcc tcatcttcag gcaaaatacc aaggttttta tattcccata 649321 ttgcgattct ttcatatcca tctaattctg aggctaaaat atcatcataa ttataatcta 649381 attggaattc tccgctacga tccaatgtta gtgtaaggtt agtccaaaca tcatcgttat 649441 tatttctgtg ttcagttctt aattcttcaa aaagttctct tagttctctt aacaacgtct 649501 tgaaaatatc cttgcttacg ttgtaatggc taggtatatc ttgtgaataa ataatttgat 649561 tattttctgg tgttctgaaa tgaaaaagaa ccattgtgga atcatctaat acttctgcat 649621 aaagatatat ctttgtccat tcaccaggta tgatgtcatt gagtttttct ccaataagtt 649681 gatacaaatc ttgcatcttc ctagtttcca ttcttctaac ccccaggctg atttttaata 649741 gagacgctta tttcttttct gctcccaatt ttgtaggtta catcgaaata tgatggtcta 649801 agtgaatccc cagaatagac tggttctatt tgaactgcta cttttttagg tggttttttg 649861 cttagggctt ttgcccactc ctgctccatc tcataccatt tcccaccgct cctattaatc 649921 tgagaattca tcggcacgat attgtcaaac tggcctgagc ctttgaattg ggtggcgatt 649981 aaatggccgc cgtcatcgtc aggctttcgg tcctggggct ttccagcatt cgtttgtgca 650041 tattggtttc gtttcgcttc tcccagctgc aagtctgctt tgacacttgt aattctacca 650101 tagttgtcag tcgtgtacgt gtagccttct tttgttttgt agatgatatt aggcttcagc 650161 actttctttc tgctccatct tgcgaaatgc tcgccgtatt tgacggttac cggcggtaca 650221 tgtggcgctg gagttcgtct tccgcttgat gacgttccgt atggtttcgg caggatgacc 650281 ttggcgaatt tttgcagtcc ttctttaagc gtgaccccgt tgactgcgtt gtaaggaacg 650341 cctgccggca ctaaatcatg acggggatga tacgggagaa tatccgcaag tgtgagatct 650401 ccgatttgat ttaacttggt tttgacgtgt ttttttgata cttcaatgcc tgtgtttact 650461 ttttgtttga tgtgatcaac ggtttgtttt gagactgtta tggctttttg ggctgttgct 650521 gatttgcttg ctgctgtttt gactttggtc gtcactttgg cggctgtgcc agtttttgag 650581 acggctccta cgccttttgt gccgacaatt gatgtgacaa cagtgccaac cgcatatgac 650641 acccatcttg ctcttgagta ggtgtcacca ttcaccatgt ctttttgata cgattcttcg 650701 attgccgctg aaatggcttc atacgttttg atcgggtgag ccatcgctcc ggtaatcgct 650761 tcaacggttc ctcccggatc tgtgaccata tcccacaggc ctacgaccgc gtctttcccg 650821 gaatcataaa ggccgacggc aacccctttg aagcctgctt caagctcacg cgtgttttca 650881 atttgggtga agtatctctg ttgttcagct gtcagatttt catagccgat cgtttttgcc 650941 atttcgtaga attcatcggc atctgcataa tcgtagtttt tcagtctttc tttcagtttc 651001 tcaatctcgc gttccttcgc ttcctctttc ttaatcttca agtaagcctc agtccgcttt 651061 tcaatgtcgc cttttttctt atgtatgtca ctctcacggt acgccttggc gttgtagtgg 651121 atgggtgtgg cgtttttgcc tttacccgtt gcttcttgga gcttttggaa gtcggatttg 651181 atgaattgtt cgtttggttc agacagggcg tattctgttt tcaggtcttc gtccaaggcg 651241 tccaattttt ccagtgtttt tttgcgtttg tcgttggcat cggccagctc gtctttgaag 651301 gtttctgttg aaaacaggtc gagcgggagg atgtcgtcga tatcgtttag gatgtctttc 651361 atcgcttttt tctgttcgga catgatggat ttagattttt tattggcatt tgccagttcg 651421 tgctccagga aggattcttc gatgtatgcg tctgagaggc ctttgtcttc ggcggctccg 651481 gcgatgctgt tgaaaaatgc gattttcatg tcgatgtagt cgatccactg gtcggcgacg 651541 ccgacgtggt cgtgatagaa tgccttgatg ttgctggcgc cttttcctga gaattcactg 651601 tcactgagat cagcgactcc ttttaacgct tttctcaagt tgaccatttg cgttcttagt 651661 tctttgtact cttttgcacg gtctgtcgct tccgaaagca gtgttttcgc ttcaaatact 651721 ttcatgacca tttcccttct tttgttcgct caatatcaaa attttaccac gggtcgggat 651781 aaggtggggg tgagaacgtg ttttggtgga aaaatgagtc atttggcatg tgtctttatt 651841 cgtggaggga ttggaggaaa catggtcgaa atgatattga ttgctacaca ttttttggaa 651901 gtttgtattc tatattgttt tttaaggagc atgttgatga cgaaaaaacg gattacattt 651961 ggtttattag ttttaatggt atgtgtcatc ctgtttgttc tgtatgttca gttacgcaat 652021 aaagatagta ttcctgtcca atcttccgcc attcaccccg aagaagaccg catctttttt 652081 atttactcca atcctttcat aaaagaaagc gtgctgcttt caacctctac aggcgaacgg 652141 tttaacaggc gtacgtttaa ggtggcggat gtgccttata ttcaaacgaa atcttatgca 652201 tcaacagacc ttgtattatt ggcggaacac gagccttttt actacacgct ggagaaggat 652261 gtgatcaaag agcatccgct gtcagatcca tttgcgtttt ggtatgaggg gaaggatgtc 652321 actattgagg cctataatgt tgatacgacg ggaaatgaga tccacataaa cgacagaaaa 652381 acgaaaaagg aatataccct taccttgcct ccgcttgtca caatgggggc cagtgatgag 652441 aactttattt atatcattca aagcatgtct atttacgtga ttgacagaaa aacagaggaa 652501 atgattgaga ccctgagctt agcctcatac gctgatcaat tcgcagactc ggaggaattt 652561 atcgtcgcga gctcggatca taaattgact gtgattgaaa aagggacatg gaagacgaca 652621 tatattgcgt atcctgaaga tcttgaatat gcagatactg tgtactatga caaagaaagc 652681 ggcagttttt acgtggcgta cgaggacaaa gagggtggag cgaacttgct ggaatatggg 652741 gaggattttt ctattcacac atacagcttg aaattccctt atatggaggc gaagtttaag 652801 gggaatctat tgtatatagt tgcccaggaa gagcataaaa agggcatcgg cggatacgtg 652861 ggtgtgtttg atatccattc taaggagatg ctttatcagt ttgatttgcc tgaggaacag 652921 gtgaaggttc aggattttgt tgtggttgac aataagtgaa tactatatga aatagaatga 652981 caaagaccct tgcataaagg gttctttttt atgaaaaaaa caaattgaca ggatgaaaaa 653041 acaatttctt ccttctatat tgttttcaaa atttgggatt gatagaatat gacatatctc 653101 atagagaagg agggaagccg ttgagtcaag ccataccgtc ttcgcgtgtt ggtgttaaga 653161 ttaatgaatg gtataaaatg attcgccagt tcagtgttcc ggatgctgag attctgaaag 653221 cggaggttga gcaggacatt cagcagatgg aagaagatca ggatttactg atctattatt 653281 ctctgatgtg ttttcggcac cagctgatgc ttgattattt ggagccggga aaaacatacg 653341 ggaatcgccc tacagtgaca gagcttcttg aaacgatcga gacccctcag aaaaaactca 653401 caggtctttt gaaatactac tctttgtttt tccgcggcat gtatgaattt gaccaaaaag 653461 aatatgtgga agcgatcgga tattatcgcg aggcggagaa agaactgccg tttgtgtcag 653521 atgatattga gaaagcggaa ttccatttta aagtggcaga agcgtattat cacatgaagc 653581 aaacccatgt gtcgatgtat catattcttc aagccttgga catttatcaa aaccatcctc 653641 tatacagcat tagaacgata caaagcttgt ttgtgatcgc cggcaactat gatgatttca 653701 aacattatga taaagcgctc ccgcatttag aggcggcgct ggaattggca atggacattc 653761 aaaatgacag gtttatcgcc atttctctat tgaacattgc aaacagctat gacagatcag 653821 gagacgatca gatggctgta gaacatttcc aaaaagcggc gaaagtaagc agagagaaag 653881 tgcctgatct gcttccgaaa gtcttgtttg gattaagctg gacattatgt aaagcgggcc 653941 aaacacagaa ggcgtttcag ttcatagagg aaggattaga ccatatcaca gcacgttctc 654001 acaaatttta taaagaattg tttctgttct tgcaggccgt gtacaaggag actgttgatg 654061 aacgaaaaat tcatgatctt ttaagctatt tcgaaaaaaa gaacctgcac gcttacattg 654121 aagcatgtgc ccggagtgct gccgctgttt ttgaaagcag ctgtcacttt gaacaagcag 654181 ctgcgtttta tcggaaagtg ctgaaagccc aagaagatat tctaaaagga gagtgtttat 654241 atgcctatta agaaaaaagt gatgatgtgt ctggctgtta ctctagtttt cggaagcatg 654301 tcgtttccaa ccctgacaaa ctccggtgga tttaaggaat cgacagatcg aaatacgacg 654361 tatatcgatc attcccctta caaacttagt gatcagaaga aagcccttag ctagggcttt 654421 ttcttgcttt acggaagacg ttccattttc cacatcgcgg cattccttct atttctaacg 654481 caagacactc gaaacaacca aaccatttga ggtataatgg ataaagtgaa taacagtatt 654541 tagattgata tatatgaaag agagtggaac atcatgggcc gtaagtggaa caatattaaa 654601 gagaagaagg cgtctaagga cgcaaatacg agtcggattt atgcgaagtt tggccgtgag 654661 atttatgtgg cggcgaaaca gggcgagcct gatccggaat ccaaccaggc gctgaaggtt 654721 gtgcttgaac gtgcgaagac ttacagcgtg ccgaaaaaca tcattgaacg tgcgatcgag 654781 aaggcgaagg gcggagcgga agagaattac gatgagcttc gttatgaggg cttcgggccg 654841 aacggatcaa tgattatcgt tgatgcgctg acgaataatg taaaccgtac ggcgccggaa 654901 gtgcgtgcgg cgttcgggaa aaacggcgga aacatgggtg tgagcggatc tgttgcttac 654961 atgtttgacg cgacggctgt aatcggtgtg gaaggcaaaa cggctgacga agcgcttgaa 655021 atcctgatgg aagcggatgt tgatgtacgt gacattttag aagaggatga cagcgcgatc 655081 gtgtatgccg agcctgatca attccatgcg gtgcaagagg cgtttaaaaa cgcgggtgtc 655141 gaggaattta cagtagcgga gctgacaatg cttgcgcaaa gtgaagtaac gcttccggat 655201 gatgcaaagg aacagtttga aaaattgatt gatgcattag aagatttgga agatgttcag 655261 caggtatatc ataacgttga tttaggtgag taaggagtga gcaggctgtt atggcctgct 655321 ttttttgtcc cggaaattgt tttagctgta tgtaggcggc cgcctatacg atctataaga 655381 tattctcata ctctggactg taacctatgt gaaggagaga gtaaatatga ctgatacaag 655441 acatatgtat ggcggacctg gttttggtca ttatcagggc tttggtattg gccacccggg 655501 ctatggcatg caaagcacag gctatccggg ctatggcatg tatggaggcc acccgggcta 655561 tggcatgcaa ggctacccag atcacggcat acatggagga gtcggcggct atccgggata 655621 tggtgggtac ggcggttacc caagcggcgg ctatggaggc tctccgggaa ctggaagcta 655681 tccgagcatg caccatgaaa atgatggcca tcaccactat tatcaccatc atcatgatgg 655741 aaaagataat cttcatcacc atcatcacca tgttggaaag gataatcatc accaccatca 655801 tgatggtcat tatggccacc atcatcacca tatgggccac tggggaaaag acggttataa 655861 ataaagaaga tgatgataaa aagaggacac tcttgcagat caagagtgtt tttttagctt 655921 ttttcttgac tgttcagtct ggaaaatggt aacatttgtt tcaggaggtg atcatttttt 655981 ggggaggaat aaagaatttg atacggcgct tgttcttcac agggcgatag aggtttttgg 656041 agagtatggc tacgaaggaa cgtctcttca ggatctgctc tctcatttag gcattgcgcg 656101 ccaaagtttg tatgatacgt atggaacgaa gcgtgatttg tttttgtccg ctgtgaaatc 656161 gtatcttgaa gggaaaaacg ctgccgttat ggaaaggctt gaagcgccag gatctgtaaa 656221 ggaagccatt cgtgatattt ttcaggaggg tgtcaatgcc ctgagggatc cggaacgggc 656281 gaaggcgtgc tacattatta acagcgcgat tgaacagatc ccgcatgacc ctgagcttgc 656341 ccggtatttt gaaagacaat ccaagcagct tgaggacgct ttttatcacg ggcttttaag 656401 agcgaaggat caaggagaat tgaatggcga agatactgat atatctgcgc ttgctcggta 656461 cctgaatcag agcaggctgt cactgacatt tattgcaaaa gtgacggcag atatggatcg 656521 gcttcaggac catgttgacg tgagtttatc agtgcttgat taacatgtgg taaaggattc 656581 tttgcccatg tatgtacttt ttggactgaa tagtctagaa ataaaaatga ggtgatgatg 656641 aatgttgatg aatgagtttg aaaaagcatg tgaaacattg agaaagttta tggcttatat 656701 gcttgagaag gacatgaaga gctggacgga gctttgggat gagaatgctg tatttgagtt 656761 tccttatgcg ccggagggat caccaaaaag aatagaagga aaagcggcca tttacgatta 656821 tattaaagat tatcctaagc agattcatct ttcttcattt accgctccga cagtgtaccg 656881 ttcagcagac tcgaatacgg tgattgcgga gtttcaatgt gacggccatg tgattgagac 656941 tggactgcct tatcgccaaa gctatatcag tgtcatcgaa acgagagacg gccgcattgt 657001 gcgttatagg gattattgga atccgcttgt tgtaaaagag gcctttggag gatcattttt 657061 gcaaacagag gagagtggga aatgatgaaa cagaatccga ttttaatcac gggcgggacc 657121 ggcacagtcg gcagccgaat cgccagccgt ttaataaagc tgggatacag agtgcgtatt 657181 gcaagccgga aaaagggcgc gcttgctgat gctgagtatg tgtattttaa ttggaagtac 657241 gcctccagtt ttacgcctgc tctggaacag gtaaaacaga tctatcttgt tgctccggtc 657301 ggtgtatttg atccggctcc ctatgtgctt ccctttttaa aggaagcaaa gcgtctcggc 657361 gcaaagcggg tagtgatgca aagtgcgtct gttgtctccg agaacggtcc cgtgtttggc 657421 gcgcttcacc aggcagtgcg cgagtttcca gaatggacgg tgctgcggcc ctcatacttt 657481 atgcaaaatt tcatcaatgt ccagcaccgc atgtctattc aaacggaggg gcgcatcaca 657541 acggcttcgg gtgaaggaaa acttgggttt attgacgctg atgacatcgc agaaacagcc 657601 gtcagggctt tgattgatga tgttcctcat caaacacatc atattctgac aggtcccgag 657661 gcgctgagct atgccgaagc ggcggagatc attggagctg cggcgggacg ccgggtggag 657721 catgtcagca tttctcgttc cgagctgcag cataaaatgg aggcaggagg tttgcccgcg 657781 gattatgccc attttatggc gaagcttgat gaggcaatta gccatggtgc ggaacatcgg 657841 gtaacggata cagtgaagcg tgtgacggga aaagaacctc gttcgctgtc agagtttgcg 657901 gctgctcatg ctgcatattg gacctcattt tggactgaat agtctagaaa gaccttcggc 657961 gcttccgaag gtcttcttat tgaaaaagct aagtcgtgtt ttagtcataa tcatgcctcc 658021 tgcctcatac ctattaaggt cattgttttt gagaaaggag gagccggaat gaaggatatg 658081 cagccgttta cgcctgtcaa atcatatacg ccctttcaca gccgttttga tccctgtccg 658141 cccataggga agaaatatta cagaacgccc cctaaccttt atatgacctt tcagcctgag 658201 cacatggagc agttttcgcc gatggaggct ttgaggaaag gcaccctttg gaaggatctc 658261 tatgattttt atgaaaaccc ttatcgaggg ggagacgcac atggcaaaaa aggttgacgc 658321 cgaatattat cgtcagctag agcaaataca ggctgctgat tttgtgcttg ttgagctgag 658381 tctttattta aatacacatc ctcatgatga agatgcgttg aagcaattca atcaatattc 658441 cggctattca aggcacttaa aaagacagtt cgaatcctct tacggaccgc ttctgcagtt 658501 cggcaacagc cccgcgggca aggattggga ttggggaaaa gggccatggc cgtggcaagt 658561 ataaggagga atgcctgaat gtgggtgtat gaaaagaagc tgcaataccc tgtcaaggtc 658621 agtacgtgca acccgacgct ggcgaagtat ttgattgagc agtatggcgg agcggacggc 658681 gagctggccg cggctctccg gtatttgaac cagcgttata cgattcctga taaggtcatc 658741 ggccttttaa cagatatcgg cacggaggag tttgcccatt tggaaatgat tgcgaccatg 658801 gtctataagt taacgaaaga cgccacaccg gagcagctgc gtgaagctgg gcttggcgat 658861 cattacgtca atcacgacag cgcgcttttt tatcataatg cggcgggcgt gccgtttacc 658921 gcgagctata tccaagcgaa gggcgatccg attgccgatt tatacgaaga tattgccgca 658981 gaagaaaagg cgcgggcgac gtatcaatgg ctgattgata tttcggatga tcctgattta 659041 aacgattccc tgcgtttttt gcgtgagcgt gaaatcgtac actctatgcg cttcagagaa 659101 gcggttgaaa ttttaaaaga agaacgggat aaaaagaaga ttttctaata ggcagattgg 659161 cctctctttc atacaccctt ttacatacag agaaaatggt ctgtttttgc agtttggtct 659221 gcattataat caaggtgtgt gtgcaagctt actttttgat tgggaggcct ttatgacagc 659281 ttttaagatt gagaacgaaa cgattgcaga tggattttac gcgtgtccgg ccgtctatga 659341 ggatgcagaa tcgattaccg ggttgctcgt ccgaacagct gaatggctcc gggatcgggg 659401 ttctaaccaa tggagcggac ttctcaaagg gcaagatata catgatatca cggggtcaat 659461 tgaaaaggga catgtgtttg tgtttaaaaa agatgaagag cttgcggctg tcgtgatgct 659521 gctgcctgca ccgagcgagt gggaccggac gctttgggga gacgatgggc atgaggagtc 659581 catttattta caccgcctcg cagtaagccg ccggtttgcg ggacaggggc ttggagcccg 659641 cgtccttcag tgggcggaga cgggcataca ctttccggaa aaaacgcgga tccggcttga 659701 ctgtgtcgct gatagtgacg ccctgcattc cttttatcgg cgtatgggat atgaattcat 659761 gggtgctgat gcgtccggat atcatttgtt tgagaaagag attacggcag aataagcgtc 659821 ctttgcaggg ggcttttttg tctttttcta aaagggaggc aggcgatgtg tggtcaatat 659881 tatttgtgac agggattgtg acggcttgtc tgtttgctgg cgtatccgta ttgatgcgga 659941 tgagatttcc tgacaaaagt cggccggaat ggatgttggc cgggctgatc gtccttggtg 660001 tgtttgcgat ctggtacagc ctcgtgtatg tacgcggctg ggaaggggct gcgctcggaa 660061 tgcttggatt caatgtcatt ttcggagcca ttgccggata tttgatcgat aaggccatcc 660121 ggcgttacag gaaaagataa ggctgctgcc gtctctcaac aggtcgaaat tttcacagac 660181 cggcaggaat tttctttcga aaggagaaat acatattact ttaaaatgaa agcgttttcc 660241 aaagcaggaa ggtgatgttg atgatacaca gtgtggcaaa tgggctgaat catttttgta 660301 cgtgggtgat gagactggcc tatttgaatg tgctttggat tttgttttct cttgcaggcc 660361 tggttgtatt tgggctgatg cccgctactg ccgcgatgtt tacagtggcg agagaatggg 660421 cgaaggggaa tacagatgcc ccggtgtttt ctgtcttttt tcggacgttt aaaaaggaat 660481 ggcgggcatc acagatcctc gggcttatcg ttgtgacggc tgccctgttt ctgtttgcgg 660541 atatgcggat agcggctcag atggaccagc ctgtgctcgt caatgtattc gtgagcatta 660601 gtttgatttt cgcgtttgtt gtgctgtatg tgttcccggt attttctcat tttgacgtaa 660661 aaatcagaga ggtgctgagc atcagctttt tcattgcctt cagtcgtccg gcggtgacgc 660721 ttttgatggc agcgggcgct gtcggtgtgc tttgtctcgt tctgtttcat gtcacgtttc 660781 tattgttttt cagcgggagt ttactcagcc tgatcttaac gaagctgtcc tttaaagcgt 660841 ttcggtcaat ggatcagcgg caggagaaag aaaaggcggc atgaagaaaa gagttgctgg 660901 ctggtacagg cggatgaaga ttaaggataa gctgtttgtg tttctatcgt tgattatggc 660961 cgtatccttt ctgtttgtat acagcggggt ccagtatgcc tttcatgtgt atgatgagca 661021 gatttaccgc aagtcctcgg aggtgcttcg gatgtcttct gaaaggatcg aagacgagct 661081 gaagaagata gaggatgtgt catatgaaat cattacagac gaacagattc agcgcatcct 661141 gagcatgcaa aatcgggatg atacgtatga tcaatatcaa atgaagcagg agctgtggga 661201 tcagcttgcg ggatatgcca gcgatgaaaa gtacatcgat tccattcatg tgattgatgc 661261 ccgcggctca gagtattcag ccggaagcag ttcttcagat cttttgcagc aggagcagga 661321 agaggtattt aagcgagcga aagcgaaaag tggaagaaat ctttggatga cgctcggcgg 661381 gtcagacccc gtcctgattt cagcacggca gatcaggtcc tatcaccagc tgagtctgaa 661441 cggcttgggc atggtactga tccaggtcaa tgtaaaacag atgattcgtg atgtgccgaa 661501 ggattggggc gattcagtcg gagacattat gattgctgac caaggcggta atttggtgta 661561 tacggcacat gcatcagcgc atgttcctga ggcagcaaaa gagacgttga agcaccccgg 661621 ttatgacttg ataaaaaaga atggcaaacg ttactttatt tcttatcttc aatcatccta 661681 ccaaaattgg agctactata acgttatccc ctttgatcag atgttcgcaa aaatttcctt 661741 tatgaaaaca gtgatcggca catgctttct tctctttttc tgtgtggttt tgcttttcgg 661801 aaggaaaatc gccaacagca tcacggagcc gattgaacag cttgtgaccg cgatgaaatc 661861 ggtacagcac agcggcattg aagcaggtgt gtcgctttct ctgccggaac atacacagga 661921 tgaggccggc atgctgaacc gccattttac tgtcatgatg aaacggatta atgagctgat 661981 ggaagaaaat gtggaaaaac agctcatcat taaagaaacc gaattgaaag cactgcaagc 662041 ccagatcaat ccgcattttt tatataacac gctcgagtcc atcaattggc tggccaaggc 662101 gaatcagcaa aagcaaatct caaaaatggt ggaatcgctc ggttttcttc tgcgaaacag 662161 catacatatg aagaaggata tcgtgaccat tcaggaggag gcggacattg tacgtcacta 662221 tatgaccatt cagcgatttc gatttgaaga gcgcctgaaa ttcacgttgg atattgacga 662281 tgaggtgaag cattgcctca ttccgaaact gacgctccag ccgcttgcgg aaaatgcgat 662341 tcaatacgcg cttgaaccct ttacaaggcc atgcgccatc cggattcagg cgaaaaaggc 662401 gaagggctgt gtctgtatta cggtcgaaga taacggccct ggcatggatg gacggattct 662461 tgaatcaacg ggtggaagag gaatcggact ttggaatatt cgcgagcgca tcagcctgac 662521 attcggagag ccatacggat tgcggattca tagtgagcat gaaaagggga cgaggattgt 662581 gatcacaata ccgtgccgaa atgaggtggt gtgatgtata aaatactgct ggctgatgat 662641 gagaggatta tccttgatgg aatggcggga atcattgagt gggagtcgct tggcgcctca 662701 ttgatcggaa aagcgcagaa cggacatgaa gcatatgaaa agattgtaca taagcagccg 662761 catatcgtca tcacagacgt caaaatgccc ggcatggacg ggcttgagct gatcaaaaag 662821 gtgtcagccg tcagcccgtc ggtgcaattt atcgtcctgt ccgggtttgg agagtttgag 662881 tacgcaaagg aagccatgaa atatggggtg aagcattatt tgctgaaacc ctgcaatgaa 662941 cagcagatta tcagctcgct ggaggaaatc attgctgagc tgaagcggca agatgtgcac 663001 aaaaagaaaa cagcccatct gaaacacgag ctggaccata tccgttcctt tgcagccgat 663061 caatacttgg aaggcttgat cgccggtgtg gcccagcttt ctccgccgcc ttcacttgcc 663121 ggaaaaaaga tccgcctctt gatcttaaaa ggggaacaat ctattgatgc tgcagccaga 663181 gaggcactcg gatcggcact gacagcggtt tgcagcagcg gtgaatggac cgtgctcgcc 663241 gtagaggaga acgccgctga aaaggtggcg gaggtttttg cggaccgcaa gatggccatc 663301 agtcaggcgg gagaactccg gcacgcgggg cagctgtttc gtgacacagc tgaagcgtct 663361 ggtgacctgc atgggagcgc agtgatttca aaaatgatca ggcttattgc cgacgagctc 663421 ggaaatccga atctgtcctt aaaatgggcg gcgaaggata tgctgtttat gaatcctgat 663481 tatctcggga agttatttaa gcaggaaaca ggcgagaaat tttcccaata tgttacacgg 663541 gtgcgtcttg agcatgcgat gaagcagatg aaaataagga gggacgtgag cgtttcagaa 663601 attgctgaag aaatcgggtt tggcgataat ccgaagtatt tcagtcttgt ttttaaaaaa 663661 tataccggtc tgacaccgtc agaattcaga agaaaacagg gaggcgcttc cgcaggatag 663721 ccatctctgt ttttttgact ttcgccactg ttttttgagt gtttcgccct atccgaacgc 663781 tttaaaataa aatgtaagca cttacattaa aggggggatt ggtttgaaga agatttgtta 663841 cgtgctgtta tcccttgtct gcgtcttttt gttcagcgga tgttcagcgg gtgaagaggc 663901 ctcgggaaaa aaagaagatg ttacactcag aatcgcgtgg tggggcgggc agccaaggca 663961 tgattataca actaaggtaa ttgaactata cgagaaaaag aatccgcacg tccatattga 664021 agcggaattt gcgaactggg atgactactg gaaaaagctt gcgcccatgt ctgccgccgg 664081 ccagcttcct gatgtcattc aaatggatac cgcttactta gcccaatacg gaaagaagaa 664141 ccagctggaa gatttaacgc cgtatacaaa ggatggaacg attgacgtca gttcaatcga 664201 cgagaatatg ctgtcgggcg gaaaaatcga caataagctt tatggattta cgctaggtgt 664261 caacgtgctg tctgtgattg ccaatgaaga tttgctgaaa aaagccggtg tgtctatcaa 664321 tcaggaaaac tggacgtggg aggattacga gaagctggcg tatgatcttc aggaaaaagc 664381 cggtgtctac ggttccaacg gaatgcatcc gcctgatatt ttcttccctt attatttgcg 664441 cacaaagggt gagcgctttt ataaagaaga cggcactggc ctcgcgtatc aagatgatca 664501 gctgtttgtc gattactttg aacggcagct gaggctagtg aaagcgaaaa cgtccccaac 664561 acctgatgaa agcgcacaga ttaaagggat ggaagacgat tttatcgtca aaggcaaatc 664621 agcgattaca tggaactact ccaatcaata tttgggcttt gcccggctga cagactcgcc 664681 gctgtctctc tatctgccgc cggagcaaat gcaggaaaag gcgctgacac tgaagcccag 664741 tatgctgttt tccattccga aaagctctga gcataaaaaa gaggcagcga aatttattaa 664801 tttcttcgtg aataatgagg aagcgaacca gctgattaaa ggcgagcgag gcgttccagt 664861 ctccgacaag gtggcggatg cgattaaacc gaagctgaat gaggaagaaa ccaacatcgt 664921 ggagtatgta gaaaccgcgt caaaaaacat cagcaaagcc gatccgccag agcctgtggg 664981 aagcgcggag gtcatcaagc tgctgaaaga tacgtcagat cagattctgt atcagaaggt 665041 atcgccggaa aaagccgcca aaacgttccg gaaaaaggcc aatgagatat tagagaggaa 665101 taattgacgg gaaatggggc tgacgcaatg aaaaaaagcc ggagtataag aaaagacaat 665161 ctggcgggat atgcttttat ttctccgttt atcatcgggt tcctatgctt tacggtgatt 665221 ccgatggggg cgtccctgtt tctgtccttc acgagctatg acttgtttac ggcgccgaaa 665281 tggatcgggc tcgacaactt taaggaaatg tttacgggtg acgaaaagta ttggcagtct 665341 ctgaaggtga cgtttacgta tgtgcttgcc ggggttccgc tccgcctcgg cttcgcgctt 665401 tttatcgctg tcattttaaa caatgcagca aaaggaacgg ccatttacag aacgctcttt 665461 tatctgcctt cgatcatcgg cgggagcgtc gccgtggcga ttatgtggcg caatattttt 665521 ggcaatgacg gggtcatcaa tgcgctgctg ttttttgtcg ggattgatca aaaaattctt 665581 tggtaccaga atccgacaag tgcgctgtgg acattgattc tgctgtccgt ctggcagttc 665641 gggtcgtcaa tgctgatttt tttggccggg ctgaaaaaca ttccgtcttc gtatttggaa 665701 gcggcaagtg tggatggggc aaatcgggtg cagcgtttct tcaagatcac gcttccgatc 665761 cttacaccga ttattttctt taacctagtg atgcagacga tttctgcttt tatgacattt 665821 acacctgcct atatcatttc gaagggcgag ggcgggccgc ttgacgggac acttctctat 665881 tcgctctatt tgttccagcg tgcgtttaac tattttcaaa tgggctacgc atcggcgatg 665941 gcgtgggtca tgcttgtcat tgtcgggctg attacgctca tattgtttaa aacatcgtca 666001 tattgggttc attacgagtc aaaggaggaa tgacggatgg agccggtcaa ccagcctgtc 666061 agagaagccc cggtttttga gagaaaaaaa gccgggcgcg tcagtcccaa acgcatactg 666121 ttccatgttt ttacggcaac gctggcggtg ttgctgctgt acccggttat ttggctgttt 666181 gtcagctcgt ttaaagaaag cgccagtatt tttacaacct cacattctct cattccagac 666241 ccttttattc tcagtaacta tgctgaaggg tggaagggca ttgcgggaca gccgtttctg 666301 acgtttatta aaaactcggc gattattgtc gggctgtcaa caatcggtgc cgtcatgtca 666361 tcggctgtca ttgcgtacgg atttgcgcgt ataccgttta agggaaaaaa attttggttt 666421 gcgtgcatga tggggacgtt aatgctgcct catgaagtgt tgatgattcc gcagtatatt 666481 atgtttgcga aattagactg gctgaattcc tttaaaccaa ttgtcgttcc gcaatttttc 666541 gggcatgcgt tttttatctt tctgatgatc cagtttatcc ggacgattcc cgaggagctg 666601 gatgaagccg cgcgaatcga cggatgcgga cgctttgcct gcttttggcg gatcattctc 666661 ccgctgattg cccccgcgct tgcgacgtct gcgattttct ccttctattg gaagtgggag 666721 gagctgattc agccgctctt gtatttgaat aagccggagc tttaccctgt ttcacttgcg 666781 ctgaagcttt ttctcgatac agagtcggct tcgaactggg gcgcgatgtt tgccatgtca 666841 gccgtctcgt tattgcctgt gattcttgtt ttctttttgt ttcagaaata tatcgttcag 666901 ggcatcagta cgaccggatt aaaataaaaa ggagtgttgc agatggcaca gcttatcttt 666961 gatgaagaaa aggtgacgtc ggttattgac cggatcgtga aacggacatt tcagatggat 667021 tttgcgtggg attggccggg cggcgttgcg ttttacggtg tggcggaggc ctatgaagcg 667081 acggaaaacg aggaatatat caatctgtta aaaacgtggg tggatgaaca gctggaggat 667141 gggctgccgc cgctttcgat caacggagtt tccattgggc atacgctttt gttcctccac 667201 aaggtgacag gtgatgacgt gtatttggaa acagcggccg agatggcgga atatgtgctg 667261 cataaggcgc cgcgctttgg cgagggtatc cttcagcata cggtgaatgc ggcagaatac 667321 gtattccctg aacaggcatg ggcggatacg ctgatgatgg ctgggctgtt tatgctgaga 667381 atcgggcggg tcatggagcg tgaggattat tttgaagacg gcctgcgcca gtttcacgga 667441 catgaggatg tgcttcagga ccctgtcacg aatttgtact accacgcctg ggacaacaaa 667501 gcgcaaaatc atctgtcggg gatttattgg ggcagggcga acggctgggc ggcactcacg 667561 atggcaaagg cgctcccgct tattgaggtg acacatcctt cctttatgat catcgacgga 667621 tcgctcagag accagctgag cgcgcttgtc cggcttcagg atgaatcagg gctgtggcat 667681 acaattttgg atgatccgga ttcttatctg gaggtttcgg catcagcggg tattgcttct 667741 gctctgatgt cgagcggaaa gctgtataca aaatatgtgc agaaatcgct tgccgccatt 667801 ttggatgcag tggaagagga cggacgggtc agcagggtat cggccgggac agccgtcatg 667861 aaaaatgccg aaggatacaa acaggtgcct tacaaacgaa tacaaggatg ggggcaggga 667921 cttgcgctga cgtttcttgc tgatgttttg aaaacgaaaa aacgcttgta tcagtaaaga 667981 tagcggcggg gggagaggga tgaaaaaaca gcctcaacag aaggaacggg tttctcgctg 668041 gaagggaacg tatttcaaaa gaaactttgt cttcattttg ctgattgcct gtattcccgg 668101 attgctgact ggcggcgcaa tctactttct ttcgatcgac aaggtggaga aagagctgca 668161 gagatcgcat gaaacacagg tggcgcgtga ggtcagccga atggatgaga agctgggagt 668221 gcttgaactg gcactcaccc agatggccta cgattcttca ctgatgaacg gattggccga 668281 gagggatttg gagaaagact ttacgttctc ctatcaatta acgaaaaagc tgtttctttt 668341 gcgggatcag cagccgctga tcgagcaggc ttccatcttt ctgaacagcc cccggccact 668401 tgtgctgagc cctgaataca gcgctttgac agaacaggag gcgcttcgca agtatcgctc 668461 gctgcttgcc tcagaccaca gcatttattg gaaacggtcg ggaaaccaag cgatgctgat 668521 ccagctcatt ccgggcgcgg cggagaaacc gttcggcgcg atcatgctgg cggttgatcc 668581 gaaagaaatg gaatcaatcc tgcaaagctt gtccccctat cctgatggca gtgcgttgct 668641 tttagatcaa aatcgagagg tgctgtttca tgagggggaa aaagattttg aaaagacttt 668701 acttcatgag ataaaaaaac agcctgctga gaacggccat tttcagatgg aatggaaagg 668761 caaggtgtat tctgtctcct ttggagaaat gaaccggatg catcagcaat ggacctttgt 668821 gtcagcggcg cctctttcag ctattacagc gccgatggtg tttttatcaa aagtgatcat 668881 cgtgatgctg gtcatttgca tcggtttggc ggtgtgcatg acatggtatg catcaaaaaa 668941 aatctatcgt cccatccagc atttgcttgg cttgtttacc ggaggagaga agaaaacatg 669001 gcaggcgtcc gggcaggatg aattcaaatg gattgaaaag agatggcagg atctatccct 669061 tgaaagccgg aagctccaac agcagctcct gcggcagacg ccccatatga aaaagagttt 669121 tttgcagcat ctcttacaga gcgattttta ctatgacaac gaggaaagcc tcagatttcg 669181 gatggaggag gctggctgga acatcggcgg aaacgtgttt catgtgcttg atctacaggt 669241 gacagggctc cgctgtgaaa aaagcatctt ccgtgaaggt gatgaacagc ttgccgtgtt 669301 tacactgact aatatcgctg aggaattggc ggctaaacgc gtttttcagc tctccatact 669361 tgatatcggc cggctttctg tcaccgttct tgtgatgaaa acaaacagct ctgatctgaa 669421 ggcgtatata acggagctgg cacgccaatt tggagatgta accggactat gcctgacctc 669481 gacattgagc agcaagacgg agcgtgtcac ggaaattcct tctttatttc aggatgtgaa 669541 atgcggcaaa tcccgcagga agtttgctaa ccgggatcag gtcattgatt tgcaggccga 669601 cttccctcgg gatgagcagt tcgctcctta ttaccctttt gagctggaaa aacaaattgt 669661 tcagaccatc cggctggaaa gaaaacagga agccaaggaa ctgatagatg gatgtatgaa 669721 ggaactgtcg gaaaaagcgg ccatagacag gcatgtgcat tccgccctga ttcagctgtt 669781 ttcccgcatt caggaggata ttttgcattc cgggctcaat cccagcgaac tgtttcagca 669841 ccggaatccg tttcttgata tttcagaatt gcgcgaacct aacgaagcgg cggcctggct 669901 gatggatgta gtggtgacgc cttacctttc caagcttgag ggcagaaaaa acagacagca 669961 aaagcagctg gcagaacgtg tgattgcgat gattcacgaa cagtatatgg cggacatttc 670021 attggaaagc tgtgccgatg cgcttggcat gaattcctat acgttaagca aggcatttaa 670081 gcaagtgacc ggcattaatt ttatcgatta tgtgacccag atcagaatcg aaaaggcgaa 670141 agaactgctg gtcaatacga ataaaaaaat tcatgatgtg tctgaagaag tcggctatcg 670201 ccacaattat ttcaatcgga tttttaaaaa acaggtcggc atgccgccgg gtgtcttcag 670261 gcaaatgtat caggaaacgc cgtgaaagga gagaacatgt gatgaagaaa ccgattcaag 670321 tatttttagc gggggattcc actgtgagtg actgcccgcc tcatgaagcg ccgatggcgg 670381 ggtgggggca ggtattcggg caattgtttt ctgaaggtgt gctggtccgc aatcatgcca 670441 aaggaggagc gagcaccaat tcttttgtgg aggaaggaag gcttcaagca attgccgagc 670501 acatcacaca aggcgattat ttgttgattc aattcggcca caatgaccaa aaaccgcggg 670561 ggacgaagcc gtactccaca tttcagcagt ttcttacctt gtttgcagat acggcacgcg 670621 aaaagggcgc gcatcctgtg ttcgtcacat cggtgcagcg ccgccgcttt gatgaaaacg 670681 gacggatcga gcatacgctc ggtgagtatc ccgatgcgat gaaagcactg gcgaaggagc 670741 tcgatgtacc tgtgattgat ctgcttgcga aaacaaaggt gctgtatgaa gcatacgggc 670801 cggaggagtc gaagcgattg ttcgtttggt ttcagccgaa tgaacatccg aattacccgg 670861 acggcattga ggacaatacg catttttcgg aaaaaggtgc aatggaggtt gcgaagcttg 670921 tggcagaagg cattgaagag ctcggacttc cgcttaagga ccaccttgtg agccgggagg 670981 gaaaagaaca tgtataagga aggcgcttgc ttgtaccgca atccgctccg gtctaaaagc 671041 gatgtgaagg attggcggat ggagggaggc ggacagatct catttgacga tcacagcttg 671101 cacctgtcac atgtccagga tgaagcgcac tttgtctttt ggtgtccgga aacctttcca 671161 gacggcatca ttgtgacatg ggacttctct ccgatcgagc agcctggact gtgtatgctg 671221 ttttttgccg ctgcgggtat tcgcggcgag gatttgtttg acccaagtct caggaaaaga 671281 acaggaacat accctgagta tcattcagga gatatcaatg ccctccacct gtcgtatttc 671341 cgcagaaaat acgcggagga aagagcgttc cgcacctgca atttaagaaa aagccgcggt 671401 ttccatctcg ccgcaatggg ggccgatccg ctgccttctc cagacgacgc tgattctccg 671461 tatcgtatga agctgatcaa agacaaaggc tatgtgcact tttcaatcaa tggtctgccc 671521 attcttgagt ggatggacga cggcagcaca tatgggcctg tgttaacaaa aggaaaaatc 671581 gggttccggc agatggcccc catgaaagcc gtttacaggg attttgccgt gcatcaagcg 671641 gtgagaagat gaagacgact gtaacggatg cgctttatgc aggctgcgaa gcggtggtga 671701 aaatagcatg gctcaacggg ctgtggctgt tgtttacact tttgggcggc gttcttttcg 671761 gatgggcgcc gagcacagct gcgatgtgtg ccgttataag gaaatggctg atggggcaaa 671821 aggatgtccc gatattttcg ttatttctcg atacctataa aaaagagttt ctcaaggtta 671881 atgcgatcgg attggcgttt tcggctcttt tgctcatatt gtctgccaac tatcattatt 671941 tttctgccag tacgaattgg ctgtcctttg ccgtaacaag ctgcacgctg cttgcagggc 672001 ttttgtatat catcgcgctg atgtatgtgt ttccccttta tgtgcattac cagctcccgc 672061 ttcgcaaata tattccgcag gcactgctgt ttggcgccat gagaccgctg acaactggct 672121 gtatgctgat cgggtgcgga tttgtccttt atttgctgta tacgcttcct ggcctgatcc 672181 cattttacgg cccgtgttta tttgggcttg tgttgatgtt ttttgctctt aggggatttc 672241 aaaagacgga ggcccagcac catcaagccg ggtaacaaaa aaatgacaaa taagcaaaaa 672301 agtgcagtgt ccgaaatagg cagatgcaaa aaagtgaaat tgaagacagc tcacaaagcg 672361 cataaaatcc aatttaagta agcgcttaca gataaatgag aaggagctgt ctgatgatta 672421 gacgaaggaa acgcatgttt accgctgtta cgttgctggt cttgttggtg atgggaacct 672481 ctgtatgtcc tgtgaaagct gaaggggcag cgcggcagat ggaagcgctg aaccgggggc 672541 ttgtagcggt caagacggac gggggcattt ttgtcagctg gcggtttctt ggaaccgaaa 672601 acgcatctgt tttgttcaat gtgtacagag acgggcaaaa actgaatgct gcgcctgtca 672661 aaacaacgaa ctatgtggat aaaaacggtt cggcgggctc aacgtatacg gttcgggctg 672721 ttgtaaacgg taccgaacag ccggcttctg aaaaagcctc cgtatgggcg cagccgtatc 672781 attccgtccc gctggataaa ccggctggcg gcacgacgcc aaagggtgaa tcttacacgt 672841 acagcgctaa tgacgcaagt gttggcgatg tggatggtga cgggcaatac gagctgatcc 672901 tgaaatggga cccgtccaac tcaaaagaca attcacagga tggctatacg ggtgacgtgc 672961 tgattgacgc gtataaactg gacggcacaa agttatggcg gatcaatctc ggcaaaaaca 673021 tcagagcggg cgcgcactac acccagttta tggtgtatga ccttgatggt gacggaaaag 673081 cagaagtggc aatgaaaacg gcagacggga caaaagacgg cacgggcaaa gtaattggaa 673141 atgccaatgc agattacaga aatgaacagg ggcgtgtgct ttcaggccct gaatatctca 673201 ctgtgtttca aggttcaacc gggaaagagc ttgtcaccgc aaattttgaa ccggcgcgcg 673261 gcaatgtgtc ggattgggga gacagctacg gcaaccgtgt tgaccgtttt ctcgccggca 673321 ttgcctacct tgatggacag cggccgagcc tgatcatgac cagagggtat tacgctaaaa 673381 ccatgctagt tgcctataac ttcagggacg gaaagctgtc aaagctttgg acgctggact 673441 cctcaaagtc aggaaatgaa gcgtttgccg gacaggggaa tcacaacctg agcatcgcgg 673501 acgttgacgg ggatggaaaa gatgagatta ttttcggctc aatggctgtt gatcatgacg 673561 ggaaaggcat gtactcgacc ggcttaggcc atggggatgc cctccataca ggagatcttg 673621 atccgggccg gccggggctt gaggtgtttc aagttcatga ggacaaaaat gcaaaatacg 673681 gcttatcttt ccgggatgct gcaactggaa aaatcctttg gggcgtttat gccggcaagg 673741 atgtaggccg gggaatggct gctgatattg acccgcgtta tccgggacag gaggtgtggg 673801 caaacggttc tctctactca gcgaaagggg tcaaaatcgg aagcggggtt ccgtcctcga 673861 ccaacttcgg catctggtgg gacggcgatc tgctccggga acagctggac agcaaccgaa 673921 ttgataagtg ggattatcaa aacggcgtat cgaaaaatat gctgactgca tcaggcgcag 673981 cggctaacaa cggcacaaaa gcaacaccaa cgcttcaggc tgatctgctc ggtgactggc 674041 gcgaggaagt ggtgtggaga acggaggaca gcagtgctct gcgcatttac acgacgacca 674101 ttccgactga gcacaggctg tatacgctga tgcacgatcc ggtgtaccgg cttggcatcg 674161 cctggcaaaa tatcgcctat aaccagccgc cgcacacaag cttcttttta ggagacggca 674221 tggcggaaca gccaaaacca aatatgtata cgccttaact gaaaggggga aggaacgggc 674281 tgcgcgcagc ccgttcccat caaatgaaac caaaaaagag gcaaatggaa tacctgacca 674341 gaggtttgat tgcggtacag acagaacagg gcgtgtttgt cagctggcgt tttctcggca 674401 cggatcatga gacgacggct tttcaccttt atcgggatgg aaagcggatc acccgcgatc 674461 caatcgctga aagcactaat tttctcgatc aaaacggaac ggctgactct gtttatcaag 674521 tggcggctgt caataaagga cgggaagaaa agctttccaa gaaagctcgt gtttggcagg 674581 aaaatgtcct ggaggttcct cttgccaaac cggaaggcgg tgtgacgccg gacggaaagc 674641 cgtacactta cagcgccaat gatgccagtg tcggggatat agacggggat ggagaatatg 674701 aaatgatcct gaagtgggac ccgtccaatt caaaagacaa cgctcatgac ggttataccg 674761 gggaggtgct catagatgcc tataaactgg acggcacctt tttgtggcgc atcaacctcg 674821 gcagaaacat cagagcgggt gctcattaca cgcaatttat ggtgtatgac cttgacggtg 674881 acggaaaagc agaaatcgcc atgaaaacag ctgacggcac aacagacggg aaaggacata 674941 tcatcggtga tgagcaggcc gattttagaa acgaacaggg cagaattttg tccggtccgg 675001 aatatttgac cgtgtttaaa ggagaaaccg gtgaggcgct cacgaccgtg gaatatgaac 675061 cgccccgcgg caagctggag gattggggag acggctatgg aaaccggatg gaccgttttc 675121 tcgccgggac cgcttatttg gatggggagc ggccgagcct tgttatggcg cgcggctact 675181 atacgagaac cgtgctcgtg gcatacgatt tcagaaacgg aaggctcaaa aaacgatggg 675241 tatttgactc caaccagccg ggacatgaag catacgcagg acaggggaac cacagcttga 675301 gcgtggcgga cgtcgacgga gacggaaagg atgaaatcat atacggcgca atggctgtcg 675361 atcatgacgg aaccggcctg tactcaacgg gcctcgggca cggagacgcg atgcatgtag 675421 gggatctgga cccgtcacga aaagggcttg aagtgttcca ggtgcatgag gacgccacga 675481 agccgtacgg actgtcgctg cgagatgccg gaaccggtga gatattatgg ggcgtccatg 675541 ctggaactga cgttggccgg ggcatggcgg ctcatattga tccaagctac aaaggatcgc 675601 tcgtctgggg aattgatccg ccgggcaatg atggcatgtc gtacgggctt ttcacgagca 675661 aaggcgaaaa aatcagcgac aaagcgccct cttcagccaa tttcgccatc tggtgggacg 675721 gtgatttggt cagagaactg cttgatcatg actgggacgg aacgatcggc aggccaaaga 675781 ttgaaaaatg ggatgctgaa aacggctgtc tgaagacgat atttcagccg gccggcgtgt 675841 tgtccaacaa cggcacgaaa ggaaacccgg ttcttcaggc caacctgttc ggagactggc 675901 gggaagaagt gatatggaga acggaagaca gcagcgcgct ccgtatctat acaacaacac 675961 atctcacccg ccactgcttt tacacgctga tgcatgatcc ggtttacagg ctcggcatcg 676021 cctggcagaa taccgcctac aaccagccgc cgcacacgag cttttacctc ggaacgggaa 676081 tgaaaaaacc gccgaagccc gccctgtaca tagcgggaag caaagcggag gcgccgctgt 676141 aggaggacta agggataaga cgcaaaggct gaacgctacg ccaagatgat tagagaactg 676201 gcaggacgaa ccaatgctca agcgctgtac gcaccggttt tttcaaggga agagctatcc 676261 gtgatggaag ctgtataaaa aacgaggagg aatgaaaaaa tggcaaatca tatttatctt 676321 gccggcgatt cgactgttca aacgtatgga gacagcacaa atcaaggggg ctgggggcag 676381 tttctcggct cgcatctgcc ggagcatatt caagtgatca acagagcgat cgggggaaga 676441 agctcgaaaa catttgtgga agagggcagg cttcaggcaa tcctcgatgt gattgagccg 676501 gatgattggc tgttcgtgca gatgggccat aatgacgcgt caaaaaataa gccggagcgc 676561 tacaccgagc cctatactac ttataaacaa tatttaaagc agtatatcgc aggcgcgcgg 676621 gaaaaaggcg cccatccgct tctcattacc cccgtagccc gctttcatta cgaaaacggc 676681 gtgtttttga acgattttcc tgattactgc attgccatga agcagacggc cgctgaggag 676741 aatgtccagc tcattgatct gatggagaaa agtctcgctt tctttactga gaagggcgag 676801 gaaaaagtgt acacctattt tatgatttca gaagggatta acgattacac gcattttaca 676861 aaaaaaggcg caaatgaaat ggcgaaactt gtggcaaaag gcataaagga gctcggcctg 676921 ccattgacag aatcgatcat caaagaaagg tgaaaatgtg atgagaaaac tgtatcatgg 676981 cgcttgctat tatccggaat tatgggatga agagacgatt cagcaggaca ttgacatcat 677041 gcgtgaagtt ggcgtaaatg ttgtgcggat cggcgaattt gcctggtcag tcatggaacc 677101 tgaagaagga aaaattgacg tcggtttttt caaagaaatc atcgcccggc tgtatgatag 677161 cgggatcgaa acgattatgt gcacgccgac gcctaccccg ccgatttggt tctcacatgg 677221 ccggcccgaa cgcatgcatg ccaatgaaaa aagagagatc atggggcatg gctcccgtca 677281 gcatgcctgt acgaacaacc cgtatttccg aaaaaaagcc gccatcatca ccacagccat 677341 cgccaaggag cttggccggc tcccggggct gatcggatgg cagctagaca atgagtttaa 677401 atgccatgtt gcagaatgca tgtgtgagac atgcttgcgc ctatggcatg actggctcaa 677461 aaatcgctac ggggtaattg agcgcttgaa tgaagcttgg ggaaccgatg tgtggagcga 677521 gacctatcag acgtttgagc aagtcccgca gccgggaccg gccccgtttc tgcatcatgc 677581 ctctctacgc actatgtatc agctgttttc gatggagatg atcgcttcgt ttgcggatga 677641 acaggccaaa atcatccgct gctattcaga tgcgccgatc acgcataacg gatcagtcat 677701 gttcagcgtg gacaatgagc gaatgtttca gaatctcgat tttgcctcct atgacacgta 677761 cgcttcgcag gaaaacgcct ctgccttttt attgaactgt gatttatgga gaaatctgaa 677821 acaagggcgc ccgttttgga ttttggaaac gagtccgtcg tatgccgcct cgcttgaaag 677881 ctccgcttac ccgcacgcag acgggtattt gcaggccgaa gccgtatcgt cctacgcctt 677941 agggagccag gggttttgct actggctatg gcgacagcag cgttcaggca gcgagatttc 678001 ccacggttcg gttctcagtg cctggggcga acccaccatc ggctatcaaa atgtgctggc 678061 ggttgagcgg gcaagaaagg aaatcgagcc tattattcta tcgactgaac ccgttcaagc 678121 cgaggcggcg atgacttact ctgacagagc aaaagcattt attaaaactg agcctcaccg 678181 gggactccgg catcgttcgc ttgtgacgca tttttatgaa cgtattctca acacggggat 678241 tcaccgtgac cttattccgg aaggcgctcc actggacggc tatcgcttgc tgtttacgcc 678301 atttgtgccg tatttgtctt ctgaatttat caaaaaagct tcggcattcg ctgaagcggg 678361 cggcatctgg atcaccgggc cgctgacagg aggacgcaca tgcgagcata ccattcatac 678421 cgattgcgga cttggcgaac ttgagaaaac gtcagggatc aaaacacttt ttacctttcc 678481 gatgaatgag aacgtgaata caggaaaagc gtttggcatc acggcgccgc tcggactgtg 678541 gagcgcggtg tttgacacag agagcggaaa cacccttggc acggttgaag caggaccggg 678601 ggcgggccat gcttttctga cggaacggaa ttacggcgag gggaaaattg tcatgctggg 678661 ctcgcttcca tccgggaaag aaggggatgc gatgctggaa gcgctcgtca ggcattatgc 678721 ggaggaagct gttatttcca gccggtcgga tgtgacaccc ggcacgatcg ttgccccgcg 678781 tataggcgaa aacggccttg tgtggatcgt tgtgaatatg gatggaaaag gcgggagcgt 678841 gacattgccg gaatcgggaa cggatttgtt gacgcaccgc ttggaaaagg cggggagact 678901 ggcggtcgga ccgcatgaat accgtgtgat tcaatttgac aatcacagct gattctttgt 678961 atcgaatcag cttttttcta tggagggaga gacagatgaa aaagatcaaa tggttatcag 679021 gacagccaaa ggtgacaagc ggcgtgacgt ggggcatgcc atggaaaaaa ggagaattaa 679081 aaaaaggaga ccgtctggcg cttatgaatg aaaacgcgga aacgcgatat gtgcaaagcg 679141 aaccgtcggc ctattggccg gacgggagca tcaagtggac gaagcacgcg gcggtgtttg 679201 gcggtcagga aaaccaaagc tttacagtgc acaaaagaga agtgccgcag ccaactgaat 679261 cgctcagcat tcttgagaca gagcatgata tccaagtgga tacaggagca ctcgtttgta 679321 ccattcataa aacaggatct gatttcattc aatcattgca gatcaatgga aagccgatcg 679381 ccgcaggcgg gaggctcgtt gcgataagag aaacgagaaa agagtcagcg gcgaaaatgg 679441 ttcttttgca tgaaaggtct gtcagcttta tcaaacgggc ggcgattgag cagagtggtc 679501 ctgtcaaagc agtagtcaaa atcgagggag tgcatgtgct tcataaaacg tatgaggaat 679561 ggctgccgtt tgtcatccga ttaacgtttt atgccgggct gtctgagatc ggccttgtgc 679621 acacgcagct gattgacagg agcggtaaac tagaattcgt taaggggctc ggcatcgaat 679681 tcgacctttt tttggaggga gagccgtaca accgccattt ccgctttgcg ggagagaaag 679741 ggatgtataa agaacccgcc cagctgtttg gcacacgtaa attcaatgaa cgatatccgc 679801 tttatgaaaa acaaatcaat ggcgaaatgc tgtctccaga tgaagagcat aaggaatggt 679861 ttgcacatgg cacacagaat gcggtttggg acgatgtcaa gatcgtgcaa gattccagcg 679921 atcattacag cctgtcaaaa cggaccggaa aagattatgc gtgggttgga atgctgcatg 679981 gcagccgggc gaaggggctc tgctatgcgg gcggaaaaaa tggcggtgtg gctctcggcc 680041 tgcggtattt ctttgagaaa tatccttcag cactggaaat cacaggtctt gccggcagcc 680101 gccccaaaat gactatctgg ctttggcctc cggacggcga agcgatggat ttgcggcatt 680161 atacaggaaa cactcacgtg gccagcgcgt atgaaggctt tgatgaaatg cgctctgatc 680221 cgacaggcat tgcgaacaca aatgaaataa gcctggcgtg cttttcgcac atgccgtctg 680281 acgaagtcct caatgcgctg gctgacaaat ggcaggcgcc cccgctcatt gtatgcgagc 680341 cggacgtcta ttacgaatca aaagcactcg gggtatggag catcattgac acatcccatc 680401 cgctcaaaaa agagctggaa gaacagcttg atgcggcctt tctgttttat aaaaaggaag 680461 tagagcaacg cagatggtac ggtttttggc attatggcga tgtcatgcat acgtatgacc 680521 cgatccggca tatgtggcgg tacgatctcg gcggatacgc atggcaaaac aatgagctcg 680581 ttccgaccct atggctgtgg caggcgtttt tccgctcagg cagagaggat atcttccgaa 680641 tggcagaagc catgacccgc catacgagtg aaacggacag ctttcacctc ggtgaatatg 680701 ccgggcttgg ctcacggcat aatgttgtgc actggggatg cggctgcaag gaagcgagaa 680761 tcagcatggc cgggcttcat aaattctatt attatctgac gggtgatgac cggacgggag 680821 atcttttgac agaagtgaag gatgccgatt atgcccttgt caaaaccgat ccgatgcgcg 680881 ctttttacga gaaaggcaag cacccgactc acgccagaac gggaccggac tgggcggcgt 680941 tttgctcgaa ctggctggcg gaatgggagc ggaccgaaaa ttcggaatat ctcaaaaaaa 681001 tcgaaacggg aatcaactgt ctgaagcggc tgccgctccg cttattatct ggcccgacat 681061 ttgaatatga tccggcgacc tcgatgcttc atcatatggg agacggcatt gcgggcggat 681121 atcatatgat cattgccttc ggcgcgccgc aagtgtggat ggagctggct gagcttcttg 681181 atgactggga atgggaggat atgctgagtg aattcggcga attttacaca ctcagtgatg 681241 aggaaaaacg aaaaaaaagc ggaggcgctc ttcatgacgg gcattttcac tggccgatgt 681301 tcgccgccgg tatgacagcc tacgccgcaa gaaaaaagca agatcctcat ctcgccgcca 681361 aagcgtggaa tcttttgcta gaagataagc tcagccatac gccgcttccg atcaaaccgg 681421 agcgcatcga gacatggacg cagctagagg agcttccatg ggtgacaacg aacactgtct 681481 ctcaatggtg tttaaatgtc atagcggcgc tggaactgat cggagattcc cttccggcaa 681541 aaaaagaaac atcgggcaaa aaaggataac agccggaatt tcataggaga aatggtgcaa 681601 aaaatgaaga ttgcaagaat ttatgtaagc gctttatatt gagaggggca aaggggaaat 681661 gcaaattgaa aaaaggggga cttacgcaac atgaaaataa gaatgcgaaa aaaatggatg 681721 gccttgccgc ttgctgccat gatgatcgcc ggatgcagcc attcggaaac atccaattca 681781 gcaagcggtt cgaaagatac gatcaaaatt atggcgccgc tcttatcgcc ggaaagccca 681841 agtgataaga gcccttcatt aaaagcgctc gaaaaataca caggcaaaga gattaaggtc 681901 acatgggtgc ctgattcatc ctacaacgac aaattcaaca tcgtcatggc ttcaggagag 681961 atgcctcacg cgattgtcat taaagataag tcagccggct ttatcaaatc tgtcaaagca 682021 ggggcgtttt gggagctgtc tccttattta aaagactaca agaatttaag ccaggcagat 682081 gaaaagattt tgaagaacag ctcggtgaac ggcgaggtgt acggaatcta cagaacgagg 682141 gatctgatca gggcgtgtat gatcatcaga accgactggc tgaaaaatgt cggtctggat 682201 atgccggaaa cgcttgatga tttctatgaa gtgctgaaag cctttaagga aaaagatcct 682261 gacggaaacg gcaaggatga tacgtacggc atggtcgtgc cgaaatggat gggactcggc 682321 aacggaagcc catgggatgt tctgcaaatc tggttcggcg ctccgaaccg ctacggtgtt 682381 gaaaacggaa agctgattcc agattttaca acgaaggaat acatggatgc gctcacgttt 682441 tttaaaaagc tctatgatga gggcttgatc aataaggact ttgctgtcat ggattctgcg 682501 aagtggaatg atccggttgt aaaaggaaaa gcgggtgtca tcgttgatac aggctcaaga 682561 gcgtctcaaa tccaaagcgc gatggaggag gcggatgagt cgaacaagga tatcattgat 682621 atcgtcggct cgcttgaggg accgaatggc aagcgcacct tcccgacatc tggttattca 682681 ggcatgatca cgataccaaa atcaagcgtc aaaaccgaaa aagagctgaa agaggtgctg 682741 tccttcctcg ataagatgaa tgataaggaa gcgcagattc tcacgaacaa cggagtgaag 682801 ggccgcaatt acgagctcaa ggacggcgta ttcacctcac ttgaaaaaaa caataaatct 682861 ctcctgtatg agcatgaagg cttggcacag ttcagcatgt cgattccgaa aagcgagtat 682921 tacatcgaag accagaaaac caagctcttc cagcatcgca aggacatcat aaccgaagga 682981 gaaaaaatag ccgtctttaa ccctgctgag tcgcttgtat ctgatgtcta tacccaaaaa 683041 ggagcccagc ttgacaacat catcctcgac gcgagaacac aatttatcat tggagaaatt 683101 gatgaaaaag ggttcgatga tgcggtggag ctttggaaaa aaagcggcgg caatgaactg 683161 atgaaggact tgaacaaatt gtaccaatcg tcaaaataaa ccgatgcgcc tgcctttcgg 683221 cgggcgcccc ggtatcacga aaggagaaca gatatggaaa cagtgccgaa gaagagagat 683281 gcacctgttc tcaccgctgg aaaaggcatc agctggatgg ctgcgctcaa acgggacaaa 683341 tggctttatc ttcttcttat tcccggtctg ctttatttct tgattttcaa atacttgccg 683401 atgtggggtg tgctgatcgc ttttaaagac tattcgccat atctcggctt ctggaaaagc 683461 gaatgggtcg gctttgatta tttcaaagac ttttttatga atccggattt tttccggctg 683521 ctgcgcaaca ccctcatgct ggcgagtctg gatcttttgt ttgcctttcc cgcgcctctc 683581 attttggctc tgcttttgaa tgaggtaaga aaggccgtgt ataaaagatg tatccaaacc 683641 tttatttacg taccccattt tgtatcatgg acaattgtgg tcagcatcac cttcgttttc 683701 tttactgtcg atacaggtgt gatcaacaaa ttgattatga gcctgacagg tgagcagatt 683761 tctttcttgt cggatgcaga ctggttccgg ccaatgattg tgatgcaaag catttggaag 683821 gagacaggct ggggaacgat tctatttttg gcagcgcttg ctacggttga tcaagagcag 683881 tatgaagcgg ccatcatgga cggagcgggg cggttcagga gaatgtggca tattacgctg 683941 ccggcgatta gaagcaccat tatcgttttg ttgattttaa gaatcggcag ctttttgaat 684001 cttggctttg aacaggtgta tttgatgacg aactcactca accgcagtgt ggctgacatc 684061 ttcgacacgt atgtgtacat gatggggatt acccaagggg cgtatagcta cagcacggcg 684121 gtcggtttgt ttaaatcagt tgtcgggatt atcttgattt ttggcgccaa ttacattgcg 684181 aaaaagtttg atcaggaagg attgttttag aggagggaga ggtatggctg aaattcacac 684241 gatgcacaac accaaagccg gacgggtgtt tgacgtctgc aacattctgt ttctcggcgg 684301 tgtcggcgcg attaccattt tgccgttttt atatattatc gccggttcct ttgcgacaga 684361 agcggaactc gcccagcgga gcttctttat tttcccgaaa acctttacac ttgatgctta 684421 caagtatgtg ttttcgacac cgacgttcct tcgaagcatg ggcgtgtcca tcttcatcac 684481 ggtggttggg acggctgtac agctgttttt taccttcacg atggcgtatc cgctggcgaa 684541 acggcatgtg aagggacgga atctgctgtt gaatctggtg attttctcca tgctgttttc 684601 aggcggcatg attccgacgt accttgtcgt aaaatcactt ggccttttgg atacgtattg 684661 ggcattgatt ctgccgatgg cgattaatcc gttcaacctt attattatca aaaacttctt 684721 tcagcagctg ccgcgcgagc tggaggaatc agcaaaaatt gacggctgtt ccgaaatcgg 684781 cgtcttctgg cggatcgccc tgcctctgtc aaagccagtt attgcgacct ttgcgctgtt 684841 ttatgcggtc gggatttgga atgatttctt ccacgctctc ttatatatca atgacagtgc 684901 aaaatggccg ctgcaaatgg tgcttcgcca agtcacaatt ttatcggatt taacggcgac 684961 caatggtgat acgatgcaaa atgcagttcc gccggagcag ggaattaaac tcgctgtcat 685021 tgtcattgcg acgctgccga ttttggcggt ctatccattt ttacaaaaac actttgcaaa 685081 aggaatgctg atcggttcgg tgaaaggctg agaaagggag tgtttcatat cagtacatta 685141 gatcagatta agattgccta tatcggcggg gggtcccaag gctgggccag aagcctgatg 685201 agtgatttgt cgattgatga acggatgtca ggcacggtgg cgctctatga tcttgatttt 685261 gaagccgctc agaaaaatga agtgatcggc aatcacagcg ggaacggcag atggagatat 685321 gaggctgttt ctactttgaa aaaggcgtta tcagccgcgg atatcgtcat tatttccatt 685381 ttgccgggat cactggatga tatggaagtc gatgtgcact tgcctgagcg ctgcggtatt 685441 tatcagtctg taggtgatac tgtcgggcct ggagggatca tcaggggctt gcgtgctgtg 685501 ccgatatttg cggaaattgc ccgggcaata agagactacg cacctgaatc atgggtcatt 685561 aattatacaa acccgatgtc tgtctgtaca agagtgctgt ataaagtgtt tcccggcatc 685621 aaagcgattg gctgctgcca cgaggtattc gggacgcaaa agctattggc ggaaatggtc 685681 acggaaaggc tggggattga ggtgccgcgg cgtgaggata tccgcgttaa tgtgctcggc 685741 attaaccatt ttacatggat cacaaaagcc tcttaccgcc atattgacct gttgcctata 685801 ttccgtgaat tcagcgcgca ctatggggaa tcaggatatg agctggaggg ggaatgctgg 685861 agggacagcg tcttttgttc ggcacaccgt gttgcgtttg atttatttga aacgtatggc 685921 gccatccctg ctgcgggtga caggcatctg gcagagtttc ttcccggccc atacctcaaa 685981 cagcctgaag tatggaaatt tcatctcaca cctatatcat tcagaaaaca agacagagct 686041 gagaaacgac aagaaacaga acggttgatc gtgcaacaac ggggcgttgc tgagaaagct 686101 tcgggagaag aaggcgtgaa catcatagcg gctcttctcg gattgggtga actcgtcaca 686161 aatgtaaata tgccgaatca aggccaggtc ttaaaccttc ctatacaagc cattgtcgaa 686221 acaaacgcat tcatcacaag gaaccgtgtc cagccgattt tgtccggagc gcttccgaaa 686281 ggtgtggaaa tgctggcggc taggcatata tccaatcagg aggcagtggc ggacgcaggt 686341 ttaacaaagg atactggcct cgcgtttcaa gccttcctca atgacccgct tgtccagatt 686401 gaccgcagtg atgcagagca gcttttcaat gacatgctcc aatgcatcat gcaaagctga 686461 gcttgccgat tagctctttc cggtttagaa aggaaagcat tgaccatact gatagtataa 686521 tcaagaagta ggtgctatca atatgggaaa ttatttaagt gttgcggtag aactggtctg 686581 cggtttaggc attttattta tcatcttaaa gcttctcggg aaaacccaat tttctcaaat 686641 tacgccgttt gactttattt ctgctttaat tttaggtgaa ttggtcggaa atgccgtcta 686701 cgatcatgaa atcaaaatca aagaaattat ttttgcttcg ctattgtggg gcgtgctgat 686761 ttatattatt gaatttatca cgcaaaaaat gaaatcatcg cgaaagttct tggagggcga 686821 gccgaatatc gtcatccgca aaggggagct tcaatataaa gtaatgaaga aaaataagat 686881 agacattaac cagctgcaaa gcctattgag gcaagctggg agcttttcga tccaagaagt 686941 agaatatgcg attcttgaaa caaacgggat ggtcagcgtg cttccaaaat cagactttga 687001 caaaccgaca aataaggatt tgcagattcc ttcgaagtcc gtttctctgc cgatcacgtt 687061 aatcatagat ggagagattg tgcgggataa tttgaaggaa gcaggtgtgg atgaacagtg 687121 gctgaaacaa gaattgaaaa agaagaacat tgataagaca gaggacgtgt tatttgcaga 687181 atggcataaa aataagccgc tgtatactgt aacgtacgaa caaagcagat caacatgact 687241 cttagaaaaa agcttgcagc aaggcgcaag ctttttattg attgtatgtc ccttgtttga 687301 cagcacgtac atggtacatg ctcacttcag tgctgatcag atagtcaggc tttggtttgc 687361 ctttgtttgc tttatggccg gcgatatgcg catcgctttt ttcccattgc ttccagtgat 687421 cctctgattc ccagcgaatc atgacaacaa cttcttcatc accgcggcgc acatttttct 687481 caagcactgt cacatcaatt aaaccttctt gtttttcaat gattccttca gcgctgaaac 687541 gttctatgac tttatctgca aagccttctt taaccgtcat ttttctcaac tgtacaaaca 687601 tttgtctcac tccaatcatt ctcacatatg aataattgta aatgaaattc attctcaatg 687661 tcaaagaaag cgcagggcgg aatcgaaccg ccgtgcgcaa cagtttattc ttttaataaa 687721 aacacatttc cgtcttcgtc cttaaattga acgaaggtgc cccactccat ttgattgggc 687781 tcaccgagaa attctacacc gtttgtcttc attttctcgt atgtaccaaa gatgtcttcg 687841 cattcaaaca caatagaagc cttcatttgc tctgagcctt tcatcatggc tttcgggtaa 687901 atgactaaac gagtctcggc tccttttggc gcaacctcca gccagcttgc ttcaggtccc 687961 attgggtgat ccgctgcaat atcaaagcct accttctctg tccaaaattg cttcgctttc 688021 tgctggtcct cgacatatac agcaacagtg ccaatttgtt tgatcatagg gaaacctcca 688081 agttgaaaag ataataatac tataacctgt ttacggccga agtaacataa aaaaatcagc 688141 cgggaaaccg gctgattatt aaaatgagca gcttacaaca tcgatgtgat ttgtgtctaa 688201 ggcgaaataa acccagcggc gccgtgagga atcccaataa aagccgccga cggatcttct 688261 gccaaggatg atcgggtaaa accaaaatga gcggccattg gttaaccaga cataggtaaa 688321 tcggaaaagg caaggacgaa tggtgattgg ttcaactaac aaaacggctc cttgagaacc 688381 ctgcggtttt gggggtttcg ctggtatttg ggaaggagga ggtccctgcg gcgcaccgcc 688441 gaagcctggg ctggcaccgc tgccaatacc agggccggag ccgccgccaa agcctggaac 688501 agcaccaccg ccaatgccag gaccggagcc gccgccagag cccggaacag cgccgctgcc 688561 aatgccaggc catggatatc ggtattcata ttcaaaagca ggccaaggct cataaaaatg 688621 ccccgcaaac atataaggat caacataata catgtgataa cgtcctttct cattgtaaac 688681 tgtacattgc agtttatgcg ggcggactct tattggtgca ttcgcctaag gatatgaagc 688741 tggaatgctc tcagagagca gaatcatttg atttttctct agtcttattc acaattccga 688801 tttatcattt tataatgaaa gtgcttctat tacgaaaaag gagacagacc gtgaatatcg 688861 atcaattatt atatcaatat atcatagaca acactgcgga tattactgag aaatggttca 688921 gtttgcgttg ccagctaaaa ggcgagctat attccgccag ccatttaagt gaagaaacga 688981 aaacactttt aaccgagcag catacattta ccaatataac aatcgcaagc gcatttctgg 689041 aggatcaaac cgattttcaa gaaaacatga caaaatgggc gcaaaacgtt gcgaaaaaca 689101 gggtagagca ggatgttcaa gtgcatgagg tcgtagaagc catatccaat tcaagaatct 689161 cattctggga cgcagtcgcc acatttataa aagagaatca ggagattgtg acaaatgagg 689221 atgcagaccg atggaaccgc attgtgaatc agtcgttcga taagctgatt attgaattct 689281 ccgagcagta ccaaaaattc atgctgatga ggcttacatc tcagcaggaa ctgatctcag 689341 agcttggctg cccggtcatt tccattgccg atggaatcgg gatattgccg cttatcggct 689401 ccattgatac aaaacggcac aggtcatttt agaaacagtg ccggtccgct gtgtcgagag 689461 aaaaatcaca agcctcgtcg ttgatctttc gggtgttccg attgtggata ccatggtggc 689521 tcagcaattg tacaacctgt ctaaaacact tttcttatta ggcgtcaaag ccgtattttc 689581 aggaattcgc ccggatgtgg cccaaacatc gattcaattg gggcttgatt ttagtgaata 689641 tgaaacgtac ggcacgctga agcaggcatt agaaaacatg ggtgtccgct gtattgttga 689701 ggaattggaa gaaaacaaat aggaagtttc caggcatatg attgtccgtc accgggtgat 689761 catatgcctt tttgatttga acagaaatca ccattgattt atcgaaaaaa acataatatt 689821 ataattctta taagaatact gtgaattaaa acctattcaa caggggggaa ggtcttttgg 689881 tttctaaatc aacgattgat ccggaagtga ttgaaaaaat catcagctcg ctggaaacac 689941 tcgatttcgg cacggttcag attacggttc atgattctca gattacccaa attgagaaaa 690001 tagaaaagca ccgtttttcg ctgaaaagga aagaatcaaa atgataatgt aaagggcgtt 690061 tgttttcatt aaattctcct taaaacatat acatatttca tccaattttt atataataga 690121 cctttaagat cattttttag gaggattttt gacatgcaag ctacggttca cgagagtaag 690181 caatcgatca tgcaacgcat tttgacagtc tttgtcttca cattgctgat cgcgactgtc 690241 ggccttttta tcggccaatt tgttcctgtc gctttgatgc tgccgctttc tattcttgaa 690301 gtggcgatga ttattctggc cttctggatg cgcagaagaa aagcggtcgg gtatgcgttt 690361 gtatatacat tcgcgttcgt ttccggcatt accttatttc cgatcgtcag ccattacgct 690421 tccatcgccg gcgcctatgt cgtgctcgaa gcctttggct ctacatttgt catttttgcc 690481 gtcttgggca caatcggcgc aaaaatgaag aaggatttat ccttcctgtg gtcgtttctg 690541 ctggttgcgg tgctcgcact cgcagtggta gggattttca acattttcag cccgttaaac 690601 tcagcggcga tgatggcgta ttccgtgatc ggaaccatcg tcttttccct ttacattttg 690661 tatgatttga accaaatcaa gcaccgccac attacggaag acttgattcc ggttatggcg 690721 ttatcgctgt acctagactt tatcaacttg ttcatcaacc tgctccgctt cttcggcatt 690781 ttgagcagtg atgattaatg aaaaagcgtc tgtcattgga taggcgcttt ttgccataca 690841 tcaaaaaggc aggtggagta ttggtgaaaa aacaaatggg cgcatatgta tctctggcag 690901 cagctatggc gatcgtcggc agttctgtcg ttgtcggcaa gctgatggtc gaacggattc 690961 cggtctttct ttcctcagga ttgcgttttt tgatcgcttc tgtcgtattg ctcatgctgc 691021 tgttttgcat tgaaaaaggg tttccggctt tgacgaaaaa agatgtgttc gtattactgg 691081 tgcaatcatt cacaggcgtg tttttgttca gtatttgcct gctgtatggg gttcaatata 691141 cgacgggaac ggaaagcggc attttgacaa gcacaacccc catgttgatc ggtattttat 691201 cctttttcct gctgagagaa aaaattgaga aaaagacgct gatcggcatt ttgctggcgg 691261 tttgcggcgt aatggcgatt aatttgtttg gagccgggag ccaagacggg acgccgcacg 691321 ccttattcgg gaacatgctg atcattgctg cagtcattgg cgaagcgttg tttacattga 691381 tggccaagct gctatccccg catatttcgg cactggcgat ttcgaccttc gtatcgctct 691441 tcggcttcct gttttttctc ccgtttgctt tgtttgaggc ctcttcattt gattacagcg 691501 tgccgactgt tttggattgg tcgtatgtgc tgtattacgc gctttttgtc actgttttgg 691561 cgttttactt atggtatagc ggggtgacga aggtgccggc gggtgtatcg ggcattttca 691621 catccgttct tccggtctca gctgtcattt tgtcaggcgt gatattgaag gagccatttg 691681 agtttgtgca tttcatcggc attgcatgtg tcatcggcgg catatttgtt acggtcataa 691741 agaaaaaaca gccggatgcg tatccggctg cagaagaaaa gacgctatag cctgtccgga 691801 tcggacgggt tttttagtct ttaaacacgc tcagcctttc aaaaagatca ccaagcatct 691861 tcacgaacat gtctttttcc tcgtcgctgt agttttccat gacagcggat attttgctga 691921 aatggccggg cagaaattgc tccaggcgtg ctttgccttc tgttgtcagt tcaatgctga 691981 tttttcgttt atcctctgtg tgatgcctgc ggctgacaaa accgtctctc gccagcccgt 692041 ctagcaggcc tgtaattgtt gctttcgtga catttgaccg cttggcaagc tctgtcggac 692101 ttaacctatg atccttggca tcaaagagca gcatcaggat tttgaatttt ccttctgaaa 692161 gccctcggcc agcaaagtaa tgctccatca catgattcat tttttttgaa atatcaaaaa 692221 gagataaaaa caattcaaga gagccggcgt caatattggc atacgtttcg gcgtgctctg 692281 ttatatgctt atatttcggt aaatgtttta attccatcgc aattagctcc cgtacattcg 692341 ttgtgacacg attataaagg agggaaaacc ataacgcaac ttggcttgga gatgattgac 692401 agcttttctt gggacatagt aaggtaatat agttaggcgc ctaactaata catatagagc 692461 tgaaaaggtg gttattgata tgaaacatat gttaatagca ggaggcggaa tcggcggctt 692521 gtcagcggcc atttctctcc gtaaggcagg gttttccgtc accttatgtg aagcggcttc 692581 agaaaatcga aaaacaggtg cggggattct tcagccgcaa aacgcactgg cggtgttgaa 692641 agaactgggc gtattcgaag attgctgtaa gcacggcttt caaacagaat ggtttaaaac 692701 gtttgatgaa caggggaatt tgctgtttca agtcagtgaa tcctttttag acgattcact 692761 tccgggacgc aataatatcc tgcgcaaaac gttaaatgac attctcatga agcatgccga 692821 ggcagtgggt gtagacatca agtgggggaa aaaggttgtc gcctatgaag aaactgctga 692881 atcggtcact gccttatgtg aagatggaga aaagatgcag gctgacattc tggcgggctt 692941 tgacggcatt cactccgttg ttcgtgataa gatgctgcaa aaggaaacgg aaaaagagca 693001 tctcggcatg ggagcgtggc gcttttatat cgaacttcct gattacacat tcgaggacgc 693061 aacattcatg tatagaagcg gagacacaca aatcggggtg gtgccattgg cacaacacgc 693121 tggctatgtc ttcgtcctcc agccttgcac gagcgattac tgggatgagg aagatacccg 693181 gtttgataga gtaaaagaga ttctttctgg ttttcggggg ctggattttg tcacaaagca 693241 catgtcaaaa cagcatcctg tcatctttaa caaactggag caggtcgccg tgcaggagcc 693301 atggcataaa ggccgcgtca tcatcggagg agacgccgcc cacgccggtg cgccaaccct 693361 ggcacaagga gcggcaatgg cgatcgagga tgccatcgtc ctcgccgaag aactccaaaa 693421 ccacgccgac cacgaaacag cattacaggc gtactataaa agaagagccc cacgagcgct 693481 caaagtccag aacctatcat ctgaaatcgt ccgccgcagg ctgaaaggag agccgggagc 693541 ggaagaactg attggggagt gctatgcggt gttgagggaa gggtattaaa taggaaaagt 693601 ccagaaagtg atttctggac tttttagtct tgctctgttt tattccttat ccgctcaatc 693661 acctcatgca gcccctcagg cttataaaac tccaccggtg aactgccttt ctcaaacgaa 693721 atcgtctcgg cttcaatcag cgcgacatag cgcccgttta cttttgcgag atgaatagaa 693781 tcgccaaaat ccgctagcaa tcccttaatc tctgtttctc cgactttcat tttcagctgg 693841 gcctctggcg tgtgctcgat gatttgggcg gaggcttcga tgacttgatg ggtgtcgagg 693901 cgctcttgga tttcccgttt ttcgcttgct tcccaaatct caatgtcgtg ctcgaactgc 693961 ttgagttctt cgctgttgtc ttcaaatgtc tcgtagacgt gctcttgtac catgttcatg 694021 acctgatttt tcatgatttc tggcatcgat tctccgtact cgacgaattt cagaaagtcc 694081 tcaaaatagc gggcgtgcga ggcctggtgg attttcagtt caccttcctc gaccattcct 694141 tcctctggca tgtacgggta ttggatgctt ttcatgtttt ttgtcgtgat cgccatttcg 694201 acttttttaa tgagagaaga cgcgtcagag atgcgggcga ccttcggctc aaaatcacat 694261 ttcataatga agacaaatga ctcatcaaag tattttctcg gcacggccga agcgacgaga 694321 aacacgccgc cgcgaaccgc gcttgtgtca aggtacgtgc ggacgaactg ctcgctcagc 694381 tcattgaagt cttcttttgt ttccgccaga cgcgcgcggt tgaacatgtt gtagtttggg 694441 ttggaatcga gctcgtggcc gggctcgacg ataaaatggc cgattttcgt cggcacctgc 694501 tcggactgcg gatggcggtc ggctttccgt ttaacgattt ttttcagttc cccgtcgaga 694561 aagtccttca gctcgctttc ttcaaattct cccgtatcaa gggtctggaa gtgcttgaac 694621 tgcttgttcg cctgctcatc tttgccttcc acctgtatga cataaaagga taaaaaccga 694681 atttcaaaat ccatatataa actcacctta ttcgcgtatt gtacagcttc tcaagtatag 694741 aaaaaacagc gatcatgcgt caattgggag aacggaataa tcatgaccat gaaagggaaa 694801 tgtagtcaaa tagaaggcat ttcatacgga aaggaatggt tcgatgaagg aaacaagccc 694861 gattcctcag ccgaagacgt ttgggccgct cggcaatttg cctttaattg ataaagacaa 694921 accgacgctt tcgctgatca aactggcgga agaacagggc ccgatttttc aaatccatac 694981 acccgcgggc acgaccattg tagtgtccgg ccatgaattg gtgaaagagg tttgtgatga 695041 agaacggttt gataaaagca ttgaaggcgc cttggaaaag gttcgcgcat tttccggtga 695101 cggattgttt acgagctgga cgcatgagcc taactggaga aaagcgcaca acattctgat 695161 gccgacgttc agccagcggg ccatgaagga ctatcatgag aaaatggtcg atatcgctgt 695221 tcagctcatt caaaaatggg caaggctcaa cccgaatgaa gcagtcgatg tcccgggaga 695281 tatgacccgg ctgacgctcg acaccattgg gctatgcggg tttaactacc gctttaacag 695341 ttactacaga gaaacgcccc acccgtttat caacagcatg gtgcgggcgc ttgatgaagc 695401 gatgcatcaa atgcagcggc ttgatgttca agataagctt atggtcagaa caaagcggca 695461 attccgctat gatattcaaa cgatgttttc gttagtcgac agcattattg cagagcgcag 695521 ggcgaatgga gaccaggatg aaaaagattt gctcgcccgc atgctgaatg tggaagatcc 695581 ggaaactggt gaaaagctcg acgacgaaaa tatccgcttt cagatcatca cgtttttgat 695641 tgccggccat gaaacaacga gcggcctgct ttcctttgcg acttactttt tattgaagca 695701 tcctgacaaa ctgaaaaagg cgtatgaaga ggtcgatcgg gtgctgacgg atgcagcgcc 695761 gacctataaa caagtgctgg agcttacata catacggatg attttaaatg aatcactgcg 695821 cttatggccg acagctccgg ctttcagcct ttatccaaaa gaagacacag tcattggcgg 695881 aaaatttccg atcacgacga atgacagaat ttctgtgctg attccgcagc ttcatcgtga 695941 tcgagacgct tggggaaagg acgcagaaga attccggccg gaacggtttg agcatcagga 696001 ccaagtgcct catcatgcgt acaaaccatt cggaaatgga caacgggcct gtatcggcat 696061 gcagtttgcc cttcatgaag ccacacttgt gttaggcatg attctaaaat atttcacatt 696121 gattgatcat gagaattatg agcttgatat caaacaaacc ttaacactta agccgggcga 696181 ttttcacatc agtgttcaaa gccgtcatca ggaagccatt catgcagacg tccaggcagc 696241 tgaaaaagcc gcgcctgatg agcaaaagga gaaaacggaa gcaaagggtg catcggtcat 696301 cggtcttaac aaccgcccgc ttctcgtgct gtacggctca gataccggca ccgcagaagg 696361 cgtcgcccgg gagcttgctg atactgccag tcttcacggc gtaaggacaa agacagcacc 696421 tctgaacgac cggattggaa agctgccgaa agagggagcg gttgtcattg tgacctcgtc 696481 ttataatgga aagccgccaa gcaatgccgg acaattcgtg cagtggcttc aagaaatcaa 696541 accgggtgag cttgagggcg tccattacgc ggtatttggc tgcggcgacc acaactgggc 696601 gagcacgtat caatacgtgc cgagattcat tgatgagcag cttgcggaga aaggcgcgac 696661 tcggttttct gcgcgcgggg aaggggatgt gagcggtgat tttgaagggc agcttgacga 696721 gtggaaaaaa agcatgtggg cggatgccat caaagcattc ggacttgagc ttaatgaaaa 696781 cgctgataag gaacgaagca cgctgagcct tcagtttgtc agagggctgg gcgagtctcc 696841 gctcgctaga tcgtacgaag cctctcacgc atccattgcc gaaaatcgtg aactccagtc 696901 cgcagacagc gatcgaagca ctcgccatat cgaaattgca ttgccgccgg atgttgaata 696961 tcaagagggc gaccatcttg gcgtattgcc aaaaaacagc caaaccaatg tcagccggat 697021 tcttcacaga ttcggtctga agggaaccga ccaagtgaca ttgtcggcaa gcggccgcag 697081 tgcggggcat ctgccattgg gccgtcctgt cagcctgcat gatcttctca gctacagcgt 697141 cgaggtgcag gaagcagcca caagagcgca aatacgtgaa ctggcgtcat ttacagtgtg 697201 tccgccgcat aggcgcgaat tagaagaact gtcagcagag ggtgtttatc aggagcaaat 697261 attgaaaaaa cgaatttcca tgctggatct gcttgaaaag tatgaagcgt gtgacatgcc 697321 gtttgaacga tttttagagc ttttacggcc gttaaaaccg agatactatt cgatttcaag 697381 ctctccaaga gtgaatccgc ggcaagcatc gatcacagtc ggtgtcgtgc gcggcccggc 697441 gtggagcggc cgtggcgaat acaggggtgt ggcatcaaat gatttagctg agcgtcaagc 697501 cggtgatgat gtcgtgatgt ttatccgcac accggaatcc cggtttcagc ttccgaaaga 697561 ccctgaaacg ccaattatta tggtcgggcc aggcacggga gtcgcgccat ttcgcggttt 697621 ccttcaagcc cgcgatgttt taaagcggga gggcaaaacg ctcggtgagg ctcatctcta 697681 ttttggatgc aggaacgatc gggattttat ttaccgagat gagcttgagc ggtttgaaaa 697741 agacggaatc gtcactgtcc acacagcctt ttcccgaaaa gagggcatgc cgaaaacata 697801 tgtccagcat ctcatggctg accaagcaga tacattaata tcaatccttg accgcggtgg 697861 caggctttat gtatgcggtg atggcagcaa aatggccccg gatgtggagg cggcacttca 697921 aaaagcgtat caggctgtcc atggaaccgg ggaacaagaa gcgcaaaact ggctgagaca 697981 tctgcaggat accggtatgt acgctaagga tgtctgggca gggatataga taaagaagac 698041 tggagacatc cagtcttttt agtcctttcg aaaaaatggt gatcgcgcta aacattgatg 698101 catacaataa cttcagtccg ccggaagggc gggctgtctg caaaacctat ttttcgtttt 698161 tgctagttta tgttattctt atactcggta tctatttctt ttttcaaagg cacacatgac 698221 aaaagaaatc ctttttttat ttccgagaaa aaaatgtgaa acgaaatgaa ggtttctttc 698281 gtccagtgat tggtttccaa atggttgtaa taaaaatgat atggtgcgaa acataaatat 698341 tccggcttgc cgcggtgtat ttattgttgt gtgatgcctt gattttgttt ggaaagaagg 698401 aattggaagg caggatataa agagcaggta aatatgaatg aagaacttaa agtgtttaag 698461 aaagtagagg ttgccatgaa gaaacttttt tcttacaaac ttagcttttt tgtgctggct 698521 gttatactgt tttgggcaaa aacgtattta tcctacaaga ctgagtttaa tcttggggta 698581 aaaggcacaa ctcaggagat cctcctgata tttaacccat tctcaagcgc cgtcttcttt 698641 ttaggactgg ctttgctggc gaaagggcgt aaatcagcca ttattatgct gattatcgat 698701 ttcttgatga catttgtgtt atatgcaaat attttattct atcgtttctt tgacgatttc 698761 ttgacgttcc cgaacattaa acagtccgga aacgttggaa acatgggaga cgggattttc 698821 agtatcatgg ccggtcatga tattttctat ttcttagata ttatcatttt gattgcggta 698881 ttgatctgga gacctgaatt aaaagaatac aaaatgaaaa aacgctttgc atctttagtg 698941 atcctttctg ggatcgcact gtttttcatc aacctgcact atgcggaaaa agaccgtccg 699001 caactgctga caagaacgtt tgaccgcaat tatattgtga aatatttagg tttatacaac 699061 tacaccattt atgacggtgt acagacggct caaacagaga cgcaaagagc ctatgcaagc 699121 agcgatgatt taacaagtgt cgagaattac acgacgtctc attatgcgaa accaaacgcc 699181 gagtacttcg gctctgccaa aggcaaaaat atcattaaaa ttcacctcga aagcttccag 699241 tcattcctga ttgactacaa gctaaacggt gaagaggtga cgcctttctt aaataaactt 699301 gcgcacggcg gggaagatgt gacgtatttt gataacttct tccatcagac aggccaggga 699361 aaaacatctg atgccgagct gacaatggat aactcgatct tcggtcttcc tgaaggctcc 699421 gcgtttgtga cgaaaggcga aaacacctac cagtcgcttc ctgcgatttt agaccagaag 699481 gaaggctata caagcgccgt cctgcatggt gattacaaat cgttctggaa ccgtgaccag 699541 atttacaaac atatcggata tgacaagttc ttcgacgcaa gcacgtatga tatgtcagat 699601 gaaaatgtga ttaatatggg gcttaaggat aagccgttct ttacagaatc gattccaaag 699661 cttgaatctc ttaaacagcc attttatgcg catttgatta cattgacaaa ccattatccg 699721 tttaaccttg atgaaaaaga cgcgtctctt aaaaaagcga caacaggcga taacacagtt 699781 gacagctact tccagacagc gcgttacctt gacgaagcgc ttgagcaatt cttcaaggag 699841 ctgaaggaag ccggcctgta tgacaactca gtcatcatga tttacggtga ccataacggt 699901 atttctgaaa accataaccg agcgatgaaa gagattcttg gaaaagagat cacagattat 699961 caaaacgcac agaaccagcg tgtgccgctg atgatccgcg ttcctggcaa aaaaggcgga 700021 gtgaaccata cgtatggcgg cgaaattgac gtcatgccga cacttctgca cttagaagga 700081 attgattctc agaaatatat caactttggt actgatttat tctctaaaga ccacgacgat 700141 acggtggcat tcagaaacgg agacttcgta acgccgaagt acacatcagt cgacaatatc 700201 atttacgata cgaagacagg tgaaaaactg aaagcgaatg aagaaacgaa gaatctgaaa 700261 acaagagtga accagcagct gagcctttca gacagtgtcc tgtacaaaga cttgctgagg 700321 ttccataaac taaatgattt caaagccgtt gatccgtcag actatcatta cggcaaggag 700381 aaagaaatca aataagatga aaaagagcct tgagcgggcg cattgccttc gctcaaggct 700441 ctttttttgg ttatacaacc aacttgaaaa aatagattcc atttggtcac caaggctggc 700501 tttctctcat atcattacag tagattttga aaccggattg aaatcggaca aattatcggg 700561 gaaatgcctt gatagattgt gaagatgtac caggtttcga actcaatatt catagagatg 700621 aggggtagag atgaaagcgg tcattctctg cggcggaaaa ggaacgagaa tgagtgaagt 700681 cacgaatgac attcctaaac cgctcgccat gataggcggc aaaccgattc tatggcatat 700741 tatgaaaatt tatcagtact acggagtaaa cgagtttatt ctgcttttgg gctataaagg 700801 agaaaaaatc aaggaatact ttctcgacta tgaatggaag cacaacagcc tgacactcga 700861 cagctctacg ggagaggtac agatgctggg gcagcctgaa acgtggaaaa ttacgttttt 700921 ggagactggg gtagatacgc tgacagccgg aagaatcttg caggcgaaag actatatcgg 700981 tgatgaaaca tttctgctca cctatggaga cgggctggcc aatatcaatc ttttccatct 701041 catcagctat catcagacaa aaggtgctgc cgcgactgtc accggcattg acaaagtctc 701101 gcagtttggc accttgacag ttgaggatgg catggcgaaa acattttctg agaagacatc 701161 aagtgatgga atcatcaacg gcggattctt cgttcttagt ccaaaggttt tcgattattt 701221 gccgaaggac gggaacacga tgttcgaaga tgaaccgctg aagaaccttg ccaaagatgg 701281 ggagcttgct gtgtaccgcc attacggatt ttggacggcc atcgatacgt ataaaaatct 701341 cttagaagtc aacaaaatgt ggaatcaagg acaacaagta tggaaggtat ggtgaattga 701401 tttgagtttc tggaaaaata aaaacgtatt tgtcacggga tgcacaggtc ttttaggaag 701461 ctatttggtg aaagagctga tcgaacaggg cgcaaacgtt acggggctag tcagggatca 701521 tgtgcctcaa tccaatcttt atcagggaga acatatcaag aaaatgaaca tcgtgcgggg 701581 ctctcttgag gacttggctg tgattgaacg cgcgcttggc gagtatgaga tcgacacagt 701641 ctttcatctt gctgcacaag cgattgtcgg cgtggcaaac cgcaacccga tttctacctt 701701 tgaagcgaat atcctcggca cctggaatat tctcgaagcc tgccgcaagc atccgttaat 701761 taagcgggtc attgtcgctt caagtgataa agcttacggc gatcaagaaa accttccata 701821 cgatgaaaac atgccgctgc aaggcaagca cccgtacgac gtctcaaaaa gctgcgcaga 701881 tctgatcagc cacacctatt ttcacacgta cgggcttccg gtctgcatta cgcgctgcgg 701941 aaacttatac ggcggcggag atttgaactt caaccgcatc attcctcaga cgattcagct 702001 tgtgctgaac ggggaagcgc cggaaatccg aagcgacggc acatttgtac gggactactt 702061 ctatattgaa gacgccgttc aggcttatct gcttcttgca gaaaaaatgg aagaaaacaa 702121 tcttgccgga gaggccttta acttcagcaa tgagatccag ctgaccgtac ttgaactggt 702181 agagaaaata ttaaagaaaa tgaacagtaa tctgaaacct aaggtgctga atcagggaag 702241 caatgaaatc aaacatcaat atttatccgc ggaaaaagca agaaagctgc tgaattggac 702301 accggcctac actattgatg agggacttga aaaaacgatt gagtggtata cggaattctt 702361 caaaaagtaa tgtgaaacga ggtgaacaag actgtgacca gcgcgtattg caccgtttta 702421 tcaaaaggaa gattatatca ggcagtcgct ttgtttaagt cgttagagca agttgatcaa 702481 gacagtccca tttttatact ttgcatggat gaagatacgc accgcgtgtt acagaagctg 702541 aagatgaagc agctgaacct tgtgccggtg gccgctcttg aaaatgaatt gctgctgaag 702601 ctgaaggaaa ctagagatca aagtgagtat tgctggacga tgaagccgat ctttctgcaa 702661 gctgtgctga acagcaatcc tgagctggag cgtgtgacgt atattgacgg ggatctcttt 702721 ttctatgcag atccatcgcc gatttttgaa aaccagccgg actgctcggt gttgctttca 702781 cgaggggata ttgtaatccc ttcttttgag aaagagcaga ttgacatgct gcagcgtctt 702841 ttaggcagat ataattccgg gtttatcagc ttcaagcatg atgatgcagg cacggattgc 702901 ttggagtggt ggaaggaacg ctgtcttgag gaatgcaaaa atgcaccggg tgaagggaaa 702961 ttcggtgatc agggctattt ggattatatg tctgagctgt ttccgaatgt gtgtgacatt 703021 acaacacccg gcgtgaacat cggccattgg aattatggac agcatacgtt ttcctggaaa 703081 gatggccgga tcgtgctgga ggatggcagt ccgctgatct tttatcattt cagcggatac 703141 cgaatcgtca gcatcaatga aatcaaacag attcatgaaa caacccgcac agatctgccg 703201 tttgtgcatg aactgtatca agagacactg ccgcatatca ttcagcacat gcaaacgtta 703261 gaccctgaat ttaacggttt tgcttcaaaa gatgacaaca aataaatgag taaatacagg 703321 aagtgaaaat gaagtgaaag caagcgttat tattcctgca tataattcga aggagcgtct 703381 ttacaacagc cttctgtcat taaaccagca ggagtgcgat gaagaatttg aagtcattgt 703441 agcggacaat ggctctgagg acgggacgct ctcgatgctt gagtcatttc aagctgattt 703501 tccgctgatc tttacacgga ttaaagaaaa caggggcatt gcgtacggac gaaatcaggc 703561 gcttcgcaat gccagaggag acatcctgat tttccatgac agcgatatgc ttgcggcaaa 703621 ggaccttgtg gcaaaacata ttaaagccca tgagaacgaa gagaatctcg tcgtgtgcgg 703681 gttgttttgg aaacggatct acagttttta ctatgaacga tttgaagaag aacataagga 703741 acagctcgca aagctcacag gtgaaatgcc gaagaaagac aaacaaaagc tgctggagga 703801 agcggacatc aaaaacggaa gctttcttga taaaagcttt gacctcgata ccgactttat 703861 agacgtgctc aagaagattt tagatgagta cggcgatgac ttgaaaggct atcatatgcc 703921 atggcgcttt tttatcacga ataattcctc tgtgaaacgc aagcatgtgg ttgacctcgg 703981 tttatttgac gaaggcattg tgcggtacgg gtttgaggat tatgacctcg ggatcaggct 704041 tcatcaggcc ggattgacct tcaggcttcg ccgtgatatt gtcagtgttc atcaggaaca 704101 tccaagcaat tgtaagtctg tagacgatat tcgggcaaac attgcctata tgtgcgataa 704161 atacaataac atccgctcct tagacgttca tctcgctttt aatgggccgt tcccgcctga 704221 catgacgaac agaatcatgg ctgatattca aaagctgctg gaatcacaga aatatgatat 704281 gctgctgaat ctgtttcttg agcttctgca tgttgttaaa gagcgcaaca ttgatccgga 704341 ttggcgaaag aaatccccaa gggtgacggc gaaaagcttt gatttgcaaa ctgtccgcaa 704401 gcttctgcct aaggcgaaga aaaagctagg cgtgaacgat tttgccaacg cactgtatgc 704461 gcttgtcaac gatttgctgc acgtggatct tagatcattg gatgtggtat aagtgagtac 704521 atttcatttt tcaacgatag tgtcaaggac acatatcttt aagctcatgc ctatgattca 704581 ttctctccat gagcattgcg atgattttca tttatatgtg ctgtgtgtcg accagaaagc 704641 gtatgaattg cttcagcacg ttccatggga gcatgtaacc tttgtgcagc tgcatgaaat 704701 ggaagacccg gagctgttga aagcgaaaag caacagaacg tttcatgaat attgctggac 704761 gttaaagccc gcctttttgt ttcatgtgat gagcaagtgg gatgacgctg aatactttgc 704821 ccatatggat acggatctat ttttcttttc tgatccggca cgtatttttg cagaaaaccc 704881 aacggcgtct ctgtatttga ctgatcatcg taattcgccg cgcttcatgt cctactacga 704941 ccgaaccgga cgctttaata caggctttgt cggcgccggt aatacaaagg aagcatatga 705001 agcggtgtgg cagtggagac aggactgtat tgaattttgc acggtcgaaa tggatacgga 705061 acgaaagaca tatggtgatc aaagatatgt ggagaaatgg ccggagcagt ttaaaggtgt 705121 tcatgttgtc aaatccatag gagccaatac agcgctttgg aatatcgaaa actataaggt 705181 cgggcaaaag gacggccgcg tgtatataga tgaaacgccg ctgattttct atcatttctc 705241 tgggtttacg ctggtgacag aaaaagagtt taatctttgc tggtactacc ggattgaaga 705301 cgaagcgaca attaagatga tttatatgcc ctatatatta aatctgaaaa gatggattga 705361 tgaaatacag tcggcgtttc cggactttgc ggatggcttt atcccgaagc acgcagtgcc 705421 tgacactcat tttatccagc tggattaaaa aaccccctgc cgcctggcag gggttttttc 705481 agctatgcca ttctctcagc ttctggtcac ttggcaatag gaaggcaagg atgccgagga 705541 cagggagaaa ggcaatggcg atcatcgtcg gggtcagtcc cgcggcatca atcagagcgc 705601 ccagcgccac agcgccgatt gcgcccatcc cgaaggcaag cccgacggtt aaaccggaca 705661 ttgtgccgat ttttccagga actagctcct gtgcgtagac gaccgttaca gaaaagctcg 705721 acatcagaac caagccaatc aatgcgagca cgccgtaggc gagaaccggg ccggcaaatg 705781 gcagcacaat cgccagcggc gccgagcata acagcgaacc gaggataacg aagcgttttc 705841 caaaacggtc tgcaagcggg ccgccgagaa acgtgccgat cgcgccgaac agcaagaaga 705901 caaaaatata gctttgtgcc tgctgaatgc ttacgtgata ggtatccatc gcgtaaaacg 705961 tgtaaaagtt accgatcgca ctcgtatacc aagaacgagc aaaaatgaga aatataataa 706021 taataagagc agatacaaca gatttggtga tggccgtgtt ttcagccgtt ttcttttgct 706081 tgcctgattt ctgggcaagg ctgccgagac gtgaggcgta ccatttcgca atatacatga 706141 gaaacataac agcaagcgcg gcgacaagcg tgaaccaaac agcgccgaat tgcccgagcg 706201 gcacaaggat cagcgcggtg atcagcggtg ccatcgcctg gcctgagttt ccgcccacct 706261 gataaatcga ttgggcgagc ccgcgttttg tgccggcggc catatacgcc acacgggagc 706321 cctccggatg gaaaatggcc gagcctaatc caatgaaaaa cacacagcat aagatcgtta 706381 tgaatgacgg ggcaaatgca aggcccaaaa tgccaagcat gctggcggtc aaaccgactg 706441 gcagcgcata cggccgcggc cgtttatcgg tataccagcc gacaacaggc tgcatgacgg 706501 atgacaccat gtttaatgtg aaagcaatga tgccgagctg tgtaaacgtc aggctcatgg 706561 agcgttccaa aatagggaac atggccggaa tcacagcctg aagcgaatcg ttgagcatat 706621 ggcaaattcc gataataatc aaaatcggat acaccgtggt gcctggtttt tgaactgttt 706681 tttcttttaa cggggcggcg atagccattg agtctcctcc ttacatatat aaccaaagca 706741 taccaccata ttattcataa ggtgaagaat ttatcaagag gaaaaaagat tcttatgaaa 706801 gaaataccgt cagcctgatt agcagctgac ggtattttcg atattcaaaa tgtgatatag 706861 ctcttcaagc ttacgaatct cataggttgg tatgatctct ggcacattcg gcttcatgtc 706921 agggttcatc cagcaagtat caagcccggc gagctgtccg cctttgatat cagcagttag 706981 tgaatccccg atgattaatg tgtgctctgc tgaaaattga ggaatccgtt caaacacgta 707041 attgaaatat tccttcatcg gcttttggaa gccggtgtct tcagaaacga aaatgtcctt 707101 gaagaatgga aataatcctg aatcacggag acgcttatat tgtgtgtgag acacgccgtt 707161 tgtcacgatg tacaaatcaa actgttgctg cagatttgag atgagatcaa atgcaccgtc 707221 aataagctga tgtccttctt caagaaagcg gcggtatttt tgctcaagca aagcgccgtc 707281 cgcttcgtaa ccgtactcct tgagcaaagc ggaaaaacgt gtgtttacga cttcatcccg 707341 tgtcatctta ccttcttcaa aggctctcca gagaccttga ttgatggttt tatactgcgc 707401 cttcatgtca tttgttaaag gaatgttctg atcttcaaac agcaaacgca gggctaaagc 707461 ttctgccgct tgaaaatcaa ggatggtatc atctacatca aataataaag tgcggtatcg 707521 cttcatctgt gtgtctccct ttctcatatg tattcaaagt atagcacata aaaaaaggaa 707581 aaagccggcg ggtgaggcac cgccggctga aaagagatta tttgtttaat aagctgtgtt 707641 ttctcgaata taggaagtaa accagcgttc cgacagcgat ccagatgaca aatgaaagcc 707701 atgtgacgcc gggaaggctg tacatgaacc aaaggcagat gcctgcgctg ataatcggca 707761 caaccggaac gaatggcact ctgaaggacg ctttgatttc aggatgtttc tttcttaaca 707821 caatgacagc aatggaaatg accgtaaacg cggcaagtgt tcccatgttc accagatggg 707881 ccagcgttcc gaggttaata aagccggcga ttcccgctgc aacgatccct gtcagccatg 707941 tgttgcggaa cggggtttta aatgacggat gaacctttgc gaacaatcca ggcagaaggc 708001 cgtctctgct catggcaaat gtcaagcgga cctgtgcgta cagcaaagcg agcatcaccg 708061 tcgtaatccc gataatcgca ccgacagaaa taattccggc aacagcgtcc tgtccgacga 708121 atttcagcgc aaaggataca ggatctccga cattcaattt ggcataaggc atcatgcctg 708181 tcagcacaag cgataccgcg atgtacagaa ccgtacagac ggctagagct gaaataatgc 708241 cgacgggcat gtttttttgc ggatttttca cttcctctga tgcgttagaa accgcgtcaa 708301 acccaaggta cgcgaagaat acagtggcag cgctaagtat gacgcctttc atcccgaatg 708361 gcataaaagg agaccagtta tccggtttca catagccgat gccgacaata atgaacaata 708421 atatgatcgc gattttcatc agtacgatga cgttgttaaa gcgtgtgctt tccttgacgc 708481 ctctgctgac aatcgcagtg atgaggagaa tgatcaccgc agccggaagg ttaaatacgg 708541 cgcccgccat gcttcccggc gctcctgtca gtgcagccgg aatatgaaga ttgaagccgg 708601 caagcagtga ttgaaagtat gaagaccagc cggtggcaac cgccgacagt gcaatgacat 708661 attcaagcat gagatcccat ccgatcaaaa aggcgagcag ctctccaagt gtcacgtatg 708721 agtatgagta cacgcttccc gaaatcggaa tggaagacga aaactcagca taacagaaag 708781 cagccagcgc acaggcgagc cccgctaaaa taaacgatat gatgagggcg ggacctgcac 708841 cggtcgctgc cactgttcct gtaatgacaa aaatccctgt accgatgaca caaccgatac 708901 cgagcaaggt taaatcaaat gcgcttaacg tacgggcaag gctttttgac ttgctctgcg 708961 cactcaatgt ttcaagcggt ttttttctaa ataatgaact catcaaaagt tcctcctaga 709021 aatattcaaa atattctaat cattatatgc agttcttgtt gtattatatt gtcgaaattt 709081 gacgtagtca ataaaatatt tttctgcttt aaatgataga agcgaaacag cgttgtcgta 709141 tcataggata gtaattttta ctaatcgtat attcaatttt atgcaagatg aaccgataga 709201 aaaaatagat tcgcccatat tttgatttgc ggttataaag gagatgctga ccatgtttca 709261 atatgaagag ttgaataaac agtttatcgg cgggaaatgg caggagggca gcagcccaaa 709321 tgtattggaa aacaaaaatc cttatactca aaaaacattc acaacattcc gtaaagcgac 709381 tgctgacgat gtagatgaag cgtatcgggc agcggcgctg gcaaagaaaa aatgggatgc 709441 ggtcaacccg ttcgagaaaa gaaccatttt agaaaaagcc gtcacgtata ttgaagaaaa 709501 tgaagaagcc attatttatt tgattatgga ggagctaggc ggtacaaggc tcaaagcagc 709561 ttttgaaatc ggtcttgtca aaaacatcat aaaagaagcg gcaacgttcc caatccgcat 709621 ggaggggaaa attcttccgt caacaataga tggcaaggaa aacagattat atcgcgtgcc 709681 ggcaggcgtt gtcggtgtca tcagtccgtt taacttccca ttctttttat ctatgaaatc 709741 agtggcgcct gcactcggag ccggcaatgg cgttgtgcta aagccgcatg aggaaacgcc 709801 gatttgcggc ggaacgctga ttgcgaaaat ttttgagaac gcgggaattc cagcggggct 709861 gctgaatgtt gttgtcacag acattgctga aatcggcgac agcttcgttg agcatccagt 709921 gccgcggatc atctcattta ccggttctac gaaagtcggc agctacatcg gacagcttgc 709981 gatgaagcat tttaaaaagc cgcttcttga gcttggcggg aacagcgcct tcatcgtact 710041 tgaggatgca gatatagaat atgcggtcaa tgcggcggtg ttcagccgat ttacacatca 710101 agggcagatt tgcatgtcag ccaaccgcgt gcttgttcat tcttctattt atgacaagtt 710161 ccttgagctg taccaggcaa aagtggaatc gctgaaagtc ggcgacccaa tggaccctga 710221 tacgattatc gggccattaa tcaacagcag acagacggac gggctgatga agactgtaga 710281 gcaagcaatt gaagaaggcg ctgtaccagt gaagcttggc ggatttaacg ggacgatcgt 710341 ggaaccgacg atcttaaaag acgtcaaacc gttcatgagc attgccaagg aagagctgtt 710401 cggaccagtc gtctccttta tgaagtttga ttcagaagac gaagcggtgg atatcgcaaa 710461 cgaaaccccg tttggcttga gcggtgccgt acatacgtca aatcttgagc gcggcgtggc 710521 ttttgcgaaa cgcattgaaa caggcatgat tcacgtcaat gacacgacca tcaatgatga 710581 accgaatgta gccttcggcg gtgaaaagca atcaggcctc ggccgtttaa acggtgagtg 710641 gagcctcgaa gaatttacaa cgctgaaatg gatctcggtc cagcacgaaa aacgcagctt 710701 cccttattaa tgaaaaggag tgaatggaat tgaccataaa tacggaaaaa gaaaccgcag 710761 atattctgga cgcatttatc aaagtagccc cttatttaaa cagcctggtt caggatgata 710821 ttacaatcgg catttatgat acggaaaaac tgctcgtgaa tataccggcc aaaacctttt 710881 cgctgaacgt aaaagccggc gatccgctgc aggaagggga tatcatcaca gatgccatcc 710941 gcagcaatca gaagaagacg agcatggttc cgaaagaatt gttcggcttc ccattgatcg 711001 cgcgtgccat cccgctgcac gacgagaatg gaagagtcat tggaggcgtc ggcctcggaa 711061 cgagccttga ggagtcgtca aagctgcatg atgtcgcgga aagcttatca gctgttgttg 711121 aacaaacagc cgcggctatt tccgacattt ctgaatcaat taacgggttt tcaactcaaa 711181 tgtcgggcat ttcctctcag gcgaaaaaag taagcgaaag cgccggtgaa atcgccgata 711241 tttcagtaac tgttaaaggc atctcggacc aaagcaatct gctcggcttg aacgccgcga 711301 tcgaagcggc aagagcaggg gagtccggaa aaggattctc tgtcgtcgca gatgagatca 711361 gaaagctagc gacgcattca aaagaaaatg tcggccaaat tgaccagatt acgaaaaaaa 711421 tccacagcct gctgaaaggg ctggaggaat ccattgagtc gattaaccag catacagacg 711481 gacaagccgc tgctgttgaa caaatttccg ccacgatgca ggagatttca ggaagcgcgc 711541 agcatcttgc gaaaatggcc gaaaaagcgc ttgaggaaga gtaagagacc ggggacaaac 711601 atccccggtc tttttcttat cctgcatttc catgaaattc gtctgacgtt ttactagttt 711661 tattccagcg gctgatttaa aatgtacaca tgaacttacg tgaggattga taggaaccat 711721 gagcatatta aaagcggaaa atctttataa aacatacgga gataaaacat tatttgacca 711781 tatctccttt catattgaag agaatgagag aatcggatta atcgggccga acggaacagg 711841 aaaatcaacg ctgttgaaag tgattgccgg cttggaatct atcgaagaag gagaaatcac 711901 gaaatccgga agcgtgcagg tcgaatttct tcatcaagac ccggagctgc ctgcggggca 711961 aacagtgctg gagcatatct attccggtga atcggctgtg atgaaaacct tgcgtgaata 712021 tgaaaaagcg ctgtatgaac tggggaaaga tcccgaaaat gaacagcgcc agaaacacct 712081 gctggcagca caagcgaaaa tggacgcgaa caatgcatgg gatgcaaaca ccttggcaaa 712141 aaccgtattg tctaagctgg gcgtcaacga cgtaacaaaa ccggtcaatg agctctcagg 712201 cggccagaaa aaacgggtgg ccattgccaa aaacttaatt cagcccgctg atttgctcat 712261 tttggacgag ccgacaaacc atttggataa tgaaacgatt gagtggcttg aagggtattt 712321 aagccaatat cccggcgccg tcatgctggt gacgcacgat agatatttct taaaccgtgt 712381 caccaaccgc atttatgagc ttgaaagagg cagcctctac acttacaaag gcaactatga 712441 agtgttttta gaaaaacgcg cggaacggga agcgcaggct gagcaaaagg aaacgaagcg 712501 gcaaaacctg ctgcgccgcg aactggcttg gctcagacga ggagcgaaag cccgctccac 712561 aaaacaaaaa gcgagaattg accgggtaga gacgcttaaa gagcagacag gccctcagtc 712621 atcaggttca ctcgattttg ccattggctc gcaccgtctc ggaaaacagg ttattgaagc 712681 ggagaacgtc atgatcgctt atgacggccg catgctcgtc gaccgtttta atgaacttgt 712741 cataccaggt gaacggatcg ggatcatcgg gccgaacggc atcgggaaaa caacgctgtt 712801 aaatgccctt gccggccgtc atacgccgga cggaggcgat attacgatcg gacagacggt 712861 cagaatcggc tactatactc aggatcatag tgaaatgaac ggtgagttaa aagtcattga 712921 ctatataaaa gaaacggcgg aggtcgtaaa aacggcagat ggcgatatga ttacagctga 712981 acaaatgctc gagcgtttcc tcttcccgcg ttcgatgcag cagacgtata tccgcaagct 713041 gtccggcggg gaaaaacgcc gtttatactt gcttcaggtt ctcatgcagg agccgaatgt 713101 cctgtttctc gatgagccga cgaacgattt ggatactgaa acattaagcg ttcttgagga 713161 ttatattgac cagttcccag gcgtcgtcat caccgtatcc catgaccgct atttccttga 713221 ccgcgtcgtc gaccgtttga ttgtatttga aggaaatggt gtcatttccc gctttcaagg 713281 ctcctatagc gactatatgg aggagtcaaa agcgaaaaaa gcggccccaa aaccggcagc 713341 tgaggaaaaa acggctgaag ccgagccgaa gaaaaaacgg aaaaagcttt cttacaaaga 713401 ccagttggaa tgggacggca tcgaagataa aattgcccag ctggaagaaa agcatgaaca 713461 gcttgaagct gacatcgccg cagcaggcag tgattttggc aaaatccaag agctgatggc 713521 cgagcaggcg aaaacggcgg aagagcttga ggctgcgatg gaccgctgga cagaattgtc 713581 cctcatgatc gaagaactgg aaagctaaaa agcgtggccg cagcaggccg cgcttttttt 713641 cacataatgg acaaaaacga accggcctgc ttatgttagg ataaagttgt gtgtcagcgg 713701 cacatggaaa actaacggag atgatgaagt atgacatggg cgatcgtgat gttaattctc 713761 atgagtctgg tgaaaatcgt attaacctgt cttcctacag gcgtcataga atggctgctc 713821 ggcaaatttg aagtgcacgc caagctgagt gacgaaaatg cgagtctctc tctagatgga 713881 aaacgcctcg agggtgcaga gaagcagaaa gtgattgatc aatttaacga agctatcttc 713941 ctggaaaaat attatatcta tccaggtgat gaagagcgtt atttacatcc ggaaaacggc 714001 ggcacgcctc tggtgataga tacaaaaaaa ggaaaaaaag acgtgaagct gttcgtgtac 714061 cgctacgacg accatatcga cgtcgtgaaa cagtacaaga agaaagtgat cgcgtatcga 714121 gtgctttctg aaagccttca aaaagagtct ctgtcagtgg cgggaagttt agcttaaaca 714181 ggaaagtgaa agacgggtgc tgtatgctgc tcgtcttttt tattgttttt taaaacttaa 714241 cgtttacgtt aaggttcaaa aggtgtataa tggtaacaga aacggcgaag ggggatttac 714301 cttggaatgg atgaagattg atcaagtggc caaaagaagc gggctgacaa agcggaccat 714361 ccggttttat gaagaaatcg gcttgattcc ggcgccgaaa cggacagacg gcggtgtaag 714421 gctttattca gaggatgata tggaggagct tgagaaagtc atcagcacaa aagaggtgct 714481 cggtttttcc cttcaggagc ttcagcattt catggaaacc agccgccagc tagagttaaa 714541 caaagagggg tatttgttgt cactggatcc taaggaacgg aaagaaaaac tggaggaaat 714601 tcaggaaacc ctgaatcacc agctggattt gattgatgag aaaatccgca cattccaaag 714661 ctttaaagaa cgcctgcagg gcatgaaagg caaagcggaa cgcgccattc aatcaatcga 714721 atgaaaagtt tgttaaacgc tatttttgta gcgtttcttt taatggaata aagatggagg 714781 ttaggtcaaa tggataagac aacacaagtg aatcagaaaa cgggtttgct cagccagcca 714841 aaagcggtat gggctgtcgc gtttgcctgt gtgatttctt ttatgggaat cgggctggtc 714901 gatccaattc ttccggccat tgccgcacaa ttgcatgctt cacctagtga agtatcactc 714961 ttgtttacaa gttatttgct tgtaaccgga tttatgatgt ttttctcagg agccatttcc 715021 agccgcatcg gcgcgaaatg gacattaatt ctcggactta tttttattat tgtgtttgcg 715081 gggcttggcg gcagctcaag ctcaatcgct cagttagtcg gctatcgcgg cggctgggga 715141 ttagggaatg ctttgtttat ttcaacagcg cttgcggtca tcgttggcgt gtcagtcggc 715201 ggcagcgccc aagcgattat tttgtatgag gccgcgctcg gtctcgggat ttctgtcggg 715261 ccgcttgcag gcggagagct cggaagcatt tcatggcgcg caccgttttt tggagtatct 715321 gtcctgatgt ttattgcgtt aatcgcgatt tctttcatgc ttccgaagct gccgaaaccg 715381 gcgaaacgcg tcggtgtgtt tgatgcgatg aaggcactca aatataaagg cctgctgaca 715441 atggcggtat cggcattcct atacaacttt ggatttttta ttttgctagc ttattctccg 715501 ttcgtactgg atttagatga acacggtctt ggatatgtct tcttcggctg gggccttctg 715561 ctggcgatta cgtcagtctt tacggcgccg ctcgtgcaca aagcgctggg cacagtgcgt 715621 tcgctagtcg ttctctttat cgcctttgcg gccattctcg ttattatggg gatctggaca 715681 gaccatcaga ctttgattat tacatgtatc gttgtcgctg gtgctgtcct cggtatggtg 715741 aatacgatca tgacaaccgc tgtgatgggt tctgcgccgg ttgaacgttc aatcgcgtct 715801 tcagcctaca gctcagtccg cttcatcggc ggcgcgctcg ccccgtggat tgcaggaatg 715861 ctgtcagaac actttactgc aagcacacca tatacagtag gcggaatcgt cgtttttgtc 715921 ggcatgcttg tccttctcat gggacgtaaa catcttgctg gaattaaggc ggggcattaa 715981 taacgaaaga cactgcgcat atgcagtgtc tttttattcg ttataatgca tcataatcga 716041 attggtgcag gaaaggacaa cctttatgac acaattttac tattttccgg ctgaaaactc 716101 cctttagaaa ccggtttttt cggtcagcaa gaacggcgtt cgcggaaagg gcatccgctt 716161 cggtcaggca ttgatgcggc tgggatttat cttgcagaag ctgagaatgt gtccgttcat 716221 ttacgattgc catttcagtg atggttcatg ctgtagaggg gacgtttgcc atggataagg 716281 caaaacctga cgaatatgat cagaaatgtt tagaaacgct ctatcaatac atacacagcg 716341 tcatgaaaaa cagcttttct cggtcgagtg gtttaccgct tgggaagatg aggaggattt 716401 tgagctgtct gccaaaagag agctgacact tgatgaattc acatctccat tgcagctcat 716461 tttaaaagac agagagcttt tgagaatcgt tcagaaaaaa tggcagtaaa aaacccgccc 716521 tttagcaggc gggttttttt ataaattaaa gcactttcgt cgtccaagac tcgcagttcc 716581 acgtttctgt cgcaatatcc atataaaagt ctggctcgtg ggaaatgagc agaatggagc 716641 ctttatattc tttcagggcg cgcttgagct cttccttggc atcggcatcc aagtggtttg 716701 tcggctcatc gagcaccagc aggtttgttt ctgagttgat tagcttgcac aatctgactt 716761 tcgctttttc gcctccgctt aatacggaga cgcggctttc gatatgcttt gtcgtcagcc 716821 cgcattttgc cagagcggca cggatttcat actgcgtata agaagggaat tcgctccata 716881 cttcttcgat gcacgtattg ttgtttgttt ccttgacctc ttgctcgaaa tagccggtat 716941 agatgtgctc accgcgttca acagagcctt cgagcggctg gatttcacca agcaaacttt 717001 tcagcaatgt cgtttttccg atcccattcg cgccgtaaag ggcgattttt tggccgcgct 717061 ccatgcggag gttgagcgga cgggacagcg gggaatcgta accgatcacg agatccttcg 717121 tttcaaaaat cagcttgcct gacgttctcg ccggcttaaa gtggaattcc ggctttggct 717181 tttctgccgc aagctcgatc atatccatct tatcgagttt cttttggcgg gacatcgcca 717241 tgtttctcgt gctgacacgc gctttgttgc gggcgacgaa atccttcagc tccgcgactt 717301 cctgctgctg ctttttgtag gccgcttcaa gctgctgttt tttcacctcg tagacttcca 717361 taaactgatg gtagtcgccg acataacgtg tcagctcttg attttcaacg tgataaatca 717421 ggttgatgac actattcaag aacggaatat cgtgggaaat caggatgaac gcgttctcgt 717481 attcctgcag gtagcgtttc agccattcaa tatgctgttc atcaagatag ttggtcggct 717541 catcgagaag cagaatttcc ggcttttcaa ggagaagctt agcgagaagg acctttgtgc 717601 gctgtccgcc gctcaaatcg gtgacatctc gctctaaacc gatatcgctc aaaccgagac 717661 cgcgggcgat ttcttccacc ttggaatcaa tgacataaaa atcattgttt gtcagcgcgt 717721 cttgaatgac gccgacttct tcaagcagct tctcgagctc gtcgggatca gcctcgccca 717781 ttttgttgta aatctcgttc atttcctctt ccatcgcaaa taaataatgg aatgcgtctt 717841 tcaggacgtc gcgaatggat tttccttttt ccagcacggt atgctgatca aggtatccga 717901 cacggacatt ttttgaccat tcgacttttc cctcatcagg ttcaagcttt ccggtaataa 717961 tattcatgaa ggttgatttt ccttcaccgt ttgcgccgat caagccgacg tgctcgcctt 718021 ttaacaggcg gaaggaaacg ttattaaaaa tggcccggtc cccgaaaccg tggcttaaat 718081 cctttacaga taaaatactc atgtttacac ctctatcgtt atcaaacacg cacaatcggc 718141 gtgtaatatt cacccttttg attataaagg aggattcgga atgttgaaag gtataggaaa 718201 gaaaaagaaa aattgcgttc cgggcgaggt tttgagatac tatggaatag atttcaggaa 718261 ttgaggagaa caaaatgacg caaacttggc catttttaca taatgcacaa tcatttatac 718321 aagagaattg gaatgcttcc ggctttcaaa agccaacccc tgttcaggag caggcagccc 718381 agctgatcat ggacggaaag gatgtcattg cagaatcgcc gacaggcaca gggaagacgc 718441 tggcgtatgc gctgccggtc ttggagcgga tcaaaccaga gcaaaagcat ccgcaggcgg 718501 tgattttagc gccttcccgt gagctggtca tgcagatttt tcaggtgatt caggattgga 718561 aagcgggctc agagctgcgc gcggcttcct taatcggcgg ggcgaatgtg aagaaacagg 718621 tcgaaaagct gaagaaacat ccgcatatca tcgtcggcac gccaggcagg gtgtttgaac 718681 tgattaaagc gaagaaactc aaaatgcatg aagtgaaaac gatcgtgctt gatgaaacgg 718741 atcagctcgt cctgccggag catcgcgaaa cgatgaagca aatcattaaa acaacattaa 718801 gagaccgcca gcttctatgt ttttctgcca cgctcaaaaa ggaaacagag gacgtgctcc 718861 gcgaattggc gcaagagcct gaggtgttga aggtgcagcg aagcaaggcg gaggcaggga 718921 aagtgaagca tcaatacctg atttgcgacc agcgcgacaa agtgaagctg ctgcaaaagc 718981 tgtcaaggct tgaaggcatg caggcactcg tatttgtgag agacattggc aacctgagtg 719041 tatatgcgga aaaactggca tatcaccacg ttgaactcgg cgttttgcac agtgaagcga 719101 aaaaaatgga gcgagcgaaa atcattgcca cattcgaaga cggagagttt cctcttttat 719161 tggcgactga cattgccgca cgcggtttag atattgaaaa cctgccatac gtgattcatg 719221 ctgatattcc agatgaagat ggctatgtcc acagatcagg acgaacaggc cgggccggaa 719281 aagaaggcaa cgtgctgagc cttgtgacaa aattggagga atctaagctg aaaaaaatgg 719341 cgaagaagct tggtgttgag ctgagtgaag ctgtgtatgc aggcggaaaa ctgaagacga 719401 aataaaaaga agggcgaaga gccctttttt tgttgtaaaa taatagaaaa gattttgcgc 719461 ggaggtggga aaatggcttc aatagacagg tttcaagtaa tgcaggagcc agagctgaaa 719521 atccttgaac actggtttga gaatgaggat accagacgga gaatggatgg gatgctgcta 719581 ttagatgagt ggtatgcacg agtaaataaa gataaacacg atactgtcat catggcgtat 719641 gatggacagc tgccggcagg gatggtcgtt attgagttcg gagaggagcg gacatatatt 719701 ggattgatcg tcaatccttt gtaccggctt aaagggtatg gaaaacagat actgcaaaag 719761 ctgatgaccg aacctgattt tactagcgtg cgagaatggg tggcatgcat tgaagaagac 719821 aatcgaatca gtttagcttg ctttcaagca gcaggattca ctttagaaga cacggaacct 719881 gatgaagatg gttttcttac gctgattctt cgcaactgat ctcatcgaaa cacaaaagga 719941 gggcaaaaag ccctcccgtt ttcatcttca ttcagctcgg atcactgacc ttgatcagct 720001 gtttcccttt attttctccc ttaaataaac cgagaaacgc gtcaggaatg ttttcgaagc 720061 cttctgtgat ggtttcctcg taatggagtt taccagcctt cagccattct gccagctgtt 720121 ttgctccctc agaaaaacga tcggagtagt cgcttacgat aaagccttgc atcagcgact 720181 tcgttttaat gagttttgat tggacacgag ggcccatgtc atctgcttcg ctttctgcgt 720241 tataggaaga aatggcgccg cacaccggaa tgcgggcaaa ttcattgagc agattcatca 720301 ccgcgtctga aatcggtccg ccgacattgt caaaatacac atcgacaccg tcaggacaag 720361 cgttttgaag cgctttttgg atatcatccg ctgttttgta attgatggct tcgtcaaact 720421 gaagctcctg ttttaaatag tcgatttttt catcagagcc cgcgatgccg acgactcgcg 720481 cgcctttgat tttggcaatt tgcccgactg ttgaaccgac ggctccggca gctcctgaga 720541 caaccacggt ttcgccttcc ttcgggcgtc cgatgtccag caatccgaag tatgctgtta 720601 agccggtcat tcccaaaatg ccgagatagg ccgaagcggg agcaaggctt gtatcaattt 720661 ttcgcaaggc agactcgctc acagcggaaa attcctgcca gctgagattt ccgatgacga 720721 tatcgccttt tttcagatga ttcccgtctg acacaacttc agcgataacc cctccagaaa 720781 gcgctttatc caaggcgaac ggctcaacat atgacttcgt atcctgcata cggccgcgca 720841 tataagggtc aaccgataca taaagcgttt tgacaagcac ttccccttgc ttgggttcag 720901 gaaccggaat ggtttcaaag cgaaagtctt catgaacagg aataccttgt ggacgtcttg 720961 ctaattgaat ttgctgctga gatgctgtca ttttcatcct cctatcactt ggttgacacc 721021 actgtaacat ggacaggaga ggaaatacaa aaggtaagct ggcatacaaa aaaggttata 721081 gatgagctta tgctttctac aagctctttt gttttaaaag ttctctttag tcatttatca 721141 ttattagaaa acagaacaga aaaagagctc ctgtacacct agctaagatt ggctagtgtg 721201 tatgtcgatt ctttttcata ttcttgcaag catctgcgag ggggagctta gtcgttcaca 721261 ttttgctttc gcatcaatct gcaatagcaa agtctatgcg atttttttac atcagcaaag 721321 atttgttcaa ttttttcctt ttatgccgag tttttctgaa acagataatt gatggtactc 721381 aaccattttc ttttggtcaa taaagtaatg tttacttatt aattaaacac gcgaaaaagc 721441 aaacgaaaac ataattaaat tttatatatt tattaaaagc ttatatgttt atttaccttt 721501 tttttgaatt gtaattgaga aaatccatat attgcggaca ctaataaaag aatacctgct 721561 gaaacataaa ctaaacgaac tccaaggaaa tctgaaatag cccctatagc cagaattgaa 721621 aacataaaaa tgaactgtac taaagaagac cttgcagaca ttatattaat tcgagtttgc 721681 tcggttgtta tgttctgaat aagtgtttct tgtgtaagat ctcttaatat ataagccggc 721741 cccataaaga gaaccaaaat tagagctaag tatgaattac ttataaaacc atatattaaa 721801 gttaaacttc catatgagac agcgccaatt aacataaaat taattaactt attttgaaat 721861 ctctccgaca gcttatatat tataaatccc cctatcatcg aacctaaata atatgctcca 721921 ttaataaatc cccaccatga ttctccttta tgcaagactt cgttaacgaa agctaaagag 721981 acagatccta tccaaatcat tcctgcccat gactcaatta aatccataat aataattgtt 722041 ctaagtttct tttggctaaa taaataccgc caaccactta ctatactctt attgggagaa 722101 tttttttcac gtatgacaga attagcgtgg ccatgtggta gacaaaataa aagagaaaga 722161 agagatgtaa acaacaaaaa gatagtaagt ataatggtat atccctcacc taaaaatgca 722221 attatgagac cacctaaaga ccagcctaca aattgaaaag tttggtccac tgtagataat 722281 aatccatttg cttttactct tctatcagga gagattattt cccctataat tgcacttttt 722341 aaaggtgaga accatccatt aaaaaaggaa atacagctaa taataataaa gactaaaatg 722401 agagtttgat tagagtaagt tcttaataaa gcatagaaca aacatattaa taacagcatt 722461 tgtatcaatt gagaaataat tattgtaaga ggcagtttta atcgaattgt tattaacggt 722521 aatatagcac ttccaaaaat acgaaaaata atacttatta atgtcaccat agaggcgatg 722581 gttgtcgaat tggtcatttt aaacaaaaac gaaatcacta ccatagtata tagagaaaaa 722641 cctaaatttg tagtggtctg gctaaataaa atagaataat aacctttact catatgtatc 722701 ctcccttgga ataatttttc tcggtaaaga gcttaaacat atttaaacac cttaaaacaa 722761 caaaagtaaa gaaaaaattt ccttgtaaac tatttacttt tattctattt attgttattg 722821 tttatttaag ttctctgact attctatcaa tattcaggga accacatatc ttattaaagg 722881 ggggaaaacc atgagaaaat taagaaaaaa ctggagaaaa tcgattgtta gcccggttct 722941 ttatactaat gaaaaatggt aaacacttag ggaatagcat ttaatgctat tccttatttc 723001 aacaaacaaa tcgggaggtt atcgtaattt gactctatta atgcaagatc ataaatcaat 723061 ttacaataaa gatatagaaa tattaattga agttgaagaa cttattactt ctgttccaga 723121 aaataaaaaa aatgatttta agagtttaat cgataataga attatgactc tactaaataa 723181 aattcaacac cctgtagcag cggaaaatgt gtttgggatg tgtattgctt atccgaatac 723241 ttacataagg tatagattaa ttgatttcgt tgaaaaatgg gtaccttatt tctctgctgt 723301 agaaactata atcaatctaa cccaggatcc ggatgattta gtttctttta aagctatgga 723361 tgtctgtgca aatcataaaa ttgaagaatc tgtagcatat ttgtcttcga ttattgatga 723421 tgtccgggag agtataagct accctaaaaa acctgtggga ttaggggccc aaaaagtatt 723481 aagtacatta ttagatatat tcggtgttga aaaacatgaa gagctagtaa tgctaaaaaa 723541 ttattttgat caaaatggta tacttcctaa taactttgac tttgaagaaa aaattcctca 723601 aagtctaata gaggaattcg aaaaaacaga agaagatggg atgattttaa ttccgggtgg 723661 cttttttgaa ttcggtttaa atgaaaatga aattcctgac aaaacattta attggaaaga 723721 tgctgttcct agacaaaaag tatggttacc tccatttttt atcgataagt atcctgttac 723781 aaataaagat tatgatatct ttaccgagtt catagaggaa aatgggcata tattctgtca 723841 tcctaatgaa ccgcagaata aacaacatag aagaaataca tattgggatg ataggtattt 723901 agataatcat cccgttacag gtatagattt ttatgatgca tttgcttacg caagatataa 723961 ggggaaagaa ttgccaaccg agtttcaatg ggaaaaagct gctcgaggcg aaaagggtaa 724021 tgtctggcct tggggagata aatttgatcc tgcaaaggtt caatatgctg gaagtcttta 724081 taatgaaccc attacttctt taaagtcctg gagagaaaat ttattaaaag ctcatgctga 724141 taaagaatta aatcatttaa caagtgatat ttttgaacaa aatggtgaaa gtccctatgg 724201 agtatgcggt atgatcggcg gaacatggga gtggactaga agtgagctta aaacaaagag 724261 agctttccac cctatttttg agaatgtacc atttaatagt gttaactcat ttgccgttct 724321 taaaggagga tcattcttct ctcatccagg cttaatgttc ccttctttta gagcaaaaga 724381 tattcctttc tgtcgacaca atgaaatggg gattagatgc gtaaagaata ttccagtata 724441 taaaattaga gaatcaatta atgggccaat tactaataaa gcaatttatt aatcattcta 724501 ggttagagac ttgataaaag tatactaaca ttgtgtagta atgttcagct tgtagaaaaa 724561 acaatgtttt ttctacaaga ttttatttta aatgcttttc aaaattatca gggattgaga 724621 atcagaaaaa gagccattaa gctcgatctt agctaggtat tacgatcttc tgtatattat 724681 tgtgagaaat atagaagatt cagttagtta gcatttcgat tttaagctga gcctgcaata 724741 gcaaagcatc tgttttgatt attctttttc tgatacataa gctaattttg tcgcttttct 724801 tttttgtctt ttcacgcatt tcgaggatga cttactataa ttctttcagc ttttctatgt 724861 gttaagattc gaatagatga aataacttta acaagttggt caataagaac agatttaact 724921 ttatgttaaa agagtatctc gtatagaaca taagaagaat gacgagtttt ttaagattat 724981 catcaattat gtgagaataa aatattataa gggaaaatga aggctgtcac gtttctcgac 725041 agccctaggg aattcctctc cttttcattt cgcccgtaat ttcgggcaca gtcccgtcgg 725101 caggcacatt ggcttctggt cgatcgggct tctcatgatg cagcattcca agccgaagac 725161 ttcacggaaa aatggctggg tgaacacatc ttccggtgtt ccggcgttgt atatttttcc 725221 gtccagcaca ctgatcagat agtcagcata ttgagcggct tggtttaaat catggagcac 725281 catgacaacg gtgcggccat ggtcgcggtt cagctttttc agcagttcaa gcacttcaat 725341 ctgatgtgag atgtctaaat acgtggtcgg ctcatcaagc aaaagcaaat cagtgccttg 725401 cgcaagtgcc atggaaatcc aggctctttg tctttggccg cctgagaggg catcaagtgt 725461 ccgatccttc agttcaatca tgcccgttgc ttccagcgcc cactctacca tgtcatgatc 725521 ctcttgggta tgcttggata acagcttttt gtgaggatgt ctgccaaaat agcataattc 725581 ctctaccgtc aatccttcag gagcctgagg agattgtgga agaatggcca gtttttttgc 725641 gacttctttt gatggctggc ggtggatgtc ttttccttct agtagcactg taccgctttt 725701 tggggccatc agcctggcga gcgatttgag gattgttgat ttaccgcagc cattagcgcc 725761 gatgagcgca gtgatttttc cttcttctat ctttaagtcg actccgtcaa taatcactgt 725821 actgtcatat gaaagagtga gctggtctgc agccagtttt cccatggtat cctctcccta 725881 ctgtttcctc gcttcgaatt tcaataaata taagaaataa ggcgcgccga tcacggctgt 725941 cagtattccg gcaggtattt caaccggagg catgatgccg cgccctaacg tatctgcaat 726001 taataatata atagcaccaa tcaatgccga tgcaggcagt aaatatttag ctttttctcc 726061 ggtaagccgt ctggcgatat gcggagcaag caagccgata aaaccgattg agccgacgac 726121 ggctacacag cttcccgcca gcgccaccgc ggtgaaaatc aggatgaatc tcagccggtt 726181 tgcgttttct ccgagaccct gtgcaagctc atccccgagt gacataagat ccagcttcgg 726241 tatgagtatg cagacgatcg gaaaaagaat caaaagccat ggcgcaagca gcttgacttc 726301 ttcccagttt cttccccaga ggcttcctgt cagccaaatg agtgcagcat tcacgtcgcc 726361 tggaaacttg accatcatat attgcattcc ggcgtggcag accgcgccta aagcaatgcc 726421 tgataaagcc agtgaagagg gctgaatgct cttttttcgg gctatcatta ataatagtac 726481 agcaataatg gcggctccgg caaatgcgga gaacggaagc acgtataccg gcgactcagg 726541 aaagatgaga atcacagcca tcgccgcaag tccggagcct tttgaaatgc cgacaacgtc 726601 cggggaagcg agcggatttc ggatcacacc ctgtaaaatc gctccggcag cggcaagtcc 726661 agcacctgcc aaaatcgcta atataatgcg gggaaggcga tattgctgga tgataaattc 726721 aaaggaatga tccagtccca gcagattcgt cactaccgca tcaggtgaaa tgtataatgc 726781 accgattcca atgctgatga cggacagaac gattaaaatc acggccaata tgagtatcgc 726841 cagtaagggg cgtttttgtt ttctggttgt tttcttcatt tcaggtttcg ccctttcctt 726901 gccaaatata agaaaaacgg cgttccgata atcgcggtga caatgccgac cggtgattca 726961 taaggaaatg caatccatct ggccagaaca tctgcgtaca ccagcaaaat ggcaccgaac 727021 agtgccgaaa acggaagcac gtattgataa tgttctccga tcagcttgcg gacaatatgc 727081 gggacgagca gcccgacaaa gccaatcggc ccggcgacgg ctacggaagc gccggaaaga 727141 attaaaataa tcaaactgat cagaatcctg atgccgttca tattttgtcc aagccctttt 727201 gctgtttcgt ctccgagacc gagaacagaa acagaaccgg aaaatacgag ggcaagcccg 727261 atgccaatga cagaaaaagg agcgatggtt atgacgtcct gccagttgct gccgtcgatt 727321 gcgcctgtca tccagtacag aacatcctca cctgactcat ttaaaataat gatggcctgt 727381 gtcatagagg agaggaacaa gtgcacggcc attcctgaca gcgccagctt gacaggcgtc 727441 attccgccgg atgaggcaat catatacaca atcgcgccgc ctgctgccgc acccgcaaaa 727501 gcgaatataa cagatgaata gggcgatgcc ggcagaatga cgagagaagc aacaacaaaa 727561 agcgatgcac ccgcattcac accgaaaatt tggggtgaag ccagaggatt tctggtcata 727621 gcctgcatca gcgcccctgc tacagctagg ctggcgccga caaaaacgcc gattaatgtg 727681 cggggaaggc gaagagtaga gatgatgagc tgttcctttg aaccgtccca tacaaaaaga 727741 tatttcaatg aatctatgat gctgatgtct gaggctccta ctgaaagatt cagcccaagc 727801 ccaaatataa aaataatcag tgcaatgata aacatcatca gtcttgatga tgagcgccgt 727861 ttggctgaat gatacaacag tctcacttcc ttactgcgtc tggttgcaaa aacgaagaag 727921 caaggattcc cctcgcttct catttgtcct atttattata cactttttta agcacatctt 727981 tggcgcttgt ttcactagac ttgatgcctc tgaatcttgt ccaagtgtca cggtccgcat 728041 catagacttg tccatttttc accgctttga gatttttcca gagcgggttc gttttccact 728101 catctacaat ggttttgcct tcgttggctg agatgaacaa aatatcagga tcgattttgc 728161 tcaattgctc aaggctgacc tcttgatagg cgttatctga cttcacagcg tgtgtaaagc 728221 ctagcatttt aaagatttct ccgtcatagg atgatgatgt atgaagctgg aaggaatccg 728281 ctcttgcaac gccgagaacg atgttgcggt tttcatcttt cggaagttcg gcttttagat 728341 cgttgatgac ttttttgtgc tcggcaagct tttcttttcc ttcatcttct ttatttaatg 728401 ctttagcaat ggtcgtaaag ctgtcgatcg tttcgtcata tgtcgcttca cggcttttta 728461 attcaatcgt cggggcgatt tttttcagct gtttataaat gtttttatgg cgctcagcgt 728521 cagcgatgat taaatcaggc ttcaaggaac tgatgacctc aagattgggt tcgctgcgtg 728581 tgcctacaga tgtgtaatca atggagctgc cgacaagctt tttaatcata tcttttttgt 728641 tgtcatctgc gatgcccacc ggcgtaatgc cgagattgtg aacggcatcc aagaatgaaa 728701 gctcaagcac aaccacccgc ttaggtgtgc cgcttactgt cgtttttcct tcttcgtcat 728761 ggatcactct ggaatcctta gactcgcttt tgccgcttcc gttgttattc tggcttgatg 728821 aacagccgga tacaatgagg caggcgagca ataaaacact catgatggca atcaacttgt 728881 tagaataggt gcgcatgtca ttcttccttt tttcagattt agtaatgaga atcattatca 728941 catgtaacac tataatagca tggcttatca tgtcaatatt tttttagtaa agaaagctgc 729001 gtttttactg ctttctcatg aaagcatcat cagacacaaa taagtggtat gcagcgttac 729061 cgtgtcttcg agacaaaaac gcatgggcgt tggctttaga ggtttcgaac atatcagcag 729121 tgacataagg aaggagagtg ctgagataac cggacaattt cttttctatt tcatctgtta 729181 gtgcaaattc aatgtcgccg atattcatga taatcgagaa aacaaagtcg atatcgatat 729241 gaaaatgttc ctcggcaaaa accgcaagct cgtgaattcc tggtgaacat ccggcacgct 729301 tatggaaaat ctgtttgact aaatcactca caatccaagc attgtattgc tgttctggtg 729361 aaaagtattg cattagacat acctcctgct cgtacggata aaggcagcgt ttcatggtcg 729421 tgtgctccgt gcagcggctt ctccttaatt ttgatttttc tgaaaatagg tcccgttcct 729481 atcactttac catggacgga aaacaaatag ctactaccat tcctcctgtt tttctcttca 729541 atgttctgga atctgtttca ggtacagacg atcgggtatg aaagaaatat agaaaacatg 729601 aaggaggaat atcgacatga aaccagttgt aaaagagtat acaaatgacg aacagctcat 729661 gaaagatgta gaggaattgc agaaaatggg tgttgcgaaa gaggatgtat acgtcttagc 729721 tcacgacgat gacagaacgg aacgcctggc tgacaacacg aacgccaaca cgatcggagc 729781 caaagaaaca ggtttcaagc acgcggtggg aaatatcttc aataaaaaag gagacgagct 729841 ccgcaataaa attcacgaaa tcggtttttc tgaagatgaa gccgctcaat ttgaaaaacg 729901 cttagatgaa ggaaaagtgc ttctctttgt gacagataac gaaaaagtga aagcttgggc 729961 ataaagcaag gaaaaaacca aaaggccaat gtcggccttt tggttttttt gcggtctttg 730021 cggtgggatt ttgcagaatg ccgcaatagg atagcggaac attttcggtt ctgaatgtcc 730081 ctcaatttgc tattatattt ttgtgataaa ttggaataaa atctcacaaa atagaaaatg 730141 ggggtacata gtggatgaaa aaagtgatgt tagctacggc tttgttttta ggattgactc 730201 cagctggcgc gaacgcagct gatttaggcc accagacgtt gggatccaat gatggctggg 730261 gcgcgtactc gaccggcacg acaggcggat caaaagcatc ctcctcaaat gtgtataccg 730321 tcagcaacag aaaccagctt gtctcggcat tagggaagga aacgaacaca acgccaaaaa 730381 tcatttatat caagggaacg attgacatga acgtggatga caatctgaag ccgcttggcc 730441 taaatgacta taaagatccg gagtatgatt tggacaaata tttgaaagcc tatgatccta 730501 gcacatgggg caaaaaagag ccgtcgggaa cacaagaaga agcgagagca cgctctcaga 730561 aaaaccaaaa agcacgggtc atggtggata tccctgcaaa cacgacgatc gtcggttcag 730621 ggactaacgc taaagtcgtg ggaggaaact tccaaatcaa gagtgataac gtcattattc 730681 gcaacattga attccaggat gcctatgact attttccgca atgggatccg actgacggaa 730741 gctcagggaa ctggaactca caatacgaca acatcacgat aaacggcggc acacacatct 730801 ggattgatca ctgtacattt aatgacggtt cgcgtccgga cagcacatca ccgaaatatt 730861 atggaagaaa atatcagcac catgacggcc aaacggatgc ttccaacggt gctaactata 730921 tcacgatgtc ctacaactat tatcacgatc atgataaaag ctccattttc ggatcaagtg 730981 acagcaaaac ctccgatgac ggcaaattaa aaattacgct gcatcataac cgctataaaa 731041 atattgtcca gcgcgcgccg agagtccgct tcgggcaagt gcacgtatac aacaactatt 731101 atgaaggaag cacaagctct tcaagttatc cttttagcta tgcatgggga atcggaaagt 731161 catctaaaat ctatgcccaa aacaatgtca ttgacgtacc gggactgtca gctgctaaaa 731221 cgatcagcgt attcagcggg ggaacggctt tatatgactc cggcacgttg ctgaacggca 731281 cacagatcaa cgcatcggct gcaaacgggc tgagctcttc tgtcggctgg acgccgtctc 731341 tgcatggatc gattgatgct tctgctaatg tgaaatcaaa tgttataaat caagcgggtg 731401 cgggtaaatt aaattaagaa agtgaaaaac acaaagggtg ctaacctttg tgttttttaa 731461 ttaattaaaa tgtttattaa cttagttaag gagtagaatg gaaaagggga tcggaaaaca 731521 agtatatagg aggagaccta tttatggctt cagaaaaaga cgcaggaaaa cagtcagcag 731581 taaagcttgt tccattgctt attactgtcg ctgtgggact aatcatctgg tttattcccg 731641 ctccgtccgg acttgaacct aaagcttggc atttgtttgc gatttttgtc gcaacaatta 731701 tcggctttat ctccaagccc ttgccaatgg gtgcaattgc aatttttgca ttggcggtta 731761 ctgcactaac tggaacacta tcaattgagg atacattaag cggattcggg aataagacca 731821 tttggcttat cgttatcgca ttctttattt cccggggatt tatcaaaacc ggtctcggtg 731881 cgagaatttc gtatgtattc gttcagaaat tcggaaaaaa aacccttgga ctttcttatt 731941 cactgctatt cagtgattta atactttcac ctgctattcc aagtaatacg gcgcgtgcag 732001 gaggcattat atttcctatt atcagatcat tatccgaaac attcggatca agcccggcaa 732061 atggaacaga gagaaaaatc ggtgcattct tattaaaaac cggttttcag gggaatctga 732121 tcacatctgc tatgttcctg acagcgatgg cggcgaaccc gctgattgcc aagctggccc 732181 atgatgtcgc aggggtggac ttaacatgga caagctgggc aattgccgcg attgtaccgg 732241 gacttgtaag cttaatcatc acgccgcttg tgatttacaa actgtatccg ccggaaatca 732301 aagaaacacc ggatgcggcg aaaatcgcaa cagaaaaact gaaagaaatg ggaccgttca 732361 aaaaatcgga gctttccatg gttatcgtgt ttcttttggt gcttgtgctg tggatttttg 732421 gcggcagctt caacatcgac gctaccacaa ccgcattgat cggtttggcc gttctcttat 732481 tatcacaagt tctgacttgg gatgatatca agaaagaaca gggcgcttgg gatacgctca 732541 cttggtttgc ggcgcttgtc atgctcgcca acttcttgaa tgaattaggc atggtgtctt 732601 ggttcagtaa tgccatgaaa tcatccgtat cagggttctc ttggattgtg gcattcatca 732661 ttttaattgt tgtgtattat tactctcact atttctttgc aagtgcgaca gcccacatca 732721 gtgcgatgta ttcagcattt ttggctgtcg tcgtggcagc gggcgcaccg ccgcttttag 732781 cagcgctgag cctcgcgttc atcagcaacc tgttcgggtc aacgactcac tacggttctg 732841 gagcggctcc ggtcttcttc ggagcaggct acatcccgca aggcaaatgg tggtccatcg 732901 gatttatcct gtcgattgtt catatcatcg tatggcttgt gatcggcgga ttatggtgga 732961 aagtactagg aatatggtag aaagaaaaag gcagacgcgg tctgcctttt tttattttca 733021 ctccttcgta agaaaatgga ttttgaaaaa tgagaaaatt ccctgtgaaa aatggtatga 733081 tctaggtaga aaggacggct ggtgctgtgg tgaaaaagcg gttccatttt tccctgcaaa 733141 caaaaataat ggggctgatt gcggctctgc tggtctttgt cattggtgtg ctgaccatta 733201 cgttagccgt tcagcataca cagggagaac ggagacaggc agagcagctg gcggttcaaa 733261 cggcgagaac catttcctat atgccgccgg ttaaagagct cattgagaga aaagacggac 733321 atgcggctca gacgcaagag gtcattgaac aaatgaaaga acagactggt gcgtttgcca 733381 tttatgtttt gaacgaaaaa ggagacattc gcagcgcctc tggaaaaagc ggattaaaga 733441 aactggagcg cagcagagaa attttgtttg gcggttcgca tgtttctgaa acaaaagcgg 733501 atggacgaag agtgatcaga gggagcgcgc cgattataaa agaacagaag ggatacagcc 733561 aagtgatcgg cagcgtgtct gttgattttc tgcaaacgga gacagagcaa agcatcaaaa 733621 agcatttgag aaatttgagt gtgattgctg tgcttgtact gctgctcgga tttattggcg 733681 ccgccgtgct ggcgaaaagc atcagaaagg atacgctcgg gcttgaaccg catgagatcg 733741 cggctctata tcgtgagagg aacgcaatgc ttttcgcgat tcgagaaggg attattgcca 733801 ccaatcgtga aggcgtcgtc accatgatga acgtatcggc ggccgagatg ctgaagctgc 733861 ccgagcctgt gatccatctt cctatagatg acgtcatgcc gggagcaggg ctgatgtctg 733921 tgcttgaaaa aggagaaatg ctgccgaacc aggaagtaag cgtcaacgat caagtgttta 733981 ttatcaatac gaaagtgatg aatcaaggcg ggcaggcgta tgggattgtc gtcagcttca 734041 gggagaaaac agagctgaag aagctgatcg acacattgac agaggttcgc aaatattcag 734101 aggatctcag ggcgcagact catgaatttt caaataagct ttatgcgatt ttagggctgc 734161 ttgagcttgg ggagtatgat gaagccattg atctgattaa agaggaatat gcgatacaaa 734221 atgaacagca tgatctttta ttccataaca tccattcgca gcaggtgcag gccattttgt 734281 tagggaaaat aagcaaggca tcggaaaaga aggtcaagct ggtgattgat gagaacagct 734341 cactcgcgcc tcttcctgcg catatcggct tgtcccatct tattacgatt attggcaatt 734401 taattgataa cgctttcgaa gctgtagcgg agcaaagcgt gaaggaagtt ttgtttttta 734461 tcacggatat gggccatgac attgtcattg aagtatcaga cacagggccc ggtgtgccgc 734521 cagagaaaat agaagctgtg tttgagagag gctattcttc aaaggggatg aggagaggct 734581 acggtctggc caatgtgaaa gactcagtgc gtgaactggg cggctggatc gaactggcga 734641 atcaaaaaac tggcggggcg gtattcactg tatttatacc gaaggagaaa caaaggggga 734701 atccatttga ttcacatcgc gattgcggag gatgattttc gagttgcgca aatccatgag 734761 agattgatta aacagcttga tggattcaag attatcggca aggcggctaa cgcaaaagag 734821 acattggcgc ttttgaagga acacaaggct gatttgcttc tgctggatat ttatatgccg 734881 gacgagcttg ggaccgcgtt gattcctgat atacgaagcc gatttcctga agtggacatt 734941 atgattatca cagcggcaac agaaacccgt catttgcagg aagcgctaag ggcgggaatt 735001 gcccactatt tgatcaaacc cgtaacagct gacaagttca ggcaggtgct gcttcagtat 735061 aaagaaaaaa ggaagctgct catgtctcag ccggaggtca gccaatccat gatcgaccat 735121 atttttggga acggtgtgaa gacagctttg ccggcagagg atttgccgac tggcattaat 735181 tcgattacac tgcgaaaaat taaggaagcg cttcagactg cgtcagaagg attgacagcg 735241 gaggaacttg gggaaaaaat gggggcgtca cgaacaactg cccgccgtta tgccgagtac 735301 cttgtgtcaa aggaagaagc aagagccgag cttgaatacg ggattatcgg caggccggag 735361 agaaaatatt atttggcggc ggattagata tgaaaaaatc tataatccta ttgaatattc 735421 tattgatctt tatgcagggt gatatcaggc aggcggctgc gccgcgcctg ccggacgggc 735481 cgatagaaat tgtcgtccct gccgaacctt ctggcggctg ggatgtcaca gcgcaggcga 735541 tccaatcagt tttgaggcag aagcagatcg tgaaggatga tgttcatatc gtctataaat 735601 ccggcggcgg gggagagaaa ggctggaaat atgtcaacaa aagcagcaaa caaaccatca 735661 gcatgacgtc cagcctaata ttgagcaatg atcttctcgg gcaaagcaaa ttaaaaatgt 735721 ccgattttac gccgctcgcc attctctcca aggaatggca gacggttgca ttgccaaaag 735781 gatcagcgtt aacaaatggc aaggatgtgc tgaatgagat caacatgcat cccggcaagg 735841 tgagaatcgg ctttgccccg gggtttggca atgatgatca gctctcgttc gtcagagcgg 735901 cagatatgta cggcattgac ccgtttgaca ttcaattctc acagtatgac agcagcgaac 735961 agctcattca ggcgctgatc agacatgaga tagaagcggc ttccatgaca ctttctgaag 736021 cgaaaccata tgaacgaaac ggcgatatca cgttagccgc tgtaacgtct gataaaagac 736081 ttcccggttt tccaaatgta ccgacgtgga aggagcaggg aatcccgttt gttttttctc 736141 attggagagg gattttgggc ccgaaaaata tgtctgagga agagatttct tactgggatc 736201 aagcgctaaa gaaggtcacc tcctcacctg aatggaagcg gaaaataaac gaacaggact 736261 gggaaagctt ttatttaaac agcagggaaa cgaaacggtt tttagaagag caatctgctt 736321 tttatcaaag catcatgaca ggaaattaaa atcccgacat cccgggattt ttttcatgcc 736381 gaaaattgat caaaaagaac aaaacggttt taaaaaatta aaaatacaaa aaaaccaaat 736441 tatttacttg cggttggttt tcccatacga tggcaaaaag gcaagacaaa aaggggagta 736501 agggagaaaa aaatgtaagc ggattcattt aagggggaat ggatgtgtta gcaatcttag 736561 gctttctcat gatgcttgtg tttatggcat tgatcatgac aaaacggctt tctgttttaa 736621 cagcattagt tttgacgccg attgtgtttg cgcttatcgc cggatttgga tttactgaag 736681 ttggggacat gatgatttcg gggattcagc aagtcgcgcc gactgcggtc atgattatgt 736741 ttgcgatctt atattttgga attatgattg atacaggcct gtttgatcca atggttggca 736801 aaattttaag catggtcaaa ggagaccctt taaaaattgt tgtcgggaca gcggttctta 736861 caatgctcgt cgccttggac ggagatggct cgacaacgta catgattacg acaagcgcca 736921 tgcttccgct ctatttgctg ctaggcatcc ggccaattat cttggcagga atcgcgggag 736981 tcggcatggg aatcatgaac acgattccat ggggaggtgc gacgccgagg gcggcgagtg 737041 cgctgggggt tgatccagct gagcttacag ggccgatgat tcctgtcatt gcaagcggga 737101 tgctttgtat ggtggcagtt gcgtatgtgc ttggaaaagc ggaacgaaag cgccttggtg 737161 tgattgaact gaaacagcca gccaatgcca atgaaccggc tgctgcggtt gaagatgagt 737221 ggaagcggcc gaagctttgg tggttcaatt tattgttaac gctttcttta ataggatgtt 737281 tagtatcggg taaagtcagt ttaaccgtac tgtttgtcat tgcgttttgt attgcgctga 737341 ttgtgaatta tcccaatctc gagcatcaga gacagcgcat cgcggcgcat tccagcaacg 737401 tgctggctat cggttcaatg atttttgctg cgggggtgtt cacggggatt ttgacaggca 737461 cgaaaatggt tgatgaaatg gcgatctcgc tcgtgtccat gataccggaa caaatgggcg 737521 gattgatccc ggcgattgtt gccttaacaa gcggcatttt cacatttttg atgccgaatg 737581 acgcgtattt ctacggggtg ctgccgattt tatcagaaac agctgtcgca tacggtgtgg 737641 ataaagtgga aattgccaga gcctctatta tcggccagcc gattcatatg ctgagtccgc 737701 ttgtgccatc cactcatttg cttgtcggac tcgtcggagt ttctattgat gaccatcaaa 737761 aattcgcatt gaaatgggcg gttctcgcag tgatcgtcat gacggctatc gctctattga 737821 tcggtgcgat ctctatttcc gtatgataat tcaggcgtaa tgacacacac taacggcata 737881 caacattccg gaggtgtcat tatgagtgat ccttatatgc cgctgacttc agtcagaagc 737941 ggagcggggt tcgaagcggc aaaaggggtg cacggcctga ctgtgcaaat tgcgaatgtc 738001 tattttattc agctgccttc tgaacctcac tcatttgttt taattgatgc cggcatgccc 738061 caatcagccg gcgtgattgt caatgaagcc aaacaaagat tcggtgaagg gtttcagctg 738121 aaggcgatta tcctcacaca cgggcacttt gaccatattg gggcaatcga agagatcctt 738181 gagcattggg atgtgcctgt ttatatccat tctcgggaaa tgccttatgt aacaggtaaa 738241 gaggattatc ctccggctcg tcctgacagc aagagcgggc tggtcgctaa gctgtcgccg 738301 ctgtttccgc ggcactctat cgatatttcc tcacatgtcc aggcactgcc ggaagacggt 738361 tcagttcctt ttcttgacga gtggatgtgg atcgcgacac caggacacac gccgggccat 738421 atttcgttat tccgcgatga cggccgcgtg cttgtggcag gtgatgctgt tattacagtg 738481 gaacaggaga aaatggctga cgtcttgata caaaaacagg agcttcacgg gccgccggct 738541 tatttcacgc ctgacacaga gacggccgct gagtccattc taaagctggc cggtcttgaa 738601 ccggaagcgt tattgaccgg gcacggcata ccgatgaccg gcaaaaactt tcgaagtgac 738661 ttaactgaat tggcaaatcg gttatcgtct atttgacacc cgcaccacgc gggtgttttt 738721 tattgttttc caggaagttg cagaaaaatc atttgtcttg ccgcttaaaa acgatacaat 738781 gaaaagcatg aagtgatgtg aaggggagag tttgttggaa gaaaaagaaa tactctggaa 738841 cgaagcgaaa gcgtttattg ccgcatgcta tcaggaattg ggaaaggagg aggaagtgaa 738901 agaccgtctc gcggacatta aaagtgaaat tgacctgacc ggaagctatg tacatacgaa 738961 ggaagagctg gagcacggag cgaaaatggc ttggagaaac agcaaccgct gcatcggcag 739021 attgttctgg aattcgctga atgttatcga cagacgagac gtccggacga aggaggaagt 739081 gcgtgatgcc ctctttcacc atattgaaac cgccaccaat aacgggaaaa tcagaccgac 739141 cattacgatt ttccctccgg aagagaaggg tgaaaagcaa gtcgagatct ggaatcatca 739201 gctgatccgg tacgctggat atgagtcaga cggagaaaga atcggcgacc cggcttcctg 739261 ttccctgaca gcagcctgcg aagagctcgg ctggcgcgga gagcgaacgg attttgacct 739321 gctgccgctc atttttcgca tgaaagggga cgagcagcct gtctggtatg agctgccgcg 739381 ttcacttgtg attgaggttc caatcacaca tccggacatc gaggcgtttt ctgatttgga 739441 gctgaagtgg tacggcgtgc ctattatttc tgatatgaag cttgaggtcg ggggcattca 739501 ttataatgcc gcgccattta acggctggta tatgggcacg gagatcggag cgagaaacct 739561 cgcagatgaa aagcggtacg acaagctcaa aaaagtagcg tccgtgatcg gcatcgccgc 739621 tgattacaat acggatttat ggaaggatca agcgctagtt gaattgaata aagctgtgct 739681 gcactcgtat aaaaagcagg gtgtcagcat cgttgaccat catacagcgg caagccagtt 739741 taaacggttt gaagaacagg aggaagaagc gggcagaaag ctgacggggg actggacgtg 739801 gctgattccg ccaatttcac ccgctgccac tcatatcttc caccgctcct atgataactc 739861 aatcgttaag ccgaactatt tttatcaaga taagccttat gagtaaacaa tagaaaatcg 739921 atgatggcct tcaaggctgc gggattcagt cacagagatg tcggtaacct ttgagaaagg 739981 gcttccgttc tttacagcct caacaaacga ttgcagggcg ttttccggac cctctgccaa 740041 aatctcgaca cgcccgtcat cacggttttt gacccagccg gccagttttc gcttatcagc 740101 ttccatttga acaaaatagc gaaagcccac accttgaacc cggccgtcta caatgattcg 740161 gtattgaagc atgtaaaaac caccttttct ttttatgata atcaatcatt ttacaacctg 740221 taaaggggat gtgtttgtat gaaacaagag cgctattcag ttctttctct taatctggga 740281 aaaccgcaga cgcttgaata tgacggaaag aaaatcgaaa ccggcatcat gaagcggccg 740341 gctaaatcag ccgtcatgct gtatcgggag aattttgaag gagacggaca ggcggacctc 740401 gtcaaccacg gcggacctga taaggctgtc tgtgtctacc cggcggagca ttatccgttt 740461 tgggaagagt tcctctcaag accgctgtca aatgccgcat ttggagaaaa tctgacggtc 740521 gcgggcctga ctgaggagaa tgtttgcatc ggggatgtgt tcagacttga tgaagctgtt 740581 gttcaggtca gccagccgcg ccagccgtgt gtaaagctgg cgaaaaagtt tggtgtaaaa 740641 gaaatggtgc tgaaggtcca gcaaaccggc tatacagggt tttattttcg cgtgctggag 740701 gagggcaggg tgtctcccgg cgcgaacctt gaattgctgt ccagaggaga gaaaggcata 740761 tccgtccagt tcgcgaaccg catcaactac catgatgcaa aaaatctcac cgccattgaa 740821 cggattttaa gtgaggctgc actatcggaa agctggagag cgtcctttat gaaaaaaaag 740881 gacaggctgc tgccggttga atagaaaaaa gccgcgcata tcaacgtgcg cggctttgcc 740941 atatttaaga ttgttttttc tttgattcaa gcaggttggc aagaaaatag gttttatagc 741001 tttgaagctt tcttccttca tggtgcgtga tcccctgctt ttttagttct gccacatacc 741061 agcctttact gccgtaatgc atgtcagaaa actcctttcc ctatctgatt tcgaaacgat 741121 tggcattgta acatctataa aaagatgctg aaaagagatg cggggaaaac tgagcctttc 741181 gcactagatg tacgaatgtt cttctgaatg tatatgcgga gcaaaagccg aatatgattt 741241 aatggccggt tagtttgatc atgacaacgc caaatgtcat aatggcgaaa acaatgccga 741301 tatatgtgag catcccgttt tttttcttaa cgccgtaaac ggtcataatg atgccttcaa 741361 tgaaaaaaat gatgccgaaa ataataaacc acatgcagat aaaggctcct ttcacagaca 741421 taatagtagt gtagcatatc tgaaagagcc gggctgtgac aatatcaaga aagccgggcg 741481 catatcgccc ggctcatgtt ttattgttta tcaaccaatt tgaccagaag ctgtgccaaa 741541 tgttctttct catcttcgtc tgcaacgctc caaagctctt gcagcagcat ttcttcaccg 741601 ttttgcggct cttcatgctt tgcgaggtag tctcccagga tcgcagcgct ttttacaagc 741661 ttgccgtcat ccaatcccag ctttttgcct cggttgactt gttttttcag gtagccttta 741721 aattcctcaa agtcttttaa aatgtcttct tttattgtgc catgcatcgc gttcatttcg 741781 ttttcaattt ggattttttc ttgatctctg ttcattgcaa gacctcctcg tacagaataa 741841 tgatgcttta cctgcaattg gaggaggtta aacctgccgg aagcccggaa tgtgttttac 741901 agtttcgtca ggataatcgg ttcatctttt gtgatgacga tcgtgtgttc aacttgggca 741961 accatgcttt tatccggcgt cttgaacgtc cagccgtctc cagcttcaac aatcgtttct 742021 gctttcgttg aaataaacgg ttcaagcgcg atgactgtgc catttttgaa cagcgcatta 742081 tcaaacggat cataatagtt catgatgtgg ttcggcgctt catgcaggct tcggccgatt 742141 ccgtggccgg tcagggtttt gatgacggta aagccttgag agcgtgcttc atgataaacg 742201 gctcttccga tctggttttg gcgcttgccc gcttttgcct gctgaagccc cttttgaaaa 742261 gcgttttccg cgcattggca aagcttatga aggcgttctt ctccttcacc gagcacaaat 742321 gagatgcctg tgtcggaata gaagccgcca aattcagcgg agatgtcgat gttgacaagg 742381 tcccctgctt ttaaaatttt ggatgtgctt ggtatgccgt gagccacttc atcatttacg 742441 ctgatacatg tcacacctgg aaaatcgtat tccttctcag gagctgaaac ggcgccgtgc 742501 tcatcaagca cagcttttcc gataaggtca aggtcttttg tgctcatgcc gggctctgcc 742561 ttccgcttca tttcttcacg cgcaagcgcg acgattcttc cgattttttt caggccttct 742621 aattcttgat cgtttgttac aatcatctgt cattcccgct ttctttttaa ataatctaga 742681 ttaagcttac cacaactgtc ttaaaaatag gaaacacacg gacctgggaa aaaagaaata 742741 cccccgggaa aattggtata gatcactaga tatcttatat ggtatatttg aaaaaaaagg 742801 gtatgagggg gatgggtatg ctttcatttt tacaaaaact cgggaagtca tttatgctcc 742861 cgattgcggt tctgcctgcg gttggaatta tccttgcgct tggcagagag gatgtattta 742921 atatcccgtt tgtctatcag gcggggacgg cggtttttga tcatctgccg cttatttttg 742981 cgatcggtat tgccatcggc atttcaaaag acagcaatgg ggcagcgggt ttatcagggg 743041 cgatatcgta tctgatgctt gacgcggcaa caaagacaat tgataaaaca aataacatgg 743101 cggtgtttgg gggaattatt gccggtttaa ttgccggtta cacctataac cgcttcaagg 743161 ataccaagct gcctgaatat ctcgggttct tcagtggcag acggcttgtg ccgattttaa 743221 cagccattat tacgatcatt ttagcgggca tattcggagt ggtctggccg ccgattcaat 743281 cgtgtatcaa ctcgtttgga gagtggatgc tcgggctcgg cggcatcggg gcaggcatat 743341 tcggcctatt caacaggctg ttaattccgc ttggccttca ccatgtgctg aacaatattt 743401 tctggttcca attcggagaa tataacggag tgacagggga tttggcgcgc tttttcgcga 743461 aagatccgac tgcgggcaca tatatgaccg gatttttccc aatcatgatg ttcggtcttc 743521 cggcggcgtg tctggctatg gttgtgactg cgaagccgtc taaacggaaa gcgacggctg 743581 gaatgatgat tggatttgct ttaacggcgt ttatcacagg gattacggag ccgattgagt 743641 ttgcatttat gtttttatct ccgcttttat acgctgttca cgcggtctta accgggttat 743701 ctttatttat cgtcaactgg ctcggcatcc gctcaggctt ctctttttca gccggagcta 743761 tcgattatgt gctcagctat ggaatcgcgg aaaaaccgct gcttctgctt ttggtaggta 743821 tatgctatgc ggcagtatac tttatcgtgt tttatgtact gattaaggct ttgaatttaa 743881 aaacgcctgg acgggaagac gatgatgtgg atgaagtgct ggatgaaaat actgttcagg 743941 atgtaaatga aaacatcatg ctgaaagggc tcggcggaaa agaaaacctt caaaccattg 744001 atcattgcgc cacaaggctg cgactgactg tgaaggatac cgctttggtg gatgaagcac 744061 tgctaaagaa agcaggcgca aaaggggttg tcaaatcggg cgggcaatcg gttcaagtca 744121 ttattggccc gaatgtggaa tttgcagctg aggaattgag ggctgctgtc aaataaaaaa 744181 gcggagaggg caacctctcc gctttttctt atttatcttc gttatccttt gacgtttcgg 744241 aagaatcttc gtcatgtttt gtgtaatcat aatcagaagg attcaccttc ttaaaacctt 744301 tcggctcgta gaaccgcagc aggtctccgt ttatgatttt atcggacatt tcaagttcct 744361 tcttgacgag tgagtcttct gacttgtcga cttcggattc atcgagttct tttccggttt 744421 tcgtgtcgta atacttaccg gatattttcg tgtacttcgg tgaaataaag tctccgtttc 744481 ggaacggaat cacttcacgg tgttctttcg ataaaatatc agaaccggac atcagatagt 744541 ccttcgtatc cactccgagc agatgcagaa tggtaggagc cacatcaacg tctccggcat 744601 atttatgaac tttctcgccc ttcacgccgg cagcgtggat aaagagcggc acccgttgaa 744661 gctgggcgtt gtcgtaatca gtgatttcat ccttgccaag cactttcgcc atcgctttat 744721 tgtggttttc agagatgccg tagtggtctc cgtacatcac aataatcgat ttatcatata 744781 acccgtcttt tttcagatca ttgaagaatt gttcaatgga ctgatcaagg taatgggctg 744841 actggaaata gttatcgacg acagagtcac caaagtctcc agccgggaag tctgtatccc 744901 cctcatccat tccgaatggg aagtggttgg aaagggtaat gaacttcgta tagaacggct 744961 gcggcaggct ttccagcagc ggcattgatt ctttgaagaa cggtttgtct ttcatgccgt 745021 agtttttcgt gttttcttcg ttcatgtcat agtaagcaga atcaaagaat ttatcaatgc 745081 cttccgcctt gtacatttcg ttacggttcc agaacgtctg cgtgttcccg tggaaagtag 745141 cagatgtgta attcttagac ttcagaatcg ccggaacgga ttgcagcgtg ttttgcgctt 745201 tgtttacgaa aactgaacct tgagccagcg ggtacagaga gttttccatc ataaattcag 745261 catcagatgt tttaccttgt cccgtttggt ggaaaaagtt atcaaagtag aacgtttcgt 745321 tatcatgtgc cagtttattt aagaatggtg tcacttcttt gccgtcaatt ttatagtcga 745381 tgataaatga ctgcaaagat tcaagtgaaa cgtaaatgac gttttttcct tccgctttgc 745441 cgaaatacac gttattcggc acatcgtaat tggctttcat gtagttttct acttccgtta 745501 cgtcgctgga atcggcaagc gcgcgctggc tgttggactt gatattctgt acagcgtcat 745561 aaatcgtgaa attgtatgtt cccaagtatt tcacaagata gttccggtcg aatgatcttg 745621 tcagcaattc aggacggtct gattccgcaa ctgccaggtt gatcaagaac acaagaattg 745681 aagacgcaaa aataattcgg aacgattttt tgcttgacgt ttcggcaggc ttgtttactt 745741 tgatcgccaa gatgatcagg atgatcgtat cgataaagta aaaggcgtca gtcggtctca 745801 tcagcgaaaa tgcgctgtca ccgagttggc cgccgtttgt tttagcctgc ataatgaccg 745861 gaattgtaat aaaatcattg aaaaatctgt agtacacaat gttggcgtac agtaaaaaag 745921 acattaaaaa atgaatcact ataatggctg tctgctgtaa ttttttcttg aacaagagtc 745981 caaagccaag aaagaacaag cttgagctaa gaggattcac aaaaagcaat attttttgta 746041 tcgtgttgtc tattcctaag ttgaaattca ggacataacc gacatacgtt ttgatccata 746101 acaggacgac cgcaattaag aagaaggcca gtcctctttc ttttataaat gttttcattg 746161 ttacactcct tttttccgat ccagttcgag cgaaacgata gaaaaaacga acgtatccaa 746221 tataacacga atcagcagat tagaaaagtg aaaatcgtat gagggagaaa gtggcgaaaa 746281 acgccgtcga atcaacgttt cgctttgata ttaccaaatg taaaacaagg tatctttcta 746341 gaaataaagg aataaaatgg tacattgaga attgtatgat aaaatataag gtatagataa 746401 aaagaggtga aatgatggat ttttcccata ttgtgtctga agataaaatt aagcgcgcca 746461 tcaaagacgg ggactttcaa aacctcccgg gaatggggaa gccgctgccg aaggatgacg 746521 cggcacactt gccggaatcg ctgcgcatgg gctatcgtat tttgaaaaac gcgggaatgg 746581 cagaggacga gggcgcgctc aaaaaagagc ttatgaccat cgaccattta atcgaaaagt 746641 gctatgacga aaaagaacgc gagcaattaa tcagaaaaaa atctgaaaag caattgctgc 746701 ttgataagct tgtcgacaaa aaaggcatgt tttcaaagcc agcatccgct ttttataaga 746761 ataaagtata tgaccggctt ggacgaaaca gaccttcttc cagctgattt gtcttgtctg 746821 caggatggcg attgataaaa gccatccttt ttatgttcca agttctatgt caaaaggttt 746881 atgtttttcc atctatggga aatgattcat aaacgaaaaa agggtgatgg gatggaacga 746941 ctattagtat ggatagagca tatatctgat tggctgtggg gtccgccgct aatcatcctg 747001 ctgacgggga cgggcttgta tttcactatt ttgctgaaag gttttcaatt tcgctatcct 747061 ttatacattt tcaaacagac aatcggcagt gtaggaaaaa agccgaaggg agaaggcaca 747121 gtcacaccgc ttcaggcatt gacctcagcc ctcagttcaa cgatcggtgc agcgaacatt 747181 gtcggtgtgc ccgccgctat tatgtttggg ggaccaggag cggttttttg gatgtggctt 747241 attgccttat ttgccatggc gattaagttt tctgaaagtg ttcttgctgt tcattacaga 747301 gaaaaaaatg agcagggtga atacgtcggg ggaccgatgt attacataac aaaagggctg 747361 cgcatgaaat ggctcggcgt attcttctct gttgcgctga ttgtggagct gattcccagc 747421 attatggttc agggaaattc ggtttcagtc tcgcttgccg agacgttttc tttcaataaa 747481 atatacgcag gaatcggaat tgcatttttg attgggttag tggtgatagg aggggtaaag 747541 cggatcggaa aagtaacaga gtttgtcgtg cctcttatgg caggggcata cgcaggtgcc 747601 ggtctcctga ttgttctcat gaatctatca tcagtgccgg cgtttttctc tctcgttttt 747661 tcaaatgcgt ttacctcttc ttcagcagtt ggagggttcg caggtgctgc gttggcggaa 747721 accgttcgct ggggatttgc ccgcgggctg tattctaatg aagccgggat gggaacagcc 747781 ccgattgcac atgcggcagc aatgactgat catcctgtgc ggcaagggtt ttggtctgtg 747841 atcggcattg tcattgacac cttaatcatc tgtacgacta ccgcttttat cgtccttgca 747901 tccggtgtat ggacagggaa gaacgcctca aatgacccgg cagcactgac aacggccgca 747961 tttcagcact atttcggttc tggaggagga tacttcgttt cggtttccct ggtcttcttt 748021 gtcgtatcaa ccattatggt tgtcattttt tacggcgtaa agcaagctga atttctgttc 748081 gggcggctgg caggacatgt gattaaattc gtttatttag cggctattat cataggtgcc 748141 gcaggcggag caaaagccat ttggggcgta ttggacttag cattggtttt tattgttgtc 748201 ccgaatgtga ttgcgctctt gttattgagc agaaaggtaa aagcgctgta caccgaattc 748261 tttacatctg aacagtacta cctgaaagat ataagaaaaa cgaaacaaaa gcctgtttat 748321 ccaacaaaag aagctaaaaa ttcctagtgt tttgcttttg cgccgaacaa tgctttgctt 748381 tttatgatca aataaatgag taaaggcagc aaaagagaaa tcactacatt aatgattggt 748441 ttgattctgt taaagtcgat tagctgattt gtatttaaaa aaaaccaaaa gccgcatacg 748501 actgagaaca tgccggttgg tgtatacatg gctttcgggt cgatttttga gtgtaaaaac 748561 gaaaggccgt ataccacgat atatagggaa cctgctatct tcaccataat gaccggaatc 748621 caaaaagccg cgatgatcag gtctgagcga tccagaaaat ccgtaatgcg gatctgcctg 748681 atgaccatat aagcaggatc aaagaaagta gatgtcaggt tgggaccaaa gacagaaatt 748741 gaagaaaata acatcacggc cagcaataaa gcgcccagca gtatcgcgaa aatggtgtat 748801 tttagcggga cgctccggtt tgagaagaga agcggaagga taatcaattc ccccattgtc 748861 ccaaacgcgt aatagcctga ttgaaggtat gggattagac cttcaaaaac aggtgtcaag 748921 ttttgaagct caatttgtgt ggccagcgta aatggaagga acaagaccag gatgccgaat 748981 ggaaatagga atatctgcgc cattctggtc aatgtttctt ttccctctct ggcaatacag 749041 atcgccacaa agataataac accgccaaga acagccattg gtgttctcgg gagaaataaa 749101 atgttaatca aattgatgaa aaaacgtata tcatgagcat tgattaacag gaaatacaaa 749161 gaaaacagta aaatgataat ccggcctgcg attggtgagg aatcgctcag cagctcatag 749221 atatttttat cctgatgctt tttcatcagc ctatgcatga gccagagtgc cggaatcacg 749281 atgacaacgc cgaggatgta gctgtgccag gcattttgtt ttgctgattc gatcatgaga 749341 atcggagcat gctttaatcc gactgctaac gtatacagag ctccgaaaaa taatccttgg 749401 tatgcagagg tcttgtccat aaagcacatc ctttctgtca tgttcaaaac ggaatatatt 749461 taaacaggtg ccccagccgc ggaagcaggg gattcactct catataaatc catagaaaag 749521 cacttcctgc aattagcagg ctgaaggccc attttgttag attgttagcg gaacgaaaat 749581 tcttccattc atatgcgtat atggcaatgc acacaatcaa tgtctgtacg atatagctga 749641 tcatgctgac gcacctccat taatggctga tcgttttgta taggacaccg ccctgctcaa 749701 tcgtcacaat tgggacgacg tgaacctcca tatccttata tacctcttcc cattcctttt 749761 tcagcagatt cttcgtggtt gccgtgcttc tgatggtcct gtcttgaaag ccggccgggt 749821 ccgcctttag cttttgcaaa cgatgaacgg tgctgatcac gtccttcttt atggttctgt 749881 ttaatgcttt ttgaatgatg taatactggt cattttctct cgtctcatag gttgattggt 749941 tttccataat aattcctttg gctctgatct cgattgtcat tgacagcttt ccgttttttt 750001 cagcggcatg aaaggatgca ttggactttt gaagctgaat ggatgcttgc cccatttgat 750061 tcggcaggtc tactatgaat tctggctggc gggcttgatt cagcaacatc agggctgctg 750121 tcatgtgttc atctttgaaa atatccatca atctgtcctt tttaaagatc gcaagcccgt 750181 caattttcaa attagatttg cctttccctc caggttttgt tttagatgca gagatgaccg 750241 gtgcatacgg atcactgcct atttctacta gatcagacat gaatctgctt aagaaaacgg 750301 ggcggctcgt tgcgataatg gccagctccc gaatcatttc cgccggaaac tgttcaagct 750361 gaacatcggt atttaaaatg tcccgcgctt ctccccggct gactaaaatg agcgccgtta 750421 atctgttctg cggatttcgc gttaaaatat caaagactgg ggcaacgccg tctctcgcca 750481 tatcctctcc aataatgact gtacgtctgt gggacgtatt gattgtccgt gacaaggagg 750541 tttgcagctt gttgttcgct tctctgatcg tagtgccgga agctgaatca acataccatg 750601 tttttgaacc ggcagttccg ccgccgcccc ctgtttgtcc gcctaattgg ccgaccaagg 750661 gaatctgcat ggccactcga tactgatctt ttttcttatc aatggctgag ctgacaacaa 750721 atgcaatgtc attgatttct gtccggtccc agcaccccgt tagaaggata caaatgagaa 750781 gcggcaaaac acacttatat attgttttct tcatcttttg ggtcctctct tttcgctccc 750841 ttctgtccgt tgccgcgcga atacgtgccc ggccttctgg tcatcgtcca ccaaggcgcc 750901 ctgacaaaaa tatcttttac ttcatctcgt ttaaacggag aaatcccgga taaataagga 750961 atgccgaaag attgcagctt gcataaatga agcactaaga taatcgtgcc gagcataatg 751021 ccgaatatcc caaaaatact cgccaaaaac ataagcggga aacgaagcat cctgatggag 751081 atagctaagt taaaccgcgg aattgtaaat gacgcgatcc ctgttaacga tacgatgatc 751141 accatggggg cagacacaat tcccgcttca acagcggctg tcccaatgac tagggccccg 751201 agaatactga cggtctggcc gatggttttc ggcaggcgca ctcccgcctc acggagagcc 751261 tcaaaagaaa tttccataat caatgcttct atgatggcgg ggaaaggaat cggttcacgc 751321 gcagaggcca cactgaacat taagtttgtc ggcattaagt cctggtggta tgtaataacg 751381 gcaacataaa tagccggcaa atataaagca acgaataaaa acatatagcg aagccagcgg 751441 attaagttag acatcaaata acgctcatag taatcttcac tggcctgcat aagctgccaa 751501 aacgtaatcg ggcctgttaa gacaaagggc gtattatctg tgaaaatggc aaatcggcct 751561 tcgagaagct gggcggcgac ggtgtccggc ctttctgtgt attgcagctg ggggaatggc 751621 gagtacgtgt cgtcttcgat aaattcttca atatatccgc tttctaagac agcatcaatc 751681 tttatctttt tgattctttt ttttgctttg tcaataacct ttggatcggc aagcccgtca 751741 atataggcca agacaacatc ggttttggtt ttcgtgccga ttttaaaaga gatcatttta 751801 agctgaaacg ttttgacgcg aaagcgcaca agagcggtat tgaccctgag gctttcagtg 751861 aagccctctc ttgaccctct gatggtcgat tctgttatcg gctcttcaat gcttcttctt 751921 tgtccgcctt ttatatttaa gatcaggcct tttgagtgcc cgtcggcaaa taaaaccgcg 751981 ttcccctcaa tgatggatgc agccactttg ctcatactcg tttctaatgc aacacttgaa 752041 attgatagag tattttgcag cgcctcttca tgttcatcta tttgatccgt caaatgcatt 752101 aagaaagggc ggagggcgtg atcctgaata tgttcagatt ttacaattcc ttcgatataa 752161 acaataaatc cgcacagccc gtttccaaag tcaaattgtc taaatacgat gtctgagcag 752221 ccttctgtta ataaggtcag attttcgagg ttttccttca aattgggaga gatcggtctg 752281 tcctgattgt cttcaagctc tttgatgagc tgaagcgctt tgtcgcgttt attcatagag 752341 gctcaccctg ctttttaatg tcatattcaa taagtgcttg tgacttttag ggtaaccttg 752401 tctgtttcat atattccaga ctaggatgaa agcgctataa aaaagtgttg actacctgta 752461 tatacaggaa tacaatatga ttataagttg tatatacaag ttataaaaac ggatacggag 752521 gggttggcat gggggaactg aacaaatcgg cacgtcagat tgtcgaagca gtcggcggtg 752581 ctgaaaatat tgcagcggca actcattgtg ttacacgttt gcgttttgct ttaatagatg 752641 aaagcaaggt tgaccaagag atgcttgatc aaattgatgt ggtaaaggga tcattctcga 752701 caaacggaca gtttcaggtc gtaatcggcc agggaactgt caataaagta tatgctgaac 752761 tggttaagga aacggggatt ggcgagtcaa caaaggatga agtgaagaag gcctcagaaa 752821 aaaatatgaa tcctttgcag cgtgctgtga aaacgcttgc agatattttt attccaatat 752881 tgcctgcgat tgtcacggcg ggtcttttaa tggggatcaa taacatttta acggcggaag 752941 gcattttctt cagcacaaaa tcgattgtgc aggtttatcc gcagtgggcg gatcttgcta 753001 atatgattaa cctgattgca ggcacggcct ttacgttttt gcctgcgtta atcggatggt 753061 ctgccgtcaa gcggttcggc ggcaatccgc ttctcggcat tgtgctcggg gttatgctcg 753121 tgcatcctga tttgctgaat gcgtggggat atggcgcggc agaacaaagc ggagagatcc 753181 cggtatggaa tctattcggc ctagaggtgc agaaagtcgg ctatcagggc caggtgctcc 753241 caattttgct tgcttcttat atgctggcga agattgaggt atttttaaca aaacgcacac 753301 ctgagggcat acagctgctc gttgtcgcac caattacgct tctcttaaca ggatttgcct 753361 cttttatcat tatcggcccg attacatttg cgatcggtaa tgtactgact tcagggctta 753421 tctcggtgtt tggttctttt gccgcactgg gcggtctgtt atatggcggt ttctactcag 753481 cgctcgtgat taccggtatg catcacacgt ttcttgcagt cgacctgcag ctcatcggtt 753541 caaagctcgg cggcaccttt ttatggccga tgctggcgct ttctaatatc gcacaaggtt 753601 cggcggctct ggccatgatg tttatcgtga aggatgagaa acaaaaaggc ctctccctca 753661 catcagggat ttctgcttat cttggcatta cagagcctgc catctttggg gtgaatctgc 753721 gatacagatt cccgtttatc attgcaatgg tcagctctgg cctggccgga atgtatattt 753781 cttctcaagg tgtgctggca agctccgtcg gtgtcggcgg cgtgccgggg attttctcaa 753841 tcatgagcca gtactggggc gcgtttgcaa tcgggatggc tattgtattg atcgtgccgt 753901 ttgccggaac atacgcgtat gcgagattca aacataaata acaagtgggg agcgggacgt 753961 gttgaacgtt cccttttccc gttttcaatt taaatatggt ggtggaaaca gatgaaaaca 754021 gaacaaacgc catggtggaa aaaagctgtg gtttatcaaa tttatccgaa aagctttaac 754081 gatacgacag gaaatggtgt tggcgatctg aacggcatta ttgaaaagct ggattactta 754141 aaaacgctac aggtggatgt gctttggctg acgccgattt atgattctcc ccagcatgat 754201 aatgggtacg atattcgtga ttattactcg atttatcctg aatacggaac gatggaggat 754261 tttgagcggc tagtgtccga agcacataaa agagacctga aagtcgtcat ggatcttgtt 754321 gtcaatcata cgtcaacaga gcacaaatgg tttcgcgagg cgatctcttc aatagacagc 754381 ccgtaccgtg atttttatat atggaaaaaa ccgcaggaaa acggttctgt tccgacgaac 754441 tgggaatcga aattcggcgg ctcggcatgg gagcttgacg aagcatcggg ccaatactat 754501 ttgcatctgt ttgatgtgac gcaggctgat ttgaattggg aaaatgaaga ggtcagaaag 754561 catgtctatg acatgatgca tttttggttt gaaaagggaa tagacggctt taggcttgat 754621 gtcatcaacc tgatttctaa agatcagcgc tttccgaatg cggaggaagg cgacggccgc 754681 tctttttaca ctgacgggcc gcgggtgcac gaatttctgc atgaaatgaa cgaaaaggtg 754741 ttttcacatt acgacagcat gacggtcggt gagatgtctt caacaaccgt agaccactgc 754801 atccggtata cgaatcctga caataaagaa cttgatatga cattcagctt ccatcatctc 754861 aaggttgact atcctaacgg cgaaaaatgg gccttggcgc cgtttgattt tttgaagctg 754921 aaggagatcc tatctgactg gcaaacgggg atgcacgcag gagggggatg gaacgctctg 754981 ttctggtgca atcatgatca gccgcgcgtc gtatcaagat atggagatga tggcgcatat 755041 agggtgaaat cggcgaaaat gcttgctacg gccattcata tgatgcaggg cacgccttat 755101 atttatcagg gcgaggagct ggggatgacg aatccgaagt tcactgacat aagctcctat 755161 cgggatgtcg aatcgctgaa catgtatcac gcctttaagg aaaaaggaat ggctgatcaa 755221 gatattacag ccattttaca ggcgaaatcc cgtgacaatt ccagaacccc cgttcagtgg 755281 gatgctacgg aaaatggtgg ttttacaacg ggcacaccat ggataccggt tgcaggaaat 755341 taccgggaaa tcaatgctga agcggcgctg agggatcaga attcggtgtt ttaccattat 755401 caaaaattga ttcagattcg caaaatgtat gacattgtga cagagggtac gtatgagata 755461 attgcaaagg atgacccgaa catttttgcg tatctcagac acggcagcaa tgaaaagctg 755521 ctcgtgatca ataattttta cgggacagag gcggccttta cactgccgga ctctttagcg 755581 cctgacgaat ggaaggcaga ggtgctgttg acgaacgatg aagcaaggga agggcttcag 755641 aacatgacgc ttcgcccata tgagtccatt gtttatcgtt taacgaaacc gtgttaaact 755701 aagctgggtg gtccataatg aaggtgaata aattcatcac aatttataaa gacatcgcac 755761 agcaaattga aggcggccga tggaaagcgg aggagattct tccgtctgaa catgagttga 755821 ccgcacagta cggtacatca agagaaacgg tccgaaaggc gcttcatatg ctcgcgcaaa 755881 acggttatat ccagaaaatc aggggaaaag gctccgtcgt gctcaatcgt gaaaaaatgc 755941 agtttcccgt ttcgggcctt gtcagcttca aggagctcgc gcaaacgctt ggcaaagaaa 756001 cgaaaacaac tgtacacaaa ttcgggctgg agcctccgtc agagctgatc caaaaacagc 756061 tccgggccaa tctggatgac gacatctggg aagtcatcag gtctagaaag attgacgggg 756121 aacatgtgat tttggacaag gattactttt tcagaaagca tgtccctcac ctgacgaaag 756181 aaatttgtga aaactccata tatgaatata tagaaggaga gctcggtctt tcgatcagtt 756241 acgcccaaaa agaaattgta gccgagccgt gtacggacga ggacagagag ctgctcgatt 756301 tacgcggcta tgaccatatg gtcgtggtga gaaactacgt ctttttggag gataccagtt 756361 tgtttcaata tacggaaagc agacaccgtc tcgacaaatt ccgatttgtt gattttgcgc 756421 ggcgggggaa atgagagagg cgcctgcctg cggcagcgcg cttttttgtt tggtatcaaa 756481 attgatacta tccaacaaaa atgtgcgtac ttttactttt tatcataatg gctacaatag 756541 agatgagagt aatctaaagg agaggtgttt tacatggcag atctaaagac acaaattctg 756601 gatgcataca atttcaggca tgcgactaag gaatttgacc cgaataaaaa agtgtcagac 756661 agcgattttg aatttatttt agaaacagga agactgtctc cgagctcact cggccttgag 756721 ccttggaaat ttgtcgtcgt ccaaaatccg gaattccgcg agaagcttcg tgaatacaca 756781 tggggcgcgc aaaagcagct gccgaccgca agccatttcg tcctgattct tgcgcgtaca 756841 gcgaaggata tcaaatataa tgcggactac atcaaacgtc atttaaaaga agtaaaacaa 756901 atgcctcaag acgtgtacga aggctattta agcaaaacag aagaattcca gaaaaacgat 756961 ttgcatttgc ttgaaagtga cagaacattg tttgactggg catcaaaaca aacctatatc 757021 gcgcttggca acatgatgac tgccgctgcg caaatcggtg ttgattcctg cccgatcgaa 757081 ggcttccagt acgatcacat tcaccgtatt cttgaagaag aaggccttct ggaaaacgga 757141 agcttcgata tttctgtgat ggtggcattc ggctaccgag tgagagaccc tcgtccgaaa 757201 acaagatctg ctgttgaaga tgttgtgaag tgggtttaaa agaagaaagc tgctcgcata 757261 gcgagcagct cttttttatg cctgattcgc tctattctgt tttctcctct gatgtaagta 757321 cattgccgtt ccgagtgcgc tgatcagaaa tccggccaac aggatcgagt acatggatgt 757381 ggctgtgtcc ggaagcaggc cgccagccgg accgtctgtt cctgatccgc ccgaaccgtt 757441 tccaccagag ccgttagtcg gttgagtgcc gggaggcgta tcatttcctc cgtttccgtc 757501 agttggctgt tttccgcctg gtttgtcgga gcctccgcca tgattgccgt catcaccgcc 757561 tgtcggttga tctgacggga atgccggcgg tttgttgttt gaaccggaat ttaagatcgt 757621 gtattcgctg aagtggtttg tatatcctgt caccatatca tcatcgactg atccgtgacc 757681 tgtctttgtg aaagctttct tttttctatc gacgtgataa atggcagggt tatgggcttc 757741 ttcaatatca aacatgcgaa gcgaaagctg tacgggctcc ttgaatgatt ttatttcttt 757801 tcctttttgc ttcactgtaa agtcatatac atctgacagt gacacatcca attctcccgt 757861 agacttgatt ccgattgcag tgtctgcggt tttaaggttc gccattggca tcttcatgct 757921 gtaccagtag ttgaacatcg tcaatgaagg atctgactct ctttctttca aaagtttgac 757981 ctgatctttt ttcactttaa gattgatagg cttctcttga gatccttcat gtattccata 758041 atagacaaat ggcgtgttgg catttttagc ataaatcgca aatttgtctt catcaagtgt 758101 ccagctgccg tccttctgct ttgtcggcag gaatacttct ttgattcgtc cttcaacttt 758161 aggagagacc ttgtttccta gttttttcag ctgttcggtg aaaatctcat aatcaacgta 758221 gccaaggtct tcaccatggg aggcttctgt aaagacagaa tatccgtctc ctccggcacc 758281 gacaaaatta tttgttgcca cgcggtaggt atcatccgta tttatagcaa ctttgtctcc 758341 gttaggcgat tcaattttca cttctaacac acggtgtcca ggtttgttgt ttaatgtaaa 758401 ggtatattcg attccggcca cctgagggaa agcgccgccg ccattttcca cattgcttag 758461 gccttgttca agggcttctt taatttgttt tccggttaaa tcggccacgt aaagcgtatt 758521 gccgaacggc atcacgttga gcacctcgcc gagtgtgata tcacctttgt caatgcctgc 758581 tctgatgccg ccgccatttg ttatcgctat tctggcgccg gctgcttctt tcgcttttgc 758641 cagcataccg tccgcgatga agtttccgag attcgtttct ttcgtgcgca catgctcacg 758701 ctggccgtca agcgccacat ccgtgtagcc gactttttca tttttcacgt cctctaattc 758761 atttttgaac tgatcgagct cttgttttgc ttctgggttt tcttctgtat gttcatcaat 758821 tggcagcacg ctcagatttg atttatctgt ttgcacaacg cctttttcat caaacgcgac 758881 atcaacgcgc cccaagaatt ggccgtattc ttttgcctgc gccacgatcg tcggttcttc 758941 gttgttcacg acctccattt tgtctacgag ggtgtgagtg tgtccgccga tgatcaaatc 759001 aatgcctttt acttttttgg ctagctcaag atcccggtta tgtccgatgt gggttaaagc 759061 aataatttta tttacctttt cttcttcttg aatcgctttg acggtgtttt gtgctgtttc 759121 aaaggcatca ttgaatacga tgcttttgcc cgggcttgat gtggtggctg tatcttctgt 759181 tgtcaggccg aatacggcga ctttctcccc gtcaacgtct aacagaatgt aagggtgaat 759241 gccggcctct ttcttttcac ctgccgtaaa ggtttgcggc tttttgacaa atgatttcag 759301 cttgggctca tttgacacat ctacgtttgc actgacaatc ggaaattccg gcgcttcaaa 759361 gtgatagcgg ttcgccggat caacggttgc gctgtttccg cttagaaaat cagaaagcac 759421 cgtcgggcct ttgtcaaatt catggtttcc gaaggtcatg gcgtcatagc ccatcatgtt 759481 catcattttc agatcggcca aaccgttcca tttagtaaaa tacagatcgc cggaaaacac 759541 atctcccgca tcaaggagaa tattgtgatt tgtttcgctg cgtacttcgt tgattttcgt 759601 cattcgtctc gctgcatcat cgagatgggc gtgcgtatca ttggtgtgca tgacggtcag 759661 atcccacagt ccgtctttag gaggatctgg atttgaatca tcatcgaatt gcagcttata 759721 cacaccatag ccttcattcg cagacttgcc tacataagcg acatcgtctg ctttatcggc 759781 aaatggcttg gccaaaagcg aggattcaaa cgtcagattc gtgccggaaa caggcgcgat 759841 tgaccagttg ttgtctgctt ttggattgac tgttttttgt tcaataatgt aatccatcag 759901 cacctgccta ttttcaactg cagagccgtg gacaatttta tcgctcgtca gatgagggaa 759961 cccgccgcct ccggacgcac gatagttatt ggtgactacg agaaattcct ggcttgggct 760021 gatcggcttg ccttcatagg aaagattgat gatacgggat gaatccgcat tgatcacttt 760081 tccgttctca ttgtatttag ccggttttgt cacatcgacc tgatatgtga caccgtcaat 760141 cacgtcaaaa ttataggagc ggaaattctc gttcagcaag gcctggtcgc cgcctttagc 760201 tggatcaatt tgattgaatt ggcctgctga catctccagc cagtccttga cctcgctgcc 760261 tgtcagcttg acgatttgaa cagtattatc gtaaagatac aagtcaccga catttttaat 760321 cgcaagatct ccggctggaa tgtttgtata gtaattggct ccgtttctgc cgcctgcttt 760381 aaacggcgct ccagcggata aaatcggcag gttcttgtac tcggtatcct tcatttcttt 760441 ttcagcgtac cacttttgcg cgtcagtcac gatctgaatg gaaggatcat ctttgacctg 760501 tgcaaagaag ctgttaatat ctgcttcggt tttgccgact ggctttcgga catactccag 760561 tgtgttttgg tgtgtttgct gaatggtgtt tgtaacggtt tcgtttcttg atgtgacgtt 760621 gccagcaata gattcaatac ttcctttgga atctgctacc ttccatgagc cgtccgcctt 760681 ttcaagcttg aggtcaatca cgcctaaata tttgccccag ctgcttggca tgacgacagg 760741 aatgccgtta attgttccct tttccacatt gaactgagca acacccgcat actcggcgga 760801 aggaaagagt ccgtgctgat ggcccgagat aatcgcgtca atgcctttcg ttttggtggc 760861 aaggtcaaac acggcgtttt ctgcgcctga tgattgcgcc tgcttttcaa tgccggtgtg 760921 ggcgagggca ataatgacat ctgcgccttc cgccttcatt ttcgggatcg tttcattggc 760981 ggattctacg atatcctgca cctgaacttg cccctcgaga ttctttttgt cccatgtcat 761041 gatttgcggc gggacaaagc ctatgtagcc gacttttact ttctgctcat taccgttttc 761101 atcaatgagg gttttttcat taatcacata cggcgtataa cggttttcgc cgctagttgt 761161 tttgacgttg gcatttacaa tcgggaaatc ggctcctttg attgtgccgt cgagaaagtc 761221 gagcccgtag ttgaattcat gattgccaag cgttccggcg tcgtatttca gcgcattcat 761281 gacgctgata atcggatggg ttttcgtgcc ggagataatg tcgtcttttt gatatttcac 761341 cgcgtattca cccagcggat tcccttgaat caagtcgccg ttatccacaa gcagggtgtt 761401 agggttttgc tcgcggtgct tttggatcaa ttgcgctgtt ctcgccagac cgaaatccgc 761461 cgtttctttg tcgctgtagt aatcgtaatc catcatgttg gcatgaatat cagtcgtagc 761521 caaaatactc agatgcacct gaggagccgc gctttcttct gcatgaatgg gtggtgttgg 761581 gaggattagg ctaagtatca taattggggg caaaagaata cggagaatgt tttcgacgtg 761641 tgttcgtctt ttctgtattc tcaccagttc tccacctttc aacgaaattt gtgttacagc 761701 tcctattgta agaatatttt gtaactattt gtaggtgttt ctttatgatt attgtaaaag 761761 ggagaaaaat gagtattatg tagcagtatc aaacgacaaa tactgggcat ttatgcttat 761821 cgtttgtcac aatcgcggaa tgtttatttt agtgtggctg gggtagagtg ttttatgtag 761881 acatataaag cgggaggtta tgaatcatgg ggaaaaaaat tgcagttgtt ttaacatatt 761941 attttgagga cagcgagtac actgagcctg cgaaagcctt taaagaagcg ggacatgaac 762001 tgactgtcat cgaaaaagaa aaaggaaaaa cagtaaaagg caagcaggga acagcggaag 762061 tgacggttga cgcgtccatt gacgacgtaa attcttcaga ctttgatgcg cttttgattc 762121 ctggaggatt ttcaccagac cagcttcgcg ctgacgatcg tttcgtccaa tttacaaaag 762181 cgtttatgac tgacaaaaag ccggtatttg ccatttgcca cggcccgcag cttttaatca 762241 atgcgaaagc gctcgacggc cgaaaagcga cgggctatac gtccattcgt gttgacatgg 762301 aaaacgccgg tgccgacgtt gtggacaagg aagtggttgt ttgccaggat caattggtca 762361 ctagccgcac accggacgat ataccggcat ttaaccgcga gtcattggca ttgcttgaga 762421 aataagaaaa aacggacgct cttgggcgtc cgtttttttg ttgcttaggc ttgagcacct 762481 gtcagtttct tgtacctgta atacaagaaa gcagctgcag ccgttccgat gaccgcaatg 762541 ccgaagtcga atatgaaaat atgggcgatg ccccccgctt ttgcgataag ccctgttgca 762601 atcggcagca gaatcgatgc aagacttgaa gcagtcgcta caattccggt aacggttcct 762661 tttcgcttcc agaaaagctc tgtcattaac gtaatggtaa tttgaaacac acccgcagtt 762721 gaaaagccta agaaaaaggc agtgatgtcc agcacaactg ggatatgaac ggtcagcatg 762781 actgcgagcg tacataaagt aataatagga tataagagcg ttatgaagac aggtttgacc 762841 catctattca gcaaaacggc taataataaa acagatgcca gagatcctat actataatag 762901 ctcagcaatt gtacagatgc tgattcagct aaaccggctg ccttttgcgc gtagctcggg 762961 agccagattt gagaaaccgt aaataaagcc gtggatgtaa aaccgatgat aatcagtgcg 763021 gtgccttcct tctgaaaaac gggttcagac aagaaaacgg gagattcctg ttggccgcta 763081 ttagttggtt tcttatgttt tttaggaaac gaaagcgttg ataaataaat aatattcagg 763141 agatagaccg ctgccggcag ataaaaagca aatccgtaaa acatgctgtg gtctgctaaa 763201 aatgtgatca aaagcggcaa aagtgcggcc cccacagaca taaaggcttt aaccaagaca 763261 tttgccgaac cggaagcaga cggaaagagc tcggttaggg ccggatatgt tccggcatcc 763321 atggctgaat tagcgactcc ggctaataaa gcgaacacaa acgccagctc atagctcggt 763381 gataaaggaa taccgactaa aaagacggcc ataattcccg cagaagcgac aacaagcggc 763441 tttctgccga ttttatctga tagaacgccg gaaatgccgt atgtcagcag tttgccaaac 763501 ccgatagcgg caatgacata actgatgccg gtcggatcgg tattccactg ttttgttaat 763561 gaagacatat tggatgcgag aatgatgttg accatcccca gaaagaagta gttgatatac 763621 attccggatg ctgttttgat agatgtcgtt tgcatgcttg tactccttca aatcttattc 763681 gaacactttg ctgttttggt ttggggaaat gataaaaaag actcgccgag tttccggcca 763741 gtctccatta tttacgaagc gaggctaatt cttgagcaat cgcctgcatt tcacttgggc 763801 tgaatgattc ttttttcatc accattctgt gaaggtacgt gaggtcttca atcttctcat 763861 cactgaaatc ctccgctttg attacgccga cgttcagcat gttcagcttt tgggaaatct 763921 cttcaatcat ttgagttaat gtttctgtat ttgggctgga caaagggttc catcctttct 763981 atgcgcaata taggtatgtt ttattctaac agaattccat cagaaaaaaa ccctattcta 764041 aaagcaggct gttcattcca aaaaagtgaa gacatcagtt gaaaagaaaa tgaacatcct 764101 actaagatat tcatgaaggt ttctttttag agaaataggg gcaaagaata gggaggttgc 764161 acatcatgat aagcgtgtta tttgtttgtt taggtaacat ttgccggtct ccgatggcgg 764221 aagcgatttt tagggacctg gcagccaaaa aaggattaga ggggaaaatc aaggcggact 764281 cagccggtat tggcggctgg cacatcggca accccccgca tgagggaacg caggagatat 764341 tgcgcagaga aggaatcagc tttgatggca tgctggcgcg tcaagtcagc gaacaggatc 764401 tggacgattt tgattacatc attgcaatgg atgcagaaaa tatcggaagt ctcagaagca 764461 tggcgggttt taaaaacacc tcgcatatca aaaggctctt ggactatgtt gaagattcag 764521 atctggctga cgtacccgat ccttactaca cagggaactt tgaagaggtc tgccaattaa 764581 tcaaaacggg ctgtgagcag ttgcttgcat ccattcaaaa agaaaaacaa ttgtgagtga 764641 aaggagaatt tgcatgaaca acgaacgttt aatgctgaaa gggatatttc tcggagctgc 764701 ggcaggcgcg gcgttatcac tgctccataa gccgacaaga caggcgtgcg ggatgagatg 764761 gctgacatgc aagcataaac tttcactgta caaaagcaac ccagagctgt taaaaaacac 764821 tgtcatcaca aaagtggatg aggccaaaaa gctcgcccga acgctttcaa aggaagtcga 764881 ctttgtgaac cagcaggtga aagagctgaa gaaaacaacg ccgcaagtga tggaactcgt 764941 gcaagaaacg aaagagcatt tttcaaaaaa atgatcaaac atgcgaggtg agacgacatg 765001 agttttttga aagagctttt cagcagatac acccttcatg aaggacaaag taaatcagcg 765061 gagctggcgt atttttttct attgtcactg tttccgtttt tgatttttat gctgacgctc 765121 accgcgtatc ttccgctttc taccgatgat gttttaggag tcatagaaca atatgctccc 765181 gccagtgcga tgtcactcgt tgaatccatt acccatcaaa ccttaaataa tcgaaatggc 765241 ggtttgctgt cattcgggat tatcgccgca ttatggtctg cgtctaatgg aatgaatgcg 765301 atcgtccggt cgctgaacca cgcgtatgat gtggaagaaa accgctcttt tatcattgtt 765361 cgtctaacct cgattttttt gacgattgcc atggtattta cgattttagt ggctttgctt 765421 ctgccggtat ttggccggga gattggaagg ctcgcttctg actttgtcgg cgcgtcggat 765481 ctgtttttat ccgtctgggc cgccattcgc tggggtgtca gcccgcttgt gcttttgatt 765541 gttttttccg cgctgtatgt gattgcgccg aacaaaaagc tgtctctccg gtttgtcatg 765601 ccgggtgcgg tctttgcgac tatcggctgg atcattgtca gcacattgtt ttcattttac 765661 gtcagcacgt ttgcgaacta tagcgccact tacgggagca tcgggggaat catcgttctg 765721 atgatttggt tttacttgag cggcatttta attatcctag gcggagaaat caacgctctt 765781 ttacataaac gtaaaaagct tcctgatgaa aatccctacc attagcgcac cctataaacg 765841 aacttcggtt caaaaagaag tcggggggat atcgtgatga ccaagcatac gaaaaaaggc 765901 ggaagccata acaaacaaaa ctcgaaaagc aaatcgagcc ataaaacaag cggaagcgcc 765961 aacggacaaa acggctacca ttagcataaa agcctcctga catgatgtcg ggaggctttt 766021 tgattaagaa gatgaagaat aggtttcagc cggtgaccag cttttcggtt tgcccagcac 766081 aagggccagc cacacagagc taagcgtgag agtaatgaag tagaacaagt ttgcgctttc 766141 aaatgtctgc atataccagc cgccggcaac tgggccgagg atgctaccga gactgaatgt 766201 aatgccgcaa agcaggtttc ccgccggcag gaggtgaggc ggaagaaggt ctgtcatata 766261 gctgatgcca agtgtaaagg ttgatccgac tgccattcct gcaataaaaa agcagccgcc 766321 gatcacgtag ggcgaaggaa atacaccggc gatgaaaaag caaagagccc cagtcagtaa 766381 aatcaccagc agcacattcc gcctgccgta tttatcgctg aggatgccga gcggaaactg 766441 aaagataatg cttccaatcg caaatgcggg aaggatgatc gctactgcgt ctactgatat 766501 ccccaaacgg agcgcgtaca ccggaaagct tccgttcagc gccgtttcca gaaagccata 766561 gccaaatgta ggcataaagg caacccaccc aaacagcatg gcctgataaa atcgcctgaa 766621 actattgtct gatttggttt catgaggact ggtttccggg tatgcatttt gtagaaagaa 766681 aacaaaaagc cacgcaaaca gactgatgca gccggacacg ataaaaggaa gcgacggact 766741 cagcttgaca agcggcacca tgaacgggcc tgcggcaaag ccaaggccaa aggaaagccc 766801 ataaatagac aggtttcttc cgcgattttg ttttgatgac atggaggtca cccacgtttg 766861 cgtagaaaag tgaagcatgt ggtcgccgat tccaatgaac aggcgaagca ggaaccagac 766921 ccaaactgac tgaagccaaa taaatccgaa taagcttaaa atgacaatgc ttccgcccat 766981 gacgatcagc ggcttgaacc cgagctttct gagcggtgct tccataaacg gcgaagccaa 767041 aagcacaccg atatacagcc cggtcgcgtg caggccgttg atagcagcgg attctccatt 767101 tgtttcaaaa atgattgaaa tgacaggcag cagcatgcct tgtgaaaacc cggaaatgga 767161 aacgagcaag acaaggataa agaaatgaaa tcgtgacatc gtgtcagttc tccttatatg 767221 gaatctatgt tgatcgtaca acgttttcca aaagcaggca acctgaaaaa agcctatatc 767281 acgctataca tttgccctcg tgtaatcatg aaggtttttg tgaagaataa aaataaaaca 767341 agtcataaaa aaggagctat ttcaccatga atcgtatctt ttttatttta gtggcggccg 767401 gtgttccgct ttctgtgatt ggcagtttga tgcattggcc ttccgcggtt ctatttgcag 767461 tttattgcgt gacgattatc gcgcttgcaa gctatatggg gagggcgaca gaatcactgt 767521 ccatcattgc aggaccgcgt atcggcggtt tgttgaatgc aaccttcggg aatgcggtgg 767581 agctgattat ttcccttttt gcattaaaag aaggcctgac aggaatcgtg cttgcctctt 767641 taaccggttc agtgctgggg aacctgttgc tggtagcggg cctatcgttt tttgtcggcg 767701 gtttaaaata taagcggcag gaatttaata tccatgatgc ccgccataac tccgggcttc 767761 tgatttttgc catcattgtc gcctttgtga ttccggaggt attctctgtt ggtatgggaa 767821 acgccagcaa gctcaattta agcatcggca tcagcatcat tatgattctg ttatatgtgg 767881 cggcgctgta ctttaaactt gtcacgcatc ggggcgttta tcagccgaat aatgccgctc 767941 agactgaaga agaggaagag ccagaatggt cagggaaggt tgcgacgatt gtcttgtttg 768001 cggcaacgat tgtggttgca tacatatccg aaaacctggt ccataccttt cactcggtgg 768061 ctgaacagtt cgggtggagc gagctgttta ttggggtcat catcgtggcg attgtaggaa 768121 atgcggcgga gcatgcgtca gcgattatta tggccttcaa aaataaaatg gacattgctg 768181 ttgaaattgc agtaggctct acgctgcaga tcgctatgtt tgtcgcaccg gttctcgtca 768241 tctgttctat cttttttccg acaagcatgc cgcttgtatt tacattgcct gagctcgtcg 768301 cgatggtatc agcggttctc ttgatgatcg cgatttcgaa tgacggggat tccaactggt 768361 ttgaaggggc gacactgctt gctgcatatg tcattatggc gatcggcttt ttccttcttt 768421 aacctgaaaa aatgatggat aacaacaaag cgggatgaaa agactaaggg aaaatgccat 768481 agaaagagtg atatgatgaa aaagctattt cattccacac ttattgtgtt gttattcttt 768541 agttttttcg gcgttcagcc catccacgcg aaaaagcagt ttaaggttcc taattctgtc 768601 gcaagcattt caaaggaaaa cacgtatccg aatgcttcac aggatcagcc aatgcttcag 768661 ccgagcaagc tggcaaagga attgctcgat cattctgagg taaagattga aaatccgcat 768721 ctcatcaaaa tgctgaatga atccaacata tccggcacac cgcttgcagt agggtaccgg 768781 gcgacaatat ttctcgggaa atgggcgctc ggctatgaat caaatgaaac agtcgcaaac 768841 tgggaatata aaaaaatcaa tacaaaccgt gcggataacc gcggcgggaa agaaacggct 768901 gaaatgcatt atgcccagga acagcagtac agagtgaagg gcggcttgac agctaaagtt 768961 ccaaatgctg aagatgtcaa aagcatgatg atgcaaaaag caatgaagaa aacgaacctc 769021 ccgcttgcat ttgagacggt catcggggct ggcacaaaac gggatcagat ttataaagtc 769081 gctcctaaaa aaatcggtta tctacatgca tatgcaccgg ctgtgaatga aaaaggaaaa 769141 gtgacttacg gagaagtgta cttagtgctg aaaggaaata aacgaaaact cgtcgtgaaa 769201 aatgtcacgt cacagggaat cggcgcgtgg attccggttc aagatcatgt cacgtttggc 769261 tttcagcttt cctcactgcc aagataaata aaaaactgat tccaactcgg aatcagtttt 769321 tttgtttatt gggttctctc gattcggacc gcttcctcaa gcatttgcac attgttttgg 769381 tagagctggc gaacgagaac ccgtcttact gcaaggctgg cactgaaata atcatcatct 769441 ttcaccatgc ctttaaccgt aaattcgacg ccgcgattga ttttattcaa tgcggtgatg 769501 ccgtggattt gaaacggttc tgtcggattg ccgaattcat cccgcttcaa tgaatcacga 769561 agctcttcat tcagcatgtc acatgcctct tccaacacgc tgtacacgcg gtccggatct 769621 tctttaaagc tgataagaaa ggattcggta atccgcataa aatcaatatt atagttctct 769681 atttgtctga cctcgccgtt gctgatggtg agcagcttcc cgctccattc ccggatttgc 769741 agcgagcgga ggccgatttc ctccactgtc ccgttgaaca agttgttgac ggtgacataa 769801 tcgcctttgt gcagctggcg ttcatatatt aagaatacac cagccagcac atctttgatc 769861 agcgattggg cgccaaaacc gatcacgata cctgctacgc ccgccccggc caatatcttg 769921 ccgaaatcat gcacaaataa agaaataacg taaaagataa aaccaattgt tgccgtatac 769981 tgggtgacag aacggacaag gctttcaatc gttttttcct ttttttcttc aataaagtcc 770041 gtccgtttaa aaaatagctg taccagccgg ttgatgataa agacaccgat ccaaaggata 770101 acggcaacga ggagaatatc gacgatttta ttttgaaaaa tctccgtaag tgtttctttc 770161 atccgcatct aactcctggc ttgacgtttt gtgaagtctg tatcctgata ataactgttt 770221 ttgacaagaa cattcggtcc gaggcaccgg acattcgggc agtggcaact cagttctttc 770281 gcaagcttgg tctctctcca cttttcatag gcggaaggga ggctgtccgt ctgaatgttg 770341 ccaagcggcg gggtatcacc gaaatcggtc acgataatgt ttccgtcgaa aatgttcaca 770401 ttcaggcggg atcggccgtc agggtcattt cgcactgtga cgtttttcgc cgcgcgaagc 770461 cggcgaagca gcttttggtc gtcttcgtcc ggactgcagg cataaaacgg cagcgttccg 770521 aacagcatcc acgtattttc atcacgaata tccagcaagc ggtgaatggc ctgtctcatc 770581 tctttcaggc tgagggattc aagagcgctt gcgaaatcgc ttggatacat tgggtggacc 770641 tcgtgacgct gacatttcat atcttctgtg atttggcggt gaatatgctc aatatgcgga 770701 agtgttcgtt tgttcagcat cgtttccgca gataccatta ctccggcatc cacgagcgtg 770761 cggctgtttt cgatcatttt ttcaaaatag cgcgcgcgct gttcgaaggt cggttttctg 770821 tccatcatgg caaagccgat ttcagcaaaa tcttcaactg ttccccagtt atgtgaaata 770881 tgtagcacat cgagatacgg aatgatccat tcgtaccgct cgatgtcgag ggtcagattt 770941 gaattaattt gtgtccgcac accccgttca tgggcatatt tcaataaagg aacaacatat 771001 tcttttactg atttcaacga aagcatcggc tctccgcctg tgatgctgat ggatctgagg 771061 cgcgggattt cctccagccg ttttaacaga agatctattg gcagagcatt cgggtcttta 771121 ggctgcaatg tatagcctac agcacaatgc tcgcatctca tattgcacag tgtcgttgtt 771181 gtgaattcaa cgtttgtcag ctgcatgtct ccgtattggt caacatccat ataggcttcc 771241 caagggtcaa actcgggcgt aatcggacgc agcttcgtgt tttgtgtcat gactatctaa 771301 ctcctttata aatgggcata ctaacgctgc caacagttaa ttttagacct gatttgccaa 771361 gatcgcaagt agcgcggcga ttgaaaaacg gcaaaaaatg agctaccata ataaaaaatg 771421 aatggaggaa cagaatgggg aacgccgtaa acaataaaga tcagcagatt gattatttaa 771481 agaacagact tgacatgttt atgaacgtca tcgattcatt agaccctgaa gcaaccgacg 771541 ttgaagatat agacaggctt atcagcatgc ttgatgacct ggaagccaaa tacgaacgtt 771601 ttaaaaaaga ttgggaataa aaccgcgtgc ccgccgcggt ttttttattg gcataaagca 771661 acagtataaa acaaagtctc tatctgtaaa ataagaaaaa atgcagaagg agcgctggcc 771721 atgaagtgga tgtgttcaat atgctgcgcc gccgtattgc ttgccggagg tgcagcacag 771781 gcggaagcgg tgccgaatga gccgattaat tggggcttta aacgaagtgt caatcatcag 771841 ccgccagatg ccgggaagca gctgaacagt ttaattgaaa aatatgacgc gttttattta 771901 gggaatacaa aggaaaaaac gatttactta acgtttgata acggatatga aaatggctat 771961 acgccaaaag tgcttgatgt cttaaaaaaa catcgcgtaa caggaacgtt ttttgtcacc 772021 gggcatttcg taaaggacca gcctcagctg atcaaacgaa tgtcagatga gggccatatt 772081 atcggcaatc attcctttca ccatccggat ttaacgacaa aaacagctga tcagattcag 772141 gatgaacttg attcagtcaa cgaagaggtt tataaaatta cgggaaagca ggacaacctg 772201 tatttgcgtc cgccgcgcgg cgtgttcagt gagtacgtac tgaaagaaac gaaacgcctc 772261 ggctatcaaa ccgttttctg gtcggtcgct tttgttgatt ggaaaatcaa caaccaaaag 772321 ggaaagaaat atgcctacga tcatatgatc aagcaggcgc acccgggagc catttacctg 772381 cttcacaccg tatcgaggga caatgcagaa gcgctggatg acgcgattac agatctgaaa 772441 aaacagggct acacttttaa aagcattgat gatctgatgt ttgagaaaga aatgaggctg 772501 ccgtctttgt aaaagagaaa gacctctcct taaacggaga ggcttttctt tattttatac 772561 atttaatcag tgcggcccag tccagatccc cgaagccttt ctcaatcccg ctttcaaaat 772621 ggctcttggc cagctcggca agaggaagat ttgcagaaac ccgttttgcg gcggcgagtg 772681 ccaggttggt atccttcagc cctaaagaca ttttgaagcc ggccggctca aatttctgct 772741 cggccataat ggttccgtaa ttttgataga ctggagaacc aaagagcgcg ctggcgattt 772801 ctaaaaattg tttttgttct aagccgtatt tctccatcat taaaaaggat tcagataacg 772861 cctccagcat ggacacaagc aagaaattaa tgctgatttt ggctgcattt gccgtcttgc 772921 tttcttcgcc gacgtcaaat atctgctggc tcaggctgtc gagcagaggc ttggcagctt 772981 gctttgcttc cgccggtccg gctgttatga tacggagcgc ggctttggct gcggcatccg 773041 gtctgccaag gacaggagcg gcgagaaaaa attgtccttt ctctgcatga gccgctgcga 773101 gcttttctga gaactcaaca ctgattgtgc tcatcgagat gtgtatgccg ttctctgcta 773161 atccttcaag cagcccgtct tctccgaatg tcacggtgct gacagaatca tcatctgcaa 773221 gcattgtgat gacaatatca gcggactttg ccgccagccg cggcgtatca gctgcctgtg 773281 cgccttctgt gacaaggtct tctgtctttt gtttcgtccg gttatagaca gtcaattcgt 773341 agcctgcttg aagaacattt cgggcaatgg gctgtcccat attgccgagt ccgatgacag 773401 caattttcaa tctaatcact ccctgaatat tttttccatt ataaacaata tgaacagaat 773461 atgcatagcg atcggcttac aacaaaaaag aacagctgct cgctgtcctc atttaaaaat 773521 attgaaccat cctttatgta caaaccaaat cagcattcca atcacaagcg cggccatcag 773581 gccaagtaca gcgaaatatc cgtatttcca atgcagctcc ggcataaagt cgaagttcat 773641 accgtataca ccggcaataa aggtgagcgg gatgaaaatg gttgatacga tcgtcagtgt 773701 catcataatc gcattcatcc ggtttgagtt tagcgtcacg tagctgtcac gcaagtcgga 773761 cgtcatgtca cggttggatt ccacaatttc agacaacttt aacaaatgat catatatgtc 773821 gctgaaatag gctttcgttt cccgctgctc tttcacatgg tcaaggctta aaatccggta 773881 gagcaaatca cgcatcggga taatcgtccg tctcaaatgc aataggtctg ttctgagatc 773941 aaacacctcg ttcatcagcg ttccatacgt tttgtgggga cggctttctt caatttcatt 774001 cagccggtct tcaattttat acacgagagg aaaatattca tcaacaagct gatccatgat 774061 catataagaa atatgcccgg gccctttttt caatatgtcc ggtgaagcat acaaacgctc 774121 ccggacttta gcgataccgg gcgtttcgtg taaatgaaag gtgacgacaa atttttcgcc 774181 ttgaaagata tcgacttcct ccgtctcaag tgtttcctta ttcagcgcat gaatcacgta 774241 aaaacgatag ccgtcataat ggtcaagctt tggccgctgc atatgctgga agcaatcctc 774301 aatggcaagc gggtgaaaat gaaaaaaatc tctcaataac gccgtttccg tatcctccgg 774361 gccgtaaaaa tcaacccagt accatgcaat atcaggctgt tccactcgtt cgatcggtat 774421 atttttcagc agctgatgct ctgttgtgat tgcggtaatg ttgatcataa acaaccctcc 774481 acctgccatt atatcatgcg gtctttatga gaaaagtata cggtactctc tgcctaattc 774541 cagcggcatg ttatactgaa caaaaacgga aaaaagggtg gatctcatgt ggaaggaaaa 774601 agtatctgtc acgcctccgt atcattttga ccgcgtgctg gacaggctgt ctttagaccc 774661 cctcaatgct gttgatcgag aggcgaggga agtccgtgtg ccaatcagaa atcaagcggg 774721 ggacgtatgt attgtaaagg tacaggcgtt aggccatgcg ggcgagcctg agttcctcgt 774781 cagcggggaa acggatcagg gagaaatgat gaaggaaatc aagcggattt ttcaatggga 774841 aaatcatttg cagcacgttc tggatcattt ttcaaaaacg agcctgtccg ccatttttga 774901 agagcatgcc gggacgccgc ttgttctgga ctacagcgtg tacaactgca tgatgaaatg 774961 cattatccac cagcagctta atctttcctt cgcttacacg ctaacagaac ggtttgttca 775021 tgcgtttggc gagcagaagg atggcgtgtg gtgctatcca aagccggaaa cgattgcgga 775081 actcgattat caggatctgc gtgatctgca attcagcatg agaaaagcgg aatacaccat 775141 tgatacatca aggatgatcg cagaaggcac actcagcttg tcagagctgc cgcatatggc 775201 ggatgaagac attatgaaga aactgatcaa aatcaggggt atcggcccgt ggaccgtgca 775261 aaacgtcctc atgttcggac ttggccgtcc caatttattc ccgcttgccg atatcggcct 775321 ccagaatgcc atcaaacgcc actttcagct ggacgataag ccggcaaagg atgtcatgct 775381 ggcgatgagc aaggagtggg agccttattt aagctatgcg tctttgtatt tgtggaggag 775441 tatagaataa ttcgtctgac aatgaaggaa atcctgcaaa cgtgttatac tagaaagatg 775501 tgaaaaaacc atttcacttt ctgccatccg cagaaagctt catatagaaa cggagagaac 775561 aacgtgaacc aacaaaagaa acaggcgccc gtcgaactga aggtcggaca aacttttccg 775621 ctgacgatta agcgtctcgg cattaacgga gaaggtgttg gctattttaa gaaaaaagtc 775681 gtcttcgtgc ccggcgcgct tcctggcgaa gaagttgttg tgcaggccac aaaggtccag 775741 ccgaagtttt cggagggccg cattaagaaa atccgcaagg catctgagca ccgggtggca 775801 ccgccttgcc ctgtttatga acaatgcggc ggctgtcagc ttcagcacct tgcatacagc 775861 cagcagcttc gggaaaaacg tgatatcgtc attcagtctc ttgaacgcca tacgaagttt 775921 aaagttgaaa acatggaaat caaagaaacg attggcatgg acaacccgtg gaattaccgc 775981 aataaaagcc aattccagat cgggcgctcg caaagcggca gcatcatcgc cggcttatac 776041 ggccttgatt ctcatgatat cgtgccgatt aaagactgta tcgttcagca tccggcaacg 776101 aacaaaacaa caggcatcgt ccgccgcatt ttagaggact tcaatgtgtc tgtttataat 776161 gaaagaaaac gaaaaggcga cgttcgcacg atcgtgacga gagtcggctt tgaaacaggc 776221 gaagtgcagg tcgtgcttgt aaccgcaaaa gaaacgcttc cgcacaagga agaaatcgtc 776281 aaagcgattc aaaagcgatt gccagaggtc aaatccatta ttcagaatgt aaacggggcg 776341 aaaacctcag tgatttttgg tgagaaaaca aaacagctcg ccggaaaaac agtgattcaa 776401 gaagtgctcg gcgacgtatc ttttgaattg agcgcccgcg ctttcttcca gctcaatccg 776461 gaacagaccg tcaagctgta tgatgaagtg aaaaaagcgg cgcagctgac cggaaaagaa 776521 aaagtcgttg atgcgtattg cggcgtcggc actatcggca tgtgggttgc ggacggagcg 776581 aaggaagtcc gcggcatgga cgtcatcaag gaatcaattg acgatgctaa gaaaaacgcc 776641 aaaaaacacg gcatggcaaa tgccacatac gtaacaggaa cagccgagca ctggctcccg 776701 aaatggacga aagaaggctt ccgcccggac gtcgtcattg tagacccgcc aagaacgggc 776761 tgtgacagca cgttcttgga cacgatcaaa aaagtcaaac cgaaacgctt tgtctacgtt 776821 tcctgcaatc catccacgct tgcgaaagat ttgcagacgc tgtcgaagga ctatcgcgtg 776881 gactatattc agcctgtcga tatgtttccg cagacggcgc atgttgaagc agtggcgagg 776941 cttgtattaa aatcgtctaa ctaaaaagaa catttcccag tcataaaata gttttcctaa 777001 taagacctgg atttcggtaa aataaacaat tccgatttcc gggtcttttt cgtgcgcagc 777061 tcttgtccta acggtctgtt ctcaatttta tcttccttct tttcgcggag atctttattt 777121 taactggcga aaagaattga aaaaacgtgt tgaaaagcag gtgaaaaaaa gcgttattta 777181 accggaaaaa tatcctccca gtatgtttaa aatacatgag tagaatgatg taaaatcata 777241 gatgtatttt cataatttgt aaaattatat attgacttgc agttattacg tgtgaaatat 777301 tgatgatagg aatataagga aagtatggcg tatatcattt caagagtcat tcgatgtaaa 777361 aagttgaaac attgtaataa atgaaagagg tgaaaatgat ggccaacccc attttaaaat 777421 gcataacgta tgagcactac aacaattaaa taatagtgcc gagacgataa caactattac 777481 agtaatacct acaatggtta tatccttgcg acaatcatgc ttcataatat aatgatttta 777541 gattgacact tggctaaaaa gtattgcaga gaaggaaatg gataattaaa tggataaagt 777601 atataaaaga agttggtttc aaacattttt ggcattttta gtatctcagc tttattttaa 777661 ttttgtagaa ttaacgggat ggggtcctaa gtatagagaa atgaatggat tcccagcaaa 777721 catagttgaa ctagatttct ttcaaacata tctttcattc tatgataatc catggtttaa 777781 tattattact gttttcttgg gagttttcac tattatacaa ataattacag ggataacaaa 777841 ggatattcga aattaaagca ataacttctg atgccttatt taatgatgaa agaaaatgta 777901 cactttctta attatcttat gagtgaagac tgcgacactt agtcagcagt ctattttatg 777961 gttctggatc aggattaccg aattataacc ctatacaaat atatagtagg ttgccacttg 778021 ctgcgttggt tattttctaa atcatgagca aatcccaaat gattcagatt gaagttcttg 778081 aattctttta aataagggtt tattttctct tctcatcctc tttactccat gtgattcaca 778141 agtggtagca gcttaagtag gttttttcat tctcttgagt actcagttat accaccccca 778201 actcaatttg ctttatctct attagttttt ccgcaaatat gatatagaga tacggatatg 778261 gtgtagtgtt aaatatctta tcttcaataa cagggcaatt attttgcgtt ggtaatatgg 778321 agaactcata tgatattcta tttaggttgg aatccttttt atccaaaaag ttcaaaagca 778381 aggccactaa gaaagacgaa ggtcagcgcc agttaaccag aatataaaaa atagggtaga 778441 taatcatccc acgtgaaatc ttcaaaattt actatagatt gataagaaat gctttcgcat 778501 gcgataagtg taaaagaagc atggtcagtt tttaatttgg gataaaggtt cagccgtatc 778561 ccataatgaa aggatttgat ttttgttatg acagaaaatt tctggcgtga attaccacgg 778621 ccgttttttg tactggcacc aatggaagat gtgacagatg ttgttttccg gcatgtagta 778681 agtgaagcag gcagaccgga tgtgtttttt acagagttca caaactcaga gagctattgc 778741 cacccggatg ggaaggatag cgtgcgcggc cgtttgactt ttacagagga tgaacagcca 778801 attgtggccc atatatgggg agataagcct gaaaacttcc gtaaaatgag tattggcatg 778861 gcagagttag gatttaaagg actagatatc aatatgggct gccctgtgcc taatgtggcg 778921 gggaatggaa agggaagcgg ccttatttgc cgtcctgcag ttgcggcaga attaatacaa 778981 gctgcaaaag cagggggatt gcctgtaagc gtgaagacaa gacttggata cacggatgtg 779041 gatgaatggc gcgagtggct gacacacatt ttgaaacagg atattgcgaa tctttctatt 779101 catctgcgta caagggcaga aatgagcaaa gtagatgcgc attgggagct catcccagag 779161 attaagaaac ttcgtgacga ggtggcacca gatacattgc taacaataaa cggggatatt 779221 cctgaccgtc aaactggctt gaaacttgct gaacaatacg gcgtcgatgg aattatgata 779281 gggcgcggta tttttacaaa tcctttcgct tttgaaaagg agccgaaaga gcatagcagc 779341 aaggaattgc ttgatctctt aaggctgcat ctggatctcc atgatgaata ttcaaaagaa 779401 gaagcccgtc catacaagcc tcttcctcgc tttttcaaga tttatctccg cggattccga 779461 ggggcaagtg aattaagaaa tcaatgcatg aacacaaagt caacagatga agtgcgtgca 779521 ttgctcgacg actttgagag aaagtatctt gatgggatag agtaacagca gtgcttgatt 779581 caaaaaaggc taacaaaata aagggatttt tacacaattc ttgactaaaa taaacctgga 779641 ttttcggtaa atccgggtct tttttgtacg cagcttttac tcagcctgtc ttttctctaa 779701 tttattgtaa gaaaataatg gtatatttag tggagatatc atataaaggg ggagaggaaa 779761 atgaaacggc tatgcatcat cccctgcggc aagaaaaaaa tctgggatgt ccagcctgat 779821 gccgggccgg taagagcaga ggacgcttat ctcagcccgt ttcatcaggc gtgcgagcgg 779881 tatgcaaaaa catttttcga tgagtgggtg attttgtcgg cgaagcacgg gttcctccgc 779941 cctgatgatc tcgtttcggg aaattacgat gtcacttttg gcaccggtca tccggaaatc 780001 atgacagcgg acgagctgcg ccgtcaattt cacgaaaaag gcttttctga tatcgaagag 780061 ctagtcatgc ttggcggaaa aaaatatcga agcgttctaa acgccgtcat cggagaacac 780121 cagcatatca gctggccgct atcatcatac aaaggcatag gctatatgct ccaagcgctg 780181 aaccgggctg ttgaagaaaa gcatgaactg tagcacgtac atatgaggaa aagagtggga 780241 acatgaaaaa acttgtgttt ggcttgcttg ccattgtgtt attcggatgc ggactatata 780301 tctatcatgt atggttcggt gatccatttt cgaaaaatgc tgcagaacag aagctagtgt 780361 cttatgtgaa acaaacctat cctaagaaag aaatcaagat cacgaatggg gtatataacg 780421 ctaaaacgtc tgaatatgta tttgaagcaa cctcccaatc tcatcgctac ccaatgtgta 780481 cgaagggatt tctgcatcct aaagtaacgt gcgatggaat tgaagaagcg tataccgaat 780541 cagtagcaaa acatgtaaat gaagaagcaa cgaaggcaat cgaagcagat ctgaaaaaag 780601 cggttcctcg atttataaaa gctgatgctg ctttgagtat cgaaaacgga cagttcacgt 780661 tagatacaaa atggaacaaa aagctggctg aaaaagcgcc tatgagcatg acgattcagt 780721 tagacgccag cgggttatca aaaacagatg ccgcaaagat ggcggaaacg gtcagaaaaa 780781 cgcttaatga aaagggatat acatactcaa acggcacgat agactgtatg cagaaggacg 780841 gggacggcgg tattggatat gtcaaatatt caattgattt tctttcaaaa gcagctattc 780901 agtcaaacga tgcagaggaa ctaggaagtt aaaaagattt ccaaggaaat aaatacgtcg 780961 atcattgtca aaggccgggt gatatccggt cttttttttg catgctgtaa aacgagacaa 781021 atgaatcagt ttgagacaaa acgagacaca cgtctcaaac tgtctccaaa gtgaagatga 781081 gaagactgat tttacgggct caaaagactg gcacacttct tgcatttata atggtgaacc 781141 ctaaatagaa ggaggcgcac aaaatgaaat tgttaaaacg agaaggcttg tcattaactg 781201 aggaaaaagc gctgtggatg taccaaaaga tgctggagat caggggcttt gaagacaaag 781261 tgcatgaact gttcgcccag ggagtgcttc ccggattcgt tcatttatat gccggtgagg 781321 aagccgtggc tgtaggggtg tgcgctcatt tacatgatgg cgacagcatt acaagcaccc 781381 acaggggaca tggacattgt atcgccaaag gctgtgacct ggacggcatg atggcggaaa 781441 ttttcgggaa agcgaccgga ttgtgcaaag gcaagggcgg ttctatgcac attgcggatc 781501 ttgataaagg catgttaggc gcaaatggaa tcgtcggggg cggctttacg ctcgcatgcg 781561 gatcagcgct cacggctaaa tataaacaga ctaaaaatgt aagcgtttgc tttttcgggg 781621 acggggcaaa taaccaaggt accttccacg aagggctgaa tttagcggct gtatggaacc 781681 ttcctgtcgt atttgttgct gaaaacaacg gctatggcga agctacccca tttgagtacg 781741 catcagcctg tgattcaatc gccgatcggg cggctgctta taacatgccg ggggttacag 781801 ttgacggcaa agatatttta gcagtttacc aggcagccga ggaagcgata gaaagagcaa 781861 gaaacggcgg cggcccgtct ttgattgaat gtatgaccta cagaaactac ggccatttcg 781921 aaggagatgc ccaaacctat aaaacgaagg atgaaagagt tgagcacctt gaagaaaaag 781981 atgccattca aggttttaaa aactaccttt taaaagaaac agatgctaat aagctgtcag 782041 acattgaaca gcgtgtcagc gaatcgattg aaaaagccgt ctcgttcagc gaagacagcc 782101 catatccaaa agattcggag ctgctgacag atgtgtatgt gtcatatgaa aaaggaggaa 782161 tgtaagagat ggcgagagtc ataagcatgt cagacgcgat caatgaagca atgaagcttg 782221 cgatgagaaa agacgaaaat gtgcttttga tcggtgagga tgtcgccggg ggagcggcgg 782281 tcgatcattt gcaggatgat gaagcatggg gcggtgtatt aggggtcaca aagggactcg 782341 tacaggaatt cgggcgtaca agagtgctgg acactccgat ttctgaggca ggctatatgg 782401 gagcggctat ggctgcggca tcaaccggtt tgagaccgat tgccgagctg atgtttaacg 782461 attttatcgg cacgtgcttt gatcaggtga tcaaccaagg ggcgaaattc cgttatatgt 782521 tcggcggaaa agcgcaagtg ccgattaccg tccgcaccac atacggagca gggttccggg 782581 ccgctgccca gcattcacaa tcgctgtatg gccttttcac gagcatccct ggactgaaga 782641 cagttgttcc atccaatccg tatgatgcca aaggtctttt gcttgcagca atagaagata 782701 atgatccggt gtttttcttt gaagacaaaa cgtcctacaa catgaagggc gaggtgccgg 782761 aagattatta tacaattccc ctcggaaaag cggatatcaa acgcgaaggc aatgatgtta 782821 cgctctttgc agtcggcaag caggtcaata ctgcgcttga agcggctgca cagctttcag 782881 agaggggcat cgaagccgag gtccttgatc cccgcagtct gtctcctctg gatgaggatg 782941 cgattttcac atcgttagaa aaaacaaacc ggctgatcat cattgatgaa gccaatccgc 783001 gatgcagcat tgccacggat attgctgcgc ttgtcgctga caagggcttt gatttgcttg 783061 atgcgccgat taaacggatt acagcgccgc atacaccggt tccgttttca ccagtgcttg 783121 aagatcaata tttgccgaca ccagataaaa ttgtcagcgt cacgcttgaa ttgcttggcg 783181 agccggcatt gaattaaagg ggggacacaa atggcggtaa aagtagtgat gccaaaattg 783241 ggaatggcca tgaaacaagg ggaagtatcg atatggaata aaaaagtagg cgacccggtt 783301 gaaaagggag aaagcattgc cagcattcaa tcggagaaaa ttgaaatgga gatcgaagcg 783361 cctgaaaaag gaacgctgat cgatatcaaa gtgaaagagg gagaagaggt tccgcccggc 783421 acagctatct gctatatcgg ggacgccaat gagtcggtgc aggaagaggc gggggcgcct 783481 gttgctgaag acaatatgcc gcaagccgtc cagcccgtca aacaagaaaa caaacccgca 783541 gcctccaaaa aagatcgaat gaaaatatct ccagtcgcca ggaaaatagc agaaaaagca 783601 ggattagacc taaaacaact gaaaggaact ggaccaggcg gacgaatcgt gaaggatgac 783661 gtaacaaagg ctcttgctga acagaaaaaa gatcaagcaa agcctgtttc ggagcagaaa 783721 gcgcaggaaa tcccggtgac aggcatgaga aaggtcatcg ctgcccgaat gcaggaaagc 783781 ctggcaaaca gcgcgcagct gacgatcacg atgaaagctg atatcaccaa gcttgccact 783841 cttcaaaaac agctttcacc aactgcggaa gagagatacg gcacaaaact gacgatcact 783901 cattttgtct caagagccgc cgttctcgct ctgcaagctc accctgtgct gaacagcttt 783961 tatcaaaatg agcgcatcat cacacatccc catgtgcacc ttggtatggc tgtagccttg 784021 gaaaatggct tagtggtgcc tgtcatccgc catgctgaaa agctatcgct gattgaactg 784081 gctcaatcca tctcagaaaa tgccaaaaaa gcacgcgagg gacgtgcggg aagcgaagaa 784141 ctgcaaggat ctactttctc cattacaaac cttggcgcgt ttggagttga gcatttcaca 784201 ccgatactaa atccgccgga aacaggcatt ctcggcatcg gagcaagcta tgacacaccg 784261 gtgtatcaag gggaggagat cgtcagaagc acgatcctgc cactcagcct gacatttgat 784321 cacagagcgt gtgacggcgc ccctgccgct gcattcctga aggcgatgaa aacatatttg 784381 gaagaacccg cagcattaat tttataggaa aagcaggtga aaacgacatg acattagcca 784441 ttatcggcgg cggacctgca ggctatgcgg ctgcggtttc cgcggcacag cagggcagaa 784501 acgtgctgct cattgacaaa ggcaagcttg gggggacctg cctgaatgaa ggctgcatcc 784561 cgacaaagtc tttgttagaa agcgcaaacg ttcttgataa aatcaagcat gccgacagct 784621 ttggaatcga acttccggca ggtgcgatat cagtcgattg gagtaaaatg caaagccgaa 784681 aacaacaggt tgtcagtcag cttgtccaag gcgttcagta cctaatgaag aaaaatcaaa 784741 tacaggttgt aaagggaaca gcctcctttc tttctgaaag aaagctcttg atcgaaggag 784801 aaaacggaaa agaaatcaga gaggcggacc aagtattgat tgcctccggg tcagagccaa 784861 tcgagctgcc ttttgcccca tttgacggcg aatggatcct cgacagcaaa gacgcgcttt 784921 ctctttccga gattccgtct tcactagtca ttgtcggcgg cggtgtcatc gggtgtgagt 784981 atgcagggct gttcgccaga ttgggatcgc aggtgaccat cattgaaaca gcggaccggc 785041 tgatcccggc tgaagatgaa gatattgccc gtctctttca ggagaaactt gaggaagacg 785101 gtgtcgaagt gcatacttca tccagattag ggcgggtgga tcaaacggcc aaaacggcaa 785161 tatggaaaag cggtcagcga gagtttaaaa cgaaggccga ttatgtgctg gtggcgatcg 785221 gcagaaaacc ccgtcttgac ggattgcagc tggaacaggc cggagttgat ttttctccaa 785281 agggcattcc ggtgaatggg cacatgcaga cgaacgtgcc tcatatttac gcgtgcggag 785341 atgctatagg gggcattcag ctcgcgcatg ccgctttcca tgagggcatc atcgctgctt 785401 ctcatgcttc cggaagggat gtcaaaatca atgagaaaca tgtgccgcgc tgcatctata 785461 cgtccccgga aatcgcgtgt atcggaatga cagaacgaca ggcaagaagc atatacgggg 785521 atgtgaagat cggcgaattt tcattttccg caaacggcaa ggcgctcatt aaacagcaag 785581 cggaaggaaa ggtcaaaatc atggctgaac cggaattcgg cgaaatcgtg ggtgtctcga 785641 tgattggccc ggatgtaacc gagctcatcg gccaagcggc agcgatcatg aatggtgaga 785701 tgacggcaga tatggcggag cattttatcg ccgcccatcc gactttatcg gaaacattgc 785761 atgaggcgct gttaagcacg atcggccttg cggtacatgc ataataaagg aaaaagcagg 785821 cgcatggata taaggcgcct gcttttttat tgttgaaagc gctttatttt tcccctacaa 785881 tagatgaaaa cggcgtgtaa gggaggagcg atcaaggaaa tgaattcggt cccaaacgat 785941 ttgcaaacct ggaaacgttt tgtgaaagac ggtgtgcttg acgaagcccg attaagaaaa 786001 cggattgcag agtcatggca tcgctgcaaa aaagctgagg tcaatcctta tttagaaaaa 786061 ggcccgaagg ttttacagca aacggagctg gatcagcagt caaaaaaaca ttcattcttc 786121 ttgacgaccg caaagcctta cctcgaaaaa ctgctgcctg ccataaaaga aatggaaatg 786181 atggcgctgt taattgattc agacggtgtt gttctggcat tggacggcca tccgcgcgcg 786241 ctctatgaag ccaaacgcat caatttcgtc gaaggggcat gctggacaga aacggctgtc 786301 ggaacaaatg cgattggcac ggcgctccac atcagcgagc cggttgcaat acaaggatca 786361 gagcattact ctatcgcttc ccatctttgg aactgttcag ctgctccgat tcaccatgag 786421 gatggcagcc ttgcgggtgt aattgacata tcatgcccgg cggcaggcgc gcatcctcat 786481 atgcttggta ttgccacggc gattgcctat gccgctgaac gggaactcgc agctaaaagc 786541 cgtgagaaag agctggagct gatcagccgt tttggggaga gagctgcatc cagtgtgccg 786601 atggtgctct gtaataccaa gcagcacatc atcagtgcga gcatgccgat tcgaacctca 786661 atgccggatt ggcagggccg gcacctgtac gagttgaagg aacggggcta ttcaatcgaa 786721 aatgctgtca ccataggaga tggcggcact tgtttttatc tttcggaaca aaagaaaaag 786781 aaggcgtttc gattcaatgg agtgatcggg caaagcggcc gatcgcaagc gatgctgatg 786841 caccttgaac gagcagctgc gacggatgca tcggtctgtt tgtcgggtga aacgggtacg 786901 gggaaggagg tcgcggctcg cgcgcttcat gagaacagtg agagacggca cggtccgttt 786961 gttgctgtca attgcggagc gattccgtct gatttgattg aaagcgaact gttcggatat 787021 gcagagggcg cttttacggg agcgaaacga aatggctata aaggcgcctt tcaaaaagcg 787081 aatcaaggca cattattttt agatgaaatc ggagaaattt cccactcgat gcaggttgca 787141 cttttacggg tgcttcagga acgcaagata acgccaatcg gcgggacgaa agaaattccg 787201 gttgatatca gagttattgc cgccacacat tgtgatttac gcgagcttgc cgaaaacgga 787261 aaaatcagag aggacttgtt ttaccgtctt catgtctatc caattgaact ccctccatta 787321 cgcgatcgca ccgaggatat cccggatctc tttgagtact acaaacagaa gaatcattgg 787381 ccaggcgatc ttccttctga tttttgtaat gtgctgaagc aatggaagtg gccggggaat 787441 atccgcgagc tgtttaatgt gtttgaacgt ctttctatca gatttccgga cggccggctg 787501 agagatgaat cgcttcccgc tttactggaa gccgctggat tgccggccag ctctgcagaa 787561 aaaaagccgg ctgctgccgg cgtgcttact tttcgtgagc aaatccaaaa ggatatgatg 787621 atcaaagcgc ttgaatctgc aaaaggaaac gtctctcaag ccgcaaaaat cagcgggatc 787681 ccccgaagca ctttctacaa acgcctgaaa aaattcaact tgtccgctga atcataaagc 787741 atacttcctt caggaaatgg aaacgttatg tattgaagga gggtgttacg atgaatattc 787801 aaagggcgaa agaaattgta gaatctcccg acatgaagaa agtaacatat aacggcgttc 787861 ctatttacat tcagcacgta aatgaagaaa ctggaacagc aagaatttat ccgcttgacg 787921 aaccgcaaga ggagcatgaa gtgcagctga acagcttaaa agaggattaa acaaaaatgg 787981 cccgcttcat aagcaggcca ttttgttatc cgcgcggcgc aaataaaata acacagacac 788041 cgatgagaca aatgaatgcg ccgatccagt catacagatc aggtgttttc cggtcaacaa 788101 gccatcccca caggaccgca agcacgatga atactccgcc ataagcggcg tatacacggc 788161 cgaaagatgg gaaggactga aacgtcggaa gaatgccgta tacaatgagg atcagcgccc 788221 cggcgattcc gtagccagct ggctttgcct ctctcagcca tagccaaacc agatatccgc 788281 cgccaatttc agcaagccct gccgcgagaa ataaaagaat ggtaatcagc atcatgagca 788341 ctcctcaatt tgcatttatc tttcattata gaggaggaga gcttttaaag cttcggatga 788401 ttctcaaatt ccttcaaata cgcttttcgc tgaacctctg taaattggct gatccaattg 788461 ttttgagcct cttcattcaa atggggaagg atatagcgtt caaccgcttc gaaaaacagc 788521 ggattcgtga tgatgttcca ggtcgggatt cgaacgattt tgccgtctgt tttctcgatg 788581 ataatatcct caaaaaagat ccctttcaaa ctgtattgat ggcgtcccat ataaagccgc 788641 ttcacctcgg aaaacagcac gctgcgcttt ctcaagaaga tttcgccact aggtccggtc 788701 tttatggtga aaatgacatt tccacggctt gtgaacgcag gaaaagccat aaagaatgtg 788761 atcaatccat aaatcatcgc cagtaatccg ccgcccaaat aaagcagggc atatttagat 788821 tcaaacgtga gggcttcaga caccagccag actcccacaa taaaggcgcc ccctgtagcg 788881 aggaacagcc aagcccttag aaacatcatg ctttttactt caatcatgtg ctgcccctaa 788941 agcttcggat gattctcaaa ttccttcaaa tacgcactgc gttggatgtc tgtaaactgt 789001 ccgatccaat tgcttttcgc ctcttcattc agatgtggaa ggatatagcg ttcaaccgct 789061 tcgaaaaaca acggattcgg aatgatgttc caagtgggaa tgcgaatggt cttctgatcc 789121 acggtttgga tcaatatatc ttcttggaag attcctttta gactaaattt atggcggctc 789181 atctcaattt tcttgatatc agtaaacgta acagacactt tgtcagtgaa cacttctcca 789241 ttttttcctg tcttgatgcg gaaaatggta tttccccgcg gggtgaaagc cggaaagaag 789301 atgataaata aatataaaca aaacaaggtg aacagaaagc cagcaggaat ggctaatagg 789361 taatatttcg tttgaaacgt aatacccata taaaagagcc acaaacatgc taatcccata 789421 ccggcagatc cgacaaaagc ccatattctc aggaacattt tgcttttgac ttcaatgatt 789481 tcttggtttt tcaatgcttt tctccttttg ttaattcaat tcttatcatt ttgaaatgat 789541 ttgatttaca acatccttat gagcagggag gatagaaaat tcattctggg tgatgcctgt 789601 gacaagccaa gtatggtggg cccccggcag gacgaatgcc atgtcagcca cttcaggagt 789661 gttatctttt ccatatgcca gacgcataag tgtatccatt ttccctttcc gcaaagccag 789721 atcatttgca aatcgggtaa cgtcctcttg gtggtcatgt ttttcaagga actcttttag 789781 atatgaaggg ttgtctgaag cgccctccaa gagtttttca aattcatttg atgtcaatgt 789841 tacaatcgat tctcttttat cctctgtatc tattatatgt aaaaactcat ctgtcttagc 789901 aagtaaccct tcacttgatt ccatttttgt aatgcgatgg acttgttcat caaaaaggag 789961 ttcgtgagag taggtgccga attttgatac atggcatgac acattctgtt cggcaccttg 790021 cccgttaaat ttagaaagct tcactgtata gtcagcgtcg tttaatacat ggataaacgg 790081 acagtactcg tcctttaacc gatattgatg gttccgatat tccgctgcat ccttggctaa 790141 gagtgagcgg cacgcggctt caaataaggc gccgagctgt tcatcttcta tttccggaaa 790201 ataggcctgc ttcaaggcca ttccctgttc aaaaaaccct tcgctgtaaa agcaaaacaa 790261 gagttcttct atgctaattg taaactgctt cattgtttat tctcctatcc aaatgaaaat 790321 ttccctttaa ggaaatgggt tgcgccgtgt ataagcgaat ccgctgtttt ctttgctttt 790381 tccattcctt ttttcgcgct gtctatccct ttatgtatcg atttattcgc cgcatctatg 790441 ccgtcattca ctgatttgac gactttgccg gctgattcca gccctttttt ggctgtatca 790501 acaacagcat ggatcggttc tttcagcttt aaggctgctt tttcagcaaa accggctgta 790561 tatttggcga tttgttctcc gacgactccg ccaatgtatg aacctgctgc cccaagaagg 790621 acagtaccca caggtcctgc aaagcttccg attgcaccgc cgatgacagc accagctgtg 790681 gcaccgccgg caacaaaaat cgtattattc acagcattcc cgacggcctt ggcgttttca 790741 cgcttgagaa cttccggttt atcctggtat tttgcataat tttcagcaat tttcacgcct 790801 gctccgaatg tttcggtcgc tccggtaatc agtgtggcgg taatggcatt tcctttcgcg 790861 aatctcaagc ccgtttttcc cacatccttc aaagtggagc gtacgccggc ttcattaaga 790921 aatccttttg tgtagcttct gacgctgttt gaaaaatcca ccgtgtcctg aggaaagtat 790981 tttgtaaact ttttatgtac caaatctgaa aatggacggt ttgtcttttt caacaaatat 791041 ttaggattca aaagcactct tgccgctttt tgataacgtg agctgtcaac ggccctggaa 791101 atatccaaga gcagttttga gtgctgggct gtatgcaagc cgcttggttg tttcacaaat 791161 ttcgtaagcc ctaatccgta atattttccc tgcgtcagca taagagcggt taagcttgtc 791221 atcgtaccgt atttgtcgta ggcattgtag agctttcgca aaatatcatc ttgttccaca 791281 aatttatcgc ctgtttttct gatgaaaatc tcattgtcac tcagcttagt gacgagcgcc 791341 tttcctgagc tccacgcatc gcccactcca gaaaaacagc tgctgtagcg gggatcgcat 791401 tgcaaaatca tctgccccag ctccacatgc aggtccttat atttgttttc catatcagtt 791461 aattcagtga ctacatcatt tgcaagctgt tcgagcttat ccggatcaac tgcaatgttt 791521 cctgacacac cgttcacctc ccgagtttat gtctttcctc tcttgcttta cgctccagtt 791581 cttccattct ggcaatttca gcttttcgtt cttctatttt gacagcggca gccttcagct 791641 cttggcttgt ttcaagcagc tcctgttcga attgatcgta ggcggctttc gtttcctcga 791701 aatcctggtc aaacgaatct cttgctttgc cctgccaagc atctcccaat gcagataacc 791761 gggattcaag cagcattttg gagcttctga cctcttctgc ggccgcacta tacttgtttg 791821 ccagctcaat gactttatat gagtccaact tttgtcccct gccttttcta aattcacgca 791881 caattggatg ttttatataa atgattataa ataattcggc atgtatccga atcgtacaaa 791941 agaacctttt cataagaatt ggaagggcgt atattcactt aaaattcaca gttggtgaga 792001 ctttaagatt acaaaaaagg taaaaaaacc aaatctctca gacataaggc aaatgagaaa 792061 tttcccgctc tatgggaaaa aacactaaag ttgatcaaat gacctaagtg cgccaaacgt 792121 gttacgggac gagctatctc atggtataaa tggaattgta aacgttatca aggaggtcgt 792181 catatgaaga aaaaatcatt ctcaatcgta atagcgggcg gagggagcac tttcactcca 792241 gggatcgtac tcatgctctt ggaccatttg gaggagtttc cgatcagaaa gctgaagctg 792301 tatgataatg ataaggagag acaggatcga attgcaggcg cctgtgacgt ttttatcaga 792361 gaaaaagcgc cggatattga atttgcagcg acgactgacc cggaagaagc ttttacagat 792421 gtcgattttg ttatggcgca catcagagta gggaaatacg cgatgcgcgc gcttgatgag 792481 caaattccgt taaagtacgg agttgtcggc caggagacgt gcgggccggg cgggatcgca 792541 tacggtatgc gttcgatcgg cggtgtgctt gaaatattag attacatgga aaaatactcg 792601 cctgatgcgt ggatgctcaa ttattccaat ccggcggcaa ttgtggctga agctacgaga 792661 cgccttagac cgaattctaa aattctcaat atctgtgata tgccggttgg gatcgaagac 792721 cggatggcgc aaattcttgg cttatcctca agaaaagaaa tgaaggtccg ctattacgga 792781 ttgaatcatt tcggctggtg gacatcgatt caggatcaag agggcaacga tttaatgccg 792841 aagctgaagg aacatgtatc ccaatacggt tatattccga aaacagaggc tgaagctgtg 792901 gaggcaagct ggaatgacac gttcgccaaa gcgcgtgacg tgcaggctgc agatcctgac 792961 acactgccga atacgtattt gcaatattat ttgttcccag atgatatggt gaaaaaatca 793021 aatccgaatc atacgcgggc gaatgaagtc atggaagggc gcgaagcttt tattttcagc 793081 caatgtgaca tgatcacacg tgaacagtcc tcggaaaaca gcgaaattaa aatcgatgac 793141 cacgcatcgt atatcgttga tcttgcccgg gcgattgcct acaacacagg tgaaagaatg 793201 ctgttgattg ttgaaaataa cggtgcaatt gcgaactttg acccgactgc gatggttgag 793261 gtgccatgca tcgtcggctc aaatggacct gaaccgatta ccgttggcac cattccgcaa 793321 ttccagaaag ggctcatgga gcagcaggta tccgttgaga agctgactgt tgaagcgtgg 793381 gcagagaaat cgttccaaaa gctgtggcag gcgctgatcc tgtcaaaaac agtgccgaac 793441 gcgcgtgtgg caagactcat tcttgaggat ttagtggagg ccaacaaaga cttctggcct 793501 gagcttgatc aaagcccaac ccgcatatca taaatgaaat tcccccattt tcgaatctgt 793561 aattgtatat aatagaaaga aaatgggggg atctgatatg cagctcgaag aactgatcaa 793621 tcagcactac agcaaattga atgacaacga ttttcatatt ttaaaatata tattgaatca 793681 taagcacaca tgctatcacc ttggaatcga cgcgctggcc aaagcttgca gtgtatcgcg 793741 ttcctcaatt ttacggcttg cccaaaagct cggtttcagc ggttacagtg aatttcgcgt 793801 ctttttaaag tgggaagatc agccggaaga aggcgagagt atgagttttg aaaagctgct 793861 tgatgatatt gaagcaaatt tgaagttttt acggacaaag gacatgacgg acatgtgcca 793921 gctgattgat gcagctgacc gcattttcgt ctacggttct ggaaatgcgc aaaagatatg 793981 cgcccgcgac ctgcaaagaa tgtttattcc gcgccatcgc tatcttattt tgattgaaga 794041 cacaaatgaa tttaatttga tgcgcgatga ttttaaagtg aacgatctgt ttatcatcat 794101 ttctctttcc ggagaaacac cggagctgat tcctcaggca agaatgcttt ctgcaaaggg 794161 tattcccttt atttccatta cgaatttaaa aaacaatgtc ctcgcccagc tgactccgca 794221 taatctttat gcgacaagca aacctgtgac attaagcgat agaacggaaa ttgtcgcttt 794281 tgcaccgttt tttctcgttg gcgaagcatt gttccgcgca tatgttgatt acaaagaggc 794341 agaaaaaaat gacaatgagt agcagggggt tctggtatga tgcaaaaaat tcagcgcttt 794401 ggaagcgcga tgtttgtgcc tgttttatta ttcgcgttcg ccggcattat cgtcggtatc 794461 agcacgctct ttaaaaataa aaccctcatg ggaccgctcg ccgatcctga cggtttttgg 794521 tatcagtgct ggtatatcat tgagcagggc ggctggactg tttttaacca aatgccgctc 794581 ttattcgcca ttggcatccc ggttgctttg gcgaagaaag ctcaggcacg cgcctgtttg 794641 gaagcgctta ctgtctacct gacattcaac tattttgtca gcgcgatatt gacggtatgg 794701 ggaggagcat ttggcgtcga catgaatcaa gaggtcggcg gaacgagcgg gttaacgatg 794761 attgcgggca taaaaacgct cgataccaac atcatcggag ccatctttat ttcttcgatt 794821 gtcgtctttt tgcataatcg ctattttgat aaaaaactgc ccgattttct cggcatcttt 794881 caaggctcaa catatatcgt gatgatttcc ttctttatta tgatcccaat tgcgttggct 794941 gtgtcttata tttggccgat ggttcaatcg ggaatcggct cgcttcaaag cttcctggtt 795001 gcttctgggg cggtgggcgt ttggatatac acgtttttgg aacggatttt aattccgacc 795061 ggccttcatc actttattta cacgccgttt atttatggcc cggctgtagc ggaaggcggg 795121 atcgtcacgt attgggcaca gcatctcggc gaatattcgc aaagcgccaa accgctgaag 795181 gagctctttc cgcaaggcgg attcgcgctt cacggcaact cgaaaatctt cggtattccg 795241 ggtatcgccc tggcttttta tgtgacagcc aaaaaggaaa agaaaaaact cgtcgcaggg 795301 ctgctgattc ctgtcacact gacagcgatt gtcgccggta ttacagagcc gattgagttt 795361 acgttcttat tcatttcacc tttcttattt gcggttcacg ccgtgcttgc cgccacaatg 795421 tcgacagtta tgtatatggc cggcgtcgtc ggaaatatgg gaggcggact gattgaggcg 795481 gtaaccttga actggattcc gctctttggc agccacggta tgacatatgt gtatcaaatt 795541 ttgatcgggc tctcgtttac agcaatttat tttttcgtct tcagattttt aatcctcaaa 795601 ttcaatatcg ctacaccagg acgggaaaag gatgaacagc aggaaacaaa gctatattcg 795661 aaaaaggaat acagagaacg aaaaaacaag gatgaaacgg cctccgctgc tgaaacggct 795721 gatgacaccg cttttctgta tattgaagcg ctgggcggaa aagacaacat cactgaagtc 795781 acaaactgcg ccacccgcct cagagtcagt gtcaaggatg aaacaaaggt tgaacccgac 795841 agcgtattcc gcgcgcttgg cgcacacggc gttgtcagga acgggaaggc gtttcaggta 795901 attatcggat taagcgtgcc gcagatgcgg gagcgtgtgg aaaaaatatt gaatcaataa 795961 agactgccct ccttttcggg agggttttcg tttgccgtca aaaagaccgc catagtaaag 796021 taaagaaaga gacaatcgag taaaaagggg tttggaggct tttacatgca aaaggctttg 796081 tcgtttttaa aaccatattc attgctggcg ggaattgctc tgattcttat gctgacggag 796141 cttgcagttg aactgatgca gcctttattg attgcaaaaa tcatcgacga tgggatattg 796201 aagcaagatc tgcggcatgt atggatatgg ggcacggtca tgatcgggct gaccgtgtta 796261 tcctttgcgg cggggatgct gaattccttt tatgccgccc atgtcagcca aagcttttcc 796321 tatgatacga gaaaagggct ttttcaaaaa atccagtcct tctcctattc cacatttgga 796381 cagttttcgt cctcttctta tattacaagg ctgacaaacg acgtcacaca ggttcaaaat 796441 atgattttta tgagtttgcg gtttatgctg cgggctccct taatgattgc aggcggcatt 796501 gtgctgtcgc ttgccgttaa tgtgaaactc gggttttttc tgcttgtgac cattccgatc 796561 ctgatcttgt ttttgctatg ggtattaagg aaaggcgggg cactgttccg ctcagtgcag 796621 aaaaggctgg atcaagtgaa caccatcatg caggaaaatt taattgcaat caagctgatc 796681 aaagcgctgc ttcgcggcag ccacgaagtc aaacgattta tcaaagccaa cacaaggctg 796741 atggaaaaaa cggtttcggc ctttcagctt gtggaattca cgatgcctgt actgatgctg 796801 ctgatgaatc tctgcatcct tttgattttg tgggcggggt cctacagtat tacgagcgga 796861 agcactcagg ttggcgatgt tgttgcgata attaactacg caacacgaat tacaggcgcg 796921 ctttcgatgt ttccgttttt gattatgatt ttcacccggg cgaaggcttc aggggataga 796981 atcggtgagg tgcttgaaac agaaggcgac gagcgggagg aaggcaccat atctgatcgt 797041 ttgtcaggac ggattgagtt tcagcatgta tcctttcgct atcctgaaat ggacagagaa 797101 gcgctcagga atgtctcatt ttccgcaaag ccaagagaaa cgatcgcgat tctcggtgcg 797161 acgggctcgg gcaagtccac gctttttcag ctcattccgc ggctttatca gccggattca 797221 ggccgcattt acatagatga aaagccggtt caagatattc cggctgaagg gctgcgcagg 797281 caaattggat atgtaccgca ggaagtcctc ttgttttccg gcacaatcaa agaaaacatc 797341 gcttggggca aagaaaatgc ttcactagat gaaataatgg atgcggcaaa acttgcgcaa 797401 attcatgaaa cgattttaaa gctcccaaat ggatatgaca ctgttttggg gcaaagaggc 797461 gtcaacctgt ccggcggcca aaagcagcgg atttccattg cgcgggcgct gattcgaaaa 797521 ccggctatcc ttctattaga tgacagcaca agcgcgcttg atctgcaaac ggaggcgaag 797581 ctgcttgaag caatcagcac ataccattgc acaactttga tcattacaca aaaaataacc 797641 acggcgatga aagctgatca gattttgctg cttgaggacg gcgaactgat tgaaaaaggc 797701 actcacagtg agctgctttc tgaatctcag ttatacaagc gcatttacga gtcacaattc 797761 ggaagggagg ggagcgagtc atgctaaaag acatccgcaa gcctttccaa tatcccaaac 797821 tgccaattga caaaaaagaa ggcgcgaaaa agcgggcgaa agcaaaggat acaaagggca 797881 cactgagacg aatctggtct tacttggctg aaagaaaagg actgctcata cttgtcatgc 797941 taatggttgt catcagcgcc atattcggac tccttggtcc ctttgtgatc ggaaaggcca 798001 tcgaccattt tatcgtcggg aaaacggtca gcggcttgat tcctgttttg cttcttctgc 798061 tcgctatcta tatcattcag tccctgtcgc tttggtttca aaactattgg atgattacga 798121 tctcgcaggg cacggttttc agaatgagaa gcgaattgtt cacccatctg catgagctgc 798181 cgattccatt ttttgataaa cagcggcacg gcgagctgat gagccgggtg acgaatgaca 798241 tcgaaaatgt cagttctacc ttaaacacgt cagtcattca aattttgtca agtgtgatca 798301 cctttgtcgg gacgattgcg gtgatgctgt acatgagccc gctccttact ttgattacgc 798361 tgaccattat tccggtgatg gcagcgagcc tgaaatggat caccaaccga acgggaaagc 798421 tgtttaaaga acagcagaaa aaccttggtg atctgaatgg gtatattgag gaatctgttt 798481 caggcgcaaa ggtcatcaaa gcatattcac gtgagaagca gattactgct gaattcctcg 798541 aaaaaaacgc tgcactcaag acgtcgggct tttgggcgca gacgatttcc gggtttattc 798601 cgaaggtcat gaactctttg aataacttaa gctttacaat gattgcggca atcggcggtt 798661 tgtttgcgct gaaaggctgg atctcgatcg gctccatcgt tgtctttgcc gagtattcaa 798721 gacaatttac acgcccttta aacgatctgg ccaaccagtt taatacgatg ctgtccgcaa 798781 tcgccggcgc tgaacgggtg tttgacgtgc ttgatgaaaa agaagagcgc gaggatgaaa 798841 agaacgccgt gcatcagccc atccaaacag gcagcattga attccgggat gtgtccttcg 798901 gttacgataa agggcagcag acactgaagc atttacagtt taccgtgcct gcggggcagt 798961 ccatcgcgtt tgtaggaccg acgggggcgg ggaagacaac cgtcactaac cttctcgccc 799021 gtttttacga gcctaacgat ggaaaaattt taatcgatgg tacagatatt aaaaccctta 799081 ctagagcaag cctaagaaaa aacatggggt ttgttcttca ggattctttc ttatttcagg 799141 gaacgatcag agaaaacatt cgctacggca ggcttgatgc ttctgatcag gaagtcgaag 799201 ccgctgcaaa aacagcgaat gcccatagtt ttattgaaag gctgccaaaa gggtatgaca 799261 ccgtactgac gcaaaacggt tcgggcatca gtcaagggca gaagcagttg atttctatag 799321 cgagggcggt gcttgccgat ccggttcttc tcattttgga tgaagcgaca agcaacattg 799381 ataccgttac agaagtcaac attcaagaag cgctcgcccg tttaatggaa ggaagaacaa 799441 gcgtcatcat tgcccacagg ctgaacacca ttcaaagagc ggaccagatt gtggtgctaa 799501 aaaacggtga aatgattgaa aaaggcagcc atgacgagct gattcggcaa aaaggatttt 799561 acagtgactt atatgaaagc caatttgaga aatagacctt tgtcctgcac agaggtcttt 799621 ttttgttaca gttttatagt acttttattt cattttcgta aaatgtaaca aaattacttg 799681 acgtaaacaa gttatgtata tatactagct tacattaagt aagtgataac atttatcaag 799741 gaggataaaa tgaataaatc atttgaaatt ggcacattac ttttaagagt tattacaggt 799801 attatctttt ttgttcacgg tttatcaaag tttcagggaa tggagggcac catccaattt 799861 ttcggcagca taggccttcc aagctttatg gcgtatgtca tcgcagcgat tgaactgatt 799921 ggcggagtgc ttgtcttctt cggattggct acacgtattg tcggtgtact gttcgctctt 799981 acactgatcg gcgccatcat cactgttaag ctgaaagcgc cattcatggg caatgcagaa 800041 tttgattacc ttctgctttt gacatccatt cacctggcgc ttactggaag tcgattcctg 800101 gcgctggacc catttgtgtt taaaggaaaa aagaacggaa acgtttcagc ataagaaaag 800161 aggcatgcag catgaccagc attcatgagg atacacacat tggctatgcc aaactcacaa 800221 ttcgcagtct ggagcgttcg cttcagttct actgtaacgt catcggtttt caagtcttaa 800281 aaaagacgga ccgccaagcg gaattaacgg ctgacgggaa acgcgtactg cttattcttg 800341 aagaaaatcc gagcgctgtc gtcttgcctg aacggtctgt gacaggcctt tatcactttg 800401 cgattcttct tccggacagg aaagaacttg ggatcgcgct cgcccgcctg attgaacacg 800461 gcattgctat cggacatgga gaccatgctg tcagcgaagc gctctacctg tctgatcctg 800521 acggaaacgg cattgaaatg tacgctgacc gcccccgcag cacgtggcag cgtgatcggg 800581 aaggaaacta cgtcatgacg acaaccgctg ttgacattga gggccttctg gaagaggcag 800641 gagatgagcg gaaaacatcg cttccgaacg atacaatcat cggacacatt catctgcatg 800701 tcagtgattt gaaagaagca aaggcgtttt atacagatgt actgggcttt gacattgtcg 800761 gaaactatgc gggcatgtcc gccctcttcg tttcagccgg ggggtaccac catcatatcg 800821 gcttaaacat ttgggcggga agaaatgcgc cgcctaaacc gacaaatgcc agcggactag 800881 attattatac tgttgtcctg ccccaccaag aggagctgga tttggtggca aaccgagtca 800941 aacatgccgg gtattcgatt gaagagacgg aaaacagctt tcgtgtgaaa gaccctgttt 801001 ccggcgccta tattacattt gtgatttaac tgcaatcccc ttgccgaaat aacggcaggg 801061 ggatttttta tttttgtccg ccttgttatg atgagagaac caacttgtta ggaggcgttt 801121 acatggaact caaccacctt gtgacgggca aaatagcatt aaatcaatat gtgcatcgct 801181 tagagcaaaa ggatgtttca ttttacgtcc actactgggg agcgatgacg aaccactata 801241 acacactgct tcataagcat tccttttatg aaatttgtta cgtggtaaga ggtgaaggat 801301 attaccttga aggcgatcgt acatatccgc ttcgtgaaca gacgattttt ttgtcaaagc 801361 cggagcattt gcaccaaatc aaaagtgaaa cagggctgtt ccttttttac gtcgctttcg 801421 agctgagcga ggatcagtca agcgccgaat ggatcaaagt gatggaagaa gtgaaacaaa 801481 gcccctttat cacaatgcaa ttgaaagatg gcgaaccgcc gggcctgctt tggaaaacgt 801541 taatgctgca agcagcgcaa cctgtcaatg cttttgacaa agagatccta tctcatttgt 801601 cgcatgcatt gatcctgtca ttaatccaaa cctttctccc gtacgcccaa cgcccgaaac 801661 aaaagcagcc cattcacaca tcttctgctt tgctgacaga ggtgaaactg cacataaaag 801721 acaatctgtc acagccgtta aagctgacgg atgtcgctag ccactttcat atctcaggga 801781 ggcatttatc acgtttattt gcagcagaac tgggcgtcag ctactcagaa tttgtccaaa 801841 atgaaaaaat aaacaaagct gccgaactgc tgaaatcaac gaatttgtcg attaaagaaa 801901 tagcggaaga aatcggtttc tcagtacatt atttcactcg cgtcttttcc gctaaaatcg 801961 gcagctctcc agggcttttc cgctcccttt ataaagactc aaaaatgacc gcatttcaaa 802021 tcaataaacc ttttcaaaaa atcgaacagg ccaagccgca cgaataagat gtcctgaaat 802081 gacaaaacaa tgtcttcata tgataaagac gcgagaaatc tcgttgtctt ataatctttt 802141 tagaaagcgg ttacaacaag gggtattgct gaaggaggga tgcattggct tatgcttggt 802201 gtcgggtgct ctgccattct tgaaagaagg ggaagaaagc cgtgagtaca aaaaagaaag 802261 aggctgtaat aggaaaagaa agcttagctc ataaagggct tttacgaacg attacattgg 802321 tatctacatt cggcggcctg ttgttcggtt atgatacggg tgtcattaat ggggcacttc 802381 cttttatggc aactgcaggt cagctgaatc ttacacctgt tacagaagga ctggttgcga 802441 gttccctgct tctcggggca gccttcgggg cgatgtttgg aggacgtctg tccgatcggc 802501 acggccgccg aaaaacgatc ctttatttag ccttactctt catcgcagcc acacttggct 802561 gtaccttttc accaaacgcg tccgtgatga ttgcctttcg ttttctgctt ggactggcgg 802621 ttggctgcgc ttctgtaacg gttccaacct ttttagcgga aatttcgccg gcagaacgca 802681 ggggacgaat cgtgacacaa aatgaactga tgatcgtaat tggccagctt ctggcataca 802741 cctttaacgc cattattggc agcacaatgg gggagagcgc aaatgtatgg cggtatatgc 802801 tggtcatcgc gacacttccg gctgttgtgt tatggttcgg aatgctcatc gtgcctgaaa 802861 gcccgcgctg gctggcagct aaaggcagaa tgggtgacgc cctgcgggtg cttcggcaaa 802921 tccgtgaaga cagtcaggca cagcaggaaa taaaagaaat caaacatgcg attgagggca 802981 cagcaaaaaa ggccggcttt catgattttc aagagccgtg gataaggcgc attctattca 803041 ttgggattgg aatcgccatc gtacagcaaa ttaccggtgt caattcgatt atgtactatg 803101 ggacagaaat tctgagagaa gccggttttc aaacagaagc tgcattaatc ggcaatattg 803161 caaacggtgt tatttcagtt attgcggtca tttttgggat atggcttctc ggcaaagtcc 803221 gtcgccggcc catgctgatc atcggacaga ttggcacgat gacagccctt ctgctgatcg 803281 ggattttatc cattgtcctt gaaggaacac ccgccctgcc gtatgttgtg ctgagtttga 803341 ccattttgtt tcttgcgttt cagcagactg ccatttctac ggtgacgtgg ctgatgctct 803401 cggaaatctt tcctatgcat gtgcgggggc ttggcatggg gatcagcacc ttctgcttgt 803461 ggacagctaa ctttctcatt ggattcacct ttcccatttt gctcaatcat attgggatgt 803521 cggcgacatt ttttatcttt gtcgctatga atatcctagc gattctattt gtgaaaaaat 803581 atgtgcctga gacaaaaggg cggtcacttg aacagcttga gcattccttt cgccagtatg 803641 gccgccgcgc tgatcaggaa atccaaaatc aaacaactca cttatcgtaa cctgagatac 803701 caggaggaat ctatcaatga aactatctta tgtaacagac agcctagggc atttgccttt 803761 tgaagacatg ctcaattttg ccgcaaagct tgggatcgat acacttgaaa tgacaaccgg 803821 gggctggtcg ccggcacctc acttgaatct tgatgaattg ctgcaaagca gcgaaaaaag 803881 aaaagaattt tcacaagcgc tggaaaagcg gaacatgaca ctttgcgcat taaactgctc 803941 ggggaaccct ttagatccgg gtgaattggg caaatcgcac agagacataa ctgacaaaac 804001 gatggagctg gctggattat taggcgtcaa aaaagtgatc atgatgagcg gtttgccagc 804061 cggcggcccg gacgacaaag tgccgaactg gatcacatac acagtaagct ggcctcccgt 804121 tttaaaagat atcctcaact atcaatggga agacgttgcg atcccatatt ggaagaagct 804181 tgtcaaaaaa gcggaggcct gcggcgtggg gaaaatagcg cttgagaact tcagctctca 804241 attagtctat aatcctgaga ctctctttcg gctcagaaat gcagtcggcc cgatggtcgg 804301 tttgaatctt gacccgagcc atttgttatg gatgggcgca gacccgatca tcgcagcaag 804361 ggagctcggc tcagccattc accatgtcca tgggaaagat gtcagaattg aaagatattt 804421 atcggcggtc aacggacttt tagaaacaaa agaagtgaca gatcctgcaa accgggcgtg 804481 gaattacgta gctgtcggct gtggacagga tttacagtgg tggaaggaat ttttttcagt 804541 tgtaaaaatg atgggatatg aaggtgaggt ttctttagaa atggaggatc tgacgatgtc 804601 acctgaagcg ggcatccgta cttctgtaga agctttaaaa caaaccatca gccaatagga 804661 ggttttcatg atgctaaatg gagaaagaat catctctaag ccgcttcgct gggcaatggt 804721 aggcggcggg cggctcagcc aggttggata taaacatcgt attggagcgc tgagagacaa 804781 tactgctttt caattaactg ctggcgcttt tgatatcgat gccgaaagag gaaaagattt 804841 cggggtgaac cttggagtgg atgcggaacg ctgttatccc aactatcaaa ccatgtttgc 804901 cgaggaagcg aaaagacagg atggcataga ggtagtatcg attgccactc cgaacggcac 804961 tcattatgag atttgtaagg cggcgcttga agcaggagtg catgtcatct gtgaaaaacc 805021 gctgttcttc acttcagcag aggggcagga aatcaaagcg ctcgcagaga aaaaagggaa 805081 aattgtcggc gtgacgtacg gtttttcagg caatcaaatg cttcttcaaa tgcgtgcgat 805141 gattgaacaa ggaatgatcg gcgatattcg cgtggttgac ttgcagtaca cacacggttt 805201 ttgtgcaaca gatgaaggtg aaaagataag cgctgcacag aaatggcgtg tcgaccctgc 805261 gatcgccggg ccaagctttg tgctgggcga tttatctacc cacacgtatt atatgtcaca 805321 gcttattatg ccaaagatga aaattaagga gctgctgtgt gaccgacaga gcttcgtcgg 805381 cagccgcgca ccgctagagg ataatgccca tgtgctgatg cattatgaaa atggagcggt 805441 cggaacgatg tggacatcgt caatcaatgc cggatgtatg gatggccata gaatccggat 805501 tgtcggctca aaggcaagca ttgagtggtg ggacagcaag ccaaatgaac tgacgtatga 805561 agtgcaggga gagccgggcc agacactcgt tcgcggcatg ccgtatttag atgatgtttg 805621 caacgccgat gaacgactgg gcgccttaca cagcgaaggg ctgtccgaag catgggccaa 805681 tatttatctt aaatttgcca ttgcgataga cgccaaaaac cgtgaagatg aagaaatctt 805741 gaacaacttg gtttatcctg acattgatgc agggatcgag ggcattcgct ggattgagaa 805801 ctgcgtgcgc tcggcaaacc aagggtcagt ttgggttgaa tttaaataaa tgagggaatg 805861 cgccgcatat gacataaagt tcatatgcgg tttttatttt ccagaaactc ctgtcaaaaa 805921 tgccctgagg caggtatgat aagaagggaa ttgggtatcg ggagtgatga gcgtgaaagc 805981 tctttttttt acgagaatgt tcaccttgat ggtgagctgt ttaatgtatc tgtccattgt 806041 gaaagaggat aactggtttg gatatgtatt tatagcagca ggtgctgcca tgtatgcagc 806101 caatcatgtt ttgctgacaa aagagacaaa tgccatctgg ttctgcctga ttgatattgc 806161 aatcggcttt tcgttcggat ttatctttcc cggcacaggt ttgttcatta ttatgctttg 806221 tccggttgcg gtcgcctttt ttctgcgggg gtttcctaaa agaacagcat ggtctgtctt 806281 atgtctttcc tctattttat ttttgaccgt cctcatccgt acatatgcga tgttcggcaa 806341 tgaatttgtc attgatcatt tgactagcat gacattcgtt gtcttctgcg gtgtcgtggg 806401 caaattaatc cgcaagctgt tggatgcgca ggatacggca aaacagcagt ttcaggaact 806461 gacggagtcc catctggcgc tgtctgctgc acatcaggag ctccatttat atgcgaagca 806521 ggttgaagag ctgactgcca tttacgagcg gaacagaatg gcgcgtgaaa tccatgatac 806581 agtggggcat aaaatgacgg cccttctcgt ccagctgcag cttttgcgtg aatggcaaaa 806641 aagagacagc caaaaagcgg atgagacagt aggtgtctgt gaaacacttg cccgtgaagc 806701 gcttgatgat gtccgcttat cagtacgcac tctgcaaact gaaaacgatc cttcgctaat 806761 cgaatcgctg aaacagctga cagaggactt ttgcaaaaat gcaggagtca caacagaatt 806821 tgcggtcagc ggtgatcctg caatcatccc gctgtctctc catccgaccc tgatcagaac 806881 ggtgcaggaa gcactgacca atgccaaacg gcacggcggc gccgcagcct gttcgataca 806941 gcttgcctgc acaacggaca gcatcagcct tgtcattaag gatgacggca aaggcaatcc 807001 tgaggcagca cttggttttg gtctcttgaa tatgaaaaag cgggcagcgg agcatggcgg 807061 aatgatccgc tttgaaagcg aacgggatca aggatttact gtaaatgcag aattttcact 807121 tgccaataaa aaatggagct tcgggcccgt gcagcaaaag gagagtttat catgattaag 807181 atcatcatta ccgacgatca ggatatcgtc agagaagggc tggcatccct gctccagctc 807241 cgagaagagc tcgatgtgat cgcaacggcg cgaaacggac aggaagcctt cgaaaaggcg 807301 aaagagctgg agccggatat cgtgttaatg gacatccgca tgccggtttc caacggggtg 807361 gagggaacaa aattaatcac aagctcgctg ccaagcgtaa aggttttgat gctgacaacc 807421 tttaaggatt cagcgctgat tgctgaagcg cttgaagagg gagcaagcgg gtatctgctg 807481 aaggatatgt ctgcagatac gattgtaaaa gcagtgatga ctgttcattc tggcggaatg 807541 gtgcttccgc cggaattgac tgcccaaatg ctgaatgaat ggaagcgtga aaaacagctg 807601 aaaggaataa atgagataga aaaacctaac gagctgctcg acctgaccga gcgcgaaatc 807661 gaagttctgg ctgagctggg atacgggctg aataacaaag aaattgccga aaagctttac 807721 attacagaag gcacagtcaa aaaccacgtt tcaaatatta tcagcaagct ggctgtcagg 807781 gacagaaccc aagccgccat ttactcggtc agatatggtg tatctgtctt ttgacatatg 807841 acgttttgca tatacgcttc tctgaaaagg ccttttacag gccttttttt catgccctat 807901 gttctatctg ccgctacatg ccgcacgcct ttctttcttc tacaatggca atggatcaaa 807961 aaaaggagtg agacgacgtg ctgcaagcag aaaacatcaa aaaggcatac ggaaaaaaaa 808021 caatcgtgaa aggcatttct ttttccctca aaaaggggga gtcgttcggt ctgctcgggc 808081 ctaacggtgc ggggaaatcc acaaccatct cgatgatttc cggccttgtg ccgcatgaca 808141 gcgggaacat cacggtgggc ggctatgtta tcggaaaaga aacggccaaa gcgaaacaaa 808201 aaatcggcat tgttccgcag gaaattgcat tatatccgac gctgacggct catgagaatc 808261 ttatgttttg ggggaaaatg tacggactta cgcacggtga ggccaaaaaa agagcggctg 808321 aggtccttga atatgtcggt ctgactgagc gggctaaaga taagattgaa acattttccg 808381 gggggatgaa acgaagaatc aacatcggtg cggctttaat gcataagccc gagctgctga 808441 ttatggatga accgactgtc ggtattgacc ctcaatcgag aaatcacatt ttagaaacgg 808501 tcaaacagct caacgaaacg ggcatgacgg tgatctatac gagtcattac atggaagaag 808561 ttgagttttt atgcgaccgg atcgggataa ttgatcaggg ggaaatgatt gcgattggca 808621 caaaaactga tttgtgcagc cgccttgggg gcgataccat cattcagctc acggtcagcg 808681 ggatcaatga agcgtttctt gtggcgatcc gatctctggc ccatgtgaat gatgtaacag 808741 tacatgaatt agagctcaaa attgacattt ctgcggctca tcatgagaaa gtcgtcacaa 808801 gcctgcttgc tgaagccact gctcatcata taaacctgct gtctcttcag gtgcaggaac 808861 cgaatctgga gcgcctgttt ctgaatctga ccggccgcac gttgcgggat tgaggaggga 808921 cggcaatgaa aaaaagcata tggatcgcat ggaaagatgt gaaaatcaga atcacggaca 808981 gaaaagggtt tatgatgctt atcctaatgc cgctcatcct aacctgtatt ttaggcgcag 809041 cgctcggatc agttgttgac ggaggcagcc ggattgatga tatcaaagtc ggctacattc 809101 aatcagacca gtcagataca gcaaacatgt ttacaaaaga tgttctcaaa aaaatgaagt 809161 cgataaaggt cacaaaagtc ggcagcaaag acaagatgaa aaaactgatt gatgaaaaga 809221 aaatcgatgt aggcatcgtt atcccgaacc attgggaagc cggcaaaacc tcagctgttg 809281 ttaatgccgc tcctgatcaa acattgaaaa gttccatcat tgaaacagct gcaagctcat 809341 ttatagagca atataaagcg gtaaaggaag ccgcgtcagg ctcaatggac tacatcagta 809401 aaacggaagc tgtaaagcaa ggaaaacttg accctgcaca gtttgcagaa aagctggcaa 809461 agacgctaga aaaagaaaca ggtgacaagc ttactattgc ggaaaaatct gtcggcagca 809521 aagccgttac cagttttcaa tactattcgg cggcaatgct ttgcatgttt atgctgtttc 809581 atatcacagt cggggcgaaa tcatttttac aggaaaagga tacggagacg cttgccagaa 809641 tgctgatgac gcctgcgcaa aaatccgtca ttctcttcgg aaaatggctt gggacgtatc 809701 tgtttgccat catacaattt ttcatatttc tgatcgtcac aatcaacgta tttggtgtgg 809761 actggggcgg taatctgctg ttagtgagtg tactcgggct ttcttacgcc gcagctgtat 809821 ctggtatttc aatgctgctt gcgtcgtgca tcagcgatat gaaaactgca gatgcgatag 809881 gcggcttcgg cattcaattg cttgcggttc tcggcgggtc catgctgccg ctgtaccaat 809941 ttccggacgt cttgcagtct gtatccaaag cggtgccaaa tcgctgggcg cttgacggct 810001 ttctttcttt aatggaaggg ggaggctggg ctgaccttca aaagcctgtg cttctttttg 810061 cggcgatcgg cttttgttca cttgtaattg gtatcagacg gcttcataca agataaggag 810121 gtacaaaagg tgaaaaaaat tctagccatt tgcggcattg agctttctct catttttaag 810181 aagccacaga actatttgat catgtttgct gccccgcttt tgcttacctt tgtatttggg 810241 agtatgctca gcggcaatga tgataaggtg cggcttgcaa tcgttgatca ggacgatacg 810301 attctctcac agcattatat tcggcagctg aaggcacacg atgatatgta tgtattcgaa 810361 aacatgtctg aaagcaaagc gtcagaaaag ctgaaacaaa agaaaattgc cgggatcatc 810421 gtcatttccc gctcgttcca gacacagctg gaaaaaggca aacatcctga gctgattttc 810481 cgtcacggcc ctgagctgtc ggaagcgccg atggtcaaac aatatgcaga aagcgcattg 810541 gcaacgctca atattcaggt gaccgcggca aaaacggcat ctcagacagc gggagagaac 810601 tggaaggcgg cgtataaaac ggttttcgcc aaaaaacatg aagatatagt tccggctgta 810661 acacgacaga cgctcagtga taaaaaagag ggtgcggaag caagtgacac agcctccaga 810721 gcagcagggt tttccatcct gtttgtcatg ctgaccatga tgggagcggc tggaaccatt 810781 ttagaagcaa gaaaaaacgg cgtatggtcc agattgctta cagcctctgt cagccgagcc 810841 gaaatcggtg ctgggtatgt gctgtccttc tttgtcattg gctggattca atttggaata 810901 ttgcttcttt ccacccattg gctgtttggc atcaactggg ggaatccggc tgcagttatt 810961 gtattagtgt cactttttct attgaccgtt gtcggcattg gattgatgat tgcggccaac 811021 gtcagaacgc cagaacagca gcttgcgttc ggcaacttgt ttgtcatcgc aacatgtatg 811081 gtgagcggga tgtattggcc gatcgacatt gaaccgaaat ttatgcaatc catcgctgaa 811141 tttcttccgc aaaagtgggc gatgagcggg ttgacagaga ttatcgctaa cggtgcccgc 811201 gtcacagata ttctcggaat ctgcggcatt ttgcttgcat ttgctgcgat cactttcgca 811261 gcggggctga aagcgctccg agcctaaaaa acatctgccg tttaggcaga tgtttttttg 811321 catgtgggta cattcgtatg ggtgcagcct gaactgcggt taatccttat ctatcatagc 811381 taaaattgat tccagccaag aaacgtaatt tttctcccgc tccagcgctt tcgttagcac 811441 aagatagtgg ccgaagtccg gtgaagaaaa tgacatcggc tctgctgaag ccataagctt 811501 ttcatagctt ccctgtaagt cagaaagctt ggcctggcgt ttttgcagct ggtctttgaa 811561 caaatcagaa gcctcctggc gcgatagaca agaaatgaaa taagccttca gcataaattc 811621 atccttcacc gtctcgggta tcggctggtg gcggatcagc cagtcatgca gctcctgctt 811681 tccgctgtct gtcagggtgt acatcttttt ctccagcttt gtgccctgaa tcgttgtccg 811741 gaacgtgata aatccttcat ccgtcagctt tttgagctca gggtaaatct ggctgtgctt 811801 ggcgctccaa aactggccga gctcctcttt aaaataactc gtaatatcgt atccactcaa 811861 ttcgcctttt cgcaaaagcc ctaatatggc gtattttaat actctcatgc tatcctccgt 811921 gtctggctgt ttcgcaaaac agatgagccg gtgctcaact gtgattctaa ctgcctattc 811981 cccttattat agaaaaggga ggaagggaac acaaccgggc tctttggaaa tgaagataaa 812041 aggtttgtca gaaggtatcc gatttatctc cgtcaatata aaagagattt aaatttaatt 812101 ttcagaaaaa atagtaacga tattgatttt ttatatataa taggaaattg gtggtatgaa 812161 aattttttgg gggaataaac gtgaaaaaag tacttatggc attcattatt tgtttatcgc 812221 tgattctatc tgttttagcc gctccgccgt ctggcgcaaa agctgagtca gtacataatc 812281 ctgtcgttct tgttcatgga ataagtggtg catcatacaa ctttttcgct attaaaaact 812341 acttaatttc tcaaggctgg caaagcaaca aactgtacgc aattgatttt tatgataaaa 812401 caggaaacaa cctaaataac ggcccgcagc ttgcttcata tgttgaccgt gttttaaaag 812461 agactggggc aaaaaaagta gatattgtgg ctcatagtat gggaggcgcc aatacgctgt 812521 actatattaa atatttaggc gggggcaata agattcaaaa tgtcgtaacg cttggagggg 812581 ctaatggttt agtgtcatca accgcgctgc cgggcacaga ccctaatcaa aagatcctct 812641 atacatctat ttacagtctc aatgatcaaa ttgtcatcaa tagcttgtct cggttacaag 812701 gagcgcgaaa catccagctt tatggcatcg gtcatattgg cttgctttct aatagccaag 812761 tgaacggcta tatcaaagaa gggctgaatg gcggaggcct caatacaaat taatatcttc 812821 aaaaaacaac ctgctgtctc cgttacagtg ggttttttcg tctgagaaag ccatagggtc 812881 ttatgacctt agtctatcat gcatacgtca atttatgaca tcaggcactt tttcaaatag 812941 agcggacatg ttaaggtaca accatcgatt tctatcaatt tgaaataaaa ggagcgctgt 813001 tatgcaaatt aaagaaattt ttatgatccg ctgcatttcg tgcttaagtg tcgtcttgct 813061 ccatatcatt tcaatggtcc tgatgcttca ggcagaagct cttgcagata tttctcacac 813121 tgttgattct ttccgcacac tcctgatgtt cagcacgccc gcttttattt tcatctctga 813181 atttttactg gcccgttctt atcctgatgg ggtgcctgac ggttttttaa agaagcgggg 813241 aaaagtgatt tttgttcctt ttttatttat cgcagccatc gatgcgctgc tgatgaccag 813301 tgcgatgggg ggagaggtaa cctttctcgc gtttgtgcaa aaatatctgg cgaacgtatt 813361 cttaggaaac tttatcggat acttcattct cgtcatcttt caattttaca tgctgcatat 813421 gatgtttcat gagtatttga aaaaagcatc gccgaaatgg gtgctgtcta tctcatttgt 813481 ggtgacagcc gcttatttag gctatttctc cgcagccagc ccggctcctg cttctgaaga 813541 gggaggggca tttccgttct tctgggttcc gttcgcaggc tggcttttct acttttgtct 813601 agcctactat tgcggaaaag aatacaagcg ttttttagcg ctgctgaacc aataccgctg 813661 ggtggtgtac ggcgccgcaa ttgcttctgg ggcgctggtt gtcactgttt cttatgtcgg 813721 tgaaatcggc atgatcagct cgaagcggcc tgatatcatg ctgtattcaa caagcatgat 813781 tttcctgtgt tttcatttgt tttccaaaat gaagcatgtg ccgaaaatca tgatgtttat 813841 cagcaactat tccttttcga tttatctgct tcatgcctat tttatgatta taggctacgt 813901 gttgcttttg aatatgcccg aaattcctgc cgtaccggct gttctcctgt tgtttgccgt 813961 gtgcacagcc ggcccgatta tgacctcatg ggcgctgaat aagttcaaat acgggtattt 814021 atttgtgggg aaaatttatc agccaaaaca gaagaaggta acagtcgaag tgcgtgatca 814081 cgcagggtga aaaacaagcg gcaggagggc tcctgccgcg tttctttact tctcatccgc 814141 ttgcagaact gtttttaaat atagttttgc agactcagca agtccagata catcagcctt 814201 ttcttcatcg aaatacaggg cgttttgaat gatgccgtca ttcatattga ggaaaaactt 814261 ggcgatagtc gcaagaggct gaaccggctg aaactctccc tgatcgatcc ctttttgcaa 814321 tagccttgaa aacctttcca caaaaagatc ataccttttc tccaaatact gccgccgttc 814381 ttcattgcgc caagctgtca ctaaatattc aaattgcacc ggcgccagcg tatctgctac 814441 atctcgcagg ccctcagtca gttcatccaa atagctggaa atggaggccc aaacactttg 814501 gtgttcagct gatttatcaa gctttcggag tccttcatcc agccctgttt caataatgcg 814561 gcgaaacatc tcctcagtgc ttgaaaaata aagatagaca ccgccccggc tgaaacctga 814621 ctcttctaca acatccttca tcgtcgttaa ttcgaatcct tttcgtttaa aaaccgtttt 814681 ggcagcctct aaaatctctg cctgccgttt atccttgtgc tcctttgtta cttttggtga 814741 caagatatcg cctgctttct gcaattttct tacctataag tgtaatcaac ccaatcatga 814801 tcagcaagca gccacagaca agaaaagcaa gtgatacacc gatccattcc gccagcacgc 814861 ccccgcccgc catgccgagg atagaggcga gggttgtcgc actctgaata gcgccgaaca 814921 ccctaccgct gtaatcgaca ggcactgttg tttgcacgag aatctgaaat ggaatatgga 814981 cgaggccgaa agccgccccc atgatgaaaa aagcaaatat aaagagagtg atgccggcaa 815041 ttcccatacc gcttaggaat ggcgcacctc cagttgctag tccaagaaga agggttccag 815101 ctgagaaata aagcaaataa gaagtgattc gccgtctgcc ggtaatggcc gctgtaagga 815161 gcatcccggc tccgcttacg gccatgcacc agcctgccag ctcgggcgga gctcctgaaa 815221 aggagcggat aagaataatc gcttgggaat caccaatctg caaaacaaag agaacgacac 815281 aagctgttag taagcctgtt aatagaagcg gcatccgttt caaaaactga aggccttcct 815341 tgatagaagt aagtgctgct gttttttctt gaggtgtatt ggctttttgt aaaaaagcat 815401 ctctgggaag gaaaaacaaa atgacagcgg aaagaaagaa ggcgccggcg tttatataaa 815461 aaacagagtg tatcgagaaa gcagcgatca gcgtgccgcc aagggcaggg ccgaagattt 815521 ttgagctgtt atcaatgatg ctgctgacgg aaacggcctg ctgaatgtgt gcttccggag 815581 ccaattcctt aagctttccg tttttagcag gtaaaaaaag tgaagaaaaa cagctctgaa 815641 cggatagcaa tacgtaaagc tgccaaagct cactgacata aacgcagctg ataacagtga 815701 gggcacggcc gatttcagat agaaacatga tcgtttttct gtcaaaacgg tcggcaagca 815761 gacccgatac aggtccgagt acaatgacag gcaaagcaaa cgacatcatt aaaagcgaca 815821 tatctaatgg agaagcatga agctgaaaag cggctaatgt tagcacggcc aaaatgtgaa 815881 gccagtctcc aagtgaagaa atggtttgcg aggctaacag tgtcatcagt cctttttgat 815941 tgcgaaacaa cggtttttcc atgattcatc ctcctgatta ttaaaatgac actagtgtcg 816001 tttttaattg tatgggaaaa agacacaata tacaatcttt ttcttgtaaa ataaaggaga 816061 agattgaata gaagggagaa cattcatgac atcagtcaat ctaagctacc caataggaga 816121 atacaagccg agggaatcca tatcgaagga gcaaaaagat aaatggattc aagtacttga 816181 agaagtgccg gcaaaattga agcaagctgt agaggtcatg acggacagcc agcttgacac 816241 accgtaccgg gacggtggat ggaccgttcg gcaagttgtt catcatctgg ctgacagtca 816301 tatgaacagc tatattcgtt ttaaattgag cttgacggaa gagacaccgg ctatccgtcc 816361 gtatgatgaa aaagcatggt cggagctaaa agactcgaaa acggcagatc cgagcggctc 816421 actcgcgctt ttgcaggagc ttcacggaag atggacggct ctgctccgca ccctgacgga 816481 tcagcaattt aagcgcggat tttatcaccc tgatacaaag gagatcatta ccctggagaa 816541 cgcgctcggc ctgtatgtct ggcactcaca tcaccatatc gctcatatta cggagctttc 816601 cagacggatg gggtggtctt aacgcttttg ccggcggaaa gccggaatac tgatagcagc 816661 aatcaccaga agtgagacca cagcagccgc tgcatataaa tgatcatagc cgctggcgac 816721 actcgcatga atggcgtcgc ttatcgcggt tttgacttca ggaacgggaa tgcgttcgat 816781 ttgttcttgt aaagaagaaa cttcagaact gtcgatctcc ggaatcatct gcatcgcctt 816841 ttctgaatat ccgctgtccg ataagcggct gttgatctca tcacctattt ggtcaaaccc 816901 ggctgtgata aaacctgcat aaagagtagg cgccaaggtc agtccaattt gccttactaa 816961 tgaaagcgtg ccaagagctg tacccttatt tgtttttgcc gcttctgata caaggacgtt 817021 cagcggagcg cctaacagaa agccaaaacc gatcccagct gccacacttg cgatcacaaa 817081 ctcccatttt tccgtgaccc agagcggaaa taaagcaaac cccgcacatg agatgattcc 817141 cgaaagaata acggttttta caggaccttt tttgtcggta agtgctccgc caagccaagc 817201 gccgattccg gaagccaacg caagcggtgt catccaatag cctgcttttg cggcagggac 817261 acccaaatac tgttcgacat atgacgggat aaaaatgact gccgccaaga gccccccgga 817321 taacaaaccg atgataagcg tgcgctgaaa catatggttt cgcagcagag aatacgccaa 817381 aatgggatcg cctcctcgca tttcaactct cttttcatac gagataagcg ctgcaaaaca 817441 gagtatgcca aaaataatac atccataaac ctccggattc cccaagctgt gtaagagatt 817501 tgccccgtca agattggtca tgccgtacat cacagctaaa atcgacaggg acaaaaggaa 817561 gattccggcc gcatcgaggc gcttagcctc aggtgctttt gtttccgcga taaaacatgc 817621 gccgaaaaca accaatagca cggcaatcgg caaattaatc aaaaatagcc aatgccaaga 817681 cccggtccaa tcaagcagaa agcttccgat atttggcccg agcacagcgg ccatcccgtt 817741 cattgcgcca agcagcccaa gcgccttccc ctgtttttcc tttggaaggg tcgcgagaat 817801 gtgagagctg ccgatgatga aaatcccgcc gcctccaagc gcctgaatca gccgcgatat 817861 cagaaagagc gggaagcttt ggctcaaagc aacaagcaaa gaaccaagtc cgaacaggca 817921 aacctcaatg agaaagagtt tttttctgcc gtagcggtcg gaaagttttc cgacgattgg 817981 cacactgacg ctaagaccga gcgtataaag ggtaatgccc catgatcccc aggaagggga 818041 aacggaaaac gactcgttta tcgttgttaa agcagccgaa ataattccgt tatctaaagc 818101 agccataaac acgccaatcg taaacaggct gattgcccac ttttggcttt tctgctctgt 818161 taatgcttca gacattttcg tcaactcctt ttagttcact tgaaatatat tattcatttt 818221 aaatgaacta aatgtcaaat aaaaaaagcc tgctcccgca gtttgcggat gacagactta 818281 ctgatttatt cttttttcgc attctctaat gctcttgaaa ggatagacag cccttcgtaa 818341 acagcctgct tttcttcagg ggacagcagc tctaatgaac gcttcaattt caggtggccc 818401 ttttcataca aaccccggaa aatctttttc gcattctctg tcaactgaac aactacagag 818461 cggcggtcct cttcagaatg tgagcgtttg acaaatcctg atttttcaag ccggtcaagc 818521 agcccagttg tattggacag ggaagccccc attttttcag caatgtcgct cactttcaat 818581 gttccatggt tgtttaatag catcagcacc ttcatttgcg gcatgctcat atccagtttc 818641 atccactcgg acacatcacc gagcccggcg gacgttaaga ctttcatata gagcacccat 818701 atttcccgtt cctccgatga aagaatgttt tcgtttaaga ctgttgtatc gtgtaaatta 818761 tattccattt catcacttcc tcatcattca ctcctcttac catattactc gattttcact 818821 cctgaaagaa agtgagcaga aaccgcatgc gggactttgt ccgaaaaata acggtagtgt 818881 ataatgagtt ggagattatt gggggagagg atcgaactag aatatgattg gagagaccat 818941 tgctgattaa aaagaatgct ttatcaatat taaaaatcgt ttttcctatt gctgttttgc 819001 tatttgttat ttatcaatcg aaaaaagaac tgacaaatct gtcattcaaa cgtacgctca 819061 tggtcatcaa cggactggaa cgaacggatt tattcatgct tgtgttgatc ggcttgctgg 819121 ctgttgcggc tatgtcgctg tatgattacg tcctgaagta ctcactgcgc ctatcgatca 819181 caaacggaaa agttttcagg gtttcctgga tcgccaattc atttaataat gtgttgggat 819241 tcggcggttt agccggagtc gggttaagaa tgatgttcta taaggagcat acgaaagacc 819301 ataaggcact cgtgaaagga atcgcctggc tcacatcatc tatgctgctc ggattatctg 819361 ttttcagcat tttcgttgct gcgagagtgc tgccagttga tgaagtgatt catgagaagc 819421 cttggctgtg ggcggtcgtt atcggttttg cactgatatt gccgttatct ttagcggtgt 819481 ccaaaataaa agaccgcaaa gctggggacg aagagaatgc ggataaagtg aaaaatccga 819541 ttttcgcata tattggagct tcagttgttg aatggctcat ggccgggacc gtcatctatt 819601 ttgctttgtt cgctatgggc attcatgcag atatcaggta tgtgttcggg gtgttcgtca 819661 ttgcggcgat cggaggaatg atcagcctcg tgccgggcgg cttcggctcg tttgaccttt 819721 tatttttgct ggggatggag cagcttggct atcatcaaga ggccatcgtt acttctattg 819781 tgttgtacag gctcgcctac tcatttatcc catttatctt gggactgttc tttgccgccg 819841 gcgacctgac ggaaaataca atgaagcggc tcgaaacgaa cccgcgcatc gcaccggcaa 819901 ttgagacgac aaacgttctg cttgttgttc agcgtgcggt attagtgaga attttgcaag 819961 gctcgctttc ccttattgtg ttcgtagcag gtctgattgt cttggcctca gtttccttgc 820021 cgattgacag gctgacggtt ataccgcaca ttccgcgccc ggcgcttttg ctgttcaacg 820081 gcctgtcctt aagctcagcg ctcattctgc tcattttgcc gatcgagctt tataaacgga 820141 caaaacgttc ctacacgatg gccattacag cgcttgtcgg cggctttgtg ttcagctttt 820201 taaaagggct taacatcagc gcgatattcg tactgccgat gattatcgta ttgcttgtgc 820261 tattgaaaaa acaatttgtc cgcgaacagg catcctatac actgggacaa ttgatattcg 820321 ctgtggcgct gtttactgtg gcgctcttta actacaatct gatcgcgggc tttatttggg 820381 accggatgaa gaaggtgctg cgtcacgaat atttcgtcca cagcacctcg catattacac 820441 atgcaaccat catggcgatc atcattgtgc cgctgttctt cttgatattt acagtggtct 820501 atcataagag aacgaaaccg atcggagaga aagctgaccc tgagcgtctt gctgcgtttc 820561 tcaatgaaaa aggcggcaac gcgctgagcc atcttggttt tcttggagat aagcggtttt 820621 atttttctag cgatggaaat gcactgcttc tgtttgggaa aatcgccaga aggctggtcg 820681 tgctcggcga tccatctggc caaagagaat cattcccgct cgtgctggaa gaatttctga 820741 acgaagcgca tcagaaggga ttcagtgttt tgttctatca aattgaacga gaggacatgg 820801 cgctgtatca cgattttggc tacaacttct ttaaattggg tgaggaagca tatgtagatt 820861 taaatacatt taccttgact gggaagaaaa aagccggcct tcgggcaatc aataaccgct 820921 ttgagcggga ggagtatact ttccatgtgg atcatccccc attttctgat gcgtttttgg 820981 aggagctgaa gcaaatctca gacgaatggc tcggctcgaa aaaagagaag ggattctcgc 821041 tcggattttt tgatccttcc tatttacaga aagcgccgat cgcctatatg aaaaatgcag 821101 aaggagagat cgttgcattc gcaaatgtca tgccgatgta ccaggaagga gagatatcgg 821161 tcgatctgat gcgctatcgc ggcgacgctc caaatggcat tatggacgca ttgtttatcc 821221 gtatgttttt atgggcaaag gaagagggct gtacgtcatt taatatgggg atggcaccct 821281 tggccaatgt cggcactgcc tttacatcct tctggtccga aaggtttgcc gctgtcattt 821341 ttaataatgt cagatacatg tacagtttca gcggcctaag agcctttaaa gaaaaatata 821401 aaccggagtg gcgagggaaa tacttagcgt atcggaaaaa cagatctctt tctgtcacca 821461 tgttcctcgt tacacgtctg attggcaaaa gcaaaaaaga ctccgtctaa taagacggag 821521 tcttttttta tttcgttttt aagaagtagg tttcaatatc atcaagcagg tagtttgcgg 821581 ctttaattcc gcctgcggtt gtccatacga cgtcatcgac ttcatgtgca ttacctgact 821641 tcacggcctt caggtttttc catagtgaac tgcttgtcca ctgattggcc catttttcat 821701 tttcttttgc attatcggct ttataagtga aataaaacag cacatcagca tccatatcag 821761 gaatagattc tttactgtcg gttgagaacg taaattggtc cttttgtttc ttaaacagtt 821821 ccacttgttt ttcagggcgt ttgaagccaa gctggtctaa aataatccca ggaaatgaat 821881 cggtataata gattcttgat tcaccggata aaaagcgtac gactgaaacg gttttgtttg 821941 tctggtcgcc cagcttgttt tttaaatcag aaacacgttt atcaaaatcg gcaatgactt 822001 ccttgccttt gtccgcctta ttcaccgcgt tggcgtatag agtcaggtta tccttccagt 822061 tcccggccaa agattcagca aaaacagtcg gcgcaatcgc atttaactga tcataaattt 822121 tttcctggcg cactttgttt ccaataatca aatcaggctt taattctgcg atggcttcca 822181 cattcggttc cgtttcaaga ccgacgtttt taacaccttt catgtcatct ttcagatagt 822241 cataccacgg gtcgcccttc catgacttta cggctccgac cggcttaatg ccaagcgcta 822301 agagcgcctc tgttccttca ttagttaaaa caacaatccg ttttggattg gcggggatgt 822361 tgtctgatgt ccccattgca tgtttgaccg ttcttgtttt gctgcttgac acctcgctgt 822421 tgcttgaact ttctgaacta ttacaggcag aaagtaccat aacggccatt aaaaatacga 822481 atagcatgct gatatgcttt ttcatctttt tcctcccaat attgaaattc attatcattt 822541 agatcataat aagcagtgtt aagagtgtca atccctaatt gaggattatt ctcaaaaaca 822601 aacattacat agtaaataac taggagaatt agatcatgat ctgcaaaaag gcatcttcaa 822661 aatggattgt gttagtatgt ctgattttca ttttactgac ggctgtctgc gcaagcgtcg 822721 tgtatggcta tacaggtacg tcatggagac aggtctatca ggcgtttact tccttcaatg 822781 gaacaaatga gcatgtcatc atcaaggatg tcaggcttcc gcgcgctttg gttgcgacag 822841 tcgtcggcgc ctcgcttgca gccgcgggcg ctctcatgca ggcgctcaca aaaaatccgc 822901 ttgcgtcacc ggggattttc gggattaacg ccggtgcagg tttttttatt gttgccggat 822961 cgttttttct gcatattcag tcacctcagg cattagtatg gagctcgttt ctgggggcag 823021 catttaccgc tgcgatcgtc tatgcagcag gctcgcttgg gagggaaggg ctgacgccaa 823081 tcaaactgac gctggcggga gctgccatgg cagccatgtt ttcttctctg acacagggct 823141 tgctgtctgt caacgaactc gagcttgccc aggtgctttt ttggctgact ggctctgtgc 823201 agggccggag tctggatctg ttgatgacga tgtttccata tgcagcggca gcgctggtaa 823261 tctgcttctt tctcggccaa aaaattaatc tcctcgttat gggagaagat gtggcaaaag 823321 gactcggcca aaaaacaggc ctgctgaaat ttgtgatggc gctttgtgtt gtcatgcttg 823381 cagggtccgc tgtcgccatt gccgggccga tttcttttat cggcatcatt attccgcatt 823441 ttgcccgctt tgtcgttggt aatgattatc gctgggttct gccattttcc gctgttttgg 823501 gtgccatttt gcttgtttgc gcggatatcg gtgcgcgata tatcattatg cctcaggaag 823561 ttcctgtcgg ggtcatgacc gccatcatcg gaatgcctgt gtttgtgtac atcgcaagaa 823621 ggggggcgaa gctatgaaac ttcgttttgg cgttactgcg gctgaaaaga aagcatggat 823681 cgtctttttg gttttactgg ggttaacagc tgctgtactc atcataagcg ctggtctcgg 823741 acaaaggttt attcctccct gggatgtagc aaaaacattc tttggtgcag gttccaagct 823801 ggatgaactg atgatcatgt cgttccgcat gccaagaatt ttgacggctt tatgcgccgg 823861 tgtctgcttg gcagcggcag gcgcgatatt gcaggggctc gtcagaaacc ctctcgcatc 823921 tccggatatt atcggaataa caggaggagc ggcggtagcg gtcgtgcttt taatgatgtt 823981 cttctcagac cgcagcagtt cacttacgat cagtctgtca tggcttccag cagccgcatt 824041 tatcggcgca tcggctgtcg ggctcatcgt ctatttactg gcatacaaaa atggcgcctc 824101 cacatttcgg ctggtgctta tcggaatcgg attttcaatg tcggcgcagg cgatgactac 824161 cctgttgatg atcaaaggcc cgatttaccg agcatcacaa gccaatgtgt atatcactgg 824221 gtcagtttat gggtcaaact ggcagcatgt aaaaatagct attatcttat ctgtcattct 824281 cttattcatt tgttttgtcg cgctaaaaaa tatgaatata caggtgctgg gtgaagatat 824341 tgcggcgggt gcaggaagcg ctgtgcagcg aaatcgtttt ttcttgctcc ttttgagtac 824401 ggctcttact ggttgtgcag tttcagttgc cggcacaatc ggttttgtcg ggctgatggc 824461 gccccatatt gcaagacggc ttgtcggctc atcttatggc gcgctgctcc cagcgtcggc 824521 acttattgga gctctgctcg ttttaacagc tgatatcgtc ggcagaacct tatttgctcc 824581 ggtggaagtg ccggccggcg tctttacagc ggctatcggc gcaccttatt ttatttattt 824641 gctctataaa acaagaaatt cttaatcgtt acacccattt tcttaaaaaa gaaaatgggt 824701 ttttttgata atgactgaag attcgtaatt atttttgcta tactgacaga gacattgata 824761 aagaaagggc ggcagatgaa tgaaagaagc agaggtatta aaatatgaag catttacaag 824821 cagtcccggc aaaggaaacc ccgcaggcgt cgttttgcag ggagacgatt atacggaaga 824881 cgagatgcag atcatagctg aacgtgccgg gtattcagaa acctccttta tccgaaaaag 824941 cgagtcggcc gatcttgaac tccgttactt tacccctgga cacgaaatga atttgtgcgg 825001 tcatgcgaca gttgcttctc tttacgcatt atgtgagaaa ggaatgctgg agagcggtaa 825061 aacgtacagc atccaaacga aagcgggtat cctgcctgtg aagatttctg aaaaagatgg 825121 ccgcattcat atcacgcttg aacaggcctc tccgcaattc aaaccattta caggcgatcg 825181 gaaaaaactt gcggacgcac tgggtatcac cgatgaagat tttcatgaag accttccgat 825241 tgtgtttggc agcactggga tatggacagc catcgttccg cttaaatcat tggaggcttc 825301 caaaaaaatg gtgccagata acaaacaatt tccggaagtg ttagttgatc tgccaaaagc 825361 ttcagtccat ccgtttacct ttgaaaccgt ccatcccgac agcgacctgc acgggcgcca 825421 cttttcatcc ccgtattcgg gaacgattga agaccccgtg accggcacag catccggcgt 825481 gatgggggct tatatgaaac attatggcaa tgccgagcag cataaattta tcattgaaca 825541 agggcaggaa attggaaaag acggaaaagt ggagatcgaa atgaacgaag ccggcggcca 825601 tgtgaaagtg aacatgacag gaacagccgt ttactcagaa acccgtattc ttaaaatcta 825661 atacggatga tggtttacaa aaagatgcac tttccgttat cattatgaaa tgataatcat 825721 tttcaattgc ataggaaggt gagacggtat gcctcaaacc gaacaaatac atcagcattc 825781 agtactgagg gacatcatac gcagcagaag atcgattcga aagtttaaac aagagccagt 825841 accttcagca gtcattcttg acatgcttga aacggcaaaa tatgcgccaa atcacagagt 825901 gacagagcca tggagattta tttacgtttc cagtgagaca ggtaaagcga acctcattaa 825961 tacatttgca gcgttctcta agaaatccaa gccggatatg acagaggaaa agcttcaaaa 826021 tttcaaaaac acacttgggc gcgttccggg atttctcctc gtcgtgtttc aggaagatga 826081 aaacgaaaga gcgcgggacg acgattttgc ggcaacaagc tcgttgattc aaaatcttca 826141 gcttctcgct tgggaaaaag gaatcggcat ggtttggaaa agcggaaaaa tcctttatga 826201 caaagaagtc catcaggcct ttggtttaca ggataatgag cgtttcgccg ccatcataca 826261 aacaggttat cctgacgagg cgccggaagt gaaaaaacgc acaccgatcc gcgaccgatt 826321 cactgaaatg taaaaaaccc cttgtctcaa acggagacaa ggggtttttc attaacgaga 826381 tttctttttc gctctgttgt cggctgcttt cgcacgctct tgcgcttcgc ggtcatctgc 826441 atcagcaagc tcggttgaat attcttcgta aacgccgtca gtttcccttt ttaaggcatc 826501 gggaacttgt ggaagctttt gtttgttttt atcacggttt ttgtggatat gatttctgcc 826561 catatcaaat tccccctaaa aagtgatatc aaacaaatat agtatttggt tttaaggggc 826621 tatgtattcc tacttccgct tagcagcttt ttccgctttt ttaaattcgc ctgaataaag 826681 aacttcctgc atttttttca ggttggcgcc ttgctggtgc ttctccctct ttttttccat 826741 aaaaaggacc tccttcaacc atgttattct taaggttgac gcttcctgct gtttttatac 826801 agtctttcgg tccgctatca gctgtgagag tgcaaattca agatccgaat atgtaaaacg 826861 aaatccagag gttatcgctt ttttcggaag agcgcgctgt cctttcacaa tcaaaagact 826921 catttcaccc aatgcttttg ataaaaagaa ttccgggacg gggagccagt gcgggcggtg 826981 cttcacccgt gcaatcgttt ttccgaattg cttcatgtcc acaggattgg gcgcggtgac 827041 attcattggg cctgagatgc cggcgttttc caccgcatat cggatcatct gggccgcatc 827101 ctcgacatga atccatgaca gccactgcct tcccgttccg atcgttccgc cggccagaaa 827161 cttatagggg agaatcatga gcgggagagc gcctttttct ccaagcatca cgccaaatct 827221 cgcataaact gtccggatgc ccatcgcttc aatatgctgt ccttcctttt cccacaggtg 827281 tgcagtatgg ctgagaaaat cctcatctga cgttgcagaa tcctctgtga aagttttctc 827341 aaggcttgtg ccgtaaatgc ccacggcact ggcttggatc aatgtcttcg gcttctcctt 827401 ctgtttctga ataagccgct gcacttcacg cgtcgcattg atacggctgg agagaatgtg 827461 ctgcttcgtt ttttctgtcc agcggccaaa aatcgatttt cccgcaagat ttatccagac 827521 atcaatatga ggaagttcct gctccggtgc ggctccttcc gacagccatt ggacatatgt 827581 catatttttt tgttcagttt cccttgcgtt tcttgataaa atataaacat ggtgtccctg 827641 gcgggtaaga acgcctgtca gatgctggcc gagaaaaccg gttccgcccg tcattgcgat 827701 attcatgaac atctctcctc atcgttctaa taaatatact ttacctcatt gtaataaaag 827761 aaaacgcgtt tcaggcctga gaagggagat taagatgccg tttattacaa aaatatcaac 827821 gcaaaaaaag aatacggaac gcttcaatat ttttctggat gataaatacg ccttcagcgt 827881 ggacgcggat gtgctcgtga aatttgagct caagaaggga aaagaactcg atgatcttga 827941 catcattgag attcaatacg gcgatgaagt gaagaaaggc ttcaaccgtg cgcttgactt 828001 tttatcctat cgaatgcggt cgacgaaaga ggtcgaggat cacttaaaga aaaaagaaac 828061 ctcgcccccc gtcattgcgg aagtcatcca taggcttaac gattacaagt acttaaacga 828121 ccaggaattt gccgcagcct atgtcagcac tcacaaaaaa acaaacggaa aaggccctga 828181 tgttttgttc agagagctaa gagcgaaggg aattgatgac gatacaatta aggaggcgct 828241 aagttccttt tcctttgaag atcagacaag agaagcggtc aagcatgttg aaaagcttct 828301 caaaaaagat aaaaagcttt cgacgaaaga actcaaacag cgcgcccagc tgcagcttca 828361 gcgcaagggc ttctcatttg atgttatcag cgcggcgatg gatcagattg aatatgaaaa 828421 tgatgaagac acagagaaag aagcgctgcg ccttcacgcg gaaaaagcgt ttagaaaata 828481 ccgctatgac ggctcatatg aaagcgccat gaaggtcaaa caatttttat tccgcaaagg 828541 attctcactc gatttaatcg agcaattact gcaggaagag gagtactgaa atggagaaac 828601 gatacagtca aatgacaccg catgaactca ataccgaaat cgcattactt tctgaaaaag 828661 caagaaaagc cgaacagcat ggaatcataa acgaactggc agtgctcgaa cggaaaatta 828721 cgatggcaaa agcatatttg ctgaacccgg aagattactc accgggagaa acatatcgtg 828781 tggaaaacac tgaggacgag tttaccatca gttatttaaa tggcgttttc gcatggggat 828841 acaggacctc ttcccctcag caagaggaag cgctgccaat ctcagtattg caagaaaaag 828901 aataaagcgt aacaggaggc tgatgatcag cctctttttg tttgcagcac atttacacga 828961 attcttaaag aaaaaatcat tgaattcact tgaaaaatct tttaagatga aactcgttgt 829021 tttttaaaat caaaggaggc gatgacgttg agtatcaaaa acccatctgt aaaatttatt 829081 atatttgttc ttatgatttg tacattttca atcggctata cagaatacgc ggtgatgggt 829141 attttgacgt cgattgccaa tgactttcat atacaggttt catccgcagg gcttcttgtc 829201 acggcttatg cggcaagcgt ttgtttgaca gggccgctcg tcaccatcat ttccgtcaag 829261 cttccgagaa agcctgtgct tcttgggctg atggcgatat ttatcctttc caacctgatg 829321 agcgcactgg cgccgaattt tgcggtattg gccatttcaa gaattttatc tgcgtccatt 829381 cacggcgctt tcttcgcgat tgccatggta ttcgcaagtg aaatggttcc gccggaaaag 829441 cgtgctgcag ctgctgcttc aatgaacggc ggactgacag tggctctaat gcttggtgtt 829501 ccattcggct cttatctcgg agatgtcctg aattggagag cggtgttttc catcattacg 829561 gcacttggtg tcatcggatt tttaggcctt atggctgccg tgccgaacag aaaaccaaaa 829621 gtgatcccaa tgcttatgaa tgagtggggt gtttttaaac acaaacaagt gctgttttcc 829681 ttcgcgatta ccattttagg ctattccggt gtctttatcg cctacacctt tatcgaaccc 829741 attttgaggc attcagccgg attcagcacg gttggcatta caggtgctct ctttgcgtat 829801 ggattgggag gcgttgccgg gaatttcttt gctggaaagg taccgctgcc tttgctgact 829861 cggacgatga tcggcgtaat gatcggttta atcggtgttc tggctgtatt tccttacatc 829921 gccatttacc cggctgcagc cattgtggca acgttcctat tcggggcatg cgcattcggc 829981 acgccgcctc ttctgcaaac aaaggtcatt tcctcatctg agggcggcac aaccattgcc 830041 gcagctgtca gcgtatcagc atttaacctt gccaatgccc ttggtgcatg gatcggcgga 830101 atgattttaa acggaacagg ctcttattcc tggctgtttg caggaggtgc gcttatgacc 830161 gcatgcggac ttgtgctttc taccttcgca cacttatcag aaaagaagag cgtctacgaa 830221 tatcaagtca ataaagggta aaaaacagct gcagtgtatg cagctgttct tctttaccgt 830281 ttgcctgagg ctctcattct ttcttgagga tgctgattga tagatccgtc agcacgcttt 830341 gaagcatagt cgtcctttgc tctcggttca ccctgaaatt tgttttcgtt ttcgtaagga 830401 aatccttttt ctttatttcg gaccatgtca tatcccccta ggttcgagat caaaaagttg 830461 cgtcttttca gatgaagacg taaggttagt atatggagaa caccacgtaa taaagcgtta 830521 tttttttcct gaagaaagga gactgcacac atgaatatgt acattgagaa actgactaat 830581 ctgcttctgg aaaagaacga gatgatcagc tatatacagg caaaaacgtg ggtggaattg 830641 ttatggagcg atttcgaagc aacctacgca aaagccggac acgcctatca aggtgaaaaa 830701 atgactgaaa aaatcgtcac acaatggatt gaaaactatg gcggccagct ccaccttttt 830761 caaagctccc gtaacgacgt gaatgattac ttaaatcaaa gcagaggcct tttgcattaa 830821 aaacctgccg ttaacgaccg gcaggttttt tcattttctt aaaattacct taacaggaag 830881 aaatcataaa caaaacatgt ttcaccagcc tgtcaatcag ggaataccac ttatatcttg 830941 tcaaaatgcg aggaggagct ttatatgaaa aagaaacaag taatgctcgc tttaacagct 831001 gccgcaggac tgggtttgac agcacttcat tccgctcccg cagcaaaagc tgcgcccctt 831061 cacgacatat ctgtcagcat gccatcatcc gatacttaca tcataaaagc aggaaagctg 831121 aatgtccgga ctgagccaaa tcatgaaggt gatattctcg gcactgtatc atcagaacaa 831181 aaggtaaaag tcgataggtt cgtaaatgcc gattgggctc aaattcattt caaaggaaag 831241 aaagcatata tttcaactca ctttttaatg aaaaccgcaa gccaagcgaa aacaacgaaa 831301 cagacagcct tctatacacc gacgcccgaa aacggaaaag ctaagcagct ctcatctgga 831361 acagaggtga caatacttgg gtggggattc agtgaaaacg gcggatttga cttcacttgg 831421 gcgttcgtgg attatggcgg agttaaaggc tatattcaca caaaggattt acaaatgcga 831481 taaaaaggca ggccgaggct tgtctttttg cctatgcatg aaacatttct tctttctgca 831541 cgtaacaatg agaaaggaga tgatgatatg acgggtttag tcggcggagg gcttatgatc 831601 attgcgggca tactgatcaa actgtttcct cccaaatcga tcaacagtgt gtacggatac 831661 agaacgagac gctcaatgtc agatcaaaga ttatggaatg aagcgaaccg ttacagtgca 831721 tcattaatga tcctgtcagg cttggtgatt gcgggaatgg gtttgctgct gggatcaaac 831781 ttgtttattc ttcagcttat cctgctgatt gccgcctgtg tcataacatt tatgctaacg 831841 gagaaaaggc tgaaaatcat gacgcacagt caaggaggag atagaagtgg acggagttaa 831901 atgccagttt gtcaatacga acggaatcac gcttcacgtt gcagccgcag gacgggaaga 831961 tggcccgtta attgtcctgc tccatggatt tcctgagttt tggtacggct ggaaaaatca 832021 aatcaaaccg cttgttgatg cgggttaccg ggtcattgct cctgatcagc ggggctacaa 832081 tctcagtgac aaaccggaag gaattgattc gtatcggatt gatacattaa gagatgatat 832141 catcgggctt attacgcaat tcactgatga aaaagcaatt gtcatcggtc atgactgggg 832201 aggagctgtc gcatggcatt tggcttccac acgcccggaa tatcttgaaa aactgatcgc 832261 gatcaatatc ccgcacccgc acgtcatgaa aaccgtaacg ccgctttatc cgccgcaatg 832321 gctgaaaagc tcgtatatcg catacttcca gctgcccgat ataccggagg catcactaag 832381 ggaaaatgat tatgatacat tagacaaagc gattggatta tccgaccgtc ccgcgctttt 832441 tacatccgag gatgtcagca ggtacaaaga agcgtggaag cagccgggcg cgctgacagc 832501 tatgctgaac tggtacagag ccctcagaaa aggaagcttg gcagagaaac cctcttacga 832561 aacagtacct taccgaatga tctggggaat ggaagaccgc tttttgagca gaaagcttgc 832621 gaaagagacg gaaaggcatt gcccgaatgg acatctcatc tttgttgatg aagcttccca 832681 ttggattaac cacgaaaagc cagccatcgt caatcagctg attttggaat atcttaagaa 832741 ccaataagct aaaatttctc tccatccgtc tgtcataatg gcagactttt tctgtgcgtt 832801 ttttttcata gtctgtttta aacatgacaa aataacatta aaaatcatga atgtcaccat 832861 aaaattgtaa caaaaaacag gtttaaacga ctttaaaaaa aggaatagcc ttactgaaga 832921 tttgtgtaaa actcccctaa ggcaatactt aaaaagaata ataaaaagaa ggtgccttaa 832981 tgaagcaagg attaatctcg attattatcc cgtcttacaa tgaagggtat aatgttaaac 833041 tcattcatga atctttaaaa aaggaattta aaaacattca ttatgactat gaaatattct 833101 tcataaacga cggaagtgtt gatgacacgc ttcagcagat caaagacttg gcagcgacgt 833161 gcagccgggt aaaatatata tctttttctc gaaactttgg aaaagaagcc gcaattttgg 833221 cgggctttga gcatgttcag ggcgaggcgg ttattgtcat ggatgccgat ctgcagcatc 833281 cgacatattt gctgaaggaa tttatcaaag gctacgaaga agggtatgac caagtcattg 833341 cccaaaggaa cagaaaaggg gacagctttg tccgctcact cttatcatct atgtattaca 833401 agttcattaa taaagcggtg gaagtcgatt tgcgtgacgg tgtcggtgac ttcagattgt 833461 taagccgcca agctgtgaat gcacttttga agctgagcga aggaaaccgc ttctcaaaag 833521 gccttttttg ctggattggc tttgatcaga aaattgtatt ttatgaaaat gtcgaacgaa 833581 aaaacggcac ctccaaatgg tcgttcagca gtctgtttaa ctacggaatg gacggcgtcg 833641 tttcatttaa tcataagccg ctgagattat gtttttatac aggcattttc atcctgctgc 833701 tttccatcat ttatatcatt gccacattcg ttaaaattct gactaacggt atttctgtgc 833761 ctgggtattt caccattatc tcagcagtgt tatttctcgg cggagtacag ctgttaagtc 833821 ttggaataat aggtgaatat atcggccgaa tctattatga aacaaaaaaa cgcccgcatt 833881 atttgatcaa agaggcgaat atcccgaaca aagacctgcc tgaaacgaac gaattaaaaa 833941 gcatgcggcg tctgacaaaa atgcactgaa aataccaagc gccattggca gtgctttttt 834001 tgcgtgtcta ttatcttaaa agcaagactg gagaattcat atgaaaagaa aacatatcat 834061 gatctatgcg gccagtttgc tggtgtccgt tctggcacac gctttttttg tgaaagaatg 834121 ggcggaaggc aggtatatga caggtccggg tgacgggctt gcgcaaatga tcgtatttaa 834181 aaaattatta tttgaccaat atacacacgg gaattttttc tacaattatt cattcggact 834241 tggcggcggc acattcagtc agctcggcta ttatttttct gcgtcttttc tttttcttgc 834301 tgtgtctgcc gctgtttggc tgcttcaagc cgtccagctg atcggagaaa cggatacgct 834361 tttttgggca gagtcagctg tttttatcag tattttcaaa ttgagcttga tcatctttac 834421 gtccgcttct gtttttcatt atcttcttaa gcacagggcg gcatcgttca cgggagccgt 834481 gttatacggc gtctcaatta tttatttccg tcacgaagcg tattgggaat ttttcaccga 834541 tacaatggtt tggcttccgc tgcttgtgct tggcgcagaa aaaattatta gagagcggcg 834601 tccggcgtgg tttatcgttg cgtgttcgct gacgttaatc aacaattttt actttgcata 834661 cataaacctt atattcatcg gaatctatgt gctgttcaga tggctgatcc gtttggaacc 834721 acatgaagag aaaagatgga ttcaaatcag attatttctc gtttcaggct tcatttcttt 834781 tggcatcagt gcggcggcgt ttgtgccggt agtatacggt tttttaaaca acctgcgccc 834841 tccatacagc cagaaaatag agtggctcaa tttcgatgat aatatcttat tttcgagccg 834901 gatcatcatt gtgccggccg cttttctgct gtttttgttt attatttctt tttacaaaaa 834961 ccgtgtgttt cgtctctttg ccgggttgag cctgctgttt attctgtttc atttcagtcc 835021 gtatgcggca agcgtcttta acggtttttc cgccccgcaa aaccggtttg aatatgttct 835081 ggcctttacc attgcgggag cagctgcggc tggtttgtca cagctgtctg aattgaaacg 835141 gaaagaactg ctcccggccg cagctgtcgt cctgcttctt tacttgtatc atatccaaag 835201 gtataagctc gatatatgga agcctgcgaa tgaaagtatt ctattgctct tactcatgac 835261 aatcgcagcc ttgtttgctg cagcttttgc gaaaaaacgg gcaaaaatgg ctgtgtacgg 835321 tataatcatt ctttcttcgc tgtttgtcgc caactcctat caaaaatacg cgctctcaga 835381 aggcggcgat ttggacagtg tgacaaaaga atatcttaca agtgaggaat acagagggcg 835441 ggaatcatct gagctcatca gacgtttaca gaaggaagac gatgacccgc tcatgagaat 835501 cgactggatg aacggggtcc gcaataatac gccaatcatt tacggattta atggcttcag 835561 cgcgtattcc agcattttaa acaaagatct gctggccttc tattggaatg atttaagcat 835621 cgatatgggc agggaaagcg tcagccgtta cgcgtcattg ggagacaggg cgaatttata 835681 cagcctgctt tacggcaaat attatatgac cgaaaaaaca aacgaagcca gcgtcccgta 835741 cggcttcaaa aagcatttag aaacagagca ttatgcagtt tatgagaatc agtacatgct 835801 tccattcgtt aaaacagcgg atgccatata cagcgaaagt gagctggacc gattgcccgc 835861 tcttgcgaaa gaacaggcga tgctgaaagg aattatatta aaagatccat caggaaaaac 835921 ggagcagaca ccaaaaccgt ccaatttgat caccaagtcg gacatcaccg caaaacaagc 835981 ccagtatcaa aacgggctgc taaccgtaac tggagaaaac ggaggagagc tgatcatcac 836041 cccgaaacag ccatcatccg ctccgggaga ctactatgtc agcttttatt tgaaaagcaa 836101 agcaaaagac aaaggattta cattaaaggt aaatgattat gtcacaacaa ggaaatcgaa 836161 caaatcgatc tataaaaccg gagtaaataa tataacggta agagtgccta aatcaggcca 836221 tatctcaatc aatcttccga aaggaaccta tgagctgaga aacatagcgc tctatgaaga 836281 aaattaccaa acgctgaaaa acgctgtaat gcaaaataaa acagagaaag cagacaaact 836341 gaattggaac aaaaatcgac tgaccttttc ctatcatctg tcaaaagacc agtacatcat 836401 gcttccgatc ccatatgaaa aaggctggga gctgaagatc aacggaaaaa cacagaagat 836461 cgaaaaagcg gattatgctt ttataggctt caaggcgcaa aagggagaca atcacattga 836521 gctgacttac tatccgccat acttcaaaat atcggcgatc atatctctcg tcagtctgct 836581 gcttgctgtt ttttatataa gacgtaaaaa gcccggctct atatagagcc gagctttaat 836641 tttttctgaa gtttttcttc gctgaatatc catcccgtat aggatgaacg aatcgtgaga 836701 tcatggccga tatgaacaat tgcgacaaac ggataatggc ctttgctccg ataacgcagg 836761 tcgataaatc tcacctcata atgatcttta aacgtatcca cttcccaccg gtataccgga 836821 gaaaaggaca gaaacgccgc gatgttatca tcctgctttg ccgcatgcat tacatcggtt 836881 tcaggaacag gcacccgatt aaatgtatcc agaatcacga catgtccttc catgcttctt 836941 cctacataga aagcatgtgc tgtcgtcact gcgattcgcc attgcctgaa tttcatcgtt 837001 ggagaaataa taatgctttc gatctcatca tgaatcatct catgaagctt ccgtttaatt 837061 ctcagctgca tgatcaggcg caccaagtag tagcctacca atatgatata taagctgaga 837121 aacgtgatgc cgggactccc gcctgcatac caaatcgcga tagctgccag atggctgata 837181 aaaataaacg gatcaaacgt attaatcagc ccgagcgcaa cccatttttt cgaaaacgga 837241 cgaatggctt gtgttccata ggcgttgaat atatcaacaa agacatgcag aacgactgcc 837301 agcagtgtcc acagccacag gtgcagaaaa tcggcctgag gataaaataa atacagaatc 837361 gccgggatga tgacagacca aaacaaaacg gcgggaattg aatgggtaaa tcctctgtga 837421 ttccttatat aaacagcatt gtttttaagc tttaacacag tatcaatatc cggagcctga 837481 gagcccgcaa gcgttgcgat cataacagcg tgagccattg ccggatctga tccgacaaca 837541 ggatcaagcg tcgcaatacc gcccagtgcg atgcccataa cgacatgtgt gcccgtatcc 837601 ataggtgacc tccttgcagg gtgatcctgc acattcactt tgtaagaaat tccccatttt 837661 catataccca atttttaaac tgattcaatc gttctcatat gtttccgctt tttctttatt 837721 actatttaat gtaacatatt atcgtactgt gcccttagtg tacaacaaaa aacagtctaa 837781 agaaaagcgg ggcgcgaaag actggggaga aacacatatg aacgtacttg aagacaaatt 837841 aaaacaaaaa gacatacagc aatttcgcga tgatttaatc tcatggtttg aacgagagca 837901 gcgcgttttg ccgtggagag aggaccaaga tccatataag gtgtgggtat ctgaagtgat 837961 gctgcagcaa acgagagtag agacagtgat tccttacttt ctccggtttg tagaacaatt 838021 cccgacagtg gaagcgctcg ctgatgctga tgaagaaaag gtgctgaaag catgggaagg 838081 gctcggctat tattcgcgag tcagaaacct gcaaagcgcg gtaaaagaag tgaaacagga 838141 atacggcggc attgttcctc cagacgagaa agattttggc gggttaaaag gcgtcggccc 838201 ttatacaaag ggagcggtgc tcagcattgc ctacaataaa cccattcccg cggttgacgg 838261 aaatgtgatg cgtgtcatgt ccaggattct atctatttgg gatgatattg ccaaaccaaa 838321 aacaagaacg atctttgaag acgccatacg agcttttatt tccaaagaaa aaccatctga 838381 atttaatcag ggcttgatgg agcttggagc cttgatctgt acgccaaaat caccctcatg 838441 cctgctttgc ccggttcagc agcattgctc agcatttgaa gaaggcactg aacgggagct 838501 tccggtaaaa agcaaaaaga aaaagcccgg gatcaaaacc atggccgcga tcgtactgac 838561 tgatgaagac ggacaagtgt atatccacaa acggccgtct aaaggtttgc tcgccaacct 838621 gtgggaattc ccgaatcttg aaacacaaaa agggatcaaa actgagcgtg aacagctcat 838681 tgctttctta gaaaacgaat atggcataca agctgatatc agtgatctgc aaggtgtagt 838741 cgagcatgtt ttcacccacc tggtatggaa tatttcagtg tttttcggta aagtaaaaca 838801 agtgtcggat accagcaagc tgaaaaaagt aacgaaagaa gagctcgaac aatttgcgtt 838861 cccggtgtca catcaaaaaa tctggaagat ggcaggagaa gcagccgcca tctcggctgc 838921 tccgtaaacc attcttaatc gtaagagacg cgcgtgccgt ggctgtagtc cgcttcattg 838981 cgcttcattc cgccgcgcgc ttcaatttct tgcgttaatt cccggtattt tgattggcct 839041 tcttcgttca aataaggcat aatttgctga aaggcatgat gaaaataagc gagttcactg 839101 ttcttccaat cttttttgga aaccatgttc aattcgctca tatcacgtcc gacatacata 839161 acagaagacc ccctttaaag ttcttgccat tattgtttgt ggaaataaaa gaactatacg 839221 ctacaaggag atgaggaaaa atggaacaaa ataaatgtgc actcgtaaca ggaagcagcc 839281 gcggtgtcgg aaaagcggcc gcgatcagac ttgctgagaa cggctataac atcgtcatta 839341 actatgcacg cagcaaaaaa gcagcattag aaacagcgga agaaatcgaa aagcttggcg 839401 ttaaagtgct tgtcgtaaaa gcaaacgtag gacagcctgc aaaaatcaaa gaaatgtttc 839461 agcaaattga tgaaacgttc ggcagacttg atgtttttgt caataatgcc gcttcaggag 839521 tactaagacc tgtcatggaa ttagaagaaa cacactggga ctggacgatg aacattaatg 839581 cgaaagcatt gcttttctgc gctcaggaag ctgccaagct aatggagaag aacggtggcg 839641 ggcatattgt cagcattagt tcattaggct ctatccgcta tcttgaaaac tacaccacgg 839701 tcggtgtatc aaaagcagcg ttagaggctt taacccgtta tcttgccgtt gagctttcac 839761 caaaacaaat tatcgtcaat gctgtttcag gcggagcgat cgacacagat gcgctgaagc 839821 acttcccgaa tagagaagat ctgcttgagg atgcgcgcca aaatacgccg gcgggacgca 839881 tggtcgaaat taaagacatg gttgatactg tggagtttct agtgtcttcc aaggctgaca 839941 tgatccgcgg acagacaatt atcgttgacg gcggacgctc actgctcgtt taaaaatttt 840001 taaaaaagag gaatagctat acgatcacct gcacattcta atgaccgtgg aggtgataac 840061 aatggctaac tcaaataact tcagcaaaac aaacgctcaa caagttagaa aacaaaacca 840121 acaatcagct gctggtcaag gtcaatttgg cactgaattt gctagcgaaa caaacgctca 840181 gcaagtcaga aaacaaaacc agcaatcagc tggacaacaa ggtcaattcg gcactgaatt 840241 cgctagtgaa actgacgcac agcaggtaag acagcaaaac caatctgctg aacaaaacaa 840301 acaacaaaac agctaatcac tgaaacagaa aaaagcactt catcttcggg tggaagtgct 840361 tttttctgtt tgaaaaacga caaaacttgt ggaaggtcta cagaatgagt caaagggttt 840421 gctttatgga gatcgaaatg attaaaggag gaaatgttta tactttcatc aggctgaagg 840481 aggaaccgat gaccgaattt gaaaagctgg taagtgaaca gatgaaaacg atggataagc 840541 ttctcgatct ccaatcagag ctcgaccgct gcaaacaaat tgaggcggaa ctccggcatt 840601 tggaaaggga tgcaaggctg cgtgggattc aggctgaaat tgcggtaaaa cggaaacacc 840661 ttgccgatat acaggatatg tttcaaaagc agacagagca ggtcattcgt tcatatcgca 840721 gctcagaaaa gccgtcttcc tttgtgtagt gcaggaatgt gccattcccc ggccggaatg 840781 gctcttttat tttcattttt caatttgtaa cgttataata ggtaaaagac gttgtcggta 840841 agcaaatttg gacatactaa ctgtagggct ttatagaaag taggggagaa atatgggcta 840901 tcccaaggaa ggagaaacca ttcaaattca cagctataag cacaacgggc tgattcatag 840961 aatttggaat gagacaacaa tcttaaaaag tacagaaatg tgtgtcatcg gagccaatga 841021 ccggacgatg gtaaccgaat cagacggccg gacatggata accagagagc ccgcaatctg 841081 ttattttcac gcaagacaat ggtttaatgt catcgggatg ctgagggaag acggggttca 841141 ttattattgc aacatcagtt ctccgtttgc ctatgatggc gaagcaatta aatatattga 841201 ttatgactta gatgttaagg tttttcctga catgacctac aatattctcg atgaagacga 841261 atatgatgat catcggaaag ccatgaatta tccaaaagaa atcgacagta ttttaagaga 841321 ctacttaaat acgctgctcc attggattca ccagcgtcag ggaccgtttg cgcccgagtt 841381 tgtcgatatg tggtatgaac ggtatttgcg ctatacaaaa taatggttac gtaaaaacct 841441 gttgcggggt acaacaggtt tttcacatgg gctcacacac atcatgataa agagagaggg 841501 ggaatcaacc gtgggggtta tgaaacgcta catgcaattc gtcaaacctt ataagaagca 841561 aattttcgtt acagtgttaa tcgggatcgt aaaattctcc attccgcttg ctctcccatt 841621 gcttctgaag tacgtagttg acgacattat tcaaggaggc ggcacggcca gtgacaaaac 841681 cacgtcattg ttcacgatta tggcgatcat gttcgcctta tttttaattt tgcgcccgcc 841741 tgttgaatat taccggcaat attttgccca gtggactgcc agcaaggtgc tttatgatat 841801 aagagctaag ctgtttgacc atatacaaaa actgagcctt cgtttttacg cgaatacaag 841861 aacaggggaa gtcatttccc gagtgattaa tgatgtagaa caaacaaagg atttcgtcat 841921 cacagggctg atgaatatat ggctcgatat gctgacgatt ttgattgtaa tctctatcat 841981 gctcacactg gacgttaaat taacgctgat ctctatcgtt ttattcccat tatacggaat 842041 atcagtgaag tatttttacg gccgtttacg aaagctgaca agggagcgct cacaggctct 842101 tgctcaagtg caggggcatt tgcatgaacg cattcaaggc atgcctgtca tcagaagctt 842161 tgcgatagaa gatcatgaac aggctcaatt taatgagaaa aacggtcatt tcttagataa 842221 agccatccgc cacacgaatt ggaacgcgaa aacctttgcg gtcgttaata ccattacaga 842281 tttggcgccg ctcatcgtca tagcgtgcgc cgggtatttt gtcattaatg gaccgctgac 842341 agtcggaaca atggtcgcgt ttgtcggata tattgacaga atgtacaacc ctgttagaag 842401 gctgatcaat tcctctacaa ctttgacaca gtcaatcgca tcaatggaca gggtgtttga 842461 atttattgac gagccctatg aactcactga caaaccaaat gcgataaagg ccgatcagat 842521 tcgcggagga gtggagtttc aaaacgtttc gtttcaatat gagaaggaca aagaaaatat 842581 tcttcatgat gtatccttaa aagtaaatag aggagaaact gtagctctcg tcggcatgag 842641 cggaggagga aaatcaacgc tcgtcagcct gatcccaaga ttttatgatg taacaagcgg 842701 cagactgctg attgatggga cggatattcg cgattatgaa gcaagaagcc ttcgcaacca 842761 ggttggtatg gtgcttcaag ataccttttt atttagtgaa acgattcggg aaaatatcgc 842821 gatcggcaag cctgatgcca cacttgaaga gataatcgaa gccgccaaag ctgcaaatgc 842881 ccatgaattt atcatgagtt ttccagaagg atatgagacc cgggtggggg aacgaggcgt 842941 taagctttca ggcggacaaa agcagcggat ctcaattgcg cgggtattcc tgaaaaatcc 843001 gccgctcctc attttagatg aagctacatc agctctggat ttggaaagtg agcattacat 843061 tcaagaagcg atggacaaac tggcgaagga tagaacaact tttgttgtcg cccaccgttt 843121 atcgacaatc acccatgcgg ataagattgt tgtcatggaa aacgggacaa tcattgaaat 843181 cggaacccat gatgaactca tggactatga gagccaatac aagcacttat ttaccattca 843241 aaatttgaac taaaacatca atcttatatc cttttaacga aggatataag atttttttgt 843301 atataaaaaa acccggctgt ttaaccgggt tactcttctg tttctatttc gcagtctttc 843361 ggatgatacg tttgaaaact tgtgataagt gtttctaaat gttcaagctg ctcgcgatat 843421 tccacggcgc ttgccataat attgagcatg ttgtaatcaa taagctcctc atccgtattc 843481 tgctgatttt ttaaaaatga ctttgttaaa agctgcttat accggatgcc ttcttcaacc 843541 gcgtcatcat gcggcttgat ttttccgaca aacctcatca aaatccgctc gtgccagtaa 843601 agcaggtaat caagttcttc agtcaatgtt tcctgaaact cttccggcat atgatagatc 843661 tcgttttcca gacgatgcag cttcttcaat gtatcaagcg cccgatttgc agtaataatg 843721 gcctgtctga acaggacaag ctttcttgat ttcacataag tcgttttctt aaagtaactt 843781 ctttcttctt tatatagaag atatgtctga tcaagcttga tcattttttc tttcagtttt 843841 tcaatatcct ctttcaaaat cgaatgctct gtcgactgcc gcatggacaa tctgatccac 843901 ttcataattt cttcggtgtt ttcgacggta ttatgaatca gctttgtttc gtacttagga 843961 ggcaaaaaca caaggttgac gataaaggaa gaaagcaccc ctaagatgac tgtgcttgtt 844021 ctgatcagcg cgaacattaa aaagtcgtca ccggcagatt ctaatatcgc aatgactgtt 844081 acaagagcaa ttgaaattgt atgttcaatt ttaagtttca gcatgattgt aatgacaata 844141 actgctgtta acccgatcat aatcgggctg ggtccgaaaa taaggccgaa cactgtggca 844201 atcacagctc cgatgatatt tgcttgaacc tggtcaataa taatgagaaa agagcggtaa 844261 atcgacggct ggatcgcaaa tatcgctgca attccagcga aaatcggcgc gggaagcccg 844321 atccacgaag ccaaataaag ggcaagtgta atcgcaatcc cggttttgaa aatgcgggca 844381 ccaagtttca ttggtttgtg cgtgcattcc tttctatagt aaattgtgtg acatagcaaa 844441 tgggctaatc cttaaaattc ccggttagtt tatttgctaa acaattaagt aatatacagg 844501 gatcgataca aatattcaag ctatttttct agaaaaagac caaaatctta cacgctgttt 844561 gattccataa aaaaacagga gctcaaagct cctgttcaag gtatttgatt ctagtttttt 844621 agatgtttaa atgcatcctc gaccgctgta agcgtgtctt taatatcctg ctctgtatgt 844681 gctgtggtaa taaaccaagc ttcatactta gaaggtgcta aattaattcc gcgttccagc 844741 atcagcttga aaaacgtaga gaatgtttct ccgtcactcc gttcagcctg ctcgtaattt 844801 tccactttct catcagagaa gtataccgtg agcgcacctt ttaaccggtt gaccgtaatg 844861 gtgatgccgt gtgtttctgc gtgcttcaaa atgccttcct caagcatagc gccaaggtga 844921 tcaagctttt catacacgcc tttttctttg agcacttcca gacaagcgat gcctgatagg 844981 atggaagcgg ggttccctgc cattgttcct gcctgataag caggccctag cggagctacc 845041 tgctccatga tttcttgttt gccgccatag gccccaatcg gaagtccgcc gccgataatt 845101 ttcccgagtg ctgttaaatc tggtttcacc tgtaagagat cctgcgcgcc gccatacata 845161 aagcggaaag ccgtaatgac ttcatcgtaa ataacgagag cccctgcatt atgtgttaat 845221 tcatttactt gttctaagaa gccctctttc ggctccacga taccgaagtt gccgacaatc 845281 ggttcaacga gaaccgccgc gatttcactg ccccattttt caagagctgc tttatagcta 845341 tcgatatcat taaatggtac tgtgatcact tcgtttgcaa tgcttttcgg tacaccggct 845401 gagtctggtg tgccgagagt agacgggccg gagcctgcgg cgacaagcac aaggtccgaa 845461 tgcccgtgat agcagcccgc aaatttaatg atttttgtcc ggcctgtata tgcgcgagcc 845521 acgcggatgg tcgtcataac ggcttctgta cccgaattga cgaatcttac tttgtccata 845581 gcgggaatgg cttctttgag catttttgca aatgtaacct cgtgtttcgt tggtgttcca 845641 tacaatacac cgttctctgc tgctttttta atcgcttctg taatatgcgg atgggcatgt 845701 cctgtaataa tcggaccgta cgccgctaaa taatcgatgt atttgttgcc gtccacatcc 845761 caaaaataag cgccgcttgc tttctccatt gcaacaggag aaccgccgcc gactgcttta 845821 tatgatctag acgggctgtt tacaccgccg acaatgtgct gtaatgcctc attgtgaagt 845881 tcaattgatt ttgtatgcaa gaataaaaac ctcctatatc tccatgcgtc ctttctattg 845941 tagcatgctt ccgaacaaga acaatggctt cgggcttcag attcagctga gatggttgta 846001 atctggacaa gaattggata cgcttaataa aaaaacatcc ggaggtaacg taatgactat 846061 agaaatcgga caaaaagcgc ctgatcttga gttaaaaggt gatcatgggg aaacagtaaa 846121 attatcggat tataaaggaa agtacatcgt gctttatttt tatccaaagg acatgacacc 846181 gggatgtaca actgaagcat gcgattttcg ggacagtcac gaaagcttcg ccgaactgga 846241 tgccgtcatt atcggcgtca gcccggacag ccaggaaaaa cacggaaaat ttaaagagaa 846301 gcataacctt ccatttctgc ttcttgttga tgacgagcat aagctggcgg aagcatttga 846361 tgtgtggaag ctgaagaaaa acttcggaaa agagtatatg ggaatcgagc gttccacttt 846421 tttaattgat aaagaaggcc ggctcattaa agaatggaga aaagtaaaag taaaggacca 846481 tgtagccgaa gcgcttcaaa ccctcaaaga tatgtctgaa aagtaaatct ctatgagcct 846541 atgcttactt ttaccctgat atcaattgac aaattatcgt agaaagagtt acactaatta 846601 taaacattac aatgtaagaa ttttttttag aagagaggtg catgacggat ggctgcacat 846661 gaactaaaag aagccttaga aacgttgaag gaaaccggag ttcgcattac tcctcaacgt 846721 catgcgattc tggaatatct cgttaactct atggctcatc caacagcgga cgatatatat 846781 aaagctctgg aagggaaatt tcctaacatg agcgtagcga cggtatataa caatttgcgt 846841 gtgttccggg aatcaggttt ggtaaaagag ctcacatacg gtgatgcttc cagcagattc 846901 gattttgtca catccgatca ctatcacgcg atttgcgaaa actgcggtaa aattgtggac 846961 ttccactacc cgggccttga tgaagtggag cagctcgctg cccacgtcac gggcttcaag 847021 gtaagccacc accgtttaga aatttacggc gtctgccaag agtgttcgaa aaaagaaaat 847081 cattaaaaat aagctgaccg cacgaaacgg tcagcttatt ttatttcgac attttctttt 847141 tattataaga ctcatcaaat tcttttcctt ctaatccctt atctaaagtc agcggctctc 847201 ggcaatgcat gcacatatcg actactccta aaacctttgt ctctttatca cagcctggac 847261 aaatgacgcg aaccgcttta gtcgaaagca ttccgatcca aaagtaaact accgtgctga 847321 gaccgatgga taaaagccca agtatcataa acaaactaga aagcaaaact gactctttga 847381 aaaagatccc gatgtacata atgataaacc caacgaaaac caaacttaac gcaaatgttc 847441 tgattttatt aattttgctg gagtatttcg ccatgtccat ccccctctgt tttaactata 847501 gcacaaaccc gatgggattt tcttcatgtt ttcggttgaa ctggaattta catatggaga 847561 gttactgtga aattgtttat aatagttcaa tgtgtttaga aaaaaggaat ttcgttttaa 847621 ccatagaatt gaatcaaata gagaataaaa aaatttgaac aattgcattg gaggaatagt 847681 gatggaaaat cttctccgtc caatttacca agaaagagca agtcacccca atacattggc 847741 tgtcattatg attgagagaa gaaacaaaac atcttcctta acagataact ttgatgcagc 847801 tttgctggtg attgtaaagg atgctgatga gccagttttt ataaagcatt atgaatttga 847861 tcatcaaaca gcttctttgc atgtggtaac agattctcag attcaagaat ggattttgct 847921 tggaacaaat agaagaatca tagattggat tgtaaatggc agagtcttgt ttgaccgtaa 847981 tgaatacgta gttgaactga ttgacaggct gaatacattt ccgtttgccg aacgtaaact 848041 gaagatcgga ctcgaatacg gcaaattaat cagaaggtat gttgaaggga aagctttttt 848101 tgaagccaat caatttttag atgcctacaa tgccgttgtt catgcgctgc atcatttagc 848161 acgtattgaa gtaatcgaca gaggattcca tcccgaaacc acggtgtgga gccaagtgcg 848221 ccagatggag ccccaagtgt acaaattata ttccgagctg attgaaagtc atgagagcct 848281 ggaaaaaaga cttgaattat tattcttagc aaatgatttt ctcatccatt ccaaagccga 848341 gatcggttcg gcgcatcttt tcgaagtaat gaaagaaaaa gacatttggc aattcggtga 848401 gcttcttcaa catcatgacc taaagcactt tacccaagat cttggcgtta tgcttgatta 848461 cttgacggaa aagggactta tcaacgtctg ccagatagaa acgaaaggac aggctgtcta 848521 tcaccgagga tattctttta aaaaaggtgt tgactctgat tcttgaccgt gttatattat 848581 taaacgtcgc tgatgcgctt ctgagaaaac aagctcacag cggcgggaaa ataaatcaaa 848641 aaaacatttg acaaaagaaa gtcaaaatgt tatattaata aagtcgcttc aacaagaagt 848701 gaaaatgatc tttgaaaact aaacaagaca aaacgtacct gttaattcag tttttaaaaa 848761 atcgcacagc gatgtgcgta gtcagtcaaa ctagggcctg cacgacgcag gtcacacagg 848821 tgtcgccgca ggatgcggtg aacttaacct gtgatccatt tatcggagag tttgatcctg 848881 gctcaggacg aacgctggcg gcgtgcctaa tacatgcaag tcgagcggac agatgggagc 848941 ttgctccctg atgttagcgg cggacgggtg agtaacacgt gggtaacctg cctgtaagac 849001 tgggataact ccgggaaacc ggggctaata ccggatggtt gtttgaaccg catggttcaa 849061 acataaaagg tggcttcggc taccacttac agatggaccc gcggcgcatt agctagttgg 849121 tgaggtaacg gctcaccaag gcaacgatgc gtagccgacc tgagagggtg atcggccaca 849181 ctgggactga gacacggccc agactcctac gggaggcagc agtagggaat cttccgcaat 849241 ggacgaaagt ctgacggagc aacgccgcgt gagtgatgaa ggttttcgga tcgtaaagct 849301 ctgttgttag ggaagaacaa gtaccgttcg aatagggcgg taccttgacg gtacctaacc 849361 agaaagccac ggctaactac gtgccagcag ccgcggtaat acgtaggtgg caagcgttgt 849421 ccggaattat tgggcgtaaa gggctcgcag gcggtttctt aagtctgatg tgaaagcccc 849481 cggctcaacc ggggagggtc attggaaact ggggaacttg agtgcagaag aggagagtgg 849541 aattccacgt gtagcggtga aatgcgtaga gatgtggagg aacaccagtg gcgaaggcga 849601 ctctctggtc tgtaactgac gctgaggagc gaaagcgtgg ggagcgaaca ggattagata 849661 ccctggtagt ccacgccgta aacgatgagt gctaagtgtt agggggtttc cgccccttag 849721 tgctgcagct aacgcattaa gcactccgcc tggggagtac ggtcgcaaga ctgaaactca 849781 aaggaattga cgggggcccg cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg 849841 aagaacctta ccaggtcttg acatcctctg acaatcctag agataggacg tccccttcgg 849901 gggcagagtg acaggtggtg catggttgtc gtcagctcgt gtcgtgagat gttgggttaa 849961 gtcccgcaac gagcgcaacc cttgatctta gttgccagca ttcagttggg cactctaagg 850021 tgactgccgg tgacaaaccg gaggaaggtg gggatgacgt caaatcatca tgccccttat 850081 gacctgggct acacacgtgc tacaatggac agaacaaagg gcagcgaaac cgcgaggtta 850141 agccaatccc acaaatctgt tctcagttcg gatcgcagtc tgcaactcga ctgcgtgaag 850201 ctggaatcgc tagtaatcgc ggatcagcat gccgcggtga atacgttccc gggccttgta 850261 cacaccgccc gtcacaccac gagagtttgt aacacccgaa gtcggtgagg taacctttta 850321 ggagccagcc gccgaaggtg ggacagatga ttggggtgaa gtcgtaacaa ggtagccgta 850381 tcggaaggtg cggctggatc acctcctttc taaggatatt atacggaata taagaccttg 850441 ggtcttataa acagaacgtt ccctgtcttg tttagttttg aaggatcatt ccttcgaaac 850501 gtgttctttg aaaactagat aacagtagac atcacattca attagtaata caagatatca 850561 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 850621 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 850681 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 850741 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 850801 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggattagcc caaaccaaga 850861 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaagaac gaggtagatg 850921 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 850981 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 851041 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 851101 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 851161 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatccc 851221 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 851281 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 851341 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 851401 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 851461 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 851521 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 851581 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 851641 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 851701 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 851761 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 851821 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 851881 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 851941 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 852001 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 852061 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 852121 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 852181 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 852241 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 852301 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 852361 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 852421 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 852481 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 852541 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 852601 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 852661 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 852721 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 852781 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 852841 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 852901 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 852961 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 853021 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 853081 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 853141 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 853201 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 853261 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 853321 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 853381 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 853441 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgagggct 853501 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaat aagtttttca 853561 aaaaaacact tgattttctc aagaatacat agtataatgt taaatgtcac tgaaattgtc 853621 tggtgatgat ggcgaagagg tcacacccgt tcccatgccg aacacggaag ttaagctctt 853681 cagcgccgat ggtagtcggg ggtttccccc tgtgagagta ggacatcgcc aggcagactt 853741 cattccgcag tagctcagtg gtagagctat cggctgttaa ccgatcggtc gtaggttcga 853801 atcctacctg cggagccatt attggagagc tgtccgagtg gtcgaaggag cacgattgga 853861 aatcgtgtag gcggtcaact ccgtctcaag ggttcgaatc ccttgctctc cgccactgat 853921 acttatacat aattacaatt gaaagtctgg gcccgttggt caagcggtta agacaccgcc 853981 ctttcacggc ggtaacacgg gttcgaatcc cgtacgggtc attatatgat ggaggattag 854041 ctcagctggg agagcatctg ccttacaagc agagggtcgg cggttcgagc ccgtcatcct 854101 ccaccattat atcatcgcgg ggtggagcag ttcggtagct cgtcgggctc ataacccgaa 854161 ggtcgcaggt tcaaatcctg cccccgcaac caaattttaa aatggtccgg tagttcagtt 854221 ggttagaatg cctgcctgtc acgcaggagg tcgcgggttc gagtcccgtc cggaccgcca 854281 tttgaatact taggctcggt agctcagttg gtagagcaac ggactgaaaa tccgtgtgtc 854341 ggcggttcga ttccgtcccg agccaccacc tatgccggtg tagctcaatt ggtagagcaa 854401 ctgacttgta atcagtaggt tgggggttca agtcctcttg ccggcactgt tttttcaaaa 854461 tttaatgtgg aggggtagcg aagtggctaa acgcggcgga ctgtaaatcc gctccctcag 854521 ggttcggcag ttcgaatctg cccccctcca ccatttatag gggcatagtt taacggtaga 854581 acagaggtct ccaaaacctc cggtgtgggt tcgattccta ctgcccctgc caaatttatg 854641 acatcttgag attatggcgg ttgtggcgaa gtggttaacg caccagattg tggctctggc 854701 actcgtgggt tcgattccca tcaatcgccc catattatca ttgggctata gccaagcggt 854761 aaggcaacgg actttgactc cgtcatgcgt tggttcgaat ccagctagcc cagtctcact 854821 ttttatatca actgcatata atgtattaag tccattaaaa atgcggaagt agttcagtgg 854881 tagaacacca ccttgccaag gtgggggtcg cgggttcgaa tcccgtcttc cgctccaatt 854941 acggcggcat agccaagtgg taaggcagag gtctgcaaaa cctttatccc cggttcgaat 855001 ccgggtgtcg ccttcttatt gccggggtgg tggaattggc agacacacag gacttaaaat 855061 cctgcggtag gtgactaccg tgccggttca agtccggccc tcggcaccaa ttttacttac 855121 atggtaagtt gaattggtgt ttgtgtttta tcattataac taatcatatt aatgatctac 855181 ataagtagat cattttttta atgctttgat ttatcataac aagttaagtt ccgaggccta 855241 ttataaagcg gctgtatagc tagtctttca acacttttat tttatatttc cataaaaact 855301 tttttgaaat acgttgacac tttatgagat ccatgatata tttatattcg tcggttagat 855361 acgacgtaaa acttgccggt gtggcggaat tggcagacgc gcacgactca aaatcgtgtt 855421 ccttctggag tgtcggttcg accccgacca ccggtatact gaaaaacccg tttcttaaca 855481 gaaacgggtt tttatttttt attaaagaaa aggagcctcg gctccttttt atacttactc 855541 agcgtattgg tctaggatct cttctagcac ctcttctagc tcttctgtat cttcaagctc 855601 tgattggctg aaacggacgc gtacaagctg ttctccgtca ttatacatct cttccaacca 855661 ccctcggagt cctcttgctc tgcggtcgac ttcgaaaatg atttccaaac cgtcttcgtc 855721 taaaaggaaa atgagctcta attcatcaag catctgacga taatatccgg aagtcggaac 855781 gaattcgaat tcttgaacga acggaagacg acgctggaag tagggcgctt gttcgcagtc 855841 tgcttcgtta agacggaagc ccaggttttc gattgcttca agcacatttt caatccaagg 855901 gtgcgcttca acgaaaatgc ggtcatgatc ggatttatcg ataccgcctt gaatgtcaag 855961 gtctgtcacc acggcaacct ctactttccc tacagtgatc ggcgtatcta gaggcagagt 856021 gaatgtgaac ggaaattgat gctcttcacc aggctgtatg gtaaatgaac cagtgacccg 856081 gaaagaatga attgtagcgt atttccggtg ctcttcatcg tcttttacaa tgacataccg 856141 tgtgctaagc tgtaaatcga tataacggat gtcctgagcg atttttccgc ctttgacatg 856201 taccgttccc tgtacttctt ctcctggaaa atatgcgtct ttttctaaaa ttgtatctac 856261 ttttgcagct ccaattccgg cacttgccgc aagcttctta aaaaatgaca tgttagatct 856321 tccccttttt cttttttctc aacagatata cgtaagaagg aggaaaaaag attcgtttga 856381 ttcatacttt tttcctatta ttcgtctcgg cctagggaca gactaagaat aatattgaaa 856441 ataaaggagt cgatggaagt gaataaagaa agtttggttg cagatgaatt acacagaatg 856501 tttttggctg gtgagctgca aatcacagta gaggaggata taaacaatat ttccgaaagg 856561 ctgagaaacg gcgatctcag tttagaccga ttaagcggtg aagacgtgtt tataaaagaa 856621 acggtaaatg aggctttaag aagagtggag caataaaaaa gagacggcat ctcatctttg 856681 agatcccgtc tctttttgtg gtctttgctg taagataaaa gcgaatcgat ttggaattgc 856741 tcacccgagc cacccctttt ctaacagaag atctgacagt tcatcatgga gataaacagc 856801 tgtatctaat tgatcatgca atgctcttct gatgtgggga ttttcggttg ctgttgttgc 856861 gacagtgtat ttgttaatgc tggtttttat tgttgttaac aaatcaagaa tatctttggg 856921 acaaagactt tgttcaatgg gaaaccacct cctttgtttt tttagcagct cctgataaga 856981 aagtatttga ctttgtttct tgcttctata caaaatgcta taataagcaa caaattttgt 857041 tggggggtgt gatgatgaag cagattattg cgatgggggg cgggggtttt tcgatggagc 857101 cggataattt gtccctcgat caatatatcc tcaatcaatc aaaacgagag cagcctcgta 857161 tttgtttttt gccgacggcg agcggagatt cccaaaacta tattcagcgg ttttatcatg 857221 catttcaaac attggattgc gtgccgtctc atttatcttt gtttaagcca ccatcatcag 857281 atttagtttc ttttgttatg gaaatggacg tgatttatgt tggcggggga aatacgcgga 857341 atttacttgt gttatggaaa gagtgggggc tggaccatat tctcagggaa gcatggaaga 857401 acggtgtggt tgtagctgga ataagtgccg gtgcgatctg ctggtttgaa gaaggggtga 857461 cagattcagc cggaccgctg acaagtttga aaagtttagg ttttttgcaa gggagctttt 857521 gtccccatta tgacggggaa aaggatcgga gaccggcata ccaccagctg atatctaaca 857581 agttcttatg cagtggctat gcagcggatg atggggctgc tctccatttc ataaatgatc 857641 agctgtttca gactgtgagt tcaaggtcgg gtgcaaaggc atatcgggtg atgatggctg 857701 aacatgaaat agctgaaatc ccgttgccgg tcaaatattt agggtgaaat tggctgaata 857761 ttatctatat tcctcttttt ttcagattga ttttatgata agatgagtgc gaaatcaata 857821 gttactgggg gtgcccgctt tcgggctgag agagaaggca agcttcttaa ccctttggac 857881 ctgatctggt tcgtaccagc gtggggaagt agaggaattg tttttgttat tgtcttgctg 857941 ggcaataata tgtttctttc tgactgtaac cgggttcatt tatatgaatc cggttttttg 858001 tgctggttat gggcttgatt ttgtcctttc aaacgtagaa aggggaagga aaagtaatgc 858061 aaaacaattc agtgcagcaa gccaacattt ccattatgtc aagtttttca ggcagcaaga 858121 aggtatacgt ggagggttct tcttcggaca tccaagtgcc gatgagggag attgcattga 858181 gtccgacgac gggatcgttc ggcgaagagg aaaacgcgcc tgtgcgtgtc tatgatacaa 858241 gcggaccgta tacggaccct gaagtaacca ttaatattca agaaggatta aagccgctcc 858301 gccaaaaatg gatcacagag cgcggtgacg tggaagagta tgaaggtcgg gctataaaac 858361 cagaagataa cggttataaa aaagcaaaac caaacgtaag ctatccagga ttaaagcgga 858421 aaccgctgag ggcgaaggca ggtcaaaatg tcacacaaat gcactatgca aaaaagggga 858481 tcattacacc tgagatggaa tttatcgcca ttcgtgagca tgtgtctcct gaattcgtca 858541 gagacgaggt agccagcggc cgggcgatta ttccttcaaa cattaatcac cctgaaagtg 858601 agccaatgat tatcggccgg aattttcatg tgaagattaa tgcaaatatc gggaattcag 858661 cggttacgtc atccattgaa gaagaagtgg aaaaaatgac gtgggccatc cgctggggag 858721 cggatacgat gatggatctc tctaccggaa aagatattca tacgacgcgt gaatggatta 858781 tccgcaattg ccccgtgcct gtgggaactg ttccgattta tcaggcgctt gaaaaagtaa 858841 acggcgtagc tgaggattta acgtgggaga tttatcgtga tacgctaatc gagcaggcag 858901 agcagggagt ggattatttt acgattcacg cgggtgtttt gcttaggtat gtaccgctga 858961 ctgccaaacg gacaactggt atcgtgtcac gcgggggagc gattatggcg cagtggtgtc 859021 tggctcatca tcaagaaagc tttttataca cacattttga agaaatatgt gagattatga 859081 aaatgtatga tattgctttc tctcttgggg atggtttgcg tcccggatca attgctgatg 859141 ccaatgacga agcgcagttt gctgaattag agacgcttgg agagctgacg caaattgcct 859201 ggaagcatga tgttcaggtg atgattgagg gtcctggaca tgttccgatg cataaaatca 859261 aagagaacgt cgataaacaa atggacattt gtaaagaagc gcctttttac acattggggc 859321 cgttgacaac ggatattgct ccgggatatg accatattac ttcagcgatc ggagcggcga 859381 tgatcggttg gtacgggaca gcaatgcttt gttatgtaac gccgaaggag catttggggc 859441 tgccaaaccg tgatgatgtt cgtgaaggag tcattacata taagatcgct gcgcacgctg 859501 cggaccttgc aaaagggcat cccggagcgc aaatccggga tgatgcgtta tcgaaagccc 859561 gttttgaatt ccgctggcgg gatcagttta atttatctct tgatccggag agagcccttg 859621 aataccatga tgaaaccctg cctgctgaag gagcaaaaac cgctcacttt tgttccatgt 859681 gcggtccgaa attttgcagc atgagaattt cacaggatat tcgggattat gcgaagaaaa 859741 acgatctcag tgaagcagaa gccataaata aaggattaaa agaaaaagca aaagagtttg 859801 tcgatacggg aagcaattta tatcaataaa aaaaatgaag atggagaatg ctccatcttc 859861 atttttttag aaaaacagag agcgtcgaag cggaggaata ctctgttcaa agcggaaaac 859921 attttctgga tcatatgtcg ttttgacacg gcggagtcgt tcaacgtttt cgccgtaata 859981 tgttcttggc cagtttctga tttcgatatc tggccaattt acgtagtctc ccatcgtttc 860041 tttcgaaagg gacgttctca gcccctcaat ccagcggaca ttttgtcttt tttctccagg 860101 ggatgtccag tttgttaagt attcctgggc gatgattgcg tcacgataat aaaatgccgt 860161 ttggtcggga gcgacccgtc cggctgcccc gccgagtgct tgctgccaga cactggcgtt 860221 ttgattcgga gcgtgctcta aaaagtgttt tattgttgag atcgcacgtt ctgataatgg 860281 cttttcaatg aaagagccgg agcgtttcat tttttgaggc tgattgcctc ccgggctgtt 860341 aaaaaaggtt accgcttcaa tgaatggcgt tgtttttacc attccgcttg tcggacttcc 860401 tgctttcaat aaaggcttta acagtttttt taactctgtt tttggcccga caaattggcc 860461 gagggcttct atgcggttta cttctttagg ccaaaactct attgatgatg taagccggtc 860521 atctgtatac ggggcccagt tctgccacgt gttatatact tcctcaaaat catcccatcc 860581 ccatgtaata gaaaaaatcg acacttgaga gatgggcact gctttaaatg tcatggaggt 860641 gactatgccg aaattgcctc ctccgcctcc ctgagacgcc caaaataagt ctggatgatt 860701 tgaacagctg actgtaatca gatcagcgcc ctctttttcg tctgctacga tcatctcaag 860761 ctgcacgagg ctgtcgcaag taagaccggc agcccttgtt aaaagtccaa ttccccctcc 860821 gagagttaaa cctgtgagcc ctacattagc aatggtgcct gcgggaagcg tcaggccgta 860881 ttgccagagt gtccgataga cttctcccaa ttcagccccc gcttcaatat aggccagctt 860941 tttatcctga ttcacagtta tttttttcat ctcgcttaaa tcaataacaa gaccgttatt 861001 taaaagggaa aagttctcat agctgtgtct gccgcctcta atacggaaag gcacacggtt 861061 ttcacgcgcc catttcagcg cattgagtgc atcctgtttg ttttggcaaa acacaatgat 861121 gtcaggatac ctttctaagc ttaggttaat attggttctt gcttcgttat agtccggatc 861181 atcccgtgtc acgatacgtc cggtcaattt tgtcttttcc acactcccac atctctttct 861241 ctcgtattct agtttctcta gcttatgcgt caggggaaaa gagtgtataa ggaaaaagcg 861301 gggatgcaat ctgatacagt gtcaacaccc tcaaaaaata gttgacaggt cggtattgta 861361 tgaattaaca tggtcagtac aaatttttca aatttatcgc gctgatcgga acaccgaagg 861421 ctcttatcgt ttagataagg gccttttttg tatgaaaaag gggggattat tgatgggagt 861481 caaaaaagaa aaggggagaa aacgattcag gaagcgaaaa acctacggga atcagatttt 861541 gccgcttgag ctgctgattg aaaaaaacaa acgagagatt ataaacagcg cggaactcat 861601 ggaagaaatt tatatgaaga ttgatgagaa gcatacgcaa tgtgtaacta aatataaaaa 861661 aacccgctga ctacaacggg tttttgcatt tctccattaa gaatcttttt taatcggcaa 861721 tccaaggcct tctgccacgc gttttccgta ttcaggatcc gctttgtaga agtgctcgat 861781 ttggcgcagc ttgatttctt ctttttctac cggcttcatg gcattaacga tattttcaac 861841 aaggcgggta cgttcatctt cactcattaa acgatacaga tcgccggctt gagtgtagtg 861901 atcgtagtga tcgtagctta cgctgtcagc gataccttgt accggatatg ctgcttgctt 861961 atcctcaggt gactcttttg gaccgccgaa gctgttaggc tcgtaataca cagatccgcc 862021 gccgttatca tcaaaacgca tttgcccatc acgctgataa ttgtttactt tgttgcgtgc 862081 gcggttgatt ggcagcgctt gatggtttgc accgacacgg tagcggtgtg catcatgata 862141 agcaaaaagt cgaccttgaa gcattttatc cggtgaaaca tcaataccag gcacgagggt 862201 tccaggtgaa aatgtcgctt gttctacctc tgcaaagtag ttttccggat ttctgtctag 862261 aaccatgcgt ccgacctcga ttaacgggta gtctttttga gaccaaactt ttgtgacatc 862321 aaacggatcg aaacggtacg tatttgcatc ttctaaaggc atgatttgca catatagttt 862381 ccatgcagga taatcaccgt tttcgattgc gttgaaaagg tcttctgtat ggtaatcagg 862441 gttttcaccg gcaatttttg ctgccgtatt gacatcaagg tttttcacgc cttgttctgt 862501 tttaaagtga tatttaatcc atacgccttc gccttcggca tttgtccatt tgaatgtatg 862561 gcttccgaag ccgtgcatgt ggcgaagtgt cgcaggaatt ccgcggtcag acatcaggat 862621 tgtcacttgg tgcagtgact ctggtgaaag tgaccagaaa tcccatacag ccgtagggtt 862681 tttcaggtgt gtttttggat ctcttttttg tgtatggatg aaatcaggga acttaatcgc 862741 atcgcggata aagaatacag gcgtattgtt gccgacgatg tcgtagtttc cttcttcagt 862801 ataaaattta acagcaaatc cgcgcgggtc gcgaactgtg tcagcagagc caagttcacc 862861 ggcaactgtt gagaaacgga tgaacaacgg tgtgcgtttg ccgacttcag aaaggaaagc 862921 ggctttcgtg tattttgtta cgtcgtttgt cacttcaaaa tatccgtgtg cgcctgctcc 862981 tttggcgtga acaacacgtt caggaacacg ttctcggttg aaatgggcca atttttcgag 863041 taaatgtaca tcttgaatta aagttggtcc gcgagaaccg gcagtcattg agttttgatt 863101 atctccaacc ggagcgcccc agctagttgt cagtttattt gaactcatgt tatcacctct 863161 tggaatttat aagaacataa tatcatctct aagtaaaaag tcaatattat tttataatta 863221 ttataaaata gttatctcta ttaatcgata tatagtatcg aaattgttga aaaaccttgt 863281 tgtaacagct ttttatgaca cttaataatt tttggagaaa taatttttcc ttctctattt 863341 gcgaaacaag cagagtaagt gataaacaag gatatcaaaa atcgtattta aaaaagagtt 863401 gacatatcgg aataatttga attaacatgt tattcaaaca aaaaaacaat tgggcagctg 863461 atcggaccgc cgaaggctct catctctaca agaacagaga tgggggcctt tttgtttttt 863521 ttgaaggcgg ggttggcaga aagagaggga taaaagtggc tgtgaccatc agcatcaaag 863581 aaaaggcatt tgttcaagaa ggccgcaaaa acacggtctt agaaaacata gaattatcaa 863641 tcgcaccagg cgaatttcta acgcttatcg gaccgagcgg gtgcggaaaa agcaccctgt 863701 taaagattat tgcagggctt gattctgaat atgacgggag tgtggaaatt aacggccgca 863761 gcgtaacagc tccgggtatt cagcaaggat ttatttttca ggaacaccgc ctctttcctt 863821 ggctgactgt tgagcagaat attgcagccg acttgaattt gaaggaccca aaagtcaaac 863881 aaaaggtgga tgaactgatc gagattgtca gattgaaagg atcggaaaaa gcatatccgc 863941 gcgagctgtc aggcggcatg tcacaaagag tagccatcgc ccgggccctg ctgcgggagc 864001 ctgaggtgct gcttttagat gaaccgtttg gtgcactcga cgcttttaca agaaaacacc 864061 tgcaggacgt gctgctggat atatggagga agaaaaaaac aacgatgatt ctcgtgactc 864121 atgatataga tgaatctgtt tatttaggaa atgagcttgc gatccttaag gccaaaccgg 864181 ggaaaatcca taagctgatg cccattcacc tggcgtatcc gcgaaaccgg acgactccgg 864241 atttccaagc gatcagacag agagtgctgt cggaattcga gaaaacagaa gatttggagt 864301 acgcagaagg atcagggata tagaaagggc ggaagcggaa atgaaaaaag gactcattgt 864361 attggttgcc gttatttttc tgctcgcagg ctgtggagca aatggagcca gcggtgacca 864421 caaacaattg aaggaaattc gtattggtat tcagcaaagc ttaagccccc ttttgattgc 864481 aaaagaaaaa ggctggttcg aagatgcatt tgaaaaagaa ggcatcaaag tgaaatgggt 864541 ggagtttcaa agcggtccgc cccaatttga aggccttgcg gcagacaaac ttgatttttc 864601 tcaagtcggt aattcgcctg tgatcgctgg acaggcggca ggcattgact ttaaagaaat 864661 cggtttgtct caggacggct tgaaagcaaa cggcatcctt gtcaatcaaa acagcggcat 864721 tcaagacgtt aagggcttaa aggggaagaa aattgcagtc gccaaaggca gcagcgggtt 864781 tgattttttg tataaagcgc ttgatcaagt ggggttgtca gctaacgatg tgacaattat 864841 tcagcttcag cctgatgaag cagcttccgc atttgaaaac ggatctgttg atgcctggtc 864901 catttgggag ccgtacttgt ccttagaaac aatgaaacac ggagcaaaaa tccttgtgaa 864961 cggagaaagc acagatttat attcaccggg ttttacttta gtaagaacaa agttttcaga 865021 agagcatcca gacgaagtgg tccgttttct gaaggtgttt aataaagccg ttgtatggca 865081 aaaggaacat ctggatgaag cagcggactt atattctgac attaaagatc tcgataaaaa 865141 ggtcgtcgaa aatgtgctga aaaatactga gccacttaat gagatcatca gtgacgacat 865201 tgtgaaagca cagcaggaaa cagcagattt tcaatttcga acaaaggcga tagataagaa 865261 gattgatgtg aaggatgttg tcgataacac ttttatcaaa aaagcattag aggagcattc 865321 ctcaggaggt gatcaatgat gaaagcagag gctgcgggct cgctgcccaa aacgaatgcg 865381 gaagcggtgc gaaaaaagcc cggaaggaag agatacggct ggatgaaggg gcttttactg 865441 cccgctgtca tcattgccat ctggcaggtc atcggcgggc tgggggttgt gtccgctaca 865501 gtgctgccta cacctgttac gattgttctg acctttaagg agcttatttt gtccggcgaa 865561 ctgttcggcc atctgcaaat cagcatttat cgggcggcac ttggtttttt gcttggcgcg 865621 gggcttggat tgatgatcgg gattttggcc ggattttcca aacggacgga gctgtatctt 865681 gatccgtcgt tgcaaatgct tagaaccgta cctcatctgg ccgtcacgcc gctgtttatt 865741 ttatggttcg gatttgacga agtatctaaa attttgctga ttgcgctcgg tgccttcttt 865801 cctgtctata tcaatacgtt taacggcatc cgcggggttg acgcgaagct gtttgaagtc 865861 gcccgggtgc ttgaatttaa atggcatcag cagatatcca aagtgatatt gccggcagcc 865921 ctgcccaata tattgctagg cattcgctta tcgctcggca ttgcatggct cgggctcgtt 865981 gtggcagagc tgatgggctc aagctcggga gtcggctata tgatcatgga tgcgagacag 866041 ttttcacaaa cgaataaagt ctttgcaggg attatcattt ttgcagtggt tggaaagctg 866101 acggattcct tcgtcaggct gcttgaacga aagctgttaa agtggagaaa cagctacgaa 866161 ggataaaaga tataaagggg agatgaatat ggaaattctt tggtttatac cgactcatgg 866221 agacgcgaga tatttaggat ctgaaagtga tggacggact gcggatcatc tttactttaa 866281 acaagtcgcg caggcggcag acaggctggg atatacagga gttcttctgc caacgggaag 866341 atcgtgcgag gacccgtggc ttacagcgtc ggcactggca ggagaaacaa aggacttaaa 866401 gtttttagtc gcggtaagac ctggtttaat gcagccttct ctggcagcca gaatgacatc 866461 caccctagac cgcatttcag acggccggct gctgatcaac gttgtggcag ggggcgatcc 866521 gtatgagctg gcaggcgatg gcctgtttat cagccatgat gagcgctacg aggcaacaga 866581 cgaattttta accgtttggc ggagactttt gcagggagaa acggtttcct atgaaggaaa 866641 gcatataaaa gtggaaaaca gcaatctgct tttcccgccg cagcaagagc cgcatccgcc 866701 catctatttc ggtggttcgt cacaggctgg aattgaagct gccgcaaagc atacagacgt 866761 gtacttgaca tggggtgagc cgcctgaaca agtaaaagaa aagatagaaa gagtcaaaaa 866821 gcaagcggca aaagaaggga gatccgttcg atttggcatt aggctgcatg tcattgcccg 866881 tgaaactgaa caagaggcat gggaagcggc agagcgcttg atcagccact tggatgatga 866941 caccattgcc aaagcgcagg cagctttgag ccgttacgac tcttcaggcc agcagcggat 867001 ggccgtcctt catcaaggcg atcggacgaa gcttgaaatc agcccgaatc tgtgggcggg 867061 gatcggcctg gtcagaggag gggcaggaac agctcttgtc ggtgatccgc agacgattgc 867121 cgaccggata gcggagtacc aggcactcgg catagaatcg tttatattct ccggctatcc 867181 gcatttagaa gaagcgtatt attttgcaga gcttgtattt ccgcttttgc cgtttgaaaa 867241 tgatcggacg agaaagcttc agaacaaaag gggagaagcg gtaggaaaca cttattttgt 867301 caaagagaaa aatgcatgag tttaactaaa atacagcccc ccgaacatgg tatgatattc 867361 aaaaaaaggg ggcttttttt ctgaaaacat tgagaagcgc ggcagtcatt tgcctcatag 867421 ctatgctgtc agcatgcgga cattcaaaac agatggaaat caaagcggcg gacatatcag 867481 atcttgaaaa aaacagaatg gatgtcgcag cttcacaggc attcactgcc gaagccgtca 867541 atatcggtga aggtatttct tcagctgaca tgtacatcga acattatcaa aagggaaagc 867601 ttgttgagag gtttggaccg gttcgtgcag attattcaga ggaaaaaact gataccatac 867661 aatttgttta ttttgagaat gaagaggggg aaggaaagaa taaacatacc accattcatt 867721 ttggcattgt ggataaacag ggaactatag cggctgattc atcggtgaaa cgcgacgata 867781 gcacaacaca ggaaatgact cagaatattt catcgccgga accgattact ttcgagaagc 867841 ctgctttgat cggcagcagt attagaggga ctgacgagac aatgcacacc tctgaacata 867901 aaaaagagct cattaagcat caagatgcgt tactgtatta tgtggaattg catcattaga 867961 atgggcggct tcaggccgtc tgttttacaa agcggtatgc ttgctttttt gaatggtgaa 868021 tgatacattt taaatcgtaa caatttcgat ttaaagggag gctatgtgac ttggctaaaa 868081 aatcaaaagt ggcaaaagag ttaaaacgcc aacagcttgt tgagcaatac gctggtatta 868141 gacgcgagtt gaaggaaaaa ggagattacg aggcactcag caagctgcca agagattcag 868201 caccgggaag gcttcacaac cgctgcatgg taacggggcg cccgagagca tatatgagga 868261 agtttaaaat gtccagaatc gctttcaggg agctggccca taaaggccag attcccggtg 868321 tgaaaaaagc aagctggtaa gaaaaaactc cggccgatta cagcgcgccg gagttttttt 868381 cgtttttctt gaaagagatg acgtaggaaa ggtgctggat gatcatgatg ataaacacaa 868441 taataatagg gaaaaacgga atgcgcgatt gaaatagcgg ataaaaaatg agaagaaccg 868501 ctgcggcagg cagcgagaag tagacagcga tatatgacgc gcgacatgct tttgccgtca 868561 tcatctgctc tctttcatcc tgctcttcaa actcatcagg cagaagtagc tgctttctgg 868621 cagggcggct ttttttctgt aagtacaaat aaaccgcaga cgccgcaaca aacagaataa 868681 agggagtgag gtttaaatca aataccatcc cgccgctctt tgtgccgaaa aaagatgcta 868741 tgccttctga ggcttcaaag tatgaaatca gcgcccagca tgcaaggcca aataaaacaa 868801 ggtgaaaagc tgcttttgtt ttcatgctca tcttagtttt cctcctctaa ccaaaagaca 868861 tcctccattt tcatggagaa ggctttgcag attttcagtg ctaacagcag tgagggaaca 868921 taatcgcctt tttcaatcgc tgccacagtc tgtcttgtga cgccgaccgt ttctccgagt 868981 ttttcctgag aatagccgaa gcgtgccctc agctctttta ctttattttt catcatgacg 869041 tctgtcccct tcacaatctc gattgattat attgtatagt atacttaaca ttatgtaaat 869101 ggaacttaac aactttacaa aaagataact ttttttcgac aaaattttta tattcccttg 869161 acgaaaaata aataaacatg taatataaaa aaagtcagag cggtactgtt gctgacaatc 869221 acaaatgcgg gtgtagttta gtggtaaaac ctcagccttc caagctgatg tcgtgagttc 869281 gattctcatc acccgctcca tacatacgtt attaacgcag tgtttcgttt ctcagataaa 869341 cgaagtattg cgttttttta tgtgaaaaag aacacggtat tcgtgttctt ttacgtaagc 869401 caatgtactg tatgggtgcc gccgtgaatt tgttcaaaca ttttcgttaa tgatgataag 869461 aggttaacag cgctgctttt ctcaatcgat ggcgggaaaa aaatgatttg cagcatattc 869521 ttagtctcgt ttgaaacggg atagtggttg acgctgtttt tgaaatcgcc aaaaatgccg 869581 ttttcatcag agaaaagcag tatgttttct ttttctccca atgagatccg gaccggctca 869641 tgaagctttc cggcatcata aatcataata ggcagagaat attttaatgc gaaaaaatcg 869701 attgtgtcat gggccgagtc tttactttcc atgaattgtt ccttggatat cgggaccagc 869761 atgtcctcca ttggggttgt ttctccctca aatgaagggt taagctgttt aaagagtttc 869821 tgccattcct tgacgaagga ttcatcggat ataccgccgt ccgcatagtc gaaaaacaag 869881 gattcttgaa acaggcggag tctgcctttc agcatttgcg gtgaggagcc gacttcgata 869941 ttctcataaa tgacagcagc tgcatgtaag ccggccgcac gttcagtaat aacagaatca 870001 agtttgatat tcactagcat tcactccagt tacgtgatat caacctatta taaacgctgt 870061 gtcgttttat cacaaagaaa ggaggctgtg caaaacatga acgtttatca gctcaaagaa 870121 gaattaattg aatacgcgaa aagcattggc gtagacaaga ttggttttac gaccgctgat 870181 acttttgaca gtttaaaaga ccgtttgatt cttcaagaat cactcggcta tctctccggc 870241 tttgaagagc cagatatcga aaaaagggtg acgccgaagc ttcttttgcc gaaagcgaaa 870301 tcaatagtgg caattgctct cgcatatcct tccagaatga aggatgcgcc gagaagcacg 870361 agaactgagc gcaggggcat tttttgcaga gcttcctggg gaaaagacta tcatgatgtg 870421 ctgagggaaa agcttgatct gctggaggat tttctaaaaa gcaagcatga ggatatcaga 870481 acgaagtcaa tggttgatac aggtgaattg tctgatcgcg ccgttgcgga acgtgccgga 870541 atcggattca gtgcgaaaaa ctgtatgatc acaacacccg agtatggctc ttatgtgtat 870601 ttggcggaaa tgatcacaaa tatccctttt gagcctgatg tgccgattga agatatgtgc 870661 gggtcctgca cgaaatgctt ggacgcctgc ccaacgggag cactggttaa tcccgggcag 870721 cttaatgcgc agcgctgcat ctcttttctg acccagacaa aaggattttt gcctgatgaa 870781 ttccggacaa aaatcggaaa ccgcctgtac gggtgcgata cgtgccaaac ggtatgccct 870841 ctcaataaag ggaaggattt tcatcttcat ccggaaatgg agcctgatcc tgagattgcc 870901 aaaccgttat tgaagccgct tttggccatc agcaatcggg aatttaagga gaaattcggg 870961 catgtctcag gttcttggcg cggaaaaaaa ccgattcagc gaaacgccat tctcgcgctt 871021 gcccatttta aggatgcttc cgcactgcct gaattgacgg aactgatgca caaggatccg 871081 cgtcctgtca tcagggggac agccgcatgg gcaatcggaa aaatcggaga ccccgcctac 871141 gcggaagagc ttgaaaaagc gctggaaaaa gagaaggatg aagaggcaaa gctggaaatt 871201 gaaaaaggaa ttgagttgct aaaagcttca ggcatgacta aacaaggcct gtcctgacat 871261 acgtatagag cagaaggaaa aaacacttga gatcatccaa gtgttttttc tctataaaaa 871321 agtatggcgg gtggggtgag cttgaagtac attttagaac aattagcgga ggagcggctg 871381 ggctttctgg ttaacgggca tgctatgaga caggagtctc aagtcggaga ccttaaagtc 871441 atggagcgta agaaaaagct tctggaaaaa cgtaaagttg acatcataaa agcgaaagca 871501 aaggccgtga ttaatcatgt gcgggttgag gatgacggaa cgacctgcct ttcgtatacc 871561 atccattacg aatacgtgtg taaggaacaa gatgacagct tgtatataga agagcacata 871621 gaggagcgaa tggctttcct gtatgatcac attttgatta gtgatcagga aattgcgaaa 871681 aagccggctg gatttcatga agggaccagt attattgact attctgaagc tgaagaggaa 871741 agagaagcgt ttggcagggc ttttcaatac gatcgtctcg gcgctgtcca atatgccgag 871801 aaattttgga acaagcgcaa tcctgcttat aaaaatttca gcgataactg tacaaatttt 871861 atttctcagt gtcttcatgc aggaggcgcg ccgatgcgcg gtcatccgaa caggggatca 871921 ggctggtgga tgaaacaaag ctcatggagc tacagctgga cggtggctca ctctatgaaa 871981 atgtatttgt cgaattcaaa ggccggactg cgtgcggtgc gggtgaaatc agcggaagaa 872041 ctgatgccgg gcgatgtgat ttgctatgac ttcgaaggag acggccggtt taatcataca 872101 acgattgtcg tggcaaagga caaaggcaat atgccgcttg tcaacgccca gacttatgac 872161 agcaggatga ggtattggtc atatgaggat tctacggcat acacgccgtc aatacgatat 872221 gccttttttc atatcgttga tgatacgaca aaagagtaat taatgttata atgatgggcg 872281 gataagaaaa acagaggtga acattgtggc attacatgtc gttttatatc aaccagaaat 872341 tcccgctaac acagggaata ttgcacgtac ttgtgcagca accaatacaa cgctacacct 872401 gattcgtccg ctcggctttt caacggatga taaaatgctg aagcgtgccg gactcgatta 872461 ttgggagttt gttaacgttg tgtatcatga ttcgttagaa gaattgtttg aggcatataa 872521 aaaaggcaag tttttcttta ttacaaaatt tggccagcag cctcatacat catttgatta 872581 cactgatctt gacgaggatt atttcttcgt gttcggaaga gaaacaagcg gtttgccaaa 872641 ggatttaatt caaaataata tggaccgctg cctgcgtctt ccgatgacag agcatgtcag 872701 atcgttaaat ctgtccaata ctgccgcgat tcttgtttat gaagcgctgc gccagcaaaa 872761 ttaccgtgat ttaaaatagt gaaaaacccg ctcatcgatg atgggcgggt ttttttgcgg 872821 atgttgaaat gctttgtttc gtttttgggc ttaacaacgt aacagtgtta tgttacaatg 872881 tacccatcaa aggagctgga cttatggaag aacaattaat ctctaaaaaa gaattacttg 872941 aaagaacatc gatttcatac ggtcagctgt atcgatggaa gcggaaaaac ttaatacctg 873001 aggaatggtt tattcgtaaa tccacattta cagggcaaga gacgtttttt ccgagagagg 873061 agattttaaa acgtatatca atgattcaaa agatgaaaga aaatttgtct ttggatgaaa 873121 tgagggaaat gctgtcgccg aaaatgaagg atgtcagcat gaccgctgat gaattgcttc 873181 ataaaggttt ggtttcaagg cctgctcttg aagcctattc agaagacgga ggaagtccgg 873241 ttttttcatc cagcgatttg ctttcgctgt ttgtgcttga gggcctgctg cagtctggaa 873301 atgtcagcct tgcagaagca aaaatggctg cagaggtatt aaagaagcat gatactgaag 873361 agattgaaaa acagacggag ctgattgtgc tccgcaagct cggtgtcaca acttgtttta 873421 tagcggctgc ggcggacagc attttgtttg aatcatccgt aaaggttgtg gaacgggtag 873481 atttattaaa agcttcagag gaattaaaaa caacatttat gcaggagggc catcaatgga 873541 tgtagtggaa aagctggtga taaatggatc aggaagttct aagggaggaa catttcaatc 873601 agttgagatt aatggcagcg ggacagtggc cggggacgtg gagtgtgaca ctttttcttt 873661 taatggaaac ggaaaagcgg acggcagcgt caaagcgaaa gcggtaacta tcagcggttc 873721 aggaaagata catggagacg ttgaagcaga atctatccgg atgaatggca ctggttttat 873781 tcaaggagag gtatctgcaa aacaattgaa aatcgctgga tcatcaacat ttggcggcac 873841 tgtcaaggct gatggaattg acattagcgg aaaagctgtc atggaagcag attgtgaaac 873901 agaaaccttt caatcagaag ggaaatgcaa aatcagcggg cttttaaatg cagaccaggt 873961 gatcattaag ctttctgcag gggaaagcta tgcgcgggag atcggctgcc gccatcttca 874021 agtgacctgc agaaaaggaa tgctgacatt gctcagattg atgccgcagc ctgttctaac 874081 agcagagctg atcgaaggtg acgtgattga attgacaaat acaaaggcga aaaccgtgcg 874141 cggtaataaa gtgatcatcg gcccggattg ccagattgaa accgtcgaat acagcgggga 874201 ctatacctgt gatccaagcg cgtcggttga aacatccaca aagttgtaag gaggatcgta 874261 atggagacaa caaaactggg aaatttaaaa ttatatggcg ctgggcatgc cgcaggaggc 874321 gcgtatcaca atgtcagcat caaaggagaa ggtatagttg gagaagggct gtctgctgta 874381 ggctgccgca tatacggaac gggccttttt ctcggaaaag cagagactga gcggctgcgt 874441 gtgctcggag aaagtgaatg taaaggcgat ctgacagccg gcaaaatcaa tatatatggg 874501 acaatgaaag tcagcggctc acttcaattt gatcgattca atctgaaagg ccagactgaa 874561 attggcggga atatgactgg agaatcctgc gatgtgaaag ggaagcttag cgtaataggt 874621 gattgtgaaa cagaaatgtt ccatgtcaca ggctgtgttg atgtatcggg gttattaaat 874681 tcgggtgaga tcaagctggg attgagccat gatataagcc atgtgcagga aatcggcgga 874741 acaacaatta cagtgaaaag acgcgcgagt ttttttagcc ggaagaaagg gaagctgatc 874801 gccgatgtca tagaaggaga tcgggtttat ttggagaata ccgaagcggc agttgtcagg 874861 ggaaaagaag tgatcatcgg gccgggatgc agcatcggaa cgattgagta cgaatacaaa 874921 tgtgaatgcg atccgcattc acagattaaa gaaaaaacaa aactgtaaaa cattgttctg 874981 ttatacaaaa agggtgctct ttcaggagca ccctttttta ttcttttcca ggcttgcttt 875041 cgtatcctgc ggtaaaaatt gatactaaaa aagtgacaat gacacccatc atgatgattg 875101 ttttcaccgt ctctccccct cttcaatttt tccgtgctgt ccgagtctgg atgattctgt 875161 atttttcttt attatgaacg gtcgcagtct gccttgtcaa cgatgtatga gtatctttat 875221 ttttaagaaa ccaaagcatg tatcacgaga tggcggcata gattgtatca aagtacctta 875281 tttgcatagt gtatcaaaca tgatagagga ggtccttatg gatatattaa agaaaattga 875341 aaagtacaga gaggaagagc agcggctgaa atgggaagga actttcgccg attatttgga 875401 gattattaaa gaaaatccga tggtcgcgca atctgctcat tctcgagttt ttaatatgat 875461 aaaagacagc gggatagagg agattgacgg acgcaagaag tacagttttt ttgaccgcga 875521 gctgttcggg cttgaagaat ctctggagcg tcttgtggaa gagtattttc atccggctgc 875581 caaacgtcta gatgtcagaa agcggattct attgctgatg gggcctgtga gcggcggtaa 875641 atccacgctg gtcacaatgc ttaaaaaagg tctcgaagcg tacacgctga cagataatgg 875701 cgctgtatat gcgattaaag gctgcccgat gcacgaggac cctctacatt taatccccca 875761 tcatttacgc gatgactttt acagagaata cggcattaga atagaaggaa gtctttctcc 875821 tttaaatgtc atgaggctgg aggaagagta cggaggaaga attgaggatg tgaaggtgga 875881 gcgcatcttc ttttcagaag ataagcgtac gggaattgga acattcagtc cctctgatcc 875941 gaaatctcag gatattgccg atttgacggg gagtattgat ttctcaacaa tcgccgagta 876001 cggttcagaa tcagatccgc gcgcttatcg atttgacgga gagctgaata aagcgaaccg 876061 cgggatgatg gagtttcagg agatgctgaa atgtgatgag aaatttctct ggcatttgct 876121 ttccttgaca caggaaggga attttaaagc tgggcggttt gcgttaattt ctgctgatga 876181 gctgatcgtg gctcacacga atgaaacgga gtatcgctca tttatttcta ataagaagaa 876241 tgaagccctg cactcaagaa tcatcgtgat gccggttcct tataatttaa aagtgtctga 876301 ggaagagaga atttatgaaa aaatgattgc agaaagcgat gtggcggatg ttcatattgc 876361 cccgcatacg ttgaaggtcg ccgcgatgtt ctcaatcctt acccggttaa aagagccgaa 876421 gcggtcggat attgatctgg tcaagaaaat gagactgtat gatggggaaa gtgtggaagg 876481 atataactct gtcgacgttg aggatatgaa aaaagaatat aatgatgaag gcatgagcgg 876541 aattgatccg cggtacgtga tcaaccggat ttcttcaacg attatcagaa aaaatatgga 876601 atcgattaat tctctcgatg tccttcgctc cttaaaagaa ggtcttgatc agcacccatc 876661 aatttcaagc gaggacaggg agcggtattt gaattttatc tctgccgccc gcaaggaata 876721 tgacgatatt gcgaaaaagg aagttcaaaa agcgtttgtt tattcatatg aagaatcagc 876781 aaaaacactt atggacaatt acctcgataa cgtagaggcc tattgcaata aaaacaagct 876841 tcgtgatcct ttgacaggag aggaaatgaa ccctgacgaa aagctgatga gatccatcga 876901 agagcagatc ggcatttcgg aaaacgccaa aaaagcgttc cgcgaagaaa ttttaatccg 876961 catctcggcc tatgcgagaa aaggcaagcg gtttgattac aattcccatg aaagactgcg 877021 tgaagctatt cagaaaaagc tgtttgctga tctgaaggat gtcgttaaaa ttacgacctc 877081 aacaaaaacg ccggatgagc agcagctgaa aaaggtaaat gaagtcgtgg cccgtttaat 877141 tgatgagcac ggctacaact cgacgagcgc caatgagctg ctgaaatatg tcggcagcct 877201 gctgaaccga taagcaacgt gacccgtccg aatagggcgg gttattttgt cccattttct 877261 aaatagtttg tcaattaaac gtgcatatgt gcatatgatg aatataaatc ttttcaaaag 877321 acttgtttca taatctggca caagccggaa tacgtatgta tcacgaccac aaatggttaa 877381 ggaggggaat tcatgtccca aaatgacagc ggccattttt tgatttctga ggaaaactgg 877441 tccctccatc gcaaaggctt cgatgaccag cagcgccacc agaaaaaagt gcaggaagcg 877501 atcaaaaaca atcttccgga cctcgtaact gaggaaagca ttattatgtc taatggaaaa 877561 gatgtagtga agatcccaat ccgttcactt gatgagtata aaatccgtta taactatgat 877621 aaaaataaac atgtagggca aggagacggc gagagccagg ttggagatgt tgtggcccgg 877681 gatggatcag acaaaaaaca agggcctgga aaagggcagg gtgccggtga tcaggcaggc 877741 gaggattatt atgaagcgga agtttcatta atggatttag aagaagcgct ttttaaagaa 877801 ttagagcttc cgaatctcca gcaaaaagag cgggacaata tcattcatac agatatcgag 877861 tttaatgata tccgtaaaac agggttaacc ggtaatattg ataagaaaag aacgatgatg 877921 tcagccttta aacgaaacgc aatgtcagga aaaccgtcgt tctacccaat ttatccggag 877981 gacctgaaat ataagacgtg gaatgacatc acaaagcccg aatcaaaagc cgtcgtttta 878041 gccatgatgg atacaagcgg cagtatgggg gtttgggaaa aatacatggc cagaagcttc 878101 tttttctgga tgacccgttt tttgcggaca aaatacgaga ctgtggaaat tgaatttatt 878161 gcccatcata cagaagcaag agtggtctcg gaggaggatt ttttctcaaa gggagaaagc 878221 ggcggaacaa tttgttcttc cgtatatcgg aagtcgcttg agcttattga tgaaaagtac 878281 aatcccgccc gctataacat ttacccgttt catttttctg acggtgacaa cctgacatct 878341 gataacgcgc gctgtgtgaa gctggtcaat gatattatga agaaggccaa tctgttttgc 878401 tacggcgagg tcaatcagta caacaggcat tcaacgttaa tgtctgcata taaaaatgta 878461 aaagatgaga aatttaagta ctatatttta aaacagaaat ctgatgtttt tcaggctcta 878521 aagaactttt tcagaaatga agagtctggt gtaagccatc aattttcgta atgaaaagcc 878581 catttcaggg ctttttttta tttaataaaa gcaagaaaac gcttgcgaaa aaaatacggg 878641 agaaaaagaa atttttcctt tgacaaatct tctttcattt attaatattt tatcttgtga 878701 actattattg aggaatgagg tgaaaaggag ttgactgaat cagaacgtgc tttgctcact 878761 tttgaacagc tcttcgatac gtctcgggcg atatataaaa aacagaagaa gatattggag 878821 attgtgcttg agccttttga tattacagtc cttcaatatt tgctgatgtt taaaattcat 878881 caaagcggaa gcaccccgct aagcaagctg gcaatgtcgc ttgatcttaa gcctgcttct 878941 gtgacgcgga tgacagatat tctgtataag cgccaattga tgaatcgata tgacagtccg 879001 gatgaccgcc gtatcgtcat gattcagtta accgaagagg gggaagaact gatagaaaaa 879061 gccgctgtgc aatatgcaaa aatgggtgct ggcttgtacc aaaagcttga tacctcccag 879121 ctgcagtatt tgcgcaaact agccggaagt ttaacgaagc ttgctgaagg ctgttcagaa 879181 aaaagcggta attaaaaact tctcacatat tttcaccagc tttccgcaaa atgatagagg 879241 atgaaacgaa aggagaaaac aaaatgaaca gaggacgttt aattctgacc aacattatcg 879301 gtttgattgt tgttcttgca attatagctg gaggtgctta ctactattat caaagcacaa 879361 actacgtaaa aacagatgaa gcaaaagtag cgggcgatat ggctgctatt actgctccag 879421 cagcaggtaa agtatctgac tgggatctgg acgaaggaaa aacagtgaaa aaaggcgaca 879481 cagttgcaaa aatcaaaggt gaacaaactg ttgacgtaaa atccattatg gatggcacaa 879541 ttgtgaaaaa cgaagtgaaa aacggacaaa ccgtacaagc tggtacaaca attgcacaaa 879601 cgattgacat ggacaaccta tacatcacag caaatattaa agaaacagat attgcggata 879661 ttgaagtagg aaatagtgta gacgtagtag ttgacggaga ccctgatact acatttgacg 879721 gtactgtaga agaaattggt tatgcgacta actcaacttt tgatatgctt ccttctacaa 879781 attcaagcgg aaactacaca aaagtaacac aaaaagttcc tgtgaaaatt tcaatcaaaa 879841 acccatctga taaggtgctt cctggaatga atgcatctgt taaaatttct gagtaaaaca 879901 gatcagtcat caaaccatga aaggaggttg tcttagatgg ctacaggcaa agaaaaaaat 879961 gcaaaaaacc ctatgtcatt gctgattgtg ctaatggcgg gtttattttt ggcaattcta 880021 aaccaaacac tgcttaatgt tgcaatgccg cacttaatga ctgaatttgg cgtaagtgca 880081 acgacgattc agtggctgac aacaggttac atgcttgtta acggtgtatt gattccgtta 880141 tctgctttcc tgattacacg atttggccag cggagtctct ttctcgtcgc gatgttttgt 880201 tttacgctcg gtacgttagt ctgcggtatc gcacctaact tctctacaat gctgatcggc 880261 cgtttgattc aggccgtggg cggaggtatc ttgcagccgc tcgttatgac aaccattctg 880321 ttaattttcc cgcctgaaag cagggggaaa ggaatgggga ttttcgggct agcgatgatg 880381 tttgctccag cggtcggccc gactctttcc gggtggatta ttgagcatta tacatggcgc 880441 attatgtttt acggacttgt gccgatcggc gcaattgtta tcattgtggc tttcttcatc 880501 tttaaaaata tggtggagcc gcaaaaaatc aaactcgata ctcttggcgc aatcctctcg 880561 attgtcggat tcgcctcctt attatacgga gtcagtgaag ccggatctga cggctggacc 880621 gacccgattg tattgtctac agttattatc ggagccattg caattgttgc ttttgttgtt 880681 cagcaattgc gtcatgatga tccgatgctt gatttcagag tgtttaaata tgacattttc 880741 tcactctcga gtgtcattaa tatcattatt acagtggcac tttacactgg tatgttcctt 880801 ttaccgattt atctgcaaaa cctggtcggc tttacggcgc ttcaatccgg tctgcttctg 880861 cttccgggtg cgatcgttat gctgattatg tcaccgatct caggtatttt gttcgataaa 880921 ttcggaccga gaccgcttgc gattatcggg cttctcgtga cagtggtaac aacgtatcaa 880981 tacacgcaat tgacaattga tacaccatat acacacatca tgctgatcta ttcaattcgt 881041 gcatttggta tgtctctctt aatgatgcca gtcatgacag ccgggatgaa ccagcttcct 881101 gcccgtctga acagccacgg aacggcgatg agtaacacgc ttcgccaaat cagcggatca 881161 atcggaacaa gtttaattac gacgatttat acaaaccgga cgacattcca ttattcacaa 881221 attgcagata aaacaagcac ggcggacccg aacttcctcc atgcgttcca aaatgcagtt 881281 tcgaatttaa tggtgaatat gaatgtgtct tatgatacgg cgaaaacata tgtgtactca 881341 catatttata aacacgcatc actcgattcc aatgtcatgg ggataaatga tgcctttatg 881401 tgggcaacct tattctgtgt agcaggtttg attttaagta tcttcctgcg tgacgtcaga 881461 aaagataaat tgcgtaagaa gaaaaaagag gagctttcat tacttcctgc tccaaaagaa 881521 gctaaggaat cttaatctgt acagggaggt ttcctgaatg aaaatttatg tagtgtatga 881581 tagtgaaggc gaacatacta aagtgcttgc agaagcgatt gctgaaggcg cgagagaaaa 881641 cgacgcggct gaagtgttca tcgaccatgt agatcaggct gatatccgca agcttaaaga 881701 tatggatgcg attatttggg gatgcccagg gcatttcgga acaatcagct ccggtcttaa 881761 aacttggatc gacagacttg gctacttgtg ggctgaaggc gagctgatca acaaagtcgg 881821 tgctgtcttc tgcacaacgg caacaacaca cggcggcttg gaaatgacaa tgcacaattt 881881 aatcacgccg atgttccacc aaggcatgat tgttgtcgga ctgcctggca acgtgcctga 881941 aaacgcactt tatggctctt attacggagc aggtgtcact tgtccggtag acagtgatga 882001 gttaatgtct gaggaaggta ttcagcttgg acgcgcgttg ggaagacgtg tcagccaagt 882061 cacaggaaac ctaacagcag gacagtaagg agaggttgaa atggccatta ttatagcaat 882121 aattgctgct gtcattgtca ttgcggccct tattacattt aacgtccgca acgcctcacc 882181 tggacctgag aagcaagaag caaccgatag aatcgcacct ccagaagagg aaaaaaacga 882241 agcgcattac cctgctgaag caagggctgc cgagcatacg ccatccgttg tcaaaaacga 882301 ttctccaaaa gagaagcgtg acacaatggg tgatgatatt tacaggcagg cgctgcaaaa 882361 gtttaagcat tctgatgaag ttcatgcaga agaagaggtc actgaggaaa gtgacaaaat 882421 gcaggaccgc agctatcgtg atgcgctgct ctctatgaaa aataagaaaa agtaatgaaa 882481 aaggcaaatc cgtttactca tgcgggtttg ccttttttgc tgtttccatc aattatgttt 882541 ttatcaaata aatccatgga atatgttgta ttccaccttg atctagtgta ctatgttact 882601 catacaccga ggattttttc cgggaggtaa agacatgaat tcttttttag gtttattaaa 882661 gaaagatatc aagctttcaa gaatgtggct gctagtatgg atatgcggaa tcattttctt 882721 attgggaaca ggccatatta tagcttctcg cacgaaagaa cctctagtca tttttggttt 882781 ttttgttgca gttgcttttt ttctgctttt cttatctcct gtttttgttt tttatcacct 882841 tcgcaaggaa gggaaatcac agctttggct gtacaatcca aatggcggct tatggctgtt 882901 ttcttctaaa ttggcagcat ctttgctcta tcaatttgtg attcagttgg cattaacagc 882961 ctatggcata tggatgtatc atatgctctc tgtaaaaaat ctgctggagc atcaagttga 883021 tataacgagt acagtggctt tgctgaatat gtatgggctt atttcttcgt tagatatgtc 883081 agtaacagtc attgtgtttt ggactgtttt tcactctctc agaaattggc gcggaatgcg 883141 gtgggctgcg atggttctgt tggtcgcaat gtggttattc ttcgatgaat acatcataag 883201 ccctttggtt gaatctcaaa agcatttctg gcctgtaaca gtctattgca attttgattt 883261 ccacttccac aatgtttgga gattggaact aaaacctatc catctgtctg tgctagggtt 883321 tcctattgct atagtcatca cattcttgct gctcatcatg gcttcaaaac tgcttgatcg 883381 taaagtagag gtgtaaatat ggacaatcaa ttccaatcct cgaaaccgat ttatctgcag 883441 atcgctgatc agatctttta taggctggtc aggaaggagc tgctcccagg agacaagctt 883501 ccttcagtaa gagaaatggc gattcaaact aaagtaaatc ccaatacaat tcaaagaact 883561 tacagtgaga tggaaaggct gggtattgtg gagacaagaa gaggtcaagg gacgtttatt 883621 gcggaaaaag cagaaatcgt agacgagctg aaagacaagc tgacacgaga ggtgctggaa 883681 ggctttgtca agcaaatgaa agagctgggg ctaacgaaag aagaaatgtt agaagggatt 883741 aaaacattca cagagggagg ctaaaatgga aatcaagcta gaacatgtat caaaaaaata 883801 cggccgccat acggccgtca atgatgtgtc aatcacccta tcatccggac ggatttatgg 883861 cctgattgga ccgaacggca gcggcaagtc aacgaccctg aaaatgatgg ctggccttct 883921 gtttccgact tcaggatttg taaaagttga tgaagagcag gttacgagag aaatggtgcg 883981 tcaaacggct tatcttactg agcttgatat gttttatccg catttcactg ttaaagatat 884041 ggtgaatttt tatcagtcgc agtttcctga ttttcataca gaacaggttt ataagctatt 884101 gaatgagatg cagctgaatc cggaaaaaaa gatcaaaaag ctatcaaaag gaaatcgggg 884161 caggctgaaa atcgttcttg ctttagcgag acgggcagac gtcatcttgc ttgatgaacc 884221 tttttccggg cttgatccga tggtcaggga ttccatcgta aacagccttg tgtcgtacat 884281 tgattttgag cagcagattg tcgtgatcgc gacacatgaa attgatgaaa ttgagacttt 884341 gttagatgaa gtaatcatcc tcgccaatgg agaaaaagtt gcgcagcgtg aagtagaaga 884401 tattcgtgaa caggaaggca tgtctgtttt gcaatggttt aaatcaaaaa tggaagtttg 884461 ctagaaagag gaggaatatg atgaaaacag tgttggaatt gaaaaacgtg actaaaaaca 884521 tcagaggccg aacgatcatt gatgatctca gttttacgat tcgtgaaggc gaggtattcg 884581 gttttttagg accaaacgga gcggggaaaa cgacaaccat ccggatgatg gtggggttaa 884641 tgaagctgtc gaaaggtgat gtcctcattt gcggccaatc aattacgaaa gaatatgcca 884701 aggcgattaa gcatatcgga gcgatcgttg agaatcccga gctgtataaa tttttgagcg 884761 gatataaaaa tctccagcaa ttcgcaagga tggtcaaggg tgtcacgaag gaaaaaattg 884821 atgaagttgt tgaactggtc ggtttaacag acagaatcca cgacaaggtg aaaacatatt 884881 ctctggggat gagacagcgt cttggcttgg cacaatgcct tctgcacgat ccgaaagtgc 884941 tgattttgga tgaaccgaca aacggccttg atccggcggg gatcagagaa atcagagatc 885001 atttaaagaa gctgacccga gaaagaggaa tggctgtcat cgtttcaagc cacctgctgt 885061 cagaaatgga actgatgtgt gatcgaattg cgattctgca aaaaggaaag ctgatcgata 885121 ttcaaaatgt aaaagatgaa aacattgatg agaatgatac atatttcttc caggttgagc 885181 agccgagtga agccgctact gttttaaatc agtacgattt gctgagtaag acaaatggtg 885241 tagaaatcaa actggctaaa gaggaagtcc ctgcggttat tgaattgctg gtgatgcagc 885301 aaatccgtat ttatgaggtc aaggtcataa caaaatcatt agaggaccgt ttcttagaaa 885361 tgacaggtga aacaaaagag gaggttcagc atgcttaatt tgatttataa tgagtggctc 885421 aaaattttca gccgtgccgg aacatgggtg atgatcggaa ttctggggct gacaatggtt 885481 ggatttgcat ttttggcgaa tcatttttct gccggtgaat caaattccca ttggaaacaa 885541 gagcttcaag cacaaaacgc cgaattaaag aaagaaatca aagaagatcc ttcactgaaa 885601 gatgggtata aagaaacaat cacactcaat gactatcgca tcgagcataa tatccctagt 885661 gacacgggct atacggtatg gtcttatgta acggattcag caaactttac catccttacc 885721 ggtctgttta ctattatcat cgcggccgga attgtcgcga acgaatttaa ttggggaacg 885781 attaagctat taatgattcg gccgctcagt cgttttcaaa ttttgatgtc caaatatatt 885841 acagttctcc tgtttgggct cctgttgctg ttgattttat ttatcggttc tactttatta 885901 gggttgatct tcttcggaac gggtggtgaa accgccgcga atattcattt aatctataag 885961 gatggccatg tcattgagca aaacatgatg gggcatttgg ctacaacgta tctttctgaa 886021 tccgtctcgg ctttaatggt ggcgacgatg gcgtttatgc tgtctgcggt attcagaaac 886081 agctctcttg cggttggttt ttccatcttc ttgttggttg ccggtacgac tgcaactgca 886141 tttattgcag cgaaatttga ctgggcaaag tatatattgt ttgctaatgt cgacttgact 886201 cagtatgtgg atggcacacc gttaataaaa gggatgacta tgacgttttc tctcgtcatg 886261 ctggcgatct actttatcat cttcctgttg cttgctttcg gaatcttcat gaagcgggat 886321 attgcaaact aataaaaaaa gctgttttgc ttatgcaaaa cagctttttt gtcaaaataa 886381 aaactgcagg tttgcacctg cagtttttca tatcaattta tgcttacgct tctttagtaa 886441 cgttagcagc ttgtggtccg cggtttcctt caacgatttc aaaagaaaca gcttggcctt 886501 cttctaaagt tttgaagcct tcgccttgaa tagcagagaa atgaacgaat acatcgtctt 886561 gaccttctac ttcgatgaat ccgaaacctt tttcagagtt gaaccatttt actttacctt 886621 ctaacatgaa atttcctcct aaagcgatca taacgcttaa attcactatt cttgctctta 886681 acaaactttc aagacgaaaa ctcttacaaa actttcttct taaagatagt tcgaacaaaa 886741 ataattacct ttactctacc agtaatcttc agaaaaaaca actgcttatt gaaatttttt 886801 tcggaaaata ccatatttat ttttcaattt gatatttatt tacggaaatt catctgtttt 886861 ctcgatatgt gatcatacgt ttgccttagt attccttcat tttgggaaga taagtaatag 886921 gaattgacaa ccttattgga tatgagtaag gtaaaagtta atcaatatta caaatgacaa 886981 cgtttatcaa ctaagagagc gtatgatttt tatgtctgat attgcttgca tgctctaata 887041 catagatagg agtatggtca caatgaaaaa gtggcttata tgcagtttcg tccttgttct 887101 tctcgtttca tttactgcat gttcaccgtc tgcagaacat gaatcgataa aaatcgggat 887161 tgctgagtct gacggggcaa tatggaacta tattgctcaa aaggctgaag aggcagggct 887221 ggatattcag ctgatccctt tttctgatta tgcggagtct gatatcgcac ttgctaacaa 887281 agaaattgat gccaacgcct ttcaaaccat ttcatatttt cagtcgttca ctgaaaaata 887341 caaacttaat ttggcaccgc tcgggacgac atacataacg cccatgggca tttattcaaa 887401 acgatatgaa cgaatccgag atatatcgcg gggagctgtc gtttctgttc cggataaagc 887461 gttcgatttt ggcagggcgc ttacggtgct ccaggaagcg ggtttgctaa cgctgaaaaa 887521 cggatttaac ggaacaggtt cagttgatat gattaaagat aatccgagac acctgaaatt 887581 aaaagctgtc cggcaacagg atgcagtgag cggtgccgac gtgtttgtca tgaaaccatc 887641 agaagcaaaa aaagcgggct tgaacccgaa aaagcatacg ctaaagagcg gcggactcat 887701 gtctgaggaa gagatgaatt tgattgttgt cagagcggag gatcaagatc gggaagcgct 887761 gcaaaccatt cttgagcttt atcaagctga tgatacagcg gcatttatag aaaaagaata 887821 tcagggagat cttgtcccgg cttttctgcc tttgaaacgt ctttcagatt ggaagaatga 887881 attcgaacat tgaattcatt cttttttttc tgaaaaacac actctgttcc gtcccgtttc 887941 tttcgctttg taaagcattt gatcggcaag aatgggcaag gatcctggct gttccgtatt 888001 attggggtaa tgagcggccc ctagtgatat cgtaactgaa agctcgtcgc cgtttgttaa 888061 tacaatcggt gcatcactta cagtgctcct gatccgttca gcgatccggg ctgctttatc 888121 aagagaacag ttcggcagga gcacggcaaa ttcttcaccg ccgatccgag cggcaggatc 888181 agtatttcgg atggtctgct tcagacgtaa ccctagctct ttgagcacct gatctccttc 888241 atgatggcca tattggtcat tgatggtctt aaaatgatcg atatccatat aaatcagtgc 888301 aaattgaaaa tgcggggtat cggccgcctg ctgatacaga gcttttgtgg tttcttcaaa 888361 ttttcttcgg ttatacacgc ctgttaaaaa gtcaaagtgc gcctgaaact tatattgttt 888421 aaaaagaaga tgtgcatttg tttcatgatc aataatatat aaactgagca tgccgcccgc 888481 tattgatatg atccaaaaat acaaatgaag ttcgtatgaa tgtaaatcta taagaaaata 888541 aaaggaaaag gagatcaagc tatttgtgat tattaaaaga tagaaagcat gttttagttg 888601 aacttttttt cttctagaaa caatgagtga cggaatggca gcgatacaaa tgataataac 888661 cgagtatagt gcagatgtgt tcatcgtaat cagcaagcgg cctgcagtga tcatggccag 888721 ggccgttgcc gttgaaaccc agcctccata aagagcggca atcataatag ggatatttcg 888781 aagatcaata attgaatgct gataggtaaa tccaaaaacc atcagaataa ccccgagcaa 888841 accgcaggcc agtcctttaa cagcttgaaa ggatatgctg tcttttttat gtactagcct 888901 ttctttaaac aggtgggtga agagataatt aaatgtgatt aaaatggtca aatttacaaa 888961 cagttctttc agcaaatatt atcaccctta tataaggtac taaagatgga agggaaagaa 889021 aagaacaaaa aaggcattat ataaggtttt tttacttgaa ttgataagtt aaaataattc 889081 gcacttgacc catcggaatt agtgtaatat agtaaatgag aaaatttgaa gggagagttt 889141 acctgctttg gagactttac tggttgtatt acatgtattt attttatttt tacttatctt 889201 agggctcttt gttatgcaga aaaaacatgt ttccttctct aaacgtgtat ttactgcgct 889261 ggggctgggg attgtattcg gatttgcgct tcagctgatt tacggcccga cttcaaatat 889321 agtcattcaa acagccgact ggtttaatat tgccgggggc ggatatgtca aattgcttca 889381 gatggttgtc atgccgctcg tctttatttc gattctcggc gcctttacaa agctgaagct 889441 gacaaaaaat cttgggaaaa tcagcggttt gattatcggg attttagtag caacaacagc 889501 agttgctgca gctgtcggta tcgcgtccgc gctttcattt gatctgcagg cgattcaggt 889561 tgaccaagga agtacagagc tttcacgggg acaggagctt cagcagaaat cagaggatat 889621 gacagcgaaa acgctgccgc agcagattgt tgaactgctg cctggaaacc cgtttttaga 889681 ttttacggga gctagaccga cttcaacgat cgctgtcgtt atttttgccg ctttccttgg 889741 agtggcattc ctcggcgtaa aacacaaaca gccggaacag gcagaaacat ttaaaaaact 889801 ggttgatgcc gtttatgcca ttgtcatgcg tgttgtcaca ctcattttga gactgacgcc 889861 ttatggggtg ctggccatca tgacaaaaac aattgcaacg agtgatcttg acagcattct 889921 aaaactgggc atgttcgtga ttgcatcata tgccgcgtta atcactatgt ttatcattca 889981 tttgctgctg ctgacgttca gcggcttgaa tccggtgatt tatttgaaaa aagcggtgcc 890041 tgtacttgta tttgcattta cgtcaaggtc tagcgcaggt gctttaccgc tgaatattaa 890101 aacacagaga agcatgggtg taccggaggg aatcgcaaac tttgccggtt cgttcggtct 890161 ttcgatcggc caaaatggat gtgccggcat ttatcctgcg atgctggcga tgatgattgc 890221 tccgactgtc ggccaaaatc catttgaccc ggtgtttatt atcactgtta tcgcagtcgt 890281 tgccatcagc tccttcgggg ttgccggagt cggcggcgga gcgacattcg cggcgcttct 890341 tgttttatca tcattaaaca tgcctgtcgc gctcgccggt ttgttaatct caattgaacc 890401 gttaatcgac atggggcgta ctgctttgaa tgtcagcgga agcatgacat ccggtcttat 890461 tacaagtaag gtcacaaaag aaattgatca aggggcattt catgatcaat ccagagtgat 890521 tgaagctgaa gaagcgtaac atatgaaaac gtgtaatcca agaggattac acgttttttt 890581 aacggccagg ctctaagtcc tccagcattt ccatcatcgt gttgtcgtcc atgacattca 890641 ttgcgttttg ttcaaaatga atgggttcag cataatgcgg ctgtcttttt ttcgcggctg 890701 tctcagtttg cctagtttga gactgtgtat gctgatgctg tggttgctgc tgtccagcgt 890761 gctggtgctg acggccattt tgccgctggc tttgatgctg cgaacggtcc tggttatcac 890821 cgctgcttcc gctgcttccg ctaaatgctt gtttgaccat gtttcctaca ttagaagcat 890881 caaacgtgtt attttctgaa tttcgtctgt tcatttgtcc tgtgataaac ccgctgattc 890941 tttggcggat ctgaggtgat aatgcagtaa taagcatagt tgatcctatg atcaatgctg 891001 cggggctgat tcctcttcgc tggttgaaca acatgatccc tcctttgcag tgtattcata 891061 ttttccccct cgttagacaa attaaccgtt atatttcccg ggaaagcatt tcctccagat 891121 ttgcatgcat aattaaagcc agttagaaaa acctataagt aaagtgataa aggaggaatt 891181 cacatgtttg gaaaaaaaca agtccttgcg tctgtgcttc ttatcccttt gcttatgact 891241 ggctgcggtg tagccgacca aggtgagggc agacgtgata ataatgatgt aagaaacgta 891301 aattatcgaa atccggccaa tgacgatatg cggaatgtaa acaatcggga taacgttgac 891361 aacaatgtta atgataatgt caataacaat cgtgtaaatg acgataataa caacgaccga 891421 aaacttgagg ttgctgatga agcagctgat aaagtaacag acctaaaaga agtaaagcat 891481 gccgatatca ttgtggctgg aaatcaagcc tacgttgcag tcgttttaac caatggaaat 891541 aaaggtgcag tagaaaacaa tctgaagaaa aaaatagcca aaaaggtaag atctactgac 891601 aaaaacattg ataatgttta cgtttcagct aaccctgatt ttgtagagcg tatgcaagga 891661 tatggaaagc gtattcaaaa tggtgaccca atcgccggat tatttgatga atttacacaa 891721 actgtacagc gtgtattccc taacgctgaa taaatgaaag aagccgcaca atttgtgcgg 891781 ctttttcttt gcgttaatga cacactgcga actcaggctg catagagtaa aaataaaaag 891841 gtacaagacg gaccggctca gggagggaga cgtttgcggg atggcatagg aaagcgtgcg 891901 gcatccgctc tattcctgtg cggagtcctt gtgatgctgg ctgtaagctc agccatcgta 891961 tcaagcgcga tgtatatcct gtcttttcca ggtcaggcat ctggaataac aaaagaacaa 892021 gtgacgaagc acatgaagaa agagtcattc aaacaggccg atatttatta cacttctaag 892081 gaaaagtcct tactgccatt gacgaaagaa acgcttgaat atgcggtcag tattaatcag 892141 attatgattg gatattcgaa tcaaaagcct attgacatta ttttttttcc taatgaaaaa 892201 cagatggagg cttactccgg tttattggat gtagttggtt tttattctga acgggagcag 892261 ctgatcggat tgttgcctga agagaaaaag aaactgttag aaggggacga ggtagcggtt 892321 tatttgtacc agagattgtt gattcatgaa tactcgcacc atgcgtttca ccagaaattg 892381 aaggagcttg agacggatcc cgatgagttt ccgttatggt ttcatgaagg gttaagcgag 892441 tggattgcga actatgaatt gctcatagat ccgatcacgt tttctgtcgt gccctttgac 892501 cgtttgcaga ctgatcgaga ctggcaggaa gctagagccg aatatgacac tgatgtctat 892561 ttgcaaagct tttatatgat cgatgagctg acggacaaat acgggaaaga cattatttca 892621 gaaatgatta aggaaacggc aaaaaaaggg gactttgaaa aagggtttaa atcagcaaca 892681 aaggaaagtc ttgatcaatt tgaaaaagat tttaagaaaa aatttgaaaa aaacagtgcg 892741 gcattggata gtatctatcc aatgcctttg ttattagtga agtccttgct gacccattcc 892801 gccttgtgtc ggaggcattt gtccttgggc aggggcgaat gaatttcgca gctgttccat 892861 atcctgcgca tcaagctgag gaacctggta atagccgtgt ttgttttggt ataggaaaat 892921 ttcaaatgcc atttcaacat actcctgaat ttgcgcagac agtacgcgtc ttacggccgg 892981 atttgtcatt tccagagaag ccatcgtcag catagaagct tgtgctttaa tcgcgcaaag 893041 catttgtcgg ctgatgatgc tgtcatcaat atcattcatg gattgaacag gttttttagg 893101 ctgtgacggc tgcatgccgt aaacagtctg gttgtcttcc ttcatcatat aagttgctgt 893161 tttttgtgaa ggttcgcttc ctgttttgaa gcattctgca gttatattgt attgagatgt 893221 gatgaattga tgttgacgat caaggatgtt tagtaattct tgatccttac agaattgtct 893281 cagcatcata aactgatcaa gcacagtaag tgttccggaa agcacctcat gcatatcaaa 893341 catttcatgt ccgccgtggt ttttatgcgg tttgccagga atacctttgt tcatttggga 893401 ttgctgctgc tgattgaact gatccaaacc gaattcctcc ttttttttca gatcagctgt 893461 attttgtgtc agtctgccgt gtattatgca gaagcctgaa aggaattata tgctgtctgt 893521 cgaaatgata agcagacaaa atcgttgtca ttatgtgtat aagggaggaa atatgatgag 893581 gcgtattctg catattgtgt tgatcacggc attaatgttc ttaaatgtaa tgtacacgtt 893641 cgaagctgta aaggcagctg aaccgcaaca gcctatatcg attgagaagg caatacagca 893701 aaaagaagga caggcacttg tcgaaggata tgcagtcggc caggctgttt ccccgcagca 893761 ttataaactg acaagccctt tttcaaatga ttataatgtt gcgctggcag accgtaaaaa 893821 caaaacatcg cccgaacaca tccttcctgt gcaaatcccc tccgccttca gaagccaatt 893881 tgggctgcaa accaatccgc ttcttcttgg gaaaaagata acggttcaag gaaagcttga 893941 aaattacttt aacacgacag gacttaaaaa cgttcagtcg atgaacgtaa ccgatgacac 894001 aaaaactccg ccggctgaac agcaagtgac cataaatgaa gcacggggaa ggctgaatga 894061 agaagtaacg ataaaaggga tcattacagc tgatcaaaac gcaatcggag gcgggaagct 894121 gtcgaccttt ttgcaagatg aaaccggagg cattaacatt tattcgccat cccctgaaca 894181 atttcccgaa ttaaaagagg gtatggatgt cacggtgaca gggaaaatca cgtcttacca 894241 ggggctgaaa gaaatcgttc caaactcatc aggcatcaaa atcaaccagt caaatcaatc 894301 cctccccgcc cccaaacact taacaatcaa tgaacttatt aacggcagcc taggtgatca 894361 gtatgaagga cgccttgtga aactaaccgc ttttgtttcc tcaattccaa gttctcctgc 894421 cggcggcggt tacaatgtaa caatgattga tgacgaccat catgcaatga cgctccgggt 894481 tatgaatgaa acaggggtga taaacgagct tgatgagggc aaatggtatg aatttaccgg 894541 tgtgttaagc agataccaaa cctttcagct gcttccgcga aaatcggctg acctgaagct 894601 gcttgaagag cagcccgcac ctccgtctgc agagggagaa tatgaaggga ttgttgaccg 894661 ggtagttgac ggcgatacca ttcatcttaa atctccggtg cttggaacga caaaaatccg 894721 gtttgtaaat gtagatgcac ccgaaacata tcacacacca aaaaatgacg cagatgaaaa 894781 tcaattaaga tttggcaaaa aagcatctga ctatctaaaa acggttctgt ccccgggtga 894841 taaaattact gtcaaggtcg ggagtgaagc caaggacagc tatggcagat tgctcggaca 894901 agtcataacc gaatcaggtt caaacgtgaa cttagagctt gtaaaaaacg gctatgctcc 894961 gacgtatttt atttggccgg ttgacaatga agaggattat cagcaatttc aggccgcagt 895021 agccgctgca aaaaaagatc aaaaaggaat ttggaatgaa aacgatcccc tcatggaaat 895081 gccgtttgaa ttcagagcca gagagcaagg gaaaggcctg acaagatatg tgggggactc 895141 gtcgaataaa acatatgtgc agccagctga ctggaagaag atagctgtgg aaaacagaat 895201 tttcttcgcc tcagcaagtg aagcggagag cgcgggatat aaaaaaaggc aaacggcacc 895261 tcaagaacat gtgccgctta gaattctcag catgaatgat ttgcatggca aaatcgatca 895321 gcaatatgag cttgatcttg atggaaatgg aactgtagac ggcacgtttg gacgcatgga 895381 ttatgccgcc gcatatttaa aagaaaaaaa ggctgaaaag aaaaactcgc tgattgtgca 895441 cgcgggagat atgatcggcg gaagctctcc agtttcctct cttcttcagg atgaaccgac 895501 tgtagaactg atggaggaca tcggatttga tgtcggaacc gtgggaaacc acgaatttga 895561 tgaaggcacg gatgaacttc tgaggatctt aaatggcggt gatcatccga aaggcacaag 895621 cggatatgat ggacagaact ttccccttgt atgtgccaat tgtaaaatga aatcaactgg 895681 agagcccttt ttgccggctt acgacatcat taatgtggag ggcgtacccg ttgcttttat 895741 cggagttgtc acacagtcgg cagctggcat ggttatgcct gaaggaataa aaaatatcga 895801 gtttacagat gaagcaacag cggtgaataa ggcggccgaa gagctcaaga aaaaaggcgt 895861 gaaggccatc gcggttctcg cacatatgtc agctgaacaa aacggcaacg ccattaccgg 895921 tgagtctgct gatcttgcaa acaaaacaga ttctgaaatt gacgtgattt ttgccgcgca 895981 taatcatcag gttgttaacg gtgaagtgaa tggaaaactg attgttcaag cgtttgaata 896041 tggaaaagcg ataggtgtcg ttgatgtaga gatcgataaa acgacaaaag acattgtcaa 896101 aaagtccgcg gaaatcgtat atgttgatca aagtaaaatc gaaccggatg tcagcgcgtc 896161 agccatttta aagaaatacg aaacaattgc ggaaccgatt atcagcgagg tagtcggcga 896221 agccgctgtt gatatggaag gggggtattc aaatgacggc gatacacctc ttggaaacct 896281 gattgcggat ggtatgagag ctgccatgaa aacggatttt gcccttatga atggcggcgg 896341 catacgtgaa gcgctgaaga agggtccaat tacgtgggga gatctttaca atattcagcc 896401 gtttggaaat gtgttaacga agcttgagat taaaggaaaa gatttaagag agattatcaa 896461 tgcgcaaatc tcgccggttt ttgggcctga ctacagcatc agcgggttta cgtatacgtg 896521 ggataaagaa accggaaaag cagttgatat gaaaatggca gatggcaccg agatccagcc 896581 cgatgccaca tatacattga ccgtcaacaa ctttatggcg acggcgacag gagccaaata 896641 tcagccaatc ggactgctgg gaaaaaatcc ggtgacaggg cctgaggatt tggaagcgac 896701 agttgagtac gtgaagagtt ttgatgagcc aattgcgtat acaaaagagg gaagaattaa 896761 gcttgctgaa gccagtgata ttgaagaccc tgtaacagaa gacccgataa cggaagagcc 896821 tggagatgat ccggggacgg aggatccgat taaagaggat ccaaggccag gtgaagattt 896881 gcctgatata aaagaaactc cgggaacagc accggttcat cagcttccgc cttcagccat 896941 ttcgagattc aatgaaatac caatcaacaa cacaaaaacc gctgatactg ctaatagcat 897001 cagcacattg ccgttacaaa ccgagactgc ggaaagcggg tctgatcatc agcttccgga 897061 tacgtcagcg ggctactata actttatggt aatcggtgcg gcggtgacat tgtcaggaac 897121 ttatctatat gtcagaagaa aaaggagcgc ctccagaacg tgaaaaaagt tattccacta 897181 ttcatcattg ctgccggcct agtgatcgca ggctatggag gctttaaatt gatcgatacg 897241 aatacgaaaa cggaacagac attaaaagaa gcaaagctgg cggctaaaaa gccgcaggaa 897301 gcttcgggga cgaaaaatag cacagatcaa gcaaagaaca aagcatcatt taagcctgag 897361 accggccaag cgagcggcat tttagaaata ccgaaaatca atgcagagct tccgatcgtg 897421 gagggcaccg atgctgatga tttagaaaaa ggtgtcgggc attacaagga cagctattat 897481 cctgatgaaa acggacaaat tgtgctgtca gggcatcggg ataccgtgtt tcgccggacg 897541 ggagagctgg aaaaggggga tcagctccgt cttctcctgt catatggaga attcacatat 897601 gaaattgtaa aaacaaaaat tgtcgataag gatgacacat ctattatcac gctccagcat 897661 gaaaaggaag agctgattct gacgacctgc tatccgtttt catacgtcgg aaatgccccg 897721 aagcgctata ttatatatgg aaaacgagtg acttaaaaag ccgaggcagt gcctgcggct 897781 tttcttcatg aaaaatatgt gcggcaaagg tttttcatat cagcagggaa aggggcttca 897841 gcaactatga gctcgtctgt tatcgggtga accgcttgta ctttattggc gtgcagtgcc 897901 tgcctgttta gcagcttgct cccgcctccg taaagcgagt ctcctgtcaa cggatggccg 897961 aggctcgcca gatgaacacg gatttggtgt gttctgcctg tttccagctc taattcaacg 898021 agcgacagcc gttctttcgc attgctggcc attaccttga aatgagtgac ggctgtttgc 898081 ccgcctggtg aaacccggcg tcttgtcggg tgtgagcggt ctctgccgat cggtgaatta 898141 attgtccctt ttttcgtccg tagcttacct tcagcgatag cggtatacgt acgcttcagc 898201 gtctttttct ctaactgctg gtctaagatg gcgtgtgcca aacgatgctt ggcaaaaacg 898261 atagcgccag atgtatcctg atcaagacga tggacgtggc gcaccttaca tgtttcgcca 898321 tttatctgat aatgatacgc gatcaaatta gccagtgtgc cggtttgccc atcctcattc 898381 ggatgcgtcg cgatgccagc gggtttattg atgatgagca tatgattgtc ctcaaataaa 898441 atatcaagct cgccatactc cggaatgacc gaagatgctt cactttcctg aagatcaatg 898501 aacacgcggt ctcccttttt tacaatcata ttgtttaaga cggattcgtg attgaccttt 898561 atctgttgat gggacatcca gtcttgtatc actggtttag aagctttgag cgctgttttg 898621 agtacggaaa acagccattg gccgtcctgt ttttcattga tgaggatctc aagccctctg 898681 cctttttggt tcatgttaaa tggctccttt tcgaagcgga aggctgctgt ttctcatagg 898741 aaacacttac cttagctttc gcgttttttt ctgtgctatt cttgagtaag acttaggata 898801 ttcgatggca agaaaggtga ttgacgtgag aattgtgaac gcagcaactg cagaacagga 898861 gagctttatc aaggagctgt ctatggagct gatccatgat gtatttcctc tttatttctc 898921 cgaactggac attcagcgct ttaaaaagaa aggcgttctg tctttaaata accattatta 898981 ccaaggaaca ttaaaagaag catttcaaat tatggcttgt ctgcaaatga tacatattat 899041 cctgaccaag ccttcgccgc actctgattt gagtgatcag gcgatttttg aaaaaaacag 899101 caagatgctg aatgattttg ggatttattt tccgtttgct ttttctgact ttcaaaagaa 899161 gactaacaaa gcctttttcg gtcaaagaag gctgatataa tcatgcggca agggcttttc 899221 tatttttaga aaagctcttt ttgtatcaga gaaatcatat cataaaacct ttcctctaac 899281 tcccttttta aacggctcgt gtctgaacat actaatgatt gaaaggggtg ctgacaatga 899341 gttcagttaa agatacaatg acaacgcagg tggcaaccgt ttctccgaat caaacgattc 899401 aggaagcggc ttctctaatg aaacagcata acgtcggggc gatccccgtt gtagagcaag 899461 gtgttttaaa aggaatgctg actgaccgtg acattgcatt aagaactaca gctcagggcc 899521 gtgatggcca gacacccgtt tcagaagtga tgtcaacaga actcgtatca ggaaacccta 899581 atatgagtct ggaagacgcg tcgcagctga tggcccagca ccaaatccgc cgccttccta 899641 ttgtagatca aaacaatcta gtcgggatcg ttgcgcttgg agacctggca gtcaatcaga 899701 tgtcgaacga gtctgcggga tcagcgctga caaacatttc tcaccaaaac attcattaat 899761 aagaaagagc ttgcagtgtg caggctcttt cttcacataa aaccttactt tttgaaagca 899821 gacttgtttc ggggtatagt gagtgtatac atatgtctca attcgtacta aaggagttgt 899881 acccagtgat taaagcgtta atttttgatt ttgacgggct tattctagat acagaaacac 899941 acgaatatga ggttcttcag gaaatatttg aagagcacgg ctcagtgctg ccgctatctg 900001 tctggggaaa ggtcatcgga actgctgcgg gtttccggcc ttttgaatat ttagaagagc 900061 agatcgggaa aaagctgaac catgaagagc tcacacaatt gagaagagag cggtttgcca 900121 aacgcatgga atcagaaaaa gcgagacctg gtgtcgaagc gtatttgaat gcggcaaagg 900181 atttaggctt aaaaataggc cttgcctcca gctctgatta taaatgggtg tccggccatt 900241 tgaagcaaat cggcctgttt gatgattttg aagttattca aacggcggat gatgtggaag 900301 aggtgaagcc gaatcctgaa ctctatttat tggcggcaaa gaacctgggg gtatcgccag 900361 cggaatgtct cgcgtttgag gattctgtca atggttcgat tgctgcgaaa cgtgcaggca 900421 tgaagtgtgt cattgtcccg aataaagtaa cgggtacctt gatgtttgaa gactatgatc 900481 acaggcttga atcaatggcg gagatggagc tcgccctatt gcttgatcat ctgaactcac 900541 aaaactagaa aggagcgagt aggttgtctg agaaattaga tttgacccgg tttgaaaaga 900601 aaatggttat ccgcaatatc gaagagaaag acatcgacaa gattatcgat cttcaaaagg 900661 actgctttcc aggaatggag ccttggaagc gggagcattt aatcagccat ttggagcatt 900721 ttccggaagg acagttttgt gcagaattcg aaggtgaaat tatcggttcg tgctcaagtc 900781 tcctgattaa ctttgatgaa tatgatgacc gccatacgtg gcaggacatt acagatgacg 900841 gttatatcac caaccataat cctgacggct tgaatatgta cggaattgaa gtcatggtgc 900901 acccgaaata cagacgaatg aagatcggcc accgtttgta cgaggcgaga aaggacttag 900961 ccagacgctt aaacctgaaa agcatcatca taggcggacg gattccaaac tatcacaaat 901021 atgcagagga aatgacagcg agagagtatg ttgaacaggt gacacgccac caaatttacg 901081 atccggttct ttcttttcag ctgatgaacg gctttaccct tatgcgaatt aacccgaact 901141 atctcccgga tgatacagct tcgatcaagt atgcgacgct gatggaatgg aataatgtcg 901201 attatctacc gcagcagaca aaacgctatt ataaatcggc gttccctgtt agaatttgtg 901261 tgatccaata cgaaatgaag aaaatttatt cctttgagga atttgcgaat caagtagaat 901321 actatgtcga tgttgcttcc gacgcaagat ctgattttgc ggtgttcccg gaaattttca 901381 caacccagct gatgtccttc cttgaggaac ggtcaccgag cttggcggtg cagagaatta 901441 ccgagtatac agaagattac atcagcctgt ttactgactt ggctgtgaag tataacgtca 901501 acattatcgg cggatctcat ttcgtcgaag aggaaggcaa gatctataat atcgcttacc 901561 tgttcagacg ggacggaacg atcgagaagc aatacaaact ccatattacg ccgaatgaac 901621 gcaaatggtg ggggatcagc gcaggagacc aagttcgcgt gtttgatacg gactgcggga 901681 aaatcgcgat ccagatctgt tatgacattg aatttcctga gcttgcccgg attgcggctg 901741 ataaaggagc caaaatcatc tttacgccat tttgtacaga agaccgtcaa ggctatctgc 901801 gtgtcagata ctgttcgcag gctagagcgg ttgaaaatca aatttatacg gttatctctg 901861 gaacggtcgg aaaccttccg caaacggaaa acatggatat ccaatacgcc cagtcaggca 901921 tctttgcccc gtctgatttt gaattcgccc gagacggcat tgtcggcgaa acaaacccga 901981 atattgaaat ggtcgtcatc ggcgatgttg acctggaaat tctcagaaga cagcgccaaa 902041 acggtacagt gcgccagcta aaagacagac gacgtgatat ttatcatatt caatataaaa 902101 aataattccc aaaaaacccg cctgaattgg cgggtttttt taaacaaaag cggaattgtt 902161 taggtgcttt ctttaaaata aaagtaaatt gtatagtgga tgtgccttat ggagtttctg 902221 tattttcgcc atttcctata tcatacagaa aacggctagg cttcacattg ctattgcaat 902281 ggctgtccaa gttgtttcga gtgcgacctt tatcagtacg atgctgagca ttgtcacttt 902341 gcctgttttg ctttggaagc tgcatcctct ttcttcttga gaaaggggat gttttattat 902401 ttacgcggtt tattgactct gacccggtct ggctttatat tgaaggcagg gaaatcatca 902461 ccaagacatc acataaagag aaggtctgtt tcaattgaat tggcattata gggaacgcta 902521 atgaaatgga gatgatgggg atggaaaaca ttcagcaaaa tcagggatta aagcaaaaag 902581 atgagcaatt tgtgtggcat gccatgaagg gagcgcatca agcggacagc ctgatagccc 902641 agaaggccga aggggcctgg gtaaccgaca cagacggacg ccgctatttg gatgcgatgt 902701 ccggtttgtg gtgcgtcaac attggttacg gcagaaagga gcttgcggag gctgcctatg 902761 agcaactaaa ggagctgcct tactacccgt taacgcaaag tcacgcaccc gcaattcaac 902821 tggcggaaaa gctgaatgaa tggcttggcg gcgattatgt tatttttttt tccaacagcg 902881 gatcggaagc aaacgaaact gcttttaaaa ttgcccgcca gtaccatctg caaaacggcg 902941 accacagccg ttataaattc atctcaagat atcgggcata ccacggcaat acattgggag 903001 cgctctcagc taccggacag gcgcagcgga aatataaata cgagcctttg agccaagggt 903061 tcctgcatgc agctccgcca gatatatacc ggaatcctga tgatgcagac acgcttgaaa 903121 gcgcaaatga aatcgaccgc atcatgacat gggaattaag cgaaacgatt gccggggtca 903181 ttatggagcc catcattaca ggcggaggca tcctaatgcc gccggacgga tatatgaaga 903241 aggtggagga catttgccgg cgccacggag cccttttgat ttgcgatgaa gtgatctgcg 903301 ggtttggacg gacaggtgag ccgttcgggt ttatgcacta cggtgtgaag cctgatatca 903361 ttacgatggc aaagggaatc acaagcgcgt atctgccatt gtcagcgact gctgtgaaac 903421 gggacatttt cgaagcgtat cagggggaag ctccttatga ccgtttccgc cacgtgaaca 903481 cgttcggcgg aagcccggct gcctgtgctt tggcgttgaa aaacctgcaa attatggagg 903541 acgaacagct gattcagcga tcccgtgatc ttggagcaaa gcttttaggt gagcttcaag 903601 ctctgagaga acacccggca gtcggggatg ttagaggaaa agggctgctg atcggaatcg 903661 aactcgtcaa agacaaattg actaaagagc cggctgatgc cgccaaagta aaccaagtgg 903721 ttgcggcgtg caaagaaaaa gggctgatca tcggcaaaaa cggcgataca gtcgccggct 903781 acaacaatgt catccagctt gcgccgccat tttgcctgac agaagaggac ctttccttta 903841 tcgtgaaaac ggtgaaagaa agctttcaaa cgatataata taaaagtgaa ttattaaagg 903901 agcacatgat gagttttcac aaccagccga tcttaccggc tattcgcaat atgaagcaat 903961 ttgatgagtt tttgaacagt tcattctctt acggtgttat tcttgatatt catctcggcc 904021 agctgaaggg cgtgatcaaa gaagcgcaaa agcacggaaa gaacatgatg gtgcacgtcg 904081 atctcattca agggattaag catgacgaat acggtgcgga atttatatgt caggatatca 904141 agcccgctgg gattatttcc acaagatcga atgtgattgc caaagcgaag cagaagaaaa 904201 tttatgccat tcagcgcctg tttttgcttg atacaagcgc gatggagaaa agcatggagt 904261 ttatcggcaa gcataagcct gacttcatcg aagtgcttcc cggcatcgtt ccgtcactca 904321 ttcaggaaat aaaagagaaa acagggattc ccatctttgc cgggggtttc atccgtacgg 904381 aagaggatgt agagcaggca ttgaaagcgg gggctgtagc tgtcacaaca tctaatacca 904441 aattgtggaa aaaatatgaa aactttttga cggaaagtga ttgacaccgc tttcatgcac 904501 tgatacaatt gcactaggtt aatacattgt gatggagaac tcggagacca cagcagctct 904561 ttacggcaaa tgtttatgca cccgtaaagc ggtttgttgt ggttttttta ttctcttctt 904621 ctctatcatg ctttttaatc gtgactttag gaggaatgtg ctatgacagc attttgggga 904681 gaagtcatcg gtacgatgct gcttatcatt tttggtgcag gtgtttgtgc aggtgtcaat 904741 ttaaagaaat cgctttcatt ccagtctggc tggattgttg ttgtatttgg atggggattg 904801 ggtgttgcca tggcggcata cgcggttggc ggcatcagcg gtgcccattt gaatccggcg 904861 ctaacgatag cgcttgcatt tgtaggagat tttccttgga aagaggttcc ggtttatatt 904921 gcggcgcaaa tgatcggagc gatcatcggt gcggtgatta tttatctgca ttacctcccg 904981 cactggaagt caacggatga tcccgctgcc aagctgggtg ttttctcaac agggcccagc 905041 attccgcata catttgcaaa cgttttaagc gaagtgattg ggacatttgt ccttgtactt 905101 ggaatcttgg ccataggtgc aaatcaattt acagaaggac ttaatccttt aatcgtcggt 905161 ttcctcattg tagcaatcgg tatttctctg ggaggcacca ccggctatgc tatcaatcct 905221 gcacgtgact taggtccgcg gatcgcccac gcttttcttc cgattccggg gaagggctca 905281 tcaaactgga aatacgcatg ggttccggta gtcggcccga ttttaggcgg atcattcggc 905341 ggtgtatttt acaacgctgc atttaaaggg cacatcacaa gcagcttctg gattgtaagc 905401 gttatattgg ttgtggtatt gttaggactc tatgtttata cgaaatcaca ttctgctaaa 905461 acattatcaa attctaaata tatttaatca aaggggagac atcttatgga aacgtacatt 905521 ttatccttag atcaggggac gacaagttca agagcgattc tgtttaataa agaaggcaaa 905581 attgtccact ctgctcaaaa ggaatttaca caatacttcc cgcatcctgg ctgggttgag 905641 cataatgcca atgaaatttg gggctctgtc ctcgcggtta tcgcctcagt catctctgaa 905701 tcaggaatca gcgcttctca aattgccggc atcggcatca cgaaccagcg cgagacgacg 905761 gttgtgtggg ataaagatac aggaagtcct gtctataatg caatcgtttg gcagtccaga 905821 cagacgtccg gcatttgtga ggaacttcgt gaaaaaggat ataatgataa attcagagaa 905881 aaaacagggc ttttaatcga tccttacttc tccggcacga aggtgaagtg gattttagac 905941 aatgtggaag gcgcaagaga aaaagcggaa aaaggcgagc tgctgtttgg aacgattgat 906001 acgtggctca tttggaaaat gtcaggcgga aaagcgcatg tgaccgatta ctccaatgcc 906061 tcaagaacac tgatgtttaa tatttacgat ttaaaatggg acgatgaact gctcgacatt 906121 ctaggcgtac cgaaatccat gctccctgaa gtgaagccgt cctctcatgt gtatgcggag 906181 actgttgatt atcacttctt cggaaaaaat atcccgattg ctggagcggc aggcgaccag 906241 cagtccgcat tgttcggcca ggcatgcttt gaagaaggca tggggaaaaa cacttacggc 906301 acaggatgtt tcatgctgat gaataccggg gaaaaagcaa ttaagtccga acatgggctt 906361 ttgacaacaa tcgcttgggg cattgacgga aaagtgaact atgcgttaga agggagcatt 906421 tttgtcgcag gctctgccat ccagtggctt agagacggtt tgagaatgtt ccaggattca 906481 tcgctaagcg aatcttatgc agaaaaagtg gattcaactg acggcgtgta tgttgttcca 906541 gcatttgtcg gactgggaac gccttactgg gacagcgatg tgcgcggttc ggttttcggc 906601 ctgacaagag ggacaacaaa agagcacttt atccgtgcga cactggagtc attggcttat 906661 cagaccaaag atgtgcttga cgcaatggaa gcagattcaa acatttcatt aaagacgctc 906721 cgtgtagacg gaggagctgt aaaaaacaat ttcctaatgc agttccaagg agacctgttg 906781 aatgttcctg tggagcgccc ggaaattaat gaaacgactg cacttggcgc ggcttatttg 906841 gcgggtatcg ctgtgggatt ctggaaggac cgttctgaaa tcgcgaacca gtggaatctg 906901 gataaacggt ttgagcctga attggaagaa gaaaaacgaa atgagctgta taaaggctgg 906961 caaaaagccg tgaaagcagc tatggctttt aaataaagta atactatggt ataatggtta 907021 caagttaata agaacggtcc tgagatgagg agagaccaca gcaccaaagt gtaagcatgc 907081 actttggctg ttgtggtctc tttttctatt taccgtgaca acaaggagga aacgtaatga 907141 tgaatcatca attttcaagt cttgaaagag atcgcatgct gacagacatg acgaaaaaaa 907201 catatgacct atttattatc ggaggaggaa ttacaggagc cggaacagct cttgacgcgg 907261 catcaagggg aatgaaggtc gcactaagcg aaatgcagga ctttgcggcg ggaacatcaa 907321 gccgatcaac gaagctggta catggcggct tgcgctattt aaaacaattt gaagtgaaaa 907381 tggtcgctga ggtaggaaaa gagcgggcga ttgtgtatga aaacggcccg catgtcacta 907441 caccggaatg gatgctgctt ccgtttcata aaggcggcac attcggttca tttacaacat 907501 ctattgggtt aagggtttat gacttccttg caggtgtgaa aaagtcagaa cgaagaagca 907561 tgctttcagc aaaagaaacg ctgcaaaaag agcctttggt gaaaaaagac ggcttaaaag 907621 gcggcgggta ctatgtggaa taccgcactg acgatgcgag actgaccatc gaagtcatga 907681 aggaagcggt taaattcggg gcagagcctg tgaattactc caaagtgaag gagcttcttt 907741 acgaaaaagg caaagccgtc ggcgtattaa ttgaagatgt gctgacaaag aaagaatata 907801 aagtgtatgc gaaaaaaatt gtcaatgcta caggcccttg ggtcgatcag ctcagagaaa 907861 aagaccattc gaaaaacgga aagcatttgc agcatacaaa aggcattcac cttgtatttg 907921 accagtctgt ctttccgctg aaacaggctg tatatttcga tacacctgat ggccggatgg 907981 tatttgcgat tcctcgtgaa ggcaaaacat acgtgggaac aacagacact gtttacaaag 908041 aggcgctgga gcatccgcgg atgacaacgg aggatcgtga ttatgtcatc aaatcaatca 908101 attacatgtt cccggaactg aatatcactg cgaatgacat cgaatccagc tgggcggggc 908161 tgcgtccgct gattcatgaa gaaggcaaag atccttctga aatttcacgg aaagacgaga 908221 tttggacatc tgactcaggc ctgatcacca ttgccggcgg aaaactgact ggatacagaa 908281 aaatggcgga gcacatcgtt gatcttgtcc gtgatcgctt aaaagaagag ggcgaaaagg 908341 attttggacc atgtaaaacg aaaaacatgc caatctctgg cgggcacgtc ggcggttcga 908401 aaaatcttat gtccttcgtt accgcgaaaa caaaagaagg aattgcagcc ggtttatcag 908461 aaaaagacgc aaaacagctt gcgatcagat acggctctaa cgtagatcgc gtctttgacc 908521 gggtagaagc gctgaaagat gaggccgcga aacgcaacat tccggttcat attcttgctg 908581 aggcagaata cagtatagaa gaagagatga ctgcaacccc tgctgacttc tttgtccgca 908641 gaacgggacg tttatttttt gatatcaatt gggtaagaac atataaagat gccgttattg 908701 attttatgag cgagcgattc caatgggatg agcaggcgaa aaacaaacat acagaaaacc 908761 tcaacaagct tttacacgat gcggtcgtac cgcttgagca ataaatcata acgggctgtc 908821 tgcagcccgt tatttctttt tacgtgccga aagggggaga tctcaggtta tcaagtgaca 908881 gaggcacccg cttcatataa aataatggca taagctgata cataggagga cgaatatgac 908941 ttggagaaag agctatgaac gctggaaaca gacagaacat ttagatctgg aattaaaaga 909001 gcgccttatt gaattagagg gagatgaaca ggcccttgag gactgtttct ataaagacct 909061 tgaattcggt accggcggaa tgcgcgggga aatcggcgcc gggacaaatc ggatgaatat 909121 ttacactgtg cgcaaagcat cggccgggtt tgcggcatac atctcgaagc aaggtgagga 909181 agcgaaaaaa cggggcgttg tcattgctta tgattcccgc cataagtctc cggagttcgc 909241 gatggaagcg gcaaaaacac ttgcgacaca aggcatccaa acatacgtgt ttgatgagct 909301 tcgcccgacg ccagagctgt cattcgctgt tagacagctg aacgcttatg gtggaattgt 909361 ggtaacggca agccataacc cgcctgaata taacggctac aaagtatacg gggatgatgg 909421 cggccagctg cctccaaagg aagcggacat cgtcattgag caggtaaacg cgattgaaaa 909481 tgagctgacg atcacagtgg acgaagaaaa taagttaaaa gaaaaaggct taatcaaaat 909541 catcggtgaa gatattgata aagtttatac agaaaaactg acgtccattt ctgtacatcc 909601 tgaattatcg gaagaagtag atgtaaaggt tgttttcaca ccgctgcatg gaactgcaaa 909661 taaaccggtc agacgcggtc ttgaagcact cggctacaaa aatgtaacgg ttgtcaaaga 909721 acaggaactg ccggattcaa acttctccac tgttacatcg ccgaacccgg aagagcatgc 909781 ggcattcgaa tatgccatta agcttgggga ggagcagaat gcagatattc tcatcgcgac 909841 agatcctgat gctgaccgcc tcggcatcgc ggtgaaaaac gatcaaggca aatatacagt 909901 gctgacagga aaccaaaccg gagcgttgct gcttcattac ctgctttctg aaaagaaaaa 909961 acaaggcatc ctgcctgata acggtgttgt tctcaaaacg atcgtcacaa gcgaaatcgg 910021 ccgtgctgta gcttcttcat tcggccttga tacgattgat acgctgacag gctttaagtt 910081 tatcggtgaa aagattaagg aatacgaagc atcaggccag tataccttcc aattcggtta 910141 tgaagagagc tacggttatt taatcgggga ttttgcccgc gataaggacg ccattcaggc 910201 tgcgcttttg gcagttgaag tttgcgcgtt ctataaaaaa cagggaatgt cattgtatga 910261 ggcgctcatc aatctcttta acgaatatgg tttttatcgt gaagggctga aatccctgac 910321 gctgaaaggc aaacaaggag cagagcaaat tgaagcgatt cttgcttcct tcagacaaaa 910381 tccgccgcag aaaatggcgg gcaaacaggt tgtcacagca gaagattacg ctgtaagcaa 910441 acggacgctt ctgactgaaa gcaaagaaga agccatcgac ttgccaaaat caaatgtatt 910501 gaaatacttc ctggaagacg ggtcttggtt ctgtctccgt ccttctggaa ctgagccgaa 910561 ggttaaattt tatttcgccg taaaagggtc atctttggaa gacagtgaaa agcgacttgc 910621 cgtcctttct gaagatgtaa tgaagacggt ggatgaaatt gttgagtcaa cagcaaaata 910681 attcaagtat gagctgggtc attgtaaatg atccggcttt ttctttttct catccaaaag 910741 tctgaaagaa aatcatccta caagtgaagc aatgaaatac aaaaaactgg tataatctta 910801 aatacaagat caatgccgga gtgagaaacg tgagcaaaac gaggatggaa aaattaaaaa 910861 cgctgaaaac gattgcggaa accttaaatc aagggcacga tatcaaagca acactggatg 910921 aggttttaaa agagttgctg agtctgacaa accttcaatc cggatggatt tttctgatcg 910981 aagaagatgg gtcttatacg ttagcggccg acgcttatct gcccccggct ttaagccgca 911041 aggaaaaagt gctgatgtgc gaaggggagt gttactgcct gacgaaattc aataacggag 911101 ggcttagaaa agctgcaaat atcatgaact gcaaacgcat cgaatcagca gaaaacctgc 911161 attgttttga cacagaaggg attacgcatc atgcaactgt gcctttagaa gacggggaca 911221 gaagattcgg attgttaaat gtagcggcgg ccggaaaaac catgtttgat gaggaagagc 911281 tgcatttact cgagtctgtc gcctttcaga tcggaacggc aatccagcgt atgaggcttt 911341 ctgaatatca acaaaaaaat gctcttttaa tggagcgtaa ccgcctcgct caggagcttc 911401 acgattcagt caatcaaatg ctgttttccg tcagtttaac tgccaaagct gcgaagacac 911461 taacaaaaga tgaaaattta cagcagatga ttgatttcat ccaaaaccta tcacaggacg 911521 cgctcgcaga aatgaaagcg ttaatttggc agcttcgccc cggaggattg gaaaaagggc 911581 tggctgaagc cattaaaagc tatggtgcgc tcattggatt gaagatcatt tttacacaaa 911641 aaggctgtcc tgttctgact gatgagcagg agcatatgct atggcgtgtc gtacaggaag 911701 ctttaaataa ctgcaaaaag catgccggaa cggatacggc gtatgttagt ctgactgctt 911761 ctttgtgcca tgcggagctg gatatcatcg atcatggggc aggatttcgc tatgaagcgc 911821 atgccggtct gccttcactt ggcataaaag gtatgaaaga gcgagcggaa aaagccggag 911881 ctaagttttg gattgagtca gcgcttggaa ctggaacaaa gctgtccatc aggcttccgc 911941 taaaaagccg aaaaggaggg gcggtatgaa aattgtcatt gctgatgatc atcatgttgt 912001 cagaaagggt ctgcgttttt tctttgccac ccaggatgat attgaagtcg tcggagaagc 912061 tgcaactgga ttagaagccc tccgtgtcat cgaagagaca aagccggatc ttgtgctaat 912121 ggatttgtct atgcccgaga tggacggcat tcaagccatt aaaaaagcaa tacagcaatt 912181 tccggatacg aatatcattg tgctgacgag ctactctgat caggagcacg tcatccccgc 912241 gcttcaggca ggcgcgaagg cgtatcaatt aaaggatacg gagcccgagg aattggtgaa 912301 aacacgacaa gtgcatggtg gcgaatacaa gctttctaca gctattatgc cccatgtgct 912361 gacacatatg aaaaatcagc acgacccgga aaaagaaaaa tactatcaat taactagaag 912421 ggaaaaagac gttctgactg aaatagcgaa cgggaaaagc aataaagaaa tcgcagcagc 912481 cttgtttatt tcagaaaaaa cagtaaaaac ccatgtatcg aatcttttag caaaacttga 912541 agtggccgat cgcacgcaag cagcgctttt cgcagtgaaa tataacctga atggagagat 912601 ctcaaaatga acatgttagt cataaatggc acgccaagaa aacatggcag aacaagaatt 912661 gcagcatcct atattgcagc tctgtatcac acggatttga ttgatctaag cgagtttgta 912721 ttgcccgttt ttaacggtga agcggaacaa tctgaactgt tgaaagtaca ggagcttaag 912781 caacgcgtta cgaaagcgga tgcgattgta ttattatcgc ctgaatatca cagcggcatg 912841 agcggcgctt taaaaaatgc cttggatttt ctaagcagcg aacaattcaa atataagccc 912901 gttgcattat tggcagtagc gggaggcgga aaaggcggca tcaatgcgct gaacaatatg 912961 agaactgtga tgcggggtgt ctacgccaat gtcattccga agcagctggt gcttgatccg 913021 gtgcatattg atgttgaaaa tgctacagtg gctgaaaaca ttaaggaaag cataaaagag 913081 cttgtcgaag aactcagcat gttcgcaaaa gcaggaaatc ccggcgtcta aacgccggga 913141 tttgtttatg tgagaagggc tatttgatct tcataagtca gctctgtggc atgatcaata 913201 tatcggagaa gggaatacag catcttttct aaaacggcgt aatcctgttc aaaatgatac 913261 gcatgcagaa aatgctcaat tcgttttgat aacaaatcgt cctctgtacg caccattaaa 913321 attaataaat tatcccattg agaacgatgg gtgtaataaa gcgctttatc gtaatcggca 913381 taatccatga atcgcttctc ctttcttggg tgagaagttc atgattagtt tatgccgcat 913441 cctctgttat tgacggggca aaacttgccg tctgcgtcag taaaggggta gcaatatgag 913501 ggagacataa aatcaaaatg cctgaatgaa gatatcgctt ttggtaaacc tatgagggaa 913561 tatattctgg gtacaggaga ctgaaaaaat gaaatccctg ccgtatacca tcgcacttct 913621 tttttgcgga ttgattatcg tgtcaatggc tgcaaaaggt cattcaacgg acacagacga 913681 gtccgttcaa aagtgggaac agcttgcctg gagcaaaatt caggatgaat ataagggcgc 913741 ttcattttct gattatgctt atatggggcg tacagaggtg aatgatcagc agactaaaga 913801 tgtctttcgg gtgacagtca gacagaaaga tgacactttt tctgttcggg ccgaagtcta 913861 ttttcatccg gtgacaaatc atatgatcag catcaacgtc tttaggctct aataaaaaac 913921 tgtacagccg ttaaggccgc acagtttctg tttttagaaa tatcgttttg caccgagata 913981 gcgctgtttc cagtaagagt tgttcatatt ggaaatgaca actccggaat cgttggcatt 914041 tatgaattcc ccgttgccta ggtaaattcc gacgtgggaa gggccggctt tatatgttga 914101 aaagaaaacg aaatctccga cagcaggctg gctaactgat ttcattgtgt tccaatatcc 914161 cgctgccgtt aatctagata cggatgtgac tttgttcagt acatagtaaa tgaatccgct 914221 gcagtcaaac ccggacggtg tcgtgcctcc ccagcgatac ggaaccccaa gctgcgcttt 914281 agcggccgaa atcattgtgt taatcttcgc actcgttgag ctggtggtgt ttgaagaacc 914341 ggatgaagac gatgatgaag cttttccgga aatgaccagc ttttggccaa cctgcaagac 914401 atccgttttt aaattgtttt tctcacgaat ctgctgagct gttacattaa atttttgagc 914461 aatcacccat aaggaatcac cgcttttcac cgtgtatgta gtcgtcgtgc cggagcttgc 914521 atttgacgaa gaagacgacg atgatgaaga gcctgaagat gctttacctg tcagcttcaa 914581 tacttgtcca acgtaaagca catctgattt cagattgttg atatttcgga tttgctgtac 914641 agtcaggtta tagttgtttg cgattttcca aagtgaatca ccgcttttaa cggtatattt 914701 agttgttgct gaagtttggt tcgatttgga tgaattgtct ttagaagacg tatcagagcc 914761 gcttgatttt gttttcaaca cctgattcac gtaaatggtg tctgatttta agttgttcaa 914821 gaccttcaat tcagcgatgg acatattgac tttgtttgca attttccaaa gtgaatctcc 914881 aagctgcacc ttatatgttc ccgtagaaga tgaagaactt gaactcttat tagaactgct 914941 ttttgaactg gagcttgaac tcttattaga gttgcttttt ttactggaac tagagcttga 915001 agaaacagta ccggacacct ttaatttctg cccagcacga attaaatcgc tgcttagtcc 915061 gtttaatttt ttcagttcct gcaccgtcat tttaaactca tttgcgatca gccaaagtga 915121 atctccgctt ttcactgtgt aaacagaact tccgctcttc ttggttgttg agcttgaagt 915181 agatgaagaa gtgctggatt tgctgcctgg aatagtaagc gtctggccga tcgacagaac 915241 agtagtcgaa agatgattgg cggatgtgag ggccgccaca cttgtgttat aggtttgggc 915301 cagtttccat aaagaatctc cgcttttgac cttaatcgtt gctgcttcag ctggtgtcac 915361 tactaaagtt gtgccgacaa tcgcagatgc tgtcagccct gctgctaatt tctttttcat 915421 cttagctctc ctttttcccc caatgatttt gcatttgctg tttctttttt atatcggcac 915481 atttgtctca tcgttttgcc tttttataaa aatagccaaa ttatcttaac aataaggggg 915541 aaaaagggca taaaaaaaga aggaatctta atctattcct tcatttttaa aagcttcatg 915601 atatcttctt tgtttttgac gaggtcgcgc agtgtgtatt tgtctaaaac tgcgaggtag 915661 gctaaaagcg cttcattcag cacatgtttt aagccgcaaa ccggggaaat aacacagaga 915721 ttcttgttcg catcaaaaca ttcaacaata ttaaaatcgt cctccgtttt tctgacaacc 915781 tcaccgatgt tgatgtcttc agggtccatg cctaatcgta tgccgccgcc ccgtccgcgt 915841 atcgtttcta cgtagccgag ctggccgagc ctgtatatga ctttcatgag atgatttttt 915901 gaaatagaat acgtttcggc aatctgtttt atatttgaaa gttctccggg acgctctgca 915961 gccagaaaaa tcaacactct taatgaataa tctgtataat tggttaactt cataataaga 916021 cctcagaata agacattttc tatatcttat cataatcgat tgaaaaatga aaaaaaagga 916081 attaaaaaac atgcacccag ctgggtgcat gttttttgct tacatgtcat tcggcggatt 916141 ttggttttta cggttttttt cgatttctgt gttttgcatt ttgcgttcaa atgtagacag 916201 ataacgtgat gcaaaatcct taccgccaag gccgaaggat aaaccaaaag caagtgcgaa 916261 gccgctaaga acgatgatga acgcggaatt gacgattgtc gcagcgacac ccagctgatc 916321 cagggccata aagaaagcaa gtgcgataat cgtatattta gcaataggcg ctaaagactt 916381 gaattcctga ccttttatca tgcttgcgag cacttttctc accaattctc ctgcgtaaag 916441 gccgagtccg agaatgaata ctgcgacaag gacattcggc agatacgcga tgatgccggt 916501 ggcaatttct acgaggaagt gcagccgaac aatttgaagc gcctcagctg taaagagcag 916561 aatgacaatg atttgcgcaa tcataccgac aacttgagac aaggacagct ttgcaggcgt 916621 tccggcttcc atgcccattt tccctaagac agaatcaaag cctgcgcgat ggagcagtcc 916681 ggacaccatg gatttcaccc attttcctgc ccagataccc gctaatacaa gcacgatggc 916741 aatcatgatg ttcggaagca tgtttaaaat cgtattcagc atagagacag ctggttttga 916801 aatgccggcg acatccagct gatcaagcgc tgaaatgacc accggaatca taatgagcac 916861 ataagcgatt gttccgatga ctgctgaaag gcttgtgtct tttaagtaaa ttgataaacc 916921 catacgtgcc gcgaatcttt cggtgccgat gcttgcaagg aaattcgtaa tgatatcacg 916981 gacaaggcgg gcaacaagcc atccgattaa tacgataagc gccgctgcaa ataatttcgg 917041 cagaaaagcg agcacgcttt ccatcatatt tgtaaaagga cctgaaatgc cgctgatttt 917101 caaagaagat aagacccctg gcagaaaaac aagcagcacg agataaaaga caatttgtga 917161 agcggtattg acagcctggt gaatatcttt tccttcagac accaaattcc acttgcgcag 917221 tttgtcactc gtgttcagct tcatcccgat ttttttgaca aggaagctca aaacagaagc 917281 tgcagcccat cctaacagca gaatgagtcc ggctttcagc acgcttggga tcgcagctgc 917341 aatcgccgaa agcatactga caaacggcga tgccactgtt gtcaggtgca aaatgttaaa 917401 gaataaaata aagacgatga tcagtgcgat aaaataaacg accttgctta tgactttttc 917461 cgaggaatag cgtgaaggct ttttcccagc aaagagcttg tcgtcgattt ttgttttgct 917521 gagtcctttg tataccgctt tttcaatgat tttagcaata gcccagccga ttaataagac 917581 gagtaaagca atgattacgt ttggcagctt actgagataa gaagaaaaca cgtctgctac 917641 attcaattgg tatcgctcct ttttcgtagt atggtgtgtg tttacccact tatccaataa 917701 gcaaacagat gaatgtgccg ggggaatttt ttcttgcccg agtgagacta tcatcttttg 917761 tctggcgggc tcatacatta tagataagtc caagtagggg ggattcggtt gaacgcggag 917821 gagaagaagg gattacagcg ggcaattgag gaaattaccg aaattgcaaa aggattcggc 917881 cttgatttct acccgatgag atatgaaatc tgcccggctg aaattattta tacatttggc 917941 gcgtacggga tgccgacaag attcagccac tggagcttcg gcaagcagtt tcacaagatg 918001 aagctgcact atgatctagg gttaagtaag atctatgagc tggtcattaa ctcagatcca 918061 tgctacgctt ttttgctgga cagcaactca ctgatccaaa ataaattgat tgtcgcacac 918121 gttcttgctc attgcgattt cttcaaaaac aactgccgtt tccaaaacac gaagcgcgat 918181 atggtggaaa gcatggcggc aacagctgaa cggataaaac actatgaaca ggttcacggg 918241 ataaaagaag tcgaatcttt tttagatgca atcctttcga ttcaggagca tatcgatccg 918301 tcgttggtcc gaccaaagct ccaatggagt gtggatgatg aggaagagga gattgaagag 918361 gcagccacgc cttacgatga tctatggtct ttagatgaaa agaaaccgaa aaaacaagtg 918421 aaaaaatcga aaaaaccgtt cccgccgcgg cctgaaaaag atatcctgct ttttatcgag 918481 gagcattccc gggagctgga gccatggcag cgtgatatat taacgatgat gagagaggaa 918541 atgctttatt tctggcctca gctggaaacc aagattatga atgagggctg ggcttcctat 918601 tggcaccaga gaattatacg tgagcttgat ttaacctctg atgaagcgat cgagttcgcc 918661 aagctgaatg caggtgtcgt tcagccgtcc aaaacaggca ttaatcctta ttatttaggg 918721 ctgaaaatat ttgaagacat tgaaaagagg tacaacaacc cgacggagga aatgaagaaa 918781 atgggcgtgc agcctgactc cggccgggag aaaatgtttg aggtcaggga gattgaatcc 918841 gatatctctt tcatccgcaa ttatttaacc aaagaattag tcatgcgcga ggatctttat 918901 ttgtttcaaa aacagggccg agattataaa atcatcgata aacagtggaa gtcggtgcgc 918961 gaccagctcg taagcatgcg ggtaaatggc ggttttccat atttgacagt aaacgacggc 919021 gattatatga aaaataacga actctatatt aagcattggt atgagggcat agagttggat 919081 ttgaaatatt tggagaaagt gcttccttat ttattccagc tttggggaag aagcgtgcac 919141 attgagtctg tgcttgagga taaggaagtc atgttttcgt acgacggaaa aggtgttcac 919201 cgcagatatt tataaaaaag aggatgcagc gttctgcatc ctttttattt tccagttttt 919261 aaaatcttaa atatgatgtt tgcctggtcc gtattgttaa tcaatccgcg gaatttttct 919321 tttccggggc cgtacgcgta taccggtact tcttcgccgg tatgatcggt actcgtccat 919381 ccgctgttgg agcgggtatt aaaaatcttg atgatggctt tggaggcccc tttgcttttg 919441 tcagcctgtg cagctgcttc aacgcttttg atttcttcag atgtgacttt cagattggca 919501 tagcgggcga gcacatcttt aaccggcttg ccttcactga tttttttggc catgaattca 919561 ggtgttttct tagcggagag aatcggttct gcgtgccaat tcttttcccc gtttgcgcca 919621 atggtaaagc cgccggttgt atggtcagca gttgcaatca caagtgtatg tttgtctttt 919681 ttcgcaaatt caatcgcggc tttataggcc tgttcaaaat ctttaacctc gctcatggct 919741 cctactgtat cattgtcatg ggccgcccag tcaatctggc tcccttcgac catcaagaaa 919801 aatccttttt tattttggtt caggcgatca attgctgaaa ccgtcatgtc tttgagagac 919861 ggtgttttac tgtcacggtc gagcgcttta gcaagccctc catctgcgaa aagcccgagc 919921 acctgctgat ctttattttt tttcaatgct tgtttagttg tcacatagct gtagccggct 919981 tgtttgaatt cctttgtcaa gtttctgtcc ttgcggttaa aataagattt tccgccgccg 920041 agcagcacgt ctattttatg tttgcctttt atcttgtcat ccatatagct gttggcgatt 920101 tggtccatgt ttttccgtga ttcattgtgg gcgccatatg cggctggagt ggcgtggtta 920161 atttcagacg tggcgacaag ccctgttgac ttgccttgct gtttggcctc ttcaagtaca 920221 gatttcactt tttttccgtt tttatcgacg ccaattgcat tgttatatgt cttaacgcct 920281 gtcgctaatg ctgttccggc tgctgctgaa tctgtaatat tatagtcagg gtcatccgga 920341 tgcgtcatca tcatgcctgt caggttccgg tcaaattctg ttaacttcgg gttattcggt 920401 gtgtcaccgt tatttttcat ggaacggtag gctcttatgt aaggcgtccc catgccgtcg 920461 cctatcatca caatgacatt tctgatctca gctttgtctt gttttttggc gctggccttt 920521 tctgtttgct gaagctcagc tccggcaaag attccagctg taaggacaga aacagcggcg 920581 attggcagaa gttttgattt catattttga aacaaactca tttttttcat gcctccttta 920641 atgtattccg tttatcatgt tagggaaact ttgttaaatg cggctgttga tcatgtaaac 920701 aataagtaaa gccttgtaag gaaatgaaaa aacgcttttc gttatcttgc cttatttgat 920761 gtaaagcatt catttttcag aaaaatcttt acctctctgt ctttgcatga tatgtttgtt 920821 taaataaaaa aactgcggat aaccacagct ctcctcgaat atactttatc actcattttt 920881 ccgatatatg agccgacccc gaaagttttt catttatttc ctttatgttg aaaaacatcc 920941 cataaaacat gacaaaagca ctcgtttttt gtcacctttg caatgaaaat gaaatattta 921001 atacccttaa aaactttttt ttagaacgaa taattaagaa atttgtcaca tgaagtcaag 921061 actatttctg atgggaatct atccttataa tagaaatcaa taagattaat ttaaaaaaag 921121 agatacatat atatagagtt aacatttggg gaggaaaata tgaaaaagca aatcattaca 921181 gctacgacag cagttgtttt aggatcgacg ttatttgcag gagcggcatc tgcacaaagc 921241 attaaggtga aaaaaggcga cacgttatgg gatctttcaa gaaaatacga cacaacgatc 921301 agtaaaatta aatcagagaa ccaccttcgt tcagacatta tttatgtggg acaaacttta 921361 tcgattaacg gcaaatctac aagttcaaaa agcagcagtt cttcttcctc ttcttctaca 921421 tacaaagtaa agagcgggga cagcctttgg aaaatttcaa aaaaatacgg catgacaatc 921481 aatgaactga agaagctgaa tggcttaaaa tcagatttgc ttcgtgttgg acaagtcctg 921541 aaactgaaag gttcaactag ttcaagcagc tccagctcat caaaagtgtc atcgtcttca 921601 acttctactt ataaagtgaa gagcggagac agcctttcta aaattgcgag caaatacggc 921661 actacggtta gcaaattaaa aagcttaaac ggcttaaaat cagatgtaat ctatgtcaac 921721 caagtattga aggtgaaagg aacaagcaca agcagctcaa aacctgcttc atcttcatcg 921781 tcttcaagca gcaaaacgtc atctacatca cttaatgtga gcaagctggt ttctgatgca 921841 aaagcgttag tcggaacgcc atataaatgg ggcggaacga caacttcagg ctttgactgc 921901 agcggattca tttggtacgt actgaataaa caaacaagtg tgggcagaac aagcactgca 921961 ggatactgga gttctatgaa gagcattgcc agcccgtctg ttggtgattt cgtcttcttc 922021 acaacatata aatccggccc ttctcacatg gggatttaca ttggaaacaa cagtttcatt 922081 catgcaggat ctgacggcgt acaaatcagc agcctgaaca acagctactg gaagcctcgt 922141 tacctcggtg cgaaaagatt ctaattttta gagaaaaccc gttcattgga acgggttttt 922201 ttcattagac ggagcacagg cgttttggtt gctcctaaaa atgaaaatgt gataaaaaat 922261 ccaagaactt tttttctttc ttattttcat aaagggcaat cgcgtaagcg ccggcatagg 922321 gcagctgtac agactgataa ggaattctga tcatctgttt ctctgctaac tcacgcttta 922381 ctgtagataa aggcagaaat gaaactccga gtccttcctt gataaaccgt ttcgttatat 922441 gtgtttgagt gaccttcatt gttctcacaa atggaaatgt cattctgact tgacggagca 922501 agtcgtccca gtaatcagga tgattgtggg tcaaaagcag gtattgttcg agcacctctt 922561 tggcatcaat ttcgttgtct tctatgaaac gcttatcggg cggggcaaca aggacgacag 922621 ggtctttgta taagcagtgg cagcttaaag aagaagactg tacctttaaa cagcttagtc 922681 cgatatctgc ttccccggct ttaatcagtg acgcgatttc cgctgattcg aaaatcgtaa 922741 ccgccatttc tgtttccgta ttcattgctg tgtaccgctt catgacagaa ggaagcactg 922801 tatctgcaat aagcggagaa accgcgagct gtaaggtttg agagtagcct tgtctcactc 922861 tgtgaagctc tgccatgctg ttttcataat catcaagaag cctgagcgca tacggcaaat 922921 acgccctgcc ttcatcagtc agctggattt gcctgccttt acgctcgaac agcttgcagc 922981 tgatttcttt ttctaattgc ttgatatgta cggtcacagt aggctgagat aagaaaagcg 923041 tttccgccgt ttttcggaag ttctcatatt ttgcagcggt cacaaaggtg tgaagccatt 923101 tgaaatccat ttctattctc cctctgatta atatttttaa ttaattccct ttaaaatatt 923161 gattattttt taaatattat atttactata ataacagaaa aggatagggg gaatacaaat 923221 ggtacattac ggattaaagg gaattacatg tgtagaaaca tccatcagcc atattgatgg 923281 tgaaaaaggg cgtctgattt acagaggaca tcatgcaaaa gacatcgcac tgaatcacag 923341 ctttgaagaa gcggcttatt tgattttatt tggaaaactg ccttcaactg aagaattgca 923401 ggtatttaaa gataagctgg ctgcggaacg gaatcttccg gaacatattg agcgcttgat 923461 tcaatcactg ccaaacaaca tggacgatat gtcggtgctg agaacggttg tttcagcatt 923521 gggggaaaat acgtacacat tccatccgaa aacagaggaa gcaatccggc tgattgcaat 923581 cacgccttct atcattgcat acagaaaaag atggacgcgc ggtgaacaag caattgcacc 923641 ttcttcccag tacggacatg tcgaaaacta ctattatatg ctcacaggtg aacagccttc 923701 agaggcaaaa aagaaagcgc ttgaaaccta tatgattctg gccacggagc acggcatgaa 923761 cgcatcgact ttttcggcac gagtcacgtt atctacagag agtgatttag tgtcagccgt 923821 cacggctgct ctcggtacga tgaaaggtcc gctgcacgga ggtgctcctt ctgcggtgac 923881 aaaaatgctt gaagacattg gagaaaagga acatgctgaa gcatatctga aagaaaaact 923941 cgaaaaagga gagcgcttga tgggattcgg ccacagggtg tacaaaacaa aagacccgcg 924001 ggcagaagct ttgagacaga aagcagaaga ggtggccggc aatgaccgtg atcttgatct 924061 tgcgctgcat gtagaagcag aagcgattcg tttgctagaa atctacaaac cgggacgaaa 924121 gctgtacaca aatgttgaat tttacgcagc tgcagtgatg agggccatcg attttgacga 924181 tgaattgttt actccgacct tttcagcaag ccgaatggta gggtggtgcg cccatgtact 924241 ggaacaggca gaaaacaaca tgattttccg cccgtcagcg caatataccg gtgccattcc 924301 cgaggaagtt ctttcataac atattttggc gtttattcat ttctgtcgtg tggtaacgtt 924361 cagtatcaac cacatgtcta ggagtgatga atgtgaaccc aatggacaga caaacagaag 924421 gacaagaacc gcagcatcag gacagacagc cgggcattga gtcaaaaatg aatccgctgc 924481 cgctgtcaga ggacgaggat tatcgaggaa gcggaaaact gaaaggaaaa gttgcgatca 924541 ttactggagg cgacagcgga atagggagag cagcagctat tgcctttgct aaagaggggg 924601 ctgatatctc cattctatac ttagacgagc attcggacgc agaggaaaca cgcaaacgga 924661 tcgaaaagga gaatgtccgc tgcctgctta tcccgggaga tgttggggac gagaaccatt 924721 gtgaacaagc tgtgcagcaa acagtggacc attttggtaa actcgatatc ttagtgaaca 924781 acgccgctga acagcatccc caggacagca ttctcaatat ttcaacagaa cagctggaaa 924841 aaacctttcg cacaaatatt ttttccatgt ttcatatgac gaagaaagct ttgcctcacc 924901 tgcaagaggg gtgtgccatt attaatacga catcgattac cgcttatgaa ggggatacgg 924961 cgttaattga ttattccagc acaaagggtg cgattgtttc ctttacgcgt tccatggcga 925021 agtcgcttgc agataaaggc atcagagtga atgcggtggc gcccggtccg atttggacac 925081 cgcttattcc ggcgacattc cctgaggaaa aagtgaaaca gcacggcttg gataccccaa 925141 tgggaagacc gggacagccg gttgagcatg caggcgccta tgttctgctg gcgtctgacg 925201 aatcttccta tatgacaggg cagaccattc atgtgaatgg cggccgtttt atttcaacgt 925261 aatcaacgaa aaaccagctc aagagctggt tttttgtgtg gtgaaaaatt tcaaaataaa 925321 aaatttgtcg atttttctaa caattttgtt ttcatttttg caattttata tataatattg 925381 agtaggagaa aggaatgatt cgcgaccagt acaaatatag tagaaaaaaa agaataatga 925441 ccattgttac tcatgaattc agaaaattca aataaaatat ataaaaatag atgatcggga 925501 gttgaagggg aatgaaaggg agcgttttta ggaagaaaag cattcaggat ttaatcgctg 925561 cgacgagcgg ggaaaagtct ttaaaaagag aattaggggc atttgattta acgttgcttg 925621 gaatcggcgc cattattggc acagggattt ttgttctgac gggaacaggc gcagtcacgg 925681 ccggtcccgg gctgacgatt tcatttgttg tggcggcgtt ggcttgttta ttcgccgccc 925741 tgtcttacgc ggaatttgcg tcaagtgtgc ctgtttcagg ttcggtgtat acattcactt 925801 atgcgacatt gggagagctt atggccttta ttatcgggtg ggatttaatt ttagaataca 925861 tgctggcggt aagtgcagtg tcggtcggct ggtctggtta tttccaatcg tttttatcag 925921 ggcttggcat tcatcttccg gttgctttaa cagcggcacc gggcgcagtg aaaggcacct 925981 ttaccctgtt taatcttcct gcattcgtca ttgtaatggc gatcacatat ttgctttatt 926041 taggcatcaa agaatcaaaa agagtcaaca atatcatggt tatcttgaag atactggttg 926101 ttctgctgtt tatcgcggtg gcagccgttt acgtgaagcc gcacaactgg cagccgttta 926161 tgccaatggg ctttggcggc gtgttcagtg cagcggcgct cgtattcttt gcttttatcg 926221 gatttgacgc tgtatcctct gctgcggaag aaacgaaaaa tcccgcgaag gatctgccta 926281 aaggcattat tttctcttta ctggtctgca cgattttata tgtcaccgta tcagccatca 926341 tgactggggt tatcccgttt gctcaatttg cgggtgtgga tcatccggtt tctcttgttc 926401 ttcaaagcgc agggcaaaat tgggtggcag gcatcattga tattggcgcc gtgttgggaa 926461 tgacaacagt tatgctcgtg atgctttacg ggcagacccg cgtcatgttt gccatgtcgc 926521 gtgacggact tgtgccgggt tcactttcta aagtgcatcc aaagcacaaa acaccttatg 926581 tagccacttg gtttttcgga acgatgtcgg cgcttctcgg ctcacttgtt ccgctggatg 926641 aacttgcaaa gctggtgaac atcgggacgt tgtcggcatt tgtcctgatt tctgtggcag 926701 ttatcgtttt gagaaagaaa cagcctgatc ttccgagagc ttttaaatgc ccgggagttc 926761 ccgtgatccc aggcctggcg attctgttct gcctgttctt gattttaaat ctgggatggg 926821 tgacgattgt ccgcttccta gtgtggctgt taatcggctt ggtaatctat ttcctgtatt 926881 caagaaagca ttcaaaatta aatcaataac cttttgataa agagagcggc catacaggcc 926941 gcctcttttc tgttcttggc aaatgaatct atagaaatga agacaaaaat aagagataat 927001 ataggctgga aaggaagtga cgtttattgt ctgagcaaaa accagtccaa tgggcttcga 927061 aaattggttt cgtcatggca gcggccggct cggctatcgg cttgggcgcg atttggaagt 927121 tcccttacgt agcggggacc aatgggggag gagccttttt tcttatcttc gtgttattta 927181 ccatcctctt aggctatccg cttttggtgg gggaatttat ttttggaaga cggaaccaga 927241 cgaatgccat tgatgcatat aaaaaagaag cgccgcgatc agcttggttt cttacggggt 927301 ggatcggcgt agcggcgtgt ttcttagtgc tgtcgtttta cagtgtaatc gggggatgga 927361 ttttgctgta tatcgtgaaa acagcgtcag gatcactgtc cgggctttct caagcacagt 927421 atggcgctct ttttgcttct attatccaaa atccggtgca gacgctcgcg gctcagcttg 927481 tctttatggc actgactgta ctcgttgtcg caagaggggt tcaaaaaggg attgaacggg 927541 taagcgcggt gatgatgccg attttgtttt tattgtttat tctgctcgtt cttcggtctc 927601 ttacgcttaa tggtgcaatg gaaggcgtaa agtttctgct tgtgcctcat ttcggcgatc 927661 tgactccgga atccatatta ttcgcgctgg gacaggcctt ctttacgtta acactggggg 927721 tttcggtgat ggtgacctac agctcctatt tgccgaaaac acaaaatatc cctcgttcgg 927781 cagcctccat tgtcttgatg aatatcattg tgacactctt ggcaggtttg gctatttttc 927841 cggcggtttt ctcattcggt tttcagccaa atgaaggacc gacattgctg tttacagtgc 927901 ttccggccgt ttttgaacag cttccgttcg gcacattgtt ttttatcggc tttctcgttg 927961 catttttatt tgcagcctta acctcagcat tttcgatggt tgaaattatc gttgccacaa 928021 tcggaaaagg ggacgaaaag aagagaaaaa aactgtcatg gacgagcggg cttttgatct 928081 ttttggtcgg aatcccatgc tgcttgtctt atggcgtttt gagtgatgtg cacctatttg 928141 gcaaaacgtt ttttgatatt gccgatttta ccgtcagcaa tgttttgatg ccttcaggcg 928201 ctctgttaat ttctctattt atcccgctga aaatttcgaa aagcgaactc ttggctgaaa 928261 tgcgaaatgg atcaaatgca ggtaaagcat tcttttacac atggttttat ttgcttcgtt 928321 ttatcgtgcc gcttgccatt attatcgtgt tcttaaattt aatcggaatt ttatcatttt 928381 aaaaaacagg ctccgtttcc ggggcctgtt ttttatttaa taagatgata tcaacggtgc 928441 ccatgccgtt ttcagttttt ggatgccgag cctgatgtcc tcttctgaca aaccgccata 928501 accgattaag acagaagtaa aaggcgtctg ttctatatat gagggagaca cgggatagag 928561 ggttacaccg tggtcagcgg ctgcttgtat tgcttcttcc tcacttgctg gaaacaaaag 928621 gcgcagcaga atgtgaagcc ccgagttctt accgagaatc tcaacggtgt ttcccagttc 928681 agagcgaatg gcttctaaca ggacagcgtg tttttttcgg tataagcttc tcattctatt 928741 tatgtgtttt tgccactctc cggtttcgat gaagtctgcc agtgccaatt gcgagtgggc 928801 agaaacggtc tgcttcatta actgaacatt gttttggatc ggttccatga gttcaggggg 928861 cacaatcatg aagctgagcc gcaaggaagg cagaagtgac tttgaaaaag tgcccagata 928921 tatgactctg ccattcggat caagaccctg taaagacgga atgggatggc cgctgtagcg 928981 aaattctcca tcgtaatcat cttctataat gaatgaattt gtttctgccg cccatgccag 929041 cagctcctgt ctgcgggtaa tcgtcataat ggtcccaatc ggaaactgat gcgaaggagt 929101 cgtatacatg agataaggat tctgacggta gagctcatcc ggcaggacgc cttctgcatc 929161 agaacaaatc ggagtgacat ccatgtgatt tgcttcaaac atccttcttg aacggtgaaa 929221 gcccggttct tcaaagccga tttttgtacc tggctttagc gaaaggcaaa gattttgcag 929281 aagcacggtg gttcctgcgc cgatgataat ctggccgggt tcacaattta ctccccgaga 929341 cagcctgacg aatcgggcaa tcatgtgcct gagttcgtat tctccttgag ggtcgccaga 929401 ggtgtgaaac gatccggaat agcgatcaag actttttact atgctttttc tccatgcgtt 929461 aaagggaaag agggtcggat caacgctgcc ctgatggaag tcaatagcag gtgcgttttt 929521 ttgatgtaat cccggctgta cagactgctg aaaatggtca ggagctgtcg ggaatcctgg 929581 ttctacttcc gccgcgaacc agccgatttt cggcttgctt ttgacatagc cctcagcagt 929641 taattgctca taagctcgtt ctatagttgc cgtgctgaca tcgagcaagc tggagagcct 929701 gcgttttgac ggaagtcttg ttccctttgt gattcgcgca tgtgaaattt cttgtttaaa 929761 aaaggtataa agctgttcat acagcggtgt tttgctcttt ttatcaagaa acggcgtaat 929821 atccatctca tgtctccttt gtagctggca tggtcatttt ttctgatatt ggctatttgg 929881 caaatgccat ttattagcta tgatcattgt aacgaaagga aaggggattg agaagatgat 929941 ccatatgaaa caattaacct cgaaagaaga atgggctgag tcgtatccga ttatgagtga 930001 attgagaaca gaactggata tagagacgta tttacaaagg cttgaagcct gtgtgcagaa 930061 agaatcgtat atgctgtttg ccttatatga aaatacagca atcagagcgc tgtgcggggc 930121 tctgccgaga gtttccattc ataaaggaga gcacttgtgg attgcggatc ttgttacaac 930181 ggcaccttgc cgatcaaagg gatacggcaa aatgcttttg gattatgcct cagactgggc 930241 gagaaaagcc ggactcggtt ttgtcagtct ttcatctggc cttcagcgta aagacgcaca 930301 tcgattttat acagataaaa tgggttttac tatagaaagt tatttgttcc gaaaaccggt 930361 ataacgaaaa aagacgcctg aaaaggcgtc ttttttaaaa gccaaactgt aaattcgtat 930421 ctacagatac aatggtatac acacaaataa tcacaaagag attaaggatg acgccgagca 930481 ggcctggacc tgtgcgccct ctcttgatga agagttcaac aacgccgaac ggaacggcag 930541 ccatggcgaa cggaagcatt tgataggaat aaaacgtgac gttgctgata atggccaaat 930601 tcagcaacag cagggacaga accgctgtcc cgacagagat ccagccgaat acattgtgtt 930661 ctttaaaaat tcttaccagt tccataattc cacctcgccg acattcgctg attttacaga 930721 tttatttttc agcatgcgct ggatttcctt ggttggccct gtaacgaccg aaccgtatac 930781 attgacaccg tttttctcta cataatctaa tcggttatct acattcaggt ctttccgttt 930841 tgaaatgacc tgagcccatt tttcgtgttt ggacatgaat ttcagggcgt tgataaactg 930901 atcgccattc gacttgcctt ttgtattaag ggcggccaag aactttgaat cctttccagg 930961 atagccaaga ggttctgtgg aagctgtctt atttgtgttt ttctctgttt cgattgcgtt 931021 ccacaaaaag ctcacatcat agcctttgaa tttgttatac acgtcttttg tcggatatgc 931081 acggtcatat gaaaggtaga cctctgatac cgttccttca ggcaatgtgc ttaacgtttt 931141 ttctgctttt gcggtcgttt gttcagactt gtttgaagga tgtgtaaagt aatggccggt 931201 tttattcact tctaagtcat agtagtttac tgccggcgct tttactttgt tataaaacat 931261 ttcaacccgt tcattcccta cggcagccgt cttcgtgcca atctgctttt gcagcgggaa 931321 ttccgtattc attccaaata gcttcacttg gcttttcagt ccggaagtat caacaagaac 931381 attcggcatg gtcagggcta cagtgactgc ggcagtttcc ataaactcat tgccggtgct 931441 gtgttttcca cccattccgt aatagaggta gcttcccagc gtacaaagcg gcaaaatcat 931501 caatgtcgaa atgacggcaa gcacagaaat tcgcaaataa gacttgcgtt tgccgtaggc 931561 taaaatcgct ttttgttttt caggactgat gctgagatcc caatcgttat cgtcctctag 931621 ttcgctgtca atcagttcct gatatacttc aagcttctcg agttcttcct caaatgcagt 931681 catttcctgg tcgctcattt ccccattttt atattgatca aaacgctttt taaattcttc 931741 attcatcatt aacacctcta ttataaagtg ctttcagccg ctgtctggca cgaaataaaa 931801 cacttttaaa attcgcctct gaaatattca taatatggga tgcttctttg tagtttaact 931861 cttttaaata atatagcgtt aaggcctccc gataattatc ggggagctcg gacatataac 931921 cagtcagcac ttcctttatc tctacctgat gggcaggact ttgaacagca ttttgaaaga 931981 ggcttccgat taagtcatca gaaatggtta cttctttctt atgctttctg acgtaatcaa 932041 tgaaggcgtt tcgcgccact tgaaaaagcc agggctttac tttgctgtga tcataggagt 932101 gaatgtgtat gtatgcccgc ataaaggttt cctgcagtaa gtcttcagca agatgcttgt 932161 cttttgtcat ggagagcagg aacctgtaaa catcattcat gtacatttgg taaatttcat 932221 cgatcgtcac tgccttttct cccctctatg ttatacacgc ataagaaagg tttaaagttg 932281 cacattacat gcaaacggct tttttatacc taatcaaaca ccattactat atagtaccca 932341 aaaatggccg caaaagatag tgcggagaaa ggtttaacat tttttccaga ggggaaaaga 932401 tagtgaaaaa gtgaaggagt ggcacaatgg aatataccag tatagcagat acaggaatag 932461 aagcctccag aatcggcctc ggcacatggg ccattggcgg aacgatgtgg ggaggcactg 932521 acgaaaaaac atcgattgaa acaatccgcg ccgctcttga tcaggggatt acactgattg 932581 acaccgcacc ggcttacggc ttcgggcagt ccgaggaaat tgtcggaaag gcaatcaaag 932641 agtacggcaa aagagaccag gtgattctcg caacgaaaac ggctctggac tggaagaaca 932701 accagctgtt ccgccatgcg aacagagcga gaattgtaga ggaagttgag aattctttga 932761 agcggcttca aacagactat attgatcttt atcaggtgca ttggcccgat ccgcttgtgc 932821 caattgaaga aacggctgaa gtcatgaagg aattatatga tgcgggaaaa atccgggcga 932881 ttggcgtcag caatttttca attgagcaaa tggatacatt tcgcgccgtc gcacctctcc 932941 atacgattca gcctccatat aatctgtttg aaagagagat ggaagagagt gtccttcctt 933001 atgcgaaaga taacaagata acaacattat tatacggcag tttatgcaga gggctgttaa 933061 caggcaaaat gactgaagaa tatacatttg agggcgatga tctgcgtaat cacgatccaa 933121 aattccagaa gccccgcttt aaagagtatc tttctgctgt gaatcaattg gataagctgg 933181 cgaagacacg ttatggaaaa tcagtgattc acttggctgt cagatggatc ttagatcagc 933241 cgggagcgga tatcgctctt tggggagcaa gaaagcctgg gcagcttgag gccctatctg 933301 agattacagg ctggacgctg aacagtgaag atcagaaaga tatcaatact atattggaaa 933361 atacgatatc agaccctgtc ggaccggagt ttatggcccc gccgaccaga gaggaaatat 933421 aacaaaagct gagggcgaat cctcagcttt ttggcgttta aacgagagaa atcttaaaaa 933481 ttagtaccag gtaataaaaa atattgttat aatagatgac agaaagaatc attgattacg 933541 acaaaggaag tgcgatatgt ataagttttg tgcaaatgct ttaaaagtta ttctttctct 933601 tcgcggagga gtgaaggtgt ataacaaaga aaaccttccg gccgattcag gttttgtcat 933661 cgcgtgtaca cattccggct gggttgatgt gattacactc ggagtcggga ttcttcctta 933721 tcaaatacac tacatggcga aaaaagagct ttttcaaaat aaatggatcg gttcgtttct 933781 gaagaaaatt catgcctttc cggtagatcg ggaaaatccc gggccaagca gtattaaaac 933841 gccgattaag ctgctgaaag aaggagagat cgtcggtatc ttcccaagcg gaacaagaac 933901 ctctgaggat gtgcctttga aaagaggtgc ggtgacgatt gcgcaaatgg ggaaagcgcc 933961 gcttgtcccc gctgcatatc agggcccttc aagcggaaaa gaattattca aaaaaggaaa 934021 aatgaagctg attatcggtg agcctcttca ccaggctgat tttgcccacc tgccttcaaa 934081 ggaaagactt gcagcaatga cagaggcttt gaatcagcgg attaaagaac tagagaataa 934141 acttgatcag ctataaggcg ttctgagaga ttgtcctgaa actgtgaaaa taagaaaagc 934201 accctataca aggtgctttt cttattatgc ttcctgctgg ttagctgtct ccagaagttc 934261 ttcttcttga agctttttca cttcaatata tgcgacgtgg tggccgtcaa tttcattaat 934321 gatgaattcg cagccctctt cgatgatgga atcatctttt tcaacatcgt atttttgagt 934381 aaggaaccag ccgccgattg tatcgacttc ttcgttctct aaatggatgc ctagcaggtc 934441 gtttacttgg tcaattaaca cttttccgtc aagaatataa tggccttcgc cgattttgcg 934501 gatttcgcta atttcatcaa tatcaaattc gtcgcggatt tcaccgacaa tttcctcaat 934561 gatgtcctca accgtcacaa gcccggcagt accgccgtat tcatcagaca aaatggccat 934621 gtggaccctc tctttttgca ttttgacaag caggtcttgg atcggcgcag attcaatgac 934681 atgaatgata gggttgacga attgagaaat ggtggaatca acagatacct caccgctgat 934741 gcaggcggtc agcacttctt taatgttaat aaccccgata atgttatctt tatcgccctc 934801 ttccacaggg tagcgggtat atttttcaat ctgaatgatg tccatcattt cagaaatctt 934861 gatatcatgc ggaaggctga caatttcggt ccgcggaatc ataatttctt tcgcgagcct 934921 gtcgtcaaat tcaaagattt tattcacata tttaaactct gattggttga tttcaccgct 934981 tttatagctt tcagacaaaa tgattcgcag ctcttcttct gagtgagcca gttcgttttc 935041 tgaaacggtc tccaggccaa atgctttggt caataaccgt gcggaattgt tcaaaagcca 935101 aatgaatggg aacgcgatgc ggtaaaacca aatcagcggt ttcgcaaaca gcatagacac 935161 tgcttccgcc ttttggatag cgactgtttt aggtgcaagt tctccgacaa caacgtgtaa 935221 gaacgtgata atggcatacg caaaaataaa cgatatgaca tgtgaaaggg aacctggaac 935281 gttcatttgg acgaaaagcg ggtgaagcag cctttcgatc gttgattcac ctaaaacccc 935341 taatccgatg gaagtcaatg taattccgag ctgacacgca gataaatatt catcaagatg 935401 cgtggtcact ttttttacgg ctattgctgc tttatttcct tccgcgatca gctgatcgat 935461 ccgtgagcct ctgattctga taatggcaaa ctcagatgcc acgaaaaatg ccgtcagggc 935521 gattaaaaca gcaactaaaa tcaaattcac tatgtccaat tagaaccttc actctagcaa 935581 tgagaatgaa ggtaacacct cctgttagat aaaatggttt taacttaaca gcagcataaa 935641 tgattggaac acggcgagct tttcaggcgg gagtttgctt ttcagcttgt cacgatcctc 935701 gggcttcagc cgttcaaacc gatgcaagat tccggagatg ttttgattca tatgatcaat 935761 ttctaatgcc agatttccaa tttcatcatc aagtttagct gaagagggaa actggttctc 935821 cagtcgatct ttaatatcgg acagggccaa tcgctgcttc ttgcaatcta caataaatat 935881 aagtcgtttg agtgcatttt cgtcgtagta acggtaattt gaacaggatc tggccggcgt 935941 aagcagaccg agattcgtat aataatcaac tgtccgtttc gttactccgg cgagtgccgc 936001 tagttcactg atgcgataag tctcagcccc atctatatcc ctcccaacca tcacgttata 936061 gttatgagaa tagtttaata tatgaacggt gtcttgcaca agtttattgt tttttttaga 936121 ccggaattgg aagttgtgga attcatcatc tgattgaagt aacataggaa gatagaattt 936181 tcaaattttt atatgcggaa gggacagatg aaattggctg ggttatcccg ggaagttgaa 936241 gaaaacttaa ataaaggatc atggattcgc aagctgtttg atgaaggtgc aaggctgaag 936301 aaggagttcg gggaagacca ggtatttgat ttttcactcg gcaacccgat tgttgaaccg 936361 cctgaagctt ttaagagagc gttaatagag gaagctgaaa aaggcagcca cggatacata 936421 caaaaccaag ggcttcttgc agcgagagaa aaagtcgcgc aatttctggg ctcgcgtttt 936481 gaagctgatt tctcagcgga gcgcatcgtc atgacggtgg gcgcgggagg cgctttgaat 936541 gttgcgttaa aaagcatcgt aaaccctggg gaagaggtca ttattcttgc accttatttt 936601 gccgaatata agttgtatat tgagaactac gggggaaaag ccgtcagctg cccgttgaca 936661 agccggtttg agatcgacat tgaagcggta aggcaatcga tcactccaca gacgaaaggg 936721 ctgattctca atacaccgca taaccccaca ggcactgttc tcagccagaa aaatatagac 936781 gatttaggcg ctttattaaa agaaatagaa gagaagagcg gccagacgat ttatgtgctg 936841 tttgatgaac cgtacagtca attaatctat gatgaagagc tggcaaatcc gtttcaatcg 936901 taccatcgtg tgatattggc cagctcattc agtaaagatc tcggcatagc cggagagcgg 936961 ctcgggtata tcggattgga cagccgaatg ccggatgcgg accttttgat caacgctttt 937021 gtgtattgta atcgaacgct tggatttgtg aatgcccctg tcatgatgca gcgggctgtg 937081 gcacgaatgg atgatttaag agtagacgcg agcgcttata aagagcgccg ggatttaatg 937141 gtagacattt taaaagaagc cggttttgaa tttgaaatgc caaagggagg tttctttgtt 937201 tttccgaaat cgccgattga agatgaagtt gcattttgcg tgcatgccgc ccaaaaatac 937261 aaattattaa ttgtgccgag cagcggtttt ggaatgagcg ggcatttccg attatccttc 937321 agtgtgccga tcgagcagat taaaaactca cgggacattt tcatttcttt atataaagat 937381 tttgcttaag aaggcaaaga aaagaaaaca gttttcaagg ctgttttctt tttatatccg 937441 caaaatcctt cctcttccaa tccagacagg cgcagaattg acaagcaggc atgcagttaa 937501 ggctttcttc atgataaaag tctaaaaatt aaaaatcatt tttggaatga gttgtgttac 937561 aataaaatat acaatttata atcaaacttt gacttttgga ggtggtatga tggggccctc 937621 tgcttaggca acaatacacc gcgtacctca atgttaagga aaaatgatta tatcaggagg 937681 tgactcctta tcctttgttg agaggatagg gttaaatgga cgatattgac agtctgattt 937741 taattggcgt gctcattgct ttaaccgcgt ttttcgttgc aagcgagttt gcgattgtta 937801 gagtgaggag atccagaata gatcagctta tcacagaagg aaacaaacgg gcgatactcg 937861 caaggcgtgt cattacagat ttggatgaat atttatccgc atcccagcta ggcattacat 937921 tgacatcaat cgggcttggc gtactgggtg agccggcctt tgaacggctg ctgcatccac 937981 tgtttgaacc gctcggcttg ccggactcgg tttcacatgc agtctctttt gcagtcgcgt 938041 acggcttgat cacgttcctg cacgttgttg taggtgaact ggccccgaaa acggtcgcga 938101 ttcaaaaggc agaacagctg actttactga tagcgggccc tttgcgttta ttctatttgc 938161 tcctgtttcc gtttatttgg atcctcaatg gatcggcgcg gcttttatgc gggatgttcg 938221 gtttgaagcc tgcgtcagaa catgatggtt cccattctga ggaagaactc aggatgctgt 938281 tatctgagag tttaaaaaac ggagagatta atccgtctga atataaatat gtgaataaga 938341 tttttgaatt tgataatcgg atcgccaaag aaattatgat accgcggaag gaaatggctg 938401 ctgtgtcaac tgagatgacg atggccgaga tgcttgaagt catgctgaag gaaaaataca 938461 cgcgctggcc agtcacagat ggagacaaag acagtgtgct cggtttggtc aatacgaagc 938521 atttgttttc tgatttgctg tttatgacag aagaagaacg aatgaagatg acgatccatc 938581 cgtatgtgag gccggtcatc gaagtgattg aaacgatccc ggttcatgac ttgctgatta 938641 aaatgcagcg cgagcgcatt catatggcta tattgtcgga tgaatacgga ggaacctcgg 938701 gacttgtgac gacagaggat attcttgagg aaattgtcgg agagatccga gatgaatttg 938761 atgaagatga acagccgctg atccaaaagc ttggcgacgg ccattatgtg atggatggaa 938821 aggttcggat cgatcaggtg aacagccttc ttggcgcatc gattcaagaa gacgtcgata 938881 cgatcggcgg gctgatatta aaagaaaaca tcgatattga ggctggtgaa tccattcgca 938941 tcggttcata tacgataaag gtgctgaaga tggacggccg attaatcaag caaatcgata 939001 taaaagaaga agccggcaac acaaccggga ttacggcgca ccacaagctg ccgctgcccg 939061 agcctgtgat gctgaacagt gcaaccttga gcgagaaata agctcaaggt ttttttatat 939121 tgtgattgtc cagccgcacc aaaatgcaaa aagcgacccg caaagtgtca ggacgatgta 939181 caagatgctt tcttttacac gtttggccat aaggagttga atagtttcaa cgctgaatgt 939241 ggaaaaggtc gtaaaggcgc caaaaaaccc cgtgccaatg ataagcgaga ccgaagcatt 939301 tgcaacgtga agtcctgtaa atattccgag cccgagagct ccgagaatat tgactgtcag 939361 tatgccaatg ggcaggctga gacctttggt tttggcggtt atgacattgc caagccagaa 939421 gcgaagcatt gcgccaagtc cgccccctat gaaaataccc gctagtgtca tttttcctgc 939481 agcccctttc tttgctgaat gcctgctatg cgccgtccca caaaaacacc aatcagtgca 939541 aatatgatcc ctgatatcaa tgaggctgcc acatataaaa gagccaatga gggttgtcct 939601 tgcaaaagca tcactgtttc cttagaaaac gtggacattg ttgtgaagcc tccgcaaaag 939661 ccggtgccta aaaaagccga cagcagaggc cgttttgccc cgatcataaa aaatccggtc 939721 aaaatgccta atagaaggct gcctgccgca ttttccagcc aggttgccgc cgggaactga 939781 ccggtgtgta tccataagtt taatccgtat cggaggcagg cgccaagcgc gcctccgata 939841 aaaaccgcgc tatatatttt catgtttgcc atcctttatg atgaaatccg ggtaatctgt 939901 aacgatgccg tccacgccca tggcttgtaa ttttgccgct gtcttttgat tgttgacagt 939961 ccatgcaaat atgtttaagc catttttatt gatggagccg atcatcagac ggttaagccg 940021 tgtgtgtttt atattgacat agtttgcaaa agagcggaag gccttcatct gatttctgga 940081 cagcatgcca aagttgggcc ttgtaatgac cgctgtcgga atcgaaggat aaagctcgcg 940141 gaacctttgg acggagcgga actgaaagga ttgaacaata ttattgatag aaaaagaaaa 940201 ttgccctaat agctgtccca cctcttcttc aattccgact tgagacggat ggccttttag 940261 ttcaattaaa aggccgattt ttttgtggta gcgcttgagc accgcttcca gggttggaat 940321 acgctctcct tgaaaagcgg gaccgtacca gcttcctgca tcgagttttt gcaattcctc 940381 caaggtaaaa tccttaacaa agcccgatcc gtttgttgtt cggtcaaccc tgtcatcgtg 940441 tatcacaaca atctgcctgt cttttgtaag ctggacatcc agttcgatca tatctgcatt 940501 cattttcacc gcaaggtcaa atgcggcaat cgtattttcc ggagcgtagc cggatgctcc 940561 gcgatgggca atgatgtaca agctaagtca gctcctcgta tgggcatttc tgttattgta 940621 tcaaatccat atatgcaccg cgatacaaac tggtgaattt tttctgccat atcggaatgg 940681 tccgggctga ggaatgcgta taactaaaaa aagacactca gcgtatcaga acacatttcg 940741 tcagaaaatt aggtctttcg acatgttcac aacaaaatat gatcctttat aatagcaaaa 940801 aaggaggcga gatcatggga aaagggagaa tcagagtgga ggaaagaatt aaagccgaaa 940861 cggatgctga aatgcaaaaa gcaactctcc ttgatcagac acaaacgaaa aaaggtaagt 940921 gactgtccct attgaatctg gctgatagat gaattgagaa atgaccccgg cgtttcgccg 940981 gggttttgtg ctgcataaga catttaaatg aacatcctta cgaatatttt agtataataa 941041 acaattgatt gggatagagg ggagacagtc atgccggatt atctgcagca gtattttacg 941101 cttgataaca tcatacaaat cggcatcagc ttggcgattt tgctggtgtt tcttatactt 941161 agaaaattat tcacaagata tttttttaac ctgcttttta atttgacaaa ccggccgaaa 941221 acagaaattt ttaaacaggt ggttctggcg tttgataagc cggccagatg gttttttgtt 941281 gcccttgggc tgtttttagc gatccggtat tcaccgtttt tagatgagca aatgccggtc 941341 atcagcaaaa tataccgctc actgattgtg gcgctcttgt gttggggtct ttgtaatttg 941401 accgcaacat cgtcgtttat cttccataag gtgaaccagc gcttcgagct tgacatggat 941461 gacattctgg ccccgttttt atccaaattg ctccgttttg tgatcattgc gctcagtgtc 941521 agtgtgatcg ctcaggaatt caattatgat gtcaacggat ttgtagcggg ccttggtctt 941581 ggcggactgg cttttgcgct tgccgcgaag gataccatca gcaacttctt cggcggtatt 941641 atcattatta ctgaaaagcc gtttacaatt ggtgactggg tggagacgtc gacagtaaca 941701 ggatcagtcg aggatattac ctttaggagc acgagattca gaacagcaca gggggcgctt 941761 gtaacggtgc cgaactctac gctgtcgatg gaagcgatca cgaactggac aagaatgacc 941821 aaacgccaga ttacgttttc catccatgtg tcctacgcta cgccgattga gaaccttgaa 941881 cgctccattc attctctcag aacaatgctc ttagagcatg agggcgttga taatgaaata 941941 atcatggtca actttgatac gtttgccgac agctactaca atttattttt taacttctat 942001 acaaaaacga cggtttgggc tgaaaacctt aatattagag aggatatcaa ctataaaatt 942061 attgagattt taggtgcaga aggcgttcag tttgcatatc ccggccaaat ggttgttgtc 942121 aagcaaaagc acgaaagcga ccaattccag gtgaatctaa ataaagagga aaaggaacgg 942181 gcttaaaaga gagacttcgt ctgacagagg cggagtcttt ttcatggtaa aataagagaa 942241 aaaggcggtg ttgagttgga aacattcaaa agtattctac atgaagcaca gagaattgtt 942301 gtgctgaccg gagcgggaat gagcacagaa tcagggatcc ccgactttcg ttcagcaggg 942361 ggcatttgga cggaggatgc ctcaagaatg gaagcgatga gccttgatta ttttttaagt 942421 tatccgcgtc tgttttggcc caaattcaaa gaattgttcc agatgaaaat gagcggcagc 942481 tttgaaccga atgaaggcca tttgctttta gctgagctgg agaagcaagg gaagcaggtc 942541 gatattttca cgcaaaacat tgacggtctt cataaaaaag cggggagcag gcatgtgtac 942601 gaactgcatg gttctatcca gacagcagct tgtccggcat gcggcgcccg atatgatctt 942661 ccccatttgc tggagcggga ggtgccggag tgcacggcgg ccggaaacaa tggggacatt 942721 tgcggaacgg tattaaaaac cgatgttgtt ctctttggcg atgccgtcat gcactttgac 942781 accctttatg aaaagctgga tcaagcagat cttttattgg ttatcggcac gtctctcgaa 942841 gtggctccgg ctagatttgt gcctgaggat gcaagcctga ttcccggcat gaagaaagtc 942901 atcataaacc ttgaaccaac gtattgcgac agcttgtttg acatggtcat ccatcaaaaa 942961 atcggcgagt ttgcccgaag tttgggcatg aaaaagtgag ccgctttatg cgcctcactt 943021 ttttattcat gaacaggaac cattgtgtcc tctaacactc cgaaggaata gcctttttct 943081 tttaatttat tgattagtac cggcagcgca tttacagtag caggaagatc atgcatgaga 943141 attacatttg ggcggcttga agagctgtgt tccatattct caagctgctg taatacggcg 943201 gtcacatact gtgaattccg gtatttccag tccatgctgt cgatcgtcca atcccagtac 943261 acaaacccat ctttctccag attgcgaatt tgtgaggcgg ttagtgacgg cttgcttccg 943321 tatggcgttc tgacaagatc ggttttatat cctgtaatgt cctgcagcgt gtcacgcgcc 943381 tcctgcattt cttttagcgg agatgtcggt gtttgataga acaatctgtt attgtgggta 943441 acgccatgta aaccgagtgc gtggccttcc ttttctgctc ttttcacagc ctgcttgaat 943501 tcgttcatcc gcggtgacag cataaaaaac gtcgctttta catcagcgct tttcagtacg 943561 tcgagcaagc gggttgtaac ggctgaaggg ccgtcgtcga aggttaagta aaccgtttta 943621 tctcccatgt tctgctttgt ctgcagatgt tttatcagga gatcggggga gtcgtttttc 943681 agcttaaggc tttccttctc atctcgaagc tggccgtttg ttgtgacagt gacttccttt 943741 gctttcgttg aactgttgga ataacccaaa atcaccataa gcaaaagcag cacacataaa 943801 actgctaaac ttgcaaattt aaaagcaagc gaaactgcag aaggagaagc ctctcctctc 943861 gtttgtcgca taacaatctc tccattggca taaaatctct acataatgct gtacagcagg 943921 cagcttatga agatgcctta tgtttacaac ctatgtatta ccagtcaagt atacaggaat 943981 aaaactggaa agcacataga aaatttgtcg aaatgtcaga ttttaaggaa aaaataaact 944041 cctttccgct atagatctct tgatctttct gtttttcagc ttgtccaata tggtagaatt 944101 agtgataatg acagcttgaa tgacatcagg gacatctcga aaagggaggg cttttatgaa 944161 ggttttagtc aatggccggc tgattgggcg cagtgaagca tcaatcgatt tggaagatcg 944221 cggttatcag tttggtgacg gcatctatga agtgatcagg gtgtacaaag gagtattgtt 944281 cggcttacgt gagcatgcag agcgtttttt cagaagtgct gctgaaatcg gaatttcact 944341 gccattcagt atagaagatc tcgagtggga cctgcaaaag cttgtacagg aaaatgcggt 944401 cagtgaggga gcggtataca ttcagacaac aagaggtgtg gccccgcgaa aacaccagta 944461 tgaagccggc ctcgagccgc agactactgc ctatacgttt acggtgaaaa aaccggagca 944521 agagcaggca tacggagtgg cggccattac agatgaggat cttcgctggt taagatgtga 944581 tatcaaaagt ctgaatttac tgtataatgt catgacgaag caaagggcct atgaagccgg 944641 agcatttgaa gccattttac ttagggacgg cgttgttacg gagggtacat cctctaacgt 944701 ttatgccgtt atcaacggca cagtgcgaac acatccggct aatcggctca ttctcaatgg 944761 aattacacgg atgaatattt taggactgat tgagaagaat gggatcaaac tggatgagac 944821 tcctgtcagt gaagaagagt tgaaacaggc ggaagagatc tttatttcgt caacgacggc 944881 agaaattatt ccggtcgtga cgctcgatgg acaatcgatc ggaagcggga aacccggacc 944941 ggtgaccaaa cagcttcagg ctgcttttca agaaagcatt caacaggctg ctagcatttc 945001 ataaatgaac gaagaaaaga gcccgctttt tacagcgggg ctctttttat tttttaacaa 945061 atccaatcaa aatggagatc attggcgata tatagaggaa gaacgtaaat gggatgtagt 945121 ctatgactgg aacaccaagt gcgctcgcca taaatgcgcc gctgacgccc caaggaatca 945181 atgggttaat taatgttccg ccgtcctcta atgatcttgt cagaaatttt cgctggatgt 945241 ttcgtttgtc atataaagat ttaaatgatt gtcccggtat taatatcgat aaatactgtt 945301 cgcccgttgc caagttgacg ccgatgcttg agcagacagt tgctgcaaca agacggcctt 945361 ttgagcggat gcctttcatg acgccttcca atagtgcaga aatcaatccg attttctcca 945421 tcaatccgcc gagtgcaaaa gcaatcataa tgagagagac agagcccatc atggattgca 945481 gtccgcctct gttaataatt ttagcggctg cctcattgtc agtttcgaaa gttgtgccat 945541 tttgtaaagc tgtcataaac gcctgcaggc tgctgtaggg tacaaaaata gcagtcaaaa 945601 ttcccgagga aataattccg gcagtcagaa cggggattac tgatacccgt ttcattgcca 945661 gcaaaacgac taagagcgga gaaagaaggg cccacggtgt cacgtttgca gcatctttta 945721 ttccggttat gacctgctga atattatcgg ttgaagcagc gtccgctgac actgatgaac 945781 cgagaaagta aaacagaacg acagtgatga gcaaagctgg aatggttgtg cccatcatat 945841 ggcgaatgtg ttcaaagatt ggtatttcgc ctattccggc tgcaaagttg gttgtgtccg 945901 acatcggcga cattttatcc ccaaaacaag cgccgcatat gactgcgcct gctgtccatt 945961 caagcggaac gccagccgcg ctcgccacgc cgatcagcgc tactccgatt gtgcttacag 946021 ttgtcagact tgagccaaca agtgtgctga tgatcataca tgaaaacaaa gcagtcaaca 946081 gaaggtggct tggttcaata aaggataggg cataaactgt catagtcggt attgcgccgc 946141 tgtacatcca ggcgccgatt aagatgccga tcagcgctag aacaataatc ggctgtacgc 946201 cgtttttgat cccgtctaca atcccttttt caatgctctt ccagggaaat ccaaaccata 946261 aagctgctgc tgaaagcatg acaacactta aaaacagcgg gatatgaggt tctacatgaa 946321 gcaagaataa gcaagaaata ataatgcaca acatgaatat aaataaaccg acggctaacg 946381 gaaacgtcag ctttttttga gaatccaaaa taacacccca tatttatctt taatgctttt 946441 gtgcttttgg gcacgaaagc attataacag aaaaaaacga aaatctatgt tttttcacaa 946501 ttatgaatat aaaagaagtg agcacagggc gtgctcactt tacaatcagg acgggtatat 946561 ccgatttcgc tgaaagcttt tcacttacac ttccgaatat tagctttttc agcctgtttt 946621 ggtctctgct tccggttacg atcatatcgg cagaaatgcg gtttgcatgc tcgataattg 946681 attcagccgg atcgccttct aatatatcga tatctccatc tgcctgctgt tcattcagca 946741 tcattctggc ttcggcgatg acttcttccg tacggtcttc atagatcatt ggctcaggtg 946801 atgttacatc cgatatcagc ggatcaggaa cacttgtcat gcctccgctg atatagcttg 946861 cctcagctgc gggtctgggc gggtcgatga cggtctgatt gtctttcata tcatgtgaat 946921 gggcgacggt aatagcggca tttacggttt tagcaagatc aatggctgtc agaagcgctt 946981 tcttactatt ttcacttccg tcaaacgcaa caatgatacg gtcagcatgg aacatccttc 947041 tcaccctttc aaagcgtctt acaacactac tacccgaatt tgagcacaat taaccttttc 947101 ctattcaagt aatgattgac aataaaaggt tttgtttata tgatgataaa aagatgaaat 947161 cagaatggaa ggagggtttg ctatgccaag gaatttgcgt gtttatcaaa cagtttcata 947221 ttggcgcggc aaaccttttg ttctgttttc gtgaacggtt ttttaggtcg gaccgcgcgc 947281 tgaaaagcgc tgtgcgtaac atatcggtta aaaaaggcat ggagctgacg cttcatgcct 947341 tttttatata caaaatctaa ggaaagacag gtgtatggga tgtgaagaca aatacagagg 947401 cgagggcagt tcgtgccaaa ctggatgaaa aaagctgcaa ggaaaaaata gaaggcggct 947461 gatgaggaga tggggataga tgttttcagt tttgaaaaag cttggctggt tttttaaggc 947521 gtactggctg cgctatacga ttgcgattgt ccttttatta gcagtcaatg tcattgaaat 947581 gtttccgcct aagctcttgg ggaacgccat agatgatatg aaagcagggg catttactgc 947641 ggaagggctg ctgttttata tcggtatctt ttttgtgctg acggcggccg tgtatatcat 947701 gtcttatttt tggatgcatc agctgtttgg cggagcgaat ctgatggaga aaattcttcg 947761 tacgaagctg atggggcatt tgctgactat gtcgccgccg ttttatgaaa aaaaccgaac 947821 aggcgattta atggcacgag ggacaaatga tcttcaggcc gtcagtttaa ccacagggtt 947881 tggcatcttg acgttagttg attctacgat gtttatgatg acgatctttt tgacaatggg 947941 gtttttgatc agctggaagc tgacctttgc cgccattatc ccgcttccag tcatggcgat 948001 tgcaatcagt ctatatggaa gtaaaattca tgagcggttt actgaggccc aaaacgcgtt 948061 cggggcgctg aatgacagag tgctggaatc tgtttcaggc gtgcgggtga ttcgcgcgta 948121 tgttcaggaa acaaacgatg ttcgccggtt taatgaaatg accgctgatg tttatcagaa 948181 aaatatgaaa gtggctttta ttgattcact gtttgagccg acggtaaaac tgcttgtcgg 948241 cgcaagctat ctgattgggc tcggctacgg agcgtttctt gtattccgga acgagctgac 948301 gcttggagag ttagtgtcct ttaacgttta tctcggcatg atgatttggc cgatgtttgc 948361 aatcggtgaa ctcattaatg tgatgcagcg cggcaatgcg tcattagatc gggtaaatga 948421 aactctttct tatgaaacgg atgtgacaga tccaaaacag cccgctgatc ttaaagagcc 948481 tggagatatc gttttcagtc atgtcagctt tacatatcca agctcaacaa gtgacaatct 948541 tcaggatatt tcatttacgg tgcgaaaagg gcagactgtc gggattgcag gtaaaaccgg 948601 gagcggaaaa acgacaatta ttaagcagct tttgcgccag tatcctccag gtgaagggag 948661 cattacattt tcaggtgtac cgattcagca aatccctctt gaccgtctcc gcggatggat 948721 cggatatgtg cctcaggatc atttactgtt ttcacggact gtaaaagaaa atattttata 948781 cggaaaacag gatgcaactg ataaagaggt tcagcaagcc attgccgaag cacattttga 948841 aaaagatttg cacatgcttc cgtccggtct ggagacaatg gtcggtgaaa aaggcgtggc 948901 actgtcaggc gggcagaaac aaagaatttc gatcgcgaga gcactcatgg cgaatccgga 948961 aatcttgatt ctggatgatt cactttccgc tgtagatgcc aaaacagagg ctgcaattat 949021 caagaacatc agagaaaacc gcaaaggaaa aacgacattt attttgacac accgattatc 949081 cgcggtagag cacgctgacc tgatccttgt gatggacggc ggcgtcattg ctgagagagg 949141 cacgcatcaa gaactgctgg ccaataatgg gtggtaccgg gaacaatatg aaagacagca 949201 gctgttcact gcggaagaag ggggagcagg ggcatgaaaa taggaaaaac gttatggaga 949261 tacgcacttc tttatcgaaa attgctgatc acagccgtcc ttttgctaac tgttgccgtc 949321 ggtgcagaac tgactgggcc ctttattggc aaaaaaatga tagacgacca tatcctcggc 949381 attgagaaaa catggtatga agctgcggaa aaagataaaa atgccgttca gtttcacggc 949441 gtctcatatg tcagagagga ccgattgcag gagcctgttt caaaagcaaa agaagcgcat 949501 atttatcaag tgggaatggc gttctatttt gttgatcagg ctgtcagctt cgacgggaat 949561 agaacggttt ctgacgggaa gctgacgatc acaaacggag acaagagccg ggcatatgct 949621 gccgaaaagc tgactaagca ggaacttttc cagttctatc agccggaaat aaagggaatg 949681 gtgttactga tctgcctgta tgggggcttg cttgtgtttt cggtattctt tcaatacgga 949741 cagcattatc tgctgcagat gagcgccaat cggattattc aaaagatgag gcaggacgtg 949801 ttttcgcaca tacagaaaat gccgattcgc tattttgaca accttccggc cggaaaagtc 949861 gttgcgcgga ttaccaatga tacggaggct attagggatt tatatgtcac agtgctttca 949921 acatttgtga caagcggaat ctatatgttc gggatattca cggctttgtt tctgcttgat 949981 gtgaagcttg cgtttgtatg tctggcaatt gtgccgatta tctggctgtg gtcggtcata 950041 taccggagat atgcgtcata ttacaaccaa aaaatccgct cgatcaacag tgacattaac 950101 gcaaaaatga atgagtcaat tcaaggcatg accattattc aggctttccg ccatcaaaag 950161 gaaacaatga gagaatttga ggaattaaat gaatcacatt tttatttcca aaacaggatg 950221 ctgaatttaa actccttaat gtcccataat ctggtcaatg tcatccgcaa tcttgcgttc 950281 gtctgtctga tctggcattt tggcggtgcg agcctgaatg cggcggggat tgtttctatc 950341 ggtgtgctgt acgcgtttgt cgattatttg aaccggttat ttcagccgat cacaggcatc 950401 gtcaatcagt tttcaaagct ggagcttgca agggtctccg ccgggcgtgt ttttgaactg 950461 cttgaagaaa agaatacgga agaagcgggt gaaccggcga aggagcgcgc gctggggcgg 950521 gttgaatttc gtgatgtgtc atttgcgtat caagaaggtg aagaggtatt aaagcatatt 950581 tcctttactg cgcaaaaagg cgaaaccgta gcgctcgtcg gccataccgg atcaggaaaa 950641 agctcgattt tgaatcttct gtttcgtttt tatgatgcgc aaaaaggtga tgtcttaatt 950701 gatggaaaaa gcatttacaa catgtcaaga caggaactca gatcccatat gggtattgtg 950761 cttcaggacc cgtacttatt ctcgggcaca atcggatcta acgtaagtct ggatgacgaa 950821 agaatgactg aagaagaaat aaaaaatgca ctgcggcaag tcggtgctga gcctcttctt 950881 aagaagcttc cgaagggcat taatgagccc gtgattgaaa aaggcagcac gctatcctct 950941 ggagagcggc agttaatttc tttcgctaga gctttggcgt ttgatcccgc gatcttgatt 951001 ttagatgagg caacggcgca tattgataca gagacagagg ccgtgatcca gaaggcgctt 951061 gatgtcgtca aacaaggacg caccaccttc gtcatcgctc accggctttc aacaatcaga 951121 aatgctgatc agattttggt tcttgataaa ggagaaattg ttgagagagg gaaccacgag 951181 gaactgatgg cattagaagg ccaatattat caaatgtatg aactgcaaaa gggacagaaa 951241 cattccattg cataacgctc aaaaacccaa aacaatcgtg ttttgggttt ttggtttatg 951301 tagtcaataa gccagtccga cacggtttcc gacatactca cctgtaacga gctcacgata 951361 taaaaagtcc gcagtatcgc cgaccgaaat gcttgtgccg ccctcaggca aaacgttacg 951421 ctccgtacga taaacgccgg ttgctgttcc gtccgggagg taagtggggc agatgattgt 951481 ccagtctaat gatgattctt taagcatttc gtatactttt gcatgctcct tggctgcgcg 951541 ggtctgcttt cgtttcgatt catttgtttc aaaccggtat tttcccggtt catatcggga 951601 atctaggatc cctgcggtgc cgatcgtaat aagccgtttg atatgctgtt cctccataac 951661 ggagagaatg tgtgccatag cagttgacaa ggtatcatca ccatctgtgc ctagacagct 951721 gatcacgatt tcagcattct ccattatttt tttcacatct tctaagcggc gggcgttccc 951781 catgacagtt ctgtcttttg aaaggggaag atcagcatgt tgagatctga tcagagcgaa 951841 aatatcaaat ctttcatctg ctgcagcttg tgttaaaaag gcttgtccga cgcggccgct 951901 ggctcctaat aaagcgattt tcattaaaaa acctcctcgc ctttcattat aaaaggatgt 951961 tctcagtttg aacagcgcgg gaaagaatac ctgtacaaat aaacagaacg atgggaaaca 952021 tattcatgaa tcatggatac acttacgaat tgaaccagct cccaattcac aatggtgatg 952081 aatgacaccc cgattccctc cctttttttc taggatatgt ggagcaggaa aaaagggtga 952141 caaaataaag agagcgcgga aaccgcgccc tctatagcca tatattgaat tgttattgaa 952201 ctctgccgcc catttgctgc tgagcgaaag atactaaacg ttttgtgatt tctcctccga 952261 cagaaccgtt agcgcgagaa gttgtgtccg ctccaaggtt aacgccgaat tcagaagcga 952321 tttcaagttt catttgatcg atagcctgag ctgcgccagg aactagtaag tcatttgaag 952381 agttttggtt agccatgtgt aaaatctcct ttttatttag tatggttggg ttaactggag 952441 ttgcaccaat ctgtgaaccc ttctcgggtg tcactgccgc ctcggcgtaa cccaatgctt 952501 tgccggcttg ttactacgta ttatgttaaa atggccggaa aatcatgcgg agaattgtgt 952561 ggtaaatctt gagaaataaa aaaagcttag ccgtttaggc taagctagtc ataaatatga 952621 aaaagcatca gttcatgtat ctcgtttgta agagcaggct cgtcagcgcg ggcgggaaac 952681 aagtctcccc attcaatctc accgctctta tgatagatgc cttcataatg ggtcccttta 952741 taataaaatg aaattttcca tccgggcagc ttttcttttg ggaacaaagg tttccagctg 952801 aaatgagaaa tcattacggc cacgctcctt acatttggta tcaattgacc taaataaaaa 952861 cggcttatgt tcattgtatc attgtttcag aacatcattg aagaggccta aatatgcagt 952921 ttgtcccagc tttggataaa gataagcccg ctttattaaa aaagcggaca ggttacgaag 952981 gccacaatgc ttccggagat gtgattgcct tctcagataa atatgacgcg tattcaaaac 953041 ttcttcgttt tgtaagagaa tcaacatgat gcaaatttgg atgagaaaaa atgcttcggc 953101 ccgggcgcga attcgcttca aacatccata ctttaccgtt ctgatcaatg ccaaaatcga 953161 aaccaatctc cccgataaat ccctcgatat gatcatgaag gacatggctt gcagtcagtg 953221 ccgctgcaga aagcttttta atgacctcaa ctctttcagc gggatcatcg tatacttccg 953281 caagtgtctt tacagtgccg ccgttagaaa gatgtgttgt aatgctgttc tttccggaaa 953341 tttttacggc gattgctgtc actgtccatt ttccttttct gtttttattg gtatggacac 953401 ggaaatccgc tggtttgcct tgaaattcga tgagatcaac accttgctga atgagaaagt 953461 cggacgggtt gtgatgtttt tgaaattctg caaggaatga ggcggcatcg gaataatcaa 953521 ttgatgtaaa agttttggcg tcattcgtat gctttaccgt caggccgcca tctgttcttg 953581 tcagctgata aatgccggtg ccgagtgctc catttgccgg tttgatatag acttttttgt 953641 atgcgccaca gagctcatct atcagctcca cagacggtgt cagctcggat ctaggcaaaa 953701 agggtgccgt tcttggatct ttttcgagca attgatgaac gttccattta ttgaaaaacg 953761 ttttattaaa ccatgggatc tgatattcat cgatcagcct cttttttgta tgttgcaaga 953821 gaagtgaatc ttcaattttt cggttcggca aacggtcata aacgacgttc ggcaatggaa 953881 cgattttttt ctcccagccg ttttccctgt aaaggaggcc ttcaatcgtg ccttcctccc 953941 aattgatttg gtgcgcgcca aaaacgaagc agtagccccc ggcttgctcg tgtaacgtga 954001 caagtttaga aaaaaagagg gaacgatcct taaatgggcg ttcaagagat acagtaaacc 954061 ctgccgtaaa gatgccgact aacggcccga tatgcactgt atgatcatga atcagtatat 954121 ctgccctgct tcggtgggga agcaaaagct catgaaacag attttcagag agaagcacgg 954181 tttgttccag atgccgtctg taagcaacgt ggcatctgac aaccttcgtt ccgaatgcgg 954241 catgcaaaag tccgtcttgc ttcagcgaag agggcagaaa cagggtgttt tcactggttt 954301 tgtctatgcc gatcaaaaac cgtttaggat tcacgcggaa gaactccttt ctggctttgc 954361 tcagaaaaca gatattggca gcgttttagg ggacaagtgt acagctgttc tttttgctcg 954421 ggagagacac gcaggattga cttcctgcct ggtttggaat tgatatctaa aatccaaatt 954481 ctcccgtcct ttgcaagaca tatatcaaga ccgagttcaa acaacggccc atagcgctcg 954541 tcaagataat acggaaccga ttgggtaatt gaaaacacat catctagtaa aaccacttgc 954601 tgttttttcg gtatatcttc aaaccaggag tcaaatgtca gcgcatcaga tccgcctgac 954661 aaattggcca gcagcccgtg tttgtatccg cgtcttactg cctttccgac tgtattccat 954721 tcacctgctt cgtttttttc cataaacaga cgaatatcac aagggtattg ttccttatct 954781 tgaatgttta agtaaggctg aagcaaatat tgatgctgaa gcactttttt gcaccatgtt 954841 ttaaaagaag tctggttgga aaacgttttt gtctgcttat cctttccgat gtgataagta 954901 gcagtgatgt ttttcttgcc cagcttcaaa agaatcacgc ctctgcctcc cgcgccgaat 954961 gccggtttaa ggatgcaggc tttttctttg gataaaaagg agtgaatttg ttcgtagcgg 955021 ctcaccttta tcgtttcggg aatataggga ttgattacag agtgctgctg caaatcgtga 955081 aggacggtcc acttatcggg aagaccccgc ccgataaatt ccgttttcgg atattttttg 955141 agccactcaa cgattggttt tgctttttgg gaatgtgaat ccttgccgta aaaacagcga 955201 tcataaatat aatctggaat cgccatttca gtttcgttcc atgtgctgct ggccgaatga 955261 tagaccgatg ctttgacacg caaagtgtca ggtgaaatat caaatggtgt aaaccggatg 955321 aaacgtatgc cgaattcggg tgctcttttg gccagttctg cggaataatc cgcttcatgc 955381 tggcgggata aggacataaa accgagtgtt atcatggtga gactccccct tttattcaaa 955441 agctgccggc gggtgtccgc agctttacac taaatacatg taagacgaac gcagctgacg 955501 gtattctact ttacagaata cgattctcca ccttgcccta ttccaaaaga acaagctgat 955561 tttctaagaa caggaatttg tctcctcgtt tgctaagtga ttgcatgagc ctctataata 955621 cgtataggta cataatctat atgaaaaaag ctgaagcaca gatggaggaa gatgaatagg 955681 aatgggtatt gcaggaacct ttatttttat gatcgtgatc ggcgctgcca ttggagcggt 955741 gaccaatcat ttagcaattc aaatgctgtt taggccgtat aaagcgtact atttgtttgg 955801 gaaacgagtt ccttttacgc ccgggctgat tccaagacgg cgagatgaac ttgcaaaaca 955861 aatgggactg atggtagtca atcatctctt aacccctgaa ggcattaaaa agcggctcgt 955921 ctctgatgca gccaaaacgc aggctcttcg agtgggggaa cagctgattc aaaagctgtc 955981 actttctgaa gtgacagtaa aagaagcgct tgaaaaagcc gggatgaagc gccccgaaaa 956041 agctgctgat gcatggatca gcagctggac cgatgataag ctgcatgagc ttttccgcca 956101 atacggggac caatcgttaa aagagctggt gcctatagag gtgcaggaaa agcttgagga 956161 aaaaattccg atgatttcag gatatatatt gtcacggagt gtccgttatt ttgaaagtga 956221 tgaaggaaaa atccgtcttg gcaatatgat tgatgacttt ttaaaagagc gcggcatgct 956281 tggaagcatg gtgcaattgt ttcttggcaa ttcaagcctt gcggatcgcg tgctgccgga 956341 gctgctgaaa ttcttgcgca atgaggaaac aaataaattg ctttctgatc tcttaaaaaa 956401 cgaatggggc aagctgaggg agtatacgtt taatgaagca gatgaaaaat ggaatgcaaa 956461 ggcgctcatt ttcagtttga aacgaagagt gctgcaagca ttttcgactg cccctttctt 956521 caacaatacg attggcacgc ttaccgtccg ctatgaatct gagctgaccc agcaaatgct 956581 gccggcacta ttagacaaat tgcttgaagg tatttcgtcc aaccttgaaa gtgtcttaaa 956641 acggttgcgt cttgaggaaa tcgtcaagga gcaggtggat cagttcccgg tggagcgtct 956701 tgaagaaatg gtgctgtcca tttcaaaaaa agaatttaaa atgattacct atttgggggg 956761 ccttctcggc ggaattatag gcgcgattca agcattgttt gtcatccttt tttaagaaga 956821 aatggttttt gattaatgaa aggagctcca tagtctgtta tagtggagtg gtatgtcaaa 956881 cggcaatgat gaaaggagct atttacaatg gctgttaatt tttatgatgt agcgtatgat 956941 ctggaaaatg cattacgcgg gagcgaagaa ttcacccgtt taaaaaacct ttacgacgaa 957001 gttaacgcag atgaatcagc gaagcgcatg ttcgaaaact tccgtgatgt acagcttaga 957061 ctccagcaaa aacaaatggc aggagaagag attacacaag aagaagtgac gcaggctcaa 957121 aaaacagttg cgcttgtaca gcagcacgaa aaaatttctc agctgatgga agcggagcag 957181 cgcatgagca tgctgattgg tgaattgaac aaaatcatta tgaagccttt agaagagctt 957241 tacggcagtg ttgaaggcta ataagcaaaa tcccttcttg gataagaagg gattttttat 957301 tcactcagca aacttggaaa tccaatgaat cttttacctc tccattgatg atgactgata 957361 atgtatgaat tcctttgtaa tgctttctgg tggttaaatc cttaaaggat tggattcttg 957421 tgtatgactt cgtttcgttt tttcgtatat ttgtttctgt tattttaaat actttctgat 957481 gacgctggcc tcttgctttt acaaaatcaa ttgcgtactc aattcttact ttttgatccc 957541 tgtctgaatg aatatagaaa gaaaattcaa ggctttcgcc aataactata cgtttgggct 957601 ggcatgttaa atcatgtagt tgtatcgaat cagcattttc ataaccaaaa agcgctaagg 957661 cctgtttatc accctttttt aataaggtcc gataggcgtg tttgataatc cagtctgtat 957721 ggggatgtgt tccgtaccat tgatctgcga cttttctcag taaatgagga tgcgtttttg 957781 atatatcatt aaggttgttg gccacgcttt ttcttacata taaagactcg tcctgcatca 957841 gcttctcaag gatcggcaat acgggggaag ggtccgattt caaagccggt atcgattttc 957901 cccatggcag gcggggcctg ctgccttcgc tcgcaagtct tctcacgtgt tcatttttat 957961 gctcagacca tgcaagcaat tgtgcaatca tcttttcttg atctaacagc aaaaaaggcc 958021 ttacagcaaa ttctgaggtc gaatattgcg taaaggattc caatgccttt attgattctt 958081 cccaatgcgc taacccgtac tgttccacat aatctggaaa taaaattccg ctgagtcctt 958141 taaaatgagg ggctgtatcc cgtaaaattg tgagcgcttc aacgtattgt tttggcaaag 958201 tttcgtataa agaaactgtc acgcggcgca tccgctcttt taaagtgagt tcaggccagt 958261 cctccagccg taatgtatcc aagaatctgt ttttgttaaa atcaggatag gatgacctta 958321 catgatggat caactgagat atcagttctt cattatatat ttcttttaaa tcagccatat 958381 aaacaccgct ttttcgttta ttatttatat tgtatgggaa tgtacgttct ggatcaagtg 958441 tatagtccta aaaattaaca actgatccta ccacggatat acaaaagttg gttacttttt 958501 ttagttaaaa aaacccttgt catcggaaag gaaaactgag ataataacat tgaaagcgcc 958561 tacacttacc tatttcaaat ggatacggtc gcatatcatg ccgttatata gaggggataa 958621 gcaacagaga gtaagtgttc ggagcgcatc attggtcaaa caaggggttc ctgatacatg 958681 atttttcgta aatcgaaata acgatattag ggagaatggc tgcttcgatc gtatcctatc 958741 aacaagccat acataaagtc tgctgagcca ggcttttttt gctttaagaa aaggttgttc 958801 taaacacaga gacagggtca tatcctatac acaagtacag tcatcaagga gggggacatc 958861 tctgtgtcaa aacaattgct tgccttaaat atagatggag cgctgcttcg gtcgaacggg 958921 aagattcatc aggcaacgaa agacgcgatt gaatatgtaa agaaaaaagg gatttacgtc 958981 acacttgtga ccaaccgtca ttttcgctca gcacagaaaa tagcgaaatc gctaaagctt 959041 gatgccaagc tgatcaccca tagcggggca tatatcgctg agaaaattga cgccccgttt 959101 tttgaaaaaa gaatttctga tgatcatacc tttaacattg ttcaagtgct ggagagctat 959161 caatgcaata ttcggcttct tcacgaaaag tattccatcg gaaacaagaa aaaggtgaat 959221 tcgaatttat tagggaaagc actcattcat ccgtctgacc cgatctttta tccagtccag 959281 ttcgttgaat cattaagcga tctcctcatg gatgagccgg tgagtgcacc cgtcatcgag 959341 gtgtacacgg agcacgacat tcagcatgac attacagaaa cgattacaaa agccttccct 959401 gcggtggacg tgattcgcgt aaacgatgag aaactgaata tcgtcccgaa gggtgtctcg 959461 aaggaagcgg gtttggccct cgtcgcttca gagctgggcc tgagtatgga tgatgtcgtg 959521 gccattgggc atcagtatga cgatctgccg atgatcgaac ttgccggtct tggggtagcg 959581 atggggaatg ccgttccgga aattaagaga aaggcagatt gggttacaag gtccaatgac 959641 gagcaaggtg tcgcttatat gatgaaggaa tatttccgaa tgcagcagcg aaaaggattt 959701 cttgataagt tccacatgaa acgtgtgtaa aaaagccgct cgcgccctga caggtgcggc 959761 ggcttttttg ccggattgat tttagcagtt tatttctgta cactaaagaa agttttgaat 959821 ctgataaatt aggtgatgaa gttgcaaatt aaaatagaag gcatacatga tgaccgcctg 959881 catcggcctc tgcaaaatat tgcaaatttg ttttatgaag agtgcgagct tgcgtatggc 959941 ggagaggagc ccgcagattt tgtcatttct ttagcgttgt cacaaacgga tgagcatgtg 960001 acggtttctg gagaagtgaa gggtactggc ataaaggaac agcatacaaa attcttttct 960061 ccagacatga ctgaaaaaga agcttttaag caagtgaaaa acacaatttc ttatgtgtat 960121 ctcaatcttc ttcaggcgca tacgggcatt acgcagaagt ggggaatcct cacaggaatc 960181 cggcccacaa agctgcttca taaaaaactg caaagcggaa tgtccaagga gcaagcgcat 960241 gctgagttga aaaaagacta tttaattcat gatgaaaaaa tcatgctaat gcaggaaatt 960301 gttgaccgtc agctggcggc agtgccggat ttgtaccgag taaaggatga agtcagcatt 960361 tatatcggca ttccgttctg cccgacaaaa tgcgcgtatt gcacattccc tgcgtacgct 960421 atccaaggac aggcgggcag agtcggctca ttcctatggg gactgcatta cgaaatgcag 960481 aaaatcggtg aatggctgaa ggagcatgat gttaaggtta caaccattta ctttggcggc 960541 gggacgccga caagcattac agcggaggag atggatctgc tgtatgaaga aatggtccgc 960601 tccttcccgg atgtgaaaaa cattcgtgag attacggtgg aggccggtcg tcctgacacg 960661 attacagaag aaaaactcgc cgttttaaac aaatatgaca ttgatcggat cagcatcaat 960721 ccgcaatcct acgaaaacga aacgctaaag gcgatcgggc ggcaccatac ggttgaagag 960781 accattgaga aatatcatct gtcacgccag cacggcatga ataatattaa catggacttg 960841 attattggtt tgcctgggga aggcgtgaag gagttcaggc acagtctttc agaaacagaa 960901 aaactgatgc cggaatccct taccgttcat actctttcat ttaaacgggc gtcagaaatg 960961 acgagaaaca agcataagta caaagttgcc ggcagggaag aggtttctca aatgatggaa 961021 gacgcggtag cctggacgaa agagcatggg tacgtgcctt attatttata ccgccagaaa 961081 aacattcttg gaaaccttga aaacgtcgga tactctttgc cgggacaaga aagcatctac 961141 aacattatga ttatggaaga ggtgcagacg attattggca tcggctgcgg cgctgctagt 961201 aaatttattg atcgggatac agggaaaatt acgcattttg cgaatccgaa agatccgaaa 961261 tcgtacaatg agcgcttcga gcactacacg gacgaaaaaa tcaaatattt agagcagatt 961321 tttgaaaaaa cgacaaagca gcactgatta cagtgctgct ttttttatcc ctgttttttt 961381 gcgggctgaa cctcaggctt ccatttaaat accttgttca gcaagcggta aattcgtttt 961441 gattcctttg tgacaagcgg tcccaaaatc gccagaatga ggacatataa tgcggcaaac 961501 ggctttaatg tggccgacag tccgccggct atcccgagat tcgcaacgat aatcgaaaat 961561 tctccccgcg atacgatcgt cagcccgata ttcgatgaag ccttatgaga aagccctgcg 961621 cgtcgtcctg ccaccattcc ggcgataaaa tttcccagaa tggtcaaaat cactgcaccc 961681 aacgcaagcc aaaccgcttc accaagcgaa aacggatcga tgctgaggcc gaagctgaaa 961741 aagaacatcg caccgaagaa gtcgcgaaac ggaacaacga ggtgttcaat cctatcggaa 961801 tgctctgttt ctgaaaagac caaaccgagc agcagcgcgc cgattgcttc tgctacatga 961861 atcgtctctg aaaaaccggc gataaaaaag agtgctgcga aaatgacgat aataaacact 961921 tcgtttgagc gaatgtccaa cagtttgttc aacagcggcg ggagttttct tgctgcgata 961981 aaaaacagca gcatataacc gaaggcgatc aaaatggaca agagtgcact ccctacggat 962041 gtcgcatcac ctagtataag gccggaaaca acggacagat atacggcaag gaaaatatct 962101 tcaaacatga tgatgccgag aatcaattcg gtttccgggt tggcggttct ttttaaatca 962161 acgagcactt ttgcgacaat cgcacttgac gagattgtga tgacgcctgc gaggatgagg 962221 acttccagaa aggaaaatcc ggtgataaac ccgtaaagca gtccgaggct gaagttaatc 962281 aaaatataaa tcgtcccgcc gaccgcgatt gattttcctg atttgattaa cttcccgaca 962341 gagaattcga gtccgagata gaagaggagg aacagtacgc ccattcgccc gaaaaactcg 962401 atgatttcac tgctttgaat aaatgttaga tcaataatcc ccattttcgg cgcgtgcggt 962461 ccaacaagca ttcccagcac aatcagaaac ggaataatcg aaaatttaat tttattggcg 962521 atcacactgg cgattgccac aagcacaagt gcagttccga cttcaaatac aagatggtcc 962581 atcggggctc acacgccctc tccagaaaga aaatcgtgaa tcagtttctt cagatgcttt 962641 ctctcacctg agaggacaag ggtgtcattt tcttcaataa tcgaatccgc tccgggattt 962701 aggagctttt cctggttgtg tttgataatc gcaataacag tgacatcgta attctggcga 962761 acatcaagct caccgagtgt gcgtccgatc gatttggcgc ctttttcgac cttaaaccat 962821 tcaataataa gatcgctgaa ggccatttcg atggactcca gagcttgcgg tttatagacc 962881 atgcccccga gaatagctgc aatttgcctt gcttcagaat catccaatga aatatttgaa 962941 agaagctcat ccgggtcccg gtcattaaac cggtaaattt cccttcttcc gtcatcatga 963001 atgataatcg tcattttttc gtggcttctt gtttcgattt caaacttttt gccgatgccc 963061 ggcagatcgt tttctttaat attcaatgaa aatccctccg aatgtagtgt tggcagtatg 963121 gggtgagtta caaataaaac ttgagcaaat tatattcgga ggtaattaga ctggtatttg 963181 acagggacgg ccaaagcctt ttccagcctg tttatcagcg gttcgtcaag tggtttgaca 963241 gagagctgcc tgacagactg cgccagcggg ctgtactctt tgatcagctc agccgggtgc 963301 atgctgcccg gcgatggcgt ttttgccgat tgtgtttcct gcggatatga agacataggc 963361 acatagctgt cagtgcttgc ttcaaactgg gaaggcagaa ccacgtccga agggggaaag 963421 tacaccataa ataaacttaa cagaaaactg atcagcaatt tatccatgtt cctttcctcc 963481 cttctcatca agatatccct tctttttcac tatataaaac tttatgtttc cattcaaaca 963541 atatgcattt ttcagtatct attgaccttg aaaaataaaa aggtttattt ggggatggcg 963601 gggaatgtat aggagaaaga aaaaagtaag cgcatacatg gaggtgcttt taatggagtt 963661 tgttcaatat gcatgtaatg gggccgttgc agagattatc ctgaatcggc ctgatgccca 963721 tcacgccctg aatgaacaga tgctgtctga attgaaggag gcagtcgaaa tggcggctgc 963781 aagcgaggcg ctcatcgttc tcctgagagg aagcgggaaa ggcttttcgg ccggcggtga 963841 tatcaggatg atgacgtcag agcatgaccc tgaccaattt aaacggctga tggatacgat 963901 tgaggctgtc accctgaatt tatatcagat gaagaaagtg acaattgcag ccattcatgg 963961 tgctgctgcg ggactgggcc tgagtttggc gctttgtgcg gacattgtgc tcgctgaaaa 964021 aaacgccgtt ctcgcgatga attttatcgg cattgggctt gttccggacg gcggaggaca 964081 ttatttgctg aagaaaagaa tcggtgaagc aaaagcgaaa aaactgattt ggagcggaaa 964141 aaaactatct gcctcggaag ctgccgatat ggggcttctt gatgggacat ttgccggaga 964201 ccctgccgaa ggcgcaagac ccattatcga aaccctgttg gcctcccctc ttttggcgat 964261 gatcgaaacg aaaggtattt ttcaaagcct ccaaattgaa gaactgaaaa aagtgctatc 964321 ccttgagcgc agcgcccaag agagaatgag aaggaccaag gatcaccaag aaggaatccg 964381 tgccttttta gaaaaacggg agccgaagtt tcaagcgtaa cagatcagcc ggaaagctga 964441 tcatctgtga aacaaaatca gctttccggc tgcattgact aaacgatgag tatgactatg 964501 aagctctttt tcttttaaga gggcttcacc atgcgttttt gccgcttctt catgttctgc 964561 ctcgaattgc tcgtttacca gcgtgttccc cgaaggatca aatacggtaa ggaaataatc 964621 agccatcagg tttctcctcc attttaaggt ttatcagtct ttcttcattt atattctaaa 964681 aaggaaatca aaatccttta ttatgcttta tccaaaatta gtatataatg ggtcagggaa 964741 ggaggagatt cagtgcttac aattgatcac gtaacgaaga catttggaga ttataaagcc 964801 gttgacggat tggacttaga tattccggaa cagcaaatgt tcggtctatt aggcgcaaac 964861 ggagcgggaa aaacaacaac gtttcgcatg atcctaggat tattaagcat tacggagggc 964921 tcaatcagct ggaagggccg tcctgtgaat tatcatatca gcaacaaaat cggttatttg 964981 ccggaagagc ggggccttta tccgaaaatg aaggtaaggg atcagctcgt ctatcttgcc 965041 agattaaaag ggatggagaa gcgagaggct gtaaaagagc tcgggacatg gcttgaacgc 965101 ttcaatatta cagattacga gaataagaag gtggaagagc tttcgaaggg gaatcagcag 965161 aaaatccaat tcatttcggc agttttgcat aagccggagc tcctgattct tgatgaacca 965221 ttcagcggct tggaccctgt caatgttgag ctgctaaaag aggccgtgat ctcgctgaaa 965281 aacagcggtg tttctatttt attttcaagc catcggatgg aacatgtgga ggagctttgt 965341 gagaaccttt gcatattgca gaaaggaaaa ccggttgtac aaggcaagct gaaggagatc 965401 aagcgttctt tcggtaaaaa gaatgttacc attcactccg atgacgatct gcgctttttg 965461 cagtcccatg aaggcattct tcaatggaag gaaacggcag acggcgtcaa gctgcagatt 965521 gccaatgaag acatttctca agagattttt gcgatgctcc aaggaaaagg gtttatcaga 965581 aagtttgagc ttgaagagcc gtcactgcat gatattttta tagaaaaggt gggggccgtc 965641 tatgaataaa ttttggatca tgctttctca tacatacaaa aataagatta tggcaaaatc 965701 ctttattatt tcgactgtca tcacggtgct gcttgtttta gttgtaacga atctggagtc 965761 gatcatttct ttgtttcaag gtgacgatgc gaaagaaaaa atcgccgttg ttgatgaaac 965821 aaacgaatta tatccggttt tttctaagca gctgaaagcg gtggatacag acggcgatct 965881 tgatgtgaag ctgtcgaagc aatcggagga tgaggtcaca aagcaagtca aagatgaatc 965941 actcgatggc atgctcatca tcaaacgaga tgaaaaaggg accatttcag gaacatataa 966001 agcgttaacg atttctgatg aaagcacgta tcaaacactg cagcaggcgc tgacgcaaac 966061 caaaacagct gtcggaacag cggagctcgg cgtgtcgcag gaaacgatta gcagccttta 966121 tgcgcctgtt actgtggggc agaaggcgct gaaagaaggg gcaaagtctg aggaagagct 966181 tggccagacg gtagggcttg tttacattat gctgttcgtc atttatttct cggtgattat 966241 gtatgccagc atgatagcga tggaggtcgc aaccgaaaaa tcttcgcgag ttatggaaat 966301 cctgatctca agtatgccgc cgatccagca aatgtttgca aagctgcttg gtatcgggct 966361 tgtcgggatc acacagcttg ctattattat aggagccggc tctctgtcgc ttaagctgaa 966421 ccaaaagagc gaaacggctt catctgtcgg cggattcctt aatttgaccg acgtatctgc 966481 aaccactgtc atctatgctg tcattttctt tttgctcgga tactttttgt acgcgacact 966541 tgccgcgttt ctcggcagtg tcgtcagcag aatagaggac gtgcagcaaa cgatcacgcc 966601 gatgacgctt ttggttgtcg ccggttttat gatcgcgatg ttcggtttga atgcgcctga 966661 cgcaggattt attacggtaa cttcgtttat tccgttcttt acgccaatga ttatgttcct 966721 gcgcgtcggc atgcttgata ttccgttctg gcaggcggct gtcggaatcg gaatcacact 966781 gctcaccatt gtcatactgg ccgttatcgg cgccagaatt tataaaggcg gtgtattaat 966841 ttacggcaat tcaagcgcgt tcaaagcgat caaacaagcg ctacgtttag cgaaaaactg 966901 attggaaaac agcctgggga ttctcaggct gtttctttat tgacagaacg tgcattcgca 966961 agaattcggt gctaaaataa gggtacttca tcctggaaag gagcagaatg ttgactgatc 967021 taacctttat tcatgcggca gatcttcatc ttgacagccc gttttacggg atatcgcatc 967081 tgccggagcc gatttttgcc cggattaaag aaagcacgtt tgcaagcgtg agacatatga 967141 tagacgccgc agtgagagag cacgttgatt tcattttgct tgcgggagat ctgtttgatg 967201 aagccaatcg aagcttaaag gctcagctct ttttgaaaaa acagtttgaa agactcagag 967261 agtgcggaat ttcggtatac gtcatctttg ggaatcacga tcatcttggc ggggagtgga 967321 cgccgattga atggcctgag aatgtccata ttttttcgtc cgctgttcca gaagaaaaat 967381 cgttttttaa agaaggcagg cgcatagcaa gcatttacgg cttcagctat caagccagag 967441 cattgatgga aaaccaagcc gcccgctatc ggagatcaac tgacgcaccg tttcatatcg 967501 gcatgctcca cggcacgctg tcaggatctg aaggacacga tccgtattgc ccgtttacac 967561 atgacgacct cgtgaaaagc gggatggatt attgggcgct tggccatata cataaacgcc 967621 aggttctatc tgccgagcat ccggcagtca tttacccggg aaacacgcaa gcacgccata 967681 taaaggagac gggagataaa ggctattatc tcgttcatgt gacaaacgga gatatatctt 967741 atgaatttca gagagcgcat gatgtcctgt gggaaaaagc ggcggttgat gtgacggagg 967801 caaagaatat gacagccctc ttccaaatgg tggaggacac gttttcgaag ctgcggaaaa 967861 aggggagccc tgtttgtgta aggcttgttt tacaagggac ggcgccggaa tggctgctgg 967921 aggcgccaaa aggcaccttg gatgagtttc ttgaagctct tcaggaacaa gaagcggaag 967981 aggaacgttt cgtttggcct cttagattgg acgatgagac agaaaacgaa gcaaacctaa 968041 caaaccttga tccttttttt ggcggtttat ttgaagacat tgatcgcagc gatctgtcag 968101 acgtgctgga agggcttgag cggcatccag tgtatagaag gcacgcggac cggtttagcc 968161 aagaggaggt aaaggaaata aaagagcagg cacagataat attgaaaaga cagcttaagg 968221 tgcttgatac atgaggcggt gacagctttg cgaattatat ctttacatat ctaccaatac 968281 ggaaaatttt ccaatcggac ctttgacttt tccgcctctc ctgtccaagt catctacgga 968341 ttaaatgagg caggaaaaac gacgatgatg tcattcattg aaagcatgct gttcggtttt 968401 ccgaaaacga aaaagtatga accgaaaaca ggcggtgtct acggcggtgt tcttgaagct 968461 gaacatcctg agtatggggt gctgaagatc gaacggacga aagggactgc cgaaaaacta 968521 agcgtgtaca cagaaaaggg cgaagtaaag cagggagatg ttttaaagca gctgttccag 968581 ggcacagaca ggtcgttgta caaagccata tattcgttcg acgtattcgg gctgcaggaa 968641 attcacgcct ttaatcggga caagataggg gaatttttgc tcttttccag cttgtttggt 968701 gctgaagccg tatcaaagct tgattcaagg ctgacgaagg aaagcgaaag gctctataaa 968761 ccaaatgggc gaaaccctca attgaatcag gagctggaaa cgcttaagca gctggcagtt 968821 aagctaaaac aggctgaagc agaggaagcg ggctatcatc agcttctcga ggaaaaacga 968881 acgcttgaag cccgccttgc agccgcggaa accgaattga aagagacggc gggacatatc 968941 cgaatgattg agggagcgat tgagcgaaag ccgctgctaa atgaaaaagc gacactcgaa 969001 caggtgattg cagaatttcc ggaacacgca ggacaatttc ctgctgacgg actgcatcag 969061 ctggaaaaat atgaatccca tcttcacccg aaatcagcac agcttgaggc gcttcgggtg 969121 aagatggcgg agttggacaa acagaggcaa aagcttatcc ccgataaaga actattggcg 969181 aaagaaacgc tgatacaaga gctttcggca gcgtttcata tgtaccaatc ctggggagaa 969241 cagctggcag ccattcaggc acagctgcgc cagacgtctg cgcagacagc ggcagggctg 969301 gaacagctca ataaaacgga tgaaaatgag ctcctgaata tgaacacctc atatgattat 969361 gaatggcagc ttcagcaagc ggtgcagcaa tatgtacagg caagagacag aaaacggcag 969421 cttgacgaga cgtttgaact tgcccggcaa gagctggaag acgcggaaaa ggccgttcgt 969481 gccgcttcgt ccgcgattct tgaaaacagc caaagaaaag ataaagaagc agctcttaga 969541 gcatatgatg aaacacaggg gcagcaccaa gagcaagcga agctcagaga acagctaacg 969601 ttttttgaaa gacagcaggc taaacagaaa aagactgtca ttgcagctgg tatgttgttc 969661 atcgttctct tttctctgct gcagcaatgg attcccgcca taagtttcgg cgctgcactt 969721 attgtgtatt ggcttgtttc aggaaagtcg tcttctcgaa acagccgaga gacaagacag 969781 cccatgacgg atatttcacc agcagaagct gaaatgctta gagaagcgtt atgggaggat 969841 gaccgcaata agcagcacct tctcacacag cgtgcagcgc tccagcaaaa agaggcggcg 969901 tatgaaaggg tcatccagca gtttgaacag tgggaagccg aaatggcgcc gtcctttaca 969961 caggttgagc gttttatgaa tgagctcgga tttaaggaag atccatcatt tttgcttgat 970021 gcatacagct taatgaagga tgttaaaaaa gaagtgaaga aaaagcatga gctgaccata 970081 gaagcaggca ggctgaaaaa gcaccggaga acattcgaag aacgcgtcag tatgcttctt 970141 cccgtgaatc agagtcagga tatctccatt tcggacgccc ttcacacatt gcggaaaaac 970201 attgaacgtg aaaaagaaat tgagaagcaa aaaaaggaaa ttgaaacaga tattcattat 970261 acaaaggaac agatgcttga acttgagcaa gaaatacagt atttccacgc acagattgaa 970321 cagttatttg ccgcggctgc tgcaaaagac agagatgcgt tttttgccat agccgccatc 970381 agcaggcaat tgaaggatac ggagaacaag cttcatcacg taaacgcaca gcttcaaggc 970441 gggtacccgg aggaacttga actggcggat tccaatacgc tttctgaatt gaaagataag 970501 caatttgttg agaatgaaag aaaagagcgg ctgactgagg agatcgagca gctccgcagc 970561 caaatcgcac tgctctcagt caaacaggaa caattagagg cttcgggaat ggtctcagac 970621 ctcaagcttc aaaccgaaat gcaaaaagaa cgtgtgaaag aaacggctaa aaaatgggcc 970681 tccatacaaa tggtcaaaca ggtgatcaga aacaaattgg agcggcataa aaaaatcgag 970741 cttccgcgcc ttctggagac ggcaggagaa tttttccgtc ctctgactga cggaaactac 970801 caaaccattt atttttccga aacggatgat tcgatcatgg ttatgcatcg cgatggcact 970861 gtctatcatg cggaagagct gtcacaaggg acgtgtgaac agctgtatac agcgatccgc 970921 tttgctttgg ccgttacgcg ccagggtgag tcaaagcttc cgttccagct tgacgacagt 970981 tttgttcatt ttgatcagga aaggctgaaa cgtgtattac atgttctgta tgatttatct 971041 gaaggcggta ggcagatttt gtattttaca tgccatgagc acgtaaaaga tgcatttcat 971101 agcagccaaa tcatccattt ggtgtcataa aagaggttct atagctgaaa atcggtatgt 971161 gatatactgg tattatgtaa gatacggagg gagctttaat agaatggcta aagggattat 971221 gctacatgag gttggcgaac aggtggacca gtatctattg attaaatcct cgacgaaagg 971281 gattgcaagc aatggaaaac cgtttctgac gctgatgctg caagaccagt caggcgatat 971341 tgaagcgaag ctgtgggatg ccaagcaaag tgatgaagtg acctatgcgc cgcagacgat 971401 tgtcaaggtc gtcggcgatg ttcaccatta tcgcggacgc acccagctga agctaagaaa 971461 tatcagaccg gtaagcgagc aagaaaacgt caatattgat gattttttag aaaccgcgcc 971521 gattccgaaa aatgaaatga tggataccat cactcaatat atatttgaaa tgaaaaatcc 971581 gaatatccag cgaatcacaa ggtttttggt taaaaaacac gaagctgagt ttatggatta 971641 tccggcggct acgaaaaacc accatgagtt tgtctcaggt ttggcgtatc atgttgtctc 971701 tatgctgaac ctggcgaaag caatagcaga tttatatcct tctcttgatc gtgatctgct 971761 ttacgccggt gttatcctgc atgatcttgg aaaagtgaag gagctgtccg gccctgtttc 971821 cacttcatat acggttgaag gcaatttgct cggccatatt tccatcatgg tgacagagct 971881 ttcaaaagcg gctgaggagc ttcaaatcga ttctgaagag gtgttaattc ttcagcattt 971941 gattttgagt caccacggca aagcagaatg gggcagcccg aaaccgccta tggtgaaaga 972001 agcggaaatt cttcactata tagacaatct ggatgcaaaa atgaatatga tggacagagc 972061 gcttgagcgc gtgaagccgg gcgagtatac tgaacgtgta tttgcactgg aaaaccgttc 972121 cttttataaa ccgacatttc ataaataact taaaaaggac tgatgctgac atattcagct 972181 cagtcctttt tgatgcgtct ttcccgcaca taactcgtct cattcccgca tatggttaag 972241 aataaagaat ctatgcaaag ggggaggagc ccgtgttatt ttttccgtgg tgggtgtatc 972301 tttgtattgt aggcatcatt ttcagcgcat ataaacttgt ggcggcagcc aaagaggaag 972361 aaaaagtaga ccaggctttt attgaaaaag aaggacagat ttatatggag aggatggaaa 972421 aggagcgaga acgccgcagt tctcagcagc atgaagaaga aaatcaaaac cattccatcg 972481 cataaaaaaa gctgtgcggc tcaatgagcc gcacagcttt ttttattatt tagaattgct 972541 tgaagatgaa gaagtgctgt tgcttgttga agatgtatta aatgtgtctt tcagatcttt 972601 atcttttact tcgatgtcag ccttcttcat gactttttga acagcttcct gaacagctgc 972661 gttgtcattt aatttttgtt caagcacttc agatttcagt tcttttttca tatcatcata 972721 tttgccgcgt tcttctgtct ttttaatgat atggtagccg tattgcgttt tgacaggatc 972781 actgacttca cctgttttta atttgaatgc agctttgctg aatgtttcgt ccatttggcc 972841 ttcttttgcg aaccagccaa gatccccgcc ttttgaagca gagctgtctg ttgagtattc 972901 tttcgcaagg tcttcaaact tctcgccttt tttcagcttt ttctctactt cttcagctgt 972961 ctttttatca gcaacaagga tgtggcttgc acggattttg ccttttaagc cttcccagta 973021 ctctttgata tcggcgtctg ttactttgat gttatcttta gccgcttttt gtgtcagcaa 973081 ttcatatttt acttgttctt tcaggtaatc tttgccatat tgcttttcga gggcagtata 973141 ttgatcgcca agctgcgttt tgtattcttt cagcttgttg tcaatttctt tatccgaaac 973201 tttatacttc ttgtccaata ctttttcttg cactagctgt gtcagtacgc ttgcgccagc 973261 tgttttcttc atgtttgtgt aaagctcgcc ttttgtgaca tcgcctgcgt ctgtttttgc 973321 gataacttct ttgtcgccgc tgctgcaagc actgagagcg aggatgcttg tagcagtgat 973381 agctgctatt gcgattttct tcattgtttt caaacactcc taatcattcc aaattaaatt 973441 acctatgcgt atcataacat attgtggctt tctgtaaaaa gattttaaat aaagggcatt 973501 cgtctagtca aacttttgct gatgacatac ttatatattg atcaagaaaa ggaggtatgt 973561 aacatgagcg gaggatactc taacggattc gcgttgctcg tagtactgtt cattttgctt 973621 atcatcgtag gtgcagctta catctactaa gcagcccgag gatcgcttgc aacataagcg 973681 atcctttatt ttcactagcg cctaatcgtt tcaaacatga attgcataac atgtaattgg 973741 taaataaagc ttattacagg aggtgctatt taagatgggt gaagtatttg caggcggatt 973801 cgctttattg gttgtgttat ttattttatt gattatcatc ggcgcttctt ggctgtacta 973861 atcaacataa aaaagcatag ctgcttaatc agcagctatg ctttctttcg tatttacact 973921 gtaaaggaga tctccacaaa cgaagagatc agtaaaatta atatagatac attaataaat 973981 cggaatacct tatcttgccg ctcttcagga atctctctga caaggcataa tgtattggtg 974041 agcctgttta tgaaatataa aataaacacg gcagccacga taaaatagaa taaaatgatg 974101 ggagattccc cctctctctg aactgtccca tattacatta ccaaatattt attaaaaaag 974161 atagaatgca aattgaaaaa tcgccaccag caccagggtt tgactacttt tcaacaagaa 974221 tatccaagcc gtcagcttcc tgatcaataa aagcggtttt cggtgctttt atcagcttga 974281 gagccagcag gaaatcaggc agacagtagc cggcgtgaat gcccgagatc atgcaaaaat 974341 aatgagcgtg attcggaaat gccagtgctg cgtaaaacaa taccggtgta atcagcaaga 974401 acgggctgac gagtgaaatc agcattgttg tttttggtat acgtttccat gtgcgcatgc 974461 gcaatatgta aaactttttt tctatttttc tttttttgca gatgattggc aggacatgga 974521 tgactttatg tacaaataaa ataacgacga gcaaaccgcc gaataaagat acatattcat 974581 cgcttaagct tgtgccaggc cgcagcagct caaaagctaa aaaggtagat ataaaaacca 974641 aaatcataaa acatacagca gttaatatta tgcgaacggc gccataatcc ttcatgagat 974701 ttatggtctt ccagcaattc atcaaagtca tccttccata catcttgaat agaatctcaa 974761 aataatttac tcctcccaag agaaaaaatc aatgcttttt taagaaaaaa tatcatccgg 974821 caggtatttt tttgaaacaa gcaaacaaac tgcgaaatat ggggttagaa ctttcttctc 974881 agtgaattat cagctaaaat aagattaaag atagaaagaa gtggtgtgga tggattcgat 974941 ggatcatcgc attgagcgat tagaatatta catacaatta ttagtgaaaa cagtagatat 975001 ggacaggtac cccttctatg cgcttctcat tgataaaggg ctgagcaagg aagaagggga 975061 agcggttatg aggatatgcg acgaattgtc ggaagagctg gcaacacaaa aagcgcaagg 975121 atttgtaacc tttgataagc tccttgcgct ttttgccgga cagctgaatg aaaaattaga 975181 tgttcatgaa acaatttttg ccctgtatga gcaggggctt tatcaagagc tgatggaagt 975241 ctttatcgac atcatgaagc attttgatta actgtttaca ggttcgagct cttcagccgg 975301 ttcatccgcc gcactgtcct ttgctttttt cttcaatttt ccgtttacgc tttcaaagtc 975361 attgtcaata ttggtgagtg acgtttcgaa aatttccata aaatcatcgc cgtagatatg 975421 gcgtatcata cacatcattt ctgccacttc aggaaatttt ccgaataaat gatataaagg 975481 ctgtgaccct ttaaaaacag cgttgcgtgt cggatcaaat tcctcaagca agctccagaa 975541 tacctcggta ccttcctcag tcaattggac atatgtgttc cgtttatcat tcagccgttt 975601 ggagaacctt aaatatcccc gttcttccag cttttttgaa aagttgaatg cggttgatac 975661 gtgcatgacc ccgaatttcg cgatttcaga aatggaagct ccattcaatt gatacgcaat 975721 ccataaaata tgatgctcat taatattcag gtcatacggt ttgagccatt gctgccaatc 975781 cttctcgatc gatttccaaa gagccttgct aagctgagcc attttctggg tgaaaaccag 975841 agcttctttc acatcatagg gcggttccac tcgattcatt acgtcacctg cttctctttt 975901 tctttttctc tattatgcca ataaaataaa gattaataaa gatgaaaatg taagaatttt 975961 ttaataaatt cacaaaccat tgcgacgaaa gggtttttcg gccaaaaaaa atacgggtcc 976021 aattttggcc cgcatttttt tcttttgaat aggatattag ttttgtaagg ttttctccag 976081 ctgtctgatt ttctcttcga tatcggcaat ttctttttgc agatcctgct ggtgaggctt 976141 gatctcttcc tgccattttt taattgatgt ttggagctcg ccgcccacgt ctttaataac 976201 atccgtgctt tcttttgccg ctttgatcag ctggtctttt aatgcaagcc cgtctgactt 976261 taagcgtttg attgtttctt caaaagaatc ataattggtt ttcatttttt cacgcagctg 976321 ctttcctgag gaaggtgcag taagaagaac cgctgctcct ccgatgatgc cgcctacgaa 976381 tagtcctgtt aatagagaac gtccgctcgc cattacaatc accccgtctt tttcttcaaa 976441 ataggattca ttcagcattt ttcatttttg ttgaaagcct gaacttctat acatagcttg 976501 ctttatttta gcatattttt taagtgaaaa ggagggagaa ggttgtctgt ctttttgatt 976561 gtattatcct gcatcaccct tgccttcgct tcaggcgctg tttactatat caaacttctc 976621 agccaggctg cttcttatcc gcccaagagg gttatccggc agaaagcgct tgtttgttca 976681 accggaaccg cctttacact atgtcttatc tttttcacaa aactcctcgc ttaaaacatg 976741 ctgacatgct gcgggcgctc tgttcaaaaa aacctctccc ggaagcggaa gaggttttgt 976801 gtgacaatta tttagcagct tccataaagc ttgaacgcct taaaatggtt tgcacaatcg 976861 gataaataat gatcattgag attgtattca gcacagcggc cggcagaaca acagccgcga 976921 acaatgcggc gaaaccgccc ggtaaaccga cgatcaataa agctgacgat agaaacacaa 976981 ttcctgataa gatggtcccg atcactgtca gcacagcggc tgcacctgtt ttccggctct 977041 ttctgaacaa gagaaacagg gagaagaaca gaaacgctga tacgggttta tcaatgatgt 977101 tagggatctg tccggctgga aacgcggttg taagcgcgga aatgattccg gtcacgatcc 977161 cgatgacgag tacattttgc acccgcggga acagcagaat gcccatgaac atcatgatca 977221 gcatcatatc tggtttcatg ccgcctaaaa agggcggaat aatggaatga agcgctgcgc 977281 cgattgcggc aaacagagcc ataatgacta actcttttgt tttcataact atgctctcct 977341 ctgctaagct ttttgccctc caataatatg ctcatcattt attgcgaagg ctttacagaa 977401 tgtgttatgc aaacagtata ccaaacggac ggtttgcata gccagacttt ttactcattt 977461 tcctgctgga atttcttcat gaacgcagct aatttttcac agtcttcgag agagaccgcg 977521 ttataaatag aagcgcggca gcctcccacc gaacggtgtc cgccaaggcc gatcatcttc 977581 gcatcttttg ctttctgaac gaatgttttc gttaattcgt catcccgaag cgtgaatgtg 977641 acattcatgc gtgagcggct gtcttttctg gcatgtcctt tatagaagcc gttgctttca 977701 tcaatacagc tgtagagaac ctgcgctttt tgttcattgc gctgttcaac agcttccaca 977761 ccgccgtttt ccttgagcca ttccagaacg aggctcagca tataaatcgc aaatgtcggc 977821 ggagtgttgt agagtgaatc cgctttgaca tgcgtggaat atttcaagat ttttgggacg 977881 ttcgcatttt cattttgcag ccagcttttt ttcatgatga ctacagtcac gccggaaggg 977941 ccgaggttct tttgggcgcc tccgtagatc acatcaaatt tggacacatc gatttttctg 978001 cttaaaatat cgctggacat gtcggctacg agcggaattg gagaattcgg aaactcctgc 978061 cactgagtgc cgaaaattgt attgttggat gtgatatgta aatatgcgcc gtcttttaca 978121 tccgtaaggt caacctctgg aatataactg taattgtctg tttcacttgt agcggtgata 978181 gacgtgttcc cgaacagttt cgtttctgcc agtgcttttt cagaccaagc gccggtcatc 978241 acaaaatgtg cggttttttc aggtgttaaa aagttcatcg gaagcattga gaattgaagg 978301 cttgccccgc cttgaagaaa caagatatcg taatcttccg gaatgcccat cagttcgatt 978361 aagaggcttt tcgctttttg gtgcaccgct tcatactctt tgctgcggtg ggaaagctcc 978421 ataacagaca tgccggattc gttaaaatca ataaattctt tctgtgcttt ttgcagaact 978481 tccagtggca gcgctgcagg acctgcgtta aaattcgttg tacgttccat tatgatctct 978541 ccctgttttc cacgttaatg tataaaataa tacaattatc ctatcacaaa aattcagttt 978601 tttgataaaa aattagaatt atcaaaagaa attgacggat gtttgcgaaa tgttcacaaa 978661 ataaaataac ctcatcttat gatgaggcca ggcgttttgc gatagaggaa gagatgttct 978721 gcagatcctc cggtttataa tcatcagcat gcgttttcca aaccgctccg aatccatctc 978781 cttttccgta gcgagggata atatgcatat ggtagtggaa cacagattgt ccagcttttt 978841 cgccgttatt gttcagcgta tttaagccga tcggttcaaa ttcatcccgg atagcgcggg 978901 cgatttttgg aacagcatgg aaatattgtt ttgctaattc atctgtaaat tcatatacat 978961 tctcaatatg tgttttcgga atgacaagcg tatggccttt tgtcacttgg ctgatatcaa 979021 gaaaggcaag tacatgttca tcttcataca ccttcgctga tggaatgtcg ccggcaataa 979081 ttttacaaaa gatacaattc tctgcacaat gcatgagggt tcctccttat gaaattgttt 979141 agtatgtata cattcatcgt accacagaaa tgcagaaaat agaaaacagg atgaacggcg 979201 agcgttcacc ctgaatgcag aggaagagct tatatgaaga aaatgtgtta tgcctttggt 979261 aagcacctca tttgtcaata aaatgaagac ttgtttaatg cctaacgatt cctgcgataa 979321 acacctcatt tgacaatttg cttcatacat gaagaattca tcaattcagt gaagagaaat 979381 ggtttgagca ttggacatgt ttattttcta tccaactgtt tctaagacgt ctttgacaaa 979441 cacctcattt ttcagttgat atgcttttcc tctacaactt ttatgatgtc cagaaccctg 979501 tctctttatg acagcaaatt catcatttgt taaaagggaa ttgtttcaaa tcaggccttg 979561 tttttggtac tatgaagaaa aacactataa ggggagaaac tatgtctctg ctatcggtaa 979621 aagacttgac cggcggatat acaaggaatc cggttttaaa aaacgtatca ttcacccttg 979681 aaccgaatca aattgtcggc ttaatcgggc tgaatggtgc tggtaaaagt acaacaatca 979741 gacacatcat cgggctgatg gacccgcata aaggttcaat cgaattaaac ggtaaaacgt 979801 ttgctgagga tccggaaggc taccgttcac aatttaccta tatacctgaa acacctgttt 979861 tatacgaaga attgacgctg atggagcatc ttgaactaac agccatggca tatggactgt 979921 caaaagaaac gatggagaaa aggctgcctc cgctactaaa ggaattccga atggaaaaga 979981 ggctgaagtg gttcccggcc catttttcta aaggaatgaa gcagaaggtt atgattatgt 980041 gcgcattttt ggcagagcct gcgctctaca ttattgatga gccttttcta gggcttgatc 980101 cgcttgccat taacgcgctg cttgaacgga tgaatgaagc gaaaaaaggc ggggcgagcg 980161 tgctgatgtc aacacacatt ttggcaacgg cagaacgcta ttgcgattcg tttattattt 980221 tacataacgg cgaggtgcgg gcgcgcggca cgctgtcaga gctcagagag cagtttggaa 980281 tgaaggacgc ggcgctggac gatttgtatc ttgagcttac aaaggaagac gctggccatg 980341 aataatatgc ttgatatttg gcagtcgcgg ctgcaggagc atatcaaaga aacaagaaca 980401 tacatgaaat atatgctcaa cgatcacctc gtcattgttt tgattttttt tctagcgggc 980461 gctgcaagct ggtacagcaa atggatacgg gacattcccg ctcactttcc gtccttttgg 980521 gtgatggccg tgctgttttc gctcgtattg acaagctctt atgtgcgaac gcttttgaag 980581 gaggctgacc ttgttttctt attgcctctt gaagcaaaaa tggagcctta cttgaagcag 980641 gcgtttgtct acagctatgt gtctcagctg tttccgctga ttgcgctgag catcgttgcg 980701 atgccgcttt atttcgcagt cactccggga gcttcgctcg tatcgtatgc cgcggtcttt 980761 gtccaactgt tgctgctgaa agcgtggaat caggtaatgg aatggcgaac gactttccaa 980821 aacgaccgca gcatgaaacg gatggacgtc atcattcgct ttgcggcgaa tacactcgtt 980881 ctttattttg ttttccaatc tgtttatatg tatgcgcttc tcgtctatgt cattatggct 980941 gttctttatc tgtatatgtc ttccgcagca aaacggaaaa catttaaatg ggagagccat 981001 attgagtccg aattgagacg aaagcagcgt ttctatcgga ttgccaacct gtttactgat 981061 gtgccgcatt tgcgaaagca agccaaacgc agagcttatc tcgacttttt gctgcggctt 981121 gtgccgtttg aacagcgcaa aacatttgcc tatatgttca cccgcgcctt tttgcgttcg 981181 agcgattatt tgggcattct tgtcagatta acgatcgttt tcgcgctgat cattatgtat 981241 gtctcagcca gcccgctgat tgccgcggtt ttgactgtgt ttgccatttt cattacgggc 981301 attcagcttc tgccgctctt cggtcacttt gaccatctgg cgcttcaaga gctgtaccct 981361 gtgcaaaaag aaacaaagct gaaaagctat ttctctctat taaaaactgc acttagtatt 981421 caagcgctgc tgatgtctgt tgcatctgcc tatgcagccg gcttgaccgg ttttctgtac 981481 gcgctgatcg gttctgccgt tctgattttt gttgttttgc ctgcttatat gacgaccagg 981541 ctgaaaaagc acggaaagct gtgaactgaa aagaggtaat caaatgacag ataatcagct 981601 gctgatgcag gaagctttgg aatggaaaat gcattttttg cgaaaggatt ccatgtttga 981661 acgcttttcg aagcgtgtcc agacgaaggt gaatgaacgg attcctgaaa aaatccatac 981721 ggtcgtcacc gagagtgtga aaaaaatggt agaagcgaca atggccggct ctaatatcat 981781 cacctataaa aaggatacaa gtgcactgtc gctcagtgaa aaaaacgaat tggcgaaaaa 981841 aacgattgtt tcttatcaaa aagtggcagc tgctgaggga gtcggcaccg gagcgggcgg 981901 cattttttta agcattgctg attttccgct gctgctttca attaagatga agtgtttatt 981961 taccttgtct tccatttacg gctttgatgt caaggatgca caagaaagga tatttttgct 982021 gctcgtgttt cagcttgcgt tttcgagtga tgatggccgt aagtcgcttt tttctgtcat 982081 cgaaaattgg gagacggaga aaaagagcat cgactggaga gtgttccagc aggaatatcg 982141 cgattatatc gacgtcgtga agctttttca gcttttgccg ggcgtaggag cggcagtcgg 982201 cggaattgcc aattataagc tgcttgctca gcttggagaa acggcaagac atgtttttca 982261 tctgaggata ttaaaggaaa cagccggaga ataaacactc cggctgtttt tttatagctg 982321 atgataggtg atcgcagcgc cggcaaggac cttggccgct gtcagcatgg ctttttcgtt 982381 gatatcaaat ttcggatggt ggtgggaata gactcgctct ggctgttcgg gagcggcgcc 982441 tgtaaagaaa aaagtgccct tcacgttttg taagtaataa gcaaaatcct cgccgcccat 982501 ttgtggttca ccgtcaatga cctgctgaac gccctcggta ttctttgcgg tgctcaccaa 982561 gtggttcgtt tctgcaggat ggttcacaac cgctggataa ccctgttcat aggtgtactc 982621 ataggacgcg ccgtgcatgc tgcatattcc ttttacaacc gcttcaattt ctttctccag 982681 aatgtcccgg acattttcat caaaagaacg cgctgtgccg atgagtactg cttggtctgc 982741 gatgacatta aacggattgt cggcgatgaa ggagcctgtc gaaatgacgg cggattgaat 982801 cggattgact ttgcggctga caatgtgctg caaagaggaa acgatttgcg aaccgattag 982861 gacggcgtct ttagtatcat gcggatgagc gccgtggccg ccctttccga agactttaat 982921 cgtaaatcgg tctgccgccg ccattacggc gccggggcgg cagagaatag ttccgagcgg 982981 ctcagttgcc caaagatgag tgccgaatat cacatccgtg ttttcgagac atccgtcatc 983041 aatcattggc tttgcgcctc caggataata ttcttctgca tgctggtgga tcatcacaaa 983101 tgttcccttc agttcatgtc tgttttggtg aaggaccttg gccactgcga gaagagctgc 983161 ggtgtggccg tcgtggccgc atgcatgcat gacaccaggc actttggagg cgtaagggac 983221 atctttttca tcttgaatgg ggagagcgtc aaagtcggcc ctcaaagcga ctgtagggcc 983281 gggttcgctt ccttctatat ttgctaaaac ccctctaccg ccaacgtttg tgcggattgg 983341 gactcctaac gattcataat aggaagcaat aaatgcggcg gttttttctt cttgaaatga 983401 gagctcagga tacatatgaa aatggcgcct gatctcaacc atttcttcaa aacagccgtc 983461 gagctgtttg tttatctctt tctgcagtgt ggatatggac aaagccgctt cccccttttc 983521 tatgcttttc catgattgta tagaaaaagt ctgaatattt caactcatgc tgttttaaag 983581 catcatcaca gctgcgaggg ttgtcaccaa aaggccaatc gcgacgggaa tgaagttttt 983641 tctggcaagc tcaaaaggat caactttgca aatggccgcg gcgggaatca aagcccatgg 983701 gaccagtgtt cctccgccca cccagatggc agagatttgt ccgagcgcgg tcagaatagc 983761 gggatcggca tggagagcgg acgaaaagag ctttgcgatg gagccggcga gagaaatgcc 983821 agaaaatcct gagccgtcaa ggcctgttat ggctccagcg gcagttaatg cagtggcggc 983881 aagctccttt gacataggca tcatatggga taaagcaatg ccaagatcgt tgacaatgcc 983941 gtgggaacct ttagggagtg aagtgcccag tatgctttca tagcctgagt cgccaagata 984001 aaagaaagcg gcaatcggga tgacggggcc gaaaacctta aaaccgaact taaatccgtc 984061 aataaaatag ccggtgattt tttcaagccc tttatgctta tacacgaaaa aatgaacggt 984121 aaagaggata caaattgcag acccgccaat taacgcggtt gcatcatttc cttgtaggtt 984181 aaacaagagc atgcaggcga tatctgcaag aaaggcaagc ggaatcaaaa aagccagtat 984241 ggaccgcagg cgttttggca agtacagcga gttgtcttgt tcgccggaaa gaacggggga 984301 aaaagaagtg ggatgctcct gttttttgcg ttcgcgctga atcatgataa aggcagcagt 984361 tgttgttgtc acacccataa tcagcacaag cggaatactg gccgagacga catcaccgac 984421 tggaatgcct gctgcatccg cagtcagctt tggcgccgcc tgaatgacaa agtctcctga 984481 cagggcaaaa ccgtgtccga ataagttcat ggccatggcc gcggcaagag gcgtcaaacc 984541 ggcacgtgcg gctgcgggga gcaggacggc gccgatcaaa gcgacacccg gagaaggcca 984601 gaagaataga gaaatggcga acatcaggcc tccaatcagc caataggcag tcacaggccc 984661 tctcacaagg cttgcaaagg gagaaatcat cgcttcattt atccctgttt ttgttaacaa 984721 atcactcatt gaaacgataa agcaaatgat gaaaatcgtg ggcagcagtt cgccggccgc 984781 atagataaag ctgtggaata aactgctgac agaagctgaa agtgaatggc tggcccatag 984841 cgatatgata aaaatgccga atagagaaat aaatgtcgtg tcttttctca gcagcataaa 984901 taggataatt gcaccgataa aaaacacata cagaacatgg acaggcaaaa tcccgacttc 984961 catcatcgat cactccttcc gcttacagat tattcatagg cgggcggaag gtgccgggac 985021 agaggggagg gttatgatgg aagatgaaca ttgatctgtt tcagctgctc aatcagatga 985081 tgccttaatc ctctattcgc tttttgcaga tgttttggga agcattcagg agaaaaaatg 985141 acgcaccctt cagcaagcca gttttttcta taggcgatga tgctttccga tggctctata 985201 tgagttatcc tcgtgctgca tctcgtactc atcaaatccg aactgaaaac cgcagcacgg 985261 gcagatttca tgagaatgat tgccttcatg atcatatggc ggttcagcca atccttaaac 985321 ccgcagactg ggcaagtatg cttcattttg ctttcctccc aataaaataa gctgccggac 985381 atgccggcag ctattcgaca gcgaaatatg tggtgacata ggaaggccgg gagaagatcg 985441 acgttgtgtc aattccggca gatgtatcgc gttttttgtg ggcttctttg taagaaccgg 985501 actgctgcca gtcttgaaag gcgctttccg tttcccacaa ggtcagaatg acataggtgt 985561 cactgtcaag cggacggagc actcgaattg cttcaaagcc aggctcgttt tcgacttttc 985621 ccgctctgtt tttaaatctg ttttcaaaca gcggacgccc ttcctgagta acggcaatat 985681 tgttcaatac tgcaaaaccg ggatgtttga tctctccgac ttggtcaatg acttcataag 985741 cgtgtggtgc ctggaaaacg gtatctccgt ttgtttcatg aattaaaatg gcgttttcct 985801 gcccctgcat caaaaggata ttttctgagg gatgcttctg tacgatcgtt tttaaaaaat 985861 cggctgtccc atatgtaata taaaccttca tatcagccac ctcctgcttg ctagtatatc 985921 aaaacaatgg tataagtttc tattggcgag tgcttcgaac ataattccaa acaatttttc 985981 ccatactacc tttagaaagg cgaggtgagt tcatgtttaa gataaagaaa aagaaacttt 986041 ttatacctat cattatttta gtgttaactg cttttctcgc tttaatagga tatatttcaa 986101 ttatttttct cggccattat gtcatagatg aaaaaaagct tattcttcat gcttcttcaa 986161 aaattgttga tcaaaacgga gatgaggttg caagcctgta tacagaaaat cgcgagccgg 986221 tctcgatcaa tgagattcct aagcaggtca gagaagcgtt tatcgctgtt gaggataaaa 986281 ggttctatga gcatcacggc attgatgcaa aatccgtcgg aagggcagtg taccgcgata 986341 tattagcagg cggaaaggtg gaaggcggaa gcacgatcac ccagcagctt gccaaaaata 986401 tttttctgac acatgacaaa acatttctaa gaaaaacaaa agaagtgatc attgcgatta 986461 atcttgaacg ggattacagc aaggacaagc tgcttgaaat gtatttaaac cagctttact 986521 tcggacacgg ggtttacggc atacaagcgg cgtcccacta ttattttaat aaagaagtaa 986581 aagatttgac tgtatctgaa ggcgctgttt tggccgctat tccgaaggcg ccttctacgt 986641 actctccaat tttgcaccct gataaaaata aggagcggcg tgatacaatt ctaggtatga 986701 tgaatgacca aggctatatc agtgcgaaag aggctgtcac cgcacagggc cggacgcttg 986761 gactgcatgt gaagaaacag tcggaaacac cttggtttga cagctacatt gaccttgtga 986821 tcaaagaggc ggaagacaag tattccattt ccggagagca gcttcttcaa ggcggataca 986881 cgatcaaggt gccgctcgat tcgaagctgc agaagacggc ttaccaggtg atgaaagagg 986941 gaagctatta tcccggaaca gatcagaatg ccgagggaag cgcggtcttt attaataaca 987001 agacaggcgg tgtagaagcg gccatcggcg gaagggatta cacatccaaa ggatataacc 987061 gtgtcacagc tgtccgccag ccgggttcca catttaagcc gcttgctgta tacggaccgg 987121 cgatgcagga aaagaaattt aagccatatt ctctattgaa ggatgagttg cagtcctacg 987181 gagattatac gccgaaaaac tacgacagcc ggtatgaggg cgaagtcact atgtctgacg 987241 ccattacgta cagcaaaaac gcgccggctg tctggacgct gaatgagatc ggcgtcgaaa 987301 cagggaaatc ttatttgaaa gcaaacggca ttgatatccc tgatgaaggc cttgctcttg 987361 ctctaggcgg cttggaaaaa ggcgtttcac cgctccagct tgccggcgcg tttcatacat 987421 ttgccgcgaa tggaacgtat actgaaccct tctttatctc gagcataata gatgaagacg 987481 gagaaacaat agccgatcat aaagaagaag gaaagcgggt attcagcaag cagacgtctt 987541 ggaatatgac gagaatgctg cagcaggtag tcaaaaaggg aacggccacg tccggcacct 987601 atcacggcga cctggcggga aaaacaggtt caacatctta tacaggcgtc tccggcgcga 987661 caaaggacgc ctggtttgca ggctatacgc cgaaaataac cggggcagtc tggatgggct 987721 atgacaaaac ggatcaaaac cattatttga aagccgggag ctcatacccg acgcggctgt 987781 ttaaggatat tttgacacag gcaggagaaa ccggtcatgt gttcacaaag cctaaaaacg 987841 ttaaagaact ggaaagcccg attgagctga agccggtcaa aacactcaca gccgattaca 987901 catttaaagc agcggggctc tttactattg aattaaagtg ggacgctcaa gaggatgatc 987961 gggccgtata cagaatttat gtaaacaagg acggcgagga gacgcttctt gattcggttg 988021 aagggaaggg aagctatgaa attccttatg ccaacttatt ttcgggcgcg tcttataaaa 988081 ttgtgcctta taatacacag acaaaaagag aaggggaagg aaccgattac gttcagccaa 988141 aattgttttc ctcttaatgg aattcggcga ttttttgaac tttgagctac atttctatac 988201 catttgccta aaacaaggta tagtgtaata agtcaagaaa tacgaacgta tggttgccgt 988261 atgaaaggtg gaaatcagat gagtaaacga gaaacgttta acgagacgtt tttaaaagct 988321 gcgcggggag aaaaagcgga tcacacgcct gtgtggtata tgaggcaagc agggcgctca 988381 cagccggaat accgcaagct gaaggaaaag tacggattgt ttgagatcac acatcagccc 988441 gaactttgtg cgtatgtcac aagactgccg gttgagcaat acggagtcga tgctgcaatc 988501 ctttataaag atatcatgac gccgctgccg tcaatcggtg tggatgttga aatcaaaaac 988561 gggatcggtc ctgtgattga tcagccaatc cggtctctgg cggacattga aaaactcggc 988621 cagattgatc cggaacagga cgtgccgtac gtgcttgaga cgattaaact gcttgtcaat 988681 gagcagctga acgtcccgct catcggtttc tcaggtgcgc cttttacgct tgcaagctat 988741 atgatcgaag gcggcccgtc gaaaaactac aataaaacaa aagccttcat gtacagcatg 988801 ccagatgcat ggaatctgct gatgtccaag cttgccgaca tgatcatcgt gtacgtgaaa 988861 gcgcagattg aggcaggcgc aaaagcgatt caaatctttg attcgtgggt cggcgcattg 988921 aatcaggcag attacagaac atacatcaaa cccgtgatga accggatctt ttcagagctc 988981 gcaaaggaga atgtgccgct gatcatgttt ggcgttggcg caagccatct tgcaggtgat 989041 tggcatgacc ttcctctcga tgttgtcggg cttgactgga gactcggcat tgatgaagcc 989101 agatcaaaag gaattactaa aacagtgcag ggcaacctgg acccgtccat tttgcttgcg 989161 ccatgggaag tcattgagca gaaaacgaag gaaatacttg atcagggtat ggagtcagac 989221 ggcttcattt tcaatcttgg ccatggggta tttcctgatg tcagtcccga ggttttgaaa 989281 aaactgacag catttgtcca tgaatattca caaaacaaaa aaatgggtca atattcctaa 989341 gcatatcttt tggtatctta atgatatcct gtcaaaatgt ttgtatcaga tcattaaaga 989401 gggtgtaaac agtgagtaga aagaaaatgg ggcttctcgt gatggcgtac ggcacgcctt 989461 ataaggaaga agatattgaa cgttattata cacatatcag aagaggcaga aagcctgaac 989521 ctgaaatgct tcaagatttg aaagacagat acgaagcgat tggcggcatt tcaccgcttg 989581 cccaaatcac agaacagcag gcgcataatc tggaacagca cttgaatgaa attcaggatg 989641 agattacgtt taaagcgtat atcggactga agcatatcga gccgtttatt gaagacgccg 989701 tagcagagat gcataaggat ggcattacag aagcagtcag catcgtgctg gcgccgcatt 989761 tctccacgtt cagcgttcag tcctacaaca aacgcgccaa agaagaggct gaaaaactcg 989821 gcggcttaac gattacgtca gttgaaagct ggtacgatga accgaagttc gtgacatatt 989881 gggttgaccg agtgaaggaa acatatgcgt caatgcctga ggatgaaaga gaaaacgcaa 989941 tgctcatcgt atccgcacac agcctgccgg aaaaaatcaa agaatttgga gacccgtacc 990001 cggaccagct tcatgaatcg gcgaaattaa ttgctgaagg cgcaggcgtt tccgaatatg 990061 ctgtcggctg gcaaagtgaa gggaacacgc ctgatccttg gctcggaccc gatgttcagg 990121 atttaacacg tgatttattc gaacaaaaag gctatcaagc atttgtatat gttcctgttg 990181 ggtttgtcgc ggatcactta gaagtgcttt atgataatga ttatgaatgc aaagtggtta 990241 ctgacgatat cggcgcaagc tattaccggc cggaaatgcc aaatgccaag cctgaattta 990301 ttgatgcttt ggcaacagtc gtattaaaaa aattaggacg ttaaagaagg cgatgaacat 990361 gagtgacggc aaaaaacatg tagtcatcat cggcggcggc attaccggtt tagccgccgc 990421 cttctatatg gaaaaagaaa tcaaagaaaa gaatctgccg cttgagctga cacttgttga 990481 ggcaagtccg agagtcggcg ggaaaatcca gactgtcaag aaagacggct atatcatcga 990541 aagagggcca gactcatttc tggaacgaaa gaaaagcgcc ccgcagcttg ttaaagactt 990601 aggtcttgag catttgcttg tcaacaatgc gaccgggcaa tcctatgtgc ttgtaaaccg 990661 caccctgcat ccaatgccga agggcgctgt aatggggata ccgacaaaaa ttgcgccgtt 990721 tgtttctacg ggtctgtttt ccttgtccgg gaaggcgaga gctgctatgg atttcatcct 990781 gcctgcaagc aaaacaaagg atgatcagtc attgggagaa ttcttccgca gacgtgtcgg 990841 agatgaagtg gtcgagaact taatcgagcc gctactatca gggatctacg caggcgacat 990901 tgacaagctc agcctgatgt cgacatttcc gcaattttat cagacggaac aaaagcatag 990961 aagcctgatt ctcggcatga aaaaaacaag gcctcaaggc tcaggccagc agctgacggc 991021 aaaaaaacaa gggcagttcc aaactctgtc aaccggtttg cagacccttg tagaagagat 991081 cgaaaagcag ttaaagctga cgaaggtgta taaaggcaca aaagtgacca aacttagcca 991141 tagcggctct tgctattcgc tcgaactgga taacggcgtc acacttgatg ctgattcagt 991201 aattgtgact gctccgcata aagcggctgc gggaatgctt tctgagcttc ctgccatttc 991261 tcatttgaaa aatatgcact ccacatccgt ggcaaacgtc gctttaggtt tccctgaagg 991321 ctccgtccaa atggagcatg agggcacggg ttttgtcatt tcaagaaaca gtgactttgc 991381 gatcacagcc tgtacgtgga cgaataaaaa atggccgcac gcagcgccgg aaggcaaaac 991441 gctgcttcgg gcatatgtcg gaaaagccgg agacgaatcc attgtcgatc tatcagataa 991501 tgacattatc aacattgtgt tagaagactt aaagaaagtc atgaacataa acggcgagcc 991561 ggaaatgaca tgtgtaaccc gatggcatga aagcatgccg cagtaccatg tcggccataa 991621 gcagcgtatc aaggagctgc gtgaagcact tgcatctgcg tatccgggtg tttatatgac 991681 aggcgcttct ttcgaaggtg tcggcattcc cgactgcatt gatcaaggaa aagctgccgt 991741 gtctgacgcg cttacctatt tattcagcta aaacctccgc tttatcgcgg aggttttttt 991801 gatgtgcaat ggcaatattg tgtaaaaaat gattgaattg aacagcaggt tatgatacat 991861 ttgcatatgt acttaatgac taaaatgttc aaacggtcag tttcgaggtg aatacaatgt 991921 caatagatcg aaaaaagctc attttggagg cggctacaaa gtctttcacg cagttcgggt 991981 ataaagcgac gacaatggat cttgtcgcaa aacttgcgaa cgtggggaag ggaaccattt 992041 atactttttt caaaaacaaa gaagagctgt ttgacgagat tttcactact ttattaaagg 992101 aaatgaagca aaaagcggat gaagcgatgg agccgagcct tccgttccat gaaaatgtgc 992161 acagagcgct gtttgccatt ctggagttca ggaaaacaca tcagctgacg attaaaattt 992221 tccaagagaa tgccgagatt ggtacaatgg cagttcagga agtgatccag aaaatggagc 992281 gatccatcct gtcttatatc aaaagcaaga ttgaagacgg gatcaaaagc ggcgcaatca 992341 agccgtgcga ccctgagctg acagcctttg tgatgctgaa gctttatatc gcgctcattt 992401 ttgactggga aaaacaacac cccccgcttg ataaagagac aattgcggga ctgcttgaat 992461 tgtatgttgt caaaggattg tcagcgaact agataatcct ttctctttgc aagaaaatga 992521 ccatttttta tgatgagtca gttttagaat ggaggcatca ggatgaacac aatacgaagt 992581 cagtggaaag acatcgtaac aagtaaaaaa ttattgattc ccatcatcgc cattttgttt 992641 gtcccgctta tttacagcgg cgtattctta aaggcttatt gggacccgta cggcacagtt 992701 gaccagctgc ctgtcgttgt cgtcaaccaa gacaagggag caacgtatga aggagaaaaa 992761 cttcaaatcg gtgatgatct ggtcaaagaa ttaaaggata ataacaactt tgattggcat 992821 ttttccaatg atctcgacca atcgttaaag gacttattga atcaaaaata ttatttagtt 992881 gtcgagattc ctgaggattt ttctaagaat gccagcactg tattagacaa aaatccgaaa 992941 aaattggatc tgaaatacca tacaaatgca ggttctaact atgtaggggc aacgatcggc 993001 gaaaaagcga ttgataaact gaaagcctct gtttcaaaag aagtgaccga gcaatatacg 993061 aaagttattt ttgataactt taaagatatc gcaaaaggtt tgagcgacgc gagcagcggc 993121 gcgaaaaaaa ttgatgacgg cacaaaggat gcgaaaaacg gaagcgccca gctgaaagaa 993181 aatctggcga agctgaagga aagcaccgct accatcagtg acaaaacagc gcagcttgca 993241 gatggagcgg ctcaggtgac gagcggcatc caatcacttg acagctcgct cggtaaattc 993301 caggacagca gcaaccagat ttatgataaa tctagtcagc ttgcagcagg atcaggcgag 993361 ctgacaagca agatgaatga acttcttgcc ggacttcaaa atgtgcagaa gggtacgcct 993421 aatcttacta acgggttgga tcagctcaac agtaaagtcc aagaaggttc tgagaaagcg 993481 gcaaaagcgg aaaagatcat taatgcgctc gatttaacga agcttgaaac tgctgtaaac 993541 aatctggaaa agtcagaaac tgcgatgaag gaattcaaaa aacagctgac tgactttgaa 993601 aacagtttga aaaaccgtga tcaggcattt aaaaatgtca tcaattcgag tgacttctta 993661 acagcggagc aaaaaagcca gctgattaat tctgttgaga aaaagcttcc gcaagttgat 993721 gcgcctgatt ttgatcaaat attaagccag ctacctacag ctgatcagct gcctgacatc 993781 gcaacgataa aaagctctct tgaagacgtg aaagcgcagg tggcgcaggt gaaagccatg 993841 ccggaagcta catctaagct ttataacggc gcaaaaacaa tccaagatgc gattgacaga 993901 ttaactgagg gagctgataa gatatacaac ggttctcaga agctgacaga tggccaaact 993961 aaactgacag cgggcatcgg tgaatataat aagcagttcg caaaagcaaa agcgggctca 994021 gagcaattgg tgacaggaag cagccaagta tccggcggat tgtttaagct gttagacggg 994081 tctaaacagg tccaaagcgg atcatcaaaa cttgcagacg gatctgcatc acttgataca 994141 ggtttaggca agctattgga cggcacagga gagctgtcta gtaagctgaa ggatgcggct 994201 gaccaaacag gagatatcga tgctgatgat caaacatacg gcatgtttgc ggatccggtt 994261 aaaaccaaag atgatgccat tcattccgtt cctaactatg gaacagggct gacaccttat 994321 atcctgtcaa tgggcttgta tgtcggcggc atcatgctga cggttgtctt cccgctgaag 994381 gaagcgtcag gacgtccgag aaacggtttt gagtggttct tcagcaaatt caatgtcatg 994441 atgcttgtag gaatcattca atcattgatt gtggcgacgg ttcttctatt gggaattggt 994501 cttgaggtag agagcacgtg gagattttac gtgtttacga tcattacgag tctcgctttc 994561 ctggcgataa ttcaattttt ggctacaacg atgggcaacc cggggcgatt tatcgcagtc 994621 attattttag tgctgcagct gggagcgagc ggaggaacct tcccgctgga attgcttccg 994681 aatttctatc aggtcatcca cggcgcattg ccgatgacct acagcattaa cggattcaga 994741 gcagtcattt caaacggtga ctttggctac atgtggcaga tggccggcgt cttaatcggc 994801 attgccctcg tcatgattgc actaagcatt acttacttta caatgttaag ccggaaggaa 994861 gaaacatcag aagaacagcc ggcttcataa agaaaaagaa cttgtttcct tggaaacaag 994921 ttcttttttt gttacatccc ccatttaata agcaatcctg tataggttaa tccgccgcca 994981 aacccgaaaa gcaaaacgat ttgatctttt ttcagcttcc cggctttcac tgcgagatcg 995041 agcgccaaaa caattgaaac cgaagacgtg tttccgtagt gctcaacact agtgagcgtt 995101 ttttcaatcg ggaacggtgt tttttcacaa attgactcga tcatgcgcaa gttggcgctg 995161 tgaggaacaa accaatcgag atcatcggag ctgagtcctg ctttatgtaa aagccgttca 995221 aattcgccag ggacggttct tgcggcccat ttatatacct cgcgtccgtt ttgcaccatt 995281 tttccggaac cgacaagctg cacaccgttt atttcatttc gcagtccggc acgatacaaa 995341 atatcgccgc cgttcccgct tgttccttgt acagacgcaa gaaatcccgg cgtctcttca 995401 tctcgttcta ctaacagcgc acccgcggca tcgccgaaca gtacgcatgt cgttcgatcg 995461 gtataatcgg ttacctttga taacgtctct ccggcgatga cgagaatttt ttgatgaagg 995521 ccagatgtga tcaatccatt tgccaaatgg aggccgtatg tcagcccggc gcatgtcgca 995581 ttaatatcca gcgcgccggt gctttcccag ccgaaatatt cctgtacgcg gcatgccgta 995641 ctcggaaagg cgtaatcgga tgtggttgtg gcaacgagga tcatatcgac atcatcaagc 995701 gttcctttat aacggctctt gagattcttc accgcttcta tgcataaatc agaggtaaat 995761 tgatgttcat ccgcaatccg gcgttctctc attcctgtgc gctgaacgat ccattcatca 995821 gaggtatcaa cgatcttttc taaatctgca ttggttaaac gtctgctcgg cgcataggtg 995881 ccgatagctg taatttttgc ttttgacata tgaatcactc cttatggtca gattataaca 995941 ctagatatta gtatctggta ctaaaaagaa ggttttttta caaaaaaaga gaagtgtaga 996001 taggaatcta tgaaaaagaa aaaggaggct gaaaaatggt cagtcaagaa gcagtagtct 996061 ttttggcatt atccggggct attgcgtttc tgttgccaat cgggctgatt gtatggttta 996121 agcgaaagta tggtgcctcg cttaaagtgt tttttattgg cgctctcacg ttttttgtct 996181 tcgctcagct gctggaaggc ggcgttcatg tttatgtact gcaagtgaat gaaatgacga 996241 aagaagcgat gcagcatcca ttatggtatg gcatttacgg ctgcttgatg gccggcattt 996301 ttgaggagtg cggaaggtat ttgatgatgc gattttttat gaagcgccat catacttggg 996361 cagatggtct ggctttcggg gcaggccatg gcgggcttga agccatcctg attacaggct 996421 tgtcctctat ctcacttatt gtatacgcat ttgcaatcaa tagcgggacg tttgaacagc 996481 ttttggtcaa tggcgacgtc aaacaggcgc ttttgccgat acaggagcag ctgctgcata 996541 ctccttcgta tgaatggatg ctgggcggaa tagaaagaat cagtgccatt gccgtccaga 996601 ttggtctgtc tctgcttgtt ttgtacgcgg ttaaaaaccg ccggccgctg tttttgctgt 996661 attctattct tttacatgca ctgtttaatg tcccggcggt tttatatcaa agaggaatca 996721 tagagcatgc tgcagctgtt gaaatcattg ttgctcttat agcggcttta tcagtttatt 996781 ggattgtaaa agcaaaaagg gtgtttcaat aaaaggtcca agcagcagca atgcccgctt 996841 ggaaaaatgt gaatggaaat attcattaag catgggtcat cagaatattt ctgattcagt 996901 ctttagcaat gacagcaaga atgtctgtgt tttttacaag agaaacaatg gtgtttcttt 996961 ttcttcttct cgcaagggtc atggcattct ttctttttct tgcaatggtc gtggaaatct 997021 ttatcgaacc actcgtcaaa gaaccaaaaa tcatcgaacc aatcgtgaca acgacatttc 997081 tgttcatgtg aatgacgaca gcacatagaa atccctcctc ttcccatgct ctctacagca 997141 tatgagagat tgataggaaa agattggacg ggtccctcgg gaaaagagta tattttaagt 997201 agaaaataaa aggaggaatg ccctatgacg tccgtacgta aaacgatgga gctcattaaa 997261 gaacttgtat cgatcccaag cccgacagga aatacatatg aggtgatcaa ttatattgaa 997321 agccttttaa aagaatggaa ggtagaaacg gttcggaacc acaagggcgg cttaattgca 997381 acgcttccag gacgcgacac atcccggcat cgcatgctga cagcgcacgt tgacaccctc 997441 ggcgctatgg tgaaggaaat taaagcggac ggccggctga aaatcgactt aatcggcggg 997501 ttccgctaca actcgattga gggggagtat tgccaaattg aaaccgcctc gggaaaaatg 997561 tacacaggca caatcttaat gcatcaaacg tctgtgcacg tatacaaaga cgcgggaaag 997621 gctgagcgga atcaagagaa tatggagatc cgcctagatg aacctgttca ctgccggaaa 997681 gatacggagg agcttggcat tggcgtcgga gactttgtgt cgtttgatcc acgtgtcgag 997741 atcacatcaa gcggatttat taaatcgcgc catttggatg acaaagcaag cgtcgcctta 997801 ttgctccgct taattcatga aattcaaaca gaagacattg agctgccgta tacaacccat 997861 tttcttattt ccaataatga agaaatcggt tacggcggga attcgaatat tcctcctgaa 997921 acagttgaat atttggcggt tgatatgggc gctatcggtg acgggcaggc gacggatgaa 997981 tattcagtat caatctgtgt gaaggatgcg agcgggccgt atcattatca gctcagaaag 998041 catttagttc aattagccga gaagcatcat attgactata agcttgatat atatccgtac 998101 tacgggtctg atgcgtcagc agcgatcaaa tccgggcatg atattgtgca tggcctcata 998161 gggccgggaa ttgacgcttc ccatgcattt gaacgcaccc ataaatcatc tcttcgccat 998221 accgctaagc ttctgtatta ctatgtacag tcaccaatgg tataaggggg aggaccaatg 998281 aagatttata agctgaaaag cacattcggt tgggaaggtg atgacgggtt gggagaacag 998341 ctgattcagc agatccttgc cggagaaaaa agcgccacgt gcgcgccgaa atcattgtat 998401 tcaaaagatg aattgaggga cgtttatcaa acagcgggtc agcttgttac cgtttatgat 998461 aaacatgaca atccaagatg caatataaaa gtaacagatg tctttgaaac cacctttggt 998521 gcgcctgata tgaggttagt caaaggagag ggcaatggag accgaattga ggagtttcaa 998581 gaggatcatc ggatggcatg ggcggaactg atcaaaagcg gtgaactgga gctgaatgag 998641 gatactgttt tgattacaga gttgtttgtg cttgttaaag attaaaaaag cctgcggggc 998701 aagaaccccg caggcttttc attaaccaga aatggttgcg ttttgttctg ttttcgattg 998761 ggacataaca gtttctgctt tcgcaggatt aaacatgcct tcccatttag acatcacaac 998821 ggcagcaagc gcgttaccag tcaggttgac aactgtacgt gccatatcca tgatgcggtc 998881 tacgccggca ataaaggcaa gtccttcagc cggaacgccg atggtgccaa gcgttgcaag 998941 caagacaaca aaagaagtac caggtacggc agccatccct ttggatgtca ccattaagac 999001 gagcacaagc gtaatttggt gccaaatcgt caaatcaatg ccatatacct gtgctaaaaa 999061 gagtgcggca atagattgat agagaacgga accgtctaag ttaaacgtgt aaccgatcgg 999121 aatgacaaat gaaacaatgc cttttggaca tccgattttc tccatttttt ccatgatacg 999181 cggaagaacc gtttcagagc tggacgtact gaacgccagt aagatttcgt ccttcatgta 999241 agcaaggaac ttgaagatgc tgatgccggc aatttttgcg acaatcccga aaataacaat 999301 taagaagaaa gcaagcgcga cataaaccaa tccgacgagc tttccgagag agataagaga 999361 accgagtccg aatttagaca cagtcactcc gataagagcg aaaacgccga atggcgccac 999421 tttcatcaca aggtttacaa cgtggaacat ggcatgggat acaccttcaa aaaaggctaa 999481 tacaggcttg cctctttcac cgatcgcgga aatacccaat gcaaatagta ctgtaaagca 999541 gatgatggct agaagatccc cttcgaccaa tgactggaag aagtttgtcg gcacaatatg 999601 gaggaacgtt tccgccactg atttattact ttgttctttt tcagtttcaa catattgact 999661 gatgtccgat ttttgagctt cgtgtatatt aactcctgta cccggatgga agatgtttgc 999721 aagggctagt ccgagaataa tggcaaaagt cgtgatgatc tcgaagtaca gaatcgttct 999781 gaagcctaat ttaccgactt gctttccatt tcctgcaccg gctacaccga tgattaagct 999841 ggagacaaca ataggaatca ctatcatttt gattaagcgt aaaaagagat ccccgattgg 999901 ctgcaggtaa gtaggcaatg ctgggttgcc ataccaaatg acgccaacaa tgacacctag 999961 aataagtcca acgaatattt gtgtggctaa tccaaactta attcttttca tagattacct 1000021 cccaaaaaac aaagtatcaa catatatcat gaatagacat atatttaatc tcactattag 1000081 atcaaattat aatagataag aaatcaattc gtctatagta aattatattt cgaaaataaa 1000141 gaatattcaa tgacattatg ataatcacca gaattatcta aaaacaggtg agctttgacc 1000201 taacctgact attatttcaa aattaagaga tatgtgaaaa aataagaaaa tcccacgcgt 1000261 aaggcgcggg attttcgctc attacaaatc gtttactttt atacagtcat tgcagatatt 1000321 accataacac tcatgctgct cttctatctt ttttccgcat tccgcacact ttttcgaagg 1000381 caggtttcta aaaaattctg tgattttccc cagcataacc aatccctctt tcccctttgt 1000441 agtgatttca ttgtaatata acagattaca aaaatcaata actgttttga tacaatgttt 1000501 aaaacatgct tttttcaaga aaaatgggta tattgaagga ggaccaattt ttttgaaaag 1000561 ataggaggac attatgaaag ttacagttat cggatgctat ggcggttttc cggccgcaaa 1000621 tgaagcgacg tcaggctatt tgtttcagtc aggtgattac tctctgcttg ttgattgcgg 1000681 cagtgccgta ttgtctaagc tgttcggata tgtgccggcg gaaaagctgg atgcggtcgt 1000741 tctgtctcat tatcaccatg accatatcgc tgatatcgga ccgctgcaat ttgccaagca 1000801 agtcggttcg tttctcggca aaggagagca tacgcttccg atttacggac atgatgctga 1000861 tatagaacag tttcaaaagc ttacatataa aacacataca aaagggatcg cctatcagcc 1000921 ggatcagccg ctgactgccg gtccgtttac gatcaccttt ttaaaaacga ttcacccggt 1000981 gacgtgctat gccatgcgga ttactgacgg cagccacact gtcgtttata ctgctgattc 1001041 cagctatcag gattcattta taccgttttc gaaagatgct gatttattga tctcagaatg 1001101 caatttttat gccgatcaag acggaacaag tgcaggccat atgaacagcc tggaagctgg 1001161 gcgcattgca aaagaagccg gagcgggaga actgctgctg acacatttgc cgcattttgg 1001221 cgtgcatgac aaccttcgca aagaagcgaa aaccgttttt aacggagaag tgaatattgc 1001281 gaaatcaggt tttgtgtggg aaggataaag gaggagcacc atgttattta tagacaatca 1001341 aaatatcaat gatccgcgga tcaatcttgc tatcgaggag tactgtgtaa agcatttaga 1001401 ccctgaacag caatatttgc tcttttatgt gaatcaaccg tctattatca ttgggaaaaa 1001461 ccaaaataca atagaagaaa tcaatacaaa atatgttgag gaaaacggga ttatcgtcgt 1001521 ccgccgttta tcaggcgggg gcgctgtgta ccatgatctg gggaacttga acttcagctt 1001581 tattaccaag gatgacgggg acagctttca taactttaaa aaattcactg agccagtgat 1001641 tcaggcgtta catcagcttg gggttgaagc cgaattaagc ggccggaacg acattgtagt 1001701 agatggccgg aaaatatccg gaaacgctca gtttgcaacg aaaggccgta ttttcagcca 1001761 cggcaccctc atgtttgatt cagccattga tcatgttgta tcagcattaa aggtgaaaaa 1001821 ggataaaatt gaatcaaaag gcatcaaatc gatcagaagc cgagtggcaa acatcagtga 1001881 gtttctcgat gataaaatga ccaccgaaga attccgcagc catttgcttc gccatatttt 1001941 taacacaaac gacgttggaa acgtgccgga gtataagctg acggaaaaag attgggagac 1002001 cattcatcaa atttcgaaag agcgctatca gaattgggat tggaactacg gccgctcacc 1002061 aaaatttaac cttaatcatt cgaagcgtta tccggttgga tcgatcgatt tgcacctgga 1002121 agtcaagaaa ggcaaaatcg aggactgcaa aatcttcgga gatttcttcg gtgtcggtga 1002181 tgtatctgaa attgaaaacc tgctggtcgg aaaacaatac gaacgcagcg tcatcgctga 1002241 tgtgctcgaa ggtgtgaatc tcaagcatta ctttgggaac attacgaaag aggatttcct 1002301 tgatctgatt tactaaggca aaacacatcg tttgaaagag cggttgtgtt tttgaaataa 1002361 tggaggcagg agggattcac atgaaagtgt ttttaatcgg agcgaacgga caaatcgggc 1002421 aaagactcgt ctctttattc caagataatc ctgatcattc catcagagcg atggtcagaa 1002481 aagaagaaca gaaagcgtct cttgaagctg ccggtgcaga agctgtgctt gcgaatctgg 1002541 agggcagccc ggaagaaatc gccgctgcgg caaaaggttg tgacgcgatc attttcacag 1002601 ccggttccgg cggcagcaca ggctatgata aaacgctgct ggtggatctt gatggagcgg 1002661 caaaagccat tgaagctgcg gccattgccg gaatcaaacg gtttattatg gtcagcgccc 1002721 tgcaagccca taaccgtgaa aattggaatg aggcactcaa gccttattat gtggccaagc 1002781 attatgctga taaaattctg gaagcgagcg gtttaaccta tacgattatc cgtccgggag 1002841 gccttcgcaa tgagcctgga acgggaactg tttcagcagc gaaggatctg gagcggggat 1002901 ttatttcccg tgatgacgtt gcaaaaacgg tcattgcctc tttagatgag aagaatacgg 1002961 aaaatcgggc ctttgatctg acagaaggag atacgccgat tgccgaagca ttgaagaaac 1003021 tatgacagta ctgacactca gggctttttg ctcttgagtg tttttttctg tttctctata 1003081 atggagaaga aagcttggct tcaataatga atgactattc attcacttaa ggggtgggag 1003141 aatgaatctt gtttcaaaat tggaagaaac agcatctgag aagcccgaca gcatcgcatg 1003201 caggtttaaa gatcacatga tgacgtatca agagctgaat gaatatattc agcgatttgc 1003261 ggacggcctt caggaagccg gtatggagaa aggggaccat ttagctttgc tgcttggcaa 1003321 ttcgcctgat tttatcatcg cgttttttgg cgctttaaaa gctgggatcg tagttgttcc 1003381 catcaatccg ttgtacacgc cgacagaaat tggttatatg ctgacaaatg gcgatgtaaa 1003441 ggcaatcgtg ggcgttagcc agcttttgcc gctttatgag agcatgcatg aatcgctgcc 1003501 aaaggttgag ctcgtcattt tatgccagac gggggaggcc gagccggaag ctgcggaccc 1003561 agaggtcagg atgaaaatga caacgtttgc aaaaatattg cggccgacat ctgccgctaa 1003621 acaaaaccaa gaacctgtac ctgatgatac cgcggttatt ttatatacgt caggaacgac 1003681 tggaaaaccg aaaggcgcga tgctgacaca tcagaatttg tacagcaatg ccaacgatgt 1003741 cgcaggctat ttgggaatgg atgagaggga caatgtggtc tgcgctcttc ccatgtttca 1003801 cgtgttttgt ttaaccgtct gtatgaatgc accgctgatg agcggcgcaa ctgtattgat 1003861 tgagcctcaa ttcagtccgg catctgtttt taagcttgtt aagcagcagc aggcgaccat 1003921 ttttgccggt gtgcctacaa tgtataacta cttgtttcag catgaaaacg gaaagaaaga 1003981 tgatttttct tcgatccggc tgtgcatttc gggaggcgcg tccatgccag tcgcgttgct 1004041 gacggcgttt gaagaaaaat tcggtgttac cattttggaa ggctacgggc tctcggaagc 1004101 atcacccgtc acgtgcttta acccgtttga caggggcaga aagccgggct ccatcgggac 1004161 aagtatctta catgtcgaaa acaaggtcgt agatccgctc ggacgcgagc tgcccgctca 1004221 ccaggtcggc gaattgatcg tgaaaggccc caatgtgatg aagggctatt ataaaatgcc 1004281 gatggaaaca gagcatgcat taaaagacgg gtggctttat acgggggact tggcaagacg 1004341 ggatgaggac ggctattttt acattgttga ccggaaaaaa gacatgatca ttgtaggagg 1004401 atacaatgtg tatccgcggg aggtggagga ggtgctgtac agccatccgg acgtcaagga 1004461 ggcggttgtc atcggcgtgc cggaccccca aagcggggaa gcggtaaagg gatatgtggt 1004521 gccgaaacgc tctggggtaa cagaggagga catcatgcag cactgcgaaa agcatctggc 1004581 aaaatacaag cggcctgccg ccattacgtt tcttgacgat attccgaaaa atgcgacggg 1004641 gaaaatgctc agacgggcac tgagagatat tttgccccaa taaaatgaaa aagcgaagcg 1004701 gttagcttcg ctttttcatt ttcaatcctt tgcttctttt ttaataatat ttagcagcgc 1004761 ctttgtatca tttttgctta atttgtagta tgtgccatcc ttcaaaaaaa cggcttgctg 1004821 gctgccgtca atccatagtc tgaatgagtc ataccggtct ttatgaaact tgattgtccc 1004881 ttcgtaatca ggggctgatg ttttttctgt cttcacctgt tttccctgat tcataatatc 1004941 cagcatatct ttgacgtgct gtcttttttc aatctcgata tcttcctggc cgcttgaaga 1005001 cagtgtgatc aaatccgcgt ctaccgattg atacacatcg cctgatcggc tgtaaagata 1005061 aaaaaatgcg ataaacacaa gaccgattac cacgatggct gccactattt ttttcatttg 1005121 catcactcca aacattgtta gttttcccag cgatcggggt ttccatgctt aaaagggtgg 1005181 aaaagtgcgg aacacagctt ggttctaaga atttgaattt atgattacaa tagaagtaac 1005241 gggttgatgt gaggagtgag gcgttatgcg caagtggatt gcggcagcag gacttgctta 1005301 cgtgctgtac gggctgtttt tttattggta ttttttcctg tcgggtgatt ccgcaatacc 1005361 ggaagccgtg aaagggacgc aggctgatcc ggcttctttc atgaagccgt ctgagttggc 1005421 agtggccgag cagtattcga atgtcaagaa ttttttattt tttatcgggg taccacttga 1005481 ttggtttctg ttttttgttc tgcttgtcag cggtgtttca aagaaaatca agaaatggat 1005541 cgaagcggcc gtgccttttc ggtttttgca gaccgttggt tttgtgtttg tgctttcgct 1005601 gattacaaca ttggtgacgc tgcctttaga ttggataggc tatcaagtat cgcttgacta 1005661 taacatttcc acacagacaa cggccagctg ggctaaggat caggttatca gcttttggat 1005721 cagctttcca atctttacgc tttgcgttct cgttttttat tggctgatca aaaggcatga 1005781 aaaaaaatgg tggttatacg cctggctgtt aacagtgccg ttttcgctgt ttctgttttt 1005841 tattcagccg gtcattatcg atcctttata caatgatttt tatccgctga aaaacaaaga 1005901 gcttgaaagc aaaattttag agctggcaga tgaagccaat attccggctg accatgtata 1005961 tgaagtgaac atgtcagaaa aaacaaatgc gctgaatgcc tatgttacag gaattggggc 1006021 caataaacgg attgtattgt gggatacgac gctgaacaaa cttgacgatt cagaaattct 1006081 gtttattatg ggccacgaaa tgggccatta tgtcatgaag cacgtttaca tcggtctggc 1006141 tggctatttg ctcgtgtcgc tcgccggatt ttatgtcatt gataagcttt acaagcggac 1006201 ggttcgccta acccgcagca tgtttcattt agaagggcgg catgatcttg cggcacttcc 1006261 gctgttattg cttttgtttt ctgttttgag ctttgcggtt acgccttttt ctaatgctgt 1006321 ctcgcgttat caggagaata aggctgacca gtatgggatc gagttgacag agaacagaga 1006381 agccgctgtt aaaacgtttc aggatttggc cgtgacgggg ctgagccagg ttgatcctcc 1006441 ggtgcttgtg aagattttca gaggcagcca tccgtcgatc atggaacgga ttcaacatgc 1006501 ggagaaagaa gagaatgcgc cggaacatca ggatgctgac aaataaaaag aagcaggtat 1006561 ggaggaacct gcttcttttt actattattg tgcagctgct tgtacgttga ttaacccttt 1006621 tccatagtag aaagagtttc caagatatgt tgcagtgctt tctaaacgat cacggacttg 1006681 cgcgtttgtc caagtcgggt gcttagaaag aattaacgct gctgctccgg caacgtgagg 1006741 agtcgccatg gacgttccgt tataagcgcc gtaagtgcct ccaggaagtg tgctttggat 1006801 ggacacgcca ggagccatca catcaagctc agaacctgcg ctggagaatg aagctctttg 1006861 gttgctgctg tttaccgcac ctactgcaat agtagaagga tattttgcag ggtagccgac 1006921 tgtgcttgtg cttccggatg aaccttcgtt tccggctgcg gcagcaacga cgataccgct 1006981 ggaaacggct ttgtcaacga ctgttttcag cgctgtagaa ccagtaggtc cgccaaggct 1007041 catgttgata acatccatat tgttggaaat ggcccactca atgccgttaa taatccagct 1007101 atattggccg cttcctgttg aatcaagcac ttttactgca tataatgatg cgcttggcgc 1007161 tacgcccaga acaccgattg agttattaag agcggcaatc gtaccggcta catgcgtacc 1007221 gtgagaactg ccgtcctggt atgggtttgt ttcagaaggt acgaagcttg ctccgcctct 1007281 gacgtttaag tcaggatgag aagagtcaat tccgctgtcg ataacagcta cttttacgtt 1007341 agagcctgtg tagccttgag agtgaagagc cggcgcttta atttgagaaa tgccataagg 1007401 aacagattgc gcatattcat gtgcaatatg atcttcttcc acatatgcaa cgctcggatc 1007461 ttttttcaat tcttttacag ctttttcatc caatgttgct gcggccgcgt taacatactt 1007521 aaattgcttt tgaacctttc cgcctttttc agaaataaca tcctttttct tggcggaact 1007581 catggcactc attgtctgtt taaatccgac aatgtatttc ttttctgtac tgctttttcc 1007641 ggcagcctgc gcagacatgt tgctgaacgc catcgtaaag attaacgtta acgcaaacaa 1007701 caagctgatc cacaattttt tgcttctcac tctttaccct ctccttttaa aaaaattcag 1007761 agtagactta cttaaaagac tattctgtga atttattgta atagatggaa taatatttta 1007821 gtagacccat ttttttgaga tgattttatc tctatttagg tatatcatct ctcgctattt 1007881 ccgtagagac tcgaaataac tattttcata cagaaaagaa cgaaaataga catgagtaaa 1007941 tgttcattat gctgaaatgt catgcttttt taggttaaat gctcctgagt cccggcaaat 1008001 tcctgtcgaa aaaattcgtt caaatgacct gcgtgtgctt ccgtgagaac aatggatatt 1008061 atcgtgatat tttttcaaag catgatgata aaagtattct gaaaaataaa ctttacagaa 1008121 aagggataga atgaaaaaat tattgagagg gaggaagaaa taagatgaac attcgccaag 1008181 caaagacatc agatgcggcc gccattgcgc cgctgtttaa ccaatatcgg gaattttata 1008241 gacaggcatc cgatttgcaa ggggcagagg cttttttgaa agctcgtttg gaaaatcacg 1008301 agtctgttat tttgatagca gaagaaaatg gagaattcat aggctttacc cagctctatc 1008361 caacgttttc ttctgtgtca atgaaaagga tatacatatt aaatgactta tttgtcgttc 1008421 ctcatgcgcg tacaaaggga gccggcggcc ggctgctttc tgccgcaaag gattatgcag 1008481 ggcaaaacgg ggcaaaatgt ttaacacttc agactgagca ccacaaccgg aaggcaagaa 1008541 gcttgtatga gcaaaacggc tatgaagagg ataccggatt tgtccattat tgtctcaatg 1008601 tgccggcgaa gtgaaaatgg cggcttgatg atttggtttt ttgaacgttc ttcggttacg 1008661 atataaatga aaaggagtgt gccgaatgtc aacgttattt caagccttgc aggcagaaaa 1008721 aaatgccgat gatgtttcag tccatgtgaa aaccatatca acagaggatt tgccgaagga 1008781 tggtgtcctg attaaagttg cttattccgg cattaattac aaagatggtc tggccggaaa 1008841 agcaggaggc aatatcgtca gagagtatcc gcttatttta ggcattgatg ctgcgggtac 1008901 ggtcgtctct tccaatgatc cgcgttttgc ggagggggat gaggtgatcg cgacaagcta 1008961 tgagctcggt gtctcacgtg atggcggatt aagtgaatac gcttcggtgc ctggtgactg 1009021 gctggtgcct ttgccacaga atctttcgtt aaaagaagcg atggtgtacg gaacggcggg 1009081 atttactgcg gcgttatcag tgcatcggct tgaacagaac ggtctgtctc cggaaaaagg 1009141 cagcgtgcta gtcacaggag caaccggcgg tgtcggcgga attgcggtat cgatgctgaa 1009201 caagcggggt tatgatgtgg tggcaagtac cggaaaccgg gaggcggctg attatttgaa 1009261 acagcttggt gcaagcgaag taatcagcag ggaagatgtc tatgacggaa cgcttaaggc 1009321 gctgtccaag cagcaatggc agggagcggt tgatccagtc ggcggaaaac agcttgcctc 1009381 gcttttaagc aaaattcaat acggcggatc tgtcgcagtg agcggcttaa ccggcggagg 1009441 agaagttccg gcaaccgtgt atccttttat tcttcgcgga gtaagcctgc tcggaatcga 1009501 ttcagtatat tgtccgatgg acgtcagagc cgctgtttgg gagcgcatgt cttctgatct 1009561 caagcctgat cagctgctga ccatcgtgga cagggaagta tcattggaag aaacgccggg 1009621 tgcgttaaaa gatattttgc aaaatcgcat tcaaggaaga gtgattgtga agctttaaca 1009681 ggatcagctt gcagagaatg ttatttttct gcaagctttt ttgtggacag gatgatcagc 1009741 tgctgaactg ctgtgtcgcg aaacaagatt ttcctgtaag ccgaactttc tcttctcatt 1009801 ttaaaaataa ttggtgataa tgattctcat tccgtgttat actactcttg gacatcttaa 1009861 ccatagaaac taccaacagg agagactgga acatatgaaa aaaacactga ttattcttac 1009921 agttttactt ctttctgtct taacggctgc ttgctcgtct tcaagcggca atcaaaacag 1009981 taaagaacat aaagtggcgg taacacatga tttagggaag acaaatgtgc ctgagcatcc 1010041 gaagcgggtt gttgttcttg agctaggttt tattgataca ctgcttgatc tcggcattac 1010101 gcctgtcggg gttgccgatg acaacaaagc gaagcagctg atcaacaagg atgtgctgaa 1010161 gaaaattgac ggctacacat ctgtcggcac tcgctcacag ccaagcatgg aaaaaatcgc 1010221 ttcattaaaa cccgatttaa ttattgctga cacgacccgg cataagaagg tgtacgatca 1010281 gctgaaaaaa atagcgccga cgattgcact taataattta aatgctgatt atcaggatac 1010341 aattgacgct tcgcttacga ttgcaaaagc agtcggcaag gagaaggaaa tggagaaaaa 1010401 gctgacggcg catgaagaaa agcttagcga gacaaagcag aaaatcagcg cgaacagcca 1010461 gtccgtgctt ttgatcggaa atacaaatga taccattatg gccagggatg aaaacttctt 1010521 tacatcgaga cttttaacac aggtcggcta ccgatatgca atcagtacgt caggcaatag 1010581 cgattcaagc aatggcggcg actctgtgaa tatgaaaatg acactggagc agctgctgaa 1010641 aacagatccg gatgtgatca tcctgatgac aggaaaaaca gatgacctcg acgccgacgg 1010701 taaacgcccg atcgaaaaga atgtcctttg gaaaaaactg aaggcagtga aaaacgggca 1010761 tgtataccac gtggatcgtg cggtgtggtc tctgcgccgc agtgtagacg gggcgaatgc 1010821 cattttggac gagcttcaaa aagagatgcc ggctgctaag aaataaaaga aaagacaggc 1010881 aaacgcctgt ctttttctta tttgataaag ccggataagt ggctgttgat attatagtct 1010941 tttatccgcc atttttcttc tgcaaattca atgttgctga ggcaggcgtt gacgagacgg 1011001 gtgctttgaa gctccgggtc accgccggat atttctgtca gcagggcgtg aattgccgca 1011061 ccgtgcgcca cgatcagcac cttcttgttt ggatacgcct gattcacttt tgccaaaccg 1011121 cccatcagcc tgtcagtgag ttcttctaag gtttccatat tcggatagat gttatctgga 1011181 tagcgctttg tccgttcctc cagcggcatg ccctccgcgt cgccgtaatc gcgttcctta 1011241 aaatcatcca tctcgactat cggaagatgc agatattcat taataatttc cgcggttctt 1011301 ttcgctcttt tcagcgggct cgtcacaata atatcccaag aaaagtcctt tacatattct 1011361 ccggtttctc ttgcttggcg ttcacctgtt gcgtttagcg ggatatcggt tttgccttgg 1011421 catttttgct gcaggttcca atcggtttct ccatgtctta ctaaacaaac ggctgtcata 1011481 aaatcccctt cctgacttta ttcatatcgc tattatacta aatcgaaagc gtgtgtccta 1011541 tgaaaaagcc tatgcaagaa cttcaaataa taaagccagt ccgattccgc cgccgcttcc 1011601 gatggctgca acagcatatt gacagtctgg ccgtcttttc gcttcataaa acaatctggt 1011661 taccagagct gcacctgatg caccgtacgg atggccaaga gctaaggcgc cgccgcgcac 1011721 attgattttt gaaaagggaa tgccgagttc ttgcgagcag acacaaattt tgacggcaaa 1011781 ggcttcattg atttcaaata aatcgatatc atcaggtgtt acatcgtgtg tatgtaagag 1011841 ctgacgaatc gcgacaaccg gtgccgcggg cggaaagttg gggtgaatgc cgctgacagc 1011901 gctgccgata aaccgaagca caggcttaag tcccagggct gctgcttttt cttcttccat 1011961 taccaaaaga gcggctgctc cgtctgctat gccactgctg ttggctgctg tgactgttcc 1012021 ggagctggtg tcgaaaaccg gctttgcacg gggaataatc gcttctattg gccgcgtttt 1012081 caaaaatgct tcgtccgtct ccaattcccc gagagcaaca acttcttcac ggtaaaatcc 1012141 ttcatcatgc gcgttcctgc tgcgttgatg gctgagaagc gcgtactcat cctgcatgct 1012201 tctgctgatg gaatagcgtg cagccgtata ttctgccgca atgcccatgt ctggatcgcc 1012261 gatcgcatct ggagaaaagc gagcccgttc tgaaaaaggg gattggctgc tgctttctga 1012321 gccgcccgcg atatacatcg tgccggctcc cgcttgaata aggctgcagg catagcgcac 1012381 agcttcaagg ccggagccgc actgtctgtc aattgtcatt ccgggaaccg ataaaggcag 1012441 tccggcttga agggctgaca gtctggccag gttgccgcct ctgccagtag cgtttccgag 1012501 aatgacctcg tcaacttgat cctctagctt tcggctgaga cagcggatga tgggagccgc 1012561 caaatcctcc ggcaggaagg gcttcagcag tccgttttga tttccaaaga tcgttcgttt 1012621 tgcatcaaca ataaccgcat tcatttatac tgtacactct cttccagcca ttttttcact 1012681 ctggaacggg caatttttcc gctgctcgtt tccggcaagc tgtctgcaaa cacccatttt 1012741 ttcggaattt tataggaggc taatttctgt ttacaccagg ctttcagtgt tctggcatta 1012801 gcgtttccaa gaatgacagc tacagcgatt tctccccaat actcgtcggg aatgccaacg 1012861 acagccgcgc tttcaacctc tgggcaggcg agaagcacac gttcaatttc ttctgggaaa 1012921 atatttaatc ctccgtacac gatcatcccg ttttctcttc ctgatatgta tagaaagccc 1012981 tcttcatcaa cgtagcccat atcatctact gtcatccatt catctggtgt gctgccgttc 1013041 acatagccgg aaaacctcat cgggcttttg acaaatattt ttccgatttc tcctggctgg 1013101 cagcgttctc ctccagcgtt gcggatttcg atccggacat tatgaaaagg gcggcccgct 1013161 gaatgcggct tccgtttgct gtcttccggt gaagaaaacg tcacaaaact aagctctgat 1013221 gtgccgtaaa aatcgtacag cttgagatga ggccatgcag cggcaagctt cttcttggat 1013281 tctgccggcc agtctgcgcc ggatgaaatg attttgacgg gactgtcggg aaaaccctca 1013341 atccttgcga gggcgtctgt catcgtcggt acggtataga gaacactgat ggattcacgg 1013401 cacagccatt ccttcgcttt ggcaggagaa aactttttca gcaaacaaac ggttcctccg 1013461 agaaacaaag tgctgacagc cccatatagg aagtgagagg acattaacgc tccgggaatc 1013521 agaaccttat catctgatga aatcgaaaaa tctgtttctg tacaggtaaa gctctccatc 1013581 catgagcggt gagatcgcgt aaaggccttc ggttttcctg tcgagcccga cgtaaatccc 1013641 atataaaaag ggtgctccgg atcaatggta ggcaagggat cagcggctgc ctcagaaata 1013701 tctgccatac agttatccag caatacaaca ggtgtctggc tatctgtcag tttgtttttg 1013761 aaaaaggcta aagtaaccac aagatccgca ttgcttatgg acagccgctc cttacattca 1013821 gccgggctcc agcgtgtgtc gatgggaatg gccgtacatc cagccgctgc ggctccggca 1013881 aacagctgta aaaacgcgag actatttggg agcaggatcg ccacacgatt cggcatgctc 1013941 ggctgtgacc gcagccaatt tgcggtttga gagacaagcc gatcccaatc atggtacgtg 1014001 atttgctccg attcagtctg gatcgctaca cggccgggcg atgtttcggc agtagatgaa 1014061 taggtatgag taattgtcat gtattgtcat cctccttttg taaacatcgt atcagaaaga 1014121 gacaaggctt gagtgatttt tatcgccaga aatgcagata cagccgcttt tatcaaatca 1014181 ccaggcacat atgcaaggct catgaaggcg gcctgtgaca aatcaatatg catgataaaa 1014241 gcttgtaccg gtataccaag cagataaata aagatgatgc cgaatacgat atgagtgaaa 1014301 aagagacgca atactgtcac cttccgcagc ctgttagcgg ctaaactgat cagccatgaa 1014361 gcgaggggat aagcaatcaa aaagcctgcg ctcggtccga aaaacacacc aaaaccgcct 1014421 cgtccgccgg gcaacagcgg cgctccgaag gcgacgagca gcaaaaagac aagctggctt 1014481 aagaaagcag actttggcct gagaatgctg cctgccaaca tgacaccaag cgtttgcaat 1014541 gtaatcggaa cgggtgtaaa ggataagaag agagggggca taaagccgag cactgccatc 1014601 agcgcggtga aaatcgcaat atgcatcatg tcgattaatt tcagcatgtg aaatcctcca 1014661 aaaagtaatc aaatatggtt atacaataaa tgcaggtaat tattatgtca actgattttt 1014721 aatttaagtt tacataatga acgcaaaaaa accggccgta tggcagaccg gtttttgatg 1014781 gttattcttc tgtcaggatg acaagcgaat caacggaagc ggccacatgg gaaacggcgc 1014841 ggctgacttc ctgaagccct ccaagaaagg cttgcagatc gacgtcgatt ttgcctgatt 1014901 gctctttgct gattttcatg ctgtggacga tttcatcgaa taagcggtta atttgcgtca 1014961 ttttttcttt actttcgctg actagctcat tcacgtcttt gatatgcttg gatacaatgt 1015021 tgatttgtgt attcgtattg ttcacaagct cagaaacagt agagacggtt tttttcgtat 1015081 cctcagaaag cttccgcact tcatttgcca cgacagcaaa gcctttgccg tgttctccgg 1015141 cgcgggcgga ttcaatagat gcattgagcg agagaaggtt tgtttgttca gctatgcctg 1015201 tgacgatgcc gaagattttt tcaatttgct gcgcgatttc atccagcttg accatttctt 1015261 tttcgatttg gacaaggctt gtgtcaattt tgttcatctg tttttgctgg acttctagct 1015321 ctttttttcc gccgatcgac ttttcttcaa cagtgctgga tgttacagtg ccggctttgg 1015381 atgcttgaga aatgccttca gatttgtcca caagctcttg aactgatctg cttgtttctg 1015441 aaaacagatt ggcaatcgat ccagaggttt cttgaatttt ctgatgaaga aggtttttct 1015501 tttcttcttg ttcatcacgg gtctggttgt actcgctttg aaacgcttca aggacaagct 1015561 gctgttctaa gttcaagatt tttgttgttg ctttaatggc ttttagcagt tcttgctgat 1015621 ttgtaatgga cgcttcataa atgtcaatca ttgacaaaag gagctcttga aacgcaccca 1015681 tataccattt tggcaaaagg ccgattctta aatggatgga ggcgattcgg ttacgctttt 1015741 caataaattc atcatcgata acgcctgcaa acatttcctg aatatgccgt tttaacgttt 1015801 gttttaagcg gtcaactgag ctgtgatcat taatgatatc catcaatgag ctttcatggt 1015861 caaggttttt ataaaacgca tcgacgatat ttacgatatt ttcttgaatg agtggctgaa 1015921 gctgctctaa cacataaagc tcagcatctc ccaacctgac cattttgagc tgttttttga 1015981 catctgcatg tttgtttgtg agctgaatgc ggtttttttg ttgtccgttt gaatctgaaa 1016041 agtaagctgt ttcttgtttt ctgtcttttt taaataacaa tacaatgatc ccccttggga 1016101 aaaatataat ttttactttt tggcttttta agcctttttc ttttttatcg gccaagggaa 1016161 acatgaatga agctgcagat gaaaaatatt tgaaaaaacg ttcattaaaa tgaacggttt 1016221 aatcgagatc tatttgtttt aatggtttaa tggccggacc ctctacaact tcgccagatg 1016281 gcttaaagcg tgatccgtgg cacggacaat cccacgtatg ctcactgtcg ttccactcga 1016341 cctcgcagcc taaatgggta caagtcgtat caacgagatg gaggcagcct gtctcatcac 1016401 gaaatgctcc cgctcgcctg ccgtttatgg tgacggcttt cccttctcct ggcgaaatgt 1016461 cttcaaattg gacatcaggc ttttcaagct ttccttttat caaatgcttg gcgacatctg 1016521 cattgtagga aatcactttc tgcaacccgg gattcagatg gaaacgggac ggcgtgaaaa 1016581 tgctttcgta tgggttttct tttttctcca caaggtctga caataaagtg gctgcgactg 1016641 ctgaggacgt catgccccat tttttgaacc cggtcgctac tagaatattg tcctcatttt 1016701 ccgacatcgg cccgataaac gggattttgt cgatcgtcac tagatcttgg gtggaccaat 1016761 aatatggaat gctttcgatg ccgatggtgc tttcggccag ttgtctcagt gtttcataat 1016821 gtgtagacat ggcttttccc tggcctgttt tatggcttac tccgctgaag agaatcagct 1016881 tttcaccgtt tacaaccgta tagcggagcg ccactgacgg ctgatcgata ctcaaataca 1016941 tgccctcggg atactcgatc ttcggcttga tggcaaggac ataagatctg tcggagtaca 1017001 ttctcgcagc atataatccg cctccgtcat aaaaagggaa gtgggaacag catatgataa 1017061 agcggctctt aatggcgtgc cggctttttg ttaccacttc gggcctttcg ccttttttga 1017121 tatcaagcgc aacggtctct tcataaattc ggccgccttt ttgaacaatt tgctccagaa 1017181 gcgcttttaa gtattgaagc ggatgaaatt gagcttgatt cttcatgaca agcgccagct 1017241 tagaacctaa gggaattgga agatccttga taaggtctct ttcaattccg agctttgtgt 1017301 atgcctcatg ctcggtgtgg attttttgaa cagcgttttc atttgccgta taaagatatg 1017361 cgtcttgctc gatccattca caatcaattt gatgttcatc cacaatgcct tttatgtaat 1017421 caattgcgtt ttggtttgct tcataataaa gcctcgcatg gtttaatccg aaatggcgga 1017481 taaattcgtc gtatatcatg tcatgctgtg cggtaacttt agcagttgta tgcgcagtgg 1017541 ttccgttaag aacctgattt gcttcaatca aaacgacacg gaagcctctc ttcgtaagtt 1017601 catatgccgt tgtgattccc gtaatcccgc ctccgataat ggtgacgtca cattcagtgt 1017661 cctcttgaag cgcaggaaaa gaaggcaggt cagttgatgt tttccagtat gtttcaggtg 1017721 cttcctttgc aaaatgttga ttagccaagc cgttatacct ccaatcagat ttattcttaa 1017781 tttttccata ttctatcttt tcatacatag gaagcaggca ttgttcataa cataataagg 1017841 ttgaaaagga gtgatttcat tggcgaatca aaaaaagaaa acattaccgc ctcagcacca 1017901 gaaccagcag cctggttttg aatatctgat ggacccgcgt ccggtttttg ataagccgaa 1017961 gaaagcgaaa aaattagagg gcaaaaccgc tattattact ggaggagaca gcgggattgg 1018021 acgcgctgtc tcggtgttat tcgcaaaaga aggggctaat gtggtcattg tgtatttgaa 1018081 tgaacatcag gacgccgagg aaacaaagca gtatgtagaa aaggaagggg taaaatgcct 1018141 gctgattgca ggagatgtcg gggatgaagc gttttgcaat gatgtggtcg ggcaggcaag 1018201 ccaagtgttt ccatccattg atatattggt taacaatgca gctgagcagc atgtccagcc 1018261 cagcattgaa aaaatcacca gccaccagct gatcagaacc ttccaaacaa acattttttc 1018321 catgttttac ttaacaaagg cagtgctgcc tcatttaaaa aaagggagct ctattattaa 1018381 taccgcttca attaccgcct ataaaggcaa taaaacgctg atcgattatt cagcgacaaa 1018441 aggcgcgatc gttacgttta caaggtccct ttcccagtcg cttgttcagc agggcatacg 1018501 ggtcaatgca gtggcaccgg gtcccatttg gacaccgctt atcccggcca gctttgccgc 1018561 aaaagacgtg gaagtgtttg gttcagacgt gccgatggaa cgcccggggc agccggtcga 1018621 agtggcgcca agctatctat accttgccag cgacgattcc acatacgtca cagggcagac 1018681 gattcacgtc aatggcggaa caattgtgaa cggataataa aaagccaatc cttgaaggat 1018741 tggcttattc gctctgcttg agcgctgcat attctttaga gagcgtaaga aacgcatctt 1018801 tatctttttc gtccaaggct ttgttaattt ggtccgtcag catggcaagc cgacggttat 1018861 acaaggattc atcgagcacc atttgaatgt aaatatccgt cattgtgaca tcgaattctt 1018921 ttgttttttg cgtgttgcgg gacttcatga gctcagtgta cgattttttc tctttcataa 1018981 agaatccccc caatgccttt tttatagtat atggataacg gtcgaaaaaa tcaataaatt 1019041 tttataattt ttagacaact aatacttggc aatctatcga catatcctgc aaaatgccgt 1019101 aaaccggcaa gtcttatgaa agtaaaatcg gtttattact agtcatttag taccattaaa 1019161 tatcattaaa agatgatttt atcttaaatg ttaaaaaaac ctgtcgtttt acaaaaacag 1019221 atgatagatt attagtataa attttgcaga aaaaggatgg aggccataat atgagtcaga 1019281 aaacagacgc acctttagaa tcgtatgaag tgaacggcgc aacaattgcc gtgctgccag 1019341 aagaaataga cggcaaaatc tgttccaaaa ttattgaaaa agattgcgtg ttttatgtaa 1019401 acatgaagcc gctgcaaatt gtcgacagaa gctgccgatt ttttggatca agctatgcgg 1019461 gaagaaaagc aggaacttat gaagtgacaa aaatttcaca caagccgccg atcatggtgg 1019521 acccttcgaa ccaaatcttt ttattcccta cactttcttc gacaagaccc caatgcggct 1019581 ggatttccca tgtgcatgta aaagaattca aagcgactga attcgacgat acggaagtga 1019641 cgttttccaa tgggaaaacg atggagctgc cgatctctta taattcgttc gagaaccagg 1019701 tataccgaac agcgtggctc agaaccaaat tccaagacag aatcgaccac cgcgtgccga 1019761 aaagacagga atttatgctg tacccgaaag aagagcggac gaagatgatt tatgatttta 1019821 ttttgcgtga gctcggggaa cggtattaga aaaataggaa ggagctgacc gaacagggca 1019881 gctcctttca taaagctatg ccgtcggaat tcctccggtg atgccatata cctgagatgt 1019941 cacatagctt gaattctctg aagctagaaa tacataaaca tcggccaatt ccactggctg 1020001 cccagcgcga tttaatggag ctggcggcgt gccttgtccg aatttcggga tgttttccgt 1020061 cggctgtccg ccggaaattt gcagcggtgt ccaaattggt ccgggcgcaa ctgaatttac 1020121 tctgatgcct ttggaagcaa gctgttttcc cagtccgacg gtaaagccga taatggcgtt 1020181 tttcgttgct gcgtaatcta acagcatcgg gcttggatta tagccttcaa ctgaggtagt 1020241 tgtgataatt gaagctccct ccggcaaata cggaagcgcc gcttttacaa cccagtaaag 1020301 ggaaaagacg ttcacttcaa atgttttata gatttgttca gtaggcagat cttcgatgtt 1020361 ttcgaccgct tgctgtttgc ctgcaacgag cgctagcaca tcaagtccgc cgagttcgtg 1020421 atgcgactgt ttgactagat cttggcaaaa ggattcgtcg ctcaagtctc cggggatcag 1020481 cactgctttt cggccttctg cttcaatcag ctcttttacc tcttcagcat ctggctgttc 1020541 ctcgggcaag tagttaatag ccacatcggc accttctctg gcgtaagcaa ttgcggcagc 1020601 gcggccgata ccggaatcgc cgcccgtgac aagcgctttt cgacccgtta gtttacctga 1020661 tcctttgtag cttttttctc cgcaatcagg gacaggcttc atgttctttt gcaggcctgg 1020721 cggttcttga tattgttcgg gaaattcatc atgaaaaaat gcttttatag gattcgtaag 1020781 atttgaatca gacatcagca acgctccttt tctgtttggt gtacattcgt atgtgtaccc 1020841 ctgagcataa gcagaaaaac atgttttggc agtttgaata gtgaaggaaa aagaaaacaa 1020901 gaaaaaacaa agccttcttc catatttatc ttgtcaaata agactatatg aattatgata 1020961 aattcgagct ataaatcaac taaatattgg gtgttgggag agtgaatcgt catgaaaaaa 1021021 gcggcggcgg ttttgctgtc actcggtctc gttttcggtt tttcatacgg agctggccat 1021081 gtggcggaag ccaaaacaaa ggtgaaggtc tataagaact gcaaggagct aaacaaagta 1021141 tacaaaggcg gagtggcccg cacatcgaag gtgaaaaaca aaggcggaaa aacgaagtac 1021201 aagccttacg tttctaaggc actttacgat gccaataaaa acaaagaccg cgataaagat 1021261 cttatcgcct gtgaacggta aataagaaaa agcaatctgg tgtccagatt gcttttttta 1021321 tgcttaggcc gcctgatcgg ccgcagcgct tttcgccttc cttgtcataa ggctgactgc 1021381 catcatgacc gtgatattca aaagcagggc gacgatgccg acattcaagt cttttgcggc 1021441 ttgcggcaga gccggaaata aagtgccgat cgtcgtttcc gtcattgtaa tataagtaac 1021501 tgctccgaca cctgcaataa tgccggcgaa agctccttgc tttgtcacca tattatgctt 1021561 gagcaggctg aacaaaaggg cggggaatag ctgtgtgaca aggctgtagc ccatcaaaag 1021621 cagcgtaacg atggtattcc cgcctttgaa ggtaaaatac accgaaatca gcgcaatcac 1021681 cggcactaaa aacttagcaa gcgccgatac ttgctgttct gtcgtgcggg gcgcgattac 1021741 cttgtacaca ttttttgcaa acagtgtgga ggcggacatt aagatcatag accctggcac 1021801 aagtgctgtc agcagtccgg cagcaccgat aattccgaca aaccaagggt caaatgcttg 1021861 cagagacagt ctcaaaagcg acaaatcccc gtctgcgcca ttcagatctg gaacttgcag 1021921 gatagccgca aagccgacga aaaggacgaa gagcaggacc agctggtaca aaggcatgat 1021981 gatggcgttt ttacgaaaca cttttgggtt ttcggctgaa tacgaagcgg aaaacgtgtg 1022041 aggccacatg taaaaaccaa gcgctgtcaa gagtacggtt gaactgaacc aggccacact 1022101 ttgtcccgat tcggggagcg taagaaagcc aggctttgcc gtttcaatct gctgaaacat 1022161 gtcttgaaat ccgccgtagt aatgaattgg caaatacaca cctaaaaaca gaacgacaac 1022221 cagaatcatg atgtccttca caaccgatat ccaggcagac ccgtgaatgc ctgaaaccat 1022281 aacataaacc gtgatggaaa cagcgccgat ccagatggca gcggtcgggg tgattttgcc 1022341 gtacgaggtt tccgatacaa tcagcccgag gcctttcagc tgcagtacaa gatagggaat 1022401 gagtgcggcg atgccgacca gtgaaacgag aatgccaagc agcggactgt tgtatttttt 1022461 tgtgaaaaaa tcagactgcg acatcagttt atgctgtttc gcgtacgtcc aaactgctgg 1022521 aagaagccag taagaaagga tgtaggccag acatccgtag gcgatgatat aaaaggctgg 1022581 accgcctttt ccgtaggccc agccgctgcc gccgagaaac gtaaaagtag tataaatttc 1022641 gcctgccatc aaaaggaaga cgaaaacagt tccgaagccg cgccctccga ccgtccactg 1022701 ctccaggttc atgtcttttc ctttttgggc gcgtataccg agaaaaatac tcaagagcag 1022761 gacaccgaag atgatgatga gagctgcatt cattctgctt cctccttttt attttccttg 1022821 tcgaggacat acacaatcgc catcagcgca gaggtcaaaa gagcccacat cacaatatag 1022881 gcaagaataa acggcatgcc gaacacatag ggggtcacct tatttgcaaa agggatgccg 1022941 agtaagattc cgataaaggg taaagcggca agaacgtgaa tcagtttcat agaatcctcc 1023001 ttctatttag gattgaggtg tacaagccta agcgtactga aaatgatgtc gcagatatcg 1023061 cagcacatgt cattttttgg agtgaaaggc tgtggttcga attataaata aatttatttt 1023121 gtttgtatag tgtgaattgt ctgaaattaa tgctctgaat cgcccgaaga gggaacgggc 1023181 agtatgattc aaaaggctca gagtctgtct ggggcaaata gatagtatgt taataattcg 1023241 ctgacctgct cacggattcg cggattaaaa tagcgatggt tttcttcata accgtcgatg 1023301 acaaatgtat agagtgtaaa ggcctcatcg cgttccgtct cgcggattgc aatttttctt 1023361 ttcctcagtt cttttctgac ctccatcaaa tccttttgtg ctatttttaa tgattcgctg 1023421 ataagctgtt tataaggatg cttcaatttt aatgtgcttt cttcaattcc ggcgagatca 1023481 cggttaaaaa tcgtaatggc catgggcaaa aagagagccc gttcaattaa atcgtatatt 1023541 tcctcctgca gatttggcat attgactcct tctttctaag ggaacgtttg ttctatttgt 1023601 attctatatc ggctggtgaa atgtttcaag acagaaaaaa tcaccaaaac tttttagttt 1023661 tctgctgata atgtgtagaa taaggataga caaacccggt aaggagtata aatgttggag 1023721 cattttttat cctatttgac acaagaacat ttaactgaat tatttcaaag ctatagggct 1023781 ttcggtccgc tcattgctgt gctgctgcct ttaattgaag catttctccc gtttttgccg 1023841 ctgatcgtgt ttgtggtggc gaatacgaac tcgtttggct tgtgggaagg attcatccta 1023901 tcctgggcgg gatcaactgc tggttccatt ctcgtctttt tgattgtccg tcaatacgga 1023961 cagagaaaat tgcttggatt tatccgcagt catccgtctg tcagaaagct gatgttatgg 1024021 gtggaaagac acggcttcgg tcccatgttt cttctgcttt gttttccatt tacaccgtca 1024081 gccgcggtga atgttgttgc cggtttgtca aggatcggaa cgcggccgtt tattttggcg 1024141 gcagcctcgg ggaagcttgt catgattttt atgatcagct tcatcggata tgatctgcac 1024201 gcgctgatta cacagccgat tcgaacggtc atcgccgtat tggtgatcac tgtcttatgg 1024261 tatgtcggca aaaaggtgga gcggtatctg catgtaagag ccagtcagcg tgagcatgat 1024321 ggagggagac agtaacatga aaaaacggtt ttggtttctt gccggtgtag tgtccgttgt 1024381 tctcgccatt caggttaaaa atgctgtctt tattgattac aaggtagaag gcgtcagtat 1024441 gaacccgacc ttccaggaag gaaacgaatt gttggtcaat aaattttcgc atcgatttaa 1024501 aaccatccat cgttttgaca tcgtcctttt taaaggccct gatcataaag tgctgattaa 1024561 acgggtaatc ggcttgcccg gtgaaacgat caaatataaa gatgatcagc tgtatgtgaa 1024621 cggaaagcag gttgctgagc catttttgaa gcatttgaaa tctgtttctg ccggcagcca 1024681 tgtaacgggt gatttttctt tgaaagatgt gacgggaaca agcaaggtgc cgaaaggaaa 1024741 atattttgtc gttggagata atcgcatata cagcttcgac agccggcatt ttggtccgat 1024801 aagagaaaaa aatattgtcg gtgtgatttc tgatgccgaa taaaaagacg ctaattgaag 1024861 aggcgtcttt ttgtatgccg tttggaaaaa tgtgttgaag aaaaatttgt aaggagctat 1024921 aatcaaaatt gttacctgtg taacaaaatt tatatatttt tttgactgga gggccgtttt 1024981 tattggtttt tgttcgtttt tcatgaaaca aaaggagtgg tgaatgatga tgaaatatga 1025041 agcagtgatt ataggaggag ggccggttgg atttatgctg gcttctgagc ttgcaatagc 1025101 cggagtggga acatgtgtga ttgaacggct tgaaaaacct gttccgcatt ccaaggcgtt 1025161 gacgctgcac ccccgaacgc tggagcttct tgagatgaga gggattttag agcggttcgt 1025221 atccaaggga agcaagatac ctaccggaca tttttcaatg ctggataccc gtctggattt 1025281 ttcaggcttg gatacgagct gtccttacac gcttttgctc ccgcagtcca aaacagaaaa 1025341 gcttcttgaa gatcatgcac gaagcctggg aacagaggtg tttcggggtg ccgaggcgct 1025401 ggcggttacg caaaacgggg aagcggtcca aacaattttt aaggatcggg acggcagtgt 1025461 acggacgatc acaagcaagt ttgccgttgg ggcagatggc gccgggagta ccgtccggaa 1025521 acaggcgaaa attgagtttc cgggaacaga cagcactgtc accgctgcgc ttggggatgt 1025581 ggtgctcctt tctccgccgc cgtcaggtgt gctgtccctt tgcacaaaag agggcggtgt 1025641 tatgattgtt ccgttatctc cagaccgata ccgtgtcgtt gtgatcagcc cttatcgcac 1025701 acaaacgccg aaagatgtgc ctgtgactga ggaagagctg aaagctgacc tcctgcgaat 1025761 ttgcggaact gacttcggtt taaccgaccc ttcgtggatg tcgcggtttg ggaacgccgc 1025821 gcgccaagcg aaacggtatc gggacggcag aatctttctt gcgggtgatg ccgcgcatat 1025881 tcattttccg gcgggcgggc aaggactgaa tgtcggcctt caggatgcaa tgaacctcgg 1025941 gtggaaactg gcggcggcca tcaaaggctc tgcgccttct tggcttttgg acagctacca 1026001 tgatgagcgg catccggcag cggaagggct cctcagaaac acggaggcac agacaaagct 1026061 gatcgatttc actcaagcag gcctccattt gcgaagcatg atgtcggagc tgctggcctt 1026121 ccctgatgtg aatcgatatg tagcggggca aatttctgcg ctcgatgtca gatatgaagc 1026181 tgatcgtacc atgccgccga atcgtttgaa cggggcaagg ctccctgaca tgaagctgat 1026241 tctttccgac ggcaattcgg aacggctgta cagctttctc caaaacggga cattcgtttt 1026301 gctgtcattg aggcaggaag ctgatgatca tatcgaagta aaaggcttac gtacggtaac 1026361 cgcctcgctt gcagaaccga atgaaaagtt gcggaatgtg cataccatat tgattcgtcc 1026421 cgatggacat gtagcctggg cggtggatgc atcagcgccc gattgttccg aggtgattca 1026481 aaaagggatc agccgctggt tttccgtcac cagccgagta taattcaatt cgattgtttc 1026541 atctgtaaca aaacggtatg atagaagaaa caatcgaatg aaaaaggatg gaaaacccga 1026601 tgaacacaga tcatacgaaa cgcaatcttt ttgaattgta tgcggagctc attcatcagc 1026661 aggagaaatg ggaggggctt attaaagcct ttttatctga cgaattgagg aagctggatg 1026721 tagagcacgg gagtaaatct caattgacga tgacagaaat tcatgttcta tcctgtgtcg 1026781 gggacaatga accaattaat gtcacgtcga tagcagaaaa aatgaatacg acaaaagcga 1026841 ctgtatcacg catcagcaca aaattgctcg gcgcaggctt ccttcacaga acacagctca 1026901 gcgataataa aaaggaggtc tacttccgat tgacgcctgc tggaaaaaag ctgcacagtt 1026961 tgcacaaata ttatcatcag aaggctgaac agcgttttct gtcatttttt gaccgctata 1027021 ccgaggaaga gattcttttt gcggaacggc tgtttcggga tctggtgaca aaatggtatc 1027081 cgtcgtcaga agaaattgaa ggggggcttc ctagcatttt taaataaaaa acacgcactg 1027141 cggtgcgtgt ttttcgcttt gcggccgcct cgagaattct ttcatttcac cctctggcag 1027201 cactcacttc aaatctgatc cattaacaac gaaatatccg cttatatttc ctcatctcga 1027261 tggtttgcga attaaaagtt cttgaaccct tttttcaact aggcactact gccgctgatt 1027321 gagctctttt tgtctttttt ttcaccatga agatggtgaa gcaggcgata aaacggcggc 1027381 agcagggcaa taaccagaat gacgcgaatg acctgaaccg caacgacaaa ggtggaatca 1027441 gcatgtaagg taactgacgt cgtcgccatc tctgcaatcc cgccgggcgc aaatgccaga 1027501 acagaagtga tgagcgaaat tcctgtcagc tcggaaacga tcacggcgct caaaaacatt 1027561 gctgcgatta aaccgacgga cgagacaaac ccgacgatga taatacgggt gacgccggca 1027621 aacatgcttt tgtacatctt agagccgatc gttgccccga gaaatacttg tgatacatgg 1027681 ttagcttgtg acaaccacca tgccgtcatg tcgtgccctg tcaccgcagc tccgccaaca 1027741 tgtacaattg ctacaccgag catgctgccg agcagccatg gagctggaaa ttttaaaaat 1027801 ttcgcagctt tgcaagctcc ccaggcagcg agaataagaa tgacggtcca caaaacggga 1027861 gcgagcctaa aatctgtcgt tgcagaagaa atcgtctctg ctgcggcact tgcggtacga 1027921 tcttgttttg tatagatcag aatgactaaa aacggaatgg aaagcaccac gagcagcaca 1027981 cgcatcattt gaacgaggct gactatagcg gtattggcgc ctacttcctg tgcgatgctc 1028041 ggcatggcgg aaagtccgcc gggagcggtg ccgacaaagc tagtcatcat atccgttttg 1028101 ctgaaacgcc aaagcacata tcctgacagc atggccagca ggatagacaa tatcagcata 1028161 acgccgactg aaaaccaatg gtctttgaga acagagagaa cggataaatt cagcttttgg 1028221 cccaattcga tgccgaggat catctgcccg agggcgagcc atcgtcggtt aattcctttt 1028281 tggtctggtg ccatcatcag ccatgccggc cgtatcatgg cgaggcagca ggcgacaatc 1028341 agtgttccga tcatccatcc aattgatatt ccggttaatg aaagaataaa ccccccggct 1028401 gcactgattg cgataaacca tagatctttg aggagatttt cgtctttctt caatgtaaaa 1028461 cccttcttcc tttttcacgt aacactccaa ttgttcacgt agtgaatgta tttattacta 1028521 tagtatattt ttgttgataa agaaattatg aattattttc tataagcgat tcacttttct 1028581 tatgaccttg tgttcgagct tttctattgt gtaagtcaga gataaacccg ctgtcagcag 1028641 acacacggca agagcgtaaa aaatcacttc tccgccaaat gatgtcagga tcagcccgcc 1028701 tgccagcggt ccgattgagc gggatatatc ccaatgcaga ccatagacag cataaaaccg 1028761 gcccagcaaa tgaggcggcg ccaatttcga tatgaaggtc tggatgtggg ttagcccgat 1028821 gctttcacca accgtcatca ccgctgccgt cactaaaagc attgtcagag aggttgagca 1028881 tgcaaagccg gctgccgcaa gggagtagca aatataagta atgaagagga tcgttttcat 1028941 tgaaagcttt tcggtccctt tgacaagagg tacttggaga acacagctga ataaagcttt 1029001 tgctgctgaa tagatggtca gcatggacag ataatcagaa aacatgtttt tgctgaacag 1029061 cctgtatgtt gtttctgttt gtgcatataa catgctgatg gggagagaaa gcagcaaaag 1029121 aagcaggaca ggcctgtata ttgtaaagct cgcggacatt ttcggggtaa cagctgggtg 1029181 tagcggcttt gtctcaggca gtttcagtgc agcgatcaga aagtagataa acaatgctgc 1029241 agcatctaat gcgaatatcc acacggggtt atgattgtac agcagcatcc ccactagcgg 1029301 tcctgccgtc agacccgtcg aatagatcgc attgatgacc gcaaacactt ccgaacgtct 1029361 gctttccggc gtgctttcag cgatttgggc gcgggaagcg ggaatgtaca acgatcttcc 1029421 gatgccattc atgacataga gaatagcgaa aacatacgca tgctcagcaa atacaaaccc 1029481 tgtcattgcc gctgattgaa gaagcaatgc ggtcaaaatc gctgtgcgcc gcccaagccg 1029541 atccgtcacc cgtcctgcag cgagcgtcag gaaaatatca gcaaatggct gaaggctgat 1029601 gatcagcatt ggcatcatga tactgccgtt taattgttca tgcagataca gcaccataaa 1029661 aggtcccatc attgcacctg tcaggcttgt cagcaattcg ccgaaaaagc ggagccgaac 1029721 gggagcggta tatctcgatt ttatagagtg aaaactggtc aacatgtgat cgccgccttt 1029781 cgctgtttga tatagtagta gtgtatagaa ggggcggcgg cccaaaaagt gaagaaaaga 1029841 agagataaaa gttccccttt tgtcgggagg tgcggggatt gaagctgata gagcactacg 1029901 tggcgcttgt aaaaacaggc tgcgccgagt atgggcaaat gaacgaaatg acgctcactg 1029961 agattgccga ctgtttattt tgtacagaaa gaaatgcaaa gctcatttta cataagctgg 1030021 agaacagcaa ttggattatc cgggaaagcg gggcggggcg cggccgcaaa tctaaaatcg 1030081 cgtttcttcg gaggcctgag gaactgcttc ttcaaactgc aaaggaatat accatgtcag 1030141 gaaagcttaa aaaggcaaag gagctgcttc agcagtatca gtccgcgttt ccagggcttc 1030201 aaaacgaata taacatgtgg ctatcagagg tattcggatt tgtgacggag acaggcgaga 1030261 atggggcgaa ggatgtcctg cggctgttca tcacgcctga atctgtcagc agtttggatc 1030321 catgccaaat atttttgcgg tctgagggcc atttcgtcaa acagatattt gatacactct 1030381 tcacgtttga ttcggatatg caggagccga agcctcattt ggttcatgga tgggaagagg 1030441 tcggaaaaaa acaatggaga ttttttcttc gaaaaggtgt gttatttcat aatggacagc 1030501 cgctgacatc gcgggacgtt gcgtttacat ttcagcgctt tttggaactg gctgacaacc 1030561 cgtataaatg gcttctgcac ggagtgaaac aagtcttaga aaagggccct tattgtgtgg 1030621 agctcatact cgataagccg aatgcgcttt tgccgtatgc tctttgtgat gaacggctgt 1030681 ccatactgcc ggcagaacag ggcggcggga aaaatggaac agggcctttt cagatgaatc 1030741 agcaacatag cgggatgctt gtgcttgaag ccaatgagcg ctacttcaag ggacgcccct 1030801 atttggatcg cgttgagttt gtgttttctg agcaagccgg agagatgaac ggttttacca 1030861 ttcaagaaaa acaaacatgt cctgagcagc aaactgtctt tgatgagcgg catgttcagt 1030921 atttgtcgct taatctgaaa aagaaggggc ctcttcagca ccgaagcttt agaaaagcgc 1030981 tccggctgct gatttcctct gaacggctcg ttcgtgaagc gggagggcac cgaagaattc 1031041 cggttacgtc ctttttgcat ccgagtcctt ttgagtggga gggcgtttcg ccatctgaat 1031101 tgttgaaaaa aagcggatac gagggcgaaa caatcgtgct ttataccttt tcggaaacgg 1031161 atcatcgtga ggacgccgaa tggattcaaa atatttgcgc ccagcacggt atcaggctta 1031221 cacttcaatt ctgtgatgct gctgatctgc gacggccgga aatcgtgcag atggcggata 1031281 tcattcatga cagtgcgacg ttttatcaag acagcgagtt tggttttctg catttgctgc 1031341 tgtcggagaa cagtttcttg tatcagcatc tatctgaaaa gctgacacag atttgctcag 1031401 gaatgacaga gcggatgttt tccatgcctg accgctgttc gagaatcaac atcctgcgtg 1031461 acattgaccg gcagatgata caggagctga acgcgatccc gctgtatcaa aatgtgctcc 1031521 aggtgacatc aagtaaaaat gtaaaaggcc tggtgcttga tgaagaggga tggattgatt 1031581 tgtactccgt atggctgtcc aaataaaaag agggttcttt tttgaaccct cttttttacg 1031641 ctgccatgct gcggcattgt tcagcacagg tgaagcaggc tttcgcacat gcttggcaat 1031701 gatcatgatc gtgctttccg cattcagtgc cgcatgcttc acaaatatcg gcgcaaagtg 1031761 cacaaatttc tttcataaac gggctgtccg tttgcatggc tttgaccgcc agcgcgcaaa 1031821 tatccgcgca ttccctgtca agccggatgc atccgctgag atgatgctgc acgctttctt 1031881 ccaagcattt agtgaaacaa tgattgcaag ccttcatgca atcgatgcaa gcctcaatac 1031941 aagcctcaga atattgctcc atggttgatt ccccctgtat gacagtatat ggttttatgt 1032001 ttcacggctg catttgaaaa aaacagggga gtgtgttttt agctaagggg atatgtacat 1032061 ataccctgaa tgggtatatc taacgttcca tcagatagta taggaaccag acagcgtgat 1032121 tttgttcatc acgtgctgcg cgcgtaaaga cgcctttcgc ttttaagttt gacgtttcct 1032181 cggccgcacg caagtaaaag tcgacggttt cttgttcatc tttaaaagcg gcgtccagtc 1032241 ctcttgtgaa attgtccggg cattcttccg tttgtttcgg catgatgtgt ttgccggtaa 1032301 ttgaaccata cagtgtggaa aattcacgga ggtggcgaat ctcgtcacgc ctgatttctt 1032361 caatctgttt tctgacctca tcgctgtggg cgagttcggc aagcttgcgg tagcattgaa 1032421 tagcactgaa ttctccgttg atggccttct gcaaattccg aatcaaaaca ggatcttccc 1032481 ggtatggcac cggataggga tagtagctgt aatgcaaggg gattcaactc cattcttagg 1032541 aattgggctt ctgtaaaagt atatgttggg cagggagaga tgtgcggaga taatcagctt 1032601 tttatatgtg aaaaggccgt ttttaccaat agatcagatt ggtcattttc gtcaacattc 1032661 gataaaatat agagagataa aaagagaggg gtcttctaat ttgggagcag agtttttagt 1032721 aggcaggtcc gggagtggaa aaacgaagct gatcatcaac agcattcagg atgaattgcg 1032781 ccgggctcca ttcgggaagc cgatcatttt tctagtcccg gatcaaatga cgtttttaat 1032841 ggaatacgag cttgctaaaa cgccagatat gggcgggatg atacgcgctc aagtgttcag 1032901 tttttcacga ttggcctggc gcgtcctcca gcatacggga ggaatgagca ggccgtttct 1032961 gacgagcacc ggcgtacaaa tgctcctgcg gaagctcatt gaggagcata aacaggagtt 1033021 caaagtctat caaaaagcga gtgacaaaag cgggtttacc gcacaggttg agcggatgct 1033081 gacagagttt aagcgctatt gtctggaacc ggaggatatc cgccggatgg cggaaagcgg 1033141 aacggcttcc gagtatcgcg gagaacgtgt tttatctgaa aagctccatg acttatcaat 1033201 tctgtatcag caaatggaaa aaagcctcgc agatcaatat cttcactctg aggattattt 1033261 gacattgctg gcagagcata tcccgcttgc ggaagatata aaaggcgccc atatctatgt 1033321 ggatggcttt tatcagttta ccccgcagga attcagggtg ttggagcagc ttatggttca 1033381 tgcggagcat atcacgtttt cgctcacagc ggacaagccg tcatatgagc gggagccgca 1033441 tgaactggaa ttgttcagaa tgacggggaa aacctattac cgcctgcatc agaaggcgaa 1033501 ggaactgaat ttggacatta cgtataaaga gctgagcggg actgagcggc atacaaagac 1033561 gccggaattg gcgcatctag aggcacagta tgaagcgcgt ccggccattc catacgcaga 1033621 aaaacaagaa gcccttactg tgatgcaggc cgcaaacaga cgagctgagc tggaaggcat 1033681 tgctcgggaa attcacgccc tagtcagaga gaagggatat cgctataagg atgtagcaat 1033741 tcttgcgcgc cagccggaag actacaagga tatggtgaag gaagttttcg cagattacga 1033801 gattccttat ttcattgacg gaaaagcatc tatgctgaac catccgttaa ttgaatttat 1033861 ccggtcgagc cttgatgttc tgaaagggaa ttggcgttat gaagcggtgt ttcgctgcgt 1033921 gaaaaccgaa ctgctattcc cgctcaatga accgaaggcc aaagtgagag aacaggtcga 1033981 tcagctcgaa aattactgta tcgcctatgg tattaaaggc gaccgctgga caaagggcga 1034041 tcggttccaa tacaggcgtt ttgtgtcatt ggatgatgat tttgcgcaga ctgatcagga 1034101 aatcgaaatg gaaaacatgt tgaatgacac ccgcgattgg attgttccgc cgctttttca 1034161 gcttcaaaaa cgcatgaaaa aagcgaagac ggttcaagag aaggcggagg cgctctatcg 1034221 ttatttagaa gagacggatg tgccgctgaa gctggatcag gaaaggcagc gtgctgagga 1034281 tgacggcaga atcattgaag cgcagcagca tcagcaggcg tgggacgcag tcattcagct 1034341 gcttgaggag tttgttgaaa tgatgggaga tgatgagatt tctcttgatt tgtttcagca 1034401 aatgatagaa gccggcgcgg agtcgcttac attttctcta attccgcctg cgcttgacca 1034461 ggtgtttgtc ggcaatatgg atttgtccag aatgtatggc acctcctgca cctttgtgct 1034521 cggggcaaac gacggcgttc tgccggcacg ccctgatgaa aacggggtcc tgtcggatga 1034581 tgaccgggaa tggctgaaaa cgattggggt tgagctatcc tcaggcggac gagagcgttt 1034641 gcttgatgag cacttcctca tctacatggc gttttcaagt ccgtctgacc ggctttacgt 1034701 atcgtatccg attgctgatg cggaaggaaa aacgcttttg ccgtcgatga tcgttaagcg 1034761 gctggaagaa ctgtttccgc atcataagga gcgcctgtta acaaatgaac ctgaacaggt 1034821 cagcgatgag gaacagctga tgtatgttgt gaataaaagc gtggcacagt cctttaccgc 1034881 gagccagctc aggttatgga ctcgggaata cgacatcagc gacgtctggt ggagcacgta 1034941 caatgtgctg atgagtgagc aggacaggct gcaatcgaaa aagctgttct caagcctgtt 1035001 tttccggaat gaagtgaagc agcttgaacg cagcgtgtcg agacagctct atggtgaacg 1035061 tattcagggc agtgtatcga gaatggaaac ctttaacgca tgcccgtttt cccattttgc 1035121 gtcacacggg ctgcatttga aggaacggca attcttcaag cttgaagcac cggatatcgg 1035181 ccagctgttt cattccagct taaagctgat ttcggacagg ctgcgtgagc aaaagctgga 1035241 ttggcgcgat ttaacgaagg agcagtgcga gctgttttcc tatgatgcgg tagagcggct 1035301 ggcaccgaaa ctgcaaaagg aaattctgct cagctcaaac cggcattatt atgtgaagga 1035361 aaaactgcaa aaaattgtga cacgtgtgtc cggcatttta agcgagcatg cgaaagcgag 1035421 cggattcgta ccgatcgggc ttgaactggg ctttggagga aaagggccgc ttccgccgct 1035481 gacctttcaa ctgaaaaacg gctgtacgat ggaactcgtc gggcgaattg accgtgttga 1035541 taaggctgaa agctcaaaag gcctgctcct caggattgtc gattataaat caagcgacaa 1035601 aggccttgac ttagcggaag tatattacgg attggcactg caaatgctga cgtaccttga 1035661 tttatcgatt acacattcag ctgactggct cgggatgagg gcgacgcctg ccggagtgct 1035721 gtatttccat attcatgacc cgatgattca atctaatctc ccgcttgggc ttgacgagat 1035781 tgaacaggag atctttaaga aatttaaaat gaagggcttg ctcctcggtg atcaggaagt 1035841 ggttcgcctc atggatacaa cccttcaaga gggacgttca aatatcataa acgccggctt 1035901 gaaaaaagac ggctctctca gatcagactc agcagcagtc ggtgaaaagg aatttgatct 1035961 tttgacaaag catgtgcgcc gcaccttcca agaagcgggc gaacaaatca ccgacgggcg 1036021 cgtatccatt gagccgtaca aaatgaagaa caagacgccg tgcacatact gtgcgttcaa 1036081 atcagtatgc caatttgatg aatcactgga agaaaacgag tatcgcccat taaaggctga 1036141 aaaggacaag acaatacttg agtggataaa aaaggaggcg gatggcaatg aacattccta 1036201 aaccggcaga cagcacatgg acagatgacc aatggaatgc cattgtttca accggccagg 1036261 atattcttgt ggcagcggct gcgggctctg gtaaaaccgc tgtgctcgtt gaacgaatga 1036321 ttcggaaaat caccgcggag gaaaacccaa tagatgtaga ccgtcttctc gttgtgacat 1036381 ttacaaacgc ctcagcggca gagatgaagc accgaatcgc agaagccttg gaaaaagagc 1036441 ttgtacagcg ccccggctcg ctgcatatta gacgccagct gtctctttta aaccgggcca 1036501 gcatttcgac gctccattcc ttttgcctgc aagtgctgaa gaaatattac tacttgatcg 1036561 atcttgatcc gggctttcgg atagctgatc agacggaagg cgagctgatc ggggatgaag 1036621 tgcttgacga gctgtttgaa gacgaatacg caaagggcga aaaggcgttt tttgagcttg 1036681 ttgaccgcta tacgacagac cggcatgatc tggatctgca atttctcgtt aaacaggtgt 1036741 acgagtattc ccgatcccat cccaacccgg aggcgtggct ggaaagcttt gttcatttgt 1036801 atgatgtatc agaaaagagc gccatcgagg agctgccgtt ttatcaatat gtcaaagaag 1036861 atattgcaat ggtgcttaac ggggcgaagg aaaagctctt gcgcgcgctt gagctgacga 1036921 aagcgccggg cggcccggcg ccgcgtgctg acaattttct tgatgatctt gctcagattg 1036981 atgaactgat tcagcatcag gacgatttca gtgaactata taagcgggtg cccgccgtct 1037041 cttttaagcg tgccaaagca gtaaaagggg atgagttcga tccagcgctc cttgatgagg 1037101 cgacagattt gaggaacggc gcaaaaaaac tgcttgaaaa gctcaaaacc gactacttca 1037161 cgcgaagtcc tgaacagcac ttgaaaagcc tagccgagat gaagcctgtc attgaaacgc 1037221 tcgtacagct tgtcatcagc tatggaaaac gattcgaagc tgcgaaacag gaaaaatcaa 1037281 tcatcgattt ttcggatttg gagcattact gtttagcgat tttgacagct gagaatgaca 1037341 aaggtgaacg tgagccgagc gaggctgcaa ggttttatca ggaacagttt catgaggtgc 1037401 tcgttgacga atatcaggat accaacctcg tgcaggaatc gattctgcag ctcgtcacaa 1037461 gcggtccgga ggagactggt aacctgttta tggtaggaga tgtcaaacag tcgatttatc 1037521 gattcaggct tgcggagccg cttcttttcc tctctaaata caaacggttt acagagagcg 1037581 gagaaggcac ggggcggaaa atcgatttaa ataaaaattt ccgaagccgg gctgatattt 1037641 tagacagcac aaacttttta tttaaacagc tgatgggcgg caaaatcggt gaggtcgatt 1037701 atgacgagca ggctgagctg aagcttggtg cagcgtatcc ggacaatgac gagacggaaa 1037761 cagagctgct gctgatcgac aacgcagaag atacggatgc aagcgaggaa gcagaagagc 1037821 ttgaaacggt gcagtttgag gcaaaagcca tcgctaagga aattcgtaag ctgatttcat 1037881 cgccgtttaa ggtgtatgac ggaaaaaaga aaacacatcg caatattcaa taccgagata 1037941 tcgtgatttt gctccgttcg atgccgtggg ctccgcaaat catggaggag ctgagagcac 1038001 agggcatacc ggtttacgcc aatttaacgt caggctattt tgaagcggtc gaagtcgccg 1038061 tcgcgctttc tgtgctgaag gtgattgata atccgtatca ggatataccg cttgcctctg 1038121 tgctgcgctc accgattgtc ggagcagatg aaaacgagct gtctttgatc cggcttgaaa 1038181 ataaaaaagc gccgtactat gaggcgatga aagactacct ggctgctggt gaccggagcg 1038241 atgagcttta tcaaaagtta aatacgtttt acggacatct gcaaaaatgg cgcgcgtttt 1038301 cgaaaaacca ctcagtatct gagctgattt gggaagtgta ccgcgacacc aaatatatgg 1038361 attatgtcgg cggcatgccg ggcggaaaac agcgccaggc caatttgcgt gttctttatg 1038421 acagggcgcg tcaatatgaa tcaacggcat ttcgcggctt gttccgtttc ctgcggttta 1038481 tcgaacgcat gcaggagcgg ggcgatgatc ttggtacggc gagagcgctc agcgagcagg 1038541 aggatgttgt ccgcttaatg acgatccaca gcagcaaagg gctcgaattt ccagtcgtgt 1038601 ttgtagcagg tctcggccgg aatttcaaca tgatggattt gaacaaatcg tacctgctgg 1038661 ataaggagct cggatttggc acgaagtata ttcatccgca attacgcatc agctatccga 1038721 cacttccgct cattgcgatg aagaaaaaaa tgcgcaggga gctgctgtca gaggaattgc 1038781 gtgtgctcta tgttgcatta acgagagcga aggaaaagct gtttctgatt ggctcatgta 1038841 aggatcatca gaaacagctt gcaaaatggc aggcatccgc gtcccaaact gattggcttc 1038901 tgccggaatt tgaccgctat caggcgagaa cgtatctaga tttcattggg ccggctcttg 1038961 ccaggcacag agacttgggg gatttggctg gtgtgccagc acacgctgac atctcaggtc 1039021 acccggctcg ttttgccgtt caaatgatcc attcctatga tttgcttgat gatgatctgg 1039081 aagaaagaat ggaagaaaaa agcgagcgcc tagaagcgat ccgccgaggt gaaccagttc 1039141 ccggctcgtt tgcgtttgat gaaaaagccc gcgagcagct gagctggacc tacccgcatc 1039201 aagaagtgac gcaaattcgg acaaagcaat cagtttctga gatcaagaga aaaagagagt 1039261 acgaggatga atacagcggc agggcccctg taaaaccggc tgatggaagc attctgtaca 1039321 gacgtcccgc ttttatgatg aaaaaaggcc tgacagcggc agagaaaggg actgccatgc 1039381 atacggttat gcagcatatc ccgctgtcac atgtgccgtc gatagaagaa gctgagcaga 1039441 cggttcacag gctttatgaa aaagagcttc tcactgaaga acaaaaagac gctattgata 1039501 tagaagaaat cgtgcaattt ttccatacag aaatcggcgg acagctgatc ggtgctaagt 1039561 ggaaggaccg ggaaatacca ttcagcttag cgcttccggc caaggagatc tatcctgatg 1039621 cacacgaggc agatgagccg cttttagtgc agggtattat tgactgtctc tatgaaactg 1039681 aggacggatt atatctattg gattataagt cggaccggat tgagggcaaa ttccagcatg 1039741 gatttgaagg agcggccccg atcttgaaga aacgatatga aacgcaaatt cagctgtaca 1039801 cgaaggcagt ggagcaaatt gcaaaaacaa aggtaaaggg atgtgcgctt tatttctttg 1039861 acggagggca cattctgaca ttatagcgag atccataagc tccggaattt caggcggagc 1039921 gggtctcgtt ttctatataa aagagaggtg aaagcatttg cggattttac atacggctga 1039981 ctggcatctt ggaaaaacgc ttgaaggaag aagcaggctg agtgaacagg ccgatgtgct 1040041 ggatgaactg aatacgattg taaaggatga gcagatcgat gccattgtaa tggcggggga 1040101 tgcatttgac accgtaaacc cgccagcttt agccgagcag ctgttttatg aaagcctgtc 1040161 tgcgcttagc gacagaggaa agcgcccgat cgtcgtcatt gccggaaatc acgataatcc 1040221 tgaccgtttg tccgccgctt caccgctgac acatgaaaac ggcattcatt taatcggtta 1040281 tccgacaaca gagccgattc atattgaagt gccttcagca ggagagcttt tggcggttgg 1040341 agcgctggcg tacccatctg aagcgcggtt aaatgaagtg ctatccgata cgtttgatga 1040401 aaagctgctc cgtgatcact atgatgtgaa aatcaggcag gcgtttgagc atatgacaag 1040461 ccggttccgg accgatgcag tgaagattgc cgccagccat atttatgtgg caggcggaaa 1040521 ccaaaccgat tcagagcggc cgattgaagt cggcggtgca tacacggtgg ctgctgaaag 1040581 cctgccggca gatgccgctt acgttgcgct cggccatttg catcgcccgc aaacgatcaa 1040641 gcgggcgcgg acgcttgcgc gttattcagg atctccgctc gcctacagct tttctgaagc 1040701 gggctacgct aaatcagtga cgattgtgga cgcaaagcct ggggaagagg ccacttggca 1040761 agaggtgtta ttatcaagcg gcaagccact tgtgaagtgg aaagcggcaa atggattaag 1040821 tgaggtgtac agctggctgg atgaaggcag agatcagaat gcttggattg acttggaaat 1040881 ccgtgtcgcg gaccagctgt cacttgaaga gattcacagg ctgcggaagg cgcacccggg 1040941 ctttatccat atcaggccgg tttttgaaga acagaacaaa gaccgggaac ggatcgaggt 1041001 taaacatgtc tcaatcgagg accgctttaa gaaattttat gaaaaacaaa ctggcggtgc 1041061 ggtgccggat gaagaaatgg tgaagctgtt tttagagctt gcatcaggcg ttgaagagga 1041121 ggatgcgaaa tgaagccgat cgccttaagc attaaggggc tccacagctt tagagaggag 1041181 cagacgatag attttgaagg cctttccggt gccggtgttt tcggcatttt cggcccgaca 1041241 ggaagcggta aatcctctat actcgacgca atgacgcttg ctttatacgg aaaggtggaa 1041301 cgggcggcga ataatacgca cggaatctta aatcacgccg aagatacgct gtctgtgtcc 1041361 tttacctttg cgcttcagac gaatcaccaa atctcataca aagtcgagcg tgtgtttaag 1041421 agaacggatg aaatgaaggt aaaaacggca ctttgccgct tcatcgaaat caaggacgag 1041481 catacggtgc tggctgataa agccagcgaa gtgaataaaa gagtggagga gctcttaggg 1041541 ctgacgatcg acgattttac gagagcggtg gtgctgcccc aagggaaatt tgctgaattt 1041601 ctgtctttaa aaggggcaga gcgcaggcat atgcttcagc gtttatttaa tttggagcaa 1041661 tatggagaca ggcttgtgaa aaagctgaga cggcaggcgc aggaagccaa tgcgagaaaa 1041721 aatgaaatgc ttgctgaaca gtccggtctc ggtgaggcga gctcagaggc agtggagcag 1041781 gctgaaaagg ttctcgaaca agctgaagcc cggctggaag cgatgaggaa gaaccgtgat 1041841 caggcgaagg agcggtttac agagcatcag gagatatgga atgtccaaaa ggaaaaatcc 1041901 acttatgaag aagaggaaaa acgtctcgca gaagaacagc cgcatataga cagcatgcaa 1041961 aaacgcctgc tggaagcaga aacagcagca gcccttaagc cctatgcgga ccggtacgca 1042021 gaagcgatcc agcatgagga gcaagctgaa aaggaacaaa cgctagccca aaaggattta 1042081 gcagaccgga cagctttctt tcagcaaaaa catgaagagt atgaagcgtg gcgccagcat 1042141 aaaagcgaga aagagcctga gcttttagcc aaacaggaac agctttcacg cttgcaggaa 1042201 atcgaaatca aactgagtga ggccaagcaa gaggaagagc gcaaaaaggc tgacctccgg 1042261 cagaaagaag aggctcttca atctgtcatg aatgaattag agaccgtaac agaccgcctg 1042321 acacgagggc aaaacagaca gacagaattg aagcagcagc tcaaatccct gcaggtgaca 1042381 tccgatgagc gaaaaagctg ccagcaggcc gcagagatgg cattgcgcat cagacaaacc 1042441 gaggaacaaa tcaaaaaaga gaaaaaacga agtgaagaat tgaacctcgt gctgcagaag 1042501 atgaatgaag agaagaatac actcgttcaa aagacggaag cggaagaaaa caacatcatt 1042561 caggcatatg aggcagttca aactgtgtac catttggtgt gcgaaacgga acgctcatta 1042621 acacgtatga cggaagaggc tagaaagagt caacacacgc ttcacttaca gcgtgaaaaa 1042681 gcaagggtgg cactgctgac aaaagagtta gcccaaaagc tgactgccgg aaagccttgc 1042741 ccggtatgcg gttcaaccga tcatgatcca tctgcctcgg tacatgaaac gtatgaagcc 1042801 gacagccatc ttgaagagga catcaaacgg acagatgtgt tattgacgga agctgcagct 1042861 ctcagccagg agattctttc agccaaaatt atgcttgaag aacagtccgc gcgctttatt 1042921 gaacagtgtc cgtttttgca gacaattcaa gcacagaacc ttgaagcggc agcttccttc 1042981 gaacatcagc cggtgtatga agcatttgaa actgccaaat ttgaatggaa acgaatcaag 1043041 caggacattc tttctgttaa gacacgaatg gcacaaatga ttggcgccta tcaggagtct 1043101 ttaaaaaagg ccgagcagct taatgaaaaa atcggttttg aaaaaagaga agccgaccgt 1043161 attgaaagca tcatcagtga gcttcaatcc tcaatggaca gcagtctgaa catgtttaaa 1043221 gaagcatttc agaatcaatc tgtggacgaa gcagaaaaat ggcagcaagc cattgaagaa 1043281 aaggaccggg ctgcagaaga atgtgaaaaa cgaattgaga agagtatcgc gtttcttgct 1043341 gagcatgaag cacaaaagga aaaactgcgg gaatcgggac accggcttga gcgggaaaag 1043401 ctggagcttc attatgcggc tgaacgcatc aagagcgtga tagctgatta tgagcacgaa 1043461 ctcggagatt atgcaaaagg agattcgatt caaatcaaac tccgctctgt ccagcaggat 1043521 ctaaagctgt taaaggaaaa agaacaatct ttatatgaag aactgcaaag cgcccaaatg 1043581 aagctcaacc aagcgaaaag ccgcgcttct gcaagcgagc tcactcttca agaggcgaag 1043641 ggcagattgg aaaaagcaaa agctgcttgg cttgagcata caaaaaacac ctccattacc 1043701 cggactgagg aggttgaaca aagtctcatc ccagctgatg aacttgaaaa gatgaaaacc 1043761 ggcatagacc agtttatgga taaactgaag caaaatgctg caaacttaaa acgagtagca 1043821 gagatacttg ccggcagagc attatcagag agcgaatgga acgaaaccgt tgcagcatta 1043881 caagaagctg aggacgcatt tggcgctgct atagaggaaa aaggcgcggc cgcaaaagca 1043941 ctggctgtca ttcgcgacca tcataaacgg tttaatgaaa ttgaagctga actgaaaaaa 1044001 tggcagatgc atatcgacag gctggacaag ctgcaagctg tgtttaaagg caataccttc 1044061 gtcgaatttt tagctgagga gcagcttgaa agcgttgcga gggacgcctc agcaagactc 1044121 agtatgctga caagacagcg ctatgccatc gaagtagatt ctgagggcgg cttcgtgatg 1044181 cgggatgacg cgaatggagg cgtacgacgc ccggtttcca gtttgtctgg aggagagacc 1044241 ttcctcacct cgctttcact tgctcttgcg ctgtctgcgc agattcagct tcggggggaa 1044301 tacccgctgc agttcttttt cttagatgaa ggcttcggca cactggatca agatctgctt 1044361 gatacggttg taacggcctt ggaaaaactt cagtcagaca acctggctgt cggtgtcatc 1044421 agccatgtgc aggaactgcg tgcacggctt ccgaaaaagc tgatcgtcca tccggctgaa 1044481 ccgagcggcc gcggtacgcg ggtatcactt gagttgatgt aagggaggag cggatatggc 1044541 aaagcagatt gccggaatat gtgagctgtg cggccggagc gatgtccagc tgacagagca 1044601 tcatcttaca ccgaaagagg aaggcggaac gtttttgccg acagcgatgc tctgtattcc 1044661 ttgtcataaa cagattcatg ccttatatac caatcaagag ctcgctgtac gtttaaatgg 1044721 aatggctgaa ctcagaagcg atccagagct tgcccggttt gtcaaatgga tcagaaaaca 1044781 gccgcctgag aagctgatca aaactaagaa atcaaatgaa cgaaaaaaga aaaaatgact 1044841 aaaaagcagc cctctctttg cagagcggct gcttttatcc gtttccaacc atatccggaa 1044901 gcaaaagttg ttgttgaaaa gtaaccaaaa agcggtgctc gatgcaccgc ttttttattt 1044961 gcgcccccgt tggactgctg tgtacataat ggatcgcttt ccgtttgaag ccgtccattc 1045021 aaaacggtct cctgtccctt cgctgctgta gttgtagtga tgctgcatcg cgcattgtgc 1045081 ggtgtcattt gaaaagtgat aaaaggacac accctgcccc gccgaagtat tcgaaaagac 1045141 tcctttatta taagaaaaga cgcaatcgaa taccgataag ccgaagctgt gcaagtgctg 1045201 cagaaatgcg agaaaggttt cgtcgtcaag cgaatccaaa agcgccatga gcggccgctt 1045261 gactgatttc tcatagcgga tgcgttctcc gccggaaagg gagatgtttt ctgcaccgca 1045321 tgccaaaacc aacttgtcct gaaagccggc ttgctcccac tttcctttat gatggatcca 1045381 gattgggctg tgttggagac tgtccgccag cagtatatcg ccttcaccgt tttcgattaa 1045441 gcagatgccg tcttcaatga ggatggtgcc gtattcccac tttcgttcct ctgtatataa 1045501 caattgtttc cgtttcatcc atgctgtctc ctttttcttc attcctctct tttctttcca 1045561 attcaagcct gtcccataca actcttttat ggacaaatca actatctgcc tatagatgca 1045621 taaacttact aaggtgctga aagaaacgaa attgttacga aagaaacggg attggagctg 1045681 atgtcacatg tgtggaatta cgggttgggt cgattttaaa aagcagctcg tccaggaaaa 1045741 acaaacgatg gacagaatga cagacactct ttccaaacga gggcctgatg attcaaacgt 1045801 ttggggggag caccatgttt tattcggaca taaaagactt gcggttgttg atattgaagg 1045861 cggacgccag ccgatggcgt gtacctataa aggcgatacg tacaccatta tttacaatgg 1045921 cgagctttat aacacggaag atttgcgcaa agaattgcgg gcgcggggcc atcaattcga 1045981 gcgtacgtca gataccgagg tgcttctgca cagctacatc gagtggcagg aagactgtgt 1046041 cgaccatctc aatggcatat tcgctttcgc tgtgtgggat gaaaagcgta atctgttgtt 1046101 tgccgcgaga gaccgtctcg gtgtaaagcc gtttttttac acgaaggaag gctcttcatt 1046161 tctcttcggg tcggaaatca aagcaatcct cgcgcaccct gatataaaag cgcgagtgga 1046221 cagaacggga ctttctgaaa ttttcggtct tggaccgtcc agaaccccgg gcactggcat 1046281 atttaaaggc ataaaagaaa tccgcccggc tcacgcgctg acattttcca aagacggact 1046341 taatatttgg cgttattgga atgttgaaag cgaaaaacat acggacagtt ttgatgacac 1046401 ggttgccaat gtcagatcgt tatttcagga cgcggtgacg cggcagcttg tgtcggatgt 1046461 gcctgtttgc acattcctat caggcggtct ggactcaagc gcgattacag cgattgcggc 1046521 gggccatttt gaaaaggaag gaaaagcacc gcttcatact tattcgattg attacgaaga 1046581 gaacgataaa tattttcaag caagcgcttt tcagccgaat gatgacggac catggattga 1046641 aaaaatgaca gaggctttcg gcacaacgca ccacaaatgc gtcatcagcc aaaaagacct 1046701 cgttgatcat ttggaggaag ctgtactggt caaagacttg ccgggaatgg cagatgtcga 1046761 ctcatccctg ctgtggtttt gccgggaaat caaaaaggac tttgtcgtca gcctatcggg 1046821 agaatgcgcg gatgagattt tcggcgggta cccgtggttc catacggcag atgttgagtc 1046881 tggctttcca tggatgagat caacggagga gcggatcaag ctgctttctg actcatggca 1046941 gaaaaaattg aatctgaaag aatacgtaaa tgccaaatat gaagaaacct tggcagaaac 1047001 gccattatta gacggagaaa cgggtgtgga taaagcaaga agacagctgt tctatttaaa 1047061 tatgctttgg tttatgacga accttttgga tcggaaggat cgcatgagca tgggggcgag 1047121 cctggaagtg cgggtgccgt tcgccgatca ccggcttgtg gaatatgttt ggaatattcc 1047181 gtgggaaatg aaaatgcatg ataatcggga aaaaggcatt ttgcgcaaag cgcttgaggg 1047241 cattttgcct gatgacattt tgtatcgcaa aaaaagccca tatccgaaaa cacatcatcc 1047301 ggaatataca aaaggcgtca gcgagtggct gaaaacgatc agaagccaaa aggactccgt 1047361 gctccatacc ttactggaca gaaaacaatt agatcagctt ttagaaacgg aaggctcctc 1047421 cttcaaggtc ccgtggttcg ggcagctcat gaaggggcct cagctgatcg cccatcttgc 1047481 tcaaattcat acatggtttg aagcgtatcg cattgatatt gacgagaggt aggttcaata 1047541 caaatgtgat taaaagccag agatgtatag atttaaataa gaaggataga tgagcaggga 1047601 aatatatgct ctatctatcc ttttttgtac aacagcacta tcgaattgcc cccgcattcc 1047661 ttcaataaga atgaataggt tttaatgttc tgccgataaa actagctgat accgggctta 1047721 actttaattc cctagcccat acagaaagtt gaccaatatg gtgaatttcg tgagcgatga 1047781 tatggtgtaa tatttcatct cgcgtatata aaacacctgt ctcccaagga acgcttacaa 1047841 gttcatcttt tatttgatct gaatgtgttt gtaaaacatc aattatttca gttcggaatg 1047901 tatttgagag agatttcact ttattgagtg tttgataatc agcgaactga acagcgatat 1047961 cttcttttcc ttggatagca cgaatccaac tatattccac atcaataata tgaaaaaggg 1048021 tatataaaat attctctact ccgccaagac gatttttaag taattcttca gtggttagtt 1048081 gatgacacca agtaaaccat tgatctctaa cctgccagtt atattcaaaa aatttcatca 1048141 ctaaactcac tccaatacta tcatgtatca taacaattag cccttttttc cgtgattcct 1048201 ctattaatga agtgatgatt gagaaatgtt tacattctac ctgttgtatg gcattaaaaa 1048261 taataatgca tatctcgtcg atgatgctgt gcgtcttgtt acttttacaa agtaagaatc 1048321 ggcattttct tcatatacaa ttaggaaaaa acatactaga cttgaagaag cagtgataca 1048381 taggagtgag aaaatgaaag agataaaaga agcttaccag caatgcggac agattgttgg 1048441 cgaatacgcg ccagcctgtt tcaaagcatt atcatatctc ccgctaaagc aaagacaagc 1048501 ctcttgggca gtattgtcgt tttgccacac ggcggccagt gcagacgaaa aggtattgcc 1048561 cgcatttgaa gctaaagctg atcatgttta ccaaaggaca aataacggta aacaacatct 1048621 atggaaggct tttgatcatg cgtatcggac ctttacattg gaaagcgaac cttttcggga 1048681 gtttattgcc gcacaaaaag aagacgccaa gccgtatgat gaccttgatg aactgctcat 1048741 gtacgcatat cggacgggcg gtgctgccgg attgatgctg ctgccgatac tgacacgccg 1048801 aaaacaagat cagctcaaac aagcagccgt ctctctcggc ttggccatac agctggttcg 1048861 cttcttaagt gatcttggca cagatcagca aaaaaaccgc attccccgtc aggtaatgca 1048921 gcaattcggc tatacagagg ctgatctcca aaaaggcacc gtaaataaag cgttcacaat 1048981 gacgtgggag tatatcgctt ttgaagcaga agcctacctt gaagagtgtc aggatgcctt 1049041 gccgctattt ccgcagtatt ctcaaaaaac ggtgaaagcc gctcttcatt tgcaccgggc 1049101 tgttttagaa aaaatccggg cgaagcagca cgatgtattt caatatcact tcgctctcac 1049161 agagaccgaa gtgaagcaga ttctgtctga tatctaaaaa acacccggcc ttgattgagc 1049221 cgggtgttac gccatacctt tttgaatcca gatacgtgag cgccatcttc tgtacattaa 1049281 gattccccgg acccattcat ccgcgataaa agaaatccaa atgccggcaa gaccgaaacc 1049341 gaggtggatg ccgaaaagat aagcaagcgg gaggccaatg ccccacattg aaatcattgc 1049401 catgtaaacc gggaatttcg catcccccgc ggcccgcaga gagttaatga taatgacatt 1049461 aaacgagcgg cctggttcaa ggataatggt catggcaatc aataggcttg cagttgctat 1049521 aatgtcaggg ctttgtgtga agagtccgat caggtctttt gaaaagatcg tcatcaaaac 1049581 agaggtagcc gcagcaattc cgagtgccca atataagctc ttcatgcagc gctcataagc 1049641 ggcatcaaat tgtttgccgc cgatataacg gccgattaag atttgtgtac cctggctgat 1049701 cgcagtgccg aacagcaaaa taaacatcgt aatattttgc gtatacactt ttgttgtcaa 1049761 cgcctgcgcg cccatgatgg cgataaaata cgtgactatc atttgcgaca ggttgtatga 1049821 aagctgctct cccgcagaag gaatgccgat tttcagcagc ttgcgcaaat gctctttatg 1049881 catatgaaag acttttttca gcgacatctt cagctggatg cgtttgttga caatcacaat 1049941 catcgcgatt aatccgatga cgcgggcgat agatgtggac atggccacac cggcaacacc 1050001 gagaacagga aagccgaaca aaccgaaaat cacaacaaag tttccggcaa tgtttaaaat 1050061 gttcatgccg atagtgacaa acattgtatc ttttgtgtag ccgtagcttt ttaagatcgc 1050121 gctgaatgtc atgattaaag cctgaataaa ggacagacct ccgacaactt gtaaaaagac 1050181 tttcgcatca ggcatcagtg cgtctgataa tcccatcata tgaagcagag ggacagccgc 1050241 gaaaaagacg acggcgctga tggccaggct gatgaagaag ttggcgccga ttgacacata 1050301 agcgacttcc atggcttctt tcttttgccg tgagcctaga aattgtgaaa tgataacggt 1050361 cgttcctgtt gcgataaagc tgaacatcac gataattaaa tttaaaatct ggttgctgac 1050421 gccgactgct gccacgctgt tatccgagta ttggctgagc atcagtgtat cggcattacc 1050481 cataaacata tataatgaga cctcaataaa gatcggccaa gtaagcgaaa ataatgagaa 1050541 cgttttgtca gcgggttttt tcaaagcagt tgatttgaag acagcttgtt tcatcgtgtc 1050601 taaccccttt cgtaaataaa atcaacgttt taaagtgtac ctccatttcc ttataataaa 1050661 aagggataga aacgatactt cttgtaaaaa tccgacttaa aaaggaggat gattcaaatg 1050721 cctcgcatcc tgtttacagt cccgcctttt ccggtattta tcgcagctgg ggaaggggtt 1050781 tttaaaaaag gagaaaccca tgtgaaacgt gtattctccg tgtttgatct gatatatgtc 1050841 aaacagggaa cgttatatat aacggaaaat gaaacatcgt tttctgttga aggcggcgag 1050901 tacatcttgc tttctcccgg tcttgaacac tacgggacga agggcagtga tgaagcaacc 1050961 tcctactatt ggcttcactt cgatgaacat cgatatgaat ttacggcaaa gggaggcagc 1051021 aactggtctg agcttcagca ggaaaaaggg agcttcgaag agctggcccg ctacggattg 1051081 gccttgccga gaaaaggcaa ggtgcagcgc ccgcagttta tggcgcagca gtttgaaaag 1051141 ctgatcgatt actccgcgga aaactctgat ttgccgctca gaaagcaaat tttatttgag 1051201 gagctgatgc tgcatcttca aaaagaagcg ttccaaatac cgtctgcgaa agagcgggta 1051261 gcctgggagg cggcccggta tttacaggag cactataagg aaaagacgac aatcaaggat 1051321 ctgtcgctcg cccttcacta tcatcaggat tatgtgagcc gctgcatgca gcaggtgctc 1051381 ggcgtaactc cggcacaata cacgaaccgg gtgagaatga cggaagcgaa gcgtctttta 1051441 tcctctacaa atgataaaat gggcgttatt gcggaaacgg tcggaatgga agatccgaca 1051501 tacttttcaa aactctttaa gcagatagaa ggcatttcac caattgaata ccggaaaatt 1051561 gtcagccgga aagttcaata accagacgag ggatgaacat gaaaacaaca atttacgatg 1051621 tggcaaaggc ggcgggtgtt tcgatcacaa ctgtgtcccg tgtgataaac aatacgggga 1051681 gaatcagcga taaaacacgg cagaaggtca tgaatgtcat gaatgaaatg gcatacacgc 1051741 ccaatgtcca cgccgcggcg ttaacgggaa aacgaacgaa tatgatcgct ctcgtggcgc 1051801 ctgatatttc aaatccgttt tacggcgaac tggccaaaag cattgaggaa agagcggatg 1051861 agctcggttt tcaaatgttg atttgcagca ccgattacga tccgaaaaaa gaaacaaagt 1051921 atttttctgt gctgaaacag aaaaaggtgg atggcattat ttttgcaaca gggattgaaa 1051981 gccatgacag tatgtctgct ttggaggaaa tcgccagtga acaaattccg attgccatga 1052041 tttctcagga taagccgctt cttccgatgg atattgttgt gatagacgac gttcgtggcg 1052101 gatatgaggc tgccaagcat cttctgtcac tcggccacac gaacatcgcc tgcattatcg 1052161 gagacgggtc aacgacaggc gaaaaaaata gaatcaaagg cttccgtcag gcgatggagg 1052221 aagcgggcgt gcccattgat gaatcactta tcatccagac gcggttttcc ttggaaagcg 1052281 gcaaggaaga agcgggaaaa ttgctcgaca gaaatgctcc gactgctatt tttgccttca 1052341 acgacgtatt ggcttgtgcc gccatacaag ctgcgagaat aagaggcata aaagtgccgg 1052401 atgatctttc tatcattggt tttgataata cgatactcgc agaaatggcg gctccgcccc 1052461 tgacaaccgt agcccagccg ataaaagaga tggggcggag cgtcatcgaa ctgctggcag 1052521 aagcaataga gggaaaacga aaggcgaaac aaaaaatagt gctcccgcct gagcttgtag 1052581 tcagacattc tacatcaccg ctcaacacat gagcccgcta atgagcgggt tttttcatta 1052641 tgacagttga agccaaaaaa acatattgcg tgtaaaccaa aggcggtgta aaatataacc 1052701 atcttttgag aaagcgcttg cgcaaaatgg cagagcggat agaaccgctg tttttttagc 1052761 tgttaagaga aaacgctttc tcaaagcgag cccgaaatga gataaaggag aggatgggac 1052821 gtggaacatc aagtaagatg tgcagtattg ggattaggaa ggctcggtta ttatcatgcg 1052881 aaaaatctcg tcaccagtgt gccgggggca aagctggttt gtgtcggtga tccgttaaaa 1052941 gggagagcgg agcaggttgc cagagaactc ggtatcgaaa aatggtcaga ggacccgtat 1053001 gaagtgttag aagatcccgg cattgatgct gtcattatcg taacgccgac aagcacacat 1053061 ggtgatatga tcatcaaagc agccgagaac ggcaaacaga tctttgttga aaaaccgctg 1053121 acattaagcc ttgaggaatc aaaagcagct tctgaaaaag ttaaggagac aggtgtcatc 1053181 tgccaagtcg gctttatgag acggttcgat cccgcatacg cagatgccaa acggcggatc 1053241 gacgctggag aaatcggcaa acctatctat tataaaggct ttacgcgcga ccaaggcgcg 1053301 cctcccgcag aatttatcaa acacagcggt ggaattttta tcgactgttc catccatgac 1053361 tatgatattg cccgttattt gctaggggcg gaaatcactt ctgtttcagg acacggcagg 1053421 attctgaaca atccgtttat ggagcagtat ggcgatgtgg atcaggcgct gacgtatatt 1053481 gaatttgact cgggcgcagc gggggacgtc gaggcaagca gaacctctcc atacggacat 1053541 gacatccggg cggaggtgat cgggacagag ggcagtattt tcatagggac attgagacat 1053601 caacatgtga ccatcctatc ggctaaaggg agcagttttg atatcattcc agactttcaa 1053661 actcgttttc atgaagccta ctgcttggag cttcagcatt tcgccgagtg tgtccggaat 1053721 ggaaaaacac cgattgtgac tgatattgat gcgacgatca atttagaagt gggtatcgcc 1053781 gcaaccaatt cctttcgaaa cggcatgccg gtacagctag atgtgaagcg cgcttataca 1053841 ggtatgtaaa agctaagtat gttgcatttg aggctttccg caaaaaaagc aagggcattt 1053901 tagcccttgc tttctctttt ctcatataaa tagtacatat aatcagtagg tacgcctgaa 1053961 tggtccagct gtctcagcat ggcggttacg ttccctctgt ggtaagtgcc gtgattgacg 1054021 acatgcagga tggtgtctgc ataggttgat tccagtgtac ctagtttcgg atgctgcatt 1054081 gtgaaggtct gttctaagtc cgtctggcgg ctgaagaaat catgatactg tgactccagc 1054141 tcggcagcgt gctgtttaat cgctgccata ttaccttgcg cggactgtaa tttgcctgcg 1054201 ctgtctataa tctcttggta ggccactccc gaaagaacat tcagccaaat gtagtcagcc 1054261 ctgcacatat gaagcagcac gtcgctgaca gaaggaaata cgctctttac ttcttgatag 1054321 gcagtttcct ccggcaggtt ttcgatatgg gtaaatattt tcttgtttgc ccaagaatga 1054381 tagtcataaa actgttttgc atcagtcatc agcatgcccc cttttctaag aaattcgttt 1054441 ttttcatctg tttctccttc aattgcaaaa gagtgacacc ccaaaatatc ctgccgctgc 1054501 ccacattacc gctgcagagc atttgtttac gatcagcata agcctgccgc tcgtatctat 1054561 cgtctgaaac aaccggcccg ctattgcaag gctgatgaac caaatccaag acacagcgat 1054621 gcaggcggcc ataaagagcc atttctcaag ccccgaatat tgaagagagc tcgtgccgat 1054681 gacgccgatc gtgtccagaa tggcatgcgg gtttaaaaga gaaacagcgg ccgcaaacgc 1054741 agcttgcttt tttggtgtga acgtatgttt ctcattttgg cttgtgttcg gacggatgtt 1054801 ccaagtcacc cagcccatat aaagcaaaaa taaaaatccg ccggccatca tgactgtctc 1054861 aaacacaggc agctcctgca caatgacaga cacgcccgca acggctaata caattaacaa 1054921 ggtatcgcag actgaagcac tgatgacagc tgggagagcc cgccaaatat gcttttgcaa 1054981 cgcgccttgc tgaaaaataa acacattctg cactcccagc ggcaaaatta agccaaacgc 1055041 gagcacaatt ccgtgaatga ttgcattcat gctgaaaaag ctcctttcac attttttttc 1055101 aatcataaga gagattgtca ctaaagtctc cagccatttg gttgggttag gaaccagcca 1055161 aatgtataat gtgtaaaaaa ggggggcatg accttgtcgc aatggcagcc aagccgaaag 1055221 tcggatgttc cgctgcatcg gcagatcgaa caatatatga aagacaagat tcttcacgga 1055281 gagtgggctg tagggacgaa aatcccctca cagagaacgc tggccgacat gtttcaagtc 1055341 aaccgcagca cagtcacagc agccatagat gaactcacgt ctcaaggctt gttagaggga 1055401 agaaaaggcg gcggtacgaa ggttgtaaac agtacttgga gcgtgctgac ggctgagcct 1055461 ccgcttgatt ggagcgatta cgtccgttcg ggcattcatc gcgccaattc ttccatcatt 1055521 caagctatta atcagaacga accaagagcg gatatcatca gattaggaac tggagaactt 1055581 tcaccggatc ttgtgcctgc tgacacaatt ggacggatgt ttcagcaaat caatccgggc 1055641 gtcctgtctt taggatatga gcagccgaaa ggaaaccgtc agctgcggga ggcagtggcc 1055701 gaccatttaa aaggaaagaa gatccatgtg tcaccgtctg caattttaat tgtgtccggt 1055761 gcacttcagg cacttcagct catctcaatt ggacttttaa aacgagattc tgtcattttg 1055821 acggagaagc cgtcctacct tcaatccttg catgtatttc aatcagctgg gatgcggctt 1055881 cgcggcttgc cgatggatga tgaaggggtc aaagcggggc ttgtttcttc taatcgaaaa 1055941 caatatggag gacagctgct ttacacgatt ccgtcgtttc ataatccgac aggcacagtc 1056001 atgtcagagc agcgaaggaa agagatcatc agcctgtcaa aaaaagagca gatgcccatc 1056061 attgaggatg atgcgtacgg tgatttatgg tttgaagaaa aaccgccgca gccgttgaaa 1056121 gcaatggatc atgagggcaa tattctgtat ctgggcgcgt tttcaaaaac ggttagcccc 1056181 ggtctgcgaa tcggctggct tgccggtccg gagccggtta ttgaaaggct ggcggacatt 1056241 aaaatgcaga cagactacgg atcaagcggc ctgtcccagt gggcggctgc cgagtggctg 1056301 tcacagggat attatgaaga gcatctgact tgggtacgca ggaagcttaa agaaaggaga 1056361 gacgccgccg ttcattttct cgagcggtat gccggggaca ttgccacgtg gcggattccc 1056421 gcaggcggct tttatatttg ggtgacattt cacaaaaacc tgcctgtcag ccgtttcttt 1056481 tatgaattgc tgaaacggca ggtgcttgtg aatcccggct atatttatga cggtgaagac 1056541 cgaaacagca tcaggctgtc atattcctat gcatctcttg gagatttgga aactggcatt 1056601 aaagcggcag ctgaaacagc acgccgcctg atgatgtcct aggctttggt tatacgatga 1056661 cagctcccag tgccctggcg aaggcaatcg cgtgctcagg tgcgattttg cagcctttca 1056721 atttgtcgag ggagacatga agctgttcaa aacggcacgt gctgatgtcc atgttttgaa 1056781 gggacgtgcc ggtaaagctg gcgccttcca attcgcatcc gtcaaagtgt gtctgctgga 1056841 gcaccgtatc gctgcattca ctttgcataa gagcacagtg atcaaatcga acttgtttca 1056901 tatttgagta cgaaaatgag ctgaaatgtc cgtggcattc ctcgaatgaa acattccgca 1056961 gcgttgcttc cgccacattc attccaacca tttttgactg cttaactgaa gttctgtgaa 1057021 tgacagcccc gctgaaatcg gcgtttgata aatcgcattt ttcaaagatc acatcggtca 1057081 gttcaatatg ccgaaaagac acatcgataa agacgacatt tctgaatacc gttttttcaa 1057141 cacatagtct ttcgatatct tcgccgcaga tggtgcaatc ttcaaacaaa tgcatgctga 1057201 ttacatcatc ctgtgtcacg gcatcatgaa aatctgcggt ttgcaggttt tccggtatgt 1057261 tcggtttttg aattgcgatt ttattcatgt gatgacatcc tttgctgccc gaaaaacaga 1057321 ggcttccggg ttcaatttaa tagatcgtta aggaaattga tacatatagt aaatcgtgaa 1057381 gagccttttc ttggtacagc agcccgcttg ttttgtaagc ataaatggaa agcttcctat 1057441 acgtcaaggc gtttacaggc cgaaaaagcc aaagggaaca ggaggaatgc ggaatggggc 1057501 attacatcaa aaccgaggag catgtgacac tgtttgtaga ggatatcgga catggaaggc 1057561 cgatcatctt tttgcacggg tggccgttga atcataagat gtttgaatat caaatgaatg 1057621 agcttccgaa aaggggattt cgttttatcg gcgttgattt gcggggatat gggcaatctg 1057681 accgcccttg ggaaggctac gattatgaca cgatggccga tgatgtgaaa gcagtcattt 1057741 atacgctgca gcttgagaat gcgattcttg ccggtttttc aatgggcggc gcaattgcaa 1057801 tccgttatat ggcaaggcat gaaggagccg atgttgataa gctgatttta ctgtctgcgg 1057861 cggcccccgc gtttacaaaa cgcccgggtt atccgtacgg gatgaggaag caggatattg 1057921 acgatatgat tgaattgttc aaagctgatc ggcccaaaac actggctgat ttagggaaac 1057981 agttttttga gaaaaaagtg tctccagagc ttaggcagtg gtttctcaat ctgatgctgg 1058041 aggcttcctc ctacgggacg atccactcgg gcatcgcatt aagagacgaa gatctcagaa 1058101 aggaacttgc tgcaatcaag gtgccgacgc tgatcctgca cgggagaaag gatagaattg 1058161 cgccgtttga ttttgcgaaa gaattgaagc gcggcatcaa acagtcggaa ttggttccgt 1058221 ttgcaaacag cgggcacgga gcattttatg aggaaaaaga gaagatcaac agtttgattg 1058281 cgcagttctc caactcataa gaaaaaaccc gacattgatc gggtttttta tataattcct 1058341 ctgttttgca gtgcgttaat gatgagatca gctccatcgg aaatagaggt ctggtcagac 1058401 tcaatgatga aatcgggtga aagcggcgct tcatacggag aatcgatccc ggtgaaatgt 1058461 ttgatctctc cgtttcgcgc ttttttataa agcccttttg gatcgcgctg ttcacaaaca 1058521 tgcagcgggc acttcacata aatttcgaag aactcacctt taggaaagag cgctctaacc 1058581 atgtcccgat cctctctgaa tggagaaata aaagccgtta aaatcatttg cccgctgtcg 1058641 acaaacagct tcgccacttc tccgatccgg cggatgtttt caatcctgtc accagtctga 1058701 aatccaagat ctttgtttaa gccgtggcgg atattatcac cgtcaagcac gtagctctga 1058761 atgcccttgc ggtaaagctt ttcatcgaca gcattggcca gcaccgattt tccggagccg 1058821 gacaaacctg taaaccaaag gacgcagctt ttgtgtccgt ttaaggactg tctgtcagac 1058881 tttgagatgg cagcgggatg ccaaatgatg ttcggattgt gtgtcattgc aattccccgc 1058941 tgttttgctt gatggcaaca ggctgttggt gaagtccctt gatcagcacg gctgcgacct 1059001 caggccggct gaattcttta ggcggctttt tgccttggcg gagaagctct ctcacttttg 1059061 tgcctgataa gtggatgtgg tctctcgggc tgtgcggaca tgttttggag gtgcccatgt 1059121 ttccgcattt tcggcaataa aagctgtgct caaaaaacag cggcttgatg cccagctctt 1059181 cctctgtgaa tgattgaaaa atattttggg cgtcgtatgt tccatagtag ctgccgacac 1059241 ccgcgtgatc acggcctaca ataaaatggg tacagccgta attttttcgg acgagcgcat 1059301 ggaaaatcgc ttcccgcgga cctgcataac gcatggcggc agggaaaacc gataacatga 1059361 cacgatcctt tggataatag tgattaagca aagcctggta gctctccatt ctgatatcgc 1059421 tggggatatc gtctgacttt gtttctccga caagtgggtg aagcagcaga ccgtcgaccg 1059481 tttctaacgc tgttttttga atgtattcat gcgctctgtg aacagggttc ctggtttgaa 1059541 agccgacaat cgtcttccag ccgagttttt gaaaggccgc tcttgtttca gcgggcgttg 1059601 cataaaactg ttcgaaagat ttgtcaggca ggctgctgac cgtgataggc cctccgatat 1059661 agtaatccgg gcgcgccagc aattttttta cgcctgggtg ggcaggatcg tttgttttaa 1059721 aaacagacag tgcttcttgt gttttatcag gctggtatat atcggtgact gtgatcatgc 1059781 cgtaggtaac accgtctttc acaagcttga cgtgatctcc ggcagacagc tgtcttgctg 1059841 ttttttctcc gacaggcagc gtaatcggca ggctccacgg caagccgttt gccagcctca 1059901 tctctttcac aacggaatga taatcttttt ctcccaaaaa acctgttaac gggctgtagc 1059961 cgccgatcgc aataagctcc agatcactca gtgcaagctg atccagctct gcttggcacg 1060021 cgcacccttc aaaatggcat gcgggatcac agcggttgat taatacccct ccgtggggtt 1060081 cgtttccatt caacgtgttc aacctccatt tatacgtttc cttgttttct tttctgcact 1060141 taatgaaagt ttgacatcag cgccttaaca tcatttcgat tctcacatca agaacctgcc 1060201 atccgctatt cttgatgcag gccgcattct gttttctccc gtccggccca tcttccagcc 1060261 ctctcatcgt tcgggtccgg ggaaggcagt gtacacattt cacagcctat gctcggataa 1060321 tgttgatcgt gcagtttgtt ataaggcaaa ttgtgcaggc ggatgtacgt ccaaacgtca 1060381 tcccatgtcc agtggataag cgggcaaatt ttgatgagct caaacttctg gtccaggttt 1060441 acgtattgaa tatgctttct cgttggtgac tgatcccggc gcagtcctga aatccaagct 1060501 gtcatgccgg acaggtgctt tttgagcggt tcgattttcc gcaattggca gcagaggttc 1060561 gggttatgct tccacagctc tccgccgtac ttcgtcccct gttctgttaa gctcagctcg 1060621 ggttcgagca tctggattgc aaatcccgga tatcgttctt tgacggtctc gatcagctca 1060681 tatgtttcct gaaaatgaag cccggtatcc aaaaagatga tgtgtgcgtt tttgttgatt 1060741 tttgatatta agtcgagaag caccattcct tctgcgccaa agctgcaggc gtacacaatc 1060801 ttttctccgt acgttcggta agcccatttc aacacatcga gctcatcgat caattgatcc 1060861 gttatctgtt tggacagcat gtcgttccaa gtgtcatatg tgatggtttc gttcaatgtt 1060921 ttccccccgt ttgcatctgc tttttttatc tattgatcga gttataggca gactattcat 1060981 tttttgcata aaggttcagg ttttaggtgc cgcgcccgcc taaaatgagg tgcggaacca 1061041 ttaagagccc ggctgaatat gctttttagc aaaatggttt tatgcccaag gagaggtagt 1061101 atgccgattg ccatttatca ggggcatcat cattcgcttg ccccggcgga cattaacatc 1061161 gtcattgatg tcatcagagc ctttacggtc gcccattatg cgtttatcgg cggggcgaaa 1061221 gagattttgt tggtccggac agctgatgaa gcctttgcgc tgaaagacac ctatccggat 1061281 tatgttttga cgggagagga aaagggggtc ggtatcagcg gatttgattt agataattct 1061341 ccaaaacgta tggctgggca gaatatgacg gataaaagcc tgatccagaa aacaacaaac 1061401 ggcgtcacag cagcattggg ggcgctgaac gcaaagcatc tgttcgtaac tggattttcc 1061461 aatgccaaaa caacggcaca gcatgtgaaa aagctcgtcg caaacgattg tgtcataaac 1061521 atagtggctt cccatccatc cggtgatgac gatatggcat gtgcggagta tatcaaaggc 1061581 atcattgaag ggacaaatgt ggtaacggct gcggaggcga ttgaaagaat aaaaggctct 1061641 tctgttgcgg agaagttttt tgactgccgc cagccattgt ttgattcgga agacatcgtt 1061701 tactgtacaa aagaactgac gggcgatttc gtgatgaaag tgaaacaaga tggagaagtt 1061761 ccaacgatag agagggtcat aatatgaatg atttttcact agaattgcca gtgagaacaa 1061821 acaagccgag agaaaccggg cagtccattt taattgataa cggctatccc ttgcaatttt 1061881 tcaaagatgc gatagccgga gcgtccgact atattgattt tgtgaaattc ggctggggca 1061941 catcattact tacgaaagat cttgaagaaa aaatcagcac actgaaagaa catgacatta 1062001 catttttctt tggcggcaca ctgtttgaaa agtacgtaag ccagaaaaaa gtgaatgaat 1062061 ttcatcggta ctgcacctat ttcggctgtg aatatattga gatttcaaac ggtacgctcc 1062121 cgatgacaaa taaagagaaa gcggcttaca ttgccgattt ttctgatgaa tttcttgtgc 1062181 tcagtgaggt gggcagcaag gatgcggaat tagcaagccg gcaaagctct gaggaatggc 1062241 ttgaatatat cgttgaggat atggaagcgg gcgcggaaaa agtgattaca gaagccagag 1062301 aaagcggaac gggagggatc tgttccagca gcggcgatgt caggtttcaa attgttgacg 1062361 acatcatttc ctcggatatt gatatcaaca ggctgatttt tgaagcgcct aacaaaacgc 1062421 ttcagcaagg gtttattcaa aaaatcgggc cgaatgtgaa tcttgccaat attccatttc 1062481 atgatgccat cgcgttggaa acgctgcgtt tagggctaag atccgatacc ttttttctgt 1062541 aaaatagcgg ctgcggggct ctcgtcgtga agagagcctc tgcctattat tttttatggc 1062601 ggtacatagg cgtgagatag ggaagtgagg tcaggcggat gttgtagatg aagtcgatga 1062661 ctcttgtcga tatcacctgg catatgaggg cttgaatgac gatgccccag tcaataatag 1062721 acgcggtgac cataaaaatg atgcaattca tgatgagcag gatcgttcca ggattcccgc 1062781 cgcggtagat agaaatcatc agagcaaggg ctccgaatcc tccgttcgaa attttatatt 1062841 tgtataaaag tccgattccg agtcccaata acactgcgcc gcttgccaga tcaagccaca 1062901 ggttagatgt gatatcagga aaaactgcat caaagatcaa taccgagaca gaggtgacgg 1062961 tgatagaagc gagggtgccg gtgaatgttc tcatctccag ccattttaaa gcggtaaaaa 1063021 gcattgatac attcacagcc cacactgaaa atccgtgggg gatttgaaac agataatgca 1063081 atagcaccgc aatacctgct gcaccgcctg tcggaatatc atgcggaaat aaaaacaagg 1063141 acatgccgag tccttgtagt acgccgccta cgacaatcat aaacgtaagt tttgctttca 1063201 tcagcagttc agccattaag tcatttgctc ctttatgaaa agacttgtcc gctgttttca 1063261 ttttatgagg ctgtccatta tttatgtctc aaaataaaga aatggcccag cttaataggc 1063321 tgagccatcc cacttgtagc gattgacgat ctccatattg atctctgtgc caatgccttt 1063381 tcctttcggg atgtggacca ttccttttga aggctgcagg ctgacgagat ctgtaaaagg 1063441 attctccatg acgtcccact cgatcggttc aatgtgatcg ttcttcattt tagaccatgg 1063501 gggcagacag gcttgtgcaa ataaagcata gagccgtgag agcgatccgt catatgcatg 1063561 ggcggatgct ctgacgccga aataacgcgc gagctggagg cagtcccgaa actcatcaat 1063621 tccgttgaca tgcatgacat cgggctgaat gatatccaaa cagcgctgtg aaaggagagg 1063681 cacatattgc gccgggcctt tcatgttttc tccgccggca acaggaacag acaaacggct 1063741 tcgaagcata gcgtaatcct gcggctgatc aaagggcaaa ggctcctcaa gccagccaat 1063801 gttcgtccat tcggagaaat agcgctccca tttaaaagcc gcagcggcat cgtagctttg 1063861 gtttgcgtcc agaatcatcg taatggagct gcctgctgta tgctgcagcg cattgatgtg 1063921 ccggacatcc tccttgaatg aagtcccgcc aattttgact ttgatttgct caaaaccttt 1063981 tttcaactgg gcttcaacat tggagactga gcggctgatc cattgcgggg agtctgagta 1064041 cgattgaaaa gacgcgtaca caggaatctc ctctctgtat cgcccgcccc ataattcgca 1064101 aaccgaacaa tccgcagctt tggctgcaat ctctgtcagc gccatgctta cagcggaggc 1064161 cgcccgctgg tgccattttt gaatcgtgcg cactaatgac aggcggctgc cagcctgttt 1064221 tcctaataga aatgggatga tccgcttcgt aaaaccgaca tggagagcag ggagccaatc 1064281 aacgcattct ccccagccgt ctatcccgct ttcggtgata atcctgatga gataacaagt 1064341 ccgatatcgt ttaaacccat tggcatctcc gtatggcttt tctaatcgat gaaatagcgg 1064401 aaaggtttca atccgtacaa ttttcacact gggtgctacc tttcctcagc gggctggagc 1064461 cgattgccag ccattttagg gtcttctttt tcttttgttt cttcattgtt ttgcttcaca 1064521 tggatgagca tcatcacaag aatcccgaca acgagagtca atcccgcgat gcttaaaaac 1064581 atgccgggtc tggaccattg catcaggcgg ccgaaaatcg gaggaccgat cgctacccct 1064641 aagaaacgta cagagccgta cagcgaggtg acaaatcccc gtctttcttt gccgacagcc 1064701 ccggtaatga aactgttcac acaaggaagg acaagacctg agcctatact gctcagtaca 1064761 agaacactga taaaaaggac aagattttca atgaatgaca gtgccgcgta ggatacggtc 1064821 atgaacgcca atccaagtac gatcagcttt ttcattaacg attgcttttg cccgattttg 1064881 cttcctgttg tataggacgt cacacacata accaaaagcg ggatcgctaa aattaagcct 1064941 tttttcacgc cgtcggtgtc gtatgttttt tcaagaacat ctgagagata aaacaggatg 1065001 ccgaataaag taaacaaaca ggtcgcaccg gctaaataag cggtaaacag ccatctgcct 1065061 tcatgtttaa agacacttaa cagccctttt gcatattgtc cgattggtgg cggttctttt 1065121 tcctttttct tttctttaat aaaaatccaa gtcagtacga tcgaaatgat acaaaacaca 1065181 ggaaaggcaa aaaacgcgcc ataccagaca agcagggcga tcagcgagcc aatgatcggc 1065241 gatagcactt tccccatgcc gtttgaagct tcaacaaggc cgagcacctt gctctcctgg 1065301 gcgcctttaa acagatctcc cgtcagtgcc atggcaattg ggccggttcc ggctgccccg 1065361 attccctgta acgctcgtcc tgccatgacc caaggatagg cattgtcaaa aaaacctgcc 1065421 gcaaacccgg ctaacaaacc gccggcacca tacaaaatta agcagggaat aatgatgact 1065481 ttccttgaga atcggtctgc gagataaccg acaatcggaa tcgcaaatgc tgcaatcaag 1065541 gaaaatactg tgatcacgag actgacttga aattgtgata aatgaagttc agatttcatt 1065601 tttggcaaaa tcggaataag catcgagttt cctagggtta atattaaagg gattgaaccg 1065661 attgccacaa tcgtcattcc gttattttgt tttgatgatt ccatctcaga gcacactcct 1065721 tttcttctgc ttagaatgtc cctgatggct tcgtttattc agcgatcaga cagcaaaaaa 1065781 ccgaacagaa gatacctgtt cgggaaaaaa gagggttaac cgagagcctg tgaaatcaaa 1065841 gcatataagt gtccattttg aataggcgct tttttctgat agaacaaaat cggaggttca 1065901 tcatctttat gaaatcccat ttctatcagg ctgtcatgca gagacgtgtg ttcactcggt 1065961 atatcgattc gcatcggccc ttgtttgccg gccgccagcc ttgtaattat ctgtgctgca 1066021 acatctgatg atggagcgat gatagggccg aatttcaaat tggccggtgt ctgtacagaa 1066081 agtccgtagc caatgagctg tccgtcctga tttctggcga tgatacattc gcatgaagca 1066141 gaaataagct gctgcaaaag gtttgatcga tctccgccaa aggcagccag atccgccgcg 1066201 gttaagtcgt gaaagtcttg ttctctaaag gatgtcagtt cagcatcaag cttttttgta 1066261 taaggttgaa aactgtgaca gctgtacttt cgcactgaac ctgccgtatg aaaacctgct 1066321 ttttcataaa gcggcaaacc ttcttttgtg gcgcaaagcc tgatggcggt gttttcatcc 1066381 gtttgggtaa tacaggcgtt taccatacgc cggccaagac cgagccgttg atattccttg 1066441 tcaacgataa caaggccgat agaagtaaga cggccaaaca aaaacaagcc gatgcaggaa 1066501 ataatatcac cgctgacatt ttgataaccg aaaaagcgtc cctgctgaac aagcagtttc 1066561 agctcttgtt cgccataatc cggccacccg gcttgcccgc aaagccgcaa taagccggaa 1066621 acgtgttctt catgaagctt aatcagttca tctactacgt ccataagatc acctgcttgt 1066681 tctaagtgtt ttgtacatga caatatgatt gccaatgccg ggaatgtcaa atggttcgcc 1066741 aagttccttc cagccaagct tggcatagta gcccttgaca tggtgtcttg cgttgcacca 1066801 taccgcctga acgccgctct ccgccagttt gtgctccgcg tgtttgatca gcgtgcttcc 1066861 agctttttga tcgcgatatc cctcgagcgt tgccatgcct ctcagccgat acgcagaggc 1066921 ttccgttaat aaaggctgac tttgcgggga aaaagaagcg atgctgatca gcgttccatc 1066981 ataaaacacg ccgagatgaa aggagccttc tgcgtgatcc tctttatatt tgcattgttc 1067041 gatggattga tggggacgca gaatgcgatg ccggatttca tatgtatctt ccacggaaat 1067101 ggttttgact tcgagcataa tgttcctcct catgattgtt tttctatatc gtaacacgaa 1067161 tctcgttgaa aaagactgcc cgattcgatc aggcagtctt ttggaaatta atgcaaaaag 1067221 atattttggc gctgctcatc tttttgctga atatatgatg tgagctcagc ggttaagtca 1067281 gatctgagga aaggcgttat caagtagatg ccgttaaaca gctcgcatgc cgtatccagc 1067341 agggagcgtg caattgcaag gccttccgcc ttttgctttt ctttatcttc accggcatgg 1067401 gccatttttt cgcgaatcgt atcagacagc ttaatgccgg gaatttcatt atggatgaat 1067461 tcggcattcc ggctgcttgt cagcggcatg atgccgatat agatcggcgt cttcagatgt 1067521 tttgtttcgt tatggatatc gacaagctgc tgctcggaat agacaggctg agaaacaaaa 1067581 taatctgcgc cgcaatctat ttttttctca agccgtttta ccgctttatc cagatggcgg 1067641 acgttaggat taaatgcggc ggcaactgag aaattcgttt tcttgccgag cggttttcca 1067701 gacagagaca gaccttcatt gaattgtttg atcagcctga ttaaatcaaa agatgttaaa 1067761 tcatatacag acgtcgcccc aggaaaatcc ccgattttag aagggtcacc tgtaatagca 1067821 agcacgtcat tcagccctaa cgtatcaagg cccattaaat gtgactgtaa gccgataatg 1067881 ttacggtcac ggcacgtaat atggacaagg gaacgcatat cgagctgctg cttgacaagg 1067941 gcgccgcagg caacattgct gatccgcggg gtcgccaaag aattgtcggc gagtgtcagg 1068001 gcatcgattc ccgcttcttt taattcagca gcagcggaca gaaatttgtc aaagcttagt 1068061 tttttcggcg ggtccagctc tacgataata gagcgttttt tcgctgcgat ctcatccagg 1068121 ccgggctcgg ttcgctcgtg atgaacagaa atgaattctt tcgcccgggt tttgacttct 1068181 ttttccgtaa tcggagccag cccgccaacc gcttccgcca tcgccctgat gtgattcggc 1068241 gttgtgccgc agcagccgcc gataatccgc gcaccttgct tacggaattc tgacgcgctg 1068301 ttttgaaaat acgtgtcgtc tgtttcatag acgagccgtc cctcttcaag cgaaggaaga 1068361 ctgctgttcg gataaacgga taagaatacg tcatcaaaaa tcggcacttc gcttagcgct 1068421 tcaatcatgt gataagggcc gaggcggcag ttaatgccga caatatcagc tccgagatcc 1068481 gcaatcgagc gcaatgcgtc agaaagcggc gttccgtcct gcaatacgcc ttgctcgtgc 1068541 atggagacat tgagcataat cggaagatca gtctctttgc gcgcgatttt cagcacttca 1068601 cgggcttctt ccaaatcata atatgtttct aacagcaagc catccggctc ttcatgcagc 1068661 agcagataca gctgctcgcg gaagctgcgc ttaatttcgt caagactgta tgcgttttta 1068721 ttaaatgtgc gtatgccgcc catcgttcca agcacgtatg catcgcctgc tgaagcccgc 1068781 gcgatcttta cggcctcctg attcattttt ttgatgtcat cctcaagccc gtgtctggat 1068841 aatttaatat agttggctcc gtacgtattc gtttgaataa tgttggctcc cgcttcaacg 1068901 tacgctttat gtatgcgctg aatttcctcc ggctttgaaa tattgagctc ctcaaaacac 1068961 ctgtcaatgc cataggagta gaggagcgtc cccatggcgc cgtcaccgat taacacctgt 1069021 ctttgcaaat cttctaaaag tcccattgtc tgcctccttt attcacatca gcaaggaaaa 1069081 aagagaaata aaaaaagtcc tcttaagaag aagactttgt cagtgatttt gtctcttctt 1069141 atcttccaag ctgttcgagc ttgctggatt tagcaccttg gtcatggctg atcgccatta 1069201 caccggttgc tgaagcttcg tcgggccagt ccctctgctt ctcttgataa gaacggatat 1069261 gaaattttcg tgtcaggaag tgccaaaaga tatctggcgt ttttcccttt ctccaaattt 1069321 accgaaaata aagacaataa tcaataggaa tcagaaaatt tatctgaaat ttataaattg 1069381 aacgtcaatt ggcagatctg ctccccgtac agctgagata atctgctgca ggtcatcttt 1069441 gttttttccg gtgacacgca cttgatcatc ctgcacctga gactttactt tcagtccgga 1069501 gtttttgatg atcgtattga ttttttttgc gttgtccttg tcaatgcctt gaacaagctt 1069561 tgcacgctgg cgcaccgttc cgcctgacgc gttttcaacc ttgccgtaat caatgttttt 1069621 tgtcggtacg tttcgtttaa tcaatttgct gaccagcaca tctttcagct ggcttaattt 1069681 gaattcgtca tcggaaacga ggaccagctc ctctttatct aaagaaatgt cgcttttgct 1069741 gcctttaaag tcatatcggg tactgatttc cttcagtgcg atttggattg cgttttgcac 1069801 ttcaggcaat tccaccttgg atacaatatc aaatgaactt tcttttgcca tatgaaaacc 1069861 tccataacat ttaacttatg tgttgattat agtagaataa agagaaactt ccaacagaac 1069921 aaagaatcaa tttgtgatga ttggaaaaaa tgttaacaaa atccgcagag aataagcgga 1069981 acaggaagga cgatagcatg agaccagggc agcaattaac cttgagtata gatcaccaaa 1070041 ccgacttcgg ttacttttta accgatgggg aagatacgat tctcttacat aacagtgaaa 1070101 tgactgagga tatcgaggac agagacgaag tagaagtctt tatatacgta gaccagcagg 1070161 aaaggcttgc ggccacgatg aaaattccga tcatcagcgc ggatgaatat ggctgggttg 1070221 aagtggtgga taaagtggaa gatatgggcg ttttcgttga tgtcggttta tcgaaggacg 1070281 cactagtcgc aactgagcat ttgccgccgt acgaagatgt ctggccgcaa aaaggggaca 1070341 aactttactg tatgctgaag gtgacgaacc gggggcgcat gtttgcgaaa ccagcgccgg 1070401 aagatatcat cagcgaactg tttaccgacg cttcagaaga tctgatgaat aaagagctga 1070461 caggtacggt gtacaggctg atcgcatcgg gttcattcgt gatcacggat gacggtatcc 1070521 gctgttttat tcacccgtca gaaagaaaag aggagccaag actgggttca agagtcacag 1070581 gccgggtgat tcaagtgaaa gaagacggtt cagtcaactt gtcgctgctt ccgagaaaac 1070641 aggatgcaat gtcagttgat gctgagtgca ttctaacgta tatgagaatg agaaacggtg 1070701 ccatgccgta cagtgacaaa agccagcctg acgatatcag agaacgtttt aatatgagca 1070761 aagccgcctt taaacgcgcg ctgggccatt tgatgaaaaa cggaaaagtg tatcaggaaa 1070821 atggatggac atacgagaaa aaatagcatg aaaacggctc gcctgcagca gactgcggag 1070881 cgagccgttt ttttatgtct agtttaattc atcaaccagc ggccaactat atcatattaa 1070941 tttgccaaaa tcgtgttcaa atatttgttt taagggaaaa cataataaag aagaaagagc 1071001 ggaggaacat gccatggtac tagatcaaac aaaaaaatta ctcatcgtca tcatcggcgc 1071061 tttactcaat gctgccgggc tgaacttatt tttgatacct gcagatgtat atgccagcgg 1071121 atttacaggt gttgcccagc ttttatcaag cgtcgttgat caatatgccc ccttttacat 1071181 atcgacggga acgctcttgt tcctcttaaa cattccggtc ggtattttag gatggctgaa 1071241 ggtcggcaaa tcgtttacag tgtacagcat tttaagtgtc gcactcacta ctctgtttat 1071301 ggggatcctg ccggaaacaa gcctgtcaca tgacattttg ctgaacgcgg tgttcggcgg 1071361 cgtcatttcc gcagtcggta tcggcttaac attaaaatac ggagcttcga caggcgggct 1071421 tgatatcgtc gccatggtac ttgcaaagtg gaaggataaa cccgtcggca cgtatttctt 1071481 cattctgaac gggattatca tcttgacggc aggattattg caaggttggg agaaagcatt 1071541 atataccctg gttacactat atgtgacaac gagggtgatc gacgccattc acactcgcca 1071601 catgaagctt acggcaatga ttgtgacgaa aaaagcggac gaaatcaagg aagccattta 1071661 cggaaaaatg gtgcgcggca tcacaactgt tccggcaaaa ggagcattta cgaacgaaca 1071721 gaaagaaatg atgattatcg tcatcacgag gtatgaactg tacgatttag aaaagatcgt 1071781 caaagaagtt gatccaaaag catttacgaa catcgttcaa acgacaggga tttttggttt 1071841 ctttagaaaa gactgacgaa agcaggtgga agtcgtgaaa cggctgcttg tgatgctcct 1071901 ccccgtgctg cttttgatag gctgcgggaa agatgagcag acagaacccg ataaggaggt 1071961 atcaggcgga atggagaatc aagaggttgt tttatctatt gacgcaattc aggagcctga 1072021 acaaatcaag tttaacatgt cgctgaagaa ccaaagcgaa cgtgctattg agtttcaatt 1072081 cagcacaggg caaaaatttg aacttgtcgt gtatgattct gagcacaaag aaagataccg 1072141 ttattcgaaa gaaaaaatgt ttacgcaggc ttttcaaaac ctgacgcttg aatctggaga 1072201 aacatatgat ttctctgatg tgtggaagga agtccctgag cccggaacct atgaggtaaa 1072261 ggtgacattt aagggcaggg cggaaaatct caagcaggtt caggctgttc agcagtttga 1072321 agtcaaataa gaggctatgg cgagtcgcca tagccttttt ttattgcagt ttgtccagct 1072381 gattttgaaa ttgatgcaac tgttgacgtt ccgcatctgt cgaattggca tacgcagaag 1072441 atacagcatt tttggctctc agaatcgctt gctcctgatc gccttcctca aagccgtttg 1072501 tcaccatgac cgcctgttga acaaatgatt ttgcctgctg aaacagttca tttctcattt 1072561 aatattcata ctgcctttca gccgagtctc gtgccgcggc atgctggtga gcttcttcta 1072621 aagtagaccg atatggaaat cttgcggcgt gtagcccgat ggagtcttta ccctgctgaa 1072681 taaaccttct ggatttgctt cgtttaccca ttttgagact gcccccttcc atactttgac 1072741 gagatgagtc gtcttcaata gtatggtggg gtaaagtaag gtttatgagt gggaaaaatt 1072801 aatacggacc ttctttaaag tgagaaatat tctttcaaaa accttgccac gccgtcctct 1072861 tcatttgtgg ccgtagttcg gttggcaatc tgcttgaccg cgtcaattcc atttcccatt 1072921 gcaacgccgc agcctgcaaa ttcaagcatt tccaaatcgt tatcctcatc tccaaaagca 1072981 atgatccgct ccctcggcac gccgtaataa tcgctgattt tctgcaggcc gaccgcttta 1073041 ttcatgccgc ttttgataat ttcaatgaca tgccaaggag cggcccatct tctatggtcg 1073101 atcacctcgg catgcacatc cgataaatat gagcgtattg ccggcacatc ctcttccttt 1073161 gcatgtatga gtacggacgt cacatcttca ccgagatttt cccgcaagtc tccgaccgtt 1073221 acatttgttg tgttcatgtt aaaggcatct atcaggtgct catcatggta atgaaagtat 1073281 acgtcgtcaa tcacttcagc aagcacgtta tgtacgttgt agctctcgct gatatccacg 1073341 agctgtttga caacatcaag cggcagtgac gtatgatacc gtccccagct gtcgtcttgc 1073401 ggatgatgga caaatgctcc gttaaaattg acaattggcg ttgtcagctc catctgctgg 1073461 tagtacatgg aacttgaacg atacggacgg cctgttgaga tgcagacata atgcccgtca 1073521 tcttttaggc gctgtatcgt atgaagggtg ttttcagata tggttttatc atcctttaat 1073581 aatgttccat ctaaatctaa tgcgattaaa tagggttttg tctccatgaa aagctccttt 1073641 aaccttagat tttgcttgtt ttgccttact tacagtgtag ctttttacca tctttattgt 1073701 ctacatgtta cacttatgat tatggttatc ctaaggaggg gcacattgtg atacaaattg 1073761 agaatcaaac cgtttccggt attccgtttt tacatattgt aaaggaagag aacaggcacc 1073821 gcgctgttcc tctcgtgatc tttatacatg gttttacaag cgcgaaggaa cacaaccttc 1073881 atattgctta tctgcttgcg gagaagggtt ttagagccgt tctgccggag gctttgcacc 1073941 atggggaacg gggagaagaa atggctgttg aagagctggc ggggcatttt tgggatatcg 1074001 tcctcaacga gattgaagag atcggcgtac ttaaaaacca ttttgaaaaa gagggcctga 1074061 tagacggcgg ccgcatcggt ctcgcaggca cgtcaatggg cggcatcaca acgcttggcg 1074121 ctttgactgc atatgattgg ataaaagccg gcgtcagcct gatgggaagc ccgaattacg 1074181 tggagctgtt tcagcagcag attgaccata ttcaatctca gggcattgaa atcgatgtgc 1074241 cggaagagaa ggtacagcag ctgatgaaac gtctcgagtt gcgggatctc agccttcagc 1074301 cggagaaact gcaacagcgc ccgcttttat tttggcacgg cgcaaaagat aaagttgtgc 1074361 cttacgcgcc gacccggaaa ttttatgaca cgattaaatc ccattacagc gagcagccgg 1074421 aacgcctgca atttatcgga gatgaaaacg ctgaccataa agtcccgcgg gcagctgtgt 1074481 taaaaacgat tgaatggttt gaaacgtact tataaagcac taagttatta acaagagctg 1074541 aatttacgtt atactgtaga aaaaaggagt gagggaacgt ggaagaagca ttaaaagaaa 1074601 acatcatggg cgccctggaa caggttgtcg atcctgagct tggcgttgat atcgtgaacc 1074661 tcggcttggt atatgacgtt gatatggatg aagatggctt gacgcacatc accatgacgc 1074721 taacatcaat gggatgccct ttagcgccga ttatcgtgga tgaggtgaaa aaagcattag 1074781 cggaccttcc tgaagtgaaa gacacagagg ttcacattgt atggaatccg ccttggacta 1074841 gggataaaat gtccagatac gcaaaaattg cgcttggcat tcaataaaac aaaaaaggac 1074901 agcctgacat gtgaggctgt ccttttttac agctgaaagg agtgaaagga aatgatgtac 1074961 ctgctggcag ttttatgccc gccgcttgct gttttgtttt cgggaaaacc gtttcaggcc 1075021 ttgctgaatc tcatattgac ctgtatcttt tggctgccgg gcgcgattca cgcctgcttt 1075081 atcgtcgccg accgccgtgc cgaaaaacgg gcaagaagat aatttggaaa aatgaggacg 1075141 cagtcatggt ataatggtca taaaaacagc agggagagca ctatgaaaaa gaaattgctt 1075201 gcattcgcgc tttgtactgg cgcgtatgcg gccctgtttg cgtactctgt gaactcagag 1075261 caaaaaacag ccacaagcga gatgacggat gtcagccgcc tgatgcctgt aaaaataaag 1075321 cagacagtga aagggcagga agaggaaatg ctcattgaca cagtcaaaga ggcaaatcga 1075381 aaaaacataa aaatttcaat cgccggggcc cagcactcca tgggcggcca tacatattat 1075441 gaggacggca tcgttctcga catgacgggc tacaacaaaa tcctgtcact cgatcaagag 1075501 aagaaaacca tcagggtgca aagcggtgca acgtggaatg atatccagaa atacgtgaat 1075561 ccatacggac tcgcggtaaa agtcatgcag tcacaaaaca tttttacaat cggcggatct 1075621 ctcagcgcaa atgcacacgg acgtgatatt cgctacggct cgctaattga tacagtcaaa 1075681 tcattccggc ttttaaaagc tgacgggatg attatcactg tcactccaaa agatgatttg 1075741 tttacggcgg tcatcggagg gtacggcctt tttggcgtga ttcttgatgt aacgcttgag 1075801 ctgacagatg atgagctgta tgtcatgaag acagaaaaaa tgaattacag cacatactca 1075861 gactattttt caaagcatgt aaaaggaaat ccagatgtcc gaatgcatct ggcgcgaatt 1075921 tcaacagcga aaaaaggatt tctgaaagac atgtatgtca cgaattacgt attggctaat 1075981 catcaggatc agctgtcctc atacagcgaa cttaaagaag acgagtatac gggagccaca 1076041 aagtttgcac tcggcttgtc aagacggtat gaatggggga ggaattggct gtgggacaca 1076101 cagcaatcct atttcctgag ccagaacggc acagagattt cacgcaataa cgtcatgcgg 1076161 tccgaatcaa agtttcttga gtatgaaaac aatgacaaca cagatgtttt gcaagaatac 1076221 tttgtgcccg tgaaggagta tgggtcctat attgatgacc tgagacaaac gctgtcggac 1076281 gaagatctga acctgctgaa cattacgatc cgctacgtgc agaaaaatga aaaggccgac 1076341 ctttcctatg cgaaggacga tatgttttcg ctcgtactat taataaacga gggcttttca 1076401 aaagaagacc aggcagatac cgcccgaatc atcaggcgca tgacagacgt tgccatcaag 1076461 cacggcggca gctattatct gccttatatg acctaccaga caaaagcgca aatgagacag 1076521 gcatatccga aaagtgaagc gttttttcag aaaaaacgaa cctatgaccc ggatgagcgc 1076581 tttatgaatt acttttatca gaggtataaa taatggggaa aaacaaatta aaatggctga 1076641 cattatcaca aagcagcgtg tttttcgcaa gcagcttaat ctttccgttt tatattctgt 1076701 ttgtgaaaaa tatcggctca agctacacac agttcggttt ttcctacgga ttgttcgggt 1076761 tgagcggagc gcttatttac ccgctcctcg gacggctgtc tgaaaggttt gacagccgtt 1076821 attttctgct tctgaactcg tgggggatgg ctgttctgct tttatatgtc ccgcatatcg 1076881 gaagcgtcgt tcaagtgtat atcgtccaag tgctgttagg gctctttgga gcgatgcaaa 1076941 agcatggaga aaaagtgctg atcgctaatt ttacagacag tggagagcgt ggaaagaaga 1077001 tcgggaatta ccatttttgg acagctgtct tttcagcagc agccattatg ctcgggggct 1077061 ttctcgctga ctttttcaca gtgcaaatga ttttttatgc aagctctatt ctatattttt 1077121 tgagtggatt gatgatgatg aaaacaggct gacgcggtca gcctgttttt ttatgcggct 1077181 gaaatgcggc accgcatcaa cgtttttgtg ctggagtcgt gctgattttt tttgagcgga 1077241 attcccattg aacagaaaat ttataaatga ataaaaatat taaatatacg attgaattaa 1077301 tttttattca tgttataatg ttaaataatt tcacaaagac caagagggtg aacttgtttt 1077361 gaaaatagga attgtaggtg ctacaggata tggaggcacc gaacttgtca ggattctttc 1077421 gcatcatcct catgcagagg aatgcatact ttattcatcc agcggagaag ggaatgtcta 1077481 tagcgagggt tatcctcatc ttaccggctt agcggatcag cagctgaagc cgattgatat 1077541 gaatacgatc aaacacgaaa tagatatcat gtttctcgct gcgccgcccg gagtatcaag 1077601 tgaattgact ccaaagctgg cagacgcggg aattacggtt attgatctgt caggtgatct 1077661 gaggataaaa gaaccggctg aatatgaaaa atggtataaa cggacagcgg caccgaaggc 1077721 ggtgattcaa gaggcggtat acggtctggc agaactgaat caactgcaaa ttcaacaggc 1077781 gaaactcatt gccaatccag gctgttttcc aacagctgtt ttgcttggcc tcgcgccatt 1077841 ggctcaaaag aaactgctcg atgaatcttt cgttatcgtt gacgcgaaga ccggtgtttc 1077901 cggagcggga agaaaagcat ccatgggaac tcatttttct gagctgaacg acaattttaa 1077961 aatttataaa gtcaatgaac atcagcacac gccggaaatt gagcaggcgc tgaatgaatg 1078021 gcagccaggt ctcgggccca ttacattttc ggctcacttg gttccgatga caaggggcat 1078081 catggcgacg atgtatacca gattaacctg tgacctaacc gcagatgacc tgcatgattt 1078141 atattcggaa ttttaccaag attcatattt tgtgagagtg aggccaaaag gtcagtaccc 1078201 gcaaacgaaa gaagtgtacg gcagcaattt ctgtgatatc gccgtgaccc tcgatgagag 1078261 aacgaacaga gtcacgatcg tctcggtaat cgataattta atgaagggtg ccgccggtca 1078321 ggcagtgcaa aactttaatt tgatgaatgg ctggaatgaa gaaactggac tcaccatcac 1078381 gccaatttat ccatagaacg ggagagaatc gaaccatgat tcagttaagt gaagatcaaa 1078441 ttgtaaaagt aacaggtgat gtatcctcgc caaaagggtt tcaggcaaag ggtgtgcatt 1078501 gcggactgcg ctactcgaaa aaagacctcg gcgtcattat cagcgagaca ccggccgtga 1078561 gtgcagcagt ttatacccaa agccactttc aggctgctcc gatcaaagtg acacaagaca 1078621 gcttaaagca cggaccgaca ctgaaagccg tcatcgtcaa cagcgccatt gccaacgcct 1078681 gcacgggaga acagggctta aaggacgcat acacaatgcg ggagagcttt gcttcacagc 1078741 ttggcattga gccggagctt gtcgctgttt catcaacggg tgtcatcggc gagcatttag 1078801 acatggaaaa aatccacgcg gggatcgaac tgctgaaaga aacacctgcg ggatcaggcg 1078861 attttgagga agcgatttta acaactgata cggtgatcaa gcagacgtgc tatgaactgg 1078921 caatcggcgg caaaacagtc acgatcggcg gagcggccaa aggctctggg atgatacacc 1078981 cgaacatggc cacgatgctg ggatttgtga caactgacgc ggcaatcgaa gaaaaagcgc 1079041 tgcaaaaggc gcttcgggaa atcactgacg tttcatttaa ccaaatcaca gttgacggag 1079101 aaacatccac gaacgacatg gtattagtta tggcgaatgg ctgcgccgaa aacgagtgcc 1079161 tgacagaaga ccatccagac tggccggtct ttaaaaaagc gctcttgctc acttgtgagg 1079221 atctagctaa agagattgcc agagacggag aaggcgcgac aaaactaatt gaagcccaag 1079281 tacagggagc gaaaaacaat cttgatgcaa acgtcattgc caaaaagatt gtcggctcaa 1079341 atcttgtaaa aacggcagta tacggaacag atgccaactg ggggcggatc atcggagcca 1079401 tcggacactc cgcagcacag gtgacggcag aagaagtaga ggtttatctt ggcggccaat 1079461 gcctgtttaa gaataacgaa cctcagccat tctctgaatc tatcgccaag gaataccttg 1079521 aaggagatga aatcaccatt gtcatcaaga tggctgaagg ggacggaaac gggagagcgt 1079581 ggggctgtga cctgacctat gactatatca aaattaacgc gagctatcgc acgtaataaa 1079641 ggggagcgaa atgaagaaaa caatcgtttt taaatgcggg ggaagcgtca tccgtgagct 1079701 gtcggaggaa ttttatcaaa atctgaaaga gctgagggcg tcaggctgga agctggcaat 1079761 cgtacatggc gggggaccgg aaatcacaaa tatgctgaaa cggttaaata tcaagacaga 1079821 gttttcgggc ggacagagga aaacaacgaa gccggtgctg gaagtggcgg aaatggtttt 1079881 atccggttct gtcaataaat ttttcgttgc tgagcttgcc aaacacggac tgcgagccgc 1079941 gggcatttct ggtaaggatg gcggtctttt ggaggctgat tatctagatc cggaaacata 1080001 cggagaagtg ggagaaatca aaaaagtcga tgcgtccatg gtgaacgcgc tgatggaaaa 1080061 tggcatcatc cccgttattg cgccgctgtc tatgacaagc gactgcaaaa cgctgaatgt 1080121 aaatgctgat ctggctgctt cagcagtcgc cggagcgctt gaagccgata agctgatgtt 1080181 cgtcacggat gtcgatggaa tcatgaagga aaagcagcgt ctggacgtcc tgacccctaa 1080241 ggagattcag atgctgatca agcaggaagt gatcacagga gggatgatcc cgaaggtcaa 1080301 ttcagccttg tcagctttat cagatcaggt gtctgaagtc atgatcgtaa acggtaaagg 1080361 atcattcttc gcagaacaaa cctttcaagg gacaaaaatt gtcaaagcaa aggaggctgt 1080421 ttcatgagca gcttgtttca aacctacggc cgttgggata ttgacatcaa aaaagcaaag 1080481 ggaacgtacg ttgaggatca aaacggcaaa acgtaccttg atttcattca ggggattgcg 1080541 gtatcaaatc taggacactg ccatgaagcg gtgacagagg cagtcaaaaa acagcttgac 1080601 agcgtatggc acgtatccaa cctgtttcaa aacagtctcc aagagcaagc ggcgcagaag 1080661 ctggcagcgc atagtgcggg agatcttgtc tttttctgca acagcggcgc ggaggcgaat 1080721 gaaggtgcga taaagcttgc cagaaaagca actggaaaaa caaaaatcat cacttttctt 1080781 cagtcgttcc atggccgcac gtatgcaggg atggctgcga ccggacagga taaaatcaaa 1080841 acaggcttcg gcccgatgct tggaggcttt cactacctgc catacaatga tccttctgct 1080901 tttaaagctc ttggggagga aggcgatatt gccgcggtga tgcttgaaac agtgcaggga 1080961 gaaggaggag tcaatccggc gagtgctgaa tttttatcag ccgtacagtc gttttgcaag 1081021 gaaaagcaag cccttctcat tattgatgaa atccagaccg gcatcggacg gacgggaaaa 1081081 ggcttcgcat atgagcactt cggactctca ccggatatca tcacagtcgc caaaggattg 1081141 ggaaacggct ttccggtcgg cgctgtcatc ggaaagaaac agcttggaga agcgtttacc 1081201 cctggttctc acggaacgac tttcggagga aacatgctgg cgatggctgc tgtgaatgcc 1081261 acattgcaaa ttgtattcca gcctgacttt ttgcaagagg ctgctgacaa aggggcgttt 1081321 ttaaaagaac agcttgaggc agagctaaag agcccttttg ttaaacaaat ccgaggtaaa 1081381 ggattaatgc ttggaattga gtgtgatggc ccggttgctg acattattgc tgaattgcag 1081441 acattaggct tgcttgtatt gccggccggc ccgaacgtga ttcggctgct gccgccgctc 1081501 accgtgacta aggatgaaat agcagaagcc gtcagcaagc tgaaacaggc aatcgctcat 1081561 cattccgctg taaaccagtg attttttttc gatataaagg cataaaaatt catttttata 1081621 attaattatt catcaagagg tgggctgtta gatggaaggt tatttagtgt tagaagatgg 1081681 gacatcgttc agcggcgagc tggacggtca tgaaaactgc acgggagaag ctgttttttt 1081741 cacaggaatg acaggctacc aggaagtgct gacagatcca tcatataagg gacagattat 1081801 tgtatttacc tacccgctga ttggcaacta cggcataaat gaaaaggatt ttgaaagcaa 1081861 gaaaccgcaa gtaaaagccg cggttgtcta tgaggcgtgt gatcactttt ctcattatga 1081921 agcggtatac agcctcaagg agtatctaca gaaatggaat attccgctgt taacccatgt 1081981 tgatacgagg gctgtcgtga agaaaatccg ggcaaacggg acgatgggtg cgacagtcac 1082041 agcctctaaa gaaggagctg agattgccct tcaaccagag aatgtggcag agcaggcttc 1082101 cgcccaggaa atcagcacat tcggcgacgg gaataaacat atcgctctca ttgattttgg 1082161 ctataaaaag tcaatcgcat catcacttgt caaacgaggc tgcaaggtta ccgtggtgcc 1082221 ataccagcaa atggaggccg tatacaacat caaacccgat gggctatcga acggacctgg 1082281 agatccgaaa gccattcagc catatttagg aaagatcaaa agcatcatca gccgctttcc 1082341 gactctaggc atttgtctcg gacatcagct gatcgcgctc gcgtttggag ggaatacttt 1082401 taagctgcca ttcgggcaca ggggagctaa tcatccggtc atcgaccgta agacgaaacg 1082461 ggtctttatg acaagccaaa accacagcta tgtggttgat gaacagtcga ttaatgaaga 1082521 agagctcacc atcaggtttc atcatgtcaa tgatacgtca gttgaagggc ttgcccataa 1082581 aaaactgcct gtcatgagtg ttcaattcca cccggaagcc catcccggac ctgcggaaag 1082641 cgaatggatt tttgatgatt atctaaagaa tgtgatacca gcaaggagag aaatcgcgca 1082701 tgcctaaaga caccagtatt tcaagcatat tagtaattgg ctcaggcccg atcatcatcg 1082761 ggcaggcggc agaatttgat tattcaggca ctcaagggtg catcgcgctg aaggaggagg 1082821 gctaccgggt aattctcgtc aacagcaatc cggcgacaat tatgactgat gaagccttcg 1082881 ctgatgaaat ttattttgag cctctgacag cagaaagcct gacagccatc attaagaaag 1082941 aacggcctga tgggcttctt gccaatttag gcggtcagac cgcgttgaat ttagcggtgg 1083001 agcttgaaga aacgggtgtt ttaaaagagc acggcgtcaa actcctcggc acatccgttg 1083061 aaacgataca aaaaggagag gaccgggaaa aattccgttc gttaatgaat gaattaaaac 1083121 agcctgtgcc ggagagtgaa attgttgata acgaggccga tgccctccat tttgcggaat 1083181 ccatcggttt tcctgttatt atcagaccag cttacacatt aggcggaaag ggcggaggaa 1083241 tcgcccctga taaagaagcc tttacagcta tgattaagca ggcgctatta gcaagcccga 1083301 tcaatcaatg ccttgtcgaa aaaagcattg ccggctttaa agaaattgaa tatgaagtca 1083361 tgcgtgacag caataacaca tgcattaccg tctgcaatat ggaaaatatc gatccggtcg 1083421 gcgtgcatac aggtgactct atcgttgtgg cgccgtcaca aacattgaca gacgaagact 1083481 atcaaatgct gcggacagca agtctgacga tcatctcagc acttgatgtt gtaggcggct 1083541 gcaacattca attcgcgctt gatccattca gcaagcaata ttacgtcatt gaagtgaatc 1083601 cgcgtgtaag ccggtcatcg gctctcgcat ctaaagcgac cggttatccg attgcgaaga 1083661 tggccgcgaa actggcagtc ggatacactc ttgacgagct gaaaaatccg ctcacaggct 1083721 cgacttacgc aagctttgaa ccggcactgg attatgtgat cgtcaaattt ccgcgctggc 1083781 cgtttgataa attcaaaaac gcagaccgca agcttggcac aaaaatgaaa gccaccggtg 1083841 aagtgatggc gattgaacgg aatttagaag cggcgataca aaaggcagcc gcgtcgcttg 1083901 aattaaaaaa tatcgggaca caccttccag agctcagcgg gttgtcaatt gatacgctat 1083961 gggatttggc aatcactccg gatgaccgca gatttttcgt tgtcatggag ctgttgagcc 1084021 gcagcgtctc gattgatgac atccatgaaa aaacaaaaat tgatccgttt ttccttcata 1084081 cctttgacaa catcatcaaa ttggaaaacc gcctgatgga agcagggagc gatctctctt 1084141 ttgaattatt gaagaaagca aaggaaaagg gattctcaga cgcaacgatt gcctcgctga 1084201 tcagcaaaac agaagaagag gtgcgcgcgc ttcgcaagga gatgggcatt acgccttcct 1084261 ttaaaatcgt agatacatgc gcggcagagt ttgatgcgaa aacaaactat ttttactcca 1084321 catatttcgg agagaccgat ggagacatca gccgcaaaga gaaaaaacgc gcgctcatta 1084381 tcggatcagg cccgattcgg atcggccaag gcgttgaatt tgattacagt gctgttcacg 1084441 gtgtgctgac actgcaagag cttgggttcg aaaccatcat gattaacaat aacccggaaa 1084501 ctgtcagcac cgattatgaa attgcggacc gcctgtattt tgaaccgatg acaacggagc 1084561 atattgtaaa cgtggcggag caggaaaata ttgattttgc aattgtgcaa tttggcggtc 1084621 aaactgcaat caatgctgct gaagcgctcg aaaaagccgg cattactctt cttggcacat 1084681 catttcaaac gctcgacgtg ttagaggatc gggatcaatt ttatcagctt cttgacgagc 1084741 tgggattgaa gcacgcaaaa ggagaaattg cttatacaaa agaagaagcc gcttcaaaag 1084801 cgagtgagat cggctatccg gtgttaatcc gcccatctta cgttatcggc ggaatgggca 1084861 tgatcattgt tgactcgcaa gcccagcttt ctcagctgct gaatgatgag gacagcatgc 1084921 catacccgat tttaattgat cagtatgtgt ctggaaagga agtcgaaatt gatttgattt 1084981 ccgacggcga ggaagtcttt atcccgacat ataccgagca tattgaacgg gcaggtgtcc 1085041 attcagggga cagttttgcc attcttcccg gaccgtccat cacgagcggg ctgcagcagg 1085101 gcatgaaaga tgcggcacaa aaaattgccc gaaaactttc atttaaaggc atcatgaaca 1085161 ttcaatttgt gatcgacaat ggaaacatac tcgttcttga agtgaatccg agagcgagcc 1085221 gcacggttcc tgtcgtcagc aaagtaatgg gcgttccgat gattccgctc gccacacgtc 1085281 tgctggcggg agcgtcctta aaagatctaa atccggcagt tcaaaatcat catggagttg 1085341 ccgtgaagtt ccctgttttt tcttctcatg cgatccagga tgtggatgtc aagcttggac 1085401 cggaaatgaa atcaacggga gaaggcatgt gtgtcgcata tgattctaac agcgccttga 1085461 aaaaaatcta tacaagagtc tggagtcaaa aaggaagcat ttatttgcaa aacgttccgg 1085521 aagatgtgaa ggagttagca gaaaacgcag gttttacaat acatgaagga acatttgcct 1085581 catggatgga acaggaagga aactcgctcc acattaatct gagcggttct gaagaagcac 1085641 gcaaagaacg tttggaagcc atgacgcacg gcatccccgt ctttacagaa gaagaaactg 1085701 tgcgggcgtt tttacaaagc ggttcaggcc atccgcagcc tgtatctctc aaagacctct 1085761 ataaaaagga agtggcatca tgcacacagt gacgcaaacc agtttatacg gaaaagattt 1085821 attaacgtta aaggacctta gtgaagaaga tataaacgcc ttgctcgcag aagccggtga 1085881 gctgaaacaa aacaaaattc agcctatatt ccatggcaaa accttggcga tgatttttga 1085941 aaaatcatca acgcggaccc gtgtttcatt tgaagcgggc atggcgcagc tgggcgggag 1086001 cgccctcttt ctaagccaga aagatctgca gctggggcgc ggtgagactg tcgctgatac 1086061 ggcaaaagtg ctgtcaggct atgtggatgc catcatgatc cggacctttg aacatgaaaa 1086121 ggtggaggaa cttgccaaag aagctgacat tccggtgatc aatggactta ccgataaata 1086181 ccacccatgc caggcgctgg cggatctctt gacgattaag gagataaaag ggaagcttaa 1086241 aggcgtaaaa gtcgcgtaca tcggtgacgg aaataacgtg gcgcactcct tgatgatcgg 1086301 ctgcgcgaaa atgggctgtg atatctcgat cgcttcacca aagggatatg aagtgttaga 1086361 tgaagcagct gaagcggcaa agacatatgc acttcaatcc ggctcttctg tcacgctgac 1086421 agatgatccg attgaagctg taaaagacgc ggacgtgatt tattctgatg tgtttacaag 1086481 catggggcag gaagcggaag agcaagaacg tcttgctgtc tttgcgcctt atcaggtgaa 1086541 tgcggcgctg gtcagccatg ccaagcctga ctatacattt ttacattgtc tccctgcgca 1086601 tcgcgaggaa gaagtgactg cggagattat tgacgggccg aactctgcag tgttccagca 1086661 ggcggaaaac cgtcttcatg tgcaaaaagc actgctgaag gccattttat ataaagggga 1086721 atcatcaaaa aactgctgag ccaaactcag cagttttttt gatggcaaca tattcacagc 1086781 cgcttaggcg catactacag caaaaaggaa aaggaggaaa aacagtggga cagcagcacc 1086841 aattccggcc cggacagaaa gcgcctaata acggtgtcta cgtagaaatc ggcgagacag 1086901 ggagcatggt taaaaaccct caaaaggtcc atctgtcagc aggggaaatg ttccccgaaa 1086961 catcaaacca caaccggctg tggacctaca aaagaaagcc gtgaccacta aaaaacccaa 1087021 aacaataaat gttttgggtt tttggctttt taatgctggc ttgcattttt gttcataggc 1087081 atgatttctg ctaaaaccat gattaagaca tacagtacaa cagcaatgac agatgatgtt 1087141 ttgaaattat acgtaacgct gttcatgctt gcaaccaagt agcatgccat atgtgataaa 1087201 aggaacgtcc aaataaaggc aataatatat cgcacgtttc cacctcgtcc ttctcattct 1087261 attctaaaag ttatcatacc atacaaaaag cgaaggggga atccaatttt agcagaaagt 1087321 gaggtgacaa aagagtctga ttcgtcacac tttaatggta aaatataaaa cgtcaatcag 1087381 tataatagcc aaaaatgtaa aaggctagga ctttacctta ttcgtttctt ttctatttac 1087441 ataagatagc gtgagatgaa gtgtgaaagg aggcgggcaa gcgatgggaa taacggaaag 1087501 atactttcaa ctgggaacgg agcataatgt cattcatctg ccctatcgcc cgaacggctt 1087561 cggcatcttt atcttggggg acagaaccca ctttgtcgga catgattcaa gcttttggca 1087621 gcagcattat ggcagaaatc agcttctgag catgttgatg aatgaaggat acactctttt 1087681 taacagcaat ctgttcggaa ggcattgggg ggcggaaaaa gcagtcacct atgccaaaca 1087741 gctgatacat tctgtgctga agcaggaaat cctcaatccg aagattcata ttttagcaga 1087801 aggcatgggt gctctcgtgg ccgatgaact gcttcgtttt tccccggatc atatccgctc 1087861 agccgcaatg ttgaatcctt gtctcgatct tcaggcacat tatgaatcgg aaaaagaaaa 1087921 taaatttttc tataagcaat ttttgaaaga agtatcgaaa agctacggaa tttctgaaaa 1087981 agaagcggaa gcgattcgtt ataaaacaat tcaaagctac ccgagcggcg taccggttca 1088041 tatatggcag cgtatgaccg gagctccata tccctacagc gtacatgcgg aagttttcaa 1088101 ggaaaaacag caaaagcaag gctcaccggt cgacatgaca tttcatttat ttgagcatcc 1088161 aagcagaatt tatgcatcaa tttgcaaatt ctttcatagt catgaaaaag aattatagag 1088221 aatataatga caacagcctt ctcttttgcg gaggctgttt tgttttggga aatgaaaaac 1088281 cggaagggcg gcagatgcaa tggaatcaac gctgattgta ggtgcggacg aatttttcgg 1088341 cctttcatta tgtgagcgaa tgatggatga aggcatacat gttgacgttg ttctggcgga 1088401 aacagaagat aaaatgagac aaatgtactt agaagaaaga ctcatgtggc ttgggagaaa 1088461 tgaactcttt cgccagcttg aacacattgg agaccaaaat tatgatacaa tttgtatcca 1088521 gttcggaagt tttttgcctt tagaccaata tgattctcct tatattttag tatatgaaga 1088581 agaccgaaaa gaatgggata aacgtgaaaa aacaggctcg gaaaaaaccg tgatcctgcc 1088641 gaaaatgtac gggccatgga aagaagaaac agaggaagac ggctattaca caaacgacgt 1088701 ggctgacgag ttgctgagat tcctgttaga accaagccgt catagcaaag atcagctttt 1088761 tgaattgcaa gtcacagaga aaacctcaaa agaagaagca aaaacaaaaa ttatcgagtg 1088821 gaaaagacaa ttttcatcaa ttttcgacaa atattaagaa aaaccttcca tgtttcgagt 1088881 tttctagata caataaacgt ataaaaataa tacatgttat agcttgtcaa aaggagttga 1088941 acatgacttg atcacaaggc ttgtcatgat cttttctgtc ctccttttat tgagtggatg 1089001 tggacaaact ccgttcaaag gaaaaattga gaaggtcggc atgctctttc ctgatacgat 1089061 taatgacctc gtatggggca caaaagggta taaaggatta ctgaatatac aatccaaata 1089121 caatgtggac gtctattata aagaaggcgt taaaacagaa gaagatatca taaatgcgat 1089181 tgaggatttt cataagaggg gcgtcaatct gctctacggc catgggagtg aatatgctga 1089241 ggtgtttaac ttggtcggcg aagattatcc agatatggaa ttcgtcattt ccaatgcgaa 1089301 agcgaaagct gataatgtaa caagtgtcca ttttagcggg gaagcaatgg gcttttttgg 1089361 aggaatgact gctgcccata tgtcgaaaac gaatcaggtc ggtgtaattg cttcctttac 1089421 gtggcagcct gaggttgacg gttttatcaa aggggccaag tatgaaaatc cggatataga 1089481 ggtaaatacg aaatatacgg atcattggga tgatgataca acagcagtaa agctttatca 1089541 gaaaatgaag aacgaaggcg cggatgttgt gtatcccgcc ggagacgggt ataatgttcc 1089601 tgttattcag caaatcaaaa aagacggtct ttatgccata ggctacgtca cagatcaatc 1089661 ggatctgggc gagaataccg tattaaccag cacggtgcaa aatgtggaca aggcctatga 1089721 aatcattgct gaacaattta ataaaggcac ccttgagggc ggcgatcatt actacgacct 1089781 gaacacggga gtcgttgaga tgggaacatt cagcccgctc gtcgatcaag actttcagca 1089841 aagaatcgcc aagctgatca aaacatacaa caaaacaggc gagctgccaa aaaacgagta 1089901 atggagtgac gtcacatgca gcacgaaaaa tcacttgaat tcttgcaaat tgccatgaaa 1089961 tatctccctg aagcgaaaga acagcttgag aaatcaggca ttgagctctc aatggaggcc 1090021 atccagccgt ttatgaatct atttacaacg gtaatggcgg aagcttatga gcttggcaag 1090081 tctgacgcta aatctgaaac agaataagaa gaagccactt ttttgaaagt ggcttttcac 1090141 atgattttct ttttaatagc ggagagcatg ggcgcaagct cctttaaagc gggcttgatt 1090201 tgatcaagag agttcataat tgaaccgatt tggtccataa tatgcatgta attaatcgtc 1090261 tcttcgtcgt ttgtctgaga aacctgagaa acttcctctt gctgttcctc ctccttctct 1090321 tctgttggtt ttgctgcatc gccgaacatc attcttgaaa acacatccaa ctgcatacgc 1090381 ctcctttcca tataccatac tctatgagta agatgaactg atagtttaga cgaatatatt 1090441 gccatgtgaa aaaaaatagg atagaattag tacctgatac taataattga tcacaacctg 1090501 attgatcttc taaatttaag atataaagga gtcttcccta atgaaagctg gaatacttgg 1090561 tgttggacgt tacattcctg agaaggtttt aacaaatcat gatcttgaaa aaatggttga 1090621 aacttctgac gagtggattc gtacaagaac aggaatagaa gaaagaagaa tcgcagcaga 1090681 tgatgtgttt tcatcacata tggctgttgc agcagcgaaa aatgcgctgg aacaagctga 1090741 agtggctgct gaggatctgg atatgatctt ggttgcaact gttacacctg atcagtcatt 1090801 ccctacggtc tcttgtatga ttcaagaaca actcggcgcg aagaaagcgt gtgctatgga 1090861 tatcagcgcg gcttgtgcgg gcttcatgta cggggttgta accggtaaac aatttattga 1090921 atccggaacc tacaagcatg ttctagttgt tggtgtagag aagctctcaa gcattaccga 1090981 ctgggaagac cgcaatacag ccgttctgtt tggagacgga gcaggcgctg cggtagtcgg 1091041 gccagtcagt gatgacagag gaatcctttc atttgaacta ggagccgacg gcacaggcgg 1091101 tcagcacttg tatctgaatg aaaaacgaca tacaatcatg aatggacgag aagttttcaa 1091161 atttgcagtc cgccaaatgg gagaatcatg cgtaaatgtc attgaaaaag ccggactttc 1091221 aaaagaggat gtcgactttt tgattccgca tcaggcgaac atccgtatca tggaagctgc 1091281 tcgcgagcgt ttagagcttc ctgtcgaaaa gatgtctaaa actgttcata aatatggaaa 1091341 tacttctgcc gcatccattc cgatctctct tgtagaagaa ttggaagccg gtaaaatcaa 1091401 agacggcgat gtggtcgtta tggtagggtt cggcggagga ctaacatggg gcgccattgc 1091461 aatccgctgg ggccgataaa aaaaggtgag gtgcacacaa gatgactaaa aaaagagtag 1091521 ttgttacagg acttggagca ttatctccac ttggcaacga cgtcgataca agttggaata 1091581 acgcaatcaa cggtgtgtcc ggaatcggtc cgatcactcg tgttgacgct gaagaatatc 1091641 cggcaaaagt tgccgctgaa ttaaaagatt ttaatgttga agattatatg gataaaaaag 1091701 aagccagaaa aatggaccgc tttacacaat atgcggttgt ggctgcgaaa atggcggttg 1091761 aagatgcaga tcttaacatt accgatgaga tcgcgccgag agtcggtgtt tgggtaggct 1091821 ccggtatcgg aggacttgaa acactagagt ctcaatttga aatcttctta acaaaaggcc 1091881 caagacgggt aagcccgttt ttcgtgccaa tgatgattcc tgacatggcg acaggccaga 1091941 tttctattgc attaggagca aaaggggtga actcttgtac ggttacagca tgtgctacag 1092001 gaacgaactc catcggtgac gcgtttaagg ttattcagcg cggtgatgca gacgtgatgg 1092061 tcacaggcgg aacagaagcg ccgctgacaa gaatgtcatt cgccggcttt agtgccaaca 1092121 aagcgctgtc tactaatcca gatccgaaaa cagcgagccg cccgtttgat aaaaaccgtg 1092181 atggctttgt catgggggaa ggtgcaggga ttatcgttct tgaagaactt gagcatgccc 1092241 tggcccgcgg cgctaaaatt tacggagaaa ttgtcggcta cggctcaacc ggagacgctt 1092301 atcatatcac agcgccggcc caagacggtg aaggcggagc gagagcgatg caagaagcca 1092361 ttaaagatgc aggcattgca cctgaagaaa ttgattacat caatgctcac gggacaagca 1092421 cgtattacaa cgacaaatac gaaacaatgg cgattaagac cgtttttggc gagcatgcgc 1092481 ataaacttgc ggtaagctct acaaaatcga tgacaggcca cctcttagga gcagccggcg 1092541 gtattgaagc cattttctct atcctggcca ttaaagaagg cgtgattccg ccgacaatca 1092601 atattcaaac acctgacgaa gaatgtgatt tggattatgt gcctgatgaa gcccgcagac 1092661 aggaacttaa ttatgttctc agcaactcat taggattcgg cggacacaac gcaacattaa 1092721 tctttaaaaa atatcaatca taatcaagcc aaaccggctg cccttaaagg gtagccggtt 1092781 ttttttgtgt gcataggatt aaaagaggag gcgatcacat gagtgtagaa caaacatata 1092841 gctggctcag gaaggccggt tcaatagatg atttggcgca ttacattatc ccgctttttt 1092901 caggtgcgga gaaaaagaac tggaagggca ttctggggca tcttcagcat catgggatgt 1092961 ttaaaaacat aaaagagggt attcagacgg tttccaagct gaaggaaaaa ggtttttacg 1093021 gacatatcca aaaggaagaa cagtacctca aaaacaaatg gcaaggtcct gatgtaccaa 1093081 ttgttacgct gccggttgat gaacgaaaca ggagaatccg tttagaattc ggatcaaaat 1093141 caggactcgc ctttcaagac aaaatgttcc tttttctttc gtcagattta gattttgggt 1093201 cggtatctgc ccttatgacg catgagtatc atcacgtttg ccggttaggt catctgacaa 1093261 aagaggaaaa ggatgtcaca ttacttgata caatcatcat ggaagggctg gcggaatatg 1093321 ctgtttatga gaggttcggc cgaagtcaaa cggctgaatg gacgacttgg tatacaccgg 1093381 aacagcttca ggctttatat gaaaaaaaga ttgcgcccca tcgggatatc aaacgggata 1093441 atcgattatt tccccagctg ttattcggca aaggatatca gccaaaaatg cttggatacg 1093501 cagttggatt caatattgta aaaaaatatt taaccgccag caaggcaagc accgcagacg 1093561 ggctgtccat tcctgctgag acctttttgg atgcaatgct ttaaaaggat aaaataatgg 1093621 aatttcatta ataatattac atttatccta aaaaattctt gattttgcaa aatgattgta 1093681 ataatataca actataaaat ttttcgataa ttcaatatta tttattattt ctgaataaag 1093741 ggattgcttt ctcttgaaaa cgtttgacaa caagaggggg gaaaggggag ctagcatgag 1093801 cacactttta gaagtgaata atttaaagac ttattttttc aggaaaaagg agccgatccc 1093861 tgcggttgac ggagtcgatt ttcacatcag caaaggcgaa accgtcgcgc ttgtaggtga 1093921 atcgggctcc ggaaaaagca ttacttcttt atcaattatg ggcctcgtcc aaagctcagg 1093981 cggaaaaatc atggacggct ctattaaact cgaagacaaa gacctcacct cattcactga 1094041 aaacgattat tgcaaaatcc gcggtaacga agtatccatg atctttcagg aaccaatgac 1094101 ctcccttaat ccggtgttaa caatcggaga acaaattacc gaagtgctga tttaccataa 1094161 aaacatgaag aaaaaagaag cccgtcaacg agctgttgaa ctcttgcaga tggtcggttt 1094221 ctcccgggcg gagcaaatta tgaaggagta cccgcatcgg ctgtccggcg gtatgagaca 1094281 gagggtgatg attgccatcg cactgagctg taatcctaaa ctgctcattg ctgatgaacc 1094341 aacgacagcg ctggacgtga caatacaagc ccaggtgctg gagctcatga aagatctctg 1094401 tcagaagttc aatacatcga ttcttctcat cacacacgac ttaggtgtcg tgtctgaagc 1094461 tgccgataga gtgattgtca tgtactgcgg acaagtcgta gaaaacgcca ctgttgatga 1094521 cttattttta gaaccgcttc atccgtatac agaaggcctg cttacgtcaa ttcctgttat 1094581 agatggagag attgataaat taaatgcgat taaaggcagt gtgcctacac cggataatct 1094641 gccgccgggg tgccgttttg ccccaaggtg cccgaaagct atggataagt gctggacaaa 1094701 tcagccttcg cttttgacac acaaaagcgg aagaacggtg agatgctttt tatatgagga 1094761 agagggtgcc gaacaatcat gacagcagct aatcaagaaa caatcttaga gcttcgtgac 1094821 gtaaaaaaat actttccgat ccggtcaggc ctttttcaaa gaaaagtcgg tgatgtaaaa 1094881 gcggtggatg gtgtttcatt ttcgttaaaa aaaggagaaa cactcggaat cgttggagag 1094941 tcgggctgcg gaaaatcgac tgccggcaga acgatgatca gactgtacaa accgacagag 1095001 ggccaaattc tttttaaagg gcaggatatt tccaatctgt cagaggagaa gctgcggaag 1095061 agtgtccgca aaaatattca aatggttttc caagatccat ttgcttcgtt aaacccgaga 1095121 aagaccctgc gttccatcat aaaggagccg tttaatacgc acaacatgta taccatgcgt 1095181 gaacgaaacg aaaaagttga agagctgctt gcaagagtag ggcttcaccc gtcgtttgcc 1095241 ggccgttatc cccatgagtt ttcaggcggc cagcgtcagc ggatcggcat tgccagagca 1095301 ctcactttga atccagagct gatcattgca gatgagccgg tttccgcact tgatgtatcc 1095361 attcaggccc aagtgattaa cttgatggag gaattacagg aagaatttaa tcttacgtat 1095421 ctatttatct ctcatgatct gagtgtcgtc cgccatatca gcgacagagt cggagtaatg 1095481 tatcttggca aaatgatgga actgaccggc aagcatgagc tttatgacaa cccgcttcac 1095541 ccatataccc aagcgctttt atcctccgtt ccggttacaa gaaaaagagg ttctgtcaaa 1095601 cgtgaacgca ttgtcctgaa gggagaactg cctagtccgg ccaacccgcc aaaaggctgc 1095661 gtattccaca caagatgtcc tgttgcaaaa ccgatatgca aggaacaaat accagaattt 1095721 aaagaagctg ctcccagcca ctttgtggct tgtcaccttt atagctaatg ttgcccgcac 1095781 agctttgaga gggggtatgc acactacata aacaacagcc tagaagaacg aacatttcaa 1095841 gagggggaat atctaatgaa aagacggaaa accgcactga tgatgctaag tgtattgatg 1095901 gttctggcca tctttttatc agcctgctcg ggatcaaaat caagcaacag cagcgcgaaa 1095961 aaatcagcag gcaaaccgca gcaaggcggg gatttggttg ttggttcaat cggagaaccc 1096021 acacttttta actctctgta ttctaccgat gacgcaagta cggatattga aaatatgctg 1096081 tacagctttt taacgaaaac ggatgaaaaa ctaaatgtga aattgtcact cgctgaaagc 1096141 attaaagaat tagacggcgg ccttgcatat gatgtgaaaa ttaaaaaagg cgttaagttt 1096201 catgacggaa aagaactgac tgcagacgac gtcgtattta cgtacagtgt ccctttaagc 1096261 aaagattaca agggagaacg cggttcaaca tatgaaatgc tgaaatccgt agaaaaaaag 1096321 gcgattacga agtcttgttt aagctgaaat ataaagacgg taatttctac aacaatgcgt 1096381 tagacagcac agctattctg ccgaaacata ttctcggtaa tgttccgatt gctgatttag 1096441 aagaaaatga gtttaacaga aagaaaccaa tcggttcagg accatttaag tttaaggaat 1096501 ggaagcaggg ccaatatatt aagctcgaag cgaatgatga ttactttgaa ggaagaccgt 1096561 atttagatac tgtgacgtat aaagtcattc ctgacgcaaa tgctgccgtt gctcagctgc 1096621 aggcaggcga tattaatttc tttaatgtgc ccgccactga ctacaaaacg gctgaaaaat 1096681 tcaacaacct aaaaatcgtt actgatttgg cattaagtta tgtgtacatc gggtggaatg 1096741 aaaaaaatga attattcaag gataaaaagg ttcgtcaagc gctaacaacc gctcttgacc 1096801 gcgagtcaat cgtcagccaa gtattagatg gagacggcga ggtagcttac attccggaaa 1096861 gccctttatc ttggaactat cctaaagata tagatgttcc gaaatttgag tacaacgaga 1096921 aaaaagcgaa acagatgctt gcagaagccg gctggaaaga tacgaacggt gacggcattc 1096981 tggataaaga cggaaagaaa ttctcgttta cccttaaaac gaaccaagga aacaaagtcc 1097041 gtgaagacat cgctgtcgtc gttcaggaac agctgaaaaa aatcggcatt gaagtgaaaa 1097101 cccagatcgt tgaatggagc gctctcgttg aacaaatgaa tcctccgaat tgggattttg 1097161 atgcaatggt catgggatgg agtttatcca cattcccgga tcaatatgat attttccatt 1097221 caagccagat taaaaagggt ttgaactacg tttggtataa aaatgccgaa gcggataaac 1097281 tcatgaaaga tgcaaaatca atcagtgaca gaaagcagta ttcaaaagaa tatgagcaaa 1097341 tctatcaaaa aattgcggaa gatcagccgt atacgttctt gtattatcct aacaaccata 1097401 tggcaatgcc ggaaaatctt gaaggataca aatatcatcc gaaacgtgat ttgtataata 1097461 ttgaaaaatg gtggcttgca aaataaattt cccttaaagg ggagggagag cgttttctcc 1097521 ctcttctgtt tttaataagg aaagtaaagg gggacaagta tatggctgca tatattatca 1097581 gaagaacctt aatgtctatc ccgattttat tgggaattac gattttatca tttgttatca 1097641 tgaaagccgc gcccggagat ccgatgacat taatgatgga cccgaaaatc agccaggctg 1097701 acagagagca gtttattgaa aaatacggtc tgaatgatcc tcagtacgtt caatatttaa 1097761 agtggctagg caacatggtg cagggtgatt tcggaacgtc tattgtcaga aaaggaacgc 1097821 ctgtttcaga attgattatg gcaagactac ccaatacgct cctgctgatg ctggtttcaa 1097881 cgattttggc tcttatgatt tctattccgt tcggtgtcct gtcggcaaag cggccgtatt 1097941 caaaaatcga ctatggcatt acatttacct cgtttatagg cctggctatt ccaaactttt 1098001 ggtttggatt aattttgatt atggtgttat cggtaaatct cggctggttt ccaactgggg 1098061 gtgtcgagac actgaatacc gaattcaata tatttgaccg gattcatcat ttaattctgc 1098121 ctgcattcgt tctagctaca gctgacatgg ccggactgac gagatacacg agatccaata 1098181 tgcttgatgt attaaatcaa gattatattc gcacagcgag agcaaaagga tttaaagaga 1098241 acagagtgct atttaaacat ggattgagga atgcattatt acccgtcatt acaattttcg 1098301 gtttgatgat tccttcattt atcggcggat ctgtcgttgt cgaacaaatt ttcacttggc 1098361 cgggattagg aaagctgttt gtcgattcag cattccagcg cgattatccg gttatcatgg 1098421 caatgactgt gatctcggcg gttcttgtcg ttgtcggaaa cctcattgca gacatccttt 1098481 acgcgattgt tgatccgcgg atcgaatatt aaaaggaggg aaacagagat gtcagagctg 1098541 caaacaactc cctcgccgga gatcaggctg aaagaaaata tttcgaaaaa gccagaaaca 1098601 atgacaaaga ttttctggga aaaattctcg aaaaacaaac tggccatttt aggtgccgtt 1098661 attcttttta tcattattat gtctgctgtt ttcgcccctt taattgcacc ttatccccaa 1098721 gagcagcaaa gcctgcttga taaatataag gcgccgggcc ttgaacatct gatgggaacg 1098781 gataaatttg gacgtgatat tttcagccgg atcctatatg gagcgcgtgt ctctttattg 1098841 gttggatttg cgtccgtagt cggttcgatt ttgatcggaa cggttttagg agcattagcc 1098901 ggatatttca gaggaatagt ggatgctgtc attatgcgtg tagttgacat tgtgttatcc 1098961 attcctgata ttttcttgtt gatcacgctg gtcaccatct tcaagccggg tgtggacaaa 1099021 ttgattttaa ttttctgtct cacaggatgg accacaacag cacgattagt aaggggagaa 1099081 ttcttgtcgc tccgttcaag ggaatatgtt cttgctgcta aaacaattgg aacaaaaacg 1099141 cacaaaatta ttttttctca tatcctgccc aatgcgttag ggccgattat cgtgtcagct 1099201 acgctgaaag ttgggtctgt tattctagct gaatcggcgc taagctactt gggctttgga 1099261 atccagccgc caatcgctag ctgggggaac atgcttcaag acgcacagaa tttcacagta 1099321 atgattcaag catggtggta cccgttattt cccgggctat ttattttaat gaccgtttta 1099381 tgcttcaact ttgtcggtga tggcctgcgg gatgcgcttg acccgaaaaa tattaaataa 1099441 aaatgaatat catatctgtt ataaaatatc accaaatcag aaaaaagcag gtctccttta 1099501 gtcagaaaat atacaaagag atctgctttt tatgattctt acataaaccc agtgattcca 1099561 gatttcctca atctctttgg aataatttct ctatcccttg cctatactgt ggacaacagt 1099621 ttttataaaa gtgaggggtt agagatgtta tttcttcatg atgtgtgggt caattggttt 1099681 gaaggggaag aaaatggcta caatgtatgc cactttcacg aatggcgcaa ggaagatacg 1099741 gttgagcttt tggatcaggt gccgctgtta agggtgccgt cagtactgtt tcattacata 1099801 gaaaacgatt tgtcagagct tccgaaaggt ttgcttgaag acgtacatca gaaatcgtac 1099861 attcgaaaaa atcatgagcg gacaaagctt gagtattgtt ttgtcgtaac agacggaatc 1099921 ggcattttag ctgttgacac gatcggctac acgatccctg tcagaaaaag ccgtctaatc 1099981 ccaagacagg agcagctcgt ttatgaaatg gtaaaagatg tagagcctga aacatatgaa 1100041 tttgagccaa agaagctgga atcctccaag gaatatcaca tcttatcatt agcaccagaa 1100101 catgtcagag gactgacaag aaaagaacgg caaattaagc agctgatgtt tatggcgctt 1100161 gaccaattaa aagggctgaa aaaccgagcg gaaattggct actggtacac agagtggaat 1100221 ccgcatatgt atgaacaaat caaaaggatg agctttgaag agatttggga catgctgtat 1100281 aacgaaacaa ttgaaggctg gtcggacaaa cacctagctt tttgcgaaaa cctaataaaa 1100341 ggacagcctt ttttcgaaaa gctttgggaa atggaaaacg aatcaaaggt caactgaaaa 1100401 aaaccgctct ttgcaaagag cggttttttg attagcgtct ttttcttcca agacccatgg 1100461 cattctccat ttttttcagc attttgtttg ctgtccgatt cgctcgttcc gcgccttcat 1100521 caagaatccg gtctaattct tcagattcta tcagctcgta atagcggtcc tggatcggtt 1100581 ttaatgcgtt cactacgact tctgccaaat cacctttaaa ctcgccgtag ccttttcctt 1100641 cgtactttgc ttcaagctct tcaattgtcg tattgccgag gattgaataa attgtaagaa 1100701 ggttggaaac gcccggtttg ttttccttat caaatttgac aatgccttca gaatccgtta 1100761 ctgcgctttt gattttcttt tcaagctgct tcggctcatc cagcaatgta atataagctt 1100821 tctgattcgg atcagatttg ctcattttct tcagcggatc attcagagac atgatacgtg 1100881 caccgacttt tggaattttc acttccggaa tcgtaaagat gtcgttgtat tttttgttga 1100941 agcgttctgc aagattccgc gtcagctcaa ggtgctgctt ttgatcctcg ccgacaggta 1101001 caagatccgt tccgtacagc agaatatcag cggccatcag cggcggatat gttaacaggc 1101061 cggagacgac agcttcattg cctttggatt tgtccttaaa ttgagtcatc cgctcaagct 1101121 cgccgatata ggcgacacac tgcatcatcc atccggcctg cgcatgtgcg gggacctctg 1101181 actgaataaa caatgttgct ttttctggat caagtccgac agctaagtaa agcgccgcga 1101241 gattgcggat attctttcta agctcaagcc ggtcttgagg aacagttatc gcatgctgat 1101301 cgacgatgca aaaatagctg ttataatcat gctgcagttc gacaaactgc ttcattgcac 1101361 cgatatagtt gccgagcgtc actgagccgc ttggctgaat gcctgaaaaa atcgtttgtt 1101421 tcatgaaaac atcaacctca tttcttaaaa cataataaaa aaggctcatt cttcccctgt 1101481 aaaaaaggga cgaatgaacc gtggtaccac cctgattatt ccattaaaat ggaatcactc 1101541 tgacgtttgt aacggagact gctccggctg agcctacttt tttccagttc ggtcagctgc 1101601 tccaaagtcc attccacatt gcccgttatc tgctcccagc accgcagact ctcttcaaac 1101661 aggtgaaacg tgtactactc tttttcatag caagcttttc ttttgattgc ttcattataa 1101721 atcaattata accaattgtc atcatgaaaa aacattcttt tttccagtaa aattgtaata 1101781 atataaataa cacgagtgct gtaaaatcct taaatgataa ctgctatcag cgtaaaaaca 1101841 ggcagatatt atatgtaaaa agcaatatgg gcagaaaaca catgaaaaag tttttaatca 1101901 atttatgctt taaatggtag aaggatatta tgttcatgga agaaaaacta acgaagttta 1101961 aatattttaa attgataaaa taatattgca ataaattatt tgtttcatta taatgaactt 1102021 gttcactcta ttgttacagc ttttttacaa aaataatcag aaaagacgga acagaataaa 1102081 agttgtggaa actcaggttc atttgtctga tatttctgag gatttagccg taaggagctg 1102141 aaaattatta ttagggggtt tgcgaatatg aaaaaacgtt ggtcgattgt cacgttgatg 1102201 ctcattttca ctctcgtgct gagcgcgtgc ggctttggcg gcagcggatc aaacggtgaa 1102261 gggaaaaagg acagtaaagg aaagacgaca cttaacatta atattaaaac tgagccgttc 1102321 tccttacatc cgggattggc aaatgattca gtatcaggcg gtgttatccg tcagactttt 1102381 gaaggattga cacgtatcaa tgcagatggt gagcctgaag aaggcatggc ttctaaaatt 1102441 gaaacgagca aggacggaaa gacatataca tttaccattc gtgatggtgt gaaatggtct 1102501 aatggagacc ctgtaactgc acaagatttt gaatatgctt ggaaatgggc gcttgaccct 1102561 aataatgaat cacaatacgc ttaccagctc tactacataa aaggtgctga agcggcgaat 1102621 accggaaaag gcagcctaga cgatgtggca gtaaaagctg tgaatgacaa aacgctgaag 1102681 gttgaattaa ataacccgac tccatatttc actgaattaa ctgcgttcta tacgtatatg 1102741 ccgatcaata agaaaattgc agagaaaaat aaaaagtgga atacaaatgc cggagatgat 1102801 tatgtatcaa acgggccgtt caaaatgacg gcatggaaac acagcggctc tattactctc 1102861 gaaaaaaatg accagtattg ggataaagac aaagtcaaac tgaagaaaat cgatatggtt 1102921 atgatcaaca ataacaatac ggaactaaaa aaattccaag ctggcgaact tgattgggcc 1102981 ggtatgccgc tcggacagct tccgacagaa tccctgccga ccctgaaaaa agacggttct 1103041 ttacatgttg agccgattgc aggagtgtat tggtacaaat tcaacactga agctaagcca 1103101 ttagacaacg tcaatatccg taaagcttta acatattcgc ttgaccgtca gtcgattgtt 1103161 aaaaacgtta cgcaaggaga gcaaatcccg gcaatggctg cagtgccgcc tacaatgaag 1103221 ggatttgagg ataacaaaga aggatacttc aaagacaatg atgtcaaaac agcaaaagaa 1103281 taccttgaaa aaggcctaaa agaaatgggc ttaagcaagg catctgattt gccaaaaatc 1103341 aaattgtctt acaacactga tgacgcacac gcgaaaatcg ctcaagcagt acaagaaatg 1103401 tggaagaaaa atttaggcgt tgatgttgag cttgataact cagagtggaa tgtctatatt 1103461 gataagctcc acagccaaga ttatcaaatc ggccgtatgg gctggctcgg cgacttcaat 1103521 gatcctatca acttccttga attgttccgc gacaaaaacg gaggaaataa cgatacaggc 1103581 tgggaaaatc cagaattcaa aaagcttctg aatcagtcac aaactgaaac agataaaaca 1103641 aaacgtgcag agctgctgaa aaaagcagaa ggtattttca ttgatgaaat gccggttgcc 1103701 ccaatctatt tctatactga tacttgggta caggatgaaa acctaaaagg tgttatcatg 1103761 ccaggtactg gtgaggttta tttcagaaac gcatatttta aataaggcta cgtctgaaaa 1103821 taaaagacct caaggtatat ggggagaaaa gccccatata cctttcttac tgatggagta 1103881 taaaaatgta aaaaccatgg aggtgttccc ccttgctaaa atatatcgga agacgcttag 1103941 tctatatgat tatcacacta tttgtgattg taactgtgac attcttctta atgcaagcag 1104001 caccgggcgg gccattttca ggtgagaaaa agcttccgcc tgaaattgaa gcaaatttaa 1104061 atgcgcatta tggcttggac aagccgctgt ttgtacaata tgtcagttat ttgaaatcag 1104121 ttgcaatgtg ggatttcgga ccgtcattta aatataaagg tcagagtgtt aacgacctga 1104181 tcagttcagg tttccccgtt tcatttactc ttggagcaga agctattctc ctcgctttag 1104241 cgttaggtgt attgtttggg gtcattgcag ccctttacca taataagtgg caggattata 1104301 ccgtcgcgat tttaacgata tttggtattt cggttccgag ctttatcatg gcggctgttc 1104361 tgcaatatgt gttctccatg aagcttgggc tgtttccggt cgcggggtgg gattcctggg 1104421 catacacctt tttgccttcc atcgcacttg cttccatgcc gatggcgttt attgccagac 1104481 tttcccgttc aagcatgatc gaagtgttaa acagtgatta tatccgcaca gcgaaagcga 1104541 aagggctttc ccgcccagcg gttacagtgc ggcacgccat tcgaaacgca cttttgccgg 1104601 ttgttacata tatgggcccg atggccgcac aggtcttaac ggggagcttc attattgaaa 1104661 ccatttttgg gattccgggg cttggtgcac acttcgtcaa cagtattaca aaccgtgatt 1104721 atacggtcat tatgggtgta acggtgttct tcagtgtcat cttgctattg tgtgtattaa 1104781 tcgtagatgt gttatacggc attattgatc caagaatcaa gctttccaaa gcaaagaaag 1104841 gagcctaggc catgcagaac attccaaaaa acatgtttga accagccgca gcgaatgccg 1104901 gcgatgcaga aaaaataagt aaaaagagcc tttccctctg gaaagatgcg atgcttcgct 1104961 tccgcagcaa taagcttgca atggtcgggc ttatcattat cgtacttatt atccttatgg 1105021 caatttttgc gccgatgttc tcaaggtatg attattcaac tactaatctc ttaaatgcgg 1105081 ataagccgcc ttcaaaagat cactggttcg gaacagatga tcttggacgg gacattttcg 1105141 tccgtacatg ggtaggggcg cgaatctcaa tctttatcgg tgttgcagct gctgttctcg 1105201 atttgctgat cggcgtcatt tgggggagca tttcaggctt ccgcggagga agaacagatg 1105261 aaatcatgat gcgtatcgct gatatccttt gggcagttcc ttcattatta atggttatct 1105321 tactgatggt tgttcttccg aaaggtctat ttacgattat tattgccatg acgattacag 1105381 gctggattaa tatggccaga atcgtgcgcg gacaagtgct gcagctgaag aatcaggagt 1105441 atgtgcttgc ttcacagaca ctgggtgcaa aaacatcccg tcttctattt aaacatatcg 1105501 tgccaaacgc aatgggttct attttggtca cgatgacact gacagttcct actgcgattt 1105561 ttacagaagc ctttttaagc tatttgggac ttggtgttcc ggctccgctg gcaagctggg 1105621 gaacgatggc ttctgacgga ttgcctgcat tgacctatta tccgtggcgt ttattcttcc 1105681 ctgccggatt tatctgcatt acaatgtttg gttttaacgt tgtcggcgac ggattaagag 1105741 acgcattgga tcctaagtta cgtaaataag ggagtgatac gggtgacacg cctattagaa 1105801 gtaaaagatt tagcaatttc atttaaaaca tatggcggag aggtccaggc gatccgcgga 1105861 gtgaatttcc atctggataa aggggagacg ctggccattg ttggagaatc aggttccgga 1105921 aaaagtgtaa cctctcaagc gattatgaag ctgattccaa tgcctccggg ttatttcaaa 1105981 cgcggtgaga tcctgtttga aggaaaggat ctggtgccgc tgtccgaaaa agaaatgcaa 1106041 aatgtccggg gaaaagagat cggcatgata ttccaagatc cgatgacctc tttaaatcca 1106101 acgatgaagg tcggtaaaca aattacggaa gtgcttttta aacacgaaaa gatctcgaag 1106161 gaagcggcta aaaaacgcgc ggttgaactg ctggaattag tcggtatccc aatgccggaa 1106221 aagcgggtga accaatttcc gcatgaattt tcaggcggga tgagacagag ggttgtcatt 1106281 gccatggcgc ttgcagcgaa tccgaaactt ctgatcgccg atgagccgac aactgctctt 1106341 gatgtaacga ttcaagcgca aattttggaa ttaatgaagg atttgcaaaa gaaaattgac 1106401 acgtccatca tctttatcac acacgatctt ggtgttgtgg ctaacgttgc tgaccgggtc 1106461 gctgtcatgt acgcgggaca gattgtagaa actggtacgg tagacgaaat cttctacgac 1106521 ccgagacatc cgtacacttg ggggcttctt gcatccatgc cgacactgga aagttcagga 1106581 gaggaagagc tgactgcaat tccgggcacg ccgcctgatt tgacaaaccc gccaaaagga 1106641 gatgcttttg ccctgcggag ctcttacgcg atgaaaatcg attttgaaca ggagccgcca 1106701 atgtttaagg tatccgatac tcattatgta aaatcgtggc tgcttcatcc tgacgcgcca 1106761 aaggtagagc cgcctgaagc ggtaaaagcg aaaatgcgta aactggcaaa cacgtttgaa 1106821 aaacctgtct tagtgagaga agttgaatga attgactgaa aaactattag aaatcaaaca 1106881 tttaaaacag cactttgtca cgccgagggg aacggttaag gctgtagatg atttatcatt 1106941 tgatatctat aaaggtgaaa cattagggct ggttggtgaa tctggctgcg gtaaatcgac 1107001 aacaggccga agcattatca ggctgtacga agcaaccgat ggtgaggtgc tgttcaacgg 1107061 cgaaaatgtg cacgggagaa aatcgcggaa aaagctgctg gaattcaacc gcaaaatgca 1107121 gatgattttc caagacccct atgcatccct gaatccgaga atgacagttg ctgatattat 1107181 tgctgaaggc cttgatattc ataagctggc aaaaacgaaa aaagagcgga tgcagcgagt 1107241 tcatgaacta ttggaaacag tgggattgaa caaggaacac gcgaaccgct atcctcatga 1107301 attttccggc ggccagcgcc aaagaatcgg gattgccaga gcgcttgctg ttgatccgga 1107361 attcattatc gcggatgagc cgatttccgc tttggatgta tccattcaag cgcaggtcgt 1107421 gaatttaatg aaagaactgc aaaaagaaaa agggctcaca tacctgttta ttgcccacga 1107481 tttatcgatg gtcaaataca tcagtgaccg cattggcgtc atgtatttcg ggaaactggt 1107541 tgagcttgcg ccggcagatg agctttatga aaatccgctt cacccatata caaaatcatt 1107601 gctttctgcg attccgcttc ctgatccgga ctatgagaga aatcgcgttc gccagaaata 1107661 tgatccgtct gtccatcaat taaaggatgg ggaaacgatg gaattccgtg aagtcaaacc 1107721 gggacatttt gtgatgtgca cggaagccga atttaaagct ttttcatgat tcatcaatcc 1107781 ttcaagagat ttctcttgaa ggattttttt gcgtcttcat agaaagtgag aatgataaca 1107841 tttacaatta gaggaaaaag cggaggcgaa atacgattca atttctgcat aacaaaaatg 1107901 tttttgcgct attgctgtct caatcttttc aatctttagc aggagtcctc gtcacaatcg 1107961 ttttaatggt ccggatctat caaatgactg actccgtttt tttggcgggc cttattttat 1108021 cgttcatgtc gtttgcgagt atagcagcaa gcttttgcgt ctctccggtg cttcgcattc 1108081 tcggttttaa aaaggtgctt gcgggagcga atctgctgag agcggtcttt attatactga 1108141 tggcatacag cgtcactcat cacggacagg cattcttttg gattacgctg ctgtttgtgt 1108201 tttgtttttc cttcgcgggc gctttttttc agccggcaag atttgcgctg ctgccgatta 1108261 ttgttccaaa gaagcaatat gtaaaagcga atggtgtgat ctccctctcg aatcaattgt 1108321 tcttaacagc aggctggggc cttggaggcc ttctgacgta cgccgtccct tttgaactcg 1108381 ttgtcggcgc tgccatttgc ctgtttgttc tatcgggagc ttccatcagt gtgctgcatg 1108441 taaatgaaga agaggctgca ggaactgctg aaacagcatc tgtcagaagt atatggaagg 1108501 atttaatgat catccctatt gtaagagaca ttactgtaat ggacatgtta gaagctttgg 1108561 cgggttccgt atggtcatct gctattctcc tcgcatttac tgcggctgtt ttgcatgaaa 1108621 cagaggtgtg gtgggggatg tttaacgctt cctattttat aggcgcaatt gtcggcagtg 1108681 tgattgctat tcgtttttct tctttttttg agcggaatat gggctatgcc attatgttca 1108741 gctcgcttgt aatgtcggcg ctgacccttt tgttttcatt ttctccagtc ccatttttat 1108801 gcgctctggc ttgtgctgca atggggcctt tttatcaggt gcgtgatatt tgccaggaaa 1108861 ccatgctgca ggaagttatt cccgagcaga aacgaatcgg aatcatggct gcaaaaaatg 1108921 cgattttgac tccttggtca ggcgtcacct actccattat ggggctagtg gctgatgctg 1108981 ctggtgcgaa aatagctttt atcgcggctg ctgcattata tatcatgaca tttctgattg 1109041 cactggcgca gccccgtctg gttcattaca ggcgagaaaa tcgagttcaa tgagaaacac 1109101 ttcaaaatga acggagcagc tggctccgtt ttgctgaaaa aaaaatgaaa ccatggcgga 1109161 agttcgcacg tctttataga tgtaaggctg tttaaacaag aagaaatggg gtatatctaa 1109221 aagtatgaag acaacgaact cataaggagc aaatcaatga actggtatga aaagcttagc 1109281 gagtactttc caattgaaga aatgaaatca aaagcgcata tggaagctct tctgaaagag 1109341 cgaagcgata tttatcataa agatgaaggc aaacatcata ttttaatgtt tgcggaattc 1109401 gattctttta tcttcgttga ttatctgtat gtgtctaagg atgcaagagg gcaggggctt 1109461 ggcggcaaat tgatcgcgaa gctgaaaaag aaaaataagc ccatattgct cgaggtggaa 1109521 cctgtggatg aagatgatac tgatacagaa aaacgcctga ggttttatca aagagagcat 1109581 ttcaagcatg ctcagtcaat tgggtaccgg cgccggtcat tggctacgaa tgaagtaaac 1109641 aagatggaga ttctgtactg gtcaccaaaa acagaatcag aagaagaaat tcttgaagcc 1109701 atgaaacaga catatgaaaa cattcatact tataaagatg agaaatggta cggagaatcg 1109761 tacgaaaaaa cggatgaggt cttggaaatc atcgatgaag aaaaacaaaa aaatattttc 1109821 gatcagttaa gctaattgag aataagaaca tatcatgaac attaaaaatt tgctggattg 1109881 acacattttt ttcttaggat actgttcaca cttacttttt tatagtataa tacctgtaaa 1109941 gattcctttt ttagagtaat ttcaatttaa gaataaaata gatgttcatc ctactaatta 1110001 gaggagtgaa gatgaatggt tacactatac acatcaccaa gctgtacttc atgcagaaag 1110061 gcgagagcgt ggctcgagga gcacgagatt ccatttgtag aaagaaacat tttctctgaa 1110121 cctttatcaa ttgatgaaat aaaacaaatt cttcgaatga ctgaggacgg aacagatgaa 1110181 atcatctcaa cccgttcaaa agtattccaa aaactgaatg tgaacgttga atctatgccg 1110241 ctgcaagatt tgtaccgctt gatcaacgag catccaggtt tgcttcgccg tccgatcatc 1110301 attgacgaaa aacgtttgca ggtcggatat aacgaagacg aaatcagacg tttcctgcca 1110361 agaaaagttc gctctttcca attaagagaa gcacagcgtt tggcaaacta atagatcgta 1110421 tcatcaaaag aaggctgagt catcagcctt cttttatttt tcaacctgct ggtaataaat 1110481 gctcgcaagg atgacaaacg caaccgtcaa aatggggagg agcgtttcga ctgtgccgtg 1110541 ctgcgccata aaaagcgaca gctttttgtc tctgacaatc atttctccgc cagtataagc 1110601 aagcagcccg cttcccgcgt aaatcagaag cggtattttc tctagtgcaa tatggatgag 1110661 tttgctgccc caaataataa ccggaaccga tacacacaat cctataacaa cgagagaaaa 1110721 ctcaccgtgt gaagctcccg caactgcgat gacgttgtcc agcgacataa agagatctgc 1110781 aagcacaatc gttcgtatcg ctctccacag ggaggtgctg cttttaatgt gtttcgtgtc 1110841 ttttttttca atcagcagct gatatcctaa atacagcagg aaaattccgc cggcgcactg 1110901 caagaacgga atgttcaaaa gatatactgc tgcacttgtt aatccgattc tcatggcaac 1110961 ggcaataaat gttccgagaa taatggcttg ctgtctttgc ttgtccggca aatgtctgct 1111021 ggccatggca ataacaaccg cgttatctcc gccgaggatc aggtcaatcc caacaatgac 1111081 gagcagagaa atcagatagt catgctccat gaagcggcac ctcgctttca gtccttcgct 1111141 tgtactacta ctatatgaga caggtcatat tttatgatat cagccgcctg atctgccgtt 1111201 ttttaggcaa aggtgcattt ttatttcttt tgtgactgtt ttatcataaa atagaaatac 1111261 aaaggaattc acactggcct tggttaaggt taagatgtgg acggaatggg taaagtgtag 1111321 taaagtacaa ttaatcggga gcttagatgt cccttcaaca tcttatatag aagggaaggt 1111381 tggcaaatgg aaattgaaag aattaacgag catacagtaa aattttatat gtcttacgga 1111441 gatattgaag atcgcggttt tgacagagaa gaaatttggt ataaccgtga gcgcagtgaa 1111501 gaacttttct gggaagtcat ggatgaagtt catgaagaag aggaattcgc tgtggaaggc 1111561 ccactttgga ttcaagttca ggcactggac aaaggattag aaatcatcgt cacaaaagcc 1111621 cagctttcca aagacggaca aaagctcgaa ctgccgattc ctgaggataa aaagcaagaa 1111681 ccagcatctg aggatcttga cgccttgctg gatgatttcc agaaagaaga gcaagccgtc 1111741 aatcaggaag agaaggagca aaagcttcaa tttgtcttgc gatttggcga ttttgaggat 1111801 gttatttctc tatctaaatt gaacgttaac ggaagcaaaa cgactttata ttcgtttgag 1111861 aaccgatatt atttatatgt agatttttgc aatatgactg atgaagaggt tgaaaatcag 1111921 ctaagcatcc tgctggagta cgcaactgaa tcctcaatca gcatacaccg tcttgaagag 1111981 tacggcaagc tgattatttc agagcatgct ctagaaacga taaaaaaaca ctttgcatca 1112041 tagcaaaccg atttccttcc ggaaatcggt tttttttatg cacgaaaatg ccattttaga 1112101 gatgtgaaaa atcaaaaaca tatagacaag cagaaaatac agcgaacagg agttgatcat 1112161 cttttccaga aagtatactt catctggaaa ggagagatga caattgttta gtgctgtgac 1112221 tgaagacggc caaatgtttc accttctagg cgctcagcaa aaccagaaat taaagcggag 1112281 acggttcttc tgtccggtat gcgggggaga gctagctgtg aagctcggac ttcaaaaagc 1112341 gccgcatttt gcccataaac agaacaagtc ctgcgccata gacatcgagc cggaaagcgc 1112401 ctaccactta gaaggaaaaa gacagctgta tgtatggctg aaaacgcaac gggcttcacc 1112461 aatattggag ccgtatataa ggacaatcaa ccaaagaccg gacgtcatgg caagaatcaa 1112521 ggagcatatg cttgctgttg aatatcaatg cgccactatc gctccagatg tctttcaaaa 1112581 gcggacagag ggcttcaaac aagaaggaat catcccgcag tggattatgg gatacagccg 1112641 cttaaaacgg actgcttcgt ccttttatca gctttcaact tttcattggc agtttatcaa 1112701 tgcaagtcca tacagagaac tgatatgtta ttgtcctgaa aggcgttctt ttctccggct 1112761 cagccacatc attccattct acacaaacca ttcttattcc tcagtccaaa cgatccctat 1112821 ccatcgggca ggtgcaggcg atcttttttt cactgaaccg aaaccctcaa ttcaatattc 1112881 aggctggacg aaagcgattc accgttttcg ccataaaccc catcggttta actcaaagga 1112941 aacaaatcgc cttaggctgc tgttttatga gaaacgacag acgccttttt cttttctgcc 1113001 gactgaagtg tttgttcctg ttagaaaagg ggcagttttt aagagtccgg tttttgtgtg 1113061 gcaggggttt ctttatttgt ttatgacgga tcttggaggt aaacgtgcgc caattcgttt 1113121 ttcagccgtt ttgcagcagt gcaaactgca cattcataat aagaacattg cactcaggtc 1113181 cgaatgcagc gaagagtgtc tttcagaagc ggttaaacag tatattgatt ttttgtgcaa 1113241 gaagggattt ttaagggaga ctcagaaaga agtatatgtg ctgaatcagc ctgcaggagg 1113301 catacactcc atgcaggatc tcatagaaag agaccgcagc tgttttatag aatgagtttg 1113361 tcttatttgg ctcaccctaa gacaaaggtg gtgggcaggc tgtgaaaggc acaaaaggaa 1113421 aggtttttcg tgtttttact gcttttttgg cattcgttct cttcattact gcatatgatt 1113481 tgacaaaagg cagtgaaaaa ccggaagata ttcacaacac aagtttattg agaaacagct 1113541 gttttttcaa ttggcttgaa tcaaagaaga cgagggggat caccatggct gaggaaaaaa 1113601 aagcaaacca actgcctgac agaagtgagg taaaggcaga agacacatgg agacttgagg 1113661 atatttttcc tagtgatgag gcctggaata aagaatttca agctgtaaaa gaattaattc 1113721 cgaatttatc taagtataaa ggaaagctgg cagattcagc tgatcattta tacgaggctc 1113781 ttacgtatca agataaagtg atggagcggc taggtaggct gtacacatat gcgcatatgc 1113841 gctctgacca ggatactggg aactcctttt accaggggct gaatgacaag gcgggaaacc 1113901 tgtatacaca ggccgcaagc gcgacagctt atttggttcc ggagatttta tccatagaag 1113961 aagacaaact gcagcagttc attcttgaaa aagaagaatt gaagctgtac tctcatgcga 1114021 ttgaggagat tacaaaggaa cgtccgcatg tgctgagcga gaaggaagag gcgctgcttg 1114081 ctgaagcctc cgaggtactg gggtcatctt caaatacatt cagcgtgtta aataacgcag 1114141 atataacgtt tccatccatt aaagacgaag atgggaatga aaaacagatc actcacggca 1114201 actttattaa tttcttggaa agtgaaaacc gtgaagtccg caaaaatgcg tttgacgcag 1114261 tgtataaaac gtacggacaa tataaaaaca caatggccac gacgctaagc ggcactgtga 1114321 aaaaggacaa cttctacgcg agagtgaaaa agtacaagtc cgcgcgtgag gctgcgcttt 1114381 ctaacaacag tattcctgag gaagtatacg ataaccttgt taagacgatt aataagcatt 1114441 tgccgctcct gcaccgctat attgcgctaa gaaagaaagt gcttgagctt gatgaagtgc 1114501 atatctatga cctgtataca ccgcttgtga aagatgctgg gatgaaggtg acatacgagg 1114561 aagccaaaga ttacatgctg aaaggcctcg cacctttagg ggaagaatat gcctctatcc 1114621 taaaagaagg actggaaaac cgctgggtgg acgtttacga aaataaaggc aaacgcaatg 1114681 gggcttattc atcaggagct tacggcacga atccgtatat tttgatgaac tggcataata 1114741 acgtcaataa tctctttacg ctcgtgcacg agtttggaca ttccgtacac agctactata 1114801 cgagaaagca ccagccttat ccatacggca attacagcat ctttgtcgcg gaagttgcct 1114861 ctacgacaaa tgaagcgctc cttggcgaat atttgctgaa caatttagag gatgaaaaac 1114921 agcgcttata tattctcaac catatgcttg agggcttcag gggaacggtc ttcagacaaa 1114981 cgatgttcgc tgaatttgaa catctgattc atacaaaggc gcaagaaggc gagccgctta 1115041 cacctgagct tctgacaaat gtctattacg acctgaataa aaagtatttt ggagacggca 1115101 tggtgattga taaggaaatc ggccttgaat ggtcgcgtat tccgcacttc tattacaatt 1115161 actatgtgta tcagtatgcg acaggttaca gcgctgccca agcattaagc agccagattt 1115221 tgaaggaagg aaagccggcg gttgaccgtt atattgactt cctgaaagcg ggaagctcac 1115281 aatacccgat tgatgtcctg aaaaaagcgg gtgttgatat gacgtctcca gagccaatcg 1115341 aagccgcgtg caaaatgttt gaagaaaaac ttgatgaaat ggaagagctg ctgatgaaag 1115401 tcaagcagtc ttaaaaaagt aagcctgtgc ggaaatgacg cacaggcttt tttaaaaccc 1115461 tttaaaggtt ttccggtgat tcaagcggta gagggtaaac aaaatagaca gaaacagcag 1115521 aggagaggta atataaagcg gcagcatatg catcatgcct aagatattca agcagaaaaa 1115581 aacagcaatg cacacaattg agatcaaagt agacatcatg gcggtcctcc tcgtcctttt 1115641 tccttataag gatatgagtg aatgcacttc gttatgtttt gtgacaaaaa tatgaacatt 1115701 aagcatagag gttgtcaaaa gtcgacatct tttgttatca taaggatgtg aaattgatca 1115761 caaacaaaca ttaccccttt gtttgaccgt gaaaaatttc tcccatcccc tttgttgtcg 1115821 ttaagacata tgaaaccgcg cttatcccgg cgcggtttct ttagtgctaa aaatggaacg 1115881 tacgtttggt tatggcataa aaaaacagcc tcaagcatat gcacgcctgc ggctattttt 1115941 cacatgattg atattcatca gaataagtgc tgagagactt ccaaaacatt ccgtgtttgg 1116001 cttccacttt ggcaaccttt ttagcaaacg ccagtttttt catttctttt tctacctctt 1116061 caaggctcag gtcatataca agagcaattt ccttcgaggc aacgaagcgg aaatattcaa 1116121 taaaacattc taaaggcggt gtttccgacg gcttcggctc gtcgccaagc atctcaaata 1116181 aaatttcttc atatacatca tatgagtagc tgccaggaac tttaagccct tcatcctcat 1116241 gctgcgtatt aaaaaacgtc agtgtcggat taacagaaac atccatctcg gcagcaattt 1116301 tcatgtcaca ttgaagcgcc ttgaccgcgc tttgagaatg cagatctttt ttgaattctt 1116361 caagatcgag acttgtattt tcagcaatct ccaaaagcac gttttcatcc gtaatatttt 1116421 tctttgaaac aaataggctc tcctgcatat ttctgagaaa ttgcatgccg gcttttcgtc 1116481 cttgcagttc ggctgcttta aaagcgagag cagccatata aggcgatgaa agcggctgat 1116541 cctgttcgaa ccagacattg ccgtcacatg acatgccaga gcggctcgcg atcttttccc 1116601 atgcttctgc gagaagatgc ttttttcgct ttttatttaa agcggtaagg cttgcggaag 1116661 cgataatgcg taaggtgaaa aaacgtccgt atctgatttt cagctttttg atgacgggct 1116721 ctaaggacca gcattcagga cataaagggt ctacaaacat ataaatttca agcggttttt 1116781 ttggatgacc gtggcaatgg gcgaagtata gctcatgctg atagtttgtc aagatgatcg 1116841 atcctccgct tccgtttgat tcaccatatg ccttgctgtc aactccagcc ggccaaacaa 1116901 aaactcacga atttcgccct ccagccctac atggtccatt gcgtccttca tacagctgag 1116961 ccacgcatca gctctctcgt ttgtaattgg aaagggaaga tgccttgctc tgagcatagg 1117021 atggccgtgt tcctcagtat aaagaggagg cccgcctaaa tactgagtta agaattgctt 1117081 ctgtttcctg gcggtttctg tcaaatcgct tggaaaaatc ggcttcagca aaggatgaga 1117141 cgcgacacgc tcataaaaag tatcaacaag ttgcgataga agttcctctc caatcgcttc 1117201 ataaggtgcg ttaaacgatt gtcccatgtt gactactcct ttaaatatgg ctaataggaa 1117261 tcataaatcc tattgcaaaa agtaattttc tgtatttcat tgtttcatct agatttattt 1117321 tagcaacaag gcatcatttc tacaaacaaa ctgcctttta tgcgtttgat gactcatttc 1117381 ggctgacagc cggggtttgt atttcatatc atatcacata aaaatcagga atgcgtaaga 1117441 tttcacttcg caaaaaaacc agagggaaag agcacctctg gttacgcgta ataaactgaa 1117501 gttatttttt ttacatagtt ttgcgtttct tggaaaggag gaatgcctcc gtatcggtca 1117561 acattccccg gtccggcgtt gtaagccgct aatgccatag acacattgcc gtcgtattta 1117621 tccagcattt gttttaaata tttcgttccg ccctccacat tttgctgcgg atcaagcgga 1117681 ttggaaacgc caagtgagct tgctgttgac ggcatcagct gcatgaggcc catcgcacct 1117741 gctccgctga ccgcttttgc attaaagcct gattcctgtt tgatgacggc gcggatcagt 1117801 ttttcatcaa cgccatattt atcagcggct tttttaatcg cactgtcaat agagaagtct 1117861 cccgaacgga tctgatttgc ttcatgtttg tttgaagctg aatctgcaac agctgtttca 1117921 gtgctttctg ccgcttttgt gactgaacct gaattgctgc tcgtatatga gttaagccca 1117981 tacgctgaaa gcagtgacgg cgctgttgta ttcgcgctgt tcagcatgct gagcgggctt 1118041 ggcgatgaag aaggtgctga ttgctgagat gtcagaccgt ttgtatattg gctgagcaaa 1118101 gaactgaaac ttgaaagcgg gctttccgta ttctgagtgt ccgagctgct gcgtgcatta 1118161 gatatggact gtaatgcctg aagctgaagt aatgctgccc aattcgttac attcacgatg 1118221 tcattccacc ttatatagac tttcgttttt cttcataaaa acgcagaatt ttatttttgg 1118281 tttcgcgctg aggaatgctg aattgctgaa gcagcttttc gaaggcttgt ctgccctcat 1118341 gccaatccgc cgcctcaaat tcaatttcat agtcctcttt atttaaatat cggctgtggt 1118401 ctaaaactat taagcctttt tctgtttctt tttccgcacg gtttgttgct aaagatccaa 1118461 agtattgtat ggcatccgta tcgatctgaa gcttgtgcag ctggtccttc acagggccct 1118521 cgggaactga aaatccagcg agatctgata cctctgaaag ctgctggtgc gtttccagaa 1118581 gccccacatc agccggctcc tttaatgtaa ggacatactt tccgtttttt ctgcggatac 1118641 gaagcgcagc atgtttttgt ttcagcgcga agctgtctgt atcaaaataa tgattctttt 1118701 gatctgtaaa atctttttct gtcagctgga gtgccgatgc tatgtttttg aattcttgtt 1118761 tggtcagcat gtttttaaat tcgatttcaa tctcttggct catgatgctc ttcctttccg 1118821 ccctgtaaat cttattttta ctattatctc tttagatgtt aggtttatca atatcgagct 1118881 cgatatgata aaatgaatct gtactttgtt taaaaaagga gagcattatg caaaacagaa 1118941 tcgaaatttt gaatgcaaca ttatcggatg atcagcttcg ccttgcctgt cagacagaag 1119001 gaaacgaagc ggaacgcaag ccgtcaggtc aaatgcttgt tgattctgac cactttgctt 1119061 ttgtatacat acttgaatta gctgattctt ttgaatatgt cattataaag gaacatgtat 1119121 ggccggaact gaagcaggcc catgcacaaa aaataccggt tgttttagag gcaggagacc 1119181 aaacaattga actggcaggc ctgcatgagg agctggaata tcttttagaa aatataaaag 1119241 ataatgcaaa ctatggagaa gaaatggaag aaaaagtgaa acgcgtgttt ttatagaaac 1119301 tggttcggaa ttgggggatg tatgatggat gacaaacaat gggagcgttt tttagtgccg 1119361 taccgccagg ctgtcgaaga gttgaaagtg aagctcaagg ggatccgcac actatatgaa 1119421 tacgaggacg accattcacc gatcgaattt gtgaccggac gcgtcaagcc tgtggcgagc 1119481 atacttgaaa aagcgagacg gaaaagcata ccgctgcatg aaattgaaac catgcaggac 1119541 attgctggcc ttagaatcat gtgccaattt gtcgatgaca tccaaatcgt aaaagagatg 1119601 ctttttgcca gaaaagattt caccgttgtg gatcagaggg attatattgc ggaacataaa 1119661 gagagcggat accgatcata ccatcttgtt gtgctgtacc ctttgcagac ggtatccgga 1119721 gaaaagcatg ttctcgtaga aatacagatc cgtacactgg cgatgaattt ttgggcgacc 1119781 attgaacatt cattgaatta taaatacagc ggaaacattc ctgaaaaagt aaaactaagg 1119841 cttcagcgcg cttctgaagc ggcttcccgg cttgatgaag agatgtcgga gatcaggggt 1119901 gaagtacagg aagctcaagc tgccttttca agaaagaaaa aaggaagcga gcaacaatag 1119961 gtaaagggga agaagagcat gaaatttgcc gtatcatcaa aaggagatca agtttctgat 1120021 acgctgaaaa gcaaaataca ggcgtattta ttggattttg atatggaact ggatgaaaat 1120081 gaaccggaaa tcgttatttc agtcggaggc gacggaacgc ttttgtatgc ttttcacaga 1120141 tacagcgacc gtttggacaa aacagcattt gtcggcgttc acacaggtca tctgggtttt 1120201 tatgccgact gggttcctca tgaaattgaa aaacttgttc ttgccatcgc gaaaacgccg 1120261 tatcatacag tcgaatatcc gcttctcgaa gtcattgtga cctatcacga aaacgagcgg 1120321 gaagaaagat acttagcttt gaatgaatgt acgattaaaa gcatcgaagg aagccttgtt 1120381 gctgatgtgg aaatcaaagg gcagctcttt gaaaccttcc ggggcgacgg cctctgcctg 1120441 tcaactccat caggcagcac agcctacaat aaggcgctgg gcggagcgat tatccatccg 1120501 tctatcaggg cgatccagct tgcggaaatg gcttcaatta ataaccgcgt gttccgtacg 1120561 gtcgggtcac ctctgcttct cccatcccat catgattgca tgattaagcc gagaaacgaa 1120621 gttgactttc aagtgacgat tgaccattta acccttctcc ataaggatgt aaagtcgatc 1120681 cgctgccaag ttgcatccga aaaagtgcgg tttgcgagat tccgtccgtt tccattttgg 1120741 aaaagagtcc aggattcgtt tattggaaaa ggtgaataga aagaggacat atcgtggagc 1120801 atttttttat cagaaagaac attacttccg ctgaggacgg gatgactgta aaagaatatg 1120861 ccggtgaact gggaatttcg aaacgtctgc tgaccgatat taagtttggc gggggagacc 1120921 tgcagattaa cggtgagcat gtgacggtca aatacgtttt gaaagaggga gatcttctta 1120981 tcgtgaagtt tcctgaggag caggtgagcg agacgctgtt ggcagagcct gttccgctcg 1121041 atatccttta tgaggatgaa catgtgcttg tgataaacaa gcagccgtat gtgtcatcaa 1121101 tcccttcgag agagcacccc tccggcagca ttgccaatgg aattattgat cattatcaaa 1121161 caaccggagt gagggcgaca gttcatcttg tcacccggtt agaccgggat acatcaggta 1121221 tcatgcttgt tgccaagcat cgatttgccc actccatttt atcgtctgcg caaaaaaacg 1121281 gccttgtgaa acgccggtat gcggcagtgg ttcacgggcg gatggcacag atggagggaa 1121341 cagtcgatgc tccgattggc agacatcctg acagtattat tgaacggacg gtaacgccag 1121401 acggccagaa ggctgttact catttttacg tcacatgtgc aaatgatgac atgacctcgg 1121461 tggcattgca gcttgagact ggacgaaccc atcaaattcg tgttcatatg agctatctcg 1121521 ggcacccgtt gtgcggcgat acactgtacg gcggaacgag acaggaaatt ggccggcagg 1121581 ctctgcacag cgagcatctt tcgtttatcc atccgctgac acaggagaac atgaggtttc 1121641 atgctccact gcctcaggac atgagcaaac tgataaaagg agagaatcat tgattctctc 1121701 cttttttata tggggcgaaa tcttgattcg tcgtaaggca gggagcttgg aacagagacg 1121761 gtttctattt ctggaaagcg aaagcctgtc agttgatttc cgaacacgca gcctgtatca 1121821 atgttgatgg tgcgattgac cttccgaggc tctttcacag gtgtatgacc gtataccacc 1121881 caagcctttc cgttataggc tgccgcccaa tcacgcctga tgggtctgcc gtccggatat 1121941 gtttcacccg tcacgtcacc gtaaagcaca aagtccttca ctctgcgggt atatttgccg 1122001 atatcgtcag ctcttatgcc agcatgggcg acaactaatt ctccattatg taagatgtcg 1122061 taaagcggcg ctgtttcgta cagcttcata aactgttcgc tgactgattt tttctcatct 1122121 ttggaaagtt cctcaagctc tgccgctgtt gtttcgagac catgcatcac ttttaccgga 1122181 tttcctttta agtaacgata taatttattg caatggtttc ccgggacata acgcacagcg 1122241 cctttttcgt aagcgccggc tacaaatcgg atgacctcta tcgatttggg ccctctgtca 1122301 gttaaatctc cggcaaaaac aagcaccctg ccttcttcat ggacaggtac tccatttttg 1122361 attgtatagc caagcttttg gattaatgca gtcatttcgt catagcagcc atgaatatcg 1122421 ctgatgatat cgtaagccat gcggtctcct ccttaccgat tgttttattt attatgaagc 1122481 aaagtgttgt gagtcatcac aagcttttat gtgcaaatta tagaagaaga atcattttct 1122541 aaacaggatt aagaccttat cactttattt ttcatcatca cccttgttaa aatcgcgtta 1122601 tgttttttaa aaatgaggtt ttgttctctg agtgagaact agcataaccc tgacttaaaa 1122661 aggaggttct gattatggcg catacatctg tcgcatcttt agttgttgta cttatcgttg 1122721 catttttgac acccatcctt ttgcatcggt ttaaactcag catcccggtt gttgttgctg 1122781 aaatcattat ggggctgata attgggaaaa gcggccttaa tttagttgtg gagggtgaca 1122841 cctggctcca gacactctct atgctcggat ttatcttttt aatgttttta agcgggcttg 1122901 aaattgattt ttcgtcgttt gagaaaggaa agaaaaagca gttcctgccg aatggcaagg 1122961 aagcgccgaa tacgtttgct gcggcatctg ttattttcgt cggtattttt attttatcat 1123021 tgctcttgtc ctatgggttc gtcttggccg gatttatcca aaatgcattt ttgatgaccc 1123081 tgattatttc aacgatttca ttaggcgttg tcgttccaac attaaaagaa gaacggatca 1123141 tgaattcgaa tatcgggcag attattttgc ttgttgctgt tattgctgat ttggccacga 1123201 tgattcttct tgctgttttt tcttctttat acggagagga cagcggaaac atgtggctcc 1123261 tgatgattct gtttgcggcc ggagtggtgc tttacttttt cggccgggtc ttcaaacatc 1123321 gctcttttgt tcaatccatg tcaaaaggga cgatccagat cgggacgcgt gccattttta 1123381 cgttaatcat tgtactcgtt gccctgtctg aatcacttgg ggcggaaaat attctcggcg 1123441 ctttcttagc gggggttctt gtttccctgc tttcgccaaa caaagaactt gttcagcagc 1123501 tggactcatt cggttatggg ttcttaatac cgattttctt cgtgatggtc ggtgtgaagc 1123561 ttgatatttg gactcttttc caggataaaa caattttaat catgattccg ctcctgctgc 1123621 ttgcgctgtt agtcagcaaa atcattcctg tcatgtactt aaagaagtgg tatgataacc 1123681 gaaccatttt cgcgtctggt ttcctgctga catcaacgct ttcgctcgtg attgctgctg 1123741 caacaatcgg ccagcagctt cacgtgatca gtacaaatat gtcaggagcg ctaattttag 1123801 tagccgtcat tgcaagtatt tttacgccga tctgttttaa aaaattatac aaacgggaag 1123861 agcagccgga ggagaaaaag acgattacgt tcattggcgc caatcaaatg actttgcctg 1123921 tcacactcga attgccagag gaagagtatg acgtgcgtgt tgtacacgtc taccaagaga 1123981 atgcggagga aaagctgtca gaatcagtgt ttgctgttga aacaatttct gactatgaac 1124041 acgagacgct tgaatcactc ggcatttttg aaacggatat cctcgttgtg gcgacaggaa 1124101 atgaagatat gaatgcagac attgcattac ttgcaaaaga taaaggcaca gaaagagtca 1124161 ttgcaagcgt aggatcaccg gagcatgaag cagctctgaa ggagcaggga atcagcatct 1124221 tttctattct gctgtcgaca aaaacgctgc ttcgcgcact gattgaagcg cctggcgtca 1124281 tgaagctgct cacgaaccaa gagtcttcgc tgtatcaaat taatatggag aacagtaaat 1124341 atgatggtgt cattttacgg gaattccctt taacaggtga cgtcatcttt gtcaggatct 1124401 tcagaggtgt ggacagcatc gttcctcatg gggatacgag gctgaaactt ggagaccgtt 1124461 taattgtcac cggatctcgg gggtacgtaa cggatcttaa gaaaacattg gaaggataaa 1124521 tcttgaccaa ataaggattc gtgttaatat agaggtgcag aacaattcaa tatgtattcg 1124581 tttaaccact aggggtgtcc ttcataaggg ctgagataaa agtgtgactt ttagaccctc 1124641 ataacttgaa caggttcaga cctgcgtagg gaagtggagc ggtatttgtg ttattttact 1124701 atgccaattc caaaccactt ttccttgcgg gaaagtggtt tttttatttt cagaggggga 1124761 atgatttgtg aagttttcag aagaatgccg cagtgcagcc gcagaatggt gggaggggag 1124821 ctttgtccat ccgttcgttc aaggaatcgg tgacggaacg cttccgattg accgttttaa 1124881 atactacgta cttcaggatt cctattattt aacgcatttt gcaaaggtgc agtcatttgg 1124941 tgccgcttat gcgaaggatc tttatacaac ggggcggatg gcaagccatg cccaaggtac 1125001 atatgaggcg gaaatggcgc ttcatcgcga gtttgccgag ctgttggaaa tcagcgagga 1125061 agagcgtaag gcgtttaagc cgtctcctac ggcgtactct tatacatccc atatgtaccg 1125121 ttcggttttg agcgggaatt tcgcagaaat cttagcggcc ctgctgccat gctattggct 1125181 ctattacgag gttggtgaga aattgctgca ttgtgatccg gggcatccaa tttatcagaa 1125241 gtggattggc acatatggcg gtgattggtt tagacaacag gtcgaggagc aaatcaaccg 1125301 ctttgatgag ctggcggaaa acagcacgga ggaagtgcgt gccaagatga aagagaattt 1125361 tgtcatctcc agctactatg aatatcaatt ttggggaatg gcctatcgaa aagaaggctg 1125421 gtctgacagc gccataaaag aggtggagga atgtggagct tcacgccata acggatgaca 1125481 gcaagccggt agaagagcta gcgagaatca tcattacgat tcagaatgaa gttgatttta 1125541 ttcacattcg ggaacgctca aaatcggcgg cggatatttt gaaactgctc gatcttattt 1125601 ttgaaggcgg tatagataaa cgaaaattgg tgatgaacgg gcgcgtggat attgcacttt 1125661 tctctactat tcaccgcgtg cagctgccaa gcggcagctt ttcaccgaag cagatcagag 1125721 ccagatttcc acaccttcat atcgggaggt cggtgcattc actggaggaa gcggttcaag 1125781 cagaaaagga agacgcggac tacgtgctgt tcggccatgt gtttgaaacg gattgcaaaa 1125841 agggtcttga aggcagagga gtatctttgc tgtcagatat caaacagcgg atttccatcc 1125901 cggttatagc catcgggggg atgacgccgg acaggttaag agacgtaaaa caagcagggg 1125961 cagacggcat tgctgttatg tcaggaattt tctcttccgc tgaacctttg gaagcagcca 1126021 gacgatattc ccgcaagcta aaggagatgc gctatgaaaa ggcattatga agcagtggtg 1126081 attggaggcg gaattatcgg ttccgcaatt gcttattatt tggcaaagga aaacaaaaac 1126141 accgcattgt ttgaaagcgg aacaatgggc ggcagaacga caagtgccgc tgccggaatg 1126201 ctgggcgccc atgccgaatg cgaggaacgt gacgcgtttt ttgatttcgc tatgcacagt 1126261 cagcgtctgt acaaaggtct tggagaagag ctttatgcat tatccggtgt ggatatcagg 1126321 cagcataacg gcggtatgtt taagcttgca ttttctgaag aagatgtgct gcagctgaga 1126381 cagatggacg atttggactc tgtcagctgg tattcaaaag aagaggtgtt agaaaaagag 1126441 ccgtatgcgt ctggtgacat ctttggtgca tcttttattc aggatgatgt gcatgtggag 1126501 ccttattttg tttgcaaggc atatgtgaaa gcagcaaaaa tgcttggggc ggagattttt 1126561 gagcatacgc ccgtcctgca tgtcgaacgt gacggtgaag ccctgttcat caagacccct 1126621 agcggagacg tatgggctaa tcatgttgtc gttgccagcg gggtgtggag cggaatgttt 1126681 tttaaacagc ttggactgaa caatgctttt ctccctgtaa aaggggagtg cctgtccgtt 1126741 tggaatgatg atatcccgct gacaaaaacg ctttaccatg atcactgcta tatcgtaccg 1126801 agaaaaagcg gaagactggt tgtcggcgcg acaatgaagc cgggggactg gagtgaaaca 1126861 ccggatcttg gcggattgga atctgttatg aaaaaagcaa aaacgatgct gccggctata 1126921 cagaatatga aggtggatcg tttttgggcg ggactccgtc cgggaacaaa ggatggaaaa 1126981 ccgtacatcg gcagacatcc tgaggacagc cgtattttat ttgcggctgg ccatttcaga 1127041 aacgggatcc tgcttgctcc cgcaacgggc gctttgatca gtgatctcat catgaataaa 1127101 gaggtcaacc aagactggct gcacgcattc cgaattgatc gcaaggaggc ggttcagata 1127161 tgatgctaca gctgaacggt aaagacgtga agtggaaaaa agacacaggt acaattcaag 1127221 acctgctggc gtcgtatcag cttgaaaata aaatcgttat cgtggaaaga aataaagaaa 1127281 taatcgggaa agaacgctat cacgaggttg agctttgtga tcgtgatgtc attgaaattg 1127341 tccattttgt aggaggcgga tgagcatgtt aacaattggc ggaaaatcat ttcaatcaag 1127401 attgctgctg ggcacgggga aatacccatc gtttgacatt caaaaggaag cagtagctgt 1127461 ttctgagtct gatattttaa catttgctgt aaggagaatg aacatttttg aagcatctca 1127521 gccgaatttt ctggaacagc ttgatttatc caaatatacg cttttgccga atacagcggg 1127581 cgccagtact gctgaagaag cggttcggat tgcaaggctg gcgaaagctt caggcctttg 1127641 tgacatgatt aaagttgaag tcatcggatg cagccgttcc ttgctgcctg accctgttga 1127701 gacattaaaa gcgtctgaac agcttcttga agaaggcttt attgtgctcc cgtacacgtc 1127761 ggatgacgtt gtgctggcga gaaagctgga agagctcggc gttcatgcca tcatgccggg 1127821 tgcatctccg attggatcag gacaaggaat cttaaatcct ttgaatctgt cgtttattat 1127881 tgaacaggcg aaagtaccgg tcatcgtgga tgcgggaatc ggctcgccta aagatgcggc 1127941 atacgcaatg gagcttggag cggatggcgt actgctcaat acggctgtat ctggcgctga 1128001 cgatcccgtg aaaatggctc gtgccatgaa gctcgcagtg gaagcagggc gcctttctta 1128061 tgaggcgggc cgaatcccgc ttaagcaata cggaacggca agcagtccgg gagaaggtct 1128121 tcctgtatga caggcaggta ttcaaggcag gagctgtttg ctccgatcgg cccatccggc 1128181 cagaaaaaat tgaaagaagc gcgcgccgtg attatcggcg ccggcgcgct cggaacagcc 1128241 agtgcagaaa tgctggtgag agcgggagtc ggctctgtga aaattgccga cagagattat 1128301 gttgaatgga gcaacctcca gcgccagcag ctttatacag aagatgatgt caaaaaagaa 1128361 atgccgaaag cagccgctgc ggagcgccgt ctccgttcga ttaacagcga tgttgatgtg 1128421 accggccttg tcatggatgt gacagcagaa aatatcttcg agctgattag ggatgcatcg 1128481 attattgtgg atgcggctga taattttgaa acccgcctga tcgtaaatga tgctgcggta 1128541 aaggaaggga ttccttttct ttacggtgcc tgtgtaggga gctacggtct tacctttacc 1128601 gtggtgccgg gttctactcc ttgcctgcat tgcttgctcg atgcacttcc gattggcgga 1128661 gcaacatgtg acacagctgg catcatcagt ccggctgttt tgcaggtagc agtctttcag 1128721 gtaacagatg cactgaaact gctgacggga gaggagtgcg agccggtgct gcgctccttt 1128781 gatttgtgga aaaacgagcg gtcagaagtg agagcggcca gtctcaaaca tgacgcatgc 1128841 ccaagctgcg gcacaaagga ttttccgttt ttgtcttatg aaaatcaaac aaaagcggct 1128901 gtattgtgcg gcaggaacac ggtgcagatc agatcatcta ttacgaaaga agcggatctt 1128961 gaagcgcttg ccggtcagct gaggcaggcc gggcttgaag tagctgcgaa cccgtattta 1129021 atttcctgcc gctcggatga tatgaaaatg gtgctgttcc gggacggcag agctttgatc 1129081 catggaacaa atgatattgc ccgggcaaaa tccatttatc ataaatggat tgggtaataa 1129141 aaggagtgta gtgtaatgag tatatataaa gcattgacaa tcgccggatc agattcaggc 1129201 ggcggcgcag ggatacaggc tgatattaaa acctttcaag agcttgatgt attcggaatg 1129261 tctgcgatta cggcggtaac cgctcaaaat acgcttggcg ttcacggggt gcatccgctg 1129321 actgtagaga cgttgagaca gcaaattgac gctgttgctg aggatttgag accggatgca 1129381 gttaagacgg gaatgctctg gaatgccgac atgattgaag aagtggcaag aaaaattgac 1129441 gagtacggat tcaatcgtgt aattgttgat ccggttatga tcgcaaaggg cggggcatcc 1129501 ttgctgcgtg atgagtcagt tgccacctta aaggagttgc tcattccaag aagctacgcg 1129561 attacgccga atgtcccgga agcagaaacg ctgacaggaa tgacaatcag ctcgctggat 1129621 gaccggaaaa aagcagcgga gcagctcgtc aagatgggtg cgcagcatgt cattatcaaa 1129681 ggcgggcacc agcctgagga caatcacatt actgaccttc tttttgatgg cagcatgttt 1129741 atgcaaatca cccatcctta tatcaatacg aagcatacgc atggcacagg ctgcaccttt 1129801 gctgcggctt taacggccca aacggctaaa ggagacagca tccatcaggc atttgaggtt 1129861 gcggccaact ttgtccgtga agcggtggaa aatacgctcg gcatcggatc gggacacggg 1129921 ccgacaaacc atttcgcttt taaacgaaac agcttaaata caagccgatg agatcaccag 1129981 ctgatggtga tctcttttgc gtttgctacg gtatgcgctt ttcatctgga caaggttatg 1130041 atatgatagg aattaagatc aggtactaat actatgtctt tattaaatat aggaggcttt 1130101 atacatatga atttttcact tgaaggccgt aacattgttg tgatgggggt agccaacaaa 1130161 cgcagcatcg cctggggcat tgcgcgttct ttacatgaag cgggtgcacg tttgattttc 1130221 acatacgctg gtgaacgcct ggagaaatcc gttcacgagc ttgccggaac attagaccgc 1130281 aacgattcca tcatcctccc ttgcgatgtt acaaacgacg cagaaatcga aacttgcttc 1130341 gcaagcatta aggagcaggt cggtgtaatc cacggtatcg cgcattgtat cgcgtttgcc 1130401 aacaaagaag agcttgtcgg cgagtactta aacacaaatc gtgacggctt ccttttggct 1130461 cataacatca gctcatattc tctgactgct gttgtcaaag cggcacgtcc gatgatgact 1130521 gaaggcggaa gcattgtcac tttgacgtac cttggcggag agcttgtgat gccaaactac 1130581 aacgtcatgg gtgtagcaaa agcttctctt gatgcaagtg tgaaatattt agctgctgac 1130641 ttaggaaaag aaaatatccg cgtcaacagc atttctgccg gcccgatcag aacattatct 1130701 gctaaaggca tcagcgattt caactctatc ttaaaagaca tcgaagagcg tgcaccgctt 1130761 cgccgcacga caacacctga agaagtgggc gatacagctg cgttcttgtt cagcgatatg 1130821 tcccgcggga ttacaggtga aaatcttcac gttgattctg gtttccatat cactgcccgc 1130881 taagcaggct gttaatgatg caagggctgt cttgctttct gtagcagggg atacaaaaat 1130941 cttgagcggt tggctgtttt gccgcgcctg ttagcagggc aagacaaata taaatgctgt 1131001 ttcgcccggg tcatggctac atataaaagg cgtctttcct cctcaagagc ggcctcgtct 1131061 ccttttcttg ccgtttctaa tgagaaatcg tgcggaatcg agccatctac agtgcctaac 1131121 acgtagactg ttttgaattc aaggcctttt gaccggtgaa tggtcatcag ctgaacgcca 1131181 tgttcatccg ttctgttttt ctcagcggcc ctcatatggt ctacgtgggc aagaaagtca 1131241 ggaatcgttt tgaacttctt ggcgacaacc ttgatgtcgc gcaggtcatc agagcctttt 1131301 tccagcttgt tgccctcatt gccccgcttt tttaaatact cggagaagcc catttttcct 1131361 tctgcaaagg tgatggcttc tacgggtttc attgtgcgga ggcttgcaaa aaacggtacg 1131421 attttcttga ttttgtccag ctggaatggc ttcagatcag gcaatttggc cagcgctttg 1131481 atcatggtac agtcctctgt aatcgagagc gccttcagcg tattcaaagc ggactgtttt 1131541 aaaaacaagg cgggaagcaa gtgtttaatc gcctcggtgt catcctcatt ttggctggcg 1131601 tacaagtagg cgagaatctg gcggacgatc cgtctgctgt aaaacgattg gacgccgcgg 1131661 tcagctgtat acggaattga cgattgatga agcctttcat atatagcacg gcctccgctg 1131721 tttgtgcggt aaagaaccgc aaagtcttct ggactggctc cattttgaat tttttctttg 1131781 atatcggaaa cgaccattgt ggcttcttcc tcttcatcat aaggataaaa cagcacaggg 1131841 acctgaatgt catcgcgggc cgcttcaagc gttttggcat atctgttttt gttctttttc 1131901 acaacgatat cagcactaga gacgatcggg tgcgtagacc tgtagttcgc agttaaatag 1131961 atcgtcttcg ctcccggata atccttttga aaatcaagaa tgaaagacgg attgcttccg 1132021 cgaaacgcgt agatggactg gtcatcgtct ccgacacagc acaggttttg ctccgggctg 1132081 gcgagcattt gcatgatttt gtattgaacc ggattaatgt cctgaaactc atcaattaag 1132141 atatacgtaa accgagattg atattgttcc agaaggtcag gccgctcgat aaacaattca 1132201 tagcaggctg aagccatgtc atcaaaatca aattggctgt gttctttttt ctggcgttca 1132261 taatgttcat ataaacgata aacttgtttt tcccactcat cttttagagg gatgcgttca 1132321 tttgggacat aagtgttttt ccaaaaaccg atctgctgca gggcttggtc aactggggat 1132381 tctttctcat cgatgccttc ttcatagagt gcttttttga tatattgttc ccgctgccac 1132441 tccattttca gcagatgctc accgttccat ttagcagaat tagagtgata caagatctta 1132501 taaaacagac tgtggaatgt tcctgtcaca attcttctga cttttgccgg ctgtaatccg 1132561 tactggttcg ccatacgctc tttcatttca gcgacagctt ttgttgtaaa ggtgacaagc 1132621 agcatatttt caggcggtat gcctaagtgt tcgatcatgt gggcggcacg ggctgtcagt 1132681 acccgtgttt ttccgctccc cgcacctgca agcacgagga gcgggccctc tgtttccgtg 1132741 acagctttca gctgatccgt gtttaaaccg acagacggaa aaaggctcgt atcgggttct 1132801 attgtttttg gcacaaatgg tgttcctggt ttaatgcttc taggacggtg ccattctgta 1132861 acagctgggg acgggtcagc ggcgatcgct tttcccttgg gtaaacgaat gacaccagat 1132921 tcctgatcat cttctttttt cccctcttta gagggcttcg gttcgcacgc ctcctcacat 1132981 gccggaaaat cgcctggctg gcgatggata aactctggcg gatcggcgat gttaagccgt 1133041 aacaaaacgg gctttccgca atgagaacaa aataaatgtc cttttattcc ctcttcaaag 1133101 aggaattgat aatgttctct cgaatatgta tgtaaatgta tgattctatc attcagtcgg 1133161 gcgcatttca aaaaggggtc ctcccaatca aaaggtgttc attacagaca atgactatca 1133221 tatcaaaaga aatgtgtttc aaaaagtaag tttaagggaa aagagacagc agaggggtgg 1133281 gtattgtatg atatatgcag gtcaaattca gaaccagcaa tacgctcaat atgctaatag 1133341 aacgattgga cataagcagg attatgccgg aaccgaaaaa atcagctatg tcccgtttca 1133401 gcgggtatac aaagaactgg aaaagcagca ggagaatcaa acggcagctg aaagaaaagt 1133461 aaacgagatg aaacgtaagc gctctcttta taagagattg cgagaaaaag gaatggggac 1133521 atatattaat cgatatgtat aaaaaaccgt tcataccaga gaacggtttt tttatatgca 1133581 gtaaaaatcc ggatctcaaa agatccggat gcgttcagtc cttcatcatt tgtaagtgcg 1133641 gaatgccggc atcgaggaat tctttttcag aaagcacgcg atacccgtgt ttcttgtaaa 1133701 acggcacagc ctgtgtttgc gcgtttaaaa tgaaaccgga agcgcctccg tctgccgcgg 1133761 ctttttcgag cgctttcata atgatgccgc cgacaccggc tgagcggtgg cttttcagta 1133821 cgcaaatccg ctctaacttg ccgtagccgt ccttcatgcg ccatcttccg gcaccgacag 1133881 gcttttcacc gtcatacacg acgatatgct ctgactcatt ttcaagttcg tcaatttctt 1133941 cttcagcagg cacgttttgt tctttgacaa agacttcttc tcttacatag aatgcatctt 1134001 tcagttgttc ttcatttttt gcgataactg ctttcaaaca ttattctcct ctgcctagca 1134061 agaaggtttc atatactgtc cacgatccgt tttccaactg gtagagcaag tggaaacggt 1134121 caacgatttc ttcatgcgac acttcctgca tttttaattg tcccagcaca tctgaatgct 1134181 catcgtcgga aagattttgg ccgaccgtca catgcggaac gaaattatat tcctgttctc 1134241 ctgccaacac accggtgtat agcttttcat tgagtgtttt taactcttcc gtcggttctg 1134301 ctttgatgta aatgacatta ttgacaggcg caaatgagct gtattttgtc attttgagaa 1134361 cgagtgggtg ggactctttt gcgatgtttc ttaaatgtga tacgagctga tccgctttct 1134421 cctccgcgca ttcaaaggat gctctcagcg tcaaatgagg cgggattaga gagtagcttg 1134481 ggtcatagcg ctttctgtaa gagtttgcaa ggtcttggag cttttttgat ggaaataaaa 1134541 cgattccgta tttcatatta tgtccctcct ggaaataaag tatgatagag tgttaaagca 1134601 tttttttcag cgccggggtg atgagcggct gccagtatgt ccatttgtgg tctccgtcaa 1134661 atggctcgaa atcataatcg gaaagctttt tctccagcag ctgtttcagc tcccggttcg 1134721 gttctgtaaa gtccagaatg ttcccgtctg tcgtgtggac gtcagtttct tttgttccga 1134781 tttggtgata aatagagagg tgtttgatat cgtctgactg ttttacggct tctagtacgt 1134841 gtttgtcaac atagggagac tgcatgatga tgttgccaaa catattcgga taatcaagcg 1134901 ctgtcataag tgacacggtt gctccgagcg aatcaccgat cagcgttcgg ccgtaaccga 1134961 tctgataggt tggatactca tcatctgcaa aaggaacgag ctcatgggcg atgaaccgtt 1135021 tataagccga aaattttgaa ccctccggat gataagtgtt tctgcgctct tttacatcct 1135081 tatagggaac accgataata atgctccggt ctatttcgcg tttcgacagc aattcctcaa 1135141 cctgtctgcc gattctcccc agcctgaaat aatcgtggcc gtcctgcgcg ataatgacat 1135201 ggtatttata aagcggggag tagttggacg gcagataaac aagcaaggtc atttcctcgt 1135261 taagctcttt tgaaaagaat ttcttttctt gcactgtgcc gtttttcggt gccataaaaa 1135321 cattcctcca ggacatcact atactttctt gcattttcaa ttattgtacc atgaattatt 1135381 agaaatttct ctctttaaac ggttcggcac acgaagaaaa aagtgttgaa ataaactgtg 1135441 aattgcgcta atataaaaca atcagaaaat tgaaatcgat atttcttatc gtgagaggtg 1135501 gagggactgg cccttagaaa cctcagcaac cggcttgttt tgcatttgca aagcgccaag 1135561 gtgctaaatc cagcaagcgt tttttatgct tggaagataa gaagaagcgt taaacccctt 1135621 cttcttatga agaaggggtt tttattttga aaagggaagg tgtcagctat atgtcacagc 1135681 acgttgaaac gaaattagct caaattggga accgtagcga tgaagtcacg ggaacagtga 1135741 gtgctcctat ctatttatca acagcatacc gccacagagg gatcggagaa tctaccggat 1135801 ttgattatgt ccgcacaaaa aatccgacac gccagcttgt tgaggacgcg atcgctaact 1135861 tagaaaacgg cgcgagaggg cttgccttta gttcgggaat ggctgctatc caaacgatta 1135921 tggcgctgtt taaaagcgga gatgaactga tcgtttcatc ggacctatat ggcggcacgt 1135981 accgtttatt tgaaaatgaa tggaaaaaat acggattgac ttttcattat gatgatttca 1136041 gcgatgagga ctgtttacgc tctaagatta cgccgaatac aaaagcggtg tttgtggaaa 1136101 cgccgacaaa ccccctcatg caggaggcgg acattgaaca tattgcccgg attacaaagg 1136161 agcacggtct tctgctgatc gtagataata cattttatac accggtcttg cagcggccgc 1136221 ttgagctggg agctgacatt gtcattcaca gcgcaaccaa gtatttaggc gggcataacg 1136281 atctgcttgc tggacttgtc gtggtgaagg atgagcggct cggagaggaa atgtttcagc 1136341 atcaaaatgc aatcggcgcc gtcctgccgc catttgattc gtggcttctg atgagaggaa 1136401 tgaagacgct gagcctcaga atgcgccagc atcaggcaaa cgcgcaggag cttgcggcgt 1136461 ttttagaaga gcaggaagaa atttcggatg tgctgtatcc cggaaaaggc ggcatgctgt 1136521 ccttccgtct gcaaaaagaa gaatgggtca atccgttttt aaaagcactg aagaccattt 1136581 gttttgcaga aagcctcggc ggggtggaaa gctttattac ataccctgcg acccagacgc 1136641 acatggatat tcctgaagag atccgcatcg caaacggggt gtgcaatcgg ttgctgcgct 1136701 tttctgtcgg tattgaacat gcggaagatt taaaagagga tctaaaacag gcattatgtc 1136761 aggtcaaaga gggagctgtt tcatttgagt aaacacaatt ggacgctgga aacccagctc 1136821 gtgcacaatc catttaaaac agacggcgga accggggcag tcagtgtacc gattcagcac 1136881 gcctcgactt ttcaccaatc ttcatttgaa gagttcgggg catatgatta cagccgctct 1136941 ggcacgccga caagaacagc tctcgaagaa acaattgccg cactggaagg cggaacaaga 1137001 ggatttgctt tcagttcagg catggctgcc atctcaacag catttttact gctgtcacag 1137061 ggtgatcacg ttcttgtgac agaagatgta tacggcggaa ccttccgtat ggtgacagag 1137121 gtgctgaccc ggtttggcat tgagcatacg tttgtcgaca tgacggatcg taatgaagtg 1137181 gcgcggagca tcaagccgaa cacaaaggtc atttatatgg agacgccatc aaatccgaca 1137241 cttgggatta cggatattaa agcagttgtt cagcttgcaa aagaaaacgg ctgcctgacc 1137301 tttctggaca atacattcat gacgccggca ctgcagcgtc cgcttgatct cggcgtggat 1137361 attgtacttc acagcgcgac aaaattctta agcggacaca gcgatgtgct ctcaggtttg 1137421 gctgctgtca aagatgaaga gcttgggaag cagctgtata agctacaaaa cgcgttcggc 1137481 gccgtccttg gcgtgcaaga ttgctggctt gtcctgcgcg gattaaaaac attgcaggtc 1137541 cgtttagaga aagcgagtca aacagctcag cggcttgcgg aatttttcca gaagcacccg 1137601 gcggtcaagc gcgtgtatta tccgggactg gctgatcatc ccggcgctga aacccataaa 1137661 agccagtcaa cgggagcggg cgccgtgcta tcttttgagc ttgaaagcaa agaggccgtt 1137721 aagaagttag tcgagaatgt gtcactccca gtcttcgctg tcagccttgg cgccgtggaa 1137781 tcgattttgt cctatccggc aacgatgtct catgcggcaa tgcctaagga agagcgtgaa 1137841 aaacgcggta tcactgatgg cctgctccgt ctgagtgtcg gcgtcgaaca tgcagacgat 1137901 ttagaacacg atttcgaaca agcgctgaaa gaaattgctc cagtttcggt tcgttaaaaa 1137961 agaagccggg gatagtccgg cttcttttat tattgttcgt catcaggatt cagaatcgcg 1138021 aggacttgat gatcctccca aacgccatta atttttacat tttttcgggc gatgccttct 1138081 ttatgaaatc ccgctttttc taaaacacgc atggacccga gattacgggg catcacaccg 1138141 gcttcaatcc gatgcagttt caattcgtgg aacgcataat caacaaccaa tctgactgcc 1138201 tctgtcataa tgccctttcc attatgggct ttgtctaaaa aatacccgat gaacgcagtt 1138261 tgcagcgcgc cacggatgat ttgaaagagc gaaaccgtcc cgattaatct atcgtctgac 1138321 gctgtaaaga tgccaaaatg atattcttca tctttctcaa gtctttcctg atactcggtt 1138381 attcgttttc tttgcccctc aaccgtatag taatcgtctg cgcgtatcat agaaaactgt 1138441 tcgaaaaaat ctcgattttc gctttgcagc cccagatttt cttcggcatc cgttacttct 1138501 aaaggtctaa cataaatggt ttttcctttt aacatatagt gatctctccg ttctcatgtc 1138561 agcattcctc ttacattatt ctcagggaaa tgcaaatatc ctttttataa gaaggaagaa 1138621 aaccaatttc ccataaaagt gccaacatag ttgccgatta agtagccgag cgtaccgaca 1138681 agcatgatcg gggcgacaag ctcccgccat cccttggcaa ttgccatcgc agccgcagtc 1138741 gtcggtcccc cgacagtagc gttgacggcg agcagaattt cttcaagccg cacacggaac 1138801 aattttccgg cagctaagga aaccgctaaa ttgctaatcg caatgataaa cacgaataat 1138861 agaataagag gcgcattcgt gacgattaag cggagatctg caggaatgcc gatcaccaca 1138921 aaaaacaaat aaatcaaaaa ggttccaagc tcctgagatc cattgagcct ttcaaaaaaa 1138981 cgcgggaaaa gaaaaatgat aagaacagtt aaagacgtaa gaaccaggta ctgatcgcca 1139041 agcgtaccgg tcagcagggg atgagaaaaa atgcttttaa aataaccgga aaccttcata 1139101 ctaaccgcaa caagcgcgaa agcggcaccg gcattaaaag cgatatcctt taaggaaata 1139161 tccttccgtt tccaatagct ttcagcactg tttccgctgt ttccatcggc ttttaccttc 1139221 tcttcaaacg gcatggcata atgccgctga aaccatttga gtgcaggaat gctgattaaa 1139281 ataaaaaaca aaagcgccat cataaaatta tcagccacaa cggtagccga cacatattca 1139341 ccaggcgtct caaattttgc cgccatcgcc gcaaagttga ccccgccgcc gatataagag 1139401 gcgctgatca tcccaccgat tttatctaag taaggaatat gctgtttgag tagaaaaaaa 1139461 gccaggatac tgccaagcac tgttccaacg gagctaatca gaaaaataaa cagcaaacgc 1139521 ctgctttcct taaaaatttg cctaacattg atctgaaaca ataaaagtgg tatcgccagc 1139581 ggtaccacat aagaccacac agtgtcatac acgggcgact caacaggaag cactcctaca 1139641 tttgtaaaca ccatagcacc tgcaagggcg ataatagcgc ccgacacagc agacgcccac 1139701 ttaaagcgct gctccagccc gatgctcact gccgcccaca ccgcaataaa cccccataat 1139761 acccatacat catcagaaga aatcaaagaa tgcaaaaccc catcacctct attgttagaa 1139821 aattaagaca tattataata gccggggaac ggaacagcaa gtccaaaaaa agtttttcta 1139881 aaaaagcagt tgacgaatag aaggtaaggt tatataatag aacttgtcag aaagataaca 1139941 acatacccag caacacatac atatcatgat tccgtagctc agctgggaga gcgctacctt 1140001 gacagggtag aggtcgctgg ttcgagccca gtcggaatca tagcttaaac ccttgcgcag 1140061 caagggtttt ttactttgcg ttaataaagc cggttcgtca aattcgtgag ttgttggcga 1140121 actgttggcg aaattcattg accgcagtcc aaaaactacc tccaaactta cttgattagt 1140181 tcaatagtaa caaacggaag atcggatttc tgttaaatct tcattgagaa tagccagtcc 1140241 aagaccgtca cttcagccat gcatctttta aatgaaattt tgtactgaaa acatcaattg 1140301 tatttttaaa ttctgctcta gaatcagccc ctttataata atcttgataa attgcttggg 1140361 gtgatactga ttcgtgattt gtgctatggt ttgcaaggct tgtagcaaaa gcaggagcaa 1140421 cagtaacgag taaagcaagg gataatgcaa aaccagttaa agctttttca atttcatttt 1140481 aagcacttct ttttttaaaa tacaacttta ttattaaatg gaatacaaaa acatccaagg 1140541 tgtttttttg ttagtaagtt gagttagggg gattggatgg cacttagaat attgtttctg 1140601 ctgatgggat gttgattctg gatatatttc caacacgatt acaggccgga catgaaagcg 1140661 aaccttgctt tgatcggggc aatcatttca tttacggctg cggtttactt taaagatatt 1140721 gatgtattga gagaagaggg aaaacaaatg aacggaattt ctgagcgttg gaacacgttt 1140781 aaattacaaa aatcccctga accactctag atcaggggat tgctttccca acagcttatt 1140841 aagtagcgga aggcatgatc aacgatttag tatcaattta ttaattgcga atactagaaa 1140901 cataccgttt tccgccttcc ttagaagtaa catattctcg aggaacatta agtctattgg 1140961 tagaatgata acttacataa agtttcatat ttgctcggct cgttacgata gccgtatgat 1141021 ccatccaacc atcagcatag cgaagaccta ttttattatg gtaatcatag tgatatacat 1141081 ctccaagctt tacatttgaa tatgtatcag aaacagtctt catttttatt ccgccagctt 1141141 ttaaaatgta tgatctaaag gctcctgcat taacccaagc atctgtatag ggtttccatt 1141201 ctttaaagta cggcattctt ccagctctta atgcttggga aacaaagtta gtacaatctt 1141261 tgtctttata atatttatag tttttatttg gttttaaggc atatttttct gcatatttca 1141321 ttgcagcgta accactatat cctttaacag atgttgcagt cacagttagt tgattagagt 1141381 tagcagcatt gaagttcata cttactggtt tatcttcact tttcacttct tctttatcat 1141441 catttttcac ttcttgctta tattttttta aaaattcatc taatttaaca tccgaagaat 1141501 attcttcatc attttcatat tgtagagttg aagaagaatt atttaattgt gttacattta 1141561 gttgcttaga agaattactc aatggtatta catttagttg attagaagaa tttttaactt 1141621 gagagaaact tagattagaa gtatttgttg attgagaact ttgtttatta gaagttgttt 1141681 tgggaatttc aagtttaata ttatcgccca gagatgttgt tactttttca acaccaaaaa 1141741 caaagtttcg agtaatataa gcttcaacaa ttagcttatt gtttttttca gaagtcttaa 1141801 catcgtctat atcgtatgta aactcgtgga atttttgttt gtccacttta cttaacgcag 1141861 aatacagtaa gactccttcg tcggaatcag tcaatttaga ctctttagga tgcgctaaag 1141921 gagtgttgtg ttcaaaatca tatttttgtt gttctaacat atccttaact ttttcgtaac 1141981 caatctcgtt ggtaattgaa acattttctt tagtctcttt attagtagtg gctgcaaaaa 1142041 cttcatttgt tgacactaat ggtgacaatg atagacataa aactagtgaa gcaagtaatt 1142101 cttttttcat acgaaacctc caataaaatc taaatataag taatatttat catttacacc 1142161 aattgaaata tggcataaaa tacatgtaat aatataacat aaaaataaat acataaaaag 1142221 gtatcggagg aaaaaatgaa aaagaaaact aaaattatac tttctctctt ggcagcactt 1142281 attgttatat tgatagtact tccagttcta tctcctgttg tctttacagc ttcttcggaa 1142341 aaaggagcaa tcagacacga aatttataaa agaggatatc cctaccaaag ctactttgca 1142401 gttctccaga aaagagaagg agacaatgaa tctgggaatc tttattatgt aaattggcta 1142461 gattggaaag atgaaacagg gcaaactcct cacttatgct attcgaaaaa atcatcagat 1142521 ggtgaatacg aagtaagttg tggcacaggg ccgtaaaaat aaattttaaa attgaataag 1142581 tccaagacgg aaagcctgcg gacactgatc gttttacaga gaaatttgtg cttcgatcgg 1142641 tgtccgtttt ttttcgcaac taaccagatg tctatcgcga ttactagcta tgaaaggagt 1142701 aattagacat gaaacagtcc aaaaagaaac catcacagaa gcaacatgag cgcttagatc 1142761 gtttctggca acaaatgatg aacactaaca tgcaaacact cagacgtggc aaaggcggcg 1142821 cttataaacg cagaaagtaa aaagggagtt tgaggatgat gaaaaacgga ttcgcttata 1142881 aaaacggaaa gcttgtgaat atcttttgcg gcaaagaaga gctctataac gagttgaaag 1142941 ccttcttggt caaaaccttc agtatcaacg tgaaagaggt atcgaggccc tcaatatatc 1143001 gcagaacaaa aagcaaacaa ctggaatgac acttactcta tttaactatc aggagggaaa 1143061 gcactatgac agatcaaatg attgcatggg agattgagga atggattcgt gattataaat 1143121 tcatgctgcg ggagatcaaa aggctcaacc gtgtattaaa caaagtggat tttattagca 1143181 caaagctcac tgcaacatac ggggaggaag cgggcatgcc aaggggatca gcaggcgtca 1143241 gtcaggcaga attgcggcag atggaccgaa gagaaaggcg gcttcacaaa tatgaatcta 1143301 ttgtgcatta cctggacaat gcaatggaac acattgaaga agaaaagcac cgaatcgttt 1143361 acgattgcat gatggaaggc atgagctaca ctgctattgc aaaccacctt gattgctccc 1143421 gggataccat cagaaagatc aaaacagcca taatcggcaa catcgtcaat aaagtcaaag 1143481 aagccaactt tctgcaatat ttgaattcgt ttaaatcggc ggtgtaaaat ggggggcagg 1143541 atcggcgcgg cggattattc ctgcgtcacc accaatttca tacaatgagt aaaacctccc 1143601 agtggtaagc gaggatcaac tcaactggga ggtcttacat agtgaatcgg tgataaaaca 1143661 gcagcagtat tgcgtacatg ttaatatccc cgacaaaata tgtttttttc aacagattcg 1143721 ttcgacaaat tttgcaaatt gttaatcgat aacttttcat tcccgatatt aaaaatggga 1143781 gtgaattgta aaatgaaaaa acagaaaaat aataaaaaga agaatattga aaagcgaaat 1143841 attgaaaagc gaaatattga agagaagaat aatgaggact tagaagaact ggaaaatgcg 1143901 atttatactt atcacaaaaa ggagctactt gctttctttc ttgaaaaaac tcgaattggt 1143961 catgataagg aagaatacaa aaggttccaa tctcttcttt ataagttgga tattgaatgt 1144021 ttagaatttg ctatatcgag attttctcat atagatatta tccatgatca ttcaaaatat 1144081 gttccagcct ttatcccttt atttgcagca tatctcacca tgttctttaa tttttatgaa 1144141 aaacattggg gagctttatc ttttgctgct ggtacaattg ctgctattgt ttggataatt 1144201 gcagtagaaa gaaaacatag aaatcaagca atttctatta tgaaaatatt tgaacaagtc 1144261 aaagagagaa aagtgaaaga cagatctaaa gactgaaagg agaaaatatg aataaggata 1144321 aattaaggta tgcaatctta aaagaaattt ttgaaggtaa tacccctttg tcagaaaacg 1144381 atattggagt tactgaagat caatttgatg atgctgtgaa ctttttaaaa cgcgaagggt 1144441 atatcattgg ggtccattat tcagatgata gacctcattt atacaaatta ggacctgaac 1144501 tgacagagaa aggtgaaaac tacttgaaag agaatggaac atggtctaag gcctataaga 1144561 ccattaaaga gattaaagat tggattaaat aataagagca tcctgcgggg tgcttttttt 1144621 gttccctgta aactgcttcc ggtaagtctc aggatagaca attggcggtt aacggcttga 1144681 gcacggtggt ggtttagagg gaatatcttt tccaaaacaa cacgaatcag aagggggcgg 1144741 cggtgaatgt agatggccga aaagcacatt caggcgtata aggattacgt caaaggcatg 1144801 aaatacaagg accttgccga gaaatacggg gtgtcagtga acaccattaa atcgtggaag 1144861 cagcggcatg gttgggaaag gaaaaagggt gcacccattg aaaaaagtgt gcacacaaaa 1144921 aaaggcgggc aaccgggcaa caaaaatgca ttagggaaca atggcggcgc accacagaag 1144981 aatcaaaatg ctgtgactca cggctttttc tctaaattct tgccagaaga gacgcttgaa 1145041 atcatggaag agattcagga gcgttcgcca gctgatatga tatgggatca gatacagatt 1145101 caatatgcgg ccattcttcg ggcgcaaaag atcatgttcg tttctgataa ggaagaaatg 1145161 atcaaagagc tgaaaaagaa aaggtccctc atatctgagg tcagcgaaat tgaagatggg 1145221 cttgtcatta gttttagtac gtggtttcgc tacagacttt acagtgaaac aaacacctaa 1145281 cacatttcac attgcttcag attgccttca aacttgataa tataacttct aaaccttcct 1145341 ataaaatgaa ggttttttat ttgatttcaa tttttaaatc ctttacatac agcgattgat 1145401 taactcgagc aatcaatgtc gcagttatat ttatttttca agaaaatgtt ataatgaaaa 1145461 gccataaaat gatgggaggg ggaatttcga tgcattacat aacggcatgt ttaaaaatca 1145521 tcagtgataa agaccttaat gagataatga aggaattcaa aaaacttgag gaagaaacga 1145581 acaaagaaga gggttgtatt acattccatg cttatccgct tgagccatca gaacgtaaaa 1145641 taatgctttg ggagatttgg gaaaacgaag aagctgtgaa aatccatttc acaaaaaaac 1145701 acacaataga cgttcaaaaa caagaattaa cggaagtaga atggttaatg aaaagcaatg 1145761 tgaatgattg aaaggctctt taaaaagaga cattcaatga cttagtatca gccacttgtg 1145821 actaagtagt aaattgttgt ccaactctta ttttttctat ttaatatttt ttgagacgaa 1145881 aatgtttttt taagctgatt ttaaaatgta ttcaaagtca gctctgtttg atttaatgga 1145941 ttatattatt tggatagctt gttaccatca taatggagat actccttata aattggaggt 1146001 taaaataatg agtcattctc aagaaaaaat tgcactaatt acaggagcaa gcagtcaagg 1146061 ggatattggt acggctattt gtcgtaagtt agcctcacag ggtatacata tcttctttac 1146121 tcactggaat tctgatacgg cctggataga agaatttcaa caagaaattt tacgtatggg 1146181 tgtccgctgt gaggcaatga aaattgattt atcagatgca catgctgcat tcacaataca 1146241 tgaaaaaatt tcagataaat taggatatcc ttccatcctt attaataatg cagctcattc 1146301 cgcaagtgat aattatgtat cgttagatgc taaatcactt gatgagcatt atgcggttaa 1146361 tatgagatcg aattttcttc tttgtgttga attcgcccgt cggtttaaaa aatctaattt 1146421 aatatcagga agaatcatca atatgacatc agggcaggat ttaggtcctt tgcctgggga 1146481 gttagcgtat gcagcaacta aaggagctat ttctgcattt actaggtcgt tatcacaaga 1146541 acttgcacca ttgggcatca ctgttaacgc cgtaaaccca ggtccaacag attctacatg 1146601 gatgacagat gaaataagaa attttctttc acctaaattt ccaatggggc gtattggcac 1146661 accagatgat gcagcacgaa tgattgcctt tcttgcaagt gatgaggctg aatggataac 1146721 tggacaaatt attcattcag aaggtggatt tattcggggc taagctaatg aaacacggta 1146781 tacaccaatg tatgatgtat tcccaaaact aaatctaaac ttgaagcgaa aataaggtcc 1146841 cttctctttt tagaggggga ccttatttta ttcatgcatg ttttgcatcc agaaaatctg 1146901 gcggataaag attaataaac cgttacatat acttttccga atactgcagt acctttaaac 1146961 aaagtaatcg tggctttccc ttttgattta gccgtcacta aaccattttg atcgacttca 1147021 gcaacttttt ggttatcagt ccaataacga gtagctgaat tatttttaac agaataggtt 1147081 tctccaactt ttagaggtaa attatagtct tgaatcttga taacatgtgt aggtgaaata 1147141 gaaatgttct ttacttcagt aggtgtggag tttatttcat gagctgaagc taccccgctg 1147201 accgacagag ctaacgcaga aatcgataaa gcagaaacaa ccgttttttt gaaattcatt 1147261 ttgaaacact cctttaaagt tttttgtctt gcactataac aattcaataa aagtaattat 1147321 tttccttgta aataaatgtt aataatatgt gaacgatcaa ttgatttgag ctaagaatat 1147381 tgtgtgccct gcacagagtt tgtatttatg atggaaaatt gctgagagag aatggccatc 1147441 cttaaaatgt taatagcaca catttgatgg gtattagttt gttgagcgtg tggaaatttt 1147501 gttacctgca ctttatcccc gaagatacca aatcactttt cttcatcatg ttcttacttt 1147561 cgtactcata cattagaaaa tcttcgttct aaataggtga agaattggag tatttttatg 1147621 aatttctgct gaatatacat tacatagcaa actcaaagag tataaaaatc gcttttttcc 1147681 ggaagcttcg gtaaaaaacg aaacttttgt ctctatgatt ttgttttata atgtaaacgg 1147741 tttcttatat agtatactta tactatcaat ttgctcaagt agatactgac aggaaggata 1147801 gaaaaacaga tggaatacat aaatacaaga caaaaagaga ttttgtatct gttgttatct 1147861 gaacctgatg actatttagt tgtgcaagat ttcgcagata gggtacagtg ttctgaaaaa 1147921 acaatccgga atgatttgaa agtgatcgag gattatctca atgagcattc tcatgcacag 1147981 cttattcgaa aaccagggtt gggcgtttat ttacatatag aagaacagga aaggacctgg 1148041 ctaagccaac aattacatac tgaacatttt tcttctaggc agcggagcga taaggaaaga 1148101 atgctgcaca ttgcttatga cttattaatg aatccgaagc ctgtttccgc aaaagacatt 1148161 gccgctcggc attttgtcaa tcgatcttcc attaaaaagg atttatacgc agtagaagag 1148221 tggctgaagc gttttgatct cacactggtt tctaggcagc ggcttggatt aaaggttgaa 1148281 gggaacgaaa gaaataaaag aaaggcattg gcaagaatat ctgatttgat tcacaataca 1148341 gcgtttacca gccaatttat taaaagtaag tttttacatt atgaagtaga ctttgtgacg 1148401 aaagaaatca aatcactaca aaaaaagcat tccctctatt tcacagacga aacgtttgaa 1148461 agtttgttgc tgcatacatt gttaatggtc cgccgcatca aaatgaagca gccgatttca 1148521 ttgtccccaa aagaaatggc ggcagtaaaa aagaagaaag aatatcaatg gacatttgct 1148581 tgtttacagc ggcttgaacc ggtttttgca attcgcttcc ctgaagaaga agccgtgtac 1148641 ttaacattac atatattggg cggtaaggtt cgttatccat tgcagacaga agagaacctt 1148701 gaaaatgctg tgcttcctaa ggttgtaggg catttaatca atcgtgtttc agagctgaaa 1148761 atgatggatt ttcacaagga tcaggatttg atcaatggtt tgaacattca tctcaatact 1148821 gtgctacaac ggctgagcta cgatctttct gtagcaaatc ctatgctcaa tgacatcaaa 1148881 aagatgtacc cttatttgtt ccacctcatc attgatgttt tggaagacat caatcaaact 1148941 tttgatcttc atattcctga ggaagaggca gcatatttga cattgcattt tcaggcagcg 1149001 atcgaacgga tgcagggcag cagcgagaca cataaaaagg cggttatcgt ctgccacatg 1149061 gggattggga tgtcacaatt gctgcggaca aaaattgaac ggaaatatca ccaaatcgct 1149121 gtaatggctt gtattgcaaa ggccgattta aaggattata tcaaaaagca tgaggatatt 1149181 gatcttgtca tatccaccat tgcgctggag aatataacgg ttccccatat tgttgtgtct 1149241 ccgcttttag agcctggcga agagaagaaa ttaagtgcgt ttatacgtca gctgggcgaa 1149301 tcacaccgcc aaaaacaaaa aacgtttcag atgctgaaca atacgactcc ttttttggtt 1149361 tttttgcagc aggaggcgga gcatcgctac aagttaatcg aacagctggc gacagctttg 1149421 tttgagaaag gctatgttga taaggactat gcggttcatg cggtgatgag ggaaaaaatg 1149481 tcggctacaa atattgggtc aggcattgcc attcctcatg caaacgctaa atttattaaa 1149541 caatcagcaa tcgcgattgc cacattaaag gagccgcttg aatggggaaa tgaaaaagtt 1149601 tcgctcgttt ttatgctggc tgtcaaacac gaggatcaaa ctatgacaaa gcagctgttt 1149661 agcgagcttt catatcttag cgagcagccg gccttcgtcc agaagctgac gaaagaaacc 1149721 aatgtcatga catttttatc tcatttggat tattaaaagc agggattatt ccttgctttt 1149781 tttgttcatg gcagggcttg agaaataaat ttgcgagtga agacgcctat tctccagcaa 1149841 tgatctaaat aaaataagag tttaatagtt ggagaagaaa tgttacactc ttttctgtat 1149901 atggtaaaga atgaaaaaac acgattcggt tggtagtccg gatgcatgat tgagaatgtc 1149961 agtaaccttc ccctcctcgg gatgtccatc attctttaat atcttttatg aggagggaat 1150021 cgttatgaaa ttaacgattt actacgatgg tcagttttgg gtaggcgttg ttgaagttgt 1150081 ggacaatgga aagctaagag cctttcgtca tctttttggc aaagagccga gggattctga 1150141 agtattagag tttgttcata accaactttt gaatatgatg gcccaagctg agcaggaagg 1150201 agtgcgttta caaggcaggc gtcaaaaaaa gatcaatcca aaaagattgc agcgccaggt 1150261 ttcaaaagag ttgaaaaacg ccggagtaac ttctaaagct caagaggcga taaagctaga 1150321 gcttgaagca agaaagcaaa agaaaaaaca aataatgaaa gaacaacgag aacatgtaaa 1150381 agagcaaagg tatatgctca aaaagcaaaa agcgaaaaag aagcacagag gtaaataatc 1150441 caaacaaaag caggcgcagt gcctgctttt gtaattaagg actctacttt gtaacatata 1150501 tccaatgttt atactccgct gatttatgat tcaatataaa ccctaacttc tccaaggttt 1150561 tttgtgagcc tagattatca tgttcgcatc ttgcggtgat ccgggatact gtttctcggc 1150621 ttaatgccca gtttattagt ttttgggcgg cttccacaca ataacctttg cggcgatgac 1150681 ttttatttgt tgcaaaaccg atttcaatca tgccattttc gtctgggtca cctaaaaatc 1150741 cagttccccc aacaatttca taattgtcct tctttacaat aatccatgaa tcaaatcctt 1150801 ttgttccatt gtttttgact aaaatctcgc ggaaataagg tatcgcttca aaaaaatcag 1150861 aatttggcca ttcaccattt gtttcatagc ctaattcttt gatagcctga tgatcttgtt 1150921 tagacgcggc gtcaagaagg ggaatatcaa tcgtttgtaa tcgtaatcga ttcgtttcaa 1150981 ggagaaccat atatttaatc ctcttttctt tttactggga ataatgataa catataacaa 1151041 ttttctctgg taccttggca gtagagaaag atgaaaaaat tgagggggat tgaaagagtg 1151101 acaggtgaga gtttgcccag accaaaaacg ggtaggaaaa tgctgatgtt aatgtgtccc 1151161 tacccgtttt tctgttcctg aatgcagggt ttctgataac atgttgtgct accttttcgc 1151221 aatcaaataa agcgatatgg ctctttgggt ttgcacagga ttatgaatga taatgaccca 1151281 ttggtttctt cgtcttggaa agcttgctac cgcatacaat ggagcagtat cgcgcggagt 1151341 gaacccacca tttatcacgt tgatatctct tccttcaaga tgacaaacta agtattcacc 1151401 tggattgatg acctgttggt tcgtccatgc gtaagaataa aagccgtctc caagatcttc 1151461 ggtggaagat ggggggacaa agccatctac agtcaatgtg atttctcttc ttcgctgtct 1151521 ttctgaaaag tctggacttc tttgagggtt atgagtatgt gaaaagtaag gaattaacgc 1151581 agggccataa aagtaatgat acaaagcaac cactccttta ttttccattc atacaaattg 1151641 tatgtgggag ttatttgttc attcctgttt tgttccatgt agactaataa tgggctatag 1151701 gcgtccaagg aaatcaattt gtccttccgt tgattcaatg ctagtaacct tgaaaatgca 1151761 ggttaggatg atagaattta catattactg caagaagtta gacatacatc attttgatag 1151821 tgggtgaaaa caatggcgaa aaaaatggca aaaacaaatg cggttcgtct gatagaacag 1151881 cagaacatct cttatgaggt attagggtat aaaacagacg gccagccggt agatggcatc 1151941 tctgttgcgg aaaaaatcgg ttattctttg aaatatgtat ataaaacgtt ggttgcagca 1152001 gcaggaacaa atcattatta tgtctttgtt gtacccgttg cagaagagtt agatgtaaaa 1152061 aaggcagcaa aggtgacagg ggaaaagaaa atagaaatga ttgcaatgaa ggagctgtta 1152121 gcggtaactg gctatcttcg cggcggctgc tcgccaattg gcatgaaaaa attgttcccg 1152181 acctatattg atgcatctgc agaaacgctt gattttatta ttgtcagtgc agggaaaatc 1152241 ggtatgcagc taaagttggc gccacaagat ttagccagat catgtgatgc cgcatttgca 1152301 gaaattgtat agatgcagat ataggggaac gaaaaagctt agtcatatcg attaagcttt 1152361 ttccgcatcc ctttcaaata tgatttcaaa ataagcagct gccccatacc catctatact 1152421 gggagcgaaa atctgaacga atctccagcc tcttttcgca taatcatgga tgatttgctg 1152481 gtagtcttct ttaggccttc ttctcatcgt actcagctca actcttacga attcatattc 1152541 tttcatcgtt tgatccctcc tattaaggta tacgtaaaat ggagcgagaa gttccgaaaa 1152601 cctaggttaa ggtcggaaag tatatttcac tcactaaaca aatccattta tgcctgatgc 1152661 ctgcatgcat ctgggaagag ttaaggggct ataaaaacga attttaccgg gtcagcagtc 1152721 caaatgaatc tcttgcttat tgcatttgac tgagtatata agtaaaaaaa gagcggccag 1152781 aacatataag aaggagatga tcattaacgc actcataaca gggtagtgtt tagcggagta 1152841 gatgaaaaaa tcaagctgtg aaatttgttt ggggctgctg acggcatcaa ttccattaag 1152901 cagttttgag agtttagcag tatagttcca atcaaatcga tctgaaacaa gctcgcttcc 1152961 ttgataccaa ttaacagcag ctaaaaacag aaataccata atagaaaatc caagctgaac 1153021 aactaaaaat attcccttca cttttgtatg acctccaaat ctatgaatat gggaaaatca 1153081 aacaatatat taccaccgta tgggttattc ttgcaatttc acttccatac aactcaaacg 1153141 caagtctatt tttttgtttg tttttggctt ataatacctg atgatggaaa aagagtgcgg 1153201 gtttatagat tagagaaaca aatgtatttc ttagcatttt ttatttgtgg agagagtata 1153261 gaagcattcg attagatctg ctttttcaca gaaacggttt tcatctgttt gcctgagctt 1153321 tacaattggc tggcaaaaaa acaatgattt ctttcaatca aaacatgcaa cgatgcgaca 1153381 cattttatat cttgatgact tatttcattg cctttaagtc atcctatcga gaaagcgatg 1153441 gtattttatg aacaaagaaa ccctaaaaaa catactcatg attttttcaa tatgcgcaac 1153501 actccgagaa accgatggta tgcgcatagc tgatagctgg attttgagtg agattatacg 1153561 atttttgatt tgcatggttg tgttttttgc catgacattt ctattagatg ctgtttttcc 1153621 aaacaaaaaa gagtcacatt aatgtgtggc tctttttgca tcatctgatc agaaacatca 1153681 taaatgaatc gatcatcatg atgaagaaca gcaagcaaaa ataaataagc gagtagacaa 1153741 acatatcctt tgcccacttc acgtcatcgt ctgttttgaa tcctttgatg ctttttttga 1153801 tccatatgcc tccgagaacc aaggcggcta agaaataaaa tgggcttata tggccggtgc 1153861 cgagagagaa aggaaataat agcgtgaccg gcaccaggac ggcaatatat tgcatcattt 1153921 ttatttttgt tacatgattg cctttgacta ctggcaagag cggaacgcca gcagcgcgat 1153981 attcctcttt gcgtcttatc ccaatcgccc aaaaatgcgg cggctgccac agaaacataa 1154041 tcgtgtacaa cagcactgct gtcatactga agtcaccggt tacggcacaa taccccatca 1154101 atggcggcgc agctcctggg aagctcccga caaatgtgct ccacacagac gttcgtttca 1154161 cccataccgt atagatgatc gcataaaaaa taaaggcggc cagtccgaga aaggccgtta 1154221 atggattgag ggaataaagc atggcaagac ctgcgattcc taaaacagag ccatatgtta 1154281 agatcatggc tggcggcatt ttccctgtga ccgaggccct gctgcgagtt cgtgccattt 1154341 ttgcgtccat atgccgatca aaatagttgt tatagacagt gccggaagcc atcacaaacg 1154401 cggttcccaa cattgctgtt accattgtca tcaaaaaagc caagccggtt aacgtttttt 1154461 ctgcgcttgc aaacgcgatc caaaacccgc cgaaggctgc tatcgagttt gatatgataa 1154521 tgcccggctt tgcaagtttg ataaaatcgt aaatggttac ccggttcgaa gcttttatgt 1154581 attttgtttc agatatggct gcagaatctc ttgtattctc caaaaataga cgcctccccc 1154641 aaaactgcat gcttttgtta tcgtaacaag agggggacag aatcacaatt atttcccata 1154701 tttgtcatga tattgtcatt tttaaaacaa aaaaatgggg agctggactg cccccatttt 1154761 gatatgtggc gactagtaac cgtaacctcc cccatatcct ccgccataac ctccgccgta 1154821 accgtaccaa gggtagtaag gcggtcgcgg gcgcgggtag taataaggcg ggcgcggata 1154881 aaacgggtag aacggataat acggtcttgg ataataataa ggcggataaa atggcggtct 1154941 cggacgcgga taataataag gctgtctttc atcataaggg gtaatttgtt caaatgactg 1155001 ttcattcaaa gggtaatcca agaggaaaac ctccctagct ttttttattc cttttaccat 1155061 attcctgatg cttaagttgg gtgtatgtac attcatgaaa ttcggttttt tttatgatga 1155121 aattccttaa aaaggattga catgaacttc taaatctcat agtattacaa atgtgaaata 1155181 aatgttacta caatgttaca aaaacatttc taaatagata cagttccaac tgatgaagag 1155241 taaatcgaaa tggctacgaa agaaggagtt tttgttgttg gcaaaaagaa tcaaatggtt 1155301 tcatgtatta atagcagttg tatgtgtggt gggccttatc ggctttttcc ataatcattc 1155361 attgaaaaaa gaaacggtca tgaataaagt aagaactgat tctcaatatg ggaatgttga 1155421 gatcgcaacg cttgtgaatg acgggaaaac ttttaattac gcggtaaact atcctgtttt 1155481 caaaaatgaa aaaatggatt cggcattaaa aagattcgca gaaaaagagg ttcgtcaatt 1155541 tcaaaaggaa acaaaggacg ttgaccaaga gcatacgaca aaacgcaacg aattaaatgt 1155601 tgattataaa attgtccatt atgccaaaca gacagtggcg attgtattta atgaatataa 1155661 atacatcggc ggggcacacg ggcaaaccgt gaaaaaaacg tttaactatg attttagtaa 1155721 acaagcgttt ctttccattg atgatatttt caaagaggac gctgactact tacataagct 1155781 ttcgttaatc gcttatcacg agctgaaaaa gaataaggac attgccgcgg acgatgcact 1155841 gttaaaggaa gggacggctc cgaaaaaaga aaatttcagc cgctttgcca tcaaggagga 1155901 ttatatcgaa ctttactttg acacatatca ggttgcagca ggctatcttg gagagcaatc 1155961 gattgccatt aagaaaagtc ttttgaaaga cattctgaaa gaacaatata ttgataaagc 1156021 aaaaaataaa aataaaatca aagaacaaaa gccgaagcat gaagtgattt ctttacccaa 1156081 agaggaaaca gttgatccaa atcaaaaagt cattgcgctt actttcgacg acggcccgaa 1156141 tcctgcgaca acaaatcaga ttctagactc cttgaagaaa tataagggtc atgccacgtt 1156201 ttttgttttg gggagcagag ttcaatatta tccggaaacg ctaataagaa tgctgaaaga 1156261 aggaaatgag gttgggaacc attcatggag ccatccgctt ctcacaaggc tttcagtgaa 1156321 agaagcgtta aagcagatca atgatacgca agacatcatt gaaaaaataa gcggatatcg 1156381 tccgacgctt gtaagacccc catacggcgg cattaatgat gaactgcgga gtcaaatgaa 1156441 aatggatgtt gcgttatggg atgttgaccc ggaagattgg aaagaccgta acaaaaaaac 1156501 aattgttgac cgtgtcatga atcaggcggg agatggaaga accattttga ttcacgatat 1156561 ttaccgcacc tctgctgatg cggccgatga aattataaaa aagctcaccg atcaaggcta 1156621 tcaattggtg acagtttctc agcttgaaga ggttaaaaaa caaagagaag cgaaataaat 1156681 tagaaaaggc tgtccgtacg gacagccttt tttctattta ataagagcct gtggtggccc 1156741 aaacatttaa gtttggtcct gaatacttgc cgaaagcgta agaagtcctt ggatctaaat 1156801 catataccat cggtgtatag caagactttt ggccggccac cgcttttcca ttgccgcctg 1156861 cagaatcaca attatatctt tttccgtctg tgttccgggt aatctccgca tttgcttcat 1156921 agccagacgt caatgtatta ttcatcgtga tttttgccca agccgtttta catgtactgc 1156981 tgaatttaag ctcgactact ccgatgactt gattgctggc attcactaag tttgaggatt 1157041 tttttgtaga gccgctggac gcacaatcat tgtaataagg gctttttcca tcgtaggcat 1157101 gggtttccgc cttggcgggt gcacctttga cggcaaaaac aaatactact gcgaataaca 1157161 ccaatgaagc cttcataaac agtcttttca atttatgacc tccttaatat ggcaaacaat 1157221 aaatcatatg gaggaacaat caaaacatgc atgctttttt gtgaacaata aaggcggccg 1157281 ggaggatgga gttcttggcc gcctctggta tgaggttatg cttttacatc aatggtttgt 1157341 ccgagagttg gatgttgaat catctttaag gtttgatcgg cattttgctg ggcggtgtcc 1157401 agcctttttt tcgttaaagc aatatttaca ttctgggcaa gggatgcttg atgcatcgca 1157461 accgataaag caggaatatc catggttcca cctcctatgc cttacctatc ggcgggtttg 1157521 tatgatttta cagtgaaaaa tggcttaatt tctcttgttg acccttacgc tgcggcatat 1157581 cgtatgtttt tgacaaggag ggaatcagga tgaatctagt aatggaaaag acctttgagc 1157641 aatacgaaaa gctgttttca atggaagaac agaaaagaga agatgtattt cggtatacga 1157701 tgatgaggcc gtttgaaaag atgtggaccg ccatccaagt tccgctgaaa gcgaaggagc 1157761 caaacggcta tgatgtgatc atggctgcga aaatgctggg ctatttggat gtccgtgatg 1157821 ctgaaagcgg ccagaaagca ctacaaatac tgaaagaatc acatgtttca gagacagctg 1157881 aatctgcact tcggcaatgc atattttttg ctgagcgcga acagctgcgg gtgaatgcaa 1157941 aggagatcaa attcggcctt tatatcgctg atccaaataa gcttcagctg caaaaaggct 1158001 actgcgggtt tggcgggata ccgggcttta ttcatgtatg gattaatccg aacagttata 1158061 acctgccaag gattccttcc attattgctc atgagtttca tcataatgtg cggttttcgt 1158121 atatagattt tcatcatggc tctgtaagtg tcggggatta tcttgtgatt gaaggattgg 1158181 cggaatcatt cgccagagag ctgtttggta cggaacgatt gggcccttgg gtaactcgtt 1158241 ttgatcatga agacttgcaa tattccattg atgtgattaa tgaggtgctg gatgtgaaag 1158301 gattttcgga agtcagccgt tatatgtttg gtgatccaat tgctaacgac caaggcttta 1158361 agcctgcagg tttatcggct tttgcgggtt atgcagttgg ctatcatgcc gttcagtcat 1158421 ttatgaatca acatcatatc acgataagcg aggccacacg tttggatgcg aagaccatta 1158481 tttctcaatg cggtctgttt tctacatgaa aaaagcgtca catacagcgg cgctttttga 1158541 ttcccaaaac cagcagttct atggcggcac aggcggcaat tccgattgta tatgcttcga 1158601 tatcgctcca taaaaaaccg taccctagta caagcccgcc aagagaagta tctctaatct 1158661 ggtcgatcca ttcggcatga tagagctggc tgaattcaat gacaaaacag aaagaaagac 1158721 tgataatgcc cgttatcatt gtcttcagct tccgaaatag aaatccgcat cccgtgaaga 1158781 tcatggcggc ccacaacgag tctcccagat aagtattgag ggtatcagga agaacactgg 1158841 agaatgctct ggatccaagc cccagcccaa tgatcagtat ggtgaaaact gcatatatcc 1158901 aacgatttcg cttcattgcg aattgatacc ccgtctctgc ttcatctccc tgtattgtaa 1158961 ggaatatagc ttttatttgt ccactaaaaa agcggctgaa tagccgcgta gggtgtttat 1159021 tttgctttta ggtttacatg gtcggctgtc tgatccgtgc ctattacaaa atggagttca 1159081 tagcggcctg tatcatatac ataatcgatt tcatcggtaa acgggacggt taacacccga 1159141 tttactggtc ctaattgctt ctgcagcact tccggcgtaa ctccgcctaa attcagctgc 1159201 cgttccacac cggttccaaa gtagcggatt tctgaaattg tcatgtcttt atgataggaa 1159261 aatccgtagc ccggctgtcc catattccag tgatataaat caaatcgatt gtctcccccg 1159321 actggtcttt ccggttcccc aaacgcagcg tggacatccc cttttgtgct tttgttaatg 1159381 gtaaggcctt gcgcctgctg aggcatttcc cctttatagg cggtgttata gaggtttttg 1159441 acaagctcag cggctgattg attcgtgttt tctgagagtg tgtttgtttg agctgcggcc 1159501 tttgccggtg ctgaaaagga cgcagcccca aagccggtaa aacagcttgt tactgctgct 1159561 gccgcggtta tagcagacat tgtctttttc atgttaatcc ctcctaattg atctaccatt 1159621 ccgtttcccc gtgtttttgc aacgaaacat gtgagtgcgc tttgtatgtt ttattgagtt 1159681 gttgtaaggg aactgaaata ggtaattcgg tatataaagc aagaaagggg aatggagatg 1159741 gctggcaaga aaacaatcac aataaacggc gttgaaatgg aagcgtccga ggaacagacg 1159801 gtgctgcagc ttttgaataa cagctcgatt gaagtgccgc aagtttgcta tcatccaagc 1159861 ttagggccga ttgagacatg tgatacgtgc atcgtcagca tcaatggtga gctgaagagg 1159921 tcgtgctccg ctgaattaaa ggatggggat gtcattgata cgctctcacc tgacgtgaaa 1159981 aaagcgcagg tcatcgggat ggacaagatt ttatataatc atgagcttta ttgtacagtt 1160041 tgcgattaca acaatggggg atgcgaaata cataatacgg tgaaggaaat gaaaatcaat 1160101 caccaaagca ttccgtttga tcacaagcca taccataagg atgaatccca tccgttttat 1160161 cggtatgatc cagatcaatg tatattgtgc ggacgctgtg ttgaggcatg ccaagacgtt 1160221 caggtaactg aaacgctgac cattgactgg gagcggaaac gcccgcgcgt catttgggat 1160281 aacgacgtgc cgatcaatga gtcgtcatgt gtgtcatgcg gccattgttc aacggtctgt 1160341 ccgtgcaacg cgatgatgga aaaaggaatg gaaggggaag ccggatattt aacaggcatc 1160401 aataacgaaa cgctgcgacc gatgatcgag atcacgaaag gcgtagagac aggctacggc 1160461 tcgattctcg cgatttctga tatggaatcg gccatgcgtg atgaacgaat caaaaaaacg 1160521 aaaaccgtct gcacgtattg cggcgtcggc tgcagctttg atgtctggac aaagggcaga 1160581 gacattctga aagtagagcc gcaggaggaa gcgcctgcca acggcatttc tacttgtgtg 1160641 aaaggcaagt tcggctggga tttcgttaac agcgaagaac gcctgacaaa gccgctgatc 1160701 cgtgaaggcg atcatttccg tgaagcagag tgggaggagg cgttattgct gatcgccagc 1160761 aagttcactg aattaaaaga ggcgtttggc ccggattctc tcgcttttat tacatcttct 1160821 aaatgtacaa atgaagaatc ctatcttatg caaaagctgg ccagaggggt cattggcaca 1160881 aataatgtgg acaactgctc tcgctattgc caatctcctg cgactgccgg cctgttccgg 1160941 acagtcggct atggcggtga ttcaggatca attacagata tcgcgcaagc ggaccttgtt 1161001 ttgattatcg gttcgaacac gtctgagtcg catccagtct tatccactcg gattaaacgg 1161061 gctcataagc tgagagggca gaaagtgatc gtcgcggata tcagaaagca cgaaatggca 1161121 gagcgctcag atttatttgt ccagccgcgt gccggatcgg atatcgtctg gctgaatgcg 1161181 atcgccaaat atttaataga aaacggcaag gccgatgaac gatttttgag agaaagagtg 1161241 aacggacggg atgaatatgt aaaaagcctc gcgccgtaca cacttgaata tgctgaggag 1161301 aaaaccggga ttgatcaaga aacccttatc caaatggcag agatgatcgg gcaagctgac 1161361 agtgtgtgcg cattgtgggc gatgggcgtg acacagcata ttggaggaag cgacacgagc 1161421 acggcgatct ctaatctgct gcttgtgaca ggaaactacg gaaaaccggg agcaggttct 1161481 tacccattgc gcggccataa caacgtgcag ggagcaagtg actttgggag tatgcctgac 1161541 agactaccgg gctatgaaaa agtgacggac gaacaagtcc gccaaaaata cgagcgtgtg 1161601 tggggtgtgc cgctgccgaa ggagccgggt atgaccaacc acgaaatgat tgaaaaaatc 1161661 cattccggac agttgaaagc gatgtatgta aaaggtgaag aaatgggcct tgtcgactcc 1161721 aatatcaatc atgtacacgc tgcatatgaa aagcttgatt tctttgtggt gcaggacatt 1161781 ttcctttcac gtacagcgga gtttgctgat gtggttcttc ctgcgagccc gagccttgaa 1161841 aaagaaggaa cgtttacaaa cacagaacgc cggattcagc gtttgtatca ggtatttgaa 1161901 ccgctgggtg aatcaaagcc ggattggcag attattatgg aggttgccaa taagcttggc 1161961 gccggctggc tctatgagca tcctgcagac attatggagg aagcagccaa gctgtcgccg 1162021 atttatgccg gtgtcaccta tgaacgtctt gagggctata attccctgca atggcctgta 1162081 aacgctgatg gaaaggattc gcctttactc tttacagagc gcttcccttt cccagacggc 1162141 aaggccattc tctaccctgt ccagtggaca gagcctaagg aattcggtga ggaatatgat 1162201 atccatgtca acaatgggcg gctcttggag cacttccacg aagggaacct gacttacaaa 1162261 tcaaaaggga tttcggagaa aacaccggaa gtgttcttag aaatttctcc tgagcttgcg 1162321 gcagaacgag ggattcagga cggaaccctc gtcagactca catcgccttt cggaaatgtc 1162381 aaagtgaagt gcctgattac tgatcgagtc aaagggaagg aagtatatct gccaatgaac 1162441 gattcagggg aagcggcgat caacctgtta acaggcagcc atgccgataa ggataccgat 1162501 acgcctgctt acaaagaaac atcggccaag atggaaattt tgaagcacga cggaatcagc 1162561 ccgctgccta agatcaacca ccgcaacggc aatccgcagc cgcaaatcgg tgtgcaggtt 1162621 cataagaaat gggcgcggaa ggattatatt ttccctggtg acgctgtgaa aagggggatg 1162681 ggccataatg gctaaagcga ttaaacgaat ccaaaaaatc gaggtaacag aagaggatca 1162741 gcgaaagcgt gatttgcggg aaattgaaga tgctctaatt gaccacaaag aagcgattct 1162801 cgaaacattg catatgctgg gccatatgaa cgagcgcggg gtcctgccgt tgctccgcgg 1162861 cctttttggt caaggggata aagttcttga tatcctggtg aaaaaggcag atacagagga 1162921 aacagccaat acgctgaaaa atctgcttct tctgtttgga acactcggca tgctggacgt 1162981 gaagcagctg gagcctctca ttttgaaagt gaatgcgggt gtggcaagcg ctgtagagca 1163041 gaaaaacagt gaagaaaaga caggttattt tgatattatc cgctcgctaa aagacccgga 1163101 aatcaacaaa tcaattacac tgctcttttc ctttttaaaa ggaatgggac aagatacaaa 1163161 ggagctggaa cgcacgacgc agcctccgga acaccaaaaa catcatcagg aaccccgaga 1163221 gaaaagagga atgaataagc gagattgacc tcccacccga gcggcttcag ccagctcggg 1163281 ttttttgatg aaaaggtcta atggactagt aaaaaatatt caaatactag gaagaagtaa 1163341 gattgtgatg aatgagatag aaataatcgt tactttctta cctgttaaga aaagggaaaa 1163401 tctgattata atagaaatcg attactttag atgggggaac aatcatgaaa aaagtcttat 1163461 tactattatt tgtcttgacg atcgggttag cgctttctgc gtgcagccaa tcgagcgatg 1163521 cgtcagagaa ggaaaaaccg aaagagaaaa aatcgcaaga agagcttgaa aaggaacttg 1163581 ataaggaatt gaaaaaaggc ggtgagccga agaccaaaaa agatgatcaa atacataaaa 1163641 taggagaaac atttaaagca ggacatacga attttacagt gaataaagtt gatagagtgc 1163701 aaaaaggtga atatatgaat gttggcggag ctgtaaatga ggagacaaaa acaataaaag 1163761 atgatgagga acggcttatt atagaagtta cgatggaaaa tataggggaa gattcaataa 1163821 gctacaattt tatcgggttt gatttaagag ataagaatga tcaatcagtg cggcctgttt 1163881 tttctataga agagaagggc agaatcctta tgggaggaac actagtatcg gggaaaaagg 1163941 ttacaggtgt actcagttat gtcatcccta aaggagaaca gaaacattac acactggtat 1164001 ataatccgtt tttagctgat acaaatagca gtaatacaga agagagagta aaggacgata 1164061 ttgattactt ggtgaagtta gattagatgc taatttacag ttgcacgttt ttcatctgtg 1164121 gaaaacgtgc attttttata gcgaaacttg acttgaaagg atgagtgata aaagtgcaaa 1164181 ccaaatggct ggaacgggca cagcggattc gggcgatcgc ccaagcgggg cttgcttttt 1164241 ccaaggatgt gtacgacagg gagaggtacg aagagctaat gaagcttagc gcggaaatga 1164301 tggcggatta ctcggagaag gacattgaag ttatcactga tttatggcaa ggcgagaagg 1164361 gctatccaac accgaaagcg gatgttcgcg gcgctgtatt cagagagaat cagattttgc 1164421 ttgtccggga gaagcatgat gagctgtggt cgctgccggg cggattttgc gagattggtt 1164481 tatcgccggc tgaaaacgtt gtcaaggaaa tcaaagaaga gtcggggtac gatacagagc 1164541 cgtctcgatt gctggccgtg ctagacagcc ataaacactc tcatccccct cagccttatc 1164601 actattataa aatcttcatc gcatgcagca tgacggacgg gcagggggaa acagggatcg 1164661 agacgaatca tgccgctttt tttccggaag acagactccc gccgctttct cctaaacgaa 1164721 acacaccctc acagcttagc atgctgtttg actttttgcg ccatccggac aagaaaacga 1164781 tatttgacta aaaaagaaag agcctgtggg ctctttcttt tttataatgt aatgtgtttt 1164841 tcgttggcga gtttcagaag ggtcaaaata gaatcggctt gtttatggcc gagtttttgc 1164901 tttaatttgt tttcttcaac taatcggctg ccataaattt tgacggaggc tttgtcgacg 1164961 acagtatgcc agttttcctg tttttttccc tcaacaagcg gtttttcatg tctctcagaa 1165021 aaagagaaca caaagagtac gaatgcaagt gaaagtagga ttccgacaac ttgttttttg 1165081 taatcagtct gtgctgccac gttgttctct ccttcacctt ttaccttcta tttaatcata 1165141 gaaccaaatt attttacata atgggaaagt catttttgga gttagtgcat ttggttgaaa 1165201 acagagacgt tttttgagcg gagcggtgca attgaatcca tattggattt gcgtgcttat 1165261 gcctaaggtc acgttgtgag ccaaaacagc agtgcagaat agaaaaaaat tgaaagatta 1165321 tggtaagatg aacgaaattc gagggggaat atatgatgcc tgcatcgaac atcgtgatcg 1165381 cctgcctgct gttatcaatt taattatttg tggtagtccc tctctttttc gaaagcggga 1165441 ggtgaagtgg aacattaatt gctgaattct ttcaagggga gtgaccgtac atgaatgtgt 1165501 taaaccgccg gcaagccttg cagcgagcgc tgctcaatgg gaaaaacaaa caggatgcgt 1165561 atcatccgtt tccatggtat gaatcgatga gaaaggatgc gcctgtttcc tttgatgaag 1165621 aaaaccaagt gtggagcgtt tttctttatg atgatgtcaa aaaagttgtt ggggataaag 1165681 agttgttttc cagttgcatg ccgcagcaga caagctctat tggaaattcc atcattaaca 1165741 tggacccgcc gaagcataca aaaatccgtt cagtcgtgaa caaagccttt actccgcgcg 1165801 tgatgaagca atgggaaccg agaattcaag aaatcacaga tgaactgatt caaaaatttc 1165861 aggggcgcag tgagtttgac cttgttcacg atttttcata cccgcttccg gttattgtga 1165921 tatctgagct gctgggagtg ccttcagcgc atatggaaca gtttaaagca tggtctgatc 1165981 ttctggtcag tacaccgaag gataaaagtg aagaagctga aaaagccttt ttggaagaac 1166041 gagataagtg tgaggaagaa ctggccgcgt tttttgccgg catcatagaa gaaaagcgaa 1166101 acaaaccgga acaggatatt atttctattt tagtggaagc ggaagaaaca ggcgagaagc 1166161 tgtccggtga agagctgatt ccgttttgca cgctgctgct ggtggccgga aatgaaacca 1166221 ctacaaacct gatttcaaat gcgatgtaca gcatattaga aacgccaggc gtttacgagg 1166281 aactgcgcag ccatcctgaa ctgatgcctc aggcagtgga ggaagccttg cgtttcagag 1166341 cgccggcccc ggttttgagg cgcattgcca agcgggatac ggagatcggg gggcacctga 1166401 ttaaagaagg tgatatggtt ttggcgtttg tggcatcggc aaatcgtgat gaagcaaagt 1166461 ttgacagacc gcacatgttt gatatccgcc gccatcccaa tccgcatatt gcgtttggcc 1166521 acggcatcca tttttgcctt ggggccccgc ttgcccgtct tgaagcaaat atcgcgttaa 1166581 cgtctttgat ttctgctttt cctcatatgg agtgcgtcag tatcactccg attgaaaaca 1166641 gtgtgatata cggattaaag agcttccgtg tgaaaatgta atagataagg agactggaga 1166701 ttcatgaaaa agtaccatat ttcgatgatc aatatcccgg cgtacggaca tgtcaatcct 1166761 acgcttgctt tagtagagaa gctttgtgag aaagggcacc gtgtcacgta cgcgacgact 1166821 gaggagtttg cgcccgctgt tcagcaagcc ggtggagaag cattgatcta tcatacatcc 1166881 ttgaatattg atcctaagca aatcagggag atgatggaaa agaatgacgc gcccctcagc 1166941 cttttgaaag aatcactcag cattctgccg cagcttgagg agttatataa ggatgatcag 1167001 cctgatctga tcatctatga ctttgttgcg ctggctggta aattgtttgc tgaaaagctt 1167061 aatgttccgg tcattaagct ctgttcgtca tatgcccaaa atgaatcctt tcagttagga 1167121 aatgaagaca tgctgaaaaa aataagagaa gcagaggctg aatttaaagc ctacttggag 1167181 caagagaagt tgccggctgt ttcatttgaa cagttagctg tgccggaagc attaaatatt 1167241 gtctttatgc cgaagtcttt tcagattcag catgagacgt tcgatgaccg tttctgtttt 1167301 gtcggcccct ctctcggaga acggaaggaa aaagaaagcc tgttgattga caaggatgat 1167361 cgcccgctta tgctgatttc tttgggtacg gcgtttaacg catggccgga attttacaag 1167421 atgtgcatca aggcatttcg ggattcttca tggcaagtga tcatgtcggt tgggaaaacg 1167481 attgatccag aaagcttgga ggatattcct gctaacttta ccattcgcca aagtgtgccg 1167541 cagcttgagg tgttagagaa agctgatttg ttcatctctc atggcgggat gaacagtacg 1167601 atggaagcga tgaacgcagg tgtgccgctt gtcgtcattc cgcaaatgta tgagcaggag 1167661 ctcactgcaa atcgggttga tgaattaggc cttggcgttt atttgccgaa agaggaagtg 1167721 actgtttcca gcctgcagga agcggttcag gctgtatcca gtgatcaaga gctgctcagc 1167781 cgcgtcaaga atatgcaaaa ggatgtaaaa gaagctggcg gagcggagcg tgcggcagct 1167841 gagattgaag cgtttatgaa aaaatccgct gtcccgcagt aaaaacataa aaaccgaaat 1167901 caatttgatt tcggttttct gtttaaatat tttttttcat cccgcatctc cggcattctc 1167961 taagaaattt tccgcctttt acagagcttt tgaacagtgt gtaatcacag ttgtcgcagc 1168021 gcccgctgcg ggcatccgga tattcattga attcgtaaac aatcgatgta tcgtagcctt 1168081 ttgtttcata ttcttctttt ttggtttcca tgtcgatcct ccgttacaag acgtgtctgc 1168141 tgtttatctt acagcaagct tccggcgtat tcaatggatt ttaggaggtt gggtttatct 1168201 tgatttctcc cttggtttgc gccaaaatag ctttattaag cttatataca taaaaagcct 1168261 atgcaaagag gagaggaaac gggtatggga aaagggttac ttggaaaacg cgtggcaatc 1168321 ggtggctcac gaaaaacgga agaaattagt acaatcattg aaaaacaggg cggaatacct 1168381 gtcatccggc ctctccaagg tacagtttac ttagcagaga agcaggtgga gccggatttg 1168441 cggacgtttg cggaagaaaa agctgactgg gtcattttca cgacaggcat cgggttggag 1168501 actcttgtcg atatggcaga gaaaattgga ctgaaagatg agtttctgca ggccattcgc 1168561 caagcgaaag cggcatgccg gggatacaaa acgctgtctg cgctgaaaaa gcttggaatc 1168621 acaccggaag cttcggatga agacgggaca acaagaggct taatccgttc cttggagcct 1168681 cacgactttt caggaaaaac agtcatggtg cagcttcatg gcgaaaaagc gccggctctc 1168741 atggcatttc ttgaagaaaa aggcgcgtct gtcctgccga ttctgcctta tcagcacatc 1168801 ccgccggagg aggaaacggt ggagcggtta tgccgagagc tgatgaacga tgaggtcgat 1168861 gccgtttgtt ttacaacggc cattcaggtt cgttccctgt ttgattttgc caaggggcga 1168921 ggttatatca atgaagtgaa gaaggtattc gaagaacgcg ccatcgcagc tgctgtcgga 1168981 aaagtgactg ctgaagcact gcgggaagag ggcattacga gactgcttgc gccagagatt 1169041 gagcggatgg gtgcgatgat tgttgagctg gccaagtatt atgaagaaaa ggaataacaa 1169101 gtacaaaaag ccgcttttcc ctcggaaagc ggcttttgtc tgtcattcat tttgcttcag 1169161 ctgctgatga acggtgaata atgatgggta tgtcagcacg cttaagatta cacaagtcag 1169221 cgcggctgag gccatcgttg taaacacgat taagagttga aagcgtactg cctgaatcgg 1169281 gtccgcgccg gctagaatct ggccagtcat catgccggga agctggacaa gacccagtgt 1169341 tttctggctt tcgagcgtcg ggatcatact cattttcatc gctgaggtaa gaatgcgctg 1169401 tatggattgc ttcggtgtgc cgccaagtga caatattaat tgaatttctt ctttgcgaac 1169461 gccgacttct gagttaagcc ggtttagaaa caaacttgag agcaccatcg aatttccgat 1169521 gaccatcccg ctgatcggaa tgacatatcg tgccgtaagc ggaatgatat gaagagacag 1169581 cagaattccc tgcgtcacaa tttctacgat tgctaacgcg gcaaacaccc tccaaaacga 1169641 accgatagta tttttctttc gcttgatgac attttgcgcc gccaccgcga gcattaacag 1169701 caccatcagc aggataaaaa cagggtggtc tccgcgaaaa atcagcgaca aaacataacc 1169761 gatgataagc agctgcaccg cggcccggat ggtggcgatg atcatgtctt tttctacacc 1169821 ggctttaaag gattttgata aaaacaaggc gatcaaaaca aagatcatcg ttaaagagag 1169881 agaaaggtaa tccattaccg agtgcctccc ttcaaaaatt ctttcgctgc ttcatgctgc 1169941 ggagcggaga aaaatgtgtc ggtttcagcg atttcaagca gccggccatc tgccataaac 1170001 caaatggtat cggctattcg ttttgcctgc tccatattat gagtgaccca catgactgtc 1170061 cattttttct cttgatgctg acgtttgatc agttcttcaa tctcaagagc agagaccggg 1170121 tccaaggccg atgtgatttc gtccaacaat agaatggagg aaggatttga gagcgttctg 1170181 gccagtgaca gtctttgccg ctgcccgccc gataagtctc tggcgcttct gtctaacaac 1170241 tctggcggca gccctgcaag cgaagccagc ttttcaggag agtacagctg ggattgatgc 1170301 agcctttgta caagacttaa attgtcacgc actgtcccgt cgagcacggg agccgattga 1170361 aacgcgaggg ctgccgttcg cctcagctca ttgacattcc attctctgac ttcctttccg 1170421 tatatgttga cttcgccgct gtcaggcgtt ctcattaaat tacacataga aaggagggtg 1170481 cttttgcctg agccggaagg gcctaaaacg gctacgattg caccctgttg aatgtctccg 1170541 gtgacatcct gcagcacatc ataggtttgt ccatcttgtt tatagctttt tctgactgat 1170601 ctgaaggaga tggctggtat gttttgtgtt tgatcgtttg cttccattac aataatcacc 1170661 tttcaatata agtaggctga cattatattt aactataacg tgaaacagat tccttttggt 1170721 agcacaaata aaggagaaca ggctttcacc cattctcctg cagatgctac gcagtcagat 1170781 ttgactgtgc tttctttttc ggttttctcg gctgtgaagc gaaggtatgt aacatcatcc 1170841 ccgctattat aatgaacaaa ccggcaaatg ataatagaga tgggaaaacg cctgacagca 1170901 gaacaatttc accaagcagc gcgaaaatca cttcaccgga ttgagtggct tcaacagctg 1170961 cgagtttttg cggattgtct cttaccatat cagtggccca gaaaaataaa accgtcgcaa 1171021 tgatgcctga gctgacggca acgataaagg attgaacggt ttgacttgct gttggaaggc 1171081 catctgacca ccagccgtaa gctgctaata taagccagaa tggaaggctt gccaatgtca 1171141 ttccaagcac gcgctgaaat gtatcaagcc ggcctccgta ttcttcgagc attcttcggt 1171201 ttcctaacgg ataggcaaaa gccgcaatga caaccggcag cacactgaaa agcagcatcc 1171261 tcccagaaag cgattctgca tgctgaagct gaatcagagc cgctccaatc aggatgatca 1171321 cagaagtgcc aagtgaaacc aggggaatct tttggcgaat gagctgcgga ccgcccggca 1171381 tatcttgttt gacataaaac aaaggagata agagcacccc ggctacaatt gtaatttgcc 1171441 aggttccagc tatgagccac cccggaccgt atgcagccgc aaatgtaatc ggtgcgtaaa 1171501 aaagcacgaa accgacgaag ctccatttga tccaataaaa cggctttttc ctcatttcta 1171561 gtaagagagg cgtgaatgtc cctctcatga tgacaatcaa acataaaaat ggcaccataa 1171621 aaataaagcg cagcgaagag ctccaaagcc agctgcctcc tgataactcc atcgctctgt 1171681 ttaatataaa ggtaacggcg aaaaagagtg aagccaatat tccgataacg atagctttca 1171741 tgatatccct cattctggca ttattttttt atactatact attcggtatc atgcagatca 1171801 atggaatcat gagaaaaaca tcatgtttgg cgaaccgcta tatgtggaag acaaaaaagg 1171861 gaggtgaaat tgatggaaag agagacacag acatacttct ttccggatga cggcaggatt 1171921 ccgaatcacc ctgattttcc gctcgtggtg tatcaaaacg cgcttaagga caccggactg 1171981 gcagagcgga tcgtcacccg gcatggctgg tcaaacagct ggtcagggag tgtttttcca 1172041 taccatcatt atcacagcaa tacgcatgaa gtcctgattg cccttaggag agaggctgtg 1172101 attcagtttg ggggagaaaa aggggctgcc atccctttca aatcaggcga cgcagtcgtg 1172161 attccagccg gagtcggaca taaaaagctc agctcaagcc ccgattttac tgtccttggc 1172221 gcctatcccg gtggcgttca gtacgatatg aagacgggga agccgaatga gcgggaggaa 1172281 gcggtcaaac agattaagca ggcggcgttg ccggcgaatg atccgatcac aggaaaaaga 1172341 gagcctctat tggaaatatg ggtaaagtga aggggagaaa ttgctggatt gtcaataact 1172401 agtgccgcag aaacgatatg acatgagctc catataaatt aatttcataa tcgaagcaat 1172461 tcacgttcaa attttgttca aaaagtgtta tcatatagaa ggtaatcgaa ttggagtttt 1172521 ttgtgtttgc tattttcaga gagagtaaag gattttgact tattcaattg tttattttta 1172581 gataaaaata atactgaata tggcaagatg aaaaactggg tagtaaacat ttatttttgt 1172641 aaatgattgt gcatgaattc acaatcctta ttcttatgcc ttaaaagcgt gagacaggga 1172701 gaggcactac cctttccaaa aaaatcagca aactgcttat agtaaaggag aattggatat 1172761 gccagaaaca atcgatcaaa caaatgcgtc tgtcagccaa agccagcaag atcttattga 1172821 tcagctatta aagccagaag ttcaagaatc attgactgtt ttagttgacc agcttccgaa 1172881 gctgactgag ttagtgaata ttttaacgaa gtcttatgat ttcgctcagt ctgtagcgac 1172941 tgacgaagtg ttaaagagcg acacagtcgg tgcgatcact gaaattctcg agcctgtaaa 1173001 agaaacagcg aaagaagtag ctgcgactgc gatcgaagca aaagaccgcg cggaagcaag 1173061 caacgaaaca attggacttt tcggccttct tcgcatgctg aaagatcctc aagctcaaaa 1173121 gctgttccgt tttgctaaca gctaccttga agtcatgaac gaacgcgaaa accaaaaata 1173181 atctcagatt caaattgata taaaggacgg aggatatacg atgtcaaaac atattgtcat 1173241 tctaggcgct ggttatggcg gagttctttc tgctctaaca gttcgcaaac attacacaaa 1173301 agaacaagca cgcgtgacag tggtaaacaa atacccaact caccaaatca ttacggaatt 1173361 acaccgcctt gctgcaggca acgtgtctga aaaagcggtt gcaatgccat tagaaaaact 1173421 tttcaaaggc aaagacattg atcttaaaat tgcggaagta agctctttct ctgttgataa 1173481 aaaagaagtt gcgcttgctg acggttctac attaacttac gatgcgcttg ttgtaggtct 1173541 tggttctgta acggcttact tcggcatccc aggtcttgaa gaaaacagca tggtattgaa 1173601 atctgctgcc gatgcgaaca aagtcttcca acatgttgaa gatcgtgtgc gcgagtactc 1173661 taaaacgaaa aacgaagcag atgcaacaat ccttatcggc ggaggcggct taacaggtgt 1173721 tgagcttgtt ggtgagcttg ctgacatcat gccgaacctt gcgaaaaaat acggcgtaga 1173781 ccataaagaa atcaaattga aacttgttga agcaggtccg aagatccttc ctgttcttcc 1173841 ggatgatctt atcgagcgtg cgactgcaag ccttgaaaaa cgcggcgttg agttcttaac 1173901 aggtcttcct gttacaaatg tagaaggaaa cgtaatcgat ctgaaagacg gatctaaagt 1173961 tgttgccaac acatttgttt ggactggcgg cgtacaaggt aacccattag tcggtgaatc 1174021 aggcctagaa gtgaaccgcg gacgcgcgac tgtaaatgac ttcctgcaat ctacatctca 1174081 tgaagatgta ttcgttgctg gagacagcgc agtttacttc ggtccagacg gccgtccata 1174141 cccgccaact gcacaaatcg catggcaaat gggtgagctg atcggttaca acctattcgc 1174201 ttacctagaa ggcaaaacgc ttgaaacatt caagccagta aactctggta cacttgcaag 1174261 ccttggacgc aaagacgcgg ttgccatcat tggtgctaat tctacaccgc ttaaaggtct 1174321 tcctgcttcc ttgatgaaag aagcaagtaa tgtacgatat ttgacacata ttaaaggact 1174381 tttcagcctg gcttactaat ccttttaatg aatctggcat tgccaaaagc attcctttcc 1174441 gagtgctttc tggcaatgtc tttttttatg tttatgacag cgttaacatt tcattttcaa 1174501 aaaagagatt gatcccaaag gaatataaag gtaaaataaa aacaaatcaa aatgttaacg 1174561 ttaacatttt gaaatagaat gaaagacggt gaggacatgg aacccttcat gggcaaaaac 1174621 tttttattga aaaatgaaac cgctgtcagc ctctatcaca attatgcgaa agacatgcca 1174681 attattgatt accactgcca cttaagtccg aaagaaatct atgaaaataa gacatttcaa 1174741 aacatcacgg aagcctggct gtatggtgac cattataaat ggcgcatcat gagagccaat 1174801 ggaattgagg agacatacat taccggagat gcgcctgatg aggagaaatt tatggcttgg 1174861 gcgaaaaccg tgccgatggc gattggcaac ccgctctaca actggactca cttagaattg 1174921 cagcgttttt ttggcattta cgagatttta aacgagaagt ccgggtcggc tatatggaaa 1174981 cagacaaata aactgctcaa aggggaaggc ttcggggcaa gggatttaat cgtgaaatca 1175041 aatgtaaagg tcgtgtgcac cacagatgac cctgttgatt ctcttgaata ccatttattg 1175101 ttaaaagaag acaaagactt tcctgtcagt gtgctgcctg gatttcggcc ggataaagga 1175161 cttgagatca atcgtgaagg ctttcctgag tgggtgcagg cgcttgaaga tgccgctgcc 1175221 atatcgatta caacctatga tgagttttta aaggcgttgg aaaaacgagt gcgattcttc 1175281 cactcagccg gcggcagagt ttctgatcac gcgatagata caatggtatt tgccgaaaca 1175341 acaaaagaag aagctggacg gattttttct gacagattac aaggaacaga ggtttcttgt 1175401 gaagatgaga agaaatttaa gacatatacg cttcagtttc tttgcggttt gtatgcggag 1175461 ctcgattggg cgatgcagtt tcatatcaac gctttaagaa acacgaatac aaaaatgatg 1175521 aaaaggctcg gacctgatac agggtatgat tcaatgaacg atgaagaaat tgctaagcct 1175581 ttatacaagc tgctgaactc agttgagatg aagaaccagc tgccgaaaac gattttatat 1175641 tcactgaatc caaatgataa ctatgtcatc gccagcatga tcaacagttt tcaggacggt 1175701 attaccccgg gaaaaataca attcggcaca gcctggtggt ttaacgatac taaagacgga 1175761 atgctcgacc aaatgaaagc gttatcaaat gttggccttt tcagccgttt tatcggcatg 1175821 ctcaccgatt ccagaagctt tctttcgtat acgcgccacg aatatttcag gcggatcgtc 1175881 tgcaatttga ttggagaatg ggtggaaaac ggcgaagtgc cgcgcgatat ggagcttctg 1175941 ggaagcatcg ttcaggggat ttgctatgac aatgcgaaac actactttca atttcaagaa 1176001 gagaaagcaa acgtgtaaca aagtgtccgc tcagtatcgc tgagcggatc actatccgaa 1176061 aattcttaag acacagaggt ggaacatgcg aactgaactg gcaaataagg ttgtgtcggt 1176121 cgaaacggaa aaaaggcttt cattgaaaga gaaaatgtcc tatggctttg gtgattttgg 1176181 caacggtttt atgtttgatc tcggccagat ttatttattg aagtatttca ctgatgtagc 1176241 gggaatcccc gctgcgatgg ccggcggcat ttttttagtc agtaagctgt ttgcagcgat 1176301 aacagatcca attgtcggct catcaatcga ttatcgcaaa aacatcggca aacgggggaa 1176361 attcaggcct tatctattaa tcggcagcat cgtgcttgcg gtgcttactg ttcttatttt 1176421 tctgtctccc aatgtatcaa cgaccggaaa actgatatat gcatatgcat cctatatgat 1176481 ttggggcatc ggctattcgt ttgtgaatat tccgtacggc tcattagggg cagcgatgac 1176541 tcaaaattct gaggaccgga cctccatttc gacgttccgc caaatcggat cacttggcgc 1176601 cttgtttatc acaagtgtgg ccgtgatgcc gctgctcgtc aagtttgata atccgaaggt 1176661 cggctacccg gtggtcatgg gcttgttcgc cgcgctcggt gtgttttggt tttatatttg 1176721 ctaccgcaac tgcaaagagc gcattatcat atcggaagca cccaaagaaa aattaacact 1176781 ctcatctgtc gtcaaaacat ttattacaaa taaaccgctg ttaacccttg tcctgatgac 1176841 gattttttca atttccgcat acaacattaa atccgccatg ctcgtctatt tcgcacaata 1176901 taacttgggc aatgttgaat taatggctta tatgaacttc atcattattg gttcttcctt 1176961 tttgggcgtc gtattccttc caaagctcgt caagatgttt ggaaagaaac gaacggcaat 1177021 gatcggcttt ggcatcagtg tggccgcgga tctgatcaac tttatgcttc catctaacgt 1177081 ttatgtgttt acaattctcg ccagtatcgc ctttatcgga atcagtatcc caaatggcat 1177141 cacgtgggct cttgtctccg atattatcga ctatggcgaa tggaaatccg gtgaacggaa 1177201 ggaagcaacg acatattcac ttttcaattt ctcaagaaag cttgctcaat ctttgtctgg 1177261 ctttctctcg gggatcggtt tggggattat cggctatgtg ccgaatgcag tccagacagc 1177321 acaggcgctg attggcatca aagcgctgct tcttctgtat ccggccattg ctttggcatt 1177381 agcgatgttc attatcggct ttctttataa actcacagac cagcagcatg ctcagatcgt 1177441 tcaggatctt catcaaaaga gctgacaata taatataaag aatatttaaa ataatttgta 1177501 aataaaatgt gtttgtaggg gtttcgcttg gagagtgccc aaaaaactga aaaggaagga 1177561 ggcacttgct tgaaaacgat aacaattgca gctgaagaag caaaggaact cgtttggcaa 1177621 aagctggacg gtgccggttt gaatgaacga gatgctgaaa aagtggcaga tgttctcgtg 1177681 cacgctgatt tgcgcaatgt acattcgcat ggcgtgctgc acacagaaca ctatgtgaac 1177741 aggcttttag cgggagggat caatcctggg gcacagcctg tttttaaaga gacggggcct 1177801 gtgaccgggg tgcttgacgg agacgatggt ttcggtcatg tgaattgcga catggcgatg 1177861 gaccatgcaa ttgacatggc gaagaaaaaa ggagtcggca tggtcacggc cgtaaacagc 1177921 agccattgcg gagcgctaag ctattttgtg caaaaagcgg ctgacgaaaa gctgatcgga 1177981 atggcaatga cgcatacaga cagtatcgtt gtcccatttg gggggaggac tcctatttta 1178041 gggacaaatc cgattgctta cggagttccg gctaagcata aaaaaccgtt tatcctagat 1178101 atggcgacat ccaaagtggc ttttgggaag attctgcagg cccgtgaaga gggcaaagaa 1178161 attcctgaag gatggggagt cgatgaaaac ggagaagcag taactgatcc tgacaaggtc 1178221 gtctcacttt caacattcgg gggcccgaaa ggctatggac tatcgattgt agtggatgtg 1178281 ttttccggat tgctggcggg cgcggctttt ggccctcata ttgccaaaat gtacaacggc 1178341 cttgatcaaa aaagaaagct ggggcattac gtttgcgcga tcaatccatc cttttttact 1178401 gactgggata cgtttttaga gcagatggat gccatgattg atgaactgca gcaatcaccg 1178461 ccggctgttg gattcgaaag agtgtatgtg cccggcgaga tcgagcagct gcatgaagaa 1178521 agaaataaga aaaacggaat ttctatcgcc cggagcgtgt atgaattctt aaaaagcagg 1178581 tgagtaaaat gaaagcggtt caagtgcgaa aagcgtatga tctggtgaca gcggaggtga 1178641 agaagccagt tctttcaaag gatgatgaag tgctcgtgaa agtcaagcga gtcggcattt 1178701 gcggttcaga catgcacatt tatcatggaa cgaatccgct cgctaccctc ccgagagtca 1178761 tcggacacga ggtaacggga caagtggagg cagttggtgc gaatgtacag agcctaaaac 1178821 ccggtgatca tgtggtgatt gagccgattt cttattgcgg atcgtgctat gcctgccgca 1178881 aagggcggcc gaatgtttgc gccaagcttt ctgtatttgg cgtacatgag gacggaggca 1178941 tgcgggaata tattgtgctt ccggaaagac agcttcacgc ggtctcaaag gacttgcctt 1179001 gggaggaagc agtcatggcc gagccttata cgataggcgc ccaggcagtg tggagaggcc 1179061 aggtggaaaa aggtgatacc gtcctgatcc agggagcggg gcccatcggg atctgtgtgt 1179121 taaaaatggc aaaactggcg ggcgctgctg tcatgatgac tgacttgaac aacgagcggc 1179181 tggcatttgc gaaagaaaac ggcgccgatg ctgttgtaaa tgtccaagca gaacatgttg 1179241 ccgagcgggt ccttgaatgg actgggaatg aaggagcaaa cgtggtcatt gatgctgttt 1179301 gcctgccgga gacttttgca ctttcaattg aggctgtgtc accggcggga catgtggttg 1179361 tgcttggatt tgatgaaaga gcggctcaga tttctcagct gccaattaca aaaaaagaag 1179421 tcacgataac cggatcccga ttgcagacca atcagtttcc aaaagtggta gagcttttga 1179481 atggaggccg gttaatgcat aacgggctgg tgacccatac attttcagtt gatgacgttc 1179541 atcatgcatt tcagtttatt aaggagcatc cagatcaggt gcggaaagcc gtcatcacgt 1179601 ttgattaaat gactgaatcc ggaggtgcga gcatgaatat gacattccga tggtatggac 1179661 gaggcaacga tacagtcaca cttgaatacg tgaagcaaat tcccggtgtc aaaggcatcg 1179721 tttgggctct ccatcaaaag cccgtcggcg acgtgtggga aaaagaagaa atcagagccg 1179781 aaactgaata tattcaatcc tatggttttc atgctgaagt tgtagaaagc gtgaatgttc 1179841 acgaagcgat taaacttggg aacgaagaac gcggccggta tattgaaaac tacaagcaaa 1179901 cgatccgcaa ccttgccgga tttggcgtga aagtgatctg ctataatttt atgccggttt 1179961 ttgattggac acgcacggac atgttccggc cgctagaaga tggatcgacc gctctgtttt 1180021 ttgaaaaggc caaggtggaa agccttgatc ctcaagagct gattcggacg gtggaggaag 1180081 catccgacat gacactgccg gggtgggagc ccgaaaaatt ggctcggatc aaagagcttt 1180141 ttgctgccta cagaacggtc gatgaagaaa agctatggga caatttatca ttctttttgc 1180201 aggaaattct tcctgttgct gaggcctatg gtgttcaaat ggccattcat ccggatgacc 1180261 cgccgtggcc gattttcgga ctgccgcgca ttatcacagg agaggcaagc tataagaaac 1180321 tgcgggcgat atcagattca ccgtctaatt gtatcaccct ttgtacaggt tcaatgggag 1180381 ccaatcccgc taacgacatg gtggagatcg ctaaaacgta tgccggcatc gctccatttt 1180441 cacatattcg caatgtgaaa atttatgaga atggcgattt tattgaaaca tctcatttaa 1180501 caaaggatgg ttcgatcaac attcaaggcg tgatggaaga actgcataag caggattacg 1180561 aaggatatgt cagaccggat catgggcgcc atctttgggg cgagcaatgc cgcccgggat 1180621 atggcttata cgatcgggca cttggcatca tgtatttgaa cgggctgtgg gacgcttatg 1180681 aagcaatggc aaaaaaagag gtgggcatat gatcccgctg catgagaacc tggctggtaa 1180741 aacggctgtc atcactggcg gcagcggcgt gctttgctct gcgatggccc gggagctagc 1180801 ccgtcatggc atgaaggtgg cgattttgaa tcggacggct gaaaaaggcc aagcggtcgt 1180861 gaaggagata acggcggctg gcggcacagc gtgcgctgtt gctgcggatg tgctggacag 1180921 gatgtcactg gagcgggcaa aggaagacat ccttggccaa tttggcgctg ttgatctgtt 1180981 aattaacggg gctggcggca atcatcctga cgcgataacc gatgtggaga catatgaaga 1181041 agcgggagaa ggccaatcct tttttgatat ggatgagagg ggctttctaa ctgtattctc 1181101 caccaacttc accggtgcgt ttctggcctc gcaagtgttt ggtaaagaac tgctgaaggc 1181161 ggattcaccc gcgatcatca acctttcttc catgagtgct tattcaccta tgacgaaggt 1181221 tccggcatac agtgctgcga aagcatccat caataatttt acgatgtgga tggctgttca 1181281 ttttgccgaa accgggctgc gggtcaatgc gattgcccca ggcttctttc tgacaaaaca 1181341 aaatcatgat ctgctgatca accaagacgg aacgttcacc agccgatctc acaaaattat 1181401 tgcgggaaca ccgatgaagc gcttcggaaa accggaggat ttgctcggta cgctcctttg 1181461 gctggcggat gaatcctatt ccggttttgt cactgggatc accgttcctg tcgatggagg 1181521 atttatggct tattcaggtg tgtaacgaaa gcggtgcaac agaaactgaa ccaacatagg 1181581 ggtgaggttg agatgttttc aaaagataag cttcccgtta tccttttttt gttcctggca 1181641 ggggtgatta attacctgga tcgctcggcg ctttccattg cagctccttt tattcaggat 1181701 gatctcacat tgtctgccac acaaatgggc ttgattttca gcagtttttc gataggttat 1181761 gccattttta attttcttgg gggcgtggca tccgaccgct atggggcaaa gctgaccttg 1181821 tttgtcgcga tggttgtttg gtcgctgttt agcggagcag tcgccctcgc ttttggcttt 1181881 gtcagcctgc tgattatacg cattctcttc ggaatgggag aaggcccgct ttcggcgacc 1181941 atcaacaaga tggtgaacaa ctggttcccg ccgacccagc gggcgtccgt tatcggtgta 1182001 accaacagcg gcacgcccct cgggggagcc atttccggcc cgatagtcgg catgatcgca 1182061 gtggcgttca gctggaaggt atccttcgtt ctcattatga ttattggatt gatatgggca 1182121 gtgctctggt tcaagtttgt caaagaaaag ccgcaagaga cgatcaagga agcaccggca 1182181 ataaaagcag aaacgtctcc cggagaaaaa attccgctca ccttttacct gaagcaaaaa 1182241 acagtcctgt tcacggcgtt cgcttttttc gcttacaact acatcctctt cttctttttg 1182301 acatggtttc cgagctatct tgtcgacgag cggggattaa gtgttgaatc gatgagtgtc 1182361 atcacggtca taccgtggat tttaggattt atcgggctgg ctgcgggggg atttgtttct 1182421 gactatgtgt acaaaaaaac ggcccgaaaa ggtgtgctgt tctcgcgcaa ggttgtgctt 1182481 gtcacgtgtt tgttttcatc agctgtcctg attggttttg ccgggcttgt ggcaacgact 1182541 gcgggggctg tcactcttgt cgctctgtca gtgttctttc tttatttgac cggtgctatc 1182601 tattgggctg tcattcaaga tgtggttgat caaaacaatg tcggttctgt tggcggcttc 1182661 atgcatttcc tcgccaacac ggcaggaatt atcggcccgg ctttaaccgg atttattgtt 1182721 gaccaaacag gcacgttttc tggagcattt ttgcttgccg gtgggctggc tgtcttcgct 1182781 tcacttgctg tgattcgttt tgtccgtcca atcattggta agccagcggg aacagaagct 1182841 gagaatcctg tgtcttatta atctggaaat atagtgggag aggcggtatg tttgatgata 1182901 caatatacag taaataatcg cagccggtat gataaggaag ggaattagat ggtaaccata 1182961 aaagatatcg caaaactcgc aaacgtatcc cacactactg tttccagagc actcaacaac 1183021 agcccttaca tcaaagaaca tacgaagaaa aaaatattag agctagcaga gcagctcaac 1183081 tatacaccaa atgtaaatgc gaaaagtctg gcgatgcaaa agtcgcatac gatcgggcta 1183141 ttctttacaa gcattacaaa cggaacctca cacagcttct ttgcagacac tatcaaaggc 1183201 gtcaatcaag ccataagtga ggattacaat ctgtatgtgc gcggcattga tgatctgaaa 1183261 aactatgact ccgttacacc gatgagatat gacggcatca ttttaatgag ccaaagtgac 1183321 attgataatt cttttattta ccatattcgc gaaaaaaaca ttccgcttgt cgtgctgaat 1183381 cgtgatattg atgatcgtac catcacgaat attttgtcca atgacaagga aggctctcaa 1183441 gaagctgtag aatacttcat tcagtccgga catcaagaca tcgccatcat cgaggggatc 1183501 gaaggcttta aatcctccca gcagcgaaag gaagggtact tatccgcact gattcaacat 1183561 catattccga tcaagcatga atacagtgtc aaaggacagt acgatatgga aagcggcttt 1183621 caagcgatgg agcggctgct ggcactgccg aatcctccaa ccgctgtttt ttgttcgaat 1183681 gatgacatgg caatcggagc gatgaatgcg atattcgcaa agggcctgcg cgttcctgat 1183741 gatatttcgg tgatcgggtt tgatgatatt gggttttcac agtacatcac gccaaggctt 1183801 tcaacagtaa agcgcccagt ggagaaaata agcgtgctcg gtgcgcaaaa actcttgtcg 1183861 ctgatcagcg agcccgaaac aaaagcagaa aaaatcttgg aaaacacaga atttatggtg 1183921 cgtgattcag tcagacgatt gacgacgtga tgtcccgttt ttcagcgggc attctttata 1183981 cagaaaaatg ttaacgtgtg cataaagtga gagggaggca ataagggtgc agaagctgaa 1184041 taaaaatgtg tacgatcact atactcagta tccagaaaaa attctccaat tcggagaagg 1184101 aaactttctt cggggattta tcgattggca gattgatcaa ttgaatcaac acactgattt 1184161 taatgggagc gtggcagttg tccagccaag aggctcagaa aaaatcaaac gattaaatga 1184221 gcaagatgga ttatatacac tttttttaca aggaatgaaa gacggagaag cggtaaacga 1184281 gcatatgatt atcaactcaa tcagccgggg aattgacctg ttttctgatt atgaagcata 1184341 caaagaattg gcatcaagcg aaaggcttcg gtttattatc tccaacacca ctgaggctgg 1184401 gattgtatgt gatgaaaaag atcgtttaga ggataggccg caaaaaacat tccctgggaa 1184461 attaactgca tttctttact ttcgctatca ggcttttaaa ggagatcaga caaaagggtg 1184521 tgtcctgatc ccatgtgaac tgatcgagaa taacggtgaa aagctgaggg aaacggttct 1184581 tcattatgca catctgtgga agctggagga aggatttaca cagtggattc atgaggccaa 1184641 tacattttgt aatagtttag tagaccggat tgttccgggt tttcccgtcg acagcattga 1184701 tgagatcacg gcagatcttg gctatcagga tgatttgata gttgtgggag agcaatatta 1184761 tttgtgggtt atcgaggggc ctgattggat tggaaaagaa cttccctttg cggctgcagg 1184821 gctgcataca aagatcgtca gcgacctcac cccataccgg actaaaaaag taagaatttt 1184881 aaatggcgct catacagcaa tgacgccagt ggctttatta tacggcttga agactgttag 1184941 ggatgcagtc gagcatccgg aagtggggcg atttataaga gagctgattg atgacgaaat 1185001 tcttcctgtt ttaaaaatgg aaggtctttc tcagtatgct gacgatgtgc tgaaccgttt 1185061 taaaaacccg tatattaagc attacctgga aagcattgca ttgaacgcca tttccaaatt 1185121 caaaacgaga aacctgccga ctcttaagga atatgctgaa caaaagggac agcttcctga 1185181 acgcttggtg ttttctttca gcgctcttct gtatttttat catgataacg agacattgca 1185241 ggatgatccg gcagttcttc aatttttcaa agaggtttgg tgtcaggagg atggcgacat 1185301 gcttcggatt gcatcaagag tgttaggcga acagcggctg tggggggcag atctcaatga 1185361 gataccgaag ctgactgata gagtcgctgt ttacttgaat catattcatg agctgggcat 1185421 gcagagggct cttgaacaat actgcataca agggggagag gtacgttgaa gtcgtttata 1185481 aagattcata agcaagataa tgtccttctt gctctgcggg atattcaaaa gggagagagg 1185541 ctgcatgctt acggcgtgtc gattgaagta aaggatgata taaaaagagg ccataagatt 1185601 gcattgcagt ctatcaaaga aaacgacagc atcgtcaagt acgggtttcc aatcggtcat 1185661 gcatcacaag atatctcgat cggagagcat attcatgtcc ataatacgaa aacaaacctg 1185721 tctgatatcc aattatacag ctatacaccg agatttgatg aaaatccgta ttctaatgag 1185781 aaccggacgt ttaaaggttt tagaagagaa aacggagatg cgggtgtacg gaatgaattg 1185841 tggattgtcc caactgtcgg ctgtgtcaat ggaatagcag aaaaaatgct gcagcgtttt 1185901 gtcagagaaa caggggatat cgctccattt gataacgtac tggtgttaaa gcatcaatac 1185961 ggatgctcgc agcttggcga cgatcatgaa aatacgaagc agatcctgct gaatgccatt 1186021 cgccatccaa atgccggcgg cgtcttggtg ttagggcttg gctgtgaaaa caatgagctg 1186081 gcaagaatga aggaagcact gcaagatgtg aacttgaagc gggtgaagtt tctggaatcc 1186141 cagtcggtga ccgacgaaat ggaggcaggc gttgctttgc tgaaggaaat tcatgaagcg 1186201 gccaaaggag ataagagaga agacattccg ctgtctgaac tgaagatcgg gctgaaatgc 1186261 ggaggttcgg acggtttttc cggcataacc gcaaacccgc tgcttggacg tttttcagat 1186321 tatctcattg cacagggagg gagtactgtg ctgacggaag taccggaaat gttcggcgca 1186381 gaaaccatcc tgatgcagcg ggctgccaat gaagaagtgt ttcataagat agtcgattta 1186441 atcaatgatt tcaaacaata ctttattaaa catgatcagc cggtgtacga aaatccttca 1186501 ccgggcaaca aagcgggcgg catttctaca cttgaggata aatcgctggg ctgtacgcaa 1186561 aaagcgggga tttctcctgt cacggatgtc ttgaaatacg gtgaagtact caagacaaaa 1186621 gggctgactc ttttgagcgc accgggcaat gatttgatcg cctcctccgc attggcggct 1186681 gccggctgcc aaattgtcct ctttacaacg ggaagaggca cgccgtttgg cacctttgtc 1186741 ccgacggtga aagtagcgac aaacaccgag ctgtatgagg cgaagccgca ttggattgat 1186801 tttaacgcag gccttttagc agaggatgat gttcatgagg aatatgtgct gcgtgagttt 1186861 atccactata tgattgaggt ggcaagcggc cagcttgtga accatgaaaa aaatgatttc 1186921 aaagaactcg ccatttttaa atcgggtgtg acgttataat aagaaaaggc tatccttcaa 1186981 gcggatagcc ttcttcatta aatcaatttt aaaccgctga ctaaaataat ggaagccata 1187041 ataaattgca gtggacgcgg ggagaatcga ggcgaaagat ggctcccgat cagtacgccg 1187101 ggaattgaac cgaggagcag attagctgcc agcatgtaat ccacgcttcc gaagcttgcg 1187161 ttcaaaatgc ctgctgccgt aacaagaaga aaagcatgcg cgatatcggt tccgacaatc 1187221 tgtgacgctt tcatgttaaa taagtaaatc atggcgattg caaataatga gccggacccg 1187281 attgatgtta atccgacgat aaacccaaac acaacaccaa taagaattgt cagcgccctc 1187341 ttattttcaa gcggcatcag ctgccagcgg ttggggcgaa gttttctatc caaaaacaaa 1187401 cgaacgatga ttgaaatggc aaccagcgtt aacacatatc ctagagcgtg cttaataatt 1187461 tcttcctgat gctggtgaaa ggcggggaac aaatgcaata tgccaatggc tagcgaagca 1187521 ctcggaatac cgccgatggc taagtatttt accaatttaa agttaatcgt tttctgccgc 1187581 caatgggagg caacgccaaa cagctttgtg atcgagttat atacaagatc cgtaccgacc 1187641 gcgatggaag gattaattcc aagcacaatt aaaaggggag ttaataaggc cgctccaccc 1187701 actcccgtca atccgactaa ggctccgaca aacaaaccca tcaatatgat gcttacactc 1187761 atgataaagg cctcctgaaa acccgactag aattcacccg aatcttattc gcgttggtca 1187821 agtattaatt gtaagtgctc catcggctgc tgaaaaaccc gagctctatc cgctccctga 1187881 tggtatcatt caattgacaa caccttatac atcaggagaa cacgtctttc aggtgcaacg 1187941 agcacttgcg gctctgtatt tttaccctga taaaggcgct gttaacaacg gaattgacgg 1188001 cgtttacgga ccgaaaacag ctgacgcagt tgcccgtttt cagtctgtta acggtctaac 1188061 tgctgacggt atctacgggc ctgcgacgaa agagaagatc gcagcgcaat taagctgatc 1188121 aaagaccata aaaatcccgg agccgctccg ggatttattt tttcttcttc aactttttta 1188181 taattccagc actgcgctcc ctcacccgaa gcgagtaccc ggaaagccca aaccttccgt 1188241 aatcaacaaa cttcacacgc ctcaccaatt ttttcactgt atcacctgac attatcctct 1188301 gtttgtattt attatatgtc accctttaag aaaaggaata aggacaagag ctgttttccc 1188361 ttgtcctttt agtgtgatca tgcttttttt cgtttatact cgtcaatcag ccgttcgttt 1188421 tctttgaaga ttcttgctgt atgcggactg acttgatagc ttgcgacact ggtggttgaa 1188481 cgttttttca ggattttaaa cggcttcgcc gctctgggct cgcatctgtt ttgaaacgca 1188541 cgttccatta tccttcacct tcctcctcaa ttggcagcac caaatcatat atgctcgtta 1188601 atgacgtaaa tagcaaataa tcaaattccg tgacaatgct gtcagacgtc agcttgatga 1188661 catagttctg tgtctcgatg gtaaaaggga tgagaaccac ttttccgtat tggtcgtaat 1188721 aaacatcctt tcgatcgagc cgtgtttgta catctgccgg atcatccata tgctcggtta 1188781 accggtcttt atcagcctgt gtcgaatagt ggcaaagaga agccgttaag ttcattttat 1188841 cagcataggt tttcagcagc ttatcaatac cttcagcata agcatctata cttccataat 1188901 aaacatggat cggttcgttt ttcaataggt attggtatgt tttcagccga ttgagataca 1188961 tgtggagcat ttcgttgttt tcttcaagaa tttctcttgt gtctgtttca agctcgctgc 1189021 cggccagttt tttgacatat gcacttaaga agataaaagc atcaatcaaa gcaaaactga 1189081 ctgcgacaat gagataccgt tcccagtggg taaataggga agtgggctca tatgtccagt 1189141 ataccatagc gcccagaaca aacagcaaat accaagtttt ccgaatggcg gacatttttt 1189201 ctttgacctt cgcttcgaaa cgccacgtgg catacacgta taaccccagt ccggccacga 1189261 tgcaccagac catgatctga aagaataaaa ccatattcga atccctcaca tctgaaatag 1189321 gttctgctta ttgtattcga gagatccgga tggttttcct gttccatcaa aaaaaccgct 1189381 cctttgacag aagcggtgtg acattaaaat atcatattta aaataaagta ggcgatggca 1189441 ccaagtgtcg ctgaaatcgg aagcgtgatg acccatgtaa tgagcattcg cttggccgta 1189501 ccccagttta cgccttttac gcggtgggac gcaccgacgc caagaattga tgaagaaatg 1189561 acgtgggttg tactgaccgg caaatgaata aacgtggcgc cgaaaataat ggctgctccg 1189621 gttaagtcag cggaaacacc gtttaccgga cggattttca tgatctttcc gccaacggtt 1189681 ttgatgattt tccagccgcc gattgatgtt ccgagaccca tggctgtcgc gcaggcgaat 1189741 tgcacccagg taggaatatc attagcagaa gtatgtaaat tcgctgtgat gagagccatt 1189801 gtgataattc ccattgcttt ttgcgcatcg tttgttccgt gtgtatacga ttgcagggca 1189861 gctgttacaa tctgcactct gcggaattgc ttattcgttt tcgccaagtt gctgtctttg 1189921 aaaatcagct taacgatgct ataaagaata aaaccaagga caaaggcaat aattggtgat 1189981 agaatcagtg cttcaatgat tttaatgaag cccttatagt ttaacgctgc aaatccggct 1190041 gccgcaatgg ctgcaccggc aatagcgccg atgatggcat gggatgagct gcttgggata 1190101 ccgtagtacc atgtgataag gttccaggca attgcagcga gtagcgcagc caaaatgaca 1190161 acagagccat tttccagcgt ataaggatct acgatgtctt tcgtaatggt tttggcaaca 1190221 cctgtaaacg tcattgctcc gacaaagttc atcacagcag ccaatataat ggcatggcgc 1190281 ggttttaacg cttttgttga taccgaagtc gcaattgcgt ttgccgtatc atgaaacccg 1190341 ttgatgaaat caaacgccag agcacaaatg actattagta tcgttaatat taatagaata 1190401 tccattttta cccctcgtta cgcgtttttc ataatgatgg tttcaagatt attggcaaca 1190461 ctttgacaag agtcggcgat ttcttcaagc gtttcgtata tttcacgata ttgaatgact 1190521 ttgattggat ctgtttcatt tccgaaaaga ttctttaatg attttctgtg caagttgtca 1190581 caactgtgct catactcttt aattttgatt gcgtgaggct gaatatcctt taagcgattt 1190641 tctgccagca gctcgatcgt aatcaaaatc tctttcgcac attctctgat atatccgctg 1190701 aatttatcaa tatgctcgtc tgatgaagta attgagaaaa tctccatcat ggcagagaaa 1190761 tgttcgattc cgtcaagcac atcatccaag ctgtttgtca gctgaaggat atcttcgcgc 1190821 tcaataggag tgatgaacgc tttgttaagc tctttaatca tgacatgaac atgattgtca 1190881 ccttttgttt catattcctt taacgtatct gcaaattctt taagagtcgt ttggttagtg 1190941 accttaaaat tcacaaaata ttctgcagtt tcgtctatgt tctttgcaat ttctgttaaa 1191001 aggagtgaga acttatcttt ttttcttctt atcattaaaa accctccata gtttgaatga 1191061 acaatgcaca catcaaatta ttatatagcc ttttgtcgaa aaaaaacagg taaagtcgaa 1191121 aaaaacgtat cttgactttt ttgataaatc gtgtctcctt attttgacct acttcgcttt 1191181 aaaaaaacga cccaagtttg caaaaacttt ctgcttaacg taaaaagtat atcaaaagtt 1191241 gtgtttttcc tgtcaacttt tatcttctgt ttcaccaaaa aacggttccc taaacaaggg 1191301 aaccgtttta tcagcttgct tttcgttttt tcatcccgta ataaacaggc agtccggcaa 1191361 ggccgatgag gatggataat ccgcagctca ttgtatctgt aatgagtgtg ctgcctaaca 1191421 caaagaagga gcccgcgatt gccagaattg gcataaatgg ataaagcgga acactgtagg 1191481 cgcgcttttc tccctttgct cgcttgcgga gaataaacac tgcaaaaaag gccatcacat 1191541 aaaaaatgta gatcatgaaa atggagattt ctgagagctt atcagggttg ctgatcagca 1191601 tcataatcaa agccaaagca atttgaaaag aaatcgcaat ccatggtgtg cggaacgacg 1191661 ggtgtacatg tgacagtttt tcagcaaatg gaagctgttt gcgttccgcc attgcaaatg 1191721 aaacacgcgg gaaagaaagc acctttccat ttaagcaccc aaagatgctg acgataatcc 1191781 ctacactgat cagctttccg ccaattgaac cgaacagcat ggttgcagcg gtgcttgtcg 1191841 cattttcacc aagcgtgaca atttcgttcg ctgacaggat gtgaagcaat gcaaaattaa 1191901 tgaaaatata gatcgccgtt acaattaata atccgcccgt catagcgcgt ggcagcagct 1191961 tttcgggatt tttcatttct ccgccgagag cggcaaggag aatccatccg tcataagcaa 1192021 acaacgtagc taaaatagcc gccccgaagt tcatatcaga aatgctttcg tttactgctg 1192081 tgaagatgtg ctgatcgcct ttccaaaggc caaagacgat gatgcaggca atcggaatca 1192141 gttttccgat cgttgtcagc gtttggacaa aaccgccgta ttttgtaccg ataatattaa 1192201 tgacgcataa aaagagaact gctataattc caatgacttt tgatagtcca gatccccagc 1192261 cgaaaagatt cgccattaaa gatccaaaat ataaacccag cgcgccaata atcgccgggc 1192321 cgtaaatgat aatctgcacc cagccgcaca aaaatcccca aaactcgccg tacacttctt 1192381 caaggtacgt ataaagcccg ccggtttttg gaatctgcgt tccgatttcc gcgattgtca 1192441 aaccgcccgc cagtgttaaa ataccgccta acagccaggc gaaaagcgcc atttttgaat 1192501 cacctgaata agcaagcaca gcgccgggct tcataaaaac accagaaccg ataatggttc 1192561 cgatgacaag agtaagggca aacaagaggc ctatctcttt tttcaaaccg ttgtcttcag 1192621 tatgcatgtc cttaacctcc tatgatgttg aagcttcatg ttgaagaatc tattttttca 1192681 tattgtaaac cctattttag aaaagtgaaa taaaataaat tttctgattt tcgaaatttg 1192741 ctttgtgtac agcagataaa actgtagaaa tacctgtttt aatggtctat aaacgaataa 1192801 aattcataat ttttatttac aaagttcgtg ttttatgtat taggatttta gccggtacag 1192861 aggggagatg agaattcaga aaatgaacga accttcggtg aagctgatat gttgactttc 1192921 tcatgcgaat aaaatacttt gttattagaa caataaatat acaattatga tatgatatct 1192981 cgaaatcgag ataaaataac ctggagggac agcatatgaa agttaacggc attcaccacg 1193041 tatcggcatt aacggccgac gcacaaaaaa acttggattt ctataagaaa gtattaggat 1193101 taaagctcgt caaaaaatcc gtcaatcagg atgaaccgac aatgtaccat ctgttctacg 1193161 gagatgaagt ggcaaacccg ggaactgagc tgacgttttt cgagattccc cgcattgcac 1193221 cgtttcatgc gggaacaaac agtatttctt ctattggatt gcgcgttcca ggcacagaag 1193281 ccctgcatta ctggaaagaa cgttttgaag agcagcaagt aacgcacagc ggcatctcca 1193341 aaagagccgg acgtgacata ttggcatttc aagatcatga ggggcagcga cttgtgctga 1193401 ctgctgatga ggaaggaaaa ggatatggcc tgcctgttaa acagagcggc attccggaag 1193461 aattttcgtt tcgcgggtta gggccggttg aactgactgt gccatatgct gaaccaactt 1193521 tacacgtatt gacgaatatt cttggattta cagaaatcag ccgtgaacca gtcgaagggc 1193581 aaggaaccgc cgttattctg gaatcaggag aaggcggtgc tgcaacggaa atccatttaa 1193641 tagaaagaaa cgatcttccg cgagagcgtc aaggcaaagg gagtgttcac cacgtcgcat 1193701 ttcgggtaag agatgaagaa gaacttgccg ggtggcaccg gatcatcagc cgcgaaggct 1193761 ttagcaattc aggcatagtt gagcgctact atttcaaggc gctgtatttc agagaaccga 1193821 acggcatttt gttcgagtta tcaacagacg gaccgggctt tatggtagat gaaaatcttg 1193881 atgagcttgg ccaaacgatt gctcttccgc catatctaga gcatcgaaga gcagaaattg 1193941 aagcaaaatt gaaaccgatc caataaattg tgattctttt gccttccggc gccgccggag 1194001 ggcttttttt attaccataa ttaattttga cctaaacagc atgccttatt agggaggaaa 1194061 tatcagatgc tgattgggag aaatggctta aaaccctttg caaatatggg tgattggtat 1194121 ggaatggcct cggcaaaaat attgtctttg tttattaata gtttattcat atttgcttgt 1194181 tacactattt caaagttaga caaaaaggag tgaaaaataa gtggaaaaga aaaaacgcga 1194241 gctggatatc gtcctcctcc tcattttgct cgcatctgca ttcttaaata tctataacat 1194301 ttggaaggac gacacggtga atccttatta caccgcggca gttacaagta tgatgcaaag 1194361 ctttcataat ttcttttatg cttcgttcga tgctgccggc tttataacag tagataaacc 1194421 gcctgttaca taccaaatcc aaacgatcag cgcactgata ttcggtatgc acggctggag 1194481 cgtcatcctg cctcaggcac ttgctggtgt aggttctgtc cttcttatgt acttgctgat 1194541 aaagccgaca tttggaaaaa cggcggcgcg tattgcctca tttgttatgg catgtacgcc 1194601 gatagctgta gctgtagcac gtacaaacaa tgttgatgca ttactggtat ttttcttatt 1194661 gcttgctaca tggcttctct ttaaagcgat cagaaaagga aagctgatct ggctgttagc 1194721 agcatttttc gttgttggag taggttttaa tacaaaaatg ctgcaggctt acatgatttt 1194781 accggctttc ttattgttct atctgattgc ggcaaacgcc acaatcaaga aaaaaatcgt 1194841 ttcattggta agtgcgttag ccgtattagc agccgtttcg ttatcgtggc cgctcattgt 1194901 tgacaatatc cctgcaagca agcggcctta tatcggaagc agccaaacca actctgtttt 1194961 ggaattggct ttcggctata acggaatcca gcggctgaca ggccaaaatt caggcggcgg 1195021 ccagggtgcg ccaaacaaag acgcttcaaa agaaatgtct tcttctgata acactcaagc 1195081 accgcctaat cagtcatcaa gcaacagctc atcaagcgat ggtaaatcct caaatggcaa 1195141 tatggcggcg cctccatcca atggccaaat gccaagcggc ggtcaaggag gccctccaag 1195201 cggcggagat ggcggccaag gcggacccgg cggagacgga gggaaaggcg gtacaggaac 1195261 cggttcgaaa atgcaatcag gttcagggat gtttggaacg ggaacacctg gtccactgcg 1195321 gcttttccaa caagagttat ctgatcaaat cagctggctt ctgccatttg cgatatttgg 1195381 aatcgcaggc ttactgatcg ctggcgcaag agaaagaaga agattatctg tagagcagaa 1195441 ggaaacggtg ttctgggttg cgtggcttgt accgattgcc ggattcttca gtgtcgcaga 1195501 atttttccat cattattatc tcatcatgct ggcaccgccg attgcggctc ttgtcggtgc 1195561 ggggtgggtc gctcttgttc atctgtaccg caatcagaca ggctggaaag catggctttt 1195621 gccgggagca attattgcga caactggatt tgaattgttt attctcagaa actacaacga 1195681 tcaaatcggt gttggatgga gtatcggggt aggtgttatc ggcgtgttgt cagcgattgc 1195741 tttgctgctg tttaaacagc gccaaaaacc gttcagttat tatgtttcac ttgcagctct 1195801 cctcgcattg ctggtgatgc cgatgtattg ggcaagtaca ccgcttctgt acggaggcaa 1195861 cagctcactg cctgaaacag gccctcaact cgcatcaatg agcggaaaag gcatgggaat 1195921 gtctgatgcg actgtaaatg aaaaactgat caaatatcta gaggagaata actccggagc 1195981 tgaataccta ttcgccacaa ccgattcgaa cacagcggca ccatatatca ttaaaacgaa 1196041 aaaagctgtc atggctattg gtggatacag cggttctgac ccggcaatca cactgactca 1196101 attcaaaaaa cttgtaaaag aaggaaaagt gaaatacttc ttggcttctg gaatgggaag 1196161 aggcggaaac aatgacattg ttgaatgggt tgagaaaaat ggaaaagaag tagcatcaga 1196221 aaaatggcaa tcaagttctg atcaaaaaac agaaaatact gattcagctg atacatcaag 1196281 cagcaaggct tcaggtgaaa acggcaaaat gggcggacct ggcggaatga atcagtcagc 1196341 aacattatac gaactacatg ctgatgaata ggaggcaaaa acatgagcag acatattcaa 1196401 tattcaattg ttgtacctgt gtataatgaa gagcttgtca ttcatgaaac ctatcagcgc 1196461 ttaaaagagg tcatggatca aacgaaggaa aactacgagc tgctttttgt caacgatggc 1196521 agcaaagacc gcagtattga gattttaaga gagcacagcc tgatcgatcc gagagtgaaa 1196581 attattgatt tttcaaggaa ttttggacat cagatcgcca ttacggcagg tatggattat 1196641 gcacagggga atgcaatcgt cgtcattgac gccgatttgc aggaccctcc tgaactgatt 1196701 ttagaaatga ttgaaaagtg gaaggaaggc tatgaagtcg tgtacgccgt acggactaaa 1196761 cgaaaagggg aaaccttttt caaaaaacaa accgcggcta tgttttaccg gcttctcagc 1196821 ggtatgacag atattgatat cccgattgat acgggggatt ttcgcctcat ggacagaaaa 1196881 gtctgtgatg aaatgaagag attaaaagaa aaaaatccat ttgtaagagg gctagtcagc 1196941 tgggtgggtt tcaaacagac agcggtcgag tatgtacgtg atgaaaggct cgccggagaa 1197001 acaaagtacc cgctcaagaa aatgctgaag ctgtcaatgg acggcatcac gacattttca 1197061 cataaaccgc tgaagctggc aagctatgcg gggattttaa tgtcaggtac tggatttctg 1197121 tatatgttta tcgtgctgta tctgaagcta ttcacagaca gcacgattac cggctggtca 1197181 tcacttattg tgatccagct cctgttcagc ggcattgtcc ttctgatttt gggcgtgatt 1197241 ggcgaatata tcggcagaat ctacgatgaa gccaaagaca ggccgcttta catcgtccaa 1197301 aaatcgtatg gaattgaaaa taaaagactc tatagagacc agcatatgtc ataacctcaa 1197361 accccctgtc cgtaatggac agggggtttt tatgctctga gcacgatcta aagcaaaaga 1197421 tgctgataga tatatggaaa ttgggtaaag aagagattgt gagcttgtac tgcggttcag 1197481 tcatgctgaa ataaaaacag caaaacttaa agatttcgtc ctcggctttg ctgcatgtca 1197541 gctgttatat tggggggctt ttaagaaacg catgattaga gccgtaccag ttatgtttaa 1197601 tagaatactc gtacccaata caattcccca cgtcaacgtc gattcagaga gaagaaagct 1197661 cagcaaaaga aaagccaatc ctgcgcagat catacccagt cccacggttt tcatgttcat 1197721 gcctcctagc aaacgatgtt tctagcatct gatgtgaatg atgtcaatct gtatgatata 1197781 cggatatctc gtcagaaagt ttcatagaac aattaggtct tttatctaat aaaaagcctc 1197841 agaccgcttt tacggcctga ggcattatgt cttacgaagt tttctcttct ttttgatcca 1197901 gtttaatttt tttcgtcatt tctttgccgt ttcggagaat tttcacttca acggtatcac 1197961 cgatctttgc gtctttatat aagatattgc gcaattcact gcctgtatca atttctttac 1198021 cttttaggcc gatgataata tcctccgctt ttaatccggc cttttcagca ggagagcctg 1198081 aagcgacctc acggatgtaa acgcctttat tcagctggct gccgaacagg ccgagtgtgc 1198141 cttcttggta attttgcggc acttgctcta gatcaagcat gctgacaccg atatatggac 1198201 gttcaatttg tcctttagac agcaattctt cagcaatcgg ttttacgtca ttgcttggaa 1198261 tggcgaatcc gataccctca acatcatcct cactgatttt catactgtta atgccgacaa 1198321 ttttgccgtc tgtatttaac aaaggaccgc cgctgttacc tggattaatt gctgcgtctg 1198381 tctgaatgac gttaatgctc gtttcgccgg ctgatgtaga cattgaaacc gttctgtcca 1198441 cgccgcttac aattccttgt gttactgtgc gggacaggtc ttttccaagc ggatccccaa 1198501 tcgcaataac ggtctcgcct gttctaagat cagatgaatc accgaagttt gccacttttg 1198561 tgacgtggtc atcactgatt tggaggacgg ctaaatcagt taacgagtca ctgcctacca 1198621 gctttgcagt aacctcagtg ccgtcatata aagatacctt cagtgatgat gccccttcta 1198681 cgacgtggtt atttgtaatg atataagcct tgccattctc ttttttgaaa atgacacctg 1198741 accctgaacc gctttctgta tcttcgctgg aatcagaaga actagagccg aacaaagagc 1198801 tgtttgattg tgcctgaaga tttgtaatac cgacaatcgc tggtgaaagg tcttctacca 1198861 tatctgagat tttagaagag tcctcgctct tgaatgcaga tgagctgctt gagctttttt 1198921 tagattcaga ggaggtgctt gttgctgtaa cagattgcgt ttgctgctgg ctggatgatt 1198981 gttttgcagt gtcctgagaa tcatggtcac caagcggtgt aaacgtgtaa atgccaagag 1199041 caagactgcc gccgatcact ccgccaagca acggtctgaa ccatccgaat cctcgttttt 1199101 tcttctcctg atcatgaatg acattgcggg ccgagtagga ggcgctctga tcgttctctt 1199161 tcgttaaaaa gacctcattc tcattacctt tcgttctgtt ttcatcacga tagttatcca 1199221 tcatgttcac tccgtttctc tattttcaca tgtctattta tattgatagg tttatgactt 1199281 gagtttatca taaacaaaaa ctgtgggata aaaatgaaaa gattatggga aattgtgaaa 1199341 aagtgcggaa aacggtacac ttcatattgt atatgaaagg actgagtcga tggaacagat 1199401 tggattgatt ggatatggca gcatggcgga tatgatcgct agacagctgt tgaaacatga 1199461 acaaataaaa gagaatgagc tatttattga gacgagaacg aagggggagc ggctgcgggc 1199521 actcatgtca gattatccaa acgtatcggc tgatccgttg gagaattggg caaatacgtg 1199581 ccaattgatt ttgatatgcg tcccgccact ccatgtcatc gaaacaatgc gccgtctgta 1199641 cccgtatgtg aacagaaata ctcacatcgt atccatagct gccggtgtgc cgctgcgtct 1199701 tttggaggca gaaacagaag ccggtatctc acgtgttatt cctgccatta cgtccgaagc 1199761 agaagccggc atctcacttg tcgttcacag tgaagcactg gctgcagaga aaaaagaacg 1199821 tctgaatgaa ttgttatcgg ttttcagccg tgtacgggaa atcaaagaat cgaatttaga 1199881 tgtggccagc aatttaacga gctcggcacc gggattcata gctgcaatct ttgaagaact 1199941 ggcactgtct gccgtcagaa acagcagcct gtccaaagaa gaagcctttg attttctgat 1200001 tcattcgcta tacggaactg gcaagatgct gatcgaaaaa aatatgtctt tcgaggagac 1200061 gctggaacgt gttgcaacca aaggcggaat aacgggagag ggagctgagg tgatacacgc 1200121 ctctgtgccg gacgtttttg atgaggtatt tgaaagaacc ctgagaaaat atgaactgct 1200181 tacagaacag gttggtaaac aaacatgaat ccttgaaaga ggattctttt tttatcactg 1200241 aatgattgag atttttccca gttatattgc atttttcctc tttttttaat ataatttgtt 1200301 agaatattca taatttagta aaaaaggagg agcgttatga aattgtacat gtcagtagat 1200361 atggaaggta tttcgggtct tccggacgat acctttgtgg attccggcaa gcggaattat 1200421 gaacgcggac ggcttatcat gactgaagaa gcaaactact gtattgctga agcgtttaac 1200481 agcgggtgta ccgaggtgct ggtcaatgac agtcattcga agatgaataa tctgatggtt 1200541 gaaaagcttc accctgaagc agacttgatt tctggtgacg tcaaaccatt ttcaatggtg 1200601 gagggactgg atgatacgtt tagaggcgct ttgtttctcg gttatcatgc gagagcctcg 1200661 actcctggtg tcatgtcaca cagcatgatt ttcggcgtcc gtcattttta cataaacgat 1200721 cggcctgtcg gtgagcttgg attaaatgca tacgttgccg gttattatga tgtcccggta 1200781 ttaatggtag ccggggatga ccgggcggcg aaggaagcag aagagcttat cccgaacgtg 1200841 acgacagccg cagtcaaaca aaccatttca agatccgcag tgaagtgctt gtcgcctgcg 1200901 aaagccggac ggctgttgac agaaaaaacc gcatttgccc tgcaaaacaa ggacaaagtc 1200961 aagccgctca caccgcctga caggccagtt ctgagcattg aattcgccaa ttatggccaa 1201021 gcagaatggg cgaatctgat gccgggaacg gaaatcaaga cgggaactac aaccgttcaa 1201081 tttcaggcga aggacatgct tgaagcctat caggcgatgc ttgtcatgac tgagcttgcg 1201141 atgcggacat cattctgcta aaggggtgtt ttaggctttg gcgcgataca tgataaagcg 1201201 tttttgggca atggcagcta cgattttggt gattaccacc ctgacttttg ttctcatgaa 1201261 ggtcattccc ggatctcctt ttaacgagga gagaggcaca aatgaagccg ttcaaaaaaa 1201321 tctcgaagcc tactatcact tagacgatcc tctcattttc caatacattt tctacttaaa 1201381 atccatcatt acattcgatt tcggaccttc aattaaaaaa ccgtcggaca gcgtaaatga 1201441 tatgctggaa cgcggatttc ccgtttcctt tgagcttggg atgacagcga ttgtcattgc 1201501 tgtgatttct gggctggtgc tgggcgtaat cgctgcactc cgccgcaatg gctttttgga 1201561 ctacgccgcg atgagtcttg cagtactcgg catctccatc ccgaatttta ttctggcaac 1201621 attgctcatt cagcaatttg ctgtcaatct caaactattt cccgctgcga catggacgag 1201681 cccgattcat atggtgcttc cgaccgcagc gcttgctgta gggccaatgg cgatcattgc 1201741 caggctgaca cggtcgagca tggtcgaagt tctgacacag gattatatcc gcacagcaaa 1201801 agcaaaaggg ctttctccgt tcaaaattat cgtaaaacac gcactcagaa atgcactcat 1201861 gcccgtcatt accgtcctgg gcacactcgt cgccagcatc ttaacaggaa gctttgtcat 1201921 tgaaaaaatc tttgccattc cgggaatggg aaaatatttt gttgaaagca ttaatcagcg 1201981 ggactacccc gtgattatgg gaacgaccgt tttttacagc gtcattctga ttatcatgct 1202041 gtttttggtc gatttggcct acggtctctt agacccgcgc attaaactgc ataagaaagg 1202101 gtgaagcgtg tgaatctccc tgtacaaacg gatgaacgcc agccagaaca gcacaatcag 1202161 gtgcctgatg agtggtttgt cttgaatcag gaaaaaaatc gggaagccga ttcggtcaag 1202221 cggccgagtt tgtcatacac gcaggatgcc tggaggaggc tgaaaaaaaa taaattagcg 1202281 atggccggac tctttattct tttatttctt tttgtcatgg cagttatcgg gcccttttta 1202341 tcgccccata gtgtcgtacg ccaatcgctg acagaacaaa atcttccgcc ctcagccgat 1202401 cattggttcg gcaccgatga actcggccgg gatgtgttta cccgaacatg gtatggcgcg 1202461 agaatctcgt tgtttgtcgg cgtgatggca gcactgattg attttttgat cggtgtcatt 1202521 tacggaggcg ttgccggcta taaaggcggc aggattgaca gcattatgat gcggattatc 1202581 gaagtgctgt acggactgcc gtatctgctt gttgtcattt tgctgatggt gctcatggga 1202641 ccgggactgg gcacgattat tgtggcgctg actgtgaccg ggtgggtcgg catggcgaga 1202701 attgtaagag gccaggtgct tcagattaaa aattatgaat atgtactcgc ctcgaaaacc 1202761 tttggcgcga aaacctttcg catcatccgg aagaatttgc tgccgaatac tatgggagcg 1202821 atcatcgtac aaatgacatt aaccgtacct gccgccatat tcgcagaatc atttttaagc 1202881 tttctcggcc tgggcataca ggctccgttt gcaagttggg gcgtgatggc gaatgacggc 1202941 ctgcctacga ttttatctgg gcattggtgg cgcctgtttt ttccggcctt tttcatatct 1203001 ctgacgatgt acgcgtttaa tgtgctgggg gacggattgc aggatgcgct tgaccctaag 1203061 ctgaggaggt agctgtatgg aaaaagttct gtcagtccaa aatctgcacg tgtcttttac 1203121 gacttacggc gggacggttc aggcggtcag aggggtgagc tttgatttgt ataaaggaga 1203181 aacctttgcg atcgtcggcg aatccggctg cggcaaaagc gttacctccc aaagcatcat 1203241 gggcctgctt ccgccttatt cggcgaaggt gacagacggc aggattctat ttaaaaacaa 1203301 agacctttgc cgtctctctg acaaagaaat gagaggtata aggggagccg acatttctat 1203361 gatttttcaa gacccgatga cggcgttaaa ccctacgctg actgtcggcg accagctggg 1203421 ggaagcgcta ttgcgccaca aaaaaatgag caaaaaagcg gcacggaaag aggtgctttc 1203481 catgctgtca ttggttggta ttccagatcc cggagagcgc ctaaagcaat atccccacca 1203541 attcagcggc ggtatgagac agcggattgt cattgcgatg gcgctgattt gcgagcctga 1203601 tatcttaatt gcggatgaac cgaccaccgc cctggatgta accattcagg cacagatttt 1203661 agagctgttt aaagagattc agagaaaaac ggatgtgtct gtcattctga ttacgcacga 1203721 tttaggggtt gttgcccagg tagctgacag agtcgcagtc atgtatgccg ggaaaatggc 1203781 ggaaatcggc acaagaaaag atatttttta tcagccgcag cacccatata caaaaggcct 1203841 gctgggctct gtcccgcggc tggatttaaa tggcgctgag ctgaccccga ttgacggaac 1203901 gccgccggat ttattttcgc ctccgccggg ctgcccgttt gccgcccgct gtccgaacag 1203961 gatggttgtg tgtgacaggg tgtacccggg ccagacgatc agatctgact cgcacaccgt 1204021 caactgctgg ctgcaggatc aacgagcaga gcatgcggtg ctgtcaggag atgcgaagga 1204081 ttgaacatga aaagggggaa gaggatgaaa cgagtgaaaa agctatgggg catgggtctt 1204141 gcattaggac tttcgtttgc gctgatgggg tgcacagcaa atgaacaggc cggaaaagaa 1204201 ggcagtcatg ataaggcaaa aaccagcgga gaaaaggtgc tgtatgtaaa taatgaaaat 1204261 gaaccgactt cattcgatcc gccgatcggc tttaataatg tgtcatggca gccgttaaat 1204321 aacatcatgg aggggctgac gcgtcttggc aaagatcatg agcccgagcc ggcaatggcg 1204381 gagaaatggt ctgtttcgaa agataataaa acttacacat ttacgattcg ggaaaatgcg 1204441 aaatggacaa acggagatcc tgtaacagcc ggagacttcg aatacgcgtg gaagcggatg 1204501 cttgatccga aaaaaggcgc ttcatcggca ttcctaggtt attttattga aggcggcgaa 1204561 gcatataaca gcgggaaagg gaaaaaagac gatgtgaagg tgacggcaaa ggatgatcga 1204621 acccttgaag ttacactgga agcaccgcaa aaatatttcc tgagcgttgt gtccaatccc 1204681 gcgtatttcc cggtaaatga aaaggtcgat aaagacaatc caaagtggtt tgctgagtcg 1204741 gatacatttg tcggaaacgg cccgtttaag ctgacggaat ggaagcatga tgacagcatc 1204801 acaatggaga aaagcgacac gtattgggat aaggatacag tgaagcttga taaggtgaaa 1204861 tgggcgatgg tcagtgacag aaatacagat taccagatgt ttcaatcagg ggaacttgat 1204921 accgcttatg tccctgctga gctgagtgat cagctgcttg atcaggataa cgtcaatatt 1204981 gttgaccagg cgggtctcta tttctatcga tttaatgtca acatggagcc gttccaaaat 1205041 gaaaacatca gaaaagcctt tgcgatggct gtggatcaag aggaaattgt aaagtacgtc 1205101 acgaaaaata atgaaaaacc ggcgcacgcc tttgtatcgc ctgggtttac gcagcctgac 1205161 ggcaaagatt tccgtgaagc aggcggagac ctgatcaagc ctaacgaaag caaagcgaag 1205221 cagctgctcg aaaagggcat gaaggaagaa aactataata agcttcctgc gatcacgctt 1205281 acttacagca caaagccgga gcataaaaag attgccgaag ctattcagca aaaattgaaa 1205341 aatagccttg gagtcgatgt gaagctggcc aatatggaat ggaacgtatt tttagaggat 1205401 caaaaagcgc tgaaattcca attctctcaa agctcatttt tgcctgatta tgcagaccct 1205461 atcagttttc tggaagcctt tcaaacggga aattcgatga accgcacagg ctgggccaat 1205521 aaagaatacg atcagctgat caaacaggcg aaaaacgaag ccgatgaaaa aacacggttc 1205581 tctcttatgc atcaagctga agagctgctc atcaatgaag cgccgatcat tccggtttat 1205641 ttttataatc aggttcacct gcaaaatgaa caagtaaaag gaattgtccg tcaccctgtc 1205701 ggctatatcg atttaaaatg ggcagataaa aactgatgga ggcgattgag gaaatactgc 1205761 ttctttatgc gaaggagcgg tattttttct ctttcttgca cgtatacgta gggtgcagag 1205821 caaatgaaag gagtgttttc gttgaattac aagccgaaag cgttgaacaa gggtgataca 1205881 gtcggagtga tcgcgcccgc aagtccgccg gatccaaaaa agcttgacac cgcgctttta 1205941 tttttagaag agctcggtct tcaggtgaag ttgggcaagg cgctgaaaaa ccagcacggc 1206001 tatttagcgg gacaggatga tgagcggctg gcggatctcc atgagatgtt cagagacgat 1206061 gaggtaaaag cagtgttgtg cgcatgcggg ggttttggga caggacgtat cgccgcgggc 1206121 attgatttca gcttgatccg caaacaccct aaaatctttt ggggatacag cgatattacg 1206181 tttttacata ctgccattca tcaaaacaca ggtcttgtca ctttccatgg cccgatgctc 1206241 agcacggata ttggccttga cgacgttcac ccgctgacaa aagcgtcata taagcagctc 1206301 ttccaggaga cggaattcac ctatacagaa gagctttctc cgctgaccga gcttgttcct 1206361 ggaaaagcgg aaggcgagct tgtcggggga aatctgtctt tgctgacgtc tacactgggc 1206421 acgccatttg aaattgatac gagaggaaag cttctgttta ttgaagatat tgacgaggag 1206481 ccttatcaaa tcgaccggat gctgaatcag ctgaaaatgg gggggaagct gacggacgcg 1206541 gcgggaattc tagtttgtga ttttcacaat tgtgtcccgg tgaagcgaga gaagtctctc 1206601 tcgcttgagc aggtgctgga agactatatt atttctgcgg gcaggcctgc tctgagagga 1206661 tttaaaatcg gccactgctc gccaagtatt gccgttccga tcggtgcgaa agctgctatg 1206721 aatacagcag aaaaaacagc cgtaatagag gcgggcgttt cagaaggggc gctgaagaca 1206781 tgaaaatcat tcgaatcgaa acaagccgaa tcgctgtccc gctgacaaag ccgtttaaaa 1206841 ccgcacttcg cactgtgtat acggctgaat cagtcatagt aaggattact tatgacagcg 1206901 gtgcagtcgg atggggagaa gcacccccga cgttagtgat tacaggagac agcatggata 1206961 gcattgaaag tgccatccac catgtgttga agccggcatt gcttggaaaa agcctggcgg 1207021 gctatgaggc cattctgcac gacatccagc atcttcttac aggaaatatg agcgcgaagg 1207081 ctgctgtaga aatggctcta tacgacggct gggcgcagat gtgcgggctg ccgctttatc 1207141 aaatgcttgg cggatatcga gatacgctgg aaacagatta tactgtcagt gtcaactcac 1207201 ctgaagagat ggcagctgat gccgagaatt atctcaaaca aggctttcaa acgctgaaaa 1207261 taaaggtcgg aaaagatgat attgcaacag atatcgcccg tatccaggaa atcagaaaac 1207321 gtgtcggatc agctgtgaaa ctgcgtttag acgctaatca ggggtggagg ccgaaggaag 1207381 cggtaactgc cattcggaaa atggaggatg cgggcctagg cattgagctt gtcgagcagc 1207441 ctgtccataa agatgatctc gctgggctta aaaaggtgac agatgcaaca gatacgccga 1207501 ttatggctga tgaaagtgtt tttacaccgc gccaggcgtt cgaagttctg caaacccgga 1207561 gcgcagactt gatcaatatt aaattgatga aagcgggcgg catcagcgga gcagagaaaa 1207621 ttaatgccat ggcggaggcc tgcggggtgg agtgtatggt cggcagcatg atcgaaacga 1207681 agctgggcat tacggccgcg gcgcattttg cggcaagcaa gagaaacatc acacgctttg 1207741 attttgacgc gccgctgatg ctgaaaacag atgtattcaa tggcggcata acatatagcg 1207801 gcagcacgat ttcgatgcct ggcaaaccgg gcctcggaat catcggggct gcgcttttga 1207861 aaggggaaaa agagcaatga tgcacactgt catatcagca gtggccaaca tctggacagc 1207921 gcctgattca cctcgtccgt ctgatcaatt catgcttcaa ccgactgtaa tgatcagaga 1207981 ctggctggag cgcatgacgt atgatgaacg gcttggatta tgtacagaca atgtaatcca 1208041 aactcaggtt ctctttggcg aaaaggtact tgtgacggcg gaacaggggg aatgggtttc 1208101 tgtgatcgtg cctagccagc catcccgaaa ggatccgcgc ggatacccgg gctggatgaa 1208161 aaagtaccag ctggaaaaaa caaagcccat ccatacacaa cacgatgtga tgatcagcaa 1208221 acctgctgcc tttttgtaca gaagcaatgg ggaaaaggag atcgaattaa gctttttgac 1208281 agttctgccc cttattgcaa aagaaaacgg atattttaag gtttcgaccg tttttgggga 1208341 aaggtttgtg aggcaaagtg atgcagtgcc tgtcagccaa cagaaaggga ctgctgaaga 1208401 catcattcaa acgggtgcgt tttttcttgg ccttccctac ctgtggggag ggatcagcgg 1208461 gtttgggttt gattgctccg gatttatgta cagtatattt aaggcgaatg gatacagcat 1208521 cccccgtgat gcgggagatc aggctaaggc agggaagggt gtcccgcttg atgatatgaa 1208581 agccggtgat ctgctgtttt ttgcttatga ggaaggaaaa ggagcgattc atcacgtcgg 1208641 tctgtatgta ggcggcggga aaatgcttca ttctccaaag acagggaagt caatcgaaat 1208701 cctcacatta acagagacaa tctatgaaaa agaattatgt gcggtgcgcc gctgtttttc 1208761 agaataagga gggagacaaa tgaggcgact gcctttgtta gaggtcagcc agctgaaaat 1208821 gcattttgac gcagggaaaa agcggacagt caaagctgtc gacggggtca cctttcagat 1208881 tcgtgaagga gaaacgttcg ggctagtcgg ggaatcaggg tgcgggaaat caaccttggg 1208941 gagagtgctg atgcgccttt atcagccgac agaaggaagc gtgacatacc gcggcacaaa 1209001 tcttcatgca ctaagtgaaa aagagcagtt tgccttcaac cgcaaactgc agatgatttt 1209061 tcaggaccct tatgcttcac ttaacccgcg catgaccgtt cgagaaatta ttttggagcc 1209121 gatggagatt cataatctct acaataccca taaagcacgg cttctcgtcg tggacgagct 1209181 gcttgaggca gttgggcttc accccgattt tggcagccgt tatccgcatg aattcagcgg 1209241 cgggcaaagg cagagaatcg ggattgcgag agcactgtcg ctgaatcctg aatttatcgt 1209301 ggcggacgaa ccgatttctg cacttgatgt ctctgttcaa gcgcaggtgg tcaacctgct 1209361 gaagcggctt caaaaagaga aagggcttac gtttttattc attgcccatg atctttcgat 1209421 ggtgaagcat atcagtgaca ggatcggtgt tatgtactta ggacacatga tggaaattac 1209481 agagagcggc accttgtatc gtgaaccgct ccatccctat acaaaggcgc ttttgtcctc 1209541 gattccgatt ccagatcctg aattggagga caagcgtgag cgtattctct tgaaagggga 1209601 gctgccgagc ccggtcaatc cgccaagcgg ctgcgtgttt cgtacccgct gtccggaggc 1209661 gatgcctgaa tgtggagaat ctcgtcccca gcttcaagaa atcgaacccg gccgttttgt 1209721 cgcttgccat ttgtatcgaa atgctgaaac gaaggaaaaa gtaagataaa taaaaagagt 1209781 ggctcctttt tactagagcc actccatttg tttatacttg atgtaaaaac tttacacaaa 1209841 ccgggtaagg gacagaaacc gttgatggga ggagtgtcaa tcggccggtt tctttgtctc 1209901 tttcaaacaa gacaaggttg cctgtttctt catttgaagc aacgaggaac ccttccgttg 1209961 ggtcaaatac aaagtcacga ggccagtttc cttctgtcga cactctttct acgaaagcca 1210021 gctctcctga atattgattc acttcaaata cggcgatact gtcatggccg cggtttgcga 1210081 cataaacaaa acgtccgtcc tgcgtgacat gtattgcgct tccctggctg ttatctgtaa 1210141 aatcatcagg gatggcagaa acgacttgga tttctctaaa ttcgccggct gtcgggttgt 1210201 attcaagcgc aatcacttca ttgcttaatt ctgtcatgac ataagcgtat ttttctttcg 1210261 gatgaaaagc gatatggcga ggtcctgcac cgggagcgaa ggaatggctt ccggattcag 1210321 tcaacacacc gtctttaagc ttataggtgt agagcttatc tatacctaaa tcaaccgcta 1210381 ccacataatt gtgttcaggt gtgaaccccg cgtagtgtgt atgcggtttt tcttgtcttt 1210441 cgtgcggccc ttttcctgtg tgagcggcct ctgaaacagg tgattgcaag ctgccgtctt 1210501 cctgaaccgg aaaaacgtgt accttcccgc tgtgataatt ggcagtcagt acgaattgat 1210561 tttgatcatc aacgcttacg tggcatggcg aagggccatc aattaactga tgattcagaa 1210621 atgtcaattc gccgctgttt ttatcgattt gataggcagc aactccgcct tggccgtctg 1210681 ctttttcgat ggaataaagg atggtgttgt ttttattcgt cgccacatat gtcgggttgc 1210741 ccagcttagc ggccagcttt ggctcgctga gtgctttttt ctcagtatca agctcaaatg 1210801 aataaattcc ttcgcttccg ccttttgtat atgttcccac atatcctatg tattttgtca 1210861 tgcgatttcc cccttaaaaa tgatgtcacc tctatattaa cgtatcttga taaaataagc 1210921 tgttcaaaac atgaaaaagg ggaagattct tcattcgcct cgaatcagcg gcattgtgca 1210981 gcacctgaag gagccgcctg atttaataat ttctgacagg tcaatttcga taatgtgata 1211041 gcctcttttc gatagctgtt gattgacatg gcggttgcca gggagactga tgatcgtttt 1211101 ttttccgatt gaaaggacgt tggtgccaag cgtaaattgt tcgtcctcgg gcacctcaat 1211161 aagatcataa cgttttgcca gcatatcggc tgcatctggc tcaatggcct gtgaataaat 1211221 taacgcttcg ctttcagata taatgttaaa tacgcagtcc aaatgcaaaa atttttcatg 1211281 aagcttcact ggaacgatcg tatattcagg aagtgcctct tctagctggc cgatagctga 1211341 aatgtcggtg cgctggctga ttccgacata gacaatgtca tcatcgataa tgacgtctcc 1211401 gccttcaata ctcgtatcaa gcatgcgggt gtaagagata ccttggctgt gaaaaaaatc 1211461 ttttataacg gcttcttctc cttggcgaat cggttcagtc atgcttgaca gaaaggcttt 1211521 ttctccgatg acaaatccta tgtccctagt aaaaacctgt tctgggagtc cgtcgcgaac 1211581 gggcaaaagg acgacctcaa cgttgtgtga cctaagtgcc tccactaagc ggctgtgctg 1211641 gtcgttagcg gtttttacat gaatattgtc atcttcaaaa tgtttttgtg tttcgtttat 1211701 aacatctttt atggtcatgt gctcaggttt gcataagatc actttttgaa gtgtgccgta 1211761 ttccgttcgg cataccgttt tgtgctgaga tttcgggatg gatacgtcca tttgtttttc 1211821 ctcctaaagt gtgaagaata catttattat tccctcatca tgaaaatcat taaaccattt 1211881 taaattttag acaaatggaa gagaatattg tttaatagga gaatataagt gcatttagct 1211941 aaaagatcag acatcaaagg ggagaaaggt atggaaacac cggaaacaag attttgtaaa 1212001 gagtcaaagg ttgtgaaaac cagcagggtg ttcccgcttg acacgaacaa ccataatacg 1212061 ctgtttggcg gaaaattaat gagctacata gacgacattg cctctatttc agcggcgcgc 1212121 cattgcagac gtgaaacggt aacagcttca atggattctg tagatttttt aaagccgatc 1212181 gggcaaaagg attctgtctg cctagagtca tatgtgacat gggtcggcac atcttccatg 1212241 gaagtatttg tgaaagttat taaggagcat ttgatgactg gcgaacggga actcgctgcc 1212301 acatcctttt tgacatttgt cgcattagat tcaaatggca agccggtgcc tgtaccgagg 1212361 gttgtaccgg aaacagaaga agaaatcatg ctgcataata cagctgtaca gcgtgctaat 1212421 gaacgtaaga accgcaagag acacagccag gcgcttgcaa atgcgctcgg aactgataag 1212481 ccttggtgaa cgttaaaccc aaaacataag ttgttttggg tttttttgta cttttcaatg 1212541 gtgattatta caatggttag tccgtttttg ctaggggatt ctataaaaaa gcaacaaatg 1212601 tcatgttaaa ttgataattt tgtgacaact ttattaaaga ttcattttag atatatcttt 1212661 tattcgtaag atcatgtatt ttaaagatat attttaaata catcttttcg aaaggattgt 1212721 ttataaaatg ttagataaca aaacaatcga aattattaaa agcactgtac ccgtattgca 1212781 acagcatgga gaaacaatca ctggccgttt ttacgatcgg atgtttcaag accatccaga 1212841 gcttttgaac atttttaatc aaacaaacca aaagaaaaaa acacagcgaa ctgcactggc 1212901 aaatgccgtt attgcagctg cggcaaacat tgaccaatta ggaaacatca ttccggttgt 1212961 caaacaaatc ggccacaagc accgcagtat cggaattaag cctgagcact acccaatcgt 1213021 cggtaaatat ttgctgattg cgattaaaga tgtattggga gacgctgcaa ctcctgacat 1213081 tatgcaggca tgggaaaaag cgtacggagt cattgctgac gcgttcatcg gaattgaaaa 1213141 agacatgtat gaacaggctg aagagcaagc cggcggctgg aaggagtata agccattcgt 1213201 tatcgcaaaa aaagagcggg aaagcaaaga aattacatcc ttctatttga aaccggaaga 1213261 cagcaagccg ttacctgaat tccaagcagg gcaatatatc agcatcaaag tgcggattcc 1213321 tgattctgaa tatacgcata tccgccagta cagcctgtct gatatgccgg gaaaagacta 1213381 ttatcgaatt tcagtgaaga aagatggtgt cgtgtcttcc tacttacacg atgggctgca 1213441 ggagggagat tcaatagaga tcagcgcacc ggcaggggac tttgttttag atcatgcatc 1213501 acaaaaagat ctcgttttga tcagtgccgg agttggcatt acaccaatga tcagcatgct 1213561 gaaaacatct gtttccaaac agcctgaacg gcaaattctg ttcattcatg cggcgaaaaa 1213621 cagtgaatat catgcattgc gccatgaagt agaagaagca gcaaaacatt ctgctgttaa 1213681 aacagcattt gtgtatcgcg agccgacaga ggaagaccgt gcaggtgatc tgcattttca 1213741 tgaaggacag attgatcagc aattcctcaa agaactgatt gccaacacag atgcggatta 1213801 ctatatttgc ggttcaccgt cgtttattac ggcaatgcat aagcttgtat cagagctcgg 1213861 atcagcgccg gagtctatcc attacgagct attcggcccg caattaagtt tggcgcagtc 1213921 cgtttgaaca catacatgaa actcttctcc tttcagagaa gagtttttta ttgagatata 1213981 agaaggcaga caagcgccgg tttctacatc cggacaatca cagacccgct gccatttgtg 1214041 catacacggt tttgctgttc ttgcattgtt ctcagcaatt cattgtttac ctcaatcgct 1214101 ctaattagtt gcttcattct tagctccaaa ccggccagcc tgtcgattgt ttgctgctgg 1214161 tagccctcgg gttggggagc caatggcaga tcaaagggcc aaagggtatt cgacttctga 1214221 tttttcatat tgcgtattgc gcctccaatc ggtgtcactt tctattatgt tatgttcagg 1214281 cgatatgcac gttcgcctag acactgatgc atagagggcc tgccacgggg cacaataggc 1214341 tcaatatgac cagcggatgg aggtaaagat cggtgttatg gatggtatgg gtatttttac 1214401 tgaagccagt tatcgtattt tcgattgcat atattttgtt tcggcttgcc ggtaaaaaag 1214461 ctgtgtcaca aatgaacaat tttgacctgc ttttgacctt cgcaatcgga accattatca 1214521 gtgagccgat ccttacatcc aagctgccga tgtcaattta ttatgcgggt gcttttttgg 1214581 tgctttatct tatcatgagc aagctctctt tatctaataa atggcgatgg ctcctagtcg 1214641 tgagcccgac tgtcctaatc cgaaacgggg atattgatga acgcggcctt cgtaaagaaa 1214701 ggctgactgt taatgagctg ctcggaaagc tgagggaaaa gggctatgcc gacccggctg 1214761 acattgatct tgctatcatt gaagaaacgg gagaagtaag cgtcatcccg aaagaggaag 1214821 cgagagcggt gcaggtgcgg gatttgaata tggaagctga acggaatttt atcccgattc 1214881 cgctcatact ggatggcgaa atccttgatc ataatttgaa atatctccaa aaaaaccgat 1214941 cctggctgtt tgagaagctt gaggaaaaag ggtacagccc caaactgctg tcttcgatta 1215001 tccttggcac gatgaatgca cgcggtgata tatcccttga tttaaatacc gctaatgaac 1215061 cgcagcatga tccttactta tataaaccgg gaaataacaa ttaagatggc tctctcttgt 1215121 aatgagagct tttttctttt ttaaagggaa tttttgtttg gtgtcaaatg tacctagtta 1215181 ggaggggaac tgaacatgaa ggacttatcc ataagaaacg acatggcgcc aacggtcagt 1215241 ttgctgtatt ccgcagtgga agaaaacagt ctccgtctgg cttccatcgt aagccatatg 1215301 acacacagtg aactttacta taaggggcgc tgccaaacaa aaaacagcac ggctcagctt 1215361 ttgcaccata tcacaaatgt tgatatcaga tgggtctggc gtatcaagga aaatcggatc 1215421 ccggaccata ttgaacaggc atacggcccg atgacagatg aaagcggacg gctgcctgaa 1215481 ccggtgaatc agccagactt agatgaactc ctgaaaagac atcagcatgt agtagagaag 1215541 ctgaaatcgg tatgcttcac tttaactgaa aatgctttga accagccgct ttccttcgaa 1215601 ggtgacaccg cgacgatacg atggggaatt tggcatatgg cagatcataa ccgctatcat 1215661 caggcacata ttgaagctct caaaaaagaa tggaagcagg atgtggcgaa gtatgaacgc 1215721 taaaacgaag cttgtgactg atcgaattcg tttgcgctgt atggaagatc gggatcaagc 1215781 cactttgttt gggctgcttt ttaatgatcc tgacgtcatg acatattatt ccggtttaaa 1215841 agataagagg caaacccgcg agtgggtcaa ttggaaccaa cgaaatgaaa aagggtacgg 1215901 cgttagtctg tggatcgccg aagataagcg gacaggggag tttttggggc aatgcggcat 1215961 cgttccccag cagatcgaaa atcaaaccgt aatggaaatt ggctatatgt ttgcccgccg 1216021 ccactggggg aacggctatg cgcaagaagc ggctcgggcc tgtctggact atggctttaa 1216081 cgagcggcag ttcggcaaaa tggcggcttt gattgatccg ggtaacaaag cgtccatacg 1216141 ggtagcggag aaaatcggca tgcattacag caaaacgatc agaaaatgga ataaaccgat 1216201 cgcggtatat gaaagaaaat cttacaattg aaagatagag ctgagtttag tatcatgata 1216261 tcatgtaaag ttttctaggg ttccgcatgt caattgacat ggactggtcc gagagaaaac 1216321 acatacgcgt aaatagaagc gcgtatgcac acggagggaa aaaagcccgg gagagtcaat 1216381 ctcatgtgag acgactgtcc ggggtttttt tgttttcgga gaatcttaat agatagaaag 1216441 gaatgactca aaatgaaatg gggattggtc gtgcttgccg ctgttttcga ggttgtttgg 1216501 gtgataggct taaagcacgc tgactcagcc ttaacatgga gcggcactgc catcggcatc 1216561 atattcagct tttaccttct aatgaaggcg actcacagtc tgcctgttgg taccgtgtat 1216621 gccgtcttta ccgggctcgg cacagcggga acagtactta gtgaaatcgt tctttttcat 1216681 gaaccggttg gatggccgaa gctattgtta attggcgtgc tcttaatcgg tgtaatcggg 1216741 ttgaagcttg tgacacagga tgagacagag gaaaaaggag gcgaggcata atgctgcact 1216801 ggatcagttt attgtgcgcg ggctgtttag aaatggccgg cgtggccctt atgaatcaat 1216861 atgcgaaaga aaaaagcgtg aaatgggtgc tgttgatcat tgttggtttt gccgcttcat 1216921 tttccttgct gtcgtacgca atggaaacca ctccgatggg aacggcttac gcggtctgga 1216981 caggaattgg caccgccggc ggggcgctta tcggcatcct cttttacaag gagcagaaag 1217041 acgccaaacg gatcttcttt atcgcgttga ttttatgctc agcagttggt ttaaaaattc 1217101 tgtcataaat tgatttttat caaatcttca gtataatgga taaatagttt agacttacaa 1217161 agataagagg gattattcat gaaatcatat atgactcagc ggttggacga ataccgtgac 1217221 ggaaatgagg ataaaggtcg gctcttggtc agctgccccg atcagccggg tatcgtctct 1217281 gcagtttccg cgtttttatt tgaacacggt gccaatatta tagaatcaaa tcaatatacg 1217341 acagaccctg aaggcggccg gttcttcctg agaatcgaat tcgactgcgc aggcattcgt 1217401 gaaaaaaaat catcacttca ggcagcgttt gcctctgttg cggaaaaatt cgacatgaca 1217461 tggagcttaa ctttggcgag cgaactgaag cgtgtcgcca ttttcgtttc aaaggagctc 1217521 cactgcctgc atgagctgat ttgggaatgg caaaccggca acctgatggc ggagatcgct 1217581 gttgtcatca gtaaccatga ggaagcgaga gagctggttg agcgcctgaa cattccattc 1217641 cactatatga aagcgaacaa agacatcaga gcggaagtcg aaaagaagca gcttgaactg 1217701 ctggagcagt acgatgttga tgtgatcgtg ctcgcacgct atatgcagat tctaactcct 1217761 gattttgttt cggctcatcc gaatcgcatc atcaatatcc accattcatt cctgccagct 1217821 tttatcggtg cgaatccgta caaacgggcc tacgagcgcg gcgtgaaact gatcggtgcg 1217881 acatctcatt atgtgacaaa cgatcttgat gaagggccga tcattgaaca ggatattgag 1217941 cgtgtggacc accgcgataa tgcggaagcg ctgaaaaaca tcggaagaac aattgagcgc 1218001 agcgtgcttg cccgtgctgt gaaatggcat ttggaagacc gtgtcatcgt tcatgaaaat 1218061 aaaacaatcg tctttaacta gactgcaaga ggcccgcgca atgcgggcta tttttgatga 1218121 caaaaaacct tgacaagtgt cttttttctt tgcataatat aaaaaaatca ttgagcgttg 1218181 aagaggatta gtaagcagac ctttctgtga cagagagcaa aatgaatcgc tgaaacattt 1218241 tgccgcatga aacctgccga acctgccttg gagtcctagg gggaaaacct aggcgcataa 1218301 cctggcgtta caggagagcg gagcgtgcac aagcgcgttc aatcaaggtg gtaccacgga 1218361 aacccatttc gtccttatga atcaggatga aatgggtttt tttattgtag aagagccgcg 1218421 gaggagaata aatgaaaaaa caaagaatag tagtgaaaat aggaagcagt tcgctcacga 1218481 atagcaaagg aagcattgat gaggcaaaaa tcagagagca tgttcaggcg atttccgtgt 1218541 taaaaaaagc ggggcatgaa atgattctga ttacctcggg tgccgtagcg gcggggtttt 1218601 ccagcctcgg ttatccatcc cgtcccgtta ccatcaaagg aaaacaggcg gcggccgcgg 1218661 tcggacaaac actgttaatg cagcaatata tgaatcaatt taaacaatac tcactgactc 1218721 cgggacaaat ccttttaacg agaaatgatt tttcgaaaag agaacggtat cgaaacgcgt 1218781 atgctacgat aatggaatta ttagagcggg gcgtcattcc gattatcaac gagaacgatt 1218841 ctacatctgt tgaagaattg acattcggag ataatgatat gctttctgcg ttagtcagcg 1218901 gattgattca cgcggaccag ctcatgattc tcactgacat taacggactg tatgatgcca 1218961 atccaaatga aaatcctgag gcgaaacgat ttgattattt gccagagatc acgcctgaat 1219021 tgcttggata tgcaggttca gctggatcaa aggtcggcac cggcggaatg aaatcaaagc 1219081 tgttagccac acaaaccgcg ctgtctctgg gagtgaaagt attcattgga actggcagcg 1219141 gagagcaaaa acttgcggac attttggacg gcaggggaga cggcacttat atcggagaca 1219201 aagaactatc ttcggttaac aacacaaggc agtggattca gttccactcg ccgatatcgg 1219261 gagaaattat cattgatgcg ggtgccgaag aggcgatgat ccataatgga agcagccttt 1219321 tgcccgctgg agttgtgggc gtgaacggaa gctttccgaa aggggcggtt gtggaagtca 1219381 ggggaccggg cggcgtgatc ggcaaaggcc aaactcatta ctcctccgag gagattatgg 1219441 aggctaaagg caaacgcagt gacgaacttg attttgagaa aacgtttgag gttattcata 1219501 ggaatgactg ggtcaatgta aaagactagg aggcggaaaa atgagtgaag tttctgtaaa 1219561 agcgaagctg gcgaaagaag cagcagccga aatgatcatg aaaacaacag ccgagaagga 1219621 tgaggcgctc agcctcattg caaacggact ccgcaaagaa ctggattttc tcttggcgga 1219681 gaatgcaaaa gacattgtga acggaaaaga gaatggttta acaccggaca tcattgaccg 1219741 tctctcattg gatgagaaac ggatacgcga tatcgcggac gcggtggagc tcttaatcga 1219801 cttagcggac ccaatcggcg actctcttga aacgattgaa aaagaaaacg gcctgtttat 1219861 tgaaaaaatc cgtgtgccgc tcggtgtcgt aggaatgatt tatgaggcga ggccaaacgt 1219921 cacagttgat gcggctaccc tttgcctgaa gacagggaac gcggttgtgc tgcggggaag 1219981 ctcctcagcc atccacagca acaaagcgct cgtcagtgtc atttacagag cacttgagca 1220041 atcagcgctt ccgattcacg ctgtgcagct gattgaggat acgagcagag agacagcaaa 1220101 agagctcttt acgttaaatg atggcttaga cgtattgatt ccgcgcggag gcaagaaact 1220161 gattgatctc gttgtgagag aatcaacagt tcctgtatta gaaacgggag caggaaactg 1220221 ccacatattc attgacgaaa cagccaaacc gcaaatggca gaaaaggttg ttgtaaatgc 1220281 caaaacgcag cgcccttctg tatgcaacgc gattgaatca ttgctgattc acaaggcttg 1220341 ggcaagacag cacggaaaag aattgctgga ccagctggaa aacgcgggag ttgaaattcg 1220401 cggtgatgaa ttggtatgtg aacttcatcc ttcaagcaaa caagcatcaa aagaagattg 1220461 ggaaaccgaa tttttagcgc ctgtcctcag cgtaaagacg gttgaaaacg tccaagaagc 1220521 tgtaaagcat atccaacaat acggcaccaa tcattctgaa gcgattttaa ctgaaaatga 1220581 caaaaatgcg gtatattttc aaacggctgt cgatgctgcc gctgtctatc ataacgcgtc 1220641 aacccgcttt accgacggct ttgaattcgg ctacggagcc gaaatcggca tcagcacgca 1220701 aaagcttcat gcaagaggac cgatggggct tcctgcactg acttctacaa aatacatcat 1220761 taaaggaact gggcaaatcc gtgaatagcg gggtaatgtt caatgaaaaa gcttatctca 1220821 ttacgagata agctttttta tacgcgaaaa attgacattt caaatttaat tgtgtacaat 1220881 ttaattgtat aaaatatatt gggggaatga aaaatgagtc agccattatt taccgcaact 1220941 gtttcagcgg taggaggaag agaaggaaag gtcatttcat cagaccgcgt tcttgagctt 1221001 gatgtcgcaa tgccggggac accgagagcc aagaaattag aaaaagcgac aaatccagag 1221061 cagctgtttg cagcaggtta tgcagcttgc tttgacagcg ccctgcagct tgtcgcaaga 1221121 acagaacggg taaaagtaga gacagaggtt acagcaaatg ttagcctgtt aaaggatgaa 1221181 gcggaccagg gctataagct gggtgtgacg ctgcaagtaa aaggagaagg agtcagtgca 1221241 tcagaattgg aggcgcttgt gaaaaaagcg cacggcgtct gcccgtactc aaaagcaacc 1221301 tccggaaata ttgatgtgac acttgaagtt gctgaataaa taaaaagagg atgcctgtac 1221361 aaggcatcct caattttttt gatgaagtgt ttccagtaat gtatatagag cggactttaa 1221421 ctgtttgaga tcctccccag actgctttga gagccccaga attgtccctg gaatgtcaac 1221481 cgctttttct tttaataacg ctccgtcctc tgtcaggctg atcaacacgg accgctcatc 1221541 ctcttcagat ctttttctcg taatcaaacc ctgttgttcc attcgtttaa gcatcggagt 1221601 gagcgttcct gaatctaaat acagctgttc gcccattttt ttgacagtaa gcgtttcatg 1221661 ttcccataac aaaagcaaag ccaaatattg agggtatgtt atattcagct tatcaagcag 1221721 cggcttgtat tgctttgtca tctcccgcga actcgcatat agcaaaaaac aaagctgatt 1221781 ctccaatttc atatgatcaa atttattttc cattttgttc accaactctt ttttgtcatt 1221841 cgattctatt gtatctgaaa aacctcactt ttcctattct cggcaaacat agcatgttta 1221901 aaaagatcag aaagggaaat ataacaacta gatacaaata aggaggttgg gaaatatggc 1221961 actatttaca gcaaaagtaa ccgcgcgagg cggacgagca ggacatatta catcagatga 1222021 cggtgttctt gattttgata ttgtcatgcc aaatgccaaa aaagaaggac aaaccggcac 1222081 aaatccggaa cagctctttg cggcagggta tgctgcatgc ttcggcggcg cgctcgaaca 1222141 cgtagccaaa gagcagaata tcgaaattga ttcggagatt gaagggcagg tcagcctcat 1222201 gaaggatgag agcgacggcg ggtttaaaat cggtgtcaca cttgttgtga acacgaaaga 1222261 tttagatcgg gaaaaggcac aagagcttgt caacgccgct catgaattct gtccttactc 1222321 aaaggcaacc agaggaaatg ttgatgtaaa actagaatta aaataatgac cggcatcctg 1222381 aggattctca ggatgttttt tggtgtcgga catgcggggc gggcacagat ttatgataaa 1222441 acttcagaga agcgtttgaa gcatgccttt aaaccaaaag ttacagatga agcgggtggc 1222501 tggcacggtg tctgccgtgc tgaattgcgc gtatatgctg ttttgtattt gcacagggca 1222561 tagcggctac ttggagaaat aacaaggacc aggccgcgca tgcctgatcc ttttaatatt 1222621 ctttcttatt ggcgaagttc cgccatgctt gaaacgggga taaatgctct gttagtgtca 1222681 cttgataaaa ggggatcgtt ctttcttcag caggtttatc aatttcttta taaatgaatg 1222741 aatcatcaaa cccggcttcg gcagcgtctg tgtgctcagc tgcatagaaa acggctttag 1222801 gccgggccca gtagatggcg cccaagcaca ttgggcatgg ttcacagctc gtatacaaaa 1222861 tgcagtcatc aagctggtag gctcctagca ccttacaggc tttccgaata gctgtgactt 1222921 ccgcgtgggc agtcggatca ttgcttgttg tgacgttgtt ctgtccctct gcaataatgg 1222981 ctccgtcttt cacgataacg gctccaaaag gcccgccgat tcctgcattc actccttcac 1223041 atgcgagagt gacagcccgt tttaagaacg tttcatgatt catcccaatc cctcctgtca 1223101 atagagtgtt attagtatag ccgaaaagaa tgcaaagaac attcttaaaa aagtgcaaaa 1223161 taaacaaagt atttggggga tttgctaaat aagaaaccga ttgtggctgt attatagaaa 1223221 aaaaccatct gccaaatgca gatggttttt tcaaattata ctagctgtgt ctgctgtgct 1223281 cttgcctgtt ttgcggcttc aaccatattt ttcaatgctg caaccgtttc ttcctgctgt 1223341 cttgttttca atccgcagtc tggatttacc cagaagcggt cagtcggaca gacggcaagc 1223401 gcatcaacga taatattgta catttcttca gttgacggca cacgagggct gtgaatgtca 1223461 tatacaccaa ggccaagccc tttcaaatac gggtggtttt ttaagtaatc taaaaatcct 1223521 ccgtggcttc tgctatgttc gattgtaatc acatcggcat caagatcatt gattgtatca 1223581 acgatatctt cgaagttgct gtagcacata tgtgtatgaa tttgtgtctc gtttttcacg 1223641 gaagaagtgg ttaatctgaa agcttctgcc gcccaagtca aatactcatc ccaatcgcgg 1223701 gttttcaatg gaaggccttc acgcagcgct ggttcatcga cttgaatgat ttgaatgcct 1223761 gcgtcttcaa gcgctttaac ttctttgcga agggcaagcc cgatttggaa ggcgatttct 1223821 ttcctcgaga tgtcgtttcg agggaaagac cagtttaaga ttgtaaccgg gcccgtcagc 1223881 attcctttca catgcttgga agtcaatgac tgtgcgtaga ctgtgtcttt cactgtcatc 1223941 ggttcaataa attcaacatc tccgtaaatg actggcgggc ggacacagcg tgagccgtat 1224001 gattgaaccc aggcatattt agtgaaggcg aaaccggcca gcttttcacc gaagtattcg 1224061 accatgtctg tccgttcaaa ttcgccgtga acaaggacat caagctccaa ttcttcctga 1224121 atatcaatcc atctttttgt ttccgcattg ataaagtttt gatactgttc atcggaccac 1224181 tcagctttcc gccatttttg gcgtgcgctc cgcacttcag cagactgcgg gaagctgccg 1224241 atcgttgtcg tcggcaaaag cggaaggccg agagattcat tttgtagggc taaacgttct 1224301 tcaaacggaa tcgggcgctt gaagtcttta tcagttaatt gctcaagctc tttcttttgt 1224361 tcagaattgg cgcctgttgc aaactgttta agcgcctgga tatcagcctt agcctgctga 1224421 atctcttcgc tgatcgccgc ttttcctgat actaagcctt ctttcaaagc tgtcagctcg 1224481 gccagctttt cttttgcgta ggataatccg ttcaataggt ctttttccaa atgctcatca 1224541 gggtgtttcg ctactggaac atgcagcagg ctgctggaag gctgaatcca cagttcatca 1224601 acttttgcaa tgctgagaat atcaagaacg gcatcgagac gctcttcaag gtccgctttc 1224661 caaatgttgc gtccgtcgat aacgccggct gccagcactt tatctgtcgg gaagccatgt 1224721 gttttaagct gttccaggtt tctgcctttg tcgtgaacga aatcaaggcc aattccctga 1224781 accgggtaag agatcagctc ttcataagca tcaacagaat caaaatacgt ctgcaaaagc 1224841 acattcaagg atgaaagctc acttgtaatg ctttcaaata attcttttgc gccgcgtaca 1224901 tcttcactag aggcggtaac gagcgccggc tcatcgattt gaacccattt tacgccttct 1224961 tcttcaagct ctttcaaaag ctgtacatat aatggcacaa ggcgtttttg gatcgctttt 1225021 gcttcagacg gttcatagcc tttagcaagc gtaacgaacg tataagggcc gacaatcaca 1225081 ggctttgttt ccacaccgta ttcctgtttg atccggcgat aatcttcgag ttgtttgttt 1225141 cttgtcagac ggaactcaat gctctcgtca tattccggaa cgatgtaatg gtaatttgta 1225201 ttaaaccatt ttgtcatttc actagataca gcgtctttga ttccgcgggc gatagcgaag 1225261 tatgtatcgg tagcgtcagt caaatgtctg aaccgtttcg ggatccagtt gaagctgact 1225321 gctgtgtcga gtacatggtc atactgtgtg aaatcagaaa caggcacaac atcaatctgc 1225381 tggtcaattt gtgtttttac tgcggataaa aatagttcgt cgatttgctt caaaaacgta 1225441 tctttatcag tactgccttt ccaatacgct tcaagtgctt ttttccattc ccggttcagt 1225501 ccgattctcg gaaatcctaa attcgatgtt ttgatggttg tcattgtttc tcctccttta 1225561 tatgtaaaac actctctttc acccgcggat acaggctgct aagaggtttt ctcacaacaa 1225621 aaagcctctt tcccatgaga gaaagaggct tttctacgta aaacactgcc tctctcatct 1225681 ctcagacaca atctgatgga attagcaccg tgccttatga gacatcagtc tcggcgcgaa 1225741 aagcagtgcg ccccatttca caatggtatt acggtcggtt gctgttgggg tcaaaaggcc 1225801 aatccctcgc ccaactctcg ataagagaaa atgttattaa ttttttgaaa agttgaatca 1225861 tttgttggta atcttaacag taattcaaat tcattgtcaa catagaattt gaaattttta 1225921 tttacatgat gtggtgtata ttatataaga aaaataatct tatagggtca acaaatgtga 1225981 ttgctctgct ttttctgcga gctcatcagg agctgttaaa tacaggaatc cattgcctgc 1226041 cagcgttttt gcaatatcaa gaggaagtgt cctgcggatt agctgtgcga aaacctcaga 1226101 ttcagaaagc tttctttgaa atgattcttc ttcatagctt ttgattaaag caagcgcacc 1226161 gctgacatga ggggcagcca ttgaagtgcc ggtcagctta ccgtacttct tgttgggaag 1226221 ggtggataag atgttttctc ctggtgccac aaggtcaatc tctttattcg cgttagaaaa 1226281 ttctgataat tctcgcgcta cagaaacaga tccaactgca atcacttcat tataagctgc 1226341 ggggtaggaa agctcttctg tgcgttcgtc gccgtcacct tcatttcccg ctgcacaaac 1226401 gacaagcact ccgtttttca ctgcgttttt cactgcttct tttagctctg gcacatcgct 1226461 tggccctcca agggacattg agatgatgtc gactttctgt tccaccgcgt agttgatgcc 1226521 gttaattatc cattcgtatt gtccgctgcc gttctcgccg ccaagaacct tcacaatcaa 1226581 taggcttgcc tcaggcgcga ctccggcaat gcctccgttt gaatcattag ctgcaattgt 1226641 tccggcgacg tgtgtgccgt gtccgttgta gtcggaaatc gcatcttcct tgccgccgtc 1226701 gtcatccgtg aagttctttc cgccgatgat ttgatttttt aaatcagggt ggcttgtgtc 1226761 gcagcctgtg tctaatacag caactttaat atttttgcct tttacccctt ttgcccacat 1226821 ttctggcgcc ttaatcactt taatgccctc aggaagctcg tttacatcca tgatctgctc 1226881 attcgtcaca tacgggatca agcggatttc accattcata aaaaagccct ccttttttat 1226941 gcttgcaagt ggattcaagg gtgttgcctc atattatatg aaaaaagcaa gcgctcggac 1227001 agagccattt gaagcatttt gaaaaaatag gatacacacc aaagaattag taatcttcaa 1227061 aatattggat ggcttcaaca tgtatgactg ggattcaact gtaagtcaag ttataatagt 1227121 gttggggaaa ggagcagtgt catgaaactg aatgaaaaat tatatgcatt tttttcagag 1227181 catgtggaac aaatggccga ggaatggatt gaaacgatgg aggaaagtga tccgaattcg 1227241 ctttacgccc tacataatgc aacagtaacg gaagaattga aagagcagga cagagaattt 1227301 taccggcatc tgaattacat gtatgtttta ccggaaaaac aatttctcga agagtttcaa 1227361 gagtgggtca ttgagctgac caacgatcaa aaacatctcg acacaccggt tcagtatgtc 1227421 attcgggagt ttatgagaaa caggagatta tatacgaagt attttgagaa gttcgcagaa 1227481 gaaaatgaat cagcgtttga accgggagag aagcaaaaat gggcagattt gattgtaaaa 1227541 gtatttgatt tcaccattta tacattcgtt gatcacgctg aaatgaatgc caagcagcaa 1227601 ttaaacgccc aaagagaaat gatattggaa ttaagctcac ctgtcattac cctgagcaaa 1227661 tcaacagctc tgctgccgct tgtcggtgac attgataccg aacgggcgaa gtttattctg 1227721 gaaaacacgc ttcaagcttg tgcgaaaaga cgtgtggagc atctgttaat cgatctgtca 1227781 ggtgttgttg tggtggatac gatggtggcg caccagatct ttaaattgat tgaggcgctt 1227841 aatctgatcg gtgtccggtc aaccctgtca ggaatcaggc ctgaaattgc gcaaactgct 1227901 gtacagctgg ggattgactt ttcgaatatt actattaaaa ccaaccttgc ccaagcatta 1227961 aactatcatc aataaaaaaa tccgctatct gtgatagcgg attttttatg atgcgaaaca 1228021 taaagatacg agaaaggatc ccgcgaataa taagaggacg aggcaaaaga acacccagtc 1228081 gcgccggttc acgctcaatg tcctgtagta tgtccggttt ctgcttcctg taaatccttt 1228141 cgattccatc gcaagcgctg tccgttccgc ttttctgatg gcgcttgcca atagcggtat 1228201 ggtatatcgt tttaacgcac tgattttatt aatgatgccg ctctccgccg ctcctcctct 1228261 gattttatga gcctgctgaa tcagctggac ctcatccttt aacagcggaa gaaagcgaaa 1228321 gcctgcaatg acaccgtacg cgagctttgg tgagagcctg cactgctgga caaggctcag 1228381 cataaataga atcggatcgg ttgtaaaaac aaacatcatc gataaggcgg aaaagcataa 1228441 aatacgaaac ccgagagaga tgccgacaga cacattatcg ctgttaatgg agatagggcc 1228501 tgcttgaaac aaaaaattat ccggtgttgt cggcactttt ccaaaaactg cggctgtcca 1228561 cacgcatccg aatgctaaaa tcaaaaacgg aatcgtaaac aacaaccatt ttttcaatgg 1228621 gattccggcc gccagtaaaa cgcccgcaac gatgatgata taaaaacatg ccggagtgta 1228681 agggttgtaa ataaacgaca gcatgacgac acaacaaaaa accgccgccg ctttcacagt 1228741 cggattaatg agatgtaacg gttgcttcat cacgcacctc ctcttgaaat gccatccatt 1228801 catatagaag gggaagggtg agctttgctt tttgaacaag ccctgtttct tgagaaaaca 1228861 actgcgctgg agatccgtca aaggccaggc ctgtatcgtg aagcacaagc acgctgtcag 1228921 catacgaaga gactagctcc atatcgtgtg taatcataag gacagcagtt ccctctgcct 1228981 tgatacgttg aatcatttcc atgcattcag ccgccgtgcg ggcatcctgg ccaaaggttg 1229041 gttcgtctaa taataaaacc tttacgtcat gcatgagcat agtagctacg ctcagtcgcc 1229101 gtttttgccc ttggctgatc gcaaacggat gatgatcagc caaatgcgca agaccaaaac 1229161 gctgcagcag gtgttgcgct tttttctcag tttcagcatt tgctttctgg ccgaacagaa 1229221 gctcgtcata caccgtatcg gtgacgaatt gatgctcagg gttttgaaaa acaaatccca 1229281 tccgtttacg caattctttt tctttatatt tctgcagcgg ctgatcatag agaaggattt 1229341 tgccgctttg cggtttcatg agactggcca gaactgatag gagcgtcgat tttccagttc 1229401 cgttcggacc gacaagcgcc gttaaagagc cttcgcgcaa cgaaaagctg atgtctttga 1229461 aaatcgcctg ctgtcctctc gcgaacgaaa ggctgctgac ttcaagcaca ctctccccag 1229521 aaggggcttt cttctttttg acatgcccgg caggaatagg ctctttgaac agcatctctt 1229581 ttgataaagt aaacggcata ctcagctttt cctgcagatg acagaccttt ggaatggcga 1229641 tgcccaattt ctttagtgtc tccgcttcat gctgaaatag atttttcgtc aggccatcca 1229701 gtgccttttt gcctgatttg tcgagtacga tcgttctctc aatccaaggc gcccattcat 1229761 caagctggtg ctcaatgacg aggaggctga aacctttttc ccgctgaaga tccttcatca 1229821 gatgaacgaa ctcccgagct gagaaagggt ctaaaagaga ggtcggctca tctaaaataa 1229881 taagctcagg ctccatcgcc aaaatacagg cgagagccac tttctgcttt tgtcctcctg 1229941 aaagggttga gatcattttt tcttttaaat gggtaatgcg taatttttct aatacggcgt 1230001 tgattttctc tgtcatttct tcttttggaa tttgcagatt ttccagcccg aacgctattt 1230061 cgtcctccac cgtcagcatg cagaactgct gatcaggatc ctgaaaaacg accccggcat 1230121 gctgagtaat cgtttcggag gtttcagcat ctgtgaccgg cttttgaaat agaaatacat 1230181 gtccggactg aatgccgtcg caagcctccg gatatagacc gtttaaacaa agggcgagcg 1230241 agcttttacc gcatccgctc ggtcctaata ataaaacaca ttctcctttt tgaagctcaa 1230301 acgaaatgtc ttgaaaaacc ggtttctcgt cttcttcata agagaagctg agctgctcaa 1230361 ccgtcagaag ctcatcaaag gcttgcatgt tctgacgccc gcttccgttt ctttttcagt 1230421 tcctttccga gtgccattcc gtttaacaca cctgtataag cgagagagtc gctgacagct 1230481 tttccgagaa gccccgccaa aagcgcgccg gaaatgaggc ggatcacaag cataatgagc 1230541 agataacctg gtgaataggc tgcatagcca gaaacaaaga gatcatagat aaagctggct 1230601 actgaagacc ccataccggc cagcataagg acagggagag agtatgcttt ccagcgtgtt 1230661 gcaagaaata cagcctcagc cccgagccct tgaacaatgc caatgacgat gaccatcggg 1230721 ccagacggat ttcccagcag gcactcaacg agagcggcaa tgatttcaga aacgagcgcc 1230781 gcacccggtt ttcgaatcat gtacgcggcg atcacagaaa cgataaacca aatgccgtaa 1230841 attggttcat aggcgattgg cccaaacata cctgcaagta cgtttccgaa atgtgtaaat 1230901 aataaataaa caacggcaaa tacgatactg ataacggaca tgatgacaat ttcttttact 1230961 ttccagcttt tcatgttatc cctgctttct gttttttctt gatggactgt tagccgaaag 1231021 attcacagtc atggtgatgt ggtttgtttg ctgctcagcc atgcggaaaa cggcctccaa 1231081 tgtgctgaat acgtcatgcg catccccgtc aagctcgctc gcgtaatgga caccctgtac 1231141 gaaagtgcct tgggcttttg caatgtcgac agcctccata atcaatccca tataatccgg 1231201 ctcattcatt ggataaaggg caaattggca cggcgcttcc gccttcaagc ctcggacagc 1231261 atcttcattg acacgcttat cacctttgga aagatatgta tccccctgtg tgtcacccgg 1231321 gcatccaatg gaaaacgtgc cgttcatgac gatgtgttgt tcgctgtttg ctgcatgaag 1231381 gtaaatggct tttgcagcat cgaatacatg atcaatcgat ccgcgtaaca ccgtgctgat 1231441 atggtcggtt ttcgtccaaa ccttggatgt atctgttttt ttcagcgcag acttgatcac 1231501 actgataaaa tcatccgtca tcggatataa agagaagcga aaaccggcga ttctgcttgt 1231561 accgcaaata tgctccattt ctccgacctc ctgttttttt ggtaaaataa aaaactgcat 1231621 atcctaaggg aatatgcagt catagatcga ttaagcgcac aaaaaaatac accattcggt 1231681 caacctgcac ttccccacgc tggtattatc cagatcgggt cataagggat caaagcgcgt 1231741 ttcttccgcg ctttatctca gccaaaacag cacccctagt gctttccgta tacaattttt 1231801 tattttgaca tcataataga tgataagaat cattttgtaa acaacgaaat catttttttc 1231861 atatagggac gggagaggat ggtcaaattt ggaaaaagga cacatattaa ttgtggaaga 1231921 tgaagaaaaa atcgccaggg ttcttcagct tgaattggaa tatgaaggat acagcgtcac 1231981 gatcaaacac aatggcacag aaggtcttga tgcggcagcg gaaggcgggt attccttggt 1232041 gcttcttgat gtcatgcttc cggggcttag cggactggaa gtgctgcgcc gcttgagaaa 1232101 aacggattcg cagacaccgg tcatattatt aacggcgcga gacagtattc ctgataaggt 1232161 aacaggtctg gacatcggtg caaatgacta tgtcaccaag ccgtttgaaa tcgaggaatt 1232221 gcttgcgaga atcagggcgg cgctgcggca aaatggaaca aaaactgaag atatcggcac 1232281 ctttcttaca tatgacgatt tgcgggtgaa cgaaaaaacc cgtgaagtga gacgcggaga 1232341 caaagaggtg gaattaacgc cgcgggaatt tgatctgctc gtctatatgc taaagcatcc 1232401 gcagcaagtg ctgacacggg agcaaattct aagctcagta tggggatttg attatatcgg 1232461 tgatacaaat gtcgtggacg tctacataag atacatcaga aaaaaactgg actatcctta 1232521 cgaaaaacag ctgatccata cgattcgcgg ggtcggctat gccattaagg ggtaaacgat 1232581 gaagctgaag accaagattc atctatacac ttcgatatca ctgttgattt tattaatttt 1232641 ggttcatacc gcagtatatc tcattttttc gtctgcgctg acatcaaagg atgcggcccg 1232701 gcttgctgat gagacggata acattgccga agcgctgcgt gccgctgaaa cagaaggagt 1232761 ggctttgcag gatatgctgc aggcctatct tccggcaaat ggcatggtgc gtgtagtgaa 1232821 tggtgatcaa aaagccgtta tgacgatcac aaaagaaaaa gcctataaag attttcctct 1232881 ctcttttcat agcggcgaaa cggcagatgt gaggaaacct gacggcaagc tgtttgccga 1232941 ggctgctgtt ccggtgattt ggaccgatgg acaagtcgtg tctcttcagc tggttgaaag 1233001 actggagaac acagaagaga gtctgtttct gctgaaaatc atcttaatcg ctgcaagtgc 1233061 tgctgtctgc attgcttctt tttttgcagg cagcttgcta gcccgccgaa tcatcaatcc 1233121 gatcagacga ttaatgatca caatgaaaga catacagcga gacaaagaat ttaaaacgat 1233181 ttctttagaa ggacagtcca acgatgaatt gtatcaaatg gggctgacat ttaatgaaat 1233241 ggcaatgatg ctgaaggagc actatgataa acagcagcaa tttgttcaag atgcttcaca 1233301 cgaattgaaa accccgctca ctattataga aagctacagc agcctgatga agcggtgggg 1233361 tgcaaaaaag ccggaggtgc ttgaggagtc gatagaagcc attcactcag aagcggtgca 1233421 tatgaaaaaa ctgaccaatc agcttttggc gctggccaaa agccatcaag gactcgaggt 1233481 tgatctgaaa acaatcgatc tgattaaagc ggcgcgcgcg gttatgcaaa cgctccagtc 1233541 cgtttatcag cgtgacatat tgcttgaaac agataaagag agcctgcttg taaaggcaga 1233601 tgaagaacgc atcaagcagc tgttgaccat tttgcttgat aatgcaataa agtatagtga 1233661 aaagcctatt gagatgtcag ccggaacgag gaatggacgg ccatttctat cagtgaggga 1233721 tgaaggcatc ggaatacctg aggagcatat cccgcatttg ttcgaacggt tctaccgggc 1233781 agatgaggca cgaaacagaa aaacaggcgg aacaggttta ggcctttcca ttgccaagca 1233841 aatcgctgat gagcatggca ttgagctgtc tgtcaaaagc aagccgggac aaggaacagc 1233901 tgtcaccatg caattcagcg aacagaatgg gggaggccga tgactaaaac aataaaaaca 1233961 gtatcttttg ctgcagcagc cattttagtt gtcatcatct gtacgtttct catcattcgg 1234021 caaacccatg agaacgtatt gtcaaaggag actgtcgtaa aaaaagtcga agcctcttat 1234081 gaaggcaagg tcacgaaagc aacacaatca aaggataaaa aaacatatga tataaccctt 1234141 gaaaatccaa agggaactta ctttgtaaaa gcagacgcaa tatcggctga cattctttca 1234201 atgaatagag taaaagcagt gaatccatct gccatgacag aaaaagaagc cgagcatctc 1234261 gcgcttgagc gggtgccggg aacggtcaaa aaacaaacac ggcaaagtca agttgccact 1234321 tataccatac aaaaagaaga cgggaaaaca tacgaagtga aggtagacat gcaggcaaaa 1234381 acagtcttgt ctgccgatca aatcagcagc aaagatcaac aaaaaacgcc gattacgaaa 1234441 aaagaagcca aaacaattgc agagcgaaaa acgggcggaa cagcggatga cgcagatctc 1234501 gaagaaagtg agggcactct catctttgaa gtagacgttg atcttcctga taataaggaa 1234561 gcgacagtga aaatcaatgc ctacacagga aaggtagcta acattgtgta tgaagactga 1234621 cggtttctca tcaaattctc atcttgctct cgttttcctt tcatgttgag tatgtaaact 1234681 gtactcatac aaaacaaagg agggctcaca aatgctcaag aaaaaatgga tggtcggtct 1234741 tttagcaggg tgcctagcgg ccggaggatt cagctacaac gcgtttgcca cagaaaacaa 1234801 tgaaaacaga caggcttctt ctaagacgga tgcactcact gaacaagaag cagaagcaat 1234861 tgctaaaaca gttgttgacg gcacagtaga agacattgac agagaccttt acaacggcaa 1234921 agaagtctat gaagtggaga ttgaaaaaga aggtgaagac tacgacgttt atgtagatat 1234981 tcatacaaaa caagcgctta atgacccgtt aaaggagaaa gcagaacaag tcgccataac 1235041 caaagaagaa gctgaagaaa ttgctttaaa gcaaacaggt ggaaccgtaa cagaaagtaa 1235101 gcttgacgaa gatgacggtg cttacatcta tgaaatggaa atccaaacga agcaaggaac 1235161 tgagacagaa tttgaaattt ccgcaaaaga tggacgcatt atcaaacagg agatagatga 1235221 ctaatcaaaa cccccgctgc agcgggggtt tttcatgata agaaaccttc ttttggacaa 1235281 tctaagtaga aaaggaggcg aaacgcatgg aaaagaaaga ggagcaatac atcaatcagg 1235341 ctgaatatgt ccctcatccg acgaaggaag gagagtatgc cttatttctt catgaaacgt 1235401 atcatttgct ttctgaagat gacgagacac aaacaacaga ataagggctt aggcccttgt 1235461 tttgttccgt aattgtgatg taagcgcatt tattactttt ttgagttgac atagcttgtt 1235521 tttttctgta atctcagtgt gtcaattcaa ttaggaactt cgttaggtga ggctcctgta 1235581 tggagatacg ctgctgccca aaaatgtcca aagacgccaa tgggtcaaca gaaatcatcg 1235641 acataaggtg atttttaatg cagctggatg cttgtcctat gccatacagt gctaaagctc 1235701 tacgattgaa ggcgcccgca cgcttttttt gccgtgcttc tttcaccttc aatcccgaag 1235761 gcttttttta tgcctttaaa acgaaaccaa tcaaaggagg tgcggagtat ggattctccc 1235821 cattcgagtc aatctgaaga agtacccata tactatgaca gcaagacaat tgattacacg 1235881 atgaggagac gaactgccgc accttctggc gaggccggca cgtctccgta gaggaggtac 1235941 gagtcccgat ggttcaaaac atgacctatg acgaactcat tttacgcatc attattttac 1236001 tgcgagacgg gaaaatcagg gattttagaa gtgttattga tgagcttcag ccctatgaca 1236061 tggcatttat ttttaaagaa atgccggaaa aacatcgcgc ccgctattta tcttatttaa 1236121 ctgtagacga tatcactgat atgatcgggg agctggaacg cgaatttcag cttgtcgtct 1236181 taaataaagt cggaaaaaca aaagcaacac tggcgatgaa caaaatggac aacgatgacc 1236241 tcgctcaatt gcttgaagaa atggacgaag aactgaagga acagctttta tccagcatgg 1236301 aagcgtcaga atcaaaagct gtacagctct tgatgaatta cccggctgat tcagcgggac 1236361 gcatgatgac aaaccggtat gtgtggatcc ctcagcatta cacggtaaaa gacgcggtcg 1236421 tcaaactgaa aagcttcgct gaaatagctg aatcgatcaa ctacttatat gttattaatg 1236481 aaagcaaaca gctggttggg gttctttcct accgcgattt gattctgggt gaacctgaag 1236541 aaaaggtgca ggatttaatg tttacccgcg tcatatcagc agatgctctt caggaccagg 1236601 aagaagttgc ccgcctgata gaacgttacg attttttggc aataccggtt gtagaagaaa 1236661 acaacgtgct tgtcggcatt gtgacggttg atgatattat cgacgttgtt attcgggaag 1236721 ctgatgagga ttacgaaaaa tttgccgctt ccggtaaaga catcaccttt gacacaaaag 1236781 cttacgtggc ggcataccgg cgtctgccat ggctgatttt actcttattt atcggactga 1236841 tttcaggaag cattatcagc tattttgaag acgcgctgaa gcaggttgtc gcgcttgcgt 1236901 ttttcatgcc gatggtgtca gggatgacag gaaatacggg aacacaatct cttgcggttg 1236961 tcatcagagg tttgtctaaa gaagaaatga acaaaaaaac gattgtgcgc ctgatcttcc 1237021 gggagttcag aacaagcatt tttatcggag cggtttgttc tgtgctgatt gcgattgttt 1237081 ctatcatatg gcaggggaat gcgcttttgg gatttgttgt cgcctcttca ctgttcttaa 1237141 ccttaatcat cggcacgatg tcaggaacga ttatccctat tattttgcac aaactgaaag 1237201 tagacccggc gattgcttct ggaccgctga ttacaacgtt aaacgatatt ttatctttat 1237261 taatctactt tggcattgcc actgcattca ttcactcatt ataaacgtaa aaagtccgtc 1237321 tcaactgcga gccggacttt tattatttaa cggtttttgt accgaaagtg agcattaagc 1237381 tgcccctcca gcattttttt ccgcacttgc ggatcgtttt ttaacatctg ttcttttttg 1237441 cgcatatcct ttaaaatctc tgccgtctgt acgccgtctt cacgcttatt ggcgatatcc 1237501 atcagccgct ccacatcggc aaaggagtat tttcttgtcc cccttgaaga acgctgcggg 1237561 taaatgagct ttcgttcctc ataatacctg atctgtctta cggacaatcc tgtcaattca 1237621 ctcacaattc cgattgaaat cacttttttg tctttataag aatgatcttc tgtggtcatt 1237681 tttccacccc tggatgtctt ttgataatag tatataaaaa acaaagagaa aaaacctgac 1237741 gcttgtcata ttttctaaca tcaaatagaa gatttttgaa aaaatacgga agaaaaatta 1237801 acaagaataa tgcgtaacac ccaagcgcgt tttatccttt atgtaacgaa tcaaacgagg 1237861 aggaaggata atcatggagg aagaaaaagc agtctcactg gcaaaagaaa ttatagagtt 1237921 ggatatcaag cgtgatgaaa tgctggagac gtttatgcag cttgccggag aacaggcttt 1237981 tcaattatta agatcggttc aaaacggaca ataccgaaaa tcttcgtaaa cataaattct 1238041 ttacattaga ttcataccac gttcatttaa aaagagtatc ttttgtatag gatacctcaa 1238101 aatgaaggag gacgctatga gtaatttatt gaaatccgct ttagaaaaag aacgacgcca 1238161 ttattctgaa aaactctatc agataggggt ttataataaa gaggtcatga acaaaatgac 1238221 gatttctgag cttcggaaag aatacgctta tttctttcga agcattacaa atcataaaaa 1238281 ttatccttat acaagataat gtataaggat ttttttgctt ttagaaggaa tttctcgaat 1238341 tatagcgaat acgtatagta agggactgaa ctcttattat atgtaagggt tttcattatt 1238401 tttttataaa aatcctatat acgaggtaga tatgatgaga ttatcgttta acgaagaaga 1238461 agttgagcgt gcgatgaatt tgtacagagt ttttgcaagg gctttcaaaa gtgtgtccga 1238521 acatagtatc cgtgatagca aagagcacgg ttttaatccc actgaatttg ctgtactgga 1238581 actcctgtac acaagaggcc cgcaaaaatt acagcaaatt gggtcgagac ttctgcttgt 1238641 aagcggaaac gtcacatatg ttattgacaa actagaaaga aacgggtttt tagtaaggga 1238701 gcaggacccg aaagataaac gctctgttta cgcacattta actgacaagg gaaatgagta 1238761 tttggataaa atttatccga ttcatgcact gcgtattgcg agagcgtttt caggtctttc 1238821 gcctgatgaa caggaccagc tgatcgtcct gctcaagaaa gcaggcatac acagccagca 1238881 tttgctgttt cgttaactat tctacactct ctatttcagg agagtgtttt tttgtttcca 1238941 tatgattctt tttaaaacat ctttaatctt cctatcagac atttcgccaa ggtatccatt 1239001 gacgtgtttt ttatactcct tcatctgttc gttcgattga aaaaatgccg cgatatactc 1239061 ttctgctttc tgcatgtccc agtttctcat atctgtgacg agtttccttt catgtagaag 1239121 gtttaaattc atttcctcct gtcccggcag tgcatgataa ataaataccg gaagccgttt 1239181 ctgtaagcat tcactgatgg tcacgcctcc gggtttagtc atgatgcctg tcgcctgttc 1239241 gtacaaacgg ttcatctctg ctttgctgtg aaggtaagga atcgcctcaa tcaaggggtg 1239301 gtgtaaactt ttgacatagg agtagagctt ttcgtttctg ccgcataata ttttgtataa 1239361 gatctttccg cctggcgaca gttcctgcac ccattttaaa atcccaccga cccccatact 1239421 gccccctgtg atgatgatgg tatatggcgg gtggtgctgc aaggtatctg ctgattccat 1239481 ttcaaaattt tggtgaactg gaatgccggt caagtatatg ttgttctgat cgataccctc 1239541 tgatattagc tgcttcttta cttccgtgct cggaacaaaa tggtaatcaa tgttcttccg 1239601 tccccataat tgattcacga aaaaatcagt gtatacattc acaaccgtca gattcggata 1239661 ttcaggcttt agtcggttca gcagataaga aggcagcgca tgtgtgcaga aggcgatatc 1239721 aggctgtttt tcttggagga tgtgcctcat ttgctgtgtg aacagccatt cgtacatgaa 1239781 atagcgtttg tcatgctgaa attctccgca ggcgaggagc ctgtaaatgc cgctgtacgt 1239841 tttcgggaaa tattgaatcc attttaaata agccacggag gacaattttt ctaaccgcct 1239901 atacgaatgt gaaaagatat caatcttttc agctgccagc ccttgagact ctaattcagc 1239961 ctgcaatgca tcagccacat gatgatggcc ggtggaaatg cttaaaaaag gaaaaatgag 1240021 aatgtttttc atgacagtcc tcctaaaaaa atatggcaac tatattttga ggagaacgtt 1240081 cacaaaatat aagggtgttt ttgatcataa ggaaggtgaa aagatgaaaa cttgtttcct 1240141 ttccatatgg agagtggttg atccgattta tttctttttt tcaaggctaa gcttgattga 1240201 caacgatcaa aaaagcgttt ttcgagtcag gctgacgaag tacaaaggac atcatgtcgt 1240261 gcttagcgac ggaacgcata taagaaaaaa tgatgtgctc gttaaaatcc acctgcataa 1240321 cataaagctg atcagggagc tgcaaagcat tgagagcgca gtcagaaagg gaatcattat 1240381 ttatcagaaa gtatatcaat cgatgccgct tcttcttgac tatatcaaca atcataaaaa 1240441 aagcgagaaa atcaaaggaa tcattgggat tacaatgctt gacaaaggtg tggaaaggct 1240501 cggctttgat gtgatcaccc cggtgaaccc tttttacaga tgctttaaaa aagtgtctca 1240561 tgtgccgatt ttatatttga cttcaaagcc tgtgagcttg cggcatttac cgaattcatc 1240621 ctatttgttt atctcaaaag aaaagctgca gaaaacctat caaaaaaaag actgatgcct 1240681 cggtcagcac agtctttttt gattaaatct gatgaaatgt cacttcaggg cggcttccga 1240741 cacggatatt tacgccggtt tgtcccaagc cctcgctgat ataaaatggt ttatcgtgat 1240801 gataatgaag gcctttaatc atgttcattc gcacgagctt tcccattttc accaaatgat 1240861 acggttttgg ccagtgaatt tgcccgccgt gaaaatgccc tgacagcagg taatcataat 1240921 gaacatcttt catatccaga ataatatttg ggtcatgtgt taagacaaga tgatagccat 1240981 tttccagact ttgataagag ccggtgatat tactccgatt cgtactgtaa tcatcaatgc 1241041 cgataatatt gactggtcct gcagccgtct cgattcgaac atgttcattt tgcagcgtga 1241101 tacagccgtt ttcctctaaa actcgcttca atctctgaaa gtcctcttct ttcaatacat 1241161 aatcgtggtt accgaacacc gcgtacattc catatgcagg ctttagcttt tgcaaggcgt 1241221 tcaagtaacc tgccagtttc ggaatattac gtttccgatc aagaaaatcc ccggtaagag 1241281 caatgatgtc cacaggctga tcttttgtta aatgatacag ctcctcaggt gagactgaaa 1241341 tgttttccaa gtgaagatca gataaatgaa ggatatttaa tttttttctg gctggaaggc 1241401 cgtctttttg gtcgattgaa atggtgttga ctttcacatc ttttgtattg cggttcgctt 1241461 tatatagaaa tggcacaaat acgagtatgg ccaatgaaag taagattgta aacaaaatat 1241521 atcccctccc ttctatcagt atagtaagtg atcaagccct atggatagcg ggaattaatg 1241581 ggtagagaca ggttgaaaaa cggattgtca tatgatgaat gatttggaag ggaaaaggga 1241641 taataaattt tgacacatga ggcagaacat gccgacggag tcagaataac aaatggatgt 1241701 gtaagcaatg ttacgattga tgagacaaca aaaaaaagaa acatattatc tctggatcgc 1241761 attatttctt cttttattgt atgtatcccc gctttttatt ttaaaggaag atgcccatat 1241821 ccgggtccac gataatttag attccaacat cgcttggtac aaggttctgg ccgatagcgg 1241881 agaaatcgtc ggcaaggttg acgctgccat tccgcaaatc attaacgggc tgccccggga 1241941 tgcctttggc accgagtgga gcggaattgt ttggctccat gctttctttt cttccatgac 1242001 cgcctatgca ataagccaga cggttacaag agttgtcgct ttttttggaa tgtatgtgct 1242061 gctgaagaaa catataatcc cggaaccaaa agcggctttc atccgaattg gcgtatcgct 1242121 tgcatttgcc ttaacaccgt tctggccttc gggaatgctg agtacgcttg ggtacccttt 1242181 ggcactgtgg gcttttttaa atatccgaaa aggggatatc tcatggagag agtggctgac 1242241 gctgggcttg ctccctctat actcaagctt tgttctaggc ttcttctttt tcctggcagg 1242301 gatggcgtgt ttttggctgt atgatgccat tacaaaaaga agatggaatt tgatgttctt 1242361 aggcagtatt gcatttatga cgagtatcta tcttttcgtt gaatatcggc ttgtctattc 1242421 gatgctgttt gagcacgcac cgatgcatcg tatcgaattt atctcatcta ggcatgacgt 1242481 ttggcattct cttcgactat ccataaaaaa ctttgtctat ggccataatc atgtgatgac 1242541 cgttcatacc gttgtcatcc ttccgatcct gatggtcgta tttgctgctc tgctgttcaa 1242601 acgaaatcgg acaaagccag aaaatgttta tctgttttta tgtgtgctta attacgggtt 1242661 gtcattatgg tatgcgtttt ggttcaacaa aatttgggct gttccaaagc agaaatttgc 1242721 ttttttagca gaatttaatt ttgcccgttt tcattttctt cggccgcttg ttatatacgt 1242781 gagctttgcg cttgctttat atctcatttg gcggatgggg aaaggatgga aatggcttgt 1242841 gtacgccgca gtcgctgcac agctgatggt gttggcgcct tttaatgaag aatatacgta 1242901 tggtgttcat tacaacgcgc cgacattcag ggagttttat gcatcagagc aattcaaaga 1242961 gattaaggaa tatatcggac gtccgcaaga ttcgtatagg gtggcgagca tcggactgca 1243021 tccgtctatc gcccaatata acgggtttta tacgttagat acgtataaca atctgtatcc 1243081 gctctcatat aaatatgaat ttagaaaaat catcgaaaaa gagctggaaa aaaattctcg 1243141 gctgaaacaa tactttgatg aatggggcag ccgctgctac ctttttgtcg atgaactcgg 1243201 taaacgatat gatttcaaaa agaactcgaa gaaaacgatc aacaaccttc aattaaatac 1243261 agatgtattt aaaaaaatgg gtggacggta cattttttct tcagttccga tcatgaatgc 1243321 tgaacaaaac catctcgcgc tcgtaaagac gtttgaccat aaagattccg cctggcgcat 1243381 ttatttatat gaaacaagat aaggaggata tcgattgaaa cagtcacagc cagtattaac 1243441 catcgtcgtc ccgtgtttca atgaagagga agtgtttcaa gaaacaagcc atcagctgac 1243501 agaggttgta gatgatttaa ttgaagaaaa attaattgct gaagacagta aaattctgtt 1243561 tgtcgatgat ggcagcaaag accgcacttg ggctttgatt gctatggaga gcataagaaa 1243621 caagaaggtt accggcttaa aattagcctg caatgtcggc caccaaaaag cgcttttagc 1243681 cggattgcat aaagcgaaga ataggtcaga ctgcgtcatt tcgatcgatg ctgatcttca 1243741 ggacgacatc tctgtgatcc gggattttat gctgaaatat catgagggct gcgagatcgt 1243801 ttacggtgta cgccggagca gaaaaaccga tacctttttc aagcgcacga ccgcgttagg 1243861 gttttatcgt ctcatgaata aacttgggat taaattaatt tataatcatg ctgattttcg 1243921 tttaatgaat aaaaggtccc ttgaagagct tgagcgttat ccggaagcga atctgttttt 1243981 aagaggtatt gtccccatga tcggctttaa atcggccgaa gttttgtatg accgcaagga 1244041 acgctttgcc ggcaaaacga aatatccgct gaaaaagatg ctatccttcg cttttaacgg 1244101 gattacttca ttcagtgtcg caccaattcg attctttacg cttttagggt ttgttttgtt 1244161 tttcctcagc gctgtggcag ggattggcgc gtttattcaa aagctgctcg gccatacgaa 1244221 tgcaggctgg gcgtctctta tcatatccat ttggtttttg ggcgggctgc aattgatggg 1244281 aattggaatc atcggagagt atattggaac gattttttct gaagtgaaaa gacggccgaa 1244341 atacgcgatt gatattgatt tgtataatga acagctgagc ccgcttcagc gccaggaaaa 1244401 agagcggtta gaaaaaaagt acagttaaac acggaaagag ctgacttcat tagtcagctc 1244461 tttttcttca actgatgcaa tatagcgcta agcggttcgt cttgcgggtt gcggtaaaaa 1244521 tcaaaaaatg ggcagccctg cttcttaatt cgatcgatga ccgtatcaat tgtaaacaga 1244581 gcgggtgtta aagatgattg cacctcatgc cagtagagcg gggctgcaac agtcccaagc 1244641 tcatttcctc tcgttgaata gggacagata atcgtttttc cttctgcatg ctgcaaataa 1244701 tcaagataca atttgcagtg tctgttttta atcaagcgtt cagtggtaaa gagctcggga 1244761 aatgcattgg tgcagtactc tgcgatcagc tgcgtaaatt ggcgtgtttc ttcatacgta 1244821 aatgcctcgg gagacaaggg aatataaagc tggatgcctt tgttgccgga cagcttcggg 1244881 tacgatgtga tgccaaagga atccaacagc cgcttcagtt catttgcggc ctgcacggcc 1244941 ataagaaagt catctcgcga aggcgggtct aaatcaatga caatctcagc cggacgcctg 1245001 cttttaatgg tttgaaaagg aacgtgaaac tccaaagcaa gctggttgca aagccatagc 1245061 aatgtagaca tatcctcaca gacaatatgt tcatggcttc catcatagaa agactgaaca 1245121 aaatccggcg catagtccgg cttgtttttt tggaaaaatg attcgctcct agatccatgc 1245181 ggatagcgga tgacggtgac agcccggttt ttcagaaatg ggagcaggta gtcactgact 1245241 tcaatcatat actgaataaa atcttctttt gtttttttat tcttttcaaa tatgatttta 1245301 tccaggcttg tgaactggag ctttgggtga accggtttgg agtgtcgtat gacttgcgca 1245361 tacgtgcatt cggtccagtc catttggaat tcgaaaccga taaacgatac ctctcttaat 1245421 gtgccttgga gaattgttaa gtattgaaca gctgcacaaa tcgaaggttc aagcgtaaat 1245481 tcgcctgagg gtgtttgatg tccgtgctgt tccataatct cgcgtatagc gcttttttcc 1245541 tcatcacgca ttccgtgcga gacagaggca atcggtgtca ttattccgtt ttttaacacc 1245601 gataccgtca gaaacccgtt gttagggttg aaccctgtta tgcaaacata agcttgttta 1245661 aagtttttat atttgagcca atcggacgac cgcttctttt caagccattt gctgtttgtt 1245721 ttcttcgcta caattccttc tccgtcatat tttattacca tctcccagag ttgatcaaaa 1245781 tgatcataac agggaatgga ttgaatggtt tcttttgcgt aaggatctgg agatgcagga 1245841 agctttgctg cggatatgag ttcacgcagc gattttttgc ggtccaaata cgaaagaagc 1245901 gttacatctt ctccgcttcg ctctaacaaa tcaaaggcga gaaagcagca cggccgcgcg 1245961 tttgccgatt cctgaatctt gtctggcctt ttcaaacgcc cccgcacttg aaggtgttca 1246021 aaatctgcac gacagggatt caccaaacat acgatttcac cgtcaagtgt cagcggaagc 1246081 tctttttcta ggtgctgaaa ggcagttttg gcgaattgtg tgatttcagg gaaggtgctg 1246141 ctgagctcca caccatttct gctggttaag gtcacacctg aagaatggat gcggagaata 1246201 cagcggtacc catcatattt tacttcgtaa cgccattctg ctccgattgg cggtgacgaa 1246261 gttaagaccg gctgcatggt aaacgccatg cgctatgatg tgccggaggc tttttttcta 1246321 gttgtttttt gttttttatc tccggctcct ttcggttcag cggcttgtgc aggtgcggca 1246381 gccggtgtct cccggttcgg ccttctggtt ctgtcgatgc tggcttgcag agcgcttacc 1246441 aggtcaatga catcttcacg aggtggcgct ttatcaggag tgacagccgt ttctttattt 1246501 tctagcttgt cgttgactct ttgcagcagc gcctgtcggt acgtgtcttc atatttctca 1246561 ggctcaaact tagcagtcag ttcatctatt aatgtgatag cagtttgcag ttccttatcg 1246621 tttacattcg attgatcagg tacacctggg acttgagcgg cgcttctgac ctcatcggga 1246681 taatggatag actccatgac gatacaattt tcataaacgc ggagaatcgc cagctgctgc 1246741 tttgacctga ttgtcatatt ggcgataccg atctttccgg ttgagcgcag cgcctcacgc 1246801 agcagggtat aggccttcgt cccattatcc ccggggccga caaagtagga gcggttaaaa 1246861 taaatcggat caatttcctg aagctgaaca aagtcaacaa tctcaactgc tttctcctca 1246921 tgctcctgtt ttaagctttt taaatcttcg tctgtcagca ctacatattt tccttttaca 1246981 tattcatatc ccttcacaat ttcatcagga ctaagagttt tttcgcaatt tgtgcaaact 1247041 ttctcgtatt tgattggtgc gtgatcctct ttatggaggc tgcgcagttt aatatcttta 1247101 tcttctgtgg ccgcatatag cttgatgggg atgtttacta atccgaagct gatcgatccc 1247161 ttccacattg tatgcatatc gataaacccc tttttttctt tagtgtgaag agaaggagta 1247221 cgattcatgt gtagtaactt atgggtgaaa aaaagccggc gctgttattg cgacggctgt 1247281 tcaataatga attgttcgaa ttgttccgga ggtattggcc tgctgaaaaa gaagccctgc 1247341 aaatggtcgc agcctttttc aaaaagaagc tgcttttgag ctgcattttc cacaccttcg 1247401 gcaatcacct gcaaagacag ctgatgcccc atggcaataa tagctccggt aatttgctct 1247461 gatttaggat gggtctgaat atcgtcaata aatgatttgt caatcttcag cctgtgaatc 1247521 gggaagtcct tcaaatagct aagagagctg tgaccagtac cgaaatcgtc aatactgatt 1247581 ctgattccta attctgttag ggatgacaaa acctttttgg agtgattgag attgtccatt 1247641 gtcatgcttt ccgtcacctc cacttcaaga agctgcggag gaagctggta cttattaagc 1247701 gtatccttga tgaggggaat cagatcttta gattgaaact gtctggcgga aatattaatg 1247761 gcgacagaaa gatcatagcc tttgtcatgc caaatccttg cctgcttgca tgcttcatct 1247821 ataatccact ttccgatatc aataataagt cccgtttctt ctgcaacacc gatgaattct 1247881 ccgggcggac gcagttgccc gtctggtgtc acaaggcgta tcagtgcttc tgctcctgtc 1247941 attttttgtt ttttcacact gaattgcggc tgataatgca agacaaatct atcgttttcg 1248001 attgcttctc tgagtaccat ctcttggtta agcttaacgg tttctttgtt gccgattgaa 1248061 aaagaatagt atctgtattt gcttttgttt cgttctttag ccgcatacat cgccatatca 1248121 gcctttttca tcaattcaag gccatccgtc ccgtcttttg gagatatcgc aatcccgata 1248181 ctgacagatg tgacaagggt gtgatcttga attttgaaag gttttttgaa tttttggata 1248241 atttttcttg ctaaaacatc tgcttcgcct gttcctgtat tggcgtctgt taatataata 1248301 ataaattcat caccgccaag acgggcgata aatccgttat cagggactac agatgacagg 1248361 cgtttagctg caaactgaag caattgatca ccgacattat gccctaatgc atcgttaatc 1248421 actttaaacc ggtttaagtc aagaaagaat acaacagtgt tataatgcaa ggaatgctcg 1248481 cgattcagca cctttgttag atgagagatg gcatgccttc tgttaggtaa gtctgtaagc 1248541 gaatcataat gagccattct atggatttct ttttctgctt tgtactgctt cgtcatgtct 1248601 ttacaaatga cataaatgct gtctagttcc tgattgacct caacaggtat aagcgtaata 1248661 tttaagtgaa actggccttt ttcagtgata agatcgctat cgctgttcat cgcttgttta 1248721 tcttttttaa cttgctcaaa aaggcgctta accttcagtg atgtgtaatt cctccagtca 1248781 tgcatgctga agccaaattt gctgatcatt tcctcaccag cgtgattgga agatattatg 1248841 tctccttcta atgataaaat aaaaattgca tcaatattgt ggacgattaa agactgaaat 1248901 cgctgttcgt tatcctttat gcgttcgctc tgtttaataa actttcgatc tgcatgggaa 1248961 ctgaataaca ataacgtttg gatacaaaaa ataattaaag taacaaaaat tgaccaatga 1249021 aacgtttgca cctccatatg gcttccgggc ggagccatgt ccttatggaa agttgccgca 1249081 agcatccctg tgtagtgcat gcccgaaatc ccaatgccca ttacaattga actgacgcct 1249141 ttatagaata taagatgctc agaatgtttt tttacggcca agtcaaagaa tatttttaac 1249201 gagacgaaag aggctgcaat cgcaatgata attgaaactg taaataaaat aggttcgtaa 1249261 ataatcatta cccgggaaat ggcagacatt ccgatatagt gcatagaagc aatagatgcg 1249321 ccaagcacaa ctgatccggt aagcagtctg taatatgtaa gaatgtgccg gctgacaaaa 1249381 tataatgaca caaatgatcc cgaaacagat gcgccaatgg ctgccattaa aggcatgaat 1249441 tcatattcca tcggcatttc catatggacg gccatcatcc ctacaaaatg cattgaccaa 1249501 ataccgaatc ccataataag tgagccgccg atcagccaaa ttttactttt taagcctgta 1249561 ttgatggtga ctttccttga aagttcaagg gaaatatacg aggcggtaca ggcaattaga 1249621 atagataaac atatgagagt cgtattatat gtaacgtgta tttccaaatg gagattcccc 1249681 ccgtatcgtg tgttccagtc ttgttgactc tctttattat cggctgctta accgcagagt 1249741 ttcagccttc aaaacgatag aaatacgagg gagatctatt tttagttcaa ctgaccgtga 1249801 aaaatgtgtt aaaatcatct tgatgttttc cgaaaagaga aaaatgtatg atacataaac 1249861 atgaaacaag ggagttggtg gctatcgaag agctggttat gtcatggatt gaagcattta 1249921 aaagcttatc ttattttgga atatttctag cgctcagcat tgagtttatt ccggccgaag 1249981 tcgtcttgcc gcttgcgggc tattgggtat ctaaaggcga tatgacactt gctggcgttg 1250041 ttttggcagg atcgcttgga ggagtggccg gtccgcttac gctgtattgg ataggccggt 1250101 acggaggaag gccgtttctt gaacgttttg ggaagtatct ctttattaaa cctgaagcgc 1250161 ttgataagtc agataatttt ttcaaaaaac atgggggctt tgtcgccttc agcggccgtt 1250221 tcttgcctgg tatcaggaca ttgatttcca taccgtgcgg aattgcaaaa atgaatgttt 1250281 gggtgttttc gctttataca ttcattgcta tgcttccgat tacatttgta tatgtttatc 1250341 tcggtgtgaa gctcggtgaa aattggaagg cagtcggctc tattcttgat caatatatgc 1250401 ttccgatcgg gatagcgatt ttggcgctgt tcctgctcta cttactgatg aaaaagagga 1250461 agaaacgcac gcactccgaa caattatctg tatttttgaa aaataaacgt tgacaaatca 1250521 ctgcgctgcg catattattg acgtataaaa tcatatttct tgaaatccca aaggggagta 1250581 gcgtccggaa tgtattccgg aaacaaagtc gtcatttcat ggattgtatc catcggcttt 1250641 gttggcatgc ctgaattcat gtctagcaag acctttgcct tatgtcggca aaggtctttt 1250701 ttgcatggtc cggccggcat aagatcggat gaagagaaag aaaacaactt ttttgggagg 1250761 gtatcattta tggatgcagc attattatta gagtatggtt gggttcttct cgtcttgatc 1250821 gggctggaag ggattttagc cgccgataac gcgctggtta tggcggtaat ggtaaaacat 1250881 ttgccggagg aaaaaagaaa aaaagcgtta ttttatggat tggcaggggc ttttgttctg 1250941 cgatttggct ctttatttgc aatttctttc ttggtcaacg tatggcaggt tcaagcgatt 1251001 ggcgcgatct atttgctgta tatctcagca agccacttat tgaaaagata tgtatttaag 1251061 aaagaagaca cacataaaga gacgaagcaa agcggttttt ggccgactgt tttaaaagtt 1251121 gaactggcag atatcgcgtt tgctgttgat tccatcttag cagcagtagc gctggcggtt 1251181 acacttcctg ggacatcact cccgaagatc ggcggacttg acggaggaca atttctcgtc 1251241 attttggccg gcggtatcat cggactggtg atcatgcggt ttgcggcttc catgtttgtg 1251301 aagttattaa aggaacgtcc aagcctagaa acagcagcct ttgtgattgt cggctgggtc 1251361 ggagtgaagc ttgctttata tacgcttgcc catcgcgaca tagcggttgt ttctgagcac 1251421 tttatccatt ctggaacatg gaagctgata ttctggggtg tcttagcagc aatcgcggtt 1251481 tgcggctggt ttatgtcagg tgggaaaaaa cagccggagg gtgcacaaaa cgaacaaaaa 1251541 aacagcaccc gtgaacgggc gtaatctgaa agactctgct taaaagcaga gtctttttgt 1251601 gtttgaagcg ttttcataag cgaaataaaa taacattttt ataacatctt tgttacaaaa 1251661 aacacgcata aaaccccctt aattctttag aaaggcacga aatcatgtat agaacgtcag 1251721 aatggtttgt cataattgag acattggaaa tcaatatttc tttttctcct ttgcgaatcc 1251781 ctatcaaatt agctatcatt aatgagtagt tatagggagg aactgaggtg aaaccagtgc 1251841 ttagcctttt gtttaaattg ggaaaaaaga agcaaacact tgaaaaagct gttgagagta 1251901 tacaaaaagg caataaagat ctgcaaaatg aattaataca gcaatataag ccatttatcg 1251961 caaagacggt ttcatccgtt tgtaaacgat atatagatga aaaagacgat gagttcagta 1252021 ttggactgat cgcgtttaat gaagctatag aaaaatattc acctgaaaaa ggaaattctc 1252081 tgctcgcatt tgctgagctt attataaaaa gaaaagtcat tgattacatt agaaaagaag 1252141 ccagaagcgc acaaaatata aatatcgatt tacaggaagg agacgatcag gagtcatcac 1252201 aaagcctgat tgaagccgag ctttccattg atgaataccg ccgtcagatt gaacaggagc 1252261 agaggcggga ggaaatcctc tattttcaaa agcagctcaa ggattatggt ttatcgttta 1252321 aagaactgct tgaaaattct ccaaaacaca cggatgcaag gcaaaacgcc ataaaggtgg 1252381 caatgacgct tgttgaacat gaagaattgg ccgctatcct gtatacaaag aagcagcttc 1252441 cggtcaaaca gcttgaacag cttgtctctg taagccgaaa aacgattgag agaaacagaa 1252501 aatatattat tgcgatgtgt attatcatta cgggtgatta tatttattta aaagattatc 1252561 ttaaaggggt gctgcactca tgagaagagg gattatagta gagaaaaata aaaaattcgt 1252621 cacgttgctg acccctgacg gacaattttt aaaagccaaa aatgatcgac acagctatga 1252681 aatcggagaa gaaatcatgc ttccgagtga aacacgcatg ggcagaaggg ccagcttttt 1252741 tgattttttt aaactgcgcc ctttcaaaat ggggattttt acgatgactg ctattatgct 1252801 ctttattttt atagttctcc ccgttttttc taataataag gcctatgcgt atatgacaat 1252861 cgatatcaat ccaagcgtcg aaatggcgtt aaacagcgat tatgaagtga ttgaactgac 1252921 gcctctaaac gatgagggac agaaagtcgt gaatgatata gatgattggg agaagactga 1252981 ttttaaaaag gtgattgacg atattataac cgactgcagt gaacacgggt atgtaaaaaa 1253041 atcgaaagaa atattgattt ccactgttta tgaaaacaca gaagacaata catataaaaa 1253101 ggctgtgaaa aaacagctga atgatgtgac tgaaaaatat aaaacgacat accgcatgga 1253161 atctctcgag tcagatatgc aaacgaggga aaaagcgaag aaagaaggcg tctcaacagg 1253221 cagctacatc aaatcaaatg aaaagaatga caataaagat ataaaagatg actccagcaa 1253281 accatccggg gaagaggatc aaaagagtga tgaaaatgag gatgaaaaca ccgatcaaac 1253341 tgacacccag gacagcaagc aaggagataa tgaacagctg aatgatgcgg attccggaga 1253401 ccagaaagaa gagaaagcgg atgaccagat tgatgatagt gacaaagata aaaaaataaa 1253461 ggaatcagat gaaaacacaa ataccgaaaa agatggggac catgagcaaa ccccaataca 1253521 agatcctcaa gataaaggaa atgaaaataa cggcgctgac aagggccaaa gccaatatca 1253581 cagggactgg aacaatggtg aacaaggcaa gaaccgttct tcgtccagaa gggataacgc 1253641 ttcagaccga cgtaatccaa acggctacag cagtgataat cattcagcta aaaatgaaga 1253701 ttcgccgagt gcccccggcg aataaagacc tgaatttatt tagttgtgcc atttaattgt 1253761 gattgtgctt gctgtaccag ccgctttgtc atttctccgc ctacagagcc gttagcgcgt 1253821 gcgactgtat cagaaccaag gttcacaccg aattcttgag ccacttcgag tttaaattgg 1253881 tctagtgcct gctccacccc tggaacaacg agtttatttc tgctcgccat ctttttcatc 1253941 tcctttttcg ataaagaaat tcttaacgcg tatttagttt gaaatatacg gggtttattt 1254001 atgctggcaa ttgttgtgga gaaaaataaa accccggcct ctgagccggg gtggcgcaga 1254061 ctatagaatg tctgctgtca ttttatgtgc ggttgcctga atatggaatg tcaaaatgga 1254121 gaggactgta atggcgataa tctgtctgat tttaagccat tggctgtcat tcagttcttc 1254181 aaaacggtga cggagacgct ctgtctcctg ttcggcgatc tcctgcagat ttgattcttt 1254241 catagaagga gtatcttggt gatggatggc atcaagcaca tatgcgcagc tttcataata 1254301 agcaatcggg ctgatgacat catcagatct gtctgagatt gtgttaaagg ccacttttaa 1254361 aatagcccgt atgtgttcaa agtcataaat ggattttaaa tcacgtacaa ttaaaagaat 1254421 aactgcctgt tcaattgagt attttttgcc cagctcaggg tgtccgatca gatctttgat 1254481 atcacgcttt acccagtttt gaatcgcggt tgactttaac gaagtcagct cgcataagtt 1254541 gccaagctct acgatttcat ttgtagacag accgtattct tttttctgtt tttttcgttc 1254601 gtatcttgta agaaattcag gaatttctag atgattggct gctttttctg ctgacatgtt 1254661 cgctgattgg acgagaatgt cgagcgggct atgttctcct tgtcctttta gggaatagag 1254721 cagccgcacc atatcggttc gagagagttt aaaaatgttc attgttcacc tctttaaaca 1254781 atttgacgcg gatataggtc tatgtataag ttcaaaattc aagcgtcagc aaattacatt 1254841 aacatcatac gtcgaattcc ttgcattttc aaatggatgt tttataattt aaatatacgg 1254901 gttcttttga acttaaaata acggaggttg ttatggcgaa aagaattttt ctgtttattc 1254961 taacgaatat tttggtgctt acaacaatcg ggatcgtttt gtctgtttta agctctgtta 1255021 caggagtcgg gacgtacttt acagctgatg gcggtatcga tccaatggcg cttcttgtgt 1255081 tcagtttagt cgttggattt gtcggttcct ttacgtctct tgcgatatcc agatggatgg 1255141 caaagacgat gatgggcgtc agagtgctga atccgaaaaa acactcgctc agctatgagg 1255201 aacagcaatt ggttgatcgt gttcacagat taagccgctc tgccggttta acgaaaatgc 1255261 cggaagtcgg gatttaccgt tcacctgaag taaacgcgtt tgcgactgga ccgtcaaaac 1255321 gccgttcact tgtcgcagta tcgtcagggc tgctggagca gatggatgac gcagcagttg 1255381 aaggtgtgct tgcccacgag gtcgcgcata tcacaaatgg tgatatggta acaatgacgc 1255441 ttttacaagg tatcgttaat acctttgtcg tctttttatc gcgtatcgcc gcttggatag 1255501 caagccgttt tgtcaaagaa gatctagcgc cgatcgttca ttttattgca atgattattt 1255561 ttcagattgt cttttcgata cttggcagcc tggttgtgtt tgcgtattca cgccatcgtg 1255621 aattccatgc tgacagggga ggagcggatc ttgccggcaa ggacaagatg attcatgcgc 1255681 tgcggacgct taaaagctat tcttcccgga ttttggaaga cgatcagaca gctgtccaaa 1255741 cgttaaagat taatggcaag aagcgctctt cacttttctc tactcatcct gatttagatg 1255801 agcgaatcag acggctggaa gctaaataat acaaacacat tgttcctctg agagaattct 1255861 cagaggtttt ttattttatc cattgactaa aatcataaaa aaataagcaa gttaagaaaa 1255921 tgtttcgtaa aagcctttaa aaatggacct aatatcttta gaataattac cgtacttaaa 1255981 aagagaggca gaaggatttt acatgagatt aaagtttgga aaattgatac aggccttgtc 1256041 accggcccag ctgatcgcat tatattattt tcttgcagtt actgtggccg ttatattgct 1256101 gagtttgccg gcggcccata aaccgggggc ggattggacg tttattgatg cgctttttac 1256161 agctgtcagt tcagtcagtg taacggggct gacagttgtt gatacagctg atacattcag 1256221 cacaataggg atttttatat tagcatttgt tctgcaattt ggcggaatcg gaattatgac 1256281 gctcggaacg ttcatttggc tgatcatggg aaaacgaatc gggctgaaag aacggaagct 1256341 gattatggtt gatcaaaacc aatcccagtt ttcaggaatt gtcaatctga tgaagcaggt 1256401 actgtttctg atcttgtgga ttgaattttt tggcgggctg atactcggca catatttctt 1256461 aacctactat gactcctatc aggaagccta tttacacgga ttttttgcca gtatcagtgc 1256521 aacgacaaac ggcggatttg atattaccgg taattcgatg attccatttc gccacgatta 1256581 ctttgtgcag tttattacaa tgcttttaat tatatttgga gcgattggat ttcccgtgct 1256641 tgttgaagta aaggatttcc tgttttcaaa gcatcggcgt tatccattta cgctttttac 1256701 aaagatcacg acgattacgt tcggctcact tgtcttgttt ggagccattg gcatctttgc 1256761 cctggaagca aaccatgcgt tcgcaggaaa atcatggcat gatattttgt ttttgtccct 1256821 gtttcaatca acggcaaccc gaagcggggg gctggcaaca atcgatatca gccaattatc 1256881 agattccaca ctctttttta tttgtgcgct gatgtttatt ggagcgtcgc caagctcagt 1256941 cgggggaggc ataaggacaa cgacttttgc tttgaacctt cttgcgctgt ttcattttgc 1257001 ccgcggcaat aaggccgtaa aggtattcaa acgggagctt caccctgctg acttgatgaa 1257061 gtcgcttgtt gtcacgatga tggcgatcct gctcgttttt ggcgcgacac tcattctgac 1257121 cattacagaa aaacattccc tgctggagct tttgtttgaa gtgtgctcgg cattcggtac 1257181 aaccggccta tcgcttggaa ttacggcaga tttgagcagt gttggaaaat gcgtcattat 1257241 gattgtcatg tttatcgggc gaatcggcat cttgaccttc ctgtatctga tcggaagaaa 1257301 ggaaattgaa gcgaattatc actatccgaa ggaaagagtg attatcggat aggcaaaaca 1257361 ccgcatattt tgcggtgttt tttgattacc aaaaaaaaga tgtgtgcctc ctgttcagtt 1257421 ggagaaccta actccgacag gtgcaattta cgctcctgca tcttaaaatg tctgaaaatt 1257481 ggcgaggagg attcgtatga agcgtaaagc tgaagtgaat gaagccatta aaaataacaa 1257541 tacacctacc gagagcatgg accccaattc atataagaca caatatcatg acgaccccaa 1257601 ttttagaggg gcaaaccgca attccaaaca gggccagcag ggaggcatgt aattgtgaag 1257661 aaaaaccgtc atagcagaga catgcaaaat cataaaaagc ctatgaataa aaaggtgctg 1257721 gaggaagaat tctcaagtga actcggggat tacaatgccg gaaagatcat cgaaacgctg 1257781 gaagtcacca agcctgaaaa gaaaaaagaa aaaaacaaaa aacaacaata aaaaagacct 1257841 cttaggcggc gtcccgctta agaggtgctt tttctatttt aaataagcat ttttgcccgt 1257901 tcctctgaca aattgcaata agcttgtcat cctcagctca atgaatggct gagcgactgt 1257961 cttaacaaag ttgctggaga ggactgatgt cagggctgct gttaaaagca agaggatcac 1258021 taagctttga tagtcagtaa gccaatcctc aagcccgacc tgccgtaatg tcttaataat 1258081 aaacccgtga agcagataca cgtaaaatgt ccgggttccc catttggtaa agaaataccg 1258141 tttttgcgga acgagcgcta aaaagctgaa ggttgcccca aaggcgagta cataccagcc 1258201 gattcgggat agtccgctta ccagggtaac gtctccaaat gaagaatacg gttttgaacc 1258261 aaacagaaaa gaatagtcaa aatcgatgcc ccagcagatg acgaatactg cggcaagcac 1258321 tccgagcgca atttgtttgc cgcgttttga tctcaataaa tcaaaatgat gtttatttaa 1258381 ataaaaaccg acaaggaaca tcggtaagaa tacgaatgtc cgtgacaagc tcagcgtgct 1258441 gctgacaaag tccagataac cgatcagcac ggcgattccg cagctgacaa acagcgccca 1258501 ctgctttgaa agctttgaaa aaggatatag gagcaggttc caaaagaata agcttacaag 1258561 aaaccataac gaccattgcg gatcaatcgg gttcacattt gccatgcttt catcttgcat 1258621 aatgtaataa aagacggaat aaataatttg gaaaatcaaa tacggaataa tcagcttgac 1258681 cgccagcttt tttacatatc ccgcccgttt aaagcctttc gcgaaataac cggatacaag 1258741 aataaatgca ggcatatgga atgtgtaaat gaacttgtag aggtagagca taaaatgatt 1258801 atcattaata aaggaacgaa ggatatgacc gaatacaaca aggaatatca ataaaaattt 1258861 tgcgttatcg aaataactgt cccgcgattt actcatagca tcaccttctc tttcatcagt 1258921 cactaagaga ttattccctg ctggtacata ttttaaaata aaagatgaaa aaggaatcta 1258981 aaaaaatgct gattgttagg tcgatgtaaa gtgacggtaa ggatcgtaga aaatgtcttc 1259041 gtaatgtaat gacgctgaaa ttttctgaaa tttatagggc aaatgaagga agttcccgca 1259101 ttttgtagaa atattgaggg ataggttttg aagaaggagt gtacatgcat ggaaactctt 1259161 ggtgtccaga caaactcgga gctgcgagag gaactgaatc gcctcaaaga agaaaacgcg 1259221 cgactgaaaa aggaattgaa tcagcatcaa gtgattgtca acaatacgct cgatgctatt 1259281 tttatttgtg ataacgaaat gcggattgtt caggcaaatg aagcaacaga aaggatgctt 1259341 caagttgact cggaagattt gaaaaagcgt tctgttttgg attttttgtt ttcaatccca 1259401 aaggatgaac tgaatctttc cgtaaagaag ttttttaaaa aaggctttct gtggaaggag 1259461 gttccgatca ggcttgattg cggggcaaca aaatacatag agtttctggc caaaagaggt 1259521 attggtgagg atttcttttt tgttgtcatg agggacatat cttctaagaa gattctggag 1259581 cgggaattct ctatgaatga acagcttttt aaggacttgt ttgacagagc agttgacgga 1259641 atcgtcctgt ttgataaaga tggcggtttt attgatgcaa atttgtcctt ttgtaaaagc 1259701 tttgaaatca atcataatga gctgtctcat ttatctttgt atgagttcat agacagcggc 1259761 tcacgaaaag atttcgacaa tatctggaag gcgctcaacc gcaagggaaa agcgaagggg 1259821 gagctgcctg tcaagcttcg ttcaggagtt caaaaactat ttgaattcac gattacatca 1259881 aacatcatca gcggttttta tatgtccatt atgagggata tcacagagaa gcggtctatg 1259941 gagctgcagc tctttaaaag tgaggagcgc ttcagagaaa tctttgaaaa tgcaatggac 1260001 gccatcatca tctggtcgaa tgacggaaga atcgtaaaag cgaatcaatc agcctgtaaa 1260061 atttttgagc tgccgatgaa tttgctgttg aaaagaaagc tgtgtgattt tctcgttgac 1260121 tcgcagcaga aatacagcat aacgaagagg aaatacgcaa aatacggaga gatcagagaa 1260181 gagctgctgt ttcaaatggg gaacggccaa ttcaaagagc ttgaatttac ttcaaaacgg 1260241 acaatccttg aaaatcagca tttgacgatc ttaagaaatg taagcgacag aaagcggatg 1260301 gaaaaggagc ttcgggaaag cgagctgaaa ttcagaaaag tgttcaacgg atcaatggac 1260361 ggcaatgtat tgttcgacaa tcaatacagg atcatcgacg ccaacccgtt agcaagccat 1260421 attttgggcc tgtcacatga agagatcaaa cagcacagcc tgttagatat tatttctgct 1260481 tatgaaatag aaaatttggc atcaccggca aggcagatta attttgatga aatggacaac 1260541 gaaattccat ttttgctgag cagcggtgat aacagaaaac tcgaattctc atttaaacgg 1260601 aatattattc aaaatatgaa cttggctatc tttaaagacg taacagagcg aaaagaattg 1260661 gaggagcgcc tgcgcaaatc agataccctt catgttgtcg gcgaactcgc agccggtatt 1260721 gctcatgaaa tcagaaatcc gatgactgct cttaaaggct tcattcagct tctgaaaggg 1260781 agtgtcgagg gagactacgc cctttacttc aacgtgatca cctcagaact aaagcgcatc 1260841 gaatccatca tcaccgaatt cttgatttta gccaagcccc aggccattat gtatgaggaa 1260901 aaacatgtta cccaaattat gagggacacg atagaccttc taaatgcgca agccaatctc 1260961 agcaatgtac aaatgcaact tgatttaatt gacgacattc ccccgattta ctgtgaaccg 1261021 aatcagctga aacaggtttt tatcaatata ttaaaaaacg ccatcgaagt gatgcctgac 1261081 ggcggaaata tttttgtaac gataaaggca ttggatcaag atcatgttct aatctcctta 1261141 aaagacgagg gaatcggaat gacagaagat aaattaaagc gacttggtga accgttttat 1261201 acgacaaagg aacggggaac tggacttggg cttatggtaa gctataaaat tattgaagaa 1261261 catcaaggcg agattatggt agaaagtgaa gaagggaagg gcaccgtttt ccatattacg 1261321 cttcctgtca gacagaatgc tgaagaaaga aggaatgatg aatgaactac tatacgacag 1261381 ccgaaacgcc gctcggtgaa cttatcattg ccgaagagga ggaccggatc actcgtctat 1261441 ttctcagtca ggaagattgg gtggattgga aagaaacggt tcagaatact gagcataagg 1261501 aaacacctaa tcttgcagaa gcgaaacaac agcttcaaga atatttcgca ggcgaaagga 1261561 agacattctc cctgccgctc agccaaaagg gcactccttt tcagcaaaaa gtgtggcaag 1261621 cgctggagag gattccatat ggcgaatccc gaagctatgc ggatattgcc gctgctgtcg 1261681 gcagtccgaa agcggtgcgc gctgtcgggc aggctaataa acgtaacgac ctgccgattt 1261741 ttgtcccgtg ccacagagtg atcggcaaaa acagtgcgtt aacaggatac gccggaagca 1261801 aaacggagat caaagcattt ttgctaaaca tcgagcgaat ctcctataaa gaaaaataaa 1261861 acatatggca cgttcccttt tttcacggcc gacatatcat tttattaagt taaaaaagtt 1261921 ggtctgatga aaaaggagga caaagcaatt gaagccgagc cgctctgaga aacttgccgt 1261981 ttttgccgaa ctgtttgtga aactgcatat cttatcaagc gctcaaaaag atgaaatcat 1262041 caatgttaac aaaaagaaac aaaaaaaccg ctgactcggc tccaaatgag caaagtccag 1262101 cggtttttta atgcaccttt tctcctttaa acagctgttc aatctcttct tcatagtttc 1262161 cggtcataat ccctttttct gtgatgattc ctgaaatgag atcatgaggt gtaatgtcga 1262221 aagcgggatt aaagacaggc acattggatg gagcggtccg aactccggaa atctgcctga 1262281 cttcctcggg atctcgttcc tctatcggga tatcagcgcc gcatttgacc tttgtatcaa 1262341 atgtagataa aggtgcggcg acaaaaaacg gaatatcaaa ggcgtttgct aaaatagcaa 1262401 gaccgtatgt gccgatttta tttgccgtat caccgttctt tgcaattcgg tcggctccga 1262461 cgataacagc ggaaatttgt ttttccttca tcgtatgggc ggccatgctg tctgtgatca 1262521 gagtgacatc aatgcccccc tgcatcagct cccaagcagt aaggcgtgaa ccttgcagga 1262581 caggccttgt ttcacaggca taaatgtgta atcccaaatc tttttgtttg gccaagtaaa 1262641 acggagctag cgccgttcca tagcggcttg tcgcgattga gccggcattg cagatcgtca 1262701 tgatcctgtc gccttttttg aaaagctgca gggcgttttg gccgatcaac cggcacgttt 1262761 cctcatcctc gacctgaatc tgaatggctt catggacaag gtttgttttt gcttcattta 1262821 cggaaatcgc gttttcgacc gaatgactca gtctctcaag cgcccatgac aaattaatgg 1262881 cggtaggccg tgagctgttt aaatattgtt tgatgtcttc cagtctgcgg cggaattccg 1262941 tgacattgtc tgtttcaatg tctttggcag caagcgccag tccgaaggca gctgtaatgc 1263001 cgatcgccgg agcgcccctt actttgagcg tgacaatcgc atcaaataca tcctctttcg 1263061 tcgtcagctc caaatattcc gtctcatcag gaagcttttg ctgatttaaa atggtaatag 1263121 ctgtttcttt ccattcaaca gaacgtggaa cagcaaatga atgggtcatg aatagatcat 1263181 tcctttacaa gtaacttaaa taattcaata acatctgtta tcgttttgaa ttccgaacgt 1263241 ttttcgataa aggctgtgcc ggtttcgagc gccaagcgtt ttctgccgat tcgtttatca 1263301 aacggcacga tcgtatccag gtcagctaca tgggcaaggc cgatcgtgcg tcgtatcagc 1263361 tcacagcccg caaatccgat tgcttcttca aaaatatggc tgagcgtatc agtgaggtaa 1263421 ccgtcgatgt tggcgtaaac atccagactg tccttctgcc aggcttcact aaacgtctct 1263481 tcaaacgttt cccagacctg gttgacatgt tcatataacg gctctctgtc agccccgtca 1263541 cggctgagtg cgttcaaaaa taagttggcg ataaattgcc ctacatcaaa gccgatcggt 1263601 ccgtaaaaag caaactcagg atcaatcacc tttgtttcgt gctcacttgc gaaaatgctt 1263661 cctgtatgca aatcaccatg aatcaacgtt tctgcagacg ttaaaaatga ctttttcagc 1263721 ttagcggctt cgattttaac gctgtcatta ttccaaagct tttcgacaaa aggacgaagc 1263781 tcttcttcaa aatcatttgt gtcatggtcg aagaaaggat ctgtaaaaac aagtctttcc 1263841 gtaatgtcgc atagctctgg atttgtaaac tgtttaacaa gctgtttttt caccttaggt 1263901 tcaagcgcgt aatctgatga gtagaaaagt gtttttccta aaaattcacc gatgtgctgc 1263961 gacagatgag gatagttttc accctcaatg agtccttttc ttgcgatctt gaggtgagag 1264021 agatcctcca tgacggtaac cgccatttcc gtatcagaat aaaacactct tggaaccagg 1264081 tgaggcacat gctcgccctg acggatgaga gcgctgcttt cgattcttgc acggtcgatt 1264141 gtcagcggcc agctttctcc caccactttt gcatacggaa ccgcctgttt aatgatcaat 1264201 gctctgtcat gttcttgatc ataaatatga aaaacgtaat ttaagttgcc gtctccgatc 1264261 tcctggcatg tcagcgtgct tttgcttgga aataggccaa gcttcaccgc caacgccaca 1264321 gcggagcttt catttaacgt ttcgtataaa ggtgtttttg tgactcccat catcataacc 1264381 tccaattatg taattaatta atatgtggcc gtaaaaaagc ctccttctca gagagaagga 1264441 ggcttaacat ctatgtccgc ctctcttatc tctcagatca gatctgaatg gaattagcac 1264501 cgtgccttaa gagaccagcg tctcggcgcg aaaaaaatgc gccccatttc acaatggaat 1264561 tacggtcggt tgcttttggg gtcaaaaggc caaatccctc gcccaactct cgataagaga 1264621 atatattcac ttgtttgaca attctaattt atcagttgat gaacatggta acaggtaatt 1264681 tagttagttg tcaatatatt ttttaatata aatcttttct gatatcatcg aaaacaggaa 1264741 tgctctcccg aacttctgcg ctttcttgaa ggtcgatttc cgctcggact atgccttctt 1264801 cccggccgcc ttcagcaagt acacgtcccc atggatcaat aatcaggcta tgtcctgcaa 1264861 attcattatc cggatttgaa ccggtacaat tgcaggctgc gacaaagcat tggttttcaa 1264921 tggcccgcgc aataagcagg cttttccaat gatcaaggcg gggaagaggc cattccgcag 1264981 aaataaacag cacgttggcg ccttttgtcg tatgttttct gatccattcc ggaaaacgga 1265041 tatcgtaaca gatcaatcca gagcttttga cgccgtcaag ctcaaagtat ccgtcttcgg 1265101 aaccggctga taaatacaga tgctcatcca tcagctgaaa aagatgggct tttctgtact 1265161 ctttaatgat ttgcccttcc ttatccgcga tgtacattgt attataaaca tcagaattct 1265221 tcctgacagc gaccgatccg gcgacaatat gaacaccatg tttttttgcc gttttcttca 1265281 gccagctctg agcggagcgg ccgtcttcgt cagcgagttc atcaagattg gccagatcat 1265341 atccggtcgt ccataattca ggcagaacaa gaacatcagc atgtttgctt tctttttcga 1265401 tgaaaaattc agcctttttt atattttccg aaggttttcc gtatgaaata tcaaattgaa 1265461 gacaagatat cgtccatttc atctttttaa caccccaaat ttttctttac ttttttcatt 1265521 taaccatata tgatgatgga ctatcatttc aagatttttt tagaaggtga gaatagatga 1265581 aatttgaaca gtctcatgta ttgaaggaat tgcctaaaca attcttcgct tctctggtgc 1265641 agaaagtgaa ccgaaagctt gcagaaggac atgacgttat caatctggga cagggaaatc 1265701 cagatcagcc gactcctgag catattgttg aggagatgaa acgagctgtc gctgatcctg 1265761 agaatcataa atattcgtct tttcgcggct cataccgtct gaagtcagcg gctgctgcat 1265821 tttacaaaag agaatacggc attgatctgg atccggaaac cgaagtcgct gtattattcg 1265881 gcggaaaagc cggtctagtc gagctcccgc aatgcttgtt gaatcccggt gatacgattt 1265941 tagttcccga tccgggttat cctgattact ggtcgggtgt cacacttgca aaagcaaaga 1266001 tggaaatgat gccgctcgta aaggacagag cgtttctccc tgattacagc agcataaccg 1266061 ctgaaataag ggaacaggcg aaattgatgt atttgaatta tccgaataat ccgactggag 1266121 ctgttgctac ttccgagttc tttgaagata ccgtgcgttt tgcggctgaa aacggaatct 1266181 gcgtcgttca cgattttgct tacggcgctg taggatttga cggctgcaag cctttaagct 1266241 ttttgcagac tgaaggtgcg aaggatatcg gaattgaaat ttacacgctg tcaaaaacgt 1266301 ataatatggc aggatggcgg gttggctttg ccgtcggaaa cgcttcggtc attgaagcga 1266361 tcaatcttta tcaagaccat atgtttgtca gtcttttcag agcgactcag gaggctgcag 1266421 cagaggcact gttagccgat cagacgtgtg tggcagagca aaatgccagg tatgagagca 1266481 ggagaaacgc ttggatcacg gcatgccggg aaatcggctg ggatgtaaca gctcccgcag 1266541 gttctttttt tgcatggctg cctgtgcctg aaggctatac ttctgagcag ttctcagatc 1266601 ttttgctgga aaaagcgaat gtggcagttg cggctggaaa cggcttcggt gaatatggcg 1266661 agggctacgt cagagtcgga cttttaacaa gtgaagaaag acttaaggaa gccgcttatc 1266721 gaattggcaa actgaacctg tttacccaaa aaagcattga caagacctta taacgatggg 1266781 ataattcaaa ataatttata aaatctatat tttcttatca agagcaggca gagggacgag 1266841 cccgatgaag cccggcaacc gacttataaa gcacggtgct aattcttgca gctagcggct 1266901 gagagataag attcggacga gaaacgaaac ctctttagac gcgattgcag tttgaagagg 1266961 ttttttgata tggatgaaaa tgaaaggagc tctggcatga gtgagttatt agcgacatat 1267021 ctcctgaccg aaccgggagc cgatacagag aagaaagcag aacaaatcgc aacaggattg 1267081 acagtaggct cctggactga tctgcccctt gtaaaacagg agcaaatgca aaagcacaag 1267141 gggcgggtga taaaagttga ggagagagag ggaactgctg catcagaaaa acaagcggtc 1267201 atcacaattg cctatcctga aatcaatttc tctcaggata ttccggcttt gctgacaaca 1267261 gtgtttggca agctgtccct ggacggaaaa atcaaattaa tcgatcttca cttctctgaa 1267321 gcatttaagc gtgcactgcc gggaccgaag tttggcgtat acggcatccg gaagctgctg 1267381 ggagagtttg agagaccgct gttaatgagc atatttaaag gcgtaatcgg aagggacctg 1267441 agtgatatta aagaacagct ccggcagcag gcgcttggcg gagttgactt gattaaagac 1267501 gatgaaattt tctttgagac tggtctagcg ccttttgaaa caagaattgc agaaggaaag 1267561 caaatattga aagaaacgta tgaacaaacc ggacataaaa cgctgtatgc ggtgaatttg 1267621 accggacgta cggctgatct gaaagacaaa gcgagacgcg ccgccgaatt gggagcggat 1267681 gcgcttttgt ttaatgtctt cgcttacggc ttggacgtta tgcaaggcct tgcagaagat 1267741 cctgaaatcc cagttccgat tatggcgcat ccagcagtga gcggagcgtt tacgtcttct 1267801 ccgttttacg gtttttctca cgctctttta ctcggaaaat taaaccgata ttgcggtgct 1267861 gacttcagcc tctttccgtc tccatatggt tcggttgcgc ttccaagagc agatgcactg 1267921 gcgattcatg aagaatgtgt gagagaggat gcttttaacc aaacatttgc tgttccgtca 1267981 gcaggcattc atcccggcat ggttccgcta ttaatgcgtg atttcggcat agaccacatt 1268041 attaacgccg gaggaggcgt acatggacat ccgaacggtg cccaaggcgg ggggcgagcg 1268101 ttcagagcta ttattgatgc ggtcctagag gcccagccga ttgatgaaaa agccgaacaa 1268161 tgcaaggatc ttaagcttgc gctagataaa tggggaaagg ctgaagccgt atgacgactc 1268221 gaaaaccttt tattatttgt gattttgacg gaacaatcac gatgaacgac aacattataa 1268281 atatcatgaa aacatttgct cccccagagt ggatggcatt aaaagacggc gtactttcca 1268341 aaacgctgtc aatcaaggaa ggtgtcgggc ggatgttcgg ccttctgccc agcagtttaa 1268401 aagaagagat tacaagtttt gtattggaag atgcaaaaat cagggaaggc tttcgggaat 1268461 ttgtagcatt tatcaatgag cacgagattc cgttttatgt cataagcggt ggaatggact 1268521 tttttgtata tcctttgctt gaaggcattg tggagaaaga ccgcatttat tgcaaccatg 1268581 cttcatttga caatgactat atccatattg actggcctca ttcctgcaag ggcacatgca 1268641 gcaatcaatg cgggtgctgt aagccgtcgg tcatccatga actttctgaa ccgaaccaat 1268701 atatcatcat gatcggtgat tcggttacag atgtggaggc agcaaagctg tctgacctat 1268761 gctttgcaag ggattattta ttaaacgaat gccgggagca aaacctcaat catcttccgt 1268821 atcaagattt ttatgagatc agaaaggaaa ttgagaatgt aaaggaggta caggaatggc 1268881 tgcaaaacaa gaacgctggc gagagctcgc tgaagtaaaa cgggaattgg cagagagaga 1268941 ttggtttccg gcgactagcg gcaatctgtc aattaaggtt acagatgagc ctttaacatt 1269001 tctcgtcact gcaagcggaa aagataaacg caaagagacg gttgaagatt ttctgctggt 1269061 cgatcaaaac ggagagcctg ctgaaagcgg gcattctctg aaaccgtcag cagaaacgct 1269121 tttgcataca catttgtaca ataaaaccaa tgccggatgc tgcctgcatg tccatacggt 1269181 aaacaataat gtgatttcag agttatacgg agaccaaaag aaaatcacat tcaaaggcca 1269241 ggaaattata aaagcactcg gcttgtggga agagaacgca gaagtgaccg ttccgattat 1269301 agaaaatccg gcacatatcc cgacgctagc ggcactgttt gcggaagaga tttcagaaga 1269361 ttcaggagct gttctgatcc gaaatcatgg tattacggct tgggggaaaa cagcatttga 1269421 ggcaaaaaga gtgcttgaag cgtatgaatt tttgttcagc taccatttga aattgaaaac 1269481 actcgagcat cagctggtta aataaaagga ggaattgaaa tggctacaat tcgaattcat 1269541 gatgaggcaa atacaacgat tgaaaatcaa gaggaagtgg caagctttct ggacagtcaa 1269601 gaggttattt atgagcaatg ggatatcacg aggcttccgg aacatctctc agagaaatat 1269661 gacctgacag aagaagaaaa acagcaaatt cttgatacct tcgaaactga aattaaagat 1269721 atctcaaccc gccgcggcta taaagcacag gatgttattt cattgtcaga cagcaatccg 1269781 aaacttgatg aactgcttga aaactttaaa agagagcatc accatacaga cgatgaggtt 1269841 cgttttattg taagcggaca cggtattttt gtcattcaag gccaggacgg cacgtttttt 1269901 gatgtccgtt taaaccctgg agatttaatc tccgtgcctg agaatatccg ccattacttc 1269961 acgcttcagg aggaccgcaa agttgtcgcg gtgagaattt ttgtcacaac tgaaggctgg 1270021 gttcctattt atgaaaaaga cagcgtgaat caataagcgt gagatagccc cgttcatcga 1270081 acggggcttt ttatatttat tgcaaacgcc acttttcata ttgtgacagt tcttttttaa 1270141 tcagtgtcca aatcaaacct aaaacagctg catcgtcaat gaatccaaga ccgaggatta 1270201 cgtctggaat gatatcgagc ggcatgacga tatacaggat tgcggcagtt aacagcaaaa 1270261 gtgttttaac ctgtgaacga gggtagtcgc catttcgcca atcgcgaagc atctgaaaaa 1270321 aagtagtgat gtgctggata catttttttc ggtttttcct ctttaaaatc gcttttccgc 1270381 ctgccgctcc gagcattatt gctttctttt tcttcattgg gcatacctcc tgcctggcgg 1270441 cgtgtttaag atattcttca cctgggtatt gttcttctaa tcctatcaat atatctatta 1270501 tacctgaaaa attaacttat ttaatgaaaa tatgtttaca aataaagtat aatctgtaat 1270561 aatgcacaat aacccaatca aacttgtttc ctatttctta gcggcgaggg gtgaagtgaa 1270621 tgggcggttc ttctgaacaa gaaagattgt tggtgtctat tgatgaaaaa agaaagttaa 1270681 tgatagatgc cgctagaaag cagggattta cagggcatga cacgatcagg cacagtcagg 1270741 agctggattg tttaataaat gaatatcatc agcttatgca agaaaacgaa cattcccaag 1270801 ggattcaagg ccttgtaaag aaattaggct tgtggccccg cagagatgtt atgccagcat 1270861 atgatgcaaa taaatagcgg cctatcagat gcatatataa agagagagct tttcggaagc 1270921 gctctttttt tctggaaaaa attcatatga aagagggaac taatgaagga actggcgatt 1270981 ctcattaccg aaatggtcaa tcaatttcat gatgctttta tttccttatg cggaatattt 1271041 ggcattcatt taactgacaa agaaatgcat ttttgggtga tcggcatttt tggcatattc 1271101 tttttcggcg tcactcacgc tgtgtttaca tggctttcta aatggagtat gacagccttg 1271161 tcctttatct ataccgttac agtcatcatt gtcatcgtat ttgcgattga gattcagcaa 1271221 aaggtgacgg ggagagggaa tatggagttt ttagatgcca cggaaggtat aaagggtttt 1271281 ttagtatttt ttatgttttt tttgcttttg aaaatgctgt tgcgtttcat caaaatcctt 1271341 ttttctggaa gaccagcaag caaatcgaat ggcaatgccc gatcacgaag ataaaaaacc 1271401 ctcctgacat ggtcaggggg gctatgatgc ggatacgggg agggtgatcg tcacctctgt 1271461 gcctcttcgc acttcacttt caatatgaat agagcctccg tacatcagca cgatccgttt 1271521 acaaacaaca aggccgagac cggttccttt ttctttagaa gtaacaaagg gaaggaagat 1271581 gtgatccagc atttcctgag aaatcccttc accgttatcc acaactttga ttatggcttt 1271641 tttatctaaa gctcctaggg agatcgtcag tttgcctcct tcaggcattg actcgaggcc 1271701 attttttgct acatttaaaa tcacttgttt aatatgatct tttgtacatt ttacgagtaa 1271761 gggctgctcg gttagatact gtaattcgac ttcaacattg tatagattgc cctcagaata 1271821 aatgatcggc ataatttctc cgataatgtc ctgaagtgag ttcagctccc atttttcagc 1271881 tgtcggcttg ccgagaacga gaaactcact cactatttga ttgatgcgct ttatctcctg 1271941 ttcgataatg gagaagtaaa gctgatcttc ctcaccttta tatttctttt gcaacagctg 1272001 aataaagccg cttatcccgg tgagggggtt acggatttca tgggctgtgc tggcagcaag 1272061 cgtcccgatc agctctaatt tttgcgcctc gttttctgag cgctccagct gggtctgccg 1272121 cttcagcaaa taatacagca cgagaataaa aaggatattc agcagaacaa taatacatga 1272181 aagcggaagc acaaggcttt tcgacagttc ttctattgtg accgggttcg gatagacttt 1272241 catattccag ctgatatcat ccagatatcc gctgacaggt ttctgatcct ctgcatgaga 1272301 ggcttgtccg ctcgcaaaaa tcattttccc gtcttggttc acaacttcaa tataaacatc 1272361 agggcttagt aagttaatga gatttttcaa ataatcaatt tgaatagctg cgacaagata 1272421 atctgtcaca ttacgttttg agtccaaaac aggcacacaa attgtgaaaa ttggctgacc 1272481 agtaattctg ctcgaataac tatctgaaat gactgtcttt ttagtttcct ttgcttttat 1272541 aaaaaaagat ctgtcggcca ggtttacttt cgtttttaat tcggttgtgc ttgcggtgac 1272601 gtctcctttg gcattgagaa aatagagacc ggaaaatctc ggctctgaat caaaggtctt 1272661 ttccaaaatt gattgcattt tctttatatc aaccggtctg tcgatggcga tggacaagga 1272721 ggtcattctc gccattgttt ctccgattaa ataattgatt ttgttgcggt gaaggtttag 1272781 caggacactt gcttcttgtt tatgttctgc agctattgta tctttttctt tttcatatac 1272841 gaaaaagctg atgacgattg ccggaatcac gaccagtatg atataaagtt tgactctccc 1272901 gcaggcgcct tttagtattt tcaatttgca tcgctccaac atacacctga ttagaggtat 1272961 tatatcattg tttcttcttc tttaataaga aaaaataacc aaaaaaatta gaaaaagatg 1273021 ttggcaagct tacattttaa aaaagaagag aaatattgga aagattttta ttgacatttt 1273081 ggtctttgtt tattaatgtt tctctgtaac ggtttctaaa aggatgattg agacatgaca 1273141 gaaaaatcac tgaagttatt tatcgtgctg tcgcgcgcgt atcggtctat taacgatcat 1273201 atgaataagc atattcataa gcatgggctg aatccgactg aatttgctgt gctagagctt 1273261 ttgtaccata aaggcgatca gccgctgcag cagataggag ataaaattct cttggctagc 1273321 gggagcatca catacgttgt agataagctg gagcaaaaag aacttctcat tcggaaagcg 1273381 tctcctacag acagacgagt gacatttgcg caaattactg aaaaaggcat cggtcttttg 1273441 aacgatattt tccctgatca cgctgctgaa attgatgaaa tgatcagcgt attaagcgaa 1273501 gaagaggtag agatgtgcac cgaaatgtta aaaagagtag gattaaacgc aaaacagttt 1273561 cataataagt aaaaaaagga agcctgatat gtcacaaggc ttcctttttt gctatttttc 1273621 atttgtttcc gctgcgcctc tcggcaaaat gagaacttca acccgccggt ttttgcttcg 1273681 gccttccgca gttttattgg aagccaccgg tttatactcg ccataaccct tggcgctgaa 1273741 cacttttgca tcgagcttgg ggttttcaat caggagcccc ataaagttta ccgctctcat 1273801 gacgcttaaa tgccagtttg attggaattc agaattttta attggcatat tatcagtatg 1273861 tccgctgata atgatatttc ttggcgggtt aatcacaaga agatttgaaa tctcttttgc 1273921 aagcggcaca tcttccttac ggatggtcgc ttttccagaa tcgaagaaga tgctgtcttt 1273981 aatcgtaatc agaaggcctt cactagtcat cttcgtctcc agctgatgtt ccagcttttt 1274041 atctttgatg aacttttcca cctggctctt cacattttca agttcttctt gatcagctgc 1274101 tttttctttt tctttcttgt ttttctcttt ctcttctttt tcctttttca cttcatcgat 1274161 gccgtctgac tcgttttcag gaggagtgac actggagtag tccagtacac cggttccgcc 1274221 tgtaaaaact tcattaaatg attttgagag catttgaaac ttagctgcgt caatcgagct 1274281 gctcgcgtac agcacaataa acaatgccag gagaagagta aggatgtcgg cgtaaggaac 1274341 gagccatgat tcatcaacgt gctcgtcctc atgcttcttc ttcttttttc tcgccatttt 1274401 gcgcctctcc ttgttctgca aatttcaagc ggtccttcgc aggaagatac attaaaagct 1274461 tttgttcgat gactttcggt gcttgtcctt ctaaaacgga taaaacacct tcaatcatga 1274521 cctcacgcag ttttacttcc tgttttgatt ttcgttttaa tttatttgcg aaaggatgcc 1274581 ataacacata ccctgtaaag ataccgagaa gtgtggcaac aaaggcagca ctgatggcgt 1274641 gtccaagctc atctgtgtta tccatatgag agagagcggc aatcagcccg attacagcgc 1274701 cgagtactcc aagtgtcgga gcgtacgttc ctgcttgtgt aaaaatagcg gctcctgctt 1274761 ggtgcctgtc ctccattgct tcgacttcct ctgtcataat atctcttata aattccgcgc 1274821 tttgcccgtc aacagccatg ctgagcccgt ttttcaagaa agcatcatct acatcctcaa 1274881 tgcttgcttc taaagcaagc agaccttcgc ggcgtgcaag ctgagcccat tcagagaaca 1274941 taggaatgag ttcctctatt gtgagctgtt tattttcctt aaataacact cgaaacagcg 1275001 taggcacttt tttaatttct tttgttggga acgcaataac gactgctgag attgtcccgg 1275061 cgataataat taaaatggca gcggggtttg caagggcgct gaaactgacg cctttcagaa 1275121 ccatcccgac gctcaatgcc acaaaagcaa gaataatacc gattaacgaa gttttatcca 1275181 tagttttcac caaatccttt tttactagct tgtctatggt taatatcggt tttggtgccc 1275241 ggaactttag ggacattgtg aatttgttca tgaaatattc aaggaagagg catagaaggg 1275301 agaaataaac aaaaacgggc tctccaaaat tgaaaagccc gggggtctac tgaaattagc 1275361 agcttgcttg caagctgtcc ttcagatggt attcatataa tagtagaaat acatattcac 1275421 tgtatataaa catgttccat ccctccttaa aaaagtgtaa aggatgaagg gaagtagcgc 1275481 ttcaggagaa gggacggtaa tttctaagtc aagagtatga aagtataaaa aaaagcggct 1275541 tcctaaaagg aaaccgctga ttgttatttt gctcgcactt tgattttatc atcttctaaa 1275601 atcacgtgaa aacttgtgat ctcgccatta tcaagcagca gatcggtcat ttcatcctca 1275661 acccattctt ggatggttct tctaagcgga cgtgcaccga atgaagggtg gtagcccagc 1275721 tcagcgattt tttctttcgc ttcatctgtc acattcaagc taatgccccg ttccgccaat 1275781 gtttcttcaa gttctccaag aagaaggctg acgattttga caagatgttc tttttccaat 1275841 gagcggaact caataatgct gtcaaaacgg ttgaggaact caggtttaaa gaacatgctc 1275901 agtgaatcaa ttaatgtttg ttcttcgatg acactgtcat ctgattggaa accgactttc 1275961 gtttgtttct caccagcacc cgcattactt gtcatgatga tcacagtgtc tttgaagctt 1276021 acagttctgc cttggctgtc tgtcagacgg ccatcttcca taatttgcag gaacatatgc 1276081 tgaacgtctg ggtgtgcttt ttcaatctca tccagcaaca caatgctgta aggattgcgg 1276141 cgcaccttct cagttaattg tccagcttcc tcatggccga catatccagg cggtgaaccg 1276201 ataattttag atacggcgtg tttctccatg tattcgctca tatcgagtcg gataatagcg 1276261 tcttttgtgc cgaataattc atctgccagt gttttagaaa gctctgtttt ccctacgccg 1276321 gtaggaccga cgaagaggaa ggagccgact ggtctgtttt tggattttaa tccggcgcgg 1276381 cttcgtctta ccgcttttgc cactttttga acagcggctt cttgtccgat cacgcgttca 1276441 tgaagttttg cttcgagttc tttcattttc gtttgttcgt ctgcctgcag tttgccgaca 1276501 gggatgcctg ttttttgttc aacaatttcc tgaatgtgct cagcttccac agtgacagcg 1276561 gtatgagcgg aggagctgtt cagttttttc tccaatgcga gttcttcatc acggagtttt 1276621 gccgccagtt cgtaattttc ttcttccagg gcttttgttt tttcggcttc aattgcagtt 1276681 aagcgttcag cggcatcctc atcattcagt tcatcaatta acaggttggc ttttgaacct 1276741 gcttcatcta ataaatcaat tgctttatcc ggcaggtgtc tgtcctgaat gtagcgggat 1276801 gataaagtga cacatgcttt gattgcttca tcactgaatg ttacgccatg gtacgcctcg 1276861 tatttgtctt taatcccttg cagaatgagg atagcctgtt caattgaagg ctcctgcacc 1276921 atgacaggct gaaaacgtct ttccagcgcg gcatcttttt cgatttgacg atattctttc 1276981 agtgttgtcg cgccaatgac ttgcagttcg cctctggcta gggccggttt gagaatgttg 1277041 ccggcgtcca ttgatccttc tgcagagcct gcgccgacga gaaggtgaat ttcatcaatg 1277101 aacagaatga cattttttcg ttccttcagc tcagtgatca gctgtttcat tctctcctca 1277161 aattggcctc tgatccctgt gtttgcaaca agagatgcaa catcaagcaa gtatagctct 1277221 ttgtttttta gtttgtttgg aacatcacct tcagcaattt ttaaagcgag cccttcagcg 1277281 atggcagttt tccctacacc cggctcacca ataagaaccg gattgttttt gtttcggcgg 1277341 tttagaattt cgatcactcg cgccacttca tcatcacggc cgatgacggg atcaatgaga 1277401 ccggcttttg caccgtttgt aatattttga gccagctcat caagcaaccc ttttttttcg 1277461 ctttgttttg ctgcgctctg ttctttcggc tggaatgcct gttcaaacgg aaatccgaaa 1277521 gattgaggac ccatactcat tgaaggttta cgggtcagtt cgttatagca agtttcacaa 1277581 agaaccatct gtttatgaac ggaatttatt tgcatgttaa ggcgaatcgt cgcctcgttt 1277641 tgatgacaat gttgacaacg catttgccaa aacctcctta ataatttgat catctttgac 1277701 caatgaaagt gaataaaaag gtctattggg tttgaccttc tttgactatt agtatacggc 1277761 aaacttaacg gcattcaaac caatatgctc aaagcagact gaatatttga ctatctttga 1277821 ccaattgatt tttaaaaaag gccggtttgt ttgaccaact ttgattaata gtatactctg 1277881 actatctttg actttcaagt cttatgcaca aaaatttttg atttgttaca aagtaaaaca 1277941 tgttttcttc gtcttttcaa ggaacttgtc tcataggtta taaaaaggca tatatggaca 1278001 aaactgcggt tcgttcggag ggaagaaatg gaacaatcaa aagggtctgc aagtcagctt 1278061 gcttttgtgt atgtcggcac agtagtcgga gctggatttg cgactgggag ggaaattgtt 1278121 gagttttttc tgaagttcgg ctggttcggt tttttcggca ttctcgtcag cggcggaatg 1278181 tttacgttac tgggggccaa gctgatgatc atttcaaagc gaatcaatgc caagtcatat 1278241 caagaaatga acatattttt gttcggggcg acggctgggc ggattatcaa tgtatttatg 1278301 ctgtttgttc tccttggagt tacatctgtt atgctttcag gggcaggggc gctttttgag 1278361 gaacagctgg ggatgtccgc tcagattggg atgctcatta caatcggtct gagtttaatt 1278421 gtgatgacta gaggagtaaa aggcattttc ggtgtcaatg tgtttgttgt tcctctttta 1278481 atcatctttt caatgattgt ggtggccgac tcttttatat tcagcgaatc acgaaacgca 1278541 gctcagtggg tctggccgca tcgctgggat tggctgttat cagcagtttc ttacggggct 1278601 ttaaatttat cgcttgccca agctgttttg gttccgctgg cgaatgaaat gtcatcggag 1278661 aaagtgataa aaaaaggcgc tttaatcgga ggcacgatgc tgacgattgt gctgtccgcg 1278721 agttttctgt ctttgtcgac tcttccggat gtatttttgt atgatatacc gatggcgcaa 1278781 gtggtttatc tctttgcacg atctgtccat ttgatttatt tactcattat tttcggagaa 1278841 gtgttcacat cagttatcgg taatctatat ggattagaaa aacaagtgca aagctttctt 1278901 ccagtgaaaa gcaaatatat ctttgcagcc attatgatca cggcttatat tacgagccaa 1278961 atagggtacg gcaggcttat ttcaacgatt tatcccttgt ttggctatgt gagcctggcc 1279021 ttcataggcg ctttgctttg caaaaaagct cctcggcggc gcagtttata aatatatata 1279081 atgaaacgaa ccgtcactat agagcgataa ttgatctagg aaccggggac tgactttttt 1279141 attgtcaaga aaaacatcat tatggtaaga tagcagaagt gaaaaaattg aagaaaatcc 1279201 gtgcgatatg cgggagaggt tctagctaca ccctctataa aaaactaagg acgagctgta 1279261 tccttggata cggccttttt tatgtttttc tagagcacct tccgaaaaaa ggtgtttttt 1279321 tgcgtgaatt agctgtagcg atgtctctcg ccggcgtttt tattgcggag aaggagagga 1279381 atcatgaaaa aagaaaaagc aattgtcgta tttagcggcg gtcaagacag cacaacatgc 1279441 ttactgtggg ccttaaaaga attcgaagaa gtcgaaacgg tgacttttca ttataatcag 1279501 cgacattcgc aggaagttga agtggcaaaa tccattgcgg aaaagcttgg tgtgaaaaat 1279561 catttgcttg atatgtcact tttaaatcag cttgcaccga atgccctgac tagaaatgat 1279621 attgagatag aagtaaaaga cggcgaactg ccatccacat tcgttccagg ccgcaatttg 1279681 gtattcttat cctttgcgtc tatcctggct taccaaattg gcgcgcgcca cattattaca 1279741 ggagtttgcg agacagactt cagtggttat cctgactgcc gtgacgaatt cgtgaaatct 1279801 tgcaatgtca cggtaaatct ggcaatggag aagccgtttg tgatccacac gcctctcatg 1279861 tggctcaata aggcggaaac gtggaagctt gcagatgagc ttggcgcgct ggattttgtg 1279921 aaaaacaaca cgctgacatg ctataacggc atcatcgcag acggctgcgg cgaatgtccg 1279981 gcatgtcacc ttcgttcaaa aggttatgaa gaatatatgg tgatgaaagg agagcgtgca 1280041 taaattgtta tctcaaattt atccgcaggc ccagcatcct tattcgtttg aactgaataa 1280101 ggacatgcat atctcagccg ctcattttat ccctcgggaa agtgcgggag cgtgcagcag 1280161 ggttcacggg catacgtata ccgtaaatat aaccgttgcc ggcgacgaac ttgacgattc 1280221 aggctttctt gtcaatttca gcgtactcaa aaaactggtg cacggaaact atgatcacac 1280281 gctattaaat gatcatgaag atttttctca ggacgaccgg tattcgctgc cgacaactga 1280341 agtcgtggcg aaaacgattt atgacaacgt acaggcttat ttagacactt tggagaataa 1280401 gccgacctgt gtacaggtgt ttgtccgtga aacaccgaca agctactgtg tctaccgtcc 1280461 gaaaaagggt ggtttgaatg gctaaaggaa ttcctgtatt agaaattttc ggcccgacga 1280521 ttcaaggaga aggcatggtg atcggacaga aaacgatgtt cgtccggaca gccggctgcg 1280581 attattcctg cagctggtgt gactccgctt tcacttggga cgggtctgct aaaaaagata 1280641 ttcgctggat gacggcggag gagatttttg cggagcttaa ggacattggg ggagatgcgt 1280701 tttctcatgt gacgatctca ggcggcaacc cggctctgtt aaaacagctg gatgctttta 1280761 ttgaactgct gaaggaaaat aacatccgtg cagcgcttga aactcaaggg accgtttatc 1280821 aggattggtt tacgctgatt gatgacctga caatttctcc aaaaccgcca agctcaaaaa 1280881 tggtaacgaa ctttcaaaag cttgaccaca ttttaacttc acttcaagag aatgatagac 1280941 agcatgctgt cagcttgaag gttgtcatct ttaatgatga agatctggaa tttgccaaaa 1281001 ctgtgcacaa gcggtatccg ggaatcccgt tttatttaca agtcggaaat gatgacgtgc 1281061 atacgacaga tgatcagtca ctgattgcac atttgcttgg aaaatatgaa gcgcttgttg 1281121 ataaggtagc tgtcgatgcg gagctgaatc tcgtcagagt gctcccgcag ctgcacaccc 1281181 tgttatgggg caacaaacgc ggagtataat agaaaggaag atgaacatga cgacaagaaa 1281241 agaatcagaa ttagaaggtg taacattgct aggcaatcaa ggtacaaatt atttgttcga 1281301 atatgcaccg gacgtgctgg aatccttccc taataaacat gtaaaccgtg attactttgt 1281361 aaaattcaat tgcccggaat tcacatcttt atgtcctaaa acaggccagc ctgactttgc 1281421 gacaatctac atcagctaca ttcctgatga aaaaatggtt gaaagcaaat cattaaagct 1281481 gtatctattc agcttcagaa accatggtga cttccacgag gactgcatga atatcatcat 1281541 gaacgacttg attgaattaa tggacccgcg ctacattgaa gtatggggca aattcacgcc 1281601 aagaggcgga atttccattg atccgtacac aaactacgga aagcctggca cgaagtatga 1281661 gaaaatggcc gaataccgta tgatgaacca tgatttgtat ccggagacaa ttgataatcg 1281721 ttaattattc cgttgtgtga tacggagtgt aaaaggaagt ggagtcacag taaaatccga 1281781 acattcagcg ttaattttca gcggaaatgt gacctggtca cagcgaagtg tgacccgcac 1281841 taagctcaat aaaagtggga aaagtcacac ctgaaaatgg ctctactcat gggaattgta 1281901 ttaaaaagtg tgacctgagg tgcaacctga actgtgactt ttatgcagtg aaaaattgat 1281961 agtacagaag cagattaagg cgtacaattt gtacgtcttt tcttttttat ccgaaagaaa 1282021 aaatgcctat ctagagatca taggcattaa atattattat caatatcttc atttattttt 1282081 tggctaagtt tctgaacctt ctctttaaca tttgaaacag ctcttttttg aatttcatca 1282141 attctcctga atatagtcga tgacacttct tattagaact tcactttcaa aattgaatat 1282201 ctcatttatt tctgactgtt cttcatctgt taggtgatgg tattgaagtt gtttagcatt 1282261 tacttcagca gctacatcaa tcctaactta gttgttctgg ttgtacaatt tcatattcac 1282321 cttctgcata ctcttgctcc gcataatagc ctccccattg acagagctcc tgcaagatag 1282381 gtttaagaga ttctccaagt tcagtggatg aatattcaac cttcggcggt acttgattat 1282441 acatctttct gctcacaagt ccactggctt caagctctct aagtgtttga atcagcattt 1282501 tctgagttat atttgggata atgcgcttta attcactcgt tctctttggt ccattcatta 1282561 aaaagtataa tacaaggcct ttccattttc cgccaataac ttcctttgtc acttcaaacc 1282621 cacagctaaa ttttttcatg tctaaagctc tccattccac atttattact ttttagttac 1282681 tatatcacaa aaaagtgggt acttccgata atgtgcttac tgaaggatac tatatcttgt 1282741 aagttgttct tcaagtactt aaaggtacta gacataaaat aaaattaatt ctaaaggagt 1282801 gttaagtatg ggtaaatttg aaggtaaaat agcgcttgta acgggtggaa caagtgggat 1282861 tggtcttgct acagcacaaa aatttgtaaa cgaaggtgca tatgtttata ttacgggacg 1282921 tagacaaaac gaacttgata aagctgttaa ccaaattggc aagaacgtaa ccggtgttca 1282981 aggtgatatt tctaagcttg aagacttaga caaactatat gacattataa agcaggaaaa 1283041 aggtaagttg gacattcttt ttgctaatgc aggcatcggc aacttccttc cattaggtga 1283101 aattactgaa gagcaggttg atagaacgtt cgacattaac gttaaaggaa ccatctttac 1283161 tgttcaaaaa gcgttatcac tattcccgga caaagtaggt tctattattg taacgggctc 1283221 tactgctgga tcaattggca acccagcgtt tagtgtatat ggagcatcta aagcagcatt 1283281 aagagcacta gttcgcaact ggattcttga cctaaaaggt actgaaatcc gtgtaaatgt 1283341 ggttagtcca ggaggtattc ttacacctgc ctacgatgag ctttttggtg atgcacttga 1283401 agaggtactg gaaaatagca gaaatactgt tccagctgga aaagttggga cacctgaaga 1283461 agtagcaaac gctgtatctt tccttgcttc agacgaaagc agttacttga cgggtgttga 1283521 attgttcgta gatggcgggc tagcacaggt ataatttcac tgcgcagaga ttacaaatag 1283581 tccccaaaaa aggttaatgg ggatttactt gaagaagtcg tataaaaaag tcgttttcct 1283641 taaaggacag ggaattcgac ttttttatat ttgaatttga ttaacgttgt aaattcgcat 1283701 tttcctgggg ctactactaa atgacctgta aaaaagatta cactgtgaat aaatgtactt 1283761 aaagtaacgg gggctcttga cttttaataa aaaataatat ccctgtcctt gtattctaat 1283821 acttttaaaa atatttaaag gaatccttat gtcctgaata accacatagg aaaatatgtt 1283881 gtaggttgct ttcttttttt gtggggcatc ccacacaagc tatctcgtga tctcacacct 1283941 gaacgttttt tatagactag taccgcgaca agttatatta catatacata ccaataaagt 1284001 agacattaaa aagtgaaaga gaggatggaa atgtgtgaaa attcttttcc ttgagagtca 1284061 tcccatgtgg ctctatggtt taccgaatgg gtttagggaa gcaggacata ccgtaatgat 1284121 ttccggtcct gtaagtcggg aaaatataac tgaaatgata gacgaattta aaccagattt 1284181 aatagtatct atgggatgga caccagagca ttcaagggaa aagcaggcct ggattcgcaa 1284241 cgctactaaa aaggtgaata tccctctcgt ttattgggca actgaagacc cgctgcacac 1284301 tcaaaacttt actatcccgt taattaaaaa gatgaaaccg gattttgttt tcacggtcac 1284361 gccttctctg tgtaaaactt atgaaagcat ggggattaaa gcagctcact tagactttgc 1284421 atttcacgaa agtatacatc accagattaa accattagcg aaatacagtt gtgatatagc 1284481 agtggtggct aatgcttacc ctaattttct tgaagaacat ccggaagtgt tccgttcgtc 1284541 ctctttaaaa acgcttattc gtcctcttat acggaagggt attcgcattg atttttgggg 1284601 gagaaactgg gaaaaaatga gtaaatatat aggaagagaa attccccgca attggatcca 1284661 tggatacctt gattatactg aagcatataa agtttacagt tcagcaaaaa tcattatcgg 1284721 tttgcaaaac tgtgaaagcc aacttacaca acgcacctat gagattcttg gttccggggg 1284781 gtttttattg acatcggata caccagcagt tcgaggtaaa ttcaaacctg gccgcgatct 1284841 catcgtttct tcctccccaa aagaaacatt ggaaaaggtt aaatactatt taaatcatga 1284901 tagcgagaga aaaaagattc agataaacgg taaaaaggct gtaaagaatg attcctatcg 1284961 gcatagagcc gagagaatgc ttgaggtgct aaaaagcaga ggaatcataa gaaacttagg 1285021 ggaaaccatt cattatgtag atgttctcaa agaaaaatac gtgatccatc atgttactcc 1285081 cggtgaaaca ttatcaataa ttgccagtaa gtataatgtt tccctgcagc aactcatgga 1285141 gcttaatcat ttcaaatcag atcaaatata tgctggacaa atcattaaga ttagagagaa 1285201 actgtttaga aatattaata acaaattatt ctaaaggaga gtaatatgaa tgaaggggaa 1285261 aatacctaaa ataagaaatc aagcgaataa agtaaaaaga acgcctcgtt atatggaatt 1285321 tcccgtgaca tacgaagtat atcatgtgga atccggcgat acattatgga cgattgccaa 1285381 atcctttgaa attccggtac aacaacttat gaatcttaat aagctttctt cagatagaat 1285441 ttatcctgga caaattataa agataagaga aagataatct ttgaggtttc ggaagcgaat 1285501 caaattgaaa tgacaatcct cattttttta tttgtgggga acttgatatt tttggggatg 1285561 aaggggttat gagatgtttc aaatgagcta ttactattct ggattaggat gggactttat 1285621 tcaacacgtt gatcaaacga acggagtatt aaatgttgtg tctcctgatt ttttctatat 1285681 cagaaaagat ggatcattac ttctccgttc agctaatccc gatgtgatta aagctcttca 1285741 tagaagaaaa ttaaaagtag ttccttttct aagcaatcat tgggatcagg atttgggacg 1285801 atttgcatta atgaaccgag ttcttttagc taaacaaatt tctcatgcaa tagaagaact 1285861 ggatttggat ggagttaata tcgatataga aaaccttaca gaaaaagatc ggaatctatt 1285921 tacagatttt attagattag taaggaaaag tattcctaga cataaagaag tatcagttgc 1285981 agtggcggca aatccttttg gctggacgaa gggctggcac ggatcatatg attacgagta 1286041 tttagctaaa tatgcagatt atcttatggt tatggcctat gatgaaagcc gccttgctgg 1286101 gcctactgca agtgtaggat gggtggaaaa gtccattcaa tatgttctga cccaaaaaat 1286161 ctctcctcaa aaactagttt taggattgcc attctatggc cgctgctgga tggaaggcca 1286221 atctgcctct caagccattc ccctttacct tgttgttagt aaaaaggcat agcgggacaa 1286281 ttatttttga caccaagagt caatctccaa aagctatttt tactgtcaat cacgataaaa 1286341 aggggccgtt gccttcggga acatatacat tatggtttga aaatgaacag tcactcagag 1286401 caaaaataaa actcgctcaa aaatataatc tgaaaggtct tggcagctgg agtcttggac 1286461 aagaagatgc gtcagtctgg aatacagtgt ttaaaaatat ataatgattt atagttcaga 1286521 acaaaattcg aagataattg caatgaatct ctaaatggac atactgaaag gagtttatta 1286581 cgagtgcggg taaaacagtg agggcattcc ataggccctt ctcccaaaat gttctacacg 1286641 aggcattaca ttgggcttga aatacacatt caaacttatg ttatagtacg cattttacgg 1286701 atgtgttgaa tttattctgc ttccatgatt taatcataca catgctactt gatagcaggg 1286761 ttatcgcatt tcattcagaa ttgttcagga tcgatatgga agcgcacgac taactagaac 1286821 tttaaaagca tacactcata tacttcctga atggatgctg gtttatctaa aaaacatgat 1286881 gagaattgat tgtacgcatg gtgaagcatg acttgttgat aatcgaccat atggtttctc 1286941 cttagaaatg agggggtttt tacataaaaa agacgagcga atccgggggg aattccactc 1287001 gccgctttct aatgaaaaga cgggatgctg gatggcagct cgtctgtttt attataattt 1287061 aacgaacgta tgtttgtaaa ggtgtctttt cgaatgaatt ggttcatata accgttaaga 1287121 acagattcat tgtaaacatt cgctaaggta tgctaagatg catggactat aaaggagtga 1287181 tatgaagtga agacattgcg gttaaacaat gtaacgttag aaatggctgc atatcaagag 1287241 gagagcgagc cgaagcgaaa aattgcattt accttaaacg ttacgagtga gacttaccat 1287301 gatatcgctg tcctgttgta tgaaaaaacg tttaatgtcg aggttccgga acgcgatctt 1287361 gccttccggg gggaaatgac aaattattca acatcattga ccaacctgta cgaaccaggg 1287421 gccgtcagcg agttctatat agaaataacg gaaatagaca aaaacgccga ttcatgatcg 1287481 gtgtttttta tgtaaaaaag ctgccggccg gcagcttttg agaaagcgaa tttcatatgt 1287541 aaggtgttaa attgtccgtc ttgcagtttt ttgaataaat gtggaaataa ggaggtttta 1287601 ataggagtct ctgatgatct tataattttt atgattaaca actgtcaatg aatctaactc 1287661 aagatcccga tagttatcca tgatcgtcac atcaacgata acagaattct catttacttt 1287721 ttcaacaaca ccggttaatc cgtttttaaa ttcaatgaca ttcccaacct tagcgatttt 1287781 cacaagcttc ctctccttta aacataataa tgccttttga aagtattttg cagtattttc 1287841 attgagaagt aaagcgataa ggagttttat ctcccttatg aattgttctg tcgctataaa 1287901 gatgatatat tgattttcgt caatagaaag aaaagggggg aatttttgtt gcgtcccgaa 1287961 gaaataacag aaatgattga acagctgcgc accggcgcca taaacgaact gagagtccag 1288021 aaagagcatt ttcttgattt cagggccgtg ttatctaaac aagatgattt taaacatttc 1288081 cgaggaattg cccagcaagg cggagatgtt atctttcaat acttagaaca gccaagaagc 1288141 tgaaggtttc tcatacgtga gaagcctttt tatcatatat gacagaacac aagcctttta 1288201 ttacagctgt ctgtaacagg tgtaaataaa atgtaaagta ccaaagatgg ataaacatgt 1288261 tttaatttaa caatatttat agaatttcag actgtttttt tgccattaag cagtgagtca 1288321 tcctctttat tccatcctga tacctccttg ggagagttgg aaaatctttt tccgtgaaaa 1288381 tgaatggatc tcttgttaag gttatgaagt gttttttgga gcactttaag gaggaaactg 1288441 tatgacaacg aaattcactg ctctggctgt ttttcttctt tgtttcatgc ctgcagccaa 1288501 aattgagcat acacaagctt cactactgag cgcaaagaag acaaaacatg aagaagcgaa 1288561 atggcttaca catatagatc gaaatacgaa tgaatctttc ccttcactgt ctgctgataa 1288621 agacaagaaa ataaaaccga ttaagctatc agcacacact gaaaagaaag agaaagataa 1288681 accggacaaa acaaatgatg agaaagaaac atatacacag tctgaaaaag agttgctgtc 1288741 ccgtctcgtt cacgcagagg ccaaaggaga atcatataaa ggcaaggtcg ctgtagcaag 1288801 cgttgtactg aacaggacgg agaaaaaagg ttttcctgat acgataagag gagttattta 1288861 tcagaaaaac gcctttgaac cggtcgcaaa cgggagcatt aaccaaaagc ctgataaaga 1288921 atcgattgaa gctgccgaag aagcgctgtc ctcaaaaaat agagaaacag atgccatatt 1288981 cttttataat ccgaaaacag cgtcagataa ttggattcgt tcaagaaaaa tcgtagaaaa 1289041 aatcggcaga cacgtttttg ccgtctaagc atagaagaga caatttgtct cagctgtgct 1289101 ttttttcata taaagagtaa aaataaaata atttttgaac ttgtctcata tgatgttggt 1289161 agtacaagag acaaggagag acatcatgaa tcgatttgtg aaagggatca ttcttttatc 1289221 cattgccgcc tttttcgctg aatgccttga atttgtcgtc aatatgattt tggcgcggga 1289281 gcttggcgag catgggatgg ggctttacat gagtattttg cccacgatct ttttaattat 1289341 tgtcatcgcg agcctggaac tgccgatatc catttctaaa ttcattgccg agtcaaatcc 1289401 taagcttcat gaaagcatgc tgaggcacgc tttcagaatg acagccattt ttactgcttt 1289461 ttctactgcc gccgctagta ttgcgcttcc gtttattccg gtatttgata cataccaccc 1289521 gtttattaaa gggattgtca tcggcttaat tcctgttgtc gcctttactt caatcgccag 1289581 gggctacttt atgggtgtgc agaaaatggg gaagatcgca attgccaatg tgctgaaaaa 1289641 aatcatccag ctcttgtgct tattcctctt ttttcaatgg tactcatttg aattggacat 1289701 ggctgtgctg atttccttgt ttgttctagt cgtgagtgat gtggtcgtgc ttgtttattt 1289761 atattcacaa tttatcatgg caaggcgggc gttatccggc cagcagcaca ttcatttgcg 1289821 cggaaaggat gtaaggaaaa gactgcttgc tgtttcaatt cctacaacag gactgcgtat 1289881 ttttcatgcg gttgtcaatg caattgaacc ctttttagta aaaggagctc ttttggctgc 1289941 gggcgttgcc gggacagcgg cgatcgatca atacggaatg ctggcaggag tggctgtgac 1290001 gatagggtcg ttccctgctt ttattgccca ttcgttaatg gtcgtcatga taccgagtat 1290061 ttcggaagct tatgcacttt ctcagtatga catcgtgtta aaaaggctga agcagtcgat 1290121 tttcattaca ttaggttacg gtatacctgc cgtctgggtc atgttccagt ttgcgggacc 1290181 tctcacgcat ttgttttttc actctcctga agcgcagtat tacttgcagc tgttgtggcc 1290241 ttactttctc tttcatctgt ttgtcatgcc gctgcaggcg tgcttaatcg ggatgggttt 1290301 tgtgaaagag gctttttatc acaatgtatg gagccatatc gttgcgctaa gtatgatgta 1290361 tgtactggga tcaatggaga atctgcaaat gctcgggatt atccttggaa tgaacactgg 1290421 catgattctt ttgacgagcc tgcactatgc cacgatctgc aaagcattga aggtatctgt 1290481 atttcttacg ggagggacca gaacgccgcg aattgaagga tgataaagga acagcagggg 1290541 caagctaatt gaaaagcatg aaaggaagat tccatgttga cgaagcgctt gcttactata 1290601 tacattatgt tattagggtt gattgcatgg tttccaggtg cggcacaagc tgaggaaaaa 1290661 cagcctgctg ttcccgctgt ttttcttatg aaaacgatag aaggggagga catctcgatt 1290721 ccgaataaag ggcaaaaaac aattctccat ttttggacgt catggtgccc gccctgcaaa 1290781 aaggagcttc cacagtttca atcgttttat gatgcccatc catccgacag tgtaaagctg 1290841 gtaacggtga atttagtgaa ttcggaacaa aatcagcaag tcgttgaaga ctttattaaa 1290901 gcaaacaagc tgacgtttcc gattgtcctt gactcaaaag gggaattgat gaaggagtat 1290961 catatcatca cgatcccaac atcatttttg ctgaatgaaa agggagaaat tgaaaaaaca 1291021 aaaattggcc cgatgacagc ggaacaactg aaggaatgga cggaagaata gctgagagca 1291081 tagactctca gcttttttca tatagagaag aagtgaataa acattaatga taattattat 1291141 caaaaagaaa ttaaaataat tataattgaa attctcttcg tgcgtgctat aataaaggaa 1291201 gacatcaaga aataactgac gataaagctg ccttttgggc agcgattttg tttttataag 1291261 agaaatgaag atgatttacg ttctcaatta gagaggagaa ttcgatatga atgaacaagt 1291321 tatcgttcaa cgcgacccgc atgagccatt gaaaacagac aagagggaaa aaaactgggc 1291381 acagcacgcg gagcttattg cagcacttgt atcaggcgct cttattttgg caggctggct 1291441 cttatccgga tatcaggtat tatccataat acttttcttg ctggcttttg tgatcggcgg 1291501 atttgctaaa gcgaaggaag gaatcgaaga aacactcgaa tccaaaacgc tgaatgtaga 1291561 acttttaatg attttcgctg ccattggttc cgccttgatc ggatactggg cagagggtgc 1291621 tattttaata tttatttttt ccttaagcgg agctttagaa acatacacga tgaataaaag 1291681 cagcagagat ttaacgtctt taatgcagct tgagcctgaa gaagcgacat tgatggtcaa 1291741 tggtgaaacc aaaagagttc cggtttcaga cttgcaggcc ggtgatatga ttgtgatcaa 1291801 acctggagaa cgcgtagcgg cagacggtat cattgaatcg ggctcgacaa gtcttgacga 1291861 gtcggcttta acaggtgaat caatgcctgt agaaaaaaac acaggcgaca ctgtattcac 1291921 aggaacggtg aatcgcaatg gctccttgac agtccgtgtc acgaaagcaa atgaagattc 1291981 gttattcaga aaaattatca aactggttga atcagcgcaa aatagtgttt cacccgcgca 1292041 ggctttcatc gaacgatttg aaaatgctta tgtgaaaggt gtgctaattg cggtggcgct 1292101 ccttttattc gtcccgcact ttgcgctggg ctggagctgg agtgaaacct tctaccgcgc 1292161 aatggtgttt atggttgtcg cgtcaccttg tgcgcttgtc gcctctatta tgccggcggc 1292221 gctgtccctg atttcaaatg gcgcccgcaa cggtatgctt gtgaaaggaa gcgtctttct 1292281 tgaacagctg ggctcagtgc aaatgatcgc ctttgataaa accggaactg taacaaaagg 1292341 ccagcctgcc gtagagacga tcagaatagc agaaggattc agtgaagcgg aagttcttga 1292401 ggctgtctat gccatcgaaa cgcaatcaag ccatccgctc gcccaagcca taacggcgta 1292461 cgctgaaagc cgcggcgtga atcagtccgg ctacatatct atagaagaaa cctcagggtt 1292521 tggcgttatg gcagaagtgt cgggtgcgaa atggaaggtc ggtaaagcag gttttatcgg 1292581 cgaggaaatg gcagcacaat ttatgaaaca aacagcatca gatgtcattc aaagcggtca 1292641 tacaattgta tttgtgaaaa aggatgatca aatagcaggc tgtatcgcac tgaaggacca 1292701 aatcaggcct gaagcaaaag aggtcatgga agaactgaac cgacttggga ttaaaacggc 1292761 catgctgaca ggagatcacg aagacacggc tcaagcgatt gccaaggaag ccggcatgac 1292821 aactgtcgtg gcagaatgcc tgcctgacca aaaagtgaat gaaatcaaac ggttaaaaga 1292881 agaattcgga acgattgcaa tggtgggtga cggaatcaat gatgcgccgg cactcaaagc 1292941 agcggatgtc ggcattgcga tgggcggcgg aacagatgta gcacttgaga ccgctgatat 1293001 ggtcctcatg aaaaacgatt tgaaaaagct cgtaaacatg tgccgcttgt ctcggaaaat 1293061 gaacaggatc atcaaacaaa atatcgtgtt ttctctagct gtaatctgcc tgctgatttg 1293121 tgcaaacttt ttgcaggcga tggaattgcc atttggcgtg attggtcatg agggcagcac 1293181 gattttagtc atactaaacg gtttaagact cctaaaataa aaccagcagc ctaatcaggc 1293241 tgctggcttt ttatgtatca agctttccct tcatttttgt ctttatcaga tcttttcata 1293301 actaggatga gagcgagggt gcagcaaagg aaacccgctg cacagcctat gatagagctg 1293361 taataataaa agcccaccat cttcatcccg ataaaaggag cggaaattcc caaaaccgtt 1293421 aagagcataa ctgcttttcg tctgaaaaaa ttcatcagca aacggaacaa cccccctgcg 1293481 attgaacgtt actgtcagta tacaggaaga ggagcaggaa ataaaatgca ttagaaaatg 1293541 aaggcgtcgt gaaaggcaaa caccggtaaa acctgttaca atggaagaca gaacaatgca 1293601 ttgcaaatgg cagggaggaa caagaagtga atagaataca acgcgtctct tcatggctga 1293661 aggaagcggg gcatactgcc gcatttattc atacgaaaga aaatgttttt tacttaaccg 1293721 gtttttacac agagccgcat gaaagattaa tggggttatt tatttttcaa gaagaggagc 1293781 ctttctttgt ttgtccagga atggaagcag gacaggcccg caacgcaggc tggaatcatg 1293841 aaatcattgg ctatgcggat cacgaaaatc cgtgggagct gatagagaag gctttgaaaa 1293901 agcgaaatat cagcatacat atgcttgcgg tagaaaagga ttcaatctcg ctgtcacgtg 1293961 cagaacagct gaagcatgcg acgggcgggg ctcaatttgt ttcagcagaa gaaacactca 1294021 atcaatttcg cctgattaaa gatgacaatg agattcgttt gctgaaagag gcggcaaagc 1294081 ttgcagatta cggtgttgaa gtcggcacag ccgctttgcg tgaaggcatc agtgaagtgg 1294141 aagtgctcgc tcaaattgag tatgagctga agaaaaaagg aattcagggc atgtctttct 1294201 ctacaatggt tttattcgga gaaaaatctg gccagcctca tggaaatcct ggtacagcca 1294261 cgttgaagaa aggtgatttt gttttatttg atctcggtgt tattcttgat ggctattgct 1294321 ctgatattac aagaacgttt gcatacaaaa ccatcaatcc gaagcaggag gccatttacg 1294381 agactgtgct tcaagcggaa aaagccgcga ttgaggcaag caaacccggt gtgagaatcg 1294441 gagatctgga tttaactgcc cgcggaatca ttgaaaaagc gggatatggt gattattttc 1294501 ctcaccggct tgggcatgga ctcggaattt cagtccatga gtatccatca atgagccagg 1294561 ccaacgatac actgctgcag gaaggcatgg tctacacgat cgaaccgggg atttatgtgc 1294621 cagagatcgg cggcgtacgc attgaggatg acgttcacgt aacaaaggac ggagcagttg 1294681 ctctgaccca atatccaaag gatttgatca tactgtaata gaaataaaaa aggactttgt 1294741 tctcgacatc gtcctttttt atctgcatta aataaaaaaa tcatcaaatg ttcgaaaggg 1294801 tttaatttca tgtttttggt tgagaggttt tacagcaaga cagctgccac cgagaacagt 1294861 gagacataac ccaattaaaa tgaagaaacc catgtgatct tctcctttca gctaaaaaca 1294921 caaaaagata tctggtacgt ccatatcata ttgtatgaaa cgcattccag atcaagggga 1294981 tttagaaaga agggaatcta tggctaatat taaagacatt gcagagaaag ccggtgtctc 1295041 tgttacaacg gtttcccgag tcataaacaa tcatccatac gtcagtgaag acaaacgaaa 1295101 aagagtgttt gaggcaatgg aatcattgga gtacacgaga aatattcacg ctgtacattt 1295161 gtcgaaagga ttttcaaaca tgattggtgt tgtcttgccg acggttaatc tgccatattt 1295221 tgcagagctg attgcaggaa tagccgacgc agccgcggaa tccggggttc acctctcttt 1295281 attccaaaca aactatgaag tacaaaaaga aatctttgcg ctgtcccaat taaagcagcg 1295341 ccaggttgac ggcctgattt tttgctcaaa ggcgcttgct gatgagaaac tcatggaatg 1295401 ggagggcccg attttgcttt gccagaattc agataatgcc cgcttcccaa ccatcagcat 1295461 tcctcaccaa gaagcatttc ggaacggctt ggactattta attgccaaag ggcacaaaaa 1295521 aatagccatc tgtttggcaa gaaaaaaagg catgaacagc cattttcgaa tcaaagccta 1295581 caaagaggca ttggaagaga tcggcgaggc atttcgtgaa gactgggtaa ttgagaaagc 1295641 gattacaatc aatgatggga aggcgctttt tcataaatgg aatacgtgga aggaaaagcc 1295701 gacggctatt tttgttgcca atgaccaagt ctcagcaggg ctttttcttg aagcaaagaa 1295761 ccagcgggtg tcagtaccgg atgagcttgc aatcttaagc gttgataacc acgaaatcag 1295821 ccaagcgctt ggaatcacaa cgatcgatat tcagacaagg gaaatgggaa agcaggcatt 1295881 tgccatattg gaaaaaagaa ttcaaggaca gccgattgaa aggaaagttc tggattaccg 1295941 tctcatcgaa agatcgactg tttagtgaat gcattgaaaa aaggtttgac gtgcattctg 1296001 ttcgttatgt acgatatgag gtattgaatg acaaaggagc tgaggatcgt gaatgggtcc 1296061 ttcacagtga aaaaggtact gaataataac gtattaattg cttctcatca taaatacagc 1296121 gaagtcgttt taatcggaaa aggtattggt ttcggaaaaa aacaagatga tgtcattgaa 1296181 gataaaggct acgataaaat gttcatttta aaagacgaga aggaacaaaa gcagtttaaa 1296241 aagctccttg actatgttga tgaaaagctc gttgatattt caaacgatgt catctatcac 1296301 ataagcaata ggacgaatca ctcattaaat gaacatattc acattgcgtt gacagaccat 1296361 atcgcatttg cgatcaaaag gcagcagcag ggatttgata tgaaaaatcc atttctaatg 1296421 gagactcagt cactatatcc tgaggagtac caaattgcca aagaagtcat agatatgatc 1296481 aatgaaaaag cgggactctg ccttccggaa ggggagattg gttttatcgc tctgcatatc 1296541 cattcagcgt tgacaaaccg tccgctgtcc gaggtcaatc agcactctca gctcatggcg 1296601 cagcttgtcg aggtgattga agactcattt caaatgaaag taaataagga aagtgtcaac 1296661 tatttgcggc tgatcaggca tatcagattt acaatagaaa gaattaaaaa agaagaaccg 1296721 actaaagaac cagaaaaatt aatgttgtta ttgaaaaatg aatatccgct atgctacaat 1296781 acagcttgga aattgattaa aatcttgcag caaacattga agaaaccagt tcatgaggcg 1296841 gaagcggttt atctgacgct tcatctgtac cgattaacca ataaaatttc ataaattcag 1296901 tttatcctta taacgtgtta ctgattcgat caggcatgag tgattgaggg aaaaaaacgg 1296961 gaagttcatt ctcgttcttt tgcgcaccca attttgctca tgcctttttg ttgtgtaaaa 1297021 gggcaaatgt aaacggttaa actggaagac ttacgcctgt gaattcgttg tcatgatttt 1297081 tagctgtaag gtcagactag taaaaagagg aggtcaattc ttatgtttaa agcattattc 1297141 ggcgttcttc aaaaaattgg gcgtgcgctt atgcttccag ttgcgatcct tccggctgcg 1297201 ggtattttgc ttgcgatcgg gaatgcgatg caaaataagg acatgattca ggtcctgcat 1297261 ttcttgagca atgacaatgt tcagcttgta gcaggtgtga tggaaagtgc tgggcagatt 1297321 gttttcgata accttccgct tcttttcgca gtaggtgtag ccatcgggct tgccaatggt 1297381 gatggagttg cagggattgc agcaattatc ggttatcttg taatgaatgt atccatgagt 1297441 gcggttcttc ttgcaaacgg aaccattcct tcggattcag ttgaaagagc caagttcttt 1297501 acggaaaacc atcctgcata tgtaaacatg cttggtatac ctaccttggc gacaggggtg 1297561 ttcggcggta ttatcgtcgg tgtgttagct gcattattgt ttaacagatt ttacacaatt 1297621 gaactgccgc aataccttgg tttctttgcg ggtaaacgtt tcgttccaat tgttacgtca 1297681 atttctgcac tgattctggg tcttattatg ttagtgatct ggcctccaat ccagcatgga 1297741 ttgaatgcct tttcaacagg attagtggaa gcgaatccaa cccttgctgc atttatcttc 1297801 ggggtgattg aacgttcgct tatcccattc ggattgcacc atattttcta ttcaccgttc 1297861 tggtatgaat tcttcagcta taagagtgca gcaggagaaa tcatccgcgg ggatcagcgt 1297921 atctttatgg cgcagattaa agacggcgta cagttaacgg caggtacgtt catgacaggt 1297981 aaatatccat ttatgatgtt cggtctgcct gctgcggcgc ttgccattta tcatgaagca 1298041 aaaccgcaaa acaaaaaact cgttgcaggt attatgggtt cagcggcctt gacatctttc 1298101 ttaacgggga tcacagagcc attggaattt tctttcttat tcgttgctcc agtcctgttt 1298161 gcgattcact gtttgtttgc gggactttca ttcatggtca tgcagctgtt gaatgttaag 1298221 attggtatga cattctccgg cggtttaatt gactacttcc tattcggtat tttaccaaac 1298281 cggacggcat ggtggcttgt catccctgtc ggcttagggt tagcggtcat ttactacttt 1298341 ggattccgat ttgccatccg caaatttaat ctgaaaacac ctggacgcga ggatgctgcg 1298401 gaagaaacag cagcacctgg gaaaacaggt gaagcaggag atcttcctta tgagattctg 1298461 caggcaatgg gtgaccagga aaacatcaaa caccttgatg cttgtatcac tcgtctgcgt 1298521 gtgactgtaa acgatcagaa aaaggttgat aaagaccgtc tgaaacagct tggcgcttcc 1298581 ggagtgctgg aagtcggcaa caacattcag gctattttcg gaccgcgttc tgacgggtta 1298641 aaaacacaaa tgcaagacat tattgcggga cgcaagccta gacctgagcc gaaaacatct 1298701 gctcaagagg aagtaggcca gcaggttgag gaagtgattg cagaaccgct gcaaaatgaa 1298761 atcggcgagg aagttttcgt ttctccgatt accggggaaa ttcacccaat tacggatgtt 1298821 cctgaccaag tcttctcagg gaaaatgatg ggtgacggtt ttgcgattct cccttctgaa 1298881 ggaattgtcg tatcaccggt tcgcggaaaa attctcaatg tgttcccgac aaaacatgcg 1298941 atcggcctgc aatccgacgg cggaagagaa attttaatcc actttggtat tgataccgtc 1299001 agcctgaagg gcgaaggatt tacgtctttc gtatcagaag gagaccgcgt tgagcctgga 1299061 caaaaacttc ttgaagttga tctggatgca gtcaaaccga atgtaccatc tctcatgaca 1299121 ccgattgtat ttacaaacct tgctgaagga gaaacagtca gcattaaagc aagcggttca 1299181 gtcaacagag aacaagaaga tattgtgaag attgaaaaat aagggtgtta gtacgccgtg 1299241 cttgtcagat gacaagtacg gttgtatgat ataatattgt gaagtaataa agctttaagt 1299301 taaaaggaga atgataaaaa tggcacaaaa aacatttaaa gtaactgcag attctggaat 1299361 ccatgctcgt cctgcgacag ttcttgtaca aactgctagc aaatacgacg ctgacgttaa 1299421 tttagaatat aacggcaaaa cagttaacct taaatctatt atgggtgtta tgtctttagg 1299481 tatcgctaaa ggcgctgaga tcacaatctc tgcttccgga gctgacgaaa acgatgctct 1299541 taacgcttta gaagaaacaa tgaaaagcga aggactcggc gagtaatgca agaattaaaa 1299601 gggattggtg cttcagccgg catcgcgatt gcaaaagcgt accggcttga agagccagat 1299661 ttaacggttg aaaagaaaaa catctctgat tctgaagcgg aagtaagccg ttttgatgaa 1299721 gcgattgcac gttcaaaaga agagctcgaa aaaatcaaag agcacgcttt gaaagaactg 1299781 ggtcaggata aagctgatat tttttctgct caccttttag ttctcagtga ccctgagctt 1299841 ctgaaccctg tgaaagaaaa aatcagcact gattcagtga acgctgaatt cgctttaaaa 1299901 gaaacgtctt ctatgttcgt tactatgttt gaatctatgg acaacgaata tatgaaagag 1299961 cgtgcggcag atatccgcga tgtaacaaaa cgcgtaaccg gccacctgct tggcgtcgaa 1300021 attccaaacc caagcatgat ctcagaagag gttattattg tagctgaaga cttaacaccg 1300081 tctgacacag ctcaattaaa ccgtgagttc gtaaaaggat tcactactga tatcggcgga 1300141 cgcacatctc actctgccat catggcacgt tctcttgaga ttccagcagt tgttggaacg 1300201 aaagctgcta caggcacgat ccaaaacggc gtgactgtta tcgttgacgg tatcaatggc 1300261 gatgtcatta ttgacccatc tgcggaaact gtaaaagagt atgaagaaaa acataatgct 1300321 tatttggctc aaaaagctga gtgggcgaag cttgtcaatg aaccgactgt ctcaaaagac 1300381 ggacatcatg tagagcttgc agcgaacatc ggtactcctg atgatgtaaa aggtgttctt 1300441 gaaaacggcg gagaagcagt tggcctttac cgtacagaat tcctttacat gggaagagat 1300501 cagctgccta cagaagatga gcagtttgat gcttacaaaa cggttcttga gcgtatggaa 1300561 ggaaaatcag tcgtcgtgcg gacacttgat atcggcggag acaaagagct tccttacctg 1300621 cagcttccta aagaaatgaa cccgttcctg ggatatagag cgattcgtct ttgccttgaa 1300681 gagcaagaaa tcttcagaac acagcttcgc gcgctgcttc gtgcaagtac atacggaaac 1300741 ttgaaaatca tgttccctat gattgcgaca gttaacgaat tcaaagaagc aaaagcgatc 1300801 cttcttgaag agaaagaaaa gctcgtaaaa gcgggacagg ctgtatctga cgatattgaa 1300861 gtcggaatga tggttgagat tccgtcaact gcagtcatcg ctgatcagtt tgctaaagag 1300921 gttgatttct tcagtatcgg aacaaacgat ttgattcaat acacaatggc agctgaccgt 1300981 atgaatgaac gtgtatctta cctgtatcag ccatacaacc cggcaatcct tcgcttaatt 1301041 acactggtaa ttgaagcagc acacaaagaa ggaaaatggg ttggcatgtg cggagaaatg 1301101 gcaggagacg agattgcgat tccgatcctt ctcggcttag gcttagatga gttctcaatg 1301161 agcgcaacgt ctatccttcc ggcaagaaca caaatcagca aattgtctaa acaagaagct 1301221 gagtcattca aagagaaaat cttatctatg agcacgacag aagaagttgt cgcgttcgta 1301281 aaagaaacat tcaagtaatg tacaaaaacc agacggcctc cggcctgtct ggtttttttc 1301341 ataagtaagg gtatagaagg acacaataac atggctagga gggatagtat gtcaaaccaa 1301401 tttaacgcag gagatactgt ttatgtgatc tacagaaatc cgcacgccgc caatgtagcc 1301461 cacataaagg aagccgaaat tgtgcaccat ccataccatg aaggcgagct ttccctgttt 1301521 atttatgaaa cctatcatcc attcgcagag gacgatgctg tgtttgcaag ctatgaagaa 1301581 gctaaatcgc tttacaaaga actgtttgat attgatccgt atgagtaaca aggaaatcat 1301641 tacaactcat atcctttccg cctagtgaga aaagtaacgt tagtaaagga aaaggatgtg 1301701 gcatcatgca gaacccattt gttccgcagc ttgtgtatat agaaccgagg gcgctggaat 1301761 atccgctggg ccaagaatta caagataaat ttgagaatat gggtattgaa atcagagaaa 1301821 cgacatccca caatcaggtg cgtaatatcc ctgggaaaaa tcatcttcag caatatcgca 1301881 atgcgaaatc aactttagtt atcggtgtcc ggaaaacatt aaagtttgat tcatccaaac 1301941 cctcggccga atatgccatt ccgtttgcaa caggctgcat ggggcattgt cattactgct 1302001 acctgcaaac aaccatggga tcaaagccgt atatcagaac ttatgtaaac gtcgaagaga 1302061 ttttagatca ggcagataag tatatgaagg agcgcgcacc agagttcaca aggttcgaag 1302121 catcatgtac gtcagacatt gtaggaattg atcatctgac acacacgctg aagcgcgcca 1302181 ttgaacattt tggccaaagt gatctcggaa agctccgatt tgtaacgaaa tttcatcatg 1302241 tcgatcacct attagacgca aagcataacg ggaaaacgag attcagattc agtattaatg 1302301 ccgactatgt gattaaaaac tttgagccgg gaacttcacc tcttgataag cggatagaag 1302361 cggcagtaaa agttgcaaaa gcaggctacc cgctaggctt tattgttgct ccgatttata 1302421 ttcatgaagg ctgggaagaa ggatacagac atctgtttga aaagctagat gctgctttgc 1302481 cgcaggacgt tagacatgac attacgtttg aattaattca acaccgtttt acaaaaccgg 1302541 ccaaacgagt gatagagaaa aattatccga agacgaagct cgaattagat gaagaaaagc 1302601 gccgttataa atggggccgt tacgggatcg gaaaatatat ttatcagaaa gatgaagagc 1302661 atgcacttcg agaggcactt gaatcctata ttgatacctt tttccctaac gcaaaaattg 1302721 aatatttcac ttaaacgggc tgttgtgatc aacagctcgc ttttttataa aaaacatttt 1302781 tccattccat caaaacgccg taattcaatg attctttatc ctccaaataa ttgctgacta 1302841 cacgaatagg tgaacgcccg caacggagga gaaaggacag cacagggtcg tttttcctgc 1302901 cttccatcac atcttcaacg tactgaacag cgctgatctc gtgtgcgtat ttataataca 1302961 aaggaatgcg gccgccgccg agaaggcgtt ccagtctttt atcaacagtc agctcataca 1303021 tcgtattcat cagccatttt ccgattccaa gctttcgata atgaggagaa acagaaatat 1303081 ccactacata taaagtattt ccatgaggtt catgattttt aatcgatccg ttgtcagttg 1303141 cttgtgccca tgtatgatca ggagaatcag gctcaaattg tacaataaga gcagtcatgg 1303201 aaccgataat tctgccattg atgagcgcgc ataaagcgcc ttccggaaag gttttgatat 1303261 ggctggcaag ctggtcctct gaccacagca attcctgggg aaacggagga gggaaacatt 1303321 cttcttgaag agaaatcagc ctctcgatgt cagtctcagt gtagtttcta atggtcagag 1303381 cctcaaattt tctgccgtca tgcacataca tttgttttag tatgatcatc actctcctta 1303441 tgttgtttca ttataacgaa gattgaattt tcagtaaata tattccgatt ttcttataat 1303501 ttattttttg attattcatt tttcaaacga aagggccgat atagaaatta ggaggggatt 1303561 ggtttgttta aaaaacttca catgaagatt gctgtttttg tttcgattat gttaatcatc 1303621 acagttgttc tcttaatgct gtcttcttat ttgacgctaa aaccgatgat tacagaggat 1303681 gggaaaaata caactcaaaa cgtgacgcag tcacttgaac aaaatattga attgcaatta 1303741 aagagttatg ccatttcgtt atcaagattg gctaatgggg aattaacgca tacatttgta 1303801 acgaaaccaa gtaaagaagc ttctcggctg tttcacgatg acattaagca aatcaaagac 1303861 aacgatgatt atgttgcgat ggcttacata ggcaccgcaa aaaaagaaat gtttacatat 1303921 ccaaaagcgg atttcgctga ggattacgat ccaacatcaa gaccatggta taagcttgca 1303981 gctgaaaccc cggatcaagt tgtttggacg gaaccttata aagatgtcgt gacaggagac 1304041 atgattgtta ctgcatcgaa agcgatctta gacaggcaaa aagtgatagg ggttgccagc 1304101 tatgacttga aactctctgc tatccagagt atggtcaata aacaaaaggt gccttacaaa 1304161 ggatttgcct ttttagctga tgcgagcggc aatcttttag cccatccgtc aaatcaagga 1304221 aaaaatatat caaaggatca aacactgcaa accatcgcat ccgagaaaaa agggatacaa 1304281 gatgtgaatg ggaaaatggt tgtgtaccaa acgattggcg agacaggctg gaaggtcgga 1304341 acgcaatttg ataccgatca attaatgtgg atttcagata aaatgaatcg ggccaatctt 1304401 tggatatcat tgattgcgct tatcataaca attattctca gctacttcct ggccaaaacg 1304461 ataaccggtc cgatacagca gctgatcgta aaaacgaaag ctgtttccgc aggcgattta 1304521 acagtgcgcg cggaatcaaa atctaaggat gaagtcggta ttttaacaag agatttcaat 1304581 ctgatggttg aaaatatgaa ggaaatggtt gagcaagtga gactctcttc agggaaagta 1304641 tctgacacct ctgaacaact aacggctgtg gctgccgaaa ctaatgaaac aagcggacaa 1304701 attgcaaaag cgattgaaga agtagccgca ggggcatcgg aacaggcttc tgaagttgaa 1304761 accattaatg aaaaatcgga aagcctgtca acgaaaatca ggcaaatcgc tgaggaggca 1304821 ggcggaatta aagaacgctc aaaatcgtcc gaggatgcaa gctataaagg acttgacgcg 1304881 ctcggccagc tgctgatgaa atcaaacgaa gccaatatgg aaacgaaaaa ggttgaaacg 1304941 atgctgctgg atttggaaaa tcaaactaag aatattgaag aagtcgttac agcgatttca 1305001 aacatatctg atcaaaccaa cttgcttgcc ttaaatgcca gtattgaggc agccagagcc 1305061 ggagaaagcg ggcgcggttt tgccgtcgta gccgatgaag tgcggaagtt agctgagcaa 1305121 tcagcccttt ctacaaagca tatcagcgag actgtgaagc ttatccagct tgagacaaaa 1305181 gaggcctctc acgcgatggt tgaggcaagc agaatgaatg atgaacaaaa cagtgcaatt 1305241 cacgaaactg gagaggtatt aaatacgata actgcagaaa tgcagtcact ggtacaaggt 1305301 attgatcaca tttacgcgga aattcaaaga atgagtgaag aacagcttgc gatttctgaa 1305361 gccattcaaa gcatttcagc catatcacag gaatcagctg ccgcagcaga ggaagtgaac 1305421 gcatcaaccg atgaacagct tgtcaccctt gataaagtca aacactcaac ggaaacacta 1305481 aaacatgcaa gccaagagct tatgaacaca attgcaaaat tcacattgta atccaattac 1305541 atccccaaac atcatttgtt ttggggattt tttattttat aagatgaata gatatggtag 1305601 tctagaaaat gaaggaaaaa tgataaattt taactaaaat ctaaacgaaa catctgggag 1305661 gaatgacctt gaaaaaaaca attggtttta tcggtcttgg agtaatggga aaaagcatgg 1305721 catcacatat tctcaatgac ggccatcctg tattggtgta cacccggaca aaagaaaaag 1305781 cagaaagcat acttcaaaaa ggcgcgatct ggaaagatac ggtcaaagat ctttcgaaag 1305841 aagcggatgt tatcatcaca atggtcggct atcccagtga tgttgaagaa gtgtatttcg 1305901 gaagcaatgg aattattgaa aacgcaaaag aaggtgcata tcttattgat atgacgacat 1305961 ctaagccttc gcttgcgaag aagattgctg aagcggccaa agaaaaagca ttgttcgctt 1306021 tagacgctcc tgtttccggt ggagacatcg gtgcacaaaa cggaacactc gcgattatgg 1306081 tcggtggaga aaaagaagct tttgaagcct gcatgccgat tttctcttta atgggagaga 1306141 atattcagta tcaaggaccg gctggaagcg gacagcatac caagatgtgc aatcagattg 1306201 caattgcagc cggtatgatc ggtgttgctg aagcgatggc ttatgcccaa aaatcaggcc 1306261 tagagccgga aaatgttctg aaaagcatca caacgggcgc agccggaagc tggtcattgt 1306321 caaatcttgc tccccgtatg ctgcaaggca actttgaacc gggattttat gtgaagcatt 1306381 ttattaagga tatgggaatt gcactagagg aagcagaatt aatgggggaa gaaatgccag 1306441 gcttgtcgct cgcaaaatct ttatatgaca agctagctgc tcaaggtgaa gaaaacagcg 1306501 gaacacagag tatatataag ctttgggtga aataaaaaaa gattgcctgt acgaaacagg 1306561 caatcttttt ttattatttt ccgatgaatt gttgtgtcca gatgcttcca gactcaacgt 1306621 aaccaacacc gatgtgagta aagttagggt ttagaatgtt ttttctgtgt ccttcactgt 1306681 tcatccaagc ttttactact tcttctggtg tcttttggcc cttcgcaatg ttttcacctg 1306741 ctgttttgta gctgattccg aaagatttca tcatatcaaa cggtgagccg tatgttgggc 1306801 tttggtgatc aaagtagttt ttgtctttca tatcctgaga ttttgcgcgt gcagatttgc 1306861 ttaacgtttc atcaatttga agcggtttta agccttgttt ttgtctttct gcatttgtaa 1306921 gttcaacaac ttttttctca tatgcactta cagatgaagg tgcagacgtt gttgtgtttg 1306981 ttttttcagc agttgcgggt gctttagaag cagtgttttg atcagcagct gctttttcag 1307041 tagtcttttg tgcaggtttt gccgtttctg tcttttgaac atcctgaact ttcacgttag 1307101 attgcttcgc atgtttttga agaagctgct tcatctcttt ttcgtttgca gcgtttaacg 1307161 ttttgatatt tgtgttaata tgcagttttt tcactgcatc gttaagtgac atgttttgta 1307221 ctgtgttccc cgtttttact gtaaccacag gctggcagga gagttctttc gctgatgctt 1307281 gctgtacgcc cccgaatgtg aataatccaa ccgcagcggc agcagataaa ataaatgctt 1307341 tcttcattag ttcgtaacct cctagagttg tttgtttcta cagaaaaatc ataacatagc 1307401 ttttttgtca taaagattcc agcactttcc tttgacaaat agagattgtc attttcgtaa 1307461 agtaaatccg ttgaatcact aagaataagg gaatcagcgg tatatatgat tttatcgtac 1307521 cgttacatag cttccttttt tttgaaccgt tagttatatt ttaatgtgtt tttatattga 1307581 cagctttttt tactcctttt cgctgtaaca actattacaa aggtgttaca attaatctca 1307641 gtatatgtaa atatattgaa tgatttgaga ggggtaacca gaagtgactg aaataggacg 1307701 tgaaccaaag aaaaagagca aaggaaacag agcaatcaga atgaaccttt ttttcctagc 1307761 tgtctttgtt ctattcactg cattaatttt taagctcggg gttgttcaaa ttgttgaagg 1307821 cgaacagcat gaagaagacg ctgagaaatc aaatgcaaaa acagcttact atcctgcgcc 1307881 tcgcgggaag atgtacgaca gaaaccagaa agttgctgtc gacaaccaga gcgttccaga 1307941 aattgtgtat gtatcaacat ctagcacaaa aacagaagat aaaatcaaaa cagcgaagcg 1308001 gcttgcttct ttcattcata ttgataccga atttttgaag gaaagggatc ttcgtgatta 1308061 ctggatcgca gctcatccga aaaaagccgc cgctctgctt aaggaatcag aaagcaatct 1308121 gaaaggagac caggcttaca agcttcaaat agagcgtgtt ccggatcaag aattaaaggc 1308181 tattcagcaa gatgacgaag aaatggaaac tgctgcgata tatacaaggt tttcaagcgg 1308241 aaatgcttac gaacctcaaa tcgtaaaggc aatgaatcca aataagagca atagcaatgg 1308301 aaaaaacgga gcgctgcttg atgagaagaa aaactcctcg caaagaccaa aaaatgactt 1308361 aacatatgat gaaatttcca ttgtttctga gcatttagaa gaacttccgg gaatcgatat 1308421 cgtaaacgat tggacacgaa aatatcctta tgacaaaacc ctttattctg ttttcggggg 1308481 cgtcacgaca cctgatcagg gcctgctgag cgaccggaaa gatttctact taacaagagg 1308541 ctatgcgaat aatgacaggg tgggaaaaag ttatttagag tatcaatatg aagaatattt 1308601 aaattcgcat aaagaaaaag tggaatacgt agaagataat aaaggaaatg tcgtcagcca 1308661 aaaaaccatt gataagggca gcaggggata cgatcttcag ctttcttttg acatggagct 1308721 tcaggcaaag gtagaaaaga tcattgaaga agaagtaaga aacagccgtg cacgcggaaa 1308781 ttacatgctt gacagagcct ttgccgtaat gatggacccg aataacggcg atattttatc 1308841 aatggcaggg aaaaagatag atttaaaaac caacaaaatt gaagattatg cgataggggc 1308901 atttaccacc caatatgaaa tgggatcagc agtaaagggg gccaccgtgc tagccggcta 1308961 tcaggacggg atcccgcatt ataaatatta tatcgatgct ccaatgcttt taggaacgaa 1309021 tcttataaaa aaatcttata ctaatatggg aaccatcaat gaattaaccg cattgcaaaa 1309081 aagttcaaac gtatatatgt tcaatgttgc catgcatatt gcaggcgtaa catacaagcc 1309141 gcatggatct ctcccggctg atcagaacga tctactgaaa atgagaaact attacagcca 1309201 gtttggtctg ggagtaaaga caggtattga tctcccgcag gaatcagccg gaatgcaaac 1309261 cacacctaaa actgtaggag gattaatttt agacttagca attggccaat acgatacata 1309321 cacaccgctt caaatggctc aatacatctc agtaatcgcc aatggtggct atcgtgttca 1309381 gcctagaatc gtcacaagta ttcataagcc aggaaaaaaa gaccagctgg gtaaggcgat 1309441 tgaacatagg aaacctaaag tactcaataa gattaataat tcagagagcg atttgaaaca 1309501 agtacaaaca ggcatgaaat tagtcacttc ttcagggaca gcaaaaaata cgtttacaga 1309561 agatgtatca gggaaaacgg gaacagcgga aacattttac tacggcacga atcgcaactg 1309621 gtgggggaaa aaaacataca atctgacttt tgtcggctat tacccgtcga aaaaaccaaa 1309681 agtggccttt agtgttgttg ttccatcagt agatgatgat gataagatca ataaaattat 1309741 tgccaaaaga gctatccacg cctacgcaga gctcgaaaaa aaacacagta aaaaataaaa 1309801 aacagggtgc acaactaaaa gattgtgtgc cctttctttt attcaaaaat tgacgttcac 1309861 cataagaata gaaggagaat actcattttc tagcgaatca tactaggtaa aagtcaatct 1309921 gtatatgtcg aaacacgatg atcatgcaaa ggagggattc tgtggaacag gatacgcagc 1309981 atgttaaacc acttcaaaca aaaaccgata ttcatgcagt cttggcctct aatggacgca 1310041 tcatttatat atctgccaac tccaaactgc atttgggcta tctccaagga gagatgatcg 1310101 gatcattcct caaaacgttt ctgcatgagg aagaccaatt tttggttgaa agctattttt 1310161 ataatgaaca tcatctgatg ccgtgcacct ttcgttttat taaaaaagat catacgattg 1310221 tgtgggtgga ggctgcggta gaaattgtta cgacaagagc tgagcggaca gaacgggaaa 1310281 tcattttgaa aatgaaggtt cttgaagaag aaacaggcca tcaatcccta aactgcgaaa 1310341 aacatgaaat cgaacctgca agcccggaat cgactacata tataacggat gattatgaac 1310401 ggttggttga aaatctcccg agtccgctat gcatcagtgt caaaggcaag atcgtctatg 1310461 taaacagcgc gatgctttca atgctgggag ccaaaagcaa ggatgctatt attggtaaat 1310521 cgtcctatga atttattgaa gaagaatatc atgatatcgt gaaaaacagg attatacgaa 1310581 tgcaaaaagg aatggaagtc ggaatgattg aacagacgtg gaaaaggctt gatggcacac 1310641 ctgttcattt agaagtgaaa gcatccccga ccgtctacaa aaaccagcag gctgagctgc 1310701 tgctgctgat cgatatctct tcaaggaaaa aattccaaac catcctgcaa aaaagccgtg 1310761 aacgatatca gctgctgatt caaaattcca ttgataccat tgcggtgatt cacaatggaa 1310821 aatgggtatt tatgaatgaa tcgggaattt ccctgtttga agcggctaca tatgaggatt 1310881 taattggcaa aaacatatac gatcagctgc atccttgcga tcacgaggat gtaaaagaga 1310941 gaatccaaaa cattgccgag caaaaaacag aatctgaaat tgtcaagcaa tcctggttca 1311001 cctttcagaa cagggtcatc tatacggaga tggtctgcat tccgacgacc ttttttggtg 1311061 aagcggccgt ccaggtcatt cttcgggaca tctcagagag aaaacaaaca gaagaattga 1311121 tgctgaaatc ggaaaaatta tcaatcgcag ggcagctcgc ggcgggaatc gcccatgaga 1311181 tccgcaaccc tcttacagcg atcaaaggat ttttacagct gatgaaaccg acaatggaag 1311241 gcaacgaaca ttactttgat attgtgtttt ctgaactcag ccgtatcgaa ttaatactca 1311301 gtgaactgct catgctggcg aaacctcagc aaaatgctgt caaagaatat ttgaacttga 1311361 aaaaattaat tggtgaggtt tcagccctgt tagaaacgca ggcgaattta aatggcattt 1311421 ttatcagaac aagttatgaa aaagacagca tttatataaa cggggatcaa aaccaattaa 1311481 agcaggtatt cattaattta atcaaaaatg cagttgaatc aatgcctgat gggggaacag 1311541 tagacattat cataaccgaa gatgagcatt ctgttcatgt tactgtcaaa gacgaagggg 1311601 aaggtatacc tgaaaaggta ctaaaccgga ttggagagcc atttttaaca acaaaagaaa 1311661 aaggtacggg gcttggatta atggtgacat ttaatatcat tgaaaaccat cagggagtta 1311721 tacatgtgga cagccatcct gaaaaaggca cagcgtttaa aatttcattt ccaaaaaaat 1311781 aaaaacaacg gcttaaacgc cgttgtttat cgtctgcatt gcttcacgtt tttttaatac 1311841 aaataattct aaacggtcta ggccttctct cagcgtgtcc attgagcatg caaaagacag 1311901 ccttacatat ccttcaccat atgttgagaa cgagctgccc ggcacgagtg ccacgccagc 1311961 gtcttccaaa agagccatac taaaatcaaa tgaagtcatt ccaaatgatt taatagaagg 1312021 gaagatataa aacgcaccgg acggtttaac tacgtcaagt cccatggaaa caagacggtc 1312081 ataaacatag tccagacgtt ttttgtattg ttctctcata atcaatgcat cgtcaaagcc 1312141 gtttgtgaca gcttcaagcg cggctttttg agaaatggat gaggcgcacg acacattgta 1312201 ttgatgaacc tttaaaatgt gctttgcaat gtctttcggt gcaaataaaa atccaattct 1312261 ccaaccggtc atgctgtgtg attttgacaa cccgttaatg acaatcgttt gatcccgcaa 1312321 ataggttgcg atggagtaat gcggtctgtc atatgttaat tcactgtata tttcatcaga 1312381 caatacgaag acatttctgc cttttaagag agctgcgatg cttttcagtt cttcttcaga 1312441 taaagtcacg ccggtagggt ttgacggata aggaagcacg acacacttgg tgttgggtgt 1312501 cagagcatct tcaatcagcc gggcggtaag cttaaagccg tgtgacgtag tatcaacaat 1312561 gacaggcttg gccccgcaca aattgataat aggttcatag cccggataaa taggccctgg 1312621 cataatgact tcatcaccgg gagataaaat cgtccggaat gcagcatcaa tggcttggct 1312681 tgcgcctgtt gtgatgataa tttcagattc agcatcatag ttgaaatccg cttttttctt 1312741 catataaagc tgcacagctt gtctcagctc caggtagccg gcattcggag tatatgacgt 1312801 cacgttttca tcaatggctt tttttgcggc agctttcaca tgatgcggtg tgaaaaaatc 1312861 aggctggccg attgtaagtg aaatgacgtc ttcgtgttgg gctacaagat tcgagaattt 1312921 gcgtattcct gaaatttcga tctctcttgc tttcggattc agcaaatgtt ccataattca 1312981 tcaccttaac aaatataatg agtttatcct attttaccac tagctgatca tttgtcacct 1313041 ttttaactga tatatttcga ttgtatgcgc cttttttcta aacatacctt tcttttcaga 1313101 aaaaaagaag acaaccagcg atttgattgt ctttattgta tcatgttcta ttattgttta 1313161 tatgtgccaa tttcattaat agccataatc aaaatgaagg tcttcgtgcc aaatcagata 1313221 cggaggatgc tcttcttgaa ggtcagctga ttctttcttc atattcaggt aagtttcttc 1313281 actgatatcc tctaaaacag tcatttcgtt ttctttaaat attactaagg tacccattat 1313341 ttacaccctt ctttggaaaa atccttgact attttatcac tgttagttgg aaagtcaatg 1313401 gttattagga aaaaagtttc ttttttgagg aacgcggctt gttgccttcg gaattcgatt 1313461 ttgaagagct gccattcact ttttacaaat tacgccgata tatacagtac aatactgaat 1313521 gcgaatagcg agggattgaa ttgtcgttac aacaatacga aattttattg gattctggta 1313581 caaatgaatt agaaattgtg aagtttggcg tgggtgaaaa tgctttcgga attaacgtca 1313641 tgaaggtaag agaaattatt cagcctgtcg aggtgacatc agtgcctcac tcccatcagc 1313701 atgtagaagg aatgattaaa ctcagaggag aaatcctccc tgtgatcagt ctcttctcat 1313761 tttttggagt agagcctgaa ggatcaaaag atgagaaata tatcgtgact gaatttaata 1313821 aacggaaaat tgtttttcat gtcggctctg tttctcaaat tcacagagta tcctgggaag 1313881 cgattgaaaa gccgacatcg ttaaatcaag gaatggagcg gcaccttacc ggtattatta 1313941 agctcgaaga cctgatgatc tttttgcctg actatgaaaa aattatttat gacattgaat 1314001 cagattcagg tgttgacacg tataatatgc ataccgaggg cttcgatgaa agaagaactg 1314061 ataaaaagct tatcattgta gaggactcac cgcttttgat gcgcctcttg caggatgaat 1314121 taaaagaagc agggtacaac aatatcgctt cgtttgaaaa tggaaaagag gcatatgaat 1314181 acattatgaa ccttgctgaa aacgaaactg atttatcaaa acagattgat atgatcatca 1314241 ctgatattga aatgccaaaa atggacggac acaggctcac aaagctgctg aaggaaaatc 1314301 cgaaaagctc agatgtgccg gttatgattt tctcatcgtt aattacggat gatctgcgtc 1314361 accgcggcga agttgtaggc gcagatgagc aaatcagcaa gcctgagatc agtgatttga 1314421 ttaaaaaagt ggatacgtat gttattgaat aaataaaaac agccgttgcc agaaagaggc 1314481 acggctgttt ttattttaaa agtaactctc gccaagtttt ttaaagaccg gtttatggta 1314541 agctggctgc tggcgatttg gcactagcgg cttttctttc atgccgacat attcttgcaa 1314601 taggtgtttc gcttttgtta aagacatttg agctttagga tttcgatacg attgattaag 1314661 tgtacctaaa tgcggaagat gttcgaagtc ttctttagtt ggaggcatgt gaaaatagta 1314721 gtctccgatt gagataagca cgtccgattg ctgttggctg aaccttggat tttttgaaaa 1314781 atgaagccct attttctttc ctttaccttc tttgacaagc ttttgcaaag cccgtttttt 1314841 cagcagatat aggtatttag ggttgggggc ggtttttgca tggcggttca cagtgtaaac 1314901 tgcttttgaa agattttcta cggttggctg cagatctttc gtatatgcat ggtcgtccat 1314961 tatttctctc ctttgctctt atcaatttct atatgtttag attatacttt tttaaagttg 1315021 aaatgcaaat attgaatgta aaaatgcgct tttttctaag aaaaaaagcg catttttaac 1315081 ctgcattata cagatcttgc cttctttttc ggctgttctt gaaatgcttc ctgaacattc 1315141 acttccacag cctgagcact gtattttggc agtgcaataa aataaaaaat aaaaacgagc 1315201 aggataataa cacccatgcc gtaataaaga taatcaatgt ttgaaacaaa cttagggaat 1315261 aacagcgcga ctaagccgag tgtcaaagat tgtgcaaaca tcataaaagg gtcctgcatg 1315321 ccgcttacac gtcccatcag ttttggatga acaatttttg gcatccaccc tccgattgca 1315381 atgttgatcg gtccgataca cattcccagt gcaaaagctg ccgcgtaata cacccataaa 1315441 atattggtgt agccgaggac gaagatcagc aaacctgcaa tgaaaatcgg tatcgacatt 1315501 aaaaagtgcg gcttcacttt tttagagatg agcgtgccga ttacgcttcc tgccagaagc 1315561 ccaaacccga gtgcgatcgt aaatacagac gtatgccact cataacggtc aggcgccaat 1315621 ccatatttca ttgtaaacat cggcaatacg gcgaatcctc cattgacaaa tccaaaaatg 1315681 aagaagccaa aaataagaga tgccagcaat ttgtttttta aaatatagag gatgccttct 1315741 ctaaagtcat ttattgaatc cttaacagaa gtctttctcc agctgaatgc accgtttggc 1315801 tgtcgggctt cttttggaat ccggcagctg cggatcagca gcccggaaat gataaagctg 1315861 acaaaatcaa gaataatggc gccttcaata ccgattgtgt tgtacataaa cgcgcctatg 1315921 ccgactccaa acaccataaa aatgctaaaa agcatctgat taagccctgc cgctttcgca 1315981 taatgctcct tcggcagaat ggcttgtacc aaactgtttt ctgccggaaa gaaaaacttt 1316041 gttacagcgc ttctgataaa taagatacaa aaaacaagag gaatattgcc ggtaaataaa 1316101 gtgaaaaaaa gcacgacagt caggcctgct ctgatccaat cacaattttc tgccaccttt 1316161 tttctatcaa accggtccgc gacgactccc acgatcagaa atacaaatat ggtcggaaga 1316221 gaatacatca gctccgccaa ggtcgtatat gaaggctggc tgctgaatcg gtccagcaaa 1316281 aaaaaagcaa aggccatgtt gcctactgtc gtgcccattt gagaagcgag tgctgcgaaa 1316341 aatagacgaa caaaattacg atttttaaat atatccataa aaacgctcct taccctaaag 1316401 gtcccacttt atcatattat aaaccgcctg tttttgaaac aaataagaaa acattaccgg 1316461 ttaatcgtga ctctcgttcc gtttggcaca attgaagcaa gttcgatcac gtctttgtta 1316521 tgcatgcgaa tgcagccttt agaaacagcc ttaccaatcg aagcgggatt attcgtccca 1316581 tgtattccgt agtgctgctt tgaaaggctc agccaataag cgccaaatgg gccgccggga 1316641 ttgcgctggc ggttaataat gtaaaactcg ccagtaggcg tttgcgttag tattttacca 1316701 acggcgatgg gataggtttt cattacccga ttatttaggg acagcgtaag ggtcttcgct 1316761 ccgattgaga ctgcgatatg atacggaatt gtataagggt ccggcagtcc ggggatgact 1316821 atggactgtc ccgcggtgag ccctgcctgc agtgacggat tagcctggag taatgcagcc 1316881 gtgctgattc tgaaatcagc cgcgatgctg ttcagtgtat caccttgctt cacctggtac 1316941 gtaagcagtt tcctcatcct ccttttttac ttataagtat tgatgaggag cccatcctgc 1317001 tacattaatt tgtgcttttt aaggtgaaga cagtgatttc aggcttggca agaaaccgca 1317061 aaggcagcct ggtcatcccg aggcctcggt ttacgtaaat atgagtgctg cccgtttgat 1317121 acattccctc tgtgtagact tttccatatg gaggcgtaat aatcggtccg taaaaaggca 1317181 gctgaatctg gccgccgtgt gtatggccgg aaagctgaag gttcacggga taatctgttg 1317241 ttttcaaggc tgcatcaggt tcatggacga gaagaatgga aaaaagtctg tcgctcagcc 1317301 ttgaaagggt gccttcataa tctgggtttc ccagcattaa gtcatcaagc gaagcaatct 1317361 cgattttgct gccatctgcg agtgacaatg tttgatagcc attgcgatat accgtgaaac 1317421 ctccggccgt catcaggctt ttgtaaacgg cagttccata gcctccgtga tcatgattgc 1317481 cgtaaataca aagcttgccg aagggagcat taagctttct caataatgga atgactgcct 1317541 ggtggtgctg gtacgtatca ggattatcaa taatatcacc tgtaaaaaca atgagatcag 1317601 gtttagattc attaattgta agaatgacag tttttaaatc ttcgagagta aagtaatcac 1317661 tcaagtgtgc atcgctgaac tgcacgattt taaaaccgtc aaatccgtgc gggatgagag 1317721 agctttttat tgtgtgttcg gttgtctcga tcatatgcgg ctcgagatac ctggcatagc 1317781 catatccccc gccggccgtt aaagccccgg cagcaagagc gccgaacatt ccttttagaa 1317841 attgtcttct ggacatcttt ttcatttcaa accaaccttt aatagagttt ttctattata 1317901 tcatctgtat ctgataaaaa tctcatatga gcatgtgctg acagaggcag ggatataatg 1317961 atagaatatt attgaatgaa taatcattca caattggagg gataaacatg gaaaaaaagg 1318021 cggtaattat taccggcggg tcaagcggca tgggaaaagc gatggcaaaa aaacaggctg 1318081 aattagggtg gcacgttatg gtgacaggga ggaaccatga ggcacttgag gaaacaaaaa 1318141 aagaaattca gacctttgag ggacaggtcg cttgttttca aatggatgtc cgttccgatt 1318201 ccgccgcttc agacatgatt aaagaagcgg taaaagcctt tggccggctt gacgcgctga 1318261 ttaacaacgc ggccggaaac tttatttgtc cggcagaaaa gctgacgccc aatggatgga 1318321 aagccgttat tgagattgtt ttaaacggca catttttttg cagccaagca gcggcaaggc 1318381 attggattga ccagaagcag cagggtgtca ttttaaatat ggcagccacg tacgcttggg 1318441 gagcgggagc gggggtcgtt cattccgctg cagccaaagc gggggtattg tcattgacaa 1318501 gaacgctggc cgttgaatgg gggagcaaat acggcattcg tacaaacgcg atagcccccg 1318561 gaccgattga acgaacaggc ggtgcggaga agctatttga atcggaaaaa gcgatggccc 1318621 gcacgatgaa cagtgtgccg ctcggccgat tgggcacacc ggaggaaatc gccgctttgg 1318681 cagcgttttt gctttctgat gaagcatcct atataaacgg ggattgtatc acaatggacg 1318741 gggggcaatg gctgaatcct tatccgtttt aatctgaata tttataagtg aatatttaag 1318801 ttattaagaa cttttatgtt cgaatgtaat acctccacaa ttaaccttct tcctatccaa 1318861 tttgataaca catagagctt tatttgttta tgaggtgttg tgtcatacgt aagccaccta 1318921 atatatgaaa ggtatatttt aaaaggggag acgaaatatg aagaacttag atttcaaata 1318981 aaacattcat ataattactt cgttaactaa aaagagaaat tataagaatg aaaggtttca 1319041 aggttacatc agattgggag gaaggtaata taatggacga gatggtatta ttaactcagg 1319101 aatggctcaa tgaaacgtac aaaggaaaaa gtggctacaa ttccattgag gaaaatggga 1319161 aaactggctg gaaaacaatg tatgcattaa ctagagcatt acaactagaa ttgggaatta 1319221 cacagacttc cgacagtttt ggtcctacaa ctttaagaaa gcttaaagaa ttaggcccga 1319281 tttctacgtc aactaattca aaaaaaaata ttgtgaaaat tattcaaggt gctctttatt 1319341 gtaaaggtta tggtccaggt ggattaacgg gtacatttgg tcagggaacg aaagaggcga 1319401 tagcagaaat gcaattgcat atggggcttt ctaaaacaga cggtgtagta acgcctaagg 1319461 tgtttaaagc tttattaaac atggactctt atatcctttt aaatggggcg tcagagaaag 1319521 ttcgttcaat acagcaatgg ctaaataata aatattacaa tagagagaat ttctacttta 1319581 tgccctgtga tggcctgtat tcaagggata ctcaaaagtc tcttgtttat gcaatacagt 1319641 acgaggaagg gttaagtgat agtatagcta atgggaattt tggaccaact actcaaagat 1319701 tgattcctgt attaagaatt ggagaaacag atgaaaaaaa cagttttatt catttatttc 1319761 aagctgctct aatctttaat ggctacaatg ttccttttga tggagtatac tctgaatctg 1319821 taagatcaaa agtaaaggct tttcagtctt ttgcaaaatt acaacagagt ggtactgccg 1319881 actttcaaac atgggcttca cttctagtaa gtactggaga ccccaatcga aaaggagttg 1319941 cttgtgactc aattactcaa attacatcgg acagggcgga gtcccttaag agggcaggtt 1320001 ataagattgt agggcggtat ctaacaaatg cgccggggag tacactaaat aaaaaaatac 1320061 aaccaggtga attagaaact atcttaaaat caggtttaaa tgtttttccg atttatcaaa 1320121 cctatggggg agcaacaaat tattttaata aagaacaagg aaagaaagat gcgtttgctg 1320181 cttataaagc agcaaaagaa tacgggttta aaaataacac tgtaatatac tttgcagtag 1320241 attatgatgc atatggtaac gatttaaaca acaatattat tccacacttc gaaggtataa 1320301 atgaaataat gaacggtttt ttaggttcaa cttacaaaat tggtatttat gcccctagga 1320361 atgtatgtac tatagtttct aaaaaaggtt tagcatttgc aagttttgta agtggtatgt 1320421 ctactggctt tagcggaaac ttaggatatc ctttgcctta caattgggcg tttgaccaaa 1320481 tttcaacaat tactgttgga aatggttctg gaatgattga aattgataat gatatttgtt 1320541 caggtttgga taatggagtt aataccataa atatagtgcc ttcagagaat aagaagtttt 1320601 ttgatcaaat tgatgtttta tatgaaactg ctgaaaaata tgctcaaatg caaagcgact 1320661 taaataatgg ggtaaaaaaa acacaattag ctaatgagtt ggttgcccag tatttaagaa 1320721 aggatgacta caaagggtgg aagtgggtcc ctaccgcagg ccagattgat cctatttatc 1320781 gtgaatgggc agtaaagcgc taggggaaga cctagtaaat ggaattgttg atcctatatc 1320841 aaaaactgtc ataggaacgc agcatcttat ggcaacttat aatgccatta tttatagtgg 1320901 tggttactct caaacactac gagattttgc tggttggact ggagatctat taacaacaat 1320961 acaggacatg aaattacacg ctcaagaatt taattcgcct tatgatgcgg ctatgaaaat 1321021 aataggtaat atgtatcaat ttagcctaga tgatttattt agtgatgtag atgcaattaa 1321081 tctagcgaat aaaacatcag ttggtgctaa tgcacaacct ctaaatatcg caattagaga 1321141 ttattatagt aataatgact gtatgaatag gttcactcaa tttgtaaata atagatttga 1321201 tggttcgtta gacaaaattt tctctgaagc agagtattat ttaaatacaa accttgaccc 1321261 agttgttgtt ccaattaggt tagcctttaa acgtgctttt gatgttgagg attatagtga 1321321 agagattgga aaaataacag cacaagcatt tagagatgtt atcgagaaaa aaatgatatc 1321381 tgaataaact gcaaaacaag cgaacgttaa aactggtcgt tcgcttgttt tattttctat 1321441 ttaaatttat gatataattt ttaaagatta aggagtgatt cattgaagaa attgttaaaa 1321501 aagttagttg tattattttt aagcagttta gttatcatct ttaatgtttg gtactttatt 1321561 atttgtgctt tttccccaga gtattatcaa aatacaaatc ttacttctaa tgaaataata 1321621 agatttgaaa aactatacca catagatttt cctgatgaaa caaaatttat taaagctaga 1321681 gagtatttgg ctgggcccgg aggagatacg tcagctgtat tatatgtgtc tctgccaacc 1321741 aagcgggtag aaaaagtttt atctgattac acgtatatga aaataaacta tactgacaat 1321801 gtcggttcaa tgtatggagt tgacgtttca aagagtgtcg ccggtttaac aactcttaca 1321861 tttggcactt acgataaaaa aggaactttc tataatatga aacatgatga tgattggatg 1321921 tataaaggca ctgactggaa tctttacttt tggacagctg ctagttataa tgctgttatt 1321981 tttgtatttg ttttggttat tgtgaaacaa atgaataaaa ttcttaatta accagtatgt 1322041 agattgataa tctcaaaaaa attttcctct tcttttaaca tactccatac gacctacttt 1322101 tccatactat gatttttttg aaatttgtgg tgtagttata attgtgcgta taatcagaca 1322161 aagatagaga agcaggtgat aacatgttgg atccacttga tattttaacg aacattgatg 1322221 atgtccttcc atattaccag gcgattttta gtgccgagga gcagaaggtt gtcggatatg 1322281 aggtgcttgg acgaattttg gcagattcag aaatccaaag tctcgggccc ttctttttag 1322341 atgcggggat acccgaagaa tataaattag aggttgataa cagaattatc cgccaggctc 1322401 ttgaccgctt tttagaggcg gattctgatc tgctgatttt tatgaatcag gatgccaatc 1322461 tgctgatgct ggatcatggt gaaagctttc tggagcttct gaaagaatat gaagcgaagg 1322521 gaatcgaact ccaccgtttt gtgcttgaaa ttacagagca caattttgaa ggggatattg 1322581 agcagctcta ccatatgctt gcatactatc gtacatacgg aattaaaatc gcagttgaca 1322641 acatcggaaa agaaagcagc aacttggaca gaatcgcgct gctctcacca gatctgttaa 1322701 aaatcgattt gcaggcgctg aaagtgtcac agccgtcacc gtcatatgag catgtgctgt 1322761 acagcatatc tttattagca agaaaaatcg gtgcggcgct gctgtatgaa gacattgagg 1322821 cgaacttcca gcttcagtac gcctggagaa acggaggccg ctattttcag ggctattact 1322881 tagtgtctcc atctgaaacg tttctagaga gagatgtatt gaaacaaaga cttaaaactg 1322941 aatttcacca atttatcaca catgagaaaa agaaactgga gaccgtctat gagcactctg 1323001 aacagtttta caaacgagtg catcaggctg tgacctcttt gagaaaaaac aatctgtctt 1323061 ctgatgatga ctttattaaa aagctggcgg aagagctgac agattgcagc ttcaggattt 1323121 acatgtgtga tgaagaaggc gatcagctga cgggaaatgt gtttaagcaa gatggagaat 1323181 ggatttatca gccggaatat gcggaaaaga actggagctg gcgcccttat tttctggaga 1323241 acattatgag aatgagaaat ctcagaaaag gttttttcag tgatctgtac agtgatttgg 1323301 aaacaggtga aatgatcaga acgttttcat atccgatgga tgatcagatg tatttattta 1323361 tagacttgcc ttattcttat ttatatgagc aggacggact gatttaacgg ctgaaaggcc 1323421 gtttttttta tgaaatgaaa aaaatatcaa aaaacgattg acattgatac tgagaatcat 1323481 tatcatttaa ttatagagag aagctactct ctgttcccca acccctctat cagatcaaga 1323541 tccgaaaaaa cttggcgcta cccccgccaa gttttttatt tgtcaaagca taggacaatc 1323601 caatgaaaca ataaacctaa ctagtggtaa acgtttaaca cggggagaaa cattgagtgc 1323661 cgaacacccc tgacactgct gcacgggtga ggaggaaaat tcgttctgaa atgattattt 1323721 cagttccgtt gtttacctct atccagcatg actcccattg attatggcca cgcgggactt 1323781 caccataaaa ttcaaaagaa ggttttgaca aagttgcaaa aaggcattct taatgctgcc 1323841 aaagattcga aaaaaattat aattatgtgc atgacattca aaaaaagcct caaactaaag 1323901 aaaaatagtt tttttcactt tttttctttg cttaaattca gcagtgaaaa tgccatcctg 1323961 tccgacttta tggtatgatg ctcaatagaa cttgtattat aataaatact tgttgatttg 1324021 aagttgcttt ttgaaaggag tcttttttta gaatgtcaca attaatgggt atcatcacac 1324081 ggctgcaaag tctgcaagaa acagcggaag cggctaacga gccaatgcag cgttatttcg 1324141 aagtgaatgg tgagaaaata tgcagtgtta aatatttcga aaaaaatcaa acgtttgaac 1324201 tgacggtttt ccaaaagggt gaaaaaccta acacatatcc gtttgataat atcgacatgg 1324261 tttccatcga aatctttgaa cttcttcagt aagattcctg aaataggggg aacaagcttc 1324321 cgcctttgca aaagtaatcg aaataaacgg taaggaacat acttgtttca tggttgtaaa 1324381 tccttgaaaa ggagtgtcgt gatggctgat tcttttctgt tttataatct ttcagaagca 1324441 cagatgacct ttcaagatgt gatggaacgg cttaaagcct ttgttcaaaa ggacccccgt 1324501 tcttcttatg tgttatcgat cggaaccgat tcacaggttt accgcgatta cacaaagttt 1324561 attaccgcat tgcatttgca tcgtacaggc aagggagctt ggggctgctt gaaaaatcat 1324621 acagtcgaca gacccataca tagccttcgg gagaagattt cgttagaaac ggcgtacagc 1324681 caagaaacgg ccgctcatat tcttgatgga cacttaatgg atattaccga tctgctcctg 1324741 ccctttaccg gtgagggggc ggatcttacc tttgaagttc acttggatat tgggaaaaaa 1324801 gggcttacaa aagatctgat ccaagaaatg actggacgta ttacctccat ggggattgag 1324861 gccaaaataa agccggattc atacactgcc ttcagctatg caaatcgttt cacaaaataa 1324921 tttggctgaa aaagccaagg taaatgtcga attatgcggt tgacgtttgt tatctgatta 1324981 cttattctag cggtagagct gaaagtaagt tgtcttgctt tcagaggtat tcagtataaa 1325041 acagggggcc tgattgcgaa tgagtcttat cggtgaacga tttacagaag aagaacaaaa 1325101 acttctgctg aatatcctga tcaaccatga gtatgccatc gagctattaa gcagtgagat 1325161 caacgatata gagacaggga ccaaaaacgt tgacggaacc acctacaaaa aacttgtaac 1325221 gctatacgac cgatttcgat ttgaaaatta atgggacacc ctataattga tactccacaa 1325281 agagtatctt ttttattgaa aggaaacttt tcgacaaata ctgataaagt ttatattatt 1325341 gcaatatagg gaatgtattg atgatgaaaa tgaaaagggg tcgaaaacat gataagctta 1325401 caatcagatc aacttcttga ggcaacagtc ggacaattta tgattgaggc ggacaaagta 1325461 gcgcacgtgc aagtcggaaa taaccttgag catgcattat tagtattgac aaaaaccgga 1325521 tacacagcca tcccggttct ggatccttcc taccgtttac atggcttaat cgggacaaat 1325581 atgatcatga acagtatttt tggacttgag cgaattgagt ttgaaaagct tgaccaaatc 1325641 actgttgagg aagtcatgct gaccgacatt ccgcgccttc atatcaatga tccgattatg 1325701 aagggattcg gcatggtcat taataacgga tttgtctgtg ttgaaaatga cgagcaggta 1325761 tttgaaggga tttttacgag aagagtcgtt ttaaaggaat tgaataagca tatacgctca 1325821 ttgaataagt aggctgtacg gtcctatttt tattatatag gcagagtgaa aaaagaaagc 1325881 gcatacataa tttaaacgag aatagggctt gaataagaaa ctaagatttt attagaatgg 1325941 gagataagaa aaacttattg ataacaaaaa ggaggacgac atgcagcttc aagagcttca 1326001 tatgctcgta gttttagctg aggaattaaa tatgagaaag gcggcagaac ggctttttgt 1326061 atctcagccg gctttatctc agcgcttaca aaccattgaa aaggcgtggg gaacaaaaat 1326121 ctttttaaga tctcaaaaag gattaacggt aacgcccgcc ggtgagaaaa tcattcagtt 1326181 tgcgaatgat gtgacattag agcaggaaag aataagagaa aatattgacg agcttgaagg 1326241 tgaaattcac ggcacattga agcttgccgt cgcctccata atcggtcagc attggctccc 1326301 taaagtcctg aagacgtatg tggaaaagta tccgaatgca aagatctcgc tcataaccgg 1326361 gtggagcagc gaaatgctga aaagcttgta tgaggatcag gttcatatcg gcattataag 1326421 aggcaaccct gagtggaagg ggcgcaaaga ttacttaatg acagatcatc tgtatttagt 1326481 ggatactgaa atttcctgca tcgaagatat tgcccataca gaacgtccgt ttatccagtt 1326541 taaaagtgac agcacttatt ttcaggaaat tcagcactgg tggcatcaaa aatttaaaac 1326601 gtcgccgaaa cagacgatat tggttgatca gattgaaacg tgcaaacaga tggcgctgca 1326661 cggaatcggt tatgccattt tgccgtctgt tacccttcaa aatgaagata aagtgaataa 1326721 aatgcctctt ttagacatga aagggcatcc gatcggtcgg gatacatggt tattaggtta 1326781 tgagcctgcc tttgaactga aacaagttca agcttttgta caagtgataa aggatatgct 1326841 ggatcaggaa aatccatttt aaagacagcg aggtgctgtc ttttttttat ttatctgttg 1326901 acaatgaaaa tcattatcat ttaaagtgat acatatgata ttgaaaatca ttatcaacta 1326961 atggggtgat aacatggcta aagccttgat tacatatgcc agcatgtcag gaaatacaga 1327021 agacattgcc ttcataataa aagatacgct tcaggaatat gagttggata tcgattgtgt 1327081 cgagataaat gatatggatg cgtcttgttt aacctcctat gattatgtac tgattggcac 1327141 ctatacatgg ggggacggcg atttgcccta cgaagcggag gattttttcg aagaggtcaa 1327201 acagattcag cttaatggtt taaaaacagc ctgcttcggg tctggcgatt attcttatcc 1327261 aaagttttgc gaagcggtga atttgttcaa tgtcatgctg caagaggcgg gagctgctgt 1327321 ttaccaggaa acactaaaaa ttgaattagc gcctgaaaca gatgaagatg tggaaagctg 1327381 ccgagcgttt gcgagaggtt ttcttgcatg ggcagattat atgaacaagg aaaaaatcca 1327441 tgtttcataa aggggcaacc gctgttacgg catcggcgtt ttctggatat tttgtggcgg 1327501 tacaaagaga aggcattttt cattactctt tggagcaggg ctggagaaag ctttttcgtt 1327561 tgaaaagtaa gatacactgt atcagctaca tagggcctta cttatttggc gttggtgaaa 1327621 agggaacagt cattcgttcg gctgatgaag ggaaaacctg gacgatgtcg agctttccga 1327681 caaatgcaac agtgtgggcg attaccggca gaaacaacgg gtttgtctgc gcccacggta 1327741 agcattgtat ttatgtatcg gatgattttg gtgtctcatg gcgcgtagcc aaaccttttg 1327801 ccgaatttca taatccccct gttatccggt cgttatgcct tcacgggggc aatctcttta 1327861 tcggcacgca aatacacgaa tattttggcg gcatttgggc ttacgacatt aagcgtgaca 1327921 ctgtccaagt tgtcaaaaaa gaaaaaaacc ggatgacggc atccatgctc gtgttcaatg 1327981 aaaattggct ggtggcggcg atgggttctg tgaaaggaaa gcacggtgct gtcactgtaa 1328041 ggaatctttt gaatggtgaa gaattcacca tacaatccag tatgatcaga aatgaagaat 1328101 catttcttga tctttcagag gatgatggca ttatatatgt cactacaaca caagatgaaa 1328161 atggtttttc gagaatttac caggttgatc tcgaagcccg gtcgttaaaa tggttcgata 1328221 ccattaaggg acatggatgg agagtggcca atcagaaaga gaatttcttt tgcgcaggct 1328281 tgtatgaatg taaatttgtc cagccgtacg aagtttcagc aatgattcat tagaggagga 1328341 acaaggaatt ggcgaagatt ttgctcgttt atgcaacaat gtcaggcaac actgaagcta 1328401 tggcagattt gattgaaaag gggcttcagg aggcgttagc agaagtagac cgtttcgaag 1328461 caatggatat tgatgatgcc cagctgttta ccgattatga ccatgtcata atgggaacct 1328521 acacgtgggg agacggagat ctgcctgatg aatttttaga tcttgttgaa gacatggagg 1328581 agattgattt ttccggcaaa acatgcgctg tattcggttc cggtgataca gcatatgaat 1328641 ttttctgcgg agcggttgat acgctagagg caaaaataaa agaacgcggt ggagacattg 1328701 tgctgccttc ggtaaaaatc gaaaataatc cagaaggtga agaagaggaa gaattaataa 1328761 acttcgggag acaattcgca aagaaaagcg ggtgcgctgt ctgatcactc actgggaact 1328821 gctaaaacgg ctgttccttt ttttcttgtc tttgtatctt tcctttgata cagtaatgag 1328881 gtagaaaatc aggaggagga ctatacatat gaaaatgatg gacgcaaatg aaattatttc 1328941 atttattcaa aatagtacaa aatctacacc tgtaaaggtt tacgtgaaag gtgagctgga 1329001 aggaatcaat ttcggtgaat ctgcgaaagc ttttatcaat ggaaacactg gtgtcgtttt 1329061 cggtgaatgg agcgaaatcc aaacagcaat cgaagaaaac caaagcaaaa tcgaagacta 1329121 tgtggttgaa aatgaccgcc gcaattctgc gatcccaatg cttgatctta aaaacatcaa 1329181 agcgcgtatc gagccgggtg cgatcatccg cgaccaagtt gaaatcggtg ataacgcagt 1329241 catcatgatg ggtgcttcta ttaatatcgg ttcagtcatc ggcgaaggca caatgattga 1329301 tatgaacgtt gtgcttggcg gacgagctac tgttggaaaa aactgccata tcggcgcggg 1329361 ttctgtactt gcgggcgtta ttgagccgcc atccgctaaa ccggttgtga ttgaagacga 1329421 cgtcgtaatc ggcgcaaatg ctgttgtgct tgaaggtgta acagtaggta aaggagctgt 1329481 tgttgctgcg ggagcgatcg tggtaaacga cgttgagcca tacactgtcg ttgcaggcac 1329541 accagctaaa aaaatcaaag acattgatga aaaaacaaaa ggcaaaactg aaatcaagca 1329601 ggaattacgc cagctgtaag gaaaagtttg ataaaaaagg cgtggataat atatccacgc 1329661 cttattcgta taggcaggag gaatagaaat gaagatagag gagctcatcg caattcgcag 1329721 agatctgcat cgtataccgg agcttggatt tcaggagttc aaaacccagc agtatttatt 1329781 aaatgtcttg gaacaatatc cgcaagacag aattgaaatt gagaaatggc gaacagggct 1329841 ttttgtaaaa gtgaacggga cggcgccgga aaaaatgctg gcatacagag cggatatcga 1329901 tgcgctttct atagaagagc aaactggtct tccattcgca tcagagcatc acggcaacat 1329961 gcacgcctgc ggtcacgatt tgcatatgac aattgcactc ggcattattg atcattttgt 1330021 tcaccaccca gtcaaacatg atttgctttt tctgtttcag ccggcagagg aagggcctgg 1330081 cggtgcggaa ccaatgcttg agagcgatgt attaaaaaaa tggcagcctg atttcatcac 1330141 tgcccttcat attgctccag agcttccggt aggcaccatt gcgacaaaaa gcggccttct 1330201 atttgcgaat acatcagagc tagtcatcga tctggaaggc aaagggggac atgcggcata 1330261 tccgcatttg gctgaggata tggttgtagc agcaagtaca cttgtcaccc agctgcaaac 1330321 gattatctct agaaacacag atccgctaga cagtgctgtt attacagttg gtaccattac 1330381 cggaggctcg gcacaaaata tcattgcaga aacggcccac ctggaaggca cgatccgcac 1330441 gctttctgaa gaatcgatga aacaagtaaa ggaacggatt gaagatgtag tgaaaggaat 1330501 cgaaatcgga ttccgctgca aaggaaaagt gacatatccg tctgtatatc accaagttta 1330561 caatacgagc ggattaacag aagaatttat gtcttttgtt gctgaacatc aactggcgac 1330621 agtaattgaa gcaaaagaag caatgactgg agaggatttt ggctatatgc tgaaaaaata 1330681 tcccggattc atgttctggc tcggcgctga ttctgaacat gggcttcatc atgctaagct 1330741 gaatcccgat gaaaatgcga tagaaacagc ggttcatgtc atgacaggtt atttttctgt 1330801 ttatgccaat taagtacaaa tgaaagaata aaattccata aaatgagcac tctagtaaac 1330861 ggaggtgttc aaaaatggct aaaaaaattg gaattgaaca atcgttatca gatgtagaag 1330921 ctgctttaaa agaaaaagga tatgacgttg taatgatgaa aagccctgct gatgctcaag 1330981 gctgtgactg ctgtgtcgta acaggtcttg ataataatgt gcaagggata gccgatacgg 1331041 taacacaagc acctgtcatt acagcttccg ggatgacggc tgaagaaatt tgtagcgaag 1331101 ttgagagcag aattcagtaa taaaaaaacc gaagcaaaaa gcttcggttc ttttatttat 1331161 tctgtttctt tagggaaagc gcggtcgaac gcgttcttta tttcttttct caacactcgt 1331221 tcgactcgcc actgttccat attttctgtt ttggcaatga ccctgattac aatttcagaa 1331281 gtccccagtt cttgaatccc gatgacattt gggccttctt ttatttgtgg aagagccgct 1331341 gccgtttcat cacaaacctg ctgtaaaata tgaatcattt catcaatatt tctttcagcc 1331401 ggcactttaa tgtcaacaag agcctgcatg gtaccacgag aatgattgct cacgtttgtg 1331461 atgtttctgt tggggatgta atgcagtgtt ccgtcaaagc tgcggatttg agttgtcctt 1331521 aagccaacct gctcgacaat tccgtcaaag gtggaaacgg taatataatc tccgacatcc 1331581 aattgtttct caagcaaaat aaaaaaacct gtcacgatat cactgacaag cccttgggcg 1331641 ccaaatccga cagccaggcc gacgattcct gcccccgcta aaagagcgct tggatcataa 1331701 tgaaacaaat ctagaaccat gacgaaaaat atgaaaatca atgtataagc aaatatgtta 1331761 agagtcaggc ttcggagcgt atgtgcacgt ccgatagaca agctattctg ctcctcgaat 1331821 tttgcaaaca gatgtttaat gattttcatg cctaatgatc gaacgataaa atagagcaat 1331881 atcataatgg cgagtttaat gagcagaaca ccggcatttg taatcagtcc cgcccaatca 1331941 tattgtttaa taaagtccat gttgagctcc ttttctaatt gattgctgca cattgagact 1332001 agttaccctg tacatgacca tgttaaacgt tttattcaaa aatgtcgaag ccaaagacat 1332061 acatgatttg ttaaaaattg actcaggaaa tctgctttta tataatggca ttgcaatata 1332121 actaaaaatg gttaatcacc ctttattttc atgcgatttt gacctttaag ccaaacaata 1332181 aattggaggg atacatatgg cagaacgtat ggtaggtaaa caagctcctc gttttgaaat 1332241 ggaagcagtc cttgcaagca aagaattcgg caaagtaagt cttgaggaaa acatgaaaaa 1332301 cgacaaatgg acagtgctgt tcttctatcc aatggacttc acttttgttt gtccgacaga 1332361 aattacagca atgtctgacc gctatgacga gttcgaagat cttgatgcag aagtcatcgg 1332421 ggtttcaact gataccatcc atactcattt agcttggatc aatacagacc gcaaagaaaa 1332481 cggtcttggc cagctgaaat acccgcttgc tgctgataca aaccatgagg tatcccggga 1332541 atatggcgtt ttaatcgaag aagaaggtgt ggctttgcgc ggattgttta ttattaatcc 1332601 tgaaggggag cttcaatatc aaactgtttt ccataacaac attgggcgtg atgttgatga 1332661 aacgcttcgt gttctccagg cgctgcaaac tggcggactc tgtccggcta actggaaacc 1332721 aggccaaaaa acactttaat tctttccaag aacgaaaagc ggtctagcat attcgttagg 1332781 cctctctttt aaaataggag ggaaaaagca atgaaattac gtcagcccat gccggaattg 1332841 acgggagaaa aagcttggtt aaatggtgaa gtgacgagag agcaattgat tggggaaaag 1332901 ccgacgctta ttcatttctg gtccatcagc tgccacttgt gcaaagaagc gatgccgcaa 1332961 gtgaatgaat ttcgtgataa atatcaagat cagctgaatg ttgtagctgt acacatgccc 1333021 cgttccgaag atgatcttga ccctggtaaa attaaagaaa cagctgctga acacgatatc 1333081 actcagccga tttttgttga cagtgaccat gctttaaccg atgcatttga aaatgaatat 1333141 gtacctgcat attatgtgtt tgataaaaca ggacagctcc gtcacttcca agccggcggg 1333201 agcggtatga aaatgcttga aaaacgtgtg aaccgcgttc tggctgaaac ggaataggta 1333261 tctgactaaa tagtatttcc taaaaacctg acctcatcag gttttttatt tgtgcaaaaa 1333321 gcaatggaag aagagtaaga agcttatttt tccaaatttg ggtataggaa ttgatgattt 1333381 gtttgattga tacgctaaaa aacacagcta atttttgatg tttttcctca attttagata 1333441 aatctcatat ctcataactc gaaaattgta gatattacac taaatttctt taaagaagta 1333501 agtaaaatat atattttcaa cattatacca aataaactag aaagcccctt aatcccttga 1333561 gaataaagga ctcttttgaa aaataaaaca ttttcagaaa ataaggaatt tttcatagag 1333621 taaatataat agtaaaatgc taaaataata gttgataaaa ttacttttgt aatctaatat 1333681 cttaattaaa gatgttaatt ttgatagggg gtacattgag gaatgtttaa tgaaagagaa 1333741 gctttgcgct tgcggttaga acaattaaat gaagctgaag tgaaagtcat tcgtgaatat 1333801 caaattgaac gtgataaaat atacgcaaaa ttaagagagc tggacagaaa tggaagccct 1333861 tccgaaatca aaaaggattt ccgttctgaa aaaaaacctg actctctgcc ggttctcgct 1333921 gagcttgcgg ctcaggaaat cagaagctat cagccgcaat cacagcagca gtctgttcag 1333981 cctcagcttc aatctatttc ctctcttcct gccggtatac cagacggaac aacacgaaga 1334041 agaagaggaa cggcaagacc gggatcaaaa gcagctaagc tgcgtgaagc tgctattaaa 1334101 acattaaaac gccacaacgc ggcgattaag agctcggagc ttcaaaaaga gattgaaaaa 1334161 gaaagcggtc ttgaaatccc taatatgaca acgtttatgc aaagcttaat taaaatgtac 1334221 ccggaagtga aaaagccata tcgcgggcag tacattttag agggtgaaat cgaatctgca 1334281 gaatcagcaa acgaataaat ataaagaaaa actgcttggc atcgctcaag cagttttttt 1334341 attgaggttt tttctgtgaa ggtttgtttt ctttttcaag attaagctta tacacccact 1334401 tttgataagg cttttcttca gcggctctgt ttttcagctc ttcgattgta tggctcttgg 1334461 cctggtctga tgattgggcg tgggcaagct gtttttgaag cacatgtatc tgtttggtga 1334521 catcttcaag gatagtctct acatgatttg gctgcgcgta ggccgctgga gcttcttctt 1334581 ccgttttttc tttttgtttc gtgccgccat caatatcggc aaaatgagaa gcaatccagg 1334641 catcgctttc atcaagttgc cgtttatacg atataatagt ttcgtgaaat aatttttctt 1334701 tcgttttttc tatgtctagc agtctttctt tcgtttctat gattcgatct ttcatatgat 1334761 caacttctat tttaatatgt tttagctgat attctttttc taccatttgc tcttttagac 1334821 gcccgttttc ggcttttatc aattcggctt gctgttttgc ctgaagcagt gcattttgtt 1334881 cctgctcaat tgaggcttga agttcgctga tccgtttatg aagattttta ttttcttctt 1334941 cgattttgac tttcgcaata tgaagtttat gtttttcttc gatttcggct ctgcgtttat 1335001 aggtttcagc agatagaagc tcctgcaaaa caacgatttt atcaagcagt tcagctctta 1335061 tttggtgcag ggtttggctg gtgtgggagg catgtttttc ttttgttgac atatgtgtta 1335121 attcggcaga cagctgctgg agtttttctt tcatatcggt attttctttg agcagtttgt 1335181 tatttttctg atgaaagtag cttgcttcaa gttcagaaat cagcttatgg caccttgaaa 1335241 gctcggattt taaataaagg ttctcctgag acacgtcgtg gaaaaaagga cctgatcttt 1335301 tcattcgaac catctccctc atgatgttaa cactacaata tgcaaatact gaacagctat 1335361 tcctctttaa taaacagaca agcagtagcg ttgagccttt gcttttgcta tgcttttaac 1335421 gaaactagag gtgagatgat atgaagcatg taaacgtact gctggcaggg ggagcctcac 1335481 gtcgctttgg agaaccgaag gcgtttgtca aatggaaggg caggatgctt tacgaatgcg 1335541 ctaaagaggc acttggagaa caaacggtta tcatcagccg tcccgaattt attgatagat 1335601 ttcaagaaaa cggtgaaaat gaagtgtatc aagatgctga gccatttcaa ggcatggggc 1335661 cattggctgg tatatatacc gcttttaaaa agacagacgg tgatctttat actgttcttt 1335721 cctgtgacac accgctgata caaagaagga cgatgctgga gctcaaacgt ctgatgattg 1335781 ccggtgcgga cgcggtagtc ccaatttcag acggacaagt gcagccattg attgcgattt 1335841 accacaaacg tatcatgcca gttctatacg atcagctttc tgagaagagg ttgagaatat 1335901 cagatttatt aggcagaatt tcggtttgtt acgtacaggc tgaaaatatc ggagcaaacc 1335961 cggcagagtt tatcaacatt aatacacgtg atgattttag ctgtttggaa gaaaaatcga 1336021 actccctcaa gcgggactga cggggcaata acatgataag atgacataaa agataaggag 1336081 aacaggtttg atggaggaac gttattcacg gcaaatcaga tttaagcaaa ttggggaaga 1336141 gggccagaaa agactggcag acagccatgt gctgattgtc ggagcgggag cgctcggcac 1336201 tgcaggagct gaagggcttt cgagagcggg agtcggtacg attaccatta ttgaccgtga 1336261 ctatgtggag tggagcaatc ttcaaaggca gcagctttat acagaaagcg atgccaaact 1336321 ccgcatgccg aaagccatgg ctgccaaaga gcatctatca gcgattaaca gcgagataca 1336381 tattgaggcg tatgttaccg aaggaacagc cgaaacgctt gagccgctga ttgaaaaagc 1336441 agatgtcgtg atcgacgcga cagataattt tgaaacccgc atgctgataa acgatcttgc 1336501 ccagaaaaca aagacacctt gggtctatgg cgcctgtgta agcagccagg gaatgttcat 1336561 gactgtcatt cccggagaaa ccccttgtct gtcttgtttg tttgagcaaa ttcctgtcgg 1336621 cggggcgacg tgtgatactg ccggcattat tccgcctgct gtgcatatcg tttcagcata 1336681 tcagcaggct gaggcattaa agctgttaac cggccaaaaa gaagcaatac agcgggggtt 1336741 tgtgacattt gatgtctgga acaattcgca tatgaagatt aacgttaatc atgtacgccg 1336801 tgaggaatgc ccatcttgcg gagctaatgc ggtatatcct tatcttcagg attggaacac 1336861 accaaaagct gctgtactat gcggccgtga tacagtgcag gtaaggtcag aatcattaaa 1336921 aagaatcccg aaacaggagc tcattaagcg gctgaaaaca atcggcaagg tcgaggctaa 1336981 tgcgtttttg ctgcatattt tttacgagga tttcagaatt gtcattttca atgacggacg 1337041 ggcactggtg catggaacaa atgatgtgaa agaagccaac tccgtgttgg caagagtgat 1337101 tggactgtaa caacaggagg ggtcagaatg ctggagaaaa gaacaccgat accggtagac 1337161 gaggcagttc ggcgtgtctg ccattttcaa aaacaaggtg aaacagaatg ggtggcgctt 1337221 gaagacagcc ttcatcggtt tttagccgaa gatataactg cggatcacca cgtacctgcg 1337281 tttgaccgtt cgccatacga tggttttgct gtcagagcgt gcgatacggc agaagcttca 1337341 cgtgaaaacc cagttcggtt tgaagttatt gaccatattg gagcgggagc agtatctgaa 1337401 aaagaacttg gcccgtttca ggccgtgcgg attatgactg gcgcgcaaat ccctgaaggg 1337461 gcagatgcag tcgtcatgat tgaactgact caagcctttg aggagaatgg gaagtcattt 1337521 atgtctttaa aacgccgctt tcagacgggg gataatattt caaaaacagg tgaggacgct 1337581 caaaaaggga gtgttttact gacaaagggc acccgggtga caccaggagt gacggctctt 1337641 ttggcaacat tcggatacgc atctgtgcct gtcgtgagaa agcctgtagt cgggattatc 1337701 gcaaccggta ccgaattgct gaatgtcagt gatccgctgg aaccgggaaa aatccgcaac 1337761 agcaatgcga gtatggtata tgcgcaagcg atagaagcag gcgcaacacc gctttattta 1337821 gggaaaatct ctgatgaact ggataaaagc tttgctgcag ttaaagaagc gatgaaaaag 1337881 gtggacttcc tgatcacaac tggcggtgtg tcagtcggtg actttgactt tttgcctgcg 1337941 atctatgaaa aactcggagc ggacgtgctg tttaataaag ttgccatgcg cccgggcagc 1338001 gtgacaacgg tggcgcatgc aaacgatatg ctgctgtttg gcctttcagg taatccgtcg 1338061 gcatgctatg tcggttttga actgtttgtc aaaccgataa tccagacatg gctgctcaat 1338121 gaaacaccgc attcaatttg tgcggaagct gttttgacca aggattttcc gaagccgaac 1338181 ccatttaccc gatttgttcg tgcgctcgtg caccatcagg aagggaagct gttggcgaca 1338241 cccgttggct tagataagtc gagctctgtc acatcacttg cagatgccaa tgcatttatt 1338301 atcctgccgg gcggtacgcg aggctacgaa tctggcagaa cggttcaagt gctgctcatc 1338361 agagaagaga atggaagtga atggccttgg tccgtccttt cccgatcgtc caagttgtag 1338421 gatttcaaaa cagcgggaaa acaacgttta ttgagcgcat tcttgaaaaa gcctctgaac 1338481 agggagtcca tttgggctgc ctgaagcacc atggtcacgg cggtgaaccg caaacgctca 1338541 cggaaggaaa agacacggac cgttacaagg cggcaggtgc tgatgtaaca gcggtagaag 1338601 gtgctggtgt gttacagctg actgcccgcc gcaattggga tttggcacgg ctgattgagt 1338661 tataccaatt tctcgaaaca gactgtcttc tgattgaagg ctttaaaaaa gccccttatc 1338721 ctaaagtggt tatcctaagt gaaaaggaag atctggaagc gctgcaagca gtaaatataa 1338781 tcgccatcat ctatagaaaa aaagagcata tgacagagca tcagggatta cccgtttttc 1338841 atgcggatga tccggttgcc gtggattttg tgctttcaca gctgaagggg gaatctgcat 1338901 aatggaacgg tttgagatta cgaaaacacc cattaatact gaaaacatca tcaaaaaagt 1338961 ggagaaacgg gaagcgggag ccattacaac atttattggt acggttcggg aatggacaaa 1339021 cggaaaaaga acggttcggc ttgaatatga ggcatatgaa ccgatggccg tgcaaatgct 1339081 tgctcaaatc ggcgctgaaa tcgaagaaaa atgggaaggt gcctcagctg cgatcacgca 1339141 ccgtataggt gtgctcgata tcggtgaagc agcggtagtg attgctgtat cttctcccca 1339201 tcgaaaagcc gcatatgaag ccaatgagta tgcgattgaa cgcattaaac agattgtgcc 1339261 gatttggaaa aaagaaattt gggaagacgg tgagcaatgg atcggcgacc agctagaaac 1339321 gacagcttat ccgaacggaa aaccagacct aagcgaggga gagcagcatg attaaaattc 1339381 ttttatttgc agggcttgct gaacaggccg gtacacaagc aatagaaata gatatggaac 1339441 aagcaaccac agatgaaata aaagcgagtc taaaagaaca atacggtctt gaatctattg 1339501 atacggctat gattgccgtt aacgaaagct atgtaaaaga aaatacctct gtatcttcgg 1339561 gtgacacggt agccatcata ccgccggtca gcgggggatg aaaaccggac ggcatttcag 1339621 ccgtccggtt tttctgtatt tcattggcat atccccaagt atcctcagca tacaatgatt 1339681 ttctgtaagc gtttattcta catatgttac tccctataaa gtaagagact cactccataa 1339741 ttagactgaa attttgaaaa ataatagaaa tttatttcgg gtatcgatat agtgaagatg 1339801 ataaatgttg gaaaggtgct ggatatggag acatttaaaa gattaaaaat gtattattgg 1339861 ccgtacagaa aagtgtttat gtggtcgctt ctagccatgc ttttgatgac tgcaattact 1339921 gtcgtttatc cgattatcct gcaaattacg attgatgaga tcgtactggg acggcagtat 1339981 cagcttgcgg cgtgggtcag cttaggattt attgcggtga tggttttgaa aggaatggct 1340041 accttttttc atcagtattt aggtgatatg ttcgggatca aatccgttta tcggctgaga 1340101 aatggtctgt atgaaaaact gcagcggctt tctttttctt actatgataa cgcgaaaaca 1340161 ggagatttga tgtccaggct gactgctgat gttgaagggc ttcgtttttt cttatcatac 1340221 ggtctcgctg agctcattcg cttcggcctg ctggtagcca tcagcctgtc ggttatgttt 1340281 tactattctg ttcctctcac gcttgtgaca atagctgttc tgccatttct cgcggttgcg 1340341 gtataccggt ttgacaaaag agtccatccc gccttcagag gcatccgcaa atcgtttgcg 1340401 aaactcaata caaaagttca ggaaaatatc agcggcatta atacggttaa atctctttcc 1340461 agggaagatt ttcagatcag cactttcaat aaagccaatg cagaatacag ggcgcagtat 1340521 ttacaaacat catccatttg gtctgcgtat ttccctttaa tggagttcat tggtaacact 1340581 tgtattgtag ctcttctctc atacggcggt tacttggtta tgcaaaatca gctcaatccc 1340641 ggcgagcttg ttgctttctt cagccttgtc aattatatga tgtggcccat tatgaactta 1340701 ggttttgtca tcaatatgtt ctctcaagca aaagcgtcag gggaacgcct gctcgacatt 1340761 ctggaaaaag aagaagacat tacagatcat cctcatgctt tgcataaaca aaaattaacc 1340821 ggagatgtcc atttcaaaaa tgtttctctt gcatacggaa aagaacaaac aaacgcgctg 1340881 tgcaatgtaa gctttgaggc aaacagcggg aaggtaatcg gactgttggg cccgacaggt 1340941 tcaggcaaaa gctcagtgac acagcttctc accagatttt acagtcctgt tggcggaatg 1341001 attaccattg atcacaaacc catcacagat tattcgttaa aaacccttcg ctccaatatc 1341061 ggggtcgtac ttcaagaatc cttcctgttt tcatctacga ttagatcaaa tatttcgtat 1341121 gggcggccgg atgcctcaat ggaagacgtc atcgaagcgg caaaaagggc gcaggctcat 1341181 aactttatta tggagcttcc tgatgggtat gacaccatgc tgggagagag gggaatgggg 1341241 ctttccggcg ggcagaaaca gcgtattgcc attgcgagag ccatctgctt gaacccgagc 1341301 attttaatat tggatgatgc cacaagcgca gtagatatgc aaacggagca cagcatacag 1341361 cttgccttaa aagaagtcat gaaaaaccgc acaaccttta tcgtcgctca ccgcatttct 1341421 tcactgaaac acgctgatga aattctcgtt tttaataaag gacgcattcg tgaaagggga 1341481 acacatcatg agcttcttga aaaaggcggc tactataaaa agatttacga tttgcaatac 1341541 cgtgatgtca aaatgattaa tgagccgcat gaggtcggat agggaggggc caaatgaaac 1341601 aagcgaaaaa acagggggtt ttagagcgtt tctattactc ttcagatgaa atcattgaaa 1341661 agccgtttaa ctgggctcaa atgtggcggc tgctgagcta tgtcaaacca tatcgaaaaa 1341721 caattttgcc gctttctttt ctcactgtat tgattggcac tgctgtgaag cttgtgatcc 1341781 ccattttgat cggcgtttat gttcttgatc aagcgattac agggagaaac tcggagctgc 1341841 tgattcagct catttttatt attagcggtt tatatgtcct caattacgcc gccaatgtgt 1341901 taagaatcag gtggatgaat cagcttggcc agcatgtcat ttacgatttg cgacagcatt 1341961 tatttaccca tgtgcagcgc ttatcccatc gattttttga tcagcggtcg gcgggatcga 1342021 tcttagtcag gatcatgaat gatattaact ctcttcagga gctctttaca agcggagtca 1342081 tcaatttgtt gaccgacttg ctgcttctgg ccggcgtgat tattattttg tttacgctga 1342141 gccctgagct gactatagcc atcatggtga cattgccgat tatgtttttt atttcaacaa 1342201 gtctcagaaa aaaaatacgc cgatcctggc aaacggtacg gctgaagcaa tcgaagctca 1342261 actctcatct aaacgaaagc attcagggca tccgggtcac gcaggcattt acgcaggaag 1342321 aagaaaacat ggcgtatttt gacggtgtca atcaggagaa ctacgaatca tggcgggaag 1342381 caactagaaa aaatgccatg ttccgtccgc ttgtagaaat gacgaatgcg attgggacgg 1342441 ctgtcttgat ttggtatgga gccacactca tcatgaatga aaccattacg attggcgtct 1342501 tcgtttcttt tgctttctat ctgggaatgt tttgggaacc tatttcgaga ctgggtcagg 1342561 tctataatca gctgttaatg gggatggcat catcagaacg gatttttgag tttctggacg 1342621 aacagccaaa tgtcaaggag aagccgaatg ccattcataa tgaaaagata aatggggaga 1342681 tcagttttga agaggttgaa ttttcgtatg atgaaaaacg aaaagccctt cacgccgttt 1342741 ctttctctat tcctgcggga tcgacgcttg cgcttgtcgg gcatacaggg agcgggaaga 1342801 cgacgattgc caatttaatc agccgttttt atgatgcggc cggaggcacc attaaaatag 1342861 acggtatacc gattaaggat ctttcccttg ccagtctgcg ctctcaaatc agcattgtcc 1342921 tgcaagatac atttattttc tccgggacca tcatggaaaa tattcgtttt ggaaggccaa 1342981 atgcttcgga tgaagaggtg atgaaagcgt cccaagcggt cggagcggat gagtttattt 1343041 ccgatttagc ggaaggatac gcaacagagg tagaggaaag gggcagcgta ctgtctgccg 1343101 gtcagcgcca gctcatttca tttgcaagag cattgctcgc cgatccggct attatcatcc 1343161 ttgacgaagc aacggcaagc attgatacag agacagaagt aaaaattcag caagcgttaa 1343221 aaacgcttct gaaagggcgt acagcagtga tgatcgctca cagattgtct acgatccgcg 1343281 acgccgaccg catcattgtt cttgatcacg gcaggaaaat agaagaaggg aaccatgatc 1343341 agctgctcgc taaaggaggc atttatgccg ggcttgtgaa agcgcaatac agcacagcga 1343401 tagaataata tgaaaagcct tcaatattga aggtttttgg aaatttatta gaaaaacatg 1343461 aaactttttg atatccttcc cgtactattt gttagatatt ctcaaggagg ttttgaaatg 1343521 gaaacgaatg tagaaaaaaa cagcggaacg gcgactgaaa agccttcact tttcggagta 1343581 atcacaagtc cgtccgttca atttgaaaga ataagagaaa ggccggctgt atggggaccg 1343641 cttttgattg ttgcagcaat tatcatcgtc ggtgccgtgc tgcaatcact cggtacggat 1343701 tatagtgagc ttttgaaaag ccaggatacg caagggctat ctgctgaaca aatggaaact 1343761 gtcgcaacaa taaccaaatt tggcggaatg gcaggcgcta ttatcggcgg tatcgcagca 1343821 ttatttattg cccctcttat ttattggctc tgtgtaaaag tatcaggcgg tgttacgaca 1343881 tataaaaaaa tgctttctct cagtctgttt gtctctttga ttagcagtct cggattattg 1343941 gttaatggaa tcgttgcttt tacgactgac gtgaatcctc tttacagcac gacgtcactc 1344001 gcagggatta tcccatctga cggggctctc gccagtgtgt taaatacctt tgaaattttc 1344061 agcatctgga gctttgtatt attagcaatc ggacttcaca aaacgggagg catctcaaaa 1344121 aaagccgggt ggatttcagc aatcattcta ttcggaattt tagttgtatt ttcgcttttt 1344181 tcaggtttaa tcaattctgt ggcgggtgca taagctcatg aaaaaagtct ggatcggaat 1344241 tggaatcgca gttatagtcg ctctttttgt tggaatcaat atataccggt ctgccgctcc 1344301 gacaagcggc agcgccggca aggaggtaca gacggggagc gttgaagaaa atgaaatctc 1344361 atcaacggtt atggttcctg gcacgctaaa attttcaaat gaacagtatg tcttttatga 1344421 agcggataaa gggacattag aagacattaa agtaaaggaa ggcgataaag ttaaaaaggg 1344481 cacggcttta gtcacctata caaatgagca gctgagcctg gaaaaagaac agaaccagtt 1344541 aacgtctgaa tccaaccggc ttcaaattga ccaaattcaa gaaaagttaa aagccttgga 1344601 cagcaaagaa agagaactgg aaaaacaggt aggaaagaaa gaagcagaaa aacaaatcga 1344661 atctgaacgg acagagcttc aaatgcagaa aaaaacagcg gagatcgaat taaaacaaac 1344721 cgagcttcag cggcagtcac ttgccaaccg ggtgtcagat ttagaagtga aaagcgaaat 1344781 tgaaggcacc gttatttctg tcaaccaaga agcggcatcc aaaaagtcag atattcaaga 1344841 gcctgtcata catatcggca acccaaaaga ccttgtcgtc tcagggaaat tgtctgaata 1344901 cgatacattg aaagtcaaaa aaggccagaa ggtcacactc acttcagatg taatacaggg 1344961 taaaacatgg aaaggcacgg tttccgcagt cgggcttgtt ccggatcagc aggagagcgc 1345021 tgcggcacaa ggaacagaac aggcggtcca atacccgctt caagtgaaaa taaaaggaaa 1345081 tcttccagaa ggaaagccag gctttaaatt tatcatgaat attgaaacag ataaacggaa 1345141 agcaaatacg cttccttcaa aggcagtcaa aaaagaagat gaccaatatt atgtgtatac 1345201 agtaaaagac ggaaaagcaa agcgagttga tgtcaaaatc ggcgaagtga cagatgacct 1345261 gacagaaatt aaagaggggc ttacccaaga tgatcaagtc attttgaatc catctgatca 1345321 ggtgactgac ggaatggaag tgaaatccta aatgattcag ctttctaatg tgcgaaaaag 1345381 ctaccagatc ggaaaggaaa cgtttgatgt tctccattct attgatttgg acattcatca 1345441 aggtgaatat gtctcgatta tggggccgtc aggatcagga aaatcgacga tcatgaatat 1345501 tatcggctgt cttgatcggc cgacttccgg tacatatcaa ttggacggcg aagacatttc 1345561 ttcatataaa gataaagaac tggcggcagt ccgtaaccgg tccatcggtt ttgtatttca 1345621 gcaatttcag cttcttccgc ggctgaacgc aaaaaaaaat gtcgagctgc cgatgattta 1345681 ttccgggata ggcaaaaagg aacgtcaaga gcgggctgag agagcattgg aaaaggtcgg 1345741 gttagccgat cgaatgctcc acatgcccaa cgagctgtcg ggcgggcaga agcagcgggt 1345801 ggcgattgcg agggcgatcg tgaatgagcc gaaattgatt ttagctgatg aaccgaccgg 1345861 cgcgctggat acgaaaacaa gcgaggcgat tatggatcag tttacagcat taaatgccga 1345921 gggaacgaca atcgttctgg ttactcacga gcctgaagta gcagattgca cgaatcggat 1345981 cgtcatggtg cgtgacggaa acattgttcc tgccagctcc ggacaaagga gtgtgggaga 1346041 atgagcctgt tggaaaacat cagaatggct ctaagctctg tccttgccca taaaatgcgt 1346101 tcgatcttaa cgatgctcgg cattatcatt ggtgtaggct ctgtcattgt tgtcgttgcg 1346161 gtaggacagg gcggcgagca aatgctgaag cagtcgatca gcggcccggg aaatactgtg 1346221 gagctgtact atatgcctag cgacgaggag cttgcaagca acccgaatgc cgcagctgaa 1346281 tctacgttta cagaaaacga tattaaaggt ttaaaaggaa tagaaggcat taaacaagtc 1346341 gttgcttcga cttctgaaag tatgaaagcg cgttatcacg aagaagaaac cgatgctacg 1346401 gttaacggaa taaatgatgg atacatgaat gtcaattctt tgaaaatcga aagcggcaga 1346461 acctttaccg acaatgactt tctcgcgggg aatagagtcg gaatcatctc tcaaaaaatg 1346521 gctaaagagc tgtttgataa aacctcccct ctaggtgaag ttgtctggat taacggacag 1346581 cccgttgaaa ttatcggcgt gctgaaaaaa gtaacaggct tgctttcttt cgatttaagt 1346641 gaaatgtatg tgccatttaa tatgatgaaa tcctcttttg gcacaagtga tttcagtaac 1346701 gtatcattgc aggtcgaatc agcagacgac ataaaatcgg ctggaaaaga agcggcacag 1346761 ctggtaaatg acaatcatgg cacagaggat tcgtatcaag tgatgaacat ggaagagatt 1346821 gcggccggaa ttggcaaagt aactgcaatt atgacgacga ttatcggctc aattgcaggt 1346881 atttcccttt tggtcggcgg aatcggtgtc atgaatatta tgctcgtatc agtcacagaa 1346941 cggacgcggg aaatcggaat cagaaaatca cttggtgcga cgaggggaca gattctgact 1347001 cagtttttaa ttgaatcagt cgtattgacg ctgattggcg gtctggtcgg gattggtatt 1347061 ggatacggag gggccgcgct tgtttcagcc attgcgggct ggccgtcact catatcctgg 1347121 caggttgtat gcgggggcgt gctgttcagt atgctcattg gtgttatttt cggcatgctt 1347181 cctgcaaata aagccgcaaa gcttgatccc attgaagcgc tgcgttatga gtagcctcat 1347241 gcaacatgca tgaggttttt ttatgtttag tgatttctac tatgaatata aaagactttt 1347301 ttcattaaaa taagaagaaa atgtcgtaca attgtcctta tttttgtcga atttacagtt 1347361 tacaaaccct atagacatac gttaatatgg agaaacgtga aagattttga tagttattga 1347421 atgaatttga atgattttag ttgcctaaac cgaaaatagc gtttacaatg aaattgtatt 1347481 caaaatgaat acgttttcat taggaggtga agcatgctaa ctcctgaacg gcatcaattg 1347541 attattgatc aaatagaaaa gcatgatgtg gtaaagattc aagagcttat aaatctgact 1347601 aatgcttctg aatcaacaat cagaagagat ttatcgaccc ttgaagaacg cggtttttta 1347661 aagcgcgttc atggtggagc ggccaagctt tccgatatca gacttgaacc cgatatgctt 1347721 gaaaaatcat ccaaaaacct tcacgataaa ctgaagattg ctgaaaaagc tgcttctctt 1347781 ttagaagaag gggattgcat ttaccttgat gcaggcacga cgacattgca catgattgat 1347841 tttatggata aaaccaaaga tattgtcgtt gtcacaaacg gggtaatgca tatcgatgca 1347901 ttaataagga aagaaatttc tttttatctg cttggaggat acgtaaagca cagaacgggc 1347961 gcgattattg gaggcgcttc attggttgcc atggaccagt acagatttga caagagtttt 1348021 ctggggacaa acggtgtcca tacagaggct ggatttacaa cgccggaccc tgatgaggcc 1348081 cttttaaaac agaaagcgat caaacaggca aaacacgctt acgtcttagc agacccttcg 1348141 aagttcggag aaatttcatt ttcggcattc gccggaatag gcgacgcaac aatcattacg 1348201 actgacgctg aagagcttac attcgataat taccaagaaa aaactgtcgt aaaggtagtg 1348261 aaaccatgat ttacactgta acacttaatc catctgtcga ttatatagtt cacgttgaag 1348321 attttactgt aggaggcctg aaccgttctt cgtatgatac caagtatcca gggggcaaag 1348381 gcatcaacgt atcgagactg ctgaaaagac accatgtggc gtctaaagcg ctcggattcg 1348441 tcggcggatt taccggagaa tatatcaaaa catttttacg ggaagaaaac ctggaaacag 1348501 ctttttctga agtaaaaggg gatacccgta tcaatgtaaa gctgaaaacg ggtgatgaaa 1348561 ctgaaattaa cgggcaggga ccgacaattt cggatgaaga tttcaaagcc tttttagaac 1348621 agttccaatc tttgcaagag ggagatatcg ttgttcttgc aggaagcatt ccatcttcac 1348681 tccctcacga tacttatgaa aaaatcgcag aggcctgcaa acagcagaac gcacgagttg 1348741 ttctggatat ctcaggcgag gctcttttga aagcaacaga aatgaaacca tttttgatga 1348801 agccaaatca tcatgagctt ggagaaatgt tcggcacggc cattacatct gttgaggaag 1348861 ccgttcctta tgggaaaaag cttgtagaac aaggcgctga acatgtaatc gtatcaatgg 1348921 ccggagacgg agcgcttctg tttacgaacg aagctgttta ttttgctaac gtgccaaagg 1348981 ggaaattggt aaactcagtc ggagcagggg attccgttgt tgcaggtttc cttgccggaa 1349041 tttccaaaca gctgccgctt gaagaagcat tccgcttagg agttacttca ggcagtgcta 1349101 ccgcgttctc tgaagaactt ggaacagaag aatttgtcca gcagcttctt cctgaagtta 1349161 aggtcacacg tctatagagg aggaaacaca agtgaaaata actgagcttt taacgaagca 1349221 tacgataaag cttaatattg agagcaaaga aaaagaaaat gttattgacg aaatggtcac 1349281 tgttcttgat aaggctggaa agttaaatga ccgacaagcc tataaagaag ccattttaaa 1349341 tcgcgaaagc caaagctcca cgggtatcgg tgaaggaatc gctatccccc atgcgaaaac 1349401 ggcaagcgtt atcaacccgg cgatcgcgtt cggacgttca aaagacggcg tcgattatga 1349461 atcattagac ggccagccgg ctcacttagt gttcatgatc gcggcgactg aaggcgcaaa 1349521 caacactcac cttgaagcat tgtcaagact ttcaacgctg ttaatgcgtg aagaaatccg 1349581 taagcagctc cttgaagctg agtctgaaga tgccatcatc gacattatta atcagcacga 1349641 taaagatgat gacgaagagg aagaggaaga agaagcggca ccagcacctg ccggaaaagg 1349701 gaaaatttta gcggttactg catgcccgac aggtattgcc catacattca tggctgcgga 1349761 tgcccttaaa gaaaaagcga aagagcttgg tgtggaaatt aaggtcgaaa caaatgggtc 1349821 aagcggcatt aagcacaagc tcactgccca agaaatcgaa gatgcacctg caatcattgt 1349881 cgcagcggac aagcaggttg aaatggaacg ttttaaaggc aagcgcgtac ttcaagttcc 1349941 tgtaacggcg ggtatcagac gtccgcaaga gcttatcgaa aaagcgatga atcaagatgc 1350001 gccgatttat caaggcagcg gcggcggttc agcagcttca aatgatgatg aagaagcgaa 1350061 aggcaagtct ggaagcggta tcggaaacac gttttataag cacctgatga gcggtgtcag 1350121 caacatgctt ccgttcgtag tcggcggcgg tattctcgtt gcgatttcat tcttctgggg 1350181 aattcactct gctgatccga atgatcctag ctacaacacg tttgcagcag cattaaactt 1350241 tatcggcggc gacaatgcat taaaactcat tgttgcagtt ctggccggtt tcattgcgat 1350301 gagtattgca gatcgtcctg gttttgcgcc tggtatggtc ggcggattta tggcaactca 1350361 agcgaatgct ggattcttag gcggcttaat tgccggattc cttgccggtt atgtcgtgat 1350421 tttactgaaa aaagtattta cgtttatccc tcagtcactt gatggattaa aacctgtttt 1350481 gatttacccg ctgttcggta tttttatcac tggcgtatta atgcaatttg tcgtcaatac 1350541 acctgtagcg gcatttatga atttcttaac aaactggctt gaaagccttg gtactggaaa 1350601 ccttgtgtta atgggtatta tcttgggcgg catgatggcg atcgatatgg gcggtccgct 1350661 taataaagca gcctttacgt tcggtatcgc catgatcgat gcaggcaact atgcgcctca 1350721 tgcagcaatc atggccggcg gtatggttcc tccgcttggt atcgcacttg caacaaccat 1350781 tttcagaaac aaattcactc agcgtgaccg tgaagctggt attacatgct atttcatggg 1350841 agctgctttc gtaacagagg gagcgatccc atttgctgcg gctgatccgc ttcgcgtcat 1350901 accagctgct gtagtcggtg cagctgttgc cggcggatta actgaattct tccgagtaac 1350961 gcttccggcg cctcatggag gagtattcgt agctttcatt acaaaccatc cgatgcttta 1351021 ccttttaagt atcgtgatcg gtgctgtcgt gatggcaatt atcctcggta tcgtcaaaaa 1351081 acctgttaca gaaaaataag aaaaaaagcg tccttggttc gaaaggacgc tttttcttat 1351141 ccggccggca gggagcgcgg ttaagttatg tattttattc ttttttatga taaagtaaaa 1351201 gaagagaaac aactgacata gcaattgtct aggaggaaac actttgaccg aggaaaaaaa 1351261 tacgaatact gagaaaacgg cgaagaaaaa aaccaatacg tacctggaat ggggtaaagc 1351321 gattgtcatc gctgttctgc tggctctcct gatccgtcac tttttgtttg aaccgtattt 1351381 agttgaaggt tcatctatgt atcccacatt acatgacgga gaaaggctgt ttgtgaataa 1351441 aacagtcaac tatatcggcg agctgaagcg cggagatatc gttattatca acggtgaaac 1351501 ttctaaaatc cattatgtaa aaagattgat cggaaagcct ggagaaaccg ttcaaatgaa 1351561 ggatgacacg ctttatataa acggtaaaaa agtagccgag ccttacttgt ctaaaaacaa 1351621 gaaggaagca gaaaaacttg gtgtcagtct gacaggagac tttggaccgg ttaaggttcc 1351681 gaaaggcaaa tactttgtca tgggagataa ccggctgaat tctatggaca gccgaaacgg 1351741 gctgggactg atcgcggaag atcgaattgt cggcacatcg aagtttgtct ttttcccgtt 1351801 taacgaaatg cgtcaaacaa aataaaaacg ccttgctggc ctaggacagc aggcgttttt 1351861 attttgaaaa agaagcgacc aatgcaatgc ataaaaccgt gatgaacact gaaccgataa 1351921 tagccagcac actgaagaaa aggtgaacct gtttgttctc ttttccgcgc ttttctaata 1351981 gccgtttaga aaaaatgtgc gaaaatatgt aaataagggc tatgcctata tataagccga 1352041 tatctttggc ggtaaagcct gttacggcaa ggtaaaagcc cgtaaaaaag atcagtaagc 1352101 aatattcagt aagtgttaaa agcctcaacg tgttcctcca tgagagtgtg taattttcca 1352161 ggcggatgca ttctctctct ttaattgtaa cacagctggc tggtttgggt gtataagtgt 1352221 tttctctctg ttttatcagg gaatcatttc tcttgccctg cattcatggt atacttttat 1352281 tgatgataga catgatggag gataataaat gattgctgta aataatgtaa gcttgcggtt 1352341 tgcggatcgc aagttatttg aagatgttaa tattaaattt accccaggca actgctatgg 1352401 gttaattggt gcaaacggtg ccggtaaatc aacgtttcta aaggtgctgt caggcgaaat 1352461 cgagcctcag acaggcgacg tgcatatgag tcctggcgag cgtcttgccg tcttgaagca 1352521 gaaccatttt gagtacgaag agtatgaagt gctgaaagtg gtcattatgg gccacaaacg 1352581 cctgtatgaa gtcatgcagg agaaagacgc tatttacatg aagcctgatt tctcagatga 1352641 ggatgggatt cgtgctgctg agctagaagg tgaattcgcg gaactgaacg gttgggaagc 1352701 ggaaagtgaa gctgcgatcc tgttaaaagg ccttggtatc tcagaagatc tgcacacaaa 1352761 aaagatggca gacctcggcg gttcggagaa ggtaaaagtt ctcttggcac aggcattatt 1352821 cggcaagccg gatgttctgc tgctcgatga gccgacgaac cacctggacc ttcaggcaat 1352881 tcagtggctt gaagagtttc tgattaactt tgaaaacaca gttattgtcg tatcccatga 1352941 ccgtcacttt ttaaataaag tatgtacgca cattgccgac cttgatttta acaaaattca 1353001 aatctatgtc ggaaactatg atttctggta cgagtcaagc cagctggcgt taaagctttc 1353061 tcaagaagcg aacaagaaaa aagaagagca gattaaacag cttcaagagt ttgtcgctag 1353121 attcagcgcc aatgcgtcta aatctaagca ggctacatca agaaagaaac ttctcgaaaa 1353181 aatcacgctg gatgatatta aaccgtcttc ccgccgctat ccttatgtta acttcacgcc 1353241 ggaacgggaa atcggaaatg atgttcttcg cgtggaaggc ttaacaaaaa caatcgatgg 1353301 cgtaaaggtg cttgacaatg tcagctttat tatgaatcga gaagataaaa ttgctttcac 1353361 tggccgaaat gaacttgctg ttactacgct gtttaaaatc atttccgggg aaatggaagc 1353421 tgacagcgga acgtttaaat ggggtgttac cacatctcaa gcgtattttc caaaagacaa 1353481 cagcgaatat ttcgaaggca gtgatctgaa ccttgtagac tggcttcgcc aatattctcc 1353541 gcacgaccaa agtgagagct ttttacgcgg tttcttagga cgcatgctgt tctctggaga 1353601 agaagtccac aaaaaagcaa atgtactttc cgggggagaa aaggtccgct gtatgctgtc 1353661 gaaagcgatg ctttctggcg ccaatatttt aattttggat gagccgacca accatttaga 1353721 cctagagtcc attacagcgc tcaataacgg cttaatcagc tttaaaggcg ctatgctgtt 1353781 tacttcccat gaccatcagt ttgtgcagac cattgccaac agaattatag aaattacacc 1353841 taacggcatc gtcgataagc aaatgagcta tgacgagttc cttgaaaatg ctgatgtgca 1353901 gaaaaaattg actgaactat acgccgaata aaaaagcaga gatttctctg ctttttttga 1353961 tacctaaatg tgaaaggaga tcacaacatg aaatttttgg ttgtcggagc aggtggagta 1354021 ggcgggtata ttggcggacg gctttcggag aaaggaaatg atgtgacatt tctcgtgcgc 1354081 caaaaacgag ctgagcagct taaaaaaacc gggcttgtca tccatagtga aaaagggaat 1354141 gtatcatttc agcccgaact aatcagtgcc ggagaaacag ggcaatttga tgtcgttatc 1354201 attgcttcta aagcatactc gcttggtcaa gtgatagagg atgtcaaacc atttatccat 1354261 caagaatctg tcattatccc ttttttaaat gggtaccgcc actatgagca gctatttgcg 1354321 gcattttcaa aagaacaggt gctgggcggc ctgtgtttta tagaaagtgc tttagacaac 1354381 aaaggagaaa ttcatcatac gagcgcatcg catcgttttg tatttggaga atggaacggc 1354441 gagcgtacgg agcggataag agcgcttgaa gaggcatttt caggtgtgaa ggctgaagtc 1354501 atcattagcg ggcatatcga gaaggacatt tggaaaaagt atctctttat tgcagcgcaa 1354561 gcggggatca caacgttatt tcaacgaccg cttggcccaa tcctcgccac agaagccgga 1354621 cgtcacacgg cccaaactct tattggggaa atttgcactg ttttacgaaa agaaggtgtt 1354681 ccggctgatc cggctcttga ggaagagagc tttcgtacga tgaccagcat gtcttaccat 1354741 atgaagtcct ccatgcttcg ggatatggaa aacggccaaa cgacagaagg cgaccacctg 1354801 catggatttt tgattgaaaa agcaaaacgt ttatctctcg ctgcaccagt attagaaacc 1354861 gtttatgcga atctgcaaat gtatgaagca gaaaaataaa aaaaggaggc ggaaaagcct 1354921 ccttttattt acttaaaaag cccaatttcc gtttctgaag ataggctctc ttttcccgtc 1354981 tgccgtaatt ccgtcaatat tcatatcctt agaaccgatc ataaagtcca cgtgtgtaat 1355041 gctttcattt aggccttctt tgacaagctc ttcacgagac atctgctttc cgccttcaat 1355101 attaaaggca taggcgcttc cgatcgccaa atgatttgac gcgttttcat caaacagcgt 1355161 gttatagaaa agaatgtttg attgtgatat aggcgaatcg taaggaacaa gtgccacttc 1355221 acctaaatag tgagaacctt catctgtttc caccagttct tttaaaatat cctcaccttt 1355281 ttcagcttta atgtcgacta tacggccatt ttcaaacgtc agggtgaaat tttcaataat 1355341 atttccgccg tagcttaatg gttttgtgct tgataccact ccgtcaaccc cgtctttttg 1355401 cggcagcgtg aacacttctt ctgtcggcat attggccata aactcatggc cactttcatt 1355461 cacgcttccc gcacctgccc aaacatgctt cctaggcagc ttaattgtta gatcagttcc 1355521 ttctgcttga taatgtaagg cagcgtaatg tctctcgttc aaatggtcaa ctttttcatg 1355581 aagattttgg tcatgattga tccacgcctg aaccgggttg tcttcattta cgcgcgtcgc 1355641 tttaaaaatt tcttcccaca gaaggtggat cgcttcctcc tctgatttgc caggaaacac 1355701 cttgtgagcc cagcctgctg atgccgcacc tacgacagtc cagctgactt tgtctgattg 1355761 aatatattgt ctgtatgtat gtaatgcttt gcctgctgct ttttggaatg ccgcaatccg 1355821 tttggaatct atacctttta gcaagtctgg gttcgacgac acaacagaaa tgaaagcagc 1355881 tccatttttg gcaagctctt ctctgccttt tgcttcccat tcaggatatt cttcaaatgc 1355941 ttcaaacggc gcaagttcgt attttaattt ggcgacttcg tcatcctgcc aattcacggt 1356001 gacgtttttt gcgccctttt catatgcgtg ttttacaatt aaacggacaa aatcccgaac 1356061 gtctgttgaa gcatttacga ctacatactg gcctttttgg acattaacgc cgacttctac 1356121 cgccagctgt gcatatgtat ttaatttctg tgaaaatgaa tccatgaatc attcctccaa 1356181 gcttttttct catcatatca aatatgatcc tataaaggaa agaaggagcc caaagtgaaa 1356241 aacccaaaac gacacgtctt gggttttttc aatattatgg atgattcagt tttacagtgc 1356301 cgcctgcagg cgaatggggc atatttgcca aagaaatgct catgcctcca agaataattc 1356361 cgcttaaaat ggctgcgatc gctactcttc ttcctaaatc tcttagcatc tgtttcctcc 1356421 ttaacgtttc tccatttccc acaatatgaa ggaagtgagg aaaaaagaag caagaaattt 1356481 gccgcgtgtg agaattttgc gggtaaagac tatttaattg ccttttgcag cttatcaatc 1356541 acttctaaag aacggcctgt gccgattgct acagattcaa gcgggttttg cgccacgtgt 1356601 acaggcacga caatctcttc tgtgagccat tctttaattc cattaaggag cgcgccgccg 1356661 cctgttaaaa taacgccgcg atcaacaata tctccgctca attcaggcgg acagtcctca 1356721 agtgtcgctc tgatggcttc aagaatatgc aggagggatt cacgcattgc atcttgaatt 1356781 tcgttggatt gaagcataat ggtttttgga agacctgtca cgaggtcacg tccccgaatt 1356841 tccattgcct ctggtatatg ttcaatcaga gcatggccaa tttccatttt tacctgctca 1356901 gctgtgcgtt cgccgatcag caaattgtat tttttacgga cgaaagaaac gatatcctca 1356961 tcaagctggt ctccgccgat cctgatagaa tggcaggaaa caacgccacc gaaggaaata 1357021 atagcgacct ctgtcgtccc tccgccgata tctactacca cattggcaac cggctcatca 1357081 accggtaaat ccgctccgat ggcggctgca actggctctt cgattaaatg aacgtttttc 1357141 gcgccgcaat ttttcaccgc atcactgatg gcgcggcgtt ctactgctgt tgagcctgat 1357201 ggtgtgcaaa cgactacgtt cggttttctg aacgacatgc cgatgctttt tgcggctttt 1357261 ttcataatgt gctttagcag gtcagttgtc atatcatagt ctgcgatcac gccatctttc 1357321 atcggtctga cagcgacaat ttttcccggt gttttaccga tcatgttttt cgcgtcagct 1357381 ccgattgcaa gcactgcttt tgtcgtcgta tccactgcga caacagatgg ttcatttagg 1357441 ataatccctt tatttttgct gtaaacaagt atattagctg ttcctaagtc aatcccgatt 1357501 tcagttgatt gaaacatgtt ttcacccaat ctctatccta atttaatatg attctacatt 1357561 taaagtttct cagaaatact gcgatttttg ggggtgtgcg tcggtaaaga aatgtttttg 1357621 taaaaaatca aggaactgtg taacagaagt aatacatttt tcggttttat ggaaaaaata 1357681 tcttgtaatt cttatagaaa gcgggaaact ttttcaaagt ttcattcgtc tacgatatat 1357741 tgaggtacat ccttaaaaca ttacatgaga aaagaaacat ttaaaggaag aagggttttt 1357801 atgaaatcaa taggtgttgt gagaaaagta gatgaattag gccgcattgt catgccgatt 1357861 gagttgagac gggcattgga tattgccata aaagacagca ttgagttttt tgttgacgga 1357921 gataaaatta tcttgaaaaa gtacaaacct catggcgttt gtttaatgac tggagaaatc 1357981 acttcagaaa ataaagaata cggcaacggt aaaattacgc taagccctga gggtgcacag 1358041 ctgcttctcg aagaaattca agccgcttta aaagaataaa attatgctaa aaaaggcgga 1358101 gtgatatcat ctccgccttt tttgcgtgcc aatttttgat taccgccgcc taagataaga 1358161 catcaagata tttggtaatg aatgatttgg gatactttac atattttact caattatttg 1358221 tcgaagaatg gtacaataag tagagaaaca caagcggcag gtggtcatat gagaaaatat 1358281 caagctcgta tcatttccat cattttggca atgattttta taatgttttg ggattattta 1358341 ttttatttta taggcaaaaa cccgattaat tggcctgttg atattgtgta tactgcagtc 1358401 acgctggtaa gtgtctggat gttggcttat tatattgatg agaaacagca gctggttaag 1358461 aaaatgaagg ataacgaatg gaagtataaa cagctttctg aagaaaaaaa ccgcatcatg 1358521 gataatttgc aggaaatcgt atttcaaacg aatgcaaaag gtgaaattac atatttaaac 1358581 caagcgtggg catctataac cgggttttca atcagtgaat gtatgggaac aatgtataac 1358641 gattacttca taaaagaaaa gcacgtagcc gaccacatta acacccaaat ccaaaacaaa 1358701 gcgtcttctg gcatgtttac ggcaaaatac gtgacaaaaa acggcacgat tttttgggga 1358761 gaagttcatt ataaacttta ctatgaccgg gatgaccaat ttacaggcag cctgggtaca 1358821 atgtcagata tcactgagcg gaaagaggct gaagatgagc tcattgagat taatgaacgg 1358881 ctggcgaggg aatcccagaa actatcaatc acaagtgaac ttgccgcagg tattgctcat 1358941 gaggtcagaa accctttaac atctgtcagc ggtttcctcc agattatgaa aacacaatat 1359001 ccggacagaa aagactattt tgacatcatc ttttcagaga ttaaaagaat cgatttagtg 1359061 ctcagcgagc tgctgctgct tgcaaaaccg caggcaatca catttaaaac acaccagctt 1359121 aatgagatct tgaaacaagt cacgacattg cttgatacca atgcaattct gtccaatatc 1359181 gtcatagaga aaaatttcaa agagacagat ggctgtatga ttaatggaga cgaaaatcag 1359241 ctgaagcagg tctttatcaa catcattaaa aacggaattg aggcaatgcc aaagggcggt 1359301 gtcgtaacca tttcaactgc taaaaccgcc tctcatgcag tgataagcgt aaaggatgaa 1359361 ggaaacggca tgccgcagga aaagctgaag cagattggca aaccttttta ttcaacaaaa 1359421 gaaaagggca ctggactggg acttcccatt tgtttgagaa tcctgaagga acatgacggg 1359481 gaattgaaaa tcgaaagtga agctggaaaa ggcagcgtct ttcaagtggt tttgccttta 1359541 aaatcagaca gctgagagga gaaaaataaa gtgaactcgc ttctgtttgt atacgggaca 1359601 ttaagaaagc atgaaaaaaa ccatcatttg ctggcacaat cggcatgtat caatgagcag 1359661 gcgagaacaa agggaagttt gtttgctgca aaagaggggc ccacagttgt tttcaatgat 1359721 gaagatgaag gctatatata tggcgaagta tatgaagcag atgaattgtg tatacataag 1359781 ctcgatcaat tttttcaagg atatcataaa caaacggtgt ttgtagaaac ggatgtcggg 1359841 attaaaattg cgcttattta ttttatgaac aaagacgggt gtgccggttt tacgaaaata 1359901 agcagcggcg actggaaaga acatcagatg atcagcaaat cgaaaaatcc catttattat 1359961 tttgcctatg gatcatgcat ggataatgcc cgctttcaaa aagcgggagt cgatcactat 1360021 tttcaagatc cagtaggaag agctgtttta aaaggataca caacccgctt cacgctaaaa 1360081 agggaagacg gttcaagagc ggacatgttg gaagacggag gaacaacaga aggcgtttta 1360141 taccgtatcc cttattctgc tctctcctat ctatataaaa gggagggcgt cgaatctctt 1360201 acgtatcggc cggcatttgt agacgttgaa gctggcggaa ggcactacaa agactgttta 1360261 acctttctcg tcctccaaaa agaagcggaa attgccccgc ctcagcacta tcagattgaa 1360321 atcgaacgcg gagcggagct gtatttgtcg cctgagttta ctgaaaagct caagcggcat 1360381 atgaattcgc tgccaaaagg ataacactgt aacaaaagaa tatgataaaa tttgatcaat 1360441 atcatgtcat ataaaggagc accacgatga aaaaagaatt tgcggtaatt gggctgggcc 1360501 gttttggtgg cagtatttgc aaagcattaa gcgaagaagg cgtcgaggtt atggcaatgg 1360561 atatcgatga agataaagtc aacgagtatg ccaagattgc atctcacgca gttatcggtg 1360621 attcgacaga cgaatctgtc ctgaaaaatt taggcctgcg aaattttgac cacgttattg 1360681 tagcaatcgg ggaaaatatt caagcgagta ttttaacgac actcattctg aaagaacttg 1360741 gcgtccatac gattacagtt aaagcgcaga acgattatca cgaaaaagtg ctgtctaaaa 1360801 ttggtgcgga tcacatcgtc cacccggaac gcgatatggc aaaacgaatt gcgcataata 1360861 tcgtgtccaa caatgtactt gactatttgg agctgtctga agagcatagt cttgttgaaa 1360921 tcgtagctaa cagccgcctg gctggaaata cgcttctcga tttagatatt cgcgcaaaat 1360981 acggtattaa catcgtagcc ataaaaaggg gcaaggaagt catcgtatca ccgcttgcaa 1361041 ccgaagtcat ccaccaagaa gatatactca ttgttattgg atcagttaca gacatctccc 1361101 gtttcgaaaa aagagttctt catacaaaat agcagccaaa taagccgtcc tcaaagggcg 1361161 gtttttcata ttatcagaat ataacaactt taatgaactg agcgtcaatt tcttaaaatt 1361221 tcattgacta agcacaggcg ttccgatagc atattgtacc atataataaa aaaaggaggg 1361281 gcctatttga ataaagaagc gctagtcaat aggctgaatg cttcagccaa aagacaaaaa 1361341 gctgatatcg tcattaaaaa cggaaaaatc atggacgtat ataatcaaga atggatatat 1361401 gaagatattg cgattacaga tggagttatt gtaggcctcg gtgagtatga aggcgaaaat 1361461 atcattgatg cagagggaca aatgattgtt ccgggtttta ttgatggaca tgtacatatt 1361521 gagtcgtcaa tggttacacc gattgagttc gctaaagcag tgttgcctca tggcgtgacg 1361581 acggttgtta cagatccgca tgagatcgcg aatgtgtctg gtgaaaaagg gattgagttt 1361641 atgcttgaac aagctcggca tacaccgctg aatatccatt ttatgcttcc ttccagtgtg 1361701 cctgccgcaa gttttgagcg atcaggcgca attctcaaag ctgccgatct caagcctttt 1361761 tatgaagaag aagaagtatt agggctggct gaagttatgg attatgtgtc ggttcagcag 1361821 gctgaaaaag acatggttca gaaactgctt gatgcccgtg tggcaggaaa aaggatagac 1361881 ggtcatttag ctggtttatc aacagacctc attaacattt acagaaccgc atttgtctta 1361941 aacgaccatg aagtaacatc gaaggaagaa gcccttgatc gtatcagaag gggcatgtat 1362001 gtcatgatgc gtgaaggatc agtcgccaaa aacacgctca atgtgctgcc ggcggtgaat 1362061 gaaaagaacg cacgccggtt ctttttctgt acggatgata agcatgtgga tgatttattg 1362121 tcagagggaa gtgtaaacca tcaggtgaaa atggcgattc aagccggact taatccgttt 1362181 ttagcctatc agctaggaag cctcaatgca gccgaatgct acggattaga tacaaaggga 1362241 gcgattgccc cgggttttga cgctgatttg ctttttgtat ctgatctgga aaatgtcact 1362301 gtcacaatga cgatggtaaa agggcagact gttgctgaag acagcaaagc ggtctatcag 1362361 gatcatgctt caactgcagc accagatcag gcactgcttg attctgttaa gcttgctgct 1362421 cctcttaaca aacaggattt tcatatgcca atcgattcag agcagcagat caatgtcatt 1362481 caaatcatac caaatcagct tgaaacacga ttagtacaag ttccggctcc tgttgcccgc 1362541 gaatttgagc ctgacactga gcttgatttg ttaaagattg cagttgtcga gcggcataaa 1362601 ggattaaaag aaaccggact tggtgttgtg aaaggttttg gattcaagag cggagcgatt 1362661 gccacaacca tttcacacga ctcccataat attattgccg tcggaacgaa tgatgaggat 1362721 atcgcggcgg cagttaataa gctgcaggaa attggcggag gattaacaat tataaaaaat 1362781 ggggaagagc tccattcagt accgctgccg attgcagggt tattatccga ccaatctgca 1362841 gagcaagtga atcaaagctt gctgacgctt catgataaat tgtcgttaat cggtttcaca 1362901 ggcggattta atccattttt gacattgtcg tttttagcgt tgcctgtcat tcctgatatt 1362961 aaaatgacga ctacgggatt attcgatgta aaatcatttc aacacatatc actgcaataa 1363021 aaagaggcac tcccttaggg agtgcctctt tttttaaacc tccataatga tcggcaggat 1363081 cattggacgg cgctttgttt tttcgtacaa gaaaggtgca agcgtgtctg taatttcgtt 1363141 tttgatttca gaccattgag tcgtttttcg ttccattact ttttgtaagt gatttgaaat 1363201 gagctcttga gcgtcgttga tcaagtcacc agattctctc atgtacacaa atcctctgga 1363261 aatcaaatca ggacccgctg aaatcttgaa gtcgtccatg tcaatgctga caacaacgat 1363321 gacaagtcct tcttcagaga gaattctgcg atcacgaagt acgatattgc caatatcacc 1363381 gataccgctt ccgtcaatgt acactgaacc ggacgggatt tttcctgcaa ctgaagcctc 1363441 atcgccttta agtgctaata cttcaccatt atccatgata aagcagtttt cctctgggat 1363501 gccacaatct gttgcaagtt tgacatgcat cttttgcatt ctgtactcac cgtgaatcgg 1363561 catgaagaat ttaggcttga ttaaacgaag catcagcttc tgttcttcct gtccgccgtg 1363621 accggatgta tggatatcgt taagagggcc gtgaataacc tcagcacccg cacgatacag 1363681 ctggttgatt gttcgactca cgctgattgt gttgcctggg ataggggatg aagaaaatac 1363741 gactgtatcc ccaggattga ttgaaatttg gcggtgtgtg ccgtttgcaa ttcttgataa 1363801 cgccgccatt ggttcccctt ggcttcctgt acataaaatt gttactttat tagcaggcat 1363861 acgattgatt tcgttatgct caataaacgt atttttagga cagttaatat aaccgagtgt 1363921 ctgtccaatt tcgatagccg attccatact gcgtccaaat acggcaactt ttcttccatt 1363981 ttgtacagca gcttcaatta cctgctgcaa gcggtgaata ttcgacgcaa atgtggcgaa 1364041 gataattcgg ccgtccacct tgcggaaaat gtcatgaatg ctttctccta cacggcgctc 1364101 agacatggta aactccggat tttcactgtt tgtgctgtct gaaagaaggc acaaaacgcc 1364161 ttctttaccg atttcggcca ttttcgttaa gtttgccggc tcgccgactg gagtaaagtc 1364221 gaatttgaaa tccccagtat gtacgatgtt tccgggcggc gtttttacaa caatgccgta 1364281 ggaatccgga atactgtgtg ttgttctgaa gaatgacaca gccgttttgc ggaactttac 1364341 aatatcatcc tcgccgataa tgttcagttt cgtctgtctc aataatccat gctcttcaag 1364401 tttattccga agtaagccga tcgcgagttt tccgccgtat acaggaatat tcacttgtct 1364461 gagcaggtat ggaataccgc cgatgtggtc ttcgtgcccg tgggtgataa aaagcccttt 1364521 aattttatct tcgtttttga ctaaatacgt ataatcaggg atgacgtagt caattccgag 1364581 cagttcgtcc tcgggaaact tgatccccgc atcaatcagt acaatttcat cctggaattg 1364641 caccgcgtac gtatttttac cgatttcgcc caaacctccg agggcgaaaa cagcagtctg 1364701 atcatttttt acaaatttca taccgctcat aactccaata ctttaaaatt ttcgctctgt 1364761 tgttcatatt ctaagaatgc accatcaaca ggtgtaataa actcaatatt aaatttcttt 1364821 tctttcagct ttgttctgac gtcacgctca gatacgcctt caatataaag tgaatctgtc 1364881 ttttcccgaa caggtacttc gtcagccttc tcttgataaa ataccttata aatcattcca 1364941 aatctctcct taaatgccgt atgttagact cgctcattct attatattcg aaaacggaat 1365001 ataaggaaag ccttgagcaa aataaggatc tctcaaaaag tgaaagatcc cttgtcaggc 1365061 aattgctttc ttacggagca ttccgttcca ttgtcttctg agtttctttc ttaatttacg 1365121 cagcattagc cagtccctcc tttaatgaaa aatttgtccc agagttcttt tatacaaata 1365181 gtatacggag attgaggaag acttttcgtg gttattaatg gaatttaata tgatttttga 1365241 acgaaattgt ttgctgaatg acaatctttt tgtatgatga gggtgggaat tgcagaccaa 1365301 gacgataaag gggaagttgc gatggattct aaattaatct tttttgatat tgacggcaca 1365361 atatatgatc atgataagaa tataccggaa agtacgagaa aaaccgtggc ggagcttcag 1365421 cgccaagggc atcatgtgtt tattgccagc ggccggtctc catttttggt taagccgatt 1365481 ttggaggagc tgggcatcca ctcatttatt tcctacaatg gacagtttgt tgtctttgaa 1365541 aatcaagtga tttataaaaa tccgctgcct gaaaatgcaa tcaggcgatt attaaagcag 1365601 gcggatgaag gcaagcatcc tgttgtgttt atggctgagg acacgatgaa agcgactgtt 1365661 gcggatcacc cccatgttct cgagggaatc ggcagcctta aaacagatta tccagagacc 1365721 gatgaccttt tttatgaagg aaaagaaatt tttcagcttc ttttattttg tcaggatgaa 1365781 gaagaaaaag cttatgccgc ttttcctgag tttgatctag ttcgctggca tgagctatcg 1365841 actgatgttc tgccgcacgg aggttcgaag gcagaaggaa tcaaaaaagt gattgagcgt 1365901 cttccgtttg atatcggcga tacatatgct ttcggcgacg gattaaatga tttgcaaatg 1365961 attgaatacg ttgggacagg cgttgctatg ggaaatgctg ttcccgaact gaaagaaatc 1366021 gcggactttg taacaaaacc ggtggacgag gatggaattg catacgctgt caaagaattg 1366081 ggccttttaa aataaagaaa cggctggcat tgtgccagcc gttttctctt ttagcgctca 1366141 attgcgattg cattttcagg ttctttgaaa ggattttcct tatcaatatg atcatagaac 1366201 ataacgccgt tcaaatgatc gatctcatgc tgaaacacaa tagccggaaa tccttttaaa 1366261 cgaatatcaa tattttcgcc ttctagtgtt gttcctttta ctctgatgcg agcatagcgg 1366321 ggaacataac cgggaatcgc ttcatccaca gagaggcagc cctcgccgct tgttaagtag 1366381 cttttttcaa ctgaatggct gacgatctta ggattaaaca gagcatagct gtataattta 1366441 ccggaagcat cttccgcatg aacggcgatc attcgttttt tgatattaat ttgaggagct 1366501 gcgagtccta cgccagggcg cagcttgtat ttttcggcta attctggatt ttggctgttt 1366561 ttaacaaatt cgatcatgtc ggccagctgc tgtttttctg catcagttgg aggcagctca 1366621 acaggttcgg cagtctctct gagggctgga tggccgtcac gtacgatgtt ttccatagta 1366681 atcaagaaac ttcactccta aagcttaata tgtaaattat atcggatttc ttcacaaagg 1366741 tgcaacgaaa cgaatgacca gccgtatatg gctggtcaat ttcatgctgt gtggttagca 1366801 acagcctcca cctaaataag cagctccgac aatgattaac agaatgaata aaacaacgat 1366861 tagcgcaaag gtgcggccgt agccatatcc gcagccacca tatccgtaac caccataact 1366921 gcagcagcct ccgccgtaac catatccata catattacat aacctcctct tttaattacg 1366981 ccagagcctt tataagtagg catagcgtct aatataacct atgtaaaaac aaaaaagttg 1367041 tatggtcatc tgtcctgatt tttcactttt ttgatttaat ttcagtattg catttataca 1367101 gcacggctat tgccaaatgt ccccatggat tctatagtag aaattgtcaa gattggggga 1367161 tttaacgtga aagacgctat aaaacggcgg cctggaatca agatcggagc tttttgtgcc 1367221 atggcactga tattaacagg atgcatggga caggacccgg ttgattcact tcatcattca 1367281 ttagaaaaag ccgcggaatc ggaaaagccg tttcaagaag aacaaaacac actcaaagaa 1367341 ttagaggcca aagaaaatca gctttacgat agtgttatga agctcaatat ggatgattat 1367401 aaaaaaattg ttgctttatc taataaggcg cttgaaaatg tcagcaagcg cgaagaacac 1367461 ctaaagcttg aaaatgacag catgaaaaaa tcggaaacag aatttgagga agcaaaaacg 1367521 tcagcggaac atattaagga aaaagacata aaagaaaagg ccgatgccgc agcaaaccat 1367581 atggagaaaa gatatacatc atatggcact atgtataaag agtataaaaa agcgcttgag 1367641 cttaataaaa aactgtatat gcagctgaaa gacaaagatt tgacaagaga tgatctggat 1367701 cagcagatcg ataaagtcaa tgcttcttat gaaaagatcc ttaaatatag cggagaattt 1367761 aatgaacaaa ccgaaaaata taataaagcc cgggaagatt tatatgatgc tgcaggctat 1367821 cgtgtgaaaa agagctgact cgatcagctc tttttttgaa tgaaatgcga ttcggatttc 1367881 gttcaaaatt ttcatttcta ttgtagtaca gcatagtaag gtatactagt acagttttgg 1367941 gtgcggttgg catctgtttt tttgatgaaa atgtaaagcg aatacattta ttgaaaatca 1368001 gcgatgaaaa cgattgacgg ttcttcttta tttggtgtaa actaatccat gttaagcggt 1368061 gttgtattag ttttttacaa cttcgaaata atacagttca aagcagagtg taactatcct 1368121 acataaaagg ttttggcaaa ctggggatcg gctaaaatat aatacgactt actgctgata 1368181 ctttagggta ccctaagttt gtatgtataa aaggaatgca cgtctaatga ctgtttaaaa 1368241 gaaaggaaga ggtgacttag tatggctgca aaaacgaaaa aagctatcgt tgacagtaag 1368301 aagcaatttg atgccattaa aaagcagttc gaaacgttcc aaattttaaa tgaaaaggga 1368361 gaagtcgtga atgaagcggc gatgcctgat ttaactgatg atcaattaaa agagctaatg 1368421 cgccgcatgg tatttacgcg tgtgcttgac caacgctcta tctcattaaa ccgtcaagga 1368481 cgtctcggat tttacgctcc tactgcgggt caagaagctt ctcagattgc aacgcatttc 1368541 gcgcttgaaa aagaagactt tgttcttcct ggataccgtg atgtgcctca gttaatttgg 1368601 cacggccttc cattatatca agcgtttctt ttctctcgcg gacatttcag aggaaaccaa 1368661 atgcctgatg atgtgaatgc cctttctcca caaatcatta tcggtgctca atacattcaa 1368721 actgccggtg ttgcgctagg tcttaaaaaa cgcggtaaga aagctgtcgc aatcacttac 1368781 actggtgacg gcggagcttc tcaaggggac ttctacgaag gaattaactt tgccggagct 1368841 tataaagcac ctgcaatctt cgtggtgcaa aacaaccgtt acgcgatttc aactcctgtt 1368901 gaaaaacaat ctgcagctga aacaattgca caaaaagctg tagctgccgg tattgtcggc 1368961 gtacaagtag acggaatgga tccgcttgct gtatacgcag caactgctga agcacgcgag 1369021 cgcgcaatca acggcgaagg tccaacacta attgaaacac ttacattccg ttatggcccg 1369081 cacacaatgg ctggtgacga tcctactaaa tatcgtacaa aagaaatcga aaatgagtgg 1369141 gaacaaaaag atccgcttgt acgtttccgt gcgttccttg aaaacaaagg cttatggtct 1369201 gaagaagaag aagcaaaagt gattgaggat gcgaaagaag aaattaagca agcgatcaaa 1369261 aaagctgatg ctgaaccgaa gcaaaaagta actgatttaa tgaaaatcat gtacgaaaaa 1369321 atgcctcaca accttgagga gcaatttgaa atttatacac agaaggagtc gaagtaagcc 1369381 atggcgcaaa tgacaatgat tcaagcaatc acggatgcgt tacgcacaga actgaaaaat 1369441 gacgaaaatg tcttagtttt cggagaagac gttggtgtaa acggcggcgt attccgtgcg 1369501 acagaaggat tgcaaaaaga attcggtgaa gaccgtgtgt ttgacacgcc acttgctgaa 1369561 tctggtatcg gcggtcttgc ccttggttta ggcttaaacg gcttccgtcc ggtaatggaa 1369621 atccaattct tcggatttgt ttatgaagta atggattcag tttctggcca aatggctcgt 1369681 atgcgctacc gttctggcgg acgctggact tcacctgtaa caattcgttc tccattcggc 1369741 ggcggtgttc atactcctga acttcacgct gacagcttgg aaggtcttgt tgcacaacag 1369801 cctggtatca aagttgttat tccatcaact ccttacgatg ccaaaggact tttaatttct 1369861 gcgatcagag acaatgatcc tgttgtcttc ttagagcata tgaagcttta ccgttctttc 1369921 cgtcaggaag ttcctgaaga agaatacaca attgagcttg gaaaagctga cgtgaaacgt 1369981 gaaggtactg atctttcaat catcacttac ggcgcaatgg ttcatgaatc attaaaagct 1370041 gctgatgagc ttgaaaaaga cggcatttct gctgaagttg tcgaccttcg tacagtaagc 1370101 ccacttgata tcgatacaat tatcgcctct gtagaaaaaa caggacgcgc gattgtcgtt 1370161 caagaggcac aaaaacaagc cggtattgct gcaaacgtag tagcagaaat taatgaccgt 1370221 gcgatcctga gcttggaagc acctgtactt cgcgttgcag cgccagatac agtatttcct 1370281 ttctctcaag cggagagcgt atggcttcca aaccataaag acgttcttga aacagcaaga 1370341 aaagtgcttg aattttaatc aaactgcata atcgagaggg aagatgaacg ttttccctct 1370401 attatatatc tgttttcaat gcttacgatg taaactttaa aattgcttaa tcaaactagg 1370461 aggtcgagaa ctgtggcatt tgaatttaaa cttccagata tcggggaagg tatccacgaa 1370521 ggcgaaatcg taaaatggtt tgtcaagcct aacgacgagg tagacgaaga tgatgtactg 1370581 gctgaagtcc aaaatgataa agcagtagta gaaattcctt cacctgttaa aggaaaagta 1370641 ttagaattaa aagttgaaga gggaacggtt gcaactgttg gacaaacgat tattacgttt 1370701 gatgcacctg gttacgaaga tcttcaattt aaaggcagcg acgagtctga cgatgcgaaa 1370761 actgaagcac aagttcagtc aactgcagaa gctggacaag acgttgcgaa agaagagcaa 1370821 gctcaagagc ctgcaaaagc tactggcgca ggacagcagg atcaagctga agttgacccg 1370881 aacaaacgcg tgatcgctat gccttccgta cgtaaatatg cacgtgaaaa aggtgtagac 1370941 atccgtaagg ttactggttc aggcaacaac ggacgtgttg taaaagaaga tatcgacagc 1371001 tttgtaaacg gaggagcgca agaagctgca ccgcaagaaa cagctgcacc acaagaaaca 1371061 gctgctaaac cggctgctgc accagctcca gagggcgaat tcccagaaac acgcgaaaaa 1371121 atgagcggta tccgtaaagc aattgcaaaa gcgatggtta actctaaaca cactgctcct 1371181 cacgtaacgt taatggacga agtggacgta acaaaccttg ttgcacatcg taaacagttc 1371241 aaacaggttg ctgctgatca aggaatcaag ctgacttact tgccttacgt tgtaaaagct 1371301 cttacatctg cactgaaaaa attccctgtt ttaaacacgt caattgacga taaaacagat 1371361 gaagtcatcc aaaaacatta cttcaacatc ggtatcgctg ctgacactga aaaaggcttg 1371421 cttgtaccgg ttgtgaaaaa tgcagatcgt aaatctgtct ttgaaatttc tgatgaaatc 1371481 aatggccttg caacaaaagc tcgtgaaggc aagcttgctc cagctgaaat gaaaggcgca 1371541 tcttgcacaa ttacaaacat cggttctgcc ggcggacaat ggttcactcc ggttatcaac 1371601 catccagaag ttgcgattct tggtatcgga cgcattgcag aaaaagcgat tgttcgtgat 1371661 ggcgaaatcg tagcagctcc agtcttagct ctttctctca gcttcgacca ccgtatgatc 1371721 gacggagcaa ctgcgcaaaa tgcattaaat cacatcaagc gtttactgaa cgatccacaa 1371781 ttaattttaa tggaggcgta atgttatggt agtaggagat ttccctattg aaacagatac 1371841 tcttgtaatt ggtgcgggac ctggcggcta tgtagctgcc atccgcgctg cacagcttgg 1371901 acaaaaagta acagtcgttg aaaaagcaac tcttggaggc gtttgtctga acgttggatg 1371961 tatcccttca aaagcgctga tcaatgcagg tcaccgttat gagaatgcaa aacattctga 1372021 tgacatggga atcactgctg agaatgtaac agttgatttc acaaaagttc aagaatggaa 1372081 agcttctgtt gtcaacaagc ttactggcgg tgtagcaggt cttcttaaag gcaacaaagt 1372141 agatgttgta aaaggtgaag cttactttgt agacagcaat tcagttcgtg ttatggatga 1372201 gaactctgct caaacataca cgtttaaaaa cgcaatcatt gctactggtt ctcgtcctat 1372261 cgaattgcca aacttcaaat atagtgagcg tgtcctgaat tcaactggcg ctttggctct 1372321 taaagaaatt cctaaaaagc tcgttgttat cggcggcgga tacatcggaa ctgaacttgg 1372381 aactgcgtat gctaacttcg gtactgaact tgttattctt gaaggcggag atgaaattct 1372441 tcctggcttc gaaaaacaaa tgagttctct cgttacacgc agactgaaga aaaaaggcaa 1372501 cgttgaaatc catacaaacg cgatggctaa aggcgttgaa gaaagaccag acggcgtaac 1372561 agttactttc gaagtaaaag gcgaagaaaa aactgttgat gctgattacg tattgattac 1372621 agtaggacgc cgtccaaaca ctgatgagct tggtcttgag caagtcggta tcgaaatgac 1372681 ggaccgcggt atcgtgaaaa ctgacaaaca gtgccgcaca aacgtaccta acatttatgc 1372741 aatcggtgat atcatcgaag gaccgccgct tgctcataaa gcatcttacg aaggtaaaat 1372801 cgctgcagaa gctatcgctg gagagcctgc agaaatcgat taccttggta ttcctgcggt 1372861 tgttttctct gagcctgaac ttgcatcagt tggttacact gaagcacagg cgaaagaaga 1372921 aggtcttgac attgttgctg ctaaattccc atttgcagca aacggccgcg cgctttctct 1372981 taacgaaaca gacggcttca tgaagctgat cactcgtaaa gaggacggtc ttgtgatcgg 1373041 tgcgcaaatc gccggagcaa gtgcttctga tatgatttct gaattaagct tagcgattga 1373101 aggcggcatg actgctgaag atatcgcaat gacaattcac gctcacccaa cattgggcga 1373161 aatcacaatg gaagctgctg aagtggcaat cggaagtccg attcacatcg taaaataatt 1373221 ttcatatcaa aaacagcccc gctttgagcg agggctgttt ttttattttg acagcacatg 1373281 ctgtaatggt ttaatgatgt cttctttctt tttcacacat ccctcgattt tcaccacgac 1373341 atggcgctga tcaacaacca taagggtagg gacagtttca atctcatctt cccagccttc 1373401 ttttttatca tagaccttca ttttatctat ttgctcggga taatcttttt ctaaatcaag 1373461 cagtgcatcg taataaggcg cttcctggtc tatttggttc tcatcagaaa aaaacaggat 1373521 ttgtgtatga tgaatgttgt caatccggct ttttttcatc ggattgatgg tggaaagcgt 1373581 acagcccgat aaagcaaata ctattatcag catggggaat accgcgcgat atcgcatcta 1373641 tcttctcctc tgtataaaca gtagttaact agctttagtt tatcacgaga gacggcttaa 1373701 tctgcttctt gttacctaat tgttatataa ttgaaaccgt ttttaaagtg agattacata 1373761 ttatatcaat cgtttaaaat agcaacctgg ggtatattga attttttgct gcattcttgg 1373821 atgaaagttc aagaaaacgt gcaattacat tatgtgctgt ggcatatata tcgagtaaag 1373881 cttctgtatg aagaagatat tgtatgatgg aaaatggaaa aacaaggtga atatgatgat 1373941 atgaaataaa atgtgttata cagtttgttg ttgacatttt aaatgtgaca tattaatata 1374001 ataacaacaa aagaaattaa gcgttttcaa atttcaaaga aatggggaat aagagatggg 1374061 tacgattgtt tgccaagatt gcaacgaagc cattcattac tttgaagatg agaaagtgac 1374121 aacattatat ggaacttgct gcggacaatg tcaatgtcct gttgatgaag agtaaaaaaa 1374181 agcatgcggc ttaaagccgc atgcttttta ttttttattg aattgctttt tgttctttga 1374241 tgacccggat catatgtaaa gtcgagtcct caggtccttg aacagggagg cctgcgtcaa 1374301 ggtttttaaa aatgtagctg atgttttctt ctgtaataat ttctcctggg atgaagattg 1374361 gaataccagg cggatatacc atgacaaatt cagcaataat ccgtccggat gcttctttta 1374421 atgggatgac ttccgtattt gcatagaaag catcacgcgg agtcattgcc aataaaggta 1374481 tttctggaag cagaacctca gtttgctgat gtgttacatc ttgttctgac atttgctgtg 1374541 cgatctcagt taaagcctct acaagccggt ctgcatcatt ttggctgtca ccaggagtga 1374601 aaatacacaa aatattgtac agatcagaaa gctccacctc aatattaaag gattcacgaa 1374661 gccatttttc cacgtcatgt cctgtcaggc caagactttt cacagagata atcaattttg 1374721 tcggatcata gctgtaagct gctttcgacc caagaatctc agaaccgaca caataaatgc 1374781 cttcaatctg attgaggcga tctctcgtct gattggcaag cttgagtgtt tcctcagcaa 1374841 gctggcggcc ttctgttgca aggcgttttc tggcaacatc caaagaagcg agaagcaagt 1374901 aagaagttga cgtagttgtc agcatgctca ggatggattg cactctgtct ttagatacaa 1374961 ggccttctct catgtttaaa atagagcttt gtgtcagtga tccgcccagc ttgtgtacac 1375021 ttgtcgctgc tatgtccgct cctgcctgca tagccgatag cggcaattcg tcgtgaaaat 1375081 gaatgtgaac gccgtgtgct tcatccacaa gcactggcac atcaaacgaa tgagcgagtt 1375141 ctacgatgct ttttaagtcg gctgcaacac cgaaatatgt cgggttgatg acgagaagcc 1375201 cttttgcatc cggatgctcg gtaagcgccc gtttagcaga ttcaagtgta attccgtggg 1375261 agatgcccaa ttcattgtca atttcaggat gaataaaaat tggaaccgct ccggaaaata 1375321 caatagctgt cataattgat ttatgaacat ttcttggaat aataatttta tcaccaggtc 1375381 cgcaaacagc cattaccatt gtcataatgg cgccgcttgt tccttgaaca gaaaaaaatg 1375441 tatgatccgc tccaaatgct tcagcagcca gatcttgtgc ttgtttaata atgccttttg 1375501 gcgcgtgcag atcgtctaat ggttcaatat taatcaaatc tatgcttaac gcgttttcac 1375561 cgataaattg tctgaattct gggtccattc ctgccccttt tttatggccg ggaatgtgga 1375621 attgaacagg ctgtctgctt gcatgctttt tcagtcctgt gtataagggt gtttcatgtt 1375681 gcgacaattg ttttcccacc tttgtaatca tacctatgca taatagtgtg tattaaaatc 1375741 agtttctcaa ccgtttttta gacgtaaaac aaatgaatta tattatgaac ttgaaagaat 1375801 gtaaagctag acaaaattga tagtattgtc ctgtgtttgt ttttgttgaa taatatcaag 1375861 atgagtcaag tgtcatgtgg tggttcattc aagagttatg ttttttacat atcaagggga 1375921 agatgagata tttttgtttc atcttgaaac tttttgaaaa gtccgctgtc taaccgaatg 1375981 aggccttaat aagaagtaaa ggattgttgt tcgtgttgga gttattcagt cattatgtat 1376041 tgcatttcga acgttatttt atattaagca gacaaagcac cctgctgatt caatggtcaa 1376101 ttgttgttct ggcgggctta tatcttttgg tgcatcatcc caaaataaac cggcagcgca 1376161 caatgttctt ggcgggtgtt atattgcgga ttgtgctgct ggcgggagtg tctgttgaac 1376221 ttattcacca ggtgcaatca acaaacttca ccagcgctta cttaagagag gacggaaaag 1376281 aactgctgcc gctgctgcat tttttgttat acggatatgt gctgctgacg gcttttcact 1376341 atatgctgat gccgcgtgat catggcggaa agggtaagtt ttatacgttc gaccttgctg 1376401 ttgtcagttt gccgatcgta caaatgattt ttagtttctt ttcgtattgg aaggaatacc 1376461 cggatgggat ggagccgatt gcattcgtgt ttctgttttt catcatcact cttcccattg 1376521 cgttgaatgt agtgtttttc aagctgtatt ggagaacgga taagatctta ctaggcttat 1376581 tttatacgct gattatcgga ctgcttgtct tgctgcttgc gccatatccc aatcaaatct 1376641 caaaagatta tggtgcagta atgccatata cgatttattt ggcaatggcg ggatttttga 1376701 tgagctatca tctgttccaa aagtcaggaa aggtttatgt gcgtgtgaat aagtgggtga 1376761 cgatggctgt catggtgttt tttgtcctgc tgttaaatcc gatatataac ataggaacgg 1376821 ctgctttcgc tgtatcaaag ccagcaaatg tccatgattc attcaatttt gtcggggagc 1376881 acatttcatc agaaaaagcg gaacagatac taaagtcatt ttttcctacg gatgaaacac 1376941 tttatttgca cgatacaaac atggatgtgc attatttcta ctcatttgaa agcaaaggtt 1377001 acaaagctga ggtagatgaa gtatcgcagc taattcgtaa ttatgaatac ttacaaaaag 1377061 cacatgggaa aaagctaacg aatcaggagt acaagcgaaa gtccatcgct ttccttgagc 1377121 gacacggacg tgtgttacat aaggatcata tcgaaacaaa ggtatctcaa gaagacggcc 1377181 agacagtcgt acgtatttac ctgaaaaatc aacttcataa aaaagatcat gctgatgatg 1377241 gcgcggtatt ttattgggaa aaggaaacct taatggggtt tagtgaagat ccttcgattt 1377301 atcagcttga ctctcttctg catgttcata taacggaaca agacattcac gacaaagtgg 1377361 aacaaatgtt tacagcgctg aacatatcaa aacagcctta tcagatcact gatattgaaa 1377421 gcgacagcct gcttggaagc atggtgagag ttgaaacaaa agttggaatt gttttggaat 1377481 ttgagggcga atcaggttgt ttacatagtc tttcgcttcc gatgaaaaag aatatctcaa 1377541 tggctaacag ccggctgcag catcagatat tatcgatctt cgatgctcgt ggatcagaaa 1377601 agaagaaaaa aagcagtcag ggtgacatgg tgatgtatac tgattcttct aaaacatatg 1377661 agtttgttga agctcaaggt cagctaaacg tttatgtata cagcgataca cctgatcagt 1377721 cattccccta tacgtatcgt aatggaacat tggcttacga aaaagtagct tctctatatc 1377781 aggatgtcat ttacaaaaag cgtatgcgtc cgattatcgt tcaaagaggg gatgaacggc 1377841 attatgcatg gctgatcatt attcagccgt ttggttcaaa tcgccatgat gcctatgtag 1377901 tggatggaga aacacaagag gtgaaaagtc tttatgaatc ataaagaaaa agagtctgtt 1377961 tttgtagact tatacgacct gtataaagaa ggagagctag aggatgaatc aatggaatgg 1378021 atgaaacagc atgaatccct atttcaaaag aatgcggaag acttaaagag taaaacttgt 1378081 ttaaagagaa gtcccggtgc tgaagaagaa agccaaatca gatatatgaa agtatacctg 1378141 tcttccatgt atatctgttt cattttattg gccatttgga tgacggtgtg gttttatttt 1378201 taatgaagca tagggattcc attgaggact tgtatcggca gtattatcaa gaaattttaa 1378261 attatttatt cagaaggact catcatcttg aaacagccaa ggacttagcg caggacacgt 1378321 ttgtaaaagc tcttaacggt ctggcttcgt ttagggggca ttcttccatc agaacatggc 1378381 tctacaccat tgcgcatcat acctttatca attggtaccg aagggatgtc aaataccaat 1378441 ttactgaaat cagcaaaaat gaagggttaa cgcaaacaac ttatgaccag cctgaacagt 1378501 atctgtcacg gacggtgaaa agcgaaacac tgcggcagga gctcctgaag ttaaaagatc 1378561 agcatcaatc cgttttgatt ttaagagaat tccaagagct ttcttatgaa gaaatcgctg 1378621 agatattagg atggagtctt tctaaggtga ataccacatt gcaccgggct agattagagc 1378681 taaagaaaaa catgacgaaa agtagagagg aggagcggat atgacctgct ttctagtaag 1378741 agacctgctt cctctgtatc ttgaaggtga ttgtaaaaga gaaacggaac acgttataga 1378801 agagcattta aaaatgtgca gcagctgcag agacatgtat gacacgatgg ctgagccatt 1378861 tgaattggaa agcgaacagg ccgttgagga ggcttatctg ccggaagaag aactgcgttt 1378921 taaacagagg tactatggat tactgatcat gaaagctgcc tgctggtttg gagcggcggt 1378981 tgccatgatg ctgatcatca aactgctgat ataaaaaaag cgcttgtccg attccggcaa 1379041 gcgctttttt acattaagcc tggggatgaa tcatatcgta aatagcggca agctgttctt 1379101 gtgacagggc actgaagagt ttttcataaa cgtcagcttg cagtggcgtt gcacctgctt 1379161 gtagcgctgc gtctttatca tagctgtaca catcatcttg tagcacaatg gctgcttgaa 1379221 gaatgtgaat cttgagagaa acagcggaga aaaattgttc aagtgcaagt gcttcttttt 1379281 ctgtgaagcc aagttcaact gctttttctg tatcaaattt gtaatttcca tcctcgagat 1379341 acacacattg tgaaacaatg ctgaaaaatt ctgatgtcga ttcccagagt gtagcaatta 1379401 cctgagcctc ttcttttgtc attcctaact cgacagcttt ttcgctgtca aaataatata 1379461 caccgtcttg ttcgtatata cattgattta atatatcaat gaatgtattg agatcttcgt 1379521 tagtgctcgc ctgatgctgg agttgaacag cagtgttatc aaccggtgtt tttgcgctgg 1379581 ctgcatcagg accgaacgtt aatagagcag ctgaggtcat tgcggcagtc gttaacatag 1379641 ctttttttac aaatgttttc ttcatgtttc ttctctccct tttatgaatt gtgctacaaa 1379701 ttccattata gggagtagtt tccggtggag gaataggcgc tatggtattt tatgtgtatc 1379761 gttgccgaac tactttttga aggctgcacg tgtgatcgtt agaacgattg tctatgtatg 1379821 aaggctgttt tgcatcttcc tgactaagaa acaggggaga taaggcttaa agaaatgaaa 1379881 aacaccgctt tctttgcggt gttttttgat tacaatgtcg ccggcggggc aatgctttta 1379941 atcaagcaag ccttgttcgc gcattttctt ttttaatgta aatccgccgc ccatgacagc 1380001 gcaaacaagt acaatgctgg cgataatgcc tgcagggctt ttttcagcga taaagacgcc 1380061 gatcagcata atgctgaaaa ccgctgcaaa tgcaaataat agtaaaagcc aattcatttt 1380121 tttcataaat tccatcccct tttacgtctt atattaagtt tacagaaaaa cgtgacgctt 1380181 ttaaagagga tgtgtgatat aatatgaaag ttatctaatt tttttaggag atgaaaaagt 1380241 gaaacttcga aatgatcttc gcaacatcgc gattattgcc cacgttgacc atgggaaaac 1380301 gactctagtc gatcagcttt tacatcaggc tggtacgttc cgtgccaacg aacaggttgc 1380361 tgaacgcgca atggactcta atgatcttga acgcgaacgc ggcattacaa tattggcgaa 1380421 aaatactgcg attaactata aagatacacg tatcaatatt ttggacaccc ctggacatgc 1380481 agactttggg ggagaagtag aacggattat gaaaatggtt gacggcgtag tgcttgtcgt 1380541 tgacgcatat gaaggctgta tgcctcaaac tcgttttgtt ctgaaaaaag ctcttgagca 1380601 aaacctgaac cctgttgttg ttgtaaacaa aattgaccgt gactttgctc gtccagagga 1380661 agttatcgat gaagttctgg atctgttcat tgagcttgat gccaatgaag agcagctcga 1380721 gttcccagtg gtatatgctt ccgcgattaa tggaacagcg agtcttgatc cgaaacaaca 1380781 ggatgaaaac atggaagctt tatatgaaac cattattaag catgttccgg cacctgttga 1380841 taatgcagag gagccgcttc aattccaagt tgcccttctt gactacaacg actatgtagg 1380901 ccgtatcgga atcggacgcg tattccgcgg cacaatgaaa gtcggacagc aggtttctct 1380961 tatgaagctt gacggaacgg caaagtcatt ccgtgttaca aagatttttg gtttccaagg 1381021 cttaaagcgt gtggaaattg aagaagcaaa agcgggagac ctcgttgcgg tttccgggat 1381081 ggaagatatc aacgttggtg aaacggtatg tcctgtagac catcaagatc cgcttccggt 1381141 ccttcgcatt gatgagccga cacttcaaat gacatttgtc gtgaataaca gtccgtttgc 1381201 aggccgtgaa ggcaaatatg taacggcccg caaaatcgaa gagcgtcttc aatcacagct 1381261 tcagacggat gtgagcttgc gtgttgagcc aacagcttct cctgatgctt gggttgtttc 1381321 aggacgcggt gagctgcact tgtcaatttt aattgaaaat atgcgtcgtg agggctatga 1381381 gcttcaagtg tcaaaacctg aagttattat caaagaaatc gacggcgtac gctgtgagcc 1381441 tgttgaacgt gtgcaaattg atgttcctga agagcatact ggctctgtaa tggaatcaat 1381501 gggtgcccgc aaaggcgaaa tggttgatat gatcaacaac ggaaacggcc aagtccgtct 1381561 catctttaca gttccttccc gcggattgat cggttactct acagaattcc tatcattaac 1381621 acgcggattc ggtattttga accatacgtt tgacagctac cagccgatgc aggcaggcca 1381681 agtcggcgga cgccgtcaag gtgtacttgt gtcaatggaa aacggaaaag caacatcata 1381741 cggtattcaa ggaattgaag accgcggtgt catcttcgtt gagccgggta ctgaagtata 1381801 cgaaggaatg atcgttggag agcataaccg tgacaacgac cttgttgtta acgtcagcaa 1381861 aatgaaacag caaacaaacg tccgttctgc gacaaaggat cagacaacta caattaaaaa 1381921 agcgcgcatc atgtctcttg aggagtctct agagtactta aacgaagatg aatattgtga 1381981 agtaacacct gaatccatcc gtttaagaaa gaagatcctc aataagaacg aacgtgaaaa 1382041 agcagctaaa aagaaaaaaa cagcaggatt gtcttaatct cgtgcagaat ttgaaaagat 1382101 agaacccgta cgtttacagg ggagggaatc tttttgaatg acgtaagcga acgcctgtcg 1382161 ttcttcgccg ctctatatca agtagaccgg cagcctgcgg caggcatgtg gctgctgtac 1382221 ggcacgattt ttgtgttggc cgttattgta tttaagcttg gatttgctaa acggcttcct 1382281 gtattaaaat ctgcagtggt gtatgtattt ttggctttgg gctgcactgt tttgactttt 1382341 ttaggggtgt ttttgcccgt ggcagaagga ttggtcgtcg ctgcgctgat tttaatcatt 1382401 tacaaaatcc ggctgtatca gtcgaaaaaa ggacagtctg caaaatcata aaagactcag 1382461 ctgaaagctg agtctttttt gtgttctgta tggttaagcg gccgctttat tttttgactt 1382521 tttctttttt ctgctgtccc gggtgaaaag taaattttcc cgttttcagc cgttcctctg 1382581 tttttttggc aatccgatcg tggcattcct ggcacatata tgtatggatc gggcggtttc 1382641 gaagccgttt cgcgatcagg gtatcatcat caattgtttc aattttatcg caaatagaac 1382701 atttgaccct catcatatca cctctttcac taacatgtat tataccacgg atcagaagct 1382761 gtccaaaata agaaaaagct aaagcgcaag gctatagctt agtcattgtt gttctttttc 1382821 atatgatgat cagattgatc gttttgttcc ttctccattt cctgttgctg ttttctattt 1382881 aattggtcat tttgctgctt tgtttgcggt tcatcttcat tgtcaatcac atcgttaggc 1382941 acttcgggaa gcactcggcc gacaattgca gctaattcat ccagtatacc tgttaccgga 1383001 tggccctcgc tgatttctct gctcatttcg cgaaggcggc tgaccgtatc gggatcagca 1383061 atgactactg cgttggcgcc atatcgatca ttctttagcg cctgagctac agaatattta 1383121 atggtttcca ctttgcttct gtccaaagta tcatcgacat caatcccaac aacagcatag 1383181 cctcccagca caacggctgt tgcatccttg acgtcggggt ttttttcagc aacgctgaca 1383241 agatgcttgg caatatccgt tcttgttcca ttgtcttttg tttcttgagt tgtgtccttt 1383301 acgtgaatcg gtttagtctc ctgctgtctt gttgattctt tttcaacatt ctggccctgt 1383361 tttccttgtt gataggcaca agcggacagg ataagtgtca gctgtatgat aatgaaaaga 1383421 attcgcactt gcgggttccc tccttaaaat gctttcatta attttattgt tgaattaacc 1383481 ttctatcttt atgcacaaaa acatatattt tagcaggcat tcaccttttt catcaaaaga 1383541 gaagcaggaa gaactttgac ccttatatca ggaggctgag acttgagtaa aatttatgtg 1383601 ttagatacga atgtgttatt acaggatcct aacgcgatat tttcttttga agaaaatgag 1383661 gttgtcatcc ctgctgtcgt tttagaagag gttgattcaa aaaaacggta tatggacgaa 1383721 gttgggagga atgcaaggca cgtatctaag ctaatcgatg cgctaagaca aaagggcagg 1383781 ctgcatgagc atgtaccgct tgacaccggc ggcacactga gaattgaact gaatcatcgt 1383841 tcgtttcacc agctgcaaga gatctttatt gaaaagacga acgataatcg catattagcc 1383901 gttgcgaaaa acttaagcct cgaggaagaa accaaggaaa atggcaggcc ggttatcctt 1383961 gtcagtaagg atgtactggt cagggttaaa gccgacgcaa tcggactgct tgctgaagat 1384021 ttcttgaatg accgggttgt ggacaatgat gaaatgtaca gcggctataa agatttatat 1384081 atcagccagc agctgttcag ctctttttac gggaaaaatc aaatttcagt aaacgatgtg 1384141 aaacagcatg cgttttatcc gaatcagttt gctttaatga aggatgagct aggagggtcc 1384201 tcctcggcag tcggaattgc agacaaaacc ggaacggtat taaaaagact cgtatttgat 1384261 gatgaacata tatggggaat caggccgaaa aatgtacagc agacaatggc attagagctt 1384321 ttgctgcggg aagatattcc gcttgtcacc ctgatcggca aagcgggaac cggcaaaacg 1384381 ctcttagctt tggcggcagg gctattacag acagaagact tgggaatata taaaaagctg 1384441 gtcgtcgcaa ggccgattgt tcctgttggc aaggacatcg ggtatttgcc aggcgaaaaa 1384501 gaggaaaagc taaagccttg gatgcagccg atttttgaca acttagagtt tctgtttaat 1384561 gcgaaaaaac caggggagct tgatgctatt ttggcgggaa ttggctcaat tcaggtagag 1384621 gcgctgactt atatcagagg gagaagcatt ccagatcaat ttattatcat tgatgaagcg 1384681 caaaatttga ccaggcatga ggtgaaaacg ttgctgacga gagtcggtga gggcagtaaa 1384741 attgtcttaa tgggcgaccc tgaacaaatt gatcacccat atttagacag tctgaacaat 1384801 ggtttggcct atgtggttga gcggtttaaa ggacaaccca tctcaggcag cgtgaagctg 1384861 ttaaaaggtg agagatcagg tctcgcccag cttgcagctg atttgctgta acacttaaat 1384921 gatttcgatc tcttttacat cggtaatcgg ctgtttgtga tgaaccgggt cttcaaagta 1384981 aatatgcacg gggccgcctt cttgaatcgg cttgcctgcc tcactgaaat ggacaatact 1385041 gttcagagcg gtttccagag aaacggcggc ctttcccgaa cttgtgacaa atacacattg 1385101 tgtcgcagag ctgttcggct cagcattttt caggacagtc ccaagtctca ttgcgaaact 1385161 gccgttcatc agtttttgct tctcatattg cttttccgtc tttaatgtag gcggcgcgat 1385221 tcgcccctct ctgatgacgc gttccggatc aaggtcggat tcatccccgg ctgattgtaa 1385281 atatgtgtct tgactgtccc ctttgcggtc aaacgaaaat ttgcgatcat caaaaatcca 1385341 tacgcttgga tcaatggtaa ttggatatgt aacattgcct tttacttgga taacgctcat 1385401 gatatgaccc ccttctctca aaattataaa agttttcgca tgaattgtca ctttgtgtac 1385461 aaattatgtg tattgaaatg ctgagggaac gagggtgttt gcatggtatg ccagcataat 1385521 gatgagcttg aagccttagt gaaaaaggcg aaaaaagtaa cggacaaggg ggaggtagcc 1385581 agctatattc ccgccttggc aaaagctgat aaacacgacc tgtcagtggc gatttattat 1385641 tccaataatg tttgtctgtc agcaggtgac gtagaaaaaa catttacgct tcaaagtata 1385701 tcgaaagtcc tttcccttgc tttggtgtta atggaatacg gcaaagataa ggtcttcagt 1385761 tatgttggac aggagccgac cggtgatccg tttaattcaa ttatcaagct cgaaacagtg 1385821 aatccgagca agccgttaaa ccctatgatt aatgccgggg cattggtagt gacaagtctg 1385881 ataaggggaa gaacggtaaa agagagactt gattatttgc tttcttttat cagaaggctg 1385941 acaaacaacc aagagattac atactgccgg gaagtggctg aatctgaata cagcacttca 1386001 atgattaatc gggcgatgtg ttattatatg aagcagtacg gcatttttga agatgatgta 1386061 gaggcagtaa tggatttata tacgaagcaa tgcgcgattg agatgaacag cttggattta 1386121 gcgaaaatcg gatctgtatt cgcattgaac ggcagacatc cagagactgg ggagcaggtc 1386181 atctcaaaag atgtcgctag aatttgcaaa acgtttatgg tgacgtgcgg aatgtacaat 1386241 gcaagcgggg aattcgcaat taaggtcgga attcctgcga aaagcggcgt atccggcggg 1386301 ataatgggca tttcgcctta cgatttcggg atcggcatat tcggccccgc attagacgaa 1386361 aaagggaaca gcattgcagg tgtaaagctt ttggaaataa tgtctgagat gtacaggctg 1386421 agtatttttt aatttatgtc atatgcttaa atcctcttgc attttctgtt gatacccttt 1386481 atgataaata gaagaattag gtactcgcct ggggaacgga gggatacttt tggcttcaga 1386541 gatgatagtt gaccatcggc aaaaagcttt tgaactctta aaagtggacg ctgagaagat 1386601 tttgaagctg atccgagtac aaatggataa cttaacgatg cctcaatgtc ctctatatga 1386661 agaggtttta gatactcaaa tgttcgggct ttcgagggaa atcgattttg ctgtccgcct 1386721 gggattggtt gatgaaaaag acggtaaaga ccttttatac acattggagc gcgaattgtc 1386781 tgctttgcat gacgcgttta cagctaaata aatgataaaa ctcaaactta ttaacagttt 1386841 gggttttttt ataaccgcta tttttctctc atctcataaa agacggtctt tttttacaca 1386901 ttccttccga atcgtataga gattcttcgt ctcgtttgat aaattgtagt aaaataaaaa 1386961 agataaatac ataaaaacca tagataatgg aagttagaag cagggaagag gatgttatgt 1387021 taaaaaaaat gctaaaatct tatgattact cactgatatt cgcaatcgtt ttattatgcg 1387081 gattcggttt agtgatggta tacagctcaa gcatgattac ggctgtctcc cggtatggag 1387141 taagcagtaa ttttttcttc atgcggcagc tgtttgcttt aattgcgggt ggcgctctat 1387201 ttattctcat ggcgttgttt ccttataaag cactggccca tcaaaagttt cagaagggga 1387261 tactgcttgt atctgttctt gcgcttatct cactgtttgt tttcgggcat gttgccggaa 1387321 acgcgcagag ctggtttaaa atcggcggaa tgagtattca gccgggggag tttgtgaaac 1387381 tggtcgtgat tttatacctt gcagccgtat atgcaaaaaa acaaagttat atcgaccatc 1387441 tgttaacggg agtagcccct ccggtagtca tgacgcttat aatttgtggg ttaattgcca 1387501 tgcagccaga tttcggtaca gccatgatta tagggttaat tgcgacgtgc atgatcttgt 1387561 gctccggctt cagcggaaag acgctggtga ggcttgtgat actgggcgga attgttttca 1387621 ttttagtcag ccctattatc tatttgaatc aggacaaaat tttaactgaa ggccgtttag 1387681 cgcgttttga gagtcttgaa gacccattta agtatgcaaa ttcatcaggt ttgcaagtga 1387741 tcaattctta ttatgcgatc agctcaggcg gcattttcgg cctggggctc ggtgaaagta 1387801 tccaaaaata cggatatctg cctgaatcac acactgactt tattatggct gtcattgctg 1387861 aagagctcgg catttttggg gtattgtttg tgattttctt attgggtttt gtcgtcataa 1387921 aaggttttta tattgccaga aaatgcgagg acccgtttgg aagtcttctg gcgatcggca 1387981 tttcaagcat gattgccatc cagtcgttta ttaaccttgg cggtgtcagc ggattaattc 1388041 cgattacagg ggttacgctg ccatttatca gttacggggg ctcttctttg gtgctgctgc 1388101 tggggagtat ggggatatta gcgaatatca gcatgtttgt gaaatattca gagaataaga 1388161 aaaagaaaga gcccttggcg ccgaagggaa tgaaaaagaa acagctcaaa aaaactgttt 1388221 atctgtaaaa aacaagtgtg tacaggggaa ggatattccg ctatgataga ttatattcca 1388281 ttcgggtaag ggggagaaaa gtttgtctca gcaatcgata caaaaagtat tagtagcaaa 1388341 caggggagaa attgcaatcc gaatattccg ggcgtgtacc gagttgaata ttcgtacagt 1388401 tgcggtctat tcaaaagaag attccggttc ctaccatcgg tacaaagcgg atgaagcata 1388461 cttggtcggt gaagggaaaa aaccgattga tgcttacctg gatattgaag gtatcattga 1388521 tattgcgaaa agaaacaaag tcgatgcaat tcatccggga tacggtttct tatctgaaaa 1388581 tattcatttt gcgagacgat gtgaagaaga aggcatcgta ttcatagggc caaaatccga 1388641 gcatctcgat atgtttggtg acaaggtaaa agcgcgtgag caggcagaaa aagcgggaat 1388701 ccccgtgatt ccgggaagcg acggtcctgc cgaaacgctt gaagccgtcg aacaatttgg 1388761 acaagctaac ggttatccga tcatcattaa agcctcgctt ggcggcggcg gccgcggtat 1388821 gcggattgtc agatctgaaa gtgaagttaa agaagcatat gagcgtgcta aatcagaggc 1388881 gaaagcagcc tttggcaatg atgaagttta tgtagaaaaa ttaattgaga atccgaaaca 1388941 tattgaggtt caggtcattg gagacaagca gggcaatgtc gtccatcttt ttgagaggga 1389001 ttgctccgtt caaagacgcc atcaaaaagt cattgaagtg gcgccgagtg tctcgctgtc 1389061 acctgaatta agggaccaaa tttgtgaggc tgcagttgcg cttgccaaaa atgtaaacta 1389121 tataaatgcg gggacggtcg aattccttgt tgcaaacaac gagttctact ttattgaagt 1389181 aaatcctcgc gtacaagttg aacacacgat aacagaaatg attactggtg tcgatattgt 1389241 tcaaactcag atccttgttg cccaagggca cagccttcac agcaaaaaag taaatattcc 1389301 tgagcaaaag gacattttta caatcggcta tgccattcag tcacgggtta cgactgagga 1389361 tccgcaaaat gatttcatgc ctgatacagg aaaaatcatg gcttaccgct caggcggcgg 1389421 ttttggtgtc cgtcttgata ccggaaacag cttccagggc gccgtgatca caccatacta 1389481 tgattcactt ctcgttaagc tttcaacttg ggctttaacg tttgaacagg cagctgccaa 1389541 aatggtgcga aaccttcagg agtttagaat cagaggcata aaaacgaaca ttccgttcct 1389601 tgagaacgtt gcaaagcatg agaagttcct gacagggcaa tatgatacat ctttcattga 1389661 tacaacgcct gaattattta atttccctaa acaaaaagac cgcggaacga aaatgctcac 1389721 ttacatcggc aatgtgacag tgaacggctt ccctggaatc gggaaaaaag aaaaaccggc 1389781 gtttgacaaa ccgttaggcg taaaggtaga cgttgatcag cagcctgcca gaggaacaaa 1389841 gcaaattctc gatgaaaaag gtgcagaagg gcttgcaaat tgggttaagg agcagaaatc 1389901 tgtcctttta actgatacga cattcaggga tgcccaccaa tcgttattgg caactagaat 1389961 cagatcgcat gatttgaaaa aaatcgcaaa tccgacggct gcgttatggc ctgaactatt 1390021 cagtatggaa atgtggggag gcgcgacctt cgatgtagcc taccgattcc tgaaagaaga 1390081 tccgtggaaa cgtttggaag atcttcgcaa agaagtgccg aataccttat tccagatgtt 1390141 gcttcgctca tcaaatgcgg tcggctatac gaattatccg gacaatgtga ttaaagaatt 1390201 tgtgaagcaa tcagctcaat ccggtattga tgtgtttcgt attttcgaca gcttaaactg 1390261 ggtaaaaggg atgacgttag ccattgatgc tgttagggat accggcaaag tggcagaagc 1390321 tgcgatttgt tatacgggag atatccttga caagaaccgg acgaagtacg accttgcata 1390381 ttatacatcg atggcgaagg agcttgaggc ggccggagcc catattctcg ggattaaaga 1390441 tatggcaggg ctgttaaaac cgcaggctgc atatgagctc gtttctgcgt tgaaagaaac 1390501 gatcgacatt ccggttcacc ttcatacgca tgatacgagc ggaaacggta tttatatgta 1390561 tgcgaaagct gttgaagccg gcgttgatat catagacgtg gcggtcagct caatggcggg 1390621 attaacgtca cagcctagcg cgagcggatt ttatcatgcg atggaaggca acgaccgccg 1390681 tccggaaatg aatgtccaag gcgttgaatt gctgtcccaa tattgggagt cggtgcgtaa 1390741 atattatagt gaatttgaaa gcggaatgaa gtctccgcat actgaaattt atgaacacga 1390801 aatgccaggg ggccaataca gcaacctgca gcagcaagcc aagggagtag gccttggcga 1390861 ccgctggaac gaagtcaagg aaatgtacag acgcgtgaac gatatgttcg gtgacatcgt 1390921 caaggtaacg ccttcctcaa aagtagtcgg agatatggca ctctacatgg tgcaaaacaa 1390981 tctgactgaa aaagacgttt acgaaaaagg tgaatcttta gatttccctg attctgtcgt 1391041 ggagcttttt aaaggaaata tcggccagcc tcatggcgga ttcccagaaa aactgcaaaa 1391101 gctgatctta aaagggcagg agccgattac agtcagaccg ggcgaactgc ttgagccggt 1391161 gtcatttgaa gcgatcaaac aggaatttaa agagcagcat aacttggaaa tttcagatca 1391221 ggatgctgtg gcatatgccc tttatcctaa agtcttcact gattatgtga aaacgacaga 1391281 aagctatgga gacatctcgg tattagatac accgacattc ttctacggta tgacattagg 1391341 tgaagagata gaagttgaaa ttgagcgcgg caaaacgctg atcgttaagc tgatttcaat 1391401 cggtgagcct cagcctgatg ccacccgcgt cgtttatttc gaactcaacg ggcagccgcg 1391461 tgaagtagtc attaaagatg aaagcattaa gtcttccgtt caggaaaggc tgaaagcaga 1391521 ccggacaaat ccaagccaca tcgcagcttc catgcctgga acagttatta aggtattggc 1391581 tgaagcaggc acaaaagtca ataaaggtga tcatttgatg attaatgaag cgatgaaaat 1391641 ggaaacaacg gttcaggcgc ctttctcagg aacaatcaag caggttcatg tgaaaaatgg 1391701 tgagccgatc caaacgggag atctgctcct tgaaattgaa aaagcataaa aaacaaagag 1391761 tgtatatcaa tgatatacac tcttgttttt tatatagaaa atgtggagtg aaacagatgg 1391821 ttagaagaga tataagggga cttcagagat tatagagtac tgtcacaagc ccaaaataaa 1391881 aagaggctta tacagccaat attttagatg ctttgtagta tgccgtgcat atttctttaa 1391941 gcactatctg atttaaaagg ctttaatact tatgttcgcg agctatagat ccatatgaaa 1392001 tttctataat cacgatgaga aaggggacag accgaagtga gccgctcact gatcatcaag 1392061 ttcggcgaag gctggcgatt gaaacgcata aagcgccaaa aaacaagaca taaaaaagac 1392121 caaagccgcc taaggctttg gtcttgagtc cttatgattg cctggattca taacggaaac 1392181 gagcaatcaa taataagaag tagcatagaa cgccaaacag acaggcaata aagaacgagt 1392241 gggcaagtgc aaagcccaga gccagttcag agtatacgat cataataccg gacagtgcct 1392301 gtaatgtaat gaaaataaga catgagatcc atccccaaaa gatctgtttt tgatctttat 1392361 aggaagtaat agcatgaaca gcggcaacaa taatccatac aaataaaagt aaggctgctg 1392421 ctctgtggcc catttgcacc cattcatgga attgggtcgg aagtccattg ttcagcgggc 1392481 tgcacagcgg cacattagga catgccagac ttgattcagt gtgtcttaca tatgcgcctg 1392541 tatacacaac gatataggaa tatattaaaa ttcctatcat gtgaaattgc atctttttgc 1392601 cgatttgaag cggcttaacc agtgttctga ctgatttatc agcttcaaat atgagcaatg 1392661 ttaaaataag cactgaagca aaagaaatta atgagatgcc gaagtgaagc gccataatca 1392721 gcgcgttcga accgaatacg acagccaatg cgccaagcaa tgcctgaaga aataaaaaga 1392781 taattgacat gatcgcgaga aacgttgttt cacgaaaaat cggcgtgatt tttctccatg 1392841 accaaaacgc aaggcttagc acaaggataa tagagattcc gcttgcgaat cggtggctcc 1392901 attcaataat tgaagccgga ttcagttcag ggaaaaaacg gccgtgacac agcggccact 1392961 gtctgccgca tccttggccg gaacctgttt ttgtaacgag ggcacccccg attaaaacaa 1393021 ttagcatgac aaatgtcgtc agaacaccga gagcttttaa tgctttattc atacaatatt 1393081 caccttctta acatactgct gcaattttat atacgttcca agtgtaagcg aatatgtgtt 1393141 ttgtggcaat tcccagagcc ttttgttcac aaaaatataa tagaatgacg gcttctggaa 1393201 aatgtacact tgattattca tgccgggtct gatagaaata aggtaaacgc aatgccgatt 1393261 tggagattgc cttcatcttt ggtaaaattc ataaaaagtt cacaaataaa ttcctgtttg 1393321 tcgtttaata tttaatagga tgttttttta caagatgtta tcttgtatga tagagttgca 1393381 ggttatttta ttctcctgcg ttaggtttgt aagggaggtt tacgttatgg ctaactccag 1393441 aatcttaaat gatacagcta tagacggaca aattgaagaa acaacggcat ggaaagattt 1393501 tctgtccctt attaaaatag ggatcgtcaa ttctaacctc atcacgactt tcactggaat 1393561 gtggcttgca ctgcatatat ccggtttaag ttttttaggc aatataaaca ccgttcttct 1393621 tacgttaatc gggtcttcac tgattattgc gggctcctgc gcgatcaata actggtatga 1393681 ccgggacatt gaccatctta tggagcgtac gaaagtaaga ccgacggtta cgggtaaaat 1393741 tcagccgagt caggcgttat ggtctggaat tttgctggtt gctttaggat tgatcatgct 1393801 gctgatgaca actgtcatgg ctgctgttat cggttttatc ggagtcttta cgtatgttgt 1393861 attgtacaca atgtggacga aacgccgcta tacgattaac acagtagtag gaagcgtttc 1393921 cggtgcagtg ccgccgctta ttggatggac ggcagtggaa gggaatatcg gtgtcgtagc 1393981 atgggtgtta ttcatgattt tatttatttg gcagattcct cacttcttag cattggctat 1394041 taagaaaact gaggattaca gagctgcaaa tattccgatg cttcctgtcg tatacggatt 1394101 tgaagtgaca aaaagacaaa ttattgtgtg ggttgcgtgc ctgatgccgc ttccgttttt 1394161 ccttggtagc ctgggtcttc cgattgtcat tctcggcttg ctgttaaata tcggctggct 1394221 gattcttggc ttaatgggat tccgctccaa gaatatcatg aagtgggcaa cgcagatgtt 1394281 cgtttactcg cttaactaca tgacaatcta tttcgttgcc atggttgtct tgacgctttt 1394341 ctaaaaaata gatatgatgc ttgttttatc gcttcaaaat aaacgatgac aactagtaaa 1394401 tgccgccttg acctcttgtt taatcaggcg gctttacttt tatacataga tggcattttg 1394461 agtaaaaaaa ctcataattt aagagaagag gaaatgtaag tgctttattg gtgataggtt 1394521 ggatggcgat agatttcgat ccgctttccg cctttgtatt gaccagaaaa ggggttgggt 1394581 gaaatggtaa agcattggcg tcttatttta ttattagcct tagtgccgct tctattaagc 1394641 ggatgtggaa aacctttttt atccacgctc aagcctgctg gcgaggtggc tgataaacag 1394701 tatgacctga cagtgctcag cacattgatt atggtggttg ttgttgcagt agtatctgtt 1394761 atcttctttt atgtgattgt gagattcaga agatcacggg tcggtgagaa cacgataccg 1394821 aaacaggtag aggggaataa atttttagaa atcacatgga ccgtgatccc gattttgctg 1394881 ctcattattc ttgtgattcc tgttgtatta tatacgctgg agctagcgga cacatcacca 1394941 atggataaaa aaggccgcaa agctgaggat gctcttgtag tcaatgttag ggcaaattta 1395001 tactggtggg agtttgagta ccctgattac ggcattatca caagccagga gctgattgta 1395061 ccgacagatc agcgtgtata ttttaattta aaagcctctg atgtaaaaca ttccttctgg 1395121 attccttcag ttggaggaaa acttgatacg aatacggata atgaaaataa gttcttcctg 1395181 acatttgatt caaaacgaag caaagaggca ggagatatgt tttttgggaa gtgtgcagag 1395241 ctttgcggcc cttcacatgc gctgatggat tttaaggtga agacgatgtc tgcaaaagaa 1395301 tttcagggct ggacaaaaga aatgaagaac tataagtcta cagcagagag cgatttggct 1395361 aagcagggtg aagaactgtt taaagagaaa aactgcctga gctgccatgc ggtagagccg 1395421 aatgataagc gtgcagaagc cgctagaacg gcacctaact tggcgacctt cggtgaaagg 1395481 acaaaagtgg caggggtgaa agaggccaac aaagaaaatg tgaaggcttg gctgaaggac 1395541 cctgacagca taaagccggg gaacaaaatg acaggcacat atccaaagct ctcagacagc 1395601 gaaacaaatg cgctttatga atacttaaaa ggcttaaaag cggaaagcaa gtagggaaga 1395661 aagggagata ttgggggagg tcacatatgt tgaatgcgct tacagaaaag cggacgcgcg 1395721 gatctatgct ttgggattat ttgacgacgg tggaccataa aaaaatcgca attctttatt 1395781 tagtggcagg gggattcttc tttcttgtcg ggggaattga agcgatgttt atcagaattc 1395841 agcttgcaaa gccggaaaat gcgtttctca gtgctcaagc gtacaatgaa gtaatgacta 1395901 tgcacggaac gacgatgatc tttctggctg cgatgccgct cttatttgcc ttgatgaatg 1395961 cggttgtgcc tttgcagatc ggggctcggg acgtttcgtt tccattttta aacgcgcttg 1396021 gtttttggct cttctttttc gggggcattt tcttaaatct aagctggttt ttgggcggag 1396081 cgccagatgc gggctggaca tcatatgcct cactttcgct tcattctaaa gggcacggca 1396141 tagacttttt cgtcctcgga ctccaaatat cggggctcgg gacgctgata gccgggatta 1396201 actttttggc cacgattatc aacatgaggg ctccgggcat gacgtatatg aggctgcctt 1396261 tgtttacatg gacgacattt gtggcctcgg cattgatttt gttcgcgttt ccgccgctta 1396321 cggttggatt ggctctcatg atgctggatc ggctgttcgg aaccaatttc tttaatccgg 1396381 agcttggcgg aaatacggtc atttgggaac atttattttg gatcttcggc cacccggagg 1396441 tttatatcct aattttgcct gcattcggta ttttttctga ggtcatccct gtgttcgcca 1396501 gaaagcgttt gtttggctat tcttcaatgg tttttgcaat cgtgctcatt ggctttctgg 1396561 gctttatggt ttgggtgcac cacatgttca cgactggtct cggcccgatt gcaaatgcga 1396621 tttttgcggt tgcaacaatg gctatcgcga ttccgaccgg gattaagatt tttaactggc 1396681 tgttgacgat ttggggagga aatgtgaagt atacaaccgc tatgctgtat gctgtctcat 1396741 ttattccatc ctttgtgctc ggcggtgtga cgggagtcat gctggcagct gctgcggctg 1396801 attatcagtt tcatgatacg tattttgtgg ttgcgcactt ccactacgtc attattggcg 1396861 gcgttgtatt cggcctttta gccggtgttc atttctggtg gccgaaaatg ttcggtaaaa 1396921 ttctgcatga aacgatgggg aaaatttcat ttgtattgtt ttttatcggc tttcacctca 1396981 cgtttttcat tcagcatttt gtcggcttaa tggggatgcc gcgccgggtt tatacgtttt 1397041 tgccaggaca gggtctggaa accggcaact tgatcagtac aatcggggcg ttttttatgg 1397101 cggcagctgt tattcttctg ctggtcaatg tcatatggac atcggtaaaa ggtgaatatg 1397161 taggtgctga tccatggcat gacggacgta cgctggaatg gaccgtttct tcaccgccgc 1397221 cggagtataa ctttaaacag cttccttttg tcagaggact tgatccgctt tggatcgaga 1397281 agcaggcagg gcacaaatca atgacgccgg cggaaccggt tgatgatatt catatgccaa 1397341 acggctcaat cctgccgctc atcatttcct tcggcctttt tgtcgcagcg ttcgggctgc 1397401 tgtacagaag tgattacgct tggggcctgc cggtgatctt tatcgggctc ggcatcacat 1397461 ttattacgat gctgcttcgt tcagtaattg atgatcacgg ctatcatatt cataaagagg 1397521 aactgccgaa cgatgataaa ggggtgaagg cataatgcaa gttcaagaaa aattcaccgc 1397581 agaaaccttt ccagcttctc ctgaaaaagt aaccctggaa gggaaaaata aatttttagg 1397641 cttttggctt tttcttggcg gagagactgt tctgtttgcg tctctcttcg ccacgtttct 1397701 tgcgcttcgg aattcaaatg ccggtgatcc gcctacgacg gaaatgttcg atgtgacact 1397761 tgtattcatt gccacaatgc ttctattaac gagcagttta acgagtgtgt acgcgatgta 1397821 ccacatgaag aacttttcct tcggcaagat gcagctttgg ctgggaatta cgattttatt 1397881 gggggcgggc tttttaggac tggaaatcta tgagttcaag cattacaccc atgaatttgg 1397941 ctttaccatc acaagctctg cccttggttc tgcgttttac acgcttgtcg gtacacacgg 1398001 cgcccacgtg gcatttgggc ttatgtggat cagcacgctt atgatccgca atgccaagag 1398061 agggctgaat ctgtatacgg cgcctaagtt ttacgttgcc agcctttatt ggcactttat 1398121 tgatgtcgtg tgggtcttca tctttaccgt tgtatattta atggggatgg tgggataaac 1398181 atggtcgata aaaaaagcag agggcatatc aatagcgacc ttgaatttaa gaaaaaaaag 1398241 catgcccggg agatgaaata tcaagtcctg tcttttggtt taatgatcgg tcttacgatt 1398301 gttgcatttc tgactgtggc cacggacggt gtcggcagct ggtttacgat tcctttcatt 1398361 attttgctag ctgcaattca agtcattttt cagctgtatt atttcatgca tatgaatcag 1398421 aaagggcatg aggcgccggc actgtttttg tattcagggg tgtttgtcgc gtttatcact 1398481 gtgcttgcgt ttgtgacaat tatatggtgg taatttgaac agccgccgga ggtgaagaaa 1398541 tgaatcagtt ggagatattt gggtttcgcg cgatgtggag cccttatctt ttttgtatcc 1398601 tgttaggcat tacggcgctt tatctctatt tttacaggcg aatgtcttca aagccgaatc 1398661 gaataactgg taaagagatg gtgtgctttc tgtcggcgat gctgttttta tatgcagccg 1398721 agggaagccc ggttgatctg ctcggacata ttatgttcag tgcgcatatg gtgcagatgg 1398781 ccgtcctgta tttggttgtc ccgccgctgt taatcgcggg gattcctgca tggctctggg 1398841 aaaaaatcat tttcaggcct tcaatcaaac cggttttttc cttttttacg acgcctttaa 1398901 ttgctttgct tttgtttaac ggcatttttt ctttatatca tgtaccgctt atatttgata 1398961 ctgtcaaaac agatccgttt taccatacat taatcacttg gcttatcttt gtgcttgcgt 1399021 tcttcatgtg gtggccgctt gttcataagg ttgagcgtct acggcagctc agcggcttga 1399081 tgaagctggg ttatattatg gcggacggta tgctgctcac acctgcttgc gccttgatca 1399141 tgttcagcgg tgcaccgtta tacgccacct atacagatcc ggctttatgg gctgaggcaa 1399201 tgaggctttg cgtgccagcg gatatgatgg ggcaggtccc attaacaggg ccagagatgt 1399261 tgaatacact gcctttgtta gaggatcagc agctcggagc agtcatgatg aaaatcattc 1399321 aggaaattgt gtacggtact tttttggccg ttattttttt ccaatgggtg aagaaagaaa 1399381 gggaaaagga cgggcaggag gagccgccgt atattcagca gacgatatca taaaaggtac 1399441 agcgaaatat gctgtacctt ttcgttacat ttgaactgtt tttaacatgt tggctatgtc 1399501 ctgaatcagt gccttgcttt ttgtcacaac ctgtacggga aactcttccg tttctccata 1399561 ttctactcca tgagggtagt aatgctttcc taggagaggg gacattaatt gaatcacggc 1399621 gcgcccgctt ccgacatcgc cttctgccgc aataccttgt atccgcaggt aaaacgtacc 1399681 ctcaatcgtc gaaaacttct tgtcataggt gactctctcg taatcccatt gacccgctct 1399741 gataagacct ttgctttcca ttaagtcgtc tagccagctg agctcagcct taaccccttc 1399801 aagtccgctt tcagtaaact tcaacactga cccctcctta taaaaattac ctttcctgac 1399861 aatcatagta tgaaagcgtt aaactttcaa tgaatcttct tcttttgaaa gtatgcaaaa 1399921 attaaatttt gacgacaata gcactagact aaaggaggtt aaacggatga caaaaataaa 1399981 agatctgatg acagccgact tgcaatattg cacggtatta gataatgtat atgaagctgc 1400041 agtaaagatg aaggacgcaa atgtaggagc gataccggta gttgatgagg acggggaaac 1400101 attggtcggc atcgtaaccg accgcgatct cgtattaaga ggaatcgcca tcaaaaaacc 1400161 gaactcgcaa aaaatcactg acgcgatgac tgaaaaacct gtcagtgtgg aggaagatgc 1400221 ttcagtcgat gaggttcttc atttgatggc atcgcatcag ctcagaagga taccagttac 1400281 aaaaaataaa aaactgactg gaattgtcac gcttggtgat ctttctttat ctgagcaaac 1400341 gaatgaacgt gccggcagcg ccttatcgga tatttccgaa ggggataata gagaagaagg 1400401 cttttttcat taacacataa atctttgaca tgttaaatag gctgtattgt aatgggatgt 1400461 aaacaagaga ttgtgaatcg ccacgggggt gatagattga aaaatatatt gagagcaatg 1400521 gttatccttt tgattatctg cggaacctat gttctgttta ttcaatatgg atctgttcct 1400581 gaaaagaaat caaatgacag cgagcctcag gtgtcgaatg aggaagcgca aagcggcaaa 1400641 cgaatacata tgccgacttc agggttattg tccttcatgg gcaagcacgc cgatgaagta 1400701 acgaaaaagc ttggggaacc tgaacgtatt gacccttcgg cttatgatta cgattggtgg 1400761 gtatacaatc aaggtaagga tcaatatatc caaatcgggg tattaaacaa taaagtggtc 1400821 acattattcg cgtcgggtaa tgatattaac gccaagcctt tcaaaattgg agaatcaact 1400881 ggcgaagtat tcaagaccac ccaggtggca ccatttgtga atgtagagta taaaggaaat 1400941 tcctatcggt ttgaattttc tgaagaagat atcaatacaa gaccgactgt aaaggtagga 1401001 aagatgtatg tccagctgta tatggacaaa tttgagggga agctatccag catcagggcg 1401061 tttgatgcgc agacctttgt aaagcaaaga ccttatgagg tagtgtaccg cggggaatta 1401121 attaaaccga aagccgtttc agatgagaaa tggaaaaaga tccaaacaac gagcgaaaag 1401181 caaatccttg atttgacgaa tgtcatacgc gttaaacatg gacttgcgaa gcttgagtgg 1401241 gatcagccaa cggcggaagt ggcatttggg catagtgagg atatgaagga aaataattat 1401301 ttctcccatg tctctaaaaa atacggctcg ctgaaagacc gcttagaaga agggcatgtt 1401361 gattttcagc aagcgggaga aaatatcgca tacaattatg tggacggtcc ggctgctgta 1401421 gaaggctggc tgaatagcga aggccatcga aaagcgcttc tgaattcaga ttatacgcat 1401481 cttggtgtcg gagtagaccg gaaatattac acccaaaact ttattaagcg atggtaatga 1401541 aagccgcgga cgaatggttc ccggcttttt ctatttccat acaagctggt ctgaatgaat 1401601 gtgctgatag cttacagata aggccgtttc ccatcccttc agtcaggctt tttcaccagt 1401661 gtatagggat atcgctaaaa attcatttgg gaatgaatat aggcgaacac aatgcccgac 1401721 aaaacgatac attgtagtag gtaacgattt tcggaggggg tgaggattgt ggcgaatcaa 1401781 catgccaatc attcaatcaa tgactttaaa caattcgtca aaaagcatcc caagctgata 1401841 aaagaagtgc gcaaagaaca aagaagctgg caggacgtat atgaaaattg ggtcctcttc 1401901 ggggagagcg acccgatttg ggatccatat cgggaaccgg aagaagcttc tgaagctgtg 1401961 cctgaaacac cgcaaaaaaa tgattttgtc tcgaaaatgg tgacagcggt gaaaaagatg 1402021 gatgtcaatc aaatgaacga acaaatcaat aaaatgagcc agtcgatctc atcgttgcaa 1402081 agccttctta atacattttc cggaagcgga cagaagcatt ctcagccagg ctctggacag 1402141 catccttttt cttttcgaaa ggattaaaaa aggggagctc atatgcgcaa agaggttcag 1402201 gaatatattt tagcaaacga agaacggaaa cgattcatca gagaacagcc gatatggtac 1402261 cgcaggcttt caagaaaacc ggatgatctg tcctcctttc agcttgaaat gatgaatttt 1402321 tatgaaaaaa ccattccgca tcgggtgaat cagtttacga acgggattca aatggcgcaa 1402381 atgatgatgc aaatgtttca agcgatgcgg acaaaagatt aaaaggcccc gaagaagggt 1402441 cttttttcat gcggtcataa ggttttgttg gcggctgcgg ttaagcattt tccaattggc 1402501 tggtttcatg gtaaactaac aactggaggt gcatgttatg tatgcgacga tggaatccgt 1402561 gcggcttcaa agtgaagctc agcagcttgc cgagatgatt ctgcagtcgg agacggctga 1402621 gaactaccgc aattgttaca agcgtctcca ggaagatgaa gaggcaggtc ggattattcg 1402681 ttcttttatc aaaataaaag agcagtatga ggatgtacag cgttttggca aatatcatcc 1402741 tgactataga gaaatatccc ggaaaatgag ggagatcaaa cgtgagctgg acctgaacga 1402801 taaggtggct gacttcaaga gagctgaaaa tgagctccag tccattcttg atgaggtcag 1402861 cgttgagatt gggacagctg tttcggagca tgtgaaagtt ccgactggga acccttattt 1402921 tgacggtttg tcttcatgcg gaggcggctg cggttcaggc ggaagctgcg gatgtaaagt 1402981 gtcctgacga gactggccgt ctcgtctttt acatataaga gaaaacaggc aggtgattgt 1403041 attggagaat aggcgccagg gcatggttgt gtatctgcac tccctaaagc agagcaaaat 1403101 gctgaggaag ttcgggaatg tgcactatgt atcaaaacga ttaaaatatg tcgtactgta 1403161 ctgtgatatg gaccaaattg aaaaaacaat ggacaagatt gcgtcttact catttgtgaa 1403221 aaaagtggag ccttcttata aaccgttttt aaaattggaa ttcgagtcaa agcttgataa 1403281 ggcaaaagaa tacgattata aaatcggcat atagctataa aaaaatcccc gcaggcatct 1403341 gcggggtcct tctattcctt aatatgttaa ggagaaggca aagggagagg agaaaccgga 1403401 ggaagaactt atggggaaac gtaagtcttc tccgcggttg gcaacaacat cctctagatg 1403461 ctgttgctta tagtatggac aaggatcatg ctgcctatac acctgtttat caagattagc 1403521 gttcattgtt tggaagaatg ctttatgtta agataggatt gatttttttc tatgtacata 1403581 gcggcgtccg gccgaataaa gaaacaaaat agcttttaga aaaagtggtg tggaacatga 1403641 gagtaatttc tggatcaaaa aaaggccgtt cactaaaggc tgtagccgga acatcaacaa 1403701 gaccgacaac cgacaaagtg aaggaatcca ttttcaatat gatcggccct tattttgacg 1403761 ggggcagggg acttgactta ttcgcaggga gcggaggtct tggaatcgaa gcgctttcac 1403821 gcgggtttga gcattgtata ttcgttgacc gtgattttaa agcgattcaa acggtaaaat 1403881 ctaatttgaa aacgctggag cttacaaaac atgcacaggt ataccgcaat gatgcggaac 1403941 gtgctttgca cgctgctgct aaaagagaaa ccggctttcg cggaattttt ctcgatccgc 1404001 cgtataagga acaaaagctg aaagcacttt taactttgat tgacgaatat caaatgctgg 1404061 aagaagacgg ctttatcgtc gctgagcatg acagagaggt cgagcttccc gaaaccgtag 1404121 gagatcttgt gatgacaaga aaagaaacct atgggttaac aggtgtagcg atttataaaa 1404181 agagggggta gtgaggtggc gagtatagct gtctgtcccg gcagttttga tcctgtgacc 1404241 tacgggcatc tggacatcat caaacgcggg gcgcatattt ttgaacaagt gtatgtatgt 1404301 gtgctgaata attcttcaaa aaagcctttg ttcagtgtgg aagaacggtg tgagcttctg 1404361 agagaagtca caaaagacat tccgaacata acagttgaaa catcgcaagg cctgttaatt 1404421 gattatgcaa aaagaaaaaa tgcgaaagcg attttaagag gcttgagagc tgtatctgat 1404481 tttgaatacg agatgcaggg gacatcagta aaccgggtgc ttgatgaatc tattgagacg 1404541 ttttttatga tgacaaacaa tcaatattcg tttctaagtt caagcatcgt aaaagaagtg 1404601 gcaagataca acggctcggt atcagagttt gtaccgccgg aagtagagtt ggcgcttcag 1404661 caaaaattca gacaaggatg agggttttga ctcatccttt ttttgttccg tttgtcagtc 1404721 tgtaagaaaa aatgataatg tacgtaaaca gcgcgcatag tgtgacagca ggtccgatct 1404781 gcacaagcag attccagccg tttataaagg cagttgacat gtcactgctg ttaagagatt 1404841 taaatacata ctgatacgga tcatgccatg ctgtgtaaag aggtttccat aaaagcatga 1404901 cgaagacagc ggcataaacg ccctgcagca aacgtgcgat aaagaatggt ttaaatctaa 1404961 tgtcggtttc cgataaaata cctgccacct gagcttgtac ggaaaagccg ctaaacccaa 1405021 gaataaagct gacgataatg gctttttgca gaagagaaac atctgtctcg ctgacaagct 1405081 tgctgcctaa tgtaatttca aacatccctg ataaaagcgg aatgtccaat tgagtcggaa 1405141 gctgaaacaa agtcagtgct ccttttgtga aaacagacaa aacatcagtc agctggacca 1405201 ctgacaacag ccgattgaag acagaaaata aaataataaa gccgcctacc ataagaagcg 1405261 tttgaacaga agacgtcacg gcgtcgccta aaattttacc taagggccgt ttttctgcaa 1405321 gtctggcggt atgaagagcg tgtaaagcat ctttgactga agggaaaggt atcgttttct 1405381 ttcttctgag atgctgctct tccttgcggc cataggagcg cattgttaaa ccgacggcaa 1405441 gattccccaa atagtgtgca gaagctaata aaatgcctag tgatgcgttt tgaaagaaac 1405501 cgacggcaac agcgccgaaa ataaagagcg ggtttgaaga attggtaaac gacgcgagcc 1405561 gttctgcctc tactcttgaa atctgatttt cctgccgcag acgggcagtg agttttgcgc 1405621 ccgctgggtt tcctgatgcc attcccatag caagaacgaa gccgccgaca cccggcacgc 1405681 gaaagatcgg ccgcataaaa ggctcaagca aaacaccgac aaaccgcaca atgccaaagc 1405741 cgattaagag ttcggacaga ataaaaaatg gcagcaatga cggaaacaca acctcccacc 1405801 acatagacag cccggtttta gaggcttcga atgaggcctg tggatgtgag atgacagtcg 1405861 ctgttaaaaa aagaaaaaac gaggcaatca aaagtgtatt aatcttcgac aagttcattc 1405921 ttacctcccc gatgctaaaa atgcccaatg acatgtatat catgataaaa taatgtatga 1405981 tgtaaaacgg ccaagcagta cctgtcctct tgattctttg tactaatata cgagcatagg 1406041 ggttcagttt agaccataga attcggtata cagggaattc aggcaggagg ttaacgcttt 1406101 ggccaaacct aaaatcgggt tagcgttagg atcgggaggg gccagagggc ttgctcatct 1406161 cggtgtgctt tccagtttac ataagcacca aattgaagtg gatatgattg caggaagcag 1406221 catgggcgct ttggtgggca gtttttacgc cgccggacat gacgtggcaa cgatgaaaaa 1406281 agtagccaaa gcctttaaac gaaggcttta tgctgattat acggtgccga aactcggttt 1406341 tttaaaaggt gaccgcgtca gacagcttgt gcatgcttat acattcggaa aaccgattga 1406401 agagctccaa atcccgctgg gcattgttgc gtgtgatcta cagacgggag aaaagattgt 1406461 gttccgaaaa ggatcagtgt cagatgcagt gagggccagc atcagcatcc cgggtatctt 1406521 tattccgcag cggctggacg gacgccttct tgtagacggc gcggtcgtcg atcgaattcc 1406581 ggtttctgtt gtgaaagaca tgggagctga tattatcatc gcttcggatg tttccagggt 1406641 tcgaaaaact gaaacagcag tgcatatttt tgatgtgatt atgcaaagta tggatatact 1406701 gcaaaatgaa ttagtgcggc atcaaacaat tgccgcagat atcatgattc gcccttccct 1406761 tgaaacatac agctcaagct cgtttgccaa tattgaagaa atgatatcgg caggcgaaga 1406821 ggcgacaaac cgaatgatca gcaagataag aaaagaaata gagaattggg agggctcata 1406881 atttgctacg taaaaaacat tttagctgga tgctcgtcat cctcatactg atcgccgttt 1406941 tatcatttat aaaacttcca tactatatta caaaaccggg agaagcgaca gagcttgctt 1407001 cattgataaa agtggaggga ggctacccgg aaaaaggaag tctgtcctta atgactgtta 1407061 aagtgggacc ggctaatcca tttacatatg tgtgggcaaa gatgcaccct tattatgaaa 1407121 ttgttcctga tgagagcatt aaggaggaag gcgaatcaga taaggagtat atgaaaagac 1407181 agctccaaat gatgaaaagc tcgcaagaaa atgcggttat agccgcctat caaaaggcag 1407241 gaaaaaaagt cagctattcc tttaacggca tatacgcaag ctcagttgta gaaaacatgc 1407301 cggcaaaagg gaaaatagaa gtcggtgata aaatcatcag cgcagacggc aaaaactatc 1407361 agtctgctga aaagctgatt gattatatca gcagcaaaaa agcgggagat aaagtcacgt 1407421 taaagatcga aagagaagaa aaagaaaagc gtgtcaccct tacgttaaaa caatttcctg 1407481 atgagccgga tcgggcagga atcggagttt cgctttatac agacagaaac gtgaaggtag 1407541 agcctgatat tgattttgaa atcgaaaata ttggcggccc gtcagcaggg ttaatgatgt 1407601 cccttgaaat ctataatcag ctgacaaaac cagacgaaac aaaaggctac gatattgcgg 1407661 gaacaggtac gattgatgtt gacggaaaag taggcccgat cggcggcatt gatcaaaaag 1407721 tcgtcgccgc agacaaagcc ggaaaagaca ttttcttcgc gccaaatcaa aacggcgcca 1407781 gcaattccga ttataagaac gcagtaaaaa cagcaaaaga tattgattca aatatgaaga 1407841 ttgtgcctgt tgataccatg caggatgcga ttgattattt gaataagctg aaagcgaaaa 1407901 gcacctgatt ctcaggtgct ttttctatac atttaaaaag tgttgttcat cttcgtcata 1407961 tcgaatcggt gcatgtccgt attcctgtag gtcaaactca gttctcagcg gctcttctat 1408021 cggcaggctg taaatcctgc ttgcttttac gtccagatcg agagctggat gggagaaaga 1408081 ggacagtttg ctgacaagcg gaacagacag tgcttttttc ttttcggata aataagcctg 1408141 tccttttttc gtcatgccga gaagcctgat atacggcgcc ttatcgttgt caagcagctt 1408201 ttgcatatcc tgtttttttg ttctggttaa aatgtgtgta ttcatccgct ggagccttgt 1408261 ccacgtatag cgttttgttt tcagcagttc cataaattcc tgataggagc tggattttct 1408321 gatcgaacga ataattctgt gctctaaacc ttcctccacc tcgtatactt gctgtaattc 1408381 ccgtgccgtt acagttgaaa ggctgtattt taagtaagaa aagtagcttt caggtgtatg 1408441 ccacaatccg aaagatttgc ggtaagctgc taattcacgt gcagatgcag cagggagaaa 1408501 acgaaggcag gcttcgagat tctggccaat catcgctttt ctaatgcttg tggcacttgc 1408561 tatatggttt tcgccttcag ggagatcggc atcatgatag tccgaagaga ttcgtgccgt 1408621 agtataaggt ttcataggat atcccccggt tagaatcgag gtcacatact ggtatcccaa 1408681 aatgttattt ggttttgaca agtcaagtgc actttcagta tgcaaaatgg agctgaaggc 1408741 gatagccgcc gctgctgggt aactggcccc ctttttaagt tcttctttaa ttcggtcatt 1408801 caatatatgt ttatgctcat caataagctg tgctgtttct aaaaaaggct tgatatcccc 1408861 attttcactc ccgaaaaaca gcgcctcaca ttcaagttcg ttcaggatgg aaacactgcc 1408921 gcgtgcaaaa atgtctgctt tttgcacggc ataaagataa ggcagctcaa tgacaagatc 1408981 aactccgctt tgcagcgcca tttttgttcg ggcccatttt gatacaacag cgggttcccc 1409041 gcgctgtaaa aaatgtccgc tcatgaccgc gacagccgtg tcacatccgg tttgcagctt 1409101 tgctgtttgg gcatgataaa ggtgaccgtt atgaaaggga ttatattcaa ccaccaatcc 1409161 gacagctttc atattttttc cgcctttctt gctatgttta aaaacgtatg gtacatttgc 1409221 aaatgaaaac tcttacgcct tatttttgtt ttaagtgtat gcatagcata ttccgctgtc 1409281 aacgatactt caatggcagc attatgctgt aaagaaaaaa tattgacaaa aacaatctta 1409341 aaagctataa tcatgtttgt tgctttcctg aggtgataca aatgaaatgg acgatttatc 1409401 agctgcatca aatgccaaaa caaagttttg agtttgatga aacagttgag ttaaatgagc 1409461 tgacaaagct gaattctgac attcgccgca tttctcccgt tcgggtgaag ggcagagcgg 1409521 atatcaaatc caaacaggtt tcgtttgatt ttacaatttc aggcgaaatg cttttgccat 1409581 gctcaagaac actcgttgat gttccgtatc catttgaaat ttcaacaaaa gaactgttta 1409641 tatttcatca cacggatgat atagaagatg atgacgttca cattgttgag gacgatacta 1409701 tcgacataac tccgatcgtg aaagaagaaa ttcttttaga aatccctatg caaatctttt 1409761 gtgaatctga acaagaaaaa ggagctgctc ctcaagaagg aaaggattgg caagtcattt 1409821 cggaagaaga caagaagaat caagttgatc cgagacttgc agcccttgaa aagctcttaa 1409881 aacaagatga tgaatcttaa ctctttaagg aggtgggaat aatggctgta ccttttagaa 1409941 gaacttctaa aatgaagaaa agattgcgcc gtacacattt caaacttaat gtacctggta 1410001 tgacagaatg tccgtcatgc ggagagatga agttgtctca ccgtgtatgc aaagcatgcg 1410061 gatcatacaa cggcaaagac ataaatgtaa aaagtaacta atgagaaaag cgcagggtga 1410121 aagccctgcg ctttttcttt ttctcttcct gtcagcttgc ggaaaatttg tgagtgcaaa 1410181 tagtctatct aatctattac cggcatatgt atgagataaa taagctgaca tggagggaga 1410241 ttgaatttga ccattacaag acaagatgct tggactcagg atgaggattt gctgctggca 1410301 gaagtggtgc ttcgtcatat tcgagaggga ggaacacagc tttcagcctt tgaggaggtt 1410361 ggaagggcgc tgaccagaac cgcggcagcc tgtggtttca ggtggaactc gtatgtgaga 1410421 aaacaatacc agtcaggtat agagcttgca aaaaagcaaa ggaaagaact gagaaagcaa 1410481 atcggcgttc attcggtcaa tatgccgaat tccatgaagc agactgcctc ggcatcgtca 1410541 gaaggaaaac gagatttgtc cattcaggat gtcattcaat ttctcgaaca attcaaagaa 1410601 acaccgtctg cacaagaatt tcagcttgaa agggaaaaat tgaaggagca aatccaatcg 1410661 ctgcaaaaag agcttgagga tttgcggagt gaaaatcaga cattgcggaa tcagctagag 1410721 atgacagaag aggattacaa ggcactgatc gatatcatgg atcgggccag aaaaatggtt 1410781 gtttcgaagg aagacggaag aatgaaaaaa gcggctcaag aaacgtaaag aaacgcctga 1410841 aatgaaccgg ccctatagta agaataggcc ggttgttttg atttctatgc agactctccc 1410901 ggtgtcattt cgcgatccat atcaggatgc cagatgagcg ggttttcccc tttgtcccgc 1410961 gccatatcat acttaacagt tttaaagttc attttgttcc aaaattccgc tgatttcatt 1411021 ctcggatttg tccggatcgg cattttgaat gattttgcaa attcaaccaa ggctctcccg 1411081 tatcccctgt tctggtagcc cggaagaacc tcaagcttcc acagctccaa ataatcctgg 1411141 cggttgtcaa aatagggatt cgatttgccg ttaacttgat acagactcat tcgtgctaca 1411201 agtttatcgc caaaataaat cccgtaaaaa ggcgaggtgc tgtcattttc aataatatta 1411261 tcctgaagtt cttcaagcat tgaaagctcc tgaatgccgt attctttgaa tttcttgaat 1411321 tcttccagcg ttttatagtt gataagcaga cgttctacct ttgtcaaaca aatctccccc 1411381 tttgttgttt ctacatatat tgtaaacgct ttatttaaaa aatccaaata tttaaacttt 1411441 aattttaagc acatgggatc tttgagaagt aatttcttct tacttctgct atgataatac 1411501 gtaaatgcta aattgggtgt gacatcatga aaattggaat tatcggcgga ggctccgttg 1411561 gtcttttatg cgcctattat ttgtcacttt atcacgacgt gactgttgtg acgaggcggc 1411621 aagaacaggc tgcggccatt cagtctgaag gaatccggct ttataaaggc ggggaggaat 1411681 tcagggctga ttgcagtgcg gacacgagta tcaattcgga ctttgacctg cttgtcgtga 1411741 cagtgaagca gcatcagctt caatctgttt tttcgtcgct tgaacgaatc gggaagacga 1411801 atatattatt tttgcaaaac ggcatggggc atatccacga cctaaaagac tggcacgttg 1411861 gccattccat ttatgttgga atcgttgagc acggagctgt aagaaaatcg gatacagctg 1411921 ttgatcatac aggcctaggt gcgataaaat ggagcgcgtt cgacgatgct gaaccagacc 1411981 ggctgaacat cttgtttcag cataaccatt cggattttcc gatttattat gagacggatt 1412041 ggtaccgtct gctgacgggc aagctgattg taaatgcgtg tattaatcct ttaactgcgt 1412101 tattgcaagt gaaaaatgga gaactgctga caacgccagc ttatctggct tttatgaagc 1412161 tggtatttca ggaggcatgc cgcattttaa aacttgaaaa tgaagaaaag gcttgggagc 1412221 gggttcaggc cgtttgtggg caaacgaaag agaatcgttc atcaatgctg gttgacgtca 1412281 ttggaggccg gcagacggaa gctgacgcca ttatcggata cttattgaag gaagcaagtc 1412341 ttcaaggtct tgatgccgtc cacctagagt ttttatatgg cagcatcaaa gcattggagc 1412401 gaaatacaaa caaagtcttt tgagcttttt cggtaacatg ctatactcat ttcggatcac 1412461 taactattta ttggagaaag gaagttctag aagatgcagc taactgaact ttccatcaaa 1412521 aatcagaatg tgtttgtaca gcactatata gatggcaaag aagaaatgtc ttcttttttt 1412581 gattacagta ttcatcataa ggacatgtgg cgcgaaagac tggaagactt atcttcccgg 1412641 tttttcgcaa gagaggaatt ggcggcgtac ttaacctctt accataataa attcggttca 1412701 agtgcgatgc agtctgctat tgagaagctg aaggacccgt caagtgccgc tgtagtcggc 1412761 ggacagcagg caggactttt aacaggaccg ctttacacca tacataaaat catttcaatc 1412821 attgttttag caaagcaaca agaaaaggaa ctgcaagtgc ctgtcatacc aatcttctgg 1412881 gtggctggag aagaccacga tttggatgag attaattttg ttcacacatc tgaagagaat 1412941 gggcctgtga aaaaaaagct gcctcagtct tattggaaga aatcatcagc agcgagtaca 1413001 tcgcttgatc aggaaaagtg tgccgcgtgg atagatgatg tttttgccgc ttttgaagaa 1413061 acagaccata cgaatacact tctcgacaat gtgaaacgat gtttaaggga atctgttacg 1413121 tttactgact tctttgaact gctgatcgcg gatttgttcc aagaagaggg cttagtttta 1413181 ttaaattctg gggatccggg gattaaaaag ctggaaacgg ccatgttcca aaagattctt 1413241 cgagaaaatg atgaactcgc ccgggctgta tcagatcagc aggccttcat gcgtcaagca 1413301 ggctacaaac cgattatcga gtccggaaaa gagcaggcga atctgtttta tgaatacgaa 1413361 gatgagcgtt ttttaattga aaaagataac ggccgatttg tcatcaaaga gcttgatcta 1413421 ggatggacga gggatgaact tcatacacat atggaagaac atccagagcg tttcagcaac 1413481 aatgttgtaa cgagaccgtt aatgcaggaa tttctcattc cgactttagc atttattgca 1413541 gggcctgggg aaatcaatta ttggggcgag ctcaaacagg catttgcggt gatgggcttc 1413601 aaaatgcctc ctgtcatgcc aaggctgaac attacgatac ttgagcggca tattgagaaa 1413661 aaactggctg aacggaatat ctcattacaa gacgcgattg agcgcggaac ggagaatcaa 1413721 agagagacat acttcgagcg ccagattccg gaagagttta cggcggtgat ggatcaggcg 1413781 aaaagccaaa ttgaagcgat tcacaaaacg gtccggcagg aggcgttaaa ggttgatcaa 1413841 agcttggaac ctttacttct gaaaaatgcc gcttttattc aggatcagct tcaattctta 1413901 gagcgcacgg tgatgaagcg aattgaagaa aaagaaggct acgtcttgaa ggattatgaa 1413961 agaattcaaa atagcattaa gccgcttctt gcgccgcaag aacggatttg gaatatcatg 1414021 tattatttga acaggtacgg tccaaaattc ttcacgacat tcaagaatct gccattttct 1414081 tttcaaaatc aacatcaagt tgtcaaactt tgaaataaag ttttaaagaa ccctgactag 1414141 ttcagggttt ttttttatgg gtaaacagtg taaaatgaag ttgtggagcg aagtggtgaa 1414201 tagtggtgag ttaaggagag aaagtggggc aagagatcat gtttatgggt gaatatcagc 1414261 ataccatcga tgcgaaaggc cgcatgatcg tacccgctaa attcagagaa ggcctaggtg 1414321 agcaatttgt gctgactaga ggacttgacc aatgtctctt cggctaccct atgcacgaat 1414381 ggaaacaaat tgaagaaaaa ctaaaagctc ttcctctcac aaagaaagat gcccgcgcgt 1414441 ttacccgttt cttcttttca ggggcgactg aatgcgaact ggataagcaa ggcagggtaa 1414501 atatcgcatc atctctattg aattacgcca aactggaaaa agaatgtgtt gttatcgggg 1414561 tttctaatcg aattgaattg tggagtaaag taatttggga acaatacaca gaagagcaag 1414621 aagattcatt tgctgaaatt gctgaaaaca tgattgggtt tgatatataa tgattcttcg 1414681 tgtataacac tctaaaaaca atttcaattc atcctgataa aaggtgggac caacacaata 1414741 tgtttcaaca caagacagta cttcttcgtg aaaccgtaga cggacttaat attaaaccag 1414801 acggtacata tgtagactgc acactcggcg gagctgggca tagtacatac ttattgcagc 1414861 agttatccga gaaggggcgt ttaatcgctt ttgaccaaga tgatacggca ttacagcatg 1414921 ctaaagaagt gttgtccgat tataaaggac agctcattct gattaaaagc aatttcaggt 1414981 atttaaaaga atatttgaat gaacaaggcg ttacagaagt agacggcatt ttatttgatt 1415041 taggggtgtc ctctccgcag ctggatacac cggagcgcgg attcagttac catcatgacg 1415101 caccgttgga catgaggatg gaccagtcgg ctacgctttc ggcgaaagaa gtcgttaatg 1415161 agtggcgcta tgaggatctc gtccgtattt tctttaaata cggagaagag aagttcagta 1415221 aacagatcgc cagaaaaatt gaggaggcaa gaatgaagtc tcctattcaa actacgggcc 1415281 aactggtcga tctaataaaa gacgcgattc ccgctccagc gagaaggagc gggggacatc 1415341 ccgctaaacg cgtgtttcag gcaatcagaa ttgccgtaaa cgatgaactt agggtgtttg 1415401 aagaagcttt ggagcaggca attgaggttc tgaagccagg gggcagggta tcggtcatta 1415461 ccttccactc gctagaagac agaatttgca aaaccacttt taaagaaaag tcgtcgcttc 1415521 cggaacttcc tccgggactt cctgttatac cggaagagtt tgaaccggag ctgaagctca 1415581 tcacacgaaa accgattacg gcatctcaag aagagcttga agagaacaac cgggctcgtt 1415641 ctgccaagct tcggattgct gaaaaaagaa aataacgaaa cgcgaacgca aaattaaaag 1415701 gaggtcatca gcctatgagc aatttagctt accaaccaga gaaacagcag cggcatgcga 1415761 tcagtcctga gaaaaaagtg attgtcaaga aaagggcttc cattactctc ggagaaaaag 1415821 tgcttcttgt cctctttgct gcggcggtgc tcagcgtatc gcttttgatc gtatcgaagg 1415881 cgtatgcggc atatcaaacc aatattgagg tgcaaaagct tgaggagcaa atttcatccg 1415941 aaaataagca aattggtgac ctcgaaaaaa gcgttgctga tttaagcaaa ccgcagcgca 1416001 ttatggacat tgcgaaaaag aacggcttga atttaaaaga taaaaaagtg aaaaacatac 1416061 aggaatgatt caaatgccaa aaaagaataa atttatgaat agaggagcag cgattctaag 1416121 tatttgtttc gctctctttt tctttgtcat cctggggaga atggcatata ttcaaataac 1416181 cggaaaagcg aacggcgaag tgcttgcgac aaaagcgaca gagcagcatg aaaagaaacg 1416241 gaccatcgaa gcgagccgcg gctcgatttt agaccgaaaa ggaaaagtca ttgcagagga 1416301 cacagcgacg tataaactga ttgcgattct cgataaaaaa atgaccactg atgtcaagca 1416361 tcctcagcat gttgtaaaca aagaaaaaac ggcggaagca ttgtctaaag tgataaactt 1416421 ggacaaggcc gacatccttg atatcttaaa taaagatgca aaacaagtcg agtttggctc 1416481 agctggccgg gatattacgt attcacaaaa gcaaaaaatc gaaaaaatga aactcccggg 1416541 catttcattt ttacgggata caaaacgcta ctatccaaac ggagtatttg catctaatct 1416601 aatcggctat gccgaggttg atgaagaaac aaatgaaatt tccggcgcga tgggattaga 1416661 aaaagtgctg gataagtatt tgaaggagcg ggacggatat gtgacatatg aaagcgacaa 1416721 atccggctgg gagctcccga acagcaaaaa taaaattaca gcgccaaaaa atggtgacaa 1416781 tgtatattta accattgacc agaaaattca aacctttttg gaagacagca tgacaaaagt 1416841 ggcgcaaaag tataatccga aaaaaatcat ggccgcagtc gttgatccga aaacgggcaa 1416901 agtccttgcc atgggacagc gcccaagctt tgatccgaac aagcgcgatg tgacaaacta 1416961 ctataatgat ttgatttcat atgcgtatga acccgggtcc acgatgaaga tctttacact 1417021 cgctgctgcg atgcaggaaa acgtgtttaa tgcgaacgaa aaatataaat cagggacatt 1417081 tgaagttggc ggagcacctg ttaaggatca caataacggt gtaggctggg gtccgacaac 1417141 atatcatgac ggcgtcctaa ggtcgtcgaa tgtcgctttt gcgaaactgg cgaaagaaaa 1417201 gctgggatat gaccgcctca atcaatattt gcacaaattc aatttttacc agaaaacagg 1417261 tattgatttg ccaggagaag tctccagcaa aatcaacttt aaatatgaat ttgataaggc 1417321 gtcaactgca tatggccaag cgtctgcggt cacaccaatt cagcagattc aggccgcaac 1417381 ggcaattgca aatgacggta aaatgatgaa accttatgtc attgaccata tcgttgaccc 1417441 tgataaagat aaaactattt atcaaaataa gccggaatca gccggaactc caatttctgc 1417501 aagtactgcg aaaaaggtgc gggatatatt aggagaagtc gttacatcga agatcggaac 1417561 agggcaagct tataaaatcg aaggttttga tgttgccggg aaaacaggta ctgcgcaaat 1417621 agccggtaaa ggcggatatt tagacggcac agataactat atcttttcgt ttatgggtat 1417681 ggcgccaaaa gatgatcctg agcttttaat ttatgttgct gtacagcagc cgcaactaaa 1417741 agcaggacaa agcagttcag atccagtatc agaaatcttc aatccaacaa tgaaaaatag 1417801 cctgcactac ctaaacatcg aaccaactga aaaatctgac tcagataagg aagaaacaaa 1417861 agcgcagaca atgcctgatt taacagatca aacggtagct gctgctcaaa agaaagcaaa 1417921 agaggagaat ctcacaccaa ttgtcatcgg cagtgatgtc gctgtaaaag aacagtatcc 1417981 gaaagcggat gaggaagttc tcaccaatca aaaggtcttc ctgaaaacgg gcggcaaaat 1418041 caaaatgcct gatatgacag gctggtcgag aagagaggtt ctgcagtacg gcgagctcgc 1418101 gggaattcat attgaagtaa gcggacaagg ctacgctgtc agccaaagtg ttaagaaaga 1418161 caaagaaatc aaagacaaaa ccgtaatcaa ggttaagttt aaaaatcctg attaaaaaga 1418221 aagccgtcgt tatgcaggct ttcttttttt atgccttcag aggagcatcg ttctacctgt 1418281 ccaaattcag gcataaaatg aaacaagcct aaataaggag tgaacggtct cttgcgcgtc 1418341 tcgaatgtaa cggttagaaa acgtttatta tttgttttgc tttttggcgt gatcgtgttt 1418401 ctgatcattg atacaaggct ggggtatgtt cagtttgtga tgggcgaaaa actgacttcg 1418461 ctagcgaaag attcctggag ccggaacttg ccgtttgagc cggagagagg cgagattctg 1418521 gatcggaatg gtgtgaagct cgcaacaaat aaaagtgcgc cgaccgtatt cgtcgtgccg 1418581 cgccaagttc agaatccgat gaaaacgagc aagcagcttg cggcggtgct caatatgtca 1418641 gaagaaaaag tatataaaca tgtgacaaaa aaagcgtcaa tcgaaaagat cactcctgaa 1418701 gggagaaaaa tttcaaatga gaaggcgaaa gaaatcaaag cgcttgattt aaaaggtgtg 1418761 tatgttgcgg aggacagtat ccgtcattac ccgttcggca gctttttatc tcatgtgctt 1418821 ggatttgcag gaattgacaa ccaagggctc cttggacttg aagcctatta cgacgatgat 1418881 ttaaaagggg aaaaaggttc tgttaagttt tatacagatg ccaaggggaa gaagatgcct 1418941 gatgaagcgg atgactatac gccgcctaag gatgggcttg atatgaagct gacagttgat 1419001 tcaaaggttc agacgataat ggaaagagag cttgataacg ctgaggccaa atatcatccg 1419061 gacggcatga ttgccgtagc catgaatccg aaaaacggag aaattttggg gatgtctagc 1419121 aggcctgact tcgaccctgc tgattaccaa tctgttgatc cgtccgtcta caatcgaaat 1419181 ctgccagtat ggagcacgta tgaaccggga tctaccttta aaattattac acttgcagca 1419241 gcccttgaag agcaaaaagt aaatttgaaa cgggatcaat tttatgataa agggcatgct 1419301 gaagtggacg gagcgagact gcggtgctgg aaaagaggcg ggcacgggct gcagacgtat 1419361 ctggaagttg tgcagaactc ctgcaacccg gggtttgttg aattaggcga gcgcttagga 1419421 aaggaaaagc ttttcaaata tatcaaagac tttggttttg gacaaaaaac ggggattgat 1419481 ctccaaggcg agggaacagg catcttattc ccgcttgaga gagtgggccc ggtggagcaa 1419541 gcaactacgg ctttcggaca gggagtatcc gtcacgccga ttcagcaggt tgcagcagta 1419601 tccgccgctg taaacggagg aacgctctat acaccttata ttgcaaagga atggatcgat 1419661 cctgttacga agaaaacggt caaaaaacaa tcaccaatcg caaagaaaca agtcatttct 1419721 gaggaaacat ccaaacaaat ccgctatgct ctagaaagcg tcgtcgcaga aggaaccggc 1419781 cgcaatgcat ttgtagaagg atatcgtgtc ggaggaaaaa cgggaactgc acaaaaggtt 1419841 aaagatggaa aatatcttga aaacaaccat attgtatcat ttatcggttt cgcgccagca 1419901 gatgatccga gtctagtcgt ctacgttgcg gtggataacc cgaaaggcac gattcagttt 1419961 ggcggaacgg tggcagcgcc tattgtcgga aatattatga gagacagtct gccggaactt 1420021 ggtgtgaagc cccggaaaaa tcaaatcgag aaaaaatacc aatggaacga cacaaaaaca 1420081 atagaagttc cgaatgttgt agggatgtct gtctcagatc ttgagtcact attggtgaat 1420141 ctcaatgtgg atgcttccgg gaaagggagc aaaatcgtta aacaatcgcc agctgccgga 1420201 acgaaagtaa aagaaggctc aaagatacgc gtgtatttga ctgaagaaga tgaaaaggag 1420261 gcagccgatt gattcgggct gcctattctt ttattgcaga aaaaatgctg atatctttca 1420321 agattagctg gatgtatcct tttatttacg ctaaaatatg aactgtatgc ttaaaatcat 1420381 taccacatca tttgatgtga cttcaatgat aaaaagaacg aattagaatg ttgagaggtt 1420441 tgatacgatg aaacttacaa agctgcttac atacttaaca accgaacctt ctgtaaacga 1420501 ctcacaagac cctgaaataa cttcaattga gatggactcc agggaagtaa agaaagggag 1420561 tctttttgta tgtgtaaaag ggtatacggt ggatggccac gattttgcgc aaaaagcagt 1420621 agaaaacggt gcagcggcta ttgtggcaga aagagaggtc gatgtgaatg ttcctgttat 1420681 tattgtccgg cagtcacttc gcgcgctcag cgttttgtct gatgcgtttt acggacagcc 1420741 gacgaagaag cttcagctga ttgggataac agggacaaac ggcaaaacat caacgaccca 1420801 catggtcgat gagattctga aaaaagcggg aaaacgcaca ggcttgatcg gtacaatgta 1420861 catgaaaatc ggagacgaaa cacttcctgt taaaaacacg actccggaaa gcgtcacgct 1420921 gcagaaaacg tttaagaaaa tgaatgacaa gcacgttgac actgcaatca tggaggtttc 1420981 ttcccacgct ttgtctttag gacgcgtcca tggctgtgat tatgatattg ccgtgtttac 1421041 gaatttaaca caggaccatc tggactatca taaaacgatg gatgagtacc ggcatgcaaa 1421101 aagcttgctc ttttcccaac ttggcggggc tttcaaccat gaacatccaa agcgtgccgt 1421161 cctgaatgct gacgatgagg cgagcgctta ttttgaaaag gtaacagctg cgcatatctc 1421221 tacatacgga attaaaaacg atgctgatgt gatggcgaag aacatcagta tcactgcaca 1421281 gggcacaagc tttgatctcg tgacaaacaa aggcacgaag cacatcacga tgtctctcgt 1421341 cggacaattt aatgtgtata acgtgctggc cgctgttgcg acatgtattg cagcaggcat 1421401 accgtttgaa atcatcactg aggctgttga agaattgcat ggtgtaagag gccgttttga 1421461 attggtcaat cagcagcagg agtttcctgt cattgtagac tacgcgcaca caccggacag 1421521 ccttgaaaat gtgctggaga catgcagaga catgacggaa ggaaagctat ttgtcgttgt 1421581 cggctgcgga ggagacagag ataagacgaa gcgcccgaaa atggctaaaa ttgctgtgga 1421641 gctggctgac gagccgattt tcacgtcaga taacccgaga agcgaagatc ctcgcgcgat 1421701 tttaagagat atggaagccg gagtagagaa cgcatactat cacagtattg caaaccgcga 1421761 gcaggcgatc tttttcgcaa ttgccaatgc caaaaaaggc gacgttgtcc tcattgccgg 1421821 aaaaggacat gaaacctatc agcagatcgg aaatgaaact ttcgattttg atgatgctga 1421881 agtagcggcg agagccattg ttgaactcaa taagaataag acgaattcat aggaaagaga 1421941 tgttactgaa taatggagct tgaaaagatt tttcatatgg aaaaaaatca tgaatatgat 1422001 aactacgtat gtcgtttgaa agaaacagga ggagaaaagg acaatgcttg agcaagtcat 1422061 tctgtttaca attttaatgg ggtttttaat tagtgttctg ctctctccga ttcttattcc 1422121 gtttttaaga agattaaaat tcggccagag tattagagaa gaaggaccga aatcacatca 1422181 gaaaaaatca gggacaccga caatgggcgg ggtcatgatc atactttcta tcatagtgac 1422241 aacaattgtt atgacacaga agttttcaga aataagcccc gaaatggtgc tgcttctgtt 1422301 tgttacgcta ggctacggtt tgcttggctt tttagatgat tacatcaagg ttgtcatgaa 1422361 gcgcaatctt ggattgacat caaagcaaaa gctgatcgga caaattatta ttgcggttgt 1422421 attttacgcc gtgtatcatt actacaattt tgcgacggat attcgcattc ctggaactga 1422481 cttatcattt gatcttggct gggcttactt tatccttgtg ctctttatgc tagtcggcgg 1422541 atcaaacgca gttaacctga ctgacggcct tgacgggtta ttatccggta ctgcggcgat 1422601 tgcctttggc gcctttgcca ttctggcatg gaatcagtct caatatgacg tagcgatttt 1422661 ctcagttgcc gttgtcggtg cagttctggg cttccttgta tttaatgctc atccggccaa 1422721 agtttttatg ggagatacgg gatcgcttgc attgggagga gccatcgtta ccattgccat 1422781 tttaacgaaa ttagagatcc tgctggttat catcggcggt gtattcgtta tcgagacatt 1422841 atccgttatt ttgcaggtca tcagctttaa aacgacaggt aaacgaatct ttaaaatgag 1422901 tccgcttcat caccattatg agcttgtcgg ctggtctgaa tggagagtag tcgtgacgtt 1422961 ttgggctgcg ggacttttgc ttgccgtttt aggaatttac atcgaggtgt ggttataagt 1423021 ggaaaatgat caatttttac agaaacagca ttttttaatc cttgggcttg cgaaaagcgg 1423081 atatgcggcg gcctccattc ttcatgaaaa aggcatttat gttgcagtca atgatcaaaa 1423141 gccttttgaa gaaaatgaac cggcacaaaa gctttctgaa aaaggaatcg aagttgtttg 1423201 cggagagcat ccagtttctc tgttcgatca gcatcaaatc acgattctga tcaaaaaccc 1423261 gggaattcct tatgaaaata tcatggttca ggaagcagag aaacgaggta ttccggtttg 1423321 gacggaaatt gagctcgctt actacctgac cagcgccaag tttatcggga ttaccggatc 1423381 gaacggtaaa acgaccacga caacgctaat ttacgaaatg ctcaaggctg actcgcaaaa 1423441 agcactgatt gccggaaaca tcggcacagt cgcaagtgag gttgcctatc atgctgatgg 1423501 agatgaatgg atcgttaccg aactgtcttc gtttcagctg atgggaacac acgctttcag 1423561 accggaaatc agcctgattt taaatgtatt tgacgcccat ctggattatc accatacgcg 1423621 cgaaaactat gaaaaagcga aacagaaagt gtaccttcat cagactgctt cagataaagc 1423681 tattgtcaac caggatgatg aaaccgtcgt gcgtcttgct gaagccggaa aagccgaaat 1423741 cgtcccattt tcagtcagca aaacgcttga acagggcgca tatgtaaaag acagtatgat 1423801 tatgtttaac ggcgaagcca ttcttcctct ggaagaggtt gtactgcccg gtgctcataa 1423861 cctggagaac attttagcag ctattgcagt tgtgaaaacg gcaggagcat ccaatgaggc 1423921 ggttaaaaag gtgctgacaa gctttactgg tgtgaagcac cgcctccaat atgtcacaac 1423981 tgtgaatggc cgcaaatttt ataacgacag taaagcaaca aacattctgg cgacaagcaa 1424041 ggcgctttca gcttttgata agccggtcat tctgcttgcg ggcggactgg atcgcggaaa 1424101 tggttttgat gacttgaaac cttatatgaa gcatgtcaaa gcagtgctta catttggcca 1424161 gacggcgcca aaactcgaga aactcggcaa tgaactggga atacaacatg tcaaacgtgt 1424221 cgataatgtt gaacaagcag tatctgcggc gtttgcgctc tcaaatgaag gagatgtcat 1424281 cctgctgtca cccgcgtgtg cgagctggga tcaattcaaa acatttgaag aacgcggtga 1424341 catgtttata gatgccgtgc atatgcttaa gtaagggctt gtcttgaagt aaatcggcag 1424401 ccctaatgac tttaagcttg gggtgtcgat tgctttgact actaaaaaaa catcgcctga 1424461 tttgttattg gtcatcatta cgttattatt attaacaatc ggattaatta tggtgtacag 1424521 tgcgagtgcg gtatgggcgg attataaatt tgacgactca ttctttttcg cgaaacggca 1424581 gcttttgttt gcgggaatcg gcgtcattgc tatgtttttt atcatgaatg ttgattattg 1424641 gacttggagg acatggtcca aattgctgat ggttatctgc tttttccttc tggtgcttgt 1424701 tttgataccg ggcgtcggaa tggtgcggaa cggttcaaga agctggatcg gagtcggagc 1424761 attcagcata cagccttcag agtttatgaa gcttgcgatg attgcattcc ttgctaaatt 1424821 tctctctgaa aaacaaaaaa acatcacatc gttcagacgg gggttcgtcc ctgcacttgg 1424881 catcgtgttt tcagcatttt tgattatcat gtgccagcct gacctcggaa cggggacagt 1424941 tatggtcgga acttgtattg tcatgatttt tgtagccggc gcacggatcg cccatttcgt 1425001 ctttctcggg ctgatcggcc tcagcggatt tgtcgggctc gtactatcgg ctccatatcg 1425061 gataaagcgg attacctcat acttaaatcc atgggaagac ccgctcggaa gcggatttca 1425121 gatcattcaa tcgctttatg cagtggggcc cggcgggttg ttcggaatgg ggctcggaca 1425181 aagcagacag aagttctttt atctgcctga gccgcaaaca gactttattt tcgccatctt 1425241 gtcagaggag ctgggcttta tcgggggaac acttattttg ctcctcttca gcgtcctgct 1425301 gtggagagga atcagaattg cgcttggtgc gcctgatctg tacggaagct ttgtcgcagt 1425361 cggcattatt tcaatgattg ccattcaagt catgataaat atcggcgtag tcacgggcct 1425421 gattcctgta acaggcatca cgctcccgtt tctgagctac ggaggctctt cattgactct 1425481 aatgctgatg gcagttggtg tgctgctgaa tgtaagccgc tactcgaggt attaacgaat 1425541 gtatttccaa gcctcctgtc taacatgaag cttggaaaca attgatgcga taaccctgtc 1425601 caacaaaaca gggttatcgt tatgttatag agaaacttag actgggggaa aaaagaaatg 1425661 cgaattgcaa taagcggagg cggtacaggg ggacatattt atcctgctct tgcttttatt 1425721 aaagaagtgc aaagacgtca tcctaatgtg gaatttttat atatcggaac agaaaacggg 1425781 ctggagaaaa aaattgttga gcgggagaat ataccgtttc gttcaattga aattacagga 1425841 tttaaaagaa aattgtcatt tgaaaatgtc aagactgtga tgcgttttct gaagggcgtc 1425901 aaaaagagta aatcgtattt agcggaattt aagcccgatg ccgtaattgg aacgggcggt 1425961 tatgtatgtg ggccggttgt ctatgccgct gcgaaaatgg gaattccgac tattgtccac 1426021 gaacaaaaca gcctgccggg catcacgaat aagtttcttt caaaatatgt taataaagta 1426081 gcgatttgtt ttgaagaagc gaaatcacat tttcctagcg agaaagttgt atttacggga 1426141 aacccgagag cctctgaagt cgtctcaata aagacgggac gatcattggc tgaatttggg 1426201 ctttctgaag acaaaaaaac ggtcttaatt ttcggcggaa gccgaggcgc tgcaccgatt 1426261 aaccgcgctg tcattgacat gcaggatgtg ctgaaaacaa gagactatca agtgctgtat 1426321 atcaccggtg aagttcacta tgaaaaagta atgaatgagc tgaaaagcaa gggtgccgct 1426381 gataatatgg tcacaaagcc gtttcttcat caaatgcctg agtatttaaa ggccattgat 1426441 gtcattgtgg ccagagccgg tgcgacaacg attgccgaaa ttactgctct cggaatccca 1426501 agtgttctga tcccaagtcc atatgtgaca gcgaatcacc aggaggtcaa tgcgaggtct 1426561 cttggccagc atgatgcggc gattgtactg aaagaaacag agctcagcgg ggagaagctg 1426621 attgaagcgc tagaccggat tgtactgaat gagcaaacgt taaaggaaat gagcgaacga 1426681 acaaagtcac tcggtgttcc tgacgcggct gcccgtttat acagcgtact cgaggaatta 1426741 aaaaaatagt agaaaagcaa atggaatgcg gaggtttacg atggagaaag tgatacagga 1426801 attaaaagaa cgagaagtcg gcaaggttct tgcaaatgaa ccgctcgcga atcatacaac 1426861 gatgaaaatc ggcggacctg cggatgtatt ggtcattcca agcagtgtgg atgctgttaa 1426921 agacatcatg gacgtgatta aaaaatatga tgtgaagtgg acagtcatcg gccgcggatc 1426981 aaatcttctt gttttagatg aaggaattag aggcgtagtg atcaagctgg gggcgggtct 1427041 tgaccatttg gagcttgaag gggaacaagt aacagtcgga ggcggttatt cggtggtccg 1427101 ccttgctaca tcattgagca aaaaaggcct gtccggtttg gaatttgctg ccggcattcc 1427161 aggatcagtc ggcggagcgg tttatatgaa tgccggcgct cacggttctg atatgagcga 1427221 gatcctcgtc aaagcgcata ttttatttga agacggaacg attgagtggc tgacaaatga 1427281 gcagatggat ttcagctaca ggacatctgt actgcaaaag aaacgcccgg gcgtttgcct 1427341 tgaagctgtt ttgcagcttg agcagaagga taaggaatca atcgttcagc aaatgcaaag 1427401 caataaagac tatagaaaaa atacacagcc gtattcaagc ccttgtgcgg gaagcatatt 1427461 cagaaatccg cttccgaatc atgccgggaa ccttgtagaa aaagcaggct tgaaaggata 1427521 tcaaatcggc ggtgcaaaga tatcggagat gcacggaaac ttcatcgtca atgcgggggg 1427581 agcatcagca aaagatgtgc ttgatctcat tgaccatgtg aaaaagacaa tccgtgaaaa 1427641 atacgagatt gatatgcaca cagaggttga aatcatcggc ggaaatcgct gattcaagtt 1427701 ctgactgaag ctgttcatat gatatactgt aagcaaacga caaacggcat catagtatgc 1427761 cgtttgtttt ggaatagaca gacttttaac agctgtttca tttgaatgag gtgaacaggc 1427821 aatgaacccg ggtcaagacc gagaaaaaat cgttaacatt gaagagcgga tccctaaaat 1427881 taaagagcag aggaaacaaa aggcaaaccg ccgtctcatt tcatttatta tgctcttttt 1427941 tattatggtg ctgatcattg tgtacctgca aacaccaatc agtaaagtat caacaatctc 1428001 tgttacaggg aatgaaaatg tatcaaaaaa ggaaattatc gacctttccg atattaacag 1428061 cggagatact gagttttgga gtttggacaa gcaaaaaaca gaaaagaaga ttcagcaaaa 1428121 taaattagtg aaaaaagcgg agatcagcaa atcgcttcct aataaaatca acattgcaat 1428181 cgaagaatat aaagcgattg cttatttaga aaaagacgat gtgtactatg aagtgcttga 1428241 aaacggctca gttctgccaa acgaagtaac gccggatgat gccggaccga ttttagtgaa 1428301 ttggacaaac gcgaagaagc ggtctcaaat ggccaagcag ctcgatgcgt tgtcaaattc 1428361 gttaaaacag tcgatttcag aaatttatta tacgcctgta aaaatggatg aaaaccgtat 1428421 taagttgtac atgaacgacg gttatgttgt tacggcatct attaaaacgt ttgcagaccg 1428481 aatgaagacg tatccttcta tcatctcaca gctaagcagc aataaaaaag gaatcattca 1428541 tttagaagtt gccacctatt ttgaagagtt tgggaaaaac gataaagctg ctaaaaagga 1428601 agatgaaaat tgaggggcaa atcagcagtc cttctttcct tgattatgct tatcgcaggt 1428661 tttttgattt cattttcttt tcaaatgaca aaagaaaaca acaaaagcgc ggctgagacg 1428721 gaagagtgga aaaaagaata tgcgctgaga gatgaactgc tgaaacaaga gaaagaaaat 1428781 aagaagtttg aaaaagaatt atatcaaaag caaaacaaag tccgccaggc ggaaaataag 1428841 ctgaagaaag agaagtcgga atactataat gtcctcgaag atacagaaaa atacaggatg 1428901 tatattgggg aagtcggtgt gcagggagaa ggcgttgagg tgacattgga agatgcgtca 1428961 tacataccgg aaggggagaa tgtgaatagt tacatcgttc acgaaagcca tatcttccaa 1429021 gtagtaaacg aactgtatat ctcaggagcg gcagctgtcg ccgttaatgg acagcgtttg 1429081 acgcatgatt cgtatatcaa atgcaatggt cctgtggtaa cggtagacgg ggtgcagcat 1429141 cccgctccgt ttacggtatc cgctattgga gatccagatg tcctgctgcc ctcgttaaat 1429201 atcgctggag gcctaattga tcagctgtca atggatcata tttctgtgtc ggcagaaaaa 1429261 gagaaaaacg tacaaatgaa accgattctg aaaacgaagg aatgactgaa aaagcgggtg 1429321 aaatagattg aaaataaagc gttccttcat aagcatcagt gttcttatgg tcatcttcgg 1429381 cctgatgata tctgttcagt ttaattcgtt aaagcacccc aaagtccggg atacaagaga 1429441 tatgtgggat attagggaag agctgacatc agagcagaag aagcaggaaa agctgctggc 1429501 tgaaataaac aaatatgaca aattgctgaa tagctattcg caaacgaaag aaatgacaaa 1429561 agaaaccgcg ctaaataata ccttgcaatc cttaaaaaaa acagccggca tgaccgatat 1429621 aacaggtagc ggaattgtca ttacgatttc cccgcttttt tctgaaagct taacaggaga 1429681 gccgatcgaa aatccgcctc cggatttgct gaaaaagctg ataaatgaac tcaactccta 1429741 cggtgcagag catatctcga ttaatgagcg aagagttgtg aatcatacag tcatcagaga 1429801 tataaacggc actacaaaaa tagacggata cgcccttgac gattatcctt taacagtaaa 1429861 agtgcttgcc aaagatccgg acatgttaca cagcagagtg aaggggtcag gccttgagga 1429921 tctttttgca tctgaaaatt tagcattaaa agccggtaaa tctgaaagca aactaacatt 1429981 aaaagcatat gacagaccac tggacgtaca acagctgaaa ctgcttaaag actgaaaagg 1430041 aggagaattg tcatgtggct gcccgtgttg ggactggtgc tcggaatagc gattggacta 1430101 atgacaaact taacgatacc gagtgaatac tcaaactatt tatcgcttgc ggtgcttgcc 1430161 gcacttgata cattaatcgg cggaatcagg gcgcatttac aaggtacata tgatgaaatg 1430221 gtatttgttt ccggtttctt ttttaatatt atattggcaa taagtttagc ttttctggga 1430281 gtccatcttg gtgtagactt gtatttagca ggtatattcg catttggagt cagattattt 1430341 cagaatatag ccgttatcag aagaaatcta ctaacaaagt ggactctttc taaaaaaaat 1430401 aaaaaaaatg tgatataaaa gaggatatac ataggatata acgaatattt tcaataaaca 1430461 taaaatgtga aaagcacata aaaatattct gttgttattt tttgttacac acttgtaaag 1430521 ccacattcat tgtattgttg ttccgcaaat aatagaatag aaatgatcga aatgtgagga 1430581 ggtgccatag aatgaacaac aatgaacttt acgtcagtct tgacatcggt acgtccaata 1430641 caaaagtgat cgtcggagaa atgacagatg attcccttaa tattatcggt gtgggaaatg 1430701 taccgtctga agggttgaaa aaaggctcaa tcgttgatat agatgagacc gttcattcta 1430761 taagaaaagc gtttgaccaa gctgaaagaa tggtaggttt tccgcttaga aaagctattg 1430821 tcggcgttaa tggaaattat atcaatattc aagatacaaa cggtgttgta gcagtttcca 1430881 gtgaaaataa agaaattcag gttgaagatg tacgccgtgt catggaggcg gcacaggttg 1430941 tttccgtacc gcatgaacag ctgattgttg acgtcattcc taaacagttt atcgtagatg 1431001 gaagagatga aatcaccgac ccgaaaaaaa tgctgggtgt gcgtttagaa gtagagggca 1431061 ccttgatcac cggttcaaaa acaatcttac ataacttact ccgctgcgtt gaaagagctg 1431121 gtattgaaat aactgatatt tgccttcagc cgctggcagc cggttctgct gcattatcaa 1431181 aggacgagaa aaaccttggt gtggctctca ttgatatagg gggagggtca acaaccattg 1431241 ccgtattcca gaacggacat ctcacttcta cccgtgtcat tcctctcgga ggcgaaaata 1431301 tcaccaaaga tatctccatc ggattgagaa cgtcaacaga agaagcagaa cgcgtgaaaa 1431361 agcaacttgg acatgcctac tatgacgaag cctcggaaga tgaaatattt gaggtaaccg 1431421 ttataggcac caatcaaaaa caaacattta cacagcaaga agcagcgaat atcattgaag 1431481 cgagagtaga ggaaattctt gaaattgttt cagaagagct tcgcagtatg ggaattaccg 1431541 atctgccggg aggcttcgtg ctgacaggag gacaagcagc tatgccgggt gtcatgtctt 1431601 tggcacagga tgtgctgcaa aacaatgtca gagtggcaag cccgaattat atcggtgtaa 1431661 gagatcctca atatatgacg ggagtgggcc tgatccaatt cgcctgccgg aatgcaagaa 1431721 tccaaggcag aaaaataggc tttaagatgc ctgaagaagc gatacaggaa atcgcagtct 1431781 catcatctga ggaacaagag cagcatcatc accaaaatga ggtgcagcag cggccaaaag 1431841 gaaaacaaaa aacacaagcc gaacataata aacagagcaa aatgaaaaaa ctattaagca 1431901 tgttttggga atagatagat agtcattcgg cagattagga ggatttagca tgttggagtt 1431961 cgaaacaaac atagacggct tagcatcaat taaagtaatc ggagtaggag gcggcggtaa 1432021 caacgccgtt aaccgaatga ttgaaaatga agtgcaagga gtagagtata tcgcggtaaa 1432081 cacggacgct caagctctta acctgtcaaa agcagaagtg aaaatgcaaa tcggcgcaaa 1432141 gctgactaga ggattgggag caggtgcgaa tccggaagtc gggaaaaaag ccgctgaaga 1432201 aagcaaagag cagattgaag aagcacttaa aggtgctgac atggtattcg tgacagctgg 1432261 tatgggcggc ggaacaggaa caggtgccgc accggttatc gcacaaatcg cgaaagactt 1432321 aggcgcatta acagtcggcg ttgtgacaag accgtttacc ttcgaaggac gcaaaagaca 1432381 gcttcaggct gcaggcggaa tctcggcaat gaaagaagcg gtggatacac tgatcgtgat 1432441 cccgaacgac cgtatccttg aaattgttga taaaaacaca ccgatgcttg aagcattccg 1432501 cgaagcggat aacgtacttc gccaaggggt tcaaggtatt tctgacttga ttgctacacc 1432561 tggtcttatc aaccttgact ttgctgatgt gaaaacaatc atgtcaaaca aaggatctgc 1432621 tttgatgggt atcggtattg ctactgggga aaatcgcgcg gcagaggcag caaaaaaagc 1432681 aatttccagc ccgcttcttg aagcggccat tgacggtgcg caaggcgtcc tcatgaacat 1432741 cactggagga acaaacctca gcctatatga ggttcaggaa gcagcagaca ttgtcgcttc 1432801 ggcgtctgat caagacgtaa acatgatttt cggttctgtt attaatgaaa atctaaaaga 1432861 tgagattgtg gtgacagtga ttgcaaccgg ctttatcgaa caagagaagg acgtgacgaa 1432921 gcctcagcgt ccaagcttaa atcaaagcat caaaacacac aatcaaagtg ttccgaagcg 1432981 tgagccaaaa cgtgaggaac ctcagcagca gaacacagta agccgtcata cttcacagcc 1433041 ggctgatgat acgcttgaca tcccgacatt cttaagaaac cgtaataaac gcggctaatg 1433101 taaaggacaa aatcgttttc gattttgtcc ttttttgttt ttctcttcac actttccttc 1433161 ttataaagtc tttttcccta ttgcttcctt cgcgagctcg attatggatg gtttacgttt 1433221 tggaaaaagt aaggtatcct agttcgtaca aagttttatg aaaattaaaa caattataaa 1433281 aggcaataaa gaggaggacc acgatgattt tgcagcttga caatgtctca ctaaaacgga 1433341 atgggaaatg gatactgaaa gatattcatt ggaaggtgga agaaaaggaa aattgggtgc 1433401 tttacggcct aaatggcgcc gggaagacag cgctgttaaa tatgctttgc tcatattatt 1433461 ttccaacatc aggcgagatg caggtgctcg gccatgaatt tggcaaaaca gagcttgggg 1433521 aaaagctcag acgtaaaatt ggcctcgtct cagcagctct tcagcaaaaa ttgtatccgg 1433581 cagattcagc ttttgaaatt gctttgagcg gagcttacgc ttcgattggg ttatatgaaa 1433641 cgccaagtaa ggaaaccagg gaaaaagcga taggtttgtt agaggacttg ggagcaattg 1433701 aatatgccga tcgccgctat gaaacccttt ctcaagggga aaaacaaaga gcattgattg 1433761 ctagagcact aatggccgat ccggagctgc tgatactgga tgaaccagtc acaggactgg 1433821 attttattgc ccgggaaaag ctgttagata cgattacata cattgcaaac aaagaaaatg 1433881 caccatctat cctttatgtg actcatcatg ctgaagaaat tttgcctgtc tttgataaag 1433941 cccttttatt aaaacaggga gaggtttttg gatccggaga aataaaggaa atgcttactg 1434001 atcaaatact ttccgctttt tttgatacgc caatccatgt attatggaat caggatcggc 1434061 cgtttttaac aagagctgag ccgataacga atgcctgaca aatatatata gattcatcct 1434121 aggggtgctt tgcgaagctg agagagactt tgtctcaacc cttttgacct gatctggatc 1434181 atgccagcgg agggaagcgg tgaaaagcgg agtacatcgg actccgtttg tttttattaa 1434241 gccgtttcat cacatttgaa acggcttttt tgattttaaa gaataggagc ggatttacat 1434301 tggatcaaca aatatactct ttgcaaaaaa aagtggaaga acataaggag gagcttattc 1434361 agcttgcgaa aacgctgatt tcttatcaaa cacctgctcc gcctgcaaga aatacagagg 1434421 gcattcagtc ttggattgcg ggatatttaa atgaattggg attctcgatc gacaaatggg 1434481 atgtgtaccc tggagatccc aatgttgtag ggaagctaaa aggaacagat tcagcagatt 1434541 attatagcct gattatcaat ggccatgtag atgtggcaga ggtaaaagag gatgaagaat 1434601 ggaagcacga tccgtttcat cccattgaaa aaaacggtct cttaatcggg cgaggcgctt 1434661 ccgatatgaa gggcggaatg gcttgtgtgc tgtttgctgt caaattaatt cgtgaagcaa 1434721 gcattgaact tccaggtgat ctgattctgc aatcggttat tggggaggaa gttggagagg 1434781 ccggcacact tgaatgctgc aagaggggct accacgctga ttttgcaatt gtcgcggata 1434841 cgagcgatat gcatattcaa ggccaaggcg gtgtcattac aggctggatc gaaatcaaaa 1434901 gcagtcaaac atttcatgat ggaacgagac ggaatatgat tcatgcaggc ggaggaacat 1434961 tcggagcaag cgcaattgaa aaaatggcaa aaatcattgc ggggctcggt gaacttgagc 1435021 gccactggtc tattatgaaa agttatcccg gttttaaacc aggcacaaat acgattaacc 1435081 cggcagttat agaaggcggc agacatgcgg cttttatagc ggacgaatgc cggctgtgga 1435141 tcacagtcca tttttatccg aatgaaaccc atgaccaagt ggcagcggaa atagaagatt 1435201 acgtcaatcg gctgagtgac agtgatattt ggcttaggga aaaccgccct gtattcaagt 1435261 ggggaggctc atctatgata gaagacaggg gagaaatttt tccggcattg gaagttgacc 1435321 ctggccaccc aggcgtctta gcgctaactg cctctcatca gaaagtgaaa cgggagtgtc 1435381 caattattga cgtttctcaa tcagttacag atggcggatg gctgtatgat gccggtattc 1435441 catgcgtaat atacggtcct ggagatctgc acaatgcaca ctctgtgaac gagaaggtat 1435501 cgattgagca gctagtagag tatacaaaaa ttatactcga ttttatcatc agctggtgca 1435561 gccggaaaaa agaacaatga catgaaaatt tcttcttgct gacaaggttc agcctgcccg 1435621 ttcatatact tgaacaaaag gacggaaaaa ggacgtgatg gaatgatcag catttcagaa 1435681 tttcaggtaa aggatgtcgt caatgtctca aacggaaaaa agctggggag tattggtgat 1435741 attgatatca atgtgaccac tggaaaaatt caggcgatca tactcggagg aaatgggaaa 1435801 gttctcggat tttttggaaa agaagaggaa ttggtcattc catggcgaaa tatagtaaaa 1435861 atcggggaag atgtaatctt agtccgatta agtgaaccac atgcataaac ctgcttgtct 1435921 gccgcagatt ggcaaatgcc ggaagtctcg attcttccgg cacatttcat ttagaaatat 1435981 gcaaatcggc gctcaacgaa tgcagtaaga tgtggtaaaa taagtgggaa attccgcttt 1436041 tttaaatgtt tgtcgaaagg ttggatcatc atgaatacat atcacccatt cagtcttacc 1436101 acaccctcga cactcatgat acaagactgg gctcaaacga atcaaaacaa caaagaggtc 1436161 attgccggat ttacgacaaa aaacggcggt gtcagccaaa agccttttga atcgttaaat 1436221 acaggattgc acgttcatga caaagatgca gatgtagtta aaaatcgtga atatattgcc 1436281 gatatgttta atactgattt gcagtcttgg gtattcgctg atcagacaca tgataatcgc 1436341 gttcagaaag tgacgcagag ggatagggga aaaggcgccc gtgagtatca cacggctcta 1436401 aaagcaacgg acgggatcta tacaaatgaa aaaaatgtat ttttagcatt atgctttgct 1436461 gattgtgtgc ctcttttctt ttatgatccg gttaagtcgc ttgtcggagt cgcccatgcc 1436521 gggtggaaag gcaccgtcaa acagattggc agagaaatgg tgaagcaatg gactgagaag 1436581 gaaggttcaa atccctcaga tatttacgct gttattggcc cgtctatcag cggagcatgc 1436641 tatacggtag acgaccgcgt catggatgct gtccgcgcat tgccggtttc agcagacctt 1436701 gccgccaatc agacggcaaa ggcacaatat cagcttgatc tgaaagagct gaaccgtctt 1436761 atactgatgg acagcggttt ggcaagtgaa caaatttctg tcagcggttt atgcacggaa 1436821 agcgagccgt ctcttttcta ttctcatcgc cgcgatcagg ggaaaactgg acggatgatg 1436881 tcctttatcg gaatgaagga ggcataaaag atcttgcgtg ttgttgataa tttacgacat 1436941 ataaacgaac gaataaacga agcatgtaac agatcgggcc gcagctccga tgaagttacg 1437001 gttattgcag tcacaaaata tgtatcacct gaaagagcac aggaggcagt agatgctggc 1437061 atcacctgcc tcggagagaa tcgggatgcg gaactgctcc gcaaacagga attgatgaaa 1437121 gggaatccgg aatggcattt tatcggcagt ctgcaatcaa gaaaagcaaa atctgtcgtc 1437181 aattcggttt cctatatcca ttccctagac cggctctcat tagcgaaaga aattgaaaaa 1437241 cgggctgaag gtactgtacg atgctttgtg caggtcaata cctctcttga gccttctaaa 1437301 catggcatga aaaaagaaga agtcattcca ttcatacagg agctttccgg tttcgaacat 1437361 atccttgttg ccgggctgat gacaatggct ccgctgactg atgatcaaga tcagatcaga 1437421 agctgtttca ggtcgctgag agaactccgt gaccaggttc agaagctgaa ccagccgaac 1437481 gctccgtgta ctgaactgtc gatgggcatg tcaaatgatt ttgaaattgc aattgaagaa 1437541 ggagctactt atattagaat cggctcatcg ttagtcggaa atgaaacagg gggtgtacag 1437601 caatgagtat gaaaaataaa ctgaaaaact ttttctcaat ggaagatgaa gaatacgaat 1437661 atgaatatat tgagacagag cgggaatctc atgaggagca tgagcaaaaa gaaaagccgg 1437721 cttacaacgg gaataaacct gcgggcaaac agaatgtagt gagcttgcaa agtgttcaga 1437781 aatcctctaa agtggtgttg agtgagccgc gcgtttatgc ggaggcgcag gaaatagccg 1437841 accatttgaa gaaccggcgg gcagttgtcg tcaatcttca gcggatacag catgaccagg 1437901 cgaagcggat tgttgacttt ttaagcggaa ccgtttatgc cattggcggc gatattcaaa 1437961 gaatcggctc agatattttc ctctgcacgc ctgacaacgt agatgtatca ggcacaattt 1438021 ctgagctcat atctgaagac gaacatcaga ggtggtaaag cgagatgatc ctttatcaag 1438081 ttttttcggt tttaagctta ttaatcacaa tatactcatt tgccctgatc atatatattt 1438141 ttatgtcatg ggtgccgagt acgagggaaa cagcagtcgg gcgttttttg gcttcgattt 1438201 gtgaaccata tctcgaacca ttcagaaaaa tcatccctcc gattgcaatg ctggatattt 1438261 caccaatcgt agcaatactt gtgcttcggt ttgcgacaac cggcttgtgg ggactttatc 1438321 gcatgattgc gttttaatgt gacagtttga taggggcttg gcagcagcca agcctcttta 1438381 catagaaggg aaagacgatg agcgatatat atcagcactt cagaaaagac gagcgggcct 1438441 ttattgatca agcgctcgaa tggaaaagaa ttgtccagga gcagtaccgg atgaagctga 1438501 ccgacttttt agatccccga gagcaggtca tcctctctgc tgttacggga caggcagatg 1438561 tcgggcttgc cttttccggc ggctatgaca gagcggagcg gaaacgggcg attctgtttc 1438621 cagagtacat tactccggaa gaatcagatt ttgaactgca ggcgtttaac gtccgttatg 1438681 ctgacaagtt tgtctcagta gatcatcgtt ctctgcttgg tgcattaatg ggcataggat 1438741 taaagcggca aaaattcggt gacatcgtgt tttctgagac agcagtgcaa ttgattgtct 1438801 cagccgatac cgctgatttt gtggctgcac agctgaccca agcaggcaaa gcggcggtca 1438861 gcctagagaa aatcgacttg tcagacctta acattccagc agttgatgtc gaaataagag 1438921 atgacacggt ttcttcttta aggcttgacg ccgtctgcgc ctctatgagc aggcaatccc 1438981 gccagaaatc acagacgctt gtgaaaaacg gccttgtgaa agtgaactgg aaggtggttg 1439041 aagatccttc atacatagtc gcggaagggg acatgctgtc tatcagaggt tttggccggt 1439101 gcagcttaac aaaaatcgaa ggaaaaacca aaaaagacaa atggagagtt acgtttgaac 1439161 gacaaaaata gtcggttttt cagttttttt ctccatctgt gcgaaatttg ttttataatg 1439221 tgaactagat aaccgtactg aaatgtaaaa atggaggtgg catcatgcca ttaacgccaa 1439281 atgatattca caacaagacg tttacaaaaa gttttcgcgg atatgatgaa gatgaagtaa 1439341 atgaattcct agcccaagtc agaaaagatt acgaaattgt tctccgcaag aaaactgagc 1439401 ttgaagcgaa agtcaatgag cttgatgaaa gaatcggaca ctttgccaat attgaggaga 1439461 cattgaataa atcaatttta gttgctcaag aagcggctga agacgtaaaa cgcaattctc 1439521 aaaaagaagc aaagctgatc gttcgggaag cggagaaaaa cgctgatcgc attatcaacg 1439581 aatcgttatc aaaatcaaga aaaattgcaa tggaaattga agagctgaaa aaacagtcta 1439641 aagtgttcag aacacgtttc caaatgctga ttgaagctca gcttgatctt ctgaaaaatg 1439701 acgattggga tcatctcctt gagtatgaag tcgacgctgt atttgaggaa aaggaataaa 1439761 ttctctgatt atcttgacat tttcttagct tgtcgaatat aatacgttca taaattcaga 1439821 tgaaaaaacg gttgaaaggg acagtcatgt ttccttcagg ccttcatagc gacccggaga 1439881 tggtgagagt ccgggatggc cggaatcatg tagatcagcc ctttagtttc cttgctgaac 1439941 tcacagtagg ttaggacgtt catcacgtta cgatgctcaa gaggaaaaag tgtatgcttg 1440001 ctttttctaa aagggtggta ccgcgagata agctttctcg tcccttatgg gatgagaggg 1440061 ctttttttat tttctgaaaa aatgcagtgg aggaatgaaa atggatttta aagacacgct 1440121 cttaatgccg aaaacagatt tcccgatgcg tggaaatttg ccaaaccgtg agcctgacat 1440181 tcaaaaaaaa tgggaggaag aagatatcta ccgtcttgtt caggaacgga cgaaagaccg 1440241 cccgaaattt gttttacatg acggacctcc gtatgcaaac ggcgacatcc atatgggcca 1440301 tgcacttaac aagattttga aagacttcat tgtccgctat aaatcaatga gcggctacaa 1440361 cgcaccgtat gtgccgggct gggatacaca cggattgcca attgaaacag ctctgacaaa 1440421 aaacaaaaag gtcaaccgca aagaaatgtc agtagcggaa ttccgcaaac tatgcgaaga 1440481 gtacgcttgg aagcaaatcg agggacagcg tgagcaattc aaacgtcttg gtgtccgcgg 1440541 tgactgggaa aacccatatg tgacattaaa accggaatac gaagcgcagc aaatccgcgt 1440601 atttggtgaa atggcaaaac gaggctacat ttacaaaggc cttaaaccgg ttaactggtc 1440661 accttcaagt gagtctgctc tggctgaagc cgagatcgaa tatcaagata aacgttcagc 1440721 atctatttac gtcgcttttg gtgtaaaaga cggaaaaggc gttcttgaaa acggcgagcg 1440781 catcatcatt tggacaacaa cgccgtggac aattccggcg aacctcggaa tctcagtgca 1440841 ccctgatctt gagtacagcg tgattgcagt aggtgaagac cgctttgttg tagcaagtgc 1440901 cttagtcgaa aatgttgcat cggcatgcgg atttgatcag tatgaagtga caagaacggt 1440961 caaagggaaa gaccttgaga acattatcgc tgaacacccg ctatatggca gagactctct 1441021 cgttatgctt ggtgaacacg taacaactga tgccggaaca ggctgtgttc atacagcgcc 1441081 tggacatggg gaagatgact ttatcatcgg ccaaaaatac ggtttagatg tgctttgccc 1441141 ggtcgatgaa aaaggtgtaa tgacaagcga agctcctggc tttgaaggca tgttctatga 1441201 tgatgcaaac aaagcgatca cacagcagct tgatgaaaaa ggcgcacttg tgaagcttga 1441261 attcattact cattcttatc cgcatgattg gagaacaaaa aaaccaacca ttttcagagc 1441321 aacagcgcaa tggtttgcgt ctattaaaga tttcagatca gacctgctgg atgccattaa 1441381 agaaaccaaa tgggttcctg aatggggcga gcagcgtttg cacaacatgg ttcgggaccg 1441441 cggagactgg tgtatttcca gacagcgtgc gtggggtgtg ccgattccgg tattttacgc 1441501 tgaaaacgga gaaccggtta ttacagatga aaccattgaa catgtttctg aattgttcag 1441561 acagcatgga tcaaacattt ggtttgaaaa agaagcaaag gatcttcttc cggaaggctt 1441621 tacgcatcct ggcagcccga acggcacatt tacaaaagaa caggatatca tggatgtttg 1441681 gtttgattca ggctcttcac atcaagcagt gcttgaagaa cgtgatgacc tcgttcgccc 1441741 ggctgatcta tacctagagg gatctgacca atatcgcggc tggtttaact cttctctttc 1441801 tacagcagta gccgtaacag ggaaagcgcc gtataaaggt gtgctcagcc atgggttcgc 1441861 actggatgga gaaggacgta agatgagtaa atcaatcggt aacgttgttg ttccggctaa 1441921 agtcatgaaa cagcttggtg ccgacatctt aagattatgg gtatcttcag tggattatca 1441981 ggcggacgtt cgcgtgtctg acgccattct gaagcaggtt gcggaagtat atcgtaaaat 1442041 ccgcaacacg ttccgtttcc ttcacggcaa ccttttcgat tttgatccaa aaacaaatgc 1442101 ggtggctgtc gaagatcttc gcgaagtgga tcagtatatg ctgattaagc tgaacaagct 1442161 gattgataaa gtgaaaaaag cgtatgatga gtacgaattt gcggttgtgt atcacagcat 1442221 tcataatttc tgcacaatcg aattgagctc attctacctt gattttgcaa aagatattgt 1442281 ctacatcgag catgcggatc atccggatag acgcagcatg cagacagtat tctacgaaac 1442341 gcttcttgca ttagtgaagc tttcagcgcc tatccttcca catacggcag acgaattgtg 1442401 gtctcattta acatttgttg aagagcagag cgttcagttg accgatatgc cggaaacaat 1442461 cacggttcca aacagtgaag cgactgaaga aaaatttgac cgctttatgg ctcttcgtga 1442521 tgacgtgtta aaagcattag aaactgcgcg aaatgaaaaa attatcggta aatctttgga 1442581 agcaaacctg aaattgtatc caaacaaaga aaacaaggag ctcttggctt ccataaaaga 1442641 aaacctttct cagctgttta ttgtgtctga actgacaatc agcgaagaaa atgaagcgcc 1442701 gaacgatgcg caaagctttg cgacgggtaa aatcgctgtc gagaaagcgg aaggcgaaat 1442761 gtgtgagaga tctcgtgtga tttcaaaaga tgtaggggca aatccgaaat atcctacact 1442821 ttcattacgc aacgctgaaa tcgttgaaaa atactatcaa aaataatgca aaagagcccg 1442881 gcgtaaaagc cgggcttttt ttgtgccaag agtgacatcc tttagaacga aaggaaaaat 1442941 cttatgggct ttagatcatc attcacaggc aacaataaag atactacgtt aagagcagga 1443001 gttgtgaaga atgaatgatc aactgaccgc aatttatacg gaacttcttc tgatgaaaga 1443061 agaattacag tcgagattat ttgagtattc ttgctttcag gtttctacaa gcccgcaagc 1443121 agcaatcaat caaaaacaaa aagcaactct gatctatcat attaaagaag aacttcaaga 1443181 cgttctcctt gcattgtcca aaatcgaaaa cggcacattc ggatactgtg aagaaactgg 1443241 ggcccccatt cctcttgcaa agctggcagt gctgccgacg gcccgaacag caaacgattt 1443301 tctttattct gtccaatttg agaaaaaaac gcttccgata tggaaatcaa cggatatcga 1443361 atatggtcag gcactgtatg aataacagtg tctgtccggt taatatgcct gatatttctt 1443421 tactccagtg ctttttattg ataaaatgca taatggatta aagtaaccgt aaactggagg 1443481 aacgtttgtg ctgtattata tgattgcact acttattatt gcagccgatc aattgacaaa 1443541 atggctagtt gttaagaaca tggaacttgg ccaaagcatt ccgatcattg atcaggtatt 1443601 ctatatcacc tcccatcgca atacgggtgc tgcatggggg atattagcgg gtcaaatgtg 1443661 gtttttctac ctcataacaa ccgctgttat tattggtatt gtttattaca tacagcgtta 1443721 tacaaaggga caaaggcttc ttggcgttgc cctcggactt atgcttggcg gtgccatcgg 1443781 caactttatc gatcgggctg tcagacagga agttgtggat tttatccatg ttattattgt 1443841 caattacaat tacccgatat ttaacatcgc ggactcttca ctatgtgtcg gcgtaatgct 1443901 tttatttata caaatgctgt tggacagcgg gaaaaagaaa aaggagcaat agcatgaatc 1443961 aaattgatat aaccgcttca gaagaacaaa aaagtgagcg gattgataaa tttttggcat 1444021 cgactgagaa tgattggtca agaacccagg ttcagcaatg ggtaaaagac ggacaggttg 1444081 tcgtgaacgg aagcgcggtg aaagcgaatt ataaaattca gccgggtgat caggtgaccg 1444141 tcactgtacc tgaaccggaa gcgctcgacg tcctggcaga gcctatggat ctggatattt 1444201 attatgagga ccaggatgtg ctggtcgtca acaaacctcg cggaatggtt gttcacccag 1444261 cacccgggca tcttacgggc acacttgtaa acggtcttat ggctcattgc acagaccttt 1444321 ccggaataaa tggtgtgatg cgcccgggta ttgttcacag aatcgataag gacacgtccg 1444381 gtttattaat ggtggcgaaa aatgatatgg cgcacgagtc actcgtaaac caattggtca 1444441 acaaaacggt cacgcggaaa tatacggcgg ttgtccacgg gcttatttct catgatgacg 1444501 gcacaattga cgcgccgatc ggacgggata aaaaagaccg tcaaagcatg actgtgacac 1444561 gtgatggcaa aaacgctgtc actcattttc atgtgcttga gcgttttcag gattttacgt 1444621 tagtggagtg ccagcttgaa acagggagaa cccatcaaat tcgtgttcat atgaaatata 1444681 tcggattccc attagcaggc gatccgaaat acggcccaag aaaaacaatc gactttaatg 1444741 gccaagcgct tcacgcggga gttttaggtt ttgaccatcc acgaacagga gaatatgtcg 1444801 aatttgaagc gccgcttccc gaggatatgg cagaattaat cgaaaacctc agaaaaaacg 1444861 gttgacagag ggtttctttt ctgaaataat aaacgaagct gaatagattc tttaaaacag 1444921 tccagagagg ctgagaagga taacggatag acgggatgcg tgtataggcg cgcaccttgt 1444981 cctaaaaccc ctctatgctc tggcaggagg ggttttttct tctatatgaa ctgtgaggtg 1445041 tcacacattg aatcaaaaag ctgtcattct cgacgaacag gcaattagac gggcgctgac 1445101 caggattgct cacgaaatga tcgaacgcaa taaaggaatg aataactgca ttcttgtcgg 1445161 cattaagaca agagggattt acctggcaaa acgccttgcg gaacgcattg aacagattga 1445221 gggaaatcct gttacagtcg gtgaaattga tattactctt tacagagatg atctttctaa 1445281 aaaaacaagc aacgatgaac cgcttgtaaa aggtgcagat attccggtag atattacaga 1445341 tcaaaaagtc attctcgttg atgatgttct gtataccgga agaacagtca gagcaggaat 1445401 ggatgcgctt gttgatgtag gcagaccttc ctccattcag cttgcagtgc ttgtggacag 1445461 aggacaccgg gagctgccga tccgagcgga ttatatcggg aaaaacatcc cgacatcaaa 1445521 gtctgaaaag gttatggtac agcttgatga ggtagaccaa aacgatctcg tcgccattta 1445581 tgaaaacgaa taatagatca cctttttaag ggcaatccag agaggttgca aagaggtgca 1445641 caacaaaggc ccaaaaagta ttcggcaggt ctttgtatgc ctctttgcgt aaaaaagcaa 1445701 agaggttttt ttatacagtc attgagtcat cctaaaatga aagtcaacaa tcagggggaa 1445761 atcatcatga gtaagaaaaa agtaaattta ggggtcaggg atgtcccgac acctttctct 1445821 tgggtttcat tcagccttca gcatttgttt gccatgtttg gctcaaccat tttggttccg 1445881 aagctcgtcg gaatgagtcc tgctgtggcg ttggtgacaa gcggcatcgg aacactggcg 1445941 taccttctta ttaccaaagg acaaattccg gcgtatctcg gttcatcctt cgcctttatt 1446001 tctccgatca ttctggtaaa agcgaccggc gggccgggag cggcaatggt tggagcgttt 1446061 cttgcagggc tggtgtacgg gctgattgcc ttattgatta ggcagcttgg aacaggatgg 1446121 ctgatgaaga ttctcccgcc tgtagtcgta gggcctgtta ttatcgtcat cgggctggga 1446181 ctggcaagca ctgcagtaaa catggcgatg tatgctgatc cgaacgcgag tgagttggtc 1446241 tacagcttaa agcactttag tgtcgcagga gttacgctgg caattacgat tatttgtgcg 1446301 attttcttac gagggttttt aagcctgatt ccggttctga tcggaatcat cggcggatac 1446361 ctgtttgccc ttactcaagg gattgtcaac ttccagccgg tgcttgacgc gaaatggttt 1446421 gcagtgcctg aatttatcat tccgttcaaa gattattcac cgtcagttac gctcggcatc 1446481 gcagccgcaa tggttcctgt cgcatttgtc acaatgtcag agcatatcgg ccaccaaatg 1446541 gtgctgagca aggttgtcgg acaagacttc attaaaaagc caggtcttca tcgctctatt 1446601 atgggtgaca gtgtggcgac aatcctcgct tccctgatcg gcggccctcc gacaacgact 1446661 tacggagaaa acattggcgt gctggccatc acaagagtat tcagcgtctt tgtcatcggg 1446721 ggcgcggcag tgattgccct ttgcttcggc tttatcggca aaatttcagc gctgatcagt 1446781 tcagtgccgt cagcggtcat gggaggcgtc tccttcctgc tgttcggaat cattgcttca 1446841 agcggcctga gaatgctgat tgacaacaaa attgattatg aaaacaacag aaacctcatt 1446901 attacatcag ttatccttgt catcggtgta ggaggcgctt ttatccaagt gtctcagggc 1446961 ggattccaag tgtcaggaat ggcgcttgcc gcaattgtcg gtgtcatctt aaacctgatt 1447021 cttccgcagg cgaaggaaga gcaggcagac acatctgaac aacatcatat ttaaaacctt 1447081 ttaatgaaag tccagagagg cttggaaggg ttatgaagag aaggaagctt caatgctgcc 1447141 ctctatttaa ccataccccg agtctatctt agaccggggt tttttttcag ccttaagttg 1447201 aaaagagagg ggaaagaaca tgaagcattt aacgacgatg agtgaactta gcactgagga 1447261 aatcaaagat ttgcttcaaa cagcacaaga gctcaaaagc ggaaaaacag acaatcagct 1447321 tacaggaaag tttgcagcaa acctgttttt cgaaccgagc acgagaacgc ggttcagctt 1447381 tgaggtcgca gaaaaaaagc tgggcatgaa tgtgcttaac cttgatggaa caagcacaag 1447441 cgtgcaaaaa ggcgaaacct tatatgacac gatccggacg cttgaatcaa tcggtgtgga 1447501 cgtctgcgtc atcaggcaca gtgaggatga gtattatgaa gagcttgtca gccaggtgaa 1447561 cattccgatt ctgaatgcgg gagacgggtg cggccagcat ccaacacaat cactgcttga 1447621 tttaatgacg atttatgaag agttcaatac gtttaaaggg cttaccgtct ccattcacgg 1447681 cgacatcaag catagcagag tggcaaggtc aaatgcggaa gtgttgacaa gattgggtgc 1447741 ccgggtccta ttttccggcc cttcggaatg gcaggatgaa gaaaatacat tcggcacgta 1447801 tgtctcaatg gatgaagcag ttgagtcttc cgatgttgtc atgctgctgc gcattcaaaa 1447861 tgaacgacat cagtccgctg tcagtcagga aggctattta aacaaatacg gcttgaccgt 1447921 agaacgggct gagcgtatga agcggcatgc gatcatcatg catcctgctc cggtaaacag 1447981 aggagtggag attgatgaca gcttagtaga aagcgaaaaa tcaagaatct tcaagcaaat 1448041 gaaaaatggc gtatttatca gaatggcagt gatacagcgt gccttacaaa ccaatgtgaa 1448101 aagaggagaa gcagcgtatg tcatatctca ttaaaaacgg ctggatacta aacgaaaatg 1448161 gtgaaaaaac acaagcggat atccgagtga ctggagaaac catcaccgca atcggcaagc 1448221 ttgatgcaac ggataatgaa acggtaattg atgcaaaagg tttgctcgtt tcacctgggt 1448281 ttgttgatct ccacgtgcat ttcagagagc cgggcggaga gaaaaaagaa actattgaaa 1448341 ccggggcaaa agcagcggcg cgcggcggct atactacagt agcagcaatg ccgaatacgc 1448401 ggccggttcc tgatacaaag gagcagatgg aatgggtgca aaacagaatt aaagaaacat 1448461 catgcgtaag agttcttcca tatgcatcca ttacgatcag acaaatcggc gatgaaatga 1448521 caaactttga agcgttaaaa gaagccgggg catttgcttt tacagatgac ggcgttggta 1448581 tacagacagc aggaatgatg tatgaagcga tgaaacgggc agccgcaatt gacaaagcga 1448641 ttgttgcaca ttgcgaggac aactccttaa tttacggagg gagcgtacat gaggggacat 1448701 tctccaaagc gaacgggcta aacggcattc cttctgtgtg tgaatcggtt catattgctc 1448761 gcgatgtgct gctggctgag gcggcaaact gccattatca tgtatgccat atcagcacaa 1448821 aagaatctgt cagagttgta cgcgatgcga aaaaagcggg aatcagagtg acagcagaag 1448881 tatcgccgca tcatttgctg ctttgtgatg aggacatccc ggggctggac acaaactata 1448941 aaatgaatcc tccgctccgc agcccagaag acagagctgc tttaattgaa ggtcttttag 1449001 acggaacaat tgattttatc gcaacagacc atgcaccgca tacggaagaa gagaagaaca 1449061 cagaaatgaa gctggcgcca ttcggaattg tcggcttaga aacagcattc ccgcttcttt 1449121 acacacactt tgtcaaaaat ggcagctggt cactgaagca gctgattgac tacatgacaa 1449181 tcaagccatg cgaagcgttc ggtctcccat atggaacatt acaaacgggg caagctgcgg 1449241 acattacgtt aatcgattta gaaaaagaag cagttataga caaagagaca tttttatcaa 1449301 aaggaaaaaa tacaccattc aacggcatca gttgcaccgg ctggccggtc gctacaattg 1449361 cggcagggaa gcttgcttat gaagagggga gacttgtcaa atgaagagac gattagtact 1449421 ggaaaacgga gcggtattcg agggagaagc tttcggaagc ttagaacaca acatgggaga 1449481 agtcgttttt aatactggga tgacaggcta tcaggaaatt ttatctgatc cttcttactg 1449541 cggacagatc gtaacattaa catacccgct tatcggaaat tacggcatta accgtgatga 1449601 ttttgaatcc attacccctt ttgtcaaagg gctgatcatc aaagaattat gtgagctgcc 1449661 ttccaactgg cgttcagcat acaccttaga cgagtattta aaaatgaaaa acattcccgg 1449721 actccaggga attgatacaa ggaagctgac aagaatgatc cgcacggcag gcgcgctaaa 1449781 aggaacattc gcttcatctg atgaagatat cgaagcagtg ctgaaaagac tgaacgaaac 1449841 ggaattgcca agaaatcaag tatcccaagt atcagcaaaa acagcatatc cgagcccggg 1449901 aagaggcaaa cgcattgtct tggttgactt cggcatgaaa cacgggattc taagagagct 1449961 gaacaaacgg aaatgtgacg tcatcgttgt gccttacaac attacagcgg aagaggtgct 1450021 tcagctgaaa ccggacggta tcatgctttc taacggacct ggagacccga aggatgtgcc 1450081 tgaagcgatt gaaatgatta aaggtgttct tggaaaagtg ccattattcg gaatatgtct 1450141 cggccaccaa ttattcgcgc tggcgtgcgg ggcgaatact gaaaaaatga aattcggcca 1450201 caggggctca aaccacccgg taaaagagct ggctacagga aaagttgcct taacatctca 1450261 aaaccatgga tatacagttt cgtctatcag taaaacagaa ctggaagtga cgcatatcgc 1450321 aattaacgac gatacgattg aagggctgaa gcataaaaca ttgccggcat ttacggttca 1450381 atatcatccc gaagcctcac ctggtcctga ggatgccaac catctatttg acagattcat 1450441 cgaaatgatc gaaacaacag agaaagaagg ggaagcggta tgccaaaacg cgtagacatt 1450501 aacaaaattt tagtaatcgg atctggaccg atcatcatcg gccaagcagc agaatttgac 1450561 tatgcgggaa cacaagcctg tcttgctttg aaagaagaag gctatgaagt catccttgtc 1450621 aactcaaacc ctgcaacgat catgacagat acagaaatgg ctgaccgggt ttacatcgaa 1450681 ccgctcacac ctgaattcct gacacgaatc atcagaaaag agcgcccgga tgccattctt 1450741 cctacactcg gaggccaaac cggtttgaat cttgcggttg agctttctga aagaggcgtt 1450801 ttggcagaat gcggcgtcga agtgcttggc acgaaactgt ctgcgattca gcaagctgaa 1450861 gaccgtgact tgttcagaac attaatgaat gaactgaatg aaccggtgcc tgaaagtgag 1450921 attatccact cccttgaaga agcagaaaaa ttcgtcagtc aaattggatt ccctgtcatt 1450981 gtccgcccgg catatacatt aggcggaaca ggcggaggca tctgctcgaa tgaaacagag 1451041 ctaaaagaaa tcgttgagaa cggcttgaaa ttaagcccgg tacaccaatg tctgcttgaa 1451101 aaaagcatcg ccggctataa agaaatcgag tatgaagtca tgagagacag ccaggatcac 1451161 gccattgtcg tttgtaacat ggaaaacatt gatccagttg gaatccatac tggagacagt 1451221 attgttgtcg cgccgagcca aacgctcagc gatcgcgaat atcagctctt gcggaatgta 1451281 tcgttaaaac tgattcgcgc gcttgggatc gaaggcggat gtaatgtcca gctcgcctta 1451341 gatccagaca gcttccaata ttacattatt gaagtaaatc cgcgtgtcag ccgttcatct 1451401 gcccttgcat caaaagcaac ggggtacccg attgcaaagc tcgctgctaa aattgcagtc 1451461 ggactttcat tagatgaaat gatgaacccg gtgacaggaa aaacatatgc agcatttgaa 1451521 cctgctcttg actatgtcgt atccaaaatt ccgcgctggc cgtttgataa gtttgaatca 1451581 gcaaacagaa agcttggcac gcaaatgaaa gcgacaggtg aggtcatggc aatcggccgc 1451641 acgcttgaag agtcattgct gaaggcagtg cgatcactgg aagcggatgt gtatcatctt 1451701 gaattgaagg acgccgctga catttcagat gagcttcttg aaaagcgaat taaaaaggcc 1451761 ggtgatgaac gcttattcta cttagctgaa gcgtacagaa gaggctacac ggtagaagac 1451821 ctccatgaat tttccgctat cgatgtcttc ttcttgcata agctgttcgg aatcgtacag 1451881 tttgaaaaag aattgaaggc caatgcgggc gatacagatg tgctgagacg ggcaaaagaa 1451941 ctcggcttct ctgatcagta catcagccgt gaatggaaaa tgaaagaatc tgagctttac 1452001 agcttgagaa aacaagcggg gattgcgccg gtattcaaaa tggtagatac atgcgcggcg 1452061 gaatttgagt cagaaacgcc atacttctat agcacatatg aagaagaaaa tgaatctgtc 1452121 gttacagata agaaaagtgt gatggtgctt ggttcgggtc cgattcgaat cggtcagggt 1452181 gtcgagttcg actatgcgac ggttcactct gtatgggcaa ttaaacaagc aggctatgaa 1452241 gccattattg tcaacaacaa cccggaaacc gtttcaacag acttcagcat ctcagacaag 1452301 ctgtattttg aaccgcttac gattgaagat gtcatgcaca tcattgacct cgaacagcca 1452361 atgggcgttg tcgtacaatt tggcggacaa actgcgatta accttgctga cgagctttct 1452421 gcacgcggag tgaaaatcct tggaacttca ttagaagatt tagaccgtgc cgaagaccgg 1452481 gataaatttg aacaagcgct tggagaactt ggtgttcctc agccgcttgg caaaacagcg 1452541 acatcagtta atcaggcggt aagcatcgca agtgatatcg gttatccggt actggtacgc 1452601 ccttcctatg tacttggcgg ccgggcgatg gagattgttt accatgaaga ggaactgctt 1452661 cattacatga aaaatgcagt caaaatcaat ccacagcacc ctgtattaat tgatagatac 1452721 ttgaccggaa aagaaattga agtcgatgca gtatccgacg gtgaaacagt cgtcattccg 1452781 ggaattatgg agcacattga acgtgcgggc gttcactccg gagactcaat cgctgtttat 1452841 ccgcctcagt ctctcacaga ggacattaag aaaaaaattg aacaatacac gatcgcattg 1452901 gctaaagggc tgaatattgt cggtttgctc aatattcaat tcgtcttgtc gcaaggcgag 1452961 gtgtacgtgc tagaagtgaa tccgagatca agcagaaccg taccgttttt aagcaaaatt 1453021 acgggtatcc caatggcgaa tctcgcaaca aaaatcattc ttggtcaaaa gctggctgcg 1453081 tttggctata cagagggcct tcagcctgaa cagcaaggtg tatttgtaaa agcgccggtc 1453141 ttctcctttg ccaagctgag aagagtggat attacgttag ggcctgaaat gaaatcaaca 1453201 ggtgaagtca tggggaaaga ttcgacactt gaaaaggcgc tctacaaagc cttgatcgct 1453261 tcaggtattc aaatcccgaa ctacggttcc gtgcttttaa cagtagctga taaggacaaa 1453321 gaagaagggc ttgccattgc taagcggttc cacgcgatcg gctacaacat tttagcgacg 1453381 gaaggaacgg caggctacct gaaagaagct tccattccag cgaaggtcgt cggaaaaatc 1453441 ggtcaggatg gcccgaactt gcttgatgtc atcagaaacg gagaagcgca gtttgtcatc 1453501 aatacgctga caaaaggaaa gcagccggca agagacggtt ttagaatcag acgtgaatca 1453561 gtagaaaatg gtgttgcctg cctaacatct ttagatacgg cagaggcgat attgcgagtg 1453621 ctggaaagca tgacattccg tgctgatcaa atgccggcag tcaacacaaa tcaggaggcg 1453681 gcagtcacta tatgaaaaaa gcgtatttga cagtatgttc taaccagcaa attgcagacc 1453741 gggtgtttca aatggttctg aaaggggagc ttgtccaagg gtttacaacc cctggacagt 1453801 tccttcatct taaagtgagc gaagcggtta cgcctctttt gagaaggccg atcagcatcg 1453861 cagacgtcaa ctttgaaaaa aatgaagtca ccatcattta tcgggtagat ggggaaggga 1453921 caagactctt gtcactgaag cagcagggag aacttgtgga tgtcctcggg cctttgggaa 1453981 atggctttcc tgttaatgaa gttcaacccg gaaagacggc tttgctggta ggaggcggag 1454041 taggtgtgcc gcctctccaa gagctgtcga aacgcttgat tgaaaaaggg gtaaatgtca 1454101 tccacgtttt aggattccaa tcggcaaagg atgtttttta cgaggaagaa tgccggcagt 1454161 acggagacac gtatgtggca acagctgacg gaagctacgg ggaaaccgga tttgtcacag 1454221 atgtgattaa acggaaaaag ctagagtttg atatcctcct cagctgcggg ccgacaccga 1454281 tgctcaaggc gttaaaacag gaatatgccc ataaagaagt atatctgtcc atggaggaac 1454341 gaatgggctg cggaatcggc gcatgcttcg cgtgtgtgtg ccatacaaac gaaagtgaga 1454401 catcctatgt aaaagtatgt ctcgacgggc ctgtatttaa agctcaggag gtggcgctgt 1454461 aatgctagag gtgaaattgc cgggacttga tttgaaaaac ccaatcattc ctgcatcagg 1454521 ctgcttcggt tttggaaaag aattttcacg tttttatgat ttgtcttgtc ttggagctat 1454581 catgattaag gctacgacaa aggagccgcg ctttgggaat ccgacgccgc gggtagctga 1454641 gactggtgct ggaatgctca atgcgatcgg tctccaaaat ccggggctgg atagtgtgtt 1454701 gcatcatgag ctgccgtggc ttgagcagtt tgatacaccg atcattgcca atgtcgcagg 1454761 ttctcaagtc gatgattatg ttgaagtcgc agaacatatc agcaaagcgc ctaatgttca 1454821 tgctcttgaa ttgaatattt cctgcccgaa tgtgaaaaca ggcggaatcg cttttggcac 1454881 gaatcctgaa atggctgccg atttgacaaa agcggtgaaa gaggtttcgg atgtacccgt 1454941 ttatgtgaag ctatccccga acgtggctaa tatcacagaa attgcattag cgatcgagga 1455001 agcgggagcg gacggtctta cgatgatcaa cacactaatc ggcatgagac tcgatttaaa 1455061 aaccggcaaa ccgatattag cgaataaaac agggggactt tcgggccctg ctgtgaagcc 1455121 ggttgccatt cgcatggtgt atgaagtcag ccagatggtc aacatcccga ttatcggaat 1455181 gggaggcgtg caaacggctg aagatgccct ggaatttctt ctcgcgggag caagcgcagt 1455241 cgctgtcgga acagcaaact ttgtgaatcc ttttgcatgt ccagagatta ttgaacagct 1455301 cccatctgtt ttgctccaat acggctatca atcaattgaa gaatgcatcg gaaggagctg 1455361 gaatcatgaa aaacaacctg cccatcatcg cgcttgattt tgcgtcagct gaagaaacac 1455421 ttgcgttctt agcgcctttt cagcaagaac cgttatttgt aaaggttggg atggagcttt 1455481 tttatcaaga agggccatct atcgtgaaac aactaaaaga aagaaactgc gagctatttt 1455541 tagatctaaa gcttcatgac atcccgacta ctgtaaacaa agcgatgaag cgccttgcca 1455601 gtcttggagt agacctcgtc aatgttcatg ctgccggggg caaaaaaatg atgcaggcag 1455661 ctctcgaagg cttagaagaa ggtacgccgg ctggaaaaaa acgtccgtca cttatcgcgg 1455721 taacccagct gacaagcaca tctgaacaaa tcatgaaaga tgaactgctg atcgaaaagt 1455781 ctctgattga tacggttgtg cactacagca aacaggcgga agaaagcgga ctggatggag 1455841 tggtctgctc tgttcatgaa gcaaaagcca tttaccaagc ggtgtcgcct tcatttctga 1455901 ctgtcactcc ggggatcaga atgtcagagg acgctgcgaa tgaccaagtt cgcgtagcga 1455961 cgcctgccat tgcaagagag aaaggttcat cagcgattgt agtaggacgc tcgattacaa 1456021 aagcggaaga cccggtaaaa gcctataagg ctgtcagact tgaatgggag ggaatcaaat 1456081 cttgaaacaa atcatcgcaa aacatctatt agacatccaa gctgtatttt tacgcccgaa 1456141 cgagccgttc acatgggcaa gcggcatttt atcaccgatc tactgtgaca accgccttac 1456201 gctatctttc ccagaggtca gaaacgatgt tgcttcaggt atcagcaagc ttgttaaaga 1456261 gcattttcct gaagctgaaa tgattgcggg aacagcaact gccggtattc ctcatgctgc 1456321 tcttgcggcg gaccatttga atcttccgat gtgttatgtg aggagcaagc cgaaggcgca 1456381 cggaaaaggc aatcagattg agggagctgt gcaagaaggg caaaaaacag tcgtcattga 1456441 agacttaatt tccacaggag gcagcgtgct tgaagcttgt gcagctttac aagcggccgg 1456501 ctgtgaagtg cttggtgtcg tctcaatctt tacgtacgga cttcctaaag cggaggaagc 1456561 cttcgcaaag gcagaactgc catactactc attaaccgat tatgatacgc tcacagaggt 1456621 cgcgcttgaa aacggaaata ttcattcaga tgatctaaaa aagctgcaaa catggaaacg 1456681 aaatcccgag tcaaaagatt ggtttaaaaa ataaaaaata aattcaaatg atgtaaagag 1456741 gcttcaaagc cttgctgtac ttgaaaacag gctgtgaggc ctgttttttt attaatccta 1456801 taaaaaaagt cgggttgact tatgttagaa ttgtgctaaa atttactaca aatctaaaaa 1456861 cttatcaaga gcggctgagg gactggacct atgaagcccg gcaacctgca tagtttgtaa 1456921 ggtgctactt ccagcaaaat gaattccatt ttgaaagata agggctgcat gctgttcctg 1456981 tctttctttc cgccggattg aaagtttttt attttaagag gtaaaaaggc tatctgtata 1457041 tcagcagccg cgaatcacat tacatgggaa aagacaaccg gcagaaagct actgtttgtt 1457101 tgtctccgaa aggaggaaag aagaaatgtt aacgtatgat aattgggaag aaccaacgat 1457161 tacatttccg gaagacgatc cttataaagg agcgctgtca gttttaaaat gggcatacgg 1457221 ccattacggc gatcagcttg tttatgcctg cagtttcgga attgagggaa tcgttctgat 1457281 tgacttaatt tataaagtga aaaaagacgc agagattgtg tttcttgata caggacttca 1457341 ttttaaagaa acctatgaaa caattgaacg agtgaaagag cgttatccgg gtcttaatat 1457401 catcctgaaa aaaccagatc tcacccttga ggaacaagcc gaagaacatg gtgacaaact 1457461 atgggaaaga gagccgaatc agtgctgcta tcttagaaag gtcgttcctt taagagaggc 1457521 gctttcagga catccagcct ggctttccgg cctgcgccgt gatcaagggc caagccgtgc 1457581 caatacgaat ttcttaaaca aagatgaaaa attcaagtca gtaaaagttt gcccgcttat 1457641 ccattggact tggaaagaca tttggagata tacatcccgg aatgaactgg actacaatcc 1457701 gcttcatgac caaggctatc caagtattgg ctgtgcgcct tgcacttctc ccgcttttac 1457761 agcagaagat ttgcgctcag gcagatggaa tggtatggcg aaaacagaat gcggactgca 1457821 tgaataagga gctgcaaaat ggaattagcc gctattttat ttagcttgtt tttcgcgatg 1457881 aatattggtg caagcggcgc tgcagcttcg atgggggttg cttacggctc cggagccatc 1457941 aaaaagaaaa cttacgcttt gatcctatgc gcagtcggtg tctttgccgg ggcggtcatt 1458001 ggcggaggcg aggttgtaaa aacaatcagc tccggcatta ttcctgagca gacgattaca 1458061 ctgacgattg tttgcatcat tattggagct gctgccctgt cgctctttac tgctaatctg 1458121 ctcggcattc ctttgtcgac aagtgaagta acagtcggcg cggttgtcgg cgtgggagtg 1458181 gcttataaag tattgtttgt gaacaatctt ctgatcattg tgtcattttg ggtttttgtc 1458241 ccgctgttcg ctttcggctt cacctatttc gtatctaagc tgtttcgtta ttttaagatt 1458301 gaagtaaaat cttctaaaaa gcaaaaaatc ctcggcattg ttttgttagt tgccggattt 1458361 ttcgaagcat tctctgccgg catgaataac gtggcgaatg ctgttggccc gttagtagct 1458421 gccggtgtgc ttgatgtcgg aaaaggaacc ttgtatggag gagcttttgt tgctcttggc 1458481 gcactgttat taggccggcg agtgctagaa acaaacggga agaaaattac gaggttctcc 1458541 aaaggggaag gcattctctt atccggtaca ggagcgggac tggtgatcat cagttctgta 1458601 tttgggatgc cggtgccctt ggcgcaagtc acgtcatcgt ctattatcgg aataggcatg 1458661 gcgaaaaacg gtccgaacgt gttccataaa caagttgttc aaacgatgct gaaggtatgg 1458721 atcgtatcgc cgtttttatc tttatcgatt tcttatctgc ttgtatcctt gtttttaaaa 1458781 gcagattatt attcgatctt tatcatggta agtgtgcttt tagcggcggg cggtgccatc 1458841 agcctgacaa aggccattcg taaagagaga cgctcagtcc acgaacaagg cgggggaatc 1458901 tgatcattaa tctgagtaat tttataagtt aactaggagg agatggatat tatgagctta 1458961 gcaccacacg gaggaacatt agtaaacaga gtagatgaat catatgatgt gagcggcatt 1459021 caaaaagaaa ttgaacttga tttaatttct ttcgcggatt tggaattgat cggtatcggt 1459081 gcatacagcc cgattgaagg tttctttaat gaaaaagatt acgtatcagt ggtcgaaaac 1459141 atgcgtcttt cttccggcgt tgtctggtct cttccaatca cgcttccggt cgatgcgcaa 1459201 aaagcagcgg aactgtcact tggtgaaacg gtaaagttaa cgtatgaagg agaaacttac 1459261 ggcgttatcc aaatcgaaga cctgtacgtg cctgacaaac aaaaagaagc tgtcaatgtg 1459321 tacaaaacag atgaacagga gcatcctggt gttaaaaagc tgttcagccg cggcaataca 1459381 tatgtcggcg gaccgattac gttgattaaa aaagcttcaa aacagttccc tgaatttaca 1459441 tttgaaccgt cagaaacgag acgccagttt gcggaaaaag gctgggaaac cattgtcggt 1459501 ttccaaacaa gaaaccctgt tcacagagcg catgaataca ttcaaaaaac ggctcttgaa 1459561 acagtagacg gcttgttctt gaatccgtta gtaggtgaaa caaaatctga tgacattcca 1459621 gctgatgtac ggatggaaag ctaccaagtg cttcttgatc attattaccc gaaagatcgt 1459681 gttttccttg gtgtcttttt agcggcgatg cgttatgcag gcccgagaga agcaattttc 1459741 cacgcgcttg tcagaaagaa ctacggctgc acacatttca tcgtcggccg tgatcatgca 1459801 ggtgtaggcg actattacgg aacatacgaa gcacaggaac tgtttgacac atttaaacct 1459861 gaagaactcg gaattacacc gctgaaattt gagcacagct tcttctgtaa aaaatgcgga 1459921 aatatgggaa cagcaaaaac ttgccctcat ggcagagagc atcacgtcat tttatcaggc 1459981 actaaggtaa gaggtatgct gagagacggt gtgctgccgc ctgctgaatt cagtcgaaaa 1460041 gaagtagtag aagtgttaat caaagggatg aagaaaaaag aagaagtagg cgtatcttaa 1460101 ggaggactgg cagtgacaaa tcgcgatatt gtatggcatg aagcctctat cacaaaagaa 1460161 gagtatcagc aaaaaaacaa gcataaaagc tccattctct ggctgacagg gttaagcggc 1460221 tcaggcaaat caaccattgc caacgccgct gcgagagaat tgtttgagca aggctaccaa 1460281 gtcattgtgc tggacgggga taatatccgt cacggcctaa atagggatct tggtttttct 1460341 gatgaagacc gaaaagaaaa catccgccgg atcggagagg tggcgaagct ttttgttcag 1460401 cagggaacca ttgtgattac tgcttttatc tctcctttcc gcgaggacag acaacaggtt 1460461 cgcgagcttg tggaagcggg cgaatttaat gaagtctaca ttaaatgcga ccttgatatt 1460521 tgtgaacaaa gagatccgaa agggctttac aaaaaagcaa gaaacggcga gattccgttc 1460581 tttacaggaa ttgattctcc ttatgaagaa ccggaagctc cagagctcgt tcttgattca 1460641 ggacagcatg accgtgaagc gtgtaaaaat cagctgatcg agtttgttaa acaaaaattg 1460701 agctgaatat gatctgctgc gttcttctca gatgccggaa tgcaagcgag aacatcatca 1460761 cagcgaatct tctggaagaa ctcgaataga tcgggggaaa tacgatgggg aaagtatata 1460821 ttgtaggagc gggtcccggt gaccctgatc tgctgacaat taaagcgctg aaagccattg 1460881 aaaaagctga tgtcatctta tatgacagat tagtaaataa agagatttta caatatgcca 1460941 aagagcaagc agacctgatc tactgcggga agcttccgga ttttcatacg atgaagcagg 1461001 aaaccatcaa tcgatttctt gtgaagtatg cgcaaaaagg gaaaatggtt gtcagactga 1461061 aaggcggaga cccttttgtg ttcgggagag gaggggaaga agcggaatgc ctctctgaaa 1461121 atggaattcc gtttgaaatc attcccggca ttacgtctgg aatcgcggca gccgcttatg 1461181 ccgggattcc tgttacccat cgggatgcgg gctctaacgt cgcttttgta acgggtcact 1461241 ataaaaaaga agaagatttt gaggaaaagt ggaaagcgct ggctacagga attgatacac 1461301 ttgtcatcta tatgggtatc aaaaacgtgc agcagattga aagaaaactc cttgaaaatg 1461361 gccgggacgg ttctacgcca gcagccttta ttcattgggg gacaacggac aagcaaaaat 1461421 ctgttttttg tacagttgac accctttcag aaacggtgat aaaagaaaac attacaaatc 1461481 cgagtttaat tgtcattgga aatgttgtaa attatcacta taagctggaa tggtttgaat 1461541 ctgaactaaa aaaacaagat ttaagcgagg cgttgtaaaa atgaaacaag caattttata 1461601 tgtcggccac ggcagccggg tcaaaaaagc gcagcaagaa gccgcagcct ttttggaagg 1461661 atgcaaggcc cacatctctg tgccagtaca agaaatcagc tttttagagc ttcaggagcc 1461721 gacaattgag acaggatttg aagcatgtgt gaagcaaggt gccactcata tcgcagtggt 1461781 gcctctgctt cttttaacag ctgcgcatgc aaaacatgat attccggaag aaattgtccg 1461841 tgttgcatct cgatatccat cagtccgtat ttcatacgga aagccgatcg ggattgacga 1461901 agaagtagtc aaggctgtat atcaccgaat gaaagacata ggtgttccgt atgaaaatgc 1461961 cagagtggtg ctcatcggaa ggggaagttc agatccagac gtcaaaagag acgtaaccgg 1462021 aattgctaat cttcttcagg aaatggttcc agtgaaggaa gtcattccgt gctttttgac 1462081 agcatgcggc cctaattaca aagaggtttt ttcagaactt gaaaaagatg acggcataac 1462141 aacctttatc gttccatatt tgctttttac gggtatgctg atgaatgaaa tcgaacgaga 1462201 ggttcagaaa ttaaaagccc ataatccgaa cgtctacctc tcttcctata tcggttttca 1462261 tcctcatgtg aaaaacgcat ttttgaaccg tgtgagagaa actgcggcaa attctgaggg 1462321 acaatttgat tttgatggag gttcatatgc ttccgctgca cattagcctg gaaaagaaga 1462381 aggttgtgat tgcggggggc ggaagcatcg ctctcagaag gctgaaaacg gtgatttctg 1462441 agggagctga tataacgctt gtcagtccgg atgtggaacc ggaaatcaag caaatggcag 1462501 aagagcggcg tatcaaatgg gaaaaacgga caattgaaaa agaagattat ctcaatgctt 1462561 tcttcattat tgctgcgacg gataatgcgg cagtgaacaa agaaattgcc caatccgctt 1462621 cgccttttca gcttgtcaat tgtgtcagtg acgctgagct tggcaatgta tatatgccga 1462681 aaatcgtaaa aagagggcat gtcactgtgt ctgtttctac aagcggagcc agtccaaagc 1462741 acacgaaaga gcttgctgaa aacgtggata agctgattga cggcgatttt gttgctgaag 1462801 tgaacaggct ttatcagatg agaagaaaga aataagccag agcatacaaa tgctctggct 1462861 tttctttatg cggctcagct ttttttgagc ttgatgacag tatcagcatc aggcgtgaca 1462921 aagacggtat gctggctgtc ataagtgacg aaaccgggtt tcgcgccgtt tggttttttg 1462981 acatgcctga tttttgtata atctacaggc actgaacttg aatctttagc ttttgaaaaa 1463041 taagctgcaa ttgtcgcggc ttccatgatt gtttgctcat caggttcgct gcttctgatc 1463101 acaacgtggg agccgggaat gtccttcgtg tgaagccaga tatcgtctct ggccgccact 1463161 cttgtcgtta aatattcatt ttgacgattg ttcttaccca ctaaaattgt cagccctgag 1463221 gtggattcat atgtttctaa caccggattg tgcggttttt gctttttctg gcctttttgc 1463281 tgcttagggc gtaaatattt gccctcaaca agctcttccc tgatttcgct gatatcccgg 1463341 ggagaagcgg acgaaagctg ctgaatcagc tgatcaaaat attcgatctc ttcctgtgcc 1463401 agcctgattt gctcctcgac aactgcgacc gaatttttcg ctttctgata cttcgtgaaa 1463461 taggcctgtg cgttttcaga aggcgttttg ttcgggttta aaggaatcgt gattgtcggg 1463521 ctttcttcat cataataatt gatgacctca gcctgtttat cacctttttt cagcatatat 1463581 aaattagcgg ttaaaagctc tccgtaaagc tgaaattcct tcgcgttttc cgaatactcc 1463641 agggttttct ctaatttttt gattttgttg gcattcttct tccgttcgtt cacaacaaaa 1463701 cgctcaagat cctgagcctg ttgcttaacc cggtctcgtt cagcttttcc gaaataaaaa 1463761 cggtcgagca gttcgcttaa tgaatcaaaa cggcgcgctt cgccctttag atgagtcagc 1463821 tccagcagat aaaaatattc ctttccgttt acagtcgtaa tgttgggaat gaaacggtgc 1463881 tctttcactt cggcaaacag tgccagcaac gcttttggca gtgtgacttt gttggcaagg 1463941 cctgctctgt gaaccgcttc tttggcgaaa agcggagaca cgcctgaaaa gtggtcgaca 1464001 atttgtttat caagccttcc ttcttgaaag ctgaggtgac gcaaaatatc atcttctgac 1464061 gcctcaagag gcgatatttt gtcctgagca ggcggaagct tataatcttg gccgggcagt 1464121 actgtacggt agctgttcat tgacggtgat aaatgcttaa gtccgtcgat aatcacattt 1464181 tctgctgcgt cagtcaaaat gatattgctg tggcggccca taatttctac ataaagcttt 1464241 cgtacggttt catcgccaat ttcgtttcgg cttttgatat gaaaaatcat aatgcggtct 1464301 aagcccgctt gttcaatttt ctcaatgaat ccgccttcga tatgctttct cagcaacatg 1464361 caaaacattg gcggttcgct tggattttca taagcttgtg ccgtgatatg cacccgtgaa 1464421 tagctcggat gtgccgataa taatagtttt tggttttttc ccttggcacg gatgtggaaa 1464481 atcacatcgt gcttatatgg ctgatggatt tttgtaattc gtccgcccat tattttctcg 1464541 ttaagttcgt gtgtcattcc gtatgtaaac atgccatcaa acgacatatg caatacaccc 1464601 tctcattctt cctgcattcg ataattatag catgaaatgg gacgagtcag aataagcatg 1464661 cttatagagt gatatctcta taagagagca ggggagtgga cgagcggaat gaagtttcat 1464721 gaaatgggac aaacagattt actagaggca accaatacgt ccatgaaaca aggattaaca 1464781 gaaaaagagg taaaaaaacg ccttgacaag catggaccaa acgagctgca agaagggaaa 1464841 aaaacttcag cgcttctctt gtttttcgcg cagttcaaag attttatggt gcttgtgctt 1464901 ctggcggcaa cgttaatctc aggatttctt ggtgaatatg tagatgcggt tgcgattatt 1464961 gcgattgtgt ttgtgaatgg catactcggt ttctttcaag aaaggcgtgc tgagcaatct 1465021 cttcaggctt taaaagagct ttcaacaccg cacgtcatgg cactcaggga aggaagctgg 1465081 acaaagattc cttctaagga actggtgccg ggtgatattg tgaaatttac gagcggggac 1465141 agaattggcg cagacgttcg aattgttgaa gcgagaagcc ttgaaataga agaatcagcg 1465201 ctaaccgggg aatcaatccc ggttgtgaag catgctgata aattgaaaaa accggatgtt 1465261 tcactcggcg atattaccaa tatggcattt atgggtacga ttgtgacccg cggcagcggt 1465321 gtcggggttg tcgtcgggac aggaatgaat acggctatgg ggaaaattgc cgacatgctt 1465381 gaatcggcag ggacattgtc aaccccgctg caaagaagac tggagcagct cgggaagatt 1465441 ttgattgttg ttgcattgct tctgaccgta cttgtcgttg ctgtcggtgt tattcagggt 1465501 catgatctgt acagtatgtt tttagcaggt gtctcgttag cggtagccgc tattccggag 1465561 gggctgccgg cgattgtgac agtggcgctt tcgcttggtg tacagaggat gattaaacaa 1465621 aaatccattg ttagaaagct tcctgctgtt gaaacgcttg ggtgtgcgtc tatcatttgc 1465681 tcagataaaa cagggacaat gacccaaaac aaaatgacag tgacgcatgt ctggtccgga 1465741 gggaaaacat ggagagtggc aggggccggc tatgaaccga aaggaagctt cacactaaac 1465801 gaaaaagaga tcagtgtcaa tgaacataag ccgcttcagc agatgcttct gttcggagcg 1465861 ctttgtaaca actccaatat tgagaaaaga gacggcgaat atgtgcttga cggagatccg 1465921 acagagggag cgctgctcac cgcggcaaga aaaggcggtt tttcaaagga gtttgttgaa 1465981 tctaattaca gagtgattga agaatttccg tttgattccg cacggaaaat gatgactgtc 1466041 atcgtagaga atcaagacag aaagcgctat atcattacaa aaggtgcgcc ggatgtactc 1466101 atgcagcgat cttcccgtat ttattatgat ggctcagcgg ctcttttttc aaatgaaaga 1466161 aaagcagaaa cagaggcggt attaagacat ttggcatcac aggcgctcag aacgatagcg 1466221 gtcgcctaca ggccgataaa agcaggcgaa acaccgtcaa tggagcaggc ggaaaaagat 1466281 ctgaccatgc ttggcctttc aggtatcatt gatcccccgc ggccggaagt cagacaggcg 1466341 attaaagaat gccgtgaagc gggaattaag accgtcatga ttacaggtga tcatgtagaa 1466401 accgctaaag cgatagcgaa agacttgcgc ctccttccga aaagcggcaa aatcatggac 1466461 ggcaagatgc tgaatgaact ttctcaagaa gagctttctc atgtggtgga ggatgtgtat 1466521 gtatttgccc gcgtttcccc tgaacataaa ctaaaaatcg taaaagccta tcaggagaac 1466581 gggcatattg tggcgatgac gggagacggc gtcaatgatg ctcctgccat taaacaggct 1466641 gatatcggcg tctctatggg cattaccggg acagatgtgg ccaaagaagc atcatctctt 1466701 gttctcgtgg atgataattt tgcgacgatt aaatcagcga taaaagaagg caggaacatc 1466761 tacgaaaata tcaggaagtt tatcagatac ctgttggcgt ctaacgtcgg agaaatcctt 1466821 gtcatgctgt ttgcgatgct gcttgccctt cctttaccgc tggttccgat tcagattttg 1466881 tgggtcaact tggtgacgga cggattgccg gcaatggcgc tcggcatgga tcagccggaa 1466941 ggagacgtca tgaagcgcaa gccccgtcat ccgaaagaag gggtatttgc ccgcaagcta 1467001 ggatggaagg tcgtttccag aggattttta atcggagttg ccactatttt agcgtttatc 1467061 attgtgtacc accgcaatcc ggaaaacttg gcttatgccc agacgatcgc gtttgccaca 1467121 ttggtgctcg ctcagcttat tcacgtgttt gactgccgca gcgaaacttc tgttttctct 1467181 agaaatccgt ttcaaaacct gtatttaatc ggcgcggtat tgtcatccat tttgctgatg 1467241 cttgtagtaa tctactatcc gccgcttcag ccgattttcc atactgtagc catcacgccg 1467301 ggggactgga tgctcgtcat cggtatgtcc gccatcccta cttttttgct ggcggggtca 1467361 cttttaacaa gaaaaaaata aattcatatg atataatctt aggggtaata gcgtgtctat 1467421 tgccctttta ttatgagaac agggaagaat tgggtgtttt aaaatgatac gaagtatgac 1467481 aggcttcggc agtgcaagca aaacacaaga cgatctctct gtaagcgttg aacttaaatc 1467541 tgtgaactac agatttaaag aagtgaacgc tcgtttgcca aggcctttgc tatattttga 1467601 agataagctg aaacagacca ttctgcagca tattcagcgc ggaagaattg agcttttcgt 1467661 atccgttgac agcgatatgc ttgttgagaa aaggcttgaa attgattggc cgctgctcga 1467721 tgagtttgtc gcagccgcga gagatatgaa gaagcggtat caattgtctg cagagcccga 1467781 tgtaatggat ttctttaagc ttgatcatgt cgtccaggtt catgaagaac agacgcaaaa 1467841 tgacaagctg gaggcgttga tcatcgatgc tgcagaagaa gcggtaaaag gtctctgtga 1467901 aatgcgtgaa aaagaggggc tgctcttagc gaaagactgc ctgatgcata ttgatcagct 1467961 tgaagagctg gtgagagaaa ctgaattgct ggctgcagat gtcgtatctc gttaccggga 1468021 acggctgtat gccagaatca aagaatggac tgaagacgta ttagacgaga gccggcttgt 1468081 aacagaatgc gctatttttg cagaccgctc tgatatcact gaagagatta caaggctgaa 1468141 gagccacttc gcccagtttc gtgatatatt agctagtggc ggagctgtcg ggcgcaaact 1468201 cgactttctt gttcaggagc tcaatcggga agcaaatacg atcggctcaa aagcaaatga 1468261 tcatcagatc acaaagcttg tcgttgaaat gaaaagttct attgaaaaaa taaaagaaca 1468321 agtgcaaaat atagaatagt gactgtgcgt attgtttaca gacggtctta ctaggctaaa 1468381 ctagagacgt ctattttaca gggggaacgt agaagatgac gattaaactg attaatatcg 1468441 gatttggcaa tatcatctcc gccaatcgga tgatttcgat tgtcagcccg gagtctgcgc 1468501 caatcaaacg gatgattcag gatgcaagag accgcggaat gctaattgac gctacatacg 1468561 gacgaagaac ccgtgcagtt gtcgtcatgg atagtgatca cattatctta tctgccgtcc 1468621 agcctgagac agttgcacac agactttctg ttaaagaaga aattatggat gaagggcagg 1468681 ggtaattgcc gcatgaaaga aagagggtta ttaatcgttc tctcaggtcc ctcaggagtt 1468741 ggtaaaggaa cggttcgaca agcgatcttt tcgcaggaag acacaaaatt tgaatattcg 1468801 atttcagtaa ccacaagaag tccaagagag ggcgaagtga acggagtcga ttattttttc 1468861 aaaacaagag acgaattcga gcaaatgatt gcggacaaca agctgcttga atgggcagag 1468921 tatgtcggca attattacgg cacgccagtc gattatgttg aacagacgct tcaagatgga 1468981 aaagacgtct ttttagaaat tgaagttcaa ggggctcttc aagtgagaaa tgctttcccg 1469041 gaaggcctgt ttattttcct tgcgcctcca agcctttctg aactgaaaaa cagaatcgtg 1469101 acacgaggaa cagaaacaga cgctctgatt gaaaatcgaa tgaaagccgc aaaagctgag 1469161 atcgaaatga tggatgctta tgactatgtc gttgaaaacg ataatgtcga aacggcttgc 1469221 gataaaatca aagcaatcgt tcttgctgaa catttgaagc gtgaacgcgt tgcaccaaga 1469281 tataagaaaa tgctggaggt tgaataatca atgttagatc cgtcaattga ttctttaatg 1469341 aataaattag attcaaaata tacgctggtg actgtttctg cgagacgtgc ccgtgaaatg 1469401 caaatcaaaa aagaccaaat gattgaacat acgatttcac acaaatatgt aggcaaagct 1469461 ttagaagaaa ttgatgcagg cctgctttcg tttgaaaagg aagaccgcga atagtagcac 1469521 aagtagcaac ctatatcatg taggttgtta tttttttccg tgcggttttg taaagtgcag 1469581 agggggagaa ttcattgctt aacaatcgaa atgtgttact ttgcgtgagt ggaggcatcg 1469641 ctgtttataa agcctgtgcg ttaacgagca agctggttca ggcaggagca aatgtcaaag 1469701 tgattatgac tgaatccgct tgccgattcg tttcaccgct gacatttcag gcattgagcc 1469761 gccacgaagt ctatacagat acatttaaag aacaaaatcc aagcgtcatt tctcatattg 1469821 atgccgcaga ctgggccgac ttgattatcg tagcgccggc tacggctaat gtgattggaa 1469881 aactggcaaa cggcatcgct gatgatatgc tgacgacaac attgttggca gcaacggctc 1469941 ccgtttggat cgcgccggca atgaacgttc atatgtatga ccacccggca gtcaaacgaa 1470001 acatttctgt tctttatcag gacggttatt gttttattga gccaagtgag ggctatttag 1470061 catgcggtta cgtaggaaaa ggcagattgg aagagccgga aaacatcgta aagctggccg 1470121 aaaaacattt tgctgaagaa acatccgctc ctttagaagg caagcatgtg gtcattacag 1470181 ccggcccaac gcgggaagcg attgatcctg tccggttttt taccaataaa tcgacgggca 1470241 aaatgggcta cgcactggcg gaggctgctg ttcagctcgg cgcacgggta atcttaattt 1470301 ctgggcctgt ttcacttgat cagcctaaag gccttgctga gtttatccct gttcaatcgg 1470361 ctgcggatat gcgcgaagct gtgctctctg tgtatgacgc aagcgatata gtcattaaaa 1470421 cagctgcggt agccgatttt acgccgaaaa cagtatttga ccataaaatg aaaaaacaag 1470481 acggcggcat gaccttagaa ctgaaaagaa cagtcgatat tttgaaagaa ttgggcgaga 1470541 aaaagaaaga gcagattttg gtcggatttg ccgccgaaac acaagacatt gaacactatg 1470601 cacgtaaaaa gctcgccgct aaaaaccttg atttgattgt ggcaaatgat gtgaaagcaa 1470661 atggggccgg ttttggtgct gatacgaata tcgtgacaat ctttttcaaa gacgggcata 1470721 aacgcgaact cccgattatg tctaagctcg atgtttcttt tgaaatcctt caggagatcg 1470781 cagccctctc aaaacaaacc ggagagcgct catgaatttt gcagaagtca tcgttgatgt 1470841 cagcaccaaa aatatagaca ggccttttga ttataaaatc ccagaccatc tgaagggcat 1470901 gatcaaaacg gggatgcggg tcattgttcc gtttggcccc cgtaagattc aagggtttgt 1470961 gacagcagtc aaagaagcat ctgacctatc gggaaaatct gtcaaggaag tagaggattt 1471021 attagatctt acacctgttc tgacagagga gcttatgatt ctgtcatcat ggctgtcaga 1471081 caaaacgctg tcttttaaaa taacggcgct tcaagcaatg ctgcctgccg ccttaaaggc 1471141 gaaatatgaa aaagaattaa aaattgcaca cggagccgat cttccgccgc aagtggaacg 1471201 gctgttttct gaaacaaaga cgctgctgta ttcagatata cccgatcatg agacgctgaa 1471261 actgattcaa aggcatgttc aaaaagggga cattgacgtg acgtataaag tcgcgcaaaa 1471321 aaccaataaa aaaatggtca ggcatattca ggcaaatgcg agtaaagaag agcttgctaa 1471381 gcaggctgag ggattgtccc gccaagcagc aaaacagcag gcgattcttc actttctcat 1471441 ctctgagccg gaaggtgtga aaattcctgc ggcggaattg tgcaaaaaaa cggacacgag 1471501 ctctgcaacc atcaaaaccc ttatccaaaa agggcttttg aaggaaagct atgaagaggt 1471561 ttacagagat ccctatcagg acaaaatgtt caaaaaaaca gagcccctgc cgctgacaga 1471621 cgaacagagg gctgccttcg agcccatacg cgagacattg gacagcgatg agcataaagt 1471681 gttcctcctt cacggcgtga caggaagcgg aaaaaccgaa atttatctgc aatcaattga 1471741 aaaagtactg gcgaaaggaa aagaagccat cgtcctcgta ccggaaatat cgctgacgcc 1471801 gcaaatggtc aaccgcttca agggccgctt cggctcccag gtggcagtca tgcacagcgg 1471861 tttatccaca ggagaaaaat atgacgagtg gcgtaaaatc caccggaagg aagtacggct 1471921 tgtcgtcggt gccagatccg ccatttttgc tccgtttgaa aatctcggaa tgataatcat 1471981 cgatgaagag cacgagtctt cctataaaca ggaagaaatg ccgcgctatc atgcgaaaga 1472041 ggtggcaatc aagcgggctg agcatcacag ctgcccggtt gtattaggga gtgctacgcc 1472101 gacattagaa tcatatgcta gagcgcaaaa gggcgtatac gagcttcttt cactgaagca 1472161 ccgtgttaac catcgggtga tgcccgaggt ttcgcttgtc gatatgagag aggagcttag 1472221 aaacggcaat cgctcgatgt tttcagttga attgatggaa aagcttgaag aaacgattgc 1472281 caagggtgag caggcggtgc tgtttttaaa taagaggggc tactcttcct ttgtgatgtg 1472341 cagggattgc ggctatgtcc cgcaatgccc gcactgcgac atttccatga cgtatcatcg 1472401 ttacggccaa aggctgaaat gccattattg cggacatgaa gagcctgttc cgcacacttg 1472461 tcctgaatgc gcaagcgagc atatccgctt tttcggaacg ggaacacagc gagtggagga 1472521 agagctgaca aaagtgctgc caagtgcgag agtgattcgg atggatgttg acacgacatc 1472581 acggaaaggc gcccatgaaa aattactgtc agctttcgga gaaggaaaag cggatattct 1472641 tctcggaacg caaatgatcg cgaaagggct tgattttccg aatgtcacgc ttgtcggagt 1472701 gttaagtgct gatacaacac ttcatattcc tgatttcaga tcggctgaaa aaacatttca 1472761 gctgttaacg caagtcagcg gccgggcagg caggcatgaa aagcccggcc atgtcatcat 1472821 tcaaacgtat acaccgtctc attacagtat ccagctgacg aaaacacacg attatgaaac 1472881 gttctatcag catgaaatgg cgcacaggag agagcaatcc tatccgccat actactattt 1472941 ggctcttgtg actgtttctc atgaggaagt ggcgaaagca gcggttacag ctgaaaaaat 1473001 cgctcatttt ttgaaagcaa actgcggagc tgacacgaaa attctcggac caagcgcgtc 1473061 gccgatagcc aggatcaaag atagatatcg ctatcaatgc gtgataaaat acaaacagga 1473121 aacccagtta tccgctttat tgaagaagat actggaacat tataaacgcg aaattgaaca 1473181 aaaacatgta atgatttcaa ttgatatgaa tccttatatg atgatgtaag atctcacgtc 1473241 ttggagggta acaaattggc agtaaaaaag gtcgtcacac atcctgcgga ggttttggaa 1473301 acacctgcgg aaaccgtgac tgtttttgat aaaaagctaa aaaaactgct tgatgatatg 1473361 tacgacacca tgcttgaaat ggatggtgtc ggactggcag cgccgcaaat cggcatttta 1473421 aaaagagcgg ccgtcgtaga aatcggggat gacagaggga gaattgatct cgttaatcct 1473481 gaaattttag aaaaaagcgg cgagcaaacc ggaattgaag gatgcttgag ctttcctaac 1473541 gtctatggtg atgtcacacg tgccgattat gtcaaagtgc gtgcgtttaa ccgtcaggga 1473601 aaaccgttca ttctggaagc gcgaggcttt ttagcaagag ccgtgcagca tgaaatggac 1473661 cacttagacg gtgtgctgtt tacatctaaa ataagtaaat actatacaga agatgaacta 1473721 gcggatatgg aaggatgatt tgatgacgag aatcgtattt atgggaacgc cggatttttc 1473781 agttcctgtt ttaagaaccc tgatagagga cggatatgaa gtagtggggg tcgtcacaca 1473841 gccggaccgt ccgaagggca gaaaaaaagt actgacacct cctccggtaa aggaagaggc 1473901 attgcgccac ggcatcccgg ttcttcagcc ggaaaaagtc agattgacag aagaaattga 1473961 aaaagtgctg gcattaaagc ctgacctgat tgtaacggcg gcattcggac aaattttgcc 1474021 taaagagctt ctcgacagtc caaaatacgg ctgcattaac gttcacgcat cccttttgcc 1474081 ggaactgcgc ggcggtgctc cgatccatta ttccattctg cagggaaaga agaaaaccgg 1474141 gattaccatt atgtatatgg tagaaaaatt ggatgcgggc gatatgatct caaaagtgga 1474201 agtggacatt gaagaaaccg acaatgtcgg aacactgcac gataaattaa gcgttgctgg 1474261 cgcgaagcta ttgtctgaaa cggttccaaa cgttattgcc ggcagcatat cacctgaaaa 1474321 gcaggatgaa gagaaagcga cgtacgcgcc taacattaaa agagagcaag agctgctcga 1474381 ctggtccaga acgggcgaag agctttacaa ccagatccgc ggcttaaatc catggcctgt 1474441 tgcttatacg actctaaacg gacaaaactt gaaaatatgg gcgtcgaaaa aaatagcggc 1474501 accaacaaca gctgagcccg gcacagtcgt tgcagttgaa aaggaaggaa ttatcgttgc 1474561 cacaggtaac gagacggctc tgttattaac cgaactccag ccggcaggca aaaaacgaat 1474621 gaaaggcgaa gactttgtgc gaggcgctca tgttgaagcc ggtgatgtgt taggagtaaa 1474681 caatgaaaaa aactagtgtt cgtgacatcg cccttgaggc gctgatcaaa ttagaacaaa 1474741 accaggcata cagcaacctg ctgctgaaat cggtcattaa atcaaatgaa ctgagtgatc 1474801 agaacagagg gcttttgact gaacttgtct atggtacatt acaaaataag atcgcgcttg 1474861 attatatgct taaaccgttt atcaataagc ctcaaaaggt aaagccgtgg gtgattcagc 1474921 ttcttcgcct atccttatat caaatggagt atttggagaa gattccagac agggcagcca 1474981 ttcatgaagc ggttgagatt gctaaaatcc gcggacacaa aggcattgct tcatttgtca 1475041 acggcgtgct ccgttctatt cagcgcgaag gtgttccatc ctttgacgcg atcgaagatc 1475101 ctgtccgccg gctggcgaca gaaacaagcc atccggaatg gcttgtgaaa gagtgggcgg 1475161 atgcgtatgg atttgaagct gcggaaaaga tttgccgcat ccatctcatt ccgccgaaac 1475221 agacgctgcg tgtcaatcaa atgaaagcag acagagctga gctgcttgac caaatggctg 1475281 ctgagggaat cgaagttgaa aaaggcgacc tcgctgaaga tgctgtgaag ctcttaaagg 1475341 gaacaattgc cggaactcat ttcttccaaa acggcgaagt ttctatccag gatgagagct 1475401 ccatgctcgt cgcccgcgcc cttgatccta agtcagatga aacagtgctt gacgcgtgtg 1475461 cggcgcctgg cggaaagtcg gctcatatcg cagaattaat gaagaacaag gggagcgtta 1475521 cgtcgcttga tcttcacaaa cataaagtga agctgatcaa agaagcggca gatcggcttg 1475581 gcctgacaat cattcatgcg gaaacaatgg atgctagaaa agcgggggaa acgtttgaaa 1475641 acgaacagtt tgaccgaata ttggtcgatg ccccgtgctc aggtttcggt gttatcagaa 1475701 gaaagccgga catgaaatac acgaaaaaac ctgacgacag cgcccgtcta gctgaaatcc 1475761 agctgtcgat cttgagggaa atcgcaccat tagtaaaaaa aggtggcact cttgtctaca 1475821 gtacgtgtac aatggaccgg acagaaaatg atgaagtaat acatgcgttt atacaagaac 1475881 atcctgattt tgaacccgat ttgtctcttg aaaagcggct gcctgaaaag gtgagaccct 1475941 ttgttcggga tggaaggctt caaatccttc ctcattattt cggaacagat ggtttcttta 1476001 tttgcagcat gagaaagaag ggataagcaa tggcagaact taataaaaca aaagtaagaa 1476061 aagaattgcg gacagagcgt ccgtctattt attcttttga attagatgaa atcaaacaat 1476121 ggctgacaga caatggagag aaaccgttcc gtgcagccca gatctttgaa tggctatatg 1476181 aaaaacgcgt atcttctttt gaagatatga caaacctctc aaaggatctg cgtgagaaat 1476241 taaacactcg ctttgtgtta acaacgctga aaacggctgt taaacaaacc tctcaagacg 1476301 gtacgatgaa gtttttgttt gagcttcatg acggttatac catcgaaacc gttttaatga 1476361 gacacgagta tggcaattct gtatgtgtaa cgacacaagt cggctgccgt attggctgca 1476421 cattctgcgc gtcaacgctt ggaggcttaa aacgaaacct tgaagcaggg gaaattgtcg 1476481 ctcaagtagt caaagtgcaa aaagctcttg atgaaacgga tgaacgcgtc agctctgtcg 1476541 tgatcatggg aatcggcgaa ccttttgata actttaacga aatgctcgct ttcttgaaaa 1476601 tcattaacca tgacaagggc ctgaatatcg gtgctcgcca tattacggtc tctacgagtg 1476661 gaatcatccc gaaaatttac gaatttgctg atcagcaaat gcagattaac tttgcaattt 1476721 ctctgcacgc gccgaacaca gaaatcagaa gccgtttgat gccgattaac agagcatata 1476781 aactgcctga tctaatggaa gccgttaaat attatattaa taaaacagga cgccgtatca 1476841 gctttgaata cgggctgttc ggaggcgtaa acgaccaggt ggaacacgcc gaagagcttg 1476901 ccgacttgct ggaaggagtc aaatgccacg tgaacttgat tccggtaaac tacgtgcctg 1476961 aacgggacta tgtgcgcaca ccgcgtgatc agatttttgc ttttgaaaaa acgctgaaat 1477021 cccgcggagt aaatgtcaca atccgaagag agcaaggaca tgacattgac gcagcctgcg 1477081 gtcagcttcg cgcgaaggag cgtcaagacg agacgaggtg atgagggttg ttaacagcct 1477141 taaaaacaga tacaggaaaa atccgccagc ataatgaaga tgatgcgggg atattcaagg 1477201 ggaaagatga atttatatta gcggttgtcg ctgatggcat gggcggccat cttgctggag 1477261 atgttgcgag caagatggct gtgaaagcca tgggggagaa atggaatgaa gcagagacga 1477321 ttccaactgc gccctcggaa tgtgaaaaat ggctcattga acagattcta tcggtaaaca 1477381 gcaaaatata cgatcacgct caagcccacg aagaatgcca aggcatgggg acgacgattg 1477441 tatgtgcact ttttacgggg aaaacggttt ctgttgccca tatcggagac agcagatgct 1477501 atttgcttca ggacgatgat ttcgttcaag tgacagaaga ccattcgctt gtaaatgaac 1477561 tggttcgcac tggagagatt tccagagaag acgctgaaca tcatccgcga aaaaatgtgt 1477621 tgacgaaggc gcttggaaca gaccagttag tcagtattga cacccgttcc tttgatatag 1477681 aacccggaga caaactgctt ctatgttctg acggactgac aaataaagtg gaaggcactg 1477741 agttaaaaga catcctgcaa agcgattcag ctcctcagga aaaagtaaac ctgcttgtgg 1477801 acaaagccaa tcagaatggc ggagaagaca acattacagc agttttgctt gagcttgctt 1477861 tacaagttga agagggtgaa gatcagtgct aatcggcaag cggatcagcg ggcgttacca 1477921 aattctccgc gtcataggcg gcgggggaat ggccaacgtg tatttagctg aggatatcat 1477981 tctagaccgt gaagtcgcaa ttaaaatcct gcggtttgac tatgcaaatg acaatgaatt 1478041 tatcagacgt ttccgcagag aagcccaatc cgcatcaagc ctcgatcacc cgaatattgt 1478101 cagcatttat gatttgggcg aggaagatga tatttattat attgtcatgg aatacgttga 1478161 aggcatgacg cttaaagaat acataacagc aaatgggccg cttcacccta aagaagcgct 1478221 gaacatcatg gagcaaattg tctcagccat cgctcatgcc catcaaaacc agattgttca 1478281 cagagacatc aagccgcata acattttgat tgatcatatg ggaaatatca aagtaacgga 1478341 ttttggaatt gcgacggcac taagttcgac cacaatcacc cataccaatt cagttctggg 1478401 ctcggtccat tacttatcac ctgaacaggc ccggggcggc ttagccacaa aaaaatcgga 1478461 tatttatgcg cttggaatcg ttctatttga gcttttaacc ggccgtattc cgtttgatgg 1478521 agagtcagca gtcagcatcg ccttgaagca tcttcaagcg gaaactcctt cggcaaaaag 1478581 gtggaatcca tcggtccccc aaagcgttga aaacatcata ctcaaggcaa ctgccaaaga 1478641 tccttttcat cgctacgaaa cggctgaaga catggaagca gacataaaaa cagcttttga 1478701 tgccgacaga ctcaatgaaa agagatttac gattcaagaa gatgaagaaa tgacaaaagc 1478761 gatacctatc attaaagatg aagaacttgc taaagctgct ggcgaaaaag aagctgaagt 1478821 gacaaccgca caagaaaaca aaacaaagaa gaacggcaaa agaaaaaagt ggccgtgggt 1478881 tttgctcacg atatgcctcg tttttatcac agctggaatt cttgctgtca ctgtttttcc 1478941 gtcgcttttc atgcctaagg atgtcaaaat acctgatgtc tccggaatgg aatacgaaaa 1479001 agccgcaggg ctcttggaaa aagaaggttt acaggttgat tccgaggtgt tggaaatctc 1479061 agatgaaaaa attgaagagg gcctgatggt aaaaacggat cctaaagcgg ataccacagt 1479121 caaagaaggc gccacggtca ccctttataa gagcaccgga aaagcaaaaa cggagatcgg 1479181 tgatgtgaca ggccaaacgg tcgaccaagc aaaaaaagcg ttgaaggacc aagggtttaa 1479241 tcatgtaaca gtaaatgaag tgaatgacga gaaaaatgcg ggcactgtca ttgaccaaaa 1479301 tccttcagca gggactgagc tggtcccgag tgaagatcaa gtcaaactta cagtcagtat 1479361 cggacccgaa gacattacgc ttagagactt gaaaacctac agtaaagaag cagcgtctgg 1479421 atatctggaa gacaacggat tgaagcttgt agaaaaagaa gcatactcag atgatgttcc 1479481 agaaggacag gttgtcaaac aaaaaccagc agcaggtacg gcagtaaagc cgggaaacga 1479541 agttgaagtg acattctctc tcggaccaga gaaaaaacct gcgaaaacag tgaaagaaaa 1479601 ggtcaagatc ccctacgaac cagaaaatga aggggacgag cttcaagtgc aaatcgcggt 1479661 tgacgatgcg gatcacagca tctctgacac ttacgaagaa tttaagataa aagagccgac 1479721 tgaacgaacg atcgaactaa agattgaacc aggccaaaaa gggtactatc aagtaatggt 1479781 aaacaataaa gttgtcagct acaaaaccat tgagtatccg aaagatgaat aacaaggagg 1479841 gaaaatatgc ctgagggcaa aattattaag gcgctaagcg gcttttacta tgtactggat 1479901 gaatcagagg attcagataa agtaatacaa tgcagaggaa gaggcatttt cagaaaaaac 1479961 aaaattaccc ctcttgtcgg tgattacgtt gtgtatcaag ctgaaaatga caaagaagga 1480021 tatctaatgg aaattaaaga aagaaccaac gagcttatca ggccgccaat ttgcaacgtt 1480081 gatcaagcgg tccttgtttt ctcagcggtt cagccttctt tcagcacggc attgctcgac 1480141 cgcttcctgg ttctcgttga ggccaatgat attcagccga ttatatgcat tactaaaatg 1480201 gatctgattg aagatcaaga tacagaagat acgatacaag cctatgcaga agactatcgg 1480261 aatattggtt atgacgtata ccttacctcc tctaaggacc aagatagttt agcggacatc 1480321 atcccgcatt ttcaggataa aacaacggta tttgccggtc agtccggtgt tgggaaatcc 1480381 tcgcttctca acgcgatcag tccggagctc ggattaagaa caaacgagat ttccgagcat 1480441 ttgggccgcg ggaaacacac aacccgccac gtggagctga ttcacacgtc cggaggtttg 1480501 gttgcagata caccgggatt cagctcgctt gaatttacag acattgagga agaagagctg 1480561 ggctatacct tccctgatat cagagaaaaa agctcttcat gcaaatttag aggctgttta 1480621 catctgaaag agccgaaatg tgcggtgaaa caagctgttg aagacgggga attaaagcag 1480681 tatcgctatg accattatgt tgaatttatg acggagatta aagacagaaa gccgaggtat 1480741 tagcataatg ataaaggttg caccatctat tctttccgct gattttgccg ctttaggcaa 1480801 tgagattaaa gatgtagaaa aaggcggagc cgattgtatt catattgatg ttatggacgg 1480861 ccattttgtc ccgaatatca caatcggtcc gctgattgta gaagcggtcc ggccggtaac 1480921 ggatctgccg cttgatgtcc atttaatgat agaagagccg gatcgttata tcccggcttt 1480981 tgcgaaagca ggcgcagata tcctgtctgt gcatgctgag gcatgtccgc acctgcaccg 1481041 taccatccag ctcattaaag agcaaggagt gaaggccgga gtagttctaa acccgcatac 1481101 ccctgtacaa gtcatcgaac atgttttcga cgatcttgat cttgttcttt taatgacggt 1481161 gaacccgggc ttcggcgggc agaaatttat tcattcagtc cttcctaaaa taaaagaggt 1481221 taagcgaatg gcggatgaaa aaggaaaaaa agatctgtta attgaagtag acggcggcgt 1481281 caacaaagaa accgctccgc tcgtcattga agcgggcgca aatttactcg ttgccggttc 1481341 agctgtttat ggccagtctg accgcaaaaa agcaatttct gaaatcagag gaagtaaata 1481401 agcagcttta gaaaagagct gggcatacaa tagcctaagc tctttttcct gtatgcagag 1481461 aaaggaatca gagatgaaaa caattaatat cgttgcggga ggcccgaaaa atctcattcc 1481521 cgatctaacc ggctatacgg atgaacacac gctttggatc ggtgttgaca aaggcaccgt 1481581 cactctctta gatgccggga tcattcctgt tgaagccttc ggagattttg acagcataac 1481641 ggagcaagaa cgccggcgaa tagaaaaagc cgctcccgcc cttcatgtgt atcaagcaga 1481701 aaaagatcaa acagatttag acctcgccct tgattgggcg ctggaaaagc agccggatat 1481761 tattcagatt ttcggcatta caggcggcag agctgatcat tttttaggaa acattcagct 1481821 tctgtataaa ggtgtaaaaa cgaacataaa aattaggctg atagacaaac aaaatcatat 1481881 tcaaatgttc cctcctggtg aatatgatat tgagaaggat gaaaataagc gatatatctc 1481941 cttcataccg ttttccgaag acatacatga gctgaccctg accggtttta aatatcctct 1482001 aaataattgt catattacgc tcggttcaac actatgtatt agtaacgaac tcattcattc 1482061 acgaggtact ttttcgtttg caaaaggcat attaataatg ataagaagca cggattaagc 1482121 atgtgctttc attcaattgc tgaaaacaat gaacaaggcg gttacgggac gttataggag 1482181 gggacaaaaa tgaaatttta caccattaaa ttgccgaagt ttttaggagg aattgtccgg 1482241 gcgatgctgg gctcatttag aaaagattaa tgcccagggg ttcaaagccc tctttcacca 1482301 cataaaaacg cctgccacat atcggggcag gcgttcattt tgttatacac gctcaacttt 1482361 accggatttc aaagctcgag cagatacata tactttttta ggttttccgt tcacaaggat 1482421 acgaaccttt tgaagattcg cgccccaagt gcgcttagaa gcgttcattg cgtgagaacg 1482481 gttattccca gctgttgttt ttttacctgt gataacgcat ttacgtgcca tttgtttccc 1482541 tcctcacttg cacaaaacat ctacttttta acattcatat aatcttagat gctttcgata 1482601 tggatacttt aaataattta ccacagctaa aaaacgtttg caactattgt ttcatcatct 1482661 ttcaagaaaa ttcacttgac atcttgcgga aacagcagcg ctatagtata tgtagaggta 1482721 cggccagcga ttattgcctg gtcttttcat aatggaaacc atatagtaga atagctgtaa 1482781 ctctatgcat tcgaaggagg aactagtgtg tccattgaat taagaacgaa gtacggacag 1482841 attgatatat ctaatgaagt catcgcgatg gttgcaggag gcgcggcggt tgactgttac 1482901 ggcattgtcg gcatggcctc taaaaaccag attaaagacg gactgactga aatccttcgg 1482961 aaagagaatt tcagcagggg tgtccaagtt cgccaagaag gagaacagat acatatcgac 1483021 atgtatatca ttgtcagcta cggcacgaaa atttctgaag tggcacataa tgtccaaaca 1483081 aaagtaaagt acacagtaaa tcaaaccatc ggactggcag tggattctgt caatatttat 1483141 gtccaaggcg tacgagtgac gaacccgtag ttaggaggag taggattgtc tatcagaaca 1483201 ttagacggca gaacctttgc cgagatgatt cttgcgggag cgcagaatct gtctcaaaac 1483261 gccagtgcag ttgatgcact gaacgtgttc ccggtgccgg acggtgatac gggaacaaat 1483321 atgaacctgt cgatgacttc cggagcaaga gaagttgaac aaatggatac ggatgatatc 1483381 gggaaggtgg gctccgcgtt atctaaaggg ctgctcatgg gagcacgcgg aaattcagga 1483441 gttatcctat cccaattgtt ccgcggattt agcaaaaaca ttgaaacgaa aaaagaaatt 1483501 aatgcacttg agtttgccgc tgcgctgcaa gcaggtgtag acatggcgta taaagctgtc 1483561 atgaaacctg tagagggcac cattttaaca gttgcaaaag acgctgcaaa aaaagcaatg 1483621 atcttagcag aaaaagaaac cgatatcact gcgctgatga ctgcagtgac agaagaagca 1483681 gaggcgtctt taaaccgcac ccctgaattg ctacctgtcc taaaggaagt aggagttgtc 1483741 gatagcgggg gcaaaggcct gctctgtgtg tatgaaggtt tccttgcttc attaaaaggt 1483801 gaaactgtac ctcagaaagc agttcttccg tcacttgacg acatggtcag cgcagagcat 1483861 cacaagagcg cgcaaagcat gatgaatacc gaagatattg aatttggatt ctgtaccgaa 1483921 gtgatggtta ggcttgatca gacaaaaaga gagttcgacg aaggcacgtt caggcaagac 1483981 ctcagccagt tcggagattc tctgcttgtg attgcggatg aatcgctggc gaaggttcat 1484041 attcatgctg aagagccggg aaacgtgtta aactacgccc agcattacgg tgaattgatc 1484101 aaaataaaaa tagaaaatat gagagaacag catacctcta tcatcagtca agaaagcaaa 1484161 cctgcagaca acgaaacacc gccggcaaaa cagccgtatg gcattgtgac tgtagcgatg 1484221 ggagaaggaa ttgcagacct atttaaaagc attggcgctt ctgttgtgat tgaaggcggc 1484281 cagaccatga acccaagcac tgaggatatt gttgatgccg tgaagtctgt aaatgcagat 1484341 acggtattta tcctgcctaa caactccaac attatcatgg ctgctaacca agcggccagc 1484401 gtagtggatg aacaggtttt tgtcattcct gctaaaacgg ttccgcaagg gatgtcagct 1484461 ctgctggctt ttaacccgga tcaagaagct gaagcgaacg aggccaatat gctaagcgcc 1484521 attcagcaag taaaaagcgg acaggtgacg ttctcagtca gagatactca tattgacggt 1484581 aaagacatta aaaaaggcga ctttatgggc attctgaatg gaacgattat cggcacttct 1484641 gaaaatcagc tgtcagccgc gaaaatgctg ctgtcagaaa tgatcggaga agatgatgaa 1484701 atcgtgacca ttctatatgg tgaggatgcg tctcaggaag aagctgagca gcttgaagcg 1484761 tttctcagtg aaaagtacga ggagattgag gttgagatcc acaatgggaa acagcctctg 1484821 tattcgtata tagtttcagc agaatagaag ggcaatttgc ccttctattc ttatgtctgc 1484881 ttttaagtgc ggcagcgctg taacgcgccc gcttgccatt ttatatctga tcaattagtc 1484941 tagaagcaaa gcgctaataa gctctggttc ataaggagga atagcatgaa atacagaagc 1485001 gtttttgata ttatcggccc ggttatgatc ggtccgtcca gctctcatac agcgggagct 1485061 gctagaatcg ggagagtggc cagaagttta tttggcagag agcctgagcg catcattgta 1485121 tctttttacg gctcgtttgc ggaaacgtat aagggccacg gcacagatgt cgcgattatc 1485181 ggcggattgc ttgattttga tacattcgat gaacggatta aaaccgctat acaaattgca 1485241 gaagctaaag gaattgatat agagtttcgg gtagaagacg cagtcccggt ccacccgaac 1485301 acagcaaaaa tcaccatttc tgatgaaaag ggtgagctgg aactgacggg tatttcgatt 1485361 ggcggaggaa agattgaaat cacagaattg aatggttttg agctccggct gtcaggaaat 1485421 catccggcca tattagttgt tcataatgac aagtttggca caattgccgg tgttgccaat 1485481 gttctggcga aattttcaat caacgtagga catatggaag tagcccggaa agatatcggc 1485541 cagcttgcgc tgatgacaat agaggtcgat caaaatattg acgaccacat tctcgacgag 1485601 ctgtcgaagc tgccgaatat tattcaagtg acaaagattg ctgactagcg aaaagggtca 1485661 ggaggagcca gttatgtttc gtaatgtaaa agaattaatt gagattacta aagaaaaaca 1485721 aatattgatc tctgatgtga tgatagctca agagatggaa gtaacagaaa aaacaaaaga 1485781 ggacattttt cagcagatgg atcataacct gtctgttatg gaagcggcgg ttcagaaagg 1485841 actcgaggga gttacgagcc aaacgggctt aacaggcgga gatgccgtta aattgcaggc 1485901 ctatattcga tcaggaaaaa gcctgtctgg cccgctgatt ttagatgctg tatcgaaagc 1485961 cgttgcaaca aatgaagtaa atgcagccat gggaaccatc tgtgcgacac cgactgcagg 1486021 ttctgccggt gtggtgcccg gtacgttatt tgctgtaaaa gaaaagctga atccaacaag 1486081 agaacaaatg atccgctttt tgtttacagc cggggctttc ggatttgtcg tggccaataa 1486141 cgcaagcatt tccggcgccg ccggaggatg tcaggcagag gttggatcag cttcaggcat 1486201 ggcggctgcg gctattgttg aaatggcagg aggaacaccc gaacaaagcg cggaagccat 1486261 ggccattaca ttaaaaaata tgctaggcct cgtgtgcgac cctgttgcag ggcttgttga 1486321 ggtgccttgc gtgaaacgga atgcgatggg cgcgtcaaat gcgatgattg ctgctgatat 1486381 ggcattggcg ggcattacaa gccgtattcc atgtgatgag gttatcgatg ccatgtataa 1486441 aataggccaa acgatgccaa ctgcacttag agaaacaggc cagggcggtt tagcggcaac 1486501 accgacagga agagaattag agaaaaaaat tttcggagga gcgctaggtt cacgtgaaac 1486561 aacatcagca aactagtata gctaacatta agggtattgg gccggaaaca gaaaaaacat 1486621 tgaatgaact cggtatttat gacatttctg atcttctgaa ttatttccct tatcgctatg 1486681 atgactacga gctgagggat ttagaagaag taaagcatga tgaaagagtc acagtcgaag 1486741 ggaaggttca ttcagagcct tctcttacct attacggaaa aaaacgaaac aggctgacat 1486801 tcaggcttct ggtcggccac tatttaatca cagccgtatg ttttaaccgg ccttatttga 1486861 agaagaagct ttcgctcggc tctgtggtga cggtttcagg taaatgggac aagcaccgcc 1486921 aaaccatctc tgttcaggag ttgaaaaacg ggccgcatca agaagacaaa agcattgaac 1486981 cagtgtattc tgtgaaagaa aatgttaccg tcaaaatgat gaggcgcttt attcagcagg 1487041 cgctgaccca atatgcagac tcacttcctg atcctcttcc ggaaaagcta agaaaaagct 1487101 ataaactgcc tgactattat caagcgttaa aagcaatgca ccagcctgaa acaagggaag 1487161 cattaaagct tgccagacgg cggtttgttt atgaagaatt tttgttgttt cagttgaaaa 1487221 tgcaggcgtt ccgaaaggcg gaaagagagc agacacaagg gatacggcag cgtttttcaa 1487281 acgaagaact catgagattt atcaaaagcc tcccgtttcc cctcacaaac gcccagtcac 1487341 gcgttcttcg cgaaataaca gcagacatgt cttctccata cagaatgaac cgtcttcttc 1487401 aaggggacgt tggatcagga aaaacggcag tcgccgccat tgcactgtat gccgcgatcc 1487461 tatccggata ccaaggagcg ctcatggtgc cgacagaaat tctggccgag cagcatgctg 1487521 attcgctcgt ttcgctattt gaaaaatggg acgtcagcgt tgctcttttg acaagctctg 1487581 ttaaaggaaa gcggcgaaaa gaactgcttg agcgtcttgc ggcgggtgag attgatattc 1487641 ttgtaggaac ccatgcttta atccaagacg aggtggagtt taaggcgttg agtctcgtta 1487701 ttactgatga acagcacaga tttggagttg agcagcgcaa aaagcttcgg aacaaagggc 1487761 aggatcccga tgttctcttt atgacagcca ctccaatccc aagaacatta gcgatcacag 1487821 tattcggtga aatggatgta tctgtcattg atgagatgcc ggctggacga aagcgaattg 1487881 aaacctattg ggtaaaacat gacatgcttg atcgtatttt ggcatttgtc gaaaaagaat 1487941 taaagcaagg caggcaggct tatatcatct gtccgctgat tgaagaatca gataagcttg 1488001 atgtgcaaaa cgccattgac gtgtacaata tgctttctga tatttttcgg ggaaaatgga 1488061 atgtcggcct tatgcatgga aagctgcatt ccgatgaaaa agatcaggtc atgagagaat 1488121 tcagcgcaaa tcactgtcaa attctcgtat caaccactgt tgtggaggtt ggcgtaaatg 1488181 ttccgaatgc aacaattatg gtgatttatg acgccgaccg tttcggacta tcacagcttc 1488241 accagctgcg cggccgtgtt ggacggggtg agcatcaatc tttctgtatt ctgatggctg 1488301 atccaaaatc agaaacaggg aaagaacgga tgaggatcat gtcggagacc aatgacggtt 1488361 tcgagctgtc tgaaaaggat ctggaactga gaggtcccgg tgatttcttc gggaaaaaac 1488421 aaagcggaat gccggaattt aaagtggcgg acatggttca tgattacaga gcgcttgaaa 1488481 cggcaaggca ggatgctgcg aatcttgtgg cttctgacgc gttctggaag gagccggaat 1488541 acgctgtgtt aagagatgaa ttgctgaaga gcggagtaat ggacggggaa aaattaagct 1488601 gagtatcaga agtttttggt gttcagccag aaacaatcgt tgcattccaa tctatgaaat 1488661 tatatactac tattagtacc tagtcttaat tgtccggatg gtgtttagat atgagaagaa 1488721 ataagagaga acgccaggaa ttacttcagc agacgattca agcaaccccc tttattacag 1488781 atgaagaact agcgggtaaa ttcggggtga gcatccagac gatacgtttg gaccgcttag 1488841 agctttccat acctgaactg agagaaagaa ttaagaacgt ggcagagaaa acacttgagg 1488901 acgaagtgaa gtccctgtca cttgatgaag ttatcggaga aattattgac cttgagctgg 1488961 atgatcaggc gatatccatt ttagaaataa aacaggagca cgtgttcagc cggaatcaga 1489021 ttgcgagagg acaccattta tttgcacagg cgaattcttt ggccgttgca gtcattgatg 1489081 acgagctggc gctgactgca agtgcagaca tccgctttac aagacaggta aagcagggtg 1489141 aacgtgtcgt agcaaaagcg aaagtgacgg ctgtcgaaaa agaaaaagga agaacggttg 1489201 tcgaagtgaa cagctacgtt ggcgaagaaa ttgttttttc tggacgcttt gacatgtatc 1489261 gttcaaaaca ttcataaagg tggagcatgc atgagaatag ctgtagatgc aatgggagga 1489321 gaccacgctc ccaaagctgt tattgacgga gttataaaag gtatagaggc atttgatgat 1489381 ctccatatca cacttgtcgg tgacaaaaca acgatagaat cacatttaac aactacatca 1489441 gatcgcatca cggtgctgca cgcagatgaa gtgattgagc ctacggatga accggtccgt 1489501 gccgtgcgaa gaaaaaagaa ctcatctatg gttcttatgg cgcaggaggt tgcggaaaac 1489561 agagctgacg cctgcatttc agcgggaaat accggtgcat taatgacagc cggtctcttt 1489621 attgtcggga gaattaaagg aattgaccgt ccggcgcttg ctccgacact tccgactgtt 1489681 tcgggagacg gatttcttct ccttgatgtc ggcgccaatg tcgatgccaa accggagcac 1489741 ctcgttcaat atgccatcat gggttctgtt tattctcagc aagtgcgcgg tgtcacttca 1489801 ccgagagtcg gacttttaaa tgtcggaaca gaagataaaa aaggaaacga actgacgaag 1489861 cagacgtttc aaattttaaa agaaacagca aacatcaatt ttatcggaaa cgtggaagcg 1489921 cgagaccttt tagatgatgt ggcggatgtt gtagtaacag acggctttac cgggaatgtt 1489981 acactcaaaa cgctggaagg ctctgcgttg tcaattttta aaatgatgag agacgtaatg 1490041 acgtctactt tgacatccaa gcttgcagca gctgtgctga aaccaaaatt gaaagaaatg 1490101 aaaatgaaaa tggagtattc gaattatggc ggagcaagtc tttttggctt aaaagcgcct 1490161 gtgatcaagg cgcacggctc ttcagattca aatgctgtat tccatgcgat tcggcaagca 1490221 agagagatgg tcagccaaaa tgtggctgcg ctcattcagg aagaagtgaa agaagaaaaa 1490281 acagatgagt agtctggagg tttttacatc atgagtaaga ttgcattttt attcccgggt 1490341 cagggatcac aatttatcgg catgggaaaa gagctttatg agcaggtgcc tgctgcaaag 1490401 cgtctgtttg atgaagccga tgaaacgttg gaaacaaaac tcagctcgct tatttttgag 1490461 ggggatgctg aagaattaac acttacatac aatgcgcagc ctgctttgct tacgacaagc 1490521 atcgctgttc ttgagaaatt taaagaatct ggcattacac ctgatttcac agcaggacac 1490581 agccttggtg aatattctgc actggttgcg gctggcgctc tgtctttcaa agatgctgtt 1490641 tatactgtca gaaagcgcgg agagtttatg aatgaagcgg tgccggctgg cgaaggagca 1490701 atggctgcga ttctcggcat ggatgctgaa gcattaaagc aagtaaccga taaagtcaca 1490761 gaggaaggca accttgtaca gcttgcgaat ctcaactgtc ctggccaaat cgtcatttcc 1490821 ggaacagcta aaggggttga gcttgcatct gaactggcaa aagagaacgg cgcaaaacgc 1490881 gcaattccgc ttgaagtaag cggtccgttc cattctgaac tgatgaaacc ggctgctgaa 1490941 aagctgaaag aggtattgga cgcctgtgac ataaaagacg ctgacgttcc ggtcatctca 1491001 aatgtttctg ctgacgtgat gactgaaaaa gcagatatca aagaaaaact tattgagcag 1491061 ctttactctc cggttcgttt tgaggaaagc attaacaagc tgatcgcaga gggtgttacg 1491121 acttttattg aaatcggtcc cggaaaagtg ctttcaggcc ttgtgaaaaa agtgaataga 1491181 cggttaaaaa caattgctgt atcagatccg gaaacgatcg agctggcaat tcaaacgctt 1491241 aaggaggaga atgataatgc ttaatgataa aacggctatt gtcactggcg catcccgcgg 1491301 aatcggccgc tcaatcgccc ttgatctggc aaaaagcgga gcaaatgttg tcgtgaacta 1491361 ctccggcaat gaagcgaaag caaatgaagt ggtagatgaa atcaaatcaa tgggcagaaa 1491421 agcaattgct gtaaaagcgg atgtatcaaa tcccgaagat gtacaaaaca tgataaaaga 1491481 aacattgtct gttttttcta cgattgacat tctggttaat aatgcgggaa ttacaagaga 1491541 caatctcatc atgagaatga aagaagacga atgggatgac gtcattaaca ttaacctgaa 1491601 gggtgttttc aactgcacaa aagctgttac aagacaaatg atgaaacagc gttcaggccg 1491661 cattattaac gtatcgtcta tcgtcggcgt cagcggaaac cctggacaag ccaactacgt 1491721 ggctgcaaaa gccggcgtca tcggtttaac caaatcttct gctaaagagc tcgccagccg 1491781 aaatattacg gtaaacgcaa tagcgccagg atttatctca actgatatga cagataaact 1491841 tgcaaaagac gttcaagacg aaatgctgaa acaaattccg ctcgcgcgct ttggtgaacc 1491901 tagcgatgtc agcagtgttg tcacgttcct agcttcagag ggagctcgtt atatgacagg 1491961 ccaaacgctt catattgacg gcggaatggt gatgtaagtt ttttctcgaa aatttcatcg 1492021 tagtttctct agttttttaa aaacgaatcc actataatac ttgaggggag gtgaattgct 1492081 atggcagaca cattagagcg tgtaacgaaa atcatcgtag atcgccttgg cgttgatgaa 1492141 gcagacgtca aacttgaagc ttctttcaag gaagacttag gtgctgattc cctagatgta 1492201 gttgagcttg ttatggaact tgaagacgag tttgatatgg agatttctga cgaagatgct 1492261 gaaaagattg caacagtcgg cgacgctgtg aactacatac aaaaccagca ataagctgat 1492321 gctaaaagtc ccgccgaaac gcggggcttt agccctttat tcgtgcagtt attacagcat 1492381 gccgctttta cgcgcgctgt atccggttta gtcagagaag cgcggtgaac ctgatgtgcc 1492441 tatggaggtt actatgtcaa aacactcaca ttataaagat aaaaaaaagt tctataaaaa 1492501 agtagaacaa tttaaagagt ttcaagaacg gatttcggtt cactttcaaa atgaaaagct 1492561 tttgtatcaa gcatttacac attcatctta tgtgaatgag catcggaaaa agccgtatga 1492621 agataatgaa aggcttgaat ttttaggtga cgctgttttg gaactgacga tctccagatt 1492681 cttatttgcc aaatacccgg ctatgagtga aggagatttg acgaaattga gagccgcaat 1492741 tgtttgcgaa ccgtctctcg tttcattggc tcacgagctg tcattcggcg atcttgtcct 1492801 gttgggtaaa ggcgaggaaa tgacaggcgg aagaaagcgt cctgctctat tggcggatgt 1492861 ttttgaggca tttatcggag ccttgtacct tgaccaagga ttagagccgg tcgaaagttt 1492921 cttaaaagtt tatgtgttcc ctaaaattaa cgatggtgct ttttctcatg tgatggattt 1492981 caaaagccag ctgcaggaat acgtgcagcg ggacggcaaa ggctctctgg agtataaaat 1493041 ctccaacgaa aaaggacctg cgcacaaccg tgaatttgaa gccatcgtat ctctaaaagg 1493101 tgaaccactc ggagtcggaa acggccgttc aaagaaagaa gccgaacagc acgctgctca 1493161 ggaagcttta gctaaattgc aaaaacacca tacgaaacaa taaaatcccc cttatgactc 1493221 agggggattt cagtatgtat gccgtcttat ttgaccaatg tttatgatag aattgaaata 1493281 cttattacat aaggaggatc gctatgttcc tcaaacgttt agacgttata ggatttaaat 1493341 catttgcaga acggatttcc gtagacttcg ttaaaggcgt gacagcagtt gtcgggccga 1493401 acggaagcgg aaaaagcaac atcacggatg ccattcgctg ggttctcggc gaacaatcgg 1493461 cacgctctct tcgcggcgga aaaatggaag acatcatttt tgctgggagt gattcaagaa 1493521 agcgattaaa tctagctgaa gttacgctta ctcttgataa tgatgatcat ttcttgccaa 1493581 ttgacttcca cgaggtgagt gtcacaagac gtgtgtacag atcaggtgag agtgagtttc 1493641 tgattaacaa tcagccatgc cgcttgaaag atattattga tttatttatg gactctgggc 1493701 ttggtaaaga agcattttct attatcagcc aagggaaagt ggaagagatc ctgagcagca 1493761 aagcggagga tcgccgcagt atctttgaag aagcggccgg ggtgcttaaa tataaaacga 1493821 gaaagaaaaa agcagaaaat aaactgtttg agacacagga caatctaaat cgggtagaag 1493881 atatattaca tgagcttgaa ggacaggttg aacctcttaa aattcaagct tcaatagcga 1493941 aagactacct tgagaaaaag aaagagctgg agcatgttga aattgcgctg actgcctatg 1494001 atatcgaaga gctgcatggt aaatggtcga ctcttaaaga gaaagtgcag atggcaaaag 1494061 aagaagagct tgctgaatcg tctgctattt ctgcgaaaga agcaaagatt gaggatacaa 1494121 gggacaaaat acaagcgctt gatgagtcag tagatgagct ccagcaagtt ttactggtaa 1494181 ctagtgaaga gctggaaaag cttgaaggcc gtaaagaagt cctgaaagaa cgaaagaaaa 1494241 acgctgtgca aaaccaagaa cagcttgaag aagccatcgt tcagttccag caaaaagaaa 1494301 cggttctgaa agaagagctt tcgaagcagg aagctgtctt cgaaacgctt caggctgagg 1494361 tgaagcagtt aagggcgcaa gtaaaagaaa aacagcaggc tctcagtctt cacaatgaaa 1494421 atgtcgaaga gaaaatcgag cagctgaaaa gtgattattt tgagctgtta aacagccagg 1494481 cttcgatacg caacgaactc cagcttcttg atgaccagat gtcccaatcc gctgtcacat 1494541 tgcagagact tgcggacaac aatgaaaagc acctgcagga acggcatgat atttctgcgc 1494601 gtaaagccgc atgtgaaacg gaatttgccc gaattgagca ggagattcac agtcaagtcg 1494661 gtgcatatcg tgatatgcag acaaaatatg agcagaaaaa gcgccaatac gaaaaaaatg 1494721 aatccgctct gtatcaggca taccaatacg ttcagcaagc gagatcaaaa aaggacatgc 1494781 ttgagacgat gcagggagat ttctccggct tttatcaagg tgttaaagaa gtgctgaaag 1494841 cgaaagagcg ccttggcgga attcgcggag cggttcttga gctgatttct acagaacaga 1494901 agtatgaaac ggccattgaa atagcgctcg gcgcttctgc tcaacacgtc gtgaccgacg 1494961 atgaacaatc tgcccgcaaa gcgattcaat atttaaagca gaattccttc ggccgggcga 1495021 cgtttctgcc tctttctgtt attagagacc gccagcttca aagccgtgac gcggaaacag 1495081 ccgcccggca ttcatcattt ctcggggttg ccagtgaact tgtcacattt gatcctgcgt 1495141 atcgaagcgt catccagaat cttcttggaa ccgttctgat cacagaggac ttaaagggtg 1495201 caaacgagct tgcgaagctt ctcgggcacc ggtaccgcat cgtaaccctt gagggagatg 1495261 ttgtgaaccc cggtggttca atgacgggcg gcgcggttaa aaagaaaaat aactccctcc 1495321 ttggaagaag ccgggagcta gaagatgtga cgaaacggct cgctgaaatg gaagagaaaa 1495381 cggcactgct tgaacaagag gtcaaaaccc ttaagcactc cattcaggat atggagaaaa 1495441 aactggctga cttaagagaa accggggaag gcttaaggtt aaagcagcag gatgtgaaag 1495501 gccagctgta cgaacttcaa gttgccgaga aaaatatcaa tacccattta gagctctatg 1495561 atcaagaaaa atctgctctg tcagaaagcg atgaagagag aaaagtgcgc aaacgcaagc 1495621 ttgaagaaga gctctctgcc gtatctgaaa agatgaaaca gcttgaagag gacatagaca 1495681 gactgacaaa acaaaaacaa acgcaatcct caacgaaaga gtctctctcc aacgagctga 1495741 ctgagctgaa gatcgcagcg gccaaaaaag agcaggcttg caagggggaa gaggacaacc 1495801 ttgccagatt aaagaaagag ctcactgaaa cagagcttgc gttaaaagaa gcaaaagaag 1495861 acttaagctt cttaacgtca gagatgtcat ctagcaccag cggcgaagaa aagctggaag 1495921 aagcagcaaa acataaattg aatgacaaaa cgaaaacgat cgaactgatt gcattaaggc 1495981 gcgatcagcg catcaagctt cagcatgggc ttgatacgta tgagcgtgag ctgaaagaaa 1496041 tgaaacgcct gtataaacaa aaaacaacgc tcttaaaaga cgaagaagtc aaacttggac 1496101 gaatggaagt cgagcttgat aatttactcc aatacttacg ggaggaatac agcttgtcct 1496161 ttgagggggc aaaagagaaa tatcagcttg aaactgatcc agaggaagcc agaaagcgcg 1496221 tgaagctgat taaactcgca attgaagagc tgggtaccgt gaacctcgga agcatagatg 1496281 agtttgagag ggtcaacgaa cggtacaagt ttctgtcgga acaaaaagaa gatttaacag 1496341 aagcgaaaaa taccttgttc caagtgattg aagaaatgga tgaagaaatg acgaagcgct 1496401 ttaacgacac attcgtccaa atccgctcac actttgatca agttttccgc tccttattcg 1496461 gaggagggcg agctgaactg aggctcaccg atcctaacga tctgcttcat tcaggagtcg 1496521 agattatcgc tcagccgccg gggaaaaagc tgcaaaactt aaacctcctg tcaggcggag 1496581 agcgtgcgct tactgctata gcgctcttat tctcaatcct aaaggttcgt ccagtgccgt 1496641 tttgcgtcct tgacgaagta gaggctgcgc tcgacgaagc gaatgtgttc cgatttgcgc 1496701 agtatttaaa aaaatacagc agcgatactc agtttattgt gattacccac agaaaaggaa 1496761 cgatggagga agcggatgtg ctttatggcg taaccatgca ggaatccggt gtttccaagg 1496821 taatttcagt taagctggaa gaaacaaaag aattcgttca gtaacgagga aagaggttaa 1496881 aagatgagct tttttaaaaa attaaaagag aaaatcacaa aacagacaga ttccgtatct 1496941 gaaaagttta aggatggcct tgaaaaaaca agaaactcct ttcaaaacaa agtgaatgat 1497001 cttgtatccc gttaccgtaa agtggatgag gatttcttcg aagagcttga agaggttctt 1497061 atcagcgcgg atgtcggttt tacaaccgtt atggaattaa tagatgagct gaaaaaagaa 1497121 gtcaaacgca gaaatattca agatccaaag gaagtccagt cagtgatttc tgagaaactg 1497181 gtcgagattt ataacagcgg agatgagcaa atttcagaac tgaacatcca ggatgggcgt 1497241 ttaaacgtaa tccttctggt aggtgtaaac ggcgtcggga aaacaacaac gatcggaaag 1497301 cttgctcata aaatgaaaca agaaggaaaa tctgttgtac ttgccgccgg agacactttt 1497361 agagcgggag ccattgaaca gctggaagta tggggagagc gtacaggagt gcctgtcatt 1497421 aagcagacgg caggaagcga tccggcggct gtcatctacg atgctgttca tgctgcgaaa 1497481 gcaagaaatg ccgatgtatt aatttgtgat acggcagggc gtctccaaaa caaagtaaat 1497541 ctcatgaaag agcttgaaaa agtaaaacgt gttatcgaaa gagaagttcc tgaagctccg 1497601 catgaggtgc tgcttgccct tgatgccacg accggccaaa atgcaatggc tcaggcaaaa 1497661 gaattctcta aagcaacaaa tgttaccggc attgctttaa cgaagcttga cggtacggca 1497721 aaaggcggta tcgtccttgc gattcgcaac gagcttcaca tcccggttaa actagtcggt 1497781 ttaggagaaa aagttgatga ccttcaggaa tttgatccag aatcctatgt gtacggactc 1497841 ttttcagatt tagtggaaaa agccgacgat taagaaaaag gccccaacat cttggggcct 1497901 ttttcttttt tatcttctta cttgataggc gaaatgataa aggctgttat cagtggatac 1497961 cagtcttgac tcaccagaaa aaactctgaa tgggatgatg tcatagtaat gaacggaaac 1498021 agatgtgtaa tacgtatagt aaccagcagc tggccccaaa tacattggaa cctcaaatgt 1498081 tccgtttgca tcagtcgttc ctgaagcagt ttgtgttgtg tttccgacct tcgtgtccgc 1498141 ttcaaatctt acgggcgcgt ttggcactgg ctgtccgttt tggtcgagta atttgccgct 1498201 tactgtaata ttgtacttga ctcgccaata ttgaccttgt ccgtaattga ttttaccgta 1498261 tacccctcca tctgtgctga tatttgtgat tgaggcctta taaggtgcct cagcagcgtc 1498321 tgcttgctgt gccgggaaac ctattgtaaa cagggctgcc agacataaca taaacaataa 1498381 accgattttt ttcataaaaa tcctccttaa aatagggttc atatacaata tcggaataaa 1498441 ttggatgata tttagcgtat tttggaaaag ttaatcgccg ctttgacaag ataaaaactt 1498501 gacagtgtca ttaaaaccgt gtaaactaag ttatcgtaaa gggatttgac ttaacaaagg 1498561 ggagagctca aatgtcactc gaaaagacaa cgagaatgaa ttatctgttt gatttttatc 1498621 agtcgttgtt gacgtcaaaa cagaagagct atatgtcgct ttattatttg gacgatttct 1498681 ccctaggcga aatagccgaa gaatatgagg tttcaagaca agctgtttat gataacatca 1498741 aacgaacaga agcaatgctt gaacaatatg aagaaaagct gctccttttg aaaaagtttc 1498801 aggagcgtaa agagatgttt aataagctga aggagcttgc ttccggttca aaagaagagg 1498861 aagaaattac agctctgatt gaagcgcttg agaaattaga ttaggaggcg gcaaactatg 1498921 gcatttgaag gattagccga ccgactgcag cagacgattt ctaaaatccg cggaaaaggg 1498981 aaagtcagcg aacaagatgt aaaagagatg atgcgtgagg tccgtcttgc gctgcttgag 1499041 gctgacgtta actttaaagt agtcaaggat tttgtcaaaa aagtaagtga acgcgctgta 1499101 ggccaagacg tcatgaaaag tctgacgccc ggccagcagg tcattaaagt tgttcaagag 1499161 gaactgactg agctgatggg cggcgaagag agcaaaatcg ccgtcgcaaa aaggccgccg 1499221 actgttatta tgatggtcgg tctccaaggt gccggtaaaa cgacaacaag cggtaagctt 1499281 gcgaatctgc tgcgcaaaaa gcataatcgc aaaccgatgc tggttgctgc cgatatttac 1499341 cgcccagccg caattaagca gctggaaaca ctcggcaaac agcttgatat gcctgttttc 1499401 tctcttggcg atcaggtcag tcctgtagaa atagctaaac aggctattga gaaagccaag 1499461 gaagaacatt atgactacgt cattttggat acggcagggc gcttgcatat cgaccatgaa 1499521 ctgatggatg aactgaccaa cgtcaaagaa atcgcgaatc cggaagaaat tttcctggtt 1499581 gtcgattcaa tgaccggtca ggacgctgtg aatgttgcca aaagctttaa tgaacagctc 1499641 ggtttaaccg gtgttgtgtt gactaagctg gatggagaca cacgcggcgg ggctgcgctt 1499701 tctattcgcg ctgtcacaaa cacgccaatt aagtttgcag gtttgggcga aaagcttgat 1499761 gcgttagagc cgttccatcc tgaacgcatg gcatcaagga ttctcggcat gggcgacgtg 1499821 ctgacattga ttgaaaaagc acaggccagc gttgatgaag acaaagccaa agagctggaa 1499881 caaaaaatga gaacgatgag cttcacattg gacgattttc tggagcagct cgggcaagtc 1499941 agaaacatgg ggccgcttga tgagcttctg caaatgatgc cgggtgcagg taaaatgaag 1500001 ggcctgaaaa acatccaagt tgatgaaaaa cagctgaatc atgtggaagc aatcatcaaa 1500061 tcaatgactg ttcttgaaaa agaacagccg gatattatca atgccagccg gcggaagcgg 1500121 attgcaaaag gaagcgggac atccgtacag gaagtcaacc gtctgcttaa gcagtttgat 1500181 gaaatgaaaa aaatgatgaa gcagatgaca aacatgtcaa aaggcaagaa aaaagggttt 1500241 aagctacctt ttatgtaatc ggttatacat gataaaaccg ttgttaagaa aaaacacttt 1500301 acaaacactt ttatcattgt taatatacta tcttgttgaa atattttcgg aggtgctagt 1500361 aaaatggcag taaaaattcg tttaaaacgt atgggagcaa aaaaatctcc tttctatcgt 1500421 attgttgtag cagattctcg ttcaccacgt gacggccgtt tcatcgaaac agtcggaact 1500481 tacaacccgg ttgcaaaacc agcggaagta aaaattgacg aagagcttgc tcttaaatgg 1500541 cttcaaactg gagcgaaacc atctgataca gttcgcaact tgttctctag ccaaggaatc 1500601 atggaaaaat tccacaacgc taaacaaggc aagtaatgac tgatcaacac ttggaagatt 1500661 tgattgtcca cattgtgacg ccgcttgttg atcatccaga tgacattcgc gtcataagag 1500721 aagaaaccga tcaaaagatt gcgctgcgct tatctgtcca taagtcagat accggtaaag 1500781 ttatcggaaa gcaaggccgg actgcaaaag cgattcgaac agctgtattt gcagctggcg 1500841 tacagtcttc taagaaagtt caatttgaaa tatttgacta aaagggagag ggccggcacc 1500901 tccccttttt ttacacgcaa aaaaagggta aactgataga agcttaggca aaatagaaaa 1500961 gcctggacga gtaaaagttt taaaagcggg gagcttggtg cgatgcaaat tattcaccgt 1501021 gtagccgtta tgcaagtctt aaccgagcgc agtaaagaaa agcttttagc ttcttttgct 1501081 gagaagaaac aaatgcttga acgagaatgc agccagctct attttcagct tagaaaacat 1501141 gagaaagaac agcaaaaccc taatatgatt gaacaattta aaaaggcaat agaaaagcga 1501201 aaagatgata taaaaatcat tgattttcaa attgctcaag tacatacatt gccgcttggc 1501261 agtgagttga aagaaaagga agtcgatgcg ctgctgacga ttgaagccgg ggatgactgg 1501321 catgagaaaa cagcagcgaa caccatcgtc ataaaagacg gaaaagtaat tgaaattcgc 1501381 cagaggtgat catatgacaa agcgatggtt taatgtaggc aaaatcgtaa atacccacgg 1501441 aatcaaaggc gaagtgcggg tgatttcaaa aacagatttt gccgaagaac gatacaagcc 1501501 gggaaacacg ctgtatttgt ttatggacgg ccgtaacgaa ccagtggagg taacggtaaa 1501561 cacacataga ctgcataagc aatttcatct cctgcagttt aaagaaagac aaaacctaaa 1501621 tgaagtagaa gagctgaaaa acgcaatcat taaagttcct gaagaagaat taggagagct 1501681 gaatgagggt gaattttatt tccacgaaat tattgggtgt gaagtattta ctgaagaagg 1501741 cgaactcatc ggaaaggtca aagaaatttt gacgcctgga gccaatgacg tttgggtcat 1501801 cggacgaaaa ggaaaaaaag acgcactcat tccttacatt gaatcagtgg ttaaacatat 1501861 cgatgtcagg gaaaagaaaa ttgagattga actcatggaa gggttaatag acgaatgaaa 1501921 atcgattttt tgacgctgtt tcccgaaatg tttgaaggcg tgctcggctc atcgattctt 1501981 caaaaagccc aggaaaaaga tgcggtgcag tttcaagtcg taaatttccg agagtactct 1502041 gataacaagc acaatactgt tgatgattat ccttatggcg gcggggcagg catggttctc 1502101 aagccccagc ctgtttttga cgcggtcgag gacctgacat caaaggcagc cgctgctccg 1502161 cgtattatcc tcgtatgccc gcaaggtgag cgttttaccc aaaaaaaagc cgaacaatta 1502221 gctaaggaag agcatttgct gttcatttgc ggccactatg aaggctatga tgaacgcatt 1502281 cgcgagcact tggtaacgga tgaaatatca attggcgact ttgttctgac gggcggtgag 1502341 ctccctgcaa tgatgatcgc agacagtgtg gtcagactgc ttccgggtgt actgggtaaa 1502401 gaggcttccc atattgagga ttccttcagc accggacttt tagagcaccc gcattataca 1502461 agaccggcag attacaaagg tttaaaagtg cctgaaacac tcttgtcagg aaaccatgca 1502521 aaaattgaag aatggcggaa taaagaatcg atcagaagga cctacctaag acgtccggat 1502581 ctgttgaaag accacccgct tacagagcag caaagaaagt ggatttctga atgggaaaaa 1502641 gaatagattt tattgcatag gctatgaaat tgtgataaga tactacttgt ggcttaagcg 1502701 ggcttatccg ctgcaagctt gaaaacgatg ttccgctgtg ccggtttttg tggccaagag 1502761 catctgttgg aaggagttga aaacgatgca aaaactaatt gaagatatca caaaagaaca 1502821 gcttcgtact gatcttcctg cgttccgtcc tggtgacact ttacgtgtac acgttaaagt 1502881 tgttgagggt aaccgtgagc gtatccagat ctttgaaggt gttgtgatta agcgtcgtgg 1502941 tggtggaatc agcgaaacgt tcacagttcg taagatttct tacggtgttg gcgttgaacg 1503001 tactttccca gtacacacac caaaaatcgc gaaaatcgaa gttgtacgtt acggtaaagt 1503061 acgccgtgct aaactttact acctgcgtga acttcgcgga aaagcggctc gtattaaaga 1503121 gatcagacga taatgataac gaacgaaaag agcttgttac ctgtaacaag ctcttttttt 1503181 atacagaatt tgaaaatgcc ggacaggcat cgtaaaatac ataaaggaca acaatgaatc 1503241 atgcatactg aagataaagg cggtgttcgt gtcacatgac aattcaatgg ttcccgggcc 1503301 atatggcaaa agcaagaagg gaagtaaccg aaaaattaaa attaatcgat atcgtatatg 1503361 aattggtaga tgccagaatt ccaatgtcat caagaaaccc aatgattgaa gatattctaa 1503421 aaaacaagcc gcgaattatg ctgttaaaca aggctgacaa agcagatgcg gcagttacac 1503481 agcagtggaa agagcacttt gagaaccagg ggatccgctc tctgtctatt aattctgtaa 1503541 atggacaagg gttaaatcaa attgtgcctg catcaaaaga gatcctccaa gaaaaatttg 1503601 accggatgcg tgcgaaaggt gtgaagccga gagcgattcg cgctttgatt atcggcattc 1503661 caaacgtcgg aaaatcaacg ctcatcaacc ggcttgcaaa gaaaaacata gcaaaaacgg 1503721 gagacagacc tggtattacg acttctcaac agtgggtcaa agttgggaaa gaattagagc 1503781 tattagatac accgggaatt ttgtggccta aatttgagga tgagcttgtc ggtttgagac 1503841 tggcagtcac cggggctatt aaagactcga ttatcaattt gcaggacgtg gccgtgtttg 1503901 gtcttcgttt tctcgaagaa cattacccag aacggcttaa agagcgttat ggccttgatg 1503961 agatcccaga ggacattgcc gagctgtttg atgcaatagg tgaaaagcgg ggctgtctca 1504021 tgagcggtgg gctcatcaac tacgataaga cgactgaagt catcattcgc gatattcgca 1504081 ctgaaaagtt cggcaggctg tcatttgaac agccgacgat gtaaaggcgc gcagaaatgc 1504141 gggtctttat tttttcttgg ctgaaccgat acatacagta agggagaaga gaaagtgaat 1504201 acattaaccg taaaggacat taaagaccgt ttgcaggaag tgaaggatgc acaagaccca 1504261 tttattgccc aatgcgaaaa cgacccgaga aaaagcgttc aaacgcttgt agagcaatgg 1504321 cttaaaaagc aagcgaaaga aaaagcgctg aaagaacaat gggtgaatat gacttcctat 1504381 gaaaggctgg caagaaacaa aggatttcgc ttgattgcag gtgttgacga ggtcggccgg 1504441 gggccattgg caggaccagt tgtcgccagc gcagtcatcc ttccagagga atgtgaaata 1504501 cttgggctga cagactccaa aaagctttca gagaaaaaac gcgaggaata ttacgagctt 1504561 attatgaagg aagcactggc ggtcgggata ggaattgtag aagctactgt gattgatgag 1504621 atcaatatat atgaagcttc aaaaatggca atggtgaaag cgatacagga tttgtcggat 1504681 acacctgatt atttgcttgt tgacgcaatg acacttccgc tcgacacggc tcaggcgtca 1504741 attataaaag gcgatgccaa aagcgtgtct attgcggcag gtgcgtgtat cgcaaaagtg 1504801 acgagggacc gaatgatgag cgcttatgcc gaaacgtatc ccatgtacgg ctttgaaaaa 1504861 aataaaggct atgggacaaa agaacatttg gaagctctcg ctgcatacgg cccaactgaa 1504921 ttgcaccgca aaactttcgc tcctgttcaa tctttcagat aaatcaccat ggacaaggag 1504981 gcaccttttt aaaatgaaca tacgaaatga tgtgcaaaag gcgctgcagc accttttcgg 1505041 gcgtacagcc gtcccgcagg aaacatcaaa agtaaacgaa gcgctaaacg gggagaagcg 1505101 tctcctctta ggaaaagtgc ttcgtttact aggagatcag catgccctga tccaagtcgg 1505161 caatcaaact gttcagggaa aacttgaaac tcagcttcgt cctcaggcat actattggtt 1505221 ttcctacgaa aaaaaaacgg cagagcaaac aggccgtctt caggtcgttc aaagctttga 1505281 tcaaaatcct aaaaccattc aggatgcagc tggcaaactt ttaaatgcta tttcagtgaa 1505341 gacgtcaaac gcagctctca tgatgacagg agcgatgctg aaaagcaaaa cacccgtaac 1505401 agaaaatgat atcaaaacag ctgtccgctg gatggacacg ctgccttcgc aagacacaaa 1505461 aaaagcagtt gaaacggttc tcttcgcttt aaagcgtgat cttcccattc actccgagat 1505521 tttgaatggt gttcacgctg tgaaatcgcc tgttccgttg catcagcacg tatcccagct 1505581 gctacaggca atcgaccaaa accctcagca gagccaaatg atgtcaaagc taaaggaagc 1505641 agtcacggtg cttttaaata gtgaaatcga tgtccatgca gaacggctga ttgataagct 1505701 tatttcttta accgacaata cgaaagcacc ttctccgacg aatacagctg gaagcaggga 1505761 gcttagcaca ccagctggct cccccggaaa agccagcctg ccgattgcaa atcacacagc 1505821 agaacaggga agcatacaag aagagcctgt taaaacagca gcagacattc caattaaaga 1505881 agcccgccag ctgctggtga agctgacgga atctgctgaa aaaaacagtc tccaaattgt 1505941 gaaagaagca gcaaattgga ttaaagcggc tgcttcatcg ggtgatagta agtcacttgc 1506001 agcttcagct gttttacagg cggcacaagt cacagatcag gaagccgaag tctttttaaa 1506061 ggctgttcag cagacagcac cccatttggc ggataaggca gatgttcttt ctttcttatc 1506121 caaagtgaaa acggcaatcg gcgcaaggga cgaggttgcg ttcattaaag cgtttgaaca 1506181 aggaagcgca gtcacatctg gcgaaatgca atccatcaag ctggctcttt ctgccttaag 1506241 agcatcgcat gaggtagccg aaccagtcaa acaagaagcc gatcagcttt ttcataaatt 1506301 aaatggccag cttttcatgc agcaggacca tccatcatac agccaaattg taatgtcatt 1506361 tccgatgttt tcgaagtcag gggttcagga catgactgtt ctgtttaaag gaaagaaaga 1506421 agcggatgga aagcttgatc cttcccattg ccgccttttg tttttgctgc agcttgatac 1506481 actaaaagaa accgtcgttg attgcttggt acagcaaaaa gtcatgacca ttacaataga 1506541 gactgatttc gagctgcagg ctgcgatcga tccgatggtg cccgcgctta aacaggggct 1506601 aaaggaaatg gggtacagcc tttcaggggt aaacgctaaa aaaagggttc acaccgaaga 1506661 aaaggcttca atcgatcaat atataacaag tatcagtgat caggaagtgg atgtgaaaat 1506721 atgaaagagc agacaccgat cagaaaagct gttgctctcc attatgacga acaaaaagac 1506781 aaggcgccga gagtgattgc cacagggaag ggccatgtag ctgacaacat tataaaagaa 1506841 gcgaaaaaag caggggtccc gattcaagaa gatcggaccc ttgtcgaatt aatgcgccat 1506901 ttgacggtag atgatcaaat tcctgaagct ctttatgaaa cggtagccga gattttttca 1506961 ttcatttaca aattggacga aagcgtaaaa aacaaaaaat agctaaaata ttccccatcc 1507021 ttctttgaaa tttatgtttt taataaagta aaagtttgaa tgtttagaag gattaaaaga 1507081 ttttgcatcg aactgtagac aattcttcca gtattattat agaatgaaag cgcagtctat 1507141 tttagttttg ttacataagt taggaggatg ggaaatgaat atccatgagt accagggaaa 1507201 agaagtcctc agaaaatatg gggtatctgt tcctgaaggt aaagtggctt ttacagcaga 1507261 agaagcagtt gagagtgcaa agagcttatc cagctcggtt tatgtcgtaa aggctcaaat 1507321 tcatgctggc ggtcgaggca aagctggtgg ggtaaaaata gcaaaatcat tagacgaagt 1507381 aaaagcgtat gccgaagaac tattagggaa gaccctagtt acacatcaga cgggtccgga 1507441 cggccaagta ataaaacgct tacttattga agaaggctgc gatattaaaa aagaatatta 1507501 catcggtcta gtgcttgacc gcgccacttc aagaatcgtt ttaatggctt ctgaagaagg 1507561 cggaacggaa attgaagagg ttgcggagaa aacaccagaa aaaatcaaaa aagctgtcat 1507621 tgatccagct gttggccttc aaggctatca agccagagaa attgcattcg ctattaatat 1507681 tccaaaagag ctcgtgggaa aagctgctaa atttatgctt ggactatata aagcgtttgt 1507741 tgagaaagac tgctcaatcg ccgaaatcaa tccgcttgtt gtgactggcg acggaaatgt 1507801 gatggcgctt gatgcaaaat tgaattttga cagcaatgcg ttgtaccgac aaaaggacat 1507861 tatggaatac agagatttgg atgaagaaga tccgaaagaa attgaagcgt ccaaatatga 1507921 tctaagctac atttcccttg atggaaatat cggctgtatg gtaaacggcg cgggacttgc 1507981 aatgtctacg atggatatta tcaagcatta tggaggagaa ccggccaact tccttgatgt 1508041 gggcggcggt gcaaccgcgg aaaaagtcac ggaagcattt aaaatcattc tttctgatca 1508101 aaacgttaaa gggatttttg tcaacatttt cggcggcatt atgaaatgtg atgtcatcgc 1508161 agaaggggtt gttgaagcga ctagacaagt tggtttgaca ttgccgcttg tcgtccgtct 1508221 tgaaggcaca aacgtggatc tagggaagaa aatccttagt gaatcaggat taaacattac 1508281 atctgcggaa tcaatggctg acggcgcgca gaaaatcgta tccttagttt aagaaagaat 1508341 gaaaggcagg ggaccaaata atgagtgttt tcattaataa agatacaaga gttattgtgc 1508401 aagggattac aggttctacc gctttatttc atacgaagca gatgcttgaa tacggcacaa 1508461 atatcgttgg cggtgtaaca cctggaaaag gcggaacaga agcggaaggt gttcctgtat 1508521 ttaatacagt ggctgaagca gttcaaacaa ccggcgctaa cgcgtctgtt atatatgtgc 1508581 ccgcaccgtt tgcagctgat gcgattatgg aagcggtaga tgcggagctt gatctcgtga 1508641 tttgtatcac agaacatatc ccggttttgg atatggtgaa ggtcaaacgc ttcatggaag 1508701 gcaagaaaac gagactgata gggccgaact gtcctggtgt cattacgcct gaagaatgta 1508761 aaatcggcat tatgcccgga tacatccata aaaagggtca tgtaggcgtt gtatcacgtt 1508821 caggaacatt aacatacgaa gcggtgcacc agctctcaga agcgggtgta gggcaatcta 1508881 cagctgttgg aatcggcggc gaccctgtaa atggaacaaa ctttattgac gttttaaaag 1508941 cgtttaacga agatcctgac acacacgcag tcatcatgat tggcgaaatc ggcggtacgg 1509001 ccgaagagga agcggcagag tgggtaaaag ccaacatgac aaaaccggta gtcggtttta 1509061 ttggcggtaa aacagcacct cctgggaagc gcatggggca tgcaggcgcc attatttccg 1509121 gcgggaaagg gacagctgat gaaaaaatca aaacccttaa tgcatgcgga atcgaagttg 1509181 cagagacacc ttctgtcatg ggtgaaacct taatcaaggt gctgaaagag aagaacttgt 1509241 tcgaaacttg taaaacgcat taataaaaaa gggacagccg tcaaggctgt tcctgctttt 1509301 tctaacaaaa ggaggtcaat ctattggatc aggccgctgt ctgcctaacg atttgcagaa 1509361 tcaatcaatt attatcccca tcccttctat taaaatggtg gaaagccgat ccgtctatgt 1509421 cgctgacatc acccgtgtta caaacggtta ctcgtgatca aataaaagca gctgcattaa 1509481 aaaacgaaat agaacaattt tatccaaagc tcccgcgtgt acttgctgct tatcgtgagc 1509541 aaggcattaa caccatccct atttcttcaa agcaatatcc tttctggctt aaaagcattt 1509601 atgatccccc tgccgtactg tttgcaaaag gtgatatgac tcttctttcg aaagggagaa 1509661 aaattggaat tgtaggcaca agaaatccaa cagcttatgg gaaacaagtt gtcaatcatc 1509721 ttacaaaaga gatctgtcgt aaaggttggg tgattgtcag cggactggcg tctgggatag 1509781 acggaatgtc ccatgctgca agtattaagg cgaaggggcg gacaattggc gtcattgcag 1509841 gcggatttca acacatttat ccccgagaaa accttcagtt agcagatcac atggctaaac 1509901 accatatcct gctgtcagag cacccacctg aaactaaacc ccaaaaatgg catttcccta 1509961 tgagaaaccg tattatcagc ggactaagtg aaggcgttat tgtcgttcag ggcaaagaaa 1510021 aaagcggttc gctgattact gcctatcaag cattggaaca agggagagag gtatttgccg 1510081 tacccggttc attgtttgac ccttacgccg gaggtcctat aaaactgatc cagcaggggg 1510141 ctaaagccat atggtcagca gaggatattt tcgaggaact tcctgagaga aacgttcaat 1510201 atacggaacc cttttgaatt atcgtttgac aaacggtatt gtaatattta ataatagtga 1510261 ggatttaaag ttgcatattg ttttctattt aattaatgac gttcatgata aagaatgaaa 1510321 tgttgaaagc caaataaaga cagctgcaaa aataaaattg aaatatcttg aaaagagaga 1510381 gaacacctct tgagggggat gaaaatgtct gattatctag tcatcgtgga atcgcccgct 1510441 aaggcgaaaa cgattgaacg ttacttaggt aaaaaatata aagtaaaagc atcaatggga 1510501 catgtccggg atcttccaaa aagtcaaatg ggagttgaca tagaacagaa ttttgaaccg 1510561 aaatatatta ccattcgagg taaaggcccg gtattaaaag agctgaaaac ggctgcgaaa 1510621 aaagccaaaa aagtgtatct cgcagctgac cccgacagag aaggggaagc gattgcatgg 1510681 catttggcac acagtcttga tttagatctc aactcagact gccgtgtggt gtttaacgaa 1510741 attacaaaag acgctattaa ggaatcgttt aagcatcccc gcatgatcaa tatggattta 1510801 gtggatgcac agcaagcgag acgtatttta gacaggcttg tcggatataa aatcagtcca 1510861 atcttatgga aaaaagtcaa aaaagggctt agcgcaggac gcgtgcaatc cgttgccctc 1510921 cgtttgatta ttgaccgtga aaaagagatt aacgacttta agcctgagga atattggaca 1510981 attgacggta cgttcttaaa aggtcaagaa acctttgaag cgagcttttt cgggaaaaac 1511041 ggcaaaaaac ttcctttaaa tagtgaagct gatgtaaaag agattctttc tcagctcaaa 1511101 gggaatcaat atacagttga aaaagtaacc aaaaaggaac gcaaacgtaa tcctgctttg 1511161 ccttttacca cttctaccct gcagcaggaa gcggctcgca agctcaattt cagagcgaag 1511221 aaaacgatga tgattgcaca gcaattatat gaaggaattg atttaggaag agaaggaacg 1511281 gttggtctga tcacgtatat gagaacggat tcaacccgta tttcaaatac ggctgttgat 1511341 gaagcagctg catttattga tcagacatat ggaaaagagt tcctaggcgg aaaacggaag 1511401 cctgcgaaaa agaatgaaaa tgcccaggat gcccacgaag caattcggcc gacatcagtt 1511461 cttagaaaac caagtgaatt aaaagcagtc ctcggcagag accaaatgag actgtataaa 1511521 ttaatttggg agcgttttgt tgccagccaa atggcaccgg ctgttctcga tacaatgagt 1511581 gtcgacctga caaacaacgg tttgacattt cgtgcaaatg gaagtaaagt caagttttcc 1511641 gggtttatga aggtgtatgt tgaaggaaaa gacgatcaaa tggaagaaaa agaccggatg 1511701 ctgcctgact tacaagaagg cgacacggta ttatcaaaag atatagaacc tgagcagcat 1511761 tttacccagc cgcctccgcg atatactgag gcccggcttg ttaaaaccct tgaagaacgc 1511821 ggtatcggcc gtccatccac atatgctccg acacttgata ctattcagcg gcgcggctac 1511881 gtggcattgg ataataaacg tttcgttccg actgaattag gtcagatcgt tcttgacttg 1511941 atcatggagt ttttccctga gatcattaac gttgagttta cagctaaaat ggagagagat 1512001 cttgatcatg ttgaagaagg aaataccgaa tgggtcaaga ttatcgataa tttctacacc 1512061 gattttgaaa aacgcgtcaa aaaagccgaa tcggaaatga aggaagttga gattgaacca 1512121 gagtatgctg gagaggattg tgaattgtgc agttctccaa tggtatataa aatgggacgg 1512181 tacggtaaat tcttagcttg ctccaacttc cctgactgcc ggaacacgaa accgattgtg 1512241 aaacaaatcg gtgtgaagtg cccgagctgc ggagaaggaa acattgttga gcgaaaatcg 1512301 aaaaagaaac gggtgtttta cggctgtgac cgttatccgg actgtgaatt cgtatcatgg 1512361 gacaaaccaa ttgaacgaaa atgcccgaaa tgcggaaaaa tgctcgtcga gaaaaaactc 1512421 aaaaaaggta tacaagtcca atgcgtggaa tgcgattata aggaagaacc acagaagtag 1512481 cggtgagcag ggtcttgctc accttctttg tgtgttaaaa gaaggccttg aataataaac 1512541 taggagatgt gaaagatgaa ccaacaaaca gtgaatgtaa tcggagccgg actcgcagga 1512601 agtgaagcag catggcagct tgccaaacgt gggattcaag tcaaattgta tgaaatgcgg 1512661 ccagttaaac aaacgcctgc gcatcataca gataaatttg ctgagcttgt ctgcagcaac 1512721 tctcttcgct ctaatacact tgctaacgct gtcggtgtat taaaggaaga aatgcgtgcg 1512781 cttgattcag ccattatcgc tgcggctgac gaatgttcgg tgcctgccgg gggcgctctt 1512841 gcagtagacc gtcatgaatt tgccgcaagt gtgacaaatc gggtgaaaaa tcatccaaac 1512901 gtaaccgtta ttaatgaaga agtgactgaa attcctgaag gccctactat catcgcaacg 1512961 ggtccgttaa catctgaatc gctgtctgcc cagctgaagg agctgactgg agaggactat 1513021 ttatattttt atgacgcagc ggcgccaatt gtagaaaaag acagccttga tatggataaa 1513081 gtgtacctga aatcccgtta tgataaaggt gaagcagcat atttgaactg cccgatgaca 1513141 gaagaagagt ttgaccgttt tcatgaagca ttaacatcag cagaaacagt gccgttaaaa 1513201 gaatttgaaa aagagatttt ctttgaaggc tgcatgccga ttgaagtcat ggcaaaacgg 1513261 ggtaagaaaa caatgctttt cggtccgatg aaaccagttg gtctagagca tcctgttaca 1513321 ggaaaacgcc cttatgccgt cgttcagctc agacaggatg atgctgcggg aacactttat 1513381 aatattgtag gattccagac acatttaaaa tggggagacc aaaaggaagt tctcaagttg 1513441 attccaggac ttgaaaatgt agaaatcgtc agatatggcg tgatgcatag aaacacattt 1513501 attaactctc caagcctgtt aaagccgact tatcaattta aaaaccgcag tgatctgttc 1513561 tttgcaggcc aaatgacggg agtagaagga tatgtggaat cagctgcctc aggacttgta 1513621 gcaggcatta atgcggcgaa gcttgtattg ggagaagagc ttgtgatctt ccctcaggaa 1513681 acagcaattg gcagtatggc acattatatt acaacaacaa accagaagaa cttccagccg 1513741 atgaatgcaa actttgggct tttgaaagaa ttgccagtta aaattaaaaa taaaaaagaa 1513801 cgaaatgaac aatacgcgaa ccgtgcgatt gaaacaattc aaacaatttc gaaaacaata 1513861 taggtattga ttgcaacctg agcgcgattt gtgataccat ttaaaagccc ttcctgggga 1513921 ggtattaggc atggagaatg ttaagaattt cgtaaagtta ttcgttgaat atttacaaat 1513981 tgaaaaaaat tattcacaat atactattgt gaattatgtg gattcaattg aagaattcga 1514041 gactttcctg cgcgttcaag gtataaatgg atttgaagaa gctgcatatc aagatactag 1514101 gatttttttg acagaagcct atgaaaaagg tttatcgaga agaacaataa gcaaaaagat 1514161 atctgcatta agaagctttt ataagtttct gatgcgggaa aagcttattg aagaaaatcc 1514221 gtttcagctt gttcatctgc caaaacagga gaaacggata ccgaagtttc tatatcaaaa 1514281 agagcttgag gagctgtttg aagtttcaga tataagccag ccggccggaa tgagggatca 1514341 agcgctgtta gagctgctct atgccactgg aatgagggtc agtgaatgct gttccataac 1514401 tattaacgac gttgatttat ttatggacac tgtgcttgtt cacggtaaag gcaagaagca 1514461 gcgctatatc ccctttgggt cttatgcccg cgaagcgttg aaggtataca tgaatagcgg 1514521 aagacagtgc ttgctgatga aggcaaaaga acctcatgat ctattattcg taaatcaaag 1514581 aggcggaccg cttacagccc gtggcatcag acatatttta agcgggcttg ttcaaaaagc 1514641 gtcaagcact ttacatatcc atccgcatat gcttcgacat acgttcgcca cgcatctgtt 1514701 aaatgaagga gcggatttga gaagcgttca agaactgctc gggcattcca atctgtcttc 1514761 tacacagata tacacgcacg tttcgaagga aatgttgaga aacacatata tgtctcacca 1514821 tccaagagca tttaagaaaa attaaaggag gccctttatg tcatcttttc atgcgaccac 1514881 aatatttgcc gtacagcata aaggacgaag cgctatgtcc ggagacggcc aagtaacatt 1514941 tggtcaggct gttgtcatga aacacacggc acggaaagtg agaaaactgt ttaacggcaa 1515001 agttcttgct ggttttgcgg gatctgttgc agacgctttc actttattcg aaaagtttga 1515061 agctaagctt gaagaatata acggcaactt aaaacgggcg gctgttgagc ttgcaaagga 1515121 atggcgcagt gataaagtgc taagaaagct cgaagccatg ctgattgtta tgaatcagga 1515181 tactttgctt ctcgtatcgg gaacaggcga ggtgatcgaa ccagatgacg gcattctcgc 1515241 gattggatca ggaggcaatt acgctttggc agcgggaaga gcactgaaaa agcatgccgg 1515301 ggaaagcatg tctgcaagtg agattgccag agccgcgtta gaaacagcag gcgaaatttg 1515361 tgtttacacg aacgatcaaa tcatactgga agagcttgaa tagaaaggac ttgaggcgca 1515421 tggaaaaaaa accgttaact cctagacaga ttgtagatcg gttagaccaa tatattgtcg 1515481 gtcagcaaaa tgcgaaaaaa gctgtcgccg tggcattaag aaaccgctat agaagaagtc 1515541 ttctggatga aaagctgaag gacgaggtcg ttccgaaaaa cattttaatg atgggtccta 1515601 ccggcgtcgg gaaaactgaa attgccagac gaatcgctaa gctttcaggt gcgccattta 1515661 tcaaaattga agctactaaa tttaccgaag tcggctatgt aggcagagat gttgaatcaa 1515721 tggtcagaga tcttgtggag acttctgttc ggcttataaa agaagagaaa atgaatgaag 1515781 taaaggaaca ggcagaagaa aatgcaaaca aacgcattgt tcgtctgtta gttcctggga 1515841 agaaaaaaca atctggtgtt aaaaatccgt ttgaaatgtt ttttggaggc agccagccga 1515901 atggtgaaga tgaggcggag agccaggaag aagcaaacat cgaagaaaaa agaaaacgaa 1515961 tggcgcatca gctggcttta ggagagctcg aagactacta tgtaacagta gaagtcgaag 1516021 aacagcagcc ttctatgttt gacatgctgc agggctcggg tatggagcag atgggtatga 1516081 acatgcagga tgcgctgagc ggattaatgc caaagaaaaa gaagcggcgc aaaatgacag 1516141 tcagagaagc cagaaaagtc ctgacgaatg aagaagcaag caaactcatc gatatggatg 1516201 aagtcggcca ggaagctgtt cagagagcag aagagagcgg gattatcttt atcgatgaga 1516261 ttgataaaat cgcaaagaac ggcggtgcat cttcttctgc cgatgtttca agagaaggtg 1516321 ttcagcggga tatccttccg attgttgaag gttctaccgt tgtcacaaaa tatggttctg 1516381 taaaaacaga ccatgtatta tttattgcag caggagcgtt tcatatggcc aaaccgtctg 1516441 atttgattcc tgagctgcag gggcgtttcc cgattcgtgt agaactgaac aaactcacgg 1516501 tagacgactt cgtgagaatt ttggttgagc cggataatgc gctgctgaaa caatatcagg 1516561 cattattgca gacagaaggt atatctcttg aattttctga cgaagctatt cataagattg 1516621 ctgaagttgc ttatcatgtg aaccaggaca cagataatat cggtgcgaga cgccttcata 1516681 caatacttga acgcctatta gaagatttgt cgtttgaagc tccagatgta acgatggaga 1516741 aaataacgat tacaccacag tatgtcgaag aaaagctcgg aacgatagcc aaaaacaaag 1516801 atttaagtca atttatattg tgaaaaattt aatatgagga atgtttagga ggattattta 1516861 tcatggcttt attacaaaaa acaagaatta ttaactccat gctgcaagct gcggcaggga 1516921 aaccggtaaa cttcaaggaa atggcggaga cgctgcggga tgtaattgat tccaatattt 1516981 tcgttgtaag ccgcagaggg aaactccttg ggtattcaat taaccagcaa attgaaaatg 1517041 atcgtatgaa aaaaatgctt gaggatcgtc aattccctga agaatatacg aaaaatctgt 1517101 ttaatgtccc tgaaacatct tctaacttgg atattaatag tgaatatact gctttccctg 1517161 ttgagaacag agacctgttt caagctggtt taacaacaat tgtgccgatc atcggaggcg 1517221 gggaaagatt aggaacactt attctttcgc gtttacaaga tcaattcaat gacgatgact 1517281 taattctagc tgaatacggc gcaacagttg tcggaatgga aatcctaaga gaaaaagcag 1517341 aagaaattga agaggaagca agaagcaaag ctgtcgtaca aatggctatc agctcgcttt 1517401 cttacagtga gcttgaagca attgagcaca tttttgagga gcttgacgga aatgaaggtc 1517461 ttcttgttgc aagtaaaatt gctgaccgtg tcggcattac ccgttctgtt attgtgaacg 1517521 cactcagaaa gctggagagc gccggtgtta tcgagtctag atcattagga atgaaaggta 1517581 cttatatcaa ggtactaaac aacaaattcc taattgaatt agaaaatcta aaatctcatt 1517641 aatcacaaaa agaacccttt ttgagggttc tttttttatt tcaaataaag gaaatcaata 1517701 agctttattt cctgggttga aagtctttct atgtaataat tttaataaat tttgcatttt 1517761 tcttcaaaaa gtttcaaaaa tgccgaaaag aaaggagaaa aaacagaaat tctgctattt 1517821 tcaggcttat atcaaggcga gaaatgtagt tctaacaatc taggacttta tacctagttg 1517881 caaaatagat aattgtgagg acattttttt acacgaactt catagacttt atgcctgtta 1517941 tttcttacaa taagcatata gttttacaat tctcgacaag gatattgagg gtgaaaaaaa 1518001 ctgaaatgga ggtaagtgga tttgagctta ttttctggaa cgatacaaaa tcttgaaaat 1518061 gccttgagca gagcggatat taagcaaaaa gtcataacta ataatatcgc caatatagat 1518121 acaccgaact ataaggcaaa aaaagtctct ttccaaaatt tattagatca agaatcctcg 1518181 cgtcttgaag cgataaaaac agactatcgt catgttgatt tttctgatac tgattcgaat 1518241 tattcaattg ttgcgagcgg agatacatcg tatcagcaaa acggaaacaa tgttgatgtt 1518301 gacaaagaga tgacagaatt ggcgcaaaat caaatcaact atcaagcttt ggttgaaaga 1518361 atgaacggta aatttaattc gctgaagacc gtattaacag gaggaaaatg atgacagctt 1518421 ttcatagctt aaatgtttca gcatcggctt taacagctca gcgagtcaga atggacgttg 1518481 tatcatctaa cttagcaaat atggatacga caagagctaa gcaggtgaat ggagagtggg 1518541 tgccttacag aagaaaaatg gtttcccttc agtcaaaagg tgaatcgttc tcttccattc 1518601 tcaattctca aatgagcgga agcgggaatg ctggaaacgg tgtgaaggtt tcaaaaatta 1518661 cggaggatga ttcggatttt aatcttgtct atgatccgac agaccctgat gcaaacgctg 1518721 aaggatatgt acaaaagcct aatgttgatc cattaaagga aatggttgat cttgtcagca 1518781 gcactagatc atacgaggcg aatgtcacgg cgatgaatgc cacaaaggga atgctgatga 1518841 aggcgttaga aatcggaaag taggcgaact gttaaacaag gtgaaaaaac gatttaatta 1518901 aggtattagg gggataacaa tgcaatcctt gaattatgaa gatcaggtgc tttggacgcg 1518961 ctggaaagag tggaaagatc ctaaagccgg tgacgactta atgcgccgtt acatgccgct 1519021 tgtcacatat catgtaggca gaatttctgt cggactgccg aaatcagtgc ataaagacga 1519081 tcttatgagc cttggtatgc ttggtttata tgatgccctt gaaaaatttg accccagccg 1519141 ggacttaaaa tttgatacct acgcctcgtt tagaattcgc ggcgcaatca tagacgggct 1519201 tcgtaaagaa gattggctgc ccagaacctc gcgcgaaaaa acaaaaaagg ttgaagcagc 1519261 aattgaaaag cttgaacagc ggtatcttcg gaatgtatcg cccgcggaaa ttgcagagga 1519321 actcggaatg acggtacagg atgtcgtgtc aacaatgaat gaaggttttt ttgcaaatct 1519381 gctgtcaatt gatgaaaagc tccatgatca agatgacggg gaaaacattc aagtcatgat 1519441 cagagatgac aaaaatgttc cgcctgaaga aaagattatg aaggatgaac tgattgcaca 1519501 gcttgcggaa aaaattcacg aactctctga aaaagaacag ctggttgtca gtttgttcta 1519561 caaagaggag ttgacactga cagaaatcgg acaagtatta aatctttcta cgtcccgcat 1519621 atctcagatc cattcaaagg cattatttaa attaaagaat ctgctggaaa aagtgataca 1519681 ataatgaatt tcatggttag cgagtgaaaa acatgtcaac actattatgg cttttaagct 1519741 ttatgctcca cggcgttctt ctgtacgctg tcattatcct gtatacgagg ctcgctgcag 1519801 tgaaagaaac agaaaaacag caaaaacaga tacttgaaga gacggaaaac accttggcgg 1519861 catttctgct tgaattaaaa gaagaaaatg agaaactgat agaaaataaa gcttcatctg 1519921 caagtcaatc agatgaagaa tcccaaaagt caggccttca gacctctgaa acatatcaag 1519981 agcgggatcc agtccaagag gcagagaatc ttcctgaaca tattgaaggt ctgattacag 1520041 aggttgaccg tcgggaagag ctcgtaaaca gtgaggtcca atcatttgaa gaccaggtca 1520101 tagaattata tgaacaggga tattcggcaa gtcaaattgc ccagaaaatg aagagcggaa 1520161 agacagaaat cgagctattt ttaaaatttc gctccaaagg tgtaaaggat tcttgattgt 1520221 cggataaagc tgtgttatat tatgtcttgg tgttaaatac acacgcttaa cgatttatgc 1520281 agagggtgct gcaggcggca gttctgtaca aaaatgacct aagcggagga aaaaaaccat 1520341 tatattagga ggaaataaca tgtcagtcat ttctatgaag caattgcttg aagctggtgt 1520401 tcacttcggt caccaaacac gccgttggaa cccaaaaatg aagcgttaca ttttcacgga 1520461 gcgtaacgga atctacatca ttgaccttca aaaaacagtc aaaaaagtag aggaagctta 1520521 caacttcact aaaaatcttg ctgctgaagg cggaaaaatc cttttcgtcg gaacaaaaaa 1520581 acaagctcaa gattctgtta aagaagaagc tcaacgctct ggcatgtact atgtcaacca 1520641 acgctggttg ggcggtacat taacaaactt cgaaacaatc caaaaacgta ttaaacgtct 1520701 taaagacatt gaaaaaatgc aagaaaacgg tacgtttgat gtacttccta aaaaagaagt 1520761 cgttcaattg aaaaaagaat tagagcgtct tgaaaaattc ctaggcggaa ttaaagatat 1520821 gaaggatctt cctgatgcat tattcatcat cgatcctcgc aaagagcgca tcgctgttgc 1520881 ggaagctcgc aaattaaaca tccctatcat cggtatcgta gatactaact gtgatccaga 1520941 tgaaatcgat gttgttatcc cagcgaacga tgacgctatc cgcgctgtta aacttctaac 1521001 ttctaaaatg gcagatgcaa tcttagaagc gaagcaaggc gaagaagaag cggaagttgc 1521061 tgaagaaact gcaccagaaa cagaaacaac aactgcgtaa cctattcaaa aggtgataag 1521121 agggactgcc ttttatcacc ttttttcaag aaaaatgtgt aatatacata ctcttgttta 1521181 aacatataag gaggaataca aatggcaatt actgcacagc aagtaaaaga actgcgtgaa 1521241 aaaactggcg cgggcatgat ggattgtaaa aaagcgttaa ctgaaactga cggagatatg 1521301 gacaaagcaa ttgacctttt aagagaaaaa ggaattgcaa aagcagcgaa aaaagctgac 1521361 cgtatcgcag cagaaggttc tactcttatt aaaactgacg gcaacaaagg cgttatccta 1521421 gaagtaaact ctgaaactga tttcgttgcg aaaaacgaag gttttaaaga gcttcttaac 1521481 actttagctg accaccttct tgcaaacacg ccagctgatg ttgaagaagc aatgggccaa 1521541 aaaatggaaa atggctcaac tgttgaagag tacatcacaa gcgcagttgc taaaatcggt 1521601 gagaaaatca ctcttcgccg ctttacagtt cttacaaaag acgacagctc tgcattcggt 1521661 gcgtaccttc acatgggcgg ccgcatcggt gtattaactg ttctcaacgg tacaactgat 1521721 gaagaaactg cgaaagatat cgcaatgcac gttgctgcag ttaaccctcg ttacatttct 1521781 cgtgatcaag tatctgaaga agaaacaaat catgagcgtc aaatcttaac tcagcaagcc 1521841 ctccaagaag gcaaacctga aaacatcgta gcgaaaatgg ttgaaggccg tctgaacaaa 1521901 ttcttcgaag aaatttgtct attagaccaa gcgttcgtta aaaacccaga tgaaaaagtg 1521961 aaacaagtta ttgcagcgaa aaacgctact gttcaaactt ttgtccgcta tgaagttgga 1522021 gaaggcatcg aaaaacgtca agaaaacttt gctgaagaag taatgaacca agtgaaaaaa 1522081 taatggtgaa aagatttcgc ggctaagtcg cgtcttttca ggcagtatag gggacacatt 1522141 ttgtgttccc tatttttaaa actatattta caaacctttt tttctcttgc ataatagaaa 1522201 acggcaatgt ttacacttgg aggttatcat ggaaaaacca aaatacaaac gtatcgtatt 1522261 aaagcttagc ggggaagcat tggcaggaga acagggaaat ggaattaacc cgactgtcat 1522321 tcaatccatt gcaaagcaag tgaaggaaat cgctgagctt gaagtcgaag tggctgttgt 1522381 tgtaggcggc ggcaacttat ggcgcggaaa aacaggaagt gacctgggca tggaccgcgc 1522441 gactgctgac tatatgggaa tgctggcgac agtaatgaat tcgcttgctc ttcaagacag 1522501 cttggaaaca ctcggaatcc agtccagagt gcaaacatcc attgaaatga gacaagttgc 1522561 tgaaccgtac ataagaagaa aagcgatacg ccacttagag aaaaaacgtg tcgttatttt 1522621 cgctgcgggc acaggaaacc catatttctc aactgatacg acagctgcac tgcgggctgc 1522681 tgaaattgag gcagacgtta ttttaatggc taaaaataac gttgacggtg tgtataatgc 1522741 tgatcctaga aaagatgaat cagctgttaa gtatgaatca ctttcttatc ttgacgttct 1522801 taaagacggc ctggaagtca tggattcaac agcttcctct ttatgcatgg acaatgacat 1522861 tccgcttatc gtcttttcta ttatggaaga aggaaatatc aaacgtgccg ttatcggtga 1522921 atcaatcgga acgatcgtga gggggaaata acgtgtcaaa agaagtatta actcaaacaa 1522981 aagaaaaaat ggaaaaagca attgctgctt atcagcgcga attggctact gtacgcgcag 1523041 gccgtgcaaa tccatcatta ttagataaag taacggttga atattacgga gcgcagacac 1523101 ctttaaatca gttgtcttct attaacgtgc ctgaagctcg tatgctcgtt atcacgccat 1523161 acgataaaac agcaatcggt gatatcgaaa aagcgatttt aaaagctgat ttaggtctta 1523221 caccaacaag tgacggcaat atgattcgaa ttgcaattcc ggcactaaca gaagagagac 1523281 ggaaagaatt agtgaaagtt gtaaaaaaat atgctgaaga agcaaaagta gctgttcgta 1523341 acgttcgccg tgatgctaac gatgatctca aaaaacttga gaaaaacgga gacattactg 1523401 aggatgaact gcgtgcttcc actgaagacg ttcaaaaact gacagatgaa tatgtgtcaa 1523461 aaattgacag tgtcacaaaa gacaaagaaa aagaaatcat ggaagtttaa tgaaaaacta 1523521 tgtacaatag ataatagtga aaagaccctc tcatgtttac agggggtttt tttgttaata 1523581 ctgttgatta cattgattat cagcagggaa tgtaaccttt ttgggtgacg gaggaatctc 1523641 atgctcaaca tactcaaaaa ttggaagaat cagcaaactg cggcttccaa cttagaacgt 1523701 tatacaaaag aagacatact taagggagaa attcccgaac acatcgccat tatcatggat 1523761 ggaaatggcc gttgggctaa aaaacgctct cttcccagaa ttgcaggcca ccatgaaggg 1523821 atgaaggtgg taaaaaggac cacgaagctc gcaaacgaat taggtgtcaa agtactgaca 1523881 ttgtatgcat tttcaacaga aaactggaaa agaccgaaaa tggaggtcga ttttttaatg 1523941 aagcttccgg aagaattttt gaatacgtat cttccagagc ttgttgagga aaatgtacag 1524001 gttcggatca ttggggatga aacggctttg ccggcgcaca cattacgtgc gattgaaaaa 1524061 gctgtacagg acacggcgca aaacgacgga atgatcctta attttgctct taactatgga 1524121 ggccgtactg aaattgtcag tgctgcaaaa tcactcgcgg aaaaagtgaa ggaaggctct 1524181 ttgaatattg aagacattga tgaatcgctt ttttctactt atttgatgac tgaatctttg 1524241 caggatcctg aacttttaat tcgaacgagc ggcgagataa ggctgagtaa ttttatgcta 1524301 tggcaggttg cctacagtga atttgtcttt actgacgtct tgtggcctga ctttaaagaa 1524361 gatcacttct tgcaggcgtt aggagagttt cagcagagag gccggaggtt tggcggaatt 1524421 tagaggatgg tggacatgaa acaaagaatt ttgacaggtg ttctggcagc aattgtattt 1524481 ttatttttgg ttattgtcgg gaaattgccg ttcaccatat taatttatgc tatgggcagt 1524541 gtggcgcttt ttgaactttt acggatgaaa aagctgaagc tggtttcact gccgggtttg 1524601 atcggtcttt tattattgtg gatgttctta ttaccaagcc agtattcgtt ttttgaagcg 1524661 gacgggattt ccaaaatgga aatcgcttta tttgcggtac tgctattgct gacttacaca 1524721 gtgttggtca agaacacctt tacttttgat gaagtcgggt ttattacgct tgcagcaatt 1524781 tacatcggaa tgtgttttca ttattttatc gaaatcagaa atcttgacca atacggatta 1524841 acatacattt tttatgcgtg tgttgtcatt tggtccaccg attccggtgc ctattttgtc 1524901 ggtaaatcgc ttgggaagcg gaaactgtgg cctgaaatca gtccgaataa aacagtggaa 1524961 gggtttgcag gcggaattgt catcgcactt gtattggcga cgatttttca gcttgttgca 1525021 caacttccga tcccgtatat ctatctgctg ttgatcacgc tgtttttgtc tgtttttgga 1525081 caactgggag atttagtgga atccgccttg aaaagacatt acgatgtaaa ggattctggg 1525141 aatattcttc ccgggcatgg cggtatatta gaccgttttg acagtttctt gtttgtcatg 1525201 cctttcttgt actttctgct tgcccttttt tcataaaaaa gtctaatatg aatatgagac 1525261 tgatcatgca gcaataagaa taggagtagt ggcaactttg aaaaatattt gtcttttagg 1525321 agcaacagga tcaatcggcg aacagactct tgatgtactg cgtgcacatc aagaccaatt 1525381 tcagctggta tctatgtcgt ttggcagaaa tattgataag gccgttccaa tgattgaggt 1525441 ctttcagccg aagtttgtct ctgtcggtga tctggataca tatcataaat taaaacaaat 1525501 gtctttttct tttgaatgcc aaatcgggct gggagaagaa ggactgatag aagcagcagt 1525561 gatggaggag gttgacattg ttgtcaacgc tttgcttgga agcgtcggtc ttatcccgac 1525621 attaaaggca attgaacaga aaaaaacaat tgcgcttgca aataaggaaa ctcttgtcac 1525681 tgcagggcat atagtaaaag aacatgctaa gaaatatgat gttccgctgc tgcctgttga 1525741 cagtgagcat tcagccattt ttcaagctct tcaaggcgaa caggctaaaa acattgaacg 1525801 cctcatcatt acggcatccg gcggaagttt tcgggacaag acgcgggagg agctcgaatc 1525861 agtaacggtt gaagatgcat taaaacatcc aaactggtca atgggtgcaa aaattacaat 1525921 tgattcggct acaatgatga ataagggatt agaggtgatc gaggcacact ggcttttcga 1525981 tataccttat gaacaaattg atgtggtttt acataaggag agcatcatcc attcaatggt 1526041 tgagttccat gataaaagtg tgatcgcaca gctcggaact ccggatatga gagtccccat 1526101 tcaatatgcg ctcacttatc ctgaccgatt gccattacca gatgcgaaaa ggcttgaatt 1526161 atgggaaatc ggcagccttc attttgagaa agctgatttt gacaggttcc gatgcttaca 1526221 atttgctttt gaatcaggta aaataggagg aacaatgccg acagtgctaa atgcggcaaa 1526281 cgaagtagct gtcgctgcct ttttagctgg caagataccg tttttggcta ttgaagactg 1526341 tatcgaaaag gcactaaccc gccatcaatt actgaaaaaa ccgagcctgg cggacattca 1526401 agaagtggac aaagataccc ggggatacgt caattcaata ctcacataag gtggtatgtt 1526461 cgtgaataca gttatagcgt ttatcattat tttcggaacg ctcgttttct tccatgaact 1526521 gggccattta ttgctagccc aaagagcggg aattctctgc cgtgaatttg cgatcggctt 1526581 cggtccaaag attttttctt tcaaaaaaaa tgaaacagtt tatacgatca ggctgcttcc 1526641 ggtcggcgga tttgttcgta tggccggcga agatccggaa atgattgagg tgaaacccgg 1526701 atacacggtc gggcttctgt ttaataagga agatcaagtt gagaaagtca tcatcaatca 1526761 aaaggaaaaa tatccggatg ctttagtcat tgaagtggaa acagcggatc tagagcatga 1526821 catgaagatc accggttatg aacaggggaa agaggacgaa ctttccagct ttactgtcag 1526881 cgaaacatcc ttttttattg tagacggaga agaagtgcag attgcgccgt ataatcgcca 1526941 atttggttcc aaacctgtat ggcagcggat taaagcaatt gctgcagggc cgattatgaa 1527001 ctttatttta gcttacgtca ttttagtgat gcttgggctg attcaaggcg taccgtcaaa 1527061 tgaacctatg ctcgggcagc tgacagacaa tggacgggcg gctgaagcag ggctaaaaga 1527121 aggggattat atccaaagca ttaacggaga gaaaatgagg tcttggactg acattgtctc 1527181 cgctgtaaaa gaaaacccgg agaaagaaat ggacgttgca gtaaaaagag ataacaaaac 1527241 gcttcatatt tcggtgactc cggaagctgt taaagatgag aacaaaaaaa caatcggacg 1527301 tttcggttcc tatgcgccga ctgaaaaagg cgtactctca gcggttgctt acggcgcgac 1527361 atcaacagtt gatgtcacca aagccatttt aaccaatctg agcaaattag taacaggcca 1527421 atttaaactc gatatgctgt caggtcctgt cggcatatat gacatgacag accaagtggc 1527481 gaaaacaggg atcgtgaact tatttcagtt tgcggcgttt ttaagcatta accttgggat 1527541 tgtcaacctg cttccgattc cggcacttga cggaggaaga ctgttgtttc tatttattga 1527601 agcgattcgg ggcaaaccga ttaacaggga aaaagaagca tttgttgtgt ttatcggagt 1527661 agctttctta atgcttctta tgctggttgt cacatggaac gatatccagc ggctgttttt 1527721 gtaaacgaaa agtaaatcaa tcagaggtgc gaagaaatga gacaaagctt gacgcttatt 1527781 cctacgctcc gtgaagttcc agctgatgcc gaagcaaaaa gtcatcagct tcttctgaga 1527841 gcaggattta tcagacagaa tacgagcggg gtatacagct atatgcctct tgcgtataag 1527901 gtgattcaaa acattcagca gattgttcga gaggaaatgg agaaaattga tgccgtagaa 1527961 atgctcatgc ccgcattgca gcaggcagag acatggcagg aatcaggcag atggtatacg 1528021 tatggtcccg aactgatgag actaaaagac cgtcatggcc gtgaatttgc tttaggggca 1528081 acgcatgaag aggttatcac ttcgcttgtt cgcgatgagg ttaaatctta taagcgtctc 1528141 cctctgactc tttatcaaat tcagtctaag ttcagagatg aaaaacgtcc tcgcttcggt 1528201 ttgttaagag gccgcgaatt tattatgaag gatgcgtact ctttccatgc atctgcagag 1528261 agcctggatg aaacgtatca aaaaatgtac gaggcctatt ctaatatttt tgcccgctgc 1528321 ggcattaatg taagacctgt tatcgctgat tcaggcgcaa tgggaggaaa ggatacgcac 1528381 gaatttatgg cactttctgc gatcggagag gatacgattg cgtattctga tgaatcacag 1528441 tacgcggcta atatcgagat ggctgaagtt cttcaccagg aagttccttc agatgaagag 1528501 cctaaagctc tagagaaggt tcatacgcct aacgtgaaaa caatcgaaga actgactgcg 1528561 ttcttacagg tttcggctga agcgtgcatt aagtcagtat tgtttaaagc tgatgaccgt 1528621 tttgtcttag tgcttgtaag aggggatcat gaagttaacg atattaaagt gaaaaacttg 1528681 cttcatgcag aagttgtaga gcttgctaca catgaagagg tcattcagca gctcggaaca 1528741 gagccaggct ttgtaggccc tgtcggtatt catcaggatg tggaagtata tgccgatcaa 1528801 gctgtgaaag caatggttaa tgctgttgcc ggggcaaatg aaggagatca tcattataaa 1528861 aatgtcaatg tgaatcgtga cgcgcaaatt aaagaatttg ctgatcttcg ttttattaaa 1528921 gaaggtgatc cttcaccaga cggcaaggga acgatccgtt ttgctgaggg aatcgaagtc 1528981 ggacaagtct ttaagctcgg aacacgctat tcagaagcga tgaatgcgac atatttagat 1529041 gaaaacggac gcgcgcagcc aatgctgatg ggctgttacg gaatcggtgt gtcaagaacg 1529101 ctttctgcta ttgctgaaca gcatcacgac gaaaaaggct taatatggcc aaaaagcgtt 1529161 gcgccgtacg atcttcatat tcttgctttg aacatgaaaa acgatgggca aagagagctt 1529221 gctgaaaagc tgtatgccga tttaaaagcg gaaggctatg aagtgctcta tgatgaccgt 1529281 gctgagcgtg ccggcgtaaa attcgctgat tcagatttaa tcggccttcc aatccgcatc 1529341 actgtcggaa aacgagctga cgaaggaatc gtcgaagtga aaattcgtca aactggtgag 1529401 tcaactgaga tttcagtaga cgaattatct gcgtttatca gcaagcagta atcaccataa 1529461 cgatttatca aaaaacatgt taaaatagaa ataatagaag gtacctcatt gcctgaggta 1529521 ccttcactta tgatgttttt agggagggat actgtcttaa tggaacagtt atcagtaaac 1529581 agaaggcagt ttcaaattct tctgcagcag attaatatga cagatgatac cttcatgaca 1529641 tactttgaac atggcgagat taaaaagctg acaattcaca aagcttctaa gtcttggcat 1529701 tttcattttc aatttaaatc tttgctgcct tttcaaatat atgacacatt aacaacgagg 1529761 ctgacgcaat cgtttgccca catagcaaaa gtgacatctt caattgaagt tcaggatgcc 1529821 gaggtcagtg aaagtatcgt tcaagactac tggtcacgct gcattgaaga actgcagggc 1529881 atttcgccgc cgattatcag tcttttaaac cagcaaaaac cgaagctgaa gggcaataaa 1529941 ctgattgtca aaaccaaaac agatacagaa gcggctgcgc taaagaacaa atacagttcc 1530001 atgattcaag cagaataccg tcaatttggc tttccggatc ttcagcttga tgctgaaata 1530061 tttgtatccg agcaagaagt tcaaaagttt cgggagcaaa agcttgcgga agaccaagag 1530121 cgggctatgc aggccttgat tgaaatggag aagaaagata aagaaagtga tgaagaccaa 1530181 gcaccatctg gtcctcttgt tatcggttat caaattaaag ataacgagga aatccgaaca 1530241 cttgacagca tcatggacga agaacggaga attacggtcc aaggttatgt gtttgatgtg 1530301 gagacgcgcg agctgaagag cgggcgcacg ctgtgtatct tcaaaattac agactataca 1530361 aatagtattt tgatcaaaat gtttgcacgt gaaaaagaag atgcggcgct gatgaagtct 1530421 ctgaaaaaag gaatgtgggt aaaagcacgc ggaagcattc aaaatgatac atttgtcaga 1530481 gaccttgtca tgatcgcaaa tgacgtaaac gaaataaaag caaaaacccg tgaagattca 1530541 gcacctgaag gagaaaaaag agtggaattg catcttcatt ccccaatgag ccaaatggat 1530601 gctgttacgg gtatcggaaa gcttgtcgaa caggcgaaaa aatgggggca tgaggccatc 1530661 gctttgaccg accatgctgt cgttcaatcc ttccctgatg cgtattctgc ggccaaaaag 1530721 catggaatta aaatgattta cgggatggaa gcgaatctcg tggatgatgg cgtgccaatt 1530781 gcttataatg ccgcacatcg tctgctcgaa gaagaaacat atgttgtttt tgacgttgag 1530841 acgacaggat tgtctgctgt atacgatacc attattgagc tggctgcagt aaaagtaaaa 1530901 ggcggagaaa ttattgataa atttgaggcg tttgcgaacc cgcatcgtcc gctttccgcc 1530961 acaatcatag agctgacagg gatcacagat gatatgctac aagacgctcc ggatgtcgta 1531021 gatgtaataa gagatttcag agaatggatt ggcgatgata ttcttgtcgc tcataatgca 1531081 agctttgata tgggattctt aaatgtagcc tataaaaaac ttcttgaagt cgaaaaagct 1531141 aaaaacccag tcattgatac gcttgaactt ggacgttttc tctatccgga atttaagaac 1531201 caccggttga acacactttg taaaaagttt gatatcgagc tcacacagca tcaccgtgcg 1531261 atctatgata ctgaggcaac cgcttatttg cttctgaaaa tgctgaaaga cgcagctgaa 1531321 aaaggtattc agtaccatga tgagttgaat gaaaatatgg gtcagtccaa tgcttatcaa 1531381 agatcaagac cgtatcatgc aacattactt gccgtgaaca gcacgggact taaaaattta 1531441 tttaagcttg tgtcactttc tcatattcat tatttttaca gagtgccgcg tattccgaga 1531501 tctcagcttg agaaatacag ggaagggctt ctgatcggtt ctgcttgtga caggggagag 1531561 gtttttgagg gaatgatgca aaaatcgcct gaagaggtgg aagatatcgc gtcattctat 1531621 gattaccttg aggttcagcc gcctgaagtg tatcgtcact tgctggagct tgaactggtc 1531681 cgtgatgaaa aagcgctgaa agaaattatt gcgaatatca cgaagctggg ggaaaagctt 1531741 aataaaccgg ttgttgctac gggaaatgtt cattacttga atgatgagga taaaatctac 1531801 agaaagattt taatatcctc acaaggcggg gcaaatccgc tgaataggca tgaactgccg 1531861 aaagtgcatt tcagaacgac agacgaaatg cttgaagctt tttctttctt aggtgaagaa 1531921 aaagcgaagg agatcgtagt caccaatacc caaaaggttg cttctttagt tgatgacatc 1531981 aagccgatta aagatgattt atatacgccg aaaatcgaag gcgctgatga agagatcaga 1532041 gaaatgagct atcagcgtgc aagaagcatt tacggggaag agctgcctga aattgtcgaa 1532101 gcgcggattg aaaaagagtt aaagagtatt attggccacg gatttgctgt tatttacttg 1532161 atctctcaca aacttgtaaa acgttcacta gatgacgggt atctcgttgg ttcccgtggt 1532221 tccgtaggat cttcattagt tgcgacactt actgagatta ctgaggtaaa cccgctgccg 1532281 ccgcactatg tttgtcctga gtgccagcat tctgagttct ttaatgacgg ttctgtcggt 1532341 tctggttttg acctgcctga caagacatgc cctcattgcg gaacgccttt gaaaaaagac 1532401 ggccatgata ttccatttga aacgttctta ggatttaaag gggacaaagt acctgatatc 1532461 gatttgaact tctcagggga atatcagccg caagcacaca attacacaaa agtattgttc 1532521 ggagaagaca atgtatatcg tgcgggaaca ataggcacgg tggcagaaaa aacagcctac 1532581 ggttatgtaa aaggctatgc cggagacaac aatcttcata tgcgcggtgc cgaaatagat 1532641 cggctcgtac agggatgcac aggtgtaaaa cgtacaactg gacagcaccc tggcggtatt 1532701 atcgtagttc cggattatat ggatatttat gatttttcac cgatccagtt cccggcagat 1532761 gccacaggtt cagagtggaa aacgactcat tttgatttcc actccatcca tgacaacctg 1532821 ttaaaacttg atattctcgg acacgatgac ccgactgtta ttcggatgct tcaagactta 1532881 agcggaatag atccgaaaac aattccgacg gatgatcctg aagtgatgaa gatcttccag 1532941 ggaaccgaat cactcggtgt gactgaagaa cagattggct gtaaaacggg cactcttgga 1533001 attcctgaat tcggaacccg atttgtccgg cagatgcttg aagatacaaa gccgaccact 1533061 ttttctgagc tcgttcagat ttcaggcttg tctcacggaa ctgatgtatg gcttggcaat 1533121 gcacaggagc tcatccacaa taatatttgt gagctgagtg aggttatcgg ctgccgtgat 1533181 gacattatgg tttatttaat ctatcaaggc cttgagccgt cccttgcctt taaaatcatg 1533241 gaattcgtgc gtaaaggaaa aggattaacg cctgaatggg aagaagaaat gaaaaataac 1533301 aatgtcccag actggtatat tgattcctgt aaaaagatta aatacatgtt cccgaaagcc 1533361 cacgccgcgg catatgtctt aatggcagtc cgcattgctt actttaaagt gcatcatgct 1533421 cttttgtatt atgcggctta ttttaccgtt cgtgcagatg actttgatat tgatacaatg 1533481 atcaagggct ctacagcaat cagagcggta atggaggata taaacgctaa aggacttgat 1533541 gcttcaccga aggaaaagaa ccttctgact gttttagaat tagcgcttga gatgtgtgag 1533601 agaggctatt cattccaaaa agtcgattta tatcgctcca gcgccacaga gtttattatt 1533661 gacggcaaca gtcttattcc gccgtttaac tctattccag ggttagggac gaacgctgct 1533721 ttgaacattg taaaagctcg cgaagaaggc gaattcctct caaaagaaga tttgcaaaag 1533781 agagggaaag tatcaaaaac gattttagag tacttagatc gccatggctg tctggagtca 1533841 ctgcctgatc aaaaccaatt gtcactgttc taatatggaa agcagaattt ctcagaaatt 1533901 ctgcttctat gcatacataa gcgcaaaaag tgccatcgta atattagagt ttctgtcact 1533961 tgcttaggta tgaaggtaag cgtatatcca tttgcaataa aaatatggtt atggtatagt 1534021 tttattggaa atgctaacga ttaccgaggc aaagagtggg gaaacccgct cttttgtatt 1534081 gaacaggaga attttgtctc gacatgttca tcgtttactt tttagcccct gctcttttga 1534141 agcagggttt ttatgcagag tgacgagacg aatatgagat cgacagcaca aggaggaaga 1534201 acatgagcaa aaaagtgact gacaccgttc aagaaatggc tcagccaatc gtagacagcc 1534261 ttcagctgga actcgttgac attgaatttg tcaaagaggg ccaaagctgg ttccttcgcg 1534321 tgtttattga ttccgatgac ggtgtggata ttgaggaatg tgccaaagta agcgaagctt 1534381 taagcgaaaa gcttgatgag gcagacccaa tcagccaaaa ttactttctt gaagtctcat 1534441 ctccaggagc tgagcgtccg ctaaagaaaa aagccgattt cgaaaaatca ctaggaaaaa 1534501 acgtatacat taagacgtat gagcctattg acggcgtaaa agtgtttgaa ggtgaactgg 1534561 ctgaatttga tggacaaaca gtgacagttg agatcacgat caaaacaaga aagaaacgga 1534621 tcaatattcc gtatgaaaag atagctaatg caagattagc tgttacattc taatgaatac 1534681 aaatgtttta aggggggaga ccgttaaatg agcagtgaat tattagatgc tctcacgatt 1534741 cttgaaaaag aaaaaggcat cagtaaagaa attatcatcg aagcaatcga agctgcgtta 1534801 atttctgctt ataagcggaa ttttaatcaa gcgcaaaatg tacgggtgga tctaaaccgt 1534861 gaaactggct ccatccgtgt atttgcaaga aaagatgtcg ttgacgaagt atacgaccag 1534921 agattagaaa tctcaattga agaggcacag ggcatccatc cggaatatat ggtcggcgat 1534981 gtcgtcgaaa tcgaagttac acctaaggat ttcgggcgca tagctgctca aacagcgaag 1535041 caggtcgtca cacagcgtgt gcgcgaagct gagcgcggtg tgatttattc tgaatttatc 1535101 gaccgtgaag aagacatcat gacagggatc gtccagcgtc tggacaataa atttatctac 1535161 gtgtctttag gcaaaataga agccttgctg ccggttaatg agcaaatgcc gaatgaaagc 1535221 tacaagcccc atgaccgcat taaggtatat atcacaaaag tagaaaaaac aacgaagggt 1535281 ccgcagattt atgtgtcaag aacacatcca ggcctgttaa agcgtttgtt tgaaattgaa 1535341 gtgcctgaaa tttatgatgg aactgtcgag ctaaaatctg ttgccagaga agccggcgac 1535401 cgttcgaaaa tttctgttcg cacagatgat cctgacgttg atcctgtcgg ttcatgcgta 1535461 gggcctaaag gccagcgtgt gcaagcaatc gtcaatgaat taaaaggtga aaaaattgac 1535521 attgtcaact ggtccagtga tcctgtagaa tttgtcgcga atgcgctcag cccttccaaa 1535581 gtgcttgatg tcattgttaa tgaagaagaa aaagcgacaa ctgttattgt tcctgattac 1535641 cagctgtctc tggcaattgg aaaaagagga caaaacgcac gcttagctgc taaactgaca 1535701 ggctggaaga ttgatattaa gagcgaaacg gacgcaagag aacttggaat ctatccgaga 1535761 gaacttgaag aagatgatga gccgctcttt acggagcctg aaactgctga atcggatgaa 1535821 taagaggtga ctttaggtga ataaacacaa aaagatccca ttacgcaaat gtgtagtgac 1535881 tggtgaaatg aagcctaaaa aggaactgat ccgagttgta cggtcgaaag aaggcgaaat 1535941 ctcagtagac ccgaccggaa aaaagaatgg gcggggtgct tatttaacgc tggataaaga 1536001 gtgcatctta gcagcaaaaa agaaaaacac tttgcaaaat caatttcaat cacaaatcga 1536061 tgaccagatt ttcgatgaat tgctggaact ggcggaaaag gtgaaaaaat aaaatgtctg 1536121 gaatggaatg gtttcccttg ctgggtctgg ccaatcgagc tcgtaaggtc gtgtcaggcg 1536181 aagacttggt aataaaagaa atcaggaatg cgcgtgcaaa gcttgtcctg cttacagagg 1536241 atgcatcatc taacacagca aaaaaagtaa ctgacaagtg caattattat aaagtccctt 1536301 ataaaaaagt cgagagtcgc gcggttcttg gacgctctat cggtaaagaa gcccgtgtcg 1536361 ttgtcgccgt cactgaccaa ggttttgcga ataagctgat cagcttgctc gattaatatt 1536421 tttgggggtg aacgaatggc taaaatgaga gtatacgaat atgcaaaagc gttaaatgtt 1536481 tcaagtaagg aaattttgac cgcactgaag aacatggatt tagaagtgaa taatcacatg 1536541 gccatgcttg aagaaaaggc cattaaaaag ctagatgcca aatataaaaa aggcggcgca 1536601 gctgctaaat ctcaaaagcc agcagaaacg aacaaaaaca aacagccaca aggggttaat 1536661 cagcaatcag ctggaaatca accaaataaa attcgagacg gaaagaagaa tgacgtgcag 1536721 aataatcaat ttaacaaaaa caagaagaat aacaacaaca aaaaaaataa acgcaacaac 1536781 aacaataata aaaaccaaca tcagcaaaag cctgtaaagc cgaaaaaaga gcttcctgag 1536841 aaaattacat tctctggcac tttaacagtt ggcgcacttg ctgaagagct tggcaaagag 1536901 ccttcagaac tcattaaaaa gctgatgctt cttggcgtaa tggcaaccat taaccaagag 1536961 cttgataaag acacaatcga actcattgca tcagaatatg gtgttgaaac agaagaggtc 1537021 attgtgcttg aagaaacaga gctggaaaaa tacgaagagc ctgataatga agaggatctt 1537081 gaaattcgtc ctcctgtcgt gacaatcatg ggccacgttg accatgggaa aacaacgctt 1537141 cttgacagca tccgtaaaac aaaggttgtt gaaggggaag caggcggaat cactcagcat 1537201 atcggcgctt atcaaattga agagaacggc aagaaaatca cgttcttgga tacaccgggc 1537261 cacgccgcat ttacaacaat gcgcgcacgc ggtgcagaag taactgatat tacgattctt 1537321 gtcgtagctg ccgatgacgg tgtcatgccg caaacagttg aagcgattaa ccatgcaaaa 1537381 gcagcagagg ttccaatcat cgttgctgtg aataaaatag ataaagaatc cgcaaaccct 1537441 gaccgtgtaa tgcaagaact gacggaatac ggacttgtcc ctgaagcttg gggcggagaa 1537501 accatttttg tgccgctttc cgctttaact ggaaaaggca ttgatgagct cgttgaaatg 1537561 attttgcttg tcagtgaggt agaggaactg aaagcgaatc cgaatcgtca ggcaaaagga 1537621 acggttattg aagctgaact cgataaaggc agagggtcag tcgcgacgtt gctcgtacag 1537681 actggaacac tgcatgtcgg tgatccgatc gtagtcggca atacatttgg ccgtgtccgt 1537741 gcaatggtca acgacattgg ccgccgtgtg aaaactgccg gcccgtcaac tccggttgaa 1537801 attaccggtt tgaatgatgt ccctcaagcg ggagaccaat tccttgtctt taaggatgaa 1537861 aaaacagctc gttctgtcgg tgaagcccgt gcttcgaaac agcttgaaga gcagcgcagc 1537921 gataaagcga agctcagtct tgatgattta tttgagcaaa ttaagcaagg tgatgtaaaa 1537981 gacatcaacc tcatcgtaaa agctgacgtt caaggatctg ctgaagcttt aacggctgca 1538041 cttcaaaaaa ttgaagtaga aggcgttaaa gtgaaaatca tccatacagg cgttggtgcg 1538101 attactgaat cagacattat cttggcatct gcttccaatg caattgttat cgggtttaat 1538161 gtgagaccgg acggaaatgc taagagtacg gctgaagctg aaaatgtaga tattcgactt 1538221 caccgtatca tttacaaagt aatcgacgag attgaagctg ccatgaaagg tatgcttgat 1538281 cctgaatatg aagaaaaagt aattggtcaa gtagaagtac gccaaacatt caaagtatct 1538341 aaaatcggta caattgccgg cggatatgtt actgaaggaa ccattacgcg cgacagcggc 1538401 ctccgtttaa ttcgtgacgg cgtcgtcatc tttgaaggcg aagtagatgt tctgaaacgc 1538461 tttaaagacg atgtgaaaga agtttcacaa ggctatgaat gtggtattac aattaagaaa 1538521 tacaatgaca ttcgtgaagg tgacatcctt gaagcgtttg tcatgcaaga aattgaaaga 1538581 acgtgatcgg atttgcggag tgtgaatgca tcatttatga tgcaggatcg ctaaaagaaa 1538641 agcgtgccgt tctgaagcgg attttaacca gggttcaaaa caagttcaat gtttcgattt 1538701 cggagattgg ctatcaggac acctggcaaa gaaccagctt cggaatcgcc gctgtttctt 1538761 cctctcgcgt tcaaacagaa aaagaactgc agcgcgtcct agcgtttatc gattcttttc 1538821 ctgaaattga acggacgatc actaggacag agtggtttta acttagaggt gattgaattg 1538881 agtatgagag caaaccgtgt cggcgagcaa atgaaaaaag aactcggtga tattatcagc 1538941 cgcaagctga aagacccgag aattggtttt ctgacagtaa cggatgtacg tgtatcaggt 1539001 gatttgcaaa ttgcaaaggt gtatatctcg gttctcggtg acgagaaaaa acgggaagaa 1539061 gcgctgaaag ggctggcaaa agcgaaagga tttatccgat ccgaaatcgg cagccgcatc 1539121 agacttcgaa aaacgcctga aattgaattt gagttcgatg aatcaatcga ttacgggaat 1539181 cggatcgaaa cactgattca cgaattacat tcagagaaac catctgaata aaaaaagaga 1539241 ggataggcgt atatcgtctg tcctctttct tcgtttataa gaaaaaaact caaaagaagg 1539301 agtgaaaggc aaatggttaa cggagttctc cttttacata aacctgttgg catgacatcg 1539361 cacgactgtg tcatgaagat ccgaaagctg ttaaaaacaa aaaaagtagg acatacagga 1539421 acgctcgatc cggaagtatc aggcgtgctt ccgatttgtg taggaagagc gacaaaaata 1539481 gtcgaatact taactgaaaa atctaaaacg tatgatgcag aaataacatt gggcttttca 1539541 accacaacag aggatcaaac cggagaaacg gtggaaacaa agcctgtcaa tcacgacatt 1539601 gataaagcgg atgtagaaaa ggttttaaac agtttaaagg ggaaacaaga acaaattccg 1539661 cccatgtatt ccgctgtaaa agtaaacggc aaaaaattat acgaatacgc aagagcaggg 1539721 attgaagtag aacgtccgaa acgtatgata accattgaag acattgccct gacaacagag 1539781 attaaacatc atggagaaac cgcaagcttc cggtttacag tgacttgctc caaagggacc 1539841 tatgtaagga cgctggcggt catgatcgga gaaaagctcg gatatccggc ccatatgtct 1539901 catttaatcc gtacggcatc cggagatttt tctctcgacg aatgctttac ttttgatgaa 1539961 ctcgaagcac aggcccaatc cggaaccgtg gaagagcata cagttcctat tgaacgtgcg 1540021 ctcaatcatt tgccgaaatg gatcataagt gatacattag ctaagaaagt agaaaatggg 1540081 gctttgcttg agacgcccga gcagttttct gaaatgacaa gtggagaccg tattgccgtc 1540141 tttactgaat ccggaacctg cttggcgatc tatttccctc atcctgcaaa aaaagggctg 1540201 ttaaagccgg caaaagtatt gatgcaaaaa agcgaacaat agaaaaaagg tgaccgttct 1540261 gtgaagacga tacatattac acatcctcat catttaataa aagaggagca ggcaaaatca 1540321 gtgatggcgt taggttattt tgacggcgtt catctcgggc atcaaaaggt aatcggcaca 1540381 gcgaagcaaa tagccgaaga aaaaggtctg acattagctg tgatgacctt tcatccccat 1540441 ccttctcacg tgttgggcag agataaggaa ccaaaggatc tgattacgcc tcttgaagac 1540501 aaaataaacc aaattgaaca attaggcaca gaagttctgt atgtcgttaa atttaatgaa 1540561 gtgtttgctt ctctttctcc taagcagttt atagaccagt atattatcgg ccttaatgtg 1540621 cagcacgcag tggcaggctt tgactttacg tacggcaaat acggcaaggg aacaatgaag 1540681 accatgccgg atgatttaga cggaaaagct gggtgcacaa tggtagaaaa attaacggag 1540741 caggataaaa aaatcagttc ttcgtatatc cgtaccgcgc ttcaaaacgg agatgttgaa 1540801 ttggcgaatg tcttgcttgg acaaccttat tttattaaag gaattgtcat tcatggtgat 1540861 aaaagagggc ggaccatcgg gtttccgaca gcgaatgtcg gtttaaataa cagctatatc 1540921 gttccgccca caggtgtata tgccgtaaaa gcggaagtga acggcgaagt ttacaatggc 1540981 gtttgcaata ttggctataa gccaacgttt tatgaaaagc gccctgaaca gccttccatc 1541041 gaggtcaatc tgtttgattt caatcaagag gtatatggag ccgctataaa aatcgaatgg 1541101 tacaaacgga ttcggagcga gcggaaattc aatggcatca aagaattaac tgagcaaatt 1541161 gagaaagata agcaggaagc catccgttat ttcagcaatt tgcggaaata acttgcaacg 1541221 cacgcaaatt ttattctaaa atatttgcat ataggcacga tttttagtat gatagttttc 1541281 gtagtcttaa aaccattgct tggcaatccg aagtcaccga cggttgctag gtaactgggg 1541341 ctaaatatga tttggaggtg aaacaggatg gcaattactc aagagcgtaa aaaccaactc 1541401 atcaatgagt tcaaaacaca cgaatctgat actggatctc cagaagttca gatcgctatc 1541461 ctaactgact caattaacaa cttgaacgag catttacgta ctcacaagaa agaccaccac 1541521 tcacgtcgcg gtcttcttaa aatggtaggt aagcgtcgta atcttcttac gtatctgcgt 1541581 aataaagacg taactcgtta ccgtgagtta attaacaaac taggcttacg tcgataatcg 1541641 taaaaagcgg gaggattccc gcttttttat cgtattaaag cgaaatttct tataacaaat 1541701 cattgaaatc cttttacata ctactttgac attgatatgt tcaattcatt tcgttcataa 1541761 taggagtaat tgattatttc acacaacgaa gagaggagtt cgtaattgta tgggacaaga 1541821 aaaacatgtc tttaccatag attgggccgg aagaacgctt accgttgaaa ccggccagct 1541881 tgccaaacag gcaaatggtg ctgtgatgat ccgctacggt gatacagcag tacttagtac 1541941 agcaaccgct tcaaaagaac ctaaaccgct tgatttcttc cctcttactg taaactatga 1542001 agaaagatta tatgcggtag ggaaaattcc gggcggattt attaaaagag aaggacgtcc 1542061 aagtgaaaaa gcggttcttg ccagccgttt aattgaccgt ccgatccgtc ctttgtttgc 1542121 cgatggattc cgtaatgaag ttcaagtcat cagcattgtc atgagtgttg accaaaactg 1542181 ctcttcagaa atggctgcca tgttcggttc atctcttgca ctttctgtat cggatattcc 1542241 gtttgaagga ccgattgcag gggttactgt cggacgcatt gatgatcaat ttatcattaa 1542301 cccgacagtc gatcagcttg aaaaaagcga tatcaatctt gtcgttgccg gcacgaaaga 1542361 tgcgattaac atggtagaag cgggagcgga cgaagttcct gaggaaatca tgcttgaggc 1542421 cattatgttc ggccatgaag agattaaacg cctgattgca ttccaagaag aaattgttgc 1542481 agcagtcggc aaagagaaat ctgaaattaa gctctttgaa attgatgaag agcttaatga 1542541 aaaagtaaaa gctttggcag aagaggatct gctgaaagcc atccaagttc atgaaaagca 1542601 tgcccgtgaa gatgccatta acgaagtgaa gaacgcagtt gtggcaaaat tcgaggatga 1542661 agaacatgat gaagacacaa tcaagcaagt gaagcagatt ttatccaagc ttgtgaaaaa 1542721 tgaagttcgc cgcctgatta ctgaagagaa agtaagaccg gacggccgcg gtgtcgatca 1542781 aatccgtccg ctctcttcag aggttggcct cttgccaaga acgcacggtt caggtctatt 1542841 tacaagggga caaactcagg ccctcagcgt atgtacgcta ggtgctctgg gagatgtgca 1542901 aatccttgac ggcttaggtg tcgaagagtc gaaacggttt atgcatcatt acaacttccc 1542961 gcaattcagc gttggggaaa caggaccgat gcgcggaccg ggacgtcgtg aaatcggaca 1543021 cggagcactg ggtgagcgtg cgcttgagcc agttattccg tctgaaaaag acttccctta 1543081 tactgtccgt cttgtttcag aagtgcttga atcaaacggt tctacatctc aagcaagcat 1543141 ttgcgcaagc acacttgcaa tgatggatgc cggtgtaccg attaaagcgc cagttgctgg 1543201 tattgcgatg ggtcttgtca aatcaggcga acattacact gtcttgactg acatccaagg 1543261 catggaagac gcgctcggag atatggactt taaagtagcg ggaactgaaa aaggcgtaac 1543321 ggccctgcaa atggacatta aaattgaagg cctttccaga gagattcttg aagaagcgct 1543381 tcagcaggcg aaaaagggca gaatggaaat cctcaacagc atgcttgcaa cattaagcga 1543441 atcaagaaaa gagctttctc gatatgcgcc taagatctta acaatgacca ttaatcctga 1543501 taaaatccgc gatgtcatcg gaccaagcgg gaaacaaatc aataagatca tcgaagaaac 1543561 cggtgttaaa attgatattg agcaggacgg cacaatcttt atttcctcta cagatgaaag 1543621 cggcaaccaa aaagcgaaaa aaatcatcga agaccttgtg agagaggttg aagtcggcca 1543681 actttaccta ggtaaagtga aacggattga aaaattcggg gctttcgttg aaattttcag 1543741 cggaaaagac ggtttggtgc acatttcaga gcttgcgctt gaacgcgtag ggaaagttga 1543801 agatgttgtg aaaatcggag acgagattct tgtcaaagtc actgaaattg ataaacaagg 1543861 acgagtgaat ttatcccgca aagcggtgct ccgtgaagag aaagaaaaag aagaacaaca 1543921 atcttaaatg aaaacataaa aggagcctgg gagacccggc ttctttattt tgaagctttt 1543981 caaaagcagg cgggttctac cttgtccttc tccttcataa tgtgaggtga gggggggaca 1544041 gaacatgtac aaaaaatttg taccgtttgc cgttttttta tttctttttt ttgtctcatt 1544101 tgagatgatg gaaaatccgc atgcacttga ttatataggg gcaatgaaaa aagatacggt 1544161 gactgtcacg gcgtcaaaag acccgttata tgaagaattg cttcaaaaag cgccggagta 1544221 cgaagttaag ccccagaatg caagaattga taaagtgtgg aaaagcattc caggctacaa 1544281 tggattaaag gtcaatattg aacaatcata taaaaaaatg aaacagcatg gtaagtttcg 1544341 ggaaaaagat ttggtgtaca gtcaagtaaa accaagtgtt catcttgagt cacttcagcc 1544401 tgagcctatt tataaaggaa atcctgacaa accgatggtg gcttttttaa tcaatgtggc 1544461 atggggaaat gagtatttgg aaaaaatgct tcctattctg caaaagcacc aggttaaagc 1544521 tacgttcttt ttagaaggca attgggtgag aaacaatgta cagctcgcta agaagattgc 1544581 aaaagacgga catgaaatcg gaaatcattc atacaatcat ccggatatga gcaaactgac 1544641 tacaggaaga atttccgagc agctcgacaa gactaatgaa caaatagaac aaacgatcgg 1544701 cgttaagcca aagtggttcg ctccgccaag cggaagtttc agaaaagcgg ttatcgacat 1544761 tgcagcagag aaacagatgg gaacagtcat gtggacagtt gatacaatcg attggcaaaa 1544821 gccggctccg tctgtacttc agacgagagt gttaagcaag atacataatg gtgccatgat 1544881 tttaatgcat ccgactgacc ctacggcgga aagtcttgaa gcgctgatta cacagataaa 1544941 agacaaagga tatgcgcttg gaacagtcac tgaactaatg gatgaaacaa gactattgaa 1545001 gtaacagatg aaggcagctt gtctttgaat aggaggaaca aatttgatta aacgatatac 1545061 gtgtcaaaat ggtgtaagaa ttgtgctgga aaataacccg acagtccgtt ctgttgcgat 1545121 cggcgtatgg atcggcacag gttcgagaca tgaaacgccg gagataaacg gaatttctca 1545181 ctttttagag cacatgttct ttaaagggac gagcacaaaa tctgcacgcg agatagcaga 1545241 atcttttgat cgtattggcg gccaggtcaa tgcgtttact tcaaaggaat atacctgcta 1545301 ctatgcaaag gtgcttgacg agcatgcgaa ttacgcgctg gacgtattag cagatatgtt 1545361 ctttcattca acgtttgatg aaaacgagct gaaaaaagag aaaaatgtag tatatgaaga 1545421 aattaaaatg tatgaagatg cgccggacga cattgtacat gatttattga gcaaagccac 1545481 ttacggcaat cattctttag gctacccaat tttaggaacg gaagaaacgc ttgcttcctt 1545541 taacggtgac tctctcagac aatacatgca tgattattat acgccggacc gagtggtgat 1545601 ttcggtagcg ggcaatatat ctgacagttt tatcaaagat gtagaaaaat ggttcgggtc 1545661 atacgaggcg aaaggcaaag cgacaggcct tgagaagcct gagttccaca cggaaaaact 1545721 gacgagaaaa aaagaaacag agcaggctca tttgtgcctt ggatttaaag gcttagaggt 1545781 tggccatgaa cgtatttatg atttaatcgt cctcaacaat gtgctcggag gcagcatgag 1545841 cagccggctg ttccaagatg tgcgtgaaga taaaggactt gcttattctg tttacagcta 1545901 tcacagctca tatgaggaca gcggaatgct aacgatttac ggcggaacgg gtgcaaatca 1545961 gcttcagcag ctgtcggaaa caattcaaga aaccctggcc acattaaaac gtgacggcat 1546021 tacctcgaaa gaactggaaa acagcaaaga gcaaatgaag ggaagcttaa tgctgagctt 1546081 agaaagcaca aacagcaaaa tgagccgaaa cggaaaaaat gaactgctgc tcggcaaaca 1546141 taaaacatta gatgaaatta tcaatgaatt aaacgccgtg aacttagagc gtgttaatgg 1546201 ccttgccaga caattgttta ccgaagacta tgcattagca cttatcagcc cttccggcaa 1546261 tatgccgtct taaaaaggaa agcctgcccc ataatggagc aggcattttt taatcccttt 1546321 catcatacat agtacaaggg ggtgacagac atgcggctca gtgaattatc gggaaaggaa 1546381 attgtagaca tcaaaagagc tgaacggctc ggagtgctcg gccagaccga tttggaaatc 1546441 aatgaacagg atggacagat tacagcactc ctcattccca cagttaagtg gtttggtttg 1546501 agaaagcaag gtcatgacat tcgtgtccca tggcaccata ttcaaaagat cggttcagat 1546561 atgattatat tagatgtacc tgaggaaatg cctcctcgac aagagtaaat agcccaattg 1546621 actgtgaagc gggctctaaa gaaaacatct gaaacatcgg ctgccggagc cgatgttttt 1546681 ttatatggaa aaagcgcatc ttttatattc accggtattt ccttttgatc ataagatgaa 1546741 ggggagctta acaactagag atccagtata tacaaagaag gtgaacgttt agaatgttaa 1546801 ccggattgaa aattgcagtt atcggcggtg acgcaagaca gctcgaaatt ataagaaagc 1546861 tcactgaaca gcaggctgac atctatcttg tcggttttga ccaattggat cacggtttta 1546921 ccggggcagt aaaatgcaat attgatgaaa ttccttttca gcaaatagac agcatcattc 1546981 ttccagtatc cgcgacaaca ggagaaggtg tcgtatcgac tgtattttcg aatgaagaag 1547041 ttgtgttaaa acaggaccat cttgacagaa cgcctgcaca ttgtgtcatt ttctcaggaa 1547101 tttctaacgc ctatttagaa aacattgcag ctcaggcaaa aagaaaactt gttaagctgt 1547161 ttgagcggga tgacattgcg atatacaact ctattccgac agtagaagga acgatcatgc 1547221 tggctattca gcacacggat tatacgatac acggatcaca ggtggccgtt ctcggtctgg 1547281 ggcgcaccgg gatgacgatt gcccgtacat ttgccgcgct cggggcgaat gtaaaagtgg 1547341 gggcaagaag ttcagcgcat ctggcacgta tcactgaaat ggggctcgtt ccttttcata 1547401 ccgatgagct gaaagagcat gtaaaagata tagatatttg cattaatacc ataccgagta 1547461 tgattttaaa tcaaacggta ctttctagca tgacaccaaa aaccttaata ttggatctgg 1547521 cctcacgtcc cgggggaacg gattttaaat atgccgagaa acaagggatt aaagcacttc 1547581 ttgctcccgg gcttccaggg attgtcgctc ctaaaacagc tgggcaaatc cttgcaaacg 1547641 tcttgagcaa gcttttggct gaaatacaag ctgaggaggg gaaataagga tgtcgtcatt 1547701 aaaaggaaaa agaatcgggt ttgggctgac cgggtcgcat tgcacatatg aagcggtttt 1547761 cccgcaaatt gaggagttgg tcaacgaagg agctgaagtc cgtccggttg tcacatttaa 1547821 tgtaaaatct acaaataccc gatttggaga gggcgcagaa tgggttaaaa aaattgaaga 1547881 cctgactgga tatgaggcca ttgattcgat tgtaaaggca gaacctcttg ggccgaagct 1547941 gccccttgac tgcatggtca ttgcgccttt aacaggcaat tcaatgagca agctggcaaa 1548001 tgccatgacg gacagcccgg tgctgatggc ggcaaaagcg acaatccgga acaatcggcc 1548061 tgtcgttctg ggtatctcga caaatgatgc tcttggttta aacggaacaa atttaatgag 1548121 gctcatgtca acaaaaaata tcttttttat tccattcggg caagatgatc catttaaaaa 1548181 accgaattca atggtagcca aaatggatct gcttccgcaa acgattgaaa aggcactcat 1548241 gcaccagcag cttcagccga ttctagttga gaattatcag ggaaatgact aaatttacag 1548301 aaaatctttc ccaaactaaa aaattcggtc atcacccgca tattctatgg taaaataaaa 1548361 cgtaaaatca tagtcaaatc aattcaatga agctgattgg cggaaggagt tttacagatg 1548421 ggaagaggtt tacacgtagc tgttgtcgga gcgacagggg ctgtgggaca acaaatgctt 1548481 aaaacacttg aagacagaaa ctttgaaatg gacacactta cattgctatc ttcaaaacgc 1548541 tctgcgggga caaaagtcac gtttaaaggc caagagctga ctgttcagga agcttctcct 1548601 gagagctttg aaggggtaaa tattgctttg ttcagcgccg gcggaagcgt atcacaagca 1548661 ttggcaccag aagctgtaaa acgcggcgct attgttatag ataatacgag tgcgttccgc 1548721 atggatgaaa atacaccgct tgttgtgcca gaagtgaatg aggcagactt gcatgaacac 1548781 aacggcatta ttgccaatcc aaactgctct acaatccaaa tggttgcggc acttgaaccg 1548841 atccgcaaag catatggctt aaacaaggtc atcgtatcaa cttaccaggc agtatcagga 1548901 gcgggtaatg aagctgtaaa agagctttac agccaaacac aggcgatttt aaataaagaa 1548961 gaaatagagc ctgagatcat gcctgtaaaa ggtgacaaaa aacactatca aatcgccttc 1549021 aacgcgattc cgcaaatcga taaattccaa gataacggct atacgtttga ggaaatgaaa 1549081 atgataaatg aaacgaaaaa aatcatgcac atgcctgacc ttcaagtagc ggctacatgt 1549141 gtgagactgc caatccaaac tgggcactca gagtccgtct acatcgaaat agaccgtgat 1549201 gacgctacag ttgaagatat taaaaatcta ttgaaagaag ctccgggcgt gacacttcag 1549261 gatgatccaa gccagcagct ttatccgatg cctgctgatg ctgtcggcaa aaacgatgtg 1549321 tttgtaggcc gcatccgcaa agacttggac agagcaaacg gttttcattt atgggttgtt 1549381 tctgataacc tattaaaagg cgcggcatgg aactctgttc aaattgcaga aagcctgaaa 1549441 aaactaaacc tcgtataaaa gagagaattt tctaaagacg aatagaagag agtaaggcgc 1549501 tatcagcctg ctctcttctg ttacgtccga ataatttgga gtgaaaacag tgaagataat 1549561 tgttcaaaag ttcggcggaa catcagtaaa agatgataaa ggccgcaaac tggctttagg 1549621 gcatattaaa gaagcaatca gtgaaggata taaggttgtc gttgtcgttt cagcgatggg 1549681 ccgaaaaggg gacccgtatg caacagattc tttgctcggg ctgctttacg gcgatcagtc 1549741 agcgatttct cctagggagc aggatttgct tttatcttgc ggagagacta tttcctctgt 1549801 cgtctttaca agcatgctgc ttgataacgg tgtgaaagca gctgcgctga caggggctca 1549861 ggctggcttt ttaacgaatg atcagcatac taatgcgaaa atcattgaaa tgaaaccgga 1549921 gcgtttattc agtgtgctcg ccaatcatga tgcggtagtc gtcgcaggct tccagggcgc 1549981 aactgaaaag ggtgatacaa caacaatcgg cagagggggc agcgatacgt ctgcagccgc 1550041 actcggagca gctgttgatg cggaatacat cgatattttc accgatgtag aaggcgtgat 1550101 gactgctgac ccaagagtgg tagaaaatgc aaaaccgctt cctgttgtga cgtatacgga 1550161 aatctgcaac ctggcgtatc agggggccaa ggtcatttct ccgcgtgctg tggaaatcgc 1550221 aatgcaggcc aaggttccga tccgcgtccg ttcgacttat tcgaatgata aaggcacatt 1550281 ggtgacatca catcactctt ccaaggtcgg cagtgatgtt tttgaaaggc tgattacggg 1550341 aatcgcccat gtcaaagatg tcacgcagtt caaagtgcct gcgaaaatcg gccagtataa 1550401 cgttcagact gaagtgttca aggctatggc aaacgctgga atcagtgtcg atttctttaa 1550461 cattacacct agtgaaatcg tctatacggt agccggaaat aaaacagaaa cagctcagcg 1550521 tattttaatg gatatgggct atgatccaat ggtgacgaga aactgcgcga aggtatcggc 1550581 ggtcggcgcg ggcattatgg gtgttcccgg tgttacgtcc aaaattgtat cggctctttc 1550641 agaaaaagaa attccgatcc ttcagtcggc tgacagccat acgacgatat gggtgctcgt 1550701 ccatgaagcg gatatggttc ctgctgtaaa cgctttgcat gaagtgtttg aactttcgaa 1550761 gtaaatgtga ttgaatcatg atgaggtgaa taaaatgaat ttcggaaatg tgtctacagc 1550821 gatgattaca ccctttgaca ataaagggaa cgtagacttt caaaaactgt ctacactgat 1550881 tgattacttg ttgaaaaacg gaacggattc tttagtagta gcgggaacaa ctggagaatc 1550941 tccgaccctt tcaactgaag aaaaaattgc gctttttgaa tatacggtaa aagaagtaaa 1551001 cggacgggtg cccgttatcg ctggtactgg gagcaacaac acgaaagatt ccattaagct 1551061 gacaaaaaaa gctgaggaag cgggcgtgga cgctgttatg cttgttaccc cgtattacaa 1551121 taaaccttct caagaaggaa tgtaccagca ttttaaagca attgcggcag agacatctct 1551181 tccggttatg ctctataatg ttcctggccg tacggttgct tctcttgctc ctgaaacgac 1551241 gatccgtttg gcggcagaca ttccgaatgt ggttgcgatt aaagaagcga gcggagacct 1551301 cgaagcgatt acaaaaatta ttgctgaaac acctgaagac ttctatgtct attcagggga 1551361 tgatgctcta acgcttccaa ttctttcagt tggaggtaga ggagttgtgt cagtggcgag 1551421 ccatattgca ggcactgata tgcagcaaat gatcaaaaat tatacgaatg ggcaaacagc 1551481 taatgcggca ctgattcatc agaaactgct gccgattatg aaggaactgt ttaaagcgcc 1551541 taatcctgct ccagtcaaaa cagcgcttca gctgagaggt cttgatgtcg gttctgtgcg 1551601 tctgcctcta gtcccattaa ctgaggatga acgtctgagc ttaagcagca cgatcagcga 1551661 actgtaagaa aatttcatac agtgaaacaa acgcggtcat tctcacattc agctgagttt 1551721 gaccgtttct tttacatatt ggttttccct aaaccttctg ctttatcttg ttttctaaat 1551781 ttactttcag ttataatagg aacaagtgat gatggacggg tatgagacta ggaggatata 1551841 gattttgaaa aagaaaaata cagaaaacgt tagaattatc gcccttggcg gtgtcggaga 1551901 gattgggaag aacctttatg tcattgaaat tgactcagac atatttgtcg ttgatgccgg 1551961 ccttatgcat ccagaaaacg aaatgctcgg tattgatgta gtgattcctg acatatcata 1552021 tttgattgaa cgggctgacc gcgtcaaggc aatcttttta acgcacgggc acgatgaaaa 1552081 tatcggcggc gttttttact tattaaacaa gctgtccgtt ccagtgtacg gaacaaaact 1552141 gacgcttgca ctgttaagag agaaattaaa acaatacgga cataaccgaa aaactgattt 1552201 aagagaaatt cactccaaat ctgtcattac atttgaatca acaaaggtat cgttctttag 1552261 aacgattcac agcattcctg attctgtagg tgtgagcttt aaaacatcac ttggatctat 1552321 tgtatgcacg ggagacttca aatttgacca aacacctgca cttaatcaga cgtgcgacat 1552381 tggcgagatc gccaagatcg gcaatagcgg cgtgctcgct ctgctttctg acagtgcaaa 1552441 tgcggaacgg ccgggttaca ccccttcgga agcggctgtc agcggagaaa tttcggatgc 1552501 gctgtataat tcacagaacc gggtgattat tgctgttttc gcatccaata ttaaccggat 1552561 tcagcaagtc attcatgcag cggctcaaaa tggcagaaag attgccgtag ccggaaaaaa 1552621 tcttcaatct gtcctgcagc tggcgagaaa gttaggatat attgaagcag atgatgaatt 1552681 gtttatttct gtacaggatg tcaaaaaata tccgaagcgc gaagtggcca ttattacagc 1552741 cggaagccaa ggtgaaccat tagctgcttt gacaagaatg gcaaacaaag ctcacaaaca 1552801 gctgaacatt gaagaagggg atacggtggt cattgcgtca actccgattc ccgggcagga 1552861 actcatttac tctaaaacag tagatcttct tgcgagagcc ggtgcacaag tcatctttgc 1552921 ccaaaagcgt gttcatgtat caggccacgg ctcacaagaa gagttaaagc tgatgatcaa 1552981 cctgcttaaa ccaaaatatt tgattcctgt aaacggcgaa tacagaatgc aaaaagctca 1553041 ttcaaaaatc gctgaagaaa ccggcatgaa gcgcagtgac atcttcttaa ttgaaaaagg 1553101 cgacgtcgtt gaattccgcg gccaaaacgt aaaaattggg gataaagttc cttacggcaa 1553161 tattttaatt gatggtttag gtgtcggtga tatcggcaat atcgtattga gagaccgccg 1553221 cttgctttca caggacggaa ttttaatcgt tgtcattaca cttgataaac aaaagaaaca 1553281 tcttgtatca ggaccagaaa ttatcactcg cggctttgtt tatgtaagag agtctgaagg 1553341 tcttatcgta caggctactg agcttgtacg gtccatcgtg acagaagcga ctgaaacatc 1553401 aaatgtcgaa tggtcaacgc tgaagcaggc aatgcgggat gctttgaacc aattccttta 1553461 tgaaaaaacg aaacgtaaac cgatgatcat cccaattatt atggaagtat aatgactgac 1553521 taaagaccgg agctgctccg gtctttattt tttgtccttc aagccgggat tgaatgaagt 1553581 atctttgttc ataatacaaa gagaaactcg gaaaggatga aagcgagatg gatcatcgta 1553641 tggaaaacac agaagaagag cgtcctgaaa aaaatgatgc gaaggacagc attatgaata 1553701 aaatacagca gcttggtgaa acgacgcttc cgcagctgcc ccaagataca aatattcatt 1553761 gtctgaccat tatcggacaa attgaaggcc atgttcagct tcctccgcaa aacaaaacaa 1553821 caaaatatga acatgtcatc ccgcagattg tggcaattga acaaaatccc aaaattgaag 1553881 gcttgctgat catattaaat actgtcggag gagatgttga agctggtctt gccatagcgg 1553941 aaatgcttgc atctttatcg aaaccgaccg tttctatcgt gcttggcggg gggcattcaa 1554001 tcggcgttcc gattgctgta tcctgtgatt acagctatat cgccgaaaca gcaacgatga 1554061 cgattcatcc agttaggctc accgggctgg tcatcggggt gccgcaaacg tttgaatacc 1554121 tggataagat gcaagaaaga gttgttaaat ttgtgacaag ccattccaat ataaccgaag 1554181 agaagtttaa agagctaatg ttttcaaaag gaaacttaac acgcgatatc ggaacaaatg 1554241 tagtcggtaa ggatgcagtt aaatacggat tgatcgatca cgcaggcggt gtcggacagg 1554301 caatcaataa actgaatgag ctcatcgatg aagcaaggaa agaagaagga cggatgattc 1554361 aatgattctt tataccgtga tgcctcagga aattgtgttt gcagaacaga accaagagac 1554421 aagcgcacat gagcaaattg aatataaagg tgtaccgctt ctagtcgaaa tgaaagggaa 1554481 tgaagcggaa gtcattcaaa tcatgagcac caatccaatg cattttctgc atccggacat 1554541 ttcaccggga caaaagctga aattaaacgt ataagaatcc aacccttttt taagggcaaa 1554601 atatgctata ataggggaat cctacagaaa aaacgcagcc tgtaaacggc tgctttcttc 1554661 attatgtatg aacttacatt ttttaacgca gtaaggtgat gagtgtggca aagaaaaaac 1554721 gaaaatcaag aaaaaaacag gcgaaacagc tcaatataaa atacgagctc aacggattgc 1554781 tgtgtatagc catttcaatt atcgcaatct tgcagctggg ggtagtcggg caaacgttta 1554841 tctatttgtt ccgctttttt gctggagagt ggtttatttt atgcttgtta ggtttattgg 1554901 tgttaggagt ctcactgttt tggaagaaaa aaaccccaag ccttttaacg agacgaaagg 1554961 ccgggttgta ctgtattatc gcaagcatat tgctgctttc tcacgtgcag ctatttaaaa 1555021 atttgacgca caaagggtct attgagtctg caagcgtggt gcgcaatacg tgggaattgt 1555081 ttttaatgga catgaatggc agctctgctt cacctgattt aggcggaggg atgatcggtg 1555141 cgctgctgtt tgcggcttca cactttttgt ttgcgtcgac tggttctcag atcatggcaa 1555201 ttgtcatgat tttgatcgga atgattttag taacaggacg ctcgctgcaa gaaacgctaa 1555261 aaaagtggat gagcccgatt ggacgtttta taaaagaaca atggttagca tttattgatg 1555321 acatgaaatc cttcaaatca aatatgcagt catcgaaaaa aacgaaagcg ccgagcaaaa 1555381 aacaaaaacc ggcccgcaaa aaacagcaaa tggaaccgga gcctcctgat gaagaggggg 1555441 attatgaaac agtatcgcct cttattcatt cagagccgat tatctcaagc ttttctgatc 1555501 gtaatgaaga ggaagagtct ccagttatag aaaagcgcgc cgaacctgtg tcgaagccgc 1555561 ttcaggacat ccaaccggag acaggtgatc aggaaactgt ttctgctcct cctatgacct 1555621 ttacagagct cgaaaataag gattacgaga tgccgtcact ggatttgctg gcagatccga 1555681 agcataccgg ccagcaggct gataaaaaga atatttatga aaatgcgaga aagcttgaac 1555741 gcacattcca aagctttggc gtaaaggcga aagtcacaca ggttcatctc ggaccggccg 1555801 taacaaaata tgaagtatat cctgatgtcg gagtgaaggt tagcaaaatt gtcaatttaa 1555861 gcgatgattt agcgcttgcg cttgctgcga aggatatcag gatcgaagcg cctataccag 1555921 gcaaatcagc aatcggaatt gaagttccaa acgcagaagt ggcaatggtt tcgctgaaag 1555981 aagtgctgga gtctaaattg aatgacagac cggatgcgaa gctgttaatt ggactcggcc 1556041 gcaatatttc aggtgaagct gtattggctg agttaaacaa gatgccccac cttttggtcg 1556101 caggcgcaac cggtagcggg aaaagtgtct gtgtcaacgg cattattaca agtattttaa 1556161 tgcgggcgaa accgcatgaa gtgaaaatga tgatgatcga tcctaaaatg gtagagctaa 1556221 atgtctacaa cgggattccg catttgcttg ctcctgttgt aaccgatccg aaaaaagcgt 1556281 cgcaggcttt gaaaaaggtt gtcaatgaaa tggagcggcg gtacgaatta ttttctcata 1556341 cgggtacaag aaatattgaa ggatacaatg attatataaa acgcgccaac aatgaagaag 1556401 gagcgaaaca gccagagctg ccttatattg ttgtcattgt ggacgagcta gccgatctca 1556461 tgatggtcgc ttcatctgat gtggaagatt cgattacgag attgtcccaa atggcgcggg 1556521 ctgccggcat ccatcttatt attgcgacac agcggccatc ggtggatgtt atcacagggg 1556581 tgatcaaagc gaacattccg tcacgaatcg cgttcagcgt atcttcacag acggattcaa 1556641 ggaccattct tgacatgggt ggcgctgaga agcttcttgg ccgcggcgat atgctgtttt 1556701 tacctgtagg ggctaacaaa cctgtccgtg tgcagggagc atttttgtcg gatgacgaag 1556761 tggagaaggt cgtcgaccat gtgattactc agcagaaagc gcaatatcaa gaagaaatga 1556821 ttcctgagga gacgacggaa actcattccg aggttactga tgaactttat gatgaagctg 1556881 ttgaattaat cgtcggcatg cagacggcat ctgtttcaat gctgcaaaga agattcagaa 1556941 ttggctatac gagagcggcg cgcctgattg acgcaatgga ggaacgcggt gttgtcggac 1557001 cgtatgaagg cagcaaacct agggaagtat tattatcaaa agagaaatat gatgagctct 1557061 cttcttaatg aagggagttc cgctttctat agttgtcaat aatgatatta tgtaaactga 1557121 tcacctttct atttattttt tcgacaaaac atgatatagt tgtcccaatt gttcaataat 1557181 ttttatcgaa agtggtttac ggaggggaaa catgtctaca aaagctgata atcggcactt 1557241 gtatttgaaa gtaattgaac gaattaaaga ggatataaaa aatgggatct acactgagaa 1557301 ggaaaagctg ccttctgaat ttgagctttc caaaaagctt ggtgtcagca gagcgacgct 1557361 aagagaagcc ttgcggatac tggaagaaga gcatgtgatt atcagaaggc atggtgtagg 1557421 cacttttgtc cattctaagc cgttatttct ttcgggtatt gaacagctga acagtgtaac 1557481 caagatgata gaacaggcga atatgacccc tggcacgatt tttctatcat cacaagtgct 1557541 tatgccgtct gaagatgata cgaagagatt tcacttggca gaagggcaag aactttttta 1557601 ccttgaacga gtcaggacag ctgacggaca gccgattgtg tattgtatag acaaaattcc 1557661 gatgaatatt ttgccgaatt ctttttctca tcagcaagaa tctatgtttg acctgctaga 1557721 gaaaaattca ggctccgtaa tcagctatgc agtaactgat atagaaccga tcggctatca 1557781 cgataccatt tctccagtgc ttgaatgcga tccggaaaca gctcttttgc tgttaaaaca 1557841 aacccattac gatcagcacg ataaaccggt gctttattct ttaaattatt ttagagcgga 1557901 taaattcaga tttcatgttt tgcgtaaacg attctaaaaa cggacgcctg tatgtgtctg 1557961 tttttttatt tgcactgatt catgtttctt tgtacatact ttcattccgg ttaacgcaat 1558021 atataaggga tgacaagaaa gtgaatgggt gaaaatgttg agagagaaaa atggaatgaa 1558081 aaatattatt gcattgtctt ctgtcccgct tgtgatgaca ctcgggaact ccatgctgat 1558141 tcctgttctt ccgatgatgg agaaaaagct gtctgtgact tcatttcaag tatctttaat 1558201 cattactgta tattcagtag tagcaattat ttgcattccg attgccggat atttgtcgga 1558261 tcgtttcggg agaaaaaaaa tattgcttcc atgcctcctc attgcaggat tggggggagc 1558321 cgtagctgct tttgcctcga cctatatgaa aaatccttat gctatgatct tggcggggcg 1558381 ggttcttcaa ggcattggtt ctgcaggtgc cgctccgatt gtcatgccgt ttatcggcga 1558441 cctgtttaaa ggagacgatg aaaaggtcag cgcgggtctt ggcgatattg aaaccgccaa 1558501 cacgtcaggg aaggtactga gtcccatact tggagcctta ctggcttctt ggtattggtt 1558561 tgtaccgttt tggtttattc cgtttttctg tttgatcagc tttttgctcg tattgttttt 1558621 ggtggccaag cctgaagaag atgaagatgc gcctgctgtt tctgagttta ttaagagtgt 1558681 gaagaaaatt tttaaacagg atggtcgctg gctttatacg gtcttcatta tcgggtgtgt 1558741 cattatgttt ttgttatttg gcgtattatt ttatttatca gatacgctgg agaacaagta 1558801 tgctattgac ggagtagcta aaggcggatt actggcaatc ccacttttgt ttttgtcaac 1558861 cagttctttt atagctggca aaaagatcgg taaagataaa ggccgaatga aattttgcgt 1558921 tgttacagga atgattctgt taaccctttc gtttattgcc ttgtggtgga accacagttt 1558981 ttatttttta tttgtctttt taagctttgg cgggattggg attggaatgg ctcttcctgc 1559041 tttagatgca ttgataaccg aagggattga aagtgaacaa tgcggaacca tttcctcctt 1559101 ttacaatagc atgcgcttta taggagtagc tctcggtcca cctgtttttg ctgcattaat 1559161 gtctaatgca aactggatta ttttcatact ctcggcgttt tgcagcatcg tttctttatt 1559221 tttagtgctc tttactgtag atgctaaaaa aagtgaagaa gaaaaaaact tagggacggt 1559281 ctagccagcc gtcttttttt gcgctttctt gcacagttta caactgtacc tatacagcat 1559341 gcggaggtta ttgtttcctt ataaatccta cagttgctat aattacatga aagagtgttt 1559401 ctgcggatgc tgaaaattgg tcataataca tactaattaa gaaatgaacg aaggaggttc 1559461 catatgtcat atgttaatga actcaaatca aagcacggcg gtttaaccgc acacattgta 1559521 aaaacagaaa aattcaaaac cgtctcgctt atttttaaga tgcttgcgcc gctgacaaag 1559581 gatcaagtca ccaaaagagc gcttctcccg catgtgcttc ttcgcggaac gaaaagccat 1559641 ccgaaaaccg caggattgcg ttcatacttg gatgagctgt acggcacgtc agtatcggct 1559701 gatcttacga aaaaaggaga gcggcatgtc attacgttca ggcttgaaat cccgaatgaa 1559761 aaatatttaa aagaccaaac gccgcttctc gagaaagggc tccagcttct cgcagaactc 1559821 gtcttttcac ctgctttgga gggagacgct tttcagtcac aatatgtggc tcaagaaaaa 1559881 cggacgctta agcaaagaat ccaagccgtc tatgatgata aaatgcgtta ttcgaattta 1559941 aggctgatac aggaaatgtg caaaaatgat ccttacgcgc ttcatgtcaa tggtgaaatc 1560001 gacgatgtcg atgacattac ggcagagcaa ttatacgaaa cataccaaag cgctatccaa 1560061 aaagaccagc ttgatctata tgttgttggc gacgtggaca gtaaccaggt acaatcggca 1560121 attgataagt atttcaaaac agaagagcgc actcttggca tgattgaaaa caatcacgct 1560181 gatgaaaaag ttcagccaaa agaagtaatt gatgaagagg atgtcaagca aggaaaactg 1560241 aatatcggct accgcaccag catcacttat acagatcagg attatcctgc tttacaagtg 1560301 tttaacggat tgttcggcgg attctctcat tctaaacttt tcattaatgt tcgggaaaaa 1560361 gccagtcttg cttactacgc ggcttcgcgt atagaaagtt ttaaaggctt gttaatggtg 1560421 atgtcaggca ttgaagtgaa aaattttgaa caggcggttt cgattattgc tgagcaattc 1560481 caggcaatga aaaatggcga tttcagtgag caggatatag cacagacaaa ggccgttatt 1560541 cgaaatcaag tgctggaaac gattgataca gcatacggtt tatctgagtt tttatatcag 1560601 caggccgctg ctcaagtcga gattcctatc gaagactttc ttgccaatat tgagaatgtc 1560661 acaaaagagg atatcattaa agccggcgaa aagattcagc ttgatacgac ttatttctta 1560721 aaagggacgg agggtgcatc ttgatcaaac caatcgaata tgaacagctt caggagacgc 1560781 tgtatcatga aaaaatgtcc aacggccttg atgtttacgt tttgccgaaa aaaggcttca 1560841 acaagacata tgcggtcttt acaacaaagt acggctcgat agataaccgg tttgtccctt 1560901 taggtaaaaa cgagatggtt cacgtgccgg acgggattgc tcactttctt gagcacaagc 1560961 tgtttgagaa agcggacgga gacgtttttc aagatttcag caaacagggg gcttctgcca 1561021 atgcgtttac gtcatttaca agaacggctt accttttctc aagcacatca aatgttgaac 1561081 gcaatttaga gacgcttatc gatttcgtac aggacccata ttttactgaa aaaacggttg 1561141 aaaaggaaaa agggattatc gggcaggaga ttaatatgta cgacgataac cctgattgga 1561201 ggctttactt cggggtcatt gaaaacatgt acaaagagca tcctgtcaga attgacatag 1561261 cgggaacagt ggaaagcatt tcacatatta caaaagacct tctttatgaa tgctatgaaa 1561321 cgttttatca cccgagtaac atgctccttt tcattgtcgg ccctgtagat cctgaagcga 1561381 ttatttctca ggtaagagaa aaccagggga aaaagccgta tactgatcag ccggagatca 1561441 aacgagaaga agtgaaagag caagaagcgg ttttccgaaa agaaaaagag atcaaaatga 1561501 acgtgcaggg accgaaatgc cttgttgggc tgaaatccaa aaatccgttt aaattaggca 1561561 aagagctctt aaagcatgaa ctttcaatga acttattgct tgaagctctt tttggcaaaa 1561621 gctctgccca gtatgaatca ctttatgaaa aaggatatat tgacgaaacg ttcagctttg 1561681 attttactgc tgaatatggg ttcggttttg cggcgatcgg cggagatacg cctgagcctg 1561741 atcaattggc tgaagacatt tcaagcatgc ttttgcgcgc cggtgaactg attactgctg 1561801 aaaagattga acttgccaga aagaaaaaga tcggcacatt cttaaaagcg ctgaattccc 1561861 ctgaatacat cgccaatcaa tttacccgtt atgcgttctt ggatatgagc ctgtttgatg 1561921 ttgtaacggt actcgagcag attaccctcg aggatgtcca gaacgtaata caagaggaaa 1561981 tcgctgcaga cagactgact gtctgcaagg ttgttcctaa atcataaaca aaacatccct 1562041 ccagtgtgag gggtgttttt ctgcggaaag aaggaaagag gatgaacaaa acagcactaa 1562101 tcaccggagc aagcggcggc attggcaaaa gcatcagcga aacccttgca gctagaggat 1562161 acaatctgct gctgcattac aatacaaatc aaaacgcggc agcggagctt gctgaaaaac 1562221 taagtcagat gtttggcgta aatgcggaga tattacaagc tgacctgtcc gcgcaagatg 1562281 gagcagataa gctgacaagt tcaattgttc agccgattga tgcgattgtt ttaaacagcg 1562341 gacgaagcca ttttgggctg attacggatg tagataacgc aacggtccag gaaatggttc 1562401 agcttcatgt ggcgagtccg tatatgctga cgagaaacct tctgccaggc atgattcgga 1562461 ataaatcggg agcgattgtg gctgtcagct cgatttgggg agagactgga gcatcctgtg 1562521 aagtgttgta cagcatggca aaaggagctc agcattcatt tgtaaaagga ttggctaagg 1562581 agctggcgcc aagcggaatc agagtaaacg ccgtagcgcc gggtgcagtt gatacaaata 1562641 tgatgaatca atttaccccg gctgaaaaag aagagatcgc tgatgagatt ccgatcggcc 1562701 ggctggcccg gccgcaagaa attgcggatg caacagcttt tctcctgtct gaaaaagcgt 1562761 catatatcac cggccaaatt ctgtcggtga atggcggctg gcactgctga tccgaaaata 1562821 ttcggtgtat agtttctttt gcgaaggaca caataatctt gtaacttcac atgaaatgga 1562881 ggaaacaagc atgtcagtat tagaaaactg ggatagctgg aaaaacttcc ttggcgaccg 1562941 tctgaactat gcgcaagata aaggtatgag ccaggatacg attacagatc ttgcgacaga 1563001 aatcggcagc tacttggcta atgaagtgga atctaagaac gagcaggaaa aagtgctggc 1563061 agatctttgg agtgtagcat caaaagatga acagcacgcc attgccaata tgatggttaa 1563121 gcttgttgaa aataacagca ctcactagga agagagggga tttttcctct cttttttatg 1563181 ttttcctcat cacagcaaca ttcttctttc taattagaga aaaatgcttt atgataaagg 1563241 aaggtaaaat tttgccacaa tgaagggggt atatcatttg gcaaagctcg aatggtattt 1563301 tgaatatgaa attcaagtga accgccccgg actgctcggg gatatttcat ctcttcttgg 1563361 gatgctttct atcaacatcg taacgataaa cggcgtcgat ctttccagaa ggggaatgct 1563421 cctcaggtgc cgccatatag atcaaattaa acgattagaa tcaatcttaa aaacgatgga 1563481 aacaattaaa gtaacgaagc ttagagaacc gaggcttcgc gaccgtcttg ccgtacgcca 1563541 cggccgttat attcaacggg atgccgatga caagaaaacg ttccgctttg aacgggacga 1563601 gcttggctta ttagtcgatt ttatggccga attgttcaaa aaagaaggcc ataaattaat 1563661 cggaatcaga ggtatgccgc gtgtcgggaa aacggaatcg attgtagcct ctagtgtgtg 1563721 cgagcaaaag gtggctgttt gtgtcatcaa ccttgctgaa gcagacgata agaagccagc 1563781 tgattgccga tgaatacagc actgaaaatg tctttatcgt tgacggaatt gtgtcaacac 1563841 gaagagggtc agaacgccat ctccagctgg tccgagaaat catgcggctg cctgcaacaa 1563901 aagtggtgga gcatccggac atattcgttc aaaatacaga gtatacacta gatgactttg 1563961 attatattat tgaactgaga aatgaccctg atgaggttat tacatatgaa catgccgagg 1564021 aaccccaaat gtttgatcaa tccgggtttt caagctttga tttttaaaat tggaaggtgt 1564081 ttgttgtgac tgaactagga atccggctca aagaagccag agaggaaaaa gcaatgtcat 1564141 tggatgatct ccaagcggca acaaagattc aaaaaaggta tttaaccgcc ttggaggaag 1564201 gaaactatga cattattccg gggaagtttt atgttcgggc attcatcaag caatatgcag 1564261 aagccgttgg gcttgatgcg gatcagctgt ttgaggagca taaaaaagat atccctaata 1564321 cgtatcatga tgatgtgtct gaaaagatct ccggcatgaa tcttcaaaag gaaatgccaa 1564381 agccagcatc taaggcgctg gagctgctgc caacaatact tgttattctc ggcgtgattg 1564441 tcgtgattgc cattgtgtac gcgatcattc aatttgccaa tcacaaaaac agtgatgatc 1564501 acaatgcggc atcagaaaaa gcaattacgc aaagtgagag caagtacgaa atccctaaag 1564561 attcaacgct gaaagagaat caaaataaca gctctgaaaa agagacagac actaaaaaag 1564621 aaacgaaaga aaacgaagat aagaaaaaag aaaatgacag tgagaagctg gagattaaag 1564681 ctgctggcac tgaaggatcg ttaacgactt atgaagtgtc cggcgctgat aaaatcgagc 1564741 tggaactgaa ggcatcagac agctcctgga ttagagtgcg cgatgaaaac agcagctctt 1564801 taaaagaagg aacgctgaaa aaagacgaaa cctataaaaa agacataact gatcagaaac 1564861 aagttgatat ccgcaccgga tatgcaccta atctgaaaat aaaaatcaac ggtaaggttc 1564921 tttcatatga acttgatccg aaaaaagtga tggcacaaac cataaagatt gtaaataaaa 1564981 aggaagaaaa gtcatcttaa ttaccagatg acttttcttc acgtccgagt atgaaattgg 1565041 aggggcttta tgtttaactt accaaataaa atcacactag ctagaatcgc attaatccca 1565101 atcttcatga ttatcatgct ggcgccgttt gactggggca ggctcgaagt tggagacgaa 1565161 tccatcccgg tcgcacattt ggcgggggcc attctattta ttattgcatc tacaacagac 1565221 tgggtggacg ggtattatgc ccgaaaatta aatctcgtaa caaacttcgg gaaatttctt 1565281 gatccgcttg cggacaaact gctcgtatcc gcagcgttaa ttatccttgt tcaatttgat 1565341 ctcgctccag cttggatggt cattgtgatt atcagcaggg agtttgccgt gacaggttta 1565401 aggcttgtct tagccggaac aggagaagtc gtagctgcta acatgcttgg taaaatcaaa 1565461 acctgggcac agattattgc ggtatctgca ttgcttcttc ataatcttcc atttgaactt 1565521 gtgtcattcc cgtttgcaga cttggcgctg tgggtagccg tcttctttac tgtcgtctca 1565581 ggctgggaat atttctctaa aaattgggaa gcgttaaaaa catctaacta agaaagaagg 1565641 acttcgtcat ggaatttcca aaaaaagcag aaataattgc agtcggttca gagttgctgc 1565701 ttggtcaaat cgccaataca aatgctcaat ttatcagcaa acagctcgct gaaatcgggg 1565761 tcaacgtatt ttatcataca gcggtcggag ataacccgga gcggctgaag caggtcatcc 1565821 gcattgctga agaacgctct gacttcatta ttttttcagg agggcttgga cccacaaaag 1565881 atgatctgac gaaagaaacg attgcaaata cgctgggacg tccgcttgtg ttaaatgatg 1565941 aggcattcca atccattgag gactatttca aacgaacaaa acgcacgatg tcacctaata 1566001 accgaaaaca ggcgcttgtg atcgaaggct ctgacgtgct ggcgaatcac tttggaatgg 1566061 ccccgggaat gctcacagag catgaatcgc gctattatat gcttcttcct ggaccgccga 1566121 gcgaattgcg tccaatgttt gaaaacgagg caaagcctct tctgctgaaa aagatgggtt 1566181 caaatgaaaa aattgtgtca actgttcttc gctttttcgg tatcggtgaa tctcagcttg 1566241 aagccgattt ggaagatatt attgatgcac aaaccaatcc gacaattgcg cctttggcgg 1566301 ctgatggaga ggtgacgctg cgtctgacag ccaaacacgc cgatgaaaag gaaacagagc 1566361 gtctgttaaa agaaacagag gccgttatct tagagcgtgt cggtgaattt ttctatggtt 1566421 acgatgatac ttctcttgta aaagagctat ctatagcatg taaggaaaaa ggcataacaa 1566481 tttctgcggc agaaagcttt accggagggc tgttttctga atggctgacg gatcatagcg 1566541 gtgcctcaaa attatttgcc gggggcgttg tttgctatac aaacgacgtg aagcagaatg 1566601 tgcttggtgt caagaaggaa acattagatc gttttggggc ggtcagcaag gagtgcgcat 1566661 ccgaactggc taagggtgtt caaaaactca ctggcagcga tatcggcatt agctttactg 1566721 gtgtagcagg acctgatgct caagaagggc atgagcctgg gcatgtgttt atcggcattt 1566781 ccgcaaatgg taaagaagag gttcacgagt ttcactttgc gggctccaga acggggatca 1566841 gaaaacgcgg cgctaaatac ggctgccatt taatcttaaa gcttttagag caaaaataat 1566901 attttcagca cattatcctc ctaagaaaac atgatttctc tgatacatta tgatattttg 1566961 ataggaatca cgccaagaaa aaatccgaat atgcgttcgc ttttttcttg gcaaatccct 1567021 tcaaacaggg tatagtatat gtagtggtaa cataaaggag gaaaaaatag aatgagtgat 1567081 cgtcaggcag ccttagatat ggctcttaaa caaatagaaa aacagttcgg caaaggttcc 1567141 attatgaaac tgggagaaaa gacagataca agaatttcta ctgtaccaag cggctccctc 1567201 gctcttgata cagcactggg aattggcgga tatcctcgcg gacggattat tgaagtatac 1567261 ggtcctgaaa gctcaggtaa aacaactgtg gcgcttcatg cgattgctga agttcagcag 1567321 cagggcggac aagccgcgtt tatcgatgcg gagcatgcgt tagatccggt atacgcgcaa 1567381 aagctcggtg ttaacatcga agagctttta ctgtctcagc ctgacacagg cgagcaggcg 1567441 cttgaaattg cggaagcatt ggttcgaagc ggggcagttg acattgtcgt tgtcgactct 1567501 gtagccgctc tcgttccgaa agcggaaatt gaaggcgaca tgggagattc gcatgtcggt 1567561 ttacaagcac gcttaatgtc tcaagcgctt cgtaagcttt caggggccat taacaaatcg 1567621 aagacaatcg cgattttcat taaccaaatt cgtgaaaaag tcggtgttat gttcgggaac 1567681 ccggaaacaa cacctggcgg ccgtgcgttg aaattctatt cttccgtgcg tcttgaagtg 1567741 cgccgtgctg aacagctgaa acaaggcaac gacgtaatgg ggaacaaaac gaaaatcaaa 1567801 gtcgtgaaaa acaaggtggc tccgccgttc cgtacagccg aggttgacat tatgtacgga 1567861 gaaggcattt caaaagaagg cgaaatcatt gatctaggaa ctgaacttga tatcgtgcaa 1567921 aaaagcggtt catggtactc ttatgaagaa gagcgtcttg gccaaggccg tgaaaatgca 1567981 aaacaattcc tgaaagaaaa taaagatatc atgctgatga tccaggagca aattcgcgaa 1568041 cattacggct tggataataa cggagtagtg cagcagcaag ctgaagagac acaagaagaa 1568101 ctcgaatttg aagaataaaa ataaaataag tttcaaatga tacaaaaggc tgagtgaaaa 1568161 actcagcttt tttgtatttt gcaaaaaaat gataaaaata ttgctttttt tgacaacttt 1568221 tttagggctt tattcgtcta acaaaacgtg tgcaaaatgg aatttatttt gggaggaaaa 1568281 aatgaatgac aagcccaacc cgcagaagaa ctgcgaaacg cagacggaga aaactaaata 1568341 aaagaggaaa actgttgttt ggtcttttag cagtgatggt ttgcattacg atttggaatg 1568401 ctcttcatcg aaatagtgaa gaaaacgaac catctcaaga aactgcagcg gtttcaaata 1568461 ccgatcagaa aaaagaggtc aaaaagaaaa ctgccaaaaa atcagaggaa caaatcaaaa 1568521 cagtggatcg aaaccaaaaa atcagcaatt atttaaaaga gatcggtttc agcggaacag 1568581 ccatgattgt cagaaatgga gaaatcgtaa caaataaagg ttttggctat gctgaccgta 1568641 aacactacat tcaaaataat ccattgacat ctttttatgt cggttcatca caaaaagcgc 1568701 tgattgcaac tgctattttg cagcttgagg aaaaggggaa acttcagaca agtgatccgg 1568761 taagcacgta tttacctcat tttcccaacg gacaaacgat tactttgaag aatctgctta 1568821 cacatacatc ggggataaac ggacatattg aaggaaacgg cgccattact ccggacgatt 1568881 taataaaaga tatagaactt cagggaatca aacgtcagcc gggcgtatgg gactacaagg 1568941 attccaacta ttctgttctt gcttatatta ttgctgaagt aagcggtgag ccctatgaac 1569001 agtacataaa gaatcatatt tttaaacctg cgggaatgac gcatgcaggc ttttacaaaa 1569061 catatgaaaa agaaccttat cctgccgtcg ggtataagat ggagggcagc aaaacagtta 1569121 caccgtatat acctgattta tcccagctgt atggagcggg tgatatttat atgagcgcta 1569181 tagatatgta caaatttgac caagcgctga tagacggaaa actgtattcg caaaaaagct 1569241 atgaaaagat gtttacgcca gggagcagct ccacatacgg catgggattt tatgttgctc 1569301 ccggaagcta ttcaaaccat ggtgttatgc cgggcttcaa tatcttgaac agctttagca 1569361 aatctgggca aaccattgtt attttgttct caaacattca aaataatgct aaattgggcc 1569421 aagtgaacaa taaaatatac cagcttctaa atcaagaatg attggcgatc ttcttttgga 1569481 tgaattgcat tcggcacgtg aaaagaagac tggcctgcaa acgttaagat ggcaagcttg 1569541 acaagtattt ccgacacatt tacaatgaag ttgtaacatt tgttttttta acatgattgt 1569601 taaaccattt aaacttgaca agggcgatga acacactcat tccctgtgaa ggttctgtat 1569661 gttgagaaaa ctagacaatg tacatgccga cactttttaa gcaacaacca agttcatagc 1569721 aagaggaggt gaaagtatga ccccaattat gatggttctc atctccattt tgctgattct 1569781 actcggttta gttgttggct actttgttcg taaaaccatt gccgaagcga aaattgcggg 1569841 cgcacgcggt gcagccgagc aaattcttga agatgcgaag cgtgatgctg aagcactgaa 1569901 aaaagaagct ctgcttgaag caaaggatga aatccacaaa cttcgaatag atgctgaaca 1569961 ggaagttcgt gaaagacgaa atgagcttca aaaacaagaa aaccgtttac tccaaaagga 1570021 ggaaaacctt gatcgcaaac atgagggaat tgataaacgg gaagcgatgt tggagaagaa 1570081 agatcattct ctgaatgaac gacaacaaca tattgaagag atggaaagca aagtggatga 1570141 gatgattcgt atgcagcagt ctgagttgga acgaatttcg agtctgactc gtgacgaagc 1570201 gaaacaaatc attcttgagc gggttgaaaa cgagctttca catgacatcg ccatcatgac 1570261 aaaagaaact gaaaaccgtg cgaaagaaga ggcggataag aaagcgaaaa acattctttc 1570321 actcgcctta cagcgctgcg cagcggacca cgttgccgaa acaacggtat cagttgtcaa 1570381 tcttccaaat gatgagatga aaggacgtat catcggacgg gaagggcgta acattcgtac 1570441 gcttgaaacg ctgacaggaa ttgacctgat tattgatgat acgcctgaag ctgtcattct 1570501 ttccggattt gatccgatca gacgtgagac agccagaatt gctcttgata aactcgttca 1570561 ggatggccgt attcatccgg cacggattga agaaatggtt gaaaaatctc gccgcgaggt 1570621 cgatgactat attcgtgaga tgggtgagca aacgacattt gaggttggcg ttcatggcct 1570681 ccacccagat ctcatcaaga tcctcggccg cttaaagttc cgtacaagct acggtcaaaa 1570741 tgtgcttaag cattccatgg aagtcgcatt cttggccggt ctaatggcat cggagcttgg 1570801 tgaagacgca aagcttgcta aacgtgcggg tcttcttcac gacatcggga aagcaattga 1570861 ccatgaagta gaaggaagcc acgttgagat cggggtagag cttgcgacca aatataaaga 1570921 gcacccagtc gtgattaaca gtattgcatc acaccacggg gacgaggagc cgacttccat 1570981 tattgctgta ctggtagctg cagcagatgc gctttccgct gcaagacctg gcgcaagaag 1571041 tgagacgctc gagaattata ttcgaagact tgaaaaactt gaagaaattt ctgagtccta 1571101 cgaaggtgtt gaaaaatcat ttgccattca ggctggacgc gaagtgcgaa ttatggtgaa 1571161 gccggattca attaatgatc ttgaggctca tcgactggcg cgagatatcc gcaagcgaat 1571221 tgaggacgag ctcgattatc caggtcatat taaggtgaca gtaatcagag agactcgagc 1571281 cgtagagtat gcaaaataaa gtgatgcgct aagcatcact ttattttttt gacggcaagg 1571341 aattttcaag aagaaaggat ttacaaaatg agaattttat ttatcggaga tgttgtcggt 1571401 tcaccgggcc gtgacatggt caaagaatat gtaccaaagc taaaaacaaa atataagcct 1571461 cactttacca ttattaatgg tgaaaacgcc gcacatggaa aaggcctgac ggaaaaaatt 1571521 tatcacagct taatccagtc cggcgcagat gcaatcacaa tggggaacca cacatgggac 1571581 aaaaaagaaa tatttgattt tatagatgac gttccgaact tggttcgccc ggcaaacttt 1571641 cctgaaggaa caccggggaa agggatcaca tatgtgaaag caaacggcaa agaactagca 1571701 gtcattaatt tgcagggacg tacgtttttg ccgccgcttg atgacccgtt tttaaaagcg 1571761 gatgaattga tcgcagaagc tgcgaaaaga acaccgtaca tttttattga ctttcatgcc 1571821 gaagcgacaa gtgaaaagct cgcacttggc tggtacacgg atggacgggc atcggctgta 1571881 gtaggaactc atacacacgt gcaaacagcg gataaccgca ttttgccgaa gggaacggca 1571941 tatattactg atgtgggaat gactggcccg tatgacggta tactggggat ggacagagag 1572001 acgattatta agcgattcaa aacgaacctt ccagtccggt ttactgtcgc tgaaggaaaa 1572061 acaacgctca gcggagttgt cattgacatt gacgatcaaa cgaaaaaagc cgtgaaaatt 1572121 gagcgtattt taatcaacga tgatcacatg ttctttgaat agttgaacat atggttattt 1572181 tataaaaata ttaaaaagaa aagcaggaat atagcaactc cttagtgaat atagtaaaaa 1572241 tggaaggtag cccgctattt ttgaaaagca ttgtggggat ggctttttgg atagcaacat 1572301 ctaataatga ttgttctaat gaacactcac ttatccattg taaaactaag ggggagcaga 1572361 aatggaaatc ttaaaagttt cagcaaaatc gagtccaaat tcagtggcag gtgcgcttgc 1572421 aggcgtgttg agagagcgag gagccgccga gattcaagcg atcggagcgg gtgcattaaa 1572481 ccaggctgta aaagctgtgg cgattgccag gggatttgtg gcgccaagcg gcgttgattt 1572541 gatttgtatt ccggctttta cagatattca aatcgatggg gaagaaagaa cagcgattaa 1572601 attaatcgtg gagcctcgct aaaaacaaat aaagcattct caacctgttt gcgtaatgca 1572661 aacaggttgt ttttcattta ttgtgatatt ttctcccgat agtattttta gcacataaat 1572721 gagcgaatat acaaaatcag aaatgagcta aaacgtttca aaaaaaattt ccgcccattt 1572781 ttcaagacag atacttttgt ccttctggaa aagacagttc tgtttacgct tattccatat 1572841 catggtacaa tccgaatata acaagaattt ttcaaggagg attgtacatg cagagtggaa 1572901 agatgaaagc tctaatgaaa aaggacgggg cgttcggtgc tgtgctgact gaagttccca 1572961 ttcctgagat tgataaacat gaagtcctca taaaagtgaa agccgcttcc atatgcggca 1573021 cggatgtcca catttataat tgggatcaat gggcacgtca gagaatcaaa acaccctatg 1573081 ttttcggcca tgagttcagc ggcatcgtag agggcgtggg agagaatgtc agcagtgtaa 1573141 aagtgggaga gtatgtgtct gcggaaacac acattgtctg tggtgaatgt gtcccttgcc 1573201 taacaggaaa atctcatgtg tgtaccaata ctgctataat cggagtggac acggcaggct 1573261 gttttgcgga gtatgtaaaa gttccagctg ataacatttg gagaaatccc gctgatatgg 1573321 acccgtcgat tgcttccatt caagagcctt taggaaatgc agttcatacc gtactcgaga 1573381 gccagcctgc aggaggaacg actgcagtca ttggatgcgg accgattggt cttatggctg 1573441 ttgcggttgc aaaagcagca ggagcttctc aggtgatagc gattgataag aatgaataca 1573501 ggctgaggct tgcaaaacaa atgggagcga cttgtactgt ttctattgaa aaagaagacc 1573561 cgctcaaaat tgtaagcgct ttaacgagtg gagaaggagc agatcttgtt tgtgagatgt 1573621 cgggccatcc ctcagcgatt gcccaaggtc ttgcgatggc tgcgaatggc ggaagatttc 1573681 atattctcag cttgccggaa catccggtga caattgattt gacgaataaa gtggtattta 1573741 aagggcttac catccaagga atcacaggaa gaaaaatgtt ttcaacatgg cgccaggtgt 1573801 ctcagttgat cagttcaaac atgatcgatc ttgcacctgt tattacccat cagtttccat 1573861 tagaggagtt tgaaaaaggt ttcgaactga tgagaagcgg gcagtgcgga aaagtaattt 1573921 taattccata aagggggata aacatgacga aggaatttga gtttttaaaa gcagagctta 1573981 atagtatgaa agaaaaccat acatggcaag acataaaaca gcttgaatct atgcagggcc 1574041 catctgtcac agtgaatcac caaaaagtca ttcagctatc ttctaataat tacctcggat 1574101 tcacttcaca tcctagactc atcaacgccg cacaggaggc cgttcagcag tatggagccg 1574161 gcaccggatc agtgagaacg attgcgggta catttacaat gcatcaagag cttgagaaaa 1574221 agctggcagc ctttaaaaaa acggaggcgg cacttgtatt ccaatcaggc ttcacaacaa 1574281 accaaggcgt actttcaagt attctatcaa aagaggacat tgtcatctca gatgaattga 1574341 accatgcctc tattattgac ggaattcgac tgacaaaggc ggataaaaag gtgtatcagc 1574401 acgtcaatat gagtgattta gagcgggtgc tgagaaagtc aatgaattat cggatgcgtc 1574461 tgattgtgac agacggcgta ttttccatgg atggcaacat agctcctctg cctgatattg 1574521 tagagctcgc tgagaaatat gacgcatttg tgatggtgga tgacgcccat gcatccggag 1574581 tacttggcga aaacggcagg ggaacggtga atcacttcgg tcttgacggc agagtgcata 1574641 ttcaggtcgg aacattaagc aaggcaatcg gagtgctcgg cggctacgct gcaggttcaa 1574701 aggtgctgat cgattatttg cgccataaag gccgtccatt tttattcagc acatctcatc 1574761 cgccggcagt cactgcagct tgtatggaag cgattgatgt cttgcttgaa gagccggagc 1574821 atatggagcg cttgtgggag aatactgcct attttaaagc aatgcttgtg aaaatgggtc 1574881 tgactctcac gaagagtgaa acgccgattc ttcctatttt aataggtgat gaaggtgtgg 1574941 caaagcaatt ttcagatcag ctcctttctc gcggtgtttt tgcccaaagt atcgttttcc 1575001 cgactgtagc aaagggaaaa gccagaattc gcacgattat aacagcagag cacaccaaag 1575061 atgaactgga tcaggcgctt gatgtcatcg aaaagacggc aaaggagctc cagctattgt 1575121 aacaagagga agagtttact cttcctcttt tgattcctta ttgattatta ttctcaatga 1575181 gtgtacaatg ataggttgcc agttgtgcag agcttcaata acctttatac tgaagggtgg 1575241 aagtttggtt tgaaaggaga aaatatgaca tgaatgaaaa acaaaaatta gagagcggac 1575301 aagttcatcc atcggacaaa aaatccgaga aggattacag caagtacttt gaagctgttt 1575361 acattccgcc ttctttaaaa gacgcgaaaa aacgaggcaa ggaagccgtt acttatcata 1575421 atgactttaa aatttctgaa caatttaaag gattgggaga cggaagaaag ttctatatcc 1575481 gtacgtacgg ctgccaaatg aatgaacacg atacagaggt tatggcaggg atctttatgg 1575541 cgctcggtta cgaagcgaca aactctgttg acgatgccaa tgtcattttg ttaaatacat 1575601 gtgcaatccg tgaaaatgct gaaaacaagg tgtttggtga gctcgggcac ttaaaagcac 1575661 tgaaaaaaaa caatcccgat ctgattttag gcgtgtgcgg ctgtatgtcc caagaggaat 1575721 cagtcgtgaa ccgtattttg aaaaaacatc cgtttgtcga tatgattttc ggaacgcata 1575781 acattcatcg cctgccggag cttttgtcag aagcatacct ttcaaaagaa atggttgtag 1575841 aagtttggtc taaggaaggg gacgttattg aaaaccttcc aaaagtccga aatggaaaaa 1575901 ttaagggctg ggtcaatatc atgtacggct gtgacaaatt ctgtacgtat tgcattgtgc 1575961 cttacacacg cggaaaagaa agaagccgcc gccctgagga tatcattcag gaagtgagaa 1576021 ggctcgcaag tgaaggctat aaggaaatta ctctgttagg ccaaaacgta aacgcgtatg 1576081 gaaaagactt tgaagatatg acgtacggac ttggtgattt gatggatgaa ctgagaaaaa 1576141 tcgatatccc gagaatccgt tttacaacga gtcatccgcg cgactttgac gaccgcctca 1576201 ttgaagtgct ggcaaaaggc ggaaatctgc ttgatcacat tcatcttccg gttcaatcag 1576261 gaagctcaga agttctcaag ctgatggccc gcaaatatga cagagagcgt tacatggagc 1576321 tggtgcgaaa aattaaagaa gcaatgccaa acgcttcttt gacaacggac attatcgtcg 1576381 gatttccaaa tgaaacggac gaacagtttg aagaaacgct ttctctatac cgtgaagtgg 1576441 agtttgacag cgcctatacg ttcatttact ctccgcgtga aggcactccg gctgctaaga 1576501 tgaaagataa tgtaccgatg cgtgtgaaaa aagaacgcct gcagcgtcta aacgcactgg 1576561 tgaatgaaat ttctgctaaa aaaatgaagg aatacgaagg caaggttgtc gaagtattag 1576621 ttgagggtga aagcaaaaat aaccctgata ttcttgctgg ctatactgaa aaaagcaagc 1576681 ttgtcaattt caaagggccg aaggaagcca tcggcaaaat cgtccgcgtg aaaatccagc 1576741 aagcgaaaac atggtcgctt gacggagaaa tggtaggaga agcaatcgag gtgaaatgag 1576801 atgacgctct actcaaaaaa agacattgtg cagcaggctc gaaaccttgc aaaaatgatt 1576861 tctgaaacag aagaggttga ttttttcaaa cgggctgaag cgcaaatcaa tgagaatgac 1576921 aaagtgtcca caatcgttaa tcagattaaa gccctgcaaa agcaggctgt caatctgaag 1576981 cattatgaaa agcatgaagc gctcaaacaa gtagaagcaa aaattgacgc gctgcaagaa 1577041 gagcttgaag agattcctgt tatccaggaa ttcagagact cgcaaatgga agtaaatgac 1577101 ctactgcagc tcgttgcaca caccatttcc aaccaagtca caaatgaaat catcacatca 1577161 accggaggcg acctgctgaa aggggaaacc ggttcaaagg tgaagcattc aaataacagc 1577221 tgttctctct aaacacggtg cctttacagg cccgtgtttt tttatcattt gtgcggttaa 1577281 aaatgaacta aataatctat gtaccaaatg ttcaattggt ttttctgtgc tcagccgcgt 1577341 ataaacttta tcgcacttat aagtaaagtt tctaggcacc cctgcataca atggaacaga 1577401 aactttgtat ttttatattt tatttataaa aatgcacact agacaaatgc ccagcataag 1577461 ataacacgaa gaagaacaag gaggcatgcc ggaatgtctg aatacaggga aattattacg 1577521 aaggcagtag tagcgaaagg ccgaaaattc acccaatgca ccaacaccat ctcgcctgag 1577581 aaaaaaccga gcagcatttt gggtggttgg attattaacc acaagtatga cgctgaaaaa 1577641 attggaaaaa cggtagaaat tgaagggtat tatgatataa acgtatggta ctcttacgcg 1577701 gacaacacaa agacagaggt tgtcacagaa cgggtaaaat atgtagatgt cattaaactc 1577761 agatacagag acaataatta cttagatgat gagcatgaag tgattgccaa agtgcttcag 1577821 cagccaaact gccttgaagt gaccatttcg ccgaatggaa ataaaatcgt tgtgcaggca 1577881 gaaagagaat ttttggcgga agtggtaggg gaaacaaagg tagttgttga ggtcaatcct 1577941 gactgggaag aggatgacga ggaagattgg gaagatgagc ttgatgaaga gcttgaagac 1578001 atcaacccgg agtttttagt gggagatcct gaagaataaa aaagggacta ggggagacag 1578061 tacccccaag tctctttttt atattgatat atcattcttt tatcactttt tgtttatgtt 1578121 ataatgaagg ttggaaaata gaaacgttga tacatagtga gggattaaac aatggccggt 1578181 tatacgccta tgatacagca atatttaaaa ataaaggcag agcaccagga tgccttttta 1578241 ttttttcgcc tgggtgattt ttatgaaatg ttttttgagg acgccaaaaa agcgtcacaa 1578301 gagctggaaa ttacgttaac gagcagagac ggcggtgcgg ctgaaaaaat accgatgtgc 1578361 ggtgtgccgt atcattctgc ttccgcgtat atcgaacagc ttattaaaaa aggatacaaa 1578421 gtggcgatct gtgaacagac ggaagatccg aaagccgcaa agggcgttgt gaaaagagaa 1578481 gtagttcagc tgattacgcc cggaactgta atggacggca aaggcatcca tgagtcggaa 1578541 aataatttta tcgcatctgt ttcagcctgc tcgaacggat acggacttgc tctgtctgat 1578601 ttaacaacgg gagaaaattt ggctgttttg attgaacggc ttgaagacgt catatcagaa 1578661 atttattcag tcggcgcacg ggaaatcgtg gtttcaggaa gcttggatgc cgatacagtg 1578721 gcacagctga gagagcggtg cggtgcaacg atttcaattg aagacggaga aacagacgaa 1578781 cacgtaacga tcattgagca cttaaataat gaagatataa caaaaacatt tctgcgctta 1578841 tatacgtatt tgaaaagaac ccaaaagcgc agccttgatc atcttcagcc cgtgcaggtg 1578901 tatgagcttg aggaagcgat gaaaattgac ttgtactcaa agcgtaatct ggagctgacc 1578961 gaaacgattc gttcgaaaaa taaaaaaggc tcccttttgt ggctgctgga tgaaacaaaa 1579021 acggcaatgg gaggccggct acttaaacag tggattgacc ggccgcttat cagagtcaat 1579081 caaatcgaag agcgccaaga aatggtggaa acattaatgt cccatttctt tgaacgggaa 1579141 gatctgcgtg aacgtttaaa agaagtatat gacttagaac gccttgccgg ccgcgttgca 1579201 ttcggaaatg tcaatgcccg ggatttgatt cagctgaagg aatcgttaaa gcaagtgcct 1579261 ggcatcaaac agctggttgc ttcactggct catgacaagg ccaaggaacg tgcaaagcgc 1579321 attgaccctt gcggggatgt acttgaactg ctggaagaag cgctgtacga aaaccctcct 1579381 ttatcggtaa aagaagggaa cctgattaaa gatggttata atcaaaagct tgatgaatat 1579441 cgtgatgcaa gcagaaacgg aaaagactgg attgcccgcc tggaacagca ggagcgggaa 1579501 tacacaggca ttcgctcttt aaaggtcggc tttaataaag ttttcggtta ttacattgaa 1579561 gtgacaaaag caaacttgca tttgcttgag gaagggcgtt atgagcggaa gcagacgtta 1579621 accaatgcag agcgctacat tacacctgaa ttaaaagaaa aagaagcgct cattttagag 1579681 gcggaaaata acatctgtga gctggagtac gagctgttta ccgagctgcg cgagaaagtg 1579741 aagcagtata ttccgcggct gcagcagctt gcaaaacaga tgagcgagct ggacgcactg 1579801 caatgctttg cgacaatcag tgaaaatcgc cactacacga aaccagagtt ctctaaagat 1579861 gaagtcgaag tgattgaagg cagacacccg gttgttgaaa aagtcatgga cagccaggaa 1579921 tatgtcccga acaactgtat gatgggcgat aacagacaaa tgcttctcat tacaggtcca 1579981 aacatgtcag ggaaaagcac gtatatgaga caaatcgcgc tcatttccat tatggcgcaa 1580041 atcggctgct ttgtacccgc gaaaaaagcg gtgctcccga ttttcgatca aatttttacg 1580101 cgaatcggcg ctgcagatga tttgatttcc ggacaaagta catttatggt agaaatgctt 1580161 gaagcgaaaa atgcgattgt caatgcgacg aaaaacagcc tcattctgtt tgatgaaatc 1580221 gggcggggaa cgtccactta tgacggcatg gcgctggcac aggcgattat tgaatatgtt 1580281 cacgatcata tcggcgccaa gacgctgttc agcacacact atcacgagct gaccgttctt 1580341 gaggacaagc tgccccagct gaaaaacgtt catgttcgcg ctgaagaata taacggaacg 1580401 gttgtctttc ttcatcaaat taaagaaggt gcggctgata aaagctatgg tatccatgta 1580461 gctcagcttg ccgaactgcc gggagatctg attgcgcgcg ctcaagatat tttaaaagag 1580521 cttgagcatt caggaaacaa accggaagtg ccggtgcaga aacctcaggt gaaagaagag 1580581 ccggcacagc tgtccttttt tgacgaagcg gaaaagccgg ctgaaacacc aaagctttca 1580641 aaaaaagaaa agcaagtgat cgatgctttc aaatcactta atatactgga tatgacaccg 1580701 cttgaagcga tgaatgaaat gtacaagctg caaaagaaat tacattaaaa cggggtgatg 1580761 aatgtggcaa aagtcatcca actgtcagat gagctttcaa ataaaatagc ggcgggcgag 1580821 gttgtggaac ggcccgcctc agtcgtcaaa gaattggtgg aaaatgcgat cgacgctgac 1580881 agcacagtca ttgaaatcga tattgaggaa gcaggccttg catccattcg ggtcttggat 1580941 aacggcgaag gaatggagaa tgaagattgc aagcgagctt tccggcgcca cgcaacgagt 1581001 aaaataaaag atgaaaatga tttattcagg gtgagaacgc tcggtttcag gggagaagcc 1581061 ctgccgagta tcgcgtcagt ctctcatctg gagattacaa caagcactgg tgaaggagct 1581121 gggacgaagc tcgtcctcca aggaggaaac atcatttccg aatcgcgttc ctcaagcagg 1581181 aagggaactg aaattgtcgt ttccaacctg ttttttaaca caccggcccg tttgaaatat 1581241 atgaaaaccg ttcatacaga gcttggaaac attacagatg tggttaaccg tattgctctg 1581301 gcgcatccag aggtatcgat ccgcctgcgc catcatggga aaaacctgct tcaaacgaac 1581361 ggaaacggag atgtgcgcca tgtactggca gcgatttacg gcacggctgt cgccaaaaaa 1581421 atgcttccgc tgcatgtgag ctccttggat tttgaagtaa agggatatat cgccctccca 1581481 gagattacac gggcgtcgag aaactatatg tcgtctgtgg tcaatggccg ttacattaaa 1581541 aatttcccgc tcgtcaaagc ggttcatgaa ggctatcata cgcttctgcc gatcggacgc 1581601 catccgatta cttttataga aattacgatg gacccgattt tagtcgatgt caacgtgcat 1581661 ccatcgaagc ttgaggtccg gctcagcaag gaaacagagc ttcatgactt aatacgtgac 1581721 ggaattaaag atgtgtttaa acagcagcag ctgattccta gtgcccaggt cccgaaaaaa 1581781 tcagcacctg ccatcaaaaa tgagcagcag tttataacct ttgatgaaaa gcctccggaa 1581841 aaaaaagttc cggaaaaatc gactgcgcca tcttattcac cgatgaagct cagctcagtc 1581901 gtaaaagagc cggttgatgc ggaggaaaaa ttgccccctc tccaatttga tgctcctcct 1581961 atcgttgatc aggaacaaac ccttgaggtg tccgatgttt cagcagaaca gcctgaaaca 1582021 tttgagcagg aatgccatga ggaacagccg cagccagcgt ctgatcgggt tccaattatg 1582081 tacccgattg gccagatgca cgggacttat atattggcac aaaacgaaaa cggcctatat 1582141 attatcgacc agcacgccgc ccaagaacgt attaaatatg agtacttccg tgaaaaggtg 1582201 ggggaggttg agcctgaggt gcaggagatg attgtaccgc tgacgttcca ctactccaca 1582261 aatgaggctt tgattattga acagcacaaa caagagctcg aaagcgtcgg tgtcttttta 1582321 gagtcattcg gctctaacag ttacatcgtc cgctgccacc cagcctggtt tccaaaggga 1582381 gaagaagcag agcttataga agaaatcatt cagcaggtgc tcgactccaa aaatatagat 1582441 attaaaaaac ttcgcgagga agcggcgatt atgatgagct gcaaaggctc catcaaagca 1582501 aatcgccacc tcagaaacga cgaaatcaaa gcgcttctgg acgacctccg aagcacatca 1582561 gacccattta catgcccgca cggccgcccg atcatcattc accactcgac atatgagatg 1582621 gaaaagatgt tcaaacgcgt gatgtagcgg gggtggtagg cattgatcca ttctctgaat 1582681 ggatcaatgc tttttttgta ctccttcgag tgtcagatta taagaaacgg ttgtaaacgt 1582741 gtgagcagtg ttaacgcatt atacttcatg gttcctccgt ataacaaaat ttccatttac 1582801 aggcaattgg gattaatgta tattttgggt gagggggtgg aaacatatgg catgtggtcc 1582861 gaagatcatt atctttttgg atgaacttga tgatccaaat gtgagaatca ttttagaatg 1582921 cagaatttaa attacaacat tgtgttttgc tccctgttcg tgtgaacagg gagatttttt 1582981 cgtttatata actggtgatg tccaaatata gggtgttatg aattttccat atctgccatc 1583041 ggctttaagc tgcttctcta ttaggctggt tatcaaaagc aagttcaatg atagccatga 1583101 aagctgatat cacaacaagc aagacatctg gaatataaat agactgcata aagtaatctg 1583161 caaaacagat cgttataaga ttgctgataa aatacagtat aaaagcaaaa agtgcagtct 1583221 ttttcaatga aagtgatttt gccaaaatga tagagataat ctttgtgagt gggtctatga 1583281 ttaaacctac agcaaagcag gctaaaataa ataaagctaa tgtttgattg gaagcgtatg 1583341 tgatgccaag tatggagaat aagcctttca tcccgaagaa aaagccgccg aagatgactg 1583401 caagcgcgat ggccgcgata aaagtaatag atacaattcc gattaatttt gatctcaggt 1583461 taaaatcttt agagtgctcg ttctgttctt tttggttcat gtatgacact cccttcacct 1583521 gcttactcat acaaacagca cccttgaatc agcccaaaat atctataagt ctgttttctg 1583581 acgaaaatag tatagcatat tttaacaaaa ccaaaaaagg ccctttccac tggggaaggg 1583641 cctttttcat catgttaact cctgagattc gccgaagctt tctctttttt tggccaaata 1583701 aaatagctgg ctgtaatgag aaagtcaatg cctataatga cagtccacag tttaagaatg 1583761 ccgctcaacg cctcggttcg ggaagagtca ttgataaaat agatcatccc tgccaatagt 1583821 cccgcaccaa ttaagtaggc cagcacatgt cttagccagc ctttcgcacc gtgcttggca 1583881 tggtccattc caaaacgttt cagcggtttt gttccttttt ttgtcacata atattgaaac 1583941 ttttcatctg cccattgaat catttgtttc ccataagcga tcgatatacc gatgtaaaca 1584001 gctgcaatcc catgggctgc ggtcgctgag gctccgcggt aaaggtccac accagttgcc 1584061 gctaacaaga tcaaatcgat aactggagtt aaggcaagga atagcagtcc taatgtatgt 1584121 cgtttgaata cgtagcgtac agcaagcccc aaaacaatga caacccaaaa cgcaatttca 1584181 cagaaaacaa tcatccatgc gataccgttc aatccattcc cctcttttca atacagttgt 1584241 attatttaaa taatatgtta ccatctttgt ttttgtaaca caactgtatt ataaaaattg 1584301 ccccgccttt gaacgaaagc tcaaaggcgc tacgctgtat tattttgatg aaagtggctg 1584361 tcagctgtgc tggatatcaa ttgtatatac tgcacgatct gttacgacct tcaatccttc 1584421 gttttcttgg tgaatatgaa gctcacctaa taaaggaatc tcataggcat tttgcggaag 1584481 cggtacgttt ccgtcctcag tgaatgttgt tccttcgcct tctaaaacaa gctcttcttt 1584541 cgcaacataa tcatcaggat gattcgtact gcgtatagcc actttttgaa ggtggagaac 1584601 aatctgatcc aagtctgata tctcttcatc atgggtcaat tcaccttttc taatatcaag 1584661 cgtctggccg acttttgatt ccagccattg agaaagctgt gtattcgtgt gtgccatcaa 1584721 tattcctcct tttgatctac acgatactat tcccaattgc tgcatctttt acacgggaaa 1584781 gagccgcccc actctttatg tatgaaacag ttcgctgttg agtgccttga tatagcgtac 1584841 ggcagaacgc tggaccgatt cgtcggcatt ttctttgaca actttagaga aagcattgta 1584901 aagccggttg aattgaagcg gttttacttt ggctgctatt tcttcaactt tggaggcggg 1584961 aaggggaatg agatttgggt agctgtacat aaagctgacc cagtttcgat ccgccgcaac 1585021 cgtaatgata tctccggtca atagacagcc tttcccttca ttgcccttgc tccaatgcaa 1585081 aacagcaccg cctttaaaat gtccgcccag tcggtaaagg tccagtcccg gcttcatatt 1585141 gagcgtttcc cctgaccaga agtgaatgtg attgcttggc cttgtcaccc attctttatc 1585201 atcctcatgg atatagatcg gcgcctgaaa cgcttcagcc cactcaacct gagtagagta 1585261 ataatgtgga tgagacaagg cgatggcttg aataccgcct aattcgttga tttggtcaat 1585321 tgtcttttgg tcaagatatg tcatgcaatc ccacagcaca ttgaagccct tatgctgaat 1585381 aagatgggct gtttgtccaa tcgcaaactc tggttcagtt ttgatgctgt aaagatgctc 1585441 ttcttccttt ttaaggatgt tttgaaggtt tcctttctca cgcatgtctt caagggttgt 1585501 ccaagtttgt ccatcgggat gaatatactg tctttcatcc tcgcaaatca gacacgagtt 1585561 gggcggatct acagtctgtg catgttgcac accgcatgta ttgcagatat aatatggcac 1585621 tttcttcact tccttcatct attttccatt attttacctt atgattatga atattcaaac 1585681 gaaaaaaccg gcagttctgc tgagagagaa ttgccggctt ttgatgatgt ttattggccg 1585741 ggaacggaat tttctgcgtt gacagcgccc gctccgtaga tattcggatc ttcatctttc 1585801 catttgtccg tgccgttttt caaaagctct tttacttcat caggggtaag atccgggttt 1585861 tgctgaagaa ttaaagctgc gattcctgcg caaatcggtg ttgccatcga ggttcctgac 1585921 attgtaaagt actgagaccc tacacggctt gacttttgga gcttatcaat ataagaattc 1585981 ggagagcgaa gggaaataat attaacaccc ggcgctaaaa tatcgggctt ttctttcccg 1586041 tatactgtcg ggccgcggct tgagaaggaa gcgacagtat catcatcgct gcttgcagta 1586101 ttgttatcgt caagcgcacc tactgtaatc accttttcgc tcacgcccgg gcttgcaatg 1586161 gtctgcgaat cagggcctga gtttccggca gcgacacaga cgacaatccc tgcgctccac 1586221 gcttcctcaa ccgctctgac taacggatct tcctgttcat gatcatatct aagggcatcg 1586281 cccccgagcg acatgctcat aatatcaatc ggttcatcgg ggttgtcctc attgtattga 1586341 atacaccact caacaccctc tataatatct gctaacgttc ctgaaccctg cttgtttaat 1586401 acctttacgc cgatgagatt ggcttccggt gcaggtccgc ggtattgacc ggaagaggat 1586461 gcaccgctgc ttgcgacatc acctgcacag tgtgtgccat gaccattatc atcgtacggc 1586521 tctgtttttt gattgaccat gtccgcgaat ccgataattc ttccttctag atcaggatgc 1586581 gggtagattc ctgtatcgac aacagcgaca gtaacacctt ttcctgtcag ggtttgcccg 1586641 tttctgacga cttccttcgc atggcttgct tcggttgccg tgtctaaaag cgctttgact 1586701 tcgcggttta aatacacttt acggatattg ctgcattcag agagaaggga atgtaatgct 1586761 gaaggagtaa cctcggcgct gcagcagttg attttgttga agcggctttt tagcttgctg 1586821 cgtttttctt tttgcagcac ctctccagcc atttgaaagc cggtctcgtg acagccttcc 1586881 tcaaattcga taatgactga catttttttt ctgttttgca atttggtttc gaaaaattta 1586941 tgcaagaagc aaggagtcca tttgaagggc ttgtaaagtt gcaatacggt ttcccgtaac 1587001 ggccaatcta gcttgtgagc atttgctctc accatttgta ccatagagta cccaaacatg 1587061 tattttcctc ctattataag gttctctgta tactctatga acagatgata ggtttggtaa 1587121 gtttgtttgt cctctgtaag agacagacaa gagtttgttt ttctgaatct ttcgcattag 1587181 atacgataga ttcagaagct gaggaaatca ttggggattg aaaaagaacg tttgttcgta 1587241 ttataatgtg atcatatcaa actgggaagg ggagagcaac cgtatgaatt tctacttgca 1587301 ccgatctttg gaaagccaaa tgccaatcag cattatatat gaagaaagac ggaacgatta 1587361 gtaaaagaac gattattgtg agacagaaaa gcaaaacgaa aatcaaagca ttttgttttt 1587421 cgaaacaaca gatcagaaca tttttattgg actctatcct ctcctgtgat tttgtgagaa 1587481 caaataagca aaatctctat tctgcaggcc ggtaacagct gtccgtctca gcaaccgggc 1587541 agcctgttac taaaaccctc cttaaaccta tatacattta tttgccaagt gaggttgttc 1587601 ctaccttttt tgtctttcct ctcaaccttt tttcactctt atttgaaatg aaccgctaat 1587661 aaccgtgaca atcaattgat tttttgaaac cgggaacttt ttcactgatg atattgtgta 1587721 tacaatggta agataaaacc tattggctaa acctcatata atgaaccgcg ccattcttat 1587781 gaaaggagtt aaacatgaga agatttttac taaatgtcat attagtctta gccattgtct 1587841 tgttcttgag atatgttcat tactcattgg aaccagaacc atcaaatcag ccagatacat 1587901 attcaaattt cagcagcttg gcagagaatg agagcccagc cgattacgat atttcatata 1587961 atgagaaaaa aggaagcaaa gtcttaatta tgtctccgca tggcggaaga attgaaggcg 1588021 gagtaagtga gcttgtgcgt tatttcaata atgaatactc tacataccta tttgaagggt 1588081 tgaagtccca tgataaccaa acactgcaca ttacaagcac caactttgat gagccattgg 1588141 caaaaaagaa aatcaaggag catcaatatg tggtggcttt tcacggatat aaaggagaga 1588201 acaagaatac ccttgtaggg ggaacagacc gaaagcgggc gaaaatgatt gtgagagccc 1588261 ttgagcggag agggttttcc gctgagttag cgtcgtctaa aagcggtctt gctggattga 1588321 atgccgaaaa cattaataac caaggggaaa cggggctaag tatccagctg gaaatcagcc 1588381 gtgagcagag agaagcattt tttgatgatt tttattataa aaatagaaaa tacacaaaga 1588441 acagtgaatt ttatgcttat gtcagtgcga tcaaaggtgt cctggaaaaa gagtattcgt 1588501 aacaagcaga tcagaagaca aaataagaga agatcagtag actgaaatag gataaaaaag 1588561 gaggcaaaac aatggcagat catcattttt atttaaaagc gaactggccg ggtaaccgta 1588621 atgatgtcgg tacgatcgaa agcggaaacc tgatcacatc gatttccatt cctaaagaaa 1588681 tggatggccc gggagaaggg accaacccag atgaaatgct tctcggggcg gcagcgacct 1588741 gttacattat tacacttgca gcgatgatgg agagaagcgg gctggaaaaa gaagacttac 1588801 agatggagtc agaaggcatt gtcaacgtta caaaaggagt ctttacatac aaaaagatca 1588861 ttcaccgtcc ctctgtcgtg cttaaacatg atgcttcaca agacgacgtc gcattggcgc 1588921 acaaactttg taaaaaagcg gagtcgtcat gcatgatttc gcgtgcaatt caaggaaatg 1588981 tcgagctgca gcttgaagcc tctgtgaaac tgggtggaga ataaagaaaa cagacggtca 1589041 ctcacaggcc gtctgttttt tatcttcagc gtgggctttc gattgattta gcacgaccac 1589101 gcctgcaatg acaagcgtga gaccgaatac accttttaaa ctgatggttt cgccaaaaag 1589161 caaaaacccg acaattgctg taagcgcggt accaacgccc gaccatgttg catacgcgct 1589221 tgataagtca attgttttta aagaaaagct tagaaacgta aaagcagaaa gaaatccgac 1589281 tatgactccg gcaatgggcc aggcttgtgt aaatccttct gaaagcttca acatcgtgct 1589341 cccaaacact tcagatacaa tggcgagagc caaataaagc aatcctctca tcttcatcac 1589401 tcctttacgg ccaattaagt aacacgaccc ctgatagtaa taaaagaatc ccgataagcc 1589461 ctttggcatt cagatcttcc ttgaaccatt ttactccgat cactgtcgtc agcaccgtgc 1589521 ctgccccgct ccaagtcgca taggagaggc tcaggggaat atggtttaaa gtcagggaca 1589581 gcatataaaa ggcgagggaa tagccaataa cgaccaaagc acttggcttc cactttttga 1589641 agccatcaga tactttcagc atggctgctc ctatcgattc cgaacatatg gcaatcgtga 1589701 ggaatatata tcctatcaac atcatgaatt ctcctcacta tatttttaga ttagaaaaaa 1589761 aacttcagct agaaaaatat tagtgtatgc ctatgtatga gtcaagagat tcattttcac 1589821 acacttaaaa agaccccttt ttaaggggtc ttttgcgttt aataataaaa agggaacggg 1589881 gcatacggat aataggggta tccgccatac aaataaggat taaataaagc gcttcctata 1589941 agcccgcctg caaggccgcc gataaacggt cctccaaaaa atccgaatgg ccggccaaac 1590001 ccataaccaa atccgggtct tccaaacccg taaccgaacc cgaacggtct tccaaaccca 1590061 aatggtctcc cgaatccgaa cggccttcca aatattcttg tatcttcagg gctgaaatgc 1590121 tctaactcgt tcatgttttc tttcctcctg taataaagtg tagatgatgc agtgtattca 1590181 ccctgcccgg atttgattgg gcgaatcgag gaaaaggagg atgtgaacac attgggcctg 1590241 tatcagtctg actggtcaaa agcaccgccc cacgcacatg cttatcatgt caaaacaacg 1590301 agagaacagg gccattatca tctcatcgaa gggtttactc agccggcaaa cggatcaaat 1590361 accgatcagc atacacatta ctatacaggg atcacttcat ttgaaaacgg ccattttcat 1590421 cggtattacg gaatctcagg accggcgatt cccttagcag atggcacaca ttatcatgaa 1590481 atcgaagaaa cgacgtatct ggcctataac gagccgattg agatccagta cggaggggtt 1590541 gtgtacgatc ccggagatga cagaagaaaa acgcatcgtc ataccctgaa aggaaagaca 1590601 agggaaattg tcggcaatga gccgctcggc tggtagaagg atgtttaccg atgcaaaaaa 1590661 agggcaaaat ggataggtgg ttgtccatgt tgaatgctat aatgggggga gatttataaa 1590721 agagagtgat acatattgaa taatacgaag cagcccgttg tcattttagt cggaccgacg 1590781 gcagtgggga aaaccaattt aagtattcag ctagccaaat ccttaaacgc ggaaattatc 1590841 agcggagatt cgatgcagat ttataaaggg atggatattg gaacagctaa aattaccgaa 1590901 caggagatgg agggagtgcc ccatcatctg attgacattt tagatcccca agactctttc 1590961 tctactgccg attatcaaag cttagtaaga aataaaatca gcgagattgc aaatagagga 1591021 aagcttccga tgattgtcgg cggtacaggg ctttatatac aatctgtgct ttacgattat 1591081 acatttacgg aagaggcaaa tgatcccgtg tttcgagaga gcatgcaaat ggctgctgag 1591141 cgggaaggcg ctgactttct tcatgccaaa cttgctgcag cagatcccga ggcagcagct 1591201 gcgattcatc cgaataatac aagaagagtc attcgcgcac tggaaatttt acatacgtcc 1591261 ggaaaaacga tgtcccagca tttgaaggaa caaaaacgag aacttctgta caatgcagtg 1591321 ttaattggcc tgacaatgga tagagacacg ctttacgaaa gaattaatca gcgggtcgat 1591381 ttgatgatgc agtcaggcct tcttccggaa gtgaaacgct tatacgacaa gaacgtgaga 1591441 gactgtcaat caatacaggc gataggctat aaagagctgt atgcatattt tgacggtttt 1591501 gtgacacttt ccgatgctgt cgaacagcta aagcagaact cgaggcggta tgcgaaacgc 1591561 cagctgacgt ggtttcgcaa caaaatgcag gtcacatggt tcgatatgac accgcctgtt 1591621 gatatggagc tgaaaaaaaa ggaaattttc acacatatag caggaaaact cgaactttaa 1591681 tcgaaactgt atgatataga gaatcaagga ggacgaaaca tgaaaccgat taatattcag 1591741 gatcagtttt tgaatcaaat ccggaaagaa aatacgtatg tcactgtttt tttgctgaac 1591801 ggctttcagt tgcggggcca ggtgaaaggc tttgataact ttaccgtatt gttggaatcg 1591861 gaaggtaagc agcagcttat atataaacat gcgatctcaa cgtttgcgcc gcaaaaaaac 1591921 gtccagcttg aactcgaata gatcaaaaaa tgccatgtca agacatgagg aaaggctgtc 1591981 gggggttccc ggcggccatt tttaacatga atccactttt gctccaagct ttttgtgtaa 1592041 gctgaccatg ccaaggcacg gtcttttttt atgagaacaa catacggaag taaaaatggt 1592101 atattatgta taaaatgaat ttgggagtga tcgatcttgt ttgaaagtga agcagaactg 1592161 agacgaatca ggattgcact tgtatggata gctgtctttt tactgttcgg ggcgtgcggg 1592221 aatcaagata ccattattga aacagacaac ggcaattcag actatgaaac gcctcagccc 1592281 acctcgtttc cacttgaaca taaccatttt ggcgttatgg aggacggcta tatcaaaatt 1592341 tatgagtata atgagtcccg caatgaggta aagctgaaga aagaatacgc ggatgatgag 1592401 cttgaataaa attcacaagc attcgaattt acaaagcgga tgccagccgc taaactaaat 1592461 acagacacag atcaaacaga gggtgaaaac atgaagcata aagtgatcgt gaatcattgg 1592521 gaagaaattt gcgaagatga ttcttgctat gaatacggaa caagtatcat tgtgaacgga 1592581 aaagaattaa tcagagaagc gtcaattatc actgctttga aggcggtttt agaagagatc 1592641 ggcgcggatg ttgaaataga agaaacagta gagagcgaaa aatgctgtga tagcttaaga 1592701 aaaaaaaatc tagactacta agcagttttt tttcatgtta tgatatacat cggctaaaaa 1592761 cgacaccccg agtaggacga gagatgattc tcgttctgct ctcttttttg ggccctaatg 1592821 agtctgcccg tttgcctgat ttgatcaaaa tatgaatttt tcataaaaac gaatctatat 1592881 attgtgtttt tgctagaggg tagtatacta tatatagtgt tagtgatgag agattcatat 1592941 tttttgatag gtcgtgataa aacgtggtac aaatcatatt tgattcgaaa acagggaatg 1593001 ttcagcggtt tgtgaataaa acaggctttc agcagatacg caaggtggac gaaatggacc 1593061 acgtggacac tccgtttgtt ttggtcacct acacgacaaa cttcggccag gtaccggcat 1593121 caacacaatc atttctcgaa aaatacgccc atctcttatt gggagtcgct gcgagcggca 1593181 acaaagtatg gggcgataac tttgcaaaaa gcgccgatac catttcaaga caatatcagg 1593241 tgccgatctt gcacaaattt gaactcagcg gcacatctaa agacgttgaa ttgtttactc 1593301 aggaggtaga aagagttgtc acaaaatcaa gtgccaaaat ggatccagtt aaataacgaa 1593361 atcatgatcc aaaaagatgg gaaattccag tttgataagg ataaagaagc tgtacatagc 1593421 tattttgtag attatatcaa tcaaaacaca gtcttctttc acaatttaaa agagaagctg 1593481 gattatttgg ttgaaaacca atactacgaa gaggaattct taagccttta ttcttttgaa 1593541 gacattaaag aagtgtttaa gacagcttac gctaagaagt ttcgttttcc ttccttcatg 1593601 agtgcgttta aattctataa tgactatgct ttgaaaacga atgacaagaa aaaaatcctc 1593661 gagcgttatg aggaccggat ctcaattgtt gcgctgttct tcgctaacgg cgacactgag 1593721 aaagcaaaag aatatgtaaa cctgatgatc aatcaagaat atcagccgag cacaccgaca 1593781 tttttgaatg ccggcagaaa acgccgcggt gaacttgtga gctgcttctt gctcgaagtt 1593841 aatgattctt taaatgacat ttcaagagca atcgatatct ccatgcagct ttctaagctt 1593901 ggtggcgggg tttctcttaa cctgtccaag cttcgcgcga aaggtgaagc cattaaagat 1593961 gttgagaatg cgacaaaagg cgttgtaggc gtcatgaagc ttcttgataa cgcgttccgt 1594021 tacgctgacc aaatgggaca aagacaaggc tccggcgcgg cgtatttaaa cattttccac 1594081 cgcgatatca atgattttct tgatacgaaa aagatttctg cggatgaaga tgtgcgtgtc 1594141 aaaacgcttt cgatcggtgt tgtcattccg gataagttcg ttgagcttgc acgcgaggac 1594201 aaagcggctt atgtattcta cccgcacacg atttataaag agtacggcca gcacatggat 1594261 gagatggaca tgaacgaaat gtacgacaag tttgtcgaca accctcgggt gaaaaaggaa 1594321 aaaatcaacc cgcggaaact gcttgaaaaa ttggcgatgc ttcgttctga atcaggctat 1594381 ccatacatca tgttccaaga taacgtcaat aaagtgcatg cgaataacca tatttccaag 1594441 gtcaaatttt ctaacctttg ctctgaagtg ctgcaggcat ctcaagtttc ttcatacaca 1594501 gactatgatg aagaagatga aatcggtctg gatatttcct gcaacctggg ttcgcttaac 1594561 attctcaatg tcatggagca taaatcaatc gaaaagacag tcaagcttgc gacagactct 1594621 ttaacacacg tgtctgaaac aacagacatc cgtaatgcgc ctgctgtaag acgggcaaac 1594681 aaagcgatga aatcaatcgg cctcggtgct atgaaccttc acggctacct tgcgcaaaac 1594741 ggcattgcgt atgaaagtcc ggaagcgcgt gactttgcaa acacgttctt tatgatggtg 1594801 aatttctact ccatccagcg ttctgcggaa atcgcaaaag agaagggcga aacgtttgat 1594861 caatatgaag gatcaaccta tgcgacaggt gaatacttcg acaaatacgt ttcaactgat 1594921 ttctcaccga aatacgaaaa aatcgctaat ctgtttgaag gtatgcatat cccgacgaca 1594981 gaggactgga aaaagctaaa agcatttgtc gctgaacacg gtatgtatca cagctacaga 1595041 ttatgcattg cgccgacagg ctctatctca tacgttcaat caagcacggc gtctgttatg 1595101 ccgattatgg aacggattga agaacgaaca tacggcaact caaaaacgta ctacccaatg 1595161 cctgggcttg catctaataa ctggttcttc tataaagaag cctacgatat ggacatgttc 1595221 aaggttgtgg atatgatcgc cactatccag cagcacattg atcagggaat cagctttaca 1595281 ttgttcttaa aagacacaat gacgacccga gatttaaacc gaatcgatct gtatgcacat 1595341 catagaggaa ttaaaaccat ttactatgca agaacgaaag atactgggca agacagctgc 1595401 ctttcttgtg ttgtttgatt aaaggagagt ttatagtgac aaaaatttat gacgcagcaa 1595461 actggtcaaa gcatgaagac gattttaccc aaatgttcta taaccaaaac gtgaaacagt 1595521 tctggcttcc ggaagagatt gctttaaacg gcgatctcct cacatggaag tacctcggaa 1595581 aaaatgagca ggacacttat atgaaggtac tggccggact tacgcttctt gacacagagc 1595641 aggggaatac ggggatgccg atcgtggctg aacacgtaga tggccaccag cggaaagcgg 1595701 tgctgaactt tatggcgatg atggagaacg ctgtccatgc gaagtcgtac tctaatattt 1595761 tcatgaccct tgcaccgact gaaacgatca atgaagtatt tgaatgggtt aaacaaaata 1595821 aatatttgca gaaaaaagcg caaatgattg tcgggcttta caaagccatt caaaaagatg 1595881 atgaaatttc actgttcaaa gccatggttg cttccgtcta tctggaaagc ttccttttct 1595941 acagcggttt ctattatccg ttatatttct acggacaagg aaaactgatg caaagcggtg 1596001 agatcattaa cctgatcctt cgtgacgaag cgattcacgg cgtgtatgtc ggtctccttg 1596061 ctcaggaaat ttataataaa cagacagaag agaaaaaagc agagcttcgt gaatttgcga 1596121 tcgacctcct gaatcagtta tatgaaaatg agcttgagta tacagaggac ttgtacgatc 1596181 aagtcgggct ctcacatgat gtaaagaaat tcatccgcta taatgcgaat aaagcgctga 1596241 tgaaccttgg atttgatcca tacttcgaag aggaagacat taatccgatc gttttaaacg 1596301 gattaaacac aaaaacaaaa tcgcatgact tcttctctat gaaggggaat ggctataaaa 1596361 aagcgacagt tgagccgctc aaagatgatg acttttattt tgaagatgaa aaagagcaga 1596421 tataatatct gctcttttcg gcttgaaggt tcaaatgagg aggacgcagt acccatggga 1596481 aaaatggacg aaatgatttt agttgccccg cgcgatgatg tgtttaaaaa agaaagctta 1596541 accttccagg gcgtgtacag tgaagatagc agagtagcag aaatcatggc tcagattgaa 1596601 gcggcctatc gtgaaatgag aagaggggac gcagaagaag atccgcgttt caagcagccg 1596661 ataccttatg tcgtcattaa gcgtgaagat gaagtttttc tttacgagcg gctggctggc 1596721 ggcggtgaat cacgtctgca caacaagctt tctctcggtt ttggcggcca tatgaacgcc 1596781 atcgaagggg cagcttcatt tgctgaagtc ttaaagctga acacagaccg tgagcttgag 1596841 gaagaactgc aaataaatga agaagataaa caggcgattg tcacactggg attgatcaat 1596901 gatgatgaaa acagtgttgg caaagtgcat atcggtattc tttctgcgct tcaattaaag 1596961 cctggcgcac aagtggaagt gaaggagaaa gaacaaattg cgggtaaatg gatgaaagtt 1597021 tctgaattaa aacaggatga tatctacaac cgtctggaaa catggtcaca gtttgttgtt 1597081 gatattcttg aataaaaaaa cccggtttct cgcgatgagg agccgggttt ttttatgaga 1597141 cgctcgtccc cgtctcggct atgattctag gatcacaata gcgtcaaagc cggcattttt 1597201 cgctctggca gcgagggtgt ctgcattgtc tttggatgaa aatgcgccaa tctgcacttt 1597261 gtataatccg tcctttaaaa ggacaatcga gtcaaaacct ttggcttcgg cattacttgc 1597321 gagcgagtcg gcattcgctt tgactttaaa tgcgccgatt tgaaccttat ataaccctga 1597381 gctggaagtc tttttaaggt taaaggcttg ctccagcccg tttgcatgtc ctctcgctaa 1597441 gctttgaata aaactgctcg ttttcagctt atttgcatcg gaaacggtat caatgaagcc 1597501 gttctcggtc aagagggcag gcattgccga ctcccttagg acgtggaagt tcgctgtttt 1597561 tttgccgcga tcggcaaagt cgacagcttg tatcacttca gagtgaattg tcgattgata 1597621 agtcgtcgtc ggggctccta catctggata aatatagctt tcaaaacctg tgcctccccc 1597681 ggaattaacg tgaatggaca aaaagaaatc tgctccccag ttatttgcgg catttgtccg 1597741 gtcgtttaag ctgacatatt ggtcgcttgt ccggctcagc agcagagaaa cgccttcata 1597801 ttcattagtt aatatcgtac gtaaggctaa agcgatttgc agggttaacg ttttctcctg 1597861 aaggccatta cctgttgcgc ctggatcaga cccgccatgg ccaggatcaa taaaaatttt 1597921 aaccattttt catcacctca ttacaggata tgaaaaaaca cggcttctgc ttgtacgatt 1597981 atcattcaac tgaaaaatga ggaaataacc ctttcacatc cagaaattat ttctcgggaa 1598041 agcgcacaat tcaacatgaa gcgacaacag atacggtccg acatgaaatc tgtgcatacg 1598101 ccatatgttt gtatgtacta tgggttcggt taacctgcac tgattcctgc tggttttaag 1598161 ctttgcgttc atattaaatc aagcatttaa aacgtaaatt gatgaggaaa gctcctttca 1598221 ttaaagacac cgctttataa atcgaaaaaa agaaaaacac ttcaggtatc ttagggcggg 1598281 taatacgttt cgtacaaaaa tcagcccgtt gtatgaaaaa gaaataatga gaaagaagct 1598341 cactataata ctctgacaaa atgattaaaa acaaaatctc atggtttgtc caccccatgt 1598401 ccgtgaatac aataagaaat aaagtatttc tcgggaaagc gcaggattcc ttattgttcc 1598461 cgaaaaaagc aattgtttcg acacatgata ggcgtttgtc acaatcggca tccgcttgaa 1598521 tatcatatag agagaacaga gaggtgaaga tgttggagcg cgctgtgact tataaaaaca 1598581 acggacagat caacattatt ctgaacgggc aaaagcaggt gctgacgaat gctgaggcag 1598641 aggcggaata tcaggctgca ttgcaaaaaa acgaagcaaa gcacggcatt ttgaaggaaa 1598701 tcgaaaaaga gatgagcgca ttagttggga tggaggaaat gaaacgcaac atcaaggaaa 1598761 tatacgcctg gatttttgtg aaccaaaaac gcgcggagca aggcttgaag gttggaaagc 1598821 aagcgctgca catgatgttt aaaggaaatc cgggaacggg aaaaacgacg gttgcacggc 1598881 tcatcggcaa gctgttcttt gaaatgaatg tcctgtcaaa aggccactta atagaagcgg 1598941 agcgggctga cctggtcggg gagtatatcg gacacaccgc ccaaaagacg agagatttaa 1599001 tcaaaaagtc attaggtggc attttgttta tagacgaagc ctactcgctg gcaagaggcg 1599061 gcgaaaagga ctttgggaaa gaagcgatcg acacacttgt aaagcatatg gaagacaaac 1599121 agcatgagtt tattttgata ctcgccggat attcacggga aatggatcat tttctctcgt 1599181 taaatcccgg actccaatca agatttccca tctccattga ttttccggat tactctgtga 1599241 cccagctcat ggagattgcg aaacgaatga tcgatgaaag ggaataccag ctcagtcaag 1599301 aagcggaatg gaaattgaaa gattacttaa tgacagtgaa aagcacgaca agtcccatta 1599361 aattcagcaa tggacgtttt gtcagaaatg tgatcgaaaa atcgatcaga gcacaagcca 1599421 tgaggctttt aatgggagac caatacttaa aaagcgactt gatgaccatc aaaagccaag 1599481 atctttccat taaagaagaa gcatctggat ctgcatagac ctctcagttt ttgagaggtc 1599541 tgttttttgc tcgtatttcc gcttttcaaa gcaatcgatt tgtggtatac acatgcaggg 1599601 tttggtatga taatactact gcccaatatg caaaagaaag gaacatccat ttgaacgaac 1599661 aagaaacgat tcaggagaaa gccattttag tcggatgtca gctgccgcat atcacggatg 1599721 agcattttga aaattctatg gaagagctag catctctgac gaaaacagca gacggaaaag 1599781 tactgaccag cgtcacacaa aaacggaaca gggctgacgc cgctacatat ataggaaaag 1599841 ggaaggtaga agagctgaag gcactcgtgg aagagcttga agctgatctc ctcatcttta 1599901 atgatgaact gtcgccaagt cagctgaagt cattggcaac agcaattgaa gtgaagatga 1599961 ttgaccgcac gcaattgata ttagatattt ttgcaaagcg ggcgagaacg agagaaggca 1600021 aacttcaaat tgagctggct cagctgcaat atgcactgcc gcgtctgacg ggacaaggga 1600081 tcaacctttc ccggcaaggc ggaggaattg gggcaagagg tcccggggaa acgaaactgg 1600141 aaaccgaccg ccgccatatc agaaatcgca ttcatgaaat caacacacag ctttccactg 1600201 tcattcgcca tagaagccga taccgtgaaa gaagaaagaa aaacggtgtg cttcaaattg 1600261 cgcttgtcgg ctatacaaac gcagggaaat caacatggtt caaccgcctg acgagtgctg 1600321 acagctatga agaagacctc ctgtttgcca cgctggaccc gatgaccaga aaaatggtcc 1600381 tgccaagcgg ctacagtgtt cttctttcag atacagtagg atttattcag gatcttccga 1600441 cgacattgat tgctgcattc cgctcaacgc ttgaggaagt aaaagaagcg gatttaattc 1600501 tgcatttaat tgattcttca aatgaggatt atgcgggaca tgaaaaaaca gtgcttcggc 1600561 tgcttgagga gcttgaagca gatgatatcc cgatgctgac ggcttacaat aaacgtgatc 1600621 aaaaactgcc tgattttata ccgaccgccg gaagggatca cattatggtc agtgcgaaat 1600681 ttgaggacga cgctgcagcc tttaaagaag cgattcagcg ctatttgcgc caagaactgt 1600741 taacgtcttt tgaagcacat gtgccggcaa gtgaagggaa gctcctttcc agaatcaaat 1600801 cggaaacgat ggtagaccgc ttctatttta atgaagaaaa tgaacagtat gacatatccg 1600861 gctatgtcca agaagagcaa agtatcatcg gtgaattaaa gaagtatatg taggaaggaa 1600921 atataaagac atgtttgaca cattaacaca cggagaatta ttgaagaaaa cggcaatgga 1600981 agtggaagcg gacattgccg gcattcataa acaaatagaa gaaatcagcg agcgaaatga 1601041 gtggagagtg cttcaaagct atagaaaaca caaagtaagc gacactcatt tcacgccgtc 1601101 tactggatac ggctatgatg atatcggaag agacacgctt gaaagcatat atgcggatgt 1601161 gtttggcgga gaagcggggc ttgtaaggcc gcaaatcatt tcaggcacac atgccatctc 1601221 aattgctttg ttcggtgtcc tcagaccggg ggacgagctc ctttatatca cgggcaagcc 1601281 gtatgatacg ctagaggaaa ttgtgggcgt caggggtgga gaaaacgctg gttcgttaaa 1601341 ggattttcaa atcggctata atgcggttga tctgacgaaa gacggaaaga tagactatga 1601401 tgcagtcgcc gctgcgatca atccgaagac aaaagtaatc ggcattcagc gctcaaaagg 1601461 atatgcgaat cgcccttctt tcttaattag tgaaataaaa gaaatgatcc gttttgtaaa 1601521 agaaatcaat gaaaatctga tcgtctttgt ggacaactgt tacggagaat ttgtggaaga 1601581 gcttgagcct tgccatgtcg gagccgacct gatggcggga tctctcatta aaaatcccgg 1601641 cggcggcctt gcgaaaacag gcggctacct cgtcggaaaa gcgaaatgga ttgaagcttg 1601701 ctcataccgt atgacgtcac ccggcatcgg cagagaagcg ggggcatctc tttactcgct 1601761 ccaagaaatg taccaaggct tctttttggc gcctcacgtt gtgtctcaaa gtttaaaggg 1601821 agcggtgttt acagcgagat tccttgaaaa actcggcttc acttcaaacc cgaaatggga 1601881 tgcgaaaaga acggatttaa tacaatccgt tgagttttct gacagagaaa agatgattgc 1601941 tttttgccag gctattcaat ttgcatcgcc aatcaatgct catgtgacgc cttatccagc 1602001 ctacatgcct ggatacgagg atgatgtcat tatggcagca gggacgttta ttcaaggagc 1602061 aagcatcgaa ttatcagctg atggccctat ccgcccgccg tatgtagcgt atgttcaggg 1602121 aggattaacc tattcgcatg tgaagaatgc catatgcagt gcagtggatt cattgatgca 1602181 aaagcaatta atttaaattt tttaaaaatt tctctggatt tgatgttaag aatccttaca 1602241 tcgtattgac acataatata acatcaccta taatgaaact aagttaagaa aaggaggaaa 1602301 ttgagatgag tgataatatt cgccgctcaa tgcctttatt tccaatagga attgtcatgc 1602361 agttaactga gttatcagca agacaaattc gatattatga ggaaaatgga ctgatatttc 1602421 cagccagaag tgaaggaaat agacgattat tttcatttca tgatgtagat aaactgttag 1602481 aaatcaagca cctgatagaa caaggtgtaa acatggcagg aattaaacag attctggcga 1602541 aagccgaagc cgagccagaa caaaaacaaa acgagaagac gaaaaaacca atgaaacatg 1602601 atctgtccga tgacgaactg agacagctcc tgaaaaacga gctcatgcaa gccggccgtt 1602661 ttcaaagagg gaatacattc cgtcaaggcg acatgtcccg cttctttcat taatccgtta 1602721 gcaactgttt tgctatatac atttaccttt taagaggagg aattttacca aatggcaaag 1602781 tacactagag aagatatcga aaaattagta aaagaagaaa acgtgaagta tatccgcctt 1602841 caatttactg acattcttgg aacaatcaag aatgttgaga ttcctgtaag ccagcttgga 1602901 aaagcgcttg ataataaagt catgtttgac ggttcttcta ttgagggatt cgttcgtatc 1602961 gaagagtcag acatgtacct gtatccagat ctaaatacat ttgttatctt cccatggaca 1603021 gctgaaaaag gtaaagtagc acgtttcatc tgtgatattt acaatccgga tggcacacct 1603081 tttgaaggtg acccgcgaaa caacttaaaa cggattctga aagaaatgga agacctcggc 1603141 ttcagtgatt ttaaccttgg gcctgagcct gaattcttct tattcaaatt ggacgaaaaa 1603201 ggcgagccga cgcttgaact aaacgacaaa ggcggatatt tcgacttagc tccaactgat 1603261 ttaggagaaa actgccgccg cgatatcgta cttgagcttg aagagatggg ctttgaaatc 1603321 gaagcgtctc accacgaagt agcacctggt cagcacgaaa tcgactttaa atatgctgga 1603381 gcagtccgct cttgtgatga catccaaaca tttaaactag ttgtcaaaac aattgcccgt 1603441 aaacacggcc tgcatgcgac atttatgcca aaaccattgt tcggtgtaaa cggttcaggt 1603501 atgcactgca atctatcact cttcaaaaat ggtgttaacg cattctttga cgaaaacgca 1603561 gatcttcagt taagtgaaac agcgaagcac ttcattgcag gtatcgtgaa gcacgcaaca 1603621 agctttacag cagtaacaaa cccgacagta aactcttaca aacgtcttgt tcctggctat 1603681 gaagcacctt gttatgtagc atggagcgcg caaaacagaa gcccgcttat ccgtatcccg 1603741 gcttctcgcg gcatcagcac acgtgttgaa gtacgcagtg tagacccagc tgcaaaccca 1603801 taccttgcac ttagcgtatt gcttgctgca ggattagacg gaatcaaaaa caaactggaa 1603861 gcgccggctc caatcgaccg caacatctat gtgatgagca aagaagagcg catggaaaac 1603921 ggaatcgttg accttccagc aacacttgcg gaagcactag aagaattcaa atcaaacgaa 1603981 gtcatggtca aagcgctggg cgagcaccta ttcgaacact tcatcgaagc aaaagaaatc 1604041 gaatgggata tgttccgcac gcaagtacat ccttgggaac gcgaacagta tatgtctcag 1604101 tattaatatc tcaatccctt ggcactaaaa gtgtcagggg attttttatg ttaataggta 1604161 ataaattatg gagcggcata gtgtttaaca cagccattaa tcctcagaca gtcaaatagc 1604221 catttctact ccggttgaaa gcttctctat ttttgcttct tatttatctt tcctgtattg 1604281 atatatgtat gtagggttgg acttataaca taaactattc tggccattcc gttctttcaa 1604341 ttcatgaccg ggcttgccat cagcataaat ctaggctaac agtctccata catcctgtga 1604401 tcacctttat caaactctta aatgcaactt accactaacc aattctttat ttcgcataga 1604461 tcatctttgt catgtgttta cacaagaatc tgttttggac tgagacactg aatataacaa 1604521 aacagtcaaa aatcaatatt taattcattc tgtttaaact ttctgaaaaa gatgttgaaa 1604581 aagtcgaaag gattttataa tattaagtca agttagtttg tttgatcaac aaactaatga 1604641 aatgaacttt cattatccac aagataagat cttactaata tggatggaag ggggataaga 1604701 gggtcgattt aatggagcta aacaatataa gaaacgaaag aatgaggctt ttatcctttt 1604761 ccaggtatat aaggtatgac gaaaaaagat gaattttttg cttgctgatc accatatttt 1604821 tttgcactgt tttgaaagcg cttttataaa agtttactga ccgtaaattc gagaaattgt 1604881 tataccgttt cacactgttc catattaaag gatcgaaaag gggagaaatc atgctcagtg 1604941 aaaatgtaaa gaagattagc atggttgaaa aagttggata tgcgtctgga gattttgctt 1605001 gtaatttaat ttatgcaaca gtgtctacgt atcttttgtt cttctataca gatgtttttg 1605061 gtttatcggc agcagcagcc ggtactatgt ttttagtggt tagaataatc gacgctctcg 1605121 ctgatccttt tatcggaaca atagttgaca gaacgaacag cagatttgga cgctttagac 1605181 cgtatctttt attcggagct tttccatttg tcatactggc aatactctgt tttacaacac 1605241 cagacttttc ggatatgggg aaattaatat atgcctatat aacctatgtt ggcttgtcgc 1605301 ttacatacac aacgataaac gttccatatg gcgcgttaac ttctgcaatg actagaaata 1605361 atcaagaagt tgttagtata acttctgttc gcatgttatt tgcgaatctt gggggacttg 1605421 tcgttgcatt ttttgttccc ttactggctg cttatttaag cgatacttcc ggcaacgagt 1605481 ctcttggctg gcaactaacc atgggtattt tgggaatgat aggcgggtgc cttttaatct 1605541 tttgttttaa aagcacaaaa gagcgggtca ctcttcaaaa atccgaagag aaaattaaat 1605601 ttacggatat atttgagcag tttcgtgtta atcgtccact tgttgtatta agtattttct 1605661 ttattattat ttttggagtg aattccatca gtaattcggt tggcatttac tacgtaacgt 1605721 ataacttaga aagagaggat ttggtgaagt ggtacggttt gataggaagt ttacccgctt 1605781 tggtcatttt accgtttatt ccaaggcttc atcaattttt ggggaaaaag aaattactaa 1605841 actatgcatt attactgaat attataggcc tcttagcttt actgtttgtt ccgccaagta 1605901 atgtttacct catacttgtc tgtcgattaa tcgctgctgc tggaagtctc actgccgggg 1605961 gatatatgtg ggcgcttatt cctgaaacaa ttgaatatgg agagtacagg actgggaaaa 1606021 gaatgggtgg gctcatttac gctataatcg gatttttctt taagtttggt atggccttag 1606081 gaggagttgt tccgggtctg gttcttgata agtttggata tgtagcaaat caggcacaaa 1606141 ccccggcggc cttaatgggg attttaatta caacaaccat tattcccgtg ttcttgcttg 1606201 ttctagcttt aattgatatt aatttctata acttagatga gaaaaaatat aaaaacatgg 1606261 ttcgagaatt agagaataga gacaaagttt atttggatca tattgatgat ttcaaggctt 1606321 aaaaaagaaa ataaactgag gaggagtccc aaatgaagat taccaatccc gtacttaaag 1606381 gattcaatcc cgatccaagt atttgtagag caggagagga ttattatatc gctgtatcta 1606441 catttgagtg gtttccggga gtccagatac accactcaaa agatttagta aattggcact 1606501 tagttgcaca tccattacag agagtttcac aattagacat gaaaggaaac ccaaattcag 1606561 gtggagtttg ggcaccatgt ttaagctata gtgatgggaa gttttggctg atctatacgg 1606621 atgttaaggt agtagatggc gcatggaaag attgtcacaa ttatttagtt acttgtgaaa 1606681 cgattaatgg tgattggagt gagccgatta aattaaatag ctcggggttt gatgcttctt 1606741 tgttccatga tacggatgga aaaaagtatt tattaaatat gttatgggat caccgtattg 1606801 atcggcactc atttggagga attgttatac aggaatattc tgataaagag caaaaattaa 1606861 tcggtaaacc aaaagttata tttgaaggaa ctgatagaaa actgacagaa gctccgcatc 1606921 tttatcatat cgggaactat tattatttat taactgcaga aggaggaaca cggtacgaac 1606981 atgctgctac aattgctcgt tctgcaaata ttgaggggcc atatgaagtt catcccgata 1607041 atccaatttt aacgtcatgg catgacccag gaaatccatt gcaaaaatgt ggtcatgcat 1607101 ccattgttca aacacataca gatgagtggt atttagctca tttaacggga cgtcctattc 1607161 atcctgacga tgattcaatt tttcagcaga gaggatactg tcctttgggc agagaaacag 1607221 ctattcaaaa actttactgg aaagatgaat ggccctatgt agtaggtgga aaagaaggaa 1607281 gcttggaggt agatgcacct tctatacccg aaacaatatt tgaagcaacg tacccggaag 1607341 ttgatgaatt tgaggattca acattaaata taaattttca aactttaagg attccattca 1607401 cgaatgaatt aggttcattg actcaagcgc caaatcattt acgattattc ggtcatgaat 1607461 cattgacctc gacatttact caggcatttg tagccagacg ctggcaaagt ctccattttg 1607521 aagccgaaac tgctgttgag ttttatccgg aaaattttca acaagccgct gggttggtga 1607581 attactacaa tacagagaac tggacggctc ttcaagtcac gcatgatgaa gaacttgggc 1607641 gcattcttga attaacaata tgtgacaact tttctttttc acagccatta aataataaaa 1607701 ttgttattcc tcgtgaagta aagtatgtat atttaagagt aaatattgaa aaggacaaat 1607761 attattattt ctattctttt aacaaagaag attggcacaa aattgacatt gcactggaat 1607821 cgaaaaaatt atcagatgat tatatccgtg ggggaggatt cttcacaggg gcctttgtag 1607881 ggatgcaatg ccaagatacc agtggtaatc atattccggc cgactttaga tattttcgtt 1607941 ataaagaaaa ataatttgca catgaaaaag gagatttcta ttttagaact cctttttcat 1608001 atgagaaggt gccatgtcac tattgcttca gaaatactcc tagaataaaa aaactcatct 1608061 ttaaagatga gctgtccatt ccataaaaaa ttacattgta atcatgtcca gaaaatgatc 1608121 aatcacaatg gaggacattc ctaatgccgg tgcattctgt cctaaggaag atggcaataa 1608181 ttcatagcta ttgcctaatt gggaataaac ccttgatgat acttcacttc tcattgaatt 1608241 taaaaccata ggatgcgatt caattatgct atttcttaaa attacggctt gtgggttgaa 1608301 agtatttaga atattggtaa ggcctattcc taaatagaat ccaaaatttt gtaatgcatt 1608361 taaggttccg atatcattca gatgggcgag gtttatgata tcttgatagg acagtttttt 1608421 ctctttggtc tgaagagatt ttaataaagc cttctctgaa gcatacaatt cccagcatcc 1608481 tcggtttccg caactgcatt taggaccatt aaagtctatt gtcatatgtc ccatttctcc 1608541 agagaagccg cttactcctc tatataaatg attgttgata ataacaccga tccctattcc 1608601 tgtgctgata cttacgtaaa taatgttatc gtgatttttt gcagctccaa atactttttc 1608661 tccatatgcg ccagcatttg cctcattttc aataaaaaca ggcacattgt acttctcttg 1608721 tatcgaagat tttaagtcaa tatctctcca gttggagttc ggagtgaaaa caattttttg 1608781 atctttatca atgagtccag gcacgcaaat acctatacca ataagcccgt acggagattg 1608841 gggcatttgc gtaataaagt gatgaatcat atcaatcaaa atgtctttcg ttatttctgg 1608901 agaattggat tccaaatggc ggtattgatc aagaacgatt gttccttcaa ggtctgttaa 1608961 aatgccatta atataatcca caccaacatc tattccaacg gagtatcctg cctttttatt 1609021 aaaaacaagc atgacaggtc ttcttccgcc acttgattgt ccttgaccta tttcaaatac 1609081 catactttct ttcattaacg tgtttacctg tgatgagaca gttgatttat ttaatccagt 1609141 catttcagat aattttgctc ttgaaatagg tgaattttta aggatttctt ttaataataa 1609201 cttttgattt acttttttga caaaggtttg atcagcgata tccacttcat ccactccatt 1609261 tgtttaatct ttaaattaag tatcaacata gtacatagcg aatcttccct ttattatatc 1609321 taatgtgttc ataaaaaact aaaaaaaata ttgaaaatac tgacgaggtt atataagatg 1609381 aaaataagtt agtttgttta aacaacaaac taataggtga tgtacttact atatgaaata 1609441 aaatgcatct gtatttgaat gaatttattt ttaaggggga aatcacatgg ctcaatctca 1609501 ttccagttca atcaactatt ttggaagcgc aaacaaagtg gtttacgaag ggaaagattc 1609561 gactaatcct ttagcattta aatattataa tcctcaagaa gtaatcggcg gaaaaacgct 1609621 gaaagagcat ttgcgatttt ctattgccta ttggcataca tttactgctg atggtacaga 1609681 cgtttttgga gcagctacga tgcaaagacc atgggatcac tataaaggca tggatctagc 1609741 gaagatgaga gtagaagcag catttgagat gtttgaaaaa ctagatgcac cattctttgc 1609801 ttttcatgac cgggatattg caccagaagg cagtacgcta aaagagacaa accaaaattt 1609861 agatatgatc atgggcatga ttaaagatta catgagaaat agcggcgtta agctattatg 1609921 gaatacagca aacatgttta cgaatccccg tttcgtccat ggtgccgcga cttcttgcaa 1609981 tgcagatgtg tttgcgtatg ctgcagcaca agtgaaaaaa gggttagaaa cagcaaaaga 1610041 gcttggcgct gagaactatg tattttgggg cggccgtgaa ggatatgaaa cattgttaaa 1610101 taccgattta aaatttgagc ttgataattt ggctagattt atgcatatgg cagtggatta 1610161 tgcgaaggaa atcgggtaca cagggcagtt tttgattgag ccaaaaccaa aagagccgac 1610221 cacccatcaa tacgatacag atgcagcaac aaccattgcc tttttgaagc aatatggctt 1610281 agacaatcat tttaaattaa atcttgaagc caatcatgcc acattagccg ggcatacatt 1610341 cgaacatgaa ttacgcatgg caagagtaca tggtctgctt ggctctgttg acgcaaacca 1610401 gggtcatcct cttttaggct gggacacgga tgaatttccg acggatttat attctacgac 1610461 attagcaatg tacgaaatcc tgcaaaatgg cggccttgga agcggcggat taaactttga 1610521 cgcgaaggtc agaagatctt ctttcgagcc tgatgatcta atatatgccc atattgcagg 1610581 gatggatgca tttgcaagag gattgaaagt tgcccacaaa ttaatcgaag atcgtgtgtt 1610641 tgaagatgtg attcaacatc gttaccgcag ctttactgaa gggattggtc ttgaaattat 1610701 agaaggaaga gctaatttcc acacacttga gcaatatgcg ctaaatcata aatcaattaa 1610761 aaacgaatct ggaagacagg agaaattaaa agcgatattg aaccaataca ttttagaagt 1610821 ataacaggat aagctccaga tcctgctatc aataccaagt cactgaatta cccgtcatga 1610881 ttcctttcct attgcttgtt gttatgacgg gtaacttcta taattaggat ttatttagag 1610941 tgaatggttt tttaaaaggg caaggagtga aaaaatgaag tatgtcattg gaatagatct 1611001 tggaacgagt gctgttaaaa ccattttagt taaccaaaac ggcaaggttt gtgcagaaac 1611061 gtccaaaagg tatccgctca tccaagagaa ggcgggatat agtgagcaaa atcctgaaga 1611121 ctgggttcag caaacaattg aagcattggc tgaattggtt tctatatcca atgttcaagc 1611181 caaggatatt gacgggataa gctattcggg acaaatgcat ggattagtac tgcttgacca 1611241 agatcgtcag gtgttacgta atgcaattct ttggaatgat accagaacaa cgcctcaatg 1611301 tataaggatg accgagaaat ttggcgatca tcttcttgac atcacaaaaa accgtgtttt 1611361 agaagggttt acattaccta aaatgttatg ggtaaaggaa catgaacctg aactttttaa 1611421 aaaaactgct gtgtttttgc ttccgaaaga ctacgtgcga ttccgtatga ccggtgtcat 1611481 tcacaccgaa tactccgatg cagcaggaac tttactttta catattactc gcaaggagtg 1611541 gagcaatgat atttgcaatc aaattggtat ttctgcagat atttgtcctc cgcttgttga 1611601 atctcatgat tgtgtaggat cgctgcttcc gcacgttgcc gcgaagaccg ggctattaga 1611661 aaaaacaaaa gtgtacgctg ggggagcaga taatgcttgc ggcgctattg gagcaggtat 1611721 cctttcttcc ggaaaaacat tatgcagtat tgggacgtca ggggtcatac tttcctacga 1611781 agaagaaaaa gaaagagact ttaaagggaa agtccacttt tttaatcatg gaaaaaagga 1611841 ttctttttat acgatgggcg tcacgctcgc tgcaggatac agcttggact ggtttaaaag 1611901 aacgtttgca ccaaacgaat cgtttgagca attattgcag ggggtggaag ctattccgat 1611961 aggagccaat ggactgctat acactcctta tttggttggt gaaagaacgc cgcatgctga 1612021 ttcttctatt cggggaagct tgatcggaat ggatggagcc cataatagaa agcatttttt 1612081 gagggcaata atggaaggta tcacattctc tttacatgaa tcaattgagc tattccgcga 1612141 agcgggaaaa tcagttcata ctgttgtttc tattggtggg ggagctaaaa atgatacgtg 1612201 gctgcaaatg caagctgata ttttcaatac gagggtaatt aagttagaaa atgaacaagg 1612261 gccagctatg ggggctgcaa tgctggctgc ctttggaagc ggttggtttg aatcacttga 1612321 agaatgtgca gagcagttca ttcgtgaggc tgctgcattt tatccaaagg cgcaaaatgt 1612381 tcaaaaatat aaaacactat ttgatttgta taagaacatt tacactcaca caaaggatct 1612441 caatacagct ttgaagagct ttcgaaaaaa ctaatgatgt tattgtctgg agatcaaccg 1612501 aagaacaatt aatgatcaat catcatcaaa ggcctttgat aacatggctg ccttcttttg 1612561 aaaagatggt gagaataagg tatcgcaacc tttaaacagt attggagtat ccagcagaca 1612621 aaacgaacga gtggaaccgt attttgtcag cgaacacttc aagaagtggg gaagcttagg 1612681 aatgccaatg ggtaagatgt atgaaaccgc gctaacgacg gtagagggat ctcttgattt 1612741 atgaagaaat aggaaggatg ttaacacaca aataacccct cacattgacg tgaaggggtg 1612801 ttttttattg ttactataca gcggaaattt tacaggctag ttgcatgatt ttagcttgtt 1612861 aagcagaatg gaactagact ctccatcatc tctttctcat tctttggaaa ctgcattctg 1612921 ctaggtttgc tgcttttttt aacaaacagt gtttttctat ttcacacagc cattaaatcc 1612981 tctgttcgtc acataaccgc tcttactcca aattgacagt ttatctgatt ttgcttcttg 1613041 ctcatctagt ctgaattggt ctatgtattt tgtgttaggc tcatatacat atgctactct 1613101 ggccaatccc tctttcaata atgtctcttg aacagatttg ccgtcaacat aaacgtatgc 1613161 taacagtctt ccatacttat ctctgcgatc gcctttatca aattccagct gtagcttacc 1613221 gctgttgacc aattctttat ttcgtttcga cgcatcctca ccgtatggtt gaacacaaga 1613281 atttggtttc ttcgtctcag gtgtatcaac gagcaagtag cgaactgtgt ctttctttcc 1613341 gttgtaaata accttaatcg tatctccatc tattgctcta tctaatgtaa cattgaccaa 1613401 tttcttctga ttttttgaat gaggcgtgcc agccttttgt tctgtctgat tatattcatt 1613461 agagtgagta tcttgagaga cttgctccgt cccattagaa tctgaatggt ttttggctgc 1613521 gtgatttgat ccgcaagctg ccaaagtaat acttaaaacg attgcgatca tactgatcaa 1613581 aatcttcttc atattgattc cctctttatc attttctctt ttcgcgatta aacatcatca 1613641 ttataacgat atggacattt tttgtgaatg gaaaacttca agggaactta taacactcca 1613701 aattgccaat agttaacttc acaacgagat gatcaaaaca tcaccatcac atagcggaaa 1613761 taaataatcc tgaaaataat attgactgaa aatgctttta gaattatgat aatatgagaa 1613821 atgacaataa tgtgacaaag acattactac aacataacaa ctaatagctt aggtttattc 1613881 tattggttaa aaatgtaaac ggttacaaat ccagaggcga aaatctaaga tagagatgac 1613941 tttagttttg actcaatatc cacactgaaa gagcttatta agtattctta aaggcagggg 1614001 aaatggatat gaatgaacat cgaaatcgaa ggttgaaatt aataatgatt tcagcaactt 1614061 ttggagggct tctctttgga tatgacaccg gagttataaa tggagcttta ccttttatgg 1614121 caaggccaga tcagcttgat ttaacacctg ttacagaagg gcttgttacg agtattcttt 1614181 tattaggtgc cgcgtttgga gcgttgttat gcggaagatt ggctgatcga tatggccgcc 1614241 gtaaaatgat ccttaatctt tcctttttat ttttcctggc atcactggga acagcgttag 1614301 cacctaatgt tttcatcatg gcggtctttc gttttttact ggggctggct gttggaggag 1614361 cctcggcgat ggtgccggcc tttttagcag aaatggcacc gcatgaaaag agagggcgta 1614421 tggtaaccca aaatgaacta atgattgttg gcgggcaatt tttagcatat gtttttaatg 1614481 cgatcctcgg tgtaacaatg gcaaatacgg gacatgtttg gagatacatg ctagtcattt 1614541 gtgctgtacc ggctatcatg ttatttgcca gtatgcttaa ggtaccagaa agcccccgat 1614601 ggctaatctc caaaggcaaa aacagtgagg cgctgcgagt tcttaaacaa attcgagaag 1614661 ataaacgtgc agaagctgaa tgtagagaaa ttcaagaagc ggtagaaaaa gatacagcac 1614721 tagaaaaggc atcactcaag gacttttcta caccatggct gcgccgtctt ttatggattg 1614781 gaatcggtgt tgccatcgtg aatcaaatta caggtgtgaa ctcgattatg tattatggca 1614841 cacaaatcct taaagaatct ggttttggta caaaagcggc tttaatcgct aatattggaa 1614901 atgggctgat atcagttatt gcagttatat ttgggatttg gctggtcgga aaagtgagac 1614961 ggcgtccaat attattgatt ggtttggcag ggacgactac agcgctccta ttgattgcga 1615021 ttttctcaat tgtgcttgat ggatctatgg cacttcctta tgtagtgctt tctttgaccg 1615081 ttttatttct tgcctttatg caagggtgtg taggacctgt gacttggctt gtcatagcgg 1615141 aaatattccc tcaaaggtta agaggacttg gttctgggat aagtgttttt ttcctttgga 1615201 tattaaactt tgtgatcggt tttgctttcc cgatcttgct tagctctgta ggtttgtctt 1615261 ttacattctt tatatttgtg gctttaggtg tattggcaat cggttttgtg tacaaattca 1615321 tgccggaaac aaaagggcgt acacttgaag aattagaaga gcattttcgt tctcgacacg 1615381 atcataatac tcctgaacaa tcagttattg aggtataaat atgttgaaaa tctctcttct 1615441 tataggaggg atttttttag tttcagaaaa aacaaaatcc ctctggtaga gggattttga 1615501 ttcagcattt taagatgttc tacacgtata atactggagt tgatacttta aaaatctcgc 1615561 catctcttat ataaaaacga gggatgcggc ggcttaatgt agacacgact tcatagttaa 1615621 tcgtattgag catttcagcc acttcatcaa cggaaatctc ggctcctttt tgcttaccgt 1615681 aaatcacgac ttcatctcct tgtttacctt caccgttttc tcctaaactg accatgatca 1615741 tatccattgt tactcttccc gccactggca ctcgttttcc gcgatgaaga acaaacccgc 1615801 gattggaaag ggcacgagaa tagccgtcag catagccaat cgggagtgta gcaattactt 1615861 cattaggttc tgcgatgtat gtagcaccat agctaacggt tcggggttct gtccgcatgg 1615921 ttttcacata agcgatgcgt gcctttaaac ttaacgcagg ttcaagctta acgagattta 1615981 gttgtttaat ataggctgaa ggatataaac catataagcc gatacctaaa cggatcatat 1616041 cagcgctaaa ttccggaaat gcgatagctg cagccgtgtt gcacatatgc acggtgggca 1616101 gctcaatccc ctgttttttt aaaaagctga gaaaactgat gaatttttca tgctgcagct 1616161 ttgtgagtgt tgtgtccggt tcatcagctg tcgaaaaatg tgtgaaaatc cctgtccatc 1616221 tgaggaattt acttgccttt aaggctttca ctacctctaa aagttcttcc tttgtgcgta 1616281 cacctaatcg tcccatgccg gtatccacgt taatatgaat ggccagccgg ttagcactcg 1616341 cttctttttc caatatctcg tttgcttctt tcatccaatc aacctgaaat gctgataatg 1616401 ttatattcca agctgctgac ttctttacac aactaaggga tgtaaaacca agcacaagga 1616461 taggtgctgt aatcccagct ttacgtaaaa cgattccttc ctccacactg gcaacagcga 1616521 gctcactcgc cccgtgttcc agtgcatggc gtgccacttc tatagacccg tggccataac 1616581 cgttcgcttt tacaacagcc ataattttgc tcttatgtgg aatatgacgg cggatcgctc 1616641 gcaaattctt tttaacggca tcaagattga cttcgatcca aacttctcgg caaagcttta 1616701 tcatcaacgc ttccttcctt cttatggatt ataaatacca cctattgccg caagaataaa 1616761 tgttaattgt tggatgattc gatcttattt tattcaactt tatttgaaat cattcaacag 1616821 caaatccatg tgatacgaga aggtgcctat caatgttcga ataatagcaa gtacgggata 1616881 catgaggctt gtaagtgggg tgttaatgga tgcggcgacc gaggattaca aaaatgatta 1616941 tttgttttgg gacatttttt tctaagggta gatgataacg agaaatctaa tcaggaaata 1617001 cttaccgttg ttatgaacat tgaagaacct tttaaatgag aagggctgag gaaattctgt 1617061 aaaagataat cggttgaaaa ggcagtcgat tccttgttcc ataaacctaa catcagagta 1617121 tataattata ctcgtattca caaaaatcgt ttaagtaagg ggtatacatg aataggggag 1617181 ttagttttca aataccgaat gaatatggaa attttctatg gagaatactg cagccggtag 1617241 aaatagctaa ttataggtgg caaacgagtg gggaatctta ttttgttgta gaaggagagc 1617301 tcgatgatga ggagcttttt catgactacg aaattgttga gggggcagtt tttgagcaac 1617361 aattaaaaac gaatcagtac tataccattt tcgttgaact gaaagcattt ccatatggaa 1617421 aaatggttaa tcaagtcaat acatatgaag agtttgctga cagtgattgc gaacttgtcc 1617481 ttttgatagc agataatagc tacgtttcga tttactgtaa aaacaaaaat atcattgaaa 1617541 aactttactt caatgcttta cagcatgatt ttgaagacgt tcaatttata actgatgaaa 1617601 atgacacaag aacaagcctt actgtatgat actcaataaa aattaaagga gctagtacat 1617661 gacaatgcaa attaaaatca agtatctaga tgaaacacaa acaagaatca gcaaaattga 1617721 gcagggagac tggattgatc ttcgggcagc tgaagatgta acaatcaaaa aagatgaatt 1617781 taagcttgtc ccattaggtg ttgcaatgga gctgcctgaa ggttacgaag cacatgtcgt 1617841 ccctcgttca agtacatata agaactttgg cgttattcaa acaaattcaa tgggtgttat 1617901 cgatgagtca tataagggag acaacgattt ctggttcttt cctgcttatg cattgcgtga 1617961 tactgaaatt aagaagggtg atcgtatctg ccagtttaga atcatgaaga aaatgccggc 1618021 ggttgaattg gttgaagtcg agcatttggg aaacgaggat agaggaggac tcggttcaac 1618081 aggtacgaag taaacaaaat aaatccttgg ctgtcttcat gctgtgtgat tgatcaatgg 1618141 aggtttcagc caaggtacat ataaatatta tgtataaaat gaatatttta atacgaagga 1618201 tttaattaaa aacaaagttt aaaaagggaa gttttgaaaa agtgaaatag taataactaa 1618261 agtcgataaa gaacctaaag atgtcaaaga aacaattttt ctggtgcttt gcttttttga 1618321 aggtttactt agctcgtgga taactgcccc ccataaaagc atggatgcta aaattataat 1618381 acttatatac ataaagatgc tccttttatt atatttacag tttttacatt tttatcgatt 1618441 ttaccacatt taggattgag ttgtcgatga aacaagcatc tctataaaga aatactttta 1618501 tctaaatttt tataaatagg ggaaggcaac taaaaactag taatgccact aataataagc 1618561 caagttaaat gacttgtgtt cattaataat tgaattttac agcagccatg agcacaaaaa 1618621 aatctgagtt cgtcgataaa tatcataaaa aagcccccgg tatgtcgcca gggaataaat 1618681 agacgtttaa gagatttagt gatgtttttt atatgattcg acaaaatcat aataatgatc 1618741 atcgtcatca taatactttt tttcgtaatg ataatcgtga tcatcgtaat actttttatc 1618801 atggtcatca tactttttgt cgtaatcata atgtttttta tcatgatcat aatacttgtc 1618861 gcaatcataa tgcttcttat cattgtcgta atactttttg taatatgttt ttttccaagt 1618921 ataatactct tctttatatt ttttataata acccaattaa attcctcctt tatgttattc 1618981 gaatttaatt tatgaagttt aaatgatatg gtatggtcaa atgaaataag aatagtaaaa 1619041 agaggctgtt taaaacactt tctgaaaaac aaaacggata gctgtttatg aaaataagag 1619101 cgagagagag cactcaatca ctgtaaaata atagtaaagt gtatagagag attagtatac 1619161 gtaaaaaggg actttctcat tgaagaatat ttgaacgtta tggttaagat tcaagagctc 1619221 tatgatgtga tttttcacac tgcttttgaa ggatttagag ttagacatca aaaacaaaca 1619281 gcaaaaccgg ctagaaacag atcatataag gaatgaaccg ctgccaaata tcataaaaaa 1619341 gttgttaatg atcaaatgaa tgaaattaga gagaatttat tttaaagaaa gcccaattgc 1619401 acatggacaa atgacaattg atattgaggt aaaatacaat gcattaaatc agaaaaagct 1619461 attggaggat ttaatgtgtt tagacaattt ccaatttggt atacacaaac acctgactat 1619521 ttgaattttt atgtaccgca atatcaaacc atttcgtata atcctcaaca atgttatcaa 1619581 cggtgtatgt accaaactgg cggtaactat gagctatgtg acagactatg ttatggagaa 1619641 atacaggtgt aaaagagggg gattaactcc tctttaaaca cacagtgagt ggaataagat 1619701 cctcacttta tctgcaagtg cttagtattt gcgataatat tgcattcgta ataaattatg 1619761 cttagcaact gaaaatgaaa gaaggatatg aatagtcatg acgcaattcg ataaacaata 1619821 caattcaatt ataaaggata ttatcaataa tggaatctca gacgaagagt ttgatgtaag 1619881 aaccaagtgg gactcagatg gaacaccggc acatactcta agtgtaatca gtaagcaaat 1619941 gagattcgac aactcagagg ttccgatttt aacgacaaaa aaggttgcct ggaaaacagc 1620001 cattaaagag ttgctctgga tttggcagct gaaatctaat gatgttaatg atttaaacat 1620061 gatgggcgtc catatttggg atcagtggaa acaagaagac ggaaccatcg gacatgcata 1620121 tggatttcag ctggggaaga aaaacagaag tctaaatgga gaaaaagtgg atcaggtaga 1620181 ctatcttctt catcaattga agaacaatcc atcttcacgc agacacatta caatgctgtg 1620241 gaatcctgat gaattagacg caatggcctt aacgccatgt gtatacgaga cacaatggta 1620301 cgttaaacat gggaaactcc accttgaggt aagagcacgg agcaatgata tggcattggg 1620361 aaatccattc aatgtattcc agtataatgt gttgcagcgc atgattgctc aagtgactgg 1620421 ttatgagctt ggtgaatata tctttaacat tggggattgc catgtgtaca cacgtcatat 1620481 agacaatttg aaaattcaaa tggaaagaga acagtttgaa gcacctgaac tatggatcaa 1620541 tcctgaagtg aaagattttt atgactttac cattgatgat ttcaagttaa tcaactataa 1620601 acatggggac aagcttttat ttgaggtagc ggtttaatgc tgccttttta ttgtgcagtg 1620661 aatagatagc aggtatccta atttcattaa gcaatctgga agatgaataa aaattgaagg 1620721 acaaacacgt ataatacata aaaaagatta actctacagt taatcttttt tattcagaag 1620781 aaaatatcct aactttgaaa ctaaatacaa agtaaaagca atcattacag ttctagatat 1620841 tacaattcca tgaatagcta gatcatatcc agcaggtatc aacgcatttg tattacacat 1620901 aaaatatata gatattagaa gtgctacaat aactaaaatc attccaaaaa gacttgtttt 1620961 ttcatatttc ataccaattt ccacccttat taaagttagg tttaaacaaa agagctgaag 1621021 aaacgaacta tgaccagtat gctccaagga aaaccgccag acaatgctgg cggctttttg 1621081 ctgcttcgtt tatttattaa cagagatcgt aacgttattt cctgcaactg aaacctttgc 1621141 gaaatcctgt gtatctacca caggagtgac ggctttattg tcgatagtga tgttgttaaa 1621201 agaggtcgaa aaggttgctt tgatcgcatc acgctggctt tcatacgaaa cagccgcggt 1621261 agcaagtgtt ttccattttg aaatcgtgcc gatgttggtt ccttgaattt ctgtgataat 1621321 ccgtccggtg tagccgtcat tgttcgttcc ccaaagggtc atgcgcgtat tgccgcttaa 1621381 atttttatag attgtcattt ggactgtgct tccagggcgg aagcctttat tgtatgtgaa 1621441 tttgtctttt ccttcgatgt acgtttcttc atttttggac ccaaccttca tgaggggctt 1621501 ccagacgttg tattgtttgc tgtactgaag cccgatatcg gcttcagttc cgcttgttgc 1621561 cctaaagcca gaataaatat agggagtaga gaccgagtcg ttgtttttga cagtttcagg 1621621 aagcacgatt ttagctgtaa aaacggcgcc cgtactgttc aggtagacac ggccgccgat 1621681 tccgttaggc agctcggatg ctgcttttgc gacttgagcg tctgccgcgg gtaaacctgg 1621741 tatacctgat gaaagggttc cgaaaagaac tgctgttcct actgcacctg caatcaatac 1621801 ttttttcacc aaaattcccc cttttgatag tggtttcgcc atttattata ccttattttg 1621861 gaactggatt tacgtatata aatcgacaaa atatttcatt ttgaatgatg taaggtcgaa 1621921 acgcttcgcc aatctgaaag ctatatacct ttatcagagg aaagaatgag atcacattcg 1621981 ttttaaccga tttgaaattt tcctcaaaat aaaagtacaa atgcttaaag aaacgattat 1622041 taaaagaatg cccgctatcg tttccaagcc tgtaaaaaag aggtgacgtt tcatcaatgt 1622101 ctgtccttgt aaaatgataa aagcacagat accgactaag aaaagaaaac aaatacttag 1622161 gattgctaac gctttacgtg agtatgtttt catttcatct ttaaaataca gcaatacgaa 1622221 aataaagcag ataacattgg ctattgttct aatcacctca aagcttttca tgacaactga 1622281 tataaataga caaagtaaaa tgagataaaa tacgatgttt ctatacaaaa aacctctcct 1622341 tttatgtagg atcctcaaag agtttataaa agtttctttg taactgcaat aaattgaatg 1622401 cgctcactta tgaactaact aaactatgta ctaaatattc actattcttt ttcagattca 1622461 gtcaccaagg ttttcataga aagggaagct tcagaaatat acatatagtg cacaaacaaa 1622521 aaagacccgg caatagccgg gggaaagtaa aaacgaggag atgttaatgg cgtttagtag 1622581 tgttttttat gctttttata ctctacaaca taatcatagt cttttttatc gtgatcataa 1622641 tattttttat catagtcatc atattttttg tcgtaatcac agtcataatc ttttttatca 1622701 tattcgtaat acttcttata atacgttttt ttgaccgtat aatactcttc tttgtatttt 1622761 ttgtaataac ccatatatac tcctccttta tttttactac gctttattat acggcgagta 1622821 gattttgcgg cttggacagt taaaatcata gaaggaaaaa agggctgtcc aaatgataga 1622881 aaaagacaga tgacacaaaa acaaatcaaa ataaagagcc gatttttcat cggcccaaac 1622941 gatttatcct acatttgttt gtcttctttg ttttctgagt cattttttct gatatcctga 1623001 gtcagtccgc ttgttgcttg tttaaattct gataaggctt ttcctgctgc acggccaagc 1623061 gccggcagtt tatcaggccc aaatactaaa aaacccacaa acaaaataac gagtattttt 1623121 gtgaagctta attccatatc cttttccccc tgattgaagt acaacctttt aaacaaatta 1623181 taagagatag cagtacaaat gggaatgcat ttattttgaa cattttaaaa ccagcacaaa 1623241 gacggattca taaaacggct gctgctgaat ataatgtcca atgccacctg cctaagaagc 1623301 aggaggcagg ctggatcaat tatgtagctc tgccggaaat gatacaaacg tagcggctat 1623361 cattgacata gaggagtggt gtagctgatg agattcacta aggtagttgg atttttgtct 1623421 gttttagggt tggctgcggt ttttccatta acggcacaag cagaaaaagc cggaactgcg 1623481 ggggctggag agtgggataa gttggggact tacacatata cttactcaag tccgacggta 1623541 tactcgaccg gaggagattt tagagtgtgc ctttcaggaa gcactccttt ttctgtttca 1623601 ctgcacttat atgaggatga tcccggtgac aatcctgatg attatgtagg ggcaaactat 1623661 ttttcacccg gagaatgcca cacctttggc agtattggaa aatttgtaga tgggagcaat 1623721 aacaaggccg agttctttgt taccgattac tctggtaaat ctaaaactgt tacgttttat 1623781 gattgatgga ctcaaattgt gaagtataac ccttggaaaa aaacaaaaaa gagagatacc 1623841 tctctctttt ttattcttcg acagccttac gaagccgttc atttacaatg ccagtccagc 1623901 cgccatccat cttaccgcga acgacggagc ttttctcgtt tgctttgccg atcacttcat 1623961 tcggctcttt ccagccgctg tgaataaggg taaaccctgt cttttccccc aagtcttcta 1624021 attgaaaggt aacgacccat ccttctgtat cccattcaaa agaaagttca gttggagctt 1624081 gaacagccaa aactttacaa ggggacggcc caaacggcga ttgtaagtga aattcttgtc 1624141 cttctttgag ctgaaagtca ttgggcataa accacttggc aatgccttct gaagtagaga 1624201 ctgtctccca gactttctga atgggagcct ccagagtaat gctttttgta atatccggta 1624261 atgcattttc gttgttttga gccatttcgt ttacctcttg acatatgatg ttttttcaat 1624321 tcaatcatat aataactaat aagatcatgt ccatagcgtg cattatttat gctagagctg 1624381 ctgttgaaca gcgtgtcagt cgccagtctg atctgtgaat gggagaattc tgcatgcgcg 1624441 aaaaagagag agaggtgtat gttgtcattt cgttcattct tgtttgcagc cgcaactgtt 1624501 atgtttgaac tgggattcct gttcagccaa tttattttgc gatttttgtt ttaatagtaa 1624561 atgagccatt ttctaaaaca ggaggttttt tatgcttgga aaaatcaaag cagccattga 1624621 taatagtcca gggaagccgg ccagaatttt agttagtgaa aaagcgtttc agcaattaga 1624681 ggaagaaatg cgctttgttt acgtttccaa accgaaaacg ataatgggga ttcctgtgga 1624741 agtttcagat caggcagaaa gcttcaagct ggaattttag ttttcccaga ctgctaaaag 1624801 gctcattttg tgttaattat gcaaaatggt caggttgatt tctttaaaag catgatgaaa 1624861 tgttcatcat gcttttttat tgagaaaaaa gacgaacata aaaaataggt atacgggaaa 1624921 aataatccta ttagagagag gggaactgac agatggataa catgatatca acacttactg 1624981 actggaatgt gtggtttcaa gcgttagtag tatttctcgt tccatatgta atctataaag 1625041 tgtttacttg gattcatgta taagaaggtg caatgatgag gtggcggaac aatcagtaca 1625101 aaacacagaa gcagcataaa tcagattatt cgacagctga aaagcaggat caggatgtgt 1625161 taaccggtaa catcggatac gacttagaac atgtaaaaag aaaaatagga cataacgggg 1625221 acgttcattt ccgtgagctt gaaatcactc aattacatgt gaaagcggca ttgatctttg 1625281 ttgaaggact gtctgatcag gacttgatta ataaaggact atcagtgtta gtcatgaatc 1625341 aacctaatca ggtaagcgat gaaatttctc aatccggcaa aggtatttta acttcgaaac 1625401 agataaaaaa tcaaatcgta tcaatcggtg atgtcataga ttcagagaaa atcagtgata 1625461 tcgtgttgaa tgttttcatg ggttcgacag cgcttctcat cgatggaata ccgcaggcct 1625521 ttcttctggg aactgtaaaa aaacaaaatc gaagtatcga ggagccgctt tcagaagcgc 1625581 ttgtcagagg gccgcgcaca ggctttacag aagagttgag tacgaataca gctcttttga 1625641 gacagcaagg aaaaaatgat caattaacat tgcagagatt tgaagtagga acacgattaa 1625701 aaaaggattt aattatcgct tatatgaatg acattgcaga tccaaaagta gtcgaggaag 1625761 taagaaaaag agtgagaggg attgagatcg atcatttgcc ggagtcaggc tacgttgaac 1625821 agttaattga ggataattat ttgagcccgt tcccgcaagt acagagtaca gaacgtcctg 1625881 atcgcgtcat aagcggatta atggaaggaa gagtagctat tctgcttgac ggcactccgt 1625941 ttgctttgat tgttccagtc actttcagca tgatgcttca atcgcctgaa gattattatg 1626001 aacggtggtt cccgagctcg ctcatcagat tgctgaggtt catcgcagca atgataacgt 1626061 tattcgcacc cgctttatat atatcattta tttcttttca tcctgggtta attccgacca 1626121 agctggcgat ttcaatttcc gggacgcgcc aaggtgttcc gttcccatct ctgattgaag 1626181 ccttatttat ggaagtcgcg attgaaattt taagagaggc ggggcttcgt ttgccaaaac 1626241 caattggacc cgcaataggc atagttggcg gattaatcat cggggaagca gctgtgcagg 1626301 cggggattgt cagtccaatc atggtcattg ttgttgcgct cacagcaatt tcttcatttg 1626361 ccatcccgca ttatagcaca ggtatagcac ttcggatgct tcggtttggc gcgatgtttt 1626421 gtgcggcggt gtttggattg tttggagtca ttatgtatta tctgctgcta agcagccatg 1626481 tcgtaaagct aaagagcttt ggtgtgccat acgcaagtcc ggcagtgccc tatcacttaa 1626541 aagattggaa agactttgtt atcagaatgc ctcttttagt catgaagcgc cggcctaaaa 1626601 tgatgaatac agataataca aaacgggtga agtgatgaac tcgacaggat ggtgataaag 1626661 tctcatgttc agcccaacca gtaaaatcac aaccgctcag gcaacgatta tcatcattaa 1626721 ttatatgctt gctgccggag ttcttacgct ccctcggaca gtaacagaac aaacacaatc 1626781 tcctgatgga tggatttcag ttttattagg cggggtccta gcggtaatag ccgggatgat 1626841 tatagctaaa ttaagccagc agtatcctaa ggagaccttt tatgaatact cccgacatat 1626901 tgtaggaaaa tggctcgggc atctgatcag tattgttttt attacttatt ttctggcact 1626961 cggtgcattt gaagtcagag tcatgtccga aatcgtggat ttttttctcc tcgaagggac 1627021 accttcttgg gccatcatta tgacagttct ttggattggg ctttattcaa ttacacaagg 1627081 cctagatccg attgcacggc tttttgaaat gatttttccg attacggtca tcatcttttt 1627141 aacgatagcc ctcatgagtt taggcatatt tgagatcaac aatttgcgcc ctgtattagg 1627201 tgatggaatc atgccggttc ttagaggtgt aaagacaacg aacctttcat ttacatgttc 1627261 agaaattatg ttcattttag tagcatttat gaaaaagccg aaaaatgcgg tgaaagcagt 1627321 tgtgatcggg acaggcgttg tgaccagttt ttatatgatt acgatgatta tggtcatcgg 1627381 tgcactatca gttgagggag ttgtgacgag aacatggccg gggcttgacc tgatgagaag 1627441 ttttgaaata cctggtttaa tatttgaacg gtttgaatca tttctgcttg tgatttggat 1627501 tatgcagctt tttgccacgt ttattatcac tttttatgca gcttccctgg gagtctcaca 1627561 agtttttaaa aagaaacccc tttcatgtat gtttgggctg cttcctgtta tatatatcct 1627621 ctcttgcatg ccgaaaaatg aaaatgacgt ctttatattg ggcgatacgg tcagtcatat 1627681 cgctttgtat atatttggcg ctttgccgat tttgctgtta gtcatttcga aatggaggaa 1627741 aagaggtgaa aagtaaacta aaacgtcaat tgcctgctat ggtcatagta tgtctgctga 1627801 tgatttgcgt aacaggatgc tggagcagtc gggaaataga agatctgggt ctcacattcg 1627861 ctatcgcaat tgataaagga aaagaaacga acactgaaaa agagttaaaa gaagagggcg 1627921 ggagctatcc gaaaaaagac aacattacgc tgacctatca atttgttaat gaaaaagcgg 1627981 caggcgcggg cacaagcggg ggaggcggta gcggacaagg agcgcaaaaa gcgtacatta 1628041 atataagtga aacaggggat tcattacagc agatcggaag tgaggttgca ttaagacggg 1628101 accgagaagt gtttagcccg catttaaaag ttgttgtcat gagtgaagat gtgctgcaca 1628161 catttcctat cgacgaaatg ctggatcaat tttttcgtga taatgaaatc aggctgagct 1628221 gtcttgtttt atctgctaaa ggggaagcaa gagacgctct ccagctgaaa gagaacggag 1628281 aaattccggc atttcggctg attggattag gtgaaaatga acataaagtt tccagaattc 1628341 ttccccctat gacactcgcg aaactaattg gaaaactgca ttctggcagc agctttttac 1628401 tgcaaaatgt ggttgcggcg aatggagcgg tcaagtattc cggagcagct gtaatcaacg 1628461 gaaaatcgaa aaaaatgata ggcaccttaa atgaatatga aactgagggg attacatgga 1628521 ttagaggaga agggaaaggc ggagttgtca aaagtcatga taaaaagagc caacagacgt 1628581 tagcgtacga tatcaataaa atcaaaagca gaattcagcc aatcgtaaaa gggaaagata 1628641 tttcattcca tgtcgatatt gaatcagaag gcgatttggt tgaaaactgg aacacaaaag 1628701 aggcgttgga cacccagttt atagatcgtc tcgaaacgac tattgaaaac gaggtaaaga 1628761 aaatagttgg tcaggtatta aaaaaaattc agcatgatta taaagcagat gttgcgggtt 1628821 ttgatgaatc ttttagactt acatatcctc acttatggaa aagggtgaaa aataactggg 1628881 atgacacctt cagtaaagcc gacatcacat acagtgtgaa cgtcacaatt actcatttcg 1628941 gcacggttaa aactcagtaa tgaatcccaa ggaagagaag gaaacctctc ttctcttttt 1629001 tatgcattta ttaggataaa gatacttttt ttggagagat atacactttt caaatcgacc 1629061 aatatgctaa tataggaatt gcttgaaata gaagggagaa ggggctgtga ggcagaaacc 1629121 gatttatgta gaaatcgaaa tgaaatctga tctggataca ctctgggaat atacacaaaa 1629181 cccatcactg cataaggaat gggatctccg gttttcaaat attacgtatt tgaatagtca 1629241 gccatgcgaa aaacagaagt ttctttacga aacaagggta ggctttggat taaaggtgtc 1629301 aggtacagga gaaaccgtcg gtgttttcaa caaatgttca tctgaaaggt cttcttcact 1629361 ggcttttggc tctgatcatc cattatctct gattcggcat ggaagcggct actggaagta 1629421 tatacagaga gaaaatggga aaatgacgtt tttaacacag taccaataca aaacagccta 1629481 cggactgctg ggaagatgga ttgatcgttt attatttcgg ccgctgcttg gctgggcgac 1629541 tgcctggagc tttgatgcat taaggctttg ggtagagcaa aataaacatc cgaagcgctt 1629601 cattcgatct gctatcatct atgtgttcat gtgtctgttt ttcagcctgt tttggttcta 1629661 tcaaggcttt gcaggtgtta agacaagcat attgacagga acagcggaga taggcttagc 1629721 tattttgtgg ctgcttcctt taaaaagaaa atggatcatt catggtgtcc aggcttgtat 1629781 ttttgctggg tttgcttgtc taggttccga aatattcatg tgggttctat tgagtgtgtt 1629841 ttccgctgca agcggcgctc ttagcctgca gctccccagt gccaggcgca caaaacgaaa 1629901 gagaaagaag tgacattgtg agttcgattt atgaaaaatc aattattaac tatcatttgc 1629961 tgcatcccaa gctgcagaaa cggtaccaat tagacgggtc tcatacattc agcgggacgg 1630021 gaacgatgtc agaaataagc ggaggctctt ttctggttag aatgctgtta aagctgggtg 1630081 tttttttcag atgcttcttt tcagaaagag gcaaagacat tccatttaca atacaaaata 1630141 gaacttgtct tttgaaatcg caacatacag gaatagaatg gaatcgtaca tttttcttta 1630201 aaggcaaaaa acgtttcttt gatgcgttaa tgatatatga cgagaaagaa aatagaatac 1630261 ttgatttctt cggcaaacct catctgctgc tgtctgtttt gacgttcgag gcatctcttg 1630321 acggctctct tacgatcaca tcgggaaagc aatggctatt gatatgcgga aaaagaatcc 1630381 cgctgccgaa atggctgacc ggtacatccg aagtttgcga aacgtttgat gaaaaaaaga 1630441 attgtttcac cattgaagtg catgtgcaaa atacaattct tggcactctt ttcttttata 1630501 agggaacgtt tcaggaggaa gagagagaat catgaaacga aatggcatag tcagtgcgct 1630561 ttgttttatt ggatttcttg cagcagaagc accggatatt tcagtggcag aggcactcgt 1630621 tttgttatcc attctatttt tcgtgccggg aatttttcct tttgtttttc gtcaatctcc 1630681 ggttcgtgct gctcagttta tggaaaacgg gctaatccag tgctatcctg tagccgcatt 1630741 ctttgcggtg ctggctctag tgacggaggt tgggggtttc gcacttatct ggtggatgta 1630801 cacagttttt aatgcattgt atgcgatcct ccgcctttgg gaaacaaaga tacatagaat 1630861 cgaagagaca tcagttttgt tcggtcttat ttatttggcg ggaggaggat tttggttttt 1630921 tgcttatgct gcccatttgc agatcatgca atttggccct ctcatcattt tgctgactgc 1630981 tgtccacttt cactattctg cttttctgat cccgatcttc aacggtttac tcggcagaac 1631041 cattagaaaa catcggatgt tgtacagttg gataacatgg gtgattttgc tttcgcccct 1631101 tcttatcgca ctgggcatca catattcaaa aacacttgat gtcattgcgg ttagcattta 1631161 tatggcggcg atttatcttc atgcattttt ggtgttcacg gcagcttttc gcaccaagac 1631221 ggggacattt cttattcggc tttcttccgc tgttttaatg ataacgattg ctttctcgat 1631281 gatttattca tttggtgtct ttcggcaaga agttacattg accatcaatc agatgatttg 1631341 gattcacggt tttgtcaacg cgtttggtgt tatcttgccc gctctcatag ggtggagaat 1631401 agaggatgcg aaaccttttg atgcagacag tgtaaagaca ttcagccgta tctacggaaa 1631461 aagaaagatt ggagaagaat ttttagctaa cattcaagct gaaaataacg ctcggtacag 1631521 cggacttgtg gatgatatgg gcagcctgcg ttcaaaagat ttttcaccag aaaaactggc 1631581 gccgctcatt ctttcgtttt atgaacaaac catcgaatac aatattaaag caaaagtaac 1631641 atggagcacg tggtttcggc cgcttgcaat tatttacgaa tggttcagca gaagaatcgg 1631701 ccaaatacat ctttcgacga accctgactg gtataggatg tacagcaaga taaaaggtgt 1631761 tcattcgaaa aaagacggaa gggaaagagt acgtgcctgg attagaacaa atgaaaaaaa 1631821 cgaaaccatt tttaccgctc tttattcagt gtatcgttca aatggagagg ggtatatgaa 1631881 tatttcttta ccgcttccat tcagcagcat gacaggtatt ttaaaaccat atcatcatca 1631941 ggagaagctg gttttaacaa gcaggcggag aaaaagcaga gcgggggatg aggggattta 1632001 tctgcaaaca agagcgggaa cttgtccgct tcctttatct gaaacctttc tgatagaagc 1632061 tgtacatgac aacaaattaa ccgctgttca tcatatgtgg ctgtttggaa taaaatttct 1632121 aactgttcat tacagcatta cacatattaa ccagcctatt gaaagaacct aacacaaaga 1632181 agaagcttcg tctgccagtt gtaatgagat gaactgtttt aaaattctgc accgcatcaa 1632241 gacaggaaag gaagggttta tggtgtttta tatcagttta tttctgattc tttggctggc 1632301 tgctgggttt gcagtgggaa tgaaacaagt gtatgtcgat cagctgtttg ataaagctgt 1632361 gatcgaaaga ctggaaaaag aagcgaatga tcatggacat gctgaccgga tgatcaaaca 1632421 gcgcgtcctt tatattgcag cagtgacagt aagcgggttt atttctgttt attatgaaat 1632481 gaaaacaatc ccgcaaaggc gaaacataag aaaaattgaa aaaaacatca tgaaattaaa 1632541 tcaagcaaaa aaacgaagaa tgaagagaaa ataaaaagtg cacaggccaa agggcaggtg 1632601 catttttgtt ttgtatggaa aatgggggag gtggtgccag cttacttttc ataaattcaa 1632661 aaatgagaag aacagcgccc gggctaatgg tatataatat tgtgaattta acaaaaattt 1632721 aacaaggagg acgagagaat tcgtgctaaa gcctcaaaga gacctacatt ctgttgattt 1632781 ggacttagag gcggagtaga tgaaaccggc caaagtatcc ctgctccgcc gtttgctcca 1632841 ttccttgaag catgttgatt gtaacatagc caaacgtttt ccatcaacta ttaaaattgt 1632901 aaaattattg atgattttta tggtgtttac tccgatttct tcaatttatg ctgaagatgt 1632961 atatcagaat tttgaggaat taaaaaacaa tgaagatcct tctgattatg gcgttgttac 1633021 gaaagaaacc ggaagccctg ttcttgtttt agctattcac ggaggaggta ttgaaggcgg 1633081 gacaagtgaa gtagcgagag agctcagcaa agagtactcg atgtatttat ttgaaggctt 1633141 aaaatcggca ggaaactcag tcctgcacat tacgagcaca cactttgatg aacctcgggc 1633201 ccttaaaatg acgggaaatc atgaatatgt catttcatta cacgggtacg cagaagaaga 1633261 tcagcagatc gaagtcggcg gtacagatcg cgtaagagcg gcagatttag ttgagaaatt 1633321 gcagcatgcc ggttttcctg ctgtattgct caatatggac catccgcatg cgggcgttag 1633381 tccgaataac attgcaaata aatcaaaaac aggtttaagt attcagatag aaatgagcac 1633441 agggtttcga aagtctttgt tcggcatctt ttctttaaaa agcagagctg ttactcaaaa 1633501 tgagaggttt tatgagttta cagaagtgat gttccgtttt ctcaaaaata gctactgaaa 1633561 aataggaggc gataagacag cctcctattc cttatgcttc tctttcgttt cgggaaacag 1633621 ctcgtccgcg gcttccgttt gatactgcaa cgtgttatct ctcgctgaca gttcatttcg 1633681 gaaattttca tcaagcacat ttttcagtaa ataccgatga aaaaagtatt caaaaacagt 1633741 aagacaggca gcggaaagga gagccgctcc aaatggtgag aaatcgtttc ttgtttgggt 1633801 taaaacaaat acccaaagaa taacgaatga aaggccaaag tcagccaatg aagctgtaat 1633861 attgtttgtt ctgggtaaga cgagcatgtc accagaaaga taggaaacaa aacctaagaa 1633921 aagtgcaata aacatcacac ttaaaaagga tgcgtgatag actctgtcca aaatcacata 1633981 taaaagggcg agagtgaaag caatctttga agcaagcgca atgatatgtt tcatttgacc 1634041 acctaaattg ttattttttg aagaaaattc ttgggcgtaa acaaatgata aataatgcaa 1634101 ttcaaaacca ttcataatgg tcatgttact attttaaaca gtccgttttt gtttacactg 1634161 gtattttttt cagctgtatg aaactttctt atgaaaaaag tcgtatatgt ggatgatcag 1634221 ctttcaaggg gggaatgatt tgtggagata aaaggaatca atcacttgct attttcagtt 1634281 tcgcatttgg atacatcgat tgatttttat caaaaagtgt ttggtgcaaa gcttttggta 1634341 aagggaagaa caactgcata ttttgatatg aacggcatct ggctagcgct taatgaagaa 1634401 ccagacatcc cgagaaatga cattaagctt tcttataccc atattgcttt tacaattgaa 1634461 gatcatgaat ttgaggagat gtcagctaaa ttaaaaagac ttcatgtcaa tattctgcct 1634521 ggcagagaac gagatgaacg cgatcgaaaa tcaatttatt ttaccgaccc tgacggccac 1634581 aaatttgaat ttcataccgg aacccttcaa gacaggcttc gatattacaa acaagaaaaa 1634641 acgcatatgc acttttatga tgaaacggcc ttttgatagc acaaccatat ttcatataag 1634701 gttaaattta aagaagggtg ttggtggaga ctttatgttt ggggaaggtt tctacccgac 1634761 ttgttcaacg atgccatatc ttttgaactg cacaagtgat tgggtgaagg tgaaattgaa 1634821 atacacatta cattacattt tatatgaaga aagcgagctg ttttatcaaa tgttgaacta 1634881 attaaactat gtactaaatt ttcagtatat ttcaattgct ttgcccctta ataaatataa 1634941 aaccgcatcc ttccacgacc taaaaaatga aacgttttta agaagatggc gtctaatatt 1635001 ctaaatgttc atattttgat aaaagtttcc taaaggaaag aaaatttctt gacttcaaca 1635061 atcttttggt ggataattat ggtgtaaaca tgatgttctt tttcctccta ttcgggctcg 1635121 cacccaaaag tcagggcgag cctgcttttt ttgaacaaca aaccccctct ccgtaaagga 1635181 agagggggtt attttatgca tctgatagat caatagatta atggacggtt ctgaacacgc 1635241 caatcacttt ccctagaatg ctgacattct gcaaaatgat aggttccatc gttgggttct 1635301 caggctgcaa gcgaatgtgg gtatcctctt tatagaatcg ttttacagtt gcttcatcat 1635361 cttctgtcat cgcaactaca atttccccat tgttcgctgt gttttgctgt ttaacgatga 1635421 catagtcctt atcgagaata ccagcatcta tcatactgtc tcccataatc tccagcataa 1635481 atacatgctc gtctggagga accatgcggt cagggagcgg aaaatattct tcaatatttt 1635541 ctactgctgt aataggagat cccgccgtga ctttcccgat gaccggtaca ttaacgacct 1635601 ggctttgcgg aatgtctact tcttcatcaa gaatttctat tgctcttggt tttgtcggat 1635661 ctcgtctgat cagccctttt gtttccaaac gggccaaatg gccgtggaca gtagaactgg 1635721 acgcaagccc gacagcctct ccgatctctc tcacggaagg cggatatcct tttgatttaa 1635781 cctctgcttt aataaaacgg aggatatcaa gttgcctttt tgatagcttc gtcatttttc 1635841 gcacctcaaa acgtcgattt taagaagatt atagcatgat tttccttaca gtacaaacat 1635901 aggttcgaaa aaacaattga cagaaacgtt tgttcgtata tactgaaatt ataaaaatgc 1635961 gaacaaacat tcctgttgga ggttatgatc atgagtaaag aatctattat ttttgtcggt 1636021 ctgtttacag tgattttgag cgcggttatc cttatgctgt catatacaag cagcggccaa 1636081 gagcttaatc agtatgttaa aatagaagtc cagcaaggcg acacactctg gtcaattgct 1636141 gatcaggtag ccgatacaaa aaagataaac aaaaatgatt ttattgaatg ggtagctgat 1636201 aaaaatcaac ttcaaacctc tgatatccag ccgggtgatg agttagtgat cccattgaaa 1636261 aagaagcatc aggatgcata tgaattagca actgtaagat agagaggaaa gagagataaa 1636321 atgaaagcac tcatttatgc ccgtgtaagc acaaataaag aacagcagga aacgtcatta 1636381 aagcggcagg aggaggagct tacggccatt gcagcggaga acggcatgga agtggtcaaa 1636441 gtgatttcag aaaaagccag cggatatgaa atggatcggg atggtgtatt tgagctgctc 1636501 gatgagatta agaacgctga tattgatgtc attttggttc aggatgagac aaggctcgga 1636561 cggggaaacg caaaaatcgc actgcttcat tgtatttata gagaaggtgt gaaagtctat 1636621 acaacggctc atagaggtga actggagtta tcggaggctg actcaatggt cttggaaatc 1636681 gtcagcattg tggaagagta tcagcgaaag attcacaaca tgaaaatcag acggggaatg 1636741 aaacgtgcag taaaaaacgg ttttaaaccg caaaaaaact taaaaaacca acatgggaac 1636801 agtggaaaag aaaaaataga ggtgccaatc tcagagatcg tccgcctgag agcgaataaa 1636861 ctgacgtttg ctgaaatcgc ggctacccta agagggtttg gctatgatgt ctctaaagca 1636921 accgttcacc ggcgttttca ggaatacata gagaatgaag agactgcaga gtgaatcagt 1636981 tgtaaaactt tttttgatct agtactatat agacaaaatg caataaagga gtttaacatg 1637041 atttcaaacg cgaaaattgc cagaattaat gaacttgctg ccaaagctaa agctggcgtt 1637101 attacagaag aagaaaaagc cgaacagcaa aagctccgtc aagagtactt gaaaggtttt 1637161 cgttcttcta tgaagaacac gttaaaaagt gtgaaaatca ttgacccaga aggcaatgat 1637221 gttacaccag aaaagctaaa aagagaacaa agaaataaca aacttcacta atataagagg 1637281 aatacggcaa tatcgtattc ctcttttgca tatactataa tcaaaactct tatgtgacaa 1637341 aattcaacaa gtttctctca aatttaagct gaaacagttg agaaaaagtc gtcagacatt 1637401 tatgatgtaa gggtacaaca cataaggaag gggattttta tggatacaat tgaaaagaaa 1637461 tcagttgcta ccattcgcac actgtcaata gacgctattg aaaaagcaaa ttctggtcac 1637521 ccagggatgc cgatgggagc cgctccaatg gcatacacgc tgtggacaaa atttatgaac 1637581 gtaagtccgg caaaccctgg ctggtttaac cgtgaccgtt ttgttttatc tgctggacac 1637641 gggtcagcac tattatacag catgcttcat ttaagcgggt ttgatcttag tattgaagat 1637701 cttaagggat tccgccagtg gggcagcaaa acaccaggac atccggaatt cggacatact 1637761 gccggtgttg atgctacaac aggtccgctt ggccaaggaa ttgccatggc agtcggtatg 1637821 gcaattgctg aacgccattt agcggaaaca tacaaccgcg attcatttaa cgtagtcgat 1637881 cattatacat acagtatttg cggtgatggt gatttaatgg aaggtatttc ttctgaagcc 1637941 gcttcactcg caggccatct tcagcttggc cgtctgatcg tactatacga ttctaatgac 1638001 atctctcttg atggagacct cgaccgttca ttctctgaaa acgtgaaaca gcgttttgaa 1638061 gcaatgaatt gggaagttct ttatgttgag gatggaaaca atattgaaga attaacagcg 1638121 gctatcgaaa aagcacgcca aaatgaaaag aaacctacat taattgaagt gaaaacgaca 1638181 atcggattcg gttcacctaa ccgtgccggt acatccggtg ttcacggtgc gccgcttggt 1638241 aaagaagaaa gcaaattaac aaaagaagct tacgcgtgga catatgaaga agacttctac 1638301 gttccgtcag aagtttatga gcatttcgct gtagctgtta aagaatcagg tgagaaaaaa 1638361 gaacaagaat ggaatgctca attcgctaaa tataaagaag tttatcctga acttgctgaa 1638421 cagcttgaac tggcaatcaa aggagagctt ccgaaggact gggatcaaga ggttcctgtg 1638481 tatgaaaaag gaagcagttt ggcatcccgt gcatcttccg gtgaagttct caacggactt 1638541 gcgaaaaaaa ttcctttctt tgtcggaggt tctgctgacc tagcgggatc gaacaaaacg 1638601 actattaaaa atgccggtga ttttacagcg gttgattact caggcaaaaa cttctggttt 1638661 ggtgtacgtg aatttgcgat gggtgcggcc ttaaacggta tggcgcttca tggcggtctt 1638721 cgtgtattcg gcggaacttt ctttgtcttc tctgattacc tgcgtcctgc gattcgcctt 1638781 gcagcgttaa tgggccttcc tgtgacatat gtcttcacac atgacagtat tgcggttggt 1638841 gaagacggtc cgacgcacga gcctgttgaa cagcttgctt cactccgtgc gatgcctaac 1638901 ctttctttga tccgtccagc agacggcaat gagacagcag cagcatggaa gcttgcagtg 1638961 caaagcactg accacccaac agcgctagtg cttacacgtc aaaaccttcc taccatcgat 1639021 caaacatctg aagaagcatt ggcaggagta gaaaaaggtg catatgtcgt ttctaaatct 1639081 aaaaacgaaa cacctgacgc tcttctcatc gcttccggat cagaggtagg tcttgcaatt 1639141 gaagcgcagg ctgaattggc aaaagaaaat atcgatgttt ctgttgtcag catgccttca 1639201 atggaccgtt ttgagaaaca atctgatgaa tacaaaaacg aagtccttcc tgcagatgtg 1639261 aaaaaacgtc ttgcaattga aatgggctca tcatttggat ggggcaaata cacggggctt 1639321 gaaggtgacg ttctcggcat agaccgattc ggtgcatctg ctcctggtga aaccatcatt 1639381 aacgaatacg gcttctcagt tccgaacgta gtgaatcgag ttaaggcatt aatcaataag 1639441 taagcttttg aaagaggatg agtcaaatca tcctcttttt cttgtttatc cgacaaaaat 1639501 agtattggct gtttaacagt aatagacaat tctttctttt cttcttttgt ataatagaga 1639561 gcaaatgaaa tgctgctgga aaaggggatg aaaagatgga acgtcactac tatacgtacc 1639621 tgatcaaaga ggaatttgcc aatcactatt tcggccggga atcggttatg tttgagctgt 1639681 ttcaagacta tcattggaca agccttgaaa agcagcagta tgaaatgaca gagaaacaga 1639741 ttcaatatat tacacaacca atcccgattt tacatatgca tcagcggtta aaaatgaatt 1639801 taaacaagac ggattacagg cagctggatt atatttatag aatagctttg ccgaaagcaa 1639861 aaggccacgc gacgtttatg atgaaggagc acatgataga aattgtggct tcgggagatt 1639921 acgaggcaga aacgatattc tttgaagtgt taagaaaagt aagcccttgc tttttagcaa 1639981 tggatttcaa ttcgaagcgt tacggatggc taaatccggt gaaagaaaga aattttgtct 1640041 aaaaccgaag aaaaagagat gtaaatgttg tataatagct tttggtttag tacactttaa 1640101 actagacaac atgaaggagg aaataaaatg actttatggg ttggcatcct agtgggcgtt 1640161 gttgcattgc tcataggtgt tgcactcggg ttttttattg ctcgtaaata tatgatgagc 1640221 tacctgaaaa agaatccgcc tattaatgaa caaatgttac gcatgatgat gatgcaaatg 1640281 ggaatgaaac cttctcaaaa gaaaatcaat caaatgatga aagccatgaa taatcaaacg 1640341 aaataatacg taaagattat gatatagaga aacatggtta taaaataaaa aacccttata 1640401 cgggtttttt attttgcaat cattcatcac ccgctactgc tcgaaggcgc tgcttttgat 1640461 attgtatgag aagatggtca agctcctgac tgagctctat cgtaatatga gatgtcattc 1640521 cgttcgccat gacaatttgc agcagctctg ctcttttttt ttcaatttct tttaatagat 1640581 gctctctaat cacagggatg tatcctttca tacattagat cttcaaagtg aatgtttata 1640641 ttatatccat atttatacta attttcaaat gagaaggagt ataatgtctc aatgtcaaat 1640701 taaattatat aagttttttc tgaaaataga aatccttcaa gtgaaagtgt taaaaaaatg 1640761 aaatgatttt gtcataactt gaaggaatgt caaatcatga agggatgatg acatgggaga 1640821 cgtgaattat tttttgacat tcggagcggg gtttttatcc tttatttcgc cttgctgcct 1640881 gccgctttac ccagcttttt tgtcatatat tacaggggtc agcatggacg atgtaaaaac 1640941 tgaaaagctg ctgctgcaga aaagaagctt gtttcatact ttgtgttttt tgcttggctt 1641001 ttcagtcatt tttattgctt taggctatgg aacatctttt attggcagcc tgtttaggga 1641061 ttatcacgat gcgattcggc aaattggcgc gttgcttatt attttgttcg gtttcattac 1641121 actcggtgtg ttccggcctg aggctatgat gaaagagcgg agaatccatt ttaagcataa 1641181 accaagcggg tttttagggt cggtcttaat cggaatggca tttgcagctg gatggacacc 1641241 atgtaccggt ccgatattag ctgctgttat cacacttgca ggcaccaatc cgggctcagc 1641301 ggtgccatac atgatgttat atgtactcgg ttttgcggta ccgtttcttt tattgtcttt 1641361 ttttatcaca aagctgaagt ggataaggaa gaaccagctt ttcattatga aagctggtgg 1641421 cgttttgatg attgtgattg gtgtgctgtt attctttaat tggatgagcc tgatcattat 1641481 tttgctgtca gatctttttg gaggctttac tggtttttga cggtaaatta ctttcgtact 1641541 actactaatc cttttgtttt tggtacaata agactattat ctgtggaaat cgattgttgg 1641601 aggggaatat gacaagagtt ttagttgtag acgacgccaa gttcatgaga gtgaaaatca 1641661 gagagatctt ggaagaggca aattacataa tcgcaggcga agcggcggac ggtgaacaag 1641721 cagctgacct gtataaaaaa ctgcgcccgg accttgtgac aatggatatt acaatgccgg 1641781 tgaaaaacgg cataaaagcg cttcgtgata tcttaacctt tgatcctaaa gcgaaggtca 1641841 tcatgtgcac cgccatgcgc cagcaaagaa ttgtaacgga agcaattgag ctgggggcaa 1641901 aggattttat tgttaagccg tttgaggaaa caaaagtgct ggaagctgta agccgcgtta 1641961 tgggacatta aagtcatttc ttttcaaaat ggtttttttt attgttttgg agtatagtat 1642021 atagtatcaa cactccgaga aacaaaggaa tgataagtat gatgattata gtttcatcaa 1642081 ttattgctgt gttaatggct gtagctgtga tggtggtcag aataaagtcc tctgacaagc 1642141 ctgtttcacc aaaaaaaatc attcttccgc cgatttttat gagtacggga gcgttaatgt 1642201 ttttatttcc ggtattttgg gtaactggag cagagttttt ggaagcattc actttaggtg 1642261 tgattttctc tatttttcta atcaaaactt ctaagttcga aattaaaaat aatgaaattt 1642321 acatgaaacg ctctaaagca tttgttttta tattagtcgg tcttttggtg atcagaatcg 1642381 tgatgaaatc gatcttgagc acatcaattg attatggtgc actgagcgga atgttttgga 1642441 ttctggcttt cggtatgatt gtgccttgga gaatcgccat gtatttatca tatcgaaaac 1642501 ttcataacga gctgcagtca tctaatattc aaatgaatta aaaaaccttt cctcttgtca 1642561 ggaaaggttt tttatttgag aagggtctga taaggttcca aatcgatttt tttgtcccgc 1642621 agatgccttt ttaagaaggt atggtctctt ttaggagttg cgagaatata gcctttgatc 1642681 ataagttgct gatcaatctt tgctaccttt tcttttaatg caagctcacc gattttgcct 1642741 gcgattttag cttttgctgc atctctgaac agctctggca cgggcgcagt caattcatct 1642801 agaaactgtt tgttttcatc gttccataaa tgtctgctgt tttcaatata gtaatcctgc 1642861 caatcaagct ctgatctgcc gtcctctttt ggtaaacgct ttaaaaactt tcgaaacatg 1642921 aaaaaaccgc cgattgataa taagactacc atcatgatta cccaaaacag aataaaccat 1642981 aaaaaccatc cttccagcat caatcattcc cccttattct aaccatattg tatacgaaga 1643041 gagattagaa gaacacagta aaaaaagaat agaaaaaagt gatagacgtc tagtcaaaag 1643101 agatagtaga tcatattcta ttgtatagtg aatctgctat ttggccatgg gagagtcact 1643161 agagggtatt tgacgataaa tggacggaaa aaaagtcact ttcataatag gggatgaaag 1643221 tgacttttta tgtttagctg agaggaaatt gaagagaaaa agaagagcca tcttctgttt 1643281 ctttattgac ggcgactgtg agtatttgat tttcgcattc gacttgaatg tttttgtcat 1643341 taaaataaaa aggaagcatc atttgttttt caaaagtctg tcctgacgat ttgacagtta 1643401 agatgaactc gcatccagaa agggtaactg ttacttgtgt aggctgtaaa aaagtcagat 1643461 ccgcttctat aatatactgc tgacttgttt catataaatc aataggcaat gtttcgtcgt 1643521 accaggcgaa ggggtcttca aaaaattgcc gaagccattc atccatacta tcgaaatcat 1643581 tcgcatcgtt gcgttttgaa tggttcatgg aagcattcct ccacatatca accttgcttt 1643641 acatcatatg cggtggatta taaatgggtg aacgcataaa aaaacagaca ctaaggtctg 1643701 cttttcttac atatcatggc ttgagttgtg cttttgtctt gtatggtttc ggttttttac 1643761 ttttttgctt ccgcttagag gctcgggttg gccgggattg tgtcctttag gggcgttttt 1643821 atgcatatct ttacttgtat tcttattggt cataaaatga gaacctcctt aaaagagttc 1643881 ggtgttattg attggttttt ctttttttgt tattttggcg ttctgcttca gtcagtacaa 1643941 gctggtcgtt ttcaatatag ccggcgcctt tgccttggct ttttgcgtca ttcattccgt 1644001 taatgacgtg attcgctttt cttttgacca tcattatcac ctcaatcata atatggcttc 1644061 ttttattgtg ttatatgaga gagcgtaaac agtaaaaatt accggtacat ttttctcata 1644121 agtcgaactt attgtattta ataaaaacat tgatatttac ttatgtatga ttttgtttta 1644181 atatgaaatt gtgagaaaat tgtgatggaa tgtaatgttc atctgagaat gatctgatct 1644241 gaagggggat tttggagaat ggcaaacgag caaaaaactg cagcaaaaga cgttttccaa 1644301 gcgagaaaaa cgtttactac aaatgggaaa acatatcatt actactcttt aaaagcgtta 1644361 gaagattcag gtataggaaa ggtttcgaag cttccttatt ccatcaaagt tcttttagaa 1644421 tcagtattgc gtcaagttga cggcttcgtt atcaaaaaag aacacgtgga aaatttggca 1644481 aaatggggaa ctgccgaatt aaaggatatc gacgttccgt tcaaaccgtc tcgtgttatt 1644541 ttacaagact tcacaggggt tccggcagta gtagatctgg cttcactgcg taaagcaatg 1644601 gcagctgtcg gcggagatcc tgataaaatc aaccctgaaa ttcctgttga tctcgttatc 1644661 gatcactctg tacaggtaga taaagcgggt acagaagatg cattagcagt aaatatggac 1644721 ttggaattcg aaagaaatgc agagcgctac aaatttttaa gctgggcaaa gaaagcgttt 1644781 aacaattatc aggcagtacc gcctgcaaca ggtattgtgc accaggtcaa ccttgagttc 1644841 ttggcaagtg ttgtccatgc cattgaagaa gacggcgagc ttgtaacgta tcctgatacg 1644901 cttgtcggaa cagactcaca cacaacaatg attaacggta tcggtgttct cggctggggt 1644961 gtcggtggaa ttgaagctga agcgggaatg cttggacagc cttcttactt cccagttcca 1645021 gaggtaatcg gcgcgaaact tgtcggcaag cttccaaacg gaacaacagc tactgacttg 1645081 gcgttaaaag taacacaagt gctgcgtgaa aaaggcgttg tcggtaaatt tgttgaattc 1645141 ttcggaccgg gaattgctga actgccgctt gcagatcgcg caacaattgc gaatatggct 1645201 ccggaatacg gtgctacatg cggattcttc ccagtagatg aagaagcgct taactacctg 1645261 cgcctgactg gccgtgatcc tgaacatatt gatgttgttg aagcatactg cagaagcaat 1645321 ggcttgttct acactccaga tgcggaagac cctcaattta ctgatgtggt tgaaattgac 1645381 ctgtctcaaa ttgaagcaaa cttatcgggt ccaaagcgtc ctcaggattt gatcccgcta 1645441 tctgctatgc aggaaacgtt taaaaagcaa ttagtcagcc ctgcaggtaa ccaaggattc 1645501 ggtttaaatg ctgaggaaga aaataaagaa attaagttta aactccttaa cggcgaagaa 1645561 acagttatga aaacgggtgc gatcgccatt gctgcgatta caagctgtac aaatacatca 1645621 aacccatacg tgctgatcgg cgccggactg gtagcgaaaa aagcggttga gttagggctt 1645681 aaggtgccta attacgtgaa aacgtcactt gcaccgggtt ctaaagttgt tacaggatat 1645741 cttgtgaatt caggccttct tccatacatg aaagagcttg gctttaacct cgttgggtac 1645801 ggctgtacaa catgtatcgg gaactcaggt ccgctttcac cggaaatcga agaagcggtt 1645861 gcgaaaaatg atcttctgat tacgtctgtc ctttccggaa accgtaactt tgaaggacgt 1645921 attcacccgc ttgttaaagg caactatctt gcttcaccgc cgcttgttgt ggcatatgcg 1645981 ctggctggaa cggtaaacat taacttaaaa accgatccaa tcggtgtggg caaggatggt 1646041 caaaacgtat actttaatga tatttggccg tcaatggacg aaatcaatgc acttgttaag 1646101 caaactgtta cgccagagct attccgcaaa gagtatgaaa cagtatttga tgacaacaag 1646161 cgctggaacg aaattgaaac aacagatgaa gctttatata aatgggataa cgattcaact 1646221 tacatccaaa acccaccatt ctttgaagag atgtctgttg agccaggcaa ggttgagcca 1646281 ttaaaaggac tgcgtgttgt cggtaaattc ggcgattcag tcacaactga ccatatttct 1646341 cctgcggggg caatcggaaa agatacgcct gccggaaagt atttgcaaga aaaaggtgtt 1646401 tcacctcgtg actttaactc ctacggctcc cgccgtggaa accatgaagt catgatgaga 1646461 ggaacatttg ccaacattcg catcaaaaac caaatcgcac cgggtacaga aggcggattt 1646521 acgacgtact ggccgactgg tgaagtaaca tccatctatg atgcatgcat gaaatacaaa 1646581 gaagataaaa ccggtcttgt cgtattagca ggaaaagact atggtatggg atcttcacgt 1646641 gactgggctg caaaaggaac aaaccttctc ggcatcagaa cggtcattgc agagagcttc 1646701 gaaagaattc acagaagcaa tcttgtattc atgggtgtgc tgccgcttca gtttaaacaa 1646761 ggtgaaaatg cggatacact cggcttaacg ggtaaagaag tcatcgaggt agatgttgat 1646821 gaaacagttc gtcctcgtga ccttgtgact gtaagagcaa tcaatgaaga cggcaatgta 1646881 acaacttttg aagcagtcgt ccgctttgat agtgaagttg aaattgatta ctaccgccat 1646941 ggcggcatcc ttcaaatggt gcttcgtgaa aaaatgaagc agtcctgatg aatcaatagg 1647001 aagagaaggc atttcgcttt ctcttctttt tatgacacaa tgtgctgcgg aggtggcata 1647061 tgctgaaaaa atggctcgca gggatcctgc ttatcatgct agtcggttat acgggatgga 1647121 atttatatca aacatacagc aaaaaagaag tcggaattca agaggggcaa caagcacctg 1647181 atttttcttt gaaaacgcta tcaggagaga aaagctcttt acaggatgca aaaggcaaaa 1647241 aagtgctgct caatttttgg gcaacttggt gtaagccgtg ccgtcaggaa atgcctgcga 1647301 tggaaaagct gcaaaaagag tacgccgaca aacttgcggt tgttgcggta aatttcactt 1647361 cagctgagaa aagtgagaaa caggtccgag cgtttgctga tacttatgac ttaacgttcc 1647421 ccattctgat tgataaaaaa gggatcaatg ctgactataa cgtgatgtca tatccaacga 1647481 catatatctt agatgaaaaa ggtgttatcc aagacataca tgttggcacc atgacaaaaa 1647541 aagaaatgga acaaaaactg gatcttgatt agattcagtt ttttttatac tcaaatatgc 1647601 ttacaagttt tcagaattgg aaaaaataaa agaatatgcg gaggtgagaa gcgtgaagaa 1647661 gatgagaaaa cgttcttttc atgagctcgt catggaaaac aaaaaagagc tgatgaccaa 1647721 tacagagtat ttaaatcagc ttgaggaaaa gcttgaacag cgatttaagc aaaaataacc 1647781 tttaatttgt attcatgttt acccctcctt ttgagaaacc tatctgttga ggagggataa 1647841 acatgggaaa caacaagaaa aacggtcagc ctcaatatgc tccaagccac ttgggtacaa 1647901 agcctgtaaa atataaagcc aataaagggg aaaaaatgca tgatacttca ggacagcggc 1647961 cgattatcat gcagacaaaa ggcgagtagc gaaaattcga gtttatttct aggaggtaca 1648021 tccgaatgac aaagaaccaa aatcaatatc agcagcctaa tcctgatgat cgttctgaca 1648081 atgtggaaaa attgcaggat atggttcaaa atacaattga aaatatagaa gaagcagaag 1648141 catcaatgga gtttgcttca ggagaagata aacagcgtat caaagaaaaa aatgcaaggc 1648201 gcgaacagag cattgaagcg tttcgtaatg aaatacagga cgaatctgca gcgagacaaa 1648261 acggataccg ttcttaaaaa accagggaaa cctggttttt ttctttctga tttgattatg 1648321 gtaaaatggg gctaaattga cgttaaggga gcagagtaat cttgcatgta tcaaaaaaag 1648381 aaatagaagt gcgttatgca gaaacagatc aaatggggat tgtctatcac gcaaattatc 1648441 ttgtgtggat ggaggtcggc agaacggcct tgattaagga cttaggcttt ttatatagtg 1648501 atatggaaaa aaaaggcgtt ctgtccccag tcgttgatat caatatttcc tataaaaagc 1648561 cgcttcatta cggagaaacc gcggttgtac atacatggat agaggactat aacggattta 1648621 aaaccgtcta tggttaccac atttataatc cggccggtga gctttccatc aaagccacct 1648681 catctcatat ttgtgtggat aaagaaagct ttaagccaat tcaattccgc aaagcttttc 1648741 ctgattggca cacagcatat gaaaaggcca aaaaataggg aagtgaacgg gatatggcgt 1648801 ttggtgtgaa acgggaggaa cttaaccggt ggaaacaagc agtgaaaaga ggagaaatcg 1648861 catttttaac acattactgg ctggatgacc gatttccaga agcaaagacc gtgacaaaag 1648921 ccggctgtgc agacattgat aagctggttc agtggggagc ggcgtacggg ttaaaaaaag 1648981 aatggatcca taagaaaagt gaatttcccc actttgatct gctgggggaa acacaaaaat 1649041 atattttgga acaagaaaac ctaaccgatc atcttatacg atttcatttg taaaaaaaga 1649101 acgcacatga agtgcgttct tttttattgg tattcaaaaa ccggttcatc agcgtcttct 1649161 gaatagctga cgagaaggtc gtggttatca aagtaccata aatcactttc ttcaataaag 1649221 aaggtaatgc catcagcttc tgcagtgact ccagcctctt gtggggcatc tttcgctaca 1649281 ccgagagaaa aacccttttg aacgttgctg cagcctccat agcggacgaa aaagcgaacc 1649341 tggtctccgc tttccaaatc gagttcttct ttataccagt tcaatgcgtc ttcgttaatt 1649401 gtcatattca taacagaaca cccctttgtt cttcatttga attttctcta ttataaacgt 1649461 attaggctat tctgtgtcaa aagagaagtt ttttaagctt ataaccattt tactttaggt 1649521 tctgttttat tgataattcg tttaatgttc gctcggtgtc tgtatatcac aaaaatagtg 1649581 agcagggtaa cgacaatcaa taaatacgta tcatggacaa agaaactata tataacagta 1649641 tagatccctg ttaacatcga tgagagagaa acaaatttag tcaagtataa aaagatgaag 1649701 aataccgcaa ccatcgtgat aaataacagg ggtgcgtaaa atagcaaaac gcctcctgat 1649761 gtcgccacgg ctttaccgcc tttaaatttg gcgaagatgg gaaacacgtg gcctaaaacc 1649821 gcaaagactc ctgcaagaag cgggtgaata tcaacatgca tgagaaaagg caatgcagtt 1649881 gccagtgtcc ctttcaaaat atctccggct atgacgaccg aaccagcttt tacacccaat 1649941 gtacggaatg cattggtagc gcctaagttg ccgcttccgt gctcccgaat atcaattcct 1650001 ttggcaagct tgcccacaat taagccagat ggaatgctgc ctatcaagta ggccaaaata 1650061 atcaataaag caattaacat ctacatttct cctttttcaa attcccttct ttttatttta 1650121 acatgagatg tcatgatctg atgataagtt tttttgtaaa gtttgcttac aaatcaaatc 1650181 aaacatgcat catattttga tttctcctgt tttgatcgtg taaaataagt gaaaaaggag 1650241 tgacacacga tgcaaaaccc ttctaaagcg gaaattaaag agattcttca aagaagcaaa 1650301 cgtatagcgg tagtagggct ttcagaccgt ccggatagaa cgtcacatat ggtttcaaaa 1650361 gcaatgcagg acgcgggtta tgaaattatc cctgtgaacc ctacaattga tgaggcgcta 1650421 ggtgtcaaag ccgtttcatc tttaaaagag atagacggtc cgattgacat cgtaaatgta 1650481 ttccggcgct cagaacagct tcctggagtg gcggaagagt ttttagagac agatgcgcca 1650541 gtattttggg cacagcaagg gctagttaat gaggaagcat accagatgct aaaagaaaaa 1650601 ggcagaacgg ttatcatgga tctgtgcata aaagtggcac acgctgtaac aaaataggtg 1650661 cagaactgca aaaatccttg taaattcaag gatttttgct ttttaatttt aagatattgt 1650721 ttgcgtatta cggtgaaaca gatacaataa agcttgaaca gctttttttg aataccttgt 1650781 ccagctgggt ttcggccgtt cgatttgcga aggtctgctg ctttatatat aataaacaaa 1650841 catacgttct catagtgtaa aaacagcact agccgatgtt ttgagaagaa ctgattcgtt 1650901 agctctatgt tgcgattgca aacatattgg ttataatgag gagtccaagg cagtactggc 1650961 tcgaggcgag gtttataaaa aatatcttat atacaaatga tgtgtaacac tgaaaagaga 1651021 aagacaatgt tagtttttga aaggggtttg tacgtttggc tagaaaacag caatttgatt 1651081 acaacgaaga tgccatacag gtgctcgaag gccttgaggc tgtcaggaaa aggccgggta 1651141 tgtatattgg ctctactgac gcgcggggtt tgcaccactt ggtttatgaa attgtagata 1651201 actctgtcga cgaggtgctt gccggccatg gagatcacat aatcgtcaaa atacataaag 1651261 acaatagtat ttctgtacag gatagaggcc gcggcatgcc gaccggaatg cataagctcg 1651321 gcaaaccaac ccctgaagtg attttaacgg tgcttcatgc cggagggaaa ttcggccaag 1651381 gcggctataa gacaagcggc gggctccacg gagttggtgc atcagtcgtg aatgctttat 1651441 ctgaatggct gacggttacc attgagcggg acggttttgt ctatcagcag cgatttgaaa 1651501 atggaggaaa accggttaca tctctcgaaa agatcggcaa aacaaaaaag acgggaactc 1651561 ttacacactt taagccagat ccaacgatgt tcagcacaac cacttataat tttgaaacgc 1651621 tctctgagcg cttaagagag tctgcgtttt tgttaaaagg actgaaaatt gagctgattg 1651681 atgaacgcaa tgaccagcgt gaggtctttt attatgaaaa cggcatagaa gcgtttgttg 1651741 cttacttaaa tgaagaaaaa gacgtcttgt ctgaagtggt ctcgtttgag ggtgagcatc 1651801 attctataga agtggacttt gcgttccagt ttaacgatgg ttattctgaa aatattttgt 1651861 cgtttgtcaa caatgtcaga acaaaagacg gcgggacgca tgagtcaggt gcaaaaactg 1651921 cgatgacgcg tgcttttaat gaatatgcgc gaaaagtggc tttgctgaaa gaaaaggata 1651981 agaaccttga aggcaccgat ataagggaag ggctttcagc cattatttct gtccgcattc 1652041 ctgaggagct tcttcaattt gagggacaaa caaaaggaaa gctcggtacc agtgaagcaa 1652101 gatcagcggt ggatgcgatt gtttcagagc agcttgctta ctttttagag gaaaatcggg 1652161 acaccgcaac gcttcttgtc aaaaaagcaa tcaaggcgag ccaggcgcgc gaagcggcac 1652221 gcaaagcccg tgaagaagca agaagcggca aaaaacgaaa aaaatcagaa gcgactttaa 1652281 gcggaaagct gacgcctgcg ggttcaagaa acccggcaaa aaatgaattg tatctcgttg 1652341 agggagattc agcaggcggg tcagccaagc agggacgaga ccgcagattc caggcggttc 1652401 tgcctttacg cggtaaagtc attaatacag aaaaagctaa gcttgctgat atctttaaaa 1652461 atgaagagat caatacgatc attcatgcga tcggcggggg agtcggggca gatttctcaa 1652521 tcgatgacat caactacgac aaaatcatca ttatgaccga tgccgatact gacggcgccc 1652581 atattcaagt gctgcttctt acctttttct atcgctatat gaaaccgctc attgagcatg 1652641 gcaaggtgtt cattgcgctg ccacctttat ataaggtcag taaaggaagc gggaaaaagg 1652701 aaatcattga atatgcatgg tctgatgaag agatggggga tgtcctgaaa aaagtcggca 1652761 aaggctatac cattcaacga tataagggtc ttggagagat gaacgcagac cagctgtggg 1652821 aaacgacgat gaatccggag tcccgcacac ttgttagggt caaaattgac gatgcggcac 1652881 gtgtagagag acgtgtgacg acgttaatgg gagacaaagt agagccgcgc agaaagtgga 1652941 ttgagaaaaa cgtcgctttc ggcttagatg aagaaagcaa tattttagaa aatgaaaact 1653001 tatcggtcgc tgaggaggtt taatgattgt cacagccaga attatttcat gatttaccat 1653061 tagaagaggt gatcggcgac cgttttggac gctacagtaa atatattatt caagacaggg 1653121 cgctgcccga tgcgagagac ggattaaagc cggtacagcg cagaattctg tatgcaatgc 1653181 atacagatgg aaacacgttt gataaaaact tcagaaaagc ggccaaaacg gtcggtaacg 1653241 tcatcggtaa ctatcatccg cacggtgaca gctcggttta tgaagcaatg gtgcggatga 1653301 gccaggattg gaaagttcgt aatgtgttaa tcgaaatgca tggaaacaat ggaagcatcg 1653361 acggagatcc cccggcagcc atgcgttata cagaggcacg attatctccg atagcatctg 1653421 agcttcttcg ggatattgac aaaaacacgg ttgaatttgt gccgaacttc gatgatacaa 1653481 gcaaggagcc tgtcgtactc ccggcgatgt ttcctaacct attggtcaac ggatctaccg 1653541 ggatttcagc aggatacgcg accgacattc cccctcatca tctgggagaa gtcattgatg 1653601 ctgtcattaa gcgtattcaa atgccttctt gctctgttga cgaactcatg gaagttatta 1653661 aagggcctga ttttccgaca ggcggtatta ttcagggcgt tgacgggata agaaaagctt 1653721 acgaaaccgg aaaaggaaaa atcattatcc gcggaaaggc tgaaattgaa acaatcagag 1653781 gcggacgaga acaaattgtc attactgaaa ttccatttga agtaaataaa gcaaaccttg 1653841 taaaaaaaat ggacgagttc cgtattgata aaaaggttga aggcatctca gaggttcgtg 1653901 atgaaacgga tcgaacaggg ctgagagtgg tcattgaact gaaaaaagaa gctgatgcca 1653961 aaggcatttt gaatttctta tataaaaata ctgatttgca gatcacatat aacttcaata 1654021 tggtggctat ccataaccgc cgtccgatgc tgatgagcct gccgtctatt ttggatgcat 1654081 atatcggaca ccaaaaggaa gttgtcacaa accggtccgt ttacgagctt caaaaagcaa 1654141 aagacagaca tcatatcgta gaagggctca tgaaagcttt gtctattttg gatgaagtga 1654201 ttgcaacaat ccgttcttct agcgataaac gtgacgctaa aaacaatttg atcgcgaaat 1654261 atgaatttac agagcctcag gctgaagcca tcgtgtcatt gcagctatat cgtttaacca 1654321 ataccgatat cacagcgctt aaggaagagg cagaagagct cggtaaaaaa attgaagagc 1654381 tcgaatctat tctgagcaat gataaaaaac tgctaaaagt gattacaaac agcttaaaag 1654441 cactgaaaaa gaaatatgca gatacgagac gctccgtgat tgaagaaaaa attgaagaaa 1654501 ttaaaatcaa tctcgaagtc atggttgcat ctgaggatgt atatgtaacc gttacgaagg 1654561 atggttacct aaaacggacg agccagcgct catttgccgc ttccaacggt caggacttcg 1654621 gaatgaaaga tacggacagg atgctgcatc agtttgaaat gaatacgaca gacgtgctgc 1654681 tgctctttac gaacaaagga agctacatct attgtcctgt tcaccagctg cctgatatca 1654741 gatggaagga catgggccag catttttcaa atctaatcac tattgaccgt gatgaaacga 1654801 ttgtaaaggc tataccgata aaagaatttg atccgtcggc atatcttcta ttctttacga 1654861 aaaacggtat ggtgaaaaag acagagctca ctcattataa agcacagcgt tattctaagg 1654921 cacttgtagc cttaaatctg aagggtgaag atgaactgat tgatgtacat gtaacaaatg 1654981 gggaaagcca gatctttatg gccactcact tagggtatgg tctatggttt ggagaagacg 1655041 aagtgaatgt agttggcgcg cgtgcggcag gtgtcaaagg gattaactta aaagaggatg 1655101 actttgttgt ctccggtgag attcttcagc aatctgattc aattgtcttg ttcacacagc 1655161 ggggagcggt taaacgcatg agtctttctg agttcgagaa gacatcccgt gcaaaacgcg 1655221 gtgtcgtaat gctaagggaa ctgaaaaaga atcctcaccg tgttgtagca ctgttcgctt 1655281 gcggtcttga acagcgacta atggcagaaa cagaaaaagg cgacagaaaa gaactgcaga 1655341 caaaagagtt gcggacaaac gacagataca gcaatggctc tttctttttt gatgaagagg 1655401 aatcaggcaa ggttacagct gtttggcgcc ttcatacaga acaataataa aaaacccgct 1655461 catactatat gagcgggttt cgtttgtttt ttatcagctt tcatggttgg tgaatagatc 1655521 tgttacagca tgaatgactt caatcccctg ccatacaaat aaattcagcg ctgtgaaaga 1655581 aaataagcct aaaatcacca ttcttaagat aaacaacatg tttaacagcc tcctcatatt 1655641 ttcgttacat aatcgggtga tgttgaacat gaagtttgcc gaaataagac gattgataaa 1655701 atttggccag tataaagctt tttttccgct gacgtctgcg ggagtatccc gtacttttgc 1655761 tttcagcggt cagcagcaga acagccattg cccataaagc ggtcagcgta aatgcccctg 1655821 tgatggattt cttctcatca tcagcatttt ggccggcttt catctcatgc atttcctgct 1655881 ggtcggctac ggctttataa tgatggccga tatcaaaggc gtggggaatt gagaacaaat 1655941 gaaaactggc aatcgccaag aataagatgg atgctttcaa tatcgttact tttttcaaat 1656001 gatctccccc tcctttaata ttactgaata tttttataat aataccccaa tccatcctaa 1656061 aagtaaacct gatttattaa atttaaaaat aaatttaact ttgttaagta tatatctttt 1656121 tgcttatttt tgaaagagaa aacttctttt attagcgtat gtatacccgg tttatggtgt 1656181 gaataaaaac atattttaaa tgatatgttg tttaggattt attactttat ttatgtgtaa 1656241 atcaaagaga aaggcaagag aatgggaaga aatgattaca ttgttaatag ggtactcttt 1656301 ttttaaagcc agtttgcaag gaatgttttt attcgtagga aaataataga gaaggggtcg 1656361 acagagtaac atctggctat gacaatattc ttctcgaaaa aacttcctaa ttcgtcatat 1656421 tgtgatataa taaaactcgt tatgttaaaa aatctaacat caaaatcgaa ttcgtattga 1656481 attgatgaaa acgggaggta aatatggagt cttttttcaa tagtttgatt aatattccaa 1656541 gtgatttcat ctggaaatac ctattttata ttttaatagg gcttggatta ttttttacca 1656601 tacgttttgg ttttatccaa ttccgttatt ttattgaaat gttcagaata gtaggggaga 1656661 agccggaagg aaataaaggt gtttcatcta tgcaggcatt ctttatttcg gccgcatccc 1656721 gagtcggcac agggaatttg actggtgtag ccttagcaat tgcgacaggc ggaccaggcg 1656781 ctgtattttg gatgtgggta gtggctgcag taggcatggc ttcaagcttt gtcgaaagta 1656841 cattagcaca gctttataag gtaagagacg gggaggattt ccgcggaggg ccggcctact 1656901 atattcaaaa gggtcttggt gccagatggc ttggcatcgt ttttgcaatc ttaattaccg 1656961 tctcattcgg cttgattttt aacgctgttc aaacaaatac aattgctgga gcattggatg 1657021 gcgcattcca tgtaaataaa atagttgtag ccatagttct ggcggtttta actgcgttta 1657081 tcattttcgg cggtttaaaa cgtgttgtcg ctgtttcaca gctaattgtg ccggttatgg 1657141 caggcattta tattcttatc gctttatttg ttgtcatcac gaatattacg gctttccctg 1657201 gcgttatcgc tacaattgtt aaaaatgctt taggttttga acaagtcgtc ggcggcggaa 1657261 taggcggcat catcgttatc ggtgcgcaac gcggactttt ttcaaacgaa gcaggaatgg 1657321 ggagcgcacc aaacgcggct gcgacggctc atgtatccca tccggcaaag caaggcttta 1657381 ttcaaacatt aggcgtattt ttcgatacat ttatcatatg tacgtccaca gcatttatta 1657441 ttttgctgta cagtgtaacg ccaaaaggcg acggcatcca agtcacacag gctgctctta 1657501 accatcacat tggaggctgg gcgccgactt tcatcgcagt cgcaatgttc ttgtttgcat 1657561 tcagttcagt tgtcggcaac tattattatg gcgagacaaa cattgaattt attaaaacaa 1657621 gcaaaacatg gctgaacatt taccgtatcg ctgttattgc tatggttgtg tatggatctt 1657681 tatcaggctt ccaaatcgtt tgggatatgg cggacctctt tatgggtatc atggcgctga 1657741 tcaacttaat tgtgattgcg ctgctgtcaa acgttgctta caaagtgtat aaagattacg 1657801 cgaaacagcg taagcaagga cttgatcctg tgtttaaagc gaaaaacatc ccagggctga 1657861 aaaacgctga aacatgggaa gatgagaaac aagaagcata atataaatat aaaacaaagc 1657921 tgcattcaat agttgaatgc agctttttca ttattggaaa taaatttaat ttttcgactc 1657981 gaatgaaaaa tgacgtgtaa agtcccaatt cagtccagtt ttctttgttc tatatgtgtc 1658041 atgtgtgtct tattcattgg aggtagagca aattgacagg cttttaaacc tccccaaaac 1658101 aagaaattag gttgatagac aatcatgaga aagattttta caatgagttc gtgctcataa 1658161 gaagtgtaga gccaaaatga tgcgaaggag gaaaagatca gatatgaaac ggtcaatctc 1658221 tatttttatt acgtgtttat tgattacgtt attgacaatg ggcggcatga tagcttcgcc 1658281 ggcatcagca gcagggacaa aaacgccagt agccaagaat ggccagctta gcataaaagg 1658341 tacacagctc gttaaccgag acggtaaagc ggtacagctg aaggggatca gttcacacgg 1658401 attgcaatgg tatggagaat atgtcaataa agacagctta aaatggctga gagatgattg 1658461 gggtatcacc gttttccgtg cagcgatgta tacggcagat ggcggttata ttgacaaccc 1658521 gtccgtgaaa aataaagtaa aagaagcggt tgaagcggca aaagagcttg ggatatatgt 1658581 catcattgac tggcatatct taaatgacgg taatccaaac caaaataaag agaaggcaaa 1658641 agaattcttc aaggaaatgt caagccttta cggaaacacg ccaaacgtca tttatgaaat 1658701 tgcaaacgaa ccaaacggtg atgtgaactg gaagcgtgat attaaaccat atgcggaaga 1658761 agtgatttca gttatccgca aaaatgatcc agacaacatc atcattgtcg gaaccggtac 1658821 atggagccag gatgtgaatg atgctgccga tgaccagcta aaagatgcaa acgttatgta 1658881 cgcacttcat ttttatgccg gcacacacgg ccaattttta cgggataaag caaactatgc 1658941 actcagcaaa ggagcaccta tttttgtgac agagtgggga acaagcgacg cgtctggcaa 1659001 tggcggtgta ttccttgatc aatcgaggga atggctgaaa tatctcgaca gcaagaccat 1659061 tagctgggtg aactggaatc tttctgataa gcaggaatca tcctcagctt taaagccggg 1659121 ggcatctaaa acaggcggct ggcggttgtc agatttatct gcttcaggaa cattcgttag 1659181 agaaaacatt ctcggcacca aagattcgac gaaggacatt cctgaaacgc catcaaaaga 1659241 taaacccaca caggaaaatg gtatttctgt acagtacaga gcaggggatg ggagtatgaa 1659301 cagcaaccaa atccgtccgc agcttcaaat aaaaaataac ggcaatacca cggttgattt 1659361 aaaagatgtc actgcccgtt actggtataa agcgaaaaac aaaggccaaa actttgactg 1659421 tgactacgcg cagattggat gcggcaatgt gacacacaag tttgtgacgt tgcataaacc 1659481 aaagcaaggt gcagatacct atctggaact tggatttaaa aacggaacgt tggcaccggg 1659541 agcaagcaca gggaatattc agctccgtct tcacaatgat gactggagca attatgcaca 1659601 aagcggcgat tattcctttt tcaaatcaaa tacgtttaaa acaacgaaaa aaatcacatt 1659661 atatgatcaa ggaaaactga tttggggaac agaaccaaat tagttaagct tttttttggc 1659721 ggacatcagt aacgatgtcc gtttttatca tctaatagga ggtttgcgtt gtggatgaaa 1659781 tactgaaaca gtatatggtg ctgtataaaa aaatgagtaa tatgataaat ggtcccgact 1659841 atccaggtaa ggaaaaagac atccagcatc aaaaagatca gatcgaagtt tacgaaaaac 1659901 agctgcagca aggattttct acagattatg actatgatgt gtttgctgat tctgttatca 1659961 aatgcgcata tggcgatatg acgctggaag atttagaagc cgtttattat ggattgacaa 1660021 caccattttt ttgatttgtc attcagcagt aaaatttcaa tttctgtctc actaacttaa 1660081 gtatactttg atattgagac agaaatttat ttattttgtt tacttcctag aatatatatt 1660141 atgtaaacta gaaaagatga agaataaagc tttgctgttt ttatgtacat cctttcttct 1660201 tcctgtaatt cagcaacaaa ataaaaaagc gatttcccaa tcggaaaatc gccaattcag 1660261 acactctatt atttatgtgt gtctttgtgc tcttaacgat ttacaacaaa tgttgtcacg 1660321 ctttgagctg gaagatgagc ccaaaaatga ttgcctgata cagtgagatt cgttccaggt 1660381 tgtagattgc tgctgctgct cgtgatccat ctagatacgt ttgaagcaga tccattctgc 1660441 aaaacaaagt tttggttgac tcctgtgttg cttttattga tggcaacaat aacgaccttg 1660501 ttgtcacctt tataggctga cacgtaaacg ttcgcattag ggtttttcgt tgcatcaatc 1660561 cttacatagc cgggacgcac aaactttgag aaatgagcca tattgtagcc gcgtttgctg 1660621 atcgtaccat cttctttcat aggtccatat gatcttcgga tgtaccacca tacataagct 1660681 tgaaagtccc cctctaccat cgcattgtga atatgctgtg aaacatccaa tgcctcaggc 1660741 catcgatccg ccgagttggt atcactgttt ggatagtata cttccgtcat ccaaaggtcc 1660801 ttccccgctc ctttttgttt gaaaagagga taagggaatt ggctgacctg ggtgccgtac 1660861 aggtgagttc cgagaatatc catattggca agagcctgcg gatcgttcaa gatcgggtcc 1660921 gacaaattct tcaagtattg aaatgactca ggcgcaatga cgcgggcatt gatcgagccg 1660981 gcgttttctc tcataaagcg aagtatttct tgcggcgtcc accacgtcca ctcgtgagcg 1661041 taatcaggct cgttttggac cgaaatcgcg taaagattca caccattatt cttcatgaag 1661101 gtaacaaaat cgttaagatg ctgcgcgtat gctgcgtact tgttgtattt cagccgttta 1661161 gccgatgtgt caccattccg attaaaggtc tcaaccatat cacttggagg attccaagga 1661221 gaagcaaaaa cgattgctcc gtgtttgacc gcactctttg cagtctccac ctctttatac 1661281 caattatttc gattttcatc tacatgaatt cttaagattg aaaatcctaa ctggttctgt 1661341 ccattgccaa aagcagtttc tctttgagct gctgtaagat ccccagccca agccggatga 1661401 ttcatccctc caaaaccgcg aatcacttgt ttctctgcag atacattaac tgttacatca 1661461 cttgctgcca aaacttcagt agcgcctggc cctaacatga ctgacagcat agtgaaacat 1661521 actaatagta cacaaattgt tttttttatg cgtggaatca tttattcctc tccttcgtca 1661581 tgtgtctttt acggtattaa aaaatctgca tggcatatcc ataatggcgg gctgttccgg 1661641 tgctggcccg tacttcaccc gcctcgtttt taagcggtcc cattacgagt actatctttg 1661701 cgtaaactgc cagtaatcaa aattaaacaa gtttcctgta cctgttccgg taaatacaaa 1661761 gaatactttg tgcacaccgg ttgccccgct taccgcagtt tctatttccc tccacgtttg 1661821 cgctccgcct gttgaaggca cattcagagt tccaacaagc ttaccgtctg cactgtcgag 1661881 gcgcacttct attttcccgc ctaaagtgga tgctacattt gctttaaatg acctggcacc 1661941 gcccgctccg aagtctgcat ttcctacagc aatccagtct ccattttgaa tgcttgttac 1662001 atgctgatta tttactggcc cgccgggtgc tgtggacttc tctgtcaaaa tgcgtccatt 1662061 ccaagcaaac gtttcagctt ctacccggtt atatgggttt aaattggaaa tttgtgttac 1662121 acctgcataa tttgccgcta cctcttgaat agatccatct gcattatgca ccagcttatt 1662181 aatatgggga gagcggtatc ctttgccggc cccgaacaga gcggaactga cagtttgcgc 1662241 atggtacacc acataccact cgtttttaaa attgaaaaca gcatgatggt tgtttccgcc 1662301 acctccgaaa aatgcacccg gatttttcag gaagtgccct ctatatgtaa agggacccat 1662361 gggacttgaa ctggtcatgt agccgatctc acccgggggt ttatcggccg ggtgcgtgcc 1662421 gccgaaattg atgcaatagg agtaataata tgttccgtta tacttgtgca atcccgaatc 1662481 ttcaaacatg aaaggcgcat caattgtaga tgcacttcca acaacactcg tcatatcagg 1662541 ccccaatttt atgactctag ccgttttagg attggcccat tgtccctgcg ttggatttga 1662601 aacgccagga acgcctccgc cggcatacag gtaaccggtt ccgtcgtcat ctacaaatac 1662661 tgccggatca aaaagccata caacaccaga cattcctggc gtacttggcg ttacgagcgg 1662721 ttttccgatt gggtcggtcc atggaccaat cgggctgtct gcggtgagaa ccccgatacc 1662781 tccgccgctg tttgcgaaat aaaggaagaa tttatccttg ccattaattt ttttaactgc 1662841 gattgacggt gcccatgacg cacctgccca ttttgcaatt ccacggcctc cattagctcc 1662901 attggcacct gctaccggaa tggctccgtg gtctgtccag ttcaccatat ccgctgaaga 1662961 tatgacgaat actctattca aattggcaaa tgaattatct ttaattgttc cgttgctatt 1663021 atattcatag tcatcacttg acatatagat gtagactctt ccgttatagg tcagcgcaac 1663081 cggatccgct cccaaatgat ggtcgataag cggatttgaa ttccctatat gttttgcaat 1663141 tgtagtacta gtggcagcat acgcagactt cccagataag cagctcaata ataaaactag 1663201 aatccataaa catacgctac actttttcct catcacttca catcctcctt tttccttaaa 1663261 atgggggatt ttcttttgga atttgataac aacaggtcac gaagattgca cgcataaagt 1663321 agccggaagc tgtttagcaa tgttcccagt tgttctgaaa gctcatcttc atgtgtctcc 1663381 attctctctt ttcttcgagg agatcgcacc actccttcaa aattgttcaa aaaaacttcc 1663441 ccattcctag cgaccattgt ccagaaaata aaaagacagg attgttcatg gcctcccact 1663501 aatcacattg aacggagatt acatcattat ccaagatatc cctttatcta acatcctaca 1663561 tcattaaaaa aattgtgtat agaaactttt ggaggagtta gtgttcgatt ctacaaagga 1663621 actggataca tttattcatt gataagatgg ggctaacact ccgtttatat ttgtatgttt 1663681 tcagacacaa aaaacagccg ttcaatgcgg ctgttttttt caagagtata agactattga 1663741 gcggtatacc cgctttttca tgttttgttc atattttatt aattgtttat tcaacactgt 1663801 ccgctatagt aatccatatc aacaaatatg actgccactc gcatctttta tgaagggagg 1663861 ttcgttacgc tgaaagaaaa aataaagaca ttaggccgtt tttgcaccgt aggcgtcggc 1663921 aatacgctga tagattttgg tgtcttcttt cttcttaccg cttgtcatgt ctcttatctg 1663981 ccggcgcaga tctgctccta tactgcaggt atcgtcaaca gctatgtgtg gaaccggaat 1664041 tggacgtttt gtgtgaaacg taaggctgac gggaaagaga tcgtgcgttt tctcatgatt 1664101 aatattgccg cgtcagggat cacctttttg ctgctttatt tgtttcaaaa ttgcggctgc 1664161 tcgcttttgg tgagtaagct cgccgccact atcggcggaa tgatgatgaa ttttatcgga 1664221 aaccgaatct gggtatttgg agattcgctg aaaaacatac aggatcagga gtgaagatga 1664281 atgagaaaaa aagtgagaaa agcggttata cccgcagcgg gtttaggaac gagatttctg 1664341 ccggcgacaa aggcgcagcc taaagaaatg cttccaatcg tcgacaaacc agcaatccaa 1664401 tatattgtag aagaggccgc agagtcagga attgaagata tactgattat tacagggaga 1664461 aacaaacgct cgattgaaga tcattttgat cggtcggcgg aattggaatt caatctccgg 1664521 gaaaaaggca agacggagac acttaaggaa atgcagcaga ttgccgattt ggccaacatt 1664581 cattacatcc gccagaaaga accgctcgga ttaggccatg cggtgctgtg tgcggagcat 1664641 tttatcggag atgagccttt tgctgttctc ttaggtgatg atattatggt gtctgaaaca 1664701 ccggctcttc ggcaattaat ggatgtatat gacgtttatg gcacagaggt tgtcggtgta 1664761 cagtcagttc tccctgagga tgtcagcaaa tatggtatta taaatacatc agggtctcaa 1664821 gggcatgtat atgaagtgaa cgatttagtg gaaaagcctt ctcctgaaga agcaccttcg 1664881 gaaatcgcag taatgggacg ttatgtgctg aattcttcga tcttctccgt tttgaagaca 1664941 attggcagag gcgcgggcaa cgaaattcag ctgacagatg cgcttcgtga ggtttgccgt 1665001 aaggagccga tccatgcccg gctgctggaa ggaaatcgat atgacattgg cgataagctg 1665061 ggctgtttta aagcgagcac cgaaatcggc ttaatgcgtc ccgaaatgag atctcagctt 1665121 ttggcctatt tagaagatgt gatcaaacgg gaaacgaaag aaatgctgcg gtaaaaaaat 1665181 tgtaaccatc ttgctcgtca atcagtcata taatagtgaa aaagattagg acaggttgtg 1665241 aagaatgtgg gcagtttgat aagcgaaatt ttaacatggc tgacgaacat gggatatgcg 1665301 ggtattgcga ttgggttaat gattgaaatc attccgagtg agattgtatt agcttatggc 1665361 ggctatatgg tatcggaggg cacgattgga tttattggcg caattattgc gggtgttatc 1665421 gggggcacca ttgcccagat ctttatttac tggatcggtc gctatggcgg caggccattt 1665481 ctggacaaat acgggaagta tttattgatt aaaaagcatc atatcgatat gtcggaaaac 1665541 tggtttcaga aatacggcgc cggagttgtc ttctcggctc gttttatacc ggttgtcaga 1665601 catgccatat ccattccggc aggtattgcc agaatgcctt ttctcaaatt tgtggtactg 1665661 actgtgcttg ctatcattcc atggtctatc ctgtttgttt atttaggcat acagctagga 1665721 agccagtggg atgatgttga gaatatagca ggcacttata caacaccgat tatgatattg 1665781 gctgttgtcg tgatagccct ttattttgtg attaagaaac gtacagccat atttaaacga 1665841 tagctagcgg atatgcatag gggtgactga cgctccccta tgcatatttt tttacttgcg 1665901 atgttgattt gccagcttca gattctccgc taaaaatgcg acaaacactt catcccgcac 1665961 gagcgatgcg gcataatttc tcttaataaa ccattctgcc tcttcaaacg ctgcgaatgt 1666021 ttcgtcttgg gtttctccgt taatttgaat attccattcg ttgtctaaag ggaaaagaaa 1666081 aaatctcatt tgtgcgcgat tttcatataa tgatccattc gcagatccct ttagattata 1666141 gatgttacgg aaggcatccg gccgtacagg atcaatacgg aaagcttcag ctacaaacaa 1666201 ctcgtatact tcatcggtta ttgaacagcc ggacgctttt gcatgccctc cgccgccata 1666261 tcggccggcg atttctgaca catcgatgta atcatgaatg gtgcggagac tgactcgttt 1666321 tgaccccatg ctcaaaatcg caatgtaatc gaggtgcggg ttatctttcc ctagcctgtt 1666381 ccccagctct gaatggtacg attcagcgtg aacgatgcct acacagtgtt cgtgaacaaa 1666441 ggtttgtacc atttcccttt tctttctgcg gaggtagcgc tcgatttttt cgtcttctaa 1666501 atcaagcagt ttttcttcaa aatcatcgaa gaaaaattcg tcatgcgtgg aaaggcgctg 1666561 gatcattttt gcttcaaatt catcgattga cagcaaaaag aaaagatcat taagccgctt 1666621 cgcctgtttt tgatcgtacc gctcccactc ccatgtatcg tattggcgga cgagctctgt 1666681 gaattgatct aaggcgtttg tcggtttcat gaagccattt tcaatgagat agccatataa 1666741 aagcgatgtc gcggatgtga gccttccatc atcgtattcc acctggacaa atccccattc 1666801 atgctcattc aaatgaaggg ctgttttatg atggtcaatg agcttcactt tgccccctgc 1666861 atgaacatac tcattcaatc tctcttcgtt ttcttcattg acggcgagat cggtgatgaa 1666921 taacgcgtcc tgtctgttgc tctccttcgc tttttctaaa aagtactgca cctgtgcgtt 1666981 taagccgttg acagagttat accggatctc tacgtctttt ccgaacgcca attttgctac 1667041 gattccgcat cctactccgt ccaagtcgtt atgtgaatat aaatgataca taatgtaggc 1667101 ccctttttat gataaactga caattgccgc tagaggtgcg gcagccttta tttactattc 1667161 taaaaaacca agcgttttat gcaatggtaa ttagttgaca taatgttgtt attgtaaata 1667221 tataaaggag cgcttttttt gcgctcctaa gttcttgctt ttacaccgga taaaccggat 1667281 gctttcgatt ggtaaatgtc atttcctttg tcatgtatgc cttgagccgt ttggccagct 1667341 catcacgcag cgaattggct gggataacag catcaatgat catttctgaa gccagacggt 1667401 agatattgat gtcctctttg tattcctccc gtttgctgct gataaatgcg gctctctctt 1667461 cttctggcag ctcggcgatt tttttagcgt agacagcgtt tacagcggcc tcagggccca 1667521 tgacggcgat ttgggcggtt gggagcgcta gacagcaatc cggttcaaat gccggccctg 1667581 ccattgcata caaccccgcc ccgtaagctt ttcggacaat gacagagagt tttggaacag 1667641 ttgcctccga catcgcagaa atcattttcg ctccgtgtct gataatccca gcctgttcta 1667701 cttttgtgcc aatcataaaa ccggggatat cggctaagaa cagcaatggg atatgaaaag 1667761 cgtcacataa ggtaataaac ttagccgctt tgtctgctga atcgtggaat aagacgcctc 1667821 cttttacctt cggctggttt gcaacaatgc cgacaggctg tccgtggatt cgtgcgaggc 1667881 ccgtcaataa ttccggtgca aataaggctt tgatctcaaa aaatgagtct tcatctatga 1667941 cccgctcaat gagctcatgc atatcaaaag gtgcgttttg attttgcgga atgacgtcgg 1668001 caagcggagt ttcgaagtgt tttggcgggc gtttctcatg aatgggcgct ttttcttgaa 1668061 aatttgccgg aaagtaagac aaataagccc gcaccagctg tatggcttct tcttcagttt 1668121 ctgcaagaat atctccgcag ccggagattg agcaatgcat acgggcgcca cccatttctt 1668181 cgagagacac tttttctcca ataaccattt ccgccatcct tggcgaacct aaatacatgg 1668241 aggcgttacc gtctaccata acgacgatat cacagaaggc cggaatataa gcgcctcctg 1668301 ccgcagatgg tccgaaaagc agacagattt gcggaatgcg tcccgataat ttgacttgat 1668361 tgtaaaaaat tcttcctgca ccgcgtctcc ctggaaagac attgatttgg tcggtaattc 1668421 gggcgcctgc cgaatcgact aaataaatga gcggacagtt taatttttcg gcgatttctt 1668481 gaattctgat gattttttca actgtttttg ctccccatga ccccgctttc actgttgaat 1668541 cattcgccat gacgcaaacg gtttggccgc cgattttgcc gatagcggtt acaactccgt 1668601 cagcgggaag cccgtctgac atacattccg caaaaaaagc gtcttctagc tcaatgtcat 1668661 cgtcaaagag aagggaaagc cgctctctga caaagagctt gcctttttcc cgattgcttt 1668721 gatgatactt ttccgctccg ccttttcgaa tccgttcagc ccgttctgtt cgttcctttt 1668781 cataatccat cagcattgcc tcccttttat attcccttgt atacggcccg tcttttttct 1668841 tgaaaggcct gaagcccttc tctcctgtct tttgtcggga tggtttgttc atacgctttt 1668901 tgttcaatcg caaggcctgt agcaagatct gtctccaatc ctttattgat tgcaaattta 1668961 gcctgacgga cagcgatcgg tccgttggca gaaatggctg cggccagttc ctctgctttt 1669021 ggcataaggt cacaaggagc cgtgacatgc tctacaaggc cgatttcttt tgcttcgtgt 1669081 gcggtcacgc gtctgcctgt ataaatgaat tcttttgctt ttcctctgcc aatcagccgg 1669141 ggcagccttt gggtccctcc agcgcccggg ataatagcta accctgtttc cggaagtccc 1669201 agcacagctg cttcagttgc gattcgaagg tcgcatgcca atgccaattc tagtccgccg 1669261 cctaatgcgc ttccatttat cgcagctatg accggctgcg gcaaggcatc aagtaaagcc 1669321 gccgttcttt gaatgagaga tacactttcc agaacctgat cttctttcag ttttatccgt 1669381 tccttcaggt ctgcccctgc acaaaacgct ttttcaccgg tgcctgtgag gatgacgcaa 1669441 cggatgtttg agttaaattc aatttcctgg ataatcattt gcaggtttct aagcatttcc 1669501 gctgaaagag catttgctgc ctgaggcctg tttaaggtga tcaacgccat atgttcattt 1669561 ttaacagtaa aaagaataga atctcccatt gtatgcgtcc tcccttttat caagatgatt 1669621 taaacacctg taaatttctg ctcggcagcg gtttgcccat tttttcttca atccatttgg 1669681 ccgcagatag cagtttttct agctttacat ttgttttgat atccatctgt tcaagcatgt 1669741 acacgatatc ctcagttgcg gcgtttcctg atgaacctgg cgcatatggg catcccccaa 1669801 gcccgcctgc cgagccgtcg aacaccgtga tgcccatttg gagtgctgtg accatgttgg 1669861 ccagagcggt tcctctcgta tcatgaaaat gcagggcaat ttgattagcc gggaatcgtg 1669921 ccaaaagagc ttcaagtaca gtttccactt gggcgggatt agctgctcca atcgtatctc 1669981 caagcgacag ttcagaaatc ccaaattcaa atagagcttc tgaaaggcga atgacttgtt 1670041 caatggggac atctttttcg tacggacagc cgaaaacagt cgagaggtag gctcttgttg 1670101 tgaggtttgc tttttgtgcg tcgttgttta cttgtttgag tatatggagg gattcagaag 1670161 tggatttatt gatgtttttt ctgttgtgcg tctcgctggc ggacataaaa acgcaagcct 1670221 cgttaatgcc tccttcaagt gcattctcca gtcctctttg attcgggaca agtgccgcgt 1670281 acgttacccc tttttctcgg tcgatgcctt ttgctacatc gatagcatct cgaagcgccg 1670341 gaatccattt cgggtgaacg aaggatgtga tttcaatata cgacagccct gtccgggaaa 1670401 gctggttgat ccaggttatt ttatcctctg ttgcgatcca aacgggctcg ttttgtaagc 1670461 catcacgcgg gccgacttct ttgattgtca cttttttagg atatggcatg gtcttcctcc 1670521 aaattattga gtggaattgc tcagttcgag cagtacgtct ccttcattta caaagtcgcc 1670581 ttcctttttt ttgacttctt ttacgattcc gcttctatct gcaacgatcg ggatttccat 1670641 tttcatcgat tccaaaatgg ctacctcctg gcccttttcg atttggtcgc cggctttgac 1670701 gtggactttc cacaggtttc ctgccatttg tatgctaacc gtcatgacaa ctgcctcctt 1670761 tataggtgct gtttcaaaaa gtcagtcgtg acatcccctt ctttaaatgc ctttgttgcc 1670821 gcagcctgta tgaggagcgg aaggtttgtt ttgattccct ctacacgata gtcgcgaagc 1670881 gctgtctcta gtttttcaat tgcttctgtt ctggtttggc ctttgacaat catcttagcg 1670941 atcatcgggt cataaaaagg ggtaacggtg ctgtcttttg ctaccgcaca ttcgtgtctg 1671001 actccttttt ggtcaggaag tgaaaacgca gtgatcgtac ctggtgacgg gaagaaggtc 1671061 ttgggatctt ccgcgtatat tcgaacctct atcgcatgcc cgttccgttg gatgtctttt 1671121 tgggagaatg tgagtgtatg gcccgcagca atccgcagct gctgctcaac taagtccagg 1671181 cctgttattt cttcagtcac ggggtgttca acttgcagtc tcgtattcat ttcgaggaaa 1671241 taaaaatttt gtttctggtc aactataaat tcgatggtgc ctgcgttcgt atagccgatt 1671301 gccttcgctg cttttaccgc tgtttgaccg atcttcattc ttagttcatc gtctacaaat 1671361 ggagacggtg cttcttcaat gactttttgg tggcgcctct gaacagagca atcacgttca 1671421 aacagatgta ctgtatggcc gtgttgatcg gccaaaagct gaacctcgat gtggcgcgca 1671481 tgttcaataa ctttttctat atacatagac ccgtcaccga aaaaatctgc tgcgcgcttt 1671541 ttgtttccct cgtacgcttt ttttaatgct tcttcatttt caacacgctg cattccgatg 1671601 ccgcctccgc ccgctgaagc tttcagcatg acaggatagc cgatttgact tgcggtgcgg 1671661 caggctgcct ctatatctcc gagggattca gaaacgcccg gcaccacagg gacacctgca 1671721 gcctccattg cttttcgcgc ttcaattttg ctgcccatct ttgcgatgat atcaggggaa 1671781 ggtccgataa acacgatgtt ttcttgcttg cagcgttcag cgaaccggct gttttctgat 1671841 aacaatccat atcccgggtg gatcgcgtcg gcttttgctt ttttcgccgt ctttatgatt 1671901 ctctctatat ttaaataact ttcactgact ctcgattccc cgatcaaata tgcctctgta 1671961 gcggcttttg tatggggcgc gtccttgtct gcttctgaat aaacagcgac cgttttaatg 1672021 ccgagacggc tgcatgttcg gataattctc attgcaattt caccgcggtt ggcgatcagt 1672081 acttttgtaa acatgatttc acctcattga cttgatgata agttgaacat ttcaatcgtt 1672141 ttttctcgca gtttatattt ttgaattttg cctgaggccg tcatcggata gtcatccgta 1672201 aaaataacat aacgcggaat tttgtggcgg gcgattttcc ctttgcaata ggctttaagc 1672261 tcatcaggtg aaacgctttt accgtctttc agtttaatcc aggctgcagc ttcctccccg 1672321 aatttggcgt caggcacacc aaccacctgt acatctaaaa cagcgggatg ctggtataaa 1672381 aattcttcaa tttcccgcgg ataaatgttc tcgccgcctc tgatgagcat atcttttaat 1672441 cttccggtga tgcggcagta cccgtcttca tccatgacag caagatctcc ggtaaacagc 1672501 catccgtcat gattgattgc ttttctggtc gcatctttgt ctttataata gcctttcatg 1672561 acgtgatagc cacgggtgca cagttctccc tgcatgcctc tttgaacttc ttgacatgtc 1672621 ccgggttcta caattttcac ctcagtatgt ggcagggcac ggccggttgt ttcgactctt 1672681 cttatgaagg aatcatttgc tctcgtttgt gtaatgactg gcgaggcttc ggtttgtcca 1672741 taggcgatcg taatgtcttt catgcccatc ctttcaatca cagctttcat cacttcactt 1672801 ggacagggag agccggccat gattcctgtt cggagcgtcg atagatcata tgcatcaaaa 1672861 tccggatgat gcagctcggc gataaacatg gtaggcacac catggagcac tgtgcatttc 1672921 tctttttcta ccgttttaag gacggtaacg ggatcaaatt cttgcacggg tatcatggct 1672981 gccccgacgg atacacatgc caaaacccca aggacgcatc caaagcagtg aaaaaacgga 1673041 acagggatgc acatgcggtc ttgagaggtt aaagccatac attcagcgat attagcagcg 1673101 ttattgatga cattgaaatg ggtcagcatc acgccttttg gaaaccctgt cgttcctgat 1673161 gtgtattgca tattaatcac attgtcttta tccaggctgt tcattctctc ttcaagctca 1673221 gcatctgtca ctgttttcgc caatatctct gtatcgtccc aatgatacat gccagacaat 1673281 cgtttattgc caatatagat cagcgttttt aaaaagggat agcgttcaga tttcagttgg 1673341 ccgggctttg cttcttgcag ttctggaatt aaactgttca cgatgtctgg ataagaagtg 1673401 cccctgtatg aatccatgat aataagcgcc gcggcatccg attgctttaa caagtaatca 1673461 agctcatgtg cttgataatt ggtattgacg gtcacgagca cggctccgat cttcgcagtt 1673521 gcgaactgga cggcaagcca ttcagagata ttagaagccc atatggcgac gtggtctcct 1673581 tttccaatcc ccatccgcat gagaccttta gcggtttgac ggcacagact gtcaaattga 1673641 gcgtacgtat agcggatatt tcggtctgga tacacaacag catctcgatc gggatacgca 1673701 tcagctgttt gttccagcag cctgccgatt gtggaatgga tgagttcagc cattcattgt 1673761 tcctcctttc ttaatgatag gaaagcgttt acatttttat tttaaaagct gtctggcgat 1673821 cacgagacgc tgaatttcag atgtgccttc accgatttcc attaattttg cgtcccgcag 1673881 catccgttcc accccatact ctttcatata gcctgaacct ccatggattt gaatggcttg 1673941 attgcaagct cttgtcgcca tttcagatgc gaatagcttg gcgtacgccg cttctttggt 1674001 gaacgggcgg ttatgatctt tcagccaggc ggcttttaac accatttgcc gtgccagatc 1674061 aatttccatc gccatgtcag caagcttaaa ttgaatcgct tgaaaggaag aaatcggctg 1674121 tccaaactgc tttcgctctt tcgcatatgc caatgatgcg tcaagggccg cttgggcaat 1674181 gccgactgca agagcagcga tggagattcg accaccatcc agcgtatata gaaactgttt 1674241 aaaccctttt gttggatcgc caagtaagtt ggccgcaggc actcttacat cttcaagcaa 1674301 gatttccgct gtattcgaac cgcggacgcc cattttatcg tacgggctcg taatcgtaag 1674361 tcctggtgtg tcagttggca cgattaatgc ggagatgatg ttttttccgt ctttgttttt 1674421 gcctgttacg gcggttacaa taactgtgcg tgcgtagctt gcattagtga tccagcactt 1674481 ttcgccgttg attacatact cgtcaccatt tgaaatcgct tttgtttgag tgcctcctgc 1674541 atctgagccg gcatttggct ccgtcaggcc gaatgatccg agtgctgtgc ctgaagccag 1674601 cggcgtcaaa tgcgtctgtt tttgctcttc tgttccgaag tagtaaagag ggcttgcgcc 1674661 tagcgagacc gctgcagcat agcttaatcc agtactgccg caggctttgc cgacttcttc 1674721 aaccgctaag gcatatgaaa tcgtatcacc gccagatccg ccgtattctt ctggaaatgg 1674781 aatacccatc agaccgagtt cacccatttt tttaaatgtt tgcatcggga actcgcctgt 1674841 ttgatctaca tgttcagcgt gaggagcaat ttcttttttc gcaaaatctt ttaccatttc 1674901 acgcaccatt tgttgttctt ttgtcagctc aaaattcaca tcgtttcctc cttcacatct 1674961 ttgtaacatc ctattaggcg agttctataa tcattccctg acaagaaaag tctgaaaatt 1675021 aaaactgaat cattttttat gtgataatat cagcgggatg agcaaataca tgcagtaggc 1675081 gcataccatc catatcgtaa acgcaataac ttggcccttt gataaagccg ggaagatgag 1675141 gggaagattc caaagggaaa tcgtatccat caataaaccg accgctgatc cccatatacc 1675201 tagcttgatc accgcgaact gtgattgatc gagtttttga tagagaaaga acacaaggca 1675261 taaaacaaga gcagtgcccg ctcccaagag aagaaagttc ggcaaaaagg cttcttcagc 1675321 cggatcagtc aacacagcat ctccgaacag cacaaaaaat aatgtggcac ctaaccagac 1675381 tagaaatgaa aacgtaaaac acgtcctgta cgtgtttctc ttcgatttta tttttattta 1675441 gtactagttt ctcagattcc aataatggta aatgtccaaa caccgcctcc atattcatgt 1675501 gaatctcacc tttgtttttt aaaaaattca gcggtttacc atcgtttcct gtcccaaaat 1675561 cactttttaa aaaaagacga cttagaaagc cgtccttctc atttcttatt ttgttgttcg 1675621 tttggaagct ttgctttcgt tatgaagccg gtctgctgaa gtgacataat acgtatattt 1675681 cttgttggga tctgccgtgt tatctaagaa ggtttgctgc tcatgtgttt ttctttgcgt 1675741 tgccagcaat gttctctgct ttttcccttc ggctctgtat atcgcataat aggctgtttc 1675801 tttcgttttt tgatttgatg ggtgatcttt aatctgcaga agattgccgt ttttgtcttc 1675861 ggtgactttc gtaagcttcg gtttttttgg ggcggtattg tcaagccaag gcatttgcgg 1675921 aaccagtgcc ggcttgctgt aaagatcggt gctgagactg tctttgatgc caagcggatt 1675981 tttgttgagg tccttgaggc tgaaatgcat gcttcctttc accagttcaa gctggcggtt 1676041 caaagtgatt tgccgcacat attcctcagg atcggaccaa ggcggatcaa aattgttatt 1676101 gattttatat gctgcctggc caatatataa gtgaacaggc ctatttttga cttcattgct 1676161 ccaccaatca gccagcacgt cgtaagccgc tgcgttaaag ccgatactcc aataaatttg 1676221 cggagcaata taatcgatgt cgccttcttg gatccaatgc cttgtgtctg catatagatc 1676281 gtcataattt ctgacgcctg cttttgtatt cgatccggtc gggtcatctg cggcgtttct 1676341 ccatactcca aagggactga tgccgaattt gacatacggt tttgcagctt taattgtttg 1676401 gttgatttgt ttgacaagct ggttcacatt gtcccgccgc cagtcatcga tattagaaaa 1676461 agcgtctttt ccgtattgtt cgtactgtgc ttgatcagga aattcctgtc ccgctatttt 1676521 ataagggtaa aaataatcat ccatatgaac agcatcgata tcataatgtt ttacgacttc 1676581 ttcaatgcct ttgacgataa aatctctcgc ttctggaatg cctggatgat aatacagctg 1676641 gtttccatag gcggcaaccc aatctggatg ttttcttgcc gggtgatcct cagacaattt 1676701 attaagatct gtatgattca ttgtaatacg gtaaggatta aaccacgcgt gaaattccaa 1676761 atttcgttta tgggtttctt caatcataaa tgcaagagga tcatagccgg ggtccttccc 1676821 ttggacaccg gttaagtatt ccgaccaagg cccgtaagct gacggataaa aggcatcagc 1676881 cgtcggttta atctgaacga taacggcatt cattcccatt ttttgcacat cgtccagcag 1676941 tttgatatac tcctgttttt gctctttcac agataaccct tttttggacg gccaatcaat 1677001 atttaatacg gaagcaatcc atacggctct cagctccctg tcagactgcg cattggccat 1677061 aaacggaacg gaaatgacaa acgttccgat gatcaagctg acaaggaaac ggacaatcga 1677121 cttttggcaa accttcattc tgtttcttct cccccattac atcactttca ctattcgcta 1677181 ttacggtatt cccgggctat aaaagggtga ttaacagaat gtctatctca ctaaataaac 1677241 gaaaaaagtc ctaaagcatg ttgtgaaccg cttttaggac tttttatcat tcatcatggt 1677301 ttgcagactt tttaacacat caataagttt tacgccgaca ccgacagccg tttcaaggat 1677361 cgcttgtgct ccggcaatgg ctaaaataaa gatcagcggt attgcaatac gaggcaaaaa 1677421 aagatagcca agtccgatca agatggcaca ccaaacaccg gcacaccagt agcaattgag 1677481 catgtatcca aagttagaag ccggcacgct tttttcatct acatgcccgt tttgatcaac 1677541 aatccttttc tttttcataa aaggttttcg gataaattct gtgattttgt caaatacaat 1677601 caaatgtgtc agcctgtaac tggctagaat cagcatgata aaagttagaa aagaaagacg 1677661 gtccattgag aagcctccaa gaaaaaggat gatgttatca ttcccaagtg tcccttatcc 1677721 attcttgata caaaaagaaa gacggacaga gaatggcctc tgtccgctaa tccgagctca 1677781 ttccctccag ttctcataat aagaggataa gaaaatgtag aaaaaagcag aaaaatgaca 1677841 ataaaagaaa ttatatgact atataatcca tatatgcact atattaacgg atatttttta 1677901 aagtacaata aaaaacatta aatttttata acattttttt tgaatatagt attatttctt 1677961 tatttttcgt ttcttttttt atcaaatttc cggatataaa gtgataaaag tattgtttta 1678021 cataaggtct tatacactac tttttaatcg gactaatttt cttttgtgca tcattcttct 1678081 aattgttgga aggttcgaca aagcgttatt acagacataa aaaaacctgt tttctcttgg 1678141 aaaacaggtc tcccgctatt attgatttgc caaaatgaca gcgatttgat cctcaatatc 1678201 ttttccatcc tcttcatcaa tcaatccatt tagaagaata gagaaaacaa gtttttttcc 1678261 gctctttgtt tctgcgtacc ccgatagaga gcttaccgta ctgagcgatc cggtttttgc 1678321 tcttactttt ccttgtgcag gagtgccttt catgcggttt ctcagcgttc cgcccaccat 1678381 tctgtcagga ttccccgcaa caggtaaaga atttagataa gccgagaacc aactctgatc 1678441 ctgaatgtca tataacagct gtgaaagttg atctgaggat acagcatcaa tatgtgagat 1678501 tcctgatccg tcccttaaga cgagtgattt agaatcaaca ccaaattccg gaagcgtact 1678561 gtttaacact tcgagcccct tttcccagct cccttctcct tttttcactt tccccatctc 1678621 ttttacgagc acttcggcat gtccgttatt acttaatttc atgaacggca caaaaagttt 1678681 cgataaaggc attgagcgat gagagagcag cacatctgaa gaactaggtg cttcacccgt 1678741 cttgatgtcc cctttcacag taataccttg tttttttagt gactgcttaa ataaatctaa 1678801 ggcatatccg gcaggctccc agacagaaat ccattccttt gtcttgtttg cgtcaaccgg 1678861 tacgctccct tcaattgtaa tcgtgtttgt tccatgctct ctttcgattg tgaggtcttt 1678921 ctctgaaccg gcagcagtcg ttttagcatc gttctttatc gttatataat cggttttcgg 1678981 agagacagac acggcaggct cttccccttc tttttgattt ggggtgacct caacaatcac 1679041 agtgcctgca tcatagtctt cgtttggaga cgctgttaga gcggagattg gcgcgccata 1679101 atatgtgtat tcatcgctcc aaggcatatc aggtgataat cgcatgtcat catgccacgt 1679161 atcatcaccg atcagattgc ctttaattac ttttacgccg gaatgtttca atatctcagc 1679221 cattttgtca aaatcagatg gtaaaagtgt cggatcgcct ttccctttca aataaaggtt 1679281 accattcagc tttttccctt tcagtgttcc atccgtccgg acctcggttg taaaagaata 1679341 gttctcgcca aggacagaaa gtgccgcggc cgctgtcaaa agctttagag aagaggcagg 1679401 cctcattcgg gtgtctcctg aatgttcata tagaacagca cctgtttccg cagagcgaac 1679461 ggtgatgccg gccattgcgc cttcgagggc aggatgatca gctaaaatct tatcgatctg 1679521 cccggaaagt gcatcttgtt tttcagcggc aagcgcagcc tgatgcatat aaggcaccga 1679581 agcaacgacg aaaagcagta aaacagcaac ataaagcttt atgctttttt tcattaattt 1679641 ccccgcctct ctgcgcttca tcattggcta ttgatgattc agttcaatgg tgatactgct 1679701 tttagctgtc gtttcttctc ccggctccag cacttgtaaa ccagtgagtg acgaaggtaa 1679761 atcaagattc actgcgtttg tcacccatgt gtaaggctca gggcataaat acccttgttt 1679821 tccgtccgca ttgtatacaa cccaatgttt aaactgttca tctgccttat aaataatgct 1679881 gatatgtgca tgctgatgat aaatgactgc ctggttttct ccgcccctct tctgataaga 1679941 agataaaaag acatcatcca gctgcttgtg gcgcaaatcc attccttcat gcaaagcttc 1680001 tttatacggg acatccatca gcttcccggt cggcagcagg cgttcatcca actcccattg 1680061 ctgatctgct gtcagggaga ataacgagct ttctgccgga aatataaatg tagtatgata 1680121 accaattccc caaggaaacg cttcctttcc tttgttcatg accgtcgcat gtttaaatag 1680181 ggtattctcc ttgatcgtgt atgtcatccg aacgacggca tgatgaggaa attgcttctg 1680241 cacatgggga agctcagaaa gatcaatttc tgtttcaaca atcactcctt catcagtttg 1680301 cttcgtggtc acgacattcc acttttcatg gtaaagaaac ccgtgaagat ggttgtgttt 1680361 atccttctcg ttgatatcaa aatgatacgt tctgccccgg aaactgaatg taccgtcact 1680421 tatgcggtta ggcgggaaca ggattggaat gccatacaat gttggtgtgt cgtgaaaact 1680481 ttctgctgtt tccggttcac gcaaaagctg gacatttgtt gttttgtcca cgagagaaat 1680541 gacgttgctc ccccactcag ggacaacaat catttctaga tgttcgttgc ccgctttgat 1680601 ggccggcgtt cccaaatacg tgattttctc aataaagttt gccatgttta ctcaacctct 1680661 ccttgattca ttgctagtat aagaattcaa tgtactgtac catatttcct ccattttata 1680721 ttttccccta tcaaataaaa aaacaccgtt caaacttatg aacggtgtga ttcggaggct 1680781 attggatgag acgtgtgatt tgtttctttt tccagacgaa ttgataatac ccataaatca 1680841 acagcaagct gacggcaaac gcagctggat aaccaaccca gacgccgagt atttcaagct 1680901 ttgtatagtg agaaaggacg aaagcgacag gcacctctac tccccagatt gcaaaaatac 1680961 tgatgacggt cggccataaa actgttccgc ttgcccgcat cgttgcagaa ataatttggg 1681021 catttccaaa cagcaaatag ctccacagtg taatcatcaa aagacggtgc gcaatgtaaa 1681081 gcgtctcttg ctcggttaaa aataacgata aaatctgatg tgaaaaaaca tagatcagaa 1681141 tgatcagtac gccgccaatg atataattca gccaaatccc aacgcgaatg acctgcttta 1681201 agcggtcaaa ctcgtttgct ccgatcgatt gcgcagcgaa aatagaaacc gcaataccaa 1681261 ggctgacggc cggcatctgt acatagctgg ccacctggtt gaccactccg tatgcagctg 1681321 ttgcattaga gccgtaatga ttgacgaatg aaataaccgc tatctctgat aatgagacaa 1681381 gaatcatatt gatgcttgct gggaccccaa gacgcagcag gagaaccagc agttccttat 1681441 ccattttcaa ataacgacgc actgttttat caaattgcag cgggtgtttt cgctttcgta 1681501 aatacaccat taacacgaga aaagtcgcaa tcgtggaaat gacagttgca tatgccgagc 1681561 cgtatatgcc cagtttcgga aaaccaaaca tgccaaggat taaaacaggc aaaagcgcga 1681621 tgttgatgac cgtgctcaca atcagcgtat aaaacggtgt cttggaatct cctgttccgc 1681681 gcaaaaaggt agtatatgca aaatataaaa acataaacgg catagcataa aataaaatac 1681741 gtgcatagtt agcgctgaca tgaatgacat tttcaggtgt tcccattaaa cgaaggatat 1681801 ccagggtgaa aatactgccg ataacggcta acacaacgcc taataaaaat gtaaacgtga 1681861 gtgtcgtccc gacaacagcc tttagccgtt cctcattttt cgctccgtaa gcttgtccta 1681921 tcagaatcga acttcctgaa ccgatcccaa tcgtaaatga gattaaaaga aaaaataacg 1681981 ggaaaaagga tgatacagct gccactgcat caacaccgag ccatctgcct acagccatca 1682041 tcccgactag ctggccgact gattgcagca cattgctcag cagaagcggc actaaaaaga 1682101 gtgacatcga ccgccaaact gatggtttgc ttttcttttg agttacaaga ggttcttgtg 1682161 atgtttccat attaaaggac tcctttattt gaaatcgttt ttaaacatgc cctcattttt 1682221 tgacaaaaac aggatatgta acatgttatt attcatcact gcacttatga aacccttccc 1682281 gattcttcta attttacaca tctttttagc ttatgaagaa taaactagca agtaatggcg 1682341 tattttttgt gagtaaaaga ataaaaaata atttatgcaa aagtattgta atctatccgt 1682401 aattattgta acatttgtaa cataagagaa agagattttg aaggagagag cgataatgaa 1682461 aaaatgtctt ctatttctaa caaccattgc acttattctg tcattaagca caaatgcatt 1682521 tgcgaaaaat acatcaggcg atttatcaca aaaacaagca ttacagttgg cattatccgc 1682581 tagagaacat ttttggaaca ccatgagcgg ccacaatccg aaggtgaaaa aagcagtttg 1682641 cccatcaggc acattcgagt atcaaaatct tcaatatgta tacatgtgca gtgatctagg 1682701 cactaaagca aaagcggtga attatttaac tcctattttt acaaaaacag caatcgaaaa 1682761 aggctttaaa gattatcatt tcactgtttc aaaaggaaaa cttgctgttc caatcggtga 1682821 cggagacaat cttttgaatt ggaaaaaatc aactgctaaa ctgatctcta aaaaaggcag 1682881 cacaatcaca tacgaattta ctgtccctac attagacgga tccccttctg caaaacggaa 1682941 agtgacattt gtgaaagaaa ataaaaaatg gaaagtcaat caatttgacg cagttatata 1683001 agaaaaacgc ccggtataag cgggcgtttt ttatttggtt tgcataaaga aagacaacag 1683061 gcgaaaagtg cctgttgtct ttttgtgaat ataacgctct aggagagatt cgaactcccg 1683121 acctgcagtt taggaaactg ctgcactatc cgctgtgcta ctagagcttt tggtatttat 1683181 atagtagctc tgatgatcaa tattttcaag cgatttgtat taaagccctc caaaaacctt 1683241 atatgcggct cttgtcgtat cttcatcaat accgatatac cgcattgtaa ttgatggtga 1683301 tgaatgattc agtattctct gcagctcggc gatgtctttc gttcgctgat aaaaatgata 1683361 gccaaacgtt ttccggagtg tatgcgtccc tatctcctca agtccgcacg ctgcagcggc 1683421 ctctcttaaa attctgtagg cctgaatgcg ggaaatcggc ttcctggtcc gcactgattt 1683481 aaaaagatat tcgttttcct tcatgtcttt cgtatactcg tatatttcct gtttcagcga 1683541 ttctaaaata agaatctttc ttttcttttt cgttttgctt tcagtcgccc ataaatgatc 1683601 tttattttga acgtccttca cttgcagcgg cagaatatca gaaatacgga gcgcgctgtt 1683661 gatgccgaaa ataaacagaa aataatcccg cttgtttttg ttaagcaaat actgtttgac 1683721 ttcttggatt ttctctagac tgcgaatcgg ctgtacaata tgcatcaaaa aactccttaa 1683781 aaaccgttat gtaacatttt gaggtctatg ttactattat agctgaaaaa cgttgaatgt 1683841 caaagtgcgg cggcgtttat gtaacataat atacatagtg ttacataagc ttttaaaaaa 1683901 gcttcttcca accttcaccc tataaaataa gctttaaagc ctcttataaa gcttttaacc 1683961 tcttggatac ttatccccct actaatcatc aaaaaacctc ttaaaatgaa atctgacact 1684021 cccaattttc tggagcttcc gcaaaaatat acaaaaaaag acacaatttc aaattgtgtc 1684081 ctaatcctca tcctttacat caatatcttc cgggatcggt tcatttaata tttcctgcac 1684141 aagtgctttg taattctcca gctgttcgag atgcgttttg aactgttcct tataaatcaa 1684201 aaattgctcc ccgtcatgaa cggctctgat tttcccttcg agcaccaagc ttttaatata 1684261 atcctctgaa agatttgtat attctgctgt ttcttcaatc gttaaataca tatagcagtc 1684321 ccttcttaat ccgtatgctg attctaatat agcacatggc tcatatcaat ataatcaatt 1684381 ctgcacagaa aaacggcatt atgcactata taatatacca tttgtcactt gtgaaaacgc 1684441 tgtaattttt ttacgctaag attgtaacaa tacagcttca tataggaggg agaacatgaa 1684501 aagaacgtgg aacgtctgtt taacagctct gcttagtgtt ctgttagtcg ctggaagtgt 1684561 cccttttcac gcggaagcta aaaaaccgcc caaaagctac gatgagtaca aacaagtaga 1684621 tgttggaaaa gacggcatgg ttgcgaccgc acatcctctt gcttctgaaa tcggtgctga 1684681 tgtgctgaaa aaaggaggaa atgctattga cgcagcggtt gccattcaat ttgcactcaa 1684741 tgtaacagag ccgatgatgt caggtattgg cggcggcggt tttatgatgg tgtatgacgg 1684801 aaaaacgaag gatacaacga taatcgacag ccgtgagcgt gctccagcag gcgcaactcc 1684861 tgatatgttt ctggacgaaa acggcaaagc aattcctttc tctgaacgtg taacaaaagg 1684921 tactgccgtt ggtgttccag gcactctgaa agggctggaa gaagccttgg ataaatgggg 1684981 aacccgttcg atgaagcaat taattacccc ttctattaaa ctcgctgaaa aaggctttcc 1685041 gattgattcg gtgttggcag aggccatttc tgattatcag gaaaagcttt cacggactgc 1685101 cgcaaaagat gtatttttac caaatggcga accgcttaaa gaaggagata cccttattca 1685161 aaaggatttg gctaaaacat ttaagcttat tcgctccaaa ggcactgacg ctttttataa 1685221 aggaaaattc gccaagacgc tttctgacac tgtccaggat ttcggcggat caatgacaga 1685281 aaaagattta gaaaattacg acattacaat tgatgaaccg atttggggag attatcaagg 1685341 ctatcaaatc gctactactc ctcctccaag ctccggcggt attttcttat tgcaaatgct 1685401 gaaaatcctt gatcatttta acctttcaca atacgatgtc cgctcatggg aaaaatatca 1685461 gctgcttgct gaaacgatgc atttgtcata tgccgaccgt gcgtcttacg caggtgatcc 1685521 cgaatttgta aatgttcctc tcaaaggcct gcttcacccc gattatatta aagaacgcca 1685581 gcaattaatc aacctagatc aagtgaataa aaaaccgaaa gccggtgacc cttggaaata 1685641 ccaagaagga tcagcaaact ataaacaagt tgaacagccg aaagacaaag tagaaggcca 1685701 aacaacccac tttacagttg ctgaccgttg gggaaatgtt gtttcttata caacaacaat 1685761 cgaacagcta ttcggaacgg gtattatggt ccctgattac ggtgttattt taaacaatga 1685821 attaacggat tttgatgcga taccaggcgg agctaacgaa gtacagccaa acaaacggcc 1685881 tttaagcagc atgaccccga cgattttatt taaggatgac aagcctgtcc tcacggttgg 1685941 atctcctggc ggggccacaa ttatttcatc cgttttgcaa accattctct accacattga 1686001 atatggtatg gaattaaaag cagctgttga agagccgaga atttacacaa acagcatgag 1686061 ctcttaccgt tacgaagacg gagttcctaa agatgtcctc agcaagctaa acggcatggg 1686121 ccacaaattc ggcacaagtc cggtggatat cggaaacgtg caaagtatat cgatcgacca 1686181 tgaaaacggc acctttaaag gtgtagctga ttcaagcaga aacggcgcgg cgatcggcat 1686241 taatttaaaa cgtaaataaa taaaaaactg tactcgcttc aaatgagtac agttttttca 1686301 tgcagatctt taaaataaaa actgacaaac gtctttattc tgctaatgca cgtctatctt 1686361 catcttttca tttcgtttat ctcatcaaga aatgtctgaa acgcactcgt aataaaaaag 1686421 tctttcctgt atataaagac gatctctaag tcttgatatg atggtggcag ctgatgaatc 1686481 catacatttg tacgatgctc ggagccgtca acagcggact ttgggagcag cgccgtaccc 1686541 atcccggcgg aaacaccttt tataatagcc tccaatgtgc caaactctat gattttttga 1686601 ttgtgtatgc ctgcttcctc tagtaatctt ttgaccctgt cacgatgaga acagccagcc 1686661 ccaaaaaaga gcatcggctg ctgaagcatg tcttctgccg tcccttctcg tgatgaaatc 1686721 aaaactaatt catcatggga gacatggagt tgtctaactg cagcgtgttc aaccggccca 1686781 tatacaaaag cgccatcaac tttatgatca agaacctgtt gaatcaaatg atgcgtatca 1686841 gctgtgttca ctgataaatc cacttcagga aaacgcctga ggaaggatgc tgcatgctca 1686901 ggcagatgcg ttaccgccat tgtttccagt gatccgatcc gcaaaggccc ttttggttgc 1686961 ctgctcattc gggtcgattt ttcagcttgg tctaacagcg ataatacttg atctgcatat 1687021 tgtaaaagat tttctcctgc agcagtcagc ttcattcccc gattcgttcg atgaaaaagc 1687081 ctgatattca aatcttcctc aaggttatgc actctggctg tcacattcga ctgaacataa 1687141 ttcagcattt gggctgcttt cgttatgctt ccttcgcgag caacagcctg aaaaatcttt 1687201 aaatctccgc tttccacgcg ctctcacctg cttgctatga tgaaaagtga tattggctat 1687261 catatttgtt cattttactc gaagaaaacc gctatgtaaa atatgtaaag atatgaaaat 1687321 acaattaatg aggaggcaga cagcatgaaa gctgtaattc acaacggaaa agccggtctt 1687381 ctggggttat cagttcagga cgttccatca acaaagcctg gatacggaga ggtaaaggtt 1687441 aaattaaaat ctgcaggcct gaatcatcgt gacttgtttc ttatgaaaaa caaatctgaa 1687501 caagatcctc acatgatact gggttctgac ggcgcgggta tcatcgaaga gattggtgaa 1687561 ggcgtgaaaa atgttactgt tcagacagaa gtagtcattt tcccgacatt gaactgggat 1687621 ttgacagaaa atgttccacc tgtacctgag attctgggag gtccttcgga cggaacactt 1687681 gctgaatatg tgatcattcc ttcacaaaat gcaatcaaaa aacctgctta tttatcttgg 1687741 gaagaagcgg gcgttttacc tttatccgct ttaactgcat atcgggctct gtttacaaag 1687801 gggcaattaa aaaaaggcga gcatctattg atacccggca tcggcagcgg tgtagcaacc 1687861 tacgctttat ttatggctaa ggcgattggg gcaacagtaa gcgtgacctc ccgcagtgag 1687921 gagaaaagaa aaaaggcgct gaaattaggt gctgattacg catttgacag ctacagcaat 1687981 tgggatgagc agttgcaggg aaaaaagata gatgttgttc ttgacagcat aggacctgcc 1688041 ctcttttcgg aatacttccg ccatgtaaaa ccaaatggcc gtattgtcag ctttggggca 1688101 agctcagggg ataatctcag ttttccggtg cgttctttat tctttcctca ggtcaatgtt 1688161 ttgggaacct cgatgggaag cggtgaggaa tttcaagcta tgctcgcttt cattgacaaa 1688221 cataagctgc ggcctgtaat tgaccggata tatcctttag aaaaagcatg tgaagcatat 1688281 aaaagaatgc aggaaggcag acagtttgga aacatcggga tcgtaatgga ataaaaaaag 1688341 aaaccggctg gcagccagac cggtttctct tatatgataa tcccctttat ttacggaaga 1688401 actgaactcc ccatcaaata tcgatccact tcacgcgcca cttcacggcc ttcattaatc 1688461 gcccatacga ttaagctttg ccctcttctt gcatcccctg cggcgaatac accatcgata 1688521 tttgtttgat aatccccata tgctgcactg attttgttat ttactgaatt aacaccgaac 1688581 tgtttcaaca gcggctgttc tgtgccttca aagccgatag cgataaagac aagctgagca 1688641 ggccatactt tttccgttcc aggcagctcg cggaactcgt attttccatg ctcatttttc 1688701 actttttcca tttggatggt atgaagctct ttcagctttc cgtttttatc cgcgaccatt 1688761 tttgtcgttt gaatggagta ttctctcgga tctcttccga attttgcttc tgcttcctcg 1688821 tatgcatatt caagcgtaaa gacgtgtggc tgttcaggcc acatattgtc attcgtgcgg 1688881 gctggcggaa gtttcgggtg tttgccgaat tggtgcacgc ttttggcttt ttgacgcaga 1688941 gcggtagcca cacagtcagc tcctgtatct ccgcctccga ttacgatgac atctttccct 1689001 ttggcatcaa tgaattgctt gtctttaaaa ttagaatcta aatagctttt tgttgcaagt 1689061 gtgaggtagt ccattgcgta atggactcct tttgagtcgc gtccttcgat taagaggtcc 1689121 cgctgttttt gagcgcctgt gcataagatc acagcatcaa attgctcctt tagctcatca 1689181 gctgtaatgt caacaccgat ttctgtgttc gtgacaaaat caattccctc ttgcgtcagc 1689241 aatttaattc ggcgttctac aatgcccttc tcaagcttca tgtttggaat gccgtatgtt 1689301 aaaaggccgc ccgctctgtc tgctcgttca aaaacagtga cggaatgtcc cgcttgattc 1689361 agctggtcag cactcgccag tccggctggg cctgacccga cgatggccac ttttttgcct 1689421 gttcgttttt ttggaattct aggttgaatc cagccgttct caaatccttt atcgataatg 1689481 gtccgctcga tgtttttaat tgatacggcc ggatctgaaa tcgctaaagt gcatgatcct 1689541 tcacaaggag cggggcatac ccgccctgtg aattcaggaa agttgtttgt tttcaacaga 1689601 cgttccaatg cttccttcca tctgccccgg tagacaagat cattccattc aggaattaag 1689661 ttgtaaatcg gacagccgga tgtaaatccg ttaatgtccg caccgatctg gcaaaacggt 1689721 gtaccgcaat ccatacaccg cgccccttgc cgtttcgatg cttcttctga aaaaggagca 1689781 gaatattctt tccaatcctt taagcgagtg agagggtccc gctccgcagg tttttctcgt 1689841 ttgatctcca taaatccagt tggtttcccc atgttcctct ccccttcctt actgtactac 1689901 cgcttgtttt tgtcccgatg ctgctgtatt ctgctttggc ttcgtgttgg cctcaaaagc 1689961 gaacatgatg gcttcttcat ctgataaacc tgcagctttt tgctcttcga tgcttgcgag 1690021 catttgttta tagtttttcg gaatgacttt gacgaatttt ttcacactgt cttcccattg 1690081 atctagcaga tcttctgctt tttggctgtt tgtatacgca gtatgtcttt caagcattgc 1690141 tttgatttgc tggatttctt tctcatcctc taatgattca aataaaatca tctcaaggtt 1690201 gcatttgcgt ttaaacgctt tgacatcttc ggtcagtaca taagcgattc cgccggacat 1690261 acctgccgca aagtttttgc ctacatcacc gagaacgaca acgctgccgc cagtcatgta 1690321 ttcacagccg tggtcgccga tgccttctac aactacgttc acaccgctgt ttcgaacggc 1690381 aaagcgttca ccagcacgcc cgttaatata tgcttctccg cttgtcgcac cgtaaaaagc 1690441 cacgttgccg ataatgacat tgtcatccga agcagagttg aatccttctg atgacttgac 1690501 gatgattttt ccgccagaaa gcccttttcc gacgtaatca tttgagtctc cgtccaaata 1690561 aagcgtcatc cctttaggaa cgaaagctcc aaagctttgg ccggctgatc cggtaaagtg 1690621 cagcttgatt gtatcttcag gaagaccttc ttctccgtaa cgctttgaga tttcactgcc 1690681 ggttatcgtt ccggctacac gatttgtatt attgatttca atcgaaatat cagcttcttt 1690741 tccagattcg atggcttctt gtacggccgg gagaattgtt gtaatatcaa gtgattgatc 1690801 aattttatga ttttgcggcg attggaacgt ccgcacccct tcaggctgat aaagaagggt 1690861 agacaaatca agctggcttg ctttccagtg ctcctttgcc cgttcacttg catgaagtac 1690921 atcagtgcgg ccgatcattt catcaaatgt cttgaagcct aacgcagcca tgtactcacg 1690981 aacttcttcg gcaatgaaca gcatatagtt cacaatatgg tcaggatctc ccatgaactt 1691041 tttgcgaagc tctggatttt gtgtcgctac accgacaggg catgtatcca aatggcaggc 1691101 acgcatcatg acacagccga gtacaactaa cggagccgtt gcgaaaccaa attcttcggc 1691161 gccgagcaag gcagccatca caacgtcgcg gcccgtcatg agctttccat ctgtttctaa 1691221 tacaacacgg tcacgaagtc cgttcagcat tagtgtttga tgtgcttctg caaggccaag 1691281 ctcccacgga agccctgtat gtttaatact ggttttcgga gaagcgcctg tacctccgtc 1691341 atagccgctg atcacaatga catctgcagt cgctttggca acacctgcag cgattgttcc 1691401 tacacctgct tttgacacca gctttacgct gattcttgcg tcacggttgg catttttcaa 1691461 atcgtggatc agctgggcta aatcctcaat cgaataaatg tcatggtgtg gcggaggtga 1691521 gattaatccg acacctggcg ttgacccacg gacatcggca acccatggat ataccttgtt 1691581 gccaggaagc tgcccgcctt cacccggctt agcaccttga gccattttaa tctgcagctc 1691641 atcagcattg acgaggtaat ggcttttgac accaaaccgt ccggatgcaa tttgtttgat 1691701 cgcacttctt ctatcatcgc cgttctcatc tggaacaaag cgtttgggat cttctccgcc 1691761 ttcaccgctg ttgctttttc ctccaagacg gttcattgcg attgctaaag cttcgtgcgc 1691821 ttccttactc aaggacccga atgacatcgc acccgtttta aaacgtttga caatcgattc 1691881 agcggattca acctcctcca acttcaaagg cttgcggttt ccgtcaaatg cgaacaagtt 1691941 ccgcaaaaat ccgatgcgtt cttcatcagc cgcttttgta tactgtttaa acagattgta 1692001 atcatttctg cggcacgccc attgcaaagt atgaatcgtt ttcggattaa acgcatgatg 1692061 ctctccgcca tttctccatt ggaagtcact tcccggttca agcgttttgc tgtaatcatc 1692121 ctgatacgct tcccggtggc ggcgctgtgc ctcttctgca attgtttgta aatcgatgcc 1692181 gcctagctgt gatgcagtac ctgagaaata gcggtcgatc acatcgcggc tgattcctac 1692241 cgcctcaaag atttgtgcgc ctctgtagct ttgcacagtt gaaattccca tcttggacat 1692301 cacttttacg acgccctcag taatgctttt tccatatttg ctaaccgctt cttcatagct 1692361 gatatccaaa cggccttcat caatttcctg cttgtaggtc gcataagcga gataagggtt 1692421 aatcgcatct gcgccataac cgattaacgc tgcaaagtga tgcacttcac gtgcttctcc 1692481 cgattccaca ataatgctga ccttcgtacg cagccctttg cggattaagt gctggtgcag 1692541 tgcgcttact gccagaagcg gcggaattgg tgtcagtcgt tcgttcatct ttttgtctga 1692601 taaaattaac aaacttacgc cttggctgat ggctttctct gcctgtgtga acatgtcctt 1692661 taaaccgcgt tcaagatcct ctgaaaacag cacatcaatt ttttggcttt ttaaatcagg 1692721 atgaacaatc gttttcaatg cgtaaaactg ttcattggat aaaacaggtg tatacagttt 1692781 aatccggcga acatttcgtt cacttggatg aagaagatcg ccttccgcac cgagccaagt 1692841 catcgttgaa gtgacaagct gctcacgaat cgcgtcgatt ggcgggttcg ttacttgtgc 1692901 aaacagctgt ttaaagtagt taaacagcga ttgcgctcgg tcagaaagta cagcaagcgg 1692961 agcgtcattc cccattgaac caaggggatc tttgccttct ttaataacag gaattagata 1693021 cttttggata tcctcatatg tgtatccgaa tgccttctgg cgagtaagaa gatcactaaa 1693081 ttgttcttct tctcttgact ccggatcagg atttacttgt acaagctctt cttcaagcca 1693141 tttttggtac ggatactcag ttgcaatttg tgttttgact tcctcatcgg agataatacg 1693201 gccttcttcc aggtcgatta aaagcatttt cccaggctca aggcggtttt tatataaaac 1693261 gttctcctgt tcaacttcaa taacgcctac ttcagatgag aaaataatat aatcatcttt 1693321 tgtgacataa taacgggccg gacggagacc gttccggtca aggatcgccc cgatttgttt 1693381 accgtcagta aatgaaatag ctgtcggtcc gtcccaaggc tccatcaggg agctatggta 1693441 ctcgtagaac gccctttttt ccttggacat atgcgtattt tccgtccaag gctctggaat 1693501 gagcatcatt gccgtatgtg ccggtttgcg tccagccatc acaaaaaact caaatgcgtt 1693561 atccaaaatg gaagagtcac tgccatcagc attgagaatc ggcaaaatct tgtttaagtc 1693621 ctcaccgaag ctttcagaaa caaattgctg ctcacgtgct ctcatccagt tgatatttcc 1693681 gcgaagggtg ttaatttcac cgttgtgaac caaatagcgg ttaggatgcg ctctttccca 1693741 tgtagggaat gtattggtac tgaagcgtga atgaacaagc gcaaaagcag aaacgaatgc 1693801 ttcgtcttgc agatcagaat aaaatgcatc aacctgttca ggtgttaaaa ggcctttgta 1693861 aacaatggtc tggcttgaaa gactggcaaa ataaaaatca agaccttccg ttactcccca 1693921 attttcagcc tgtttacgaa tgacatacaa ttttcgttca aaagataaat tgtcctttag 1693981 atcagaactt gcgccgataa atacctgacg gacaaacgga cagctttttt gcgccactgt 1694041 tccgattttt ccgacattta caggtacagt tctccatcca agaacgactt ggccttcttg 1694101 ttcaattagt gcattgattt gcttttcaat tttttttctt tcatcttcct tctgtgagaa 1694161 aaagaccatt cctaccccgt aacgttcttt ttctggcaga ttgatgtttt tgcactcttt 1694221 tctaaagaaa gcatcaggga tttgaaccag taagccggct ccgtctcctg tatccggatc 1694281 actgccttgc cctcctctat ggtctagctg gcaaagcatc ttaagtcctt gtttgacaat 1694341 gtcgtgagtc tgcttgccct ttaagtgtgc atataggccg attccgcatg catcatgttc 1694401 aaattcagga cggtagagac cttgagcttt tggcatttga ttgtacgtca taattcctct 1694461 cccccgatca atttccgata ataccggtca taaaatctaa caactctata atcattgtag 1694521 gttttcaaaa cgatataaac aatatataat ttagatcaaa agaatctcaa aatgagatag 1694581 atggatgtga gacaaacatg gagctgcgcc aactgcgtta ttttatggag gtggctgaaa 1694641 gagaacacgt ttcagaagcc gctgatcatt tgcatgtggc ccaatcagca atcagcagac 1694701 aaattgccaa tcttgaagaa gaattaaatg tgaccttatt tgagcgtgaa gggagaaata 1694761 tcaaactcac gccaatcgga aaagaatttt taattcatgt gaaaacggcg atgaaagcca 1694821 ttgattatgc gaaagagcaa attgatgagt atcttgaccc gcatcgcgga acggtaaaga 1694881 tcggctttcc tacaagcctc gccagccagc ttttgccgac tgtcatttca gcgtttaaag 1694941 aagaatatcc gcacgtcgaa tttttgctgc gccaaggctc ctataagttt ctgattgaag 1695001 ctgtcagaaa ccgcgatatt gatctggcct tattagggcc ggtgccgacg aatttctctg 1695061 acataacggg aaaaatatta tttactgaaa aaatttacgc gcttgttcca ttaaatcatc 1695121 cgcttgctaa acaaaaaacg gttcatttaa tcgatttgcg caacgaccaa tttgtattgt 1695181 tcccggaagg atttgtactt agagagatgg caatcgatac ttgcaaacaa gcaggctttg 1695241 ctcctctcgt ttccacggag ggtgaggatt tggatgcgat caaagggtta gtgtccgcag 1695301 gaatgggcgt tacccttctg cctgaaagta cttttgctga aacaacacct cgttttactg 1695361 tgaaaattcc aattgagttc cctcaagtaa aacggactgt cggaatcatt aaaccgaaaa 1695421 atagagagct tgcgccttcc gcgaatgatt tttatgagtt tgtcattcaa tttttctcta 1695481 agctggagca gtatcaataa aaaaaatgaa cccgagcttc tatatagaag cttcgggttt 1695541 ttttctgcaa attaatttac aggtaaagaa aaatccacat ggcaaacaaa tgcttcttga 1695601 tcaattagag ctctatttgt cagttccttt ttcttttccg gttcttgaag ctgtacagaa 1695661 gagtaattga cgattccaag gccgatttcc gtcccttttg aatccatcag ccgaacaact 1695721 gaaccgcttt tgaatttccc tttaatcttc tgtacaccgt ctaggtataa actcgattgt 1695781 ccgtttgtta tttttcgtga acaatcatct gataaaatca tttcaccttc cggaccggaa 1695841 ttaaaagcga tccattgctc cttttgattc aacggaagcg ttccttctgc ttcaaaatag 1695901 gtgccttccg cctgttcatg aacggcgtgg tataaaatat cgccagcatc tgcctgacct 1695961 aggaaacctt taatgccaga cgccattacg attttaaacg catcaagctt agagcgcatg 1696021 ccgccggtgc caacgatgct tccagtgtca cctgcgcatg cttcgatgtc aggtgttatt 1696081 tcactcaccc gctgtatctt tttcgcttct ggatttgtgc gcggattgcc gtcatataat 1696141 ccgtctatat ctgataaaat cacaagcata tctgcatcaa tcaatcctgc gacttttgct 1696201 gcgagcgtat cattgtcgcc aaacttgagc cgattgacgg taactgtgtc attttcgttt 1696261 atgatcggga tgatgccgcg ctcgagcagt acattcattg tattcctgac attgttgtat 1696321 cgatattcat cagaaaaatc gcttctcgta attaaaattt gggatgcgac atagccgtgt 1696381 gccaaaaaca gctttgaata agcctccatt agcaatccct ggccgattga agctgatgct 1696441 tgtttttctg gaagcttctc gggcctttgg ataaatccga gcttccgata tcccgccgcc 1696501 actgcgcctg aggaaaccaa aatcacttca taaccggcgt ctttgagttt gacgacctgg 1696561 tcgaccaacg cttctaattt tcgaatgctg atttctccat gaaggcttgt taatgaactg 1696621 cttccaatct tcacaacgac tcttttcatg cttgtatcag gcgtcacttt atcactcctg 1696681 atagcggcgc tgcagttttt tcgatatctt cgctgatttc ctttgaacgc ttagccgcat 1696741 gctttattgc ttgagaaatc gcttctccgc cgccgctctt tttcaaggct tgcagccccg 1696801 ctgctgtcgt tccgttcggt gacgtgatat tatctcttaa gatctcagga tgttctcctg 1696861 tttccatgag catttttgcg gcacctaaaa gtgtctgtgc gccgatgctt cgagataact 1696921 gtttatcgag gcccgcttcc tcgcctgtct tttcaatgaa ttccattaaa taataaaaat 1696981 acgcgggtcc gctgcctgca attccggtga atatatccat ttgattttct tggattgtat 1697041 agacttcgcc catgcatccg agcaatgctt cggccagctt cttcaggtct tccgacacat 1697101 atttgccaag ggcaatagct gttgcagaag cgccaatcat actggaagtg ttgggcatca 1697161 ctctgacaac cggctgttca ttaagcaatg attgttcaat aaaagaggta gttatgccgg 1697221 caaggaccga caatattaat tgatggggtt gaatacgtga ttttagtgat gacagagcgt 1697281 tttcggcgtc ttttggcttc attgccaaaa tgagcacatc catgtcttca atacatagtt 1697341 ggttcggcaa ggcgccttta atgccatatt gaagttcaag ttcagttaat cgctctgtat 1697401 tgctgcggtt tgtaacgcag atgttttgtt tcgggatttt gttggctcga acgatacctg 1697461 atatcattcc ttccgccata gatcctgctc ctataaaggc tactttcttt tgatcaaaga 1697521 tcggtaacat ctcctttgtt cgcttttttg ttcgcatttt cacacgttta aaatgttacc 1697581 acgtgaggaa atgatgtcaa gtttgaaggc cattattgat ttgtattgtt tcttttcgac 1697641 aaatatgtat aatgaaaagc agaaaacacc cggttcacac tgctgcgccg ggtgtttgtt 1697701 tctattaaaa attatctgag agagcttttt caatcagttt tttacagcga tccagctcta 1697761 ccttcagctg ttttttatat agcttggcag cttcgtaatc tttaaattga tagaggacga 1697821 cttcctggag cttagcccct tcttttttta ctttaatttg ttttagtatc ccgtcatcaa 1697881 gaagctcatg caaagaccgg tatacttctg tatgatttgg tttaaaacca atctctttaa 1697941 attcagaccg aagtacttca agcagcttta acccatagag tctctcttgc tctgtcatcg 1698001 ttatcatata aagcttcaaa aatgcgcgct gtttcactaa aaagcctgtt gaactccttt 1698061 tttcttcttt catcatatgc actccttctt ctgtcactga caacactatg tactaaatat 1698121 tcaattttct tttattgttt tccttcttta tattaaagac tgatagtcca gttatttcat 1698181 gtttactgat tataggtgta gcggaaaaaa taaatttcga ctgaacattt ggtacatagt 1698241 tttcttagtt ctattatagc ctgcatttac tgctatcttc aatttaaacg attgccaggg 1698301 tttacatatc tcattttacc ggtacggatt tcattcaaat aaaaaaacct gtcgaaagac 1698361 aggttttcat ttttaaggat ttgttgacca taatcccgct gttttgatga aaatacgagg 1698421 atctaatttc agttgtgcca ccatgtactc agcaagatcc tcaggctgca taactttttc 1698481 aggattaccg tctgttaagt tcaattcgat agacatatca ctagcgacag tgctcggcgt 1698541 taacgcgctg actctgatat tatgttttct cacttcttgc ataagagact ctgttaaccc 1698601 gagaacggca aatttagaag cgctgtaagc acttgttaca gcagctcctc tttggcccgc 1698661 tgtagatgaa atattaatga tgtctccggc tttgcgttcg atcatttccg gaagcaccgc 1698721 gcgagtgaca tggtacacac ccattaggtt gacttgaata atattttccc actcatcagc 1698781 tgacagatct aagaaaccgc caaatttgct gatgccggca ttattaatga ggatatcgat 1698841 atcaccgagc tgttccttca cttgagctac agcttggtta acctgatcgg catcttttac 1698901 atctgcagca gcaaatgcag cttttacacc aagcgctttg acttcttcag ccactttttc 1698961 tacattagcg gaagtccggc caattaaccc gatattcacg ccttctttgg caagcgccag 1699021 agcagtagcg cggccaattc ctctgcctcc gcctgtgatt agtgcagttt tatgttgtaa 1699081 actttgcaat tgaagcaccc tttctttgtt tacatatgta cgatatcaca ttataagtac 1699141 aatacatcca atacgcaaat caaacgaact gtgtaaatat catttcttct gattaaaaaa 1699201 acggatacag ggtaatgaca taagaaaagg agtgaacata tgattatagt ttatatcagt 1699261 cttgcagtat tagcagtttc tattatcttc ttaggagtta ccgtgatcca aaacaagaaa 1699321 aaaatagacc ccgcactaaa ggagctttcc tctgttacgc aggctatgca aaaacaaatc 1699381 gaaggattaa aaacagaaac agagctgctg acgcaaaaac aaaagaagat tcagcaggat 1699441 gtccaaataa aaaaatacac gcttcagcag accgcagctg aagtgaaaga agttccccaa 1699501 gcagtcaaag aggtgtggca ggcaggacat tttaatagca gataaggatg aatgagatcc 1699561 cgttgttacg atcagaatgg acaaatggga tctcattttt cgaggaggct tacacatgat 1699621 tataaaccgc agctgcttaa aagagttcgc agaaaaagta cattttcttc cctcttcact 1699681 tacaaagtcc gatttactta ctgatccatt tcgtctccat caagaaaacg aacttggcat 1699741 ctactattca cctcataatg aatttatcaa tcgggatgcc tcgcttgtga ttgccgggat 1699801 cacgcctggt ttttcccaga tgaagacagc gtacgaaaca gccgccgaaa gcctgctgca 1699861 aggcgggact cttgagcaaa tggcagtaga cacaaaaata gcagcgggtt tctccggatc 1699921 gatgagacat aaccttatta ccatgctgga tttatgcggg ctgccgcaag cttttggcat 1699981 tcaaagcgcc gcaaagcttt ttggagaatt acggcatatg ctccatacaa cttccgttat 1700041 taaatatcct gtctttatcc agcaaaaaaa ctataccgga tacaaaccgg ctatcactca 1700101 ttctcctatc ctaagcactt atgcttttgg gcacttccct gcagagctta accatgtgac 1700161 gggaccagct cttctcattc cgttaggaaa agcggccgaa acagtgtgtg aaacattgat 1700221 cagacagcac agcctccaga atttgatttg ccttaacggc tttccccatc catcaggcgc 1700281 gaacggccat cgtttgaaac aattcagcaa aaacaaagag caactagaaa gacaaattcg 1700341 ttcctttgct gcattggttg atttcgctat agaaaagagg aaataaaagg gatatgataa 1700401 acaaaaacac aaacgtgggg agtggttgaa tgtttcctat attagaaacg gatcggctta 1700461 tacttaggca aatcacagat caggatgcgg aagccatttt tgcttgtttc tcaaacgatg 1700521 aggtgacacg ctattatggg cttgaaaaca tggaatctat agaacaggcc atttcaatga 1700581 ttcaaacgtt tgctgccctc tatcaagaaa aacgcggtat acggtgggga attgaaagac 1700641 gggacactaa agaactgatc ggaacaattg gctttcacgc tctggcccaa aagcataggc 1700701 gcgcggaaat cggttatgaa atcatcccgg agcattggcg aaacggattt gcatcagaag 1700761 tcatttcaaa ggtcgtatct tacggatttt ctgcccttgg actgtcgcgt attggcgcag 1700821 ttgtatttac cgataatgaa gcatcaaatc gtctgcttct aaaaatgggg tttcaaaaag 1700881 aaggcgtttt aagacagtac atgtatcaaa atgggactcc atatgataca aatgtgtact 1700941 ctattgtgaa accaagagaa tgacggtatt ctcttggtct gtgccacatc ccttttcctt 1701001 taaaaagata aaaagcgccc ctcaaacagg gcgctttcta attaagatgc atattgagga 1701061 gatgtttcct ccttaactgc tttttcctca ggtatatgaa tacattttgt caagaccgca 1701121 cttgcaaggt aaagggccgc aaagatccag acgacacctt gcgcgccgac gagaccgatg 1701181 aacagccaag cgagtgcagg gccgacaaac gctgataaac ctgcagctaa attcaataca 1701241 gacatggctg cccctttatc ttttcctgcc accgtcggca caattgcacc aatcggcaca 1701301 tagcctgcca gcaaaccgcc ccaaataaag ccgatcacgc tgacaaccgc taaacttccg 1701361 ccggagaaaa caggtgcgta gtataataag acggtgaaaa tgccgcagcc gactccgccg 1701421 aaccaaataa cagtattttt ccagccgaat ttatcgccga caataccgaa gataaggtta 1701481 aacacaatgt tccccaggaa aatcgttccc caaatttgca gccacacatt ggttgaaatt 1701541 ccatgctggg ccatgtgcat cggcaaaaag actggaaaac catatgtacc aatgctgttg 1701601 atgattctga tgattccgcc tgtaagcacg cgcggatttg taaatagaat cgtaacccct 1701661 tttaaaagct cctcggctgt ttctgatctt tttcttttct tcttttcaaa acggtcttta 1701721 ttgataaaca atgcaaagaa tgcaccgaga catacccaga aaatagagct ccaaagcgta 1701781 ttcaaataac cgaacgcttt gatcgcgtag cttgagtacc aagcgccgaa cacaaacatg 1701841 ccgaggcaat atgcaatcca aaaccagccg acagcagtgc tcagtttgct ttgcggtgtt 1701901 ctgtaaatga cccatgtcaa gaaagaataa gcaaaaagcg ggtaacctaa cccttttacg 1701961 aagtaagtca catacatcac tggcaggttc agctgttcaa atccaaatac gataaaagca 1702021 gctgtaccga tcacataaaa caacagcccc ataaacatcg ttcgttttgc gccaaatgct 1702081 tcgagacata cacccgaaaa ccaggaagct atggcaagcg caattccgta tatactaaaa 1702141 atggaagcgg actgctgaac ggtgagcccg ttttcgatca aaaaaggact gagccagcct 1702201 tgttcaaggc catctcccat cataaacaaa acaaccccta aaaatcccca ggcaagccgc 1702261 ttcggtattc ctattttatc caacatatct gtctcctcct tagatgctat tattcattac 1702321 cgtattacct tattaaagtt gaaaattaaa tgattcctca aaacagcaga aattccgtct 1702381 taaattaata ctttgctttc tgatcctgaa aaaaagcgct gtgtttgctt ccattcctca 1702441 tataaagcca attctatctg acagtccttc ggttcgatca cccggacatt tgctgacatc 1702501 tcctccgtta attgaaaggt ttcattgcaa atgactgcag caccgacgac agatgcctga 1702561 tgatatccct cttggacata gacctttttt tgaagaagat ccgcgatata ttgagtgagc 1702621 gctttgcttt ggaatccccc tccgcacacc caaacataat cacgttcaaa cggagtaacc 1702681 tctgttaaaa tgtcaaagtt ccatttgatt gaaaatgcga tctcttctag cgctgcacgt 1702741 acaaaatgtg ccctctttaa atgtgctgac agcggggcat caaaaagaaa accgcctctc 1702801 gttaacgcat tcttttcagc cgataaataa gagccgagag ccgctacaca tgcatggtct 1702861 tcttttgcaa gtgcagaaat ctcctcctcc attacttcgt acgtttcatt cggataaaaa 1702921 atctgtttta atttttgata attcaagccg gtaattcccg gattcgtttc cacaagccaa 1702981 tgcccttgat ccgtatgaca gttcaaccag gctttatgtt ttgtgtcgcc atgatcctca 1703041 gtaattttgg ttattggcgt tgttgtccct gatacaatga caatgtcctc aagtccagct 1703101 ccggtgcttt tgacagccag ctgtgtatcc ccgccccctg ctataacctt agcatttatt 1703161 gaaaggccta attcggatgc atattcattt gctatcgttc caattgctgt tcccgctctt 1703221 acaagaggcg gaaggataga tggagaaaag ccgaaaatgt cgcacatctc ttctgaccaa 1703281 gtgttttgct tcacatcaaa tagcagggtt tctgttgcct gtgatggttc atatgttaat 1703341 attccgctca gttggtacgt cacccaatca ctgatgcttg taaagcttgc agtcttttcc 1703401 cataaagagg gctggcgctg ttttaatcca taaagcttga gcgcagaaaa aagtgcagtt 1703461 ggcaggcggc ctgtgctgct gtatatctct tcccaatcgg gaatgcccgc ctcccactct 1703521 cggccgcgat tatcgatgtt cggcagcccg agaaaaggat tgccgttttg atcaatcaaa 1703581 acaatcccct gtctttggct cgtcgatgtc aaaccaatga tgtcaatatc acacgaacgg 1703641 gatagcgcac gttttgccaa attcatcacc tgcttccaca gcacctgagg agaaaaataa 1703701 cggctgtccg ggtaaagcgt ctctgtggaa tactcgatgt cctcccgttc aactgttaga 1703761 acactgccag ttacactcac gaccgctacc ctcgcattgc ctgtgccaat atcaaaaacg 1703821 agatagcctt tttgtttttt cattctgtta gcctcctttc ttatccccct gttttcagtg 1703881 cgtccttgtt atacattgtc tgaatattaa gagttttttc acccttccac tttttgaggg 1703941 ctttattcag tatcgtcacg tgatgatcct ccacttcaaa tgttgctcca gcgagatgcg 1704001 gtgttgccag aacattaggc aatgaaatca attcataatc tgattcctct ggaggttcat 1704061 gataaaaaac gtctagtatc gcaccgctga ttttatgttc ttttaataca aataaaagat 1704121 cttcacggtt tacaacaact gctcttgaag tattaacgaa aatcgcactc tctttcatca 1704181 gatcaaaata ttgccgatct atcagtccga gtgtttcctc agtgcgaggc agatggacag 1704241 aaacgatatc gctgtctgaa aacaccgttt taagagatgc tttttcatac aacggatgat 1704301 cgtcttgaat gtatggatcg taatatttta tcttacagtc aaacgcagtc agcagttttg 1704361 caatcctttg cccgactgcg ccgaacccaa tcatgccaac cgtttttcct gttagctcat 1704421 ttcctttaaa tttgacataa gcctgcaggt aatcactgtc ccactctcca tccttcagcc 1704481 actgattcga ggcgctggta tggcgcagaa aggaaatcac atttccaata aacatttcgg 1704541 caacggcttg tgcattccgc cctggtgtat aaaaaacagg tatgcccctt tttgaggcag 1704601 ctgccacatc cacatttgag ggcattcccc tgcaaacacc gacaaatgaa agttcgggaa 1704661 cagaagcaaa tacgctgtct gttacctgat caagttcagt aatcaagcct gtcgcatttg 1704721 ttgcttttag cagctgaatg agttcatcct cccgatatgc cctaccttgt tccttccaag 1704781 attgataagc aactgagcca aacaagtttt caagctcttt tcgtccttct tcgttgtacg 1704841 gtgctgtaac caaaaccgtc atgctgcaaa acatcctttt catcgtattt ttcataaaaa 1704901 aaatctcttt ccgaagatgg aaagagattc atatataggc gcgctctgtt acaggcagac 1704961 gccggtataa accttgcttt cctatctttc aagctagcgc ttgctggaat tggcacaata 1705021 atgttgccga ggtttcatag ggccagtccc tccacctctc tggatagaaa atattgagta 1705081 tgtaattttc agaatgaaga atacgtttat cataaagaag actcagattg atgtcaatct 1705141 ctttttttca gaattgacgt tatcatcgga aatgttataa ttcttacaaa atatctaact 1705201 agagagagga actgggccat gagatctttt gccacacaac aaaacggcat tttcaaatcc 1705261 gtttgctcgc tggactgccc ggatcagtgc ggattgttaa tacataaaaa agacgggaaa 1705321 atcgtaaaag tgcaaggaga ccctgatcat cctgtcacag ctggaaacat atgcaacaaa 1705381 gtccggaata tgacggagcg catctatgat gaaaagcggc tgactacacc gctcaaacga 1705441 acaggtgcga aaggccaagc gatatttgaa ccgatttcct ggaaagaggc aatcgatacg 1705501 atcacctccc gctggaaaca gctgattgat gaagagggag ctgaaagcat acttccttac 1705561 agcttttacg gaaatatggg gaaattgaca gctgaaggaa tggaccgccg ctttttttac 1705621 cgcatggggt caagccagct tgaacggacg atttgcagca aagcgggatc tgaaggctat 1705681 aaatatacaa tgggcataag cgcgggaatc gatcctgagg aaaccgttca tacaaaacta 1705741 tttatttttt ggggaatcaa cgcggtcagc acaaatatgc accaaattac gatcgcccaa 1705801 aaagcgcgaa aaaaaggtgc caaaattgtc gtgatcgatg tgcataaaaa tcaaacagga 1705861 cgtcttgcag attggtttat cccaataaaa ccgggaaccg acagtgcact tgctcttggc 1705921 atcatgcaca ttttatttaa agaaaacctt catgatgaag catttctgtc cgagtacacg 1705981 gttggctatg aagagctccg tgaacacgtg aaacaatatg atcctgaaaa ggtatcgacg 1706041 atcaccggtg tcagtaccga agatatttac cgactggcaa aaatgtacgg ggaaacctcc 1706101 ccttctttta tcagaatcgg aaacggaccc cagcatcacg ataacggggg gatgattgta 1706161 aggacgattg cctgtcttcc ggcgatcacc ggccaatggc tgcacacagg gggcggcgca 1706221 attaagcata acagcggaat tttagaatat aacacaaatg ccttgcagcg gcccgactta 1706281 ttgaaagggc gcaccccgag gtcgtttaat atgaatcagc ttggcagggt gcttttggaa 1706341 acagacccgc cgattcgctc tctatttatt tacggaacga accctgccgt cgtcgcgccc 1706401 gaagcaaaca aagtcagaca gggcttgctg cgggaagact tgtttactgt ggttcatgat 1706461 ttgtttttaa cggaaacggc tgcatatgcg gacattgtac tgcctgcaac atccgctttt 1706521 gaaaatactg atttttacac ctcctactgg caccattaca ttcagcttca gcagccggtg 1706581 attgagagat atggggaaag caagtctaac actgaggttt tccgattact ggctgaagcc 1706641 atgggattca cagaccagga gcttaaagat tcagatgaag tattaatccg ccaggcgctt 1706701 gaccatccag ataatccgca tttggcagag attgattacg attcacttac taagcattca 1706761 tttatgaaag cgaaacgtga aaagccgctg tttccgggcg aacttccaac gccaagcgga 1706821 aaaatagaat tatattcaga aaaaatgaaa caagacggct tccctgcttt accgacatat 1706881 acacctcttg taaccgataa tgaacatccg tttatgtatg ttccggggcc aaaccataat 1706941 ttcttaaact caacattttc caataatgaa aaacacatca agcttgaaaa gacgccaaag 1707001 ctctttatca acacaaaaga tgctgaaaaa cacggaatcg ttgatggggc acctgtacga 1707061 atttggaaca gccggggaga atgcgagctg accgctgcag ttggagaaca agtgctgcca 1707121 ggtgtcgttg tcagccaagg attatgggcg gatgaacaag gaaaaaaaca gcttgtaaac 1707181 gcgctaaccc cagatcgctt gtccgatatg ggcggcggcg ccaccttttt ttcaggccgt 1707241 gtacagattg aaaaggtttg aaaaataatg aaacccggag tatgccaagc ccgtataaca 1707301 taacatcgac ataatggagg catacacatg gacgtttttt taggaattgg tattgctttg 1707361 gctggatatt ttatcggtga aggcttaaag cagaggaacc aaaccaaagg taatgaacaa 1707421 aatgatatct tcctaataaa agaacgggat atttactttt acattggact ttttttagga 1707481 ataacaacga ctgaagcaaa acagttagct ggagacatgg cagacctgcc ttacatcgaa 1707541 ataaacggaa aaaaatatgt ccagaaacat atgttaaaag attggacatt cacattagtt 1707601 gaaaaacatc agggtgaata aaacaaatct gaggagagcg agattcattg tcacgctctc 1707661 ctctgtttag ctgtatggat cctgccacca aaactttgtg ctataagcgc tgataaaacg 1707721 ataaaccacc atctatgttc tttcctcaaa caactcaaga tgcccgttcc acaacaatag 1707781 tttttatatt cctttgatga cgtgatgttc ttgatgaacg tatgtatcgt aaaacactta 1707841 gaaaacctat tcggtttgaa tgtgtgctct cattatgccc ccatactgcg cctttatccg 1707901 cggaggattt ttttaaaaaa atatgaaacc taaagctttt agatcctgaa tttttattga 1707961 acctccatat ttctccgatt ggtaaaaatt agcctataca ccggaagctg tacgtttata 1708021 aaggatcaga gaatcccata accagtaaat cactgcagcc gcaatactta acatataata 1708081 aaagtacgat tgcaatgtcc atgctattga cgcaggttca ttgataacaa aaaacaggaa 1708141 agctgcgata aaagcaacca cactgtaaat caataggtac atgacattga aagttctcgc 1708201 ttttttctgc aacttcattt ggagcggaac agcaaaaagg ccatacacca caaaaccgta 1708261 taataaagca attgctgccg taaacaatgc aattatcata tcgccataca taacgaaaga 1708321 ataaaaccct aataacaaac caaatgtaag gctggatagc cctaatgtca ttaaataata 1708381 tgatgcgatt tttttcattt tttcaccccc cttgtttgat ttattcacag tgctgttagt 1708441 ataaattcac aacctttgta tttcttttat cgagatgtct tccctaacgt gctatacgca 1708501 atgcgctaat aaaaggtttc aaaaatgacg ttcttttatt agataatacg ctggctgaaa 1708561 acgcctctcc tgattggcca aagcgcgaat gaaaaaagtg catgaatacc tgcccaacag 1708621 acagaataag aagagttgat atttcaacac ttttcgtaaa ggggtgaaac caatgagtaa 1708681 gaaaggtatt caaaattcaa gtattgaaca aataagaaat gaccatgaga ctgaaacagc 1708741 ttttaaagca gatgatccta aaaaacacgg ttccgatcct aaaagaacga aataagttct 1708801 tacccccact aaaatatcaa taatctggag gaagtaaagt gactcaaaaa aacggtgcag 1708861 acagacctga tgattataaa agattttctt cattagacaa ggaatatgat tttcagcaat 1708921 ctatacgcag caatactgag acagaaagtg taaacactga aacacaaact cataacaaag 1708981 aaaacaaaaa tgacacaaca gatgttgccg ggaaatactt tgagccctca gattataaag 1709041 gaagcacgca attagaaaaa ggattggctg aaactcatga acaggtcagc gatgactatt 1709101 ttgaagggac aatcgatcaa aatttggact agccatacaa acggaactaa cttaaaagaa 1709161 gtcagttaac tctgttttta gaaacaacca cagtaaaagt agccaacccc caccgaataa 1709221 gatgggggtt gcacgtaagt agcctgttta atatttaaaa cgattaatga cggtttgaag 1709281 ttcttctgcc aactgagata gagattctgc ggcataggag atttccccca ttgaatgaag 1709341 ctgttcctgt gatgaatttg caaccgcttc tgtatttgct gacgtttctt ttgtaccagc 1709401 agccaatgta tgaactgtgt gctgaatcac ttcaacgcct gaagtaagct gttgagttgc 1709461 tgctgcaact tcttgtattt gagaagtgac ctgttccacc aggttcagta tttcattgaa 1709521 atttcctgtt gtctcttgag aaagaacaat acctgagctc acattttctt gaacaacttt 1709581 aatattattt accgtttcta tcgattcgtt ttggatggtc gctaccaccg attggatgtg 1709641 gtttgcagat ttatttgttt catccgccaa cttccgaact tcttctgcca ccacagcaaa 1709701 tccttttcct tgctctccgg ctctggccgc ctcgatcgct gcatttagtg ccaacaaatt 1709761 tgtctgctct gaaatcgtcg tgataagcga agagatatcg ctgatttctg ctgtgctcgc 1709821 taccaatgtt tgcaatccat tgccggctga atctacagat ttatcaatga atttcatctg 1709881 gtctaacatc ttgttgacgg acttagagcc tatttcagcc ttgtctctca tcgaagaaga 1709941 aagatccgct atgttccctg tatttgaagc gactgatgat atactgtcta ataattcagt 1710001 gatggattct gcgctctttt ctgtcattga gctttgcttc acattgctgt cggcagccat 1710061 ctgcatggct cgtgaaatat gttcagatgt tgatttcgat tcttccgcgc ttgccgataa 1710121 ttcttcagag gaagcggcga cttgttcaga tgagctgctg atctgcttca caatttgagt 1710181 taatgaatga gtaaaagaat taaaagattg ggcaagctgg ccaaattcat ctttattttt 1710241 cacaatgact tttttggtta aatcagcctc gccgtgtgca atttcctcca gctgcttatt 1710301 tatgcttctt agtggcacca taatggactt taacagcatt atgcttagaa caatgcctaa 1710361 tattactgat atccctgtga caatgataat gagcgattga ctcattttcc cattgccctg 1710421 tatttcatcc tttagatcct ctacctcttg atccaggcga tcagacagct tattgacagc 1710481 cggagctacg ccttcttttc ttattgttct ttcttctcca aaatggatgg tttctgcttt 1710541 tttaggattt gaagagtagg ctgttactac ttgctgattc aaagctctat actgagtaaa 1710601 acttgtctta atgtcttcaa tattggattg atacttctct tcatcaatca agtcattaac 1710661 ccggtcaagg ctctttaaga catcgtctgc ttttcccttc ataccctcgt cgtattcttt 1710721 gtctctggta atcaagaagc ctctttcatc atttgataac ccggtcaatt catattggat 1710781 gtgttttatc tctttttgga attccatttt gtctttaagt tcttcattct ttttcacagt 1710841 agaagaaatc ataaatactg aggagcctcc aattccaata attgaaacaa ctaatattga 1710901 tataatcccc agcaattttg ttttcacttt catgtgtcgt tttccctttc cgcacaatgt 1710961 aatggctgaa ataaaatatg ttcaagcgcg tttgaatcca attcgcttac gctcatgtcc 1711021 ataatatcga cacgtgttat caagttttat agtgatattc ttatatgaat aagcaaattc 1711081 tttacgtctc tgaacttaca gaaaaacctt aagtaaaatt tgcagtcttt tgcggtatgt 1711141 aagtcactct tattcgtttt tctaaaaaag gcttttccca cctcaaattg gctgaaccgg 1711201 ctgttttctc gaaaatataa tacaatacgc agcataatat gaaggagcga aacttaaatg 1711261 gggatcatca atggtaaaga attcattgac cgattgaata aactagaaaa cgaaatatgg 1711321 tatgatggcg aaaaaataaa gggtaacatt tctgagcatc ctgcatttaa aggaataatc 1711381 aaaacaaaaa gctcacttta tgaattgcaa acaaaggatg agttaataca tgaaatgact 1711441 tattgccttc ctggagatca taatcgaatc ggcctttcct atctccagcc taaaacaaaa 1711501 aatgatttga aaaaaagaag gaccatgatt gaacattggg ctagacatac tcatggaatg 1711561 atggggagaa gtccggatta catgaatacg gttatgatga gctttgcttc gtcagcggag 1711621 cttctaaaag ataaagagaa ttgctttcct gaacatatac tagatatgta tgaacaagct 1711681 gctaagcatg acctttcctt tacccataca ttcattactc cgcaagtgaa ccggtcacag 1711741 tcctattttg ggctaagtga aaaaccgata tctgctaaag tcattgatag aaccgaaaaa 1711801 ggtttaatga ttcatggcgc acgactgctt gccacacaag gcgggttgac cgatgaaatc 1711861 ttggtttttt cagcgcctaa atttttcttt gaaacagatg aagcttatgc tttttcaatc 1711921 ccttctaata caaaaggcgt aaaattcatc acaagagaat catttgtatt aagcgactct 1711981 tcctttaatc atcccttaag ctcaaggtat gaagaaatgg attcaattgt ggtttttgat 1712041 catgtgttag tgccgtggaa tcgtgtgttt ttttacgata atgtggaagc agctaaagat 1712101 tttatgacaa aaagctcttt tcatgccttt acctttcacc aggttgtcat taggcaaatg 1712161 ataaaaattg aatttctatt aggtgttgca cagcttcttg tcgacaccat taatgtttcc 1712221 gaatatcagc acatccaaga aaagctctca gaaatcattg tgggattgga aacaatcaaa 1712281 gccctcattg acaaatcgga aaatgatgct cagttagatg aattcggcta tatgcgcccc 1712341 tgtttaattc ctcttcaagt catcagtacg atcattccta agctatatcc tcgatttact 1712401 gaaatcatac aattaattgg agctagcgga atggtgacac tgcctaccga aaatgcattt 1712461 gactcagaga tacgggaaga tcttgaccaa tatcttcaag caaccaatac aaatgctgaa 1712521 gaacgtgtga aaattttccg tttggcatgg gatttaacaa tgagttcatt cggaactaga 1712581 caaactcact acgaaagata ttttttcgga gatcctattc ggatttcaag caggctgtat 1712641 accagttatc caaagcagga gcagttgaac atgattaaaa catttttaca tgcagataca 1712701 gaacattgaa aaaacagcgg gaaaagatcc gctgtttcgt attttttatt caggaaactg 1712761 aacatggccc ggtactgtat aggctttgga cgttccgctt tcaggcagct ttggaatggt 1712821 gtctttcaca acttttccgc ggatgtcagt cattctgact ttgagagagc cagtacctaa 1712881 attcgtactc acaaaatggt tatagtccat tttctccatg ttgatccact taccatcctt 1712941 ttcatattcc attttcataa caggatactt gtgatttctg acttggattg ctgcccacca 1713001 cctgctgctg ccttctttga tccggtacgt gaaattgccg gtgattgggg ctttgacaac 1713061 acgccattta atattgattt ttccgtcttt catattgccg attttacgga aggcattagg 1713121 tgacagatca agagctcccc gagcgccttc gggataaaga tcagtaacat atacggttgt 1713181 tttccctttt ggcccttcaa cttccaaata agagccggca agtgccgctt ttactcctcc 1713241 gtaattgaga tccgccggat ttattgcagt aatctccata tcggaaggaa tgggatccag 1713301 caggaaagct cctcctgaat agcctgaccc tgtatacgtt gcataacctt catgcaggtc 1713361 gtcatatgct gccgaagctt gcggggaaaa acagaagatc gtcaacaaaa ccataccaac 1713421 aaatgcactc atgatctttt tcatatttgg tcctcctcaa accagacttc aaatgagaat 1713481 cattatcatt ataagactca atccatctgg tttgaaagag gaaatagatt catagttgat 1713541 tttaaggcaa attcactatc attcatatat caaatgtagg tacttatgaa aaagccaata 1713601 caaatgaacg aatgtgcact tcagccgaat gtcttatttt tccctctcaa aattcgcatt 1713661 tcaataacga aatgaaacag gctgttggcc tgataacagc tatacaggaa aagctatttt 1713721 tccccgctca gtttcaactt agctgtcatc atgatgccaa agatcagcac aatcggaacc 1713781 caaataatga agtgataaaa atcaggctca gccagagcaa caataatagc ccctacacaa 1713841 tacaaaataa tagccagtgc tcttaacaca gtatctctta agaaagtctt cttttgcttc 1713901 ttaaaaaaca aacggccgga tatatcctct aaaagagaag ccaaagtgcc ggtcaacaca 1713961 gttgaagaaa tacctgcaat ccccagtttt tttgctgctg tagtttgaat ccccatagaa 1714021 atgctcatga gtataattag aatgtgcaca ggaacaaatg cccggtaaaa agaaagacaa 1714081 gcaaagacaa acaaaatgaa tgcttcaagt gcgagggctt ttgtcacagc agaaggccaa 1714141 agggtatttt ccgcctttcc gaccatcaat gtagcaatga tcacgccgca tataaatccg 1714201 attagcgcag tcaaggaatt aaaaacagtg acctgaatgg atttgccgat agctaacccc 1714261 aataatacaa tgtttccagt catattagct gtgaacacat gtcccaggct taaatacccg 1714321 attacatcca cgattccagc tgttaaacat aaaagtgata gcaaggtgtt tcgataagct 1714381 gctgcagtca acggtgtatc aatcctttct tctatttcaa ttgttagtat gtcttttggc 1714441 gcaatctcta ttttttaagt aacccaacat taattaggaa gatagaacct attattcctt 1714501 tccattaact gtaataataa tccccgcaag gaaatgatta aaattgaaag gaagcatatt 1714561 gtgatgaaac gactttgttt atggttcacc gtctttagct tgtttttggt tctcttgcct 1714621 ggaaaagcat taggtgcagt cgattttccg aatacctcaa caaatggcct tttaggtttt 1714681 gccggaaatg ccaaaaatga aaaaggcatc tctaaaacgg gcacaacggg tggaaaaaac 1714741 gggcagattg tttacattca aagcgtaaat gatttaaaaa cccatctagg aggatccact 1714801 ccgaaaattt tagtgcttca aaatgatctt tccgcatctg cgaaaacaac agttaccatt 1714861 ggctcaaata aaacactcgt gggctcttac gcgaaaaaaa cgctgaaaaa tatttattta 1714921 acaacttcat cagcttttgg aaatgtcatt tttcaaaatt taacgtttga acacagtccg 1714981 cagattaacg gaaataatga tatccagctt tatttagatt ccggtatgaa ctattggatt 1715041 gatcacgtca cattctcagg tcatagctat aatgcaagcg gaagcgattt ggacaaactc 1715101 gtgtatatcg gaaaatccgc agattatatc acgatcagca actcaaaatt tgcgaatcat 1715161 aaatacggtt tgattttagg atacccggat gattctcagc atcaatatga cggctacccc 1715221 cacatgacaa tcgccaataa ttattttgag aacttgtatg ttagaggccc aggtctgatg 1715281 agatacggtt actttcatgt taaaaacaat tacagcaata attttaacca ggcgattaca 1715341 attgctacaa aagcaaaaat atattccgaa tataattact ttgggaaagg cagtgaaaaa 1715401 ggcggcatcc ttgacgacaa gggcactggt tatttcaaag acataggcag ctatccatca 1715461 ctcaacaagc aaacctctcc gctgacttct tggaatcctg ggtcaaacta tagctatcgt 1715521 gtccaaacgc cggaatatac aaaagaattt gtcacgaaat atgccggatc acaaagtaca 1715581 actctggtat ttggctactg atataaaaga ggccctgcgt taaaaacgct gtgcctcttt 1715641 ttatactata ggctattttt aagcgatcct tgtaattcca tcaagatcca gcgtcggtca 1715701 aactaaaaag catatgttct tttccacaat aacttcttaa ctggctttct tattatacca 1715761 gtttatcgca agtgaaaaga aatcattgtt ctgaacctgt attaaatgaa cgatcgtccc 1715821 acaaactact taaaaacccc taaaaaggat gatggatatg tgcggcaggt ttactttgta 1715881 ctctgcattt gatgatatta ttgaccagtt tgacatcgat caattttttc ctaaaggtga 1715941 ataccagcca agctataatg tcgcaccatc acaaaacatc cttgcaatca tcaatgatgg 1716001 atcaaataat cgcttaggca agcttagatg gggacttatt ccaccttggg caaaagatga 1716061 aaagatcggt tataaaatga tcaatgctcg agccgaaaca attaccgaga aaccggcctt 1716121 tcgaagaccg cttgtcagca aacgctgcat cataccagca gacagttttt atgaatggaa 1716181 acggcttgat tccaaaacca aaatcccaat gcggatcaaa ttgaaatcat ctgctctttt 1716241 tgcgtttgct ggcttatatg aaaagtggag cacacatcaa ggataccctc tttatacctg 1716301 caccatcata acaactgagc ctaatgagtt catgaaagat atacacgacc gaatgccggt 1716361 tatattggcc catgatcatg aaaaggagtg gcttaacccc aaaaatacaa gccctgatta 1716421 tctgcaaagt ttgctgctgc cttatgatgc tgatgacatg gaagcatacc aggtttcatc 1716481 attagtaaat tcacccaaaa ataattcagc tgagcttctt gatgcagaaa atcatatgta 1716541 gtgattgaaa aaattctcta gcaagaactt gtcaaatagc tttgttcctt aggtgccaat 1716601 ccctctagta attatgaata tttagtacat agatcaatta gttatcttta gcatcagttt 1716661 gaaataattt tattatgtaa acttaaataa gcaatgttat tcctttcata taaaatagtt 1716721 tacattttta taaaatcgct tcacttttct attttgtcag caaaaaaact gaaccacatt 1716781 aaacttatga aacctgccgc acctgtggat tgcaaatatg atataagccc atagaggtaa 1716841 atccatacac tttccctcct aagaattaaa tgaaatttct ttcatcttac atgaaggtct 1716901 tctttctttt gtttatccag tgtaatactt aataatatgt tgatgaatgc agctggaaaa 1716961 tatataaatc ccactccaag aatgcctagt atcgtactta aacttactat gtaattcttt 1717021 gtcatcgttt gactgtcaat caatattaga agtgaaatca atccagctaa aacacctata 1717081 aaccaagcat cgccaacagc ataagaatca tccagcatcc ctaaccatcg ccccaatata 1717141 gagctcccaa tggcagtcaa actggataaa aatatgagtg ctttcatttc ttctcctcct 1717201 ttaaagccaa tcaaactggt agaaatcggc cattgaatcc ccattatcga atggttacca 1717261 tttcatttcc acattaacat tttaaagctc attacaatac gattcaagca gaaaaaccct 1717321 acataacgta tatataggga tttaataaaa cacaggccaa aattcagctc tatctacttt 1717381 aaaaagatat gaagggcagc tgtgtgatct gttacgtctt tacgtaccgg gatatttcac 1717441 aacaggcact ttcttcttgc gcagagaatc aagcatgact gatccagcat tcaagttgct 1717501 ttgtactaat tctttaggcg tcaatgccat ccactgattg agtgacacat ctgcatagcg 1717561 gttacttttg aacatttcta aaaaccataa tgtttctgta ccagtgtttt gtatatagtg 1717621 tccggcatta gaaggcacgt atccaacgtc gcctgctcta taatcaaatg tgcgggcagt 1717681 cccatttccg ataaataccg tcattcgtcc ctgtcctgtt agataatatt gccactcatc 1717741 gctattggga tgccaatgaa gctctctcat cgcgccaggc tcaatctgaa caagtgcagc 1717801 ggctatcgtt tttgaaattg ggaagttaga agaatccaca attcgtacac tcccccctgg 1717861 catttgaatt gggggttgat ttaacagctc gtgtttaaag gtcatgggga cttttccata 1717921 tggtgactga atgtcttcac tggcgactga tcccggcaca ttcccttggt agatatagac 1717981 ttgctcagac ggaagagagt tgaaagcatt ctccgggaca ccgaaatttg cagacagaac 1718041 atcttttggt gtgtgtgcaa gccaatctga aatggttaac gttgaaaact cagaaaagtt 1718101 cccatcatcg aaaacgagca gaaactcgca gtgttccaat ccctgtatgg aatgcggaat 1718161 tcctgccggg aagtaccaaa ggtcgccggg accaacatca gcaatgaaat ttcgtccgtc 1718221 ttggtcaaca gcggtgatac gtgcccgtcc caaaagcata taagcccact ccgcttgctt 1718281 atgccaatga agctcgcgga cgcctcccgc agttaagctc atgtttacac ctgcaatcgc 1718341 agtcgaaatc ggaagctgtc ttacggtgat ttctcttgac cagccgccgt gatctaattt 1718401 catgggagcg tctgagaatg aaaatctcaa gttaggaatc ataccctcat ctgtaacagg 1718461 cggaacaaat atattcggat tttgaatatc ccgtattata tttcgcgggc ctgtatcaat 1718521 agctccagct ccatcacttc gaataggctg cggcacgttt ctgtcttcat gattgattgg 1718581 ttgttgttcc aacagcatgc acctcgtttt agaaatgaac aagattttat ttcagcctat 1718641 gcagaatctt agattgctgt gcctaggaat ccgcaaataa aaaagtgacc accaatgtga 1718701 tcacaaatac atcaaataaa ctatttttta taccatggct tcttatgtaa tttgattgct 1718761 tctgtctgtt ttttctggcc tgtcctccac tccactttta ctaatacatc atgacctatc 1718821 acttcatctt caggcatata atcaaaggtg gaaatatggt cctccatgcg tcccccaccc 1718881 ggcatttcat cacctgtgta ctccgataag tcgtactcat ctacgttatc atcttgatac 1718941 ttttcgccat ctacatacag agtaattctt tcaacaacag tccacttttc ttccttctta 1719001 ctcccctgcc aatatagatt tagaaaataa ttgggtccaa ttgaagtttt gtctgatttt 1719061 tcaaggttag acatccacag tccgcttttc ccgctgccct catatttcac tttgttccct 1719121 gacaccatta caaataatgt gatgatgcag atgatcaaga atccagcaat gatcaatagc 1719181 catttcttaa tattgttctt ttttctcatg tttttcctca ctttcctaac tttttagtag 1719241 gaaaatacga tcaaaatgtt accgaaaaga aaataagaaa gggctaatga tctaacagat 1719301 gactgtctaa acttttgact taaattaaag tgctttctaa agacaagatt aaaacgtata 1719361 acagctctta aatgcatttt ttgtttcatt gagtcaagaa ccttaaaatg gctttttatt 1719421 attaaaaatc aagctagtgt attaagtaac ttttcaaatt tatttatact catgatctcg 1719481 tgagtcacaa atctcccatc aaaaaaaacg ctaaaagttg tccaaatagc tggtgacttt 1719541 tgtgcctctt ctttcgatga taactgaatt gactgaaatt gaaccccttt cttttcagtc 1719601 aattcccgca aatcatttat catgcccact gcaaacggac actgagctgt atagtatatc 1719661 gtaatcccct tttcattgat agaatcactt ttcacctggc tcttaaatgc aggagaatct 1719721 gcaaggccat tccaagtcaa agccattaat tgaaaataag gggcagcttc atcttgtaga 1719781 gtaaacccca tatgctcaaa gaaatgctta tcacttaaat agggcagttt tttcttgcct 1719841 gcgatatgga taatgccatc catgccgcac gctttcgcat ctgctataca tttgtccaac 1719901 aatcgtttcg catgaccgtt atttttatat ctgccagaca cccacagaca attaatgtac 1719961 ataaaattag gcgcattgat aggcacccat gcctcattcg caggtaggta ttcaataaag 1720021 acttttgccc gttcatgtaa gcgatagaac accaatcctt catccattcg agctttgagc 1720081 catctcttct tttcattaac tgcatgctca tattgtttcg tgcttaatgc acagcaaata 1720141 tgattgtctt caatattgtc ctttgtgatt tcaatgtagc acatctcctc tttcccccct 1720201 ttaacataat tacatggaat tcaacttcac actttacatg cctaatagaa taaatacccg 1720261 ttccaactta aatacttttt cttttccatt ttgccaatta actgtaaaac ccttctttta 1720321 ttcagatatt atcttgattc ctatatcacc catttcaaat ccaaagtgtg ttcatctttg 1720381 aggattagat gcactgctta tgctataaat acagtacacg aagtttttta tttgaagtaa 1720441 tatttgttac gggacagcaa tagtaaataa gtgataaaag gggaattaaa cttggtggaa 1720501 aaatgttatt cttgtttaat ttgcggatac aaaggattaa ttcaaaatcc tttgtataaa 1720561 ggcgagtatc aaaaaacgtt tgacatttgt ccatgttgcg gttttgaatt tggctacagt 1720621 gaggatcatg atgtgaggtt aggttttatt gtaactcctg atcatttaat tgaggctgca 1720681 tttcaattgt atcgcaaaca atggcttgag agcgggatgg taattgctca tccggaagat 1720741 attccagaag aattgaaaaa tggcaattgc ttaaaatttg aagttttgtt gaaacaattg 1720801 aaaaaactaa atcttgacat agaaaatttt gaaattagcg gtttttaatg atgaaacagg 1720861 ttgcacttgt ttaggtttca ctgtcattat cagtaaaatg ttaagttgaa atgcgcaatc 1720921 agtcacaaag tctctattcg tattcaataa agactttgtg atcatcgaca aacatttcac 1720981 tcccatcgga taaagtatcc aaaaggcctc ctctggttct tctctatagt cattaatcac 1721041 agtcactttg acatttgact cagctatgat tggttttcca acaatttttc gttttttcct 1721101 caggcaaagt aagagatcga atcatcaaag ccattccatc tttactgtct aattaacgcc 1721161 atcttcagtg aatttaaagg tctgttttaa attgcgtcct tcttgcccct tctgtgtcca 1721221 aattataaca acctctaatt cagaggcctt atctgccagc ataaaatgat tgaacttcag 1721281 cggtgagcca tcatttaaac tttcagctaa cattttagaa tcttcttttg gtttgacaca 1721341 attttcatcg ggacatccaa aaagcgaaaa ccttgtgatt gaattagggt catttctata 1721401 caattgcaca tccactgtag ctgctttttc ccctatattt ttgacttcca aggaatatac 1721461 ttgatattct cctttatgag gtctcgtaaa ttcctttaca ttttttgctt cacttacttt 1721521 tactgaccac tggtctgttt tttgtgtaat aggcaacacc gtaaaagtca gggcatgcgc 1721581 ttttgattgg caaaacgtaa atccaactgc tgtaaaaaca attacagaaa ataataccct 1721641 tttcacttca tttatccctc cttcctttca ctggccgctc cttaaagaat tgattttgag 1721701 caatctacaa gctctcttaa ccaaaacctt acctgaggtt ttgtctttac tgctctgcat 1721761 ttatttcttt cggtatccga gaaggagctt tggggatttt tctcaatctg ctgttaatca 1721821 catcagaaga gtatagcgta ataatcatac ttcccccata cctttttgcc cgaattaaga 1721881 ttggttggtt atattggttt tgaaagcgaa agtcaggacc tccccagctt accgtcgcat 1721941 cccgtccggg cggtacatat ggtacacttc tagtatgaga atagcgctga acgatctgca 1722001 gtcctgcacg atctactgca ttaaatagag ttgaggacac ctgacaaatt cctcctccta 1722061 caccttcaga caactcccct tttacaataa tgggtgcact tttatatcct ttgttccgag 1722121 ttctcattcc cacaacttgg ttaaacgaaa acgtctcatt agggaaaaca acgtgattgt 1722181 cgattgcttt tgcagaaaga gaaatattgt gtgaacggct tttattgctt gagttaaaat 1722241 acgtcacgta ctgaccaagc tgctgcgtac tgatgtgagc tagcagctcg ctgtcaactt 1722301 tcggataaat gttcatttcc ggcacttcta tcttggaggg accttgccca taaaaatacg 1722361 cataaaactt ttccataaac gcctgttgat acagtttgta gccaaccctg cccgggacga 1722421 tgcttccatg atcgttaagg acagcattta tcggctcacg gtacactttc tgatcaagct 1722481 gtttgatgaa tttactgtat ttttcatagt caaccattgg agtgccggga agaggcattg 1722541 taaagtcttc acggttaaca gtggcaatcg tccgtccttg ctgtgtgacc gttaaactgt 1722601 cctgcggctc actcggctga gccaataaaa aaagaccagt gatcaaaatt tgtatcataa 1722661 gtcggtttac ctcccaatca ttagtatgaa cagccgctta tcctttgatg tatttcttcc 1722721 catcgtttgt ttgaatcttt agacgttgat aaaaaccttc ataaaagagc ttagctttat 1722781 gttcacaccg atccctgagc tcactgaggc acacggttca ttcagtcggc aagtttgaag 1722841 tagttcagca tctcccagtg atgagggatg cttttttgtc ttgtcaaaaa tgaaaagggt 1722901 ctcctataac aacaaaaaat caatccattt caatattttt ttattgagaa acgataaatt 1722961 ttttgttaca ttcaattaga caacaaataa atgaggtgct tgttatgaat cgaatgtcga 1723021 caattttttt aaagatagct ttggttctta ttggaattcc aattcttgct ttatgcattt 1723081 ttttagtgcc taaggtagcc aactattcag cagaattatt tccaaatatc gcttatataa 1723141 aatatctcgt tttcatctat ttgtatgtaa cggcgatacc tttttacttt gctctttatc 1723201 aagcgttcaa acttttaagc tatattgaca aaaacaaagc tttctcgggt ttgtctgtaa 1723261 gagctttgaa gaatataaaa tattgcgcag tcactatcag tatcttttac gcagcaggca 1723321 tgcctgtctt ttatctgatg gccgagatag acgacgcccc gggtatcatt gtgatcggat 1723381 tggttattat ttttgcttca atggtgattg cggtctttgc tgctgttctt caaaaactgt 1723441 taaaagaagc gattgatata aaatcagaaa atgacttaac ggtctgaggt gatgacatgg 1723501 cgattattat caacattgat gtgatgcttg ctaagaggaa aatgagcgta acagagcttt 1723561 cagagagagt tggcatcacc atggctaatc tttcgatatt aaaaaacgga aaagcaaagg 1723621 ctattcgatt atcaacttta gaagcgattt gcaaggcttt agaatgtcag cccggggata 1723681 tattggaata ccgaagtgat gaagacacag gattcgtaaa gaaaaaatat gaaggatcaa 1723741 cagaaaaata aagtgattgg cggtgagctt atggacataa acttatatcc atctagctgc 1723801 tatactaagc gtccctttca tacacgaaga acacaactat ggaggaggca tacatcatga 1723861 gagccataaa acaaatcgtc cattttggct gggaacaagc cctttcatgt ttgtttcctg 1723921 ccgttatttt tgcctctttg gctattacgc aaatcatccc actgcccttc ttgccgcggt 1723981 atgactggct gctcattatc tgcgttctca tgcaattgtg gatggtgcgt tccggtcttg 1724041 agacacggga tgaattaaaa gtgatcacat tattccacct tattgggctt gctctggaac 1724101 tttttaaagt ccatatgggc tcctggtctt atccagaaga aggatactcc aaaatatttg 1724161 gagtaccttt gtatagcggc tttatgtacg caagtgtagc cagttatttg tgccaggcat 1724221 ggagaaggct taaggttgaa ctggttaagt ggccgtcttt ttttgcagtt gttccgcttg 1724281 ccgcagcgat ttatttgaat tttttcaccc accatttttc tatagacatt cgatggtggt 1724341 tatcagggct tgtcatcatt gtcttttggc aaacatgggt tacatacgag gtgaatggag 1724401 ctcgttaccg tatgccgctc gcactttctt ttatactcat cggatttttt atatggatag 1724461 cggaaaatat cgctacgttt tttggagctt ggaaatatcc aaaccaaatc gatacatgga 1724521 gtctcgtaca ccttggaaag gtaagttcat ggctcttgct agtgattgtt agctttctta 1724581 tagtagcatc attaaaacaa gttaaggagc agagtcccac aaaggcagag atggatgaat 1724641 ctttttctta gcatacgcat acaagctccc aaatagagtg aaaagcaacg ttcaaatggt 1724701 tgcttttttc ttttatgtaa ctctgccggt gagtattcat cttcttcaaa tttcatcgca 1724761 acacgataac tgattcagat tacaactgct ttcaacactt tgacaaactc atgcgccgcc 1724821 ggcgttatct cttcaaatga atgtgcgatg acgccaatat cgcgtgtgac cctaggaaag 1724881 atgtcctttt taatcaattg atgcgggacg gatgaaagtg taaagtttga aatgatgccg 1724941 atacccaagt tatttttgac catattaatc aaggtttcgg cattttgcac agttaagttt 1725001 tcctttaatt cgatgttgta ttgcgaaaat gcgtttgaca tcgcgatttc atgaccgcct 1725061 ttacaaaaaa tgaggtcatc ttgatatgtt tcaaggtcga catgcttttc aagttttaat 1725121 tcgtcacgct gcggcgggat gacggccacc atatagtcgt tacacaatag ctgattttca 1725181 aacggttcaa atggagatgc tgcgatcccg atatcaaccg tccgatcttc aacccatcct 1725241 tttatttggt cagaggttcc ttcgatcaat tctatgcgga tcagcgggta gtttgatctg 1725301 aatgccgcaa tcgcctgtgg catgatattt gttgaaactg caggaaatga accaattttc 1725361 accttcccgt ttaacagctt gttttcccgg ttggctactt gatatatttt gctttcaatt 1725421 cccttcattt gcctcgccag cagcaatatt tcttttccga tgtcagtcag cattaaacca 1725481 tgatgtttat ccctgatcaa taatttgagc tgcagtgagc tctccaggtt ttttatcgct 1725541 ttacttaccg ccggctgaga gatgaacaat tcttttgccg cttctgtaat atttaatttc 1725601 tccccaactt ttacaaatat gtgaagatgg ttcatgttca taaccatttg gttatacccc 1725661 caataataaa aatgtatttc agttatacat aaatgtaaca tatgatagaa accagcacga 1725721 tattttaaca agaaaggcgg cttcattatg gtaaaagtta tgctgggaat catatctgtc 1725781 acacttattt ggggttatac ttgggttgcg atgaaagtag gaattcatga catccccccg 1725841 cttttatttt cgggtttgcg cctgttcatc ggagcagttc ctttatttct cattctcttc 1725901 atccaaagaa aaaagctttc aattcaaaaa gaacatctca aaagctatat catcatgagc 1725961 ctgttgatgg ggctgggcta tatggggatt ttgacgtatg gaatgcagtt tgtcgattca 1726021 gggaaaacct ctgttttggt atatacaatg cctatatttg ttacggtgat cagccatttt 1726081 tcattaaacg agaaaatgaa tgtgtataaa acgatgggac tggtctgcgg cctcttcgga 1726141 ctgttattta tatttggaaa ggaaatgctc aatatcgatc aaagcgcttt atttggggag 1726201 ctgtgcgtac ttgtggcagc gcttagctgg ggaatcgcga atgtgttcag caagctacaa 1726261 ttcaagcata tcgatattat tcacatgaat gcctggcacc ttatgatggg agccgtcatg 1726321 ttattggtgt tttcctttat atttgaggcg gtcccttcag ccgagtggac atatcaggcg 1726381 gtgtggtcat tgctgtttaa tggcttgctt tccaccggct ttacctttgt cgtatggttt 1726441 tgggtgctca atcaaatcca agcgtcaaaa gcatccatgg cattaatgtt tgttcccgta 1726501 ttggccctat tctttggatg gctgcaattg cacgaacaga tcaccatcaa tattatcctc 1726561 ggcgcactgc tgatatgctg cgggattttt atgaatacat ttacattttc acgacggaaa 1726621 gtgtgaatga tatacatttc ccctgtcatt tgggcttcat gtgacaggag aagactatta 1726681 cgagaaagtc ttctagaatc ctgacgacag cctattaaac aatgaaaaaa gctaatgtct 1726741 gcatgtagac attagcttgg ctggcgttta ggctggtgag aatccagata cttttttatt 1726801 accattctgg ctgatcaaac tgaaaaccgt atagaccttt tactttaaca tctccgcaat 1726861 ctggatcttt tgtcaaaatc aaataatgag tcttataagg catcgtctca actcgatcag 1726921 ttgcactaaa atcaaaatga tcccccgaga agtttttttc actaacggtt atttcatatc 1726981 ctgacaaagt cattcgcatg attcttgcgt taattgtaca tccttcagta tcgaaaatgg 1727041 tgaatctgta cccaaagtga gatgtccaat ggtttgaatt taggtcatca gacttcataa 1727101 accatttttc attctctgtc attgtaaaac tcactttctc ctcatctttc acgataacgg 1727161 ccgaagcttc ccctacatgg atagtcaaag ccaaaagaaa tgtaaaagct aacatcaaca 1727221 tctttttcaa aagagttcct cccgatatct tttacttcaa tatattggaa gggtcttttc 1727281 tgatcaagac agtcttctcc aaatgaatct ttagcaccat gaaatgagcc ttaataagaa 1727341 cagttttaac ccaaatcaac ctctattcga aataaggctt accaatctat attcttttta 1727401 aaagtttctg catttcttta tttagctcct agacacatat aaaaaatgct cctataagtt 1727461 caggagcact acaaaaaact gctaaagtgt tttctatcga tttattgtat tcattagctc 1727521 aaagaaatat tcaggctttt gagtcttatt tagcttatac catgaacgca atgtatctgg 1727581 tgcaaataca tctaattttt tcaatacttc taccgcaaat tccagaggag caattcctga 1727641 tgcagtaacc aaattttcat cagatactgc aggccccttt tcatagaatg tttctccttt 1727701 gtaattaggg cagaccatat tcatatagtc gaggtcattg cttgtgtgct ttctcgaatt 1727761 taagtatcct tcattcgcga ggcccaaggt tgccccacaa attgcagcaa tagtcgtgcc 1727821 gagctttaaa gcgtcgccaa cttttttcaa gatcggctga tgaatatctt ctccccaagt 1727881 gtttcctccg ggtaaaatga taagatcttg actcccaaga gtacattcgt caagagaaat 1727941 atctggtttt atgcttaatc ctcccaacgt agttatcatt tctttattaa cccctactgt 1728001 aactactttt aaagatgctg catcttgttt aaagtatctc cctgagttta gttccgcaat 1728061 taaatatcca tattcccagt ctgacattgt gtgaaatacg tagagataaa cttttctcgt 1728121 ttgcatccaa taacactcca atcacaattg ataaagcttt ctaatagatg actttgctga 1728181 cagtcattgt cagctttttt gttgattcta ttcttatgcc cttgttctcc caacttataa 1728241 aaatataaga tcaattgatt ctatgtttac tagcgcaaag gggtttgtta cactaactgt 1728301 catgggaaac atttcaaagg taatacaaaa tcatttgaat gaggaggcct gatgaagttg 1728361 aaaactaaag cgtcaataaa attcggaata tgtgttgggc ttttatgttt aagcattact 1728421 ggtttcacac cttttttcaa ctcaacacat gccgaagcaa aatccataga agacacaaac 1728481 atggcaagct gtataacgaa taaaaaattt gttcaacttg agaaaaaatt tgatgccagg 1728541 cttggtgttt atgcaattga tataggttca aacaagacaa tcgcctatcg gccgaatgaa 1728601 cgatttgctt acgcatcaac ctataaagtt ctagccgcag ctgctgtcct gaagaaaaac 1728661 tcaattgaaa aacttaatga agtcatccac tacagcaagg acgatcttgt tacatattct 1728721 ccaatcacag agaaacacct agatacaggc atgagcctaa aagaaatctc ggaagcggct 1728781 atccgttaca gcgataatac cgctgggaac atcttgttgc aacagcttgg cggccctaaa 1728841 ggttttgaaa agtcactgaa acagattggg gatcatgtaa cgaaagctaa acgattcgag 1728901 acggatctaa actctgcgat tcctggtgat attcgtgaca ccagcaccgc aaaagcactg 1728961 gcaaccgatc ttaaagcctt cactttagat aacactctca cgactgacaa acgcatgatc 1729021 ttaaccgatt ggatgcgagg caatgctact ggtgacgaac tgattcgggc aggcgctcca 1729081 ataggatggg aagtcggcga taaatccgga gccggaagtt acgggacacg aaacgacatt 1729141 gctatcgttt ggccgccaaa cagagctcct attgttgtgg caattctgtc aaaccgcttt 1729201 acgaaagatg ctaattatga taatgctctt atcgctgagg ctgcaaaagt cgtccttaac 1729261 gatctcaaat aatatgttta gccttttgcc acaaaggaaa agacattact tttttaactt 1729321 ctaccgttca ttttttgatg aacggttctt tcataagacc tctagaatca tatatttaaa 1729381 caccacaaaa ttaaacatta ttataattaa cagcaagttt tcattttatg gaacaagtaa 1729441 agtttgaatc tgacaagaat taagactaag caccctaaaa tccgttttct tttcttccaa 1729501 gaatatactc cttagtgcaa gccattataa agatacaagt gaacatacaa tgcagacaac 1729561 tctcttaagt ctcttattct gtgaccaatt tgtaatactc atgaatatcc ggactcactt 1729621 ccaatatttc gtctcgttcg aagacactaa catatcaaac cacttgaatt aacataactg 1729681 aacttgatat tggtcactgg cagtttcaat gcaatagaac aacatttgtt gtctcagagg 1729741 ttatctatat gagaattcaa caattttttt ataataattc atatttttgt atcgttgcac 1729801 ttggtggatt tgactctttt cgtgtatgga accacacttt tattttttca cctcttttga 1729861 gatcatctgt gttatcaatc tcacttaatc ctacaattac tatgttattt ttaaacttgt 1729921 tcataagttg tccttcagaa agattgtaat cttcttttcc tggagctttt gtatcggtaa 1729981 tgagaattgc cctttcattg tctttaagca cgacatagcc tactaggctc tgcatctttg 1730041 tttcgtctcc gttttgttca tttttattgc agcctgcaag gaaaataatg agcataatga 1730101 gcactatcaa gcttactccg attttaggca tctttcttcc tcctctttaa actcatcttt 1730161 aaaataaaca acaggatatc acccaaccca tctacttctt tttgcaattc ataacagcag 1730221 catactcatt ctccaattcc tcaaccttct ttttattctt tctcaaatat ttgcatgtgg 1730281 tagccctcga tattatccgc ttactcattt ttgcgctttc aaatatatta ttgaaggccg 1730341 cttctttctg gattccagca taaatatact tatccttact gtcgtttact atcgcaactt 1730401 ccattaaaat cgagattttt acttttttta tgatccatta ttcacttcca aaataacttc 1730461 caattacaac ataatatatg tataaattgt aaatggagtt gatgtaattg aagattagga 1730521 aaatcttatt gagttctgct ttatcctttg gcatgctaat atccgcggtt cccgcattgg 1730581 ctgctggcac ttcgtctgag gttgcagtaa aaaatgaaga atatgattat gacactatat 1730641 accgcattag tcctctgcca atggacttcc agccaacaat agaatacaac ggttatactt 1730701 atacgcttac acgtcattat tttgattact caatcgggtt ttacacggct atttatacaa 1730761 aagttgttta aacttataaa ggagcttttt agctcctttt tctcttgttt taagcaaggt 1730821 atttctttct atgtggtccc ctatcaaata caacatcaac attctccagt tctctttgac 1730881 acgaacaaaa tctaaagttt ggttttaaat gctggtaata aaaaattcac tttaaagaag 1730941 tgccgcccgc aaaatacggc ttttgtacac tacgccaatt ttatattgaa aagccagacc 1731001 tcctcaaaga ggttccagct tttcttaatg tgctatcgat cttcgttagt tcaacgggaa 1731061 ctttatcatt cggtacaaat gcagcctccc aacttctagt tagggctgat ggcggaatat 1731121 ctgacggttc tctacacaca tcagacatta gaagatttca atgtagcctt ctgtaccatg 1731181 aacgcgaatt cgttgcccat cttttatcag cttggcagca ttttcaacgc caacaactgc 1731241 aggtaagcca tattcacggg ctataacagc tccatgggtc atcagccccc caacttcggt 1731301 gactaggcct tttatggata caaacaatgg tgtccagctt ggatcggtaa aggaggtaac 1731361 taatatatct ccatcttcta aatccgcatc ttccatgttt aaaatgacac gcgctcgccc 1731421 ctctataact ccggaggaaa caggtagacc tacaatcgct ccggctggga gattttctcg 1731481 tttatactca cctgtaacga tttcaccatc agacgtgata acacgtggtg gagatagttt 1731541 ttcatataat gtgtactcgt cttttcgtgt actgatgatt tgataatcca gtttatgtgt 1731601 gcgcacgact tcgtgaagtt cttcaaaagt gagatagtat atatcttctt tttcatgaat 1731661 aacgcccgct tctatgagtt gttcggcttc tttcagtaaa gcctgcttat aaacgaagta 1731721 tcgattaacc atgccgtatt ttggatattc cctaaacccg ctgaaattcc ggatgatatc 1731781 tatcgctcgt tttgtttctt tggctttttg ttcaccatcc ggtaattgct tcaatcgatc 1731841 taataactct tgttctttct tcaaagcttc ctgtcgccct tgctcaaatt tccgatggcc 1731901 gacattaggc tcaaaatttt taatattatt aagaatcatt gggacaagtg tagttggttt 1731961 ttcgctccat cgagttcttg tgatatcaat ctctccggta catcgcattc cgtatttgct 1732021 gagataatca tagatcgcgt ctcgggtttt gcttccgcca tcaaacttag ccagttcatc 1732081 caaaaagtta tcatctttta catgttgtaa gtaatcaatt acctctggat aaggacgaat 1732141 cacatctgcg acgtctaata gcgcaagacc catttctgaa gtaatattat ggggtacaga 1732201 ttgagaaagc gtatctgctg cgtttttttc acctaaccac tcgttcattt tttcgttaat 1732261 ccataatgaa gcattcatag cagttcgaat tagaaccgaa ctttttgggt taaataaaat 1732321 cttctttaat tcctgaatat cttccagaat aaaacgaaat aaatctgatc ctgatttcgt 1732381 ttggatgttt tgttttaact cttctatcga tgtttgactg ctctcaatca aatcagacac 1732441 gattgtcgga tcgttttcaa cttgagccgg catatctgca ttgcctctgc tgggatttgg 1732501 tgctgtttta tcatttggta tcgactttat gaaatctcgt cgctttatta tggtcataag 1732561 tgcgtctttt aagagctgat cgtgctgccc catgcctttt aagaaaactt ctctgctgtc 1732621 aggggatgcc agatgatgtg tgacatcaac aaatagcctt ccaccggctt tacgcatggg 1732681 tgcaacagtc gtcaacagaa aaaaagacaa tcccagtggt tttatgggat ccgtcatcat 1732741 ttgttgatga ccaacagaaa tatagacgtg attttcttgg tcactcgctt cagggatggg 1732801 gaataaagta gtgattggac gactctgtac aatataaaaa gtatcgcggg ccaaacacca 1732861 ttcgatatct tgcggctggc cgaaatgagc ttcgatctgt cttccaatgc gtgccagctg 1732921 taaaatttgt tcatcagtca gtgtttgagc cttttgctga tcagaatcga tctgctgtgt 1732981 ttctgttccg ccttcttttc gtccgtagat agccattttt ttagttgcta ttctcttatc 1733041 gatgatttgc ccatcctgta ctttaaaaca atcggcagat accaagccag aaaccagtgc 1733101 ttcaccaagt ccaaaaccgg catcgatgga taacaccttt cggttggagg taatcggatc 1733161 agcggtaaat aaaatccccg aagcctgagg gaaaaccatc ctttgaacga taacggataa 1733221 atagacttgg ctgtggtcaa atccattttg catacggtaa ataaccgcgc gatccgtaaa 1733281 tagggacgcc cagcatttac tgatatgctg caagattgca tcgacgccgg taatatttaa 1733341 ataggtgtct tgttgaccgg caaaagaagc atgtggtaaa tcctcagcag tcgcactaga 1733401 acgcacggca taggcatgtt cctcgccaaa ctgggagaga tattgagcca ctgctttcac 1733461 aacatcggaa ggaatgtcta cttccataat gatttgccga atcttccggc tgatgttacc 1733521 aatctgatct cggtcctcaa cttttagcat ggtcaattga tccaacaaca cttgtaacgt 1733581 ttcgttttgt tcgatggctt tttgatatcc tactgttgtg acacaaaatc cttctggtac 1733641 ttgtatacct tgaatttttg ataattcccc taaatgtaac ccttttcctc caacgagcga 1733701 aagctgtgtt ttttcaattt catgtaaacc gagaaccaaa gaactcattc tacatctccc 1733761 cttcaaaaaa aaatattgac aagagcttcc tagcaggata taataaaatt ataagatgga 1733821 tatctataac tttttaacta gaaagcgcac gtagtgtgat tatatcaccg tgtctgtttt 1733881 tgtgcaatat aaaaagaacc tgggaaattt caccaggttc ttttcttaat ttccatagct 1733941 agtcgcatta aaaaacttgg tttgagctga ttcaatcctc taaggaaatc ctaaagttgg 1734001 gttctttttg aacttacttg ctttgttcgt agagtcccca ttcataaatt ggactttttg 1734061 ttcttaacag tcccaccttt aactagtata aagttatgag gatctggtta actactagat 1734121 atttttattt tgaataaggc ttatgtttga taaagaaggg ttatgtaaag gtgtctgttg 1734181 tgagcaagcg ctgactacaa aaaattgata gcattctcat ttaaatacca ttctattaac 1734241 ctatagggaa agttttaaaa ccagatggag aataccctac ctccagcaat tccaaggccg 1734301 ttcacctagt agaaaacaac ctttaaccat tactaacgat tttaataatc attgattata 1734361 aaacttctca aggaacgatc agcagcccgt tagctacccc tgattaagga tgatctgtta 1734421 ccacactgtt acgttagaac ttccactact ttgatatcct tctgtcgcca tgacttggta 1734481 agcccaatta ctgcccagat tcattccatg gctcttccat gcgttcacat gattgctgaa 1734541 agtgattgta gcgttgcttc cggttggtct cttcgactgg cgaacactcc agtactgcgt 1734601 aaaagtagtg cgatcgccat caatggaagg tgcgttataa cgtgtagttg tatatatgtc 1734661 atatgtaccc ccatcacttt ttacagtacc tttatacgtt ccagtaggtc tataagtacc 1734721 ccatgaatcc actacataat attctatgag aggtgatctc gtccaaccat ataaagttaa 1734781 atatccattg ccattcggcg cccaaactcc ggcattatag tttatcgtcc taaatggcga 1734841 acctgtagtc caacctttac caacaacaaa atttccggta ttagaccaat taacactgta 1734901 attcccgcca gacccattga cagcgtttac tataccgccc ccatcagtcc aattttgcca 1734961 gtagtctgtg ctagctgcag aggcggttgc cgaaaacaag ctaatactca ttaaagctgc 1735021 cgataatcca actaagaaat tctttttaaa cttaaacata tgttacctcc tataatattt 1735081 tttccgactt tgaggtagca ctcgtataca tttaaaacat tcttaattac taacgccaaa 1735141 gcttttgatc gtccccttca gtataatacc acgaattcat gagcaaatat taaaagtatt 1735201 tgtaattcaa ttacaaatac ctagaaacac attataagtg gtcttcttcc accatatcct 1735261 gatccgagct cgatgtacat gcctttacgg cacacacgaa tgtggcgtgt ggtgcatcgc 1735321 ctcaatacgc aaagacgttt gccttaggca aacgtctttt tttgcgttat ccgatttttg 1735381 tgccgtttgg gacaggctga tccggctgca aaaggacgac gtcgccctgg ccgggtatgc 1735441 cgccgaggac caagacttcc gatttaaatc cggcgatccg gcggggcgga aagttcacga 1735501 ctgctatgac ttgcttgttg atgagacctt ccggcttgta acgcttcgtg atttgtgcgc 1735561 tcgattgttt tatgccgatt tcagtcccaa aatctatcac aagcttgatt gccggtactc 1735621 ttgcttcagg aaattcttcc gcttttacaa ttgttcccgt tctgatatcc aatttctcaa 1735681 agtcatcaat aactgccata tcaataactc ctttttctcc tattgtaaag gagatataca 1735741 atattctttt aactaaagag ccatcatttt ttatccgaat ataaggtgtt tcgatacagg 1735801 cggggcggca ttcctgtgct tttcgtgaac catcttgtaa aagaagaaag gttttgaaag 1735861 cccagcgcct cgctcacgac ggtaagagtt tcatttctct ccatcagcat tctttttgct 1735921 tcctcaaggc gaaggtcggc aatatagttc tgcggggact tccctgtctg ttttttgaac 1735981 cagcttgaat agtaagctgg gtgataatgc tcgatttctg ccagcttctt aatcgtcagc 1736041 cgctcaaata aatggctgtg aatgtatgca attgaggcat agctatggga ttgaagcttt 1736101 tcttttatgt attgtactag catatgaagc gagttggctg ttccggcctt tgcttcctct 1736161 gtcagcaagt acctgatcga agaccagaaa ggatcgaggg cagcttcaat tcctgatcct 1736221 gcacgatact catcaatttt cattgcatga agcggaacat ccagtacaag acattcattt 1736281 cttccgatag aacggaagcg atgctcgcac tgcggcggaa tatataaaaa atgatccgga 1736341 tttaatttca cctggcgccc ctcagtctca agatcaatac tcccttcaag cggaaaaaga 1736401 aattggctgt acgcgtgctt atgtgaatga tatagccgtg tgtatgtccg tttttcgcaa 1736461 attatctctt gaagcgagtc cattagcaaa ccccttcctt tggtcatctt ttaatccggt 1736521 aatggtgttc cgatataggc gaaaagccga tttttccata taaagaaact gccgccagat 1736581 tttctttcat cacttgtaaa aacatgcgtt ccgctccgtt gttttttgcc cattcagtca 1736641 acaccctgat cacttgggtt cctgcccctt ttcctctgtg ctcctcagct acaacgatat 1736701 tactaagtcc gccataacca tcaatgacag aaaccgtgcc aagcgctgtc aggctttctt 1736761 tgtcatacat cttgaaaaaa gttttacacg gcggcatgcg ttcgaatatg tgtttgtaac 1736821 ctttgtgacg ctcgggtgaa aacccttcta attgaataaa ttcatctatc caaacagatg 1736881 atggctcttg ttcccacttg tatgtaaatc ggctgttgtc atttgttcgg ctcataattg 1736941 accggcacaa cgctgtcatc tggaagcact cgtctacctt ttcataacgg ctgtctgcca 1737001 atgcgtcatc aagccctttc ggtgatgcgt tgctaatatg aaaacaaaca ggtaagccta 1737061 aactttgata aaaaagttcg gcctctagct gaaaatcccc ttcaggcata tccgcagacg 1737121 tccatacgct atttgccctt ttggttacgc caaaattcgc tctgagaagc catttcccta 1737181 tgcttttttg aaaataagcc ggccatgaag ctgccgctaa tcgttcaatc ttgcgaatgt 1737241 catccattgc ataatgcctc tcccctatgt atactccctt gatattatac aatattcaga 1737301 aatataagac atccatttat ttgtttacat aatattttta ttgtttatta ataatcctga 1737361 caaaaatgtc cgaattgaaa atgacaggct ttctaaaatg tcctcctcac gttcaaatgc 1737421 ttcttttgcg attaaaacag taaagccatg cagcagactt ctgagccccc ttgtcgcatg 1737481 aatggcagtc ttttcacttg catagccgtt ttcaatgagc agcttcgtca caagacagac 1737541 aatttggtca gagacgattt ccgtccgttt gtcgtgaacc ttaagaagag ccgcttcata 1737601 atatccggga ttttcaattg caaaatcaac atatgcatga gctaaagaaa gcatcgcgga 1737661 atctcccttt cgttcggtta cggagtccgc catttgatca aaaagctttg tcagtcctct 1737721 gacagcaagt tctgctctga tcgcttgcag cccgttgata tggttataca atgacggggg 1737781 gcgaacattc atttttttag aaagtgcagc aagtgagaca ccatttaccc cttcctgatc 1737841 ggcaatctct gctgcagcgt ctacaatcat tttttgggtc aaacctattc tcggtgacat 1737901 gctcatcatc ctttctttgc tttttggatc gcctgtctca tccgctctga aggtgatcgc 1737961 aggaattttc catgtccgac agcgagacag gaaggcgcct tatcggcgag caattgtgca 1738021 cttttgatgg cctcctcctt attccatgtg gcgaaagcgg gaaaaggaaa cgcccatttt 1738081 atctgacctg atacagcgat tcctccgcgc aactgaaacg catctcctgc tattaaagtg 1738141 ccgtttcttg tatcaagaaa tgacatgctg cccggtgtat ggcccggtgt tggaatggca 1738201 agcagagaac caattgtttc accgcccgtc agcagttggt gaggctttgt ttgtatgtgt 1738261 ttcggaatac ctccttttat aggcgtctgc ggctcatctt gccgcaaaga tgtgtcacct 1738321 tggagcaaga atgaatcccg ttccgagatc atgacctttg catgcggaaa tgtttgtgcc 1738381 aatgtatcca gtgatccgac atggtcccca tgtgcatgag tcagtaaaat atgctgaagc 1738441 ggttttccaa gctgattcac agcttgaata atccctttat agctgcctgg cagtgcggca 1738501 tcaataaggg tgacttcgtt ttcttcctct actaaatagc aattaaccgg aaacaatgct 1738561 ggaaaaaaag tcagctgcca aaccgtttgg tactgagtaa ttctcatctt tttattcctc 1738621 ctaacaaaaa ctaatggtgt tagttttatt attaactaac accattagtt tttcaagagt 1738681 ttattatttt tttatcgcta cataaatgtt aacttgtgct cgctgtggca ctgcggcatt 1738741 ttgatcatac atctcaaagt cacctgtaaa cgtgcgcaga tgccgcttat cccaagtcca 1738801 aatttccttc cacgtttcaa gcacaatctc ttcaatagga ccgattctgg aagtgaaaac 1738861 ggcgtaagcg gaagccggca aatcaatatt ttcatatggt cccggaagaa tgtcgtcgta 1738921 ttcctgaaac gttccgactg aaaacgtata aaacccattc gtctcttgtt cataattcga 1738981 atataaggca ataatgctct tgtctttttc agcctgtgat aaaagagcgc tcatatcctg 1739041 cttccataat tgatcccaca gtgccggaat cctcctttct tccgtcattt ccagtgcgtt 1739101 gcttgtccgt tgtgatagtc cggcaaatcg tttcaggtct aagtgtgtta tatgtgaaaa 1739161 gcccatacga tctcctcctt tttttaagat tatagacaaa gaaacctgac agcagtgtgt 1739221 caggtttcat atattttttg catgtgatga atggtttctt ttactttatc ccttatatga 1739281 agaggctgca gaacctcaat atcctttccg aactggagca aaaaaccgat cagccattga 1739341 tcttctggaa gtgaaatcac cgcctggcag atttcatctt cctcacaaca gtgaaggaca 1739401 tcatatccga accattcacc tatacgctga cgtgctgacg gctgaacaag aataaccaat 1739461 tcagttaaac ggtccttttg gtaccaactc ttatcccatg gcaaagtgtc cagctgaatg 1739521 tcttttctga taaatgtctg atgtaagatg gccagatctt tcatccggtt cagtttaaaa 1739581 aagcgaaaat catttcttac caggcagtag gcatataaat accagtgccc cgccttgcaa 1739641 accaatgtat aaggttcagt ttcccgaagt agtgtttccc cgcttgcgct tgtatatgta 1739701 aaagatatcg ttaacaaccg atcgatggca gcgctgattt tctcgcgcag cgtcttttga 1739761 tcctcagtat ggccccaagc cgtcatgtca ataaaccatt tttctgtttg gtgcttaaat 1739821 gcttgagtag attgctcagg tataaggtgt ttgatttttt gataggctgt gctgtgagaa 1739881 acgggttcat acatagatga aacgctttgc aaagcggaag caattgcaaa caattcctcc 1739941 tccttcagcc actctctttc aagccgatac gtttccatga tgccaattcc gcccccggaa 1740001 ccctgtgagg tcacaatcgg aataccagcc ctattgatcg tctcaatatc acggtaaatt 1740061 gttctgacag atacttcaaa cagctcagca agctctgcag cctgcacttg ttttttgctg 1740121 atcaataaca caaccatcgc taacaaacgt tccagtttca ttctgcgcac cttttcttct 1740181 tgtattttcc aacaaaacaa tcataacatt ttgataaagc ttgggcatat ctattatgcg 1740241 gcggaataca cctcgcatat gctatgaaaa caggggtttc cccttctttt ttgtgttcag 1740301 tatttatttc agctactatt tccgaccgga taagcataca cttctcaacg gaggggattt 1740361 cacatcatgc atcttacact tcagagcgtt tatcctgcca taatcatcat cttttttctg 1740421 tataaaaaaa ttaaaaggtc catcggatac cagccgctga agccccgctg gctgttcacc 1740481 cgtatcattc ttttctcgct gtttgctttt ggactttcaa tcttcagcgc cattcaccct 1740541 tttttatatg gatatctcat tttgggcatt cttggcggat ggctccttgt ctttttcgct 1740601 aagaaaaaca tctcttttga aaaacgcaga ggaaagatct attttcggac tcatatttgg 1740661 gtagaggtga ttctcttaac tttatttcta tcaagatttc tgtatcgagt gacggagctt 1740721 tatcttacct cacctgatct aaaccgcctt ggatcataca gtcagtcaat cggaacggac 1740781 cctctgacaa ttggcgtctg ttttctgata gccgtttatt atatcggttt ttcttctttt 1740841 atcatcaagc tcagcagaaa cgaacttgaa cagcacgaat acaataaaga aaaagacatc 1740901 cttgcccgct aacagcgagt taagcaagga tgtctttttc aatcatgctg tgtatgatgg 1740961 atcatttgct gaagaacatc taaaacatgt tcatcctccg gagagtaata aatcgatgtt 1741021 ccttctctgc gcgatttgac aagccggaga ttttttaaaa atctaagctg gtgggacaca 1741081 gtggattgca gtaaattcag cttttctgca attccgttta ctgcatgctc accttgggac 1741141 aataaatgga gaattctgat tcgggtagga tctgaaagcg ctttgaatgt ttgcgcgact 1741201 agaaacagcg tctcctcgtc cagatcagca gccgattgtt ccgtttctct aaattcagtc 1741261 atatgtatca cctttcttta ttcatagttt tatcttataa caaatgcgct tgagtgcaaa 1741321 ccagcctgct tgtattccat ttcaatctca tagtttaaat ttatgtttca aatcaggttt 1741381 ttacttggtc tgatataccc tcttatgtca taataaaaaa ggtcatactg ctccaaacat 1741441 tgagggtgaa acacagtgaa gaaaaagaga aaaggctgtt tcgctgctgc gggttttatg 1741501 atgatttttg tctttgtcat cgcctctttt ttattggtcc tgcttttttt caaccgggat 1741561 ttaatcaaaa aacttccgat cgatacgaaa acgattgttt tggaacgttt aaccgattac 1741621 aaacccttgg tggaagaaga gcttgaaagc caaggactct ctaattatac atcactcata 1741681 ttaggcatga tgtatcagga gtcaaaagga aaaggcaatg atcccatgca gtcctctgaa 1741741 tctctggggt taaaacgcaa tgagataaca gaccctcaac tcagtgttaa acaaggcatc 1741801 aagcaattta ccctcatgta caagaccggt aaggaaaaag gcgtggattt ggataccatt 1741861 attcaaagct acaacatggg ggcaggttac attgattttg tagctgaaca tggaggaacg 1741921 catactgagg aattggcaaa acaatactcc gagcagcaag tcaaaaaaaa tcctgatctg 1741981 tatacttgcg ggggaaatgc gaaaaatttc cgctatccgt attgctacgg tgattatacg 1742041 tatgcagaaa aagtaaaaga aaaaacaaaa actgttgaag aatctttgca ggttgcaaca 1742101 cttgaaacca tggaatccaa ggctcatgaa taagagtcta tcaatttact gacaaaagcc 1742161 caaaaatgaa tttgggcttt tgccatgttt acacgtaaaa aaagccatac tgagtatggc 1742221 ttttaataat acggtgaaat catcaaatat acaataacgc ctgtaaggct tacatacagc 1742281 catagaggca ttgtccatct cgcaattttt ttatggcgct ccacctgcat gctgaagcct 1742341 ctgatcagcg taaacagcgc aagcggcaca ataattgcag aaaggcagat atgtgtaatt 1742401 aaaataaaga aataaatcgg gcgcataata ccttctccgc catagagcgt gttttccgca 1742461 atcgagtggt acgtcacata gcaaatcaaa aatagtaatg ttgttgtgaa cgcagccaaa 1742521 ataaagcgtt tgtgagcttt gatatttttc tgtttaatca taatcagcgc ggccaataag 1742581 aagataaacg taaagctatt gaatatcgca ttcagcattg gcaaaatgtg aatattcgca 1742641 tggctgaact gatctaattt aggcataaaa aacagcactg cgattaaacc gttaatcaga 1742701 actgtcagcg taaggacaat ccccgtgtaa tttttcggtt tattttctgt ttggttcatt 1742761 tggtgacctc tcctaatttg tactggctat ccaaatcgta tgcaaattca aagaagatgt 1742821 caacggtttc gattgcttcg tcagaaatta gacacacttc aaaggccgga ggctattagc 1742881 cccggcctgt taggtttacg cctcttttat caaatgttca atgaccttat gttcattttc 1742941 attcagcagg ttcttttgaa ttttcgaatg aatgggttta ttcatatgct gatccaagat 1743001 atcggccgtt tctttatccc cggcaataac cattcgttcc catcttttcg cggcagcttt 1743061 ttgatcaagg ctggcagcca gccgcttata cagtctcgat tggttctctg ttacatgttc 1743121 cctcatccgg ttctcttcaa atggtggcgc tttgtctaca gcggaatggc tattcttcca 1743181 agactcattg atcatatcat actcataacg ctccaccgcc tcaatttttc ctaaaacagt 1743241 ttcaataatt ttcacttcat gctgctgagt taaaataaac gccgtacttg ggtatgtctg 1743301 gcgcaaaccc tttagctgat ccaggacagc tgtttcttcc cagtaaaatc ttgtatctac 1743361 agggacttga agcttaatag gttcccatat gccgctgtcg gaaacaaaaa acacgagact 1743421 gcggggcatg tcttttccca ttgcattcaa gtattgattc attttagccc tgattccatc 1743481 cagacacttt tcctcctctg gatcactagc tgccaaatac tcttttaatc ggctgaatcc 1743541 tgactttagg gcaatcttcc attctccccc ctgctgctct ggatctctca tgtctgtatt 1743601 gagatacaga gagagaattt tatccggcgg ttccaattgg acatactgta atttgttaat 1743661 caatgaatca atcgccattc cgattcctcc tttttcacag gttagttttc tttttcctct 1743721 cttaaaaacg atcaaacctg actttccgct aatttctagt aataatggaa ttgttgttta 1743781 caatacgcct ctcttctaat acaattggta actgtgtttc taagctgttt tttgaaagga 1743841 gtttgatctt gtttactgtt aaagaaaaaa atcgtcaaga gcttgaggaa gaactaaatg 1743901 atttagaatt tcaaatttat cgcatgcagg agaatatgaa ggatttatct aaagatgcca 1743961 aagtgcttgg tattgatcaa tcgaaacatg atgagtggat gattgtttcc tcgattgatg 1744021 atggccaaac atgcaaaatt atgctaactg attgtaaaac ggcataccga ggaaaaggct 1744081 gtttttcact tgtagcgtct tacaaggacg atgccattca tataggggat ataaaaggcc 1744141 ctccgaatca cgggtttggc tccatttgca tgaaatattt aaaagatatt gcaagagacc 1744201 ataatatacc gaaagtcacc ggagacatcg ccaaacggga ttggaatcat gtagaccggc 1744261 tgattcactt ttatgaaaaa catcacttca aagtatgtat cgatcatgat acccaatccg 1744321 gcagcattaa gtgggttgat ttgtaaaaaa gtctggaaga aagagccaag atatgctgta 1744381 atggtataaa accattgatg gagggttcta tgtacgcctc aaaactgaaa aagggagacg 1744441 aaatccggat cgtgtctccc gcgaccagca tgtctatatt atcaaatgaa gcaaaaatcc 1744501 aagcaaaaac ggcgttagaa cgcttaggtt atcgggtaac catcgctgaa cacgcaaatg 1744561 aatgtaacga atttgattca tcctctatcg agtcaagagt ccatgatctg cacgctgcct 1744621 tttttgatcc aggcgtcaaa gcgattttaa cgacactcgg agggtttaat tcaaatcagc 1744681 tgctgcgtta tcttgattac gagaaaatca aacgacatcc aaaaattctg tgcggttatt 1744741 ccgatataac cgctctttgc aacgctattt atcaaaaaac gggtcttgtt acgtattcag 1744801 gtccccactt ctcaacattt gcaatgaaaa aaggactcga ttatacagag gagtattttc 1744861 tttcttgctg cgcttcagac gatccgtttg aaattcaccc ctcaagtgag tggagcgatg 1744921 atcgctggtt tttggatcaa gaaaacaggc gtttttatcc taataacggc cctgttgtaa 1744981 tccaagaagg ttatgcggaa ggtactttaa ttggcggaaa cttatgcacg cttaatttgc 1745041 tgcagggaac ggagtatttt cccgaaacag aacatactat tttattgatt gaagatgatt 1745101 atatgtcaga catccatatg tttgaccgcg atctgcaatc actcatccac ctccccgctt 1745161 tttcacatgt aaaggcgatt ttgatcggca gatttcagaa agcatcaaac gtatcaatag 1745221 atcttgtaaa agccatgatc gaaacaaaaa aagaattatc cggcatcccg atcatcgcaa 1745281 atataaatgc cggacatacc tcgccaattg ccacgttccc tataggagga acatgcagga 1745341 ttgaagctat ttcgggtaca tcacgaatat ggattgataa acattaatca gcttgtaaat 1745401 ttttttacaa gcttttttag cgcaatcggc tatgcatgcc gcacgagaca tgacaaatgt 1745461 catataggag gcatgatgtg tgctactaca aaagacttct ctcattagcg tatactgaac 1745521 cgagacacac aatgagagga tacttactat gactgaacaa accattgcac ataaacaaaa 1745581 acagctgaca aagcaagtcg ctgcatttgc tcagcctgaa acaaaaaaca gcctgattca 1745641 gcttttaaac acgtttatcc cattcttcgg cctatggttt cttgcttatc tcagcctcga 1745701 tgtctcctat cttcttacgt tagcattaac ggtgattgcc gcaggttttc tgacaagaat 1745761 ttttatcatc ttccatgact gctgccatca atcttttttc aaacaaaaac gctataacca 1745821 cattctcggt tttctgacag gtgtcctgac tttattcccg tatcttcaat ggcagcacag 1745881 ccattcgatt catcatgcaa ctagcagcaa tctggataaa cgcggaacag gagacatctg 1745941 gatgttaaca gtaaacgaat ataaagctgc atccagacga acaaagcttg catacagact 1746001 ttatagaaac ccgtttatca tgtttattct cggaccgatt tatgtttttc tgatcacgaa 1746061 ccgttttaac aaaaaaggcg caagacgcaa ggaacgtgta aacacatacc ttacgaatct 1746121 ggcaattgtc gcgttggctg ccgcttgctg tctgatcttt ggctggcaat cgtttttact 1746181 ggtgcaaggc ccgatatttc tgatttcagg ttcaatcggt gtttggctgt tttatgtgca 1746241 gcataccttt gaagattctt attttgaagc ggatgaaaac tggagctacg ttcaggctgc 1746301 tgttgaaggc agctcatttt ataaactccc gaaactgctt caatggctaa caggcaatat 1746361 tggttaccac cacgttcatc atttgagtcc aaaggtgcct aactataagc ttgaagttgc 1746421 tcatgaacat cacgaaccat taaaaaacgt accgacaatc accttaaaaa caagcctgca 1746481 atcacttgcg ttccgtctat gggatgaaga taacaaacag tttgtgtcat ttcgggctat 1746541 aaaacatata cctgtaagcc ttccgcctga ttcaccagaa aaacagaagc tgcggaagaa 1746601 tgcctgatga taaaggaggt cttctaatat actagaaggc ttccttttta ttgttggagg 1746661 gtgcattctg gctttcacaa tgataaagtt acaagtaaga tgaaaagctg aaaatgaggt 1746721 aagatcatga ttaaaaatca ttttacattt caaaaactaa acgggattac gccctatata 1746781 tggacgatat ttttcatcct ccccttctac tttatatgga aatcatcatc tacatttgtt 1746841 attattgtcg gcatcatttt gacgctttta tttttttcgg tatatcgatt tgcttttgtc 1746901 tcaaaaggct ggaccattta tttgtgggga tttttattaa ttggcatttc aaccgcctcc 1746961 attactctgt tcagttatat ttattttgct ttctttattg cttattttat tggaaacatt 1747021 aaggaacgcg tcccttttca tattttatat tatgtccatt taataagcgc ggccgtcgca 1747081 gccaatttca gtctcgtatt aaaaaaggaa ttctttctga cacaaattcc ttttgtcgtt 1747141 attaccctca tcagcgcaat tttattgccc ttcagtataa aaagccgcaa ggagcgcgaa 1747201 cgacttgaag aaaagctcga ggatgcaaat gaacggattg cagaactggt aaaattagaa 1747261 gaacgtcagc gaattgcccg cgatctccat gatacgcttg ggcaaaagct ttctcttatt 1747321 ggtttaaaaa gcgacttagc aagaaaattg atatacaaag atcccgaaca agcagctcgt 1747381 gaactgaaaa gtgttcagca aacagcgcga acttctttaa atgaagtaag aaaaatcgtt 1747441 tcctctatga agggcatccg gctcaaggat gaattgatca acatcaaaca aattctcgaa 1747501 gcagctgaca ttatgtttat ctatgaagaa gagaaatggc ccgagaatat ctcattgctg 1747561 aatgaaaaca ttttgagcat gtgcttaaag gaagctgtca caaatgtcgt caaacacagc 1747621 caggctaaaa cttgccgagt tgacattcag cagctctgga aggaagttgt gattacagtg 1747681 tctgacgatg gaacattcaa aggagaagaa aattcctttt caaaaggaca tggcttactc 1747741 gggatgagag aacggcttga gtttgcaaac ggaagccttc acatcgatac cgaaaacggg 1747801 accaagctta ccatggcaat tcctaataat tcaaaataaa cataaaggat ggcttatatg 1747861 attagtatat ttattgcaga agatcagcaa atgctgctgg gcgctttagg atcacttcta 1747921 aacctcgaag acgatatgga agtcgtaggc aaaggtacaa ccggccaaga tgctgttgat 1747981 tttgtcaaaa aacgccagcc tgatgtatgt attatggaca ttgaaatgcc cggaaaaaca 1748041 gggcttgaag ctgctgagga gctaaaagat acaggctgca aaattatcat cttaaccacc 1748101 ttcgccagac ccggttactt tcagagagct attaaagctg gcgttaaagg ctatttgtta 1748161 aaagacagtc cgagtgaaga gctggccaac gccatccgta gcgtcatgaa cggaaaacgc 1748221 atctatgcac ctgaactgat ggaggactta tacagcgaag ctaaccctct tacagataga 1748281 gaaaaagaag tgctcgaact tgtggctgac ggtaaaaaca caaaagaaat cgctcaggaa 1748341 ctcagcatca aaagcgggac ggtgcggaat tatatctcaa tgattctaga aaagcttgaa 1748401 gtgaaaaatc gaattgaagc cattacccgg tcaaaagaaa aaggctggtt taaataaaaa 1748461 aggatcttgg catctgccag gatccttttt gttaacctga aattcccgtt tgagaacctc 1748521 gtcgcaacca gaattaaatt gatccatatc ctcgctccta cgcccgctga acgattgttt 1748581 ggttaacagc ccaataaaag actggattga atgatatccc tgttaaaatg gtcggccatt 1748641 gcacatcagc agaatttctg atattgatta tattgtattt tcagtatgac aaagttgtgc 1748701 cacttcgctc ccgaagctgc catgcccaac tgcaagagcc taatatcaca ataaaaaacc 1748761 gtctgaaatc aatccgattc cgtaaatggt atctgctaca tccaactgct tattatctgc 1748821 caaaaacacc agctcgtttc gctgatcaaa gatagtaaca accagctata aatgtcatga 1748881 tgccgaatgt ctctgtaatg tggaatcaat cttttaaccc gagagcccct gaatcgcaca 1748941 taaagaaaaa cgggaccact ttcttttatc agcatatgat ataaacagct ctaagcagaa 1749001 caaaaaaaga cacaagccaa aagcttatgt cttttatcac aatctatatt attagtttaa 1749061 gactttaaca cttacagttt tgacgcccca attagaagca tcacttttac ttggtacaaa 1749121 tacgtcgatt ttatttcctt taatagcgcc gccagtgtct gctgctgttg cttccccgta 1749181 gccttcaaca tagactttag aacctagcgg aattacatta ggatcaaccg caataacttt 1749241 cgcgttcggg ttcttattta agtcaatgcc tgtagctgta acgccggaaa tgccgccgtc 1749301 gttagcagtg taagcagtag cagtaactgt tagttctttt gaagcttctt gattatttgt 1749361 atttgattga acagccttct cctctgtgtt aacagaagtt tctgcctcag cctttgtttc 1749421 ttgtttaggt tgctgttgta cagcttcttg tttaggttgc tctttttgca cagcctcttg 1749481 ttttggcgca gcttgaggtg cgtttgtttg cgcattctca gtagctgtgt ttgctgctgt 1749541 tgcctgacct tttactgaaa gagttgatcc agcatagatc atgtcagagc ttaagttatt 1749601 ccaaactttc aggttgttga ctgtcgtgcc gaatttttga gcaatcttag aaagcgtatc 1749661 tcccgcttta attgtatatt gcccagtcgt ggttgtttct tctgaagaaa tggtcagttt 1749721 ttctcctgca atgattttat cagaagttaa cttgttccat tcttttaagt cctttaggtt 1749781 cactccattt ttctgagaga ttccccagag cgtatcaccc ttttgcaccg taatttcttt 1749841 tgcagaagcg tgagctccga atgcagttgt tgaaagtgca gcaactgcca caaaggacat 1749901 aatcgtcttc ttcataagta aatcctccct tgttagcttt ttattggcgg ctaacaggtg 1749961 atatcgtaac acacgtaaat gtcaaatcaa taacaaaaag atatgattta gattacagtt 1750021 cctttacatg aaggatttct ctctgatgga aagacttgct gaacccttga tataataggc 1750081 ttcgcaggtc tttttatttt gaggcgaaac agagaaaata aaatgtgttt tttatagaaa 1750141 aaaagattgt ttttctgttt ttttagtctg tcatccttgc ataagcctgt atttcttgta 1750201 aaaaaagccg gccgtatttt gctctttttt gttctccgac tccttttata gacaaaagtt 1750261 catcatcatt tacgggctgt tttcctgaca tttcttttaa cgtttggtca gagaaaacaa 1750321 caaatggcgg aacaccctgc tcagccgcaa tttctttccg aaccatgcgc aatcgttcaa 1750381 atagctcgtc attttcagta atcgctgccg cttttaacgc ttcttttctc gctactgata 1750441 attctccttt cagcacattc cttcctttac tgctgacaaa aagagtcgga aacgttccgt 1750501 ctgacatcct gatgaagtcg tcagaaataa gaaattcgat aaaatcactg atttcgccaa 1750561 cggattggtg ttttaatatc ccgtatgttg aaaggtcgga aaagccgttt tcaagaactt 1750621 ttttattttt ggagccggca agcacctggg caaccatcgt cttgccaaac cgttctttca 1750681 tgcgaatgat acaagataag accatttgcg cctcccgcgt cacgtcatgg gccgctcttg 1750741 tatcggtaca gtttccgcac tgtccgcacg catcaggctc cttttctccg aaatacataa 1750801 ggataaaacg ctgcagacaa tcttccgtat gacagtagtc gaccatttgt ctcagctttt 1750861 ttaaatcctg cttttgtttc tcttcatgtt ctgattgctc aattaagaag cgctgcacca 1750921 taatatcctg cggtgaaaac aggagaacac attcactggc aagaccgtcc cgtccagctc 1750981 gtcctgcctc ttgataatag ctttccatat ctttcgggat ttgtgcatgc agaacaaatc 1751041 tgatatttga tttatcaata cccattccaa aagcagaggt tgccaccatc acttgaagct 1751101 catcattaag aaatctttcc tgctgctctt ttctcacatc atcagccaaa cctccatgat 1751161 accggcctgc cctgacctga tttcgtttca atctctcata tatccgatca gcttcttttc 1751221 tggtcgctgt atagacaatt cctgcttcat gcctgttgtt ttgcacatat tcgtctataa 1751281 accgatcttt attttctcct tttactactt taaaggttaa attctctcgg gaaaatccgg 1751341 tatataccgt gttttctttt tgaatatgca gctgtttgca aatatcatca tgaacctcgg 1751401 gtgtggctgt tgctgttaac gccatgatga caggcttgtc gtgtaattca cggaacaaga 1751461 tttcaatatt cctgtagctt ggcctgaaat catggcccca ttgagaaata caatgcgcct 1751521 cgtctattgc gaccaaagga acatctatgc cctgcaaaat ccggataaac tctatggacg 1751581 ttagtcgctc tggtgtaatg taaaaaagct tataagcccc ttctttgagt ccgttcagcc 1751641 tctcatatat ttcctgattg gattgtgtgc tgttaatgta ggcggcgtta atccccgctt 1751701 cttctaacgc atcaacttga tccttcatca aggaaatcaa cggtgaaatg acgatcgtcg 1751761 tcccttcaaa cattaatgcc ggaatctgat agcaaatcga tttgccgcct cccgtcggca 1751821 taatgcaggc cgtattttgc ctcgcttccg tcaccaagcg gatcgcttca tcttggccgc 1751881 tccgaaactt ctcataacca aaataatgag ccagaaggga ttgggctcta tgtaacataa 1751941 cgtgtaaacc tcgcttttcc ttgaatttct cccatcatat cataaaaaag cggccttcat 1752001 ttctttcaca caaaaatgga atattcacta taccaaacct ttttagataa aataaaaagc 1752061 catttccgaa aaggaaatgg ctttcgctac gtcttgccgt atgcaagtaa gaaagtttta 1752121 aaccaccact cctcaaagtg ggtgtttgca gaaacgttcc tgtcgtcctc tgcaatggag 1752181 gcatgacatt ccggcttcga tataaaactc cctattacag cttaaaggtt aaaacttaat 1752241 taacaatacg cacaaagtag cttctttaat atagtacacc atcaggcgct tttaatcaag 1752301 aggtcagaac aattgtttag aaaaactttt tccagtgaat aaaactgttt tttctccaaa 1752361 atacctgaca attcgacaaa caaaaaatat attacaataa aaaaaatagc ctttattgct 1752421 aaaagcgaat gattattttc ttctatatta atgtgtatat acaaaaagac tcctatttgt 1752481 aacgatagga gtcttggctt tattagaatt ttgcagcaag atcttttgct tcttgtaaac 1752541 ctttttcaac gatttcttgc gcttgatcag gtgctgcgtt atgtccttcg atgacaactg 1752601 tgtgcaagtc ttgaacaccc cagaaaccaa gaactgtttt catgaagttt aatgacattt 1752661 caagtgcagc cattggtcct tctgagtaga caccgccgcg agcgttaaga agcgcaactt 1752721 ttttgccgcc cattaaaccg actggtcctt cttgtgtgta tttgaatgta acgcctgcgc 1752781 gagacagata atcaacataa gtatgaagca ctgctggcac tgtgaagttc caaagcggga 1752841 atgcgaaaac aactttgtca gcttttacaa actggttcag atatttgtca gcaattgctg 1752901 cttgtttttt ctcatcttct gtcatttcca ttccttgacc tgctttaaat gttccgttaa 1752961 tcatatctct gccaaggtaa ggaaggtttt ccttatgaag atctaattca accacttcat 1753021 cattagggtt gttttcttta taagcagcta agaaagcttc gtaaagttta gttgaaacgc 1753081 cttcttcagc tgtacggtcg cttgatttta caaataaaac tgtagacatt tgtattcctc 1753141 ccggtaaact ttttatattt acttacaaat agtatgttac tttctttttt acgtaaagtc 1753201 aatcacttta ttttgaatat gagatttttt ttcaaaaaaa agcaagtaca tctaatatcg 1753261 gtgtacttgc ttggcatttt tacttcgaat cttgttcacg atccaagatt tcatacgtct 1753321 gcgagctttt ttgatcaatt gtttctttgt tggataagtc ttttacctgt tcatgaaact 1753381 ctctttcata agaaggagca tctgtctcca gatcatcctc cacatcagct tgggcctcaa 1753441 ctgtcattct tgcataagga acagcttcaa gtctttcgta aggaatctct tggccggttt 1753501 tttcacacac gccataagtt ccgtctttca tcttttgtaa tgcacggttg acctcctcta 1753561 acagctcccg gtcaatctct ttcactgttt ggtctgtcat ccggtctgtg acgagcgtcc 1753621 cgtggtctgc catatggttg tcaaccccat tggaaagctc ccccacttct tccgtcattg 1753681 attctgtttc ctttttctcg ccagacaatt ctttttgcat atcgagcaat ttatgataga 1753741 gatgctgtgt ttgttctttt gtcagtgcca tgtatatcct ctcctttcta tcctgtttcc 1753801 cgttttgcct tctgtcaaac atggaaacat cgatggaaag atgagctact gcctttttga 1753861 acggatcgtg accgctggcg tcgatggtgc ttcgggtttt cgttggcact ttttgtcctt 1753921 ctcttctggc ggtatataat aggttgcgcc tatatttaat ctgccgctca gttcatcaat 1753981 ggtcagctcg ccgaattcaa gatgatagtc aactttttcg acattcagcg tttcaatatg 1754041 tatataggtt tcttcagact cttgtttgct gctttgtttt tgtttctcaa tcactgagag 1754101 tctttcttca cattcacgca gtttgtcaag ttctggtttc aagcaatgcc tgatcagcga 1754161 ccggaacatt tttttcatga catcacgacc ctttgcatac tcctctttcg tctacatata 1754221 taatgaggta tatcccatag aaaggagagg ttttcatgct tccgactaac atcaatattt 1754281 ctcatctcaa gactaactcg ataggcaccg gctcatccct tacctttggt tctgcggagt 1754341 taaggaacag gtgctctgct atcaaaagaa ataacggttt tggggaacaa aatgcagatg 1754401 gtattgttat ggtcattccg attgaatcaa ttgatgaccg tgatgtgtca gatgcactca 1754461 gtatgaaaat caatcatcaa taacaatggt tttcgcttga ccttcgtctt tttgaatagt 1754521 gatgtatagg attccgtctt taaaaatggc attcatcttt ccatgaagat gatcggaaag 1754581 cggaattttc ttttcaaaac ttccgtattt cccttctttt tggcgaaagt cctgttcatt 1754641 aaaataggaa aagcgctgcc ccttcaccac taaataatct ccgtacgata atatgtgaac 1754701 gtcttgttta cggtagcctg gaagataaat taaaaactgc acttccgcaa cggtatctac 1754761 aatatccatg ctcggaaatg aagcatctcc tttccctcgc tgatcttgct gcgcaaacgg 1754821 aaacggagat tggccatttg tcataaaagg ggttttttgg tcttcatcaa atacctgttt 1754881 ccaaaagtca ccgccgtaca tctgctgtgc gaattccatc cactgcttca tcttttcgaa 1754941 atccatttga agccccctgt cttaacatac tttataaccg ccagcataca actatagaaa 1755001 ggaggtttgc ctgtggttca accaactccg tatatcaata ttaatatttt catgctgaaa 1755061 attaattcct ttgaaaatgc ttcagcggtt aacgtaggac aaaatttatt ggcagaatgg 1755121 caaaattcag ataaaaaaaa tcaaggctac ggacagaatt ttggagatgc gagcggattt 1755181 atgggcacga gaagccatgt ggatgacaga gaccaaattg attctccggc ctcttttgaa 1755241 agtgaagcgg ttaactcctc aatcaaaagg aagtgatgag atgttctttt caccctccgt 1755301 cgtaaatgtc ggcggattta aaatcaatac gatggatcga ggttcctctt taacactcgg 1755361 tccgtatcag caggtcgatt actttttatc agctaaaata aatcaagggt ttggagaaga 1755421 aaatggcgac tttactcctc ttgtcgtgcc gatttcaaat gtattagatg cagatcttgt 1755481 tgattcgaac tcagcgaaaa acagtgtggt gtaataagaa cagggcgcac atgccctgtt 1755541 cttgttttta tatataaaaa aagcctaacc attttttgaa cggctggctc atcaaatatt 1755601 cagctgcaca aatgctttgt cagcaccgcc tgaacctcgc ttaaatcggt gtctttcgca 1755661 aattctaatt cgaaagtttt gcttcttgtc atcaataaaa gcccagtgtc cggatcaaac 1755721 attcccgctt cttggatggc aaagctttca attgttttat atggaagaaa tacacgaacc 1755781 ttctttttag aaaacatttt attgtcaaag aaaatgatcc gcttatttgt aaagcaaatt 1755841 tggtccactc ggagcttata aatcgattca attctttccc cttcaacgag caaagcctca 1755901 agcttctttg cgtccgttga tctgctaaca gaaaaaatac ccaatgaaga acccctcttt 1755961 ctgcatttat ctatttgttt tatcattcac tacataaaaa taagtccttt atccctatat 1756021 aagaatacga catagaagac atttaaacca ttacgaacag attacatttt tcaaattttt 1756081 gatttgtttt ttggctttta agctgttgtc atcaagtaat acgcacatat agagaaaaaa 1756141 gtttcaatat tcagcaatgt ttttataaaa aagtggtttt taatgatttt tttaattttg 1756201 ttttatattt cctgttttaa ccacaaaaaa accgcagctg agctgcggtt ttatgtatcg 1756261 actgctttta acaaaatctg tttgatgctt caaggaagca ttacatctct tcgaagtatt 1756321 ctttataata gccgccgact ttattcgtat tgtcgaccac aaagagaaac tcctctgttt 1756381 cattttttac ttcatattct tttcccggcg ttaaaacgcg gtttacgata tatttttttg 1756441 cgtttgtctg cacacacttt acttttttaa tggtttcttt ttcaagccaa tttttatgaa 1756501 tcatgatgaa atctcctttt cttatctata agcttattgt agcttttttc ttttgtaaat 1756561 tgcaatatcg gttattcatt gattttgcct tgatttctat tatagaatgt ttgtatacgc 1756621 ttacgtttga agcaactatc acagcttatt tctgctattc aatccaggaa tcaatgtgct 1756681 atcaccaaga atctcagaac agaccataaa aaatgactgg aggtttgtta cggatgagtt 1756741 ctttaacgat gcaagtgacg aaaaggctgg agacattttt acagggaaca aagaagcttt 1756801 atattgacgg aaagtttgtt ccgagtgcct caggggcaac ctttgacact ccaaacccgg 1756861 cgaccggcga aaccttgatg acgctgtatg aagcccaggc tgcggatgtg gacaaagctg 1756921 ttaaagctgc ccggaaagcc tttgaccaag gtgaatggag aacaatgtct ccagcttcga 1756981 gaagcagact gatgtataag ctggcagact taatggaaga gcataaaact gagcttgctc 1757041 agcttgaaac acttgataat gggaaaccga tcaatgaaac gactaatgga gatattccgc 1757101 tggctattga gcatatgcgc tattacgccg gctggtgtac aaaaataaca ggacagacga 1757161 ttccggtttc cggcgcttat tttaattata cgcgtcatga gcctgtcggt gtcgtcggcc 1757221 agatcattcc atggaatttc ccgctcctga tggcgatgtg gaaaatgggc gcggcacttg 1757281 caacaggctg tacaatcgtc ctcaaaccgg ctgaacaaac accgctttca gctctttatt 1757341 tggcagaatt aattgaccaa gccggtttcc ctgccggtgt aatcaacatc atcccaggat 1757401 tcggtgaaga tgcgggagaa gcgctgacga accacgaagc ggttgataaa attgccttta 1757461 ccggttccac tgaaatcgga aagaaaatca tgtccaccgc agcgaaaagc attaagcgtg 1757521 tgacattgga gctgggcgga aaatcgccta atattcttct gccggatgcg aatttaaaaa 1757581 aagccatccc gggcgcttta aacggtgtga tgtttaacca gggccaagtc tgctgtgcgg 1757641 gctcacgtgt cttcattcat aaagaccaat atgatgaagt tgttgatgaa atggcatcct 1757701 atgctgagtc actccgccaa ggagcgggac ttcataaaga tactcaaatc gggcctctcg 1757761 taagcaagga acagcatgag cgcgttcttt cctatattca aaaaggaaaa gatgaaggag 1757821 caaaagcagt gaccggcgga agctgtcctt ttgaagcagg atattttgtc gcaccgactg 1757881 tgtttgcgaa tgttgaagac gaaatgacca tcgcaaaaga agaaattttc ggacccgtgc 1757941 tgactgcaat tccgtacgaa acagtcgatg aagttattga acgggcaaac cattcagaat 1758001 atgggcttgc agccggacta tggacagaga acgtcaagca ggctcactat atcgcggacc 1758061 gacttcaagc cggaaccgtt tgggtcaact gctataatgt gtttgacgcg gcgtctccat 1758121 ttggcggtta taaacagtca ggactcggac gagaaatggg atcatatgcc ttggataatt 1758181 acacagaagt caaaagtgta tgggtaaacc ttgaagacta acatgtatgt ttaaaaaact 1758241 gctgcctgcc agcagttttt ttctttctgt aatggcagta aaagacgctg aatatatatg 1758301 cttctgaagg agttgagcgt gatgggcaca cttcaggaga aagtgaggcg ttttcaaaag 1758361 aaaaccatta ccgagttaag agacaggcaa aatgctgatg gttcatggac attttgcttt 1758421 gaaggaccaa tcatgacaaa ttcctttttt attttgctcc ttacctcact agatgaaggc 1758481 gaaaatgaaa aagaactgat atcatccctt gcagccggca ttcatgcaaa acagcagcca 1758541 gacggcacat ttatcaacta tcccgatgaa acgcgcggaa atctaacggc taccgtccaa 1758601 ggatatgtcg ggatgctggc ttcaggatgt tttcacagaa ctgagccgca catgaagaaa 1758661 gctgaacaat ttatcatctc acatggcggt ttgagacatg ttcattttat gacaaaatgg 1758721 atgcttgccg cgaacgggct ttatccttgg cctgctttgt atttaccatt atcactcatg 1758781 gcgctccccc caacattgcc gattcatttc tatcagttca gctcatatgc ccgtattcat 1758841 tttgctccta tggctgtaac actcaatcag cgatttgtcc ttattaaccg caatatttca 1758901 tctcttcacc atctcgatcc gcacatgaca aaaaatcctt tcacttggct tcggtctgat 1758961 gctttcgaag aaagagatct cacgtctatt ttgttacatt ggaaacgcgt ttttcatgca 1759021 ccatttgctt ttcagcagct gggcctacag acagctaaaa cgtatatgct ggaccggatt 1759081 gaaaaagatg gaacattata cagctatgcg agcgcaacca tatatatggt ttacagcctt 1759141 ctgtcacttg gtgtgtcacg ctattctcct attatcagga gggcgattac cggcattaaa 1759201 tcactggtga ctaaatgcaa cgggattcct tatctggaaa actctacttc aactgtttgg 1759261 gatacagctt taataagcta tgcccttcaa aaaaatggtg tgaccgaaac ggatggctct 1759321 gttacaaaag cagccgactt tttgctagaa cgccagcata ccaaaatagc agattggtct 1759381 gtcaaaaatc caaattcagt tcctggcggc tgggggtttt caaacattaa tacaaataac 1759441 cctgactgtg acgacactac agccgtttta aaggcgattc cccgcaatca ttctcctgca 1759501 gcatgggagc ggggggtatc ttggctttta tcgatgcaaa acaatgacgg cggattttct 1759561 gctttcgaaa aaaatgtgaa ccatccactg atccgccttc tgccgcttga atccgccgag 1759621 gacgctgcag ttgacccttc aaccgccgac ctcaccggac gtgtactgca ctttttaggc 1759681 gagaaagttg gcttcacaga aaaacatcaa catattcaac gcgcagtgaa gtggcttttc 1759741 gaacatcagg aacaaaatgg gtcttggtac ggcagatggg gtgtttgcta catttacggc 1759801 acttgggctg ctcttactgg tatgcatgca tgcggggttg accgaaagca tcccggtata 1759861 caaaaggctc tgcgttggct caaatccata caaaatgatg acggaagctg gggagaatcc 1759921 tgcaaaagcg ccgaaatcaa aacatatgta ccgcttcata gaggaaccat tgtacaaacg 1759981 gcctgggctt tagacgcttt gctcacatat gaaaattccg aacatccgtc tgttgtgaaa 1760041 ggcatgcaat accttaccga cagcagttcg catagcgccg atagcctcgc gtatccagca 1760101 gggatcggat tgccgaagca attttatatt cgctatcaca gttatccata tgtattctct 1760161 ttgctggctg tcgggaagta tttagattct attgaaaagg agacagcaaa tgaaacgtga 1760221 atcttatcaa gcggagatgt tcaattggtg tgaagccctg aaagatcaga ttcaaaagcg 1760281 aggtcagctt gaccagtttg aagatcaaat cgacaagatg attgaggctc tggaagatga 1760341 ccaaacaaca gaagaagatt ggtataaaca ggccgctgcc ctttatcggg atattacaga 1760401 atcagatgat acaagtgaaa gacgcgctta tgtccctata gggaaacacg tgctgccaaa 1760461 gcttccttac aaatactccg ccttagaacc ttatatatca cgcgatatta tgatccttca 1760521 tcatacaaaa catcatcaaa gctatgtcga tggcctgaac aaagcagaat cagagcttaa 1760581 aaaagcgaga gcgacaaaga attatgactt aatcactcat tgggaaagag agcttgcgtt 1760641 ccatggagca ggccattatt tgcatagtat tttttggttt tctatgcatc caaacggaaa 1760701 acggcgtcct acaggggcat tgttccaaat gatagacctt tcatttggaa gctattccgc 1760761 ttttaaagaa cattttaccc aggcctctaa aaaagtggaa ggcgtcggct gggccattct 1760821 ggtctgggca cctcgatcag gacggctgga gattttaacg gcagaaaaac accagctctt 1760881 tagccaatgg gatgtgatcc cccttttacc gcttgacgta tgggagcatg cctactattt 1760941 gcaatacaaa aatgaccggg ccagctatgt cgatcactgg tggaatgtcg tggattggcg 1761001 cgaggctgaa aaacgttttg agcaggcaaa agaagtcgtt tggaagctct attaaaaaaa 1761061 gccccctttc ctcgggggct tcgtgtgtta aaaaatacct atcacatgca aaaacacgat 1761121 gatgatggca acaggagata gatatcgaat gagcagcagc caaaccgcaa accactttcg 1761181 tttgagattg gaaccgcttt tcagctcgtc aaacaaatcc tgtttcggta tttttagcgg 1761241 aacaaaaatc gaaatcagta acgcacctaa cggcattaaa atattgctca caagatagtc 1761301 agccgcatca aaaatagaca gatgaaatat agtgacgtca cttaagacac cgtatgataa 1761361 tgcagacggc acaccgacaa taaaaatagc aataccgcct aaccaagcga atcgttttct 1761421 cttattgata tcgcctttcg acagtactgc gaccaaaatt tccagcattg aaaaagcaga 1761481 tgtcaatgca gcaaataaaa atagaagtaa aaatgctaat aaaaagataa ttccgaacgg 1761541 catttgatta aacacagtcg gcagaacgtt aaataacaga accgggcctt ggtctggctt 1761601 gaggccgaat gaaaatacag ctggaaaaat cgcaattccg gccattacag caacaagcat 1761661 gttcataaca gttacagata cagcggactg taccagattt tcctgtttct ctaaataagc 1761721 gctatacgtt accatgacag atacaccgac acttaataag aaaaaggatt gtcccattgc 1761781 atataaaatg gtattggcat caattgcagt taaatcaggc atgaggaaaa atttgattcc 1761841 ttccatcgcg ccatcaagtg taaccgaacg caccattaaa atgatgaata atagaaaaag 1761901 cgccggcatt aatacttggc ttgctttttc aattccgctg cttacccctt ttgcaacaac 1761961 taaaattgtt accaccataa agagcagctg gcctcctaca gccaaataag gatttgaaat 1762021 ggtacttgca aatatcgtat caaaaccaga tgtttgcgat aaaccgccag tgaagccttt 1762081 tataatataa attaaaatcc atccgcctac gacactgtag aaagatagaa gaataaagca 1762141 cgtcaccatg cctaaataac cgatccaatg ccacttcgtt cctggagcaa gtgttttata 1762201 ggactgaacg gcatctttct gtgttcttct gcctatgatg aattcaccta acaataaagg 1762261 cagtccgatt aaaaccgtaa ataaaataaa aataagtaaa aatgcgcctc ctccgctggt 1762321 tccggcaaca tatgggaatt tccatatcgc accaagcccg atagctgatc ctgccgcggc 1762381 taaaataaag ccgagcttcg aagaccattg atttgcttcc ttcaccgtat cactcctatt 1762441 tgatctaacc attataaagg ttcattgtaa gaatatcttc ctatatagtc aagaacattt 1762501 taattagttt acatcatata tctatagaca tctgccaaaa actaatattg aattattcag 1762561 aaaattattt ataataagag aatgttatga aatttgtaag aatttctgct gaagttcttg 1762621 ataagtgtgt taggagtgtt tttatggaca tcattagaaa aataagccat tttgcaggac 1762681 aaacctttgg catatgggtc attgtttttg cagtgctggg attttctttc ccatctttat 1762741 ttacgtggat cagttcttat attacgattt ttctcggcat tatcatgttt gggatgggcc 1762801 ttacactgca agccgatgat ttcaaagagc tggtcagaaa gccttggcaa gttattattg 1762861 gagtaatagc tcagtatacg atcatgccgc tcgttgcttt cggcctcgca tttgggcttc 1762921 atcttccagc tgaaatcgca gttggtgtta ttcttgtcgg ctgctgtccc gggggaactg 1762981 catctaatgt tatgacattc ttagcaaaag gaaatactgc cctttctgtt gcggttacga 1763041 caatttctac cttattggca cctgttgtaa caccgttgtt gattatgctg tttgccaaag 1763101 aatggcttcc tgtctcgccg gggtctttgt ttatctcaat cttacaggcg gttttatttc 1763161 cgatcattgc aggtctgatt gtcaaaatgt ttttcagaaa acaagtggca aaagccgtac 1763221 atgcccttcc gcttgtttct gtcattggca tcgttgcgat tgtctcagct gtcgtcagcg 1763281 gcaatcggga aaatctgctt caatcggggt tgctcatttt ttcagttgtt atcctgcata 1763341 acggtatcgg ttatttactg gggtttcttt gtgcaaagct tttaaaaatg gattacccgt 1763401 ctcaaaaagc gattgcaatc gaagtcggca tgcaaaactc cgggcttggg gctgcacttg 1763461 ccacggctca tttctcaccg ctatctgccg taccaagcgc aatattcagt gtgtggcata 1763521 acctttcagg ttctatgctt gcaacatatt ggtcaaaaaa agtgaaaaag aagcaagctg 1763581 gatccaaaag cagcaatcta tcactttaaa tatgcatcaa aaagggtaca tcactttatc 1763641 gtgatgtacc cttttttatt atccttctaa taaaagctgt tcaggatctt ccagtaaatt 1763701 tttgattgtc acgaggaaac caaccgcttc tttaccgtct acaattcggt gatcataaga 1763761 taaagcgata tacatcatcg gacggttttc gaaacgctct tcatcaatgg ctacagggcg 1763821 cagctgaatc ttatgcatgc ccagtatacc gacttgcggg ctgtttaaaa ttggagttga 1763881 catcaatgaa ccgaaagtcc ctccgtttgt aatcgtgaag gagcctccct gaagctcgct 1763941 aagggttaat ttattgtttc ttgctttttt cgcaagctcg ccgatctctt tttcgattcc 1764001 tgcaaatgtc aggcgatccg catcccgtac aaccggaacg acaagacctt catcagcagc 1764061 aacagcgatt ccgatatcgt agaatttttt aacgatcaac tcatcgcctt gaatttctgc 1764121 attcaacagc ggatattttt tcaatgcagc cacgaccgct ttcgtgaaga aagacataaa 1764181 gccgagcttc acttcatttt gctcaaaaaa ttgatctttg cggcgttttc tgagattcat 1764241 gacagccgtc atgtccactt cattaaatgt agtcagcatc gctgatgttt gctgtacctc 1764301 tacaaggcgt tttgcaatcg tttgtctgcg gcgtgacatt ttttgcactt caacaggttt 1764361 gtcaaagctt tgctgtgctt tttgagcctg aggctgctgc ttttgctgag gagccggttt 1764421 tgatgccggt ttttcgtacg cttcgacatc ctgcttgcgc actcttccaa gcggatctcc 1764481 agttggaact tgagacaggt caattccttt ttctctcgca agcttacggg ccgacggaga 1764541 agcgatcgtt cttgattttg cttcagattg tgcttcctcg ctcacctctt gtgcagctgg 1764601 ttcagcctgt ttctcttctt ttacgctttc cttgctttct gttttctctg taggagcagg 1764661 ggcagaactt tcacccgcgc cttctgaaat cgtaccgata atttctccga cctggacggt 1764721 atcacccgaa tctttcaata cctcttgaag tacacccgat tcttctgctg tcaattcaac 1764781 attcacttta tccgtttcta gttcaagcag atattcaccc tgttctacat agtcaccagg 1764841 ctgctttaac cattgggcta ttgttccttc tgagattgat tctgctaatt caggtacctt 1764901 aatttccgcc attttttcat ttccccctta gtttttgcga gtcaagctat cagatacaat 1764961 acgttcctgt tcttttttat gaactgtcgg atctccctct gcagggctgg atcgtcttct 1765021 tcgtccaata tattgaacgc ttactccctc tggtgcaatc tctgtcaaat acgggctgat 1765081 ataaccccaa gcccccatgt tctgcggctc ttcctgcacc caaacgattt ctttcaggtt 1765141 cggaagtttt gcaaataatt ctttgactcc ttttgccggg aatggataca gctgttcgat 1765201 tctcgcaatg tgaagccact ctttaccgtc ttctaactta ttaaaatgat cgctaatgtc 1765261 tatagacact ttaccgctgg ataatacaag tctggttact ttttcatagt catgagaaag 1765321 tcccgactgt tcataaacag gctggaagcg gctttcgctg agctcctgca cttccgacac 1765381 cgtatttggg ttgcgaagaa ggctcttcgg cgtcataatg acgagcggtc tgatttcttc 1765441 acgaagcagc attttagcct gtcttcttaa aatatggaaa tactgtgccg cgcttgtcag 1765501 gttggcaacc gtccagttgt tttccgctgc aagctgcagg aatcgctcaa ttcttccgct 1765561 tgagtgctca ggcccctgtc cctcgtaacc gtgcgggagc agcatgacta atccggattt 1765621 ttggccccat ttcgcgcgtc cggcagaaat aaattggtca aaatacactt gagcagcgtt 1765681 ggcaaaatct ccgtactgtg cttcccacaa aacaagcgtt tccggtgaat gcacgttata 1765741 gccgtattca aaaccgagaa ccgatccttc agacagcggg ctgttatgaa cagcaaatga 1765801 tgtgctgcag tcagataagt gatgaagcgg cacaaattct ttgcccgtct cactgtcatg 1765861 aagcacaagg tttctttggg cgaacgttcc gcgctcggaa tcctgtcctg ttaaacgaat 1765921 cggtgttccg tctttcaaaa ttgaagcaaa cgcgagtgat tctgccaaag accattccac 1765981 ttttctgtca tcatcgaacg ccttggcgcg tctttctaaa atgcgcttta gcttgccgaa 1766041 aacattaaat gactccggcc agttgatcaa ttcgccattc agcttgcgga gcacatcaaa 1766101 atcaatcgaa gtgtccacat ctgggaaacc gtttgataca ggctctggaa gttcaatttc 1766161 acaagcagtg tgttcctttt tagacggaac tttctgatat gcatcctcaa tgcgcttcgt 1766221 taccgatttt tcgatgtttt gaacgacttc ctcggtaacc acgccttctt ttaccagctt 1766281 ttcagcgaaa atttgtttga cggtcggatg ctttctgaca gcatcataca gcattggctg 1766341 agtggttgac ggttcatcca tttcgttgtg tccatagcgt ctgtacccga tcaaatcaat 1766401 cagaaaatcc ttgttgaatg tttttcggta ttcgaccgca aacttaacag ctgaaagaca 1766461 agcttcagga tcgtccgcat tcacgtgaac aatcggaatt tcataaccct tggccaggtc 1766521 gctggcatat tttgtcgatc tggattcagc gctttctgtt gtgaatccga tcatgttatt 1766581 ggcgataata tgaatcgcac cgcctacttg ataccctttt aaagagctta aattcaatgt 1766641 ttcagctaca attccttccc cagggaatgc agcgtctcca tggattaaaa tggccagcga 1766701 ttttgtttca tcttgtaccg ggtatccgct ttgtgttcgc gtttcctgtg ccgctcttgt 1766761 gctgccttca acaatcggat tgataaattc caagtggctc gggttgttcg ctaacgtaat 1766821 gcgcgctgat tttgtttcag cgtcttgaag ctcccgattc gcccccaaat ggtatttgac 1766881 atcccccgtc catccgtagc tgattccaat ggatccctca gacggtacaa gatctttgtt 1766941 cggcgcatgc tggaattcag agaagatgat ttcatacggt ttgccgagca catgtgccaa 1767001 gacattcagg cgtcccctgt gcgccatccc gatgttgaca cttgtcgtgc ctgatttgac 1767061 agattgtgca ataatgtcat caagcactgg aacaagagcg tccagaccct caatggaaaa 1767121 gcgcttctgc ccgacgaatg tgcggtgcaa aaactgctca aagccctcta cttctgtcaa 1767181 tctttccagc acagctgaca gcttttcagc tgagttcttc tggaacagct cgccagattc 1767241 aatctttctt gtcagccact cgcgctcttt gaagtcatgc acatggtcaa attcaaaaga 1767301 gatggttctt ttatacgtat ttcgtaaata ctgaatggct tctaaaccgt tcgaaatgtt 1767361 tttaggagcg tctttgcaga tgacagacgc aggtattgct tttatttcct cttctgttag 1767421 cccgtaatcg gataatggaa aaagttcgct ctttttctca tcctttctga gcggattgac 1767481 ggaagcgttc aaatggccat aggttcggat atcttctgca agtctgactg cggatgcgat 1767541 cttttgaatc agatcggctg taacacgtcc cttttctttt gttcccgagg cctcttttat 1767601 atcgcttggc ggagcaccga gctcgtcgaa catttccttc aaatccgggt caatgctgtt 1767661 cggatcctgg gtatactgat cgtaaagctc cagcgcatag ccgaggttcg gaccgtaaaa 1767721 atcttcccaa ttcattcgtt gtttcatact attttgaaac atttgaatat tacccccaac 1767781 ttaaataatc aagtgattga ttcactatct tgaaataact ttcgaacgct gtgtccaaaa 1767841 ttatgtaata aaaacgcttc caacgatatt ttaccactgt ttgcaatttg attctacctt 1767901 gattgttcac aaaatagtaa aaaaccttta taaaaaacaa aaaatttaat cattcgaaaa 1767961 aacaaacgcc aaaaagcata ggattaaggg ctatcctatg cttttatgaa gcagtttttt 1768021 cagcagcgga tacaaaacat ccggtagctg atcaacatcc gggacaaata tactgaattt 1768081 tccgtacata tcctggatcg tcttcatttg cgattcttct atttctgagt tggagagaaa 1768141 aacatttatc acttctattc ctctttttcg ggcttcgata accgcctcac ttgtatcaac 1768201 gatcccattt tgttcgtagc caaatgcggc cggctctcca tctgagaaaa caattaagaa 1768261 cttttgcgcc tcgctgcgat gcagcatttt tttcgtcatc tgcctaattg cgtacccgtc 1768321 acggttatct tcttctggct caagctgcat aatggccggt ccagaatctt gtcttaatga 1768381 tgattggaag ggaataaccg tattgaaata gtttggctgg cttttttcgg ttgcatcatt 1768441 tgtgtcctcc caaaaaccga caatctgatg cggaaccgct accgatttca acgcttcgtg 1768501 aaacagcacg attcctcgtt ttgtttcgtc cattttgtcg aacatgctgg cggaacaatc 1768561 gaccagcaat gtaaaaactg cgtcgatttc tgaagatggt tcttgctttt tgtagaacag 1768621 gcgcggattt cgctcagtga agtaacgaag aagcttattg ttcagtctcc cggcatgaag 1768681 gtctgttctc ggcaatgttt ttttatgctc cagcgttttt tgaatcattt gtttcaaacg 1768741 cttttgatac gattcaatcg tttttgcctg ctgtttataa gaaagctctt cttcactggt 1768801 tgccggctgc ggttctttat aaattggaaa tgcatattta ttttctttgc cgtcagccat 1768861 acccgctccg ttcggctggt ctttttggga ctccagcgct tccagcttgg aatagtcttt 1768921 ccgtttcgtt tgtctggctg atccttgaac agagccaagg gcctgatctc catcgtcgcc 1768981 ttcccttgaa gcatcttttc ctaaatctga ttttgcgccg tgttcaatat caaattgaag 1769041 gaagctttta gacggtgctt ctgtttcccg gtgccatgtc ggcatttctt cttcatggat 1769101 atcctcatca ccgtctgatt gttttggaag cgtgatgtca tcactcagct tcggcgcttt 1769161 tttctcttct tcaaataacg gctgttctgc agcttttgcg taatcaagct caggcaaaaa 1769221 gaagtaggtg ttcaacatgt ctttatcgag tacctcttca agtccgtcca tgaggtcctc 1769281 aacaattttc agaacctgcc gtgtcgaatc tgcttcatac acacgcaaga gctgctgctc 1769341 aataaacggg cgcatcagat cgatatcttc acgcatggat ggaagggtct cgagcggcga 1769401 ttccgctgtg agcttgaaat agatcgcgca aaagagcgca tcggtaaaaa tgcttcgttc 1769461 caaatttaag gtcagctggg ttgagaaatg ttttctgtac atgtcttttc gcttcgcaaa 1769521 tacatgtttc gtacccgggc gctcacgttt gatgcattct tcgatcctaa tgtcttcaag 1769581 cagcataaag agctgcttgg caaaactttt aaacgtaaga tggcgatgga tatcattcaa 1769641 aaagttcgca aactcatgca gcgagctata tcttgttccg actgaacgca ggtagacgtc 1769701 gcttttcaga cccgcttcca tgtcctcagc tgccctgtct ttccaaaagt ggctcatata 1769761 gattttcttt tcaaatggat tgtaatagga ctgaacgcca tactccactt ctaccgcttc 1769821 actcttggtg agtgttttgg ccaaatcagt cagcatcata aataaaaatg aatcaatcgt 1769881 gctgtcgtta aatttgataa atttcatcgc agccccctca ttcaaacaga gtttctgcaa 1769941 tatttcggac agccgctttt tcccgatcat catcaagctt ttctacaatt ccccgctcaa 1770001 tggcacgacg cggcggaata taagcagcta aatcacatgt atcgattaaa gctctgatgg 1770061 atgccgcttc ttcagacacc tgtccgttat tggcctgaac gatcaagtca gaggaaagcg 1770121 tgataaatct gtcaatcaat ttctcgtctt tcaaggctga ctgagacatg agcacttgtt 1770181 tcagcagctc gcctttaata taaggcacat caatgatgac aaaacggttt ttcaacgctt 1770241 cattcagagg aacagttccg acatagcctt cattgatggc tgcaatgact ccgaaaccgc 1770301 ttttagcccg tatgacctcg cctgtaaacg gatttgtcat catttttctg taatctaata 1770361 caccgtttag aataggcagt gtttccggct tcgccatatt gatttcatct atataaagaa 1770421 aatggccttc cttcattgcc tttgtaacag gtcctgaaac aaactcgatt gttgcctggc 1770481 cagattgatt ttcaatcgtt ttataaccga ccaatgcctc agcgtccaag tcgactgaac 1770541 agttgacgct gtgcatcggt ttatgaaaat agctggacaa tgtttctgcc agctttgttt 1770601 ttcctgaacc tgtaggccct ttcagcagga catttttccc catggctaat gcaataatgg 1770661 cgtcaaataa aatggcttca tcctccgcct catagcctga tgttcctata agcgattgaa 1770721 actctgggga aataggctgc tctttatatg ataaaagctt ttgttgtata tcttccggca 1770781 atgttaagtg ctgtagttga gttgtcatag acagattccc tttcctattc atattccatt 1770841 aacgagtata ctaaaaaagc ccctgtatgc tcaatacaaa agggcctgga tgatattact 1770901 gcttctcgtt atttcccaaa agggctccgc agacaatacg cgcaccggaa ttgccgcttg 1770961 ggtttgtcag ataatcgtcc gcttgttcat gaataataaa tgcacttccg tcctcgtcga 1771021 gaatatttag tttacttcct tttttcagtg aagtgtcagg cgcattcatt atgacatcta 1771081 cctttccatc agcaccgact tcaaggttcg gcagatctcc ggcatgatgc cccatcggat 1771141 tattaaagcc gtgttctttg ttcagtggat taaagggacc gcccgctgat tcaaaatccg 1771201 gcctgacaca agaacctttc tcataaatat gaaaaccgag agaagcacct ggacgcaggc 1771261 tgtttgcgga aatatgaata tcgaggcctt catcatctga ttctttgatc tctataaaac 1771321 cgactgcttt cccttcacga ttgaccagct ggacatgatg accaaacgct gacgtttcaa 1771381 ccactttttt ttccggcacc cggttaggag ggtctggagg ttttttttgt ccgcatccgg 1771441 caactcccag tgccgtcagc atcatcaaca gcaagagacg gtgcatactg tctccccctt 1771501 gttttttcta acagtgtggt caatcattgt ctggtataaa caaaaaagcc tataaaaggc 1771561 tttttgtcat actcattttt aaaaataact tcttgcgccc aagtaccgct gtttccaata 1771621 cgaattgctg agattggaaa tgtcgacgcc cgatgagctt gcatgaataa aatcaccgcc 1771681 gcctagataa atccccatgt gagacgggcc ggatttatat gtggtaaaga agacaaagtc 1771741 tcctactgac ggctggctga ctttctgcat gacattccaa taccctgccg tactcaatct 1771801 tgatatagat gatacattat taatgaggta ataaatgaag ccgctgcaat caaaaccggc 1771861 aggcgtgttt ccgccccatc ggtaaggcac tccgacatat tttttcgctt ccgttatcat 1771921 tctgtcaatc ttcgaaccta tttgaatgtt tgaccctgag ttatcttttg gctttgttgg 1771981 ctttgtcgga tttgaaggat tagattttga tgctcccgaa atagtcagaa cctgcccgat 1772041 ttgcaacaca tccgatgata aattgttttt atcacggatg ctttggacag tgactccgag 1772101 ccgatttgca attttccaca gcgaatcgcc tgcttttacc ttgtacgtcg ttgtttttga 1772161 gggattggag tttgacggct ttttggaacc gctgtttccg ttcttaggtg aactgcttcc 1772221 ttttattttg agcacctgtt taggataaag tgtatctgat gttaagccat ttaaggtttt 1772281 taattcggct acagtcatat ttaagctgtt tgcgattttc cacagtgagt caccaagctt 1772341 gaccgtatat gtactttttg aagaacctga agaattggaa ccgctgtttt tctttgatcc 1772401 atttgatccg cttgaactgc ttgtcccttt gatcttaagc ttttgccccg gacgaatcag 1772461 gtcactgctc aggctgttta agcttttaag ctcagaaaca ctcattttat gatttttagc 1772521 aatcatccat agggaatcac catatgcaac tgtgtatgtt gatgttttgc ttgaattaga 1772581 tggggatgtc gtgctttttt tgctgctttc aggaacctta agactttgtc cgacataaag 1772641 caccgttgat ttcaatttgt tttcggattt cagagctgat attgtcgtat catactggcg 1772701 ggaaagtttc caaagagagt caccgctttt tacttttatc gtttttgctt ccgcgggtgc 1772761 tgcggccatc gacgacccaa caactgcaga aacagccaag ccggctacaa tcttcttttt 1772821 cattcattca acctcctaaa ctgttttttt gcaaaaacag ctagtatttt gtttccaaaa 1772881 atggcacaca actgttttat cgtcaatttt tcagcaagtt aaaccctttt caaacatttg 1772941 gcgcagcatt ttcagcatcg ttcgaccttt aaaccttcaa ataaacatct aacattttac 1773001 ataagcacga tatgtttttc gaaagtctaa ggaactattt aagcgagggt aaaaatgatg 1773061 gttttctatt gatgaacgaa gcagtttctc ctcctttctt gtctattttt ctaatcaatt 1773121 ctctatcggc gtgtcaaatc ccttcctctg cattcttatg aaatggcaaa aagcctgttc 1773181 tttcgataag aacaggcttt tacactatgc atttgctgat tgagtttttt gttttacagc 1773241 ttcaagaatg ctgtcggctg cttttttaga gccgcctgcc gctttcagtg attgtccaat 1773301 ttcttttgcc ttttcagcat acgaacgatt attcattact tcttgtatcg tctctttcag 1773361 taggctttca gacaattctt cctttttaat tacttttcct gcgccgactt tttctacctg 1773421 atctgcgaca acaaattggt cgcctcccat cggaatgaca acgagcgggg tttcaaaata 1773481 caaaccttca cttgtgctgt tcattccgcc gtgggtcaca aataagctgg ctcttttcaa 1773541 gatctcaagc tgagggacat acgggcgtac aatgaaattc tccggaatgt cgtttaactc 1773601 acttgtttta atatgcttgc cgatggaaag cacaacttta ccgtcaaagt ccttacacac 1773661 ttcaaggcat tgattaaaaa actgcttttg attattaaaa atggttccca ttgaaataaa 1773721 cagcacgttt tcattgtcaa tctgatcaaa tgggaaatca ttgtttccgg ctctttctgt 1773781 aatggaagga ccgacaaata catatcgctc gccaaattgc tcagccagtg gctgaaatcc 1773841 ccttgatgta aagacgattg tcaagtcacc atcagctaaa aaaacatcaa atggcttctt 1773901 gatctctgct tgaaaatcag catttaacgt ttctgcaagc tgctggtatg attcataatg 1773961 aggcgaatct tcaagtgatc ctttcatgta cgctcccatc atttccttcg caaattcctc 1774021 attcatcgca aaggttgtac acaatgaaaa tcttggcagc ttcagcatgt tggcaatgac 1774081 tttacccgcg agaagatggt gatcatatat gacataatca tacgattcat gtttgacttc 1774141 ctcataaata tgagtcgcga tatccttaca ggctttcaaa aaagcgcaga gcatttctgt 1774201 gaaatctctt tcttcatcgc cggttgcgtt tttcccgaag taatctcctc tgaaatcatg 1774261 atactcacga aactctatat caagagctgt gattttttct ttatattcct tcactgcgta 1774321 gtacgtaatg ttttctcccc gggatttcag ctccttcatc acaccgatag agggattaat 1774381 atgcccttca ccggggaaac cgatcattaa tacattagcc atgcggcagc acccttcctt 1774441 tgagaattta tgtaatattt tatacggtac tataaatgca taaacaggta aagtatttca 1774501 cttaattaat attcatcata tataactttt ctaccagttt atattccctg tcttcaagac 1774561 aaaaagcatt cagcttgaag cgaatgcttt aataaagatg cgaattcagt cattttgtct 1774621 catgatagga ttcttaatca ggcccttttt attattttta cgttcttggt gaaattaacg 1774681 gatataatac accgtctttg gcaaacgaca tcttccctgt ttcctctgaa accacgagca 1774741 ccagtgcatc cgtatagccc gacataccaa gagccgcccg gtgccgggtt cccaaatgga 1774801 tatccacttc cttcgtcgtc agcgggagca cattggctgc tgacacgagt ttgttttccc 1774861 tcactaataa agcgccgtca tgaagagggt ttccgggaaa aaagatgctt tcaattaatg 1774921 aagagctgat ctcggcgtgt agggaggtgc ctttttgaat aaaacgttca accgggtctg 1774981 ctctttcaat cacaattaaa gctccatgct tatgttccga taaggcttta atcgccttgg 1775041 ccagctcaat aaatgccggc gtaaattcct caatgtatga ttgcaaataa aaggaggatg 1775101 caatcccctg catgtcctga aaaacgtgcc ccaaatcatc taattcacaa aggagacact 1775161 ggtctttttc gtgaagcgtt ttcaagatta gagatgcatc acctaatatt tgctctaagt 1775221 acacctgtat tttccccttg aacgcatttt ctgatatctg ctcatagcgc atagccttca 1775281 tctcctgttt aaatttccaa cttttcacga atgcttatct tattgatgca cattctattg 1775341 gtaaaggagg gatgtaaaga atggaaatcg aaagaatcat tcagtatatt tgcacctttt 1775401 taggcgtgat ttcgctttct tttatttatg cccaaatgtt tagaaaaacg aaaccgacaa 1775461 aaaaagaata ggcccggcgt tcattgcttt ttatacataa aatgttataa tttctctcgt 1775521 tatgaaaaag aaacggagat caatgtatga aagaaactca aaacgcccgg gaaaaaatca 1775581 aacagctctt gcacatttta ataccgatat tcattaccca agcggggctt tctctgatca 1775641 cttttctaga tactgtgatg tcagggaaag tcagccccgc tgatttagct ggtgtcgcca 1775701 ttggctcaag cctttggacc cctgtttaca caggacttgc aggtatatta atggcggtca 1775761 ccccgattgt cgctcagtta ttaggtgcag agaaaaaaca gaagattccc tttactgttt 1775821 tacaagctgt atacgtggcc gcgcttctta gcatcgccgt tttagtgatt ggatatgctg 1775881 cagttgacct tattcttggc cgattgaacc ttgatattca cgtgcatcag attgctaaac 1775941 actttttagg ctttttatca ctgggaattt tccctttatt tgtttacacc gtgttgagat 1776001 cattcatcga ctcattagga aaaacgagag tcaccatgat gattacactc agttctcttc 1776061 caatcaattt tgtattgaat tatgtattta tcttcgggaa gttcggaatg ccggcacttg 1776121 gaggtgtagg cgcgggactg gcatccgcgt taacttactg gtgtatatgc atcatcagtt 1776181 ttttcattat tcataaaaac gcaccgtttt ctgaatacgg gatttttctt accatgtata 1776241 agttctcttg gaaagcatgc aaaaatttgc tcaaaatcgg gctgcctatt gggttcgccg 1776301 tgttttttga aacgagcatt ttcgcagctg tcacgcttct catgagccat tttcatacag 1776361 tgaccatcgc gtcccaccag gcagccatga attttgcgtc tcttttatat atgctgccgc 1776421 ttagcgtgtc catggctcta acaattgttg tcggatttga agcgggtgca gcccgtttta 1776481 aggatgcacg ctcatatagc ttaatcggca tcatgatggc gatcggcttt tctttgttca 1776541 ctgccgcctg tatcctttta ttcagagagc aaattgcggg catgtacact tctgaccccg 1776601 atgtgctccg gctgacacag cactttttaa tttatgcgct attttttcag ctttccgatg 1776661 ctgttgccgc accgatccag ggagcactca gagggtacaa agatgtgaac tatacgcttg 1776721 cggccgcttt tgtctcttac tgggtcattg gccttccggt cggttatatg gtcggtacgt 1776781 ttacaagcct cggtgcattc ggctattgga ttggattaat agcgggactc gccgccggag 1776841 cagttgggct gtttttcagg ctggcaaaac tgcaaaaacg ttattcgcaa aaacaacaca 1776901 tttaaaagag gtgatcaatc atggcaaaaa acaaaaaatt attcgagtat ctttcccagc 1776961 atgcggaaac catcagttca acatggtatg aaacaatcga ggagactgat cccaattcca 1777021 tttatgcctc aacagaccct gttgtcattc acaatttaaa gagccagaat cttgccttta 1777081 actataaaat aaaccgtatt tttatagatg atgaggacgt atacttgcct atactgaaag 1777141 aatgggcctt tgaagtcaca caggatcaag agcatttaaa aactcctatc cactatatta 1777201 ttcgggagtt tgtcagagtg agagatttat atgtttctta tgtgaaagaa tttgtccatc 1777261 tcaatcagaa tactgtgaaa agcgaagaag ccgaagacct gtatcacgcc cttataaaag 1777321 cgtttgatct tgtgattcat atttttatag aagaaatgta caaaaacaca agccttcagc 1777381 ttcaggccca aaaagatatg attactgaat tgagcgctcc ggtcatcgtg ctgtttcaca 1777441 gcgtcggact gctgccttta atcggagata ttgatacagt ccgcgccaag ctgattatgg 1777501 aaaacacact gcatcaatgt gcgaaaaaaa aggtgacaca actgtatatt gatttgtcag 1777561 gagtagctgt gattgatacg atggttgccc atcagctgtt cagtctgatt gaggcgcttc 1777621 gtttaatcgg tgtttcttca actttgtctg gaatccgtcc ggaaatcgcg caaacagcgg 1777681 ttcagctagg tttgtctttc gaaggtattt ccttgagatc cactctcgct tcagctattg 1777741 catcggactt aaaattaaaa aaggtataag gcttaaggcc ttataccttt ttgattaatc 1777801 attccattga tacgtccaat atatttcttc ttcaaaccat gttgccataa caggttcatt 1777861 atttttcaat ttctcttcaa gctctctgag catgccttct gtttgtgtgc ggtgagctct 1777921 taacgcattc attttaatat cagctacttc tttgatatca agtacgacat cagcttcgcc 1777981 gagaacctct tctctgttgc gggtaatggc catgcagatt gtacgcggac ggtcttcttt 1778041 ctttttgcgg tataatgcac ggataaccgc ttccccgcat gcatcatggt cagggtgcac 1778101 accgtgtccg ggataaaatg tgacaattaa acttggtttt acatcatcta tgatctcttc 1778161 catgatatca gctaaatact catcgtcttc aaattcgagc gttttgtcac ggagtccaag 1778221 catccgaagg tcattgatat ccatttcttt gcaagcgttg atgagctctt gttttcttag 1778281 cagcggcaac gtttcccgat tcgcgaaaaa tggatcgccc atatttctgc ccatttcacc 1778341 taaagtggcg caggcatacg taacgggaat gtcttttttt ctgtttaagg caatgaggcc 1778401 tgccactcca tatgattcat catcagggtg aggcaggatt actagtacat gttctttcat 1778461 tattattcac ccttttcttt aaactgtgaa cggtttttcg ctgatttgca gagaaatagc 1778521 cagtttaccg cccggcaggt gtcccgccat taataaacgg ttttcttcat ctaccgtgta 1778581 ttcagtcaag ccttcagcat aaatccagcc ttcttctgtt ttcaagccaa cgcggtaagg 1778641 cccgttgcct ttgatttttg cctgatgata agtgactttt gcattgcgaa tatacgcaac 1778701 aaccgtcatg ttcttttcat ttaagtgcgc tgaataagaa cctgtggtgg tttctaaatg 1778761 gatatataca gggcggtccg catatcgttc taaagatgct tgcacatctt cttttatgat 1778821 cgctttcatg attgctcccc tctttcttct tttaaatact ctgcacgttc tgtatgtaat 1778881 ttgaccagct gatatttcac agccggttcg agctgtgaat tcacaatgcg ctgaatcgcg 1778941 gcaaaatatt tttccagcat cggttttcgg agtcttggat gtgttcgttt atccaagagc 1779001 tcaagatcaa tcgcctctgc taccgcttct gcgtcatcat gtgcgagaga tcggttattc 1779061 caaagtgaag cataggcttt cactatctct ttatcattgt ccatcgtctt gctcctttat 1779121 gtcttacata catgaaatga ttatacataa tatatgcatc agctgaaaag ccaaaggcct 1779181 caatggcttt ttgacgcccg tttccacttc acttgtgaaa acgtaaacaa gagcagcgca 1779241 gcccatatac agctgaatgt aaaagccttc gagcttgaaa atggctcatg gtaaacaaac 1779301 agcccgatca gcagggtaat ggtcggcgca atatattgta agataccgac ttgatacagt 1779361 ggcagccgtt tcgctccttc cgcaaacaat aagagcggca aagccgtaaa cacaccggcc 1779421 aaaaagagaa gcagccacgt ccctccgctt tctgcacccg ctggctgaac atgtccgctg 1779481 aacagcaaat accccaatgc aatgggcata atcatgaatg tttccagcgt taaaccgatg 1779541 gcgctcggca ggcttgttct ttttttgctt aacccgtaca gcccaaagct gaatgcgagc 1779601 agaagcgcaa cataaggaat ggagccgtat tggaacgccg agatgatgac accggctgcc 1779661 gcaatcgaaa cggccactaa ttgcaggcga ttcagttttt cctttaaaaa taaaatccca 1779721 aggagcactg atacaagcgg attaatgtaa tagccaagac tagcctcaag caaaaagcca 1779781 tggttgacag cccatatgta tacaaaccag ttgatcgaaa tcaggataga agcaagaaat 1779841 aaagagagga tccctccgtt ctttttcaga gagcgcaact cctgccatcc tattttccat 1779901 tgccgcaaga aaaaaagtac gatacacata aaaacaaaag accatataat acgatgagcc 1779961 aaaatatcaa gagccggcag ctgttcgaga agcttccaat agagcggaaa caggccccac 1780021 atgataaatg aaacggctgt gtaaataacg cctttttttg tttctgcatg ttgcattgat 1780081 atccctgcct ttctttagag catcttatat tatatcacgt gaaagatctg gtgggcatat 1780141 actattttgt ccgtgaagaa aggatgtgaa gacaatgttt gagtggaaca agtactttcc 1780201 tttccacaat caattttcta aagaagcatt aaaaaaagct gatccgaaag aagttgaaac 1780261 gtatgtcaat cgtgtgatgg aaagtgtgtt cggcagtgat tatgcggctc aatttccttt 1780321 ccgcgatcct ctcccccaaa aagaacatcc cgccaaacct gatgcaaaac ctgatgtcaa 1780381 acctgatatt gatatattcg aaacagcaga ccatgtgttt gtaaaggtgc caatcagcga 1780441 agaatggctg gaacaagtga gaatcaaaca cacatctcac gaattatggt tggaaaacct 1780501 cccaagagca gatcatccga aaaaagtaaa ccttccttgt ttagtcaaac gcaaaggaac 1780561 aaaagccgtc tataaggatg gccttctgga agtcatgttt caaaagcagc aagactacaa 1780621 tatgtccgag gtagaaatca tccgataaaa aacggcctgc aatcgatgca ggccgttttt 1780681 tattaataga agccgggata tcccccgtat ggcacgccgg caccaaaacc gtacggtccg 1780741 cctccatatc cataagggcc aggaggatag gcatagggac gagaatagtt aaacagcgca 1780801 ctcccgagaa aaccgcctaa taaaccgccg actagaggag cgccaaacaa aaaaggacta 1780861 cgcgccggat atccggctgg acctgggatt ccgcgtaaat acgaatgatg agggtacatg 1780921 attttttcct cctttatgtc tgcctatacg taaagtattc agcaaggaag aaaaacgatt 1780981 gggctacgga ctgtctatga ttgttacatc acaagccctg ccaataacac acagccgagc 1781041 cctgtaaccg aaagaactgt tgtaagcagc gtccaggttt gaaatgtttc tttcatgctc 1781101 aagccgaaaa attcctttac catccaaaat cctgcatcat ttacatgaca cgcaatgaca 1781161 ctgccggctc ctgttgcaag caccattaac gcagggttta cactgccagc ctccataagc 1781221 ggagctgcca ttcccgctgt ggtaagcgca gccacggtag cagagcctag acacagacgc 1781281 agaaccgcgg cgatggtcca tgcaacgaat agcggcgaca tgtttgtttg acggaaaaaa 1781341 tcagcgacat aatcgccgac tccgccgtca atcagcacct gtttaaacgc tcctccccct 1781401 cctatgatga gcagcatcat cgcaatttgc gaaattgatt ctgaaataga tctgccgatt 1781461 tcctgcatag atattttacg ggcatatccc atcgtataga gtgcaagcaa cagcgaaatg 1781521 agcattgccg ttcccggagt gccgataaat tctataatgt cttttccttt tgaatgttca 1781581 ctcaataata aagaaaaaat tgttgccatt gccataaaga taaccgggaa taaagacgtg 1781641 acagcactga tcgcaaagcc cggtgtttca tccagctgaa attctttcct tggtcctaac 1781701 cccgataggt ttccatgctt ttgatacgca ccaggaaacc gtttcatcgc aaatttatta 1781761 aataaaggcc cggcaatcac agttgtcgga acagcgatga tgattccaaa aagcagcacc 1781821 tggccaatat gggcaccata tgcaactgag atagcagttg gagcaggatg cgggggcaaa 1781881 aatccgtgag taacatttaa ggcggcggcc atcgggattc ccagatacag aaaaggcatt 1781941 tttaattctt tagcaatcgc gtaaacaatc ggtatcaaca gaacaagacc gacttcaaaa 1782001 aatagggcaa tcccgatgat aaaagaggca accacaaccg ccgcctgtat tcgtttcctc 1782061 ccgaatttgt caatcagcgt aatggcgatc cggtagccgc ccccagcatc tgagacaagc 1782121 ctcccaagca tcgcgccaag tccaaacact aaagctaaat gccccagctg cccgccaatt 1782181 ccagtctcaa ttgaaagaac aattttattg atatccattc caagtccgat ggctactaaa 1782241 aatgaaacga caatcagtga gacaaaggta tttaatttta ctttaataat gagaaataac 1782301 agaatcagca ctccgacagc tacaattaaa atcggcatgg tacccctcca aaagtgtttt 1782361 atatgattct cgcgacaatg ttttggcgct tttcatgcct agatgaacag aaagcgcttt 1782421 cattaataac taaaaacgtc ttggttatat gattgttatc ttttgatcaa ctaatatgtt 1782481 catactaatc tcctaatcaa tgactgtcaa tcgtttttat gagcttgtct cgattaccta 1782541 ccgcctaacc caatgattta ttagttatat gttgattaac ttttggttat atgttatgtt 1782601 ttttaaagtt gactgccaat cattatatct ctccattgtc tggaagcaaa tgagacaata 1782661 tgagaacaga cggataacaa cttcataaga ggaggagtac acatgccatt attgcgtttt 1782721 gatgtaattg agggccgtga tgaaaaatcg ctgcaattgt tattagatac tgctcaccaa 1782781 gcgatggttg aagcatttgg tgttccggaa agagaccgtt atcaaattgt ccatcagcat 1782841 cccgcaaacg agcttataat ccaggatgcg ggattagggt ttcagagaac caaggatatg 1782901 gtcatcatta gcatgacaag caaagcaaga accgaaagcc aaaaggaaaa attgtatgct 1782961 ctgcttgctg aaaggctaga aaaaaaatgc gaaatttccc ctgacgacct catggtatct 1783021 attactgaga atggtgacgc agactggagt ttcggtctcg gtgaggcgca atttttgaat 1783081 ggaaaactat aagatttcgt ctccccacaa aaaaaagaag agagagctcc aaagaagctc 1783141 tctctttttt cataaatgcg gaagtcatca gtatagaagc atccagcaat acgaaaaacc 1783201 tggatctcct tttatatccg gtttaaatgc caattggaag ctgactgggt tttggctgaa 1783261 aatataaaat tttgctgatt tgcataataa gatacatcat aatccccatt tacaataggt 1783321 tggatgttat agcttattga tcatttccta ttttatatat ccccttcata tgcacatgac 1783381 atttttgcca atccggaaat atcagtctga caaatataaa aagtcatgta aacgggtgtg 1783441 aaccgtactt acatgactca ccatggaaac aaaggctctt tttcaggtgc cgctttcctt 1783501 atttctcttc ttcacacact gtgtcaccag gctcgcaaaa ttgatcggcc catgcctgca 1783561 tttcttgaaa tacagcttga agcgctgttc ctttttcagt cagcgtgtag atgactttga 1783621 ccggcgtttc agggagaacc tgccgttcga caatctcgtt ttgttcaagc tccttcaagc 1783681 gctctgccaa cattttttgg ctgatcatcg gtattgtttc cgttatctct ttaaaccgtt 1783741 tcggcccatc cattagcaca tggatgatca gaccgttcca tcgttttccc agcaatgaga 1783801 atgcggattc cattttaggg cacatcgtat ttcccataag tcttcatccc ttcatctatt 1783861 gattgacatg tattcaatga tccattacaa taatctttca agttacattt agtaagcttc 1783921 taacttttct attatcatac cacgtttatc cgaaggagga aacactatga cgaatactct 1783981 ggatgtttta aaagcacgtg catctgtaaa ggaatatgat acaaatgccc cgatctctaa 1784041 ggaggagctg actgagctat tagaccttgc cactaaagcg ccttctgctt ggaaccttca 1784101 gcattggcat tttacagtat tccacagcga tgaatcaaaa gcggagcttc ttcctgtagc 1784161 gtataatcaa aaacaaatcg ttgagtcttc tgctgttgtt gccattttag gcgatttaaa 1784221 ggcaaatgaa aacggtgaag aagtttatgc tgaattagca agccaaggct atattacgga 1784281 tgaaatcaaa caaacattgc tcggccaaat caacggtgct taccaaagcg agcaattcgc 1784341 acgtgattcc gctttcttaa atgcttcttt agctgctatg cagcttatga ttgccgcaaa 1784401 agcaaaaggt tatgacactt gcgcaatcgg cggatttaac aaagagcagt tccaaaagca 1784461 atttgatatc agtgagcgct atgttccggt tatgcttatt tcaatcggca aagcagtgaa 1784521 gcctgcgcat caaagcaacc gtctgccgct ttcaaaagta tcaacttggc tgtaaggata 1784581 tgaaaaacct tagtccgaaa tccggactaa ggttttttta tacaatcgcc tctttgtacc 1784641 attcacgagc ctgttcagct tcatgctgag tcagctgatg gcccccgtcc tgccagtaaa 1784701 cggaggctga tgccccgctg tcacgcaaat agcggtaaag ctcttctgat tcttccttcg 1784761 tgcaaagagg atcgtatttc ccggcaccga taaaaacagg gagccccgcc atatcaggca 1784821 gctcgatacc ccgaatcgga accattggat gatgcagaat agcccctttt aacacatctt 1784881 tataatgaaa aagcaggctt gccgcaatgt ttgcgccgtt tgaataaccg actgcaatca 1784941 ctcggccgcg attaaactga tgcgtttctg cagcctcgtc gataaaatct ttcaattctc 1785001 ttgtccgcac cacaagatcc ttttcatcaa aaactccttc actcagacgt ttgaaaaatc 1785061 gcggcattcc attttcaagc accgatcctc tgacaccaag caaatgggca tcagggtcta 1785121 taaaccgccc caatgaaagc agatcgtgtt cattaccacc cgtgccatgc aacagcaaaa 1785181 gtacgttgtc agatgttcct ttctcataaa tatgcttcat tataaattcc cccttttaaa 1785241 gttcaggtaa aatgtctgta atttgttgtc tatgtttctc cagccattca ggcagtttta 1785301 aggaagtccc tagctcagca aacgtttcat ctgtcataaa gcccggttca tctgtggcaa 1785361 tttcaaataa gataccgcct ttctccctaa aataaactga tgtaaagtat tccctgtcga 1785421 gaatttctga cgaaggcaga tggttttcag caataatcgg cagccatttc gcctgttcct 1785481 ttttcttagt ccgaaacgct acatggtgta ccgtaccata tcctccgact cctctttttt 1785541 caggatgtaa atggacatca atgacaccgc cgaccgccgc tgaagatgcc agtctgacaa 1785601 tctggtcttc ttcggccact ttggtgtatc caaagctttc cgttaacaat tgtatggtcg 1785661 cctgcgggtc gtaggaatat agcagcacac ctttcattcc cgtaattgct tcatttgttg 1785721 tgatcccgtc aggcgtccac tcgcttttgc cgcttttcgc atcctccatg atcgccagcg 1785781 gaaggtcttc tgtatcatca aaaataagac ctttttcacc aaacaacgtt ttttcctcta 1785841 ggctcagccc gcttttctca agacgttcct tccaaaaaga cagggagcct gagggaactg 1785901 aaaagtacac ccggcccgct tggccttttc ctaccgttcc ctgtccgctt ccttggaacg 1785961 gaaaaaaggt cattattgta ccgggatctc cgttttgatt cccaaagtaa aaatgatacg 1786021 ttccgggatc atcaaagttt actgtttttt taacgagcct gagcccaagc acttctgtat 1786081 aaaatcgcaa gttttcttgc ggatctctgg cgaatgctgt gacatggtgc aatccttctg 1786141 ttttcatttt ctcactccta tttatctcga tttcaagata tttattattt taaaccttta 1786201 ttgaaaagga tgcaaaccat gtgttttgat taaataattg aaaaaatcat ttttttctaa 1786261 taattatctt gtgatctttt cttacaactg ctattatagt gagcattatc atgtttcagg 1786321 aggaaagtaa atggttaaaa aagcacttat tgttattctc attcttttgc cattcgttca 1786381 gctcgcgctt ttgccgcttg tgaatcgaat agaaccgatt atgttcggcc tgccgttttt 1786441 ccacttttgg ctgctgctgt ggattattgt tacgccgtta tgctcgtttg gcatttatca 1786501 gatgcaaaaa aaagatggag gacttgaata atgcaaggga atctgactgc acttctcatt 1786561 actgctatta ttgttttaac cgttgtctgt atcggctttc tcgccggaag agacaaatcc 1786621 tcacgtactt ctgtggaaga atggtctgtc ggcggcagac gcttcggcgg tcttctcgtc 1786681 tggtttttag taggcgctga cctttatacg gcctatactt tcttagggtt gaccagtact 1786741 gcttttacag gcggaagtgt tgcatttttc gccattcctt attctgtgtt ggcctacttt 1786801 atcgcctact tcttcttgcc aaaactttgg aaagttgcga aaattcataa attaacaaca 1786861 ctcgcggatt atgcccggga acgttttaac agtaagcttt tggcaagcct cgttgccatc 1786921 gttggggtac tcatgcttat tccgtacata tgccttcagc tgagcggcat tcaagacacg 1786981 cttcaggttg ccggcactgg ctatattaac gtaaaattcg ttgtgatcat ttcatttatt 1787041 cttgttgctc tttacacatt cttcagcggg attaaagggc ccacatatac agccatcatt 1787101 aaggacattt tagtatgggt cattatgctg tttatggtgg tgtccctccc tctcattcat 1787161 tttaacggct ggacgccaat gattgacacg ttagtgaagg aagcgccgca aatgctgacg 1787221 ataccgtcag aagggccaaa aggcattcct tggtttatca cagcatctat tgtttccgct 1787281 ctggcacttt ttatgtgggc acatgccgct acaggtgttt tcacggcgaa aagcgctgat 1787341 gcagtaagaa aaaacagcat gtttttgccg ctttataata tcgtgttaat tttggttatt 1787401 tttcttggct ttatcgcctt tcttgttctg ccggaagata caaatccaag gctggcgctg 1787461 ctgcatttga ttcaaacatc ttacggcggc gtggcacaag gctttgcata tgccactatc 1787521 gctcttgctt cattaatacc ttgttccatt atggcaatcg gcgcatcgaa tttattcgcc 1787581 aacaacctat accgggattt gattcatccg aatgtgtcgc aaagcaagct gactcttgtc 1787641 acacgttcaa tggtgtttgt tgtcatcggt cttgcgctgc tgtttggaat gctgttcccg 1787701 actgccttag tgacacttca gctattaggt gtatccggta tggtgcaaat cttccctgcg 1787761 attgctgtca gcctgttctg gaaaaaccaa acgaaagaag caacggttat cggattatta 1787821 gccggcctag cggtaacgtt tattgtgtat atcactcaat ccgcacatgg catttatgaa 1787881 ggattctggg gattggccgc caacatgatc gctgtggtca tcctgaatcc gctgttcgtt 1787941 aaaaacgcgg gatccaatcc tgtcattgaa ggtttatttg gcaaaaaaca agacgctaat 1788001 ccaaatcaaa agggcgcata aaaaaaccat acgcggcagc cgcgtatggt tttttttaca 1788061 tttctttttt cagtgtttca attgcctttt ccatttgcgt atcattatca gacagcttct 1788121 tttgaagttc tatcattaat ttcgttgttg tatcgccagt cagtatgcct gtttcattca 1788181 gcttctcttt tttctggaac tgtttgacga cagatacaaa atcctggtca tacatactgt 1788241 taacctttac cttgtaacca agtgctttga gcattttctg agccactttg acgtttgtgc 1788301 ctgtatcacc tgatttgtac gttttatctg cgtccaaata cggcagcttc gcgtaatcag 1788361 gcagctctgc tttcacttga ggcttgatgc cttttttgtg aatccattcg ccatcagcag 1788421 tcagccattt ggcaactgtc agtttgacgg tagagccatc atcatattct tttgccgttt 1788481 gtactgtacc tttgccgaat gtcgtctcgc cgattaacgg tacgtttgac gattcatgaa 1788541 gggcagcggc cataatttcg gctgcgcttg ctgtaccgtc atttactaaa acgacggtcg 1788601 gcttggtcac tttccgttct ttttcggcct tcatgacttc ttttgaaccg tttttgtatt 1788661 caacctgcat gatgtttttc cctttatcaa tgaacaggtt gctcatcgta atcgcctgtt 1788721 ccattaagcc gcccgggttg cctctcaagt ctaaaatata gcctttggcg ccttttttct 1788781 ctaaactgtc aatcgcatct gtcagctctt tagctgttgt ttcagagaaa gaagtgattt 1788841 gaatttctcc gatgttgttg tctttcatct ctgaatagac agtctctaca ggaatggtat 1788901 cgcgcttaat ggaaagatcg atattcccca ctcccgctct gttcagttca agcttcacct 1788961 ttgtgccctt tttgcctcgg attaaagcga cggcttcatt tacattcatg ccttttacgc 1789021 tttttccatt taccttaatg atttggtccc tcggtttgat accggctttt tcagcaggtg 1789081 aacctttaat tggggataca ataaggattt ctccgtcttt ctcctctact tgggctccga 1789141 ttccttcaaa agatgctgaa atcgtctcgt cgaatgattt cgcttgctct tgatccatat 1789201 atgtagaata cggatcatcc agtgattgaa tcattccttt aattgctccg tctactaatt 1789261 tgtcatcatc tgttttttgg taataatcac ttttgatttg ctcatacgct ttatttaatt 1789321 tgtcgaactt gctgtctcct gtgcttgctg atttttggcc caggatactg gaattgcccg 1789381 taataaataa agtaagcgcc gaagcgacaa ctgcagtgat cagcacaata aaaaacagtt 1789441 ttaattgccg tttcaattaa acaccacctt tttcttctta cattattatc atggacgaat 1789501 tcttattcgt caactcggag cagaaatgaa agagaaacgc ccttcttttg cttttcataa 1789561 acctatgtct ttatacgaca tatgataagg aaaaaggagg attcgatatt gagccgatat 1789621 ttagaaatgc tgtccttatt cggtgtcgca ggggcgcacc caggcgggct ggctttttca 1789681 aaagcggtct tgcaaaaggc tgcaccctct ccggatcagc cgattcttga tgccggatgc 1789741 ggaacagggc aaacggcggc ttatttagga catttgctgt atcctgtaac agtcgttgat 1789801 aaagatccta ttatgcttga gaaagcgaaa aaaagatttg cgaatgaagg gcttgccatc 1789861 cctgcatatc aggcggagct ggaacatctc ccgttttctt ctgagtcctt ttcctgcgtc 1789921 ctgtcagaat cggtcctcag tttttcacgc ctgacatcct ctcttcaaga aatttcaaga 1789981 gttttaaaac ccagcgggat gctgattggt atcgaagctg ctttaaaaaa accaatgccc 1790041 cctgcagaaa agaagcaaat gatggatttt tacggattta cttgcttaca tgaagaaagc 1790101 gaatggcata aactcctaag atcctatggc tttcaaaaaa cagaagcgat gtcacttctt 1790161 ccggaagaca tggaatttga accaaccaca gaaatggatt tatcgcaaac gattgatccc 1790221 atctattacg atacgcttca aacacattat cagctcatgc agttatatag tgagtacatg 1790281 ggtcattgta tttttatcgc gtacaagtaa aacggcgtat cgccccctgt tttcgtccaa 1790341 cctttttttc ctatctatca tatgctgata gaaagtcagg ataggagggg aacaatattg 1790401 gagagatatt atcatctttg caaaaaccat caaggtaaag tcgtcagaat tacagagaga 1790461 ggcgggagag ttcacgtcgg cagaattacc cgtgtaacaa gagacagagt ttttatagct 1790521 ccggtcggcg gagggccaag aggtttcggt tacggatatt ggggcggtta ttggggatat 1790581 ggagcggctt acgggatttc cctcggttta attgcaggag tggctctggc tggtttattc 1790641 ttctggtaag catagaacaa atgctagatt caccagacac aatgaagccc gcttatctag 1790701 tgtaagcggg cttttcattt taaattttct tcactttttc aaagtactct tcaagcgtta 1790761 aatcattatc ttggatgacc tttgcggctt ttttgcctac atagcgcaga tgccatggct 1790821 catattcata tttcgtgata tcttctttat ttttcggata gcgaataata aagccatatt 1790881 tataagcatt gtcctgcacc catttcccgt ctgccgtgct tccgaacgct tcatttagct 1790941 caaagccatt gctccggctc gaaatgtcca tcgcaaggcc tgtttgatgc tcgctttcac 1791001 ccgggtaagc gaccgcttcc tttgccttcc tttccccttt taggcttact tcattgtcaa 1791061 aaatgacttt ctgtctgtca tacgaacggt accctgagac agctgccagt tcatagcctt 1791121 cctttttggc agcatcgaac attgttttta atgcgtcggc cgcttctttt ctgatgtaac 1791181 gtttttgaat cttttcttca aaagaaaact ctacatcagg tatgacaaga tcgctaggtt 1791241 catagtttcc gggcagtgca tattgtttat tgacaagcgc gagtatattt tctggatttt 1791301 gaatggtttc cagaccatcg acttttttaa tatcattgaa atactggctt tccaatgaaa 1791361 actcactgtt ttgagtgttt gattttttgc tgtcagctgt tttttgttct gtttgctttg 1791421 tttctgctgt ggttttcgta tccttttgag catctccgtt cgacatgctg cagccggctc 1791481 cgactattgc cgttacactc agagcggcag ccagtgagaa ccatttaccg gactttttca 1791541 tattacatta ccttcctttt atcaatcgtt tccgcatgca taaagaagag gctgccggca 1791601 cccagcacgc ctcttgatat attttattgt gatacggaat gtaaagccac ttctatcata 1791661 tcatgaaatg tcgtttgacg ctcttccgct gtcgtttctt ctcctgttaa tacgtgatca 1791721 ctcacggtga gaattgacag ggcttttctt ccgtgcttcg ctgctaatgt atacaatgca 1791781 gttgtttcca tttcaacgcc aagcacaccg tattttgcaa gtttttcaat ttgcgaatcg 1791841 tcattgtaga actggtcagc tgtaaatacg cttcctacag tcaccggcac acctttatcc 1791901 tttgcggcat cataggcatt ttttaaaagc tcgaaatctg cgcaaggcgc aaaatcaacg 1791961 cttccgaaag caactctgtt catttgtgaa tcagttgagg aggtcatcgc caaaatgacg 1792021 tctcgcactt tgacatcttt acgaatagcg ccgcaggaac cgactcttat tagattttgc 1792081 acatcgtagc tttgaattaa ttcattcaca taaattgaaa tagacggaac tcccattccc 1792141 gtgccttgta ctgagatttt tttaccttta tatgtacccg taaatccata catgcctctg 1792201 acttcattgt agcattctac attttcaaga tacgtttctg caataaattt tgctctgaga 1792261 ggatctcccg gcaaaagcac agtatccgca atttgtcctt tttcagcacc tatatgtaca 1792321 ctcatctcat atcctcctgt aaatctaaat tatcatccag cccgtccatt ttacaacgaa 1792381 tgtcatgatg aaacaaactt cagcattgat tataaaggaa tatatcgaaa aaagaaatgt 1792441 tcgaggatct gttaggcact tcctcagaaa aacggataat cggggtgtta atttgaaaac 1792501 ctaaccgcag gaaggagggg tgggacatgg gtaaaaaaca tcgtaaccgg atcaccggcc 1792561 aaaaaaagaa caatcatata cctgaaaaag atatcattgc agctgaagaa gcacacggga 1792621 aagaatattc cgctgccaaa cgcaagcctt aaaactgcag aaaactgcgg gtttccgcag 1792681 ttttcttttc attatgtcgt ttgtacaatc agacgattga ttttcctcca gccggcggga 1792741 agcagttgat aatatgtttt cccttttctg ccttcatcaa tcaggatcac gtcccctgtg 1792801 gccatgaatc ttgcatcata atcactcgga acagtgtcga atacattaaa caaagagaat 1792861 gctcttttca gcacgtcttg atgatcgctc ccgttcagtt cagttcgata gacggctctg 1792921 tagccctttt tttcgccaaa ccggggtgtc tgaaatattg tcacgtcata ggaacaagac 1792981 ttctttttaa acacggataa catcatcaag atcccctccc ttttatttct ttaacatatt 1793041 ggcgtttttg ctgtgttttc ctctctctat ttttgtcgaa accgcttaat cttttcgtca 1793101 aaacctttta ctaggaaaaa cagaagcaag ccgaggctaa agcctcctaa cacgtctgtc 1793161 acaaaatgaa cccccagata cactctgctt atgccgacta aaacagcaat tacaccggct 1793221 atgatatata ccattttttt atgcttagac aaaaacggga gatgtttcac taaaaagtaa 1793281 gcaataacag gatagacaca agcagcattc atggaatggc cgctcggaaa actgaaggat 1793341 gattcatgaa ccagcggtgc aaaatcaggc ctcactcttt cgatccattc ttttaagact 1793401 ttgtttaaca gccgatctgt gccgaatact aagagcatca acaggccgtc ccatgttttt 1793461 ctgtagaaaa acatgcctgc tccaatgatg acaattagag ggagcagaaa agaagaagca 1793521 ccaagatgcg tgatccccgt catgacttca ttaagccatg gctgacggat caaaacagct 1793581 gccttgctta ttgcttcatc tgcagattga acagcatttg tatgaatggc cgcagctaga 1793641 attaaaaaga aaagaaacaa actaacgggc ttgtacaatt ttaaccacct caattttcac 1793701 agaagtcata gaacatgaat aataaaaccg gagctgaccg ctccggtttt aagcctcact 1793761 catcttcatc cagctcttca tctatcatac atttttctat caaataatca aaggtaatat 1793821 cagcgatttc aaacagctca tcctcactcg gtatgtagcc ccgtcttgca agctctctgt 1793881 aaaaaaattc agcgatttct tccgtatcaa tcacaagatc tatttctttc atctccgtac 1793941 cgcctccttt tttatgtttt atgaaaaaac aggctgaatt atacccggtg ttctaaacaa 1794001 ttctttcagt catatattga ataaaaaacg agccatggga ggctgacgct atgattgcta 1794061 aaatgatgga agcactggac ggagaaagat ttgatatcat aatggaaaaa acgctcaaag 1794121 gaatgacgcg tgtgatgatt tggggctgtc tgccatattt tttatatgtc ttgatccgta 1794181 tgttcacaaa ttaactgaaa tgctctttta aactttccaa aacaaacatc atcatgtctt 1794241 tatattcttc atcctgaaac atttcgtaca gaattttgta gtcattataa atatccagaa 1794301 gctcatcaac aattgacaca gcaaggatgt gaagggtatc ttgatcttca tcaccgcctt 1794361 caaactgaag aagagcagac gatgcgatat cttcgccgat ctcatggcca gtttctccga 1794421 cataatggac aaacaacagc tgatgcacaa actggtccat ttcatatttt ctaagcacca 1794481 gcgtgagatc ctcttcctcc gtttcaagcc actctccatc ctttaaacgg gtcagctcat 1794541 aaatgatatc ttcccagcca tcttctaaat atctccaaat ttctgttcta tggccgataa 1794601 tgcgaaagag ttcttttcca taatctttaa cataaacaac gtccccaata aggaattcat 1794661 actcaatatc aagcttctcc atgtcgacaa tgacaccctc ataatcttta taaagctgaa 1794721 tagatgattc aaagtataaa acttcgttat gattgacttc ataaagatag tgtttatcaa 1794781 tttggtgtac ttttgtgatg gtgccgactg ttccatacat aatgacgact acgatatccc 1794841 ctacttggaa tttcggttta ttttgcttca tggtgtctcc ccctcgccgc aacatttctc 1794901 atacgctatc gtatgccggg tgaagccaat tcgcatgggc atgaaaacca aaggaaatat 1794961 ccaattatgg tatgggtatg gacataaaaa aatccgcagt gatctgcgga tgaaacagct 1795021 attatctgcc gtgcacttca gactcgtatt gatcccaagc ttcatcaaac gtcgccatcg 1795081 tgtgaaggta atcagcattc agctccaaat atgaactgat ttcatgataa tcggttgatg 1795141 tttttggaaa gctgtgatcc tcatacgcct gattggcaaa ttcactgatg ctgtccttcg 1795201 gcttagggtg tctgtatttc aataaatagt gataaaagga tttcatgggt ttcccctcct 1795261 gatgtctgtc ttttgttgtt ctattataca gttcaagtgt aaaattacaa caaaagaata 1795321 ctgaaacatg actcaggaga agtcaaaata gttgcgtttc aaaattcttt ctgtctccat 1795381 gagctgctga tatgtcaggc tttcaggcag tttttttgtt tgaattaaaa gcagctgatc 1795441 ctcaatctct ttaaccgtgt tttcctcttg ataggtcata ccgcaggaag aacataccat 1795501 ggcaggggtg tctgtcagtt ctatagccct cgttccatca gggagctccc agtacaccgt 1795561 gttcctgccg ggcaccgctt cgagctcgcc gcaccattcg catgttttca tgaagaatcc 1795621 cctccgcatt cagtctcttt ctgttttttc tgctgcgcca aaaatttctt ttctttgagc 1795681 tgatctcttt tctcacgccg atcttttaat gtttcatgct ccggatttgc gatgtatgcc 1795741 tctctccttt tgattctgtc tacattttca ggtgtaaacg aaacttcttt gtcagcaaaa 1795801 atggcactca gcccgatcgg ctcctttttg tcagcggttt cagggaaaac ggactcaaaa 1795861 taggcgtctg cctgattggg gatataattc tctggttccg gatatgacgt aatcacacct 1795921 tcaaaatttc ttaagatcac tttgtcagga ctttgtgaca ggacatagtt tggctgcagg 1795981 gcgattttac ctcctccgcc tggtgcgtca acgacaaagg taggaaccgc atagcctgag 1796041 gtatgacctc tcagcccttc aatgatctcc aaacctttgg aaacaggagc tctgaaatgc 1796101 cctattcctt ctgacagatc acattggtaa atataataag gacggactct gatttttacc 1796161 aagtcatgca tgagcttttt cataattgga accgaatcat taatacctgc taatacgaca 1796221 gcctgatttc cgaccggcac tcccgcgttc accagctttt cacatgcctc aacggattct 1796281 tctgtcattt cgatgcttgt gttaaaatgg gtgttcagcc agaccggatg atattttttc 1796341 aatatctcgc acagatgatc ggtaatgcgc tgcggaaaga cgacgggagc tcttgttccg 1796401 attctgatga cttccagatg cggaatgctg cgcagctctt ttaaaatata ttctaaaatt 1796461 tggtcgttga tgagcagccc atcaccgcct gaaattaaac aatcgcggat ttcgggtgtt 1796521 tcccggatat aagcaattgc agcatcaagc tgttttttgg ggacgcccat tccgatttgt 1796581 ccggaaaagc gccttcttgt gcagtagcgg cagtacatgg aacattgatt cgtgacaaga 1796641 aacagcacac ggtcgggata gcggtgtgtc agaccgggta ccggtgaatc ttcatcctca 1796701 tgaagcgggt cttccagatc gtattttgtt ttgtgcattt cttcagaaag cggcacagac 1796761 tgcatgcgta ccgggcatct cggattgtcg gggtccatta aagaagcata gtaaggtgta 1796821 atatttaagg ggatcgtttt ggtagaaatt ctgacgcctt cctcttcatc ctcggtcaga 1796881 ttaatgactt tctttaaatc atctaacgtt cttacagtgt gtgtcagctg ccaaagccaa 1796941 tcgttccatt tctcttccgg aacgtccttc cataactcga tctccttcca atgccgtttc 1797001 ggtttatacc atttgttttt caaacgaact cctcctcgcg catattttga cttacagttg 1797061 cttgcaccaa atattcatgt tttcaaggcc ttcggctata aagcaattat tgatcagcct 1797121 tccgccatac tgataacctg aatggtacaa cacagcattc atcccaaaag acgaagcacg 1797181 ggcgagagaa aacacatgaa cgatatcctc tccagccatt tctttttcta acgcctcgat 1797241 taaaaagctt gttaacgaat ggccgcgata ttccggcagc acagcgcaat cggttatttc 1797301 tgcatgccca agctctggat tgatttctgc gcttgctgcg ctgatcaggc ggtcatgatc 1797361 aagcatgata taatacaccg tatttgcatt catcgtcttt tcaatataag cggggtcaaa 1797421 taccggggtt gggtacgtgc ggaatacttt tttatacagc atcgatagct ggtacatgtc 1797481 gtttgtttct gcttttctca tcgtaaaaac gggtgtactg tcgttgcgaa gacggggcgc 1797541 tgtgcgatat atggcttcga tgatctcctg ttcctctgta taagaatctg tttgtctccg 1797601 gctttctgaa aggtaacgta ccatgacaca agccgaatgg ccgagataat agccctttag 1797661 atagccctcc ggcgcaaata attgtttggc aaggatcggc tcatcatgct gcttcgcata 1797721 gacaatgatt ttttctgcat tctcttcttt tgccgctgcc acgatatccg gcagggcctt 1797781 ctcaatggct ccgtcataac gaaccactct gattcgttta ttaaagccgt catggtccaa 1797841 aactgctgtg acaccgctac tctttattga cttgagcatc cgcatcctcc ccatctgtat 1797901 gaaggccgca ccaatccatg acaaaaagtg caataatttt agcagattct atcatggctt 1797961 caacctcaat gtattcattg gcctgatgag ccgtttttgt ttcccccggc ccgaaaacga 1798021 tcactggtgt atctcctgca tggtacaaaa gccctccatc cgttccccac ggggaagcct 1798081 caataatcgg ctctgtctgt ttcatttttt gataggctga ttgcagcaca gaaattaaag 1798141 ggtgatcatc aggtaaatca ttcggcagcc attgagcgcc aaaccattcg acttgtacgg 1798201 gatggcgttt aaaccattcg tcatggtatt ctaaatcctt cagccagttt tccaattcaa 1798261 gttttacagc ttctggtttc tcatggggag caattccgca tctcccttct atgacgacac 1798321 ggtctgcaac tgaagatggc caggcaccgc ctgagatggt gccgatattc accggtaccg 1798381 gtattgggat attgtcatac agcggatctg aaattctcgc attgcggact ttctccagct 1798441 cttgtatcgc tgtgataacg tgcatgcttt tttcaatcgc gcttacccct tcatagcgtg 1798501 tgcccccatg tgcggataat cccttcacag tgatccgaaa ccacatcgaa ccctgctgct 1798561 taataaatag tttcatattc gtcggttcag gaatcagcgc cccgtcagca cgatagcctc 1798621 tcatgatggc ggaaagtgta ccggcgccgc cgcactcttc atctacaaca ctctgaaaca 1798681 atacatctcc cttcagtttg acatcgcagg cgtgcagggc ttctaaagca aaaagaaggg 1798741 ctgtattgcc tcccttcata tccgttgagc cgcggccgta tattttaccg ttttcttcga 1798801 cagcttgata cggttcatac ttccaatcct ttacgcttcc ttcaggcaca acatcgatat 1798861 ggccgttcaa aatcagggac ctgcctccgc cggctcccgt ttttttagcc acgatattcg 1798921 ggctctcatg aaaatcggat cggttagatt taaagtaggg atgctgtttt aattgcttta 1798981 tgcttggctc ccatacatca atgtccatat gaaattgccg cagcttttca agcacaacag 1799041 cttgggcgtt aaactctgac cccaatgtgc ttttttcccc aatcagcctt ttgagaagac 1799101 gaatggcttt ggccgaatgc tgatcaagcc actcgattac ttttctttca atgtcttgca 1799161 tcctcattcc ccctcttaag aaaaaggcat atctattttg atttcagctt ctgtcagcct 1799221 cgtcacctca tcgattgtcg agccattcat cagctctttt aaaatgaagt gatggctatc 1799281 gacctcaaga accgcttttt cggtaataat caaatctaca cagcctgcag cagttaatgg 1799341 cagcgtacat ctttctgtta atttaggcct tcccttttga tctgtatgac tcatgacgac 1799401 aaccactttt ttcgcttttt gggcaagctc catcgccccg cccataccag gcaccttttt 1799461 tcccggaaca agccaatttg ccaaatctcc tgattggctc acctgcaggg cgcctaaaat 1799521 cgtaatgtca attttgcctt ttctgatcat cgcaaaagac atggttgtat caaaataaga 1799581 agcccctttt acagcgcgga caggatatcc cgcggcgttg cataaatgcg catcctcttc 1799641 tcccttttcg ggactttctc caatgccaag gacaccgttt tccgcttgaa acatgacctg 1799701 catgtcaggc ttcaaaaagt tcggtaccaa ggaagggata ccgataccga gattcacaat 1799761 catgccctgc ttaatttcag tagcagcgcg ttttgcaatc tgttctcttt ctgctactcc 1799821 caagcccatt tccacttcac tccctcgctt cgtacaaccc cctcaacaaa aacccccggt 1799881 gtgacaatca tttcttcaga aatctccccc atcggaacga tacgctcagc ttcggcaaag 1799941 gttctcctgg cggccattgc cataagcggg ttcatattgc gcgcggtttt gtcatacgtt 1800001 agattgccga attcatctgc aatgtaagca ttgatgaaag caaaatcagc agtcagcgcc 1800061 tcttcaatca agtatcgttt tcccgccact gttacgatgt cctttttttc gcaaaccatt 1800121 tgattatcaa tgcccacgtc ggttaaaata ccgccaagcc ccgctccgcc ggcgcgaatc 1800181 cgttccgcaa gcgttccctg aggtgaaaat tgaacctcta acgtcccctc tgtcatctgt 1800241 tttccggcta ctggattgga accgatatgc gaggcgatca gggttttgac ccgttgatta 1800301 acaataagcg ggccgattcc gatatccggg aaaccggcgt cattgcaaat cacagtcaaa 1800361 tccgttacac cgctgtccaa tatcgcttca atcaatgaag gaggcgaccc gactccccca 1800421 aaaccgccaa acatcagaac cgatccatcc cgaacatctg caattgctgt gtcaatgctg 1800481 attgcttttt gaaatggcgc catttaatgt caatcctttt ttaagttttt ttcgaccgct 1800541 gcaactgttt ctgaaaaaat agagataagc tcttccattt caccgtctga aatagtaaaa 1800601 ggaggagcaa taatgacagc atctccttct ccactgtcta ttccagcttt ggaaggataa 1800661 acaatcagcc cgcgtttttt cgcctcgctg acaataagct gggttatcgc ctgctctggc 1800721 ggaaacactt tcttcgtttt ttggtctgcc acaaattcaa tgcctaatag cagtcctttt 1800781 ccgcgcacct cacctataat gccgctttga gatgccgcct catcaagctt cttcttcagc 1800841 acagcgccct ttttttctga ttgtttgatc aagccgtgct ttaacacata tcgcaaaact 1800901 tcaagagcag ctttggctga atagggatgt gcactatatg tgtgaccgct cataatcaca 1800961 cctgaccctt gttttatggt ttcaataata gaatcagata cgacggcagc agcaataggt 1801021 gcataccccg caccgagtcc cttccccagt acagcaatat caggtacggt atcccaatgc 1801081 tctgtcgcga gcatccttcc tgttctccca agccccgtca tcacttcatc tgcaataaaa 1801141 agcacatcgt gtgtgcggca tacctcactt aatctctcat aatatcccgg aggcggagta 1801201 atcgctgctc ctgcagcacc aataataggc tcagccacaa agccggcgat gaattggctt 1801261 ccgattcttt taatcatggt gtccagttca tcagctgcag tctgaacaaa gtcttcttcc 1801321 gtctcgtgat tcagccgata aatatgtgga gctgagatag ctggataccg ctcaatgaga 1801381 tgggtgaacc ggtatctcct ttcataaaaa ccagacaatg aaagcgctcc caaagttatt 1801441 ccgtggtaac tgctccatcg agacaaaaag atggattttt gtgtttgctt tttttcctgc 1801501 caatactgaa tggcgatttt catagctgtt tctatcgctt ctgatccgct gttgacaaaa 1801561 aaagaccaat tcacatctcc gggcagctcc tgtgccaaga gagcggctaa ttgctcggcg 1801621 ggctcactcg taaactgtga gcggtaagca aaagacacct gatcaagctg ttctttcagc 1801681 ttctcagtca catcacgaac tccgtggccg atattacatg tcaccgcacc tgacgagccg 1801741 tcgagatatt tttttccggt ctgatcataa acatatgaac ccttcgcata actgacaacc 1801801 ggataggccg agctaagctc tggcttaatc aaataactgc tcatgctccc acctcaaaac 1801861 cccttttacc atattgtatg agtgtccaaa tggcggcatg acgttccccg caaaaacttt 1801921 ttcacataaa aagagccttc ctaataagga aggctctttt gaaatttcag catctagcaa 1801981 ataaaagcgg ctccaacaat aattaataaa atgaacaaga caacaattaa cacaaatgta 1802041 tttgtcccgc agccaaatcc gtaaccgtac ccagagtatc catacatgct gttttcatcc 1802101 tttcttatca cgatatacga cattttatgc gggccaagtc ccaaatggtt tgtgcaaacg 1802161 cctatttcat gtaaggaaat aatgaaatac agtatgcacc cgctcatatt ttttaaacgt 1802221 cagcttttcg taaaactgag ttgcaccgtc agtgcttgca gccactaagt aggctgcttc 1802281 cattcctagt gatttggcga tggacagcat ttctttcact aagatactgc cgtagccctt 1802341 cctttgaaac tgatctaaaa ttgccacttc ttcgatttta gccgttttct cttgatgatc 1802401 gataaacagc tcgccgcacc caatgggaac tttctgtgcc tggtcgctgt aacaaacaac 1802461 aagaatgatt atatctgctt catagaaagg atattttctt tttaattttt gttcagcgat 1802521 tgcttctcca atataaatgg aatcgtaaat tttcataata gaagatccgt cgctaagact 1802581 ttttgccgtc ccccatgcgg ttaaaggatg tcccatctgc cccttccagt cactaagctt 1802641 catgtcatat agtagctcat cctcgacgac aaaaccgctt tttacaagtg actgcttcaa 1802701 accgagcgga aaaacatgct gcggcgacgc ttttaaatgg agataattcg catcaagcag 1802761 ctttggtacg gagggtaaaa agttaagtaa ccgctccaat ggaaacgtat catggagctg 1802821 aacaaagtta tgagaaaaaa tttgcggaag ctgcggatct ctgtatacgc tgtaatgatc 1802881 aaacgatgcc gattcagacg ttaacaatat atattgatgt tccgtttttg aataatgtcc 1802941 tgtcatgaac gtctcctttt tatgacctat acctttactc tgttgcaata ttcaatttct 1803001 ttataatctc atcgtacacc ggataaaacg gctttccaat tggaaattgc tgaatatttc 1803061 ggaaagaagc ggagattggc ttctgatgta aaaaaaactt ccttgttact tgttcactaa 1803121 tcgggtgaaa gacgccgttt agaaacaaaa acggctcgcg ttcgatgaaa aacagacgtc 1803181 ggccaggcgg atttttgatc aattcagatc gtttccacgt aatcggcggc ccttccggaa 1803241 gcgtctccat ctcttctttt ccaattgtca ctatgtcttt tctttgaaat tgataaaatt 1803301 gaaacgcata ctggtccaca attcgccttt tttttccggc ttcgatataa aatattgcag 1803361 gatggtcagc ttcctttact aaaatataat tcggaatgtt taaaattttg ccaatcctat 1803421 attggaataa atatgggtct ggaacagcga cagtccgatt tagatacaaa aaaccccact 1803481 tttctccaac aggatgcctt acaccctgat caaaaaaata cacattttga tctgaacctt 1803541 ttacaaaaga gccgtcaatc aaatcggcgg gcagaaaccg atatgcattt tgaaatgaat 1803601 ctggggtttt ataggttgtg tctaatactt catttatcgg cagaaatggg gtaaagttgt 1803661 tgagtctcgc ccaaaaaatt gcgtcgccat gattccaatg cttcatatca tcatcccagt 1803721 agcctccaaa tttatggtga atgagattaa gtaacgaacg gcgatgcata actgagcaat 1803781 gatcaacttg aaaagcggcc tgatcaagca ctgcattggc atttctgtag aaatgtgaga 1803841 tttcctctcc cctttcgttt acatgtacaa ctttttgttt tgaatagacc gcctgcgctt 1803901 caggcttatg tgaaaactct tgcaccatac ggctcagccg ctcaggatga taaacagtgt 1803961 cgtcagtaag ataggaaatg taatcgccgt ctgcaaatgg gagcgcactg ttaattaatg 1804021 tggcataacg ggctgttttt aatcgatctg caggatgcac gaaactgtta tgatattgaa 1804081 tgcgccggtc atggagatac ttgtgaatca ccgcagttgt ttctgcattc gaatgatcat 1804141 ccatgataaa aagctcccaa agatcatgcg tttgctgtat cacgctttcg atcgcttttt 1804201 gcaaataatc gggtttgttg taacttgtta aaataataga cactttctct cccatctata 1804261 ccgcctcccg ccgtcaaaca taaaaacggc tccgcagcaa gcagagcctc tgtcatcatt 1804321 taaaaagcac cccagcttac aacacttgag agtgaaacat gagatctcgt gttatttaac 1804381 gggttttgga aaataaccaa atcagtcaga acttctttta cgatgacatt ttgaagtgta 1804441 tctccgttga tcaaattgac ttttgaaacc ggtacgccca gctcttttgc aaaaacaagc 1804501 tggcgtctga ggtcagatgg atttccttca gaagacgatt gacgtatcag cagaatcagc 1804561 aaaagcaaaa taaaatgcag atcatcttgg ttttcttctc gatccacttg tttctctaaa 1804621 tccaaatcat ccctctccct tatccttatc tctgtttcac aatatgtgcg acttcgattt 1804681 atggtatagg ctatgtccac tccattaaaa aatcagcatt ttccttaaat agatgaaaaa 1804741 tagatcaggt acggcgttcg actcatacca aataacagcc ggaagaatat gaataacgtg 1804801 agttcactat cgaataggag gtgtgtgtaa tgagctctga aaatgcacag ttaaaaaagg 1804861 atttaattaa agccgtttta agccctttat ttccaactgc aacagaagga ggagaaaata 1804921 tggatagtaa tcttaaagcc ttgcttgatg ctgccatcga tcaaaaagta gatgaaagtg 1804981 aaacggttac ggcagaatct attttagacc cttctcttcc ggcaagatgg atttttgcca 1805041 gaattacgcc aggcactaca atcagcattg tgactgattc aggtgacatg atcggaccgg 1805101 ttgttttcgt tgctttcgat caggttcacg ggatcgtatt tgtaacacag gaaagctccg 1805161 tcactccggc aggccaagct acaacattaa ttgatgtaga caaagtagaa agcgttacgt 1805221 tcttttcata acatccgatg aaagtcttgt atatccagtc gggatacgga ggaatataca 1805281 gttattttga tcgctgggct gaagaatgtt ttcagaacac tcatacagag tatatgattg 1805341 cagataaacc tgaagcagaa tctttgatga agatcgaagc gtttcagccg gatttcacac 1805401 ttatgatggt tggagaccgc gttcctcacg actggctgac ctggttaaag ggtaaggata 1805461 tccccgtgta tgtttggctg accgaagacc cattttatat ggatatcagc cttcaggtaa 1805521 ttaagcttgc tgacgccata ttaacgatag aacaaaatgc agctctctac tatcaagagc 1805581 tcggctacca gaacgtctat tatgttccga taccagttaa ccatcggctg tttaaaaaaa 1805641 tgggcaccga acattcctat cattcaaatc tgttaatcat cggctatcct taccctaatc 1805701 gggttcagct tatgaaagaa gcggtccatc tgccattcac ggttcgggta atcggcaagg 1805761 aatggggaaa atatctgcct aaaaaagtgc tcaaacagcc gcatattgat gtcgtcagca 1805821 catgggttcc acccgaacag gccgttcatt attataatgg ggcagacatc gtaattaatg 1805881 cgcatcgtcc ctatcatttt gctttcaacc aaaatactat gcgcatcaaa aatgccagtt 1805941 ttaataaccg aacgtttgat atcgctgcat gcgaagcatt tcaattaaca gatttacccg 1806001 cggcgcatcc tttttcatcc attatttctt atcacggcat gaacgacttt aaggaaaaag 1806061 ccgctttcta tatcaaccac cctgaagaac ggcaaaaagc tgcagcagcc aattataaag 1806121 agaccgtacc cgcatttacg tttgatgagc ttcctgcaaa actaaaagcg attcatctgg 1806181 cgctttcttg aaaaatcgtt cattgctatg aacgattttt ttattcatag aaaaaagcag 1806241 ctgcacaagc tgctttctat tctagccgtc agaacggtct ttcagcttcc tcggatttac 1806301 ctgtttatga agatcaggca tttcgccgag atgctgtgca atttgttccc acgatacaat 1806361 tttgaaattt tgattgacgg cttgtccgtt atcaatattt tcgccgtcct gcgccacaaa 1806421 aatcccgtac ggatattttg ggccaagtcc gaaaccgaga acatcaatac catccgtgtc 1806481 actagtaccg tctatcttct cgccatctgt aatctcaaag ttggctacat agcgattttt 1806541 cccctgccgt tcatacattg catagctgtt atttccttga cttgaagcca tgagatatcc 1806601 tttgccattt ggtgcataat agattgtcag tccttcaata tcagctgtca aatgatctcc 1806661 tgtcgcacgg tcaacaacct gcccctttga ccctccgccg ggctcagcgt taaatttcca 1806721 gatggcctca tcttcctctg ctatgtatag gtttccgtac tcatcatccg caacaaggcc 1806781 ttcggtctga gaattcaact taaattcacg cacctttttc cctgttacat aaccctttcc 1806841 accatcaaca atttcatact gctcaaattc cccttgtttg cctgtcacta atgcgtaaaa 1806901 tgctcctgtt ttctggctgt gatacaagct gaatccataa acctcagaaa tattggtgga 1806961 aataggatgg ttcggatctg taatgctttt caattttcct ttatccccgt ctattgcata 1807021 tacttcaatt gtattttttc cttcggaccg gttggatgcg gcagcaatat caattttttc 1807081 gccgttcaat ggaaaatcat agcgcagatc gacattattg agcttgccaa actcataaga 1807141 atgaagctgt tttccgtcta aatcatacac aacgagccct gacttcttat ttgttgtaat 1807201 caacttgctt ttttccgggt gtttttcatg aacccaaatg gccgggtcat ctgctgcatc 1807261 atcgccagat gcgaccggat ctgtctccgt gtgtgcagtc actttgaaat gatgttcctc 1807321 attcacataa tgagccgaca ccgaggttgc tgtcaggcta agcaataaac ccgcggcagt 1807381 gcttagcagc attgtttttg gaaccttcat ttggtaccct cctcttttat cactaacact 1807441 actattgtaa aatatataca ggtgattacc gtgaggaaaa tgaacctttt tttatagggt 1807501 ttctgactca taaacaactt attccccaaa gaggtggtga gatgactttg ccagatttac 1807561 ttttgcggag cgaaataaaa atatgttgaa tatttagtac attatttatt tagttttgtt 1807621 tttccctagt tacgtccgtt tttccatttt ctattaaaaa agaacacttt gtgacatgat 1807681 cattccccta aattttgttt tattggttgc tttcattaat tcgattacaa agttgaacat 1807741 atgatgcatg gtagagaaac gagagttgga ggataagcca tgcctaaaca gcaaacagca 1807801 gaactaaaac catttttcca taacaaaaca gttttagtca ctggcggaac gggttcaatc 1807861 gggagtcaaa ttgtcaaacg ccttttgatg cttacaccta aacaggtgat tgtattcagc 1807921 aaagacgaca gtaaacagta tgtcatgagc caaaagtatg cggaggataa gcggctatta 1807981 tttgtacttg gagatgtacg cgatcacaga agggtgaatc aggtgatgaa aggcgtcgat 1808041 atcgtctttc acgcggctgc gctgaaacag gttccgacat gtgaggacca tccatttgaa 1808101 gcgatccaga ccaatctcat cggcggacaa aatgtggtgg aagctgccct ttcacaccga 1808161 gtgcagcatg tcattaatat cagtacagat aaagctgtat ctcctgtgaa cacaatgggt 1808221 gccaccaagc tgttatctga aaagctgttt catcaagcaa accgccacgt ccaaaacaaa 1808281 ggaaccttgt tttgttcggt ccgctttgga aatgttctcg gttccagagg ttcggtcatc 1808341 cccatattat ttgaacagat gatggagggt gaacctctga ccatcacaga caaaaacatg 1808401 accagatttt tcatgtcaat agacgatgca gctacattga cattacaatc ggctgctatt 1808461 acaaaaggcg gagaaacctt tattttcaaa atggaatcac tgaaacttga agaactgatt 1808521 catgggtttg aagaatatgc atcgcagcac gggctcccgc ggccggctgc agtagaagtg 1808581 ggcaagcgtc caggtgaaaa gcttcacgaa gaattaacat ctccacatga aattgaatca 1808641 ctgtatgaat ggggcaacct ttatgcgatc cttccagagc cggaaaaaca tcctgacttt 1808701 cgcaaagtca atctgcctgg gtatcaatca gatcaagccc cgctcattac gaaagaaaga 1808761 attgctcaga ttattgaaga attgcatcaa gagaaaaagg cataaaaaca agcctgtcta 1808821 tccattaggc aggcctgttt ttaacagttt atttattaaa gagatgcaga tagctttcgt 1808881 atccttcttc ttttagctta tgcttcggaa caaaccgcag cgctgctgaa tttatgcagt 1808941 aacgaagtcc gtttggcccc ggtccgtcat taaatacgtg gccaagatga gaatcagcag 1809001 ttcggcttct tacttctgtg cgaatcatgc cgtggctcgt gtccagtttt tcttccactt 1809061 cttcttcaat cggctttgta aagcttggcc agccgcattg ggaatcaaat ttatctttgg 1809121 atgtaaacaa tggcttgcct gacacaatgt ctacatacaa cccttcttcc ttatgatccc 1809181 aatattcatt ttgaaatggc ggctccgtgc cgttattttg cgttacttca tattgcatgc 1809241 gatttaatga ctttattttt tcttctttat tgtacgccat ttatttagcc ccccaatgct 1809301 cgctgataaa tcccgctcgt ccggaacctg tccggtagcg ctgataatgt gctggattct 1809361 ttttataaaa atgctgatgg tagccttccg cttcatagaa aggttcagct tttaaaatgt 1809421 ccgttacaat cggatcttta aagatgccgc tttccgccag acgttgcttg gaagcttccg 1809481 caagctcctt ttgtttatca ttatgataaa aaatggctgc gcgataggaa ctgccgcgat 1809541 cagcaaattg ccctccggca tctgtcggat cgatttgctg ccaaaataat tcaagcagtt 1809601 tttcataagg gaatacatca ggatgaaacg tgatttgaac ggcttcacga tgtcccgtcg 1809661 tttcactgca cacctcttcg tacgtagggt tttcagtatg gccgcctgta tacccggaca 1809721 ccactttttc aattcccggc tgttcgtcaa aaggtttaac catacaccaa aaacagcctc 1809781 ctgcaaatgt ggcgatttct tttttttcag acatactggt gcctcctttg ttaatacgtg 1809841 gtattattat attatagcat gtaaaaatag aatgaaaatg attctgcttt tcaataaaat 1809901 ctataggttt taagcaatat gcttatgtaa tggaggttca caaatttgaa agtaagaaca 1809961 cagatgatgt acgatatgga aactttactc cgtaaagtct ttaaacaaat acgcaatgaa 1810021 atcaatgaaa ttttagataa agagctgtcg cggaatgaat tcaccattct tcgaatcctt 1810081 agtgaacaag ggcctaaaaa agtcactgaa tttgcgccta ttttagaggt atcggcaagc 1810141 cacattacgg ctgtgaccga tgcgctggta gaaaaggaat ggattacgag aatcagatcg 1810201 aaggaagaca gacgcatcat ccgcattcat atcactgaag cgggcgaaaa agtccttcag 1810261 cactttaacg agaaaaaaac ggaatatttc tttaaacgct ttgactgcta cactgatgct 1810321 gaacttgcca cgttaatcga gctcttcagc aaacttgata aaaaacggtg aaaaaaagca 1810381 cataccgata tataggtatg tgcttttcgc agtgcttcac ttatttttca gtaaacagct 1810441 tcattgcttt ccagcggcca tatctataat acaaaaatgc cgcgcagctg ctaaataaaa 1810501 aactcattcc gattccaagc ccgattcctt tttgtccaag ccaagctgaa aatagagctg 1810561 tgaaaggata cctcaacacc caaaacgaga tcaaatttaa taccagaacc tgcagcatcg 1810621 ctcccgcggc cctgacgatt ccgttcagca caaaattaac cccaataaaa gggtagaaaa 1810681 acgcgatcca cttcaaatat tgttcaccaa atgcgaccgc atcaggctca ctgataaata 1810741 accttatgag gtatttacca aatacccaaa tcataaccgc aatcaccagc atgcaggaaa 1810801 taacagctat cacacctagc cttgcaattg ttcccactct tttttcgttt ccgattccaa 1810861 tattttgccc tgccatacta ttgacggccg taccggcagc cattgctgga agcgtgatga 1810921 tgctatcaag ccgctgcacc gcgccaaagc ctgataccac gtgatccccg tatgagttaa 1810981 caacactcat aatcgccatc ataccgcctg taatcaccat catctgcaga cctgccggaa 1811041 tcccgagttt caaaatcagc gcggactctt cccacttggg cattctcgga atcgagaatg 1811101 gcacaagctt gtgtttgatg acataaaaca acccatacaa aaacgcaatg ccctgtgaca 1811161 aaatcgttga ataagccgct cccgctattc ccatgcggaa cacagaaata aagagcggcg 1811221 caagcactgt attcagtaca acagcaaacg caataaaccg gagaggtgtc ttgctgtcgc 1811281 ccagcgcacg aagcacagta ctgataaagt tataaccaaa caaaaataaa atgccgataa 1811341 attgaatctg taaatacgtc tcagcaagcg gtatcattga ctccggcgtt tttagaagac 1811401 gcagcaaaag ctctgagaga aaaaaaccgg ccgcgccgaa tccgatgctt aggcctgtta 1811461 ataaaacaac aaaagcgtta atatacgacg ccattccttt tatatcatct tttccttttt 1811521 gctgagataa aatggttaac gtcgcattgt taaggcccaa aataaaagac agcacggtca 1811581 aaacaatcgt gcttgatacc gcggctgccc caagggcctt tgcccccagt aaattgccga 1811641 tccacaagct gtctataaat tgaaaggaaa cctgcaatgc gtttccgagc ataataggca 1811701 ttgaaaacag tacaagctgt ttcagcacgt tcccctgtgt aaaatcgtat gctttcatct 1811761 tttctccttg tgttctcaaa ttttcttcgg accacacgaa aaaagagacg ttgtttcatg 1811821 tctctttttt catgacttat cggttttttt tcggtctcgc ataccgaatg taaacaccat 1811881 cacacttagg aacaaggcac aataggaaac attcaaatac atttgatcca tatcttcagc 1811941 agccagatga tgataagcaa gccagccgaa gtacagggaa aatgtaaagg ataataaact 1812001 gaaatactgg taaatccgtt tcattttcag tcacctctat tgtttaggat ggtaatagga 1812061 aaactcaatt tcatcttttt ctaaatttat cttatccgct ttgacataca ttccattcgt 1812121 taaaggcatt tctgacaaac gcacttcaat gcttttatct ccggggtgaa catggacaaa 1812181 tgacggcaat tcataaaagc tgtccatata atttaacaca aagctaattg gtatactcaa 1812241 tttccctaac gaaaatttcg tgacattcag ctctacatca ccgttttttt tcacggtcgg 1812301 ctcaaaagcg ataaacgcat caatagacgt ggaaaatgcc ttgattttcc ctgcgacatg 1812361 aacatcatca tcaatctcta ctttataatc aagcttgttt gatgctttgt cgtttaaata 1812421 tgagttaaca aacgcagcta atgattcttt tgtgcttgtc acttgaaatc catactcgct 1812481 ctcagatgca tctttcacct gagcctgttc ccccggaagc aaaacaagtg ccacaaaccc 1812541 ggcggcgagg ataaaattga ttgcaagcaa tataaaaaac agtcgcttcc acttattcat 1812601 gctgtcaccc tactctttcg gtaatccttc ttttttaatg gcttgataga cgcgctttgc 1812661 gataagagaa taacccgtac cattaggatg aaaatcatct tcctcagaaa ttcggctgct 1812721 gtcacttttt tgattaaaca aatcttcgat atggacgatt tttgcatgtt tatctttttt 1812781 cagctctttt tcagcaatat ggttccaatc cgtgacgaca ccatttattt catttagttc 1812841 tgataatgta aacgtaaacg gattgtacat gctgacataa atcagctcag cgtgatcatt 1812901 cagctcgcga atttcagaaa tgattttttc aaagcgcttt tcgtacggtt tttccgcttc 1812961 ctgaaacggt tcaacggtta attgcagaaa gttttggcga aggattttca tcaaatcatt 1813021 accgccaatt gtaaaaaaga cataatctgc gtcctttatg cctttttgaa cctttttatc 1813081 ttttagtttt tctaataaat catccgaacg gttccctttt acagcataat ttttcacgtc 1813141 gaccgttttg acttgtttat ctgaccggat agaatccgcc accttgccga catatccctt 1813201 tccgtcggga tctccgactc cttctgtcag cgaatctccg acagccgcta tgacaatgtg 1813261 ttcttttgtt ttcgtttcat gggctttttg ttttccctca gatgatgtac gtatgctcgt 1813321 acacgcagta agaagcaaaa tcaaactggc catgattgaa aaaatgcgca gcttcaatct 1813381 tgttgctcct tcccattcta ctagtggaaa gtgtatcatg ttttagaaga tttgcaaatg 1813441 cctagtctct tagcttactt gagtgtactg gctgacttca catcggaaat gatatcatcg 1813501 tacggtgtat tctccactcc attgtaatct ttcagcacct taccgtccgg acctaccaaa 1813561 taaaaagaag attgatgaat cacttggtcc tctccctccg gcttctttac gatcgcttta 1813621 aagctcttaa gtgcgaactc ctcaatctca ctctggctgt atcccgtgag aaaatcccag 1813681 ttatcaaaag ataatggata atttgcggca aatttcttca gctgtttcgg cttatcgttt 1813741 tctggatcaa cactaaatga tatgatgcgg acatctatat tttcggcttt cagttttttt 1813801 tgcagatcgg tcatatgagc ggtcattggc ggacatatag tttcacaatt ggtaaaaata 1813861 aaatccgcca gccatacttc tccttttaaa ctctctaaag aaacgttctt gccgtcttgg 1813921 ttttgaaatg taaaaggctc cacctcgtaa ttgagcggat ctttaatctg ctgtcctccg 1813981 catgcacaca aaaacagaaa aatcagccca gccgttaacc ccttgataac cttcatgaca 1814041 tccatccttt ccagccagca taaaaacgct ttctaaaacc gtccttactg tcccatgttt 1814101 gtattcgata ctgagcaaaa aaaatcctgc atgcctcccc attaacgatt acaaaggagg 1814161 gcatgcaggt aaaaaacggc atgttacgcg ttgtgcttta acacctcttg atgaaataca 1814221 gcctgataat ctgcccactt catccgccgc ttcatataat gtcggaaaga atacactttt 1814281 gccctgctgt ttgatgaaaa cacttctttt aagtagaatt gcaaatggtg atgtaacata 1814341 aagaaatagt gctcatcttc ctttaataca ggtatttctg tcactttcac ctgaatcccg 1814401 tcaccgcgtt tgaactctag gcttttgagt aacaagctat caatcctctt ttttgttttt 1814461 cttctattat atatgatgcc agccgggctg tctgtcattt tgcgcggttg tgtaaaaaaa 1814521 ttagattagc aaatggaaca agtcctcatc cttgttcacc tctacataat gaaacggttt 1814581 tttgttcatc cgttcaatca gcggcccata atcggctttg ttctgcagct cgatgccgac 1814641 aagagcaggt ccattgcttt tattattttt cttcgtatat tcaaaccttg taatgtcatc 1814701 attcggcccg aggacttcgt caagaaattc gcggagcgcc cccgctcttt gtggaaaatt 1814761 gacgataaaa taatgctgaa ggccttcaaa aatcaaggaa cgctccttca tttcctgcat 1814821 tcttccgata tcgttattgc ccccgcttac cacacacacc acgtttttcc ctttaatttg 1814881 atccttgtac aaatcaagcg ctgcgacaga aagagctcca gccggttcag caacaaccgc 1814941 acattcgtta tataattcaa gaatggatgt acatactttt ccttcaggca caaggagaat 1815001 gtcatcaacg acagtttcca gcgtccggaa ggtttcctcg ccaatttttt taacagccgc 1815061 cccatctaca aacttatcaa ttttatcaag tgtgacgaca tgcccagctt tgtttgattc 1815121 aaagtaggat gccgctcccg ccggctcaac agcaattacc tttgtatcag gagacacgtt 1815181 tttcaaatat gtacctaccc cagagagaag gccgccgcct ccgacacttg caaaaagaaa 1815241 atgcggttct gtatcaatgt cgtttaaaat ctcgactgcg agcgttccct gtccggccat 1815301 cacatccgga tcatcgaacg gatggataaa cgtccgagat tccgcctcac agcattcagc 1815361 agcgctttta tacgcgtcgt caaacgtatc gcctgtcaaa ataatatcga taaatccttt 1815421 tccgaatagt tcaacttgag atactttttg tctcggtgta gtagacggca taaaaatttt 1815481 cccgtgaatg ccaagatgtt tacacgaaaa tgccacacct tgagcgtggt ttccggcact 1815541 tgcacacaca actccgttct ctgtctgctc gctggaaagc tgtttcattt tatgataagc 1815601 ccctctgagc ttaaaagatc tgacaacttg caagtcttcg cgttttaaat agatattgca 1815661 ttcatatctc tcagaaagtc tgtcattcct ctgcaaaggt gtgtgaatga caacgtcctt 1815721 tacgttttgg tgagccttca aaatgtcttt cacttggatg agagagtttt ctttaagcaa 1815781 cggtttcatg tacagattcc tttcttgttt taaatcccta tttaatatgc cattataaca 1815841 tgaatattca aaaaataaga caattatttt tatttaataa ttaaaaaaat acagactatg 1815901 tccaccacat cttgtggtaa cttctgttca accattatcc tgcagagcca agaaaaaaga 1815961 tgatcgtaaa ataaagggtg ttttcaacca aaaggcatga tataatgaaa ccaattagaa 1816021 ccaaaaggag ccaattgatg aatagtgcac caaaactcaa tacatttcaa catctaatcg 1816081 gagaacatca aacttttctg gaagcgaagc gaatcgccaa gcagttctcg ttatcggagc 1816141 ttcctgtctt aataacagga aaaatcggaa caggcaaaaa tcacttcgca catgccatac 1816201 acttggaatc ttcgagaagc aatgaaccgt ttataagcgt caattgcagc acccattcgg 1816261 aagaaaccct tattcatgag ctttttggcc ctaacggaaa cacaggtgtt tttcaaaaag 1816321 cggtacgagg aacccttttt cttgatgatg tatggcgcat gcctgcttct gtacaagctc 1816381 agctgttaaa agcgcttgat tcagacacgg agaaaccgcg aatgatctgt gcttctgcag 1816441 accgatccgt ggaacataca ttcaggcaag acttattcta cagactgaac attttaacgc 1816501 tcacactgcc cgaattatcg gaacgaaaaa gcgatattcc gcttttgaca cagcattttc 1816561 tctcaaattc tggtcagcaa ttgttaatcg atccctccgt ttttcccgtg cttgagaagc 1816621 atgcatttga aggcaatgtc agggaattaa aaaacgctgc agattatatg gcggcagtat 1816681 caagcggggg aacgattcag ccatatgacc tgccgccgta tattagaggc acgatagacg 1816741 gaaaaacgtc gaagaaaaaa gcgaaactgc ttactttaat ggaaaaagct gagtttttgt 1816801 ttattttgga aacaataaaa gtattgaacg aaaaaggaga acctgccagc agacggatca 1816861 tttctgaaca cagcaaaaat acccaaacct cgttaactcc tcagcaggtc agaagccgtc 1816921 tcgactattt ggagaaaaaa gattatgtca ccaaaagccg cggacgcgca ggcacaaaaa 1816981 ttacctttga gggcttgagc tttatagaga cgttaaaaaa tcaaatgatc tagcgatcga 1817041 aaggagaatg tacttgttta caatcaaaga agagatcgcc aatgcgatta cacacggcat 1817101 cggtgtcctc ttatccatcc cagcattagt gtttctaatc atatttgcgg ctaattacgg 1817161 gtctgcatgg gacattgtca gctttacaat attcggtgtc tctatgctgc tgttatattt 1817221 gagctccacc ctgcttcaca gcatcacaca taaaaaaacg aaggacattt tggagattat 1817281 tgatcatagc gcaatttacg tactcatcgc cggaacctac acgccttttt tgcttgggcc 1817341 gctgaaaggc acactcggct ttaccctgtt ggttatcgta tggtcacttg ccctaggcgg 1817401 aatcgttttt aaaattttct ttgtgaaacg gtttatccta ttgtcaacct tcgtgtattt 1817461 agtcatgggg tggctgatga ttattgcagt taaaccttta tatgcttcac tgagcggagc 1817521 gggattcagc ctcctttttc tcggcggcat tttatactct gtcggaacca tcttttacat 1817581 ttggaaaaag atccccttcc atcacgccat ttggcacagc tttgtattgg gcgggagcgc 1817641 tgccatgttt ttctgcgtgc tcttctattg tgtaaaggtg cctttccttt cgtaacagta 1817701 acagaaaagc gcagtcttca cgactgcgct tttttatgca cgtaattgtt tttcattggc 1817761 aggtatataa gcttttgaaa aggacaattc aatgtctgcc ggttttaagc gtttaaaaaa 1817821 cgagccattt tgcatgttat ctgttccttt cgtttccacc atcaccaacg gaagatgata 1817881 gcgggccgca agttctacag gatcaataga accatctagt gaaagaatca ggctttgtcc 1817941 cttttccagc tgttttgtca catcttcata taccttttct gaatccccgt ctgaaatcac 1818001 atccatccga tccagccatt gcccgataaa aggcaagcgg aacacttttg ggttagcgat 1818061 aaagccggcc ggttcctcaa tatatccagc aattaaggcc agttcagcca aacgcaaacg 1818121 gggatgcaca tacaaaacag gaccgtgtgg tattggctct ggctgatgga tcgtcacaac 1818181 tgaaccggag atgccgatac agccttctaa aaacgccttt ggctgttcgt acacaagagc 1818241 catctgtttt ttgtatgaca gacggggatc gagcattgtt tgattaaata attgtttcat 1818301 attttttaac agcatataca caatataaac cactagaagg ctgtagcgaa ccaattaaaa 1818361 tcctcccgct ttagaagaat tctttttttc atacattaga aattcgtaat catacgggtt 1818421 tttttcgtct ttggtcccct gctcagaaga aaccagcttc caattggatt catcaaattc 1818481 aggaaagtga cggtcaccct caaactcgtg atgaattttc gtcatataca gtctgtccgc 1818541 ataagggaac aggtccgtat agagctgagc ccctccgatc acaaagcatt cttcagggcc 1818601 tgaacaaatg tccagtacat cctttaatga actgacaacc gtgcatccct gaaattctga 1818661 atccggcgct gaggtaacga caatattttt ccgatttgga agcggacgtc cgatcgattc 1818721 aaatgttttc cggcccataa tgattgaatg gcccgatgtt attttcttaa agtatgcaag 1818781 atcattgggc aaatgccacg gcaaatcatt gtctttgccg ataagcctgt tggcatccat 1818841 cgcaaaaatg aatgaaatca tacgctgacc gcccctttta tatgaggatg cggatcataa 1818901 tcctcgatga taaagtcctc aaatgcaaag ttaaaaatag aatcaacctt tctggcgaaa 1818961 cgaagctgcg gaagcggtct aacatctctt tccagctgca aattgacttg ttcaatatga 1819021 ttttggtaaa tatgaacatc accaaacgta tggatgaact cgcccggttc aagcccagtc 1819081 acatgagcaa tgatcatggt taggagggca taagatgcaa tattaaacgg cacacctaag 1819141 aaaacatcgg cagagcgctg atacagctga caggacagct tgccgtcaga cacatagaat 1819201 tggaacaggc aatggcacgg cggcaacgcc attttatcaa tttcaccaac attccaggcg 1819261 ctgacgatta agcgtctgga gttcggattt gttttaatat cttcaataag acgggaaatt 1819321 tgatcaatgg tttctccatc agctccccgc caagaacgcc attgggagcc atatacaggt 1819381 ccaagttcac cgttttcatc agcccactca ttccagattc gcactccgtt ttcctgcaga 1819441 tagcgtacat tcgtatctcc ttttaagaac cacagcagtt catgcgcaat tgatttaaag 1819501 tggagttttt tagtggtgag catcggaaag ccttcccgta aattaaatct catttgatat 1819561 ccgaaagtgc tgattgttcc ggtcccagtc cggtctccct ttttctcacc atgctctaaa 1819621 acatgtctgc agaaatcctt atactgtttc atttttttca tcctttaaaa gtagtcttct 1819681 agtagtgtaa cacaataaaa aatcatttct gaacccagaa atgatttttt tatagtcagc 1819741 tgacgacagg cttttcatcc tgttcttttt cttcatcttg cagatcctga tgcgtatgtg 1819801 caattctgct cgccgctgct gcagcaagag ctgccacaat atcatccaaa aaggtgtgaa 1819861 taccgtctgg actttcatca agttccttaa taattccaat cttctcttta tccaaataac 1819921 cgaaattggt caaaccgatc gacccgtaca cattaacgat tgaaagcggg ataatttcat 1819981 ctatgccgta aagcggttca tccgtttcaa caaggtgctg cagcggttcg gggagaagtt 1820041 tctgttctgc aagctgatcg agtgcaaggc ctgtcaaaac agcatgaata atttcacgtt 1820101 tgttcaggac tttttctaca ttctccatgc aaacactgag cggcagattt ggattgtatt 1820161 tttcctgaag tttttgaaca atccgtgcaa tatcttctat cataacgccc cgtttgttca 1820221 gcatatcctt tgttatatcg accatttcat tcattgtgta ctttttcatg tctaatggca 1820281 tctcctttag gcactcatcc agttgggagg cgtgttgcgg tcccagtaaa tgctcccaag 1820341 ctcatgatgt gattgaaatc catcttctgc tgtatgataa tgaaaattaa accagtagcc 1820401 gtcatgaggc gggtggtctc ttcgcacatg gaatctgaga agatcttctc cagttgtccg 1820461 attgtaaacg ttgaaaattt tttccgtttt gcccgctgaa ggcatgcttg agatcacaac 1820521 atcttggtac gcctcatcat cttgcaatgt cgctaaataa tcactaatca cattttcgat 1820581 ttttggcagg atctctttcc gatagtcatc ctcaatgaca ggagcgattc tgctgccgaa 1820641 ttttaaaaag gactgatcct cagcgctgtc aaggagctgt tccttgtacg attgaaaaag 1820701 cagttcagga tctcgcctgt catccgactc atcatcgtac aggtcatgct catcataaaa 1820761 agcggtgtaa tcattctgct caagactgct cggctgtccg gaaggcttgt ccgccataag 1820821 ggcagccgga ggagatacga gcccgaacgt tacaatggta aataaaacca caagggtctt 1820881 tctcatccac aatttcatga ctgcttattc ctctctattt tattgtcatg tttctcttat 1820941 tttagcacat ccaaaacatg caagtcatgt actatatgaa actgatatgc aaattaggag 1821001 attcgttgct atgcactttg tgtaaaaacg cttacaatat ttcatgaaag gaggctttcc 1821061 gcatgattga cgctctgttt gccacagttt cactcttaac attattatac tttgtcgtca 1821121 tggaggtcac cgattaacag aaagcccgtg atatgaatca cgggcttgtt tgaatgacgc 1821181 cataatggaa cagtgctgtt tttcttttca tgacgttaaa accaaactgt tcaaaccgcg 1821241 ggcttttcca gtggtctttt agcacaacgc tttttctggc gactcgtacc gcttcattga 1821301 tacatccttc gtgcaaaacg gaatcctctg ccaaatcacg taaaggcgcg atgccgtcag 1821361 aggtttctac aggttcatga aacattggat cgaaataaac cacatcaaca gagttgtcag 1821421 ggagctgctt gatgtgttca aagcaatcac cattcttcac ctggattctt ctcatcgcag 1821481 cttgaagctc ttctataccc gtttcccatg aatgcagccc cgtcctcact aaaacagaca 1821541 caagatggtt tttttcaatc ccaacaacag aacccgtttc gcctactgcc atacttgcga 1821601 taatggcatc tgaccccaac ccgagtgtgc aatctaaaaa cgtatcccct tcagataagc 1821661 cggcagcccg aagcataggt tctttctccc cctgtaagaa gcgtttggct ctgaacatcg 1821721 ctgtattcgg atgaaaaaag aatttggcac cttgtttcgt atacagctca aaccgctctt 1821781 tgccgaccac aagcaaatca cgttcagctg atttcagcag gtgctcaacc gtttgtttat 1821841 tccggccgca gtatggcata tttagctctt tagaaagctg ctttgcagtt tttatggtgt 1821901 gttcagacgg tctatagctt gttgttatca tcttctgtac tcccaaaaag aaaatgcccg 1821961 gagaacgggc atttagcagt gcgcatcgaa ggcagcagtc agatttttca tgatttcttc 1822021 catatcgtgt ccttcaattt catgacgcgg aataaaatgt acgacttctt tgcctttcaa 1822081 aagagccatt gatggtgaag aaggctcctg gccagtaaaa tactcacgca ttttcgcagt 1822141 agcttcttta tcttggcccg caaatacagt caccgtattg tcaggtgttt tgtcattctg 1822201 gaggactgcc tgtgtagccg caggacgcgc aaggcctgcc gcgcagccgc atacagagtt 1822261 aacgactaca agagttgtgc cctctgcctt ttccataaag ttttctactt cttccgctgt 1822321 tgttaactct tcaaaacctg ctccagtcag ctcgcggcgc atcggtacga caagctggcg 1822381 catgtattct tcataagcca ttgacataaa aaaagccccc tctagtatcc ttcatctgaa 1822441 gtaaaggata ctatagagag ggccggattt caaatgttca cgccttaaaa taaaagaaag 1822501 tgtccccagc tatctagatt ttcataatac cgccggtgtt ggcacttgtc acaagtttag 1822561 aataacgtgc caggtagccg gttttcactt tcggttcaaa acctttccag ttcgcttttc 1822621 gtttttccca ctcttcttct ggcacttgta catccaagat gcgtttttca atatcaacga 1822681 taatatggtc tccgttttca acaaaggcaa gcggcccgcc ctcagcggcc tcaggtgata 1822741 cgtggccgat tgagaggcca cgggaggctc cggaaaaacg tccgtccgta atcaatgcca 1822801 cttttggccc gagtcccatt ccaacgattt gggatgttgg cgccagcatt tccggcatgc 1822861 caggtccgcc ttttggccct tcgtatctga tgatgacaac gtcgccttct tttacttttc 1822921 ggttgataat gccgtcaagc gcctcgtcct gagaatcgaa tacgacagcc ggcccttcgt 1822981 gtcttgtaat cccattctgt acgccgcctg ttttaatgat agcgccgtcc ggagctagat 1823041 taccgaataa aacagcaagg cctccctttt cagtgaatgg ttgatccagc gggtgaatga 1823101 cgtcataatc ctttacttca tgtccggcaa tggtttctcc aagagttttt cctgtaacag 1823161 tcagcgcatc taaatgaagc gctccttctt tcttcgaaag ctcattcaga gccgctgaaa 1823221 cgccgcccgc ttcgtgaaga tcttcaataa acacatccga tgcaggcgcc agcttagcca 1823281 agtgcggcac gcgctcagcg acttcgttaa tgcgttctaa agagtattca acgccggctt 1823341 cgtttgcaag ggcaagggta tgaagaacgg tatttgtaga acctccgagc gccatatcga 1823401 gtgcaaacgc gttatcaatc gcttttactg taacaatatc acgcggtttg atatctttgc 1823461 gaatcgtttc cattaattgc gcagccgatt ttctcacaaa ctctttgcgt tccggagatg 1823521 ttgccagaat ggttccatta cccggcaaag caagaccaag tgcttctgac agacagttca 1823581 ttgagttcgc cgtaaacatg cctgagcaag acccgcacgt tgggcatccg aactgctcta 1823641 gttcttgaag ctcgttttcg ttgattttcc ctgcttggta ggcgcctacc ccttcgaata 1823701 ctgaggaaag ggagattttt cgcccgtcac ttgttcttcc tgccgccatc ggtccgccgc 1823761 tgacaaaaat cgtcggaatg ttgatgcgca ttgccgccat aagcattccc ggtgtgattt 1823821 tgtcgcagtt cggaatacag accattccgt caaaccagtg tgcggataca accgtttcca 1823881 cagagtctgc gataatttca cggcttggca gcgaatatct cataccgata tgccccattg 1823941 cgatgccatc atctacccca atggtattaa attcaaacgg aacgccccct gcttctctga 1824001 ttgcttcttt tacgattttc ccaaactcct gcaagtgaac atgaccggga acgatatcaa 1824061 tgtatgaatt acacaccgca ataaacggct tgccgaaatc ctcttctttt acccctgctg 1824121 cacgaagcaa actgcggtgc ggagctctat cgattccttg tgtgatcata ttactgcgta 1824181 attctgccat ggtgatcctc ctaaattctt tcaattgttt gattggattt tattttgaca 1824241 attttcagtt tatttatggg ctgtttttgc aaataagata aatacaggcc gccctcacct 1824301 tgttttgttc tttcgtgttt ttatatttat atagctttct ttcgatttga accctccaac 1824361 tattaatatt gttacttact ataaatagtt ttcggatatt tttcaacaat attcgaaata 1824421 atttttataa aaagtgaatt cacataaaaa aggtgcatga tctgcacctt ttttatcttt 1824481 attcgccttt ttttctgctt tccgtcattt gtttccaaac agaacctttt gcttcttctc 1824541 catgctcaat acgttcaagc gccattttga cttgaaggct gacctcaaat tcggggtcat 1824601 cttcggcagc gcgcaaagct tcaattgcac tttcatcgcc gacttcgtac aggaacatgg 1824661 cggcacgcca gcgaacaagc ttgctggagt cgcttaatga cttgatcata gcaggaatgg 1824721 cttgaggatc gccgatatca gacaggcagt ctccggccgt tcttctgact gatacagctt 1824781 tgtcctcaag tgctttatac aatagaggaa gaacatcagg tgtttcaatc attcctaagt 1824841 acacaacagc ctgtcttctg atggacacct ttggatcatc caatgccttc tgtaaaaccg 1824901 ggatatcctc ttctttcgga tccatctgtt ccaagtgtgc ataacgcttt ttccagtcct 1824961 catcatccag catatcaagc gttactttat acgctttgcg ctgtacagct tgttttgctt 1825021 cgccctttcc ttgagcggct gcttcagtca gtcgtttcag ccgttcatca ctgtatgccg 1825081 cttgaagctc ttctgtcaca tcatggccga tttcatcaaa gtcaccgaat ctgacacctt 1825141 gttctttcca agcccgctca aacacaacat tggaagcttc agatctaagt tttaagatcg 1825201 cctgctgaaa gcgttcaggt aagccgaagc gttcttcccg ctctccatcg gttaatttaa 1825261 cttgcatagg aatgccgctg aacatctgca caaaaacttt tacctctcca aaagattctt 1825321 gatcagaacg attttcttct gcgctttcag cactttccat cccaaatgca gtgcggactt 1825381 gcggtaaaat gtctttccag tcgtatcttg cattccgttc aacagcaaga aaatctgcga 1825441 cgtgatatac ccctttaact ccatctattt taaggatttc cgctataaca agcggtgcgc 1825501 cttctgcttg ctcaggttta tagttattgc ttttgcccgc cggaagctct tccgttaaga 1825561 tgactttcat tgtattcggg cttggtgtag gttcaattga ttttatcttc atgatcgtcc 1825621 tcctatagca tatctgtgac ttattctatc atagtcgctc caagccttct attacgacgt 1825681 ttcggcatca atcccgggta tgtctttttc taattggcgg acaaattgaa gcataaaatt 1825741 gtgtctttct tctgccagtt cccgtgcagt gtctgtattc atcatatctt tcagccgcag 1825801 cagcttatga aaaaaatgag cgtaggcgct ttgctcatct ccataaaggc catgcccttt 1825861 tgcgcccgca aacatgaaag ctctcgcaat gccgacagca ccaatcgcat caagtctgtc 1825921 agcatcctgt acagcttttc cttcaattga gagcggctcc ttcgccaatt tccccctgtc 1825981 ccgaaaggac atccttgtta taatatgaat caccctgtca gcattctctt ttcctactcc 1826041 gaaaaaaacg agctgatcat atacttcgct cacagaaagc ctgaccgtgt caggcagctt 1826101 cacatcaatt aaatcatgaa ccaaagccgc cgtttcaaca atgaacaaat ccgctttttc 1826161 cttttctcca atatacgctg caagatctgc tactcttgat acatgatgcc agtcatgtcc 1826221 agagctttcg tcagtcagga tagattgaac ccatgtcctg atttgctctg cctgcttcaa 1826281 ttccttcaca aaaacaccct ctttttattg ctctaatagc ttcacgatat cgtcttccaa 1826341 ctctttcgga tttgtatttg gtgaataacg gccaacgatt tctccatttc tatccactat 1826401 aaatttcgtg aaattccact tgatcgcctt agttcccagc atccctttcg catgttctgt 1826461 caaatacaca aacagcgggt gggcgttttt cccgtttaca tccacttttg aaaacatagg 1826521 aaatgtaaca ccgtaatttg tttcacaaaa ttcctgtatg tcagcctctt caccaggctc 1826581 ttggttcatg aattgattgc aggggaaccc taagatctcc agcccctcct gctgatatgt 1826641 atcatataat tcctgcagct gcttcaattg ggaagtaaaa ccgcacttac ttgctgtatt 1826701 cacgatcatc agtacctttc ccgcgaaagg ctgaagtgtc atgtctttcc ctgtgattgt 1826761 acgtaccttc atatgataaa tagacatgta agtccctcct atgtccttgg tgctgattat 1826821 tttacctttt ttaaatcgca attcaaaatg taaacatcaa ttaagaactc ataagaaacc 1826881 taacgatatg agcgtcagtt cattatcaat tcatatggct cgttttttat cttatcattc 1826941 tataaaacat tacaattccc tcttacatct ttgaaaatca ttttactgtg aaaccaaaag 1827001 gcgtgtcagt gcgttttatt taaagagttt tctgttgttt ccccctcaac acgtatagat 1827061 agattgaaaa ttggcgtgaa aattcctata atgaagaaaa ttaaacgggg aaataatgga 1827121 ggtggcacgt tgcctattaa tataccaaca cacctgccgg caaaacaggt gcttgaaagt 1827181 gaacatatat ttgtaatgga tgaaagcaga gcatttcatc aggatatccg gccgcaaaaa 1827241 attattatat taaatttgat gccgaaaaaa atccaaacag agactcagct tctcagattg 1827301 cttggaaatt cgcctttaca ggttcatttc acatttttaa tcccaagcac acacacgccg 1827361 aaaaatactg cgagagaaca ccttgacgaa ttttacacga ctttttccaa tatccgtcac 1827421 aagaggtttg acggcatgat tatcaccggt gcgccgatcg agcatttggc gtttgaagag 1827481 gtttcatatt gggaagagct caaggaaatc atggagtgga gcaaaacaaa tgtcacttca 1827541 accttgcata tttgctgggg tgctcaagca ggtttgtatt accattacgg tgtggaaaaa 1827601 attcaaatgc cgaaaaaaat cttcggtgtg ttcgaacata ccgttctttc aaaacacgaa 1827661 agattggtaa gaggttttga cgagctatac tacgtgccgc attcccggca tacagatata 1827721 aatatggaac agcttcaagc agtgcccgag ttaaacattc ttaccgcatc aaaggaagcc 1827781 ggggtttgct taattgtgtc taaagacgaa aaacaagtct ttttgacagg gcaccctgaa 1827841 tatgatacaa atacgcttct tcaagagtat gaaagagatt tggaacgaaa cctttctact 1827901 gtcgaggccc ctaaacatta ttttgcaaaa ggcagcaacg agccagtgaa tcgctggaaa 1827961 gcgcatgcca cattattgtt tatgaattgg ctgaattatt acgtttacca agaaactcct 1828021 tatgaatggg actaattttt ctttttttag tgatacgctg agcaaaaaat atgataaaat 1828081 acatctgatt cagtctgcgt ataacaaaaa tttaaaatac tggaatccaa atcatttaaa 1828141 attagcttaa ctttttcact gcattaataa ttcgattatg tatttgtgtt atgtttatgt 1828201 atagacaata actccttacg atgcatgaag cttgcttgtt gttgattaca ttgaggtgaa 1828261 tttacttgaa taccaataaa agagtattaa ttttgactgc aaattacgga aatggacatg 1828321 tgcaggtagc caaaacactt tatgaacaat gtgtacggct cggctttcag catgtaacag 1828381 tttctaattt gtaccaagag tcaaatccga ttgtttcaga ggtaactcaa tacctttatt 1828441 taaaaagctt ctcaatcggg aaacagtttt atcgtttgtt ttattacgga gttgacaaaa 1828501 tctataataa acgtaaattc aatatttact ttaaaatggg taataaaaga ttgggcgaac 1828561 ttgtcgatga acatcagccc gatattatta ttaatacatt tccgatgatc gtcgtgccgg 1828621 aatacagacg ccgaactgga agagtcattc ctaccttcaa cgttatgact gatttttgtc 1828681 ttcataaaat ttgggttcac gaaaacgtgg ataaatatta tgtggcgaca gattacgtga 1828741 aggaaaaact gctggagatc ggcactcatc caagcaatgt aaaaatcaca ggaattccaa 1828801 tcaggccgca atttgaagaa tccatgcctg ttggcccgat atataaaaag tacaatcttt 1828861 caccaaacaa aaaagtgctt ctgatcatgg caggtgctca cggtgtatta aagaacgtaa 1828921 aagagctgtg cgaaaacctt gtcaaggatg accaagtgca agtagttgtc gtgtgcggga 1828981 aaaatacggc tttaaaagaa tctttgagtg cgcttgaagc ggaaaatggt gacaaattaa 1829041 aagttctggg ctatgtggag cgcattgatg agctatttcg gatcacagat tgcatgatta 1829101 ccaagcccgg cggcattact ttgacagaag ccacagccat tggagtgcct gtcattctgt 1829161 acaaacccgt gcctggccag gaaaaagaaa atgcaaactt ctttgaagac cgcggagctg 1829221 ccatcgttgt gaaccgtcat gaagagattc tcgagtcagt cacttccctt cttgcagatg 1829281 aagatacctt gcatcgcatg aagaaaaaca ttaaggacct tcatttagca aactcctctg 1829341 aagtgatttt agaggatatc ctgaaggaat cagaaatgat gaccgccaaa caaaaagcca 1829401 aagtgctatc gtaatggcgt acttgagagc atacgaaaat cgtgtgctct ttttatttat 1829461 attcagccat caataaaagc ggttacattt ttttatggaa cttgcccttc ttttgaaaaa 1829521 taagccgttt cgcaacttga cgggtgctcc cagatggtgt atagttgaac catcatttaa 1829581 caatgaatca aagttagatg atgacaaaat tttttttagc acatgggtgc tacagtacta 1829641 ggaggaatta agcaatatgc aaaacggtaa agtaaaatgg ttcaacaacg aaaaaggatt 1829701 cggcttcatt gaagttgaag gcggagacga tgtatttgtt cacttcacag ctatcgaagg 1829761 agatggatac aaatcattag aagaaggaca agaagtttct tttgaaattg tcgaaggtaa 1829821 tcgtggacct caagcttcta atgttgtaaa actctaaact caatacatga tgatgagatg 1829881 acaaatagag gagaggcatt cgcctctcct atttgatttt catctggatt tcaatcgcca 1829941 aaatgttttg tttacacctc tgttcaatct cttcaacata cttttccatt gatggttttc 1830001 cttttttcgc gatatcggcc agttcttcta aatcactgta tatttctata aatgttttgt 1830061 gaaggatcaa cttcaagtct ttatcatcca tagctgcgtt ccccttctct atcaagatac 1830121 ctcaaatagt aaaacggtcc tatttattct ggttcaatag ttatatcggc ttatttttat 1830181 tttcttttct attttggtac ataaatttca aaaaaactct gcaaaataat ggcggaggtg 1830241 ttttttgtga cttcagaatt tcataatgag gatcagaccg gctttacgga taagcggcag 1830301 ctggaactag cggtggaaac agcgcagaaa acaacaggag ccgcgacgag aggccaaagc 1830361 aaaacattag tcgactctgc ataccaagcc attgaggatg ctagagaact gtcacaatct 1830421 gaagagctgg cagctctcga tgatcctgaa tttgtaaagc agcaacagca gctgctagat 1830481 gacagcgagc atcagctgga tgaattcaaa gaataaaaac cgcagcttct gcggttttta 1830541 tttttagtga ttggttaaga catctccgta ttgtttcaac ttttcaccaa ccgtacattt 1830601 attgatacaa aatgaatgcg cataagtttt gccaaattct ttgcgaaact gcttcttaat 1830661 aaaacagtcc ttgcaatatt catcgtgcag ttctgtcagt tctttaaaga tcattttctt 1830721 atccaatatc gtcatctccg ttacggtcta atttcgtgtg gctttctacg aattgatggg 1830781 atagaatttt tttagcgagg ccgtcagctt cctgattgtc ttttcgttgt attgtttcgt 1830841 aggttggagt aagcttcagc gattcaagga gtgcttctat tttgtccagc cattcattat 1830901 gagatggatc ataacaaggc cagctgccgt caagctgatt cagcacaaca agcgagtccc 1830961 ctttgattgt aattgaattt ctgcttgccc caagctctct tacttctctt attgcttcat 1831021 aaagcgctgc gtattcagct tcattattgg ttttcagccg gaagctttta ttttttctca 1831081 agcgatgccg ggttcctccc aatgaataat agatgacgat cccgagaccg gccagttcgc 1831141 tctctttatc gaaactgccg tcaaaataaa cagtaatgtc atcaggctct tgagcaagct 1831201 cctctgtcag cttttccaat tccttcagcg tccagctgcc gcctttctcg tcttcgaact 1831261 ctagctcctt catgtatgga aaacggccaa gttctctggc gaacgtacgt gcctgctgtg 1831321 ctgtcagcca gtcttcgcta aaaaatgaga cggatcccgt tccttttgct tctattttca 1831381 aatgcggtct gagcttcatt acaatcacct taccattcat tagttgccgg gcttatgcta 1831441 taatcaaacc aatcttaccc cggaaaggaa gctttttcat cttgtttaat aattcgtttt 1831501 ggatcttttt tgcgatcatt cattttatca ttgttctttt attttataaa ggatttggca 1831561 aaatgggact gtttgtttgg atcggttttg cgacagtctg cgccaacctc caagtcgtca 1831621 aaacagtcga actgtttggc ttaacagcga cactcgggaa tgtgatgtat ggcacaatct 1831681 tttttgcgac agatgtgctg aatgaaaaat acggaccagc tgaagccaga aaagcggtat 1831741 ggctcggatt ctcaacgctc ctgacgctga catttgtcat gcagggcgtg ctgcttttcg 1831801 aaccggcttc cagcgacata tcacaaacag cgctggaaac gatcttcgga ttccttccgc 1831861 gagttgcgtt aggaagtctg cttgccttta tcttcagcca aacgctggat gtttatgtat 1831921 attcggcaat tagaaggata tttccttctg atcggctttt atggctcaga aacggcggca 1831981 gtacagcagt cagccagttg tttgatacat tcatattcac tgcagtcgcc tttctcggca 1832041 tttatccggc agacgtgtgg cttcatattt ttatttctac atatttgatt aagtttgcgg 1832101 tatctttaat ttcattgcct tatgcctatg cagccaaaaa aatgatacct aatgatgaaa 1832161 ggagttcata atgcctacag aaatatatgt agacggcgca agcgccggta atccagggcc 1832221 ttccggtatc ggcattttta tcaaacatga gggaaaagca gaatctttct ctattccaat 1832281 cggagtgcat acaaaccagg aagcggaatt tcttgcatta attgaaggga tgaagctatg 1832341 tgcaacgcgc gggtatcaat cagtttcctt tcgaaccgat tcagatattg tggaacgcgc 1832401 cactgagctt gaaatggtta aaaatataac gtttcaaccg tttgtagaag agatcatccg 1832461 attaaaagcg gcattccctc tttttttcat caaatggata ccgggcaagc aaaaccaaaa 1832521 agccgatctt ctggcaaaag aagcgattcg gctgaatgaa aagaattaaa tcttgatcat 1832581 tggttcatcc taatggcgag gtgaactaac atgaaaaaga aagataaagg ccggctgacc 1832641 ggcggtgtta ctccgcaagg cgacctggaa ggcaatacac ataatgaccc taaaacagag 1832701 cttgaggaga gagcaaaaaa aagcaataca aaacgctaga gaggatctaa acgatctctc 1832761 tagcgttcag cttttcaagc atacgctcaa ttcctttaat ttggtggcgg cgaagcatgt 1832821 cagccgcctg ctccatttgc aaagtaaata aagcgtcttt cagtgtgcag gccagcggca 1832881 ctgagcaatg gatttccgca agcttcctcg acatctccaa atcgcttaaa ccttgctgaa 1832941 tttttccctg ctgtcctttt ggaagaagag aaagattttc caataaacgg tcaatcgttt 1833001 cgtattcacg aatcagtttg taggctgttt tttctccaat gcctttgact ccgggatagt 1833061 tatcactgga atcacccata agcgctttaa tatcaatcaa agccttcggc attacgcctg 1833121 tttcttcata aaaagtctct tttgtataga ctttataatt tccgattcct ttttgaagca 1833181 aagcaacgct tactttatcc gttaacagct gaagtaaatc tctgtcccct gttaccaccg 1833241 taatgtccgc ttcattcgca aataaatcgg caagagtacc gatacagtca tccgcttcat 1833301 agccggcaaa gccaatattc atgattccaa gctctgcggc tgcttccttt gccaaatcaa 1833361 actgcggaat cagctccaca ggcggcgcgc tgcggttggc cttataatct tggaacaagt 1833421 catttcggta cgttttgctc cccatgtccc agcagcagac gacgtgtgtc ggctggaatg 1833481 tttccacagc tgtaatcaaa tgctttaaaa agccgttgac gccgttcgtc ggcaccccgc 1833541 tgtcatttat cataaagttg cgatgtacgg ccgtggcaaa aaaggcccgg aataaaagag 1833601 ccatgccgtc aaccagcaat agtttattat tattcatcaa ataactccct tttctttcat 1833661 tccttctatt ttatcataaa gcagcccaaa aataaaaaac agtatctctt taattagaga 1833721 tactgtttga atatttatca atcgttgtgt cttttgttgc tggcgatcag cttttcagct 1833781 tcgcgtcctg cgtaagagtc aaaatgggtt tgaaatccgt ttttcttttt ggcgttgtta 1833841 ttcgcctgtg catttctgtt tccgagcttt gttctgccca acatgaatcc ccccttacgt 1833901 cggatgcata tagtatatgc ttccggcagg aggttcactc gcgacaggat catccagctt 1833961 acatgcggct tacgtattct ctgaccattt cttttgatac aagccgtctt gtcgggacga 1834021 tgcctttttt agcgagctga ttcatttgct cggtaatttc attaattgca tctgtagtat 1834081 aaggctcatc gtttctgcat ttagcaacag cttcttcaat cgccaattca cgcatatttt 1834141 caagacgcat aaatgctttg atatgctcgt gctgttttga tgaatgtgct gaaattgctt 1834201 tatgtacctc tgacattaat cgttcatctc gcttttttct atttagtcta tcatgacttg 1834261 aaatacaagc caactgaatt ttacattttt attgtattgt ctgaattttt ccaggagatg 1834321 cacgcctgat acgccatttc aatctctttc gcatgttccc cttccgcata tcctcttaaa 1834381 tatgtctctt tttgatccgt tatttgcgcg attgcttttt cacccatatc ttcctgtaag 1834441 cgtctgaggt gagcagtgta atgagatatc aggctttctt cttcattttt tatccatgcc 1834501 tctgtgattt tcgtaagttt catccgtaca gcttcgataa aggtcgcttt tcctttctgc 1834561 tcaaaaaact gcttcggtga tttgatctct tttagttcct gctcaaaagc acgttcttct 1834621 atttccggtt caacttcctt caactgtatg ccgttcgaat gctgatcacc cgcataaacg 1834681 gaaaaataac cgtcctcgtt taatgttttt tgaaaatgat ccagccattc ttcattgata 1834741 tgccgttcga tgaaaccgct catgcgaaca tcaagcgttt tgatttcctg aatatattca 1834801 aatagatatt catgtaaggc tgttgtcatc gctttactga cgttcttttt ccaatccccg 1834861 ttttgcagcc cgggatgaaa tgccgatttt aataaatcat ttgcaaaata tgataatcgc 1834921 tgtgcaatgt gatatagctg ctctcttgta tcttttttta ctttttcaat gatggttttt 1834981 gagttccgcc gtttctcgat atcggccgct gtccgctcaa atgacagcat aaggcactgt 1835041 ttctgcgctt ccttctcttc tcgggactga tgctgggatt ggtgaagctg aaaaacagtt 1835101 tcgcatagtt tgtctgcctc cgaactgagc tgcgctgctg acgctttttt tacatccact 1835161 tcgataaacc ggtctaagtg ttttcttact ttcgagaact gattataaaa tgactccggt 1835221 tttcccacca gttcctcctt acttgatacg gtaaagagct gcggctcata aaccccttct 1835281 tttacaagct ctgcgctgac ataatcggtc actgtttcga gctctgtttt atcttttgca 1835341 aggtctgcag cattaataat aaaaaacatt ttatccatgc tgagcgattc tttcacaagt 1835401 ccaagctttc gcaaaaatga acggtctcct tttgaaaaag agtgctgata ataagtcata 1835461 taaaaaaatg catcagcatc tttgatatat tggaatgcca gttctgtatg ccgtttattc 1835521 atgctgctcg cgccgggtgt atcaacgatc gtaatccctt tttcagtgag cgggcatgta 1835581 tagtagaccg ttacctcttt cacagcacag gccgttgttt cctctgctac atacggcttt 1835641 aattcagaga gcggaatcgt taatttcttc tgttcctgta tatactgctg atacttctcg 1835701 tatgcaagca ggaaattgct gatcaatttc acgtgttctt cctgcagcct gttttttttg 1835761 actgcctttt cccacttctc tgtgaaggaa cggcctgccg gctcctttgg tattccggtg 1835821 agctgcaaaa tttcagccgt taagtcatcc tctgtcttaa acactacatt cgctgttttg 1835881 tttaagttgc cattgattgg ctttgtgatc ttgttaattg tcgctgtggt tggcgttggt 1835941 gaggatggca gcactctttc gccgacaagc gcattggcaa atgatgattt ccccgagcta 1836001 aagcctccaa aaagagcgag tgtaaatttc cgttcctcaa gccttttcac cctttcacga 1836061 aacgctgaag tttgctttaa caacatgctg cattcgccta aaatgtcaga caaagtgtaa 1836121 aagcgtttga tttggtcttg aagcggcatt tcttgttcca ttttgatttc tgatttcggc 1836181 atcggctgcg ccgtcagctg gcttcggcct tgtttctgct ctggagccgc cactcttgtt 1836241 ttcttcgatt taaaccattc tgtgtctata tgcattgggc atgcggactc ttcttcccaa 1836301 atggcccaca ggcgatcggt tttctctcgg gcattattct ctaaacgtgc ctgttcttga 1836361 agaaagacaa gtttttctga ttcttggacg agccggtcgt taattgtttg cacatctttg 1836421 gaaacacgct ctttcaccat agcggagagc acctttatga tgtctgcggc ttctcttttc 1836481 gcctctttcc ggatgagctc tgccaagtct tttgtatatt gcaatacata ttcagaggaa 1836541 aaggctgcac catgcttgac cgcgtgttca atgatgctta tatcaagcgg tgtgcgatag 1836601 gcctgaatca gcttttcact ttcagcggta tagacatcaa ataccttggc gagtttatga 1836661 agcgtgtcta tcatatgcca atccgcttcg gcctctgttc gttttgccac atcagagaaa 1836721 aaagcattcc gccttttatc tctttcctgt gcagttttcg ctttagaaaa gaaaaagccg 1836781 gttttaaagg aaggctcttg tgattctaaa aatgcagccg ccaattcacg catttcaaaa 1836841 ggcgtcaggt tggcgttttt taaaatacga ttgatttctt cctgcatcct cttctctgcc 1836901 tcagtcattt gtttttcggc ctcatccaat tgatcacgca gcgattggac cagtccagta 1836961 tggatattaa gctgttcagc gaaactcgga gcgcctgttt cgtctttctt cagcatttcc 1837021 gtatgttcct ttagcagatt acggactttt tgttcggtta aagcctgcat attgcttttt 1837081 gattgctgtt ctattctgct taactcttct ctcagggccc ccatctgatt gaacgggtga 1837141 tccggttctg ttactgatgt aaaatagagc gcttcccttg aaatcccttc attgcaaagc 1837201 atctcctcta cctgcgcttg atagtctcca aatttcgtct ccgtctcatc atggcggtca 1837261 atttgattga cgataaaata cacattcgga atgctttctt ttattgatct gagaaacttt 1837321 acattttcct cagcgtgcac gtgattatag tgaacgacgt aaaacagcgc atccgcttgg 1837381 tgaagaatag aagcagccga tagaaaatgc gcatcatctg ttgaatctat ccctggagta 1837441 tcaatatacg caaccccgga atcgatctca gtatacctgt caaaaatttc gacgctttca 1837501 atctgttccc cgtctttaca atattgctgc accttgtctt tctggtaagt cccttccagc 1837561 tcagcacacg ctccgtctgt tgtatgaagc cgaactcgct tttccccgtt tctgatcaca 1837621 acaaggttag cgcttgtcgg aatcgggctt gtcggcaaaa tattctccat taacaggcag 1837681 ttcagcagtg acgatttccc cgctgaataa tgcccggtaa acgcgatata aacctcttca 1837741 tcagccgctt ttttcatgac cgcagccagt ttagcagccc tttgttcatc ttgattctca 1837801 ataaattgct tataaagttc cccggtttta tgcaaaagct cttttctgtt ttgatctgtc 1837861 ataagtctga acccctttgt gccgtttcaa ttgtgaacct ttttcgaaag atctgaattc 1837921 attccctttt cattttacac aagaataaac caaatttctt taggagaata gaaaaaagcc 1837981 gccattacgg cagcttctat aaaagaaaat ctgcaacttt tacaagttcc agattcatca 1838041 aacagattta ttagagattc cttttaatac aaaaccaatt aatacactat atgtacaaac 1838101 cgctccaagc aaaaacagca ttgtcatttg cttcaccatc ctgattgaga atctttttca 1838161 aacccatttt aacatggttg agaatgattt tcaatcgcta ttttacgctg tattcctgta 1838221 atgctttgtc ttctgcgcga attctgacgc ttaacaacac ggcattgaaa atggaaaaca 1838281 gacacatggt gacgtatgct tgataaagca gcggaatcag caaaatttcg aggataacaa 1838341 cggcatagtt tggatgtttc atccatttat atggaccttt ttttacaagc tctacacctg 1838401 gaacaacaag gattttcgta ttccaatatg ctcctaagga acaaagcgcc caataccgta 1838461 cgatctgtac gcttaaaatc actgcagcga taccgagcca ccagctggac ggctgtttat 1838521 tcatcagcag cacctcggca attaaggaca ggaaaaaaag gatatgcatc gtaatgatat 1838581 acggatagtg gctctcgcca aattcaattg ctccttgctt ctttaccttt tgttcgtttt 1838641 gcctggccac tgccatttct gctgctcttt gaacaatgag aatggcgatc aacaaccaaa 1838701 acatgagtca ggcccccttt tcccagctga ataatagcaa ctctgatgag aaacccggcc 1838761 ctaatgcgcc aatcagtcct cgttcagctt cctttttatg tccgttctgc agatggtctt 1838821 tgatcacata caagattgtg gctgaagaca tatttccgtg cttttgcaaa atgctttgcg 1838881 cagatgaaag cttttctgac gacagcccga gacttttgat gtatgcatcg atcacttttt 1838941 ttccgcctgg atgcgccaaa aaaacactga tatcatggaa tgacagctta tgtttgtcca 1839001 aaaaaatctg tacatttgtt ttgagccatt tttccaccaa ggtcggaatg tctcgtgaga 1839061 aaatgacttt gaatccttga tcggtaaagt cccagcccat gacatcttct gattgtttca 1839121 tcaaaacaga ttgggcgtcc attatcttcg gcgcaagctt cagctttgac accctgcggt 1839181 ccgccttctc tccgcataat aaagctgcgg caatgccgtc accaaaaagc gaggtgccga 1839241 tcagattgct ttttgtttta tcttccggct ggaatgtcag gctgcacagc tcggcagaaa 1839301 tgacaagcac aaaagcctca ggatacgctt tgcagtattc ggctgcacgc gcaagtccgc 1839361 tggctcctcc tgcacagcca agcccccaaa tcggaatccg cttcgtatat ggagaaaacg 1839421 gaagttcatt cataagccgc gcctcgatac tcggtgtgga aagacctgta ctggagacga 1839481 aaaaaacagc ttccactttc tcataaggaa tggcttcttg aaaaaattcc ggatgagaga 1839541 ggcactcacg aacagccgct ctgctgtgtt taagtgtttc ttctatgtat atttgatttt 1839601 tttcttcaaa gctgtgcccc tctttatacc attcaatcgg cttaacaaac tgtctcgaat 1839661 ggatttgccc gtttttaaag gaggataaca gcctgtcaat atccttaaaa gaatgctgaa 1839721 acatatagcg ggcgaactcg gccgctttct cttggtttac attatacgca ggaagacttg 1839781 ttccaatgga taaaataaac gccatgcgat cacctctttg catacattgt gccgcaacaa 1839841 tcttttttat atgcaaaaaa aactccgccg cggcggagtt agactgctgt tttttgttca 1839901 gcgaggtcag cttcttgttc tattttttta gctttagaaa aaacgttata tacaatattt 1839961 aagacgactg cagtaaagct gcccgccaca atgccattcg ttgtaagcag cgttaaggca 1840021 ctcggaagct gtttgaaaat atccggcaca acggtcacac cgagccccaa tcccactgag 1840081 caagcaacaa tcagcagatt ttcctgtttc gcaaaatcaa tgcggctgag cattttaatt 1840141 ccgtaagcaa tcaccattcc aaacatcgcc accattgcac cgcccaaaac agcggatgga 1840201 ataatagtcg tgaaagcagc gatctttgga aacagcccaa atgccattag gatcacacct 1840261 gtgaccacaa tgacggcatt ttttttgatc cctgtgagct gaacaagccc gacattttga 1840321 gagaatgccg tgtaaggaaa agcgttaaaa ataccgccca gaagcacagc cagtccttca 1840381 gctcgatagc ctttagacaa atctatctct gtcaaacggc ggtttgtcag gtcacctaaa 1840441 gcaaagtaaa caccagttga ctccacaagg ctgacaattg caacgatgga catcgtaatg 1840501 ataggcgctg cgtgaaaaga cggcgctccg aagtaaaatg gctgaatcat ttgaacaact 1840561 gccgcgtccg aaacattatc aaattgaact tttcccataa aatatgcgat gaaggtgcca 1840621 atcaaaatac cgatcaaaat cgagacggac ttgataaagc cttttgtaaa acggtataga 1840681 agcacaatga tactcaacac ggtaaaagca agtgcaagat tggagagatc tccgaaatct 1840741 gcacttcctt ctccgccggc catgttattc atggcaaccg gcatcagtgt aataccgata 1840801 atcgtaacaa cagagcctgt cacgaccggc ggaaaaaacg atacgagctt tccaaagaaa 1840861 aatgaaataa gaatgacaag aatgcctgaa gcgataatgc tgccgtaaac tgttgaaacc 1840921 ccatattcag atccaatcgc tatcatcggc gatacagctg taaaggtaca gccaagcact 1840981 accggaagcc cgatcccaaa aaatcggttg ctccacactt gcagaagtgt agccacaccg 1841041 cacataaaaa tatcaatcga tactaagtaa gtcagctgct cgacagtcag tcccattgct 1841101 tttccgacaa tcagaggaac gacaatggcg ccggcataca tggcaagaac atgctgaatc 1841161 cctaaagaca gcgttttgcc gaatccattt ctcatgaatg aacctcctgt acgaaggaca 1841221 cttttccttc ttctaaagac tgaattcttg ccaaagattc cactcggtag cccagtttta 1841281 caagttcatc tcttcccggc tgaaatgact tttcaataac aatgccgatt cccgcaatag 1841341 aagctcccgc ttgcttcaca atcgacacaa gcccgtgcgc tgcctgtcca tttgccaaaa 1841401 aatcatcgat aatcagcaca tgatcctgat ccgacaggtg ggtcccagac actgcgattt 1841461 ggctttctgt ttgcttcgta aaggaataaa cagacgctgt cagcaagttg tcggtgagtg 1841521 ttaacgattt atgctttctc gcgaagacaa ctggcacacc cagcttcaag cccgtcatta 1841581 cagcgggagc gatacctgat gattcgattg tcacaatttt ggtaataccg tcttttgcaa 1841641 acctagacgc aaattcatca ccaattctct gcataagcag cggatcaatt tggtgattca 1841701 aaaaagaatc cactttcaat acctgatcag ataatacgac gccttcttcc tctattttcc 1841761 gtttcagtgc ttccatcctg tctacctccg ttatgagaat aaaaaaagca ttgcccgctc 1841821 aaataaagag caagcaatgc tgatatcaca aaaaaccgta cacgtgcggt tccattgctc 1841881 acccatagtc ggacatttac ggtgcccggt agaaacttgc gtgccatatc cacgcgatta 1841941 tatgagtgtt cctattatat tgtaataaat tatatcaaga ttctaatctc ttgcataggc 1842001 tgaaaataaa aattcccgaa ctttaatttt gtttttttag atatcattcg tatttcaagg 1842061 ggattcgata taaaagagtc tgacgaccgc gccgccaggc ttttgattat aacagataga 1842121 gatttgaata tttgtttgat aaataatcaa ttaaatagcg aacattcagc tcttctcctg 1842181 ttgcatcttt aataatgtct aacggctttt tccgttttcc gtgaatgtgc accttttccg 1842241 tcagccattg ctttatcgga tggaactctc ctctttccaa gagagcgtca aattcaggga 1842301 gatcctcaag cattttttgt ttcagctgag ccgcatacat gtagccgagc gcataggatg 1842361 ggaagtagcc gaaatctcca cctgcccaat ggacgtcctg taaaatcccc tctgcgtcgg 1842421 tctgcggtgt aatccctaaa taatcctggt atttttgatt ccaaagcgac ggcagatctt 1842481 ccacagacac ttcattgctg aaaatcgctt tttcaatttc ataacggatg atgatatgaa 1842541 gaggatacgt caattcatcc gcttcgaccc tgataaatga aggttttgat tcattgattg 1842601 cccggacaaa atcatccagg gagatgtcct tgaactgtac aggtgatgcc tcttgaatct 1842661 tcttatagta cggagtccaa aaatgcttgt tgcggccgat aaaattctcg taaaataatg 1842721 attgcgattc atgaattccc atcgatgcgc cgtctgacaa gttcgtgcca ctgagtgctt 1842781 catcaatatt ttgctcgtaa atcgcgtgcc cgcactcatg aatggtccca aagatcgccg 1842841 tccggaaatc tttttcatca tatctcgtcg tgacccgaac gtctccccga ttcagcgtag 1842901 ttgcaaacgg atgaacggtt tcatcaagtc ttccgccatc aaaatcgtag ccaagctcct 1842961 gtaaaaaata cagactgagc tctttttgct tttctttcgg gaacgctttt gtaataaagc 1843021 ttgtatctgg tttatttccg gaagctgtca cctgtttaac aagagggata atcgcttcct 1843081 tcagctcagc aaacaactga tcaagcacct ttaccgtgac gccgggctca aacaaatcaa 1843141 gcaatgcatc ataaggatgc tcttgatatc cccaatacgt aataaaacgt ttattgaatt 1843201 caatcagctg ttctaaataa ggagaaaaca agctgaaatc agattttcct ttcgcttcct 1843261 cccacgctgt ttctgccttt gaacacagaa tcacgtattc tttgtattca gcctcaggga 1843321 ttttcttatt ctcttcatac tcttttttcg ccagttccac tgcttttttc gtatcttccg 1843381 acaagtcatc aaatcgttca tacaggacat cgataagctc cttcattcga tctgatgttt 1843441 ggatattgaa tatatctgtt gaaagctggc cgatactttc ggcacgatcc tctgagccat 1843501 ttttcggcgc gcctgttctg gagtcccagt gcattaacgc aactgcttcg ctgtaatgtg 1843561 agattctttt taaaagatca aaaaattctt tttcatatgt atgtatctcc atatccattc 1843621 cctccctatt ctagccgttc cattacaggc taatggaagg gggtatgaaa gtcaaattgt 1843681 ttgtataaaa ggctgccggt atgttttgtg gcagcctttt tattcagttg atcgtcattt 1843741 gattttttgg cggaggtgtt ctccgctttt tctgcttgat ttttttatct acccacactg 1843801 ttgccagcgg ggttaagagc gaggtgacaa taacgcttgt cgcgataatt gcagttgccg 1843861 actcagcaac tggcgcaaat gaggcattcg cttccgctaa tgcatatggc acggctacag 1843921 ccgcccctgc cgtagaagaa gcggccactc ccgcgacacc atctccccgc gcaataaaac 1843981 gatcaagcaa aaacaaagaa ctgcccgata aaatgacgac agaaactccg ataaaaatgc 1844041 cgagcagccc tgattggatc agcattccaa aattcaaggt attgccgagc gaaaaggcga 1844101 aaaatggaat gatcgccggc acaaccttgc tgaataagtc tctgagatca tgatccagat 1844161 ttccaagtat acatccaagt aaaaacggga tgactgtcgc tgccagcgtt tcccatggga 1844221 atgcggcaag tcccgtcaca ccaaacgtca ccatggtcat aaaaggacca gattctgtac 1844281 tgataaaggc gaaagcgccc gcatcctctt ttcttcccat gtgattcatg agcgccaaat 1844341 acagtccgcc gttcgtttca ttcattaccg cgacaattgc taaaacagaa aggcctgcaa 1844401 aaaagccgga ttgtatgcca tcgtcaggta taaattgcgc tgcgatcacg ccgagcagcg 1844461 ccgcaaatcc gatcttcccc aataataacg tgattccttt tcttgcgata tagcctgaag 1844521 aacgaaaatc aatcgttgct cctacgcaaa agataaaaac acccagtatc ggcagcgttc 1844581 cggtaatcaa agcacccgta aaccctccaa agaactccgc tgttccaggc gcaaacgtgt 1844641 tgagcgccgc tccaagaaat agcggaataa tcatcattcc gccaggtacc cgttcaattg 1844701 tcgccttgat tttcatattg tggattctcc catcctccgg ttatgaaaaa acaattccac 1844761 ttacacttgg aaaacagcct gcaaatcctc ttttgaacag ctgcccaact ggctgccgac 1844821 tccgacggcg ccagctccgg ctctaagcca atcaggcact tcagacggat gtatcccgcc 1844881 tgtcggaata aaggtcacct gcgggaaagg acccgctaaa tttttcataa acggaatgcc 1844941 aaacacaccg cttgggaaca gctttaatgt cgtaaaaccg aatgtcagcg cttccataat 1845001 ttcgctcgga gtcaagacgc cggggatata atgtgtcttt acaaaagata gatgttcagc 1845061 aagatcagct gaaaaacccg gactgacaat aaactgcgcg ccagccttag cagcttcccc 1845121 agcttgctgc gcgctgatga ccgtacccgc gccaattaaa atatcttccc tattacggaa 1845181 ggattcgata atatctgatg ccccgggggt cgtatacgtc acttcaactg cacgaatccc 1845241 tttatctaat aaactctcaa tctgctgaca ggcctcctgc ttatcctttg aacgaatgac 1845301 tgcaatcagc tttgcttctt tcagacggtt ttcaacgact ttggactcca tattaataat 1845361 cccctttctt ttggtgaacc gttctttgag cagataaaaa agaagctaat ttctccctgg 1845421 tcggcaaacc gtccatatcc cccggtgcct gcacttgcaa agcgccaatc gcatttcccc 1845481 tttgcaccgc atccttgtac gacaaaccgt ctaggatacc gctgattaca ccgactgcaa 1845541 atccgtctcc ggcgccgacc gtatcaacca cccggtcgac ccggcagcct tctagaaatc 1845601 cttcacttgt ccccgtttta aagtaagcgc cttcttttcc aagtttaata gcaacaaagc 1845661 tggcaccttt tttcaaataa tagtcggcaa tgccttcagg tgttttttct ccggtcaata 1845721 gctctccctc tgcgataccc gggaaaaacc agtctgcaag cccagccaga tcattgattg 1845781 tgtgtaccat tgttgcttga tcaggccaaa gcgaaggtct tacattaggg tcgaatgaaa 1845841 tggtcttccc tgcgtttctc atgtcgttca tgacatgata cgtgaagtct ttcatctcgg 1845901 ctgataaagc aggcggaata cctgtcacat gcaaatggcc tgcgcattga aaataatctc 1845961 tcggatattc agctgtagtt aatgtgcttg cagctgagtt tttcctatag taggtaactt 1846021 gcgggtcgcc ttctttcact tttgacttca gcagcagccc ggtgggattt tcgtcctgcg 1846081 agcggatcac gcgggacaca tccactccct cttttttaag ctcttgtaaa ataaacgttc 1846141 cgagctgatc attgccgacc ttgctcatcc atcccattcg aaatccgagt ctggcaaggc 1846201 cgcaggcgac attgctttct gctccggcaa gccctttaga aaaagtggat acttcatgaa 1846261 ggcctccata ctcatttgca taaaacatgg ccattgattc cccgaatgtc accgcatcaa 1846321 gcttcatctc ttcccaacct cctcttagtt gagggcacct aggattaaag tgactttctc 1846381 atgatgactt ttgcctctaa ttcaatggtt tgaggcgctc ctttgtcacc ttcaatcctt 1846441 tttaatacac gttccatcgc cgtcctgccc atatcatgtg acggctgggc gatcgttgta 1846501 atgcctggac cgatcagttt gtaccactcc gtatcatcga atcctgcaat ccctatatct 1846561 tgagggatgc gcaggccaag ctcttccata cagctgatga ttttcagcat aatcaagcca 1846621 ttcaaagcca gaatcgcttt tttttgctcc ggcatttcct tgtgaaaaga acgaagctcc 1846681 gccttaagct gctccttgtc ctttacgtca atttcatgca atctgacaag cccgttcaca 1846741 ttttgaaccg aagccatttc ctgatacaca gctgctcttt ctgcacgagg gctgatagag 1846801 gaaatcggtt cggtaaacag cgcgacatca gtataccctt tgctgtacac cttctgaaga 1846861 atctcttttg tgatccatct gttgtcagtc gttacggtat ccagtttcag atccggcagt 1846921 ttccggtcaa ttaagattgt tggaatttgc tgttcagcaa aagcgcggag tacatccttg 1846981 ttttcccctg ttgcgtttaa aatcaagccc tcaaccgaat gggcttctag ctttaagagc 1847041 atttcccgct ctttttcagg actgttatct gtgttgcaca ccataatgct gtatccatat 1847101 tgatcacaaa cctcttcgac tcccctgaaa gcagcgaccg aaaaaggatt tgtaatgtca 1847161 gccacaacaa atccgattaa cttgcttttt tttattttca aaccttgtgc cattttactc 1847221 ggccgataat tcaattctgc gattgccttt ttaatgtttt tcactttttc aggagaaatc 1847281 gcgtcaattt ttccgttaat atagcgggaa actgtcgatt tcgaaactcc tgcacattca 1847341 gctacgtctt tgatggttgt atggcctgtt gttttctttt tcattcaagt gctcctgtat 1847401 ctcatatatt tgaaaccgat ttcaaaaccg ttacaacaaa agaataccat aattttaaaa 1847461 tttgggaaga gtttttttaa taatatgtca attcattatt ttttcgttga ctcttttcac 1847521 tatttatcct aaaattttct ttgaaaccgt taccaaaata ttttcattca agtgatgctg 1847581 aaatcctaac caagggggaa atataatgga aaatcgttat tctgtacatc ctgaacaagt 1847641 aaaacgcttt acaacagagg agcttcgcag tcatttctta atggattctt tatttacaga 1847701 aaacaaactt acgatgtatt actcacatga agaccgggtt gtcatcggcg gagcggctcc 1847761 agggcaaagt gaactgaagc ttgatgcagg tgattttcta aaaacagact tctttttgga 1847821 acggcgtgaa atcgggatta ttaatgtcgg ccagcctggt gccgttagag tcggcgatga 1847881 tgaatatgtg cttcaaacaa aggattttct ctatattgga atgggcaatc aggatgtatc 1847941 gttttcaagc ctgaacgggg aaaaagcgaa gttttacttc gtctccgctt gcgcccacaa 1848001 aagctatccg acacaaaaag ccgccctatc tgaactgaca ccggaccgcc ttggtgatga 1848061 tgcagcgtct aatgtcagaa gtctgtacaa agtcattcat caggatggca ttaaaagctg 1848121 tcagctgatg atgggaataa cgatgttaga tcaaaacaac aactggaata ccatgccagc 1848181 acacgttcat gaccgtcgga tggaggctta tctttatctg gatcttgaaa aggactcaaa 1848241 ggtatttcat ttcatgggcc agccggacga aacacgccat cttgttgttg gaaatgagca 1848301 ggctgtcctt tctcccgctt ggtctattca ttctggcgca ggaacatcaa actatagctt 1848361 tgtgtgggcg atggctggag aaaattacac atttacggac atggatctca ttccaatgga 1848421 tgggctgaaa taagatgggt tatctacatg acgccttttc attaaaagga aaaacagcgc 1848481 tggtgacagg cccgggaaca gggatcggtc aaggaatagc caaagcccta gccggggctg 1848541 gcgctgatat tatcggcaca tcacatacaa gcagtctgtc tgaaacacag cagcttgtgg 1848601 aacaggaagg ccggatattt acatctttta cattggacat gagcaagccg gaagcgataa 1848661 aggattctgc agctgagctg tttgaaaaca ggcagatcga catccttgtc aataatgccg 1848721 gcattattca tcgggaaaaa gcggaagatt ttccagaaga gaactggcag cacgtactga 1848781 atgtcaatct aaacagcctg tttattctga cacagcttgc tggcaggcac atgctgaaaa 1848841 gaggtcatgg aaagattatt aatattgcct ctctcctgtc ttttcaaggc ggcatcctcg 1848901 ttccggctta caccgcgagc aaacacgctg ttgccggttt gacaaaatca tttgcaaatg 1848961 agtgggcagc gtcaggtatt caggtcaacg caatcgcccc aggctatatt tctactgcga 1849021 atacaaagcc tattcgggat gacgaaaagc gaaatgagga cattttaaag agaattcctg 1849081 ccggccgctg gggccaagcg gatgatatcg gggggactgc agtctttttg gcatcacgtg 1849141 cttcagatta tgtaaatgga catattttag cagttgatgg cggctggcta tcccgctgac 1849201 aaataaaaaa gctgacgaac gatcgtcagc ttttttccat tacatcatgt gcggttcaac 1849261 aggcaagacc tttttgacct catcaatgat gcgttcattt tctccgccag cgtaaatgtg 1849321 aatcgagccg ctgtcttgat tcgagcgaat caggcgcccg atgccctgcc gtacacgtaa 1849381 caacatatat ggcagatcaa cttcttcgaa cggatctttt ttcgctccgt tgcgcttcgc 1849441 tgtaaataca ggatcgtgtg gcgggaacgg taatgaccaa atggtaacat tcttcaatgc 1849501 gtcaccggga atgtcgagtc cttcccataa gtgaactgaa caaagtactg tttcttcttc 1849561 ctcttggaat ttctctacta agctgctgat ttcctcatca ccttcgaaga aaattggata 1849621 cggcagctcc catgccgccg acagctcttt aaactcgttt aattcttcaa aagaagggaa 1849681 aagcaccagc gttcttcctt tgtatcgttt gattgtttca atcgtttcag ccgttttttg 1849741 ttcagcgtcc atatctgttt ttgcgtatag attaatactc atttgctcgt cataatcata 1849801 aggggaatca acagttaatg acaaataatc atgaatccca agactgtcgg caatataatc 1849861 aaacgaaccg ccttctgaca gcgtagcaga agaaaagata taaggaattt tcttagaaaa 1849921 cactttttcg ccaagtactt ctgctaccgt tctcggcatc acgacaaagg ttgattctgc 1849981 ttcctttttc tccagccagc tgatcgcatc cttttgatat agagataatg aatacgccat 1850041 ttgttcaaca tattcttcca ctactgacag ttcgtattga tcaatcgtat acatttcaga 1850101 ctcaaataca agtgcctcac cgattttatc aagtaaacgg caaagctcgt ccgccgcctt 1850161 tttgacacga tggtcatttt ttatttctaa acggtgtgaa ccggctactt cctttgattc 1850221 ttcagaaaga acatagaaaa attcgtcgtt tgcgagaagc gcatcttcaa tcaattctgc 1850281 aaactcttct ctgatgtcat tttgcagcaa tcgttctaaa aacaattcaa gagtagactg 1850341 cttcactcta taggttagcg ctttttgcgc agcaaactct aacaagtgcc cctcatcaaa 1850401 tacaactgca ctatgatcag gcaagagcgg cagctggccc tctcgtttgc gtgattcttc 1850461 cgtccacaca tgctccatat aaaaatcatg ggaacaaatg attaagtccg ttgacttgcg 1850521 gtagtaatct ctggaaagtg tcagaccgca tctgtgtctc atatcacaag tcagacagtc 1850581 ctgaaacgag tcgtagctta cgtcagacca ctcttcattc gatagatttg cgtactgctt 1850641 acggtcgcca tacggataaa agcgctgcat cgcctgggac tcgtggacaa atgacggtaa 1850701 cgactcataa agatccagcc atttatcatc atcagaacgc tgcattgttt tttcaagctt 1850761 cttcaagcat aaatattgct catgtgattt tgacagcctt gtatcaattt tcagatcaag 1850821 atgctcagcc agcttagaaa tatcgccctc ttttttcacc agctgttcaa ttaatgtttc 1850881 atccgcacaa gcgatgatgg caggtttgcc gacatacctt gcatagctga ttgcaaaaag 1850941 aagatatacc agcgttttcc ccgttcccac tccagcttcg gcgaacatga cttttttctc 1851001 tttaaacgcc cgctccagct gaaaagccat aaatacttgc tcgtcccgaa gatcaaaccc 1851061 tttttcggga aggatatcgt aaaacacgtc accaatccaa ttgttcaatt cttcataaaa 1851121 attctttgtt ttcgttaaag aaaaaggcaa acgtgatgtt gtcacctagt tccaaccccc 1851181 aactattcga cattcagacc accaataata tcattttccg ctgatgaata caataaaaaa 1851241 cttggcaatg ccaagttttt tgcagtttac ttacgattga tcacatgcga cgataaaaaa 1851301 ggatggtctg ttgaataaat atgttctacc gctttttcta aatcagtttg cgcatgcgaa 1851361 atcacagacg gagacgaatc agtcccgagc tccttcagct cgtttgctgt tgcgtcaagc 1851421 gccctttgaa taagattaaa atgttcgctg ttcagcatga gatcacctct gatggaaata 1851481 atcatcattg tatgcgaact tttcatttta tatacatgct ttaccgcatg ttatcaccga 1851541 aacatgcaca aactacactt gatattccgt ctccggatta tccgtcttat caacaatatt 1851601 ctatcaggga gtgatgttga catgagttat agaaaccgat tagatcagca ttctgaactg 1851661 tttcatcaca attggacgcg gcctaaacgt tcaaagtctc aagtaaacgg tcacactgaa 1851721 atgtcccaaa ccaacattat attgagaagc aacgcgaaag ctcaccgttg gtaacgatag 1851781 aatagggctg aaagatgaaa gaagacgcat gcagagcgtc ttctttttat gcgttttctg 1851841 ttttcttgcg ctgcggtctt acttttgacc agtattgata ataatccgtt ttaataaacc 1851901 cgttaaagag ttttcgtttc ttcgttgctt ttctgccata tgcttcctca aagttttcat 1851961 ttgatgtcag catatacaca gaccaagtat caagcggctc gaacgcctgc cccatttctt 1852021 tgtacatctg ctcaacggct tttttctcgc cgagacgctc tccatatggc gggttgccga 1852081 caattacgcc aaattccaga tttgtggtaa agtctttgac ctgcatctgt ttgaactgga 1852141 ttagatctcc caatcctgct tcctctgcat tttcttttgc gatttgaacc atgcggtggt 1852201 ctatgtcgct agcgaaaatt gtaagcggct gatcataatt tgccttttct tcgacttcaa 1852261 gccgcgcttt gttccacaga tctttaccga tccattccca atcctctgat acaaaatcgc 1852321 ggttgaatcc cggggcgatg ttttggccga ttagcgccgc ttctatcgcg attgttccgg 1852381 agccgcagaa aggatcaaca aacgggcggt caggcgtcca attggttaat tgcaccaaag 1852441 cggcagcaag tgtttcttta atcggcgcac cgccctgatc gacacggtat cctcgtttgt 1852501 gaaggcccgt ccctgatgag tccagtgtaa tcaaagcctg atctttcaat aaagatattt 1852561 ccactttata ctcagcacct gtttcttcaa tccaatcatt ggctttgccg gactgcagct 1852621 tgagcttttc gacaattgct tttttgacga tccgctgaca gtcaggaacg cttgcaagtg 1852681 ttgattttac cgattttccg atgacaggga atttcccgtt ttcaggtata aatgagcgcc 1852741 agttaatcgc tttcgttttt tcaaacagtt catcaaatgt tttcgcttta aaagaagcaa 1852801 cctgaacctt tatgcggtcg gctgttctaa gccaaaggtt cgcacggcag atggcaagtg 1852861 catcaccttc aaaaataact ttcccgttat caaccttgca ttcgtatcct aaatctcgta 1852921 cttcctttgc gacaacagct tcaatgccca tcggcgccgt tgcaattagt gtatacttct 1852981 tcatcgtatc accctgtctt ttaaaacttt tctcttttca agataaaagc tctccttata 1853041 cgggagagct tgttttcatc attttaaatg taagtggtct aacgttctgt aagccatgtt 1853101 ttgttccatc gtactgcaaa cggctcatca cctcgtactc aggcggcaat catctatcta 1853161 cagaaagcat tctgtccttc tctccgttga attccgttaa gaaggttccc ctaccaaaat 1853221 ttgggtttct cgctcgaggg gtttaccgcg ttccactctc accatttcta gtgagacttc 1853281 gtcactgtgg cactttcaag gatactcagc catatccgaa gacgtaggct tttttcctgc 1853341 cgtcagcctc taaagactgc cctagcttat gacttcgcta ggcacgaaca ctacgggcat 1853401 ctcagcaccg tgcgagcatg gactttcctc tacagattca agatctgcag cgattacccg 1853461 aacgttaaga acatgaatta ttatataaca actgattaca atttacaagc gccatttttt 1853521 tcaagcgtga tcaatcataa agcttgctgc caaaaacgtg tttttctaag ttagacagcc 1853581 gttttaaaat atcaaagttt gttgtgttag attgcacagg ctgttttttg ctggcttctt 1853641 caagctgttt tttcagctgc agattttcct gctgcagttc ttcaatttct tgatggaagg 1853701 tttcataatc cttaataatc atatctaaaa atttgtcaac gtcttcttgc ttgtagcctc 1853761 taacgcctgt tttaaattct ttttccaaaa tttctttcgc agaaagcttt actttatcag 1853821 caagcatctt tttcacctcg tatcgtgaat catcacatat attttttcag aaatctgtac 1853881 ggttgtcaaa tttctctctc attgttagta gctgtcttcc tccactgtca ctctcaagtc 1853941 atccattgta ataaagtaga tgggatagcc atcctgttcg cgcctttttt ccgctgtccc 1854001 aagcatatac ttaggggagc cttccttttc cgggtcatat aaaagcagaa gcccgtcgga 1854061 cttatcaatg aagaactgat ttttttgttt gaattgaagc gggctttcat aaggacggtg 1854121 agtcaggctt gcttcatagt ctgcctgagc cagaactgct tcatactgtt ctttattcgg 1854181 ttctttccag ttcttttcct gctcgtaaaa tggtgtgatg acagctacct ttaagtcagg 1854241 gtattcctcc tgcaaatcat atgcagcttc tgccgcccac agctcaactc caagctggcc 1854301 cgaaattaaa atccattcta atccttcatc caaaaaagca atcagccggt ttttaatggc 1854361 tttttttatg taatacagcg ccttgtcatc ctgcttaaat atccccagtt caaacggttt 1854421 atagcccgtt attgccaata ctttcatcat ttcacctgct ttaaaaaatg gggctcccgt 1854481 gggccccatt tgttgtgctg cattgtttac accatcaagc tgcacgtttt ccatactagt 1854541 agtcgcagca aggttttcct gcttgaaaat gctgatgcgt agccgggtca acatttgaga 1854601 aagtgtgtgg aaagtagtga acgtgctgaa aatgctggtg gtttacgttt gttgtatgct 1854661 gtgggtgaat gtgcggcacg atagtcttcg aaaacgtatg gtgttcacag caatgagtag 1854721 gatggacaat tggcgccatc atatgcggtc tgcagtgatg catgataaaa tcccctttcc 1854781 ataaacttta ttacaatact aagttatgaa aaataagggg tacatgttct gatgcaaaga 1854841 cctattttaa aagtgtgcaa ttaagctgtc tttaaagttt gaaaacacaa aagcaatcaa 1854901 aaataccaca acaaagaaca agtaaaaaac acccttatac ataccaactc tccctttaaa 1854961 aataactaac gtcattttac aggattcgcc gctattctac aacaaaatca atgtgaattc 1855021 agcaaaaaaa attcatggcg aaacaagtcg tcttttgcgc tttcccgggg aatatttaag 1855081 aggaatattt cctctttagc cgggcaattc tcacatgcag tttttcagtt tctttctctg 1855141 ataagcatgc cgcatcgcta agcgattgct ctgctacttg caatgctttt ccgaattctt 1855201 ttttcttatg ctcaaaatat ttcgcgagct ctattacagc agcgtatctg cacttctggt 1855261 tttgcgagcg ggacagcttt tcccaaagcg gcactgcttc ttccaagcgg ttttgttttt 1855321 tgtacaggag cgataaatcc agccgtgcac tgtcctggtc ctcaaacgat ttttctataa 1855381 gcctttccaa ctgcttgatc gcttggtccg tttctttatg agccataaac catttcgcca 1855441 tagcataggc ttcactgtgt tcttttggcg catgtgattc tgaaaggatt tttttagaca 1855501 tatggatgta caatgaaatg agtgataaca catccatttc attatgatgc aggacacctt 1855561 ttaaaagatc cggctcttgc gccttgataa aatgaaagta aagcattggc gccaagtagc 1855621 ccggtgtgtc ttctagcctg cggatgccga gctcctcttt ttcaaccgtg ccaagagata 1855681 cacggtccat tttgtgtttc cacaggcgtc tagctccatg caaaagatca aagtggccaa 1855741 actccggaag cttcggaagt ctgtcacgga tcaaggtgtg ccttgttttc acctgcggcc 1855801 aatcaaaggc tttgccgttg taggtcacaa gtgatgtaat gtcaacctcg cttaaaaagc 1855861 tttggtacaa ggcgacttcg ttccccggtt tgggcaaaag atgctgtttg actgtcactc 1855921 ggtcttcata tactctcgca tgcccaagca aaaaaatggt attcccagct ccacccccaa 1855981 gaccggttgt ttctgtatca aagaaaaaga ggttgttttt gttataccct tttgctgaca 1856041 atgtatgcga caggccgctt tgattccaca gtgtgatcac ttcctcaagc tcagaaaagc 1856101 tgtataaccc atggcggtga gaaagcggat attctacttc tctgatgagg caatattcat 1856161 cttcgaagat gaaaggcttc atgccaaaag cctcccactc ttctaaaaac gggatgtcat 1856221 caaagtggtt ttcttgtttg cctgcttcta ttttttgttc tccttcgtcg agcgccatgt 1856281 gctttttcat ccgttggagt ttccctttta atgacatatc cggcctccct ccttacgaca 1856341 tttgatccaa cagctgcaaa attctttcct ttgcttttat cccttctatt tccgtaccta 1856401 tacaagacgg acagccgtca tgacaaggac aatgtgtaat cagttgtttc gccgcttcat 1856461 taatgtctga aaaacgttta aagacttcct ccgccaaacc gataccgccc ggataatgat 1856521 catataaaaa tatggttggc aatccggtat gggctgcttt aatttgagaa acaacatgaa 1856581 catcatttcg atcacacatg atatacacag ggacaatatg ctgcagcaca ttcgagatgc 1856641 caagaagcag ctgttccagt gtcttttccc cgatgtcttc atccgctgtt ttgatttcga 1856701 gccaagctgc acttgtatgc agttcttctt ccggcaaatg aataggtcca gacccaatat 1856761 tttcaaaagt ggtcattttt atttttttaa aaatggtcgg cagggcattg acagtgacgt 1856821 ctccgtagtg caatgacgta cggctttttt ctttcgtttt atcgatttct aataccttca 1856881 gctgaactgc caggtttgca tccgtataat attcgacatc gacttttctg acatacgcct 1856941 ttttatggtc ccaatcgagc ttctcaactt gatactgaac gccttcatgc aaataaatcg 1857001 cttcatcatg caaaagcgtc atcgcactaa aacggtccat ttcaccgata atccttacat 1857061 ttgcaatatc cgactgatca actataacga cattttcctg ggaggcggaa cgcaaactga 1857121 tgtttgacgc agggaacgac tcacttgccc aatggtaccg ttcgccgttg cggtgaagaa 1857181 cagcctcttc ctgaagatac tcaagaatat cactgacttc catggctcca aattcttcat 1857241 cagctctaaa aggaagctca taagccgcac actttaagtg gtctactaaa ataatcaaat 1857301 tctccggatt gattcttgca gattccggcg aacgattaaa gaaatattca ggatgccgca 1857361 caatatattg gtcaatcggt gttgaattgg ctaccatgat aatcaaagat tcaccgtgtc 1857421 ttctgccggc tcgtcccgcc tgctgccaag cacttgcaac acttccggga taccccgtca 1857481 ttacacacac ttgcagctgg ccgatatcaa caccaagctc taaggcattc gtactgacca 1857541 ctcctaaaat gtcgccttct ctcagtcctc tttcgatttc tcttcgctct ttcggcagat 1857601 agcctccccg atagcctctg attgattttg ttccaatctc ttttttcaca agctcctgaa 1857661 tatggcttaa aataatttcc acccgaactc tgcttctggc aaaaacaatg gtctgcactt 1857721 tgtttttaag gaactctttc gccagttcat tcacttctgc ggttgcgctc cttctaatat 1857781 tcagcggttt gttcacaatt ggcggattgt aaaacacaaa atgcttgcgt ccgctcggtg 1857841 cgccgttgtc atcgaccagc cgcatcggtt tgcctgtcag ctgctctccc aattcctttg 1857901 ggttggcaat cgttgcggaa gtacaaataa aaactggatc acttccataa aaccggcaga 1857961 tccgcttcag ccgccggatc acatttgcca catggctgcc gaacacacct cgatacgtat 1858021 gaagctcatc gatgacgata tacttaaggt tttcaaacaa actgacccat ttcgtatgat 1858081 gcggtagaat ggcagaatgc agcatatcgg ggtttgtaat gacaatatga cctgcttttc 1858141 tcaccttttg tctgattgcc ggagacgtat ccccgtcata tgtaaagctt ttaatatcaa 1858201 tgcccatttc atcaataatt tcatttagct cgctcttttg gtcttgtgcc agcgctttag 1858261 tcggaaataa atataacgcc cggtttgttt catcttgggc gatggactgc aggactggga 1858321 ggttgtagca taacgttttt cctgatgctg ttggcgttac ggtaacgatg ctctctcctt 1858381 tttgcacata ttgaaaagcg gaatattggt gagtatatag ttcatcaatg ccccttttcg 1858441 aaagggccgc tttgattctc tcgtctatac tttcgggcat aggccttgtt tttgcttccc 1858501 gaggctcaat ttcatgccaa ttcacaacgt tttcatttcc ttttaaatca gaaatgagtt 1858561 cagtcagtga tttctttttc attctttaca cctctttgtc aagtacagtt taccgaatat 1858621 ttgtttgcat ggctaggtgc aaattttata cagttgaata aaaaaagcaa ggcatacgcc 1858681 ctgcttattt cgcttttatt gtaaagagct ttgattcgcc tttacgagca gccttttcgc 1858741 ctgccgatac cattgatcct acagcctcac cattcattat aacgattggg atgactgtgc 1858801 tgctcgcttt ttcttttatt aattccaaat cacatgtaat cagcgggtca ccgaccttca 1858861 ctttatcccc ttctttaatg tgggcagtaa atccttctcc gttcatattg actgtctcca 1858921 gcccgacatg aattaacagc tcaattcccg agcgagtccg aatgccaacg gcgtgtttgg 1858981 tgtggaaaat ctgaatgact tcaccttcag cgggagaaac gatttcaccg ctagaaggtt 1859041 ccaccgctat tccttctccc atcattttct gtgaaaaaac agggtccggt acatctgaca 1859101 ggtccattac tgtaccgtct gccggagaat aaataacctc ttctgtcacc ttttcctgaa 1859161 ttttgcccat tccgaataat tttttcagca atgtattttc tcccttctca ttcacttcaa 1859221 ccgttatccc ttcattcacc actatttaac cacactttca attttgcttc aatttataac 1859281 aacatctggc atagacgcat aatctggtta aaaaaggcgg tggcgatatt ggaattccat 1859341 gatgacaaaa agaacgaact gcaaaagaaa gaagaaatca taacggaggc aatcgacact 1859401 ctttttcaat cctcagcgtt cggcaacctt ataaacggat ttcagaacct aatcaactcg 1859461 agtttaaagg atgtgcagac gaccatacat gtcagagaaa gagatactgg gctgtatatc 1859521 gatattacca ttccggcgac gtttcgagat ggcgagatcg tcgttgatgt taaatcgagg 1859581 tatctccatg taacactcca agaaaaacag aaacaccaaa atgaggctac ctttacaagc 1859641 atgacaagaa cggttcagct gccttatgaa gttcgccaag aagatatgga aacgtcttgg 1859701 aacgagcaga caatgacact tttctttcca aaaaataagc atgaatgaac gattcattca 1859761 tgcttctatc atttaaaaaa gctggtaaat ccctttatta aagatccgac ctgattcatt 1859821 gcactcatta cttgacctgt cgtatccatc attttattaa aatcaaattg cccattggct 1859881 tttttgaact gcgacataat gctttgaaat tgtgaaggct gctgttgatt aggccttggg 1859941 ataggataag ggttagaaaa tacaggcggc tgcataggca taggctggat cggagcataa 1860001 ggctgataat aatcctgctg tccataatgc tgctgaggca gttgttgctc taaataaccg 1860061 ggtgcagcct gctgataata tccttgcata tgctgaggat aataatagcc catttgccga 1860121 ggatagcttc gagagctccc gttcattgcg attcccccct aaacacaaca tatttctctt 1860181 ctatatatgt atgaatgact tctattgttt gtgtcacaag tgatgattag catttgtcaa 1860241 attgtgtcga aagtttaaat tttttaaaaa cagaaaaaag tcgaatcatt atggtaccat 1860301 attttcaata cagatgagag gggatgcacc ataatgaacg tatcatactt aagcaaacgt 1860361 tttgcagaaa tgaagaaata tgaaacagac tgtatgaata aactgatgga ctttgccaag 1860421 ttcctctata ttcaaggaca tctcagcata actgagtttc gtaacagtat gaaggttctc 1860481 gaagcaaatg gagcagaaag cccggcatat gagatgaatt aacgtccggc cccctataaa 1860541 aacgaaaaga agacagcctt ttaccggctg tcttctcttg caatttcatc ctttactgcg 1860601 tgcaatgtat aaaggactga ctcagtgatg tccttgaatc gttttttatg aatatgatga 1860661 acataagatt gaaggaccaa ttccaggaaa ttatccttta cggcctcaat ttgctcttta 1860721 tgcacatatt ttggccggcg gacttttatc aattcaagag caccctctgc ccagcgagca 1860781 gccagttcat cattctcttc aactgcaggc tttatcgtct caaaaaaatc ataagaatga 1860841 ttactgtttt ttccttcctg ataccgatca gcgccttttt cagcaacttc aatcatttgc 1860901 tcggtcattt ccagcaaagt ttgtgatagc aatatctttc acctcaatgc ctatcgtacc 1860961 aaatttcact cacaaattca gccgatgcgg tataccttct caaacgcata cctgtgttca 1861021 ggcgattgat acagctcatt tatacaaata tgaagatcta tgatttcttc ttcgagcaca 1861081 cttaggcgat cgttctccgt ttcccgcatc tcagcctcta atgcatttac agaatgattc 1861141 aggctttgct cagctcgcgt taattcatct tctatatcag aaagcatacg gagaatatct 1861201 gtcttgcata cataaccgga cattcgtgta cctccctttc cttgtctctc ccggttaaca 1861261 ttctttgctc tcaaggctct ttccttcctc atgacaaaac tagaagcaaa tcgccaaaca 1861321 aacaggtatt ccacgaaaag ctgaagtttt cgacaaaaac acccgcaaaa attgtatgat 1861381 cctcctcatt aatgcaaacg atacttgtga ggaggtgccg tatgaaaaca agaccgaaaa 1861441 aagccggcca gcaaaaaaag actgaatcaa aggcaatcga ttctttagat aaaaaattag 1861501 gcggcccgaa ccgcccttct acgtaagaag caaggaattt ccttgcttct ttattttttc 1861561 agccactgct ccaccgcaaa aagcgcatga agctggcgct ttttatgtaa ataccagtct 1861621 gtcaattcaa tctgcttcgg caattcctcg cgcctaaaga acgttttctt tatctttcca 1861681 tgaaaccaat ctgttttcgt tccgtctaat gagtggatta actcagggta gcatgtcctt 1861741 agcataggag atgttctttt tgtaatcccg atcatctttt ccatatcaaa acgggaacct 1861801 gtgtgcggca ctgtgtgcaa aaagtgataa aaagaggaga acaattctgg cttgaacagc 1861861 aattgagaca gctgctttcc cagccttatc ctttcctccg cctttgaaaa gcgtttcact 1861921 gaaatgccgt aaaaaaaccc atttgaggaa ggaaaaataa cggtgttaaa atgaaaccag 1861981 tcacttaaat aaaaaggaat cgtgtcaaaa acattctttt taaacgaagg attttgtata 1862041 ataggtgttt ggatagtgtt ttgttcattt ataatgaggg catacattag ccgctccgta 1862101 tttcgctcat gccaaaaacg ggtccattct tccgacataa attgtgagac gccaaacaca 1862161 tgcagcagat gaaacagcgg tttcccaact ctttttgacc agtggtataa aagaagctgc 1862221 ggataggcat ccgaaaaaat aagccagttc gctctttcat aggctaaaaa gaaccatttt 1862281 tgctgtctct cacggagtcc aagctgaaac agactgcctt ttaagtcagt cattgaccag 1862341 ccggcattac gagaaacgaa agaagccaaa agcgaccatt tgatttccgg atgacggtcg 1862401 taaaatgctt tataagcatt tgttcttgaa atgttatccg cgtttttcat ttttgtctgc 1862461 cgctcaatcc ggctcagaag ctttctgatg gcctgttgtt cttgcacgtt cattcacttc 1862521 cgtcatgatt agtttaataa ggaggatgag aaagtgattc ggtatcctaa tggaaaaaca 1862581 tttcagccga aacattcggt ttcatcccaa aacagtcaga aaagggcccc gtcttacagt 1862641 aatcgcggaa tgaccctcga agatgactta aacgaaacga ataagtatta tctgacaaac 1862701 caaattgccg ttatacacaa aaagccgaca cctgttcaaa ttgtaaatgt ccattatcca 1862761 aaaagaagtg ccgcagtgat taaagaagct tactttaaac aatcatcgac aacagactac 1862821 aatgggattt acaaagggcg gtatattgat tttgaggcga aagaaacgaa aaacaagacc 1862881 tctttccccc tgcagaattt tcatgaccat caaatcgagc atatgaagca ggtaaaggct 1862941 caagacggta tttgttttgt tattatatcc gctttcgacc aggtttattt tttggaagcc 1863001 gataagctgt tttatttctg ggacagaaaa gaaaaaaacg gcagaaaatc aattcgaaaa 1863061 gatgagttgg aagaaacagc ttatccgatt tctcttggat acgcacccag aattgattat 1863121 attagtatta ttgaacagct ttatttttcg ccatcatctg gtgcgaaagg ttgattaacg 1863181 aaaggttgag atgttatgtc agatcaattt aacagccgtg aagctcgacg aaaagcgaac 1863241 agcaaatcga gtccttcacc gaaaaaaggc aagaaacgaa aaaagggcgg attgtttaaa 1863301 aagacccttt tcactttact cattctgttt gttttaggcg tagtcggcgg tgctgttaca 1863361 tttgccgtca tggtttctga tgcgccgtcc cttgatgaaa gcaaattgaa gacgccttat 1863421 tcatcaacga tttatgataa aaatggaaaa gagatcgccg aagtcggcgc cgaaaaacgg 1863481 acctacgtct cgatagatga aattcccgat gttgtaaaag aagcctttat cgcgacagaa 1863541 gacgctcgtt tttatgagca ccacgggatt gaccctgtcc gtatcggcgg tgcattagtt 1863601 gccaacttta aagacggctt cggggctgaa ggcggaagta cgatcaccca gcaggtcgtc 1863661 aaaaactccc ttctttcaca tcagaagacg ttgaaacgga aggtgcagga agtatggctt 1863721 tcgattcagc tggagcgcaa ttactctaaa gatgaaattt tagaaatgta tttaaaccgg 1863781 atttattttt ctcctagagc atacggaatc ggaaaagcgg cggaagaatt tttcggcgtt 1863841 actgatttaa gcaaattgac tgtcgaacag gctgcgacgc ttgcaggaat gccgcagagc 1863901 ccaacagcgt acaacccggt caaaaacccg gataaagcgg aaaaacgacg gaacatcgta 1863961 ctcagtctga tgaaaaagca aggatttatt tctgattctc aatataacaa agcgaaaaaa 1864021 gtggcagtga aagacgaagg cgtcgtgtca cagaaggaat atgaaaaagc aagtacaaac 1864081 aaatacagcg catttgttga agaggttatg aaggaaattg atgaaaaatc tgatgtcgat 1864141 ccatctgctg acggattaaa gatctatacg acattagata caaaagcaca agataaacta 1864201 gatgaattaa tggacggaga caccgtcgga tttactgaag gcatgcaggg cggtgtgacg 1864261 cttctcgata ccaaaaacgg agaagtccga gcgattggtg cgggacgcaa tcagcctgtc 1864321 ggaggcttta actatgctac tcaaactaag gcacagcctg gttcgaccat aaaaccgatt 1864381 ttggactacg gaccagttat tgaaaataag aaatggtcca catacgaaca aattgatgac 1864441 tcagcttata cgtattctaa cggaaaaccg attcgtgatt gggaccgcaa atatctaggg 1864501 cctatctcaa tgcgttacgc tctggcccaa tcaagaaata tacctgcttt aaaagcattc 1864561 caggcagtcg gtaaagatac tgctgtagac tttgcaaatg gactcgggct tggtttaaca 1864621 aaagataatg taacagaggc ctattctatt ggcggtttcg gtgggaacga tggtgtttct 1864681 cctctgacaa tggcaggtgc atacagcgcg tttggaaata acggaacgta taatgaaccg 1864741 cattttgtaa aatctatcga atttaacgat ggcacgaagc ttgacttaac accaaaatca 1864801 aaatcagcca tgagtgatta tactgcgttt atgattacag atatgctgaa aacagctgtg 1864861 aagacaggta ctggacagct tgcacaagta cctggtgtag aagttgcagg aaaaacagga 1864921 acgactaact ttgatgataa tgaagtcaaa aggtacaata tcgctagcgg tggcgcccga 1864981 gattcttggt tcgttggcta cacaccgcaa tatacagctg ccgtctggac gggaatggga 1865041 gaaaacgagg ctggaaagaa atcactttca gctgaagagc aaaaagttgc aaagcgcatc 1865101 ttcgcccagc tcatcgccga tgtcgatgac ggaagcggat catttgagaa gcctgacagc 1865161 gtagtggaag ccaccgtaga aaaaggttct aatccggcaa aactggcagg gccaaatacg 1865221 ccaagcgata agaagctcac agagtacttt gttaaaggca cagctccttc tactgtttct 1865281 aaaacatatg agaaagaaga aaaagaggaa acagctaaac tgtctggttt aaacgtgaaa 1865341 tacgataaag acaatcaatc tttaacgtta agctggaatt acgacggaga tgcgaccttt 1865401 gctgttaagc aatctgttga cggcggcagc tactcggaaa ttcaaaacag ctctgcaaaa 1865461 gaggcagtta tttcgggtgt gcagccagga tctgtataca aattcgaagt aacagccgtc 1865521 agtgatgatg gcaaaagtac agcttccaca tcttatgagg tgccaaaagc tgaagacgat 1865581 gaagataaaa aagaccagca acaaacggat gatgaaaaac aagatgatga gaagactcag 1865641 gatgatacac aaactgatga ttctcaaaaa gatgacggtc agacggatca agatcagaca 1865701 gatgattcaa caaacgatca agacaaaaaa caagacaata cgaacaccaa tccgtccgac 1865761 aacaataacc aagaccaatc aaacgataat gataacgaca acagtaacaa ccaggatacg 1865821 tcggatggtg attcgaactc tggtaagaat gattcaacag gttctgacac gaataaaaat 1865881 aaaacagaca catctaataa aacacaaaca aactcatcat ccattgaaaa aacaaattaa 1865941 acaaaaaagc cgtcaccttt ggggtgatgg cttttttggt acacaataaa aaacctcccg 1866001 ttttaacagg aggttttatc gattcatcgc atgatattta taaaaatgct ttttcatttc 1866061 ggtaatcagc tcatcaagct gaataaagca atggtattgg gtcggcttaa gaagaataaa 1866121 ttccactcgt tcagcccaat taatcggctt tgcgggatat gatttctccc tcagttcttg 1866181 ccaatcgagc gatttcaccg gctcacctgc tgtccaatgt aacgaagcca gcaaacacac 1866241 aatgcccttt aacatttcgt tttggtcaca tctcgatttt cgtgtttgaa agactgggag 1866301 aagtgatgct ttgatgtcat cccacacttc aaataaaagc ggaacgtatt tcccgctgtc 1866361 ctcccatggc aaatcgcctt gtaattccgt gcagaaatca aaatacacgg gattggtctg 1866421 caaggttttc ttcatatccg aggaactctt ctggccaaga ctgcgcaagt attgctcata 1866481 ggaagccaac acttcttttg cttgcgtcat cgtttcacca gtcctttttt atccctcttc 1866541 tgcccttctc tgcacaaaga aagcagcgga cactccgcac agcgcggaga ttgggcttta 1866601 cagtgatatc tgccgaagaa aataagccgg tgatgcgtaa cggaccaatc ttctttggga 1866661 accttgcgca tcagcgtctt ttcaacttcc agaaccgagt ccttccaccg gcaaatgccc 1866721 aatcgtttgc tgactctctc cacatgggta tctacggcta tggccggcac gccaaacgca 1866781 acggatacca ctacgtttgc ggtctttctc ccgacccctg gcagtttgac aagctcatcg 1866841 cggtctctcg gcacttctcc gccgtaatct tcaataatca ttttactcag cttttgaata 1866901 tttttcgctt tattacgata taaaccgatt gatttaatat cctgctgaag ctcttccagc 1866961 ggaacagcca aatagtcttc cggccgttta tatttttgga ataatgtttt ggtcactctg 1867021 tttacaagtg catctgtaca ttgcgcagat aaagcaacag ccaccactaa ttcaaaagga 1867081 ttggaatgaa ccagttcaca ctccgcatga ggaaacatgt cacctatctt gtctaaacag 1867141 aattcaattt gttttagatt taacacgatt gtcacctttt cactttattg ttcaagccaa 1867201 ttgtaaaaag gaacctgcct tttatactct ttttgcggtt cattctgctt tgcttgtaca 1867261 cgccggaatt tttggctgtg tatttttgcc tgctccacag ttttaagccc atttttcttc 1867321 cattcaaaca aaatccggtc aatgtagcgg aaactgagtt ttcctgatag tacagcctct 1867381 tttaacgcgt gtttgatcag ttgtgcgtca tgctgatcct ggtcctgcca gatcgccagc 1867441 gtttcacact ccaaaggcga taacggtctt gcgaactctt cctcaaaaat ggtataaagg 1867501 cttttttgtt ccccttctgc ttttctttcc tgtgtttgat tctgtgcaag ctgaatatac 1867561 tcgtacagct tgccccataa aggctgaaga gaatatttct caaatttgat gccgttttga 1867621 tcctcgcatt cttcaataaa cagaaagcct ttttgaataa acatccgcaa tctgtttgta 1867681 cattcttcaa cagaaattga cataccttcc tgcagctgat tcggtgtagg aaaatatgat 1867741 cctttttcta aatgcatttt aatttttaac agcagaataa gttctgtttc attaagccca 1867801 agctgtttat aatgcgtgag cagaagattg gggatggttg atgttccctg ctcctgcata 1867861 tcaataaatt gctgtttttt catcgtcaca cctcttactg taaaggattg tgattgcccc 1867921 tttactgtaa aaagtctccc ttgcaggaga ctcttttttg tttcatttga atgtattacg 1867981 gatacagacg gtttaacagt cttgggaacg gaatcgtttc acgaacgtga ggcgctccgc 1868041 tgatccaagc tactgtccgc tctaatccaa ggccgaagcc ggaatgagga actgatccat 1868101 attttctaag ttcagcatac catttataag cgtcagaatc cagtccatgt tctttaagac 1868161 gcgattccaa aagttccata tcgtgaatcc gttcagaccc gccgatgatt tctccatagc 1868221 cttccggcgc aatcaagtca gcgcaaagca caacgtcctc acggtcagaa gccggctgca 1868281 tatagaacgg ttttaaggac gtcggatagc gagtgatgaa taccggtttg tcataatgtt 1868341 cagcaatcgc tgtttcatga ggcgctccga aatcatctcc ccactcgata tcgtcaaagc 1868401 ctttttcttt cagaaattca atcgcttcat catacgtaat tcttgggaac ggggctttga 1868461 tttgctcaag ttttgacgtg tctcttccca atgtgtttag ttcaattttg caatttttaa 1868521 gaactgattg cacgatgaaa gaaacgtaat tttcctgtac ttgaaggttt tcttcaaatt 1868581 ctacaaacgc catttccggt tcgatcatcc agaattcgat taagtgacgc tttgttttag 1868641 acttttccgc tctgaatgtc ggtccgaaag agaatacttt tcctaaagcc attgccgcag 1868701 cttccatgta gagctgtccg ctttgagaca gatatgcatc ttcatcaaag tactttgtcg 1868761 caaagagttc tgttgttcct tcaggtgcgc ttccagtcaa aatcggcgga tccactttta 1868821 cgaagccttc gttattaaag aattcgtaag tcgcgcgaat gatttcatta cggattttca 1868881 tgatcgcatg ctggcgcttt gaacgcagcc ataaatgtct gtgatccatc aaaaattccg 1868941 ttccgtgttc ttttggtgta attggataat cggtcgcttc gtgaatgact tcaatatctg 1869001 tcacagcaag ttcatatcca agcggagaac gctcgtcctc tttgacaatc ccttttatat 1869061 agagcgacgt ttcctgcgtc actgatttag ctgtttggaa aatgctttct tccacttccg 1869121 cttttactac gacaccctga ataaaaccgg taccgtcccg aagctgtaaa aacgcaattt 1869181 tcccgcttga acgcttatta gcgacccaag ctccgatcgt tacttcctca cctacgtgct 1869241 tgtacacttg gttgattgtt gttttcaaca tatttccctc caaaacaaga aagacattcg 1869301 gaagctcatt gccccgcgaa ctcttttatc atcactttat tatacccgct cttaactaac 1869361 cgggtcaatg cagataaaaa gcggcttttc tgtcagccgc tttttgatct gttagctatg 1869421 tttttctaca aaacgcttga ttctttcaat ggcttcttca agaagatcta acgatgttgc 1869481 ataagaaaga cggacattct caggagagcc aaatccggat cctggaacaa tcgcaacttt 1869541 ttcctcctcg agaagcgctt taacaaattc atctacatct ttgaaaccgc aagattgagc 1869601 tgcctctttt gcatttggga acaagtaaaa agcaccttcc ggcttcacgc agctgaaccc 1869661 tgggatttct atgagctttg catagatcgt atttaatcta tgttcaaatg cttctctcat 1869721 ttcttccaat ggctcagaag gcccgttata agcagcaatc gctccgtatt gtgcgattga 1869781 tgtcgggttt gacgtgctgt ggcttgcaag gttcgtcatc gctttaataa tgtcttcaga 1869841 gcctgccgca taaccgattc tccagcctgt catgctgtgg gacttcgata cgccgtttat 1869901 aatgaccgtt tgctctttca gtctgtctga cagctgtgca atggaaacat gtttctttcc 1869961 gccgtatgta agtttttcat aaatttcatc tgacacaatc aagatatcat gttcaaggca 1870021 cacttcaccg agcgcagata gttcttcttc cgtatacatg acaccagtcg ggttgcttgg 1870081 agagttaata acgattgctt ttgttttttc cgtaattgca tttttcagct gctcaggcga 1870141 aattttgaag tgattttcct caagcccttc tacataaaca ggctttccgc cagcgagttt 1870201 cacctgctcc gggtagctta cccagtaagg cgttggaata ataacttcat cttcttcatc 1870261 caaaatcact tggaaaaggg tatacagagc atgtttggca ccagtgcaga caataatttg 1870321 agacggtttg tattcaatat tctggtcgcg tttaaatttc tctgcaatgc tgtttttcag 1870381 ttcagccaaa ccaccggaag gcgtgtattt cgtatggccc tcgttcatcg aacgcacagc 1870441 ggcatcaata atatgctgcg gtgtattgaa gtcaggctcg cctgctccta agccgatgac 1870501 atcatggcct gcggctttca gttctttcgc tttcgctgtg attgccagtg tggttgatgg 1870561 tgttaatgcg gatactcttt ttgccagttt caacttgaac tccccctaat tcgtcttaag 1870621 gcgtgatatt tttgagaatc tttccagttg taaagtccac ataacttaaa ctgtattgcc 1870681 cttctttgtc taagtacgtc acttcccaaa gcaggacgtt tccttctctt gccagatgaa 1870741 cctctttttg ctttgaaacc agcccttcat cctttatgat tttcgccgct ttgtcttcag 1870801 agattccctc tttcgcttct tttgagagaa tttttgcttt tttatcagca ggaacccaga 1870861 catataatgc agtgcctttt ttatccgttc cctttacaac ataatatttt tcttttccga 1870921 caaatgtttc gacttgatca acatgggcga gatcggtttc ttttttagct tcagcagctg 1870981 ctgcttcgtg cccctcttcc ttttgtgcca tggctgattt ataaatgctt gccgagacaa 1871041 gaagtactgc taaaaaaata ataccaaaaa tgacggtaaa tattaatgct ttttttctca 1871101 tcttctcacc tacgtacgat aaatggtaaa aacggcttgg tttttgtttt cttcatccag 1871161 cgcaaggccg aacatcagat tgtctctttt cagtgtacga ttcaatgtgt ccacaatttt 1871221 atacagatca tcagaatgct ctacattaat tgttgaaaga atttcgattt tactttccat 1871281 tttttcatcc tccagtttga acaaatattg ttagtcatac tccatttcag gacacgccat 1871341 actagtatca cagagcggga aatccgcttt taaataaaac accatcctac tcccacaccg 1871401 caaaagccgc tttatgcggc ttttattctt tttcccctgc aacataagct tcaagctcgc 1871461 tgtcagtcat ttcggatact gaggttgtcg gcaaggcatc aagaaacagc cggccgtaac 1871521 cagcggtttt aatccgtctg tccaatataa taatcgttcc cttgtctccc gcagaacgca 1871581 gcaagcgtcc gattccttgc ctgaaggtca gcacagcttc cggtaatgac actgtttgaa 1871641 acggattctt tccttttttg cgggcaagct cacattttgc agcatgaagc gggtgatcag 1871701 gggaccggaa tgggagcctc acgatcatta ctgtcgtcag ctcatcacca gggaaatcaa 1871761 cgccttccca aaaatgattt gttccgagca ggatcgcctg attggatgtt ttaaaagtct 1871821 tcatcagttt gccgggactt ccgcctgtaa tcccttgtgc caagagctga atgccggaag 1871881 cactcatgtt atgcttaagc tcctggtgaa cctttttcag catatcatgg gatgtaaaca 1871941 gcacaaggat tttaggctgt ttttcctttg ccatcagttc gatataacgg gctgtatcct 1872001 gtataaattc aggttgccct gtatcctgaa ttgatttcat ttcttttgga atcatcacct 1872061 gcatacgctc atcgtaagaa aagggtgact caattctcat tgtccgcggg aaaaagtcac 1872121 tcagtcccag tcgttcaatc ataaattgaa aagaaccttc gactgtaaga gttgcagatg 1872181 tcagcaccac actatttttg cgcgcgaaaa actgatcagc cagaagttca ccaggttcaa 1872241 gaggctgtgc gtaaatggcc actgcatttt tcgcaccctt tgcatctatt tcaatccaaa 1872301 ccgcttcatc gtcatcagag ccaaagaaga gcttctgcaa cgtctgacag taatgctgca 1872361 agcctttcat gcttctttgg tattcatcgg ctaaaaagac ggttttgctc ttcatgccct 1872421 tcaaatgttt ttccataagg gatgactgcg cctcaaaaag ctgctgcaaa tgtgtcagca 1872481 tggaacaaag cctctccgca ccatctgtta agatcgacca gcttttatcc tggctttctt 1872541 tgttcacctt aaacactaga cggtttaagt cttctttagg ttttcttcgt ttgacaaaag 1872601 aatgtacaga gctaaagaaa gcatcacttt ctgcttgaac gtgctgaagc cactcttcca 1872661 attcgaaaaa tgaatcaacc ggcaggctgt ttcgctggaa tagctgtctc atctttttta 1872721 gaagtccctg ctccttcaga gtgccgattc tgctcaattt cgtatgcaat tctatgtacg 1872781 tggctctttt ccctaaatgt tcgcttgccg cacgttcaaa atggtgtgct tcatcaataa 1872841 taaatgtgcc gctttcggga agcctttttt tatggctgcc ttcatcggtc agcaaaagag 1872901 aatgattggt gatcaccaaa tcggaacgca tagcaatctg tttggcccgc tcgtaaaaac 1872961 cgatcacatg ctcactgcga cttcttttat aggagtcatc gtcataagcc aatctgtccc 1873021 acagcaattt tccgcctgaa ggcaaattca gttccgctac atctcctgta tttgtctctg 1873081 tcagccaaac aagaagctgt gcctttgtca gtacggcatc ataattatca tcttcttcat 1873141 gaagcacctg ctcaaattta tacaggcata aataatgcga ttgccctttt aaaatcgccg 1873201 ctgttaccgg aaatggaaac agatcttgga caatcggcaa atcctttgtg agaatctgct 1873261 gctgtaaaag cgtcgaatac gtgctgatta tgaccggctt ttttgatttc ttggcaaaaa 1873321 gcgcagccgg aataagatag ccaatcgttt ttccgatgcc tggaggagct tcaatcagcg 1873381 catgctcacg attggcaaac gcatcagcca cctctctcat catcatcatt tggccgtctc 1873441 ttttttcata cccaggcatt aactctgaca gcgctttttc atttcccgct tcccagcttt 1873501 cgatctcaaa tgagaagttc tcgtcctcat ttatacgaac atcgatagct tcaggttctc 1873561 tgacagaaaa cgaagaaaag cgcgtatagc ccggtatctc ggtatgtctg ttttcattaa 1873621 tgaacatatc caacaaatgc gtcagatcac tgatgaaatg ctgcgaaagc cttcttaact 1873681 gctttaatgt cggataagga agctgccgca gcttttcaag gatttccaaa aaaataagcc 1873741 ctgtcacttc agcatcgctg tcagcccggt gcggctgatc atgccgcagc tgaagctcct 1873801 cgcttaattc cgtcagctta tacccttcaa atcccggaaa aacaatgcgt gagagctcga 1873861 cagtatcaag cacttcacaa tctgggagct gaaagcccgc cttatgtagc tcatacttga 1873921 caaatccaag gtcaaaatgg atattgtggg cgacaaaata agcgccgtca agcaattgga 1873981 atacttcttc agcaactgct tcaaatggct gttcattctc gaccatttga ttagagattc 1874041 cagtaagctg ctcaataaaa gcagggattg atttatttgg attaatgtat tttgaaaacc 1874101 gctcagtaat ttgtccattt tcgattacaa ccgctgcgat ttgtatgatt ttatcgcctt 1874161 tcttcggcga attccctgtt gtctctacat ctataacaac gaaccgttgc ttattcatta 1874221 aaatggacac ctcaattctt gcatacgaca aaagtgtaac acgttttgta cggaaatgga 1874281 gcggcaaaac cgttttactc tcaaaatctt aaaagaaaac ccccgataaa gggggctttt 1874341 cttctacaaa attgtacggg ctggttcgtt ccccagcatt tgttcaattt tgttttgatc 1874401 attcagaaca gccactttcg gctcatggct tgccgcttct tgatcagaca tcattttgta 1874461 ggaaataata atgaccttat ctccttcctg cacaaggcgt gcggctgcac cgtttaagca 1874521 tatgacgccg cttccccgtt taccaggaat aatatacgtt tcaagacgtg ctccattatt 1874581 attattcaca atttgtactt tttcattagg aagcattccc acagcatcaa tgagatcttc 1874641 atcaattgta atgcttccca catagttcag gtttgcttcc gtaacagttg ccctgtgaag 1874701 tttgccgctc atcattgttc gatacatatt atattctctc catttctcga atatcaataa 1874761 tgatattatc tattaaacgc gcttttgaaa aagcaactgc aacagcgaga atcatctttc 1874821 cagcaatttc attcacaggc tcgagttccg gataggaata aagctctaca tagtctatgg 1874881 ttccgctagt cgtttcaatg atatcttttg cagcttttat caccgcttca ggatctcttt 1874941 caccggcttg gacaagttcc gcacttgttt gaagggcccg atacagctta ggcgcttctt 1875001 ttctttcctc agctgttaag tatacattgc gagagctttt ggctaagccg tcttcctctc 1875061 tgaccgtatc gacaggaacc aattcaatat ccatgaagaa gtcgctgatt aacccatcaa 1875121 caacagctac ctgctgcgca tcttttaaac cgaaataggc acgagtcggc ttgactagat 1875181 tgaaaagctt cgtcagtacg atcgcgaccc cgtcaaaatg tccttctctt gagcgcccgc 1875241 ataacacgtc tgtgcgtctt tctacatgaa tcgtgacatt cttttcaccg ggatacatat 1875301 catgagcatc tggcgtaaaa agaatatcga ctccggcgtt ttctgcaaga gctgcatccc 1875361 gctcaatatc gcgcggatat gcttcaaaat cttcattagg gccgaattgt gcaggattca 1875421 caaaaatact cataataacg gcgtcgtttt cttgtcttgc tttgtctgct aaggttaaat 1875481 gcccctcatg cagaaacccc atcgtcggaa caaatccgat tgacttgccc tctgaatggt 1875541 attgttttat ggcttctttc agctgtgaaa tatcagtaat ctgtctcatc ttattttccc 1875601 ccgtacaagc cgtcaagcac tgtctggttc atttgaaagg aatgcttttg ttcagggaaa 1875661 gcacgatgtc ttacatcctg aacatatccg ctgattgctg tttcgatggt ttcatcaatg 1875721 cgcgtatatt gctttacaaa tttaggtgtt ctctcaacac cgtggccgat aatatcatga 1875781 taaacgagaa cttgtccgtc cgctttcaca ccagccccga ttccaatgac cggtatgctt 1875841 agcgtctcgg caattttggc tgtgagttct gccggcacac attccagcac aagcatcata 1875901 gctcctgctt cttcgcattt tatactgtct tctattaatt ttttggcgct ttgttcgtct 1875961 ttgccctgta ctttatagcc gcccagtacg ccgactgact gcggtgtcaa acctaagtga 1876021 ctgactactg gaatgcctcc aagcgtcaat gcgcgaatgg attcaaacac gccttctccg 1876081 ccctcaagct tcagtgcgtc agctccgctt tcctgaacga tagccgctgc atttttcagc 1876141 gtatcttcct tagacaggtg ataagacata aacggcatat ctgtcacaat aaaggtattc 1876201 ggcgcacccc ttttaacggc ttttgtatga tggatcatgt ccgcaactgt cacaccgaca 1876261 gttgaatcaa ggccgaggac gaccattcca agtgaatcac cgactaaaat catgtcaact 1876321 cccgcttgtt cagcaagttt agctgccgga taatcataag cggtcagcat gacaatcggt 1876381 tcttcagact ccttcatttt tagaaaatcc agttttgttt tcatgttttc tcctcctcat 1876441 gtttagagga gatgatctgc cgttttcttc tgcaagccaa aaaaccttcc gttacaacga 1876501 gaaggattct tcactttcta aagttcggcg agtttcatcc ctctgtccca gtcctttttt 1876561 ggatcaaggc agactgctgc aatgtctatc tattttaata ataggtgcag ttcgcaggcg 1876621 atactgccca atggaagtat accaaaatca acgggcttgt accaacacat tagcccaatt 1876681 cgatatcggc agaatagatt tttttaatgc cttcgttcgt ttctaaaagc agaacgcctt 1876741 catcatctat acctaacgcc ttaccgtaaa aggttccgtt taacgttctg gctctcatat 1876801 tagtgccaat accgagcgca tagctttccc ataaaagctt aatcggcgta aatccgtgcg 1876861 tcatataatc ccggtaccgt ttctcaaagc atagtaaaat atgctggatg acgccggccc 1876921 gatcaatttt ttccccagca gcttggctga ggcttgtcgc gatgtccttc aattcatctg 1876981 gaaaatcatt aggctgctgg ttaacgttaa tgccgatccc aatgatcact gaacgtacgc 1877041 ggtcttcttc agcctgcatt tccgttagga taccgactgt tttttttccg ttaatcaaaa 1877101 tatcatttgg ccatttaata tccgtttgga tgcctgctgc ctcttctatt ccctgcacaa 1877161 cagctactgc agcaagcaga gtcagctgcg gtgttttttg gagcggaatg tcaggccgca 1877221 aaatcaggct catccaaaca ccgtttcctt cttgagaatg ccatacccta gacattcggc 1877281 cccttccggc tgtttgtttg tcagccacca caagggtgcc ttccggtgcg ttattattcg 1877341 cgagctcatg agccgttttt tgcgtgcttg aaagaacgtc atggtaaata agatgctggc 1877401 ccatcacttc cgtttttaat ccaaaacgaa tttcgctttc actgagtttt ccgggttttt 1877461 tgatgagccg atatcctttt cttctaacgg cttctacttc ataaccctct ttccgaagct 1877521 cttcaatatg cttccacaca gcagttcttg aacagccgag agcatcactg attttttggc 1877581 cggaaataaa ttcattgccg gcctgagaaa ataattcaat aaggtctttt cttaatgttg 1877641 accgcatgtc ttcagccact cctctatgtg tttcttttga ttggagagct tccctgtcac 1877701 aacagcctgc tcgatccact gtaattcttc tgacacccat tttccggccg gccggtttcg 1877761 aagcgcaagc aagtccttac ccgtgatatc aagatcctta aggcttttga tcggcaggtt 1877821 ttgataagcg tactgaatgt ccttcagttt cttttcatcc agtttttcgt tttgccgaag 1877881 ctgcgatatt ttggccgctg agagcagtgc ttttttccca gctctgtaca ttgtcattgc 1877941 gtcaaggctc tggccaaacg tatcggcaat gtgaatggct tccttgatca cttttcccgg 1878001 gagcttccag gctttcagga aaaggggcgc gtctttcaaa actatgccaa ggttaattaa 1878061 aagagcagcc caaagctcct cacgggatgt taaagagaag aatggaaact cactcgttga 1878121 aatcaggttt tctcgtttat gataaaaacc aggaagctct tcatacaatc tcgtttgaat 1878181 gagtgtttga agcgcctggc gagaagctct tccctgcagc aatttctcaa actctatagt 1878241 ttttcgttcg actgaaacat gggagaggag tgatttttct ttcgcaatgg cttcttctgt 1878301 ttccggtgaa agcgtaaagc caagctggct cataaagcgt acggctctca gcatacgaag 1878361 cgcatcctct tgaaatctat cctcaggctt tccaacggtt cgaatcactt tctgatcaat 1878421 atctttcttg ccgccaaaat aatcaagcac cttcccgtcc gctgtcatgg ccatcgcatt 1878481 gatcgttaaa tctctgcgtt ttagatcctc ttctaatgat gagataaatt gcacttctga 1878541 cggtcttctg aaatcaacat aatcagattc agtccggaat gtcgtgactt cataggtttc 1878601 atcctcccag agcacaataa tggtcccgtg ctctttgcct acatcaacag tccgctgaaa 1878661 cagccgttct acttgatcag gtgccgcatc tgtcgcgata tcgacatctc cgatcgttcg 1878721 tttcatatag ctgtcacgaa ctgcgccccc gacaaaataa gcctgatggc ccgcttcgat 1878781 taagatgcgg agcacgggaa gtgctttgat aaaaactttt tccatgtgat cactccggtt 1878841 ctgctaaatc ggcataaatc tgttcatact ggctgacaat ttttttagaa gaaaattcat 1878901 tttcaagcat ctctattgcc gcctttgtaa aacgattgct tagctgttca tcttctaaaa 1878961 tgctcatcgc gcgggctgtt gcggccgtaa catcaccgac atccaccaaa aatccgctca 1879021 cattgttttt tataacctca gggataccgc caatgtttgt tccaatacaa ggcactccgc 1879081 aagccatcgc ttcaagcagg acaaggccaa agctttcttt ttcagatagc agcagcttca 1879141 aatcgctaat agaataaaga tcttcaacac ggtcttgatt tccaagcatt aagacttggt 1879201 cttccaagcc atattttctg ataagctcgc aggctgtcga tttctccgga ccgtctccga 1879261 ctaaaagcag cttcgctttc gttttgccag cgatattgcg gaacacacgg atgacatcct 1879321 gcacgcgttt aacttttctg aagttggaca catggatgac gactttttca tctggtaaaa 1879381 ttccatgttt ctctttaatt gccgctgtgt ttttcttcag atacacgcgc tcgtctataa 1879441 agttataaat cgtttcaatt tttttctccg gtttaattaa atcgtatgtt tcagccgcaa 1879501 gcgctgagga gacggccgtc accctgtctg atgactcaat agcaaaacgg atcagatctt 1879561 ttagagacgg atcataacct aacaccgtga tatccgtgcc atgcaaagtg gtaacaatgc 1879621 cgatattgcg tttcagcatt tgttttgcaa gataggcgca aacggcatgc gggagagcat 1879681 agtgagcatg gataatgtct aaattctccc gttccgccac ctcagcgatt ttgcttgcca 1879741 atgtcaaatc atacggagga tacttaaaaa cagcatattg attaacctca acttcatgaa 1879801 aatgaatatt gggatgatat gtattcagtc taaacggaat gcttgatgtg atgaaatgga 1879861 tttcatgtcc cttttcagca agctgcttcc ccagttctgt cgcaatgata cctgagcctc 1879921 caacgctcgg atagcatgtg attcctattt ttagttttct cattgttcgc ccccaagcac 1879981 atcatgatca agcatcagca tccgtttgga aaagaaacct tcggcatact ccacgcccgc 1880041 ttctttaccg taaagctttt ctctcgcttc aacgatttca atatacccat tcgtcagagg 1880101 agtagaaacg gaatcctttg acgggataaa ctggcttttg taggcgttga ggctttgttt 1880161 ctttgcctct attgtatccg agatatcaat aacaaaatcc ggctgatgaa aaccatttat 1880221 catataatag taaaccttgc tgactttatg cgccggaagg cttttttcgt ctttatattt 1880281 atggattccg gcggaaaaga tcgcttcttc caccagtgca gccgcattgc cgtgatccgg 1880341 atggcgatcc tttttatacg gcataaaaac cgcttttggc cgacagattc tgatgacagt 1880401 gacaattgac cgaattgcct gatcactcat tattaggccg cggtctggaa gcgttagctg 1880461 aattctttta tctgcgccta atatgcgggc tgcttcagct gcttcttctt tacgcaaact 1880521 gaccgtaccg ttagaagaga gttccgcttc tgtcaaatcg catatcatta cttttttttc 1880581 ctgtttgaca aacttcgcta ttgtgccgcc cattccgatc tcgacatcat cactgtgggc 1880641 gccaaaagca agaacgtcag cattatacat tcggctcttc tccccgaaga aggtcacgga 1880701 attcgaaaac accttcatca agtgtgcgca caagaatttc cgcagtaccc atatttgtgg 1880761 cgagcggaat ggaatacaca tcacataaac ggattaatgc cgagacatcc ggttcatgcg 1880821 gctgcgcggt cagcgggtcg cgcaaaaaaa tgacaagatc gagtgcattg gcagcgatca 1880881 gtgcaccgat ttgctggtct ccccctaaag ggccggattg aaaacgttca atttgaagac 1880941 ctgtcgcctc atgaattttc aaccctgtgg ttccggttgc gtatagatca tgattcttta 1881001 aaatatcccg ataggcagtc gtaaattgaa ccatatcctg ttttttcttg tcatgcgcga 1881061 tcaaagcaat tttcattgtt tatccccccg tctaatcaat gatattttct aaaccataca 1881121 caagctgatc aatcttcatg acttgttcga ctgacagttt aacgcctgac atgaaagaag 1881181 cacggttata agaatcatgg cgtatctgaa gcgtttggcc atccatgccg aacatgacct 1881241 cctgatgcgc gatcagtccc ggaagacgga cgctgtgcaa gcgaataccg ttttgctccg 1881301 ctcctcttgc tcctgggaga atttcttttt catccggatg tccttgctgc ttttctttac 1881361 ggacttctga aatcatttcc gctgttttaa gcgcagttcc gcttggtgcg tcaagcttct 1881421 ggtcatgatg aagctcaata atctcaacat cctcaaaata gttggcagcc atttttgaaa 1881481 atttcatcat cagtatcgca ccgagcgcaa aatttggcgc gatgatggct ccgatccctt 1881541 tttcttctgt taaagatgtg agctctttta aatcagcttc tgagaaaccg gttgttccga 1881601 caactggacg gactccgtgc tctaatgcaa tttttgtatg tacttttccg atttcgggcg 1881661 ttgttaaatc aatcaagaca tccggttgtg tttctgtaaa acaggcatgg atatctgtgt 1881721 aaatgaaagc atctgactca acaggcatca catcagataa tttttgctga tcgtatgtat 1881781 ggtctatggc ccctacaagg tcaaaatgtg gtgttcgttc tgccaattta acagcttcct 1881841 gccccattct tccacgcggt cccgcaatga ctaatttaat tgtttcgttt gacatcttga 1881901 tctcctctac tttccttctt cttttctggt ccagcgatct ttatctcttg tattaaattt 1881961 atgcatgact cggtcgtgag cttcctctaa agagatatca agagagttgg ctaaacaaac 1882021 caatacaaat agcacatcgc ctatttcctc ttccatgctt ttatcatctt cagtcgcttt 1882081 ttttggtttt tctccataac ggtgattcac ttctctggca agctcgccca gttcttcagt 1882141 cagcctcgcc atcatggcca gcgggctaaa atatccttct ttaaattggc ctatgtaacg 1882201 gtctacttca gcctgtatgt ctttcattgt tttatcactc actgaacgaa acctcctatc 1882261 atcctcttac atgttagcta attcagatac gtttgacaaa tgtttaagca cgtttgctgt 1882321 tttctttttc atccactata atataaacgc tatctaatgg aaggaaaagg ggttttgtgt 1882381 gatgcttgga gaaattagat taaaaaacat attttttatt ttaatcggag cggcaatttt 1882441 ttcatttggc ttggttcatt tcaatatgca gaacaatctg gctgagggcg gttttacagg 1882501 tattacactt ttgctttatg cccttttcca catcagcccc tctatatcga acctggtgtt 1882561 gaacattccg atttttttta ttggctggcg tttgctcggc aggacaatgt ttgtttatac 1882621 ccttgtcggc actgtagcct tgtctttgtt cctcagcatc tttcagcgat atgaaatcca 1882681 tatgcccctt cagcacgact tagcgctcgc cgctttattt gccggcgtat tcatcggagc 1882741 cggactgggt attattttta agttcggcgg tacgacaggc ggtgttgata tcatcgcacg 1882801 tttagtgaat aagtattttg ggattccgat gggcagaacg atgtttgctt tcgatgcctg 1882861 cgtcatcatt ttgtctttgc ttacttatct ctcctataaa gaagcgatgt atacgctggt 1882921 agctgtattt gtagcggcaa gattaatcga ttttattcag gaaggcggat acgctgctaa 1882981 aggcgctacg atcatctctt cgaaaaacga cctgattcag aaaaagattc ttgaagaaat 1883041 ggaacggggc gtcaccattt tgaaaggaca aggttcctac acaaaagagg atatagatgt 1883101 actttattgt gtggtgccga aaaatgaatt ggtgatgctg aaaagcgtga ttaactccat 1883161 tgatccccat gcctttgtag cggtaagcga tgttcacgat gtgctcggag aaggatttac 1883221 gcttgatgaa aataaaaatc cgcttccgcg ctgacatgta atagaaaaaa ggcggctgac 1883281 cgccgcccct catccttatt tagggtagtc cctttttttc agcttgtttt tttccgcctt 1883341 gtactttctg taaccgacat aggtaagagc agtaatgatg atactgccgg ttgtaatgat 1883401 cacccagagt aaagacggat cggcatcatc ctcctccacc ctgtcaaaca catttttcag 1883461 gtcatgctga agaagggaaa gccgttcaag cttcgtgctc tctgtcattt gctgaaattc 1883521 ctcttgctca ataacatcta tatgttttcc gactgtttca agctgatcct ctgatacatc 1883581 gattgtaaga ctggggtaaa tcaagtcata taaactgata aattcattcc atttttcatg 1883641 aaagcttgtg cttccattct tttggacatc tcgcttcagt tcagtaaaag cttccataat 1883701 cggtttttcc agtgagcccc aaagcgggtc agaccgattg tcaaccgcat ccatcagcat 1883761 tctgaactgc gcggctgctc tgagtttttg tgtgtctgat gtatcagctt gctttaaact 1883821 ccgaaccata tcattatagc ccaatgtgat ttgacgaatt tgggctcccg ttagcatggg 1883881 gtcttgctgt tttttctcag cggattttaa tgttttttca aaatactcca agacttgaag 1883941 cgcctcttca tatttcgcct gtcgggtcat ttgaaagact gtatcggata aatcattcaa 1884001 ttcctcgagg cttccccgct ctgcagcctt ggcatttcca ttataaaaaa taagtgcaat 1884061 caacaaacag atcgtcagct ttcgtttcat gcaggtccct cccactctct ctccttacag 1884121 aatatgaaga aagggacaag gatagaccaa cattgtcttt acatcagctc aagcttcgtt 1884181 tgcttttttg agaccacaag aaagtaagca agcgcgattg aaaagatact tagccaaaat 1884241 gttccgtatc ctatttcagt catataatca gaaagcatag agtattgcgg catcatatca 1884301 aacaagtagt caatgacatc gttatgcagt gtccagactg cagcaattgc aagatgccaa 1884361 aatgaaaaac gaaaatacgg actgtataat acgccttgaa ctgccattgc aaaatgcgaa 1884421 gcaattagca tgtagccctc ccacggcaag tcaccagtta ctgcaagcac aagaaaattc 1884481 atagccaccg cccataggcc atactttacg agggtaacta gcgcaagcgc ctctaaaagc 1884541 ggagcattcc gtttcatgag aaaggcaagc agcacaaaca gaaagaaaaa cgttgctgtc 1884601 ggactgtccg gaacaaaaat caggaaacgg gccggtgtct ccaaaagctg cggcaagtac 1884661 caatagtagc cgtaaaccgt tcccagaaaa ttaatggcta agacaagaat aagcatcggc 1884721 cgctgcccta atacatattg aaaccatttc acatcgaatc aactctcagt ctgtaaaaat 1884781 aatatgtcca tataaaaaag ctgacgccgg gtcagctttt gataataaaa gtatatcctt 1884841 ccatttgaca attcacaata cgttattttg cggttgtttc agaaataaat tttgcaagtt 1884901 cttcgagctg cttatcattt cctttgaaca cacccgccgg cattttgcct ttcccttcta 1884961 cagcgatttt tttgatttca tccggtttca gcccgctgtc aaccaatgaa ggcccggccg 1885021 ctcctccctg aaggttatcc ccatggcaag aaatacagcc ctgttcctta aaaaccttat 1885081 atccttctgc attggtgtca atgtcggctt cttttgtaat tttcccctgt tcttctgcct 1885141 tggcccagtc atgagtagca actgactgcc acgtcaaaaa tacagcagcg gaaatggcca 1885201 gaagcatcat accgacagcg accggacgct tccacggcct tctttctgtc cctctgtcta 1885261 ggaatggagc caaaagcagg gccccaaaag cgagacctgg cataatcatg gcgccgacca 1885321 ctgtaaagct tccggcggcg tattcatact tcaacagctg gtataagaaa agaaaatacc 1885381 aatccggcag cggaatataa ccagtatcag tcgggtccgc catccgctct aaaggcggct 1885441 gatgcacaat cgtcaaaacg agaaaaccga tgagaaagac agctccaacc atccattcct 1885501 ttaacaagaa atttggccag aaagcctctg ttttacccgg atactccgaa taatccttcg 1885561 gtatattcgg ctttttttca gccggtatcc ttgagtcgcc tacaaatttc atccctttgc 1885621 cccggtgcat gtcatcccct cccttttatt cgcagatcaa gagtttaaag cggtcctgaa 1885681 atcccctgct tccggatcat aataaaatgt gcagccatca gcccgaacaa tgcggcagga 1885741 agaaaaaata catggatcgc aaaaaaccta gtcagcgttt gggcgcctac aatatccgga 1885801 tgccctgcaa ggagcgtttt aacttgcgtt ccgatcaaag gcgtggcttc ggcgatctgc 1885861 agtccgactt ttgttgcaaa cagagccttc atatcccaag gaagcaagta gcctgtaaag 1885921 ccaagaccga gcataacaaa aaagatcagc acaccgacaa tccagttcag ctcgcgcggt 1885981 tttttatacg cgccttggaa aaagaccctc agcgtatgta aaaacatcat cacaatgacc 1886041 aggctcgcac cccagtggtg catccccctg acaatctggc cgaatgccac ttcattttgc 1886101 aaataatata ccgattccca ggcatttttg atatcaggca cataatacat cgttaaaaac 1886161 attccagata atacttggat aacggttaca aaaaacgtca gtcccccaaa gcaatacaca 1886221 aacgcagaga aatgatgggc gggattcaca tgttccggta cttcgtgatc ggcaatatcc 1886281 ctccacatcg gtgtaatatc aagccgctcg tctacccagt cataaatttt gttcagcatg 1886341 tcacccttcc cccttaggct ttgcttttcc aagatacagg aagccgtctt ttacttcttg 1886401 ctcataatga tcaagaggcg caagcggcgg cgtgccaggg acattggtgc cgtccttttc 1886461 atagagtccg taatggcatg gacaaaagaa tttattcggg tttttaggat cactattcca 1886521 gttcaccgta caccctaaat gcttacaaat tggcgaaagt gctacaattt catccccgtt 1886581 tttgaagacc caggctgatc ttgactcttc tgactcatac caggcatcga cttgattaat 1886641 tttaaaatca aagcgctgcg gctcttttgt caactcatca acgctgacaa cctgaaccat 1886701 atcctgcttc cctgtcgatt ttaataccgg gtcgagtgcg aagcgaacca taggcatgag 1886761 catactagcc gccataaaac ctcctacgcc tgtgagcgta taattcaaaa attgacgtct 1886821 ggatatatca tgttttccgc ccatctcttc tcccccctct aagtcacccc tgcaaactga 1886881 ctaaaataga aaatattgca ataactctag acaccctcat aatatatgaa tctctcagca 1886941 aggtcaatat agccaaaata ttgtttataa ggaaatgtaa gtgtttttat aaagtgctcc 1887001 ataactgtaa caaaacgttc aaaatttcag cagtgcgttc atccaatatt tttcttttta 1887061 aagagtcatt taaatgctct aatggaacag acgatgtaac aatcattttg cctaacgcat 1887121 cctcagctct ccaactttcg tcagatgtga gcaggacaac atgcggaaat tccgttatca 1887181 gctcttcccg caaatcctta agcccttgaa cggttatttc atttctatca acatatgtat 1887241 aaggcggaag taaatatacc cgtcccttta actgcctttc aagttcttct gagagaagct 1887301 gcgtaaactc gcctttctcc gccgccattt taaaatggtt attaaccctt atgttaatta 1887361 atggtatgac agcggtatca atgtaatcct tagcttgtaa atagtccttg gcatcagtga 1887421 ttctccacct catcgttctc cccctttacg gcaacaagcc ttgcaattca ctgcaaggct 1887481 ggtcatatta tgtgagctga tttaattggc gcgataattg ttcaaatgcc tctttatcat 1887541 gacgatctaa cgcgtcgtca atgtctttta ataatttttc tctttggaat gtggaaatag 1887601 cgtgctctaa aatctgttcc gccaatccct gatctttttt attctcaaaa aggtttttcg 1887661 gaatatgcgg gttggactcc agcaccgccg catattcagg tgagctgtaa gccgaacgga 1887721 aattaagctg gataaacaaa tcctgctgtt tatttaatct aatatcatga aaagattttt 1887781 ccgcgtcggt agtcatgaca ttctctttat agaaccggaa cggaacttct tcaacacaat 1887841 gtgttgacat tataatgcct ctcgggcaaa attcagcctg ctccacaaaa tgaaccttct 1887901 ccatgagaga atcatggctc attaagtagt tcaagatcca aacgcactct cggcgcttta 1887961 actgataatg gtttaaaaac caacggataa aatctttttt ctcattgaca gaaacagggg 1888021 tctgcatgta attccctcct ctatcgttcg tataatctat atacttatat gttccacatg 1888081 aatggttaat attcctgctt atctagaaaa ttcatcctcg attcgcaaaa tcgtttcttc 1888141 aagctcttca ttggctccgt ccatttcaag aacctttttc aaaagcggca gcgcttcttt 1888201 ttgaagacct tcttctaata ggaagcttgc gtattcatat aagaaatctc tatcctcccg 1888261 gtaatgaaga taggcagcct caaaggattg ttttgcttcc tcgtattgct ctaattcagt 1888321 atatgcgctt gcaagatacc aattgtattt aggatcttct tcaccgtagc ttcgaacctc 1888381 ttgaataaga tcaatgatct gatcataatc ctcttctttg tgatacacgg caagaagtgt 1888441 atgaagcgcc tcgacaaagc ccggatcaag cgcaagcgcc tcctgaagca gcttcttccc 1888501 ctcttctgac ttcccgattt tcaaggccat tttggcggca taaaggaaaa gttctttgtt 1888561 atattcatca tatctgatcc cctcttttgc cgtttttaat gcctcttcat acattccttc 1888621 agcttcatag cttttcgaga gcggcatata aagtgaagta taagatggat caagctcctt 1888681 taaatcagac agctgcttaa tagctgtttt cacaagcccc gcctgtaagg ctgtaaaacc 1888741 atagccgaaa atcgtattag gatcaggatt ctcatcgaca gctttctcat accatggaat 1888801 ggcatcctca aattcacctg aggcacttaa cgattctgcc agtctttgat ggacattaac 1888861 gcccccgatc tcactctgct cctcagccgt tgttttaaaa tattgaaccg cttttgcata 1888921 ggctccctga gcaaagtaaa gttctcccag tgcaaaatca ataacaggtt cattgtccag 1888981 aatggacttt gcctggaaaa gcttttgttc actgacttcg aataacccct gcatctgata 1889041 aagatccgcc ataagcagca aactttccgg atatgatgga tctgtttccg gaatagtctc 1889101 cagcacagcg agggcttttt cttcttcgtc aatatctatt aaaagttcag cgtagaaatt 1889161 cgtcagttct gtttcatttg gatataaatc atgtagatca ctaatcagtg aaatggcttt 1889221 ttctacatcg ccccactcgt aataaagctg ggctgcaatg gctttatctt catcatgcag 1889281 ctgtttttca gccttcgaga gcgtgttgag gcctttttct gtttcacctg cttcaactaa 1889341 ttttatggct tcttgaatca atgtattcaa atcggaccgg tcctttcttt tcctatacaa 1889401 catcaaccat acaaaaaaag ctttatttgt tcgggttaat cttatcataa ttcagacgaa 1889461 tgcccccggc aaataagatg cttctgtacg gaagggaatt attgagtctt attagtttac 1889521 caaaagatct tgagatagaa aatgaaaaaa ggaagatcgc cctctgtaca gtaaagcagc 1889581 tctttgacct gccggcttgt aagtaaagca catcccccct tttcgttttt ctatccgttc 1889641 tataagacaa gctatgtttt ttcgcctcga attatgatct gcataaaaaa tcctgaagta 1889701 aaacttcagg attttttcga aagcttattt aaatgctcga agaaggttgg ataagaaacg 1889761 tgaatggcat ccgtgtgctc gatttcaatc ggctcctccg ttatacagga agcaatacca 1889821 agcatcattc cgattcgatg atctccgtgg ctggacactg cagcgccgcc tttcaacgtt 1889881 tgtttgccat aaaccttcat tccatctgct gtcggttcaa tttcagcacc cagcttgcga 1889941 agctcagaaa caacagtatc aatacggttt gtttctttca cttttagctc tgccgcgtcc 1890001 ttaataacgg tggttccttc cgcctgagtc gcaagaagcg cgatgatagg gatctcatca 1890061 attaaacgcg gaatgatatc tcctccgatt tcaactgcct ttagagatga cgtttctata 1890121 atcaaatctc cataaggctc tgcaccgcta tcagcagatg gtttgatttc aagttttgcc 1890181 cccatgtttt gaaggacatc aataatacct gtccgagtcg gatttaaacc tacgtttttc 1890241 aatacaattc tgctgtttgg aaccatcgcg ccagcagcaa ggaaaaacgc ggctgaagaa 1890301 atgtctccag gaacaaaaat atcagcagct gtcagtttct ggccaccagc aatggaaaca 1890361 ctcgtttgat cttcagaaag cttaacgcca aaagcagaaa gcatccgctc agtgtggtcc 1890421 cgagatttat ggggctctgt tacagttgtt gtgccctcag cctgtaatcc ggccagcaaa 1890481 acagcagatt taatttgcgc gcttgcaaca ggtgatacat aatcaattcc ttttaatgaa 1890541 gcgccgctca ctgacagcgg tgtaaactct ccgccggctc tgccgtcgat tttagccccc 1890601 atttttttca aaggctcagt cacacgcttc attgggcgtt tcgcaatgct ctcatctccg 1890661 gctaccgcgc tgtaaaaagg acggcccgcc aatattccga gcatcaggcg aatcgttgta 1890721 cctgaatttc cgacatctaa aaggctttct ggctctttca gggcatcgat tccttttccg 1890781 tgaatcacga catcgctgct gctttgctca atgtgaacac ccatttttct aaagcaatcg 1890841 atcgtgctca gacaatctgc tcccggcaga aagtttttaa ctgttgttgt gcctgccgct 1890901 agcgcgccaa acataacaga gcggtgagaa atggatttat caccgggaat atgtatttct 1890961 ccatgtaagg tctgcacctt atctcgtttc attttttcca cctcaatcag cataaaaagt 1891021 ttcatattcc gcccgggctt caatgcattg ttctgccctt ttgcggtcgt catcagactg 1891081 aaaactgatc cttaaaatcc cgttaatatc ctctcgtgtt tcgataatgc ggatattcgt 1891141 gatactgatg cgctccgcag ctaagatcgc tgttatctcg gatattacac ccggatgatc 1891201 gggtacatcc acatataaat cataaaatgc aggtatcgct cccttctgcc gaagcggcag 1891261 cccgtcgcga taatccttgg ctgttttaaa ataacgaaat agattttccg catcttcttg 1891321 ttctacatat gtacggatct tgtcaatttc acgaatccac tcatcaaaac ggtctaagat 1891381 tttatcttta ttatgtaata aaatatcccg ccacattgcc gggctgcttg atgcaatcct 1891441 tgtaatatct ctgaacccgc cggcagcaaa acgcttaaca agcggataca ggttttccga 1891501 atgatgggtt tggtgaacaa ggctagctgc tacaatatgc ggaaaatgac tgattacgct 1891561 tgtaacgcca tcatgctcct ctggcgacat ttccacaaaa tgggcattcg tccccttcag 1891621 caggtttttt aactgttcca cagcttgttt gtccgttttc tggcctggcg ttaaaatata 1891681 aaatgcattt tcaaacagga actccttcgc agcggccact cctgatttat gtgaacccgc 1891741 catcggatgc cctccgacaa attgatagcg gctaggcagc acttgatcag cgtaatcaac 1891801 cactttttgc tttgtgcttc ctacatccgt aatcaaaagc tcatgttcaa ttcctgaatg 1891861 agccagctct tcaagcataa ccagtgtttg ttcaacaggt gtcgcaatga ttactgtagc 1891921 tgcctctttc acaccgctaa taaacgaatc agcacgatcg tctatcacgc ctaattttaa 1891981 tgccgctacc gcctgttcat cagagatgtc gattccgata atccgtttgc cgggatgatt 1892041 ttttttgatg gctagggcaa tcgaaccgcc tatcaatccg agaccggcga gcaatattgt 1892101 atctttcatt tgattcatac gtcatcacct ggtttataga ctaaagaggt gatatttgat 1892161 cacctcttat aaaatttcag ctaaaatggc aagtatttct tcattttgct cttttgttcc 1892221 gatcgtaatc cggagtgatg tcgggaaacc taatgcgttt cctgaccgga cgatatagcc 1892281 tttttccagc agagcctgaa acagttcatc agcaggacgt ttaaagtcaa ttaacacaaa 1892341 atttgtctgt gaagggtagc actttaaacc atgagttttc gcaaaatcat aatactgctg 1892401 aaggcctgca ttattttgct cgacacagga agcaataaac gcttgatcat caagtgctgc 1892461 aatcgccgca gcctggccca gacggctggt attaaacggc tctctcgccg gctcaatctg 1892521 gcgaatcagg ttctcgtcag caattccgta tccgactctg agcgctgcca gaccgtatgc 1892581 ctttgaaaat gtgcgcaaaa tcatcaaatt ggaatacttg cttaagagcg gcacggtttc 1892641 cgggtaatcc tctgctgtta catattcata atatgcttcg tcaagaacga caaggacacg 1892701 agaaggaacg cgctccagaa atgcgagtaa ttctccttca gatgtataag tgccagtcgg 1892761 attattcggg ctgcatatcc aaacgacttg tgtctgttcg tcgatggctt ctaacatggc 1892821 gtctaaatca tgtgagccgt cgggacgaag tgcaatttca cgtacttcag caccttcaat 1892881 aaccgcatta tgtttatatt gcggaaaagt gggggcagca gtaaccgtgt ttgttttatc 1892941 gtttaaaaat gcccggcaga tgatctgtat gatttcatca gaaccgttgc cgaaaataag 1893001 tgatgtttcg ctgacattga ggtgcttact gagccttgtc cgcaaagcgg cgctataccc 1893061 gtccgggtaa agggctagct gttgaatctc atgatgaagc gcctcttttg cagcctctga 1893121 acagccgtaa ggattctcgt ttgaagcaag cttcacaact ttatccaagc catattctga 1893181 tttcactgct tcaatcggct ttccaggctg ataaggcttc agctgtttta aatgttcttt 1893241 gatacgcaaa tcagtcacct cattttaaac tgtacaagcc gctaaacgcc attgcataat 1893301 cctcaaactc ctgcagcgcc tgatttctcg tttcagcgct gatgagccgg tcctttaatt 1893361 cttctatttt tctgacgagc gcacttccca ctacgacacc gtcactaatt tcattcatct 1893421 ttatgacctg ttcacggttt gatataccga accctacagc aaccggaaca gtgctgagat 1893481 tcttcacagt acgaatgaac gggtacacgg atgaattgaa ctcattgcgg acaccggtca 1893541 cacccagaga agatacacag tagacgaacc cctcggcttg ttcaataatg gttttcaaac 1893601 ggctttcgct tgtcggcgca actaaagaaa tatacgtcac ctcatggctt ttacattcct 1893661 cttgaaggct gttgctttct tctaatggca gatccggaac aagcagaccg tcaatatgat 1893721 tttcccgcag taaagcgaaa aagtattctt tgttcaattg taacacagga ttataatacg 1893781 taaagaggat aatcggaata ttcactccgt tttttttcat ttctccgcct aattcgattg 1893841 cctttacgat attcattcct tgatcaagcg cccgctttga agcccgctgg atcaccggac 1893901 cgtctgcaag cgggtcagag tatgcaacac caagctccaa tgctgtggcg cctgcttttt 1893961 ggagtgactt cgccagttca atcgaaacct caggaactgg atcgcccgcc gtaataaacg 1894021 ggataaacaa tttttctgat ggttgaagat ccaatttaaa catgggcttt cacctcttct 1894081 tccaatacat tcattaatgt gttgacatcc ttgtctcccc ggcctgataa acagacgaga 1894141 atgagttgac cgcgatccat tcctttggcg agtttgaatg ctttcgctaa cgcatgggca 1894201 gattcgattg ccggcaaaat cccctctttt tctgacaaaa gctttaatgc atccaccgct 1894261 tcttcatcgg ttatactgtc ataagtgaca cggccgcttt tatgcaaata tgcatgctcc 1894321 ggaccgattc caggatagtc gagaccggct gaaatagagt agggctcaat aatttgcccg 1894381 aactcatcct gaatgagata agtcaatgaa ccgtgaataa cccctacggt tcctttcgaa 1894441 atagtggcgg catgaagagg tgtatcaatt ccttttcctg ctgcttcagc gccgatcagt 1894501 tcaacatctt catttaaaaa tgcctgaaac atacccatcg cattgcttcc tccgcctaca 1894561 catgccacta ctttatcagg catagtgcct tcaatacgtt tcaactgatc cttcgcttcc 1894621 tctccgatca ttttttgaaa ttcacggacc acttgcggat aaggatgcgg gccgacaact 1894681 gatccaatca tataaaagtg atcctcacaa tgctgaaccc agtaccggat cgcctcattt 1894741 gtggcatcct tcaatgttcc gtttccgctt gttacaggca ctacctccgc tccaagaagc 1894801 ttcatgcgga aaacgttcag agactggcgg gcaacatcct cttcacccat aaacacagta 1894861 caggaaaagc cgaatttggc tgcaactgtt gcagcggcaa caccatgctg gccggcaccg 1894921 gtttcagcaa tgattttcgt tttgcccatt tttttagcaa gcagcgcttg acctagcgca 1894981 ttattgattt tatgagaacc tgtatggttt aaatcttctc gtttcaaata gattttcgcg 1895041 ccgcctaagt attcagtgac tcgatcagcg tatgttaatg cagtcgggcg tccggaatag 1895101 tcctttaaca gcttataata ctcttcacga aaagcgggat catccttgat ttgtttaaat 1895161 gctgtttgta tttcatctaa cggctgcatg agtgtttccg gaacaaactt tccgccaaaa 1895221 tcaccgtatc tgcctatttc attcggatat ggatacatat cggttcatcc tttcttctaa 1895281 aagcctcatc agattctgat ctttttgtcc gtttttttca attccgctgg caaggtcaat 1895341 tccttctggc tgccatttca ataggcgtgt gatgctatcc ggattcacgc cgccagcgat 1895401 aaagcagcgt ttaccaatag ccgcctgctg atattccggc acacattccc aagaaaatgc 1895461 aacaccagtt ccgcctctag acccttttac agatgaatca atcacaaagc cgtcaacatt 1895521 atctttaaag cgggctattt cttgagttgt gttatcttga tggtgaagcg ccttccatat 1895581 ttcacagcct gtcagcttgc gaagagcagc agcatccgcc ggtttttcat caccgtgaag 1895641 ctgaatgacg tcgagcttca agctcttggc aatacgtgac atcgtctcta ttgattcatt 1895701 aacaaaaaca cctgcaacct gtttttcgac acgaacttgg ttcagccatt ttttcacatc 1895761 ttccggagat acttttcgtt tgctttcagc aaaaataaat cctaggtaat cagcctgtga 1895821 ttccgccgca agctgcaaat cctttagtga ccgaataccg caatatttta atgccggttt 1895881 cttcacaacc tcactcccta aacaaagcat ggattgcttt acgctgagaa gtttgtctca 1895941 tcaatgattc accgataagt acagctcgtg ctccatgttc tttgacaaat gttaaatgtt 1896001 ctaaagaacc gattccgctt tcgctgacaa gcagtgattc tttcggagca agagatgcga 1896061 tttgttctgt ctgcatgata gaggtttcaa aagtttttag gtttcggttg tttatgccga 1896121 gaatatcagg cgtgaatact ttcaatattt gttctagcgt tgttgcatca tgaacctcca 1896181 ctaacacgtc catctccttt tcacctgctt caagatataa ttcatgaagg tgtaagggat 1896241 caagcacttc gccgattaac aatatggcat ccgctccgat tcttcttgat tcctccactt 1896301 gaagagaatc aataataaaa tcttttctga gtacaggtat cgaaacagcg cgctttacgt 1896361 ctgataaata gctgttttcc ccttgaaaaa acggggtgtc tgttaaaacg gaaagcgcat 1896421 ctgctttcgc agtttcatag tcttttgcaa tccgcacagg tacaaaattc tctttaataa 1896481 gcccttttga cggcgacgct ttcttcactt cagcaatcaa cccgataaac cgattcaggc 1896541 ttgccagcgc ctctttaaat gaacgttttt cgaaaggctg ctctaccggc agaaccagtg 1896601 ttttcacttc ttctttcttt tgtttgatga ttttttcaag catagatctc ttcctctttc 1896661 tgctttagtc gttcaagctg cgcggcagcg cctccgcttg taatcgtctc taacgccagc 1896721 tccgttcctt ccttcagtga ggcggtaatt cccgccgtgt aaatcgcagc acccgcatta 1896781 aaagccgtaa tagataaagc ggaactgctg cttttatttt caaaaatatt ctgaatgaga 1896841 taagcgctct ctttcggaga ctgcacctgt aaatcttcaa gtctgccatt tgtgaaaccg 1896901 aaatcttcgg gtgaaacggt atactcccgg cgctctccgt cctttaattc aatcacgtcg 1896961 gtcggtgctg taattgaaag ctcatctaaa ccgtcacggc ttgatacaaa cataacgtgc 1897021 ttcggctgaa acgtctccag tgcgcttgcc atcagtccag ctttttcaac agaatagacc 1897081 ccaatcacct gacgcttcgc ctgtaaagga ttgctgagcg gcccaagcag attaaatacc 1897141 gttctgaaac ctagctcttt tctagtacct gctacatgtt tcatagacga atggtaaagc 1897201 ggcgcaaaaa gaaatcccat gttgtttgtt tcaatgctgc ttttgacctt ttcgggagtg 1897261 gtttgaatag aaacctctag ctcctctaaa acatcagcgc ttccgctttt agaagagaca 1897321 gagcgattgc catgcttagc gattttcgca ccagctgccg aggcaacaat tgccgaggcc 1897381 gttgagatat taaaagtgga aataccgtct ccccctgttc cgcatgtatc aacaatatca 1897441 ggaagtccat cgactgtaag agcgtgtgcc cgcattgcct tcacaaaacc cgcaagctct 1897501 tctggcgtct ccccccgatg agcaagaatt gacaatatcc cccccatttc agaaggagtc 1897561 atttccgctg ccatcatcat attcatcagc gtttcagcct caccggcagt aagggttttt 1897621 ccgtcaacgc acaattgtag aaatctgttc atcagcttta tcctccttgc tatgaaacat 1897681 gtcttctgca atatgaatcg ttttcagcag cgcaccggct ttattacagc tttcttcgta 1897741 ttcggcttcc ggaacagaat cagcaacaat gccagcacct gcctgtatcg atgcaacacc 1897801 gttctttaca ctcatcgtgc gaatcgtaat acaagagtcg atattcccgt caaacccaat 1897861 gtaggcaata caccctccgt atgtctctct cggtgttggc tcgagttctt gcaaaagctg 1897921 catggcacgg attttgggtg cgcctgttaa agtccccgcc gggaaagcag acatcagtgc 1897981 atcgacagga tgaacccctt ttttcaatcg gcctgtaacc accgagataa tgtgcatgac 1898041 atgtgaaaag gaaacaattt ttgtgaactc cggcacagaa acagaaccat actctgctac 1898101 tctgccgata tcgtttcggg caagatcaac gagcatgtaa tgctccgctt tttctttttc 1898161 atccttcatg agctcaacct tcagtctctc atcttcagct ttgtctgcac cgcgttttct 1898221 cgtaccggca atcggatgga tttctaagtg cccgtcttga acgtgtatta accgttccgg 1898281 agagctgccg actatttctc tgtctagcag tttcatataa tacatatacg gcgaaggatt 1898341 gacgatccta agcactcggt ataactcaaa agcatctgct tttatcggca cctcaaattt 1898401 ttgtgataaa acaccctgga agatatcgcc tgcttttata tagcttttga ttttttctac 1898461 atcagccata aaagccgatt tttcataatt agaagatact gtctcaaagc tgggtgtctt 1898521 gtatgaatca gcagaaagaa acagctcttt tatgtttttt tggtccatca ttttttcaat 1898581 gagattttga agctccagat gattttgatg gaatacatcc attttttcgt tttttgtttc 1898641 ctctccagtg agccttgcat attggataaa gtggacgttt ttggtttcat gatcatacgc 1898701 aattaatgtc cggcaaacaa acagcataca cttttccatg tctgtttctt tggtatgcga 1898761 aggaacagaa ggctcaatca gcgggatcat atcatagctt aagtacccga cagctccgcc 1898821 gacaaaagga atgccaagct caggtgtttt gattttgtat gtggtattca tccagttcag 1898881 cacttctttt agttcatttc ctgtgtaaag agatttgctg tcctgatcag cggccgaaaa 1898941 acggccctgc tcttctttaa ttgtgagaaa tggattcagg ccgataaacg aatatctgga 1899001 ccaagtggat gtatcgtcct tgctttcaag aagatacgta atctccctgt caagcttctc 1899061 tatcatttga atgggtgtca gtgtatcgac tgtgaaggtc tccacaatcg gtatcgtgtg 1899121 gtgggacaag ctgtcctcta aaaatgcgga aatgtttgat tggaaattca ttgctctcac 1899181 tccttatggc aaggagaatg agaagatggc atgagaggat aaaatactat ataacaaata 1899241 aacccaaaag aaagacttct tttgggtaga ataaacataa tgtctcagct caactaaact 1899301 cattctctgc taccctattc tctaactcaa ctcattctaa ttgctttata cacactcttg 1899361 tgtatttcta agctgttctt atcgtattac aattcagtat tttttgtcaa tgataaatcg 1899421 ggcctcaata cgacaacttt ttctaaatat acatgtctga tctgatcctg agggacatct 1899481 gtctggaccg tcatcatgac tcttatgcac tttttcagac cgcctgttac gtccatttcc 1899541 tgcatacatg ttaccggtac atactgccat cctgaaagct cgcgaacagc ttttgccggg 1899601 aaaacagcgt gcaaatcagg tgtagccgac agaagcattt gaacaacatc ttccggtttt 1899661 gtatgatttt cttctatgat tttctctaac agctgtttag ttttttgtaa aatttcttct 1899721 tcagtatccc gttcaactgt agttgctccg cgaattccgc gaatcatcat gatgtctcct 1899781 ccaatcgcca tttgttcagc cagctctcaa gttcatttct ggaaaatgta tgatcagcaa 1899841 ctttccctaa ttcgttgagc acaataaact gaatcttccc gccacgggtt ttcttatcat 1899901 tcatcatacg gttcaagaga accgaagttt ccgtctcttt tctgatttga cttggataac 1899961 ccaggctttt tagccagctg accaaacgtt ttctgtccat ttcacagcct acagtctttt 1900021 cgcttatata taaagcaaac tgcattccga gggctacggc atcaccgtga gtgatctgcc 1900081 catatccata ttccgcctca acggcatggc cgagcgtatg cccaaagttt aagtaagctc 1900141 ttatcccctc ttctttttca tcctgctgaa cgacagacgc tttaattgaa atgcctttaa 1900201 aaatcatgtc attcagctga tcattagtga tatcacgcag tgagtggata ttcagcagct 1900261 cctccagaaa cgctctgtca tagataaaag cgtgtttaat cacttctgcc attccggacc 1900321 taagctcttt ttcaggcaga gaacgcagga aatctgtatc atagagcacg gctttcggct 1900381 gataaaacgc accgattaga ttttttccaa gcggatggtt cacggctact tttcctccga 1900441 ctgcgctgtc atgcgccaag agcgtcgtag gcatttggat gaaatcaatg ccgcgcataa 1900501 aagtggcagc cacaaaaccg gcaagatccc ctacaacacc gccaccgaat gcgatgatgc 1900561 atgaggagcg atccatatga aaacgaatcg cttcactctg caattttgtg tacatgtcca 1900621 tggattttgc ctgctctcca ctcggtaccg tcactttttt cacaggccat ttttcttgca 1900681 gcaaatggag catttcatca ccatacaggc ggtccacttc ttcatccgtg acaaacataa 1900741 tccttgttaa aggcctgttt aaagaggtta atagttcgca agcctttttt ctgatacctt 1900801 gtccgataaa aacaggatat gacgaggaag cagtttgaac atgcagtgtc ttcattaaaa 1900861 ttccctcgac agttttctca tattctccac attttctcta atgcggtcaa tttgatctaa 1900921 tccgaattgt tcaacgactg cgttcgcaat ttcccaagcg acagccgctt cagcgactac 1900981 acttgccgca ggaacagcac agctgtctga acgttcaatg ctggcagaaa acggttcttt 1901041 cgtttcaata tcgacacttt tcagcggttt atacaaagtc ggaatcggct tcatgactcc 1901101 gcggacaaca atcggcatcc ctgtcgtcat gccgccttcc agtccgccaa gtctgttagt 1901161 agcacgggtg tatccttttt cctcgtccca aatgatctcg tcatggactt cgcttccatt 1901221 tcgccctgct gcctcaaatc cgatgccgaa ttccacacct ttaaatgcgt taattgacag 1901281 aacagcggca gcaagcttgc tatccagctt gcggtcataa tggacatagc tgcccacgcc 1901341 taccggcatt ccctcgacaa tgacttctac tattccgccg atggaatctc cgtttgcctt 1901401 tgcttcatca atggcagcca tcattttttt gcctgcctct tcatcgtagc atctgacagg 1901461 agactcttcc gttacacgct gcaagtcttc aattgacgta tactctgttt tttcagcttt 1901521 aacagcgcca atttgcaaca cgtggcccgc caccttaatg ccaagctcag aaagaatctt 1901581 tttagctaca gcccctgccg ccactctgac agttgtttcc cttgctgaag aacgctcaag 1901641 cacatttctc atatcacgat gattatattt aattgcaccg tttaagtcag cgtgcccagg 1901701 tctcggtctg gaaatctggc gcttcatttc cttttcttca tcttctgtaa tcggagcggc 1901761 gcccatgatt tttgtccaat gcttccaatc gttattttca actacgagag caattggcga 1901821 accgagtgta cgtgcatggc gcaccccgct cataattttg gcctggtctt tttcgatctg 1901881 catgcggcgg ccgcggccgt gtcctttttg gcgtctggca agctcaaaat tgatatcttc 1901941 ctccgttatg taaagcccgg caggtacacc ctcaataatg gttgtcagtt gggggccgtg 1902001 tgattctccg gctgttaaat atctcatgac ttcttctccc ttcatcgcat taacgctttt 1902061 aagtaagact actataacat atttttcagc aaaaagtcag tctatctttt ttgataaaag 1902121 aatgtatcgg ctgggactag gccaaatttc tcgggattga agatttgctc ggtgctgccg 1902181 acaaaaagaa ctccattctt cttcaagcta tgtgccattt ttaaatacag ctcttccttc 1902241 gcgctttctg taaaataaat aaatacattg cggcacacga ttaagtcaaa gtcttgttca 1902301 taacgatccg ccagcaaatt gtgctttttg aatgtaatat tctttttgat ttccgttttc 1902361 acttcataac ttctatttgc gttttgcgta aaataacgat ctttcacaga tagcggcact 1902421 tcctgtaaag accgctcctg ataaacgcct tttttcgctt tttccaatgc tttttcatca 1902481 atatccgtcg ctaaaatctg atagcccgga agaccttttt gctggtccaa aagcatggca 1902541 agcgtgtatg gctcctcccc cgttgagcag gcggcactcc aaatttttaa aggcctagag 1902601 gtcttgatta acggcagaat tgcagtctca agaacttccc atcttttata attacgataa 1902661 aattctgaaa cattgatcgt cattctgtcc aatgtttcat ttaagagagc ttgatccttt 1902721 tccaatgccg cagcaaagtc cttaaagctt tggaacccct ttttctcata aagtgacgtt 1902781 agccttctct tcatttgtgc ttctttatat agtgttaaat cgactccggt taattgtttc 1902841 catttcgttg taaatacgct gtatgtatcc atctctactc tcccagtctc gctgtctttt 1902901 tgtcctagta tagcttgttt tatcaggaaa ttgtattgtt tcaataaaaa aatcagcttt 1902961 tcagctgatt ttagatcgtt gggaaaggca gaggtctgat gcacactgcc attcaaccct 1903021 ttattcactt taatgtaaac ctttacaaaa cagaacaaaa accggcggcg ttatatgttg 1903081 ccggctctgt tgcttatttt cacaatgatt aatagatcca gcctgccata agctgctgat 1903141 atgatactaa ttcttcattc ttaaagaaaa tgttaatctc gcgttctgca ctttcgagag 1903201 aatcagagcc gtggatgatg ttttttccga caaacatgcc ataatcccca cgaatcgtac 1903261 caggtaaagc ttctttaggg tttgttttcc cgatcagctg tctcgtcact tcaatgacat 1903321 tttcgccttc ccacaccatt gcgaatacag gtcctgaagt aataaactca acgagctctc 1903381 cgaagaaagg cttaccttga tgttcggcgt agtgtttctc agccatttgt tcagtcactc 1903441 tcattaactt ggcgccagct aattgtaagc ccttacgttc gaatctagat aaaatgtccc 1903501 caatgagctg acgttggaca ccgtctggtt tcaccatgat aaaagtcttt tccatcatat 1903561 tctccacccc atcattatgt atgtataggc tttcacactg cacaccgaaa tcgtaacatc 1903621 tttctgataa ttaatcaatc cggggcggag aaatttctta atatctacaa aaattaaaat 1903681 tttcttttac cgatatattt tgcgatggct gcaagagacg agcgtgcgcg ccctcgagga 1903741 agcgtgttta atttctgaaa agctttctgc agatacattt cgcttactgc catagatgct 1903801 tcaattgcat ctgttttttt gatttcttca atgattggtt caagctgttc ctgcgttgtc 1903861 tcactgttaa tcaatttaag ctggtttttt aatgcaggat ttttcagggc atacagcact 1903921 ggcaatgtga cgtttccttg aagcaaatct cctcctacgg gtttacccag ctcttcctca 1903981 gttgaagtaa aatcaagaat atcatcaata atctgataag acatgccgac gtaataccca 1904041 aaccagtaca atgccttatg aatcttctca tcagctccag acgcaatggc accaagctgg 1904101 cagctgaccg cgatcaagag agctgttttt cttttgatac ggcggagata cgttctgaga 1904161 ttttgttcca tgttgtattt gtctttgatc tgctcaattt cccctagaca aacttcaacg 1904221 atcgtctgtg acaaaatcct atgggctttc ggttcgttaa ttctcgtcat catttcaaga 1904281 gatcccgcaa gcatataatc gcctgtgtac atcgcaatac gattgtccca ctttgctttg 1904341 attgtcggtt ttcctcggcg aagctctgca tcatcaatga catcatcatg aaccaaagat 1904401 gccatgtgaa tcatttccag agtgacggcg acatatttaa tcttattaat atcataatcg 1904461 ccaaacatgc cagaaagcag cacgaaaaca ggccgaatac gtttccctcc ggcctgcagc 1904521 aggtgaagac ctgcctcgct taaaagcggg taatcggaac gtacggtttg ttcaagttct 1904581 ctttcgatta catcaatatc gtcatttaaa aaagagtagg ccattttaaa tttcatatca 1904641 ttcacccaaa catctgtgtt ttcatttcca tccgatatgc gtggcagcga ctccgccagt 1904701 aaacgaatga tatttaacat ttttcaggcc cgcctcttca aacaggcctg ccagttcctt 1904761 cattccaggg aaatctctgg ctgattcttg aagccaagaa tattctttat agctcttcgc 1904821 aaacagtttc ccgaaaaacg gcataatata cttaaagtac ataaagtaag cctgtctgaa 1904881 tccgaacatt tccggctggg acgtttccag acataccacc tgcccgcccg gcttcactac 1904941 acgtctcatc tctttcagta cagtcaagta atcagggaca ttgcggagtc cgaagccaat 1905001 ggtgacataa tcaaatgtat catcatcaaa aggaagctcc atcgcatttc cgtgcagcag 1905061 ttcaatttgg ctgaatccgc cgtcttttac tttctgctcg ccgacactca gcatattttc 1905121 actgaaatcc aagcccttga tctcgccgct tttgcctgcc gcttttgcaa gagcgatcgt 1905181 ccagtcagcc gttccgcagc agacatcaag tgcttttgcg ccttccttta cattcatgat 1905241 gcgcatcgtt ttgtcgcgcc attttttatg ctgctgaaaa ctgatgacag agttcatttg 1905301 gtcataattt ttatatattt tttcaaatac tccgtgtacg cgctgttctt ttgagtcctg 1905361 cataatggtt tacccttctt ccactttctg atgataggtt tgatcttggc tgattgtctt 1905421 cagacggttt attaaaatgt tctgaatagg tgaatttaga ggcagaagtg actcaatgct 1905481 gtttttcgct tttttaaaac aatcttctaa tatctcttct tttgtttttc ccagctgtat 1905541 aaaactgccg atcacatcca gaaatgcatc atttccgttc ataagccgct taaatacaaa 1905601 aaaatcactc gacagctttt tccagcgcgg gaggttgaag tgttccgcca cacgatggaa 1905661 taaagctgat tcaacgatgc cgacactttc gaaaaaatcg ttttcgtcct tgaaagaacg 1905721 gtcatacaga cgaattttat gttcgttgat ttctttaatg gctgtagcaa gcgtccgaat 1905781 catgtagata tccttcattt cagatagtaa agagtagtac agcccgctga aataatcgcc 1905841 cgcgagaaca gtcaattggc ggtttttgtt ttcgtctcgt tttatgactc tagctgtcgt 1905901 cacttcatca tgggtatcaa gggcgctttg tacaagcatc gctgttacaa tataattttc 1905961 tctgtcgttg ttttttatgt cggcttcttc aaataaagca tgaaaaagaa gaagcttatc 1906021 ctcatcaatt ttcggcgcag aaatatgctt cgctaaataa ggatgagaca gcttttgttt 1906081 taatttcgtg ttcagattgg ctaaagttcc gtagatgtct tgcaaaaata tcacccttgt 1906141 ccccaaattc acatttattt cttaatctat gtatgagttt tatcttttca ttcgcttacg 1906201 caggtatcat tatagcataa aaaaaagaaa ttggctgtat cctcccgctg tttgcgagca 1906261 tttgctttta acagcgggga cagccagctt attttttttc gcttttcatt tctccgtacg 1906321 cggtttgaat cagtgcctct cctctgactt taatggcaga agtatgctct gtaaactgag 1906381 cgatgatcac ttctcccttg tcgagttttt cggaatggtg aaactttgtg tctgttcctc 1906441 ttgtcaggcc gatcacattc actccgtcct caacggcttt aatgacgaca aaatcacttg 1906501 aatgcttttg gttcatttat agcaccctct atctttatta gtcctggcgt ttaatatgtt 1906561 ccaatacttc tgcacgggca gcggcatcat ctttaaaaac gcctctgact gctgaagtca 1906621 cagttttcgc acccggtttt cttacaccgc gcatcgtcat gcacatgtgt tccgcttcaa 1906681 ccactaccat tacgccatgc ggatcaagcg tttctacgat gctttctgca attgtagaag 1906741 tgatgcgttc ctgaagctgc gggcgctttg caacggcttc aacggcacgt gccagtttgc 1906801 tgagtcctgt gacctttccg cctcgcggga tatatgcaac atgtgctttt ccataaaagg 1906861 gaacaaggtg atgctcacac atagaatgaa acgctatatc ttttacaaga acaagctcct 1906921 catggttttc accgaagata gtctggaaat gttcttttgg atcttcattc aagccggaga 1906981 atacttcggc atacatcttt gcgactcttt tcggagtatc aagaagccct tctctattcg 1907041 ggtcttctcc gatcgcttct aaaatttgac gaacagcttg ttcgatttgc tctttattaa 1907101 cttctttcat gttctatgtc ctccaccaat gaatacattt aatttcgatt ctagcacata 1907161 tgccccgcta aaagcaaagt gaatgccctg tcaggaagcc catgctcttg aaatatgaaa 1907221 agccccttag aaaggggctt ttctgtgaag aaataaagtg tatgtaagct agatgcatac 1907281 acgatctata ttcacaatta ttttccggca actgcgtctt taagcgcttt acctggtttg 1907341 aaagcaggta ctttgcttgc tggaatttcg atttcttcac ctgtttgagg attgcgtcct 1907401 ttacgtgcag aacgttcacg cacctcgaag ttaccaaaac cgatcagttg gattttatca 1907461 ccgtttttaa gtgcatctaa gatcgtatca aaaacagagt caactgcttt tgtagcgtct 1907521 tttttagaca attcgcttgc ttctgcaacc gcattgataa gttctgtttt gttcatgcct 1907581 ttcacctcct cccaaaagga tacattcagt tcgtttatta tcatttcttc acagttcagt 1907641 ctgattctaa acctgtctca gaaaaaaatg agagcaagta agagaaagac aattaaacgg 1907701 ctttttaaga aaaactgcac tctgaggaat gtttgtccaa caaagtgaag aatttctgta 1907761 tgtagagtaa cacatataaa aagccatatc aagcatttta aagcgtcaat cccttgctcg 1907821 tcaaggattt aaggtgattt accgaacgaa tattcctttt tttccttttt tcatcctatt 1907881 ccttgatcct tttccattat taagagcaaa gaaaaaagac ctcccattct ataaagaggt 1907941 ctaccggtat tacaggatga tggcgattaa gccgccagag ccttcgttta tgattctttc 1908001 taatgtttct tttaatttat accgtgcgtt ttcaggcatc aatgacagct ttgcctgaat 1908061 cccttctctc acaattgagc tcagcgacct tccgaagata tcggaattcc agatggagag 1908121 cggatcatcc tcaaagtcct gcattaaata gcgtacaagc tcttcacttt gtttttccgt 1908181 tccgataatc ggggcgaatt cgctttcgac atctactttg atcatatgga tcgacggagc 1908241 gacagctttc agcctcacac cgaatcgcga gccctgcctt ataatttccg gctcatcgag 1908301 actcatatca gctaaagcag gcgctgcaat gccgtatccc gtctgtttga ccatttttaa 1908361 ggcatcagac acttgatcat attctgtttt cgcatgggcg aagtcttgca tgagctcaag 1908421 cagatggtct cttcctctga tttcgacgcc cacaacttct tttaggattt gatcatatag 1908481 atgatcaggc gcgtacaaat caatttctgc caccccttgg cccagctcaa ttccggctaa 1908541 tccggcactt tcaatgaatt caaactcgct gaattggccg acaaccctgt ctacgtcccg 1908601 gagccgttta atatccttaa ccgtttcctt cacggactcc tgatagcttt cacgcaacca 1908661 atggttttct ttcagcacca ttacccagct tgggagattg acattcactt ctagcaccgg 1908721 aaactcgtag agggcctctc tgagcacact cagcacatct gattcccgca tgctctctac 1908781 actcattgcc aataccggga tatcatattt ttcgcttaaa tcctggcgca tggcttccgt 1908841 ttccgggtga tacggcctga ctgagttgat gaccataata aaaggtttgc caacctcttt 1908901 cagctcttca atgactcttt cttcagcctc tatatagtca cttctggcga tatctccaat 1908961 ggtgccgtct gtcgtaatga caactccgat ggtcgagtgt tcttgaatga cttttcgtgt 1909021 gccgatttca gcagcctcat gaaatgggat cggttcttcg taccaaggcg tattgatcat 1909081 ccgcggcccg ttttcatctt catatccttt agcgccgggc actgtgtaac ctacacaatc 1909141 tactaatctt atattcacat cgagtccgtc tgacacatga acagacatcg cctgattcgg 1909201 aacaaattta ggctctgtag tcataatggt tttgccggct gcgctctgcg gcagttcatc 1909261 ctgcgctcgg gcccggtctg cttcgttact gatattcggg agcaccacaa gctccataaa 1909321 ttttttaatg aacgtggatt ttcctgtacg gacagcacct acgactccta agtatatatc 1909381 gcctcctgtt cgttcagcga tatccttgaa aatatcgacc ttttccaagt gatcccctcc 1909441 cggacttcct atccttttca attttattaa gctctttcaa tcaaacacag gacactatat 1909501 gtgtatgacg ttgtcctatt tgaatatgac atctttagaa aatttctcat cctcaatcta 1909561 ttaatataaa aaaacctttc tccctatttg tatgcaaggg agaaaggttc attccttttt 1909621 catatcattt tctaaaaaaa caggttcctg tttgtcattt accgtatatt ttacagaaaa 1909681 cgcggggaca aagggggttt catgccaaat catatcctgg atttcagtcc cgggtttaaa 1909741 cgtttttttg ctttttttga ggcaagaagc cagctcagtc cggtaatcgg catatatttc 1909801 tccgtctccg tcaatcataa gcggcaagga attccctgag attgggcttg tcactgtaag 1909861 agagctgcca tccccaagct tcttctcatc gagtgtaaat aaatcacgag atagcacatc 1909921 cttgtaaggc ggatattgat gctcctgacg atacatttgg atgcgcaatt tcacatcgcg 1909981 aattttttct gccatcttta gatcaattaa tttaacagtc ggatcgttct ctacgtcaac 1910041 aagcacgtat tgatagtctc ccccgctttc aaatgccgta cttggaggtt cagctatgta 1910101 tcttggcgct aaccggttaa agtctatcgg atatttttga tatagcggtg tcgacatatc 1910161 tttggtttga ataggaagca gccctccatt tgccttttga aattcatcaa cagcagattg 1910221 aacctgcttt agctggtctt gataaggaat ggcatgcaca ctgcttttcc gttcatttgg 1910281 atataaacat ccggataaaa acacgactgc cgcaaaaatg attgcgcact tcagtttacc 1910341 catacagcac ttccttttac agctttattc attgacaggg ccgctaaaaa ccacgacaaa 1910401 cacaataatt ccagatatga gcatacacat gtatgcgaat gatgaaatcg caatcttcaa 1910461 aaaacggttt tggcacttaa agcggcttaa atagatggaa gctacagcca gaaacatcag 1910521 acccatggac cctagagcaa accacatttt catcaatgcc agattcaatg acgtgcgcct 1910581 ccccgatatg taagatataa gcgttatatt atattttaat atacagcgcc ggaaaagatc 1910641 aaccagattt tccatccatt gatagaacaa aaaaactgaa gcaaagaggg ggaccttcgc 1910701 ttcagtcaac ttgactatat tcacctgcac gtttaagaaa cactctcttg gacttcgatg 1910761 ctatagtatg cgacttggca tacagatgca tcctctattg cctaaatcgg caaaatgttt 1910821 caggagatcc caagacttgg gtgttcttct gtttttcggg ctttcgttca attaagatat 1910881 gcgattcacc atttgattga cacttttact tcacttgatt ttcaaacgta tttaccaaat 1910941 cctccatctc gtgggttttc cctctcgcca ttaaagattc aacagcggtt tccacttttt 1911001 gtccgttgaa taggacctga tggagagctt ctgtaatcgg cattttaaca tcatatttct 1911061 tcgaaagctg ataagccgct ttcgtcgtgc ggacgccttc gactaccatt cccatctctt 1911121 caagaacatc ttcaagcttg tacccttttc cgagcaaatt gcccgcacgc cagtttctgg 1911181 aatgaacact tgtgcacgtc acaatcagat cgcctactcc tgtcaatcca gagaacgtca 1911241 agggatttcc gcccattttc gttccgagtc tcgcgatttc ggcaagtccg cgtgtaatca 1911301 aagcagcttt ggcattgtca ccgtacccta aaccatctgt aattcctgca gcaagggcaa 1911361 taatattttt taaagcccct ccgatttcaa ctccgataat gtcaggattt gtgtacaccc 1911421 gaaaattgtg attaataaat agatcctgca cctcttctgc tgccctcatg ctctttgaag 1911481 atgcagtaac agttgtgggg tgccgcagcc ctacttcttc cgcatgactc gggccggaaa 1911541 ggacaacgat atcttttctg acatcactcg ggagctcaat ttccataatt tcagaaatgc 1911601 gcagaagtga atctggctca atacccttgc tgacatgaac aaagactgcc tttttcgtta 1911661 taaaagggac agcctgtctc agcacttccc gaattgcttt tgtcgggacc gcaacgataa 1911721 tgacatctgc gtctgaaaca gcctctttca tatctgttgt tcctttaatg gatgtagaca 1911781 gcttaacatt cggcaaataa tctttgtttt catgcaactc attaatttga tgaattaaat 1911841 ctgcacggtg agcccacaca cacacttcat ttccattatc agttagaact aaagccagtg 1911901 ctgttcccca actccccgct ccaagcattg tgactttttt catgtttgat tcacaccttt 1911961 ttattttcta gctcttgcaa atattttgat tggtgtcccc tcaaaaccga acgcgtctct 1912021 gattcggttt tctaaaaacc gttcgtatga aaaatgcatc agttccggat cgtttacaaa 1912081 cacaacgaag cttggcggct ttaccgacac ttgagtcgca tagtaaattt tcaaacgaga 1912141 accgttatga gtcggtgtcg gattcattgc cacagcgtcc atgatgacat catttaagac 1912201 gtttgtttga actcgaagtg aatgattttc actagctttg ataatcgcag gcatcagagt 1912261 atggatccgt tttttcgtta aggcagacat aaataggatt ggcgcataat ccagaaattg 1912321 aaaatgatcg cgaatatttt cttcaaattc tttcatcgtg ctctcatctt tgtcaacagc 1912381 atcccatttg tttacgacga tgacgacggc cttgcccgct tcgtgtgcat aaccggcgat 1912441 acgcttgtcc tgttcaataa tgccttcttc gccatccagc acaaccgcca cgacttctga 1912501 gcggtcaatc gcttttagcg cccgcagtac actatacttc tcagtcgttt catagacttt 1912561 cccttttttt cgcatacctg cagtatcgac aatgacaaac tcctgctggt tgtaagtaaa 1912621 tgacgtatca acagcatctc ttgtcgttcc agccacgttg ctgacaataa cgcgttcttc 1912681 gccgagcatc gcattcacaa gtgaagactt tccgacattt ggacgtccga tcagacagaa 1912741 ttgaataact tcttcattgt atttcgtttc aggaatgttt ttaaaatgct ctgcaacggc 1912801 atccagtaaa tcacccagtc cgagtccgtg tgttcccgaa attggatacg gctcgccaaa 1912861 gcctagcgaa taaaaatcat aaatattcgc tctcatttct gtgttatcca gtttattaac 1912921 cgctaaaaca acaggctttt ttgtgcggta caaaattttc gccacttctt catcagcagc 1912981 tgtcacgcct tcacggccgt tcaccataaa aataatcacg tccgcttcat ccatggcgat 1913041 ttcagcttgc tggcgaatct gcgctaaaaa cggctcatca ccgatatcaa taccgcccgt 1913101 atcaatcaaa ttaaaatcat aattcagcca ttcagccgag ctgtatatcc gatcccttgt 1913161 cacgccaggg gtatcttcta ctattgaaat tctttctccc gcaatccggt taaagattgt 1913221 ggattttcct acatttggtc tcccgacaat ggctacgaca ggtttaccca tagtaccctt 1913281 cctttcaatc cagccgcttt catttttaca taaattttca accggttatt aaaatcattt 1913341 cattcacttt tatgaaaaga aacccttcag aggaagggct taactcattt attatatcag 1913401 tttttactgg gatcacaact attcttaaaa atgtttcacg atcaaataca cgtcatctcc 1913461 gattctgtga gctattccat caaggatcgc ctcaagattt ttagcgaaaa gctccatctc 1913521 cttttggtca ttgcaaaaaa agacaggtgc tccccctgca acccgatttc gatttgtcgt 1913581 gattacagac aaaatcactt tcgtaagaga ttcactcatc ctatcacctt atcctgattc 1913641 ttgataaatt cagtcggcat tctaatcgca ttttccaggg ttggaacatt gctaataatt 1913701 tgaacagccg tttcgggatg gtgaatttgc gggagaacaa atactgccac tctcccatca 1913761 tttaaatccc gttttgcaat tggtgtcaaa gatggctctc ctgaatcccg ataaaccccg 1913821 agcacattgg aaacatcaaa taaaatggcc tgacgctgcc ctaaatttgc tatcgtcgct 1913881 gctgaattaa agtttttcgg cgtcaaaata aagcccatgc catgctttaa aatcagttcc 1913941 tgtttctctg gaagcccgat attcatcata taaatattat caacaaacag tcccggaccg 1914001 tcaaagcgcg gctttatgta ctcgatatct acaatatcct tcaacacact gcccgacata 1914061 aacttcatgg ccagtaaaaa acaaacgaca gccgctatga ctgcagccca gatggataaa 1914121 aacacatacg cagaggttgt caaaagcgct gtaaagatca caatataatt tctgctttca 1914181 aacgcaatgg caatcccctc aatatatgtg cttccccttg agacaagttc atacgaatcc 1914241 atttgcgtca atgtgttccg ctccatgttt cggacatctc taaattgcgt cgctgccaat 1914301 gttaaaaatg tgatggccgt aaattcctcc tgcaaaagcg ccggcataat aattgcacct 1914361 aaaccagccg ctatcaaccc cagtgcgatg tgaatcactt tcccatgaac ataggtcgga 1914421 tactggcggt aatccgtttt cagcatataa agccttgtcg caattccggc aatgacccca 1914481 gcaataatcg gatagatgta atcactcatg acattttggt agctcctttg tttgatcttt 1914541 tgcttttctg accaatctgg cttgcgaggt gttcgtattt agatatgcca aacagcaata 1914601 tcatccccgc agaacacgca ttcagccatt gaaagccgcc gacagccata gccccggcca 1914661 acttctggat cacaaatgaa tacaccagtt cgccttggca catccctagg acaaataaga 1914721 caagctgctt ctcaaaattc ctttcaacag aagctgttaa aagcactatt aatataacag 1914781 cagcccactc aggttttatg atgaaccaaa ccgggtcata taatgcaaaa agataaacaa 1914841 acgcatacgc ggcaacaagc gtcagataga ccatgatgta acgaaaacga tacattccca 1914901 aatacccggc atagacacat ccgcaaacga aaaacatcaa atatgcagca ttcagggaaa 1914961 aatataaagc gatgtcatgt atgcttagaa taatattagt taaaataaag acagagacgg 1915021 caattcgtct tttcgtcttt tcaaaaataa atgttgtcag aacccacaga aaccacattg 1915081 accaatagta ataaaattgt tccattttac ttcctccata ttcccagtat ggagttcaag 1915141 cacatttttt aaacaatcga tctcacatta aggagtatga tcatgggaaa agacagacaa 1915201 gagaaaaaac tcaaagcttc aggcagagtc gaatcagatc gcgaccagtc cattcactat 1915261 gacggagcga caagccttga acaaaacgga agattcaaaa agcgaaaatc ataatacaaa 1915321 aagcccaaac cacatatggt tttgggcttt tatcatttat cgcacactat agcttgatgt 1915381 attgacccct ctctctgtga gccaatgatg ggtttcacct ttgatcacaa ggggcgcctt 1915441 ttgtaaatcg gcaattgttc tggcacccag cacggtcata atcaacttta attcctcaag 1915501 gatcagctga atctcctcaa gcagtccttc ctcaccgctg tcagtcagcg cttttaaaaa 1915561 atgccctgcc attccggtgc aagaggcccc cagcgcaatt gcctttgcca cgtcaagcgc 1915621 atcttgcaga ccgccagagg cgatcatggt gcttgcagga aactcagagc ggatttccgc 1915681 caaacttgca gctgtcgaaa tgccccacga attaaaaaag gagatttgcc gctgtcttcg 1915741 gagattttcg attttcgaga aatttgttcc cccgtaaccg ccaatgtcaa cagctgcagc 1915801 accagcttca tacagctttc ctgctgatgc tttgctcata ccgaagccga cttctttcac 1915861 aatgaccggt acactgaccc ggctgcaaat ttgttcaatg cgtttcaatg cgccgctaaa 1915921 gcttctgtcc ccttcaggca tcacaatttc ctgaatcaca ttgaggtgga tctgcagtgc 1915981 gtttgctcca atcatctcaa cggcttcctt tgcctgagca gccgttgcct cgcttcccag 1916041 gttggcaaaa atcagcccgt ttgggttttc ctttcgaaca atttcatagg aaagacgctc 1916101 tgatggatct tttaatgctg acatttgcga tcccacagca aggggaattc cagcctgaga 1916161 agccgctcgc gcaagcgatt tattaatctc atatgtaagt tttccgccgc cgccagtcat 1916221 tgcattgata aaaatcggcg aactgcttga aagttcgccg atttttgtgg aaatatctac 1916281 ttgttctaat gcaagatcgg gcagactgac gtgaacaaac gtaatatcat caagacctgt 1916341 ttcccgcttc tggccgatgg acaaggcatg attgatgtgt tgtctttttc gttctgctcg 1916401 agtcacgttt atcaccaatt attttagttt attcagctta tctccgatca gatctccaag 1916461 ctggaagcca gtgcttgttt cttccttcgc ttgatattga cggtaatctt cctggtcagc 1916521 tttaggcgtt tcttcaagtt cacgcatgct taatgaaatg cgctcctcat tttcattcac 1916581 atcaagaacc ttcactttta cagtctgtcc ttcttcaagg acttcatgcg gcgtgccgat 1916641 gtgtttattg gaaatttgag aaatatgaac gagaccttca acacctggaa ggatttcaac 1916701 aaaggcaccg aagcttacaa gacgctgtac agttccttca agcacatcgc caggcttcac 1916761 tttttcgccg atttggttcc aaggtccagg cagtgtatct ttgatcgata aagaaatacg 1916821 ttcattatca cggtcaaccg ataacacttt cacttttact tcttgtccct cttcaacaac 1916881 gtcagacggc ttctctacat gagagtggga aagctgtgaa atgtgtacaa gtccgtcgat 1916941 gccgccaata tcaacaaacg cgccaaagtc agtcaggcgc tgtactttgc catcaagtac 1917001 acttccaact tcaagagact gaagaagttc ttgtttttta ttcgcttgtt cactttcaac 1917061 aacagcacgg tgtgaaagga tcacgcggtt tttatcacgg tcaagctcta caacgagcag 1917121 tgacagtgtt tttcctttat agtcagtgaa gtcttcaacg aaatgtgctt caacaagtga 1917181 tgccggaata aaaccgcgaa cgccgatatc aacgacaagg ccgcctttca cgacatcttt 1917241 cacttcagct tcaaacactt cttttgtttc aaattttttc tcaaggtctt cccaagcgcg 1917301 gtctgcatca acagcacgtt tagataaaat caaagcatcg tcttccactt ttgttacttt 1917361 caggtcaagc tcgtcgtcta ctttaacaac atccgatgct ttctctacat gaagacttga 1917421 taattcactg attggaataa taccggattg tttgacattg ataatttcta catctacatg 1917481 tttgtcttct acctttgtca caatcccttt aactacatct ccaacctctg gcacttgaac 1917541 atcaatttga ttcatttcct ctgtcatttg aataacctcc ttggtccaaa cctacacagc 1917601 ttaattaaaa cggtttgaaa gctgaacata taacatgccc gcttttagcc gaatatgtat 1917661 taaagaatca tccaaaaaag ttttttgaat gatcaataaa aagttttatt agtattaact 1917721 tctaataaaa ggacaggttt gtcaagcaat aacattctat cttcgttgaa aaattcaaaa 1917781 aaagtggcat ttgccatcct cagcgggact tttgctccac agcctcgagg attttatcag 1917841 ctacctcttg aatggaaagc gatgtcgtgt cgatttcaag agcgtcttct gctttacgca 1917901 gcggagatac ttcgcgctct gaatcaagct tgtctcttct tgcaatttcc tcaattaatg 1917961 tttcgtagtt gacatcaaag ccttttttca cattttcttc ataacggcgt ttcgctctct 1918021 cttccacaga tgccaaaaga aagattttta cttctgcatt tggcagcaca tgcgtcccga 1918081 tgtcacgacc atccatgacg acgccgcctt tttccccaag ctgctgctgg cgtttcacca 1918141 tttcttctct gacacttctg tgcttggccg caattgaaac ttggttgctg atttcatctg 1918201 ttctgatcgc ctcagttaca tcggtgccgt ttacaaacac tttttgtcca tcttttgttg 1918261 taatcagctc aatgtctgtc cgctttagca gctcagccag tttttcttca tctgtcagat 1918321 caacgttttc ctgtaaagcc gcgtacgtaa tcgcccgata catcgctcct gtatcaatat 1918381 atatgtacga ttttttctca gccacaattt tggcaacggt gcttttcccc gcagctgccg 1918441 ggccgtcgat tgcaatcgat aatttctttt ccataattcc tctccttgct cttttctcct 1918501 ctaaggattg tatcacgaac tttatgaaaa agggtgaaaa attgatgaat aattaatgtt 1918561 tgaaggtttc aatcctattg ttttcctcca ttttatccac cccttcatat tgaatcactt 1918621 ttgatacgta tggttcaata tgctgatagt gaaaaagaaa ttggacacca agtaaaatga 1918681 tggcctgaat gaacaataat ttgatcagca gccgttcaaa tgttttcatt ggagcacctc 1918741 cattacaaat agtatggaag tgtttgccga tgtttattcc attcgggcct ttcttctctt 1918801 atttaactgg cgcctgatgc agtattgaag caaagcctgc tggtcacctg ctgcaatttc 1918861 tgaatactct aaagtcattt ttcgtttttc tgacttgggg tcattaaaga ttcgtctgac 1918921 aactgcttct gtttctattt gacgtgtgtg ctcctcttca ggaagacgga tgatcaggcg 1918981 caatgattcc cccgattgaa aagaaaggcc atcagctaaa accacggcga tgccgcctgc 1919041 actgatgtta taggatagtg tgcggatctc ttcttcattt cccggctgaa tttgcacatc 1919101 taataccgca tcagttctta catattggcg gcgctggatt cttttcattt tttcacgggg 1919161 aggcatttca agacagatca tttgaagttt gtccttcact ttacctttta tacggcttat 1919221 aaagcgataa ggaacttcgt cttttcccac aaactctacc gttacttcca tatcgttatg 1919281 taaaatcaca gttcgccctg taactacatc aacaggatac gcgatcaaaa gttcattgtt 1919341 ttcgatgctg accgccttgc tttttgcctt tttcaattca ttttcttcta tatattctaa 1919401 aagtacattt tctccaatct ctatcattga cttcactctt tcgcattcaa tatactcacg 1919461 tttttattaa agcacgtaat gaaaaaaagg aaaagacatt tagtcctttc ctcctgtttt 1919521 tataggtctt tatatatagg ttctgcattt tttagttttt caaccttttc ttccgatccg 1919581 tctttggcat tgatatacat tctgaatgtg tcattttcaa ttgtcccaag catttcgtag 1919641 cataacactt cttgacctag ttcatttgta atcaaagcga gccttgtttc tctcacttgt 1919701 acatttttat ttaatttaga ctttgcctct gcttcagtaa ttgcaggctt aggtatggtt 1919761 ctttttctgt gagatgtgag gaagtctctt gctgaaaagc cgacaacctc accgtcatcc 1919821 aaggccactt tcatacgaat tgcctcgggg tacatccgga ctttattttc aacaggaaca 1919881 tatgaaaata caccgatttt atcatattgg gcactttcat caatttccaa atcatctgtt 1919941 tcaaatccgt ttttctttaa aaatgcaagc gctcggttcg atccgtcatt taaactgatt 1920001 ttctgatctt tcacttctct gttttggatc aagtataccg gatgcccgcc cttcttcgta 1920061 atatccatat aaatcactgc tttatggtct gggtctttca tgctgatgct atatacatcg 1920121 cgatttgttt tttttccgct ctttaccact ttaattgaat aattgtcatc tggggcaaag 1920181 cgctcagcaa tttgttttgc ttcctgttcg gaaatttgtt ttcccttcag atggctgaag 1920241 cctttctctt cttttttcgt actggtgaaa ctcgggccaa gatcagtgcc agtggagaat 1920301 gcaccaacat ttttttcgac tgttttaaag ctgttgataa tcgtattatc actttgtttt 1920361 tcgtcagaag ccagagccat ttctacgtcc atccagcgaa ggtttttgct catgacaagg 1920421 tgctgaacat gacgcaattc attttgtata tcttcggact gctgatatag cttatttagt 1920481 gatgtatact cgtttttatc aagcggcttt tggtccaaat ctctgactga cgttttatag 1920541 ctgaaatcgc cgatctttga taatagctct tcagttttat taaacggcat taatgtaagc 1920601 ggcagctgac tgacgctgtt atgagcttct gatgtaatcc tccacacatc gatcaatgca 1920661 ggcgacagtg atttttggct gttcatggca agtgttgttc cgattttatc atgaagctga 1920721 tccacctgat aggtaagctc atgaaacgcc cgctgatagt tattttcagc atgaagaaga 1920781 actgcgtctt tttcctggtg ttctttgtat ccccagtagc ctgtaccgac tattgcaata 1920841 ccaagcacgg cgattaaaat tcctctgatc atttatcaca cctcttttta tgctttctca 1920901 tatctgctac tcacagaaaa tgtgtttacc gattctttta atctgcggac gcccccaaat 1920961 ccacggactt gtagccgtat ccggattaaa gtagtaaagt gcttcctctg atgggtccca 1921021 gccattgatg gcatccagca ctgcttctcg tgccgtttca ttcggctgca tgtaaatttg 1921081 tccgtcggct actgctgtga aggcaagcgg ctcaaaaata acccccgcta ctgaatttgg 1921141 aaataacggg ctgttcaaac ggtttaaaat gactgctgca atagcaacct gcccctcgta 1921201 cggctcgccc cgggcttcgc cataaaccgc ttgagcaagc agcctgatat cgttgttgga 1921261 aaatccacca ggcatgttcg ctgctaccgc atcctgtttt cttgcttttg ctggtgtatt 1921321 gttttgctgt ttattcgcat tcgctttagg cttctgcgtt gttttttccg caggctgttt 1921381 ctgccgtgct tctgcttgtt gtcttgcctt ttgtgttgct gcttttgatg gtttcgtctg 1921441 atactttagc ggaatttttc cgtaatgcgt gaatgtattc cctttattga gctgttccat 1921501 gacatattca cgatagtatt ttgatttaca tattaaggtt tgctttgttt tagctcctac 1921561 aaggccgtca acctctttta acccgaattg atcctgaaaa tttcgaactg cccagtacgt 1921621 cccccatcca taaaccccgt caatttttcc gttataatat ccgttgtatt gaagacgcgc 1921681 ctgaagctcg accacatcat cccctgttgc ccctctttga atgacctgat tcgaaaaggc 1921741 agagatcgtt tcagtattaa taaacgtcgt tattgtaaag gaaaaaagga tgagacatgc 1921801 cataatcgat cctttggact tcatcttttc aagcctccta ctgcaaattt ttaagtgtaa 1921861 tcgtattttc tgtaacgagg ttatttttat acactctttc cttgttatcc ctcagaacat 1921921 aaaaactgca cacaaaaaag ccgcacggtt gctgtgcggc ttctatactt gcatcatatt 1921981 aacggaacgg gcttttttcg ctttacgcaa accaaaccac cataaaaata ccataaatgg 1922041 aagcatataa taaatccaat tgctaagcgc tgttaggata aaatcatatg atccatgcaa 1922101 aagggatggg acaactaaag aaagagtaag ccactttaca cgcgccttat cagcggaaaa 1922161 acgggctttt ccaaggtaaa atcccattat aacgccaatc aaggcatggc atgaaacagg 1922221 cagcagcgcc ctgacaaacg catgctccac gccgtggcca attaaataaa gaatattttc 1922281 gagggttgca aaaccgagtg atacacttgc accgtacaca atcccgtcat aatgctcatc 1922341 aaagtgggcg tgcgggtaaa cactgatcat cagtataaac cattttaatg attcctccaa 1922401 aaaccccgaa gataaaaaag aaacgaaaaa gcttccgcct cctacattct ctttttcaag 1922461 tacatactgg ataaacatga tgggaaatac aagaacaacc ccgagaaaaa acgaccgtag 1922521 caccatatgt acaggttcat tatcatactg atcttttaaa taaaaataac ttaataacgc 1922581 gatgccgggg gcaattcctg cagagatgat tgcaaacatc aggcaacctc tttcctttat 1922641 attcctacat ctatcctacc atgttgttta aaattttaca tctgtctgca cttaaaaaaa 1922701 caaaaagagc atacgaatgc atcatatgct cctcatcttt aatggttttc tcttttggcg 1922761 atttccgctg cgatatgccc cccgtgaaac ctgccgtttt caataaatat ttcatttgca 1922821 ttgtttcccg cagcaataac accggcaata aagacacctt caacgttcgt ttccatcgtt 1922881 tcttcgttga aaaatggacg ccctgtttct ttatcaattt caacaccaat tttttcaaga 1922941 aattgatgat cgggatgata gcctgtcatg gcaaatacaa aatcattttt aatggtaatg 1923001 agttctttct ctccggagcg aaacacaact tcattctcgg tgattttttc gacacaagct 1923061 ccaaattcca tacggattgt accgtttctg acgagagctt caaattccgg cagaatccac 1923121 ggcttaatgc tcggagaata ctcattgccc ctatataaaa ctgtgacacg cgccccagat 1923181 ttcacgagtt caagggcggc gtccacgctt gaatttttcc cgccgatgac aacaacatct 1923241 ttatcaaaat acgggtggcc ttctttaaaa taatgaaata ctttcggcaa atcctcaccg 1923301 ggtacgccca tatagtttgg atgatcataa tagcctgtgg cgatgataca atatggcgtc 1923361 gtgtaggtct cttttgacgt ctcaataacg aatgtgttat tttgcgtttt cgtcacttta 1923421 cgcaccattt caaacgcatt aacacggatg tttttccgtt taacgacttc ccggtaatac 1923481 gataaagcct gaattctgac aggcttcctg ttctctgtaa taaatgccac atctccgatt 1923541 tcgagctttt cacttgaact gaaaaaggtt tgatgcgtcg ggtaattgta aatactgtta 1923601 acgacattgc ctttttcgat gacgagggca tcaatgccaa tttgttttag gtgaatggca 1923661 gcagatagtc cacaaggtcc tccgcctata ataattgctt tttcttgaat catttctgtc 1923721 aactcctgcg attggcattt cacttcatat tttctatttc cgaataaaaa aatctcctat 1923781 tttatcatag gagatttttt atttttatgc aaatcatcaa cttatatcca gcctctaaaa 1923841 cgcgaagctt cagccatttt gcgaacgccg accatatatg cagcgagcct catgtcaatt 1923901 cttcggttgt tagccatttc gtaaatattg ttaaatgatt tgaccatcat tttttctaat 1923961 ttttcttcta cctcttcttc actccagtag aagccttggt tattctgaac ccattcaaaa 1924021 taagaaactg ttacgccacc ggcacttgcc agcacgtctg gtacaagcag aatgtcccgg 1924081 tctgaaagaa tttttgttcc ttcaagcgtt gttggtccgt tcgctgcttc aacgacaatt 1924141 ttagcccgga tattatgggc attttcttct gtaatttgat tttcaatcgc agcaggaacg 1924201 agaatatcac aatccagctc cagcagctct tggttggtaa tggtatcgtt gaaaagcttt 1924261 gttacggtac cgaagctgtc gcgtcggtcg agtaaataat cgatatcaag gccttccgga 1924321 tcataaagtc cgccatacgc atctgagatg ccgacaactt ttgcccccgc atcatgcata 1924381 aattttgcca aatagcttcc cgcgtttccg aagccttgga caacgacacg cgcaccttta 1924441 atatcgatgc ctctcttctt agccgcttct ttaatacaga tggtaacacc ttttgctgtc 1924501 gcagattctc tcccgtgaga tccgccaagc acaagcggtt tgcctgtaat aaatccaggc 1924561 gaattaaatt catcaattct tgaatactca tccatcatcc aagccatgat ttgtgagttt 1924621 gtaaatacat ccggtgccgg cacgtctttt gtcgggccga caatttggct gatcgctctg 1924681 acataccctc tgctcagacg ctccagctct ctaaacgaca tatcccttgg atcacaaaca 1924741 attccgcctt taccaccgcc atatggaaga tcaattatgc cgcattttaa actcatccaa 1924801 attgaaagcg ccttcaccgc cttcacctct ttttctgtta cgttcgggtg aaaacgtatc 1924861 ccgcctttcg ttggaccgac agagtcattg tgctgcgcac gatatcctgt gaaaatcttt 1924921 actgaaccgt cgtccatacg aacaggtatt tttaccgtta ataatctcat cggctctttt 1924981 aacaattcgt atacctcttc gggatatccc aatttttcca gagccttatg tattacggtt 1925041 tgggttgatt ttaatacatc aagtttgtcc tcttctgtat gaccggtgtt tcgatcggct 1925101 gccatttgag ttaacctcct agaatcttct gtttctcaca tgctcccttt cagagaatag 1925161 tatacacctt catatgatct gtgcatagaa taaacgttat gtttttccat gttttttaac 1925221 gaaaaaaaac tgctgaaatc agcagttttc cgttgcattc ttatgaaaaa tgagtttgta 1925281 tcgtttctac ggcattaccg tccataatga gcttaccata ctcttgcagg cgataaatcg 1925341 ttaaagttgt cggattgccg tattcagcca gaaccgccac aaccccttca gccgtatgtg 1925401 accctagatc ttcaaggctt aaaaagtact gcccgtcata gtggtagaca gttccccctg 1925461 tgataccgat tcgctgtaag ctttctgaaa gctgaatgat atcttcaaag gaatggaatt 1925521 gatatatgat gtccgcgctt tcatcaagct tgacttgcat ttcgatgtaa tcatcatcat 1925581 actcatcgtc ttctgaatcg gcgtcttggt tctttgttac aatcacgacc atcccttgtg 1925641 cttggagaga atacacttcc actgcaatcg gtccattcgc ttcaaagccg agctctgtat 1925701 ttgcttcatt catcatatct ttaaataact ggtggacttt aaatgagtcc ttccagaggt 1925761 cttcttttgt caatccccgg tctgtcaaat catcgagggt taaaaagatt ttgatcttat 1925821 tataattcag acgctcaagc cgcataacgt tccctcctgc ctctacttgc acacaaatca 1925881 tataacacat tatatgagat gatgagtcat aggttcttaa ttgttatcag tttacactga 1925941 gttcactagt aagacaagca caatgcagtt tttattgcca tacggatttt tgctttttag 1926001 aagttattct ggcccgcaaa gagtcacaat gtgagtttca ggctcagcac ctaaacgaag 1926061 aggcactttt gtcgtgccgt agccgttgct gatcagatat gccgcgtttt taacaatacc 1926121 tgttttcccc agttcataag gaccgaattt tccaaacctg atctggcctc catgggtatg 1926181 tccgctgagt atcacatcaa taccgtcatc ttcattgatt tgttcatgaa tctccggatt 1926241 atggcaaacc agaatattca gctggctttc atcaagttct ttgatggctt cctcataatg 1926301 atccatctcc atcctgatat catcaacccc cgcaatcgca atcgtatgcc cattgtatga 1926361 aaacgggact gactcatttc tcagagtgat gacgccgtgc gctttaaata tggaatacag 1926421 cttatgctgc ctgacttcat aatcattatt cccccacaca aacacgatag ggaccccgaa 1926481 atgtacgagc cttttgatgt tttcctcgat tctcgcactg ggcaccccgc cctcagctaa 1926541 atcaccgccg attataacca agtggggggc atggcttcgc gctttttcta aaaggtcttg 1926601 atcgatgaga cgtttgtgaa tgtctgaaat aaaaaagatt gtcagaggcg gcttgccctt 1926661 catctttgat aaaggaaacg tatgtgtctt caaatgattg ccttttgctg ttgcatacat 1926721 ttttgccgtc attgccgctg ccgcaacagt tagtacaccg gcaattttca ctgatagctt 1926781 cataaaaaac tctccattct ttttagaact tatcaataag acggacaata aaaaaagacg 1926841 tttctatcgt ttgagaaaac gccccatttt atttactttc aaaatataga ttaatgtcat 1926901 atttgtgctt catcatatga aaaacagact ctctcgcctt ccatttatcg ggctgcggcc 1926961 agagatcagt gcttttctga ataatttcac atctcagttt atggaaatca gtctcggatt 1927021 tttcttcctt tttcttgaaa taatatgaag tgcagtaggc aaaagcggtt gccagcatcc 1927081 aaaataaata aaaggtatgg ctaagtattt cttgaagtat aagctgaggc tccgggcttt 1927141 tgatcatgat cataacacat aataagccta ggcagataag tgaagcccat cgccatctgc 1927201 ggcattgtgc tgcataattt tcgaattttt gttttcgttt taccagcgct tggagcatct 1927261 gtttggtcgg cgcgtctgta aactgatcca gctgattcca taaggattcc atacgcttca 1927321 caccttgtcc attttcattg ctacaatata tgaacgtaaa ataaaaataa taccctattc 1927381 atccattaaa gggatgtcca aaacttgtcc ggtgtaaaca tcatttccat tcagatgatt 1927441 atatgctcga attttttctt ctcctgtccg gcttttataa tacttcatgg aaatgcggta 1927501 tagcgtttct ttcttttgga cggtgtgctt gacaacgcga ttcggcacat tttgaactgg 1927561 ctcagctggc tgttcttgct gttgtactgt tgattgggaa gaggaagcag ccgcggcggt 1927621 tgcttcctcc ttatttggcg agtcttcttt ttccgctaca gcagtctgtt tcttatcagc 1927681 agctgtttgc tcttttggct tggaatcttc tggctctttt tttgactcct tctgcagtgc 1927741 ggtttcttta gtgtctgcgg tatcgttttt atcctctgat ttcgggacaa cctcatattt 1927801 gctttggctg ctgtcaataa aaacatcttc ataatcgtca tgattatccg ggtggctctt 1927861 tagataaaat aaggtgacta aaacgataac cggcacaaat acaaatatta ctgcgagtac 1927921 tgtgaataat ggcgtttttg ttttgccttg cttttttttc tgttctcttt gattttttac 1927981 agattgtctt gtcggaaggc tttctccatc atcgacataa tcgtccgcca atgcggcgtt 1928041 ttgatcttca taaagattct gggcttttct tctctctact ctcgacatgt tcgtcatgtt 1928101 tatccctcct cacatgttca aaacgaatct gacaggcaaa cacggcatca atgataaaat 1928161 gcgccgtcat cggaacaaat aagttgccgg tccattcata catcagaccg agcaaaaagc 1928221 tgattgctgt caccataata aataacagcc attttgacaa ataccgaaag tgcagagcgg 1928281 caaatataag gctggccgtc cataaaccga tatgagtctg cagcactcct ctgaataaca 1928341 tttcttccgc gaaagcaatc agaagcgtta aaaatataat atgagggatt gacctcttac 1928401 tgaatatttt tttattgatt ccgccgtcat catataaatg agacggaaac catttcatta 1928461 ctgccatatc ggctaaaata acaataacag ctatagaaac accataccag atgattcgca 1928521 tatcgcgaat gtcccagagc tttaatacgt cccgtacatc ctcaaaaaag aacagtcctg 1928581 ctgcagcagc ggcaaagatg atgagtagct gcgtcaaata taactgcttc agcatatcat 1928641 ggtcagtcat atgctgaata taatcttttt gctgtttcag ttcagctcac ctacagtctg 1928701 caagctgaat atccggtgca attccgaact ccagctgtct aatggcgcca ttttactccg 1928761 ttcccctttt tgttcataca aggataaatc aaaaccgcaa tgtgaacagc acgggaggtt 1928821 tccgtcatca ggctcgtatg attcatcaaa gtaggttaac agtgcctgcc ttaaacagcc 1928881 gtcacgctga agcaaaaatg atacacggtg cattttttcc agcttcagct ccatgcgata 1928941 tgaaatttct ttcttcatca gttcaactga tgtttttccc tgcataaaga gatgaatcat 1929001 catacgggcc tgtgtctctc cgacgccata ctgaagtaat acgtcacgca gccttctctc 1929061 atcccgctcc tccgtcttct ctagcacacg gattacgtcg gcgatttctt cagctgtgac 1929121 actctccatc tggataattt gttcctgcaa ttcaaaatcc cctggcgccc gcagcaaaat 1929181 gctgacactc ggctttccgt cgcgtcccgc tctgccgatt tcctgcataa aagcttctgc 1929241 cgtctgcggg agatgaaaat gaatcacata tctgatatca ggtttatcga cacccattcc 1929301 aaacgcattc gtacaacata tcacatcaag ctggttatga ataaactgct gctgaattaa 1929361 aatcctgtcc cctgactcca aaccgccatg gtaaaagtcg gctctgctgc tcgttttgct 1929421 tttaatttca cccgctaatt ccttagccca tttccgtgtt ggacaataaa caattcccgg 1929481 accttgcagg ttttcaacca gctgaatgac cctatctatt ttttcggcag tatccgccgc 1929541 attttcaacc ctcagtgcga tgtttgggcg gttgactgag ttgagatggc gtacagcatg 1929601 ctgcagctcc agcaggttca tgacatcttg cagcgtttcc tttgtagccg tggcggtcaa 1929661 tgccagaacg ggtgggtgtc caagtttttt tctcagctgt ccgagctttg aataatcagg 1929721 cctgaagtcg tgtccccatt cagaaataca atgcgcttcg tcaataacaa ataggctaat 1929781 cggaacgctt ttcaattttt ccaatacata tggagactgt aaagcttcag gagacaagta 1929841 caaaaattta tatcgatgaa tatgttctaa aacaaattgt ctttcctgcc tgttaagcat 1929901 gctgttcaaa gctgcagcac gcttttcccc ccgggctttg agctgctgca cctgatcctc 1929961 cattaaagaa agcagtggag aaacgattaa taccatgcca tcaagcatat aaccaggcag 1930021 ctggtagcaa agcgatttcc ctcccccagt cgggagcatt gcaatggtat ccttcccgct 1930081 gagtatgctt tcaataatgt cctgctgccc ttttttaaag gaagtaaaac caaaaaactg 1930141 atataacgtt tgctgtaatt tagtcatatt gctgcacctg ctttgtcaat gccagtctga 1930201 tttgaaagta gctgaaccgc tgttccagcc cgtcgcgaat ttgtttgatt ttattcgtcc 1930261 gcatccgttt ggcaaactct gcgatttgaa gctggtcttc tgctgataca tagtcattaa 1930321 tcataaacgc aggctcatgg agagaaatct cgacaatgtg gtcttcaatc gtcgctgttt 1930381 tcagctttct gatttcagca attcgctgta tcggaaaccc ttgtttgacc atctgccatg 1930441 ttttcctcgt cgactctgtc agggcattat ctaagtgcac atcagaaagg agatccttta 1930501 acaaagcatc ttcacactcc ggaagagaat gaataaaata atgtaccgaa gcccaaaaca 1930561 tgatatagac ataccattcg tcttctttca gcgtatcagc aagctgcctg ctcgtataac 1930621 cgatccgatg gtgcgaggtt aaggagtaga caaaaatttg cgctgctttg ttttcaatct 1930681 ttttcaaatg cgcctcaagc atggcaaaaa ggctttttgc catctctata tgatccgtat 1930741 gccgggacag gtatttcttt acccagtgaa gtgtcttatg atcctttgtg acagggatat 1930801 actgcctgct cccttgctgt ttatgggata ggacctgcac aagcagcgaa agccttttcc 1930861 aaagcacgcc ggcagcctgc tgataatgag cgccgtgaca atgaacgggc caaggccgct 1930921 cgctaagggc atgtctcaaa actgctgcgc cgctggctgt cactttgtat gtatctgatt 1930981 cagacattgg cgcgagatat gaatgctttt caagcttgtc aagcgacgca gaaatatcgc 1931041 ttctcgaaca ttttgccgcc attccaaagt attttgcagt ctgaaataag ccggcatctt 1931101 gaatggtctg tgacgatctc ttgcctttga ataggtgaaa aacagcgctt cccgaccgtt 1931161 ccccgtttat tttgcaaaga caatcgagaa ccataatatc gaagtaattt aatgacaacc 1931221 tatccaccta cattcttcct gacaaaaatc gttgatttgc tctttttatt ttaacagatt 1931281 tcaaacagaa atcgacgttt aaagtcatca ttaaggggga tgttatgtag ataacccctt 1931341 atgtgataag cattctcaat catttttctg ttgaaatgtg gcagcaacat cattacaata 1931401 agtaagagga ataggtgtta aattgattaa atataaagat tgatccattt gttccaccaa 1931461 gaacaatctg ggaggtttta ttcatggcaa agtacacaat cgtagacaaa gatacatgta 1931521 ttgcatgcgg cgcttgcgga gctgctgcac cagacattta cgattacgat gatgaaggca 1931581 tcgcgttcgt aacgcttgat gaaaacaaag gtgttgtcga agttcctgag gtactggaag 1931641 aagatatgat tgacgcattt gaaggatgcc ctactgattc catcaaagtg gcggatgagc 1931701 catttgaagg cgacccgctt aaatttgaat agaagtaact aaaaaaagct cccgaacggg 1931761 agctttttta tttaatggat atgtgcactt cgctgctgct caatccatgg cttaagcttg 1931821 ataaaaatta gtgagaatac aaccgtaatt acaatacctt ttatcatgtt aaacggcagg 1931881 atacctgcga cgactgctgt ttttagcgcg ctgtcggata atgccggtga atgtaaaaac 1931941 cacgtgtatg ccggaagaat cagaacataa tttaaaatac tcattaaaat ggtcatcgct 1932001 gcagttccca aaagcaggct gacagccaag ccctttgctg agttgagttt tttaaataag 1932061 aaagcagtcg gtaatataaa gagtgttcct gcaataaaat tcgcaacttg ccctacagga 1932121 actccggcca tgcttccctg aatgatatac tgaagaacat tttttatcgc ttctacggca 1932181 atacccgcca aaggtccgta aatcagaatg gcaataattg cgggaacgtc gctaaaatcg 1932241 atttttaaat aatccggaag acccggaaac gggaaattta acagcatcaa aacaaatgca 1932301 atgctgctca gcatgctgac cacaactaat ttttttactt tcacttcatt ctctcctttt 1932361 cgatcacatc ttactcgaaa acggaaaggt tcttttccag ccaataaaaa aaccgcttca 1932421 tatataaaag cggggtttcg aaaattaggc taggcaaaga aacgtttgaa aaattcaatt 1932481 tcaaaacgct tatgaacctc catcttctcc catccagact gtactgtcgg ctccggaatc 1932541 tcaccgaatc ctgctgtaaa gacagctcgc gggcttagag ccattggctc atcaccgccg 1932601 gtagggaatt tcaccctgcc ccgaagattg atcatatgaa atttaattac attataaacg 1932661 ataactggtt ggctgtatag agaattgctt caaattaaat atattacctg caagctgtca 1932721 gatcattgat ttattaggct ttacttttat cctttactgc gtcaatacac gttgacactc 1932781 ttttgagaat atgttaaatt atcagatatt tagtttgtca atttaggagg aaatctaacg 1932841 atgtttcgag tattggtctc agacaaaatg agcaacgacg gtttacagcc acttattgaa 1932901 tcagacttta ttgaaatcgt tcaaaaaaac gtagcagatg cagaagatga attacatact 1932961 tttgatgctc ttttggtgcg aagcgcgaca aaagtaacag aagacctttt caacaaaatg 1933021 acttctttaa aaattgtcgg aagagccggt gtcggtgtcg ataatatcga tattgatgag 1933081 gctacgaaac acggggtaat cgtgatcaat gctccgaacg gcaacaccat ttcgacagct 1933141 gagcatacat ttgcaatgat ctcttcttta atgagacaca ttccgcaggc taatatctca 1933201 gtgaaatcca gagagtggaa ccgcacagct tatgtcggtt cagagcttta tggaaaaacg 1933261 cttggtattg taggattagg ccgaatcgga agtgaaattg cacagcgtgc gagagcgttc 1933321 ggtatgactg tgcacgtttt tgatcctttc ttaacggaag aaagagcgaa aaaaatcggc 1933381 gtaaacagcc gtacatttga agaagtgctt gaaagtgcgg atatcattac cgttcacacg 1933441 cctttaacaa aagaaacaaa aggcttattg aataaagaaa cgattgcaaa aacgaaaaaa 1933501 ggcgttcgct taattaactg tgcgcgaggc ggaattatcg atgaagcagc acttctcgaa 1933561 gctttggaaa acgggcatgt tgcgggagca gcgcttgacg ttttcgaagt cgaaccgcca 1933621 gttgacaaca aacttgttga tcatccatta gtcattgcca ctcctcactt gggagcatca 1933681 acgaaagaag cacagctcaa tgtcgccgcc caagtgtcag aagaagttct gcagttcgca 1933741 aaaggcctgc ctgtcatgtc agctatcaac ctgcctgcca tgacaaaaga tgaatttgct 1933801 aaaattaagc cttaccatca aattgcagga aaaattggca gccttgtatc acagtgcatg 1933861 aaagaaccag tacaggatgt tgccattcaa tatgaaggca caattgctaa acttgaaaca 1933921 tcgttcatta caaaagccct tctgtcaggc tttttaaaac cgcgcgtaga ctctactgtt 1933981 aatgaggtca atgccggggg tgtcgcaaaa gaacgcggca ttagcttcag tgaaaaaatt 1934041 tcctcttctg aatctggata cgataactgc atcagcgtaa aagtgacagg agaccgcagc 1934101 acctttactg taacggctac gtatattcct catttcggag aacgaattgt cgagatcaat 1934161 ggatttaata ttgattttta tccgactggt cacttggtgt atatccagca tcaagataca 1934221 acaggtgtca tcggccgagt aggacgtatt ctcggagata atgatattaa cattgcaact 1934281 atgcaggttg gccgtaagga aaaaggcgga gaagccatca tgatgctttc ctttgacaga 1934341 catctggaag ataaaattgt gaaagaacta acaaatgtcc ctgatattgt gtctgtgaag 1934401 ctcattgatc tgccataatt aaaaaaactc aagctatata gcttgagttt ttttattgtt 1934461 ctatccccgt gtgtttttat gcaaaatatc taagacactc cttagctcag aaacaggaat 1934521 ttggcctggt gcggacgcct cttctccagc tccaaaagta caagccgatc caaaaacctc 1934581 accgctcagc ctgctgatga gccctgttgc agccattgac attgtaataa tggggcggtc 1934641 tgcatatatt gttttcattg tatacgtcgc atcaagcagt gttaggagat ctccagtatc 1934701 attcggcatg acagccattt ttggaatatg cgcgcctaag tcctgcattt ttcgaagtct 1934761 ggaaataatt tcatctttta caggtgtttt ttcaaagtcg tgatttgaca tcaccacata 1934821 gacgttgttt tcttccgcca gcgatactaa cgcttttaca tttgcatctc ctgaaaataa 1934881 ttcgatgtct atcagatcga tgtcttttgt ttggattgcc gattccagca aagcaagata 1934941 ggagctttcg tccatctcca tgctcccgcc ctctttgtgg gttctgaatg taaatagaaa 1935001 tagcttgtct tctaaagatt tacgaagctt agaaatgagc tttgtgaccg cttctctgtc 1935061 attcgctttt tcaaatacgt cgactctcca ttcaacaatg tccggattca gtaattttac 1935121 tgcctctgct tcattcagaa tttgtttttc cgtctttccc atcagcggaa tgatgatttt 1935181 cggcatccct tccccgatgg aaactccttt aatcgttaac acgttcactc gtctcaaatc 1935241 ctttcaatct ttaccttgtt ttattataca cgtacaactt ttttttgaaa atttctatta 1935301 tatgaatagc aactaaaaaa gagccttaaa gggctctttt tagtttaagg aaatcggatt 1935361 tggagcagct ggcaccggaa ttgcatctga tatgtcatat ttgccgattt ttttcgttct 1935421 ggtttccgta aaggtcactt ctgtgaagcc aaactctttt gcagtcaaaa gtagtccctc 1935481 aatcattaaa ataccggcaa tagaatcatc aacttctgac tcctttgaaa agcggatata 1935541 taagtgtttc tgtttcttcg ttacagattg gacagcaccc gcttgaataa gaggtgtcgt 1935601 atcttcttgg ctgctcgatt ccatttcctt aatcgcttct tttactgtat caaaagaatg 1935661 atttgacgga acgagaaagt cttgtccttg tttattttgg tacaagtagt aggatcgttt 1935721 tgactgtttg ggaatcgaaa tttccgtaaa agtgccatat gagccaatcc gaaccccagt 1935781 ctcattttga tccgataaaa atttgacttt ttcataagga ctccatttta aggattcttt 1935841 aagcaatttt tttaacagtg tatcatcttt tatagaaaat gccgtagctg gctgatggac 1935901 tcgtatactt aattccttct gctttggttt ttcctttatt tctacttcat ctatgaaggt 1935961 tggaattgta atggcatgat caaggatgcc caattcacta ctttcaaaca gcatatcctg 1936021 gatcgtttgg tctgcatttg ttttttgaat gctgacgggt atgattgcag atgtatcggc 1936081 atcagcaacc gctacagtga tgtaattgtc ttgttccttt tcaggaacga caaacgatgt 1936141 ctgatccaag gacgatgcag cttttgggct gtcttctgtc tcagttttcg ttactgcgtt 1936201 ctcttgggac gcttcttttt gttgaggctg tgcctgatca aagaaatgag gagaaataat 1936261 gaaggcgata taaaccgcaa ttgcagcggc acacgcgggg ccaatccacc tgacagcggg 1936321 cttattttta cgctttgcca tcgtcagccg cttgtaaata tcctgaggcg aacgatggtc 1936381 tttaactgcc ggaagttgac ttaacaactc ctttatctgt tcttcgttcc attctgactt 1936441 catcatccat tagctcctcc ctcaaaagct ccatatgttt ccgaagtact ttgagccctc 1936501 tgtgttgggt cgtttttact ttgctttccg agaagcgcag agccttggct gtttcctgta 1936561 ttgaatatcc ctgaataaac cgcaagataa tcacagctct ttgatcgatt gtacattgat 1936621 caagcgcagc ataaatttcc cggacatttt catgttgaac cgcaagttcg tccggcagca 1936681 attgctgatc cctgacatcc tgtgtatccc agtcaaatgt accgagtata cgctgtctga 1936741 ttgtttgctg tttacggaac cagtctatcg caacatggcg tgcgatagac aaaagccatg 1936801 ttttttcact gcttcttcct tcaaacgtat gataagaatt taatacccgg atataaacct 1936861 cttgaagaag gtcttctgtc tggtttttat cctttaccat ataaaataaa aattggtaca 1936921 aatcttgatg atatgtatca tataataatt gaaaggtttc ttccatttga aacccctccg 1936981 ttcacttttt tgtcgtatga atagcttgaa aagttacatt acaactatat tacgagtaac 1937041 tggaatttgg aagggaattt atattaacat atccttaaat tttattaatg ttggctatta 1937101 aaaaaacacc cgctcagtca gcgggtgttt cttatggaac aagattcttc ggcaaattca 1937161 gactcgattt taccgttttg tcggaatata aaaagaaaat gttgttcctt tatctattcg 1937221 gctgtgcaca gtaattgatc cgttgtgggc ttccacgata tttttaacga tagccagccc 1937281 taacccggtt cctgctctgc cccttgtccg cgctttatct gccttataaa accgctcaaa 1937341 gataaatggc agatcttctt ccggtatgcc agacccggag tctttgatat caattttcaa 1937401 tccatccttc acagaatgga ctgaaatgga gacactgccg ccggctgaag tatgccgcag 1937461 cgcgttatca atcaaattgg taaatacctg ctccatcttg tcttcatcaa acataaattc 1937521 ctcttctgtg agagaaatgt catgatctaa agcaatattt ttttctttcg caacaccgga 1937581 aaacttccga atgatctttt ctaaaaactc attcacattg attttttcat aatgtaagcc 1937641 tgtatggcct gattccattc gggctaaatc aagcaaatca ttaactaaac ggcccattcg 1937701 gagcgattcg tcataaatga tttgggcaat ttctttccgg tcttcttcag agcttgcaat 1937761 gtcatcgaca attgcttcac tgtatccctg aagcatggag atcggtgttc tcagctcatg 1937821 actgacattt gcgataaagt cctcccgcag cttatcaagg cggcgttctt ctgtcatgtc 1937881 acgcagtacg gcaaccgctc ctctgacgtg cgattccgca taaagcggcg acatcaaaag 1937941 cacccatgat ctgccttgaa gcgtcatctc aatcatttgt tctttttcag tgctgacagc 1938001 gttttgaaac agctcttttg cttcaggcgg aagattgtcg ccttctttga tattcatgtt 1938061 ctgttcataa taccaagcct gaagaaaacg ttcagccggc gggttggtca caagaatcgt 1938121 accgtcaata ttaatggtaa taaccccgtc agccatactg ctcaaaatgt tagaaagctg 1938181 ctctttttct tgattgagcg cattgatatg aaagttaagc tgccggccca tttgattaaa 1938241 agcggtcgcc agttcaccga tttcatcctg agttaaaatc gggatttttg tatcgaactt 1938301 gcccttcgcc aaatcctgcg cgccttctct catttttcgg agagggtacg tgaccctgct 1938361 tgataaaaag aatgcgaaaa atgtggtcag cacaatcgca attccagcgg caagaaaaat 1938421 atagcgggtc gtatgttttg ttgtatcttt aacggcaagc aaagactggg ataaaaagac 1938481 catgcctttc tttccgtctt tttcatacgg gacacctaca atcaggcgtt cattatccgt 1938541 gtctgtatcg ctcagtcccg tccgtttgct tactttttta tggtctttga gagctttatt 1938601 taagtctttg tcatgctgta tttgctcaac cgtaatagac gacaggcgat ttttatcatt 1938661 cggagaatac cagtggttct tctcatcctg gatgatggca atgcttgtta agttatcagc 1938721 gagttcccaa gtgattgacc ttgccagtgc ctggtcctcg tgattttcta ggatgacagc 1938781 aactttattc gcaagctgtg ttaaatcatt ctcagcttct tccacatggt agttttcaat 1938841 aaactccagc aaaagaaccg ttaaaatgaa caatacgatc aagacgagtg aaaggatcgt 1938901 aaaccacagc ttgcctacta cgcttttcca aaatttcatt cagcgccgac ctcaaattta 1938961 taacctacac cccatacggt gacaattttt ttcgcagctt ccggagatac cttgttcagc 1939021 ttctctctca agcgtttgac gtgagtgtcc actgtccgta aatcaccaaa aaactcatat 1939081 tgccacactt ctttcagaag cttttcccga tcatacacct tgtcaggcgt tttcgctaag 1939141 aaatatagaa gctcatactc ttttggcgtc aggctcactt ctgttccatc agctgttacg 1939201 cggtgagcat catggtctat tgacagatgt gaaaacacga gcacattttt cgtcggtgta 1939261 ttggcattga aataagaggt ttgggatgct cttctcaaaa gggcctttac acgcagcacg 1939321 acttctctcg ggctgaacgg cttaacaata taatcatctg ttcccgcttc aaacccctgc 1939381 acccggtttg cttcttctcc ttttgcggtc agcataataa tgggtgtcgc ttttttttca 1939441 cgaatttgcc ggcacacttc aattccatca gtccccggca tcatcagatc aagcaaaatt 1939501 aagtcataat tggcttcaag ccctttggca atggcttcat caccattttc agcttcatct 1939561 atagcataat tttcacgttc aagatacatt cttaaaaggc ggcgaattct ggcttcgtca 1939621 tcaactacta atatttttgt ttcgttcgtt tggtccatgt tttccccctg ctttccttct 1939681 gttactttca ttttatcaaa tcgtgagaaa gtttgagaac tgtgtcgctt tcaaaggact 1939741 atgcataaga atgaagtccg gcaagcacaa gatttacgaa tattaaatta aacataataa 1939801 tagcaaaacc gattacggcc agccatgctg acttctcacc gtgccagcct cttgacagtc 1939861 ttaaatgcaa gtaagcggca tagaacaaaa atgtgatcag cgcccatact tccttagggt 1939921 cccagcccca aaatctggtc cacgcgagct gagcccaaat cattgcaaag atcagcgcgc 1939981 cgagtgtaaa gatcggaaat ccgattgata cggccctgta cccaacctca tccaccagat 1940041 caagattgac gtttttcacc agcggatgta atagagcgct gattcttttt ctgatgatca 1940101 gacggagagc cccatacaac acaagacctg ctccaaatga ccaaatgaca gtgttcactt 1940161 ttctgcctga gaaaagcgcg ggaagatcaa caagcggttc cattcttcct tcggtcaaaa 1940221 gctctccctg atgcggaccg acaagcgcgg gcatttcgta caccatcacg cttttttctt 1940281 tacttttgtc cacccagtta aactccgctt catagcctgc aagacgaaat gccgatgtga 1940341 ttgcaataaa ggcgacggtt gtgaccagga taaacataat cgcttcaagc cagaaggtct 1940401 ttttgcttgg ctttgtctgg tctacatgct tcaaaagaaa gatgacacca gcgacaaagc 1940461 tgatggcaag tatagcttgc ccaagcgcgg ccgttgttac gtgaatatac agccagttac 1940521 tttggagcga aggaattaaa ggcgagatat ctgtcggaaa catgctggcg taggcaatca 1940581 gcaataaagc aattgacagc gtaaacaggc ctaatgaagg caatctatag agaaaataaa 1940641 gaatgataaa cgccaaaaca agcatcatgc caaaagcggt ggtgaattca aacatattgc 1940701 tgacaggcgc atggccgctt gcagcccacc ttgtgatgaa atatcctagg tggcagaaaa 1940761 aaccgacaat agaaagggtg attccaatgt tggcccatcg gtttggcctg ccctttttat 1940821 ctttattccc gcgtatggcc ccgccgaaga ttgggacagc gattaaatac acaagaaagg 1940881 ccgcataaag aaaatttccg ctcagctctg ccatgacatc actccctttt cgcctatttc 1940941 tgtgttttga ttaattcttt ttggtccacc ggttcagtca gtccggaatc agccaatata 1941001 aatgctaaat ccttcttcag gccaaaccag tttttattgg tatgccctgc taccataact 1941061 gcaccgtcct gtgagtgcag ccaaattctt cgatgctgcc agtacatacc ttgaatgaca 1941121 ccgatcataa aaatggctcc gccgacagca agcacccaga gtgtcagatc ctttctgact 1941181 gtaagtccag taatgttttt cgtttcgaca tggtcaaatt tcagcttgta tttattattg 1941241 cctgatcctt cgatggtttc ttggatggcg acaaagctct tttcgccttt cggtttgtcc 1941301 ggcgttatga tattaaagac aaaagccgga ttgttaggga tctttgtttt tgtgctcggc 1941361 tctccgtcct gattaaaata gaagtcaggc aggtagctgg cgatttccac cttgtaaccg 1941421 ttaccaagat catagactga atctggatcc agaaggttga tcttcaggct cccaaaggat 1941481 ttttttgttt ttttatcaat cagctggaac accatttggt caagctgatt ctctttgtaa 1941541 tccacctggt aaacggaaaa agaatcaaaa cgcagcggct gattgacacg gatgtcttct 1941601 tctgttactt tttccagctt cggcttctcg ccataaacaa tttttccttc tctcttgtag 1941661 agtacggcat cagtttgaaa gttctttgcc actctaccgt ccccgactct gtcaatggca 1941721 tctgcaaata cctttttttc cgttttgctg ttataggtct ctacgctgaa ttgattgttt 1941781 ttcaaataat attttccgtc tgtacccgga attgctgcgg tttcgccttc tctgacccaa 1941841 agcgtctcat cgacgtacat gccaggcaca aatctcagca tcgcaccaat cagaaagatg 1941901 atcaatccaa tgtggttgac atacgggccc cagcgggaaa agcgtccttt ttcagcaaga 1941961 atgctgccct ctttttctct gattctataa tgttttttct ttaatagagt aactatcttt 1942021 tctttcgatt ccccgttcag tacagtaact gtttcactga acaagcgctg ccttcttaaa 1942081 aaggccgggc tccttctgac accttggttt tttaacgctc tatacaacgg aatgacccga 1942141 tcaaggctgc aaatcacgag tgaaatgccg atcgaggcaa tgagcagcaa ataccaccaa 1942201 gaaccatata aatgatgaaa cccgagcaaa taataaagct ggccaaacgt gccgtactgc 1942261 tccttgtaat aagtatcagc ctgtgcgccc ggaggcagat aggcttcctg gggaaaaatg 1942321 gtgccgaacg ctgatgcggc aagggttatg acgataagcc atattcccac cttaaccgag 1942381 gaaaagaaat tccaaatttt gtcgatgatc gttttgttat aggtttgcga acgtcttgcg 1942441 cttccgtcat atctcatatc agcgagcgga ggttgagttt cctgaagagc tcttccgcac 1942501 gattcgcata aaacggttcc gaccgggttt atatgtccgc attcacattt gacttgcttc 1942561 atcccgaagt ctctccgggt tttatgagat tcatataatc gtgtatcatg ctttctgtca 1942621 tagtgccggt caccaccttg acaacttttc cttccggatt gatcaaaaag gttgtcggaa 1942681 gcggagatac gtcataggca tcaagcactt ggcgatctgt atccagaaca accgggaaat 1942741 tgactccgta ggatttcata aaattatgta ctgctatctt tgactcccca acatttacag 1942801 cgacaatttc aacaccttgg cttttaaaat gcttatattg gtttgccata taaggaaact 1942861 cttttttgca cggttcacac catgtacccc agaaattcaa aaaaacacct ttccctttta 1942921 agtcactgag ctcgatacgt ttcccattcg tatcctctag gacaaaattc ggtgcgtcgg 1942981 acccttcgga tatactctct ttgccggcaa atacagcgtt gtaaatggta tagccgagtg 1943041 cgcagattaa aacgagaagg atgccggtcc gaatgaataa acgccttttt ttcttcattg 1943101 tccactgccc ccttccccct attgcagatc cattcaatta tatcattgca cgttcatttc 1943161 acatttctta ctttttgaag gttatgtgaa atttagaaag cgtttttacc gtgatccgcc 1943221 agtgctctga gcctttttac ttcgtgaggc gtaagctctc tggcatcgcc cgtgtgcagg 1943281 cctcgcaggt ttaaaaacgc gtattcctca cgcttcagct tgattacctc atgtccgatc 1943341 gcttcaaaca tgcggcgcac ttgtctgttg cgtccctcat ggatcgtcag ctgaataatg 1943401 cttgtctgct ttttcttatc caaagacagc agcttcgctt tagcaggcgc tgttttgcct 1943461 tcctccagcc taattccgcg ctccagcttt ctgagcagct ctttaggcgg gattcctttc 1943521 accttcgcca cgtatgtttt gtctatttca tacttaggat gcattagctt attggcgaat 1943581 tcgccgtcat tggttaaaag caaaagaccg ctcgtatcat agtccagacg cccaatcgga 1943641 taaatgcgct gcggaatatt tttaaaaaag tccgtcacca ctttgcgtcc tttatcatct 1943701 tgcgctgcgg aaataacgcc tcttggttta tataagagaa agtaaaccgg ctcttcgcgt 1943761 tcaaccttta acccgtttac ctcaatctga tcagaaccgg tgaccttaac acctagctct 1943821 gttactactt tgccattcac ctttactttt ccttctttaa tcagctcttc tgcctttctg 1943881 cgcgacgcaa ctccggcatg agcaatcact ttttgcagtc tttccatgtc tttcacctca 1943941 agtattatct tacttttttc aaccttaaca aacaagcttt ttcaaattcc tatgccaaat 1944001 ctaaaaaaaa cgccgttttc aggcgctccc aaataataac gtaacgatga tgatagatgc 1944061 aactacgccg attaaatctg caagaagtcc cacctttaat gcatcaccca tttttttaat 1944121 gccgactgct ccgaaataca cagtcagtac gtaaagcgtt gtatctgtag atccctgcat 1944181 gacggaagcc agcctgccga taaaggaatc gggcccgtat actgcaatta aatcggtcgt 1944241 cattccaagt gcggccgtac cggagatcgg gcggatcaga gcaagcggca ctacttcagc 1944301 agggatgccg atagcggaga aagccggttt taaaagatcc attataaaat caagcgcgcc 1944361 tgatgatctg aaaacagtta tagcgacaag cattccgact aaatagggga taatggaaaa 1944421 ggcaatttct atcccctctt tcccgccttc gacaaacgat tcatatgtcg gaaccttttt 1944481 gatcgttcca taaagaagaa ttccggcaat aatgattgga atcatggcta aagacagcca 1944541 gttgatgatt tccatccgct caccttccct tctttttgcg gcggtaataa aaataccgat 1944601 caatgataat ggcaccgatt ccggaaataa gcgttgccaa aatgcttggc ccgacgatat 1944661 ctgtcggcgt tttggaggaa taagccattc ggacagcgat caccgttgtc gggatgagtg 1944721 tgatgcagga cgtattaaca gctaaaaaag taatcatcga ccggcttgct tccgatcggt 1944781 ttccgttcag ctttttcatt tgttccattg ctttaatgcc aagcggagtt gctgcatttc 1944841 cgaggccgaa gaaattcgcc ataagattag ataaaatata gcccatcgcc gggtgatccg 1944901 gcggtatatc agggaacagt ttagatataa aaggtctgca catccggctg aaaatatcca 1944961 aaagccctga ctgctcggcg attttcatta agccaagcca gaaaacaagc acgctcatca 1945021 atccaaatga gatcgtaatc gcttctttcg cacccttaaa cacggcttca tttacatctt 1945081 gcagagttcc gttgcacatc gcaaaaacga gtccgatcac ggttaaactg acccaaatta 1945141 tattgaccat tttgctccgc ctgccgcatt cagaaagatt gatttaaacg tttcaaaaaa 1945201 ttgtttcttc ggtttttgat gccgctcatt ttcataatag atcggcactt ttgcgatggt 1945261 tgcatcgttg aacatgatct ccatgtgccc tacgatgtca gggattttcg aggcatcttt 1945321 ttcccatgct tttttcggct tgagcagtgt ggtattaatt tttacatttt ctttttcctc 1945381 ttcggtcagc aaataggtga tatcacgttt gataaaagcc ttcgattcat aaaatgtgcc 1945441 tttcagcttt ggaatatccc ctttttttgc aattaaatag gtttgataat gctcaaacac 1945501 atagttaaac atcttcatat ggtcatccca atcattaggg tcattaatgg tgacggctat 1945561 caggtcaatg ccgtcctttg aagccgtaga gaccagtgtc cgttttgcaa gttttgtata 1945621 gcctgttttt cctcctgtgc tgtacggata aagcatggtc agcagtttgt ttttgttttt 1945681 ccatacgctt tccatcgttt ccgctttgta tatttttgtg cctgaaatct tttgatagtc 1945741 tttcagcttc atagcatact tagttaaaat ggccatgtca taggctgttg aataatgatt 1945801 ttcatggtcg tccaatccgt gcgggttttg aaaacgggtg tttttcatac caagctgctc 1945861 ggctttttga ttcatcatat aaacaaaccc atcgaggctc ccaccgacat gctcagcaat 1945921 cgcgacagcg gcatcgtttc ctgatcttag catcaggcca tacacaagat ctttcagctt 1945981 cactttttga ccttctgtta aataaatggc ggagccttct gttctgacag catttgccga 1946041 aaccgtcact gtttgatcca ttttgccgga ttcgatggcg aggacggcgg tcataatttt 1946101 tgtgatgctc gcgatccgcc ttttttgatg ctcatccttg gcatataaca ctctgcctga 1946161 cgcaccgtca ataatgatcg cgctttttgc actgacatct atagcagcat gtgctgtatt 1946221 cacatttacg gttgcaataa gaaaagaaat catgatcacg aatactgctt ttttgaaaat 1946281 gcgcatgttt gctcacgtcc ttgtggtggt ttgtacaagt ttatgcgcat gtccatcagt 1946341 tatgaataac aattatattt ctggaagcaa acataaaaaa actctccctg aaaaagggag 1946401 agtaaacgtt atctgattgg cgccatgctt gatccggacg cttcgtaatg agccagctct 1946461 tccctcatct tcagaaaggc cgcgctcaac ggcaataata attgctcaag cgacgcagga 1946521 acagcatgat aaaactcaat tgcgctgacc ccggtataag acgcccggct attttcacac 1946581 cacgtgtctt ttttcggcat aaagaactct tcaatgcatt ggtgatacac attataaagt 1946641 gttttttccg ctctggcttc ctgaaaaggc tcctgcatca ggagacgacg gcacgcttct 1946701 gcgcctcctt cacaaaatac tgccattctt ctcagagtgc taagcacatc acagcagtat 1946761 cctttttcaa taggcaattc agcctgtaag gactcaagcg tcgtttgatt taggtaatcg 1946821 ttcacggtat tgacaaccat tgataagaat tcgcctgttt tttgagtctg cgctcgcaca 1946881 atcgaatgtc ccatttcgtt tggtatcttc ccctcatgta tttgtctctc acattttgct 1946941 tctttcatga tagcttcttc cttatatctt atgatgatga aaaagcgcga ttcattaaac 1947001 ttctatttta tatcttcgaa ggtttggtta aagttttcaa aaaataaatc tgcttcttct 1947061 tgaagaacgt cttcttccgc attttcaggc agcggcggaa gctcgtccag cgttttcaga 1947121 ccgaattgtt caagaaaagt cggcgtagta ccgtataaaa tggcccgccc cggaccatcg 1947181 gcacgcccta cttcacacaa tagcgccttc gcgacaagac tgtgtaaaat ccgctctgat 1947241 tttactcctc tgatttcttc aatttctgct ctcgtaattg gctgtttgta tgaaacaatg 1947301 gccagtactt ctaaagatgc ttgagaaagg ccctttgacg gcacttcaat cagttttttc 1947361 aagtaaggcg caaagtcttt tttggtagag agcatgtacg tatctgcata ctcaataagt 1947421 tcaatccctc gtgtatctcc gcggtattcg tccgccacat ccgccatgat cgtgttcagt 1947481 tcaggctctt cgatttcaag cactgttaac agctgctttt ttgtaagccc ttcatcgcct 1947541 gccgcataaa gaagggcttc cacaatagct ttccaattca cgatatcaag ccccatgaat 1947601 ggattcactc cccgtaatgt aaatatctga aaaattgtgc tcctgttcaa tgaggaccag 1947661 ctgatttttc atcagctcaa gaacagctag aaaggtcact actaaatgtt ctttttgctc 1947721 atatggaaac agatccataa agttaattct cgttcctcta gatttcaagc tgtgcacgat 1947781 ttcgttcatt ctggcttcga ttggtatgtc ctgtcttgta attgttgttt ccatcggcct 1947841 gtttattttt ttgcgtttca gcactttttg aaaagctccg atcatatcat agaccgtgac 1947901 agagagcttt tgctcagact gttttacttc ttttgcatat tcactcaaat cactcggcgg 1947961 tttcgtgaac gatttttgtc tttcttcttc ccgttctttt aaatccttcg ccgcatcttt 1948021 atattttcgg tactcaatca gcttttcaat cagttcctcc cgcggatctt cttcttcaag 1948081 taattcatct tcaaaaagct cctcctcttg cttcgggagc agcattctgc ttttaatgct 1948141 gagcagcgtg gcagccataa ccaaatactc gctggcaatg tcgagctcaa gcacgcgcat 1948201 cgtatgtaca tataataaat attgttcagt gatcttcgcc acaggtatat catatatgtc 1948261 aatttcaaga cgattgatta aatgaagcag caggtccaat gggccctcaa acgtatcaat 1948321 tttcacttga tattcttcca tcatctcacc attttcaagt atcactctca ttgccggaaa 1948381 aactggctac cctatagtat aagccaccaa aaagctctcg tccaatacta tttcatatcc 1948441 tgttttgaag gagtttgtac agaatattca aaacacaaga ggtgtttgct cggagcgcag 1948501 aagcgggaga aaaagccttt gcttctggtt ttcctttcta agaagcacta gaggccgggc 1948561 gttctttttt ccttttatcc cttctatggt acactaaaag cacattaaag gaggaagcac 1948621 cttgtatccg aaagcttata tagattatct cgttgagttt catgcgacac gggattattt 1948681 tgaatgccat gaaatattag aagaatattg gaaggaagat ccgccaaaga aacgaaaacg 1948741 ctattgggtg ggctttattc agcttgcagt ggctttatat catcacagaa ggcagaatac 1948801 agccggggca aaaagactga tggcgaacag catccggatt cttcaagcag aacaccgggc 1948861 agtcgaagac ttagggcttg atcatggccg tttgctcgaa cttatgcaat cggtttacga 1948921 acaaatcgaa accgtctctg cctataaaag cattatactg ccaatcaaag atgagaaact 1948981 ggaggaagca tgcaggatcg aatgcaggaa aaaaaagtat acatgggggc agcccagtgc 1949041 actcagcaac atatttctta tcgacaaaca ccgtttgcgg gatcggactg acgtcatccg 1949101 tgaacgtgaa aaagaaatag aacgcagaaa aaaaagcaga gactgatcac agcctctgct 1949161 taattattgt atgaaatgtc ttgatcctgc tgaccttgac aacgttcgaa aaagctctgc 1949221 gttaattcat ttggaaccag tacttgcgtt ttgaataaat gctttaaagc atccatcatc 1949281 tgttttccga ttccttgatg gcgatgagaa ggattcacac tgatatgccg gatctcaacc 1949341 tcagaatcct ttttttcgac tccgattgct ccgacgatat cctcgtcctc tttccaaaga 1949401 aagagctggc ggtctgtatc cgtttcgtag tccttaattg tctgctgaag ctgcttaagg 1949461 tctttttcat tcggcataaa cgaaagaagc cccatcgcaa tcttttcaaa cgatttttta 1949521 taacgaatta acataaaaac ccctctatat ccaaaatgtc cagtctgcta ttaacggata 1949581 cgaataggtg atccgttttc tcacattata tcattttcgc catattttta aactgttttc 1949641 agcaaattat tcaaatgagc ggtttaaatt tgccatttca atggcagaaa cagcacaatc 1949701 tacacctttg ttgcccgctt ttgtgccggc acgctcgata gcctgttcga tgttttcagt 1949761 tgttacaatt ccaaagatga caggtacacc agtagtgttt gctgcttgcg cgatgccttt 1949821 tgcagcttca ttgcagacat aatcgtaatg tgtcgttgcg cctctgatga cagtgcccaa 1949881 tgtgataata gcatcatatt tttttgtttc cgccattttt ttcgcagcaa acggtatttc 1949941 aaatgcgcct ggaacccaag ccacatcaat gtcatttgtg tctacgccat gtctgagcag 1950001 cgcatcttct gctccgctca gcagcttgct cgtaataaaa tcattaaatc ttcctactac 1950061 gattccgatt ttaagacctg taccaactaa atttccttgt atgatattca tatgattccc 1950121 atcctttttt gtgatatttg tgattagaaa tgaagtaaat gacctagctt gttcattttg 1950181 gtttgcaaat attttttatt gtgttctttc gcctccattt gaagcggcac tctttctgaa 1950241 atactgagtc cgtagccttc aaggcctgcg atttttcgcg gattattcgt caaaagcttc 1950301 atattccgga caccgaggtc gcgtaaaatt tgtgctccga tgccatagtt gcgaagatcc 1950361 ggcaagaatc caagcgcctc attggcttct acggtgtcat agccttgttc ctgaagctta 1950421 taagctttta atttattgat taaaccgatg cctcgtcctt cttggcgcaa gtacaggagc 1950481 actccacggc cttctgcggc aatttggttc agcgcggcgt gcagctgcgg tccgcaatca 1950541 cagcgatgag agccaaacac gtcacctgtg agacattctg aatgcacccg gaccaatacc 1950601 ggttcttctc cgaacggcac atctcccatc acaaatgcga catgctcttt tccatctacc 1950661 tcatttgtgt atccataaac cttaaatgtc ccaaaatcag taggcagcgt aatgtcaact 1950721 tcacgctcga caagtgttgt cagattgtaa cggtattgaa tcaaatcctt aatggtgatc 1950781 atttttaatt gatgcttttt cgcaatttca atgagctcag gcactctcgc catcgttccg 1950841 tcttcattca taatttcaca aatgacgccg gctcctggag atccgcaagc ttcagcaaga 1950901 tcaacagcag cttctgtatg gcccgctctt ttcaggacac ctcctttttt cgcaatcagt 1950961 ggaaaaatgt gccccggacg ctgaaaatca gatggcacgg atttgctgtc cagcaatgct 1951021 tgaacggtaa aagatctttc ttgagcgctg atacctgtct tcgtttcacg atggtctatg 1951081 cttacggtaa atgcagtgtg gtgagagtct gtattatgct caaccatagg gtgaagatca 1951141 agcctgtctg cgatttcctc actgagcggc gtgcagatca gtcctctccc atgtgtcgcc 1951201 ataaagttaa tgacttccgg cgttgcatgc tcggcaagag ccacaaagtc tccttcattt 1951261 tctctgtctt catcatctac aacgatgatg acttcgcctt tttttaaagc gtccagtgct 1951321 tcttctatcg gatgaaacat gcaaatcttc ctctctaaaa gccgttttcg cttaagaagg 1951381 cttttgtaat ggtttgttgg gtcttatttt cattggcttt atgcaaaaat cgatacatat 1951441 attttccgat catatcgcat tcgatattca ctttagagcc gatcgttttt tctgaaaaga 1951501 tcgtttcgct gatcgtatgc ggtattaagg agatcgtcac tgtgtcttct gtcaggccga 1951561 atatggttaa gctcacgcca tccacagtaa ttgatccctt taaaaccaat gtttttgtta 1951621 atgacgggtc catttttaaa tcatagtaaa ctgcgttgct tttctcttca attcgtgtga 1951681 tttccgcagt tccgtcgaca tggcctgaga cgaaatggcc tccgaaacgg ccgtttgccg 1951741 ccatcgctct ttccagattt actttgcttc cttttgttaa atcattcagt gacgtagctt 1951801 tgactgtttc aggcataaca tccactgtga attgattttt tgtaaaatca gtgacagtca 1951861 gacaaatgcc gttcactgca atgctgtcgc caagatgaac atcctctaaa atctttgagc 1951921 atttaatagt taaggccatt gcatgccctg cttttttcat ggattcgatt gtgcctgttt 1951981 cttcgataat tcctgtaaac atggtcacca tcctattcct ttgtcggttt tgccgtcagt 1952041 ttgatatcac ggccgatttg ggttatatca gtgaattgta ataaggggac atctttcatt 1952101 gattgaaaac cttcaccgga gattaagctg ggagcatgcg ttcctccgat tagtttaggg 1952161 gcaaaataga agatgatttc ttgaaaacag ccttctttga caaagcttcc gtgaacagct 1952221 gaaccgcctt ccacatacac cgacatgatg ccttcttccg ctaggatctt caaaacatca 1952281 ggaatttgaa tgcgctcggt ttcaagtgta aatatgttca ctccgaaagc tgaaagccgt 1952341 tttttctttt cctcgtctgc gcgtgccgtc gtaaaaatcc atgtcggcgc tatttgatcg 1952401 caaatcactt tagcgtcctc aggaatcgag agtacggtat caagtatgac ccgaaccggc 1952461 tgttttgtta cattcggcag tctgcaggtt aagctcggat tgtcggcttt cactgtgcca 1952521 actccgacta aaatgctttg gtgtgttttc ctgtattgct gagcatcctg tcttgcagcc 1952581 tctgacgtga tccatttgct gtcacccgtg ctggtagcta tcttgccgtc aaggctggca 1952641 gccgctttta gcgtgacgta cggaaggcct gtcctcataa agtgcagaaa tttttcattc 1952701 agcctctccg cctggtctgc caggatgcct tcccttacct caatgccagc ttctttcatc 1952761 atgctgatcc ctcttccagc cacaagcgga ttaggatctc tcatcgccac gaacactctt 1952821 ttgataccag agttgataat caattctgca catggcggtg tttttccgta atggctgcac 1952881 ggttcgagtg taacgtaaat gtcggcaccc tctgcatgtg ctccagccat atggatggca 1952941 tgaacttctg catgagcttc accatatttt aaatgggcgc ccattccgac aatttgtccg 1953001 tcctttacga caacagcgcc gacgagcgga ttggattcgg tctgtccttc gccctgcttc 1953061 gcaagatcta aggccagctt catataatac tcttccattt gtttccctcc cctcttttgt 1953121 tatttaccgt caaaaaagcc ccgaatttat aaaaaattcg gggctttagg tattttacgc 1953181 aataggaaat aacactatgc atttttaaac attttgcata gcggctcatc atccttctcc 1953241 catccagact ttcactgtcg gcttcagctt aaactgaatc caccgcgtgc ttatgcacac 1953301 gggtcacggg ctctaaagca aatgtgcttt actaccgccg gtcgggattt ccaccctgcc 1953361 ccgaaggata caatctttat tcatttgtcc ttattggtta ttatagcgat cctttttaaa 1953421 gtacgcaatg aaataaactt acaatttgag aaaaacaaaa catcaccctt cgatccgaaa 1953481 ggtgatgttt tttaatcatt cacttttgca accttgatta atccgtcgat ccgctttgat 1953541 ttgctgaagt aagccttaat cttgtcacct tcttttatat cagataaatc ctgatttaat 1953601 ttttttccgt tgaagatgat tttcgttccg ttttctgcta ctccatgata ctctgagccg 1953661 tcaattttcg tcactttata ttcctggatg gtgtattcct cttcttccga ggacaaggtt 1953721 tgtccaattg ctgtcggaac atccttcagc tcaatatcat ttatgtacat ataaccgcct 1953781 gcaagtaaaa gcaaaagcac taacagaatg gtaatcttgg tttttattct tcccatttct 1953841 aaacctccag ccaatatgaa tctattcatt catatgagtt attccttttt ttcatgaata 1953901 aaaaaccgta aattctcgta aattattaat ataacgatgc ataacgggaa tatgtttcac 1953961 atttctgcaa aaatttcttt tctatagata tacgaattta tgttctgttt ttaggggatg 1954021 accgtaaaaa agatataaaa aaagcagccc caatgggaag ctgcttgatc ctaatttgtt 1954081 ttgcgcattt cgttaaacgg gtagaaaaca aactttgacg tacccgcaat ttgttttttc 1954141 gtgaagaggc caaggccgtt acggctgtcc atggaattgc gacgattgtc acccatcaca 1954201 aaatacttgt tatcaggcac tttaaccggg ccgaaatcat cggtcaaatg gtcaaaaccg 1954261 tcctgtttcg ctctcttttt attagccgcc aaataaggtt cgtccacctt tttcccgttg 1954321 atatagagct ggtcattttt catctcaacc gtatcgccgg gaaggccgat aatacgtttg 1954381 acatagtgaa catcatctcc gtttaacacg acgatgtctc ctctatcaaa ctcgccgatg 1954441 tatttgactg tcatattaac aaaaaccctt tcacggttgt gaagtgtagg atacatagag 1954501 tcaccatcaa cgacatacgg cgcaaaaata aagttgcgga tgagcaaagc aagaacgaca 1954561 gcaatcacaa ttgcttttgc ccattctaat attgactttt tcttcgaaac attttctgat 1954621 ttcaactgat ttcctccaat aaacaacggt cttcaattta tgttatcacg aatcgaaaaa 1954681 aaatcccatt aggaccattg aagtgatttt acaaactgtt aatcttcatc ttctacccac 1954741 atcatgccta ttttttcttg tcgatcataa ctaggcctga aaatattgaa agaaatgaat 1954801 cgcataattc agaagcgatg gactcagaag aaagagagtt ctcatatgca aaatctttag 1954861 atcgtatata aagcatgagg ttacgggcag tttgttcatt tactgcattc cattgatctc 1954921 ccagtccatg atacccatgg cacttgacaa aacaattaac gtcatgaagg ttactggaat 1954981 gtttgcggca acctatttca caggtgataa ccgcaccccg ttttttgctt tcataatatg 1955041 tttaaaatca ttcaagctcg aaaacatgga tcagcctcca aaaaataaat ccaatatatt 1955101 cccggcagtt gaagactctt tattataaaa ctctgaatat ccgcagttct tacagtaaac 1955161 cactagaaat cggttatgct gcacgtcaaa cagctttgat aatcccgtgc cggttgtagc 1955221 tatttctttt tgtccggctt cagtactacc gcattttata cagcctttgt tgttcatatc 1955281 gcgatctcct tttcattaca tcacgtttgt ttgatttatt ttactacaaa atatcaatcc 1955341 caatgacccg tactacttta aagtttactt aattttgatt acatactaat tgggttcgtt 1955401 tctcagcttg gtaaatcttc tggagaaacg gaaaagctcc atgaccaaaa cattcaaact 1955461 cagccaaaca ccgccgaagg cgtaacccgc agcaacatca ctcggatact gctcataaag 1955521 tacacacggc tcagcccgat gaggaataaa acgataataa acaaaaaaat gcaacagttt 1955581 gcagacgcgt cttgtgagaa tgacgaacaa aaagataagc acaaaaacca aaaatgacaa 1955641 atgccgttaa agtctgttcg ctcgggaatg gatataatac atgactttcc aaaggagcgt 1955701 gaacaggatg aagggaatga aagagccgtc tgattccctc ttcataaagc tccccaccaa 1955761 tgactaggaa aaataagaaa gagagttcga ttttccgatc ttgccctctg aataccgtcc 1955821 aaaaaaaagt tagaacaata acggctaaca gaacacctct cgacgcaaaa gctttctgaa 1955881 ttgcagctgg gcccagtcta tacccgatcc aatacgacat gctcactccc acagctcccc 1955941 aatccggccg ctaacatgct tagcacccag tttaactttt cttgaaacac gagaacaccg 1956001 gcaaactctc ccggtccaag taaagctaga agctctaaca tcaagacaat aaacaagacg 1956061 gcatatccgt actgttcgag caaccccgtc aaaacttgca tgtgattctc cttaaacttt 1956121 tttgttcttt tatcattccc aatccacttt ttgtataatc agcacaattt tatcttcagt 1956181 cgtccaacaa cattgtctat ggcgggatct tctctcatac attctttttt gacataggag 1956241 gagcaatagc atgaaatggg aggaaacaaa agatacgcag ggagtttgcc aaaattttgg 1956301 gcagttcgtt ctgccaccga gtcaggtgtt tgtttgccca cctcatccct tgtcaattcc 1956361 ccatttttcc cgtttgaggt tcgaaatggt aaagtatttc acttagtttc ttacatgaag 1956421 aggtaaattc tttgctcacc gaactaggat agcggcgtat ggcgatttct acattgcata 1956481 accactggtt atttagtgag ccgtgagcaa tgtatatgca ctttgagtca gcacaggatg 1956541 atcctattac attcgccaga aaagcagctg ccgcattcag agtagttaaa agaatagaca 1956601 gatatctggg cttccggaag ctttaaagga ggctcttttt tcgagcattt ttataaatca 1956661 ataaaaacag gcatctccta aatatttttg ccgataagtt tacgctaatc aactctagca 1956721 ctaatacata taaaaaatag aatgatatga aaggagactt gatagtatga ttgattatcc 1956781 tattaatata aacaacgttt ccgggaacag tgtaattaac gtaggcggcg cttttatgat 1956841 caggccttta actttgtcca aatctgtgtt tggctccgga ggtttaaaca caggaattgt 1956901 ctttgaaaat aactttgtaa gcaaagctaa aatgattaat catcaattta ctgatcaaaa 1956961 cgtcaccaaa actttttaat gtattcaata cacgggggtc actaactaaa cacctggttt 1957021 tgccaaccgc catcagcatt cggcggtttt ttattgaaca tttttggcca ataaaaaaag 1957081 cttcctctct aagaggaagc cttttgcctg ccgattagcc ttctacacga acttctttca 1957141 tgacatcgcc attagacatg tttttcgcga attctaatcc gcttgttact ttaccaaata 1957201 cagtgtgaac accgttcaaa tgaggctgtg gctcatgaac gatgaaaaat tggctgccgc 1957261 cagtgtcttt tccggcatgt gccatagaaa gtgcgcccgc ctcatgtgta tgcgggttgc 1957321 cttctgtttc acatttgatt gtgtatcccg gaccgcctgt accagttccg tgcgggcatc 1957381 cgccttggct gacgaagcca gggatcactc ggtggaatgt aagcccgtca taaaagcctt 1957441 cgttcgcaag cttttcaaag tttgcaacag ttccaggtgc agcttcagga taaagttcaa 1957501 attcaatttt gttcccgtct tctaataaaa agtaacctgt tttcaattgt atgcctactt 1957561 tctttatttt aattttcaaa ggagattatg tataggttat agcctgtctc tccttgtcgc 1957621 ggctattata ccacaccttt cgggggaaaa cgaatctccc gagctttact aaaaaataaa 1957681 aatgaaacct gaatctcttt atctccgtct aacctaacgg aactgtattt ttcatgattc 1957741 aggtcctcac aaagcagcac tatccagctg cttgtgaaat tgaaggaggt caaactgctt 1957801 tgaagaaaat ttggattgga atgctggcag cggccgtttt gctgctgatg gttccgaagg 1957861 tcagtctcgc ggatgccgca gttggagatg tcattgtaac actgggtgct gatttgtcag 1957921 aatctgacaa acaaaaagtg cttgatgaaa tgaatgtccc tgataatgcc acaacggtaa 1957981 ccgtgaccaa taaggaagaa catgaatatt taggaaaata tatatcgaac gcgcaaatcg 1958041 gatcgagagc gatttcttca tcgtcaatca ccattgccaa aaaaggctcc ggattgaatg 1958101 ttgagaccca taatatcagc ggcatcacag atgaaatgta cctgaatgca ctgatgacag 1958161 ccggtgttaa agatgcgaag gtgtatgtta cagcaccgtt tgaagtatcc gggactgccg 1958221 ctttaactgg attgattaag gcgtatgaag tttcttctga cgaagcgatc tcggaggatg 1958281 ttaagcaggt cgccaaccaa gagcttgtca cgacatcaga gcttggagac aaaatcggta 1958341 acgaaaatgc ggcagccctg attgcaaaaa tcaaagaaga gtttgctaaa aacggggtgc 1958401 ctgataataa agctgacatc gaaaaacaag tggatgacgc agcttctgat ttaaacgtca 1958461 cacttacaga cagccaaaag aatcagcttg tctccctatt caataagatg aaaaacgctg 1958521 acattgactg gggacaggtc agtgaccagc tagataaagc gaaagataag attacgaaat 1958581 tcatagaatc agatgaaggc aaaaacttca tccagaaagt cattgatttc ttcgtatcta 1958641 tctggaatgc gattgtatct atattcaaat aagaaaagcg ccgaaaaatc ggcgctttct 1958701 tttattgctt tacacccgtt ttaaatggca gatcaagttt tacaatatct tcgtatgttt 1958761 ctcgcttcac gactaaatga gcctcaccgt tttcgacaaa tacaacggcg ggtctcggaa 1958821 tacggttata attgttggcc atgctgtatc cataagcgcc tgtacaaaaa acggcaagaa 1958881 gatcgccttc ttttacttcc ggcaggtcaa tatcccaaat cagcatatct ccgctttcac 1958941 agcactttcc ggcaattgat accgttttgt catgcgcttc tccgatcctg ttggctgccg 1959001 cagcttcata tttagcttgg taaagcgcag gacgaatatt gtcgttcatg cctccgtcta 1959061 cagccacata ttggcggaca cccggcactt ctttttgaga gccaaccgta taaagagttg 1959121 tgcctgcgtc tcccacgaga gaacggcccg gttcgatcca aatttccgga atgtcaaaac 1959181 cgtaacggga agcattttct ttcacagctt cgataatttt ttcaacgtat tcagtggcat 1959241 gaagcggttc atcatcttcc gtataacgaa tgccgaaacc tcctccaaga ttcagcacct 1959301 tggatacaaa tgaatatgaa tctctccatt cgtctagttt tttgaagatt ttttccgctg 1959361 ctaacacaaa accggccgta tcaaagattt gcgagccgat atggcaatgg acacccagca 1959421 gctgaatgtg ttccgattgt aatacttgtt caatggcccg ttcagtttgt ccgttatgaa 1959481 gatcgaaacc aaactttgaa tcttcctggc ccgttgtaat gtagtcatgc gtatgcgctt 1959541 ctactccggg cgtgatccga agaagaacat cgatggagtg acccgtttct ttacataggt 1959601 cttcaagaag cgcgatttca tagaaattat ccaccacaat gcagccgatg cggtgctcaa 1959661 gcgccatccg cagttcttcc ctgctcttat tgtttccatg aaagtggatg cgttctgccg 1959721 gaaagcctgc tgcaacagcc gtatatagct ctcctccgga tacgacatct aaagaaagtc 1959781 cctcttcctc agcgagctga atcattgcga ctgatgagaa tgctttgctc gcatatgcca 1959841 cctgtgcttt cagccctgca gaaataaacg cctgcttaaa gcttttagca cgctcacgta 1959901 ttaaagccac atcatatacg taaagaggtg taccatattt ctccgctaaa tagagagcat 1959961 ccacacctcc gatttctaaa tgaccatgtt gattttgtct gcttgtgccg tgtaagaaca 1960021 atgtcattcc ctctttctcc gcttatggat gaaaggacag ttttatggac tgtcccttca 1960081 taattaagac atacattatc atactcttca gtcagtttca atgcgattat gaattggtag 1960141 gctgccttaa gcgatttttg gggtgaacga tgctgggtct tacttttgcg ccaggtttcg 1960201 ctgtgcggac aagaacctgc cacagcgcct ttccgttaaa gggaatcagc ggccataagt 1960261 acggtgtctg aagggatttg atgcttgcca tggcaataat tagcactgta aatccgatga 1960321 cgagcccttt tatatgaaat aaagcaacga gtatcatgag gacaagacgg ctcattttgt 1960381 ttgccaagct taattcataa ctaggcgtcg taaaggttcc aatcgccgca agtgagacgt 1960441 acagaatcac ctcaggagaa aaaaggccga cctcaatcgc aatctgcccg atcagaacag 1960501 cggcaattaa acccattgct gtcgataaag ccgtcggtgt gtgaatggca gccattctga 1960561 gaaactcgat tcctaagtca gctaaaaata tctgcaggat gatcgggata tgcgtatctt 1960621 tatttaaacc gataaatttc atgttgtccg ggagcagatc aggctgaagc acaaagagaa 1960681 accagatcgg aagaaataaa gtagaagcaa gaataccgaa aaatcttacc cgagctcgtg 1960741 gtcattcggc ataattactt aaattttgtc cagtctccca tcgtccgctt taagaatgtg 1960801 ataaacccgg ctttcttcat atcttctttt gcagcaacag gactttcagc gagtacttct 1960861 ccatcctttt tcagaacaag agtgccaagc tcttggcctt tttgaatcgg agcactaata 1960921 ttgtccttca tcttgatttc ttttttcaca tcgttcatat cctcgccttt tttcgtcaat 1960981 attgaaatcg gctcagatgt agtgagttcg ataaattttt gtttcccttt tttgaccttt 1961041 acttttgcta ctgtttgatt tcgtttatat aaaggatgcg tttcatattg gctaaaggcg 1961101 aagtcaagca tttttgtcac ttgcgcgttt ctttctttag gcgtgctcgc tccgaataca 1961161 accgctatgg cccgcatgtt tcctttttta gccgaagcag tcagacaata tttcgcttcg 1961221 cctgtatagc ctgtttttac gccgtctaca ccaggataaa atttgataag gcgatttgta 1961281 tttacaagcc aaaacttttt atctgtattt tcacgcagat aatcttcata cgtgccggta 1961341 aacttcgtaa ttgattcgta tttcaataat tccttagcca tgattgccat gtcataagca 1961401 gagctgtagt gtccttcctc ggtcagtcct gttgggtttt taaaggatgt atttttcaat 1961461 cccagctctt ttgctttttt attcattttc ttcacaaatt cttcttcaga gccggaaata 1961521 aattcagcca tggcgacgga agcgtcattt cccgaagcga ttgcgatgcc tttcagcatt 1961581 tctttgacag tcatttcttc gccgggctca aggaatatct gtgagccgcc cattgacgcc 1961641 gcatgctcgc ttgtacggac cttatcactc attttgattt tgcctttatc taaagcttcc 1961701 ataatcaaaa gcatcgtcat aattttcgtc atgcttgcag gcgccagtct ctcattgctg 1961761 ttcttgttgt aaagcacttt tcccgtgtca cgttctatca gcaccgcaga cttcgcttca 1961821 tgagcaagct ccgatgtacg ttttccgtct tgttttgcaa atgcagacgg tgcaaatgta 1961881 agcagcatta taccaatcaa caaagtggat aaaagacgtt tcatctcaaa agccctccat 1961941 ttcataatcc tttttatttt ttccaagcgt gatggtttta tacgccactg atggaaaatg 1962001 tttcgaattt tgggcataaa aaaagacagc tgtgtgatat cagacacagc tgtcttttgg 1962061 tcctgcattg attcatattt attcgtactg agcgacgatc gctttaacaa gctttaagaa 1962121 tccagctttt actttttcgg tcacttccat aacttcatcg tgacttaaag gctgatccag 1962181 aattccggct gccgcgttag agatgcagga aatgccaaga acccgcattc ccgcatgatt 1962241 cgctacaatg acttccggaa cagtagacat gccgactgca tcagagccca tcgttcttaa 1962301 gaaacggact tctgccggtg tttcgtaaga aggtcctgtc acagcagtgt acacgccttt 1962361 ttgaattggg atattaaggt ctttcgcaat cttttcagcc aggctggaca gatctttgtc 1962421 ataggctgaa gacatatctg gaaatctggc gccgaaatct gcttcgtttg gcccgattaa 1962481 cgggtttgtt cccataaagt tgatatgatc ggtaataatc attaaatctc ccgcacggaa 1962541 ttcagtgttg acaccgcctg cggcatttgt cacgatcaac gcttccacac cgagcgcttt 1962601 catcacgcgt acagggaatg tgactttctc cattgagtag ccttcataaa aatgaaagcg 1962661 gccctgcatt gcaatgacgg aaactccttc aagagtgcca agcacaagct gtccggcatg 1962721 cccttcaaca gtagataccg ggaattcagg tatatcttca tatttcagct tgaccggatt 1962781 ttcgatttcg tccgccaaaa tgccaagacc tgagcctaaa ataaggccga tctttggaga 1962841 ttccggcagg ttttgtttaa taaaagcggc tgcgcgttca attctgtcct tcaagaaaca 1962901 gtccccctat tgtaataaag ataaaaagct tttcccgtat ttcggtttat ttgtttggaa 1962961 attatcagcg atcgttgcgc caatatcggc aaatgtatct gcaagcggca gcatttgcgc 1963021 tttcttatgt tttttgctgt aagcgagaat cggcacatac tcgcgtgtat ggtcagtccc 1963081 atgatgaatc ggatcattgc cgtggtcggc tgtaataatt aacagatcgt cttctctcat 1963141 tttttcaaac acttccggaa gccgcgcatc aaattcttca agcgcgcgtc cgtagccttc 1963201 agggtcacgg cggtgtccga ataacgcgtc aaaatcaaca aggttcgcaa agctcagacc 1963261 cgtaaaatct tctcccagcg tatcgatcac cttgtccatt ccgtccatat tagaaaccgt 1963321 tctgcgtgaa gaagtaatgc cttctccgtc gtaaatatca gagattttac cgattgaaat 1963381 cacatctaag ccgcagtctt tcaattcatt catgacagtg cggtcaaacg gcttcagcgc 1963441 ataatcatgg cggtttggcg tccgtttgaa ttgacccggc tctccgacga acggccgtgc 1963501 aataatgcgg ccaaccatat atttcggatc aagcgtcagc tctctcgccg tttcgcaaat 1963561 gcgatacagc tcctcaagcg gcacaacctc ttcgtgagcg gcaatttgca gaacagagtc 1963621 agcagacgtg taaacaatta aagcccctgt ctccatgtgc tcctggccaa gctcatccaa 1963681 aatcgctgtg ccggaagccg gcttgtttcc aataattttg cggccagatc tcttttccag 1963741 ctcttgaagc aattcatcag gaaagccttc cgggaacact ttaaacggtt tatcaatgta 1963801 taaacccata atctcccaat ggccggtcat cgtatctttg ccgtttgacg cttcttgcat 1963861 ttttccataa taggcaagcg gatgttctgt tttttctaca cctttgatat cttcgataag 1963921 accaaggccg agctttgcca tattcggcat atgtaatccg ttcatatgct cggcaatatg 1963981 accgagcgta tgagcgcctt cgtcattaaa gtcagcggca tccggcgctt cgccgattcc 1964041 gactgagtcc atcacaatta aaaacacacg attatatttg tatgcaggca tcttgaaagc 1964101 ctcctttttt tctatacgtc tattgtatcg ctaagaggtc tgacaactca agtataaacc 1964161 gttttcattc ccgttgacaa tgtatttgga aataatgaga aacttcaata ttttctgtcg 1964221 ctctaaacaa aaaagccgca gccacctgcg gctatgctcg cggatgaaac tgcttgtaca 1964281 catccttcag ccttgttttc gtcacatgcg tataaatttg cgtcgtggat atatccgcat 1964341 gaccgagcat ttcctgcacc gctcttaaat ctgccccgtt ctcaagcaga tgcgtcgcaa 1964401 aggaatgcct gagtgtatgc ggagtcagct ctttcttaat gccggcttcc aatgcgattt 1964461 ttttcaggtt cttccaaaat ccctggcggc tgatctgttt gccgtgatga tttaaaaaga 1964521 gggcgtcaga tacattattt tttaacagtt ttcccctggc ttttgtcata tattcctcaa 1964581 tggcggaagc agcggcttca ccgattggca caatccgttc ttttcttcct ttgccgaagc 1964641 atcggataaa ccccatagat aaatgaacat cagccgtttt caattcaatc atttcactga 1964701 ctcgtatgcc tgtcgcataa agcagctcca gcattgcttt atcccgatat ccgaaagggc 1964761 tcgtcagctt aggcgtgtcc aataaccgct cgacttcatt gagcgcgagc accttcggaa 1964821 gcgcccgttc cgtcttttgt gtttcgatat gaacggaagg gtccttatcc gttacttttt 1964881 ccctgagcag aaattgatga aaagagcgaa tggatgccaa atgccgcgcc gatgtcttgc 1964941 cggatttccc cgagtccttc aaatgcttta agtattggat aatatgtatg cgggtaacgt 1965001 gattccaatc tgtaacatga agggtttctg ttaagtagag agaatagctt ttcaagtcac 1965061 gttcatagga tacgatcgta ttttgagaga gccctctctc taccataacg tagtggatga 1965121 aatcctttat ttgatctttc actcttgatc tactccccgt tttggtaaaa aaagatcaac 1965181 cggtcgaacc atccgccttt ttcatcctga tccatttcaa caacttttac agcggagcct 1965241 tccggtttat cataccgatg atagttttca tactcttgat tcacccatat catagcataa 1965301 tagaacaaag cggtaaaacc ggtaaacagg atgaaaactt tcaatgcatc gacagctgtt 1965361 ttcaggaatc ttcccatgtc ctaatcgatc ctttccctat ggttccagtt atataaacca 1965421 tatgccaaat cagaaaggtt ttatacatag aaacagcaaa aaaccctttc cccatgagaa 1965481 aaggttcgcg ctcggcaccg tctattcagt ttcttttccg ttacagcggt ggcaaatgcc 1965541 gtgaaacgtc aatctatgat ctttaatctt aaatttccaa tcacgttcaa tgatttcttc 1965601 cacgtcttca agcaaatctt cttcaatttc atcaacggct ccgcactcca tgcacaccaa 1965661 gtggtgatga aagtgagctg cgccctcttt ccgaaggtcg taacgggaca caccgtctcc 1965721 aaagttaatt ttatctacga cttttaattc agttaataat tcaagcgtac ggtatactgt 1965781 agcgagaccg atctcaggag atttctcttt tacgaggagg tatacatctt ctgcgcttaa 1965841 atggtcttct tcgttttcaa gcagcactct tactgtcgct tcacgctgtg gcgtaagttt 1965901 atagctggat gagtgcagtt gtttcttaat acgatcaata cggttttcca tgtctttccc 1965961 tcctacgccg cattccatga ctcattataa caaaatacgc gcagagttcc aactataatt 1966021 attataaact gataaataaa atggttttct tttaataatg attttaaaaa agtctagatg 1966081 taagcttttc cattaaaaca ggagataagt atgcttcaaa gagagatgaa atcagcgcta 1966141 aaaacagaat gaccagcagc acaaaggcat accgcccgaa ccattgaatc ggcgcgtcat 1966201 gcaggcttcg tttcacgaac agctgtctga ttaactttaa agaaaacgca attgcacatg 1966261 tgcccataat gagataagcc ggaatcagca gcacattttg cggcaaaacg gagacaaatg 1966321 ataggaaaaa cccgcttact cccatctgat tgactaggaa cccgacagta aagccgacga 1966381 cgatcccttt cagaaagatc ataatgaaaa taatcggcat cccaatgacg gaaattccca 1966441 gtatccacat caggcctaaa tactttgcat tatgaaagat actttgccca aacatatcag 1966501 ctgaacttgc ctgttttcca tccgaaagct gtccaaaaaa ttgacttaag tagtagtata 1966561 aatcttcttt ctggctgatg gtcatactgt tgacaataat cgcgccaaag atgacaccca 1966621 tgaaaaacag cactgacaca aatatataaa gagagagatg atctttgaca tgcctgagaa 1966681 acatgtcctt ataagagatt tttcgcatac cgtttcctcc cgcccgctct agtgatttga 1966741 tttaatagat tgtatgaaag aaacagaaaa acatgccctt tttcaaaaag aaacaataga 1966801 gatgaatgct aggcggcttt ttggggcaca aaaaaatcct tatcatcaac tgctgtatga 1966861 tcataaggat tcttatgctt ccgtttattc aaaatctctt ttttgctttt tgtcattctt 1966921 ccatgtgtgc tgaaagatgg tgtgctgcct cttgataata agacgtcacg tccgccgttt 1966981 ctcaatcgat gcccccgctt ctttttcgct tggctttttg ccatgtgatc actccctttt 1967041 ttattttcat agtaatgata acaaaattga acaatgataa gaaaaaaaca gcacctgcta 1967101 cgacaggtgc tgtttagcta catttatttc actgctgtaa gagctgcatg ctcgacagct 1967161 gctgctaccg catgatggac ttttgaatca agcggctgag ggacaacatc accttgttta 1967221 gtgcaagctg cgatggcctc tgctgctgcg acaagcatat catgattaat ctccgtgctt 1967281 tttgcgttaa gcgctcctct aaaaatccct ggaaaaccga gtacattatt aacagaacgc 1967341 ccgtcagctg catatgcggc gccagcctgc agtgcggcct ccggctcaat ttccggcttc 1967401 ggattcgata aagccagaat cacttgacca gaacgtacaa atgccggttt tattaaaccc 1967461 ggaacgcccg ttgtagcaat gacaatatca catgtttcca taagctcctc aatactggaa 1967521 actgcctgtc cgccgtattg ttcgagacgg ttcattgctg actctgattt gtctgttccg 1967581 tatacagcat tcacaccata agccatgaac atccggcaga tggccacgcc tgctgcgcca 1967641 aggccgattt gccccacttt cgcttccttc aggtcaaccc ccgcactcct gcatgccgaa 1967701 atggcagctg ccagcgtcac tacagctgta ccatgctggt catcgtgcat aacagggatg 1967761 ttcagctcct cttttaggcg atcctcgatt tcaaaacaat gcggcgaacc gatatcctca 1967821 agaaggatgc cgctaaagcc cggagaaata tgttttactg ttttgatgat ttcttcagga 1967881 tcactcgtat caagcagtat cggaatgccg ctaatacccg ccagctgatc aaataaagca 1967941 gcctttcctt ccatgacagg catgccagcc acagagccga tattcccaag gcctaaaatt 1968001 gcggttccat ccgttacaat tgcaacagaa ttgctgatcg ttgtataaat agaagctttt 1968061 tcaggttctt tttcgatcag tcggcacacg tccgcaacac ctggtgtgta gacacgtccc 1968121 agctctgcca gtgaacggat cggcattttg cttttcattt ggatttttcc gccttcatgt 1968181 gcggacagga cttcatcaga tacggtgtga agcctgatcc cttctccgag ggcctgtaca 1968241 gccgcgatca cttcctgaag ctgttcttca ttctccactt gaacggtaat attccgcatt 1968301 gtgtaattgg gtccgacttt taccgtctcc acttcaccaa tatccccgcc cagaaggccg 1968361 atggccgtag ccacccttcc aagatttccg ggaaccgaag gcgtttcgat catcagtgtc 1968421 cgaatcatgt gtttcgctat cattcagtga tcctccccta ttagcctagt ttttcggctt 1968481 taactgtatt gtttttcgta taccatataa attttcctgt ataaccatag ataattgcaa 1968541 gacctattgc tacaaaactg agccacataa acggcagata agagaaggta gaaacaccta 1968601 aaataccagc catgtaaatc ccattatcag accaaggaac catccccgaa gtcaatgttc 1968661 ccccgacctc tgagttacgt gataacactc ttctgtccag atgtaagcga tcatagctgt 1968721 cttccataat tttcggagtc aaaataagag atacatacat cgcacagccg aagatgtttg 1968781 ctaaaaacgc tacgatcagt gtagacaatg tgacattgcc ggctgaagtt aatttctttt 1968841 caaacgttga aacaatgact tttaacacgc cgagtttctc aagcagaccg ccaaaaccaa 1968901 ggccaaagat gatgacgacg agagaatcaa gcataccgac aattccaccg cggtttaaca 1968961 agccgttcaa aaattcaaca tccgttttaa tagagaagcc gttgtacgca gttgcaatcg 1969021 catgggcaat atccattcct tggaaaacaa cagcccagat tgcaccgagt aaagcgccaa 1969081 ttacgataac tggcatagat ggctttttca tcgccaataa gactatgacg agaactgccg 1969141 ggatcagcat ccaaatatga atgtcaaacg tgttttgcaa agatgatttt aagaattcaa 1969201 ctttatcaag atcaatattt ttcccgccgt acataaatcc aacaactgta aagagtatag 1969261 ctgtaatgac ataagcaggt attgataaat aaagcattgc tctcacgtga gccaatacat 1969321 cgacttttga tagtgaagaa gctagaactg tactgtcaga cagcggagac agcttgtccc 1969381 caaaataagc acctgaaaga atagctcccg ctactagagg aagcggaatg cctaacccct 1969441 ctccaattgc gatcatggca atgccggcag ttccgactgt tccccatgac gttcctgttg 1969501 ccacagacat aatggaacaa ataattaacg ttgccagtaa aaagatactt gggtgaataa 1969561 attccagtcc gtaataaatc aaagtcggca caacgcctcc ggcaatccat gttccgatga 1969621 gcgccccaac tgaaacgaga atcagtacgg cttcaaggcc atttgatatc ccatgtacaa 1969681 tcgcattttg taaatcttta taagaataac cgagtctaat acctaaaagc attgcaataa 1969741 accatgaaac aaaaagcgcc agctgtatcg gcaagtcgag aaagactgta aacgatagaa 1969801 caagtgctaa aaatactcct agtacaataa taatttcaaa tagtgttggc aatcttacat 1969861 ccttcaaaag aagtccccct tcatgtaaaa gctaaaacgc tttcaatata tagtgcaaca 1969921 cgtatactat acttcctcat ccctatgttg taaacagctt attcatccga ctattcggag 1969981 atgaataagc tgtattttat acaaatttta tttttctaat agttctttcc ctgcgatacc 1970041 tggtttggtc atctcatatg ggtttaaaat aatatccaat tcttcttcag tcagcacatc 1970101 atgctgcaga caaagatccc ggacagattg ccctgtcata attgcttccc tggcaattct 1970161 agctgccgct tcatacccaa gatgcggatt gacagctgtg atcacgcctg cgcttttttc 1970221 tacgtattgc ttcatacgct tttcgttggc ttcaatgcct tttaagcagt tgtcagtgaa 1970281 cgaacggaag ccgttgttca tgatgctgat ggattgaagc aaattaaaga caagcacggg 1970341 ctccatgacg ttcaactcaa gctggccggc ttctgaagca aggcagattg tattgtcatt 1970401 tccgataacc tggaacgcaa tttggttgat cagctccgcc ataaccggat tgactttccc 1970461 cggcataata gatgaacccg gctgacgtgc aggcagagaa atttccgcaa gtccggcgcg 1970521 cggtcccgac gccattaagc gcaggtcgtt tgcgatcttc gacatgttca tcatgcagac 1970581 ttttaatgaa gctgatacct ctgtataggc atctgtattt tgtgtcgcat caacaagatg 1970641 atcagcgccg acaagaggaa gcccgctaat atcagcaagg tgctttacta cctgtttgat 1970701 atattcagga tcagcgttca gccctgtacc aacagcagtt gcgcccatgt tgacttcata 1970761 caggtgctgg cgcgattgct tgattcgttt gatatcacgc tcgagaacac ggctgtaagc 1970821 ttcgaattcc tggccaagac ggatcggaac cgcatcttga aggtgtgtcc ggcccatttt 1970881 aataacagag tcaaactcct gtgctttttg cttaaacaca ctatgcatat cttccattgt 1970941 tttcagcagt ttttctaaga gcttcaatgt ggaaatatgg atagcagtcg ggaacacatc 1971001 gttcgtagac tgtgacatgt tcacatgtgt gtttggactt aaatggatat aatctccctt 1971061 tttatgtccc atgatttcaa gcgcccggtt tccgataacc tcattcgcgt tcatgttcat 1971121 agaagttccg gcaccgccct gaatcggatc gacgataaac tgatcgtgcc acttgccttc 1971181 cagaatctcg tcagcggctt gtacgatagc ttggccaatt ccttcataca gccgtttcac 1971241 gtccatgttg gcaagagccg cagctttttt cacaatcgcc agtgcgttaa tcatttcctc 1971301 atggattttg tatcctgtga tcggaaaatt ttcagaagca cggagcgtct gaattccgta 1971361 ataaacatct gcttcaattt gtttttcccc aaggaagtct ttttccacgc gatattcttt 1971421 ttggccgttt aacataatct ttaaccttct ttctctttgc tggttatcgt ttttacattt 1971481 tacaggacaa cgtcatcagc tatcggcgtt tccataattc tcttgacgac aggaagatcc 1971541 gaagactgac ctagcgccca catcaatttt ggcacaattg cttctgtgtt catatttctt 1971601 gatcggataa ttaagtcttg gttgactctg cggccaacct cgtaaatgct catgtcttcg 1971661 ccttcttcaa gacattgagt cgtaatgacg acgacaatgc cgctttcgat cagttcattc 1971721 acttttgaca aaatgtctct gccttcaaac ggcactcctc cgctgccata actctcaatg 1971781 acaattcctt tgtacatgct tttcagggca tcaaacattt cgggctttaa gcctggatgc 1971841 agcttcagca gacatacatc tgtgcatagt gaagtgtcaa ctgtgaaggt gtcgttctca 1971901 ggttccgtta cttgtttgtt gtattcgatc ccgtcttcat tgataaaagc gatatatggg 1971961 taattgatgc tttcaaatgc gtcgtagctt ttcgttctta atttgatcgc acgcgttccc 1972021 tgaatgactc tgccgtcaaa cacaacataa acgccgccca cgccttcaca ggcaaatcga 1972081 atggcatctg taatattttt tttggcatcg gttttttgga acgtgatcgg aatctgcgag 1972141 ccggtgatga caatcggctt tttggcatgc tgcagcatat acgatagtgc ggcagatgta 1972201 taggccattg tatctgtacc gtgagtaata acaaacccgt cataggcatc ataattttcc 1972261 ttaacggctt ctgctatttc cacccagtat tcaggctgca tattggtgct gtctatattc 1972321 ataagcgact gagtttccat tgtgtaatcg ttatcaagtt ttgatacgta acttaataat 1972381 tcatcagcct tgactccggg agccagccca ttttcccctt caactgaagc aatcgttccc 1972441 ccagttgtca acatcaataa ttttttcata ccatgcacct cttcactgta tctaaagatg 1972501 ggttgcgaga aggtattcgc ttttcgcata cttttaatgc aattatagac acggaaaata 1972561 aaatacgcaa gacattatta ttcaattcgc gtacacttcc taatacctat atgatataat 1972621 cagctcaagg tgaaaaagga gcggaagttc atgaatctag atcgtttaac tgaattgaga 1972681 aaaaagaaaa attggtcgct tcaatataca gctgaccttc tcggtatcgc aaaaagcaca 1972741 tatgccggct acgagtcagg ctaccgacgg ccttcacttg aagcgcttgc catgctggct 1972801 gacctctttg acacaacctg cgatgaactt ttaggccgcg agaaacaaaa gcagactgct 1972861 cctcaggcca tagaattggc cacgtggagc agcctcgact ttaccatttc tgttgatggc 1972921 cagccgctga gtgaagatga aatcatccag ctgattacct ttatacgcac aaaaagaaaa 1972981 gtacaggagg aactgagtta atctttagct cacggtttaa ttttaccgta ggttcctcct 1973041 cctccggctt tcaattccag ttttccggat ctcgctttta cgataagcgc cgcggttttc 1973101 ggcgggacaa cgcgagccaa atcttcttct gcagcctcat gaagaacagc catttctgtt 1973161 ccgaaggctt tttttagttt gtccagcgtt ttcgggccta cacccggaac aaattgcagc 1973221 gggatctgat gtacatatcg cggacgcggg acgcgaactt caagctgatc actcaattca 1973281 cgcaatctat cgctgactcc cttggtaaat ctggcttttc cgcaattcgc gcacgctgtt 1973341 tccccgctta cagcaggctc tccgcacgct tcgcaagccg tctgataata tttccccaat 1973401 aacgggtcca agccataatt tgcgataatt ttcctgtcat cttgtccctt taatgcaaga 1973461 gcaaattcag taaaatcagc tgactgcaca tataattcat tatattctct gccgattttc 1973521 cccaacgaat gcgcatcaga atttgttaaa aaaggatacg gattcaattg cgatacgtgt 1973581 gatgccatgt ctgtatcaca gcttaatcca agctccaccg cgtctatcat agatggatca 1973641 aaaacctcag ttaagcttga tttaacccct tttccatata agcttttatg cggcgtaaag 1973701 atatgggcgg ggataaacag gccgcccata tcctgcactt ttttttgcag gtttaagccc 1973761 gtttcataaa tccgctgcga gcttaaatga atatttttca gccgggctga cagccagttt 1973821 gaaaactgtt tcatatcagc cagcgtcggc ataaatacga gcacatggat cggtccgctg 1973881 caggcttcat cataaatctc cagctcgctc cccaataaaa gagtcgtgct gcgataacgg 1973941 attcctcccc cgtcaagctc gcgatatttt ccagatgaaa tgccttcctc aagctctaga 1974001 atgacttccg gagaatgaca gtcgataatg ccgaggagtt caattccttt atgttcactg 1974061 gcttcaacca aaattctgtc cagcgttaat gttttggcgc ctgttatttt gacagccctt 1974121 cctgtaaagg tccggccgat atgaatgtgc aaatccgcgt aaatcttttt catttttgtg 1974181 cttggagcgc ttctttcagc tgaagatact gaatcgcgta ggctgtttta gcatcatata 1974241 cttcacgcga ttcaaccagc tttagcgcat cttcaagcgt cacctccatc acttcaacaa 1974301 actcgtcctc atcaagctcc cgtttttctt caagcacaga aagctcctca gcaagaaaaa 1974361 cgtgaacgat ttcatctgca aatccgggtg atgtataaaa cgcagttatt tttgtcagtt 1974421 tttttgctgt ataaccggtt tcctcttcaa gttcccgaag tgccgtatac tccggctcct 1974481 cacctttttc aagcttaccg gccggaattt caacgatcgt ccgctcaagc ggcttacgga 1974541 attgtttgac catgatgatt ttcccttcat ctgtgacggc tagtaccgct acagctccag 1974601 ggtgtttcac aatttcacgt ttactggctt tgccgtttgg cagctctaca tcctcgacat 1974661 aaagatcaat gactttaccc gaaaaaatct gttctttggc aattgttttt tcttctaatg 1974721 atttcatttc ttcatctccc gttctgtctc tatatgatgc cccatacatt ttatcatact 1974781 agagcaaaag ggggcttctt cgtgaaagtg caccgcatgc caaaaggtgt tgtcttagtc 1974841 ggaaaagcat gggaaattcg agcgaagtta aaagagtatg gacgcacatt tcaatatgtg 1974901 aaagattgga tctcaaagcc ataaaagttg aaactttagc tcctttatat tacggtcaat 1974961 acaaagccta aaaaaggagt gtgcacatga gaaagcgcaa attgggtaca tctgatttag 1975021 acattagcga agtcggactc ggctgtatgt ctcttggaac tgaaaaaaac aaagcattgt 1975081 ccattctgga tgaagcgatc gagcttggca tcaactattt ggacacagcg gatttgtatg 1975141 accggggacg caatgaagaa attgtcggtg atgcgatcca aaacagacgc catgatatta 1975201 ttctggcaac aaaagcggga aaccgttggg atgacggaag cgagggctgg tattgggacc 1975261 cttcaaaagc ttacataaaa gaggcggtaa aaaagagcct tacacgtctg aaaacagatt 1975321 atatcgacct ttatcagctc cacggcggca cgatagagga caacattgat gaaacgattg 1975381 aagcgtttga ggaattaaaa caagaaggtg tcatccgcta ctacggcatt tcttccatcc 1975441 gcccgaatgt gattaaagaa tatgtaaaaa aatcaaacat cgtcagcatt atgatgcaat 1975501 tcagcctgtt tgacagacgc cctgaggaat ggctcccgct tttagaggaa catcaaatca 1975561 gcgtagtcgc cagaggtcct gttgccaaag ggctcttaac tgaaaaaccg cttgatcaag 1975621 cttcagaaag tatgaaacaa aacgggtact tgtcctattc attcgaggaa ctgacaaatg 1975681 cccgtaaggc aatggaggaa gtggctcccg atctttccat gacagaaaag tcgctgcagt 1975741 atctgctagc acagccggct gtcgcttcag tgattacagg cgccagtaag attgagcagt 1975801 tacgggaaaa tattcaggca gcaaatgcac ggcgtttaac cgaagaggaa atcaaagcgc 1975861 tccaatctca tacgaaacaa gacatttaca aagctcatcg ctcatagcag aaaaaccagc 1975921 acctgtacgg gtgctggttt atttatattg atgccaatcc atttggcttt catttaggag 1975981 ttcttcaaag ctcttatttt tttcgatctc ttttttcttt ctaatctgtt ctgctttttc 1976041 tcttttctgc ctcttttcat cctcttcctt caattggctc ttcatctcca taagctttgc 1976101 tttgatatcg gattgaaggc cgtcttttag ctggtgtttg tcaatggatt tttgtttttt 1976161 catgcagact tcccccatgt tttgttttga agccagttta tcacggagca tataaactga 1976221 acaagcagac tctcttctga tcactttctc agcgtagcag tgtttaggta taatgatctt 1976281 aaacacgaat tgcctatata tttcgttgaa aggtgctgtg acttttgaag aaaatccttt 1976341 tggccattgg cgcgctcgta acagctgtca tcgcaatcgg aattgttttt tcacatatga 1976401 ttctattcat caagaaaaaa acggatgaag acattatcaa aagagagaca gacaacggac 1976461 atgatgtgtt tgaatcattt gaacaaatgg agaaaaccgc ttttgtgata ccctccgctt 1976521 acgggtacga cataaaagga taccatgtcg caccgcatga cacaccaaat accatcatca 1976581 tctgccacgg ggtgacgatg aatgtactga attctcttaa gtatatgcat ttatttctag 1976641 atctcggctg gaatgtgctc atttatgacc atcgccggca tggccaaagc ggcggaaaga 1976701 cgaccagcta cgggttttac gaaaaggatg atctcaataa ggttgtcagc ttgctcaaaa 1976761 acaaaacaaa tcatcgcgga ttgatcggaa ttcatggtga gtcgatgggg gccgtgaccg 1976821 ccctgcttta tgctggtgca cactgcagcg atggcgctga tttttatatt gccgattgtc 1976881 cgttcgcatg ttttgatgaa cagcttgcct atcggctgag agcggaatac aggctcccgt 1976941 cttggcccct gcttcctatc gccgacttct ttttgaagct gaggggaggc tatcgcgcac 1977001 gtgaagtatc tccgcttgct gtcattgata aaattgaaaa gccggtcctc tttattcaca 1977061 gtaaggatga tgactacatt cctgtttctt caaccgagcg gctttatgaa aagaaacgcg 1977121 gtccgaaagc gctgtacatt gccgagaacg gtgaacacgc catgtcatat accaaaaatc 1977181 ggcatacgta ccgaaaaaca gtgcaggagt ttttagacaa catgaatgat tcaacagaat 1977241 aaaaaagcga aaggcctctt cggctctttc gcttttttat gttacagaac gtcggtaatg 1977301 ccatccatat tttctctgat ccattcaatc gcaagatcta tcgttgtaaa ctcctgcgtc 1977361 tcgaaggtca tttcatcctg caatagccag acatctttct tgatggactc tgctcctccg 1977421 attgaccagt gaagcaaggt ataaggatgg ttttgattca ggaaggatac ccacgtttta 1977481 ttttgtgctg tgttcttcat tgccttcagc ttttgttcca cgtttcgcgt ctcctacttt 1977541 actaatatgc tcattctggg gctgagcatt tcagccgggc ttttcagcgc caatgttttg 1977601 gctttttcat tgtaatcgat cgtcatttga tcgtcaaaaa acactttttg cgacgattgg 1977661 atatacagcg gaatgccgtt cgtttccagc tgctcgcact gtcccgttaa ttcttctgcc 1977721 agccagattg tcgggacacc gcttaccgcg cagccgcatc cttctgcatc gtaacgaagc 1977781 tgggcttttt ttcccgggtt ggcgtcaaac gcctgctgca gtgcctgttt tgctgcatct 1977841 gtcacatgta tgttcataag gtgaaacccc cgttttcatc attttcgcta ttgtagcata 1977901 caatactgcc attcgcattg tttctgcctt ttttccaccg cttcgcattt tcttctgcag 1977961 tcttgatcca ctcatctttc ccttgtatat actgattgat gctgtcaggg tgctgggccg 1978021 ccagctgttt tttgagaacg gcgtattctt tcgctatgtt tggatgagct ctgagataat 1978081 ctctgaataa cagatgcctt tcaatagcag ggtttccctg ttcgtacata tggacatgat 1978141 gagtgcgttt atttccgccc ttttggaaat aacgcctgcc cgctataccg ttctcacctt 1978201 ttggtgtata gccgttggcc ttcatttgtt catcaaattg gctcacggct tcaatgcttc 1978261 tgacttcaat taacatatca atgattggct tcgctgccat gttaggtatt gatgtgcttc 1978321 cgatgtgatg aatagcgata atctccggcc cgaacacaag tttcagccgt tctttttctt 1978381 catcgaaaca ttctgcccat ttttcgttgt agagaatgat ctcaactttt cttttcggat 1978441 acaaatgaaa gaccgacagc aatagaccct gcgctgcttt gacggtttct gccttttgga 1978501 atccggcctg tgtatagagt gacacagccg gggtattgtt ctcggctgtg actacttcga 1978561 ttttctcagc gtcttcatta tgatcaatga caaattgcag aagcgctcgt ccaattcctt 1978621 ttctgaaacc gtcaggatgc acaacaagcc tgcaaatggt gagataatgc atgtttttct 1978681 catatgaaat gacaccgatc agcttgccgt ttttccgata tcccgcaaac cgttcatggg 1978741 atgcttgaat atcctttacc ttctcttgta aagcgggaat accgtcaaaa ccgataatct 1978801 ctgtttcctt tatgtaggcg gggatctgta cggctaaaat ctcacgcgct atagtggctt 1978861 ccttatgctg gagaaattca atcattcgtg ttctcctgaa acagccgctg tctgtcgact 1978921 tttgcgacgc ggactgcata cgactcgtac caaacgcttc ttcctttttc ttttgctgct 1978981 tgatgttcag tgtgatgcct ccaatggtta attgcgtcca tactgtccca ataggaaact 1979041 gtgatgcccc ttccatccgc ttcacgtacg ctttccacgc ctaaaaatcc aggctgatcc 1979101 gccgcaagtg ataccatccg ctccgctgtt tctccatatc ctgtgtcatt ttcgcttttg 1979161 acagaagaaa aaatgactgc atagtaagga ggctcaggtg tttttgataa aaaatccatc 1979221 atatttcccc ctcatatgtt tttgacaaat agtaccctgt cttggcccgg gccatcatag 1979281 tttgcaaaca ctgagatgcc atttaccgtt ttggtgccct tttcaatatc aaaccccaat 1979341 tttgtgtgat atgcgattga taccttattc acaggtgaag tgacacactt cacccgggtg 1979401 cagccccttt gttttactgt ttcgataaat acatcataca attgtttccc aatttgcatt 1979461 tttctgaaat ccggatgcac accggaaaaa tgaatgtacg ccgtttcagg atcggattgc 1979521 gattgaaatc cgattaaaaa tcccgtcatg ctgttatgtt cggatgtaat aaagcttgtg 1979581 tcctgaaaat gctcaaaaaa tagtctcggc aatttttctt tcagctgtct gccgccccac 1979641 cattcattca gtacagacgt taccatttca taatctgaag acgtgattgt tcgaatatcc 1979701 attacgattt gatctccctc cgtctggcaa aacgaatgtc agctcttttt ctcacaatat 1979761 aaaaattata ttttgcctgg ctggaattgt aaatgccttc tttcctgtat catacgtttc 1979821 cagactgccg agggaacaat gtttgatcat tttacgccta tttctccccc aaacaggagg 1979881 agagacttta cagcacaata tcaagcactt gatcaagttt cagcttataa agctgatcct 1979941 cgtctccttt tatccatact gctttttcaa actcttcata ccggcagatt ttcccggtgc 1980001 agcagacaat ctcaccgtcc tgaaagcagc tgacagtgat atcctgagca aactccatcg 1980061 cggcgcaaag cgtttgattc atctcttcca gcttatcggg gtcaaggatc ggcttttgca 1980121 gcttctgttt aagtcgcttt ctctccagca ggctttgctt atgttccggc agaaacatcc 1980181 tgctcccttc ccacagcagg ttgccccttt ttaaatggtc gttcatttat aatgcccccc 1980241 tattttagcc gcacgttcaa atgcctggcc tgccgctgtc agtgacgccg ccctgatgat 1980301 tgctgtatcg ccgaatcgat ttttaatgcc atccatcaca tagcctaggc tcattttctt 1980361 tgcataatcc tgaaataaat tgagctgcca tatgtcatca gatgagagct gagacagatt 1980421 gacaccgagg cggcggacgg gtttcccgtc ccaaaatgta agaaacagcc gtcgtacagc 1980481 ctcatataca tcctgcgtag aattagtcgg ctctgccagc ttcacttgcc ggttgaagcc 1980541 cgtcggccaa tcaaaatcag caccccggca gctcactgac actgtctgcc ccatgacccc 1980601 ggcgtttcgg cttcgcctgc acacctcttc actcagctca agcaatacga ccttgatttc 1980661 tttgtcaaag tgttcgtagt ctctcgggag agtcattcca tgacctatcg ccttttgccc 1980721 gtccagagac gaagttgaca caggggaata gtcgattccg tttgccgtca tccacagcac 1980781 gtggccgtta atgccccatt tcttttttaa aagatcgagc ggaaaagccg cgagcccgcc 1980841 gatcgtgctg atgcccattc gatttaaatg atgcttcatg cggctcccga cgccaaacat 1980901 gctgcccacc gggagcggcc acatttcggt tttcatattt tctttcgtta aggtaaaaat 1980961 accgttctta ttctttttgg caaaattgtc acacgcaatt ttggccagcg ctttgttagg 1981021 gccgattccg acccgtgcat aaacgccgat ctcccgcatg attctgccct gaatgctttt 1981081 cgcgatctcc atcggcgtcc caaacagctt ctggctgcct gtaatgtcca tgaactgttc 1981141 atcgatggaa tacggctcca caaggtctgt atactcctcg agaatggccg taatttgcag 1981201 tgatacatca atataccgct gcatacgcgg ccggagcaca acagcctcag gacacttttc 1981261 ctgcgcctcc cacagccgtg aagcattcac cacacccttt tgtttcgcca gcgggcaggc 1981321 agccaatacg actccgcccc ttttttcagg gtcacccgaa acaatgacgg gcctattttt 1981381 caaatgtgga ttttccgctt tctctacaga tgcataaaac gattgcatgt caacgagaaa 1981441 aatcactttt tctttcatca tacacacctc taaaaagaac ttatgttcgc ttttcattat 1981501 atgcgaaagt atgttcgttt tatactggta aatgattctt gtctgacaga aaatatgatc 1981561 caagggtttg agagaagaaa aacatttagt agaataaaag cgaagcataa ggataggaga 1981621 gtcatgatgg agaaatttgt cgaaaaaatg ctgggacagg cattgcggca atacggcaga 1981681 aacgttgcta tagatccgtt aagcccgtat gaaaaacaaa gcctgaaagc ggctctacaa 1981741 gagagacgga atgaagaacc agatgaggat ttgcatgcgc atatagaaga tatcatttat 1981801 gactatgtca caaaccaagg cctgttctct taaacgcatg actgtcagtt ctttcagccg 1981861 ctgatgcggc ttccctttga aaacaccgcc tgaaacaaat aaacagtctc aggcttacag 1981921 aaaaaaagca ggattttctc acgctccata gattcatatg gcctggcgta aaattcccct 1981981 caatgctcgc gcaaaacgga ataagctgtc catgatcacg cgtatacact ttttcgaaga 1982041 gatgtgctct cttgttctgt catgcggtcc atgccggttt tcagcgtaca tcttgatctc 1982101 atagccggtt tcactgccga tatgatccac gttctggcgg cttaaactaa cacaccctca 1982161 ctgaccaatc gctttgcttt tcatcggaca tcccgtcatt ttccttcttt caagatgtaa 1982221 actccgtcag ccacacgcat cctcaacgca tagtatattg ccatccatac aatcaggcat 1982281 actacatgtc aataacgaaa tattttgaac gatctattgg agaaggaaat tttttcatat 1982341 atgatagaga aagatcatac atacaggaga gaatataatt catgaagaaa tggaaagata 1982401 tccacccgat cagctggaca attataatcg gaaccatttt cggcagaatg gcaacatcga 1982461 tgagcattcc ttttttagcg atttatttga cagccgtcca aggcgcatca gcttcctatg 1982521 cagggctggt catcgccgcg agctcatcag tcggcatcct cgcaagcttt tacggcggat 1982581 atatctcaga taaattcggc agaaaaaaca tgatgcttgt atcgattttc ggatggatgc 1982641 tggtatttgc aggctttgcg gcagcatcta atctctgggt gttttttgta gtaaacgcat 1982701 taaacggtct ttgcaaatca ctgtttgagc ccgcttcaaa ggccttgttg tctgatatga 1982761 cagaagaaaa aacgagactg ctagttttta atttacgcta tgcggctatt aatatcggcg 1982821 ttgtcttcgg acctgtgctt ggcctatatt tcggctcatc gcaatcgact acgccctttt 1982881 tggtgcctgc agtcatttac ggactatacg gaattgtgct tgccctccaa tttaaaaaac 1982941 atccatcctt atcagcacca gcccagtccc gaaatatgag cgtgcgggaa gcgtttatgg 1983001 tcacgcaaaa ggattatctt tttaccattg ctttggtcgg cattacgcta tgcaccttcg 1983061 gctactcaca attcagttcc acattccctc agtatatggc gcagaacccc ttgatcggca 1983121 atggaacgaa gctgtatggg ctgatgctga cattaaacgc aatcgttgtg ttggcgacgc 1983181 aatttcccat tgtccatttt gcaaaacggt tttcgccgct ttgttctctg atgctcggta 1983241 atgtgatggt tagcatcagc atggccattt tcaccgtatc acacggtgtt ccatcaattg 1983301 tgatgattgt catcacattt acaatcggcg aagtgctttt attctctatg atggatttgt 1983361 atgtagacca gattgcaaaa ccaggattaa aaggcactta tttcggggca atcggttttt 1983421 cacagctcgg aaacgtcatc ggcccttggg tcggggggat atgtatagac ctgtttggcg 1983481 ctggccggcc gatttatatt ttttctgtcc tgagcggcat taccctgctc ggcctgccat 1983541 ttttagcgtt cgcctatcgg caaatgaaaa tggagaccac aaaacaccgt tcccgtctgg 1983601 aaaagccgct ttaaataaaa aacggaagag aatgaatctc tcccgcaaac atgaggtgaa 1983661 gaacatgaat ataggtgatg tgatgtttca gctgtttgta tttattatat ttgccgctgt 1983721 cgtctttgcg gctgttacag gcttcaagta tgcgaaaaac cgaaaagcgc agctggatcg 1983781 cattgagaaa aagctgaaca gcctgtccga agatcacgat taacagcttg gggcaacgag 1983841 ctctacctta atccggtctg gatcctcaca aaagactgca taatgcccgt ctcctccggc 1983901 aaaaggatgc ctgtctcggt acaacacacg atagcctttt gccgtcaatt tttcagtcat 1983961 ctgatcgact tgaagcttgg attcagcatg aaatgcgaga tggttcagac cgactcggca 1984021 tctatggtat tccggctcta gaaatggctc tttcgcctgc acaatcacta ggtaaaaacg 1984081 atctttcttc cagctgatgc ctgagctcca tttttgatac tctttataac caagttcttt 1984141 taagaaccag ccccaaaacc gcctagacgc ctccaaatca gagacataca gttcaatatg 1984201 atgcacattt cataccctcc ttaccaacac ttcctcgacc ttatgcccgt ctcccttacg 1984261 caaaatgaga tctgacctga atttagttgg caaaatattt tcatataaat tcggccggtt 1984321 gacactctcc caaatcgagg ctgccatctc gtcagcctcc tgatcggaca agtctttaaa 1984381 tttatgaaaa tatgaatcag gattttgaaa agctgtttcc cgaagcaggc gaaaacgctc 1984441 taaataccaa gtgaaaatcc ggctttcctc cgcatccaca taaatcgaaa aatcaaagaa 1984501 atcggaaaca aaaatacgcg ggttttcccg gtcatcctcc aaggtgggcg actgaagaac 1984561 attaatgcct tcaataatca caatatccgc ctgttctaca acctcgaaca caccttcctc 1984621 gcggtcatag gttagatggg aatacaccgg ggcctttacg ctgtcctttc ctgattttaa 1984681 gtcattcaaa aattcgagca gcgcctttac atcatagctt tcaggaaatc cttttcttga 1984741 catcatattt ttctttttca gctcggcagt aggaaataaa aaaccatctg tcgtgataag 1984801 gctcactttt ggacggtcag gcaaacgcga aagcagcttc tgcaagatcc gcgccgtcgt 1984861 gctttttccg actgcgacac tgccggcaat gccgataata aacggaattt tggctgaatg 1984921 tgggtgcttc aaaaaaacat tgacatgctt attgcgttca gccgcagact tgacatgtaa 1984981 atgaagcaag cgaacaagcg gaatatagat cgtctccact tcttcaacag atagataatc 1985041 attcaatcct tccacagctt ttgcctcttc ttcagataca gcaatcgaca aatgcccccc 1985101 aaaaccagac caagactccc gattgtgctg tgtatataaa gtatgtaggt taagttcttt 1985161 atttttcact gtttacacct gactctctgt aggttaaaac ccttacaaag attgtaacgg 1985221 aaaacctttt cactgtctgc ttatttttca tttcgttttt ttagcaaatc agcaccgatt 1985281 cggttatacg cagccatttc atcttttgga accatgcttc ctcccgttcc ccagacgaca 1985341 tgtacggcat gttccatctt atatttctga gcatagcgcc ttccctcttc tgtcgaaaaa 1985401 agctgaaccg gcccgaacat gccagcaaga gcagagggct ctaaatattt atcttcagat 1985461 acagccagca tatgaagcaa agtataaagc gtattgtcct ctaccgtata acagccgctc 1985521 agaagcggtt caatcagctt gccgacaaat cctgacggcc tccctacggc aagtccgtca 1985581 gcagccgtct gattatccag gccgatatcc tggacggaga tcttctcgtg aagtcctgaa 1985641 taaagcccta acagcataca aggtgaatga gttggttctg cgaaaaacac atgaacatca 1985701 tctccgtata aaagcttcag cccaaatgct acaccgcccg gtcctccgcc gactccgcac 1985761 ggcagataca caaacaaggg cgtctcaaga cttggcttta tattcataca gtcaagctgt 1985821 gtttttaatc ggcttgcagc aacagcatat cctaagaaca gctgacgaga atgttcatca 1985881 tcaataaaat aacagaatgg atcttgttcc gcctgccgtc tcccttcgtt caccgcttca 1985941 ctgtaatctg tttcgtactc cataacagtg actccctttt ggcggaggag atcctttttc 1986001 cactgcttag catcggcgga catatgcact gtcacgcgaa acccgagtgc cgcgccgatg 1986061 atgccgatgc ttaaacctag atttcctgtc gaaccgacag caatcgaata gcgggagaaa 1986121 aacccggtaa accgctcttc ctgtaagatg cggtaatcat cggtttcctg aagcattcct 1986181 tcttgaagcg cgagattttc agcatacttt aacacttcat aaatcccgcc cctcgcttta 1986241 atcgatcctg aaatcggaag ctcatggtcg cactttaaaa gccatcttcc gggaaatggc 1986301 tgctgatatg ccgcttccag ctttcccttc atatgctgca cctcaaaaag cggagactcg 1986361 atgattcctt tagcgccttt cgtctcagga aacacctcgg caatgtaagg tgcaaaccgc 1986421 tgcattcttt tttccgcttc cgctatctcg gttgcccact catctgcacg gggtaatggc 1986481 ccctctttct tgcctgaatt tgcccagaat acaggctctg catcaatcag tttctgaata 1986541 aacggatctt taagcagagc atgaaggact tctgaatgaa ctgacattca acaatctctc 1986601 ccttccacta tcaaaaactg ccccgtgaga aacaagccac tccaccacag gcagttctat 1986661 cattattttt tcatgagcgc gcgtcctgcc agcttttcta caagagctgg aaacagctga 1986721 tacagcttag tgccggcatt cattaaacgc ggaagattga tctcccgctt tttcgtaaaa 1986781 attgcagctg taatttgagc tgccacgtca tcaggatcaa gcatccagcg gccgacattt 1986841 ttggcgtagt ccccgccttt atcagcaatg gaaaaaaagt ccgtctgaat cgggcccggg 1986901 ttgactgttg tcacataaat gccggttccc gaaagctcca tccgcaaagc gtttgagtaa 1986961 cctaacacgg catgtttggt cgcggaatac aggctagact tcggtgtggc gattttcccc 1987021 gcttgagagg cgatattgat gatatgtccc tttttttgct caagcatttg cggaagcacc 1987081 gcttttgtac aggcgatcag gccgaagaca ttcacatcaa acatcgcttt catgtcatcc 1987141 aatgtagagt ctaaaaccgt ttcaaatata ccgaagcctg cattgttaat cagtacatca 1987201 atcgagccga tctgatcgcg gacccgggcg atatcctcta ggcggccgac atccagagga 1987261 aaaatctcac actgtccgct ccattcctcg gttattttcc ttttgatttc tatcaaacga 1987321 tcctcgcgtc tagccgacag caggacatgg gctccttcag ccgcgcataa gtatgcgatt 1987381 ctttctccaa gccctcctga agcgccggtt atccaaatcc tttttcccgc tatatgtttc 1987441 acccatttca cctcttcatt gttttaaagt atacggtatt tccttcccaa tatgacgtga 1987501 tggcttcttc agcctccaac acatcaaggt gacctgccgt ttctgacatc gttaaaaaca 1987561 attccttttc atatacagca ggaaaaagct gctgacagac ctgaaaagcg gtcatcggct 1987621 tttcatccag catgcgacgc acatcctccg tcctgttcct ctgcttgtca aaacgcttct 1987681 caatcagcgc ttgtacactg gtgataggct cgccgtgacc aggaaatacg attgttggat 1987741 caagttgaga cagccttcgc aatgaccgct gataatccac taaaggcttt gacctgacgt 1987801 ctcccgcttt cggcgcttcc aaaatcggat tagacgagct gtttgccagc agtagatcgc 1987861 cgccaagcat ccttccgctt ttttcatgga acagaacaat atgcgattca gcatgtccag 1987921 gcatctccaa cacagaccag ccctcaagcc catctatgcc cataccttct ctgattgatt 1987981 ttgtcagaga tctcgtacag gaaaatgcgt acgctgatcg aatcagcttt tccgccttcc 1988041 ccgtatcaaa tggaacgcct aattcaggca gcagcttttg aaaaaaacgt ttttgccaat 1988101 ccataaaggc ttgattttgg ctgatataag gttcgttgaa tgtatgccca atcacttcga 1988161 tttcatctga aaagacatca agcaagcctg catgatcagc atgatggtga gtcagtacaa 1988221 cctgctcgat atctgacaat ttcacattta cagcggcaag ctgctcttgt aaggctctgg 1988281 cagcctcttt tgtattcggc ccggcatcga taagtgtcag cgcatcacct tttacgaggt 1988341 aaacgataac atcgccgaca gcaaacggtg tcgggacgcg gatcgcaatt acatcttcag 1988401 ttgtcatcct ttcgctcctt gtcttcattc attattcata ttttagcttt ttctcggtct 1988461 tgtgtcatta ttgcagaatg agaacaaacc tttttgaaaa agctattgac attagcttgt 1988521 ccgccattgc ataatgaaca acaaactaaa acgagaacca ttggaacgct atgacgagga 1988581 atagtataca aggcaatggc ctaagagagc gatacccccg gctgaaaggt gttgcggccc 1988641 gcttgtttgt agaacctgcc ctcaagtcgc ggttaggaaa acctaaacgt ttcccgcgtt 1988701 acggggattt gagctgagca caatttgtgc taatgagggt ggtaccgcga accttttcgt 1988761 cctttacgtg atgaaaaggt tttttgttgt tctaatagaa ggaggatatc aatgaaaaag 1988821 ataggatttg tcggcgccgg gtcaatggca gaagcaatga tcaacggcat tttgcaaagc 1988881 ggcatcacaa aaccagaaca tatctatatt acaaatcgct caaatgacga gcgtctgatt 1988941 gaattaaagg aaacgtacag cgtgcgtcca tgcagagata aaaatgagtt tttcactcac 1989001 accgatatca ttatcctcgc tttcaaaccg aaagacgcgg cggaaagcat cgacagcatc 1989061 cggccgtata tcaaggacca gcttgtcatt tcagtacttg caggccttac catcgaaacc 1989121 attcagcatt attttggcag aaagctcgcg gtcattcgcg tcatgcctaa tacatcagcg 1989181 gcaatcagaa aatcagcaac cggattttcc gtaagcacgg aagcaagcaa gaatgatatt 1989241 attgccgcaa aagctctatt ggaaacaatc ggtgatgcaa cactggttga ggagcggcat 1989301 cttgacgctg tcactgcaat cgcaggcagc ggcccggcct atgtgtatcg ttatattgag 1989361 gcgatggaaa aagcagcaca aaaagtagga ttagataaag aaacggcaaa agcactcatt 1989421 ttgcagacaa tggcaggggc aacagatatg ctcctccaaa gcggcaaaca gccggaaaag 1989481 ctgcgtaaag aaatcaccag tcctgggggc actacagagg caggtcttcg cgctttacag 1989541 gactcccgct ttgaagaagc aattattcac tgtattgaag aaacagctaa acggagcgca 1989601 gaaatcaaag aacagtttgc cggtgccgcc ttagagagac attcttagat gtaaggacaa 1989661 aaacagaagg cacagtgcct tctgtttttt atttttcccg cagcagctgg ccggcagatt 1989721 ctgattgctt taatagcgcg gagatcgtaa atgaaagcaa atcgggaagc acttcaaagg 1989781 aataaggcat atacaatctt tccgtccatt tatgcgggtc tttaccagcc ggaccgacat 1989841 ttaaaactgg gacatataaa gcctgatttt taccgcttgg caatgaatac cctctgttaa 1989901 agagcggcat attgcttgtg tatgcatcaa cctcctgttt ttccagctga agataactca 1989961 agtccgaaag tccggggaag tactgaacct cccgtaatgc aatgccgtat cgctcagccg 1990021 cataatgctt tatctgatct gctgtatttc tgatcaattg atcatccttt gaagaaacag 1990081 ctggataaag cggcggacta taaaacagaa cgatgagcgg cgcatcctcc ttacaaagcg 1990141 aagcaagctc agaaacaatt ttcgtcgaaa aatccctgtc tccaagctcc cccctgttag 1990201 caaaggcata atttagagcc cgctctgttt ccgagatccc cgcacgcttt tttgcacgcg 1990261 agaccagctc atcaaatgtc aaaacagtga cgtcccgctc aatcggctga aatggctcaa 1990321 attgttgaaa atcctgtgtt ttcttccgaa cgttcgacat gatttcctcc gccgcctgtt 1990381 ctgctgtttt aagcagcatc tgatgcagct cactagctga gcgtttcatt gacagcacat 1990441 taaataatgt gacggctgta tgcggtgtct ggactgaata tgcctctttc aagtcctttt 1990501 gcattaagtt taccggcggc ggagtgacct cgccatcaac cttttcgcaa taatcagcat 1990561 tcagttcaag caaacggtta atctcagata ccattaaatt tgcgtttaga cctgaaaacg 1990621 gctctccaac atgtgtctca atccccttgc agaaaaaacc cgcaagcacc ttgccaatgc 1990681 ttcctgtata aaaatattgc tgctgatcgc cgggaaattt ttcaaacatc ggttcggcat 1990741 tcaggcaagc ggttaatgtg atatcatgct ttttctccat ctccttcaat gcaggaaccg 1990801 cttcaatcat gcctcttgaa ttcacttcct cgtccggaac cgttatcaac agcagattgc 1990861 cctcaaaatg cccgttcatt gccctctcca gcatcgacag ttgaatacaa agccccgctt 1990921 tcatatccat cgtccctctt ccgaacagcc agtctccgct ttcggcatct cttctcacac 1990981 gttccgggag cagctctttt ttctctaaaa aggagctcaa aagctcagca ggcttgcaag 1991041 ccatatgttt aaattcgccg taatcttcta tgtcaacgac atcaaaatga ctcagcagaa 1991101 gcactgtctt tttgacattc ttctttttga ctagagccgt aagaaaagat ctgccatcgt 1991161 ccatcggatg aagtgttaca tcatcagggt gcttttgaaa atagggcttg tccttcaaaa 1991221 taaaataaag atactctgca agcgctacct cgccctttga accggtgatg ctttcgtatt 1991281 gcacaagaga agttaaaagt gccagcaatt cgtccttcgt ctgccaattc attgattccg 1991341 cccctcctat gaataaaaat gcttctatac tgaaaaataa actgatttct cgtctattat 1991401 acagaaatgt ttgacaaaag cggttcattt gagcagttta tatgacggga aagaaatgac 1991461 ttgatataat caatctctaa aaaccttacg ggaggcgaaa gaaatggcca gaaaattatt 1991521 tacacctatt acaattaaag atatgacgtt aaaaaaccgc attgtcatgt cgccaatgtg 1991581 catgtattct tctcatgaaa aggacggaaa attaacaccg ttccacatgg cacattacat 1991641 atcgcgcgca atcggccagg tcggactgat tattgtagag gcgtcagcgg ttaaccctca 1991701 aggacgaatc actgaccaag acttaggcat ttggagcgac gagcatattg aaggctttgc 1991761 aaaactgact gagcaggtca aagaacaagg ttcaaaaatc ggcattcagc ttgcccatgc 1991821 cggacgtaaa gctgagcttg aaggagatat cttcgctcca tcggcgattg cgtttgacga 1991881 acaatcagca acacctgtag aaatgtcagc agaaaaagta aaagaaacgg tccaggagtt 1991941 caagcaagcg gctgcccgcg caaaagaagc cggctttgat gtgattgaaa ttcatgcggc 1992001 gcacggatat ttaattcatg aatttttgtc tccgctttcc aaccatcgaa cagatgaata 1992061 tggcggctca cctgaaaacc gctatcgttt cttgagagag atcattgatg aagtcaaaca 1992121 agtatgggac ggtcctttat ttgtccgtgt atctgcttct gactacactg ataaaggctt 1992181 agacattgcc gatcacatcg gttttgcaaa atggatgaag gagcagggtg ttgacttaat 1992241 tgactgcagc tcaggcgccc ttgttcacgc agacattaac gtattccctg gctatcaggt 1992301 cagcttcgct gagaaaatcc gtgaacaggc ggacatggct actggtgccg tcggcatgat 1992361 tacagacggt tcaatggctg aagaaattct gcaaaacgga cgtgccgacc tcatctttat 1992421 cggcagagag cttttgcggg atccattttt tgcaagaact gctgcgaaac agctcaatac 1992481 agagattccg gcccctgttc aatacgaaag aggctggtaa tgcccataag agatatcctg 1992541 tagaggatat ctcttttttt atttttagag aaacgatcgg ctaaggttct ccgtctccct 1992601 agtagaacca attagaggag atgactccaa tgaaatcagc ttggatggaa aagacatata 1992661 caattgacgg atgtgcgttt catacacagc accggaaagg atcaagcggt gtaacgattg 1992721 tctttgaggc cggctatggt acttcttctg agacgtggaa accattaatg gcggacattg 1992781 atgatgaatt tggcattttc acatatgatc gggcaggcat aggaaaaagc gggcaaagca 1992841 gagctaaacg aacagctgat caacaagtga aagaattgga gagtttgctt aaagcagctg 1992901 atgtaaaacc tccttatttg gctgtttcac actcatacgg agctgtcatc accggtttat 1992961 gggcctgcaa aaacaagcat gatattatcg gcatggtcct tcttgaccca gctttaggcg 1993021 attgcgccag ctttaccttt atacccgaag aaatgcacaa atcacatacg agaaagatga 1993081 tgcttgaggg cacacatgca gagttttcaa aaagtctgca ggagctcaaa aagcggcaag 1993141 tccacttagg aaacatgcct cttcttgtgt tgtcatcagg agaacggact gagaaattcg 1993201 ctgctgaaca ggagtggcaa aacttgcaca gcagcatatt gtctctatct aaccaaagcg 1993261 gctggattca agctaaaaac agctcccaca acatccatca tgatgaacct catatcgttc 1993321 acttggctat ttatgacgta tggtgcgcag cgtgccagca ggccgctcct ctttaccagg 1993381 cagtcaatta acgtaaaaaa agaccgggcc gtaagggatt cccggtcttt tatattattt 1993441 tgtttcacgg tgaagggtat atttctttaa acgcggtgaa tattttttca gctccaaacg 1993501 gtctggattg gtgcgtttat tttttgttgt gatgtaattt cggtctcccg tttcagtgca 1993561 aagctaaagt aacatttact ctcataatta acatctcctt ataaaacgta atgattacgt 1993621 tttattatac aacgtcatca caaattgtca aataagagct ccgccttcag cctcgcggga 1993681 cgtttacctc taagaaatca tatgccgcca cgctattggg gaaaacgtca accgcttctt 1993741 tttgaagctc caaagaagca tctccctgat atcttgcgct gatatgggtt aaaatgagct 1993801 gcttcgctct tgcttctttc gctgttacag ccgcttgttc cgttgtactg tgataataat 1993861 cataagcaag tttacggtct tccttagcaa aggttgcttc atgaacaagc acatcacaat 1993921 ccctcgcaag ctcttttagt ttgtcactta ctctcgtatc accggagaac acaacagatc 1993981 ttcccttttt aggaggctcc agaaaatcat tcccattgat gattcgtccg tcttcaagcg 1994041 ttaccgtttc gccttttttg attttctgat atacaggtcc gggcgggatg ttcatttctt 1994101 ttaatacgtc agccttcaag gaacccggta cgtctttttc ctgcacacgg tacccgaagg 1994161 cttccactcc atgaataaca gataccgctg tgacaataaa ctgatcgtcc tcaaacacga 1994221 ttccttcttc aatttcctgg atcgcaagcg gatatgtcaa atgggttttc gtgacggcaa 1994281 ggcttgtttc aataaacgcc ttgatccctt taggtccgta cactgtcagc tcgtcctctc 1994341 cgccttgaaa ggaacggctc cccagaagcc ccggaagtcc gtatacatga tcgccgtgca 1994401 tgtgtgtaat aaagattttc tctattttac gaggtttaat cgttgtatgt aaaatttgat 1994461 gctgtgtggc ttccccgcag tcaaaaagcc ataccgaacg cctttcttca agcaatttta 1994521 atgccaccga cgttacattt ctcgccttgg cggggatgcc ggctcccgtc cctaaaaaaa 1994581 gtaattccac gtttccttcc tcctactaga accagatacc tacaagaata caggatcaag 1994641 cggaaaatgt gaatcttgcc tctgaaaaga acaatccttt cgtgctagaa acattttttc 1994701 agcattctgc ttaaaaaagg gcttaaatgt ttgctttcgt tgaattttag atttaaaatg 1994761 aaggaaatat acggggtgta ctaaaataaa gcttcgaata aagtgaggta cttttagtga 1994821 aaacaaacca acaaccaaaa gcagtaattg tcatattcgg tgcaactgga gatttagcaa 1994881 aacgaaaatt gtatccgtct attcaccgtt tatatcaaaa cggacaaatc ggagaagagt 1994941 ttgcagtggt aggagttgga agaagacctt ggtctaatga ggatcttcgc caaactgtta 1995001 aaacatccat ttcctcatct gcagataagc atatagatga tttcacgtct catttttact 1995061 atcacccgtt tgacgtgaca aaccctggtt cttatcaaga gctaaacgta ttgcttaacc 1995121 agctggaaga tacatatcaa attcctaaca acagaatgtt ctacttggca atggctcctg 1995181 aattcttcgg aacgattgca aaaacattaa aatcagaggg tgtaacagct acaaccggct 1995241 ggtcccgcct tgtcatcgaa aaaccgttcg gccatgatct gccaagcgca caggcattga 1995301 ataaagaaat ccgcgaagca tttacggaag atcaaattta cagaatcgac cattatctag 1995361 gcaaacaaat ggttcagaac attgaagtga ttcgatttgc caatgcgatt ttcgaaccgc 1995421 tttggacaaa ccgctacatt tcaaacattc aaatcacatc tagcgaatca ctaggcgttg 1995481 aagaccgcgc aagatattac gaaaaatcag gcgcccttcg cgacatggtg caaaaccata 1995541 ttatgcagat ggttgccctt cttgcaatgg agccgcctat caaattgaac acagaagaaa 1995601 tccgcagcga gaaagtgaag gtgctgagag cactgcgtcc tattgcaaaa gacgaagtgg 1995661 atgaatactt tgtgcgcgga caatatcatg ctggtgaaat tgacggtgta ccggttcctg 1995721 cttatacaga tgaagataat gtcgctcctg actccaatac agaaaccttt gttgccggca 1995781 agctcttgat cgacaacttc agatgggctg gtgttccatt ctacatcaga accggaaaac 1995841 gaatgaaaga aaagtccaca aaaattgtcg ttcaatttaa ggacattccg atgaacctgt 1995901 actacggtaa tgaaaacaac atgaatccga acttgcttgt cattcatatt cagcctgacg 1995961 aaggcattac gctttactta aatgctaaaa agcttggcgg agcagcacac gcacagccaa 1996021 tcaaactcga ttattgcagc aattgcaatg acgagttgaa cacccctgaa gcatatgaaa 1996081 aactaattca cgactgtctt cttggcgatg caacaaactt tgcacactgg gatgaagttg 1996141 ccctttcttg gagctttgtc gactctattt ctgaaacatg ggcagcaaac aaaaccttat 1996201 ctcctaacta cgaatcaggc tcaatgggac cgaaagaatc tgatgatctt ttggtgaaag 1996261 acggcttaca ctggtggaac atataataag aagaaaaaag ccgaaaatgt ttacaagcat 1996321 tttcggcttt tttacgctga acaaaggtat aacaatctcc ttaataacaa aacccccaaa 1996381 gcttaagagc ttcgggggtt tctattgatt acttcatcca ttcagtatgg aagatgcctt 1996441 ctttgtcagt acgctcataa gtatgagcgc caaagtagtc gcgctgtgct tggattaagt 1996501 ttgcaggcag tacggctgtg cggtagctgt catagtaggc taatgcgctt gagaatgatg 1996561 gcaccggcac accttgggca actgcaagtg aaatcacttg gcgaagcgct ccttgatagc 1996621 tttctacaat attcttgaaa tagctgtcaa gaagcaggtt gtcaagctca ggctcgcgat 1996681 cgtaagcttc tttgatcttc tgaaggaatg ccgcgcgaat gatgcaacca ccgcggaaga 1996741 tcatagcgat ttcaccatat ttcagatccc agttgtattc ttcagaagca gctttcattt 1996801 gggcaaatcc ttgcgcgtat gaacagattt tactcatgaa caacgctttt ctgaccgctt 1996861 caatcagctc ttctttattt tctgtaacag gcttcacttc tggtcctgaa agaagtccgc 1996921 tcgcttttac acgctcttcc ttcatagctg agataaagcg tgcgaataca gattcagtaa 1996981 taatcggaag cggaacgcct aagtcaagtg cgctttggct tgtccatttt cctgttcctt 1997041 tttggcctgc tttatcaaga atcacatcaa caagcggttt gcctgtttct tcgtcttttt 1997101 ttgtgaagat gtcagccgta atctcaatca ggtagctatc aagctcacct ttattccatt 1997161 cagcgaaaac ttcatgaagc tcatcagcag aaaggcccag cacctgtttc agaatgaaat 1997221 atgattcaga gatcagctgc atatctccgt attcaattcc gttgtgcacc atttttacgt 1997281 aatggccggc gccgtccgga ccgatatatg tcgtacaagg ttctccgtca acttttgcag 1997341 aaatggcttc aagaatcggt tttacaagct catgtgcttc tttttgtccg ccaggcatga 1997401 tagaaggtcc tttaagcgct ccttcttctc cgccggaaac gcctgttccg ataaaatgaa 1997461 tgccgctttc agcgagttct ttgttacggc gctgtgtatc tttatagtat gtattaccgc 1997521 cgtcaattaa aatatcatcc ttctctagat gaggaagaag agattgaatt gtcgcatctg 1997581 ttgcagttcc cgctttaacc attaataaga ttttgcgcgg tgtttccaag gattggacaa 1997641 attcttcaat gctgtaagtg ccaacaacat tttttccttt tgcctcctgt aaaaactcct 1997701 cagttttact gcttgatctg ttgtaaacag aaacagaaaa tccccggctt tcgatattta 1997761 aagccagatt tttacccatg accgcaagtc cgataacgcc gatttgttgt tttgacatat 1997821 tctaacgtcc cttctgcaaa cgtttaatca ttttaaaatt taaattaaaa taaaatgata 1997881 tttataataa agaaattacc atacattcac cctttttttc aagcgattca gcttttcttt 1997941 tcatcttgaa aaaaatcttt attaaagctt gttccctttg ttttgctctc ctcttttttt 1998001 aacgttgccc cttttctgat cagtttggta ccgtactttt tattcagctt ttccatcatc 1998061 tgctgaatgg gctcatcctt cgcatcttca ttaaagctga acaaatcgag ctgtttatag 1998121 gcctgctctt tttctactaa atccgttccg gtaatgccaa gcagcctgac aggattttta 1998181 ttccaatgtt taaaaaagag gtgctccgct tctttcaaaa tgtcattttt ttgatcaatc 1998241 gggtttctca gcgtagtgct tcttgtgatg gttctccaat ccgcatatct aatcataata 1998301 aaaagcttcg aagccatgac ttccttgcgc tgtaaacggt cactcacaga agcggcaagc 1998361 tttctaaaaa cgcctaacag ctcttcttca tcactggaat catgggaaag tgtcgatgag 1998421 ttgccgacgc ttttaaattc gtaaatgcgc tccgggtcaa ccggcgcatg gtgaatgcca 1998481 tttgctttat ttttaaggcg cggaccgttg atgccaagca ggcgcttcag cgagtgttca 1998541 tcagctgcag ctagctctcc gattgtatgg atgccgagtc ccttcagttt ttccgctgtc 1998601 tttttgccga ctccgtgcat ctctccaaca ggaagcggcc acaggatatc gggcacttgc 1998661 ctctttctta agatcgtaat tccaagcggt tttttcatat cagacgccat cttagcgaga 1998721 aatttattcg gtgcaatccc tatgcttgac gggagcagca gctctttttg cagcctgctt 1998781 tggatttctt ttgccgtctc tagagcgcgg ctgctgtatg gtgtatcggt catgtccata 1998841 tagccttcgt cgatggagac aggctccact aggtcagtat attcacgaag aatggtaaac 1998901 atcgctcgtg aagagtttct atagcggtca aagttcggcg gaagaacgat gagctcagga 1998961 caatggcgct tcgcttgcca aaccggcatc gttgttttga cgccgcgcgc tcttgcttcg 1999021 tagctgcatg ttaccacaat gccctttcgc tcctttacgt ttccggcaac tgcgaccggc 1999081 tttccccgga gagccggatc atatgccatt tcaaccgacg cataaaagct attcatatca 1999141 atatggaaaa taattcggct ctttcccggc ataaacaaat ctccttttcg gtcattagac 1999201 aacagcttgt acatatagta aaatgaagct attgaatgga tgtgatgaca atgtttgtgg 1999261 aatcgataaa tgacgtttta ttcttagtcg attttttcac aattattctt cctgctctaa 1999321 cggcaatcgg gattgcattc ctcttacggg agtgccgtgc gggcgagcaa tggaaatcaa 1999381 aacgaacaga tgaacatcag acggtctttc acattaaccg aacagacttt cttattatta 1999441 tatatcatcg cattacaact tggatacgta aagtcttccg catgaattcg cctgtgaacg 1999501 atgaggaaga cgccggttct cttcttttat aaaccgcatt tataaaaagg aggagaacaa 1999561 aattgttaaa aacatatcaa aaacttttgg ctatgggtat ctttttgatc gtattatgct 1999621 cgggcaatgc tgcatttgca gcgactaatc aggtgggagg cctcagcaac gtaggttttt 1999681 tccacgatta tttaatcgaa ccgttttccg ctctgcttaa gggtgttgcc gggctgtttc 1999741 acggagaata cggactctct attatcctcg taaccattat tgtgcgtata gttgtattgc 1999801 ctttgtttgt caatcagttc aaaaaacagc gcatcttcca agagaaaatg gccgttatta 1999861 aacctcaggt tgacagtatc caggttaagt tgaaaaagac gaaggacccg gaaaagcaaa 1999921 aagagctgca aatggaaatg atgaagctgt atcaggagca taatatcaac ccgcttgcga 1999981 tgggctgtct tccaatgctg attcagtctc cgattatgat tgggctttat tacgcgattc 2000041 gctcaacacc tgaaattgcg tcacactcgt ttctatggtt cagtttaggg caatctgata 2000101 ttctcatgtc ccttagtgca gggattatgt attttgtcca agcctatatc gctcaaaaac 2000161 tgagcgcgaa atattccgct gtcccgcaaa accctgcagc gcagcaatcc gcaaaattga 2000221 tggtgttcat cttccctgtg atgatgacga ttttctcgct taatgtgccg gcagcccttc 2000281 cgctgtactg gtttacaagc ggactgtttt tgacagtgca aaacatcgtc cttcagatga 2000341 cgcatcataa aagtaaaaaa acagccgctc ttactgagtc ggtgaaataa aaaagcaacc 2000401 ccgtgcaaaa agccggggtt gttttttgtt acttgcaaag taccgcgcca aacagtcttg 2000461 tttatcatgg ctgaagcaga aatggccatc ctaaaaaata gccgtatcgt ttaaaaagaa 2000521 ggaaatcggg aataccttta ctcacctcca accgaaagga gcctatacgt tgacggaacg 2000581 ctttcagcaa aaaaatattt ctgtacctga tggaatctgg atcatgagac aaacctggaa 2000641 tgatgtctta tttgctcact ggcctgttga tgtttctatc cttcgcgctt tggtaccgtc 2000701 cgttttagaa ttagatacat ataacgggca agcttggatc agcatgcttc cctttatgct 2000761 cacgaacctg agggcgcgtt atctccctgt cattcccggt gcgcgtgcat ttcctgagct 2000821 taacctccgc acctatgtca cgtataaagg caagcccggc atttattttt ttagcttaga 2000881 tgccgatcat cgtctggcgg tccttggcgc tcgcacattc tttcatctgc cttattttta 2000941 cgcggatatg aagtccgaaa aaaacggtga tgccattgac tatgtcagca agcggaaaaa 2001001 tgacaaagaa gcagcattcc acgccgcata ccggccaatt tcagcgcctt ttacagcaga 2001061 aaaggattcg ctcgattact ggctgacaga acgatacagg ctctacacca cttatcgcaa 2001121 taagctctat tacgaagaca tccatcatca tccgtggctg ctgcaaaacg ccgaagcaga 2001181 aatttcagtc aatacggtga ctgatgctca cggtattaca ttgccggagt cagacccctt 2001241 gcttcattat gctaaaaaac aggatgtgtt attttggccg cttaggaaat ggagctaaaa 2001301 aaacccgatg cgggaaatcg cactcgggtt ttcttttttt attttgccgc ctcttcaata 2001361 atggcaacaa ccatttctgc cgttttaacg agctcttcga tcggcatttt ttcatttttt 2001421 gtatggattt gctcataacc gacagcaaga ttgaccgtcg ggatgccatg accagcgatt 2001481 acgttcgcgt cgcttccgcc gccgctcgtt tgcagctcgc ttggacgtcc gattttagca 2001541 gccgcttttt tcgcgatttc aacaacttgg tcgccgtctt gatatttaaa gcccggatac 2001601 ataacctcaa tttcgacttc tgcgcgtccg cccatatcag cagctgcctc ttcaaaagca 2001661 gctttcattt tttgaacctg agcttccatt ttctcaggaa ctaaagagcg cgcttcagca 2001721 agaatatgaa cttcgtcgca cacaatgttt gtttgtgtgc cgccttcaaa ccggccgata 2001781 ttagctgttg tttcttcatc gatacggccc aatggcattt ttgagatggc tttgctagcg 2001841 attgtaatcg ctgaaatgcc tttttcaggt tcaaccccgg cgtgagcggt tttcccgaaa 2001901 attgccgctc ttaccttcgc ctgtgtcggc gcggccacaa tgatatttcc gacttttccg 2001961 tctgaatcaa gagcatagcc gtaggatgca gtgatcatag aacggtcaag cgccttcgct 2002021 ccgatcagac ccgattcttc ccctactgtg atgatgaatt caatcgtgcc gtgttcaata 2002081 ttttcttctt tcagcacctt aatcgcctca aacattgcag ccaatcccgc tttatcatca 2002141 gcacctaaaa tcgtcgtgcc gtcagttttg acgtaaccgt tctctacaac tggttttacg 2002201 ccgtttccgg gtacaactgt gtccatatga gatgtaaaat agatcgtatc tgtttgtttt 2002261 gtccctttta gcgtgcaaat caggttaccg gctccgtggc ccgtgatatc cattgtatcg 2002321 tcttctttaa cgtccacacc taaatcagaa aattttcgtt tcagcacttt gcagatttca 2002381 gcttcgtgct ttgtttctga gtcaatttgg acaagctcta aaaattcttc cagcaggcgt 2002441 ttttcattca ccatttgtaa gtccctccat attaaagcgg tatgttaccg tgcttttttt 2002501 tcggtctctc ttctgtctta tgtgtaagca tatgaaaagc ttgaatcagt cttccccttg 2002561 attcttccgg caaaatgatg tcatcgacca ttccacaagc ggccgctttg tatgggccgg 2002621 cgttttgctt tttgtattca gcagtttttt cgcgtttcgt cttttgcggg tcagctgaag 2002681 ctttgatttc cttttcatac aaaatcgatg ccgcaccttc tggacccatc actgcgattt 2002741 cagcattcgg ccatgcaaac acaaggtccg ctccgatcgc tttgctgttc atggccacat 2002801 aggcgccgcc gtacgctttt ctaatgatga gtgtgacttt tgggacagtc gcttcagcat 2002861 aagcaaacaa taattttgct ccatgcctga tgattccgtt gtgctcttgc tgaatacccg 2002921 gcagaaaccc cgggacatct tcgacagtca acagcgggat atcaaatgcg tcacaaaaac 2002981 ggatgaacct tgctgcttta tcagcagcgt caatcgtcag gcttcccgcc agatgcttcg 2003041 gctggctcgc cacgatgccg attgcttttt cacccagcct tgcaaaccca atgacaatgt 2003101 tcttcgcaaa aaatggctga atctcaaaaa aagactgcgg gtcagccagc tccctaatca 2003161 ccttccgaac atcataaggc tttgtcgtat cagcagggac aagacggttt aataacggtc 2003221 tggacgcctc tttctctggc ttcggctctg ttgtccggcc attcagcggc aaataagaca 2003281 gtagttttct cacccctgtc agaacctcct tctccgtatg cccggaaaag tgggcgtttc 2003341 cgctgacggc attatgtatc cccgctccgc ctaagctctc cgcatcaacc tgttcccctg 2003401 tcactttttc aatcaccttc gggccggtaa taaacatccg gccagtctgt tcagccataa 2003461 atataaaatc tgtgagtgcc ggagaatata cagcgcctcc agcgcacggc cctaaaataa 2003521 ccgatatttg cggaatgact ccggaatata agacgtttcg gtaaaatatg tgaccgtatc 2003581 catctaatga taacacaccc tcttgaattc tcgcaccacc tgagtcattc agcccgataa 2003641 tcggcgcctt attttttgct gccagatcca tcaaagcgca gattttcctg gcatgggttt 2003701 cgccaagcgc ccctccgtac actgtgaagt cttgcgcaaa tacataaact gagcgaccgt 2003761 caattgtgcc gtaccctgtc acgaccccat cccctaacat gcgctgttct cttgttaaca 2003821 cttgactttc catgaagggg tgtaattcga taaagctgtc ctgatctaga agaaatatga 2003881 tcctttcccg agcagtgagc ttgccctttt gccgctgctg agccagcttt tcccgtcctc 2003941 cgccttcttc tgcctgcttg cgtttcgtgt aaaaatgatc catgtgctca ttcatgctca 2004001 ttgtgttggt ctcctttcgg ttcacaaagc tctacaagaa caccgtttgt ttcccgaggg 2004061 gaaataaacg cgatcttttt cccgttcgct ccctgtcttg gaaacctgtc aatcaattga 2004121 acatgctgat cagacaatgc ttgaagctgt tcagataggc agttgcacaa aaacgcaata 2004181 tgatgcagtc cctgcccttt cttctccaaa aataaatgga cggggctgtc agctgtcaac 2004241 ggctctatca gctcaagttt gacgctacca gcttgaaaaa aagcaacatt caccttttgc 2004301 tcttcaaccg tttcttgatg aagaaatgca agccccaata cattttcata aaagcttctt 2004361 gcatctttta tcgaaaaaac ggctatcccg atatggtcaa gcctgttcat tttcatccct 2004421 gctttcgcta atagatatcg cttgtccgcc cattcaaaac acgctaaaat atagacagat 2004481 tgtttaagga gtgaaaatca tgtctcaaaa actgatgaaa agcgttttga tcgtgatttt 2004541 gggagttttt attctttcaa ctgtactctc aggaatcgtc atgtttctat aacgataaaa 2004601 aagcaggcgc cttattcaat gggaatatcc tgctttttta tcagagcttt atgctcgatg 2004661 gcaatctcct caaaagagcg gttgtcgtcc gtgatcagca ctctcgttcc tactggtatc 2004721 gtttgaaaca aatgaacaac ctcatcgtta tgcatacgta tacagccgtt agacacaaat 2004781 tttcctactg attcctctcg gtttgtccca tgaattccat aaatccgccc gtccgttcct 2004841 ttcgcgtcaa atccgatcca tcttgcccca agcgggttat caggagatcc cccttcaata 2004901 tttttctttc tgtagtaagg attttccgct tttaccgtta ccgaaaactc tccttcaggc 2004961 gtcaaatcat ctgtttttcc agtcgccaca ctatacacgc cttctacttt gttgtcgagg 2005021 ataacagcaa gttcatttgt tcgcttgttg acaataacat acggatcacc cggcagcgga 2005081 ttttcgccga gcggccaaat cggtgaaatc atcatgaaaa tcgaacataa gaaaaaacgc 2005141 ataagctcct cctttttcat taggttgacc aatgaaggaa gagctcatgc gaatcatccg 2005201 agtgattttt gcgcttttat tcctttaaaa taacttttaa tcactaaata ttgttccatt 2005261 tcgccgagaa gatggaagag agcggccctc gcttcaaatt cctctctagt cgcaggaagc 2005321 ggcatctcct caaattcttt tctcatgtca gcaagtcttt tcagaaattt gtatgctgta 2005381 ttcccagggt gtatcgcctc ccgcaaatca tgaataaatt cagcgatcat ttttccctga 2005441 tctaccgtga tggagatcga tgtcacttta gggagaaggc gttcgataat ttcaaattgc 2005501 ttttctctca ttttaaaata atgataatgc agattttcat aacgcaaaat gtggttttgc 2005561 acatctcgat atgccaggtt tttagcctcc gtaatgagct ggtgcgtttc cggaatttct 2005621 tttcctgacc aatcttgctc accagttaac aaataccgtt cgatttctgc aaaaatgaca 2005681 gcaaagttat cctctatctt tttgcggtag gcaatcagtt tccggtcaag actaggcata 2005741 tacaagttca tcaatagagc gacgccgatg ccaaccgtaa tcagctgaac ttcattccag 2005801 atgaaagtag gcgtaatgcc gccggacatg tataaatgaa ggataataac agaactggtg 2005861 acgataccct cgttaatttt taacagaacc gttatcggaa tgaatatcaa aagaagcgct 2005921 ccgatcacaa acgggtggta gccaataagc tcgaaaaaga gataagaaaa agcaattgcc 2005981 agacagcatg ccgaaaagcg ggcccatgag gcctgaagcg accgtttttg tgtgatttgt 2006041 atgcacaaaa tggtgatgat tcctgctgat gcgaagtttt gcaaatgcaa taactggctt 2006101 atataaatag ccaaagctgt tccaagcgcg gtctttattg tgcggtaacc aattttaaac 2006161 atgtcggact ccatttctat ttgtttcttc aataaaaaag aagaggcggc cagccttctt 2006221 cttttttata ttctataata ttttctctaa aaagtcctgc gctcttttgg attttggcga 2006281 cataaaaaat tccttcggat tgccgtcttc gacaatcatt ccttggtcca taaacagcac 2006341 acggtctgcc acttcttttg cgaagcccat ttcatgtgtg acaatcacca tggtcatgcc 2006401 ggtttcgacc agctctttca tcacctgtag cacttctttg accatctctg gatcaagggc 2006461 ggaggtcggc tcgtcaaaca gcatgatgtc cggattcatc gcaagagccc tggcaatcgc 2006521 gacacgctgt ttttgtccgc cagacaaacg gtttggatag tcatttcgct tttcaaacaa 2006581 accgactttg cggagcaggt cctcagcttt ctcctgtgca gcctgttttg attctttttt 2006641 tacattgaca ggcgcgtaca tgatgttttc gagaaccgtt ttgtgcggaa agagatgaaa 2006701 atgctgaaaa accatcccga tgttttcccg gacctttaat gtgttggttt tcggcttcgt 2006761 aatctctgtg tcttttattg taatggttcc gccgttaggc ttttccaaca ggtttaaaca 2006821 gcgtaagaac gttgatttgc ctgagcctga aggaccgatc acggcaacaa cctcaccctc 2006881 agcgattgtt gttgaaatgt tttttaatac ttcgtgtttc ccaaatgatt ttgacagctt 2006941 ttcaacctta atcattggat ttcagcttcc tttctacagc cttgccgata aacgttaaaa 2007001 tcaggacaag cacataataa atcaatcccg cgataatgag cggctcaagg taattgtaag 2007061 tggcggcgcc agcttgatat gcgcgtctca tgacatcacc aagcccgatg acggtgacga 2007121 tcgccgattc ttttgttaac gtaattaatt cattcacaat tgcaggtgat atatttttga 2007181 aggcctgcgg cagcagcaga tccttcatca tttttccata cgggacaccg agtgcaacag 2007241 cagcttcttt ttgcccttta tcaatggcat tgattccggc tctgataatt tccgatacat 2007301 aagcggcgga attcaaagac aatgcgacaa ccgcagccca aaactggtca atttgaaatc 2007361 cgagcagctg aggaaggcca aaatagacaa tcataagctg cagcactaaa ggcgtgcctc 2007421 ggaacactga tgtataaaaa tcagcgatcc agataaacgg gcggaatgtg ctgatcttgc 2007481 ataagcttag cacaataccg agtataagtc cgataatagc agatacaaca acaattttta 2007541 atgtaattgc caagccttct aatataaaag gaatttgggg gatcgttgct gaaaaatcca 2007601 aattcatagc ctttgtctcc ttttcttaca ggaaaaaagt ttcctattca ataaaaaggc 2007661 tcaacgaaaa agttgagccg ctttttttta cttctcgcca gtgaaccatt ttttcttcaa 2007721 tttctcaagc tctccgttat cttccatttc cttgagcgct ttattgaatt tgtctgtcag 2007781 ttcactgtcc tttctgaaag caattgctga accggcttct tccgctttcg catcaggaat 2007841 cacaaagcct tgcaggtcat catttgattt gaaataccct tctgcaacaa tgtcttcaat 2007901 aatcgcggca tcgaagcggt cagatttgat ttcctgcacc aaatcagaaa ttctgttgcg 2007961 gtcttctgtt ttaaaaccat attccggaga aagctctttc cccttctctt cctgaataga 2008021 gccaagctga acgccaactg tttttccttt caggtctttc aaagattgaa tgccgctgtc 2008081 ttttttgctg acaatcatat ggttcgctgt gtaatacaca tcggaaaaat caacttgttt 2008141 tttacgctca ggcgttggtg tcattcctga cagaacgaga tccacctgtt ttgatttaag 2008201 cgctgtaatt aagctgttga agtccatatc ctgcacttca atttcatagc ctgccttctt 2008261 tgccagagct tttgccagct ctacatcaaa gccgacaata ttatctcctt ctttatattc 2008321 aaacggtttg taatccgccg aagtacccat aattaatttt ttctttccgc tttctgaacc 2008381 tgaattgctt gagccgcacg cagttaatgc aaaggtgatg caagcagcca caagtaataa 2008441 gagccatttt ttcatgatcc atttcccccg tattcattac ttttggtgta tttgaatatt 2008501 tattcgttaa tttgtatttt aaacagtttc tcatttttat gcaatactat ttttaaaaat 2008561 tatctttagg cttatctttc cagtgatctc ttctgatatt actagataaa aattaaatcg 2008621 ctgtacaatc cgattgaata atcccttaat atttattcat atatccttgg aaatttatgc 2008681 acaaaaaaac ccgggctgct ttgagcatcc gggttgttcg tcttatactt cttcacaata 2008741 ttcttcaaag gcttcctgca gctttgccac tacagccatc ggctcatggc cttcaatttc 2008801 atgacgctct accattttca tgatctttcc gtctttcaaa atcgcaaagg acggagaaga 2008861 tggtggataa ccttcaaaat agtcacgcgc acgcgctgtc gcttctttat cctgtccggc 2008921 aaaaacggtg acgagctgat caggtctttt atcatagtga acggaatggt aggctgccgg 2008981 tcttgcaatt cctccggcgc atccgcaaac agagtttacc atgacgagcg tcgttccttt 2009041 tttcgtaagt gcctcatcca cctcttcggc tgttttaagc tcggtgtatc cggcagctgt 2009101 tatttcttgt ctcgcttggc ggacaatatc attcataaat aaattaaagt ccatgttcaa 2009161 tgaagacctc tcctttttca tcatctgttc ttatgatagc aaggaaacgt ccatatcggc 2009221 aaatgacttt gcttcgccgt gcactttttt tgctcttcgt ttactgctta cagaaaaagg 2009281 ggattatata accagaagta aaataaagga gcagttgtat atgagccacc ggaaagcgtt 2009341 actgattcat aacggaaatg ccggcaacaa aaatatagaa aaagcacttg gtgctgtggt 2009401 gccggtttta tctcaccatt tagatgaggt gattattaaa cagacaaaga aaaaggatga 2009461 tgcgtatcat ttttgccgat ccattgatga ttctgtcgac accgtcttca ttctcggcgg 2009521 cgacggcacg atccatcaat gcataaatgc tatcagcgct ctagaaagaa aacccgctgt 2009581 cggaattttg cccggcggca cgtgcaacga cttttcaaga gtgcttggca tccctcaaaa 2009641 tcttgcaaag gccgcggaag cacttatggc gggaaaaaaa accagcgtag acgtatgtca 2009701 gatgaatgac cgttattttt tgaatttctg ggggatcggc ttaattgcag aaacgtcgaa 2009761 tcaaatcaac gaaacggaaa aagcattatt gggaaaaatc agctatttta caagtgcctt 2009821 gcgaaccgtc tcatctgctg catcgtttcc gatgacatta aaaattgatg gagaagaaat 2009881 taaagaagaa gccgttatgc tgcttgtgat gaatggccaa tacattggaa cgaatcgaat 2009941 tcctctgccc gatgccagta ttgaagacgg cttacttgat gttctcatat gccgcaatac 2010001 caacctcacc gcgctgcggg agctgatgag catggaacaa ggctcaattg atcgttttac 2010061 tggagagttg tcctatgtcc aggcttcccg tatcgagatt gaaacagaca ctgccaaaaa 2010121 ggcggatatg gatggagaag tttatacaca tacacccgca gtcattcagg tcctgccaca 2010181 gcatatcgac atgcttgttc ccgcaaatga ataactgtca taaggcttta gaaagatttt 2010241 gcaaatccgt tgactctccc ctaggaggag gtcttacagt ataagggata cacacttgaa 2010301 aaaggggaag tcatatggag aagaaaaata ttaccttaac tatattatta accaatttat 2010361 ttattgcttt tttggggatc gggcttgtga ttccagtaac gccgaccatt atgaatgaat 2010421 tgcatttatc ggggaccgcg gtcggctata tggttgcctg cttcgctatt acacagctca 2010481 ttgtctcacc aatagccgga cgatgggttg atcgcttcgg gcgcaagatc atgatcgtaa 2010541 tcggcctgtt gttctttagt gtgtcggagt ttttgttcgg cattggaaaa acagttgaga 2010601 tgttatttat ctcccgtatg ctgggcggta tcagcgcagc cttcattatg cccggggtca 2010661 cggcttttat tgcagatatc acgaccatta aaacacggcc aaaagcgctc ggttatatgt 2010721 cagccgctat ttcaacagga tttattatcg gccccggcat cgggggattt ttagcagaag 2010781 tccattcccg gctgcctttt ttctttgcgg cagcttttgc actgttagca gccattttat 2010841 caatcctcac gctgcgcgag ccggaacgaa accctgaaaa tcaggaaata aaaggacaga 2010901 agacaggctt taaacgaatt tttgccccca tgtatttcat agcttttctc attatcttaa 2010961 tttcgtcttt tggtttagca tcatttgaat ctttatttgc attattcgtg gatcataaat 2011021 tcggatttac ggccagcgac attgccatta tgattacagg aggagcgatt gttggcgcca 2011081 ttacgcaagt cgtcttattc gaccgcttca caagatggtt tggcgaaatt catttaattc 2011141 ggtacagctt aattctctcg acgagtctgg tattcttgct gacaacggta cattcatatg 2011201 ttgcgattct gctggtgaca gtcaccgtat ttgtcggatt tgatctcatg cggcctgcgg 2011261 taacgactta cctgtcaaag attgcgggaa atgaacaggg gtttgccggc ggtatgaatt 2011321 caatgtttac aagtatcggc aatgtattcg ggcctattat cggcggaatg ctgttcgata 2011381 tagatgtaaa ctatcctttc tactttgcaa cggtcacctt agccataggg attgcactga 2011441 ccattgcttg gaaagcgcct gcacatctta aagccagcac gtgataagaa gcgcattctt 2011501 tgtgtactgc aaagaatgcg cttcttcttt atactgatga tagaaggagt gatggcatga 2011561 aggaatcgta ttactcaatt ggggaagtat caaaactggc aaacgtgtcg ataaaagcgc 2011621 tccgttatta cgataaaatt gatttattta aaccagccta cgtcgacccg gataccagct 2011681 accgctatta tacagattct cagctcattc atctggattt gatcaaatca ttgaaatata 2011741 tcggcacacc tttagaagag atgaaaaaag cacaggactt agagatggaa gaactgtttg 2011801 ctttttatac agagcaggag aggcaaatca gggagaaatt agacttttta tcagccctgg 2011861 agcaaaccat ttcattggtg aaaaagcgga tgaaacggca gatggaatat cccgcgctcg 2011921 gtgaggtgtt tgttttagat gaagaagaaa tacggatcat tcagacagag gcagaaggaa 2011981 tcgggcctga aaacgtgctc aacgcctcct acagcaaatt aaaaaaattt atcgagtcag 2012041 cagatggatt tacgaacaat agctacggcg ctactttctc ttttcagccc tacaccagca 2012101 ttgatgaaat gacttaccgt catattttca cacctgtatt gacgaataaa cagatttcat 2012161 caattacgcc ggatatggaa atcacaacga tccctaaagg gaggtatgcg tgtatcgcgt 2012221 ataatttttc gcctgaacat tattttctca acttacagaa gcttatcaaa tatatcgcgg 2012281 accgccaatt aacagttgtc agtgatgtat acgagttaat cataccgatt cattactccc 2012341 cgaaaaaaca agaagaatat cgagtcgaaa tgaaaatacg gatcgctgaa taataaagca 2012401 tagaaaaaga gcattttttg aaacaaaact tcaaaaaatg ctctttttgc ttatttagta 2012461 aacagatgtc ttctcgtcaa tcgattctaa aatttgtttc actcgtccga ggaatcgtcc 2012521 gcacacgaga ccgtcaagca ctctgtgatc taatgacagg cacagattaa ccatgtctct 2012581 gacagcaatc atgccattgt ccatgacaac cgggcgtttg acgatggatt ctacttgaag 2012641 aatcgcagcc tgagggtagt tgataatgcc catcgactga acagacccga acgaacctgt 2012701 gttgttgacg gtaaacgtgc ctccctgcat gtcatctgca gtgagttttc cgtctcttac 2012761 ttttttagct aggccggtaa tgtctttcgc aatgccttta attgtttttt catcagcgtt 2012821 tttaatcacc ggaacaaata aagaatcctc tgtggcaact gcaattgaaa tattgatatc 2012881 ctttttctga ataattttgt cccccgccca catgctattc atttgcggga attcttttaa 2012941 cgcctgagcg accgctttta caaaaaaggc gaagaacgtt aaattaaagc cttctgtctt 2013001 cttaaaagaa tcttttatac tgttgcgata tgcaaccata tttgtgacgt cgacttccat 2013061 catcgtccaa gcatgcggaa tttctgtttt gcttcgcttc atattggaag caattgcttt 2013121 tcttacacct gtgacaggga tttctttatc accggctgca gacgcaggat atgacgtctc 2013181 ttcttttggc tcaggttttg atgcagactt cggtgcagga gctgctgttt tcagctcctc 2013241 aggattctgt tcttgcacgc cgcctgtttc aattaagcgc tgaatatctt ttcgtgtgat 2013301 gcgcccgccg gcaccagttc ctgtcacttg atcgaggtca atgccgtgct ctccggccaa 2013361 acggagaaca gctggcgagt agcgcttttt attgggctga tcggctgctc cagcactttt 2013421 tgcaacaggg ttctcagcgg cttctgatgc tgctggctgt tcttgttttt gttcagccgg 2013481 attcgcgcct tctgtttcaa ttttgcaaat catttctccg acttgcaggg tttggccttc 2013541 ttctcccaca agctctgtta tcgtaccagt aaaagaagac ggaacctctg catttacctt 2013601 atctgtcatg acttccgcga tcggatcgta tttgttcact ttatcaccgg gggcgacaag 2013661 ccatttgctg atcgtcccct ctgttacgct ttctccaagc tgcggcatcg tcatttgttc 2013721 aattgccatg attgtatcct cccttacgtc tttaaaactc cgctaattct ctcatcgccg 2013781 cttccacttt atcagggttg accataaagt atttttccat tgtcggcgca taaggcatag 2013841 ccggaatatc aggacctgca agccgtttga tcggcgcgtc taagtcgaac agacaatgct 2013901 cggatataat tgcggctact tcgctcatga tgctgccttc ttttgtatct tctgtgacca 2013961 aaagaacctt tccagttttg gacgcagctt cgatgatggc ttctttatca agcgggtaaa 2014021 ctgttcttaa atccaccaca tgcgctgaaa tgccatcttt ttcgagacgt tctgcagctt 2014081 gtaaggcgaa gtggacacac aggccgtatg tgatcactgt gatgtcgtcg ccttcccttt 2014141 ttacgtccgc cttgccgatt ggcaggacat aatcatcagc cggaacctcg ccctttatca 2014201 gacggtatgc ccgcttgtgc tcaaaaaaca gcacggggtc ttcgtcacga actgcggctt 2014261 ttaagagccc tttcgcgtca tatggtgttg atggcatgac aattttcagt ccgggctggt 2014321 tggcgaaaat tgcttcgact gattgagaat gatacagggc tccgtgcacg cctccgccgt 2014381 atggcgctct gacgacaatc ggacagctcc agtcattgtt gctgcggtag cggattttag 2014441 ccgcttcaga aataatttgg ttgactgccg gcataatgaa atcagcaaac tgcatttcag 2014501 caatcggtct cattccgtac attgccgctc cgataccgac tcctgcgatt gcagattcag 2014561 caagcggcgt atccataacg cgctcttccc caaattgttc atagagtccc gctgtcgctt 2014621 taaacacacc gccttttctt cctacatctt ccccaaggac gaaaacgcga gaatctcgtt 2014681 ccatttcttc tttcatcgcc aaattgattg catcaatata tgacattact gacatttgtt 2014741 cttcctccct acttcgcata aacataatca agcgctgact caggagctgc atatggggcg 2014801 ttctccgctt catccgtcgc ttcatttacg attgccataa tttcatccag catggtttgt 2014861 tctatctcat cggacagcag gcctgtttcc tttaagtaag cttgataagt aagcagggga 2014921 tcactttttt tcgcttcctc tacttcttca cggcctctgt agctgctgtc atcgtcatca 2014981 ctggaatgtg gtgtaaggcg gtaagaaatc gtttcaatta atgtcgggcc ttctcctctg 2015041 cgtgcccttt cgcgtgcttc tttaaccgct tgataaactt ccagcggatc atttccattc 2015101 acagttacgc caggcatccc atagcctatg gcacggtcgg aaatgttctc acatgcgact 2015161 tgcttatcgt aaggcactga gattgcgtat ttgttgtttt cacacatgaa aataaccggc 2015221 agcttatgga cagcggcaaa gtttgcccct tcatggaaat cgccttggtt tgaagaccct 2015281 tccccgaatg taacaaaggc tgcgatatcc tttttctcca tacgtcccgc aagcgcaata 2015341 ccgactgcgt gcggcacttg cgttgtaacc ggagatgatc ccgtcacaat gcggtttttc 2015401 ttttgtccga aatgtcccgg catctggcgg cctcctgagt tcggatctgc tgcttttgca 2015461 aacccggaca tcattaagtc ctttgctgtc atgccaaacg cgagcacgac acccatgtct 2015521 ctgtagtacg gcaatacata atccatttca cggtcaagtg cgaaagccgc tcctacctgt 2015581 gctgcttcct gtccttgaca agagattaca aatggaattt tgccagaacg gtttaacagc 2015641 cacattcttt catcgatttt tcttgctaac agcatggttc tatacatatc aacggcttcc 2015701 tgatcagtca gccctagtgc ttgatgtcgg tttgtactca ttcaagcccc tcctttatgc 2015761 ttttaaaaat gaatggcttt gccatctgcg gcaagcgcag cttctccaat tgcttcagaa 2015821 agcgttggat gcgggtgaat cgtttgcccg acctcccacg gtgttgcgtc cagcactttg 2015881 gcaagacccg cttcagaaat catgtcggtg acatgcgggc caatcatatg aacgccgaga 2015941 atatcatctg tatctcggtc agccacgatt ttgacaaaac cgtcgctttc accgtataca 2016001 agcgcttttc caatcgccat aaatgggaac ttgccgattt tgacattatg cccgttcgcc 2016061 tttgcttcgt cttcggttaa gccgacactg gcagcttcag ggcttgagta aatgcacttc 2016121 ggcacaagcg tcggatcaag cggatgcgga ttgagacctg caaaatgctc aacagcaata 2016181 attccctcat gtgaagcaac gtgagctaac tgcaggccac cgattacgtc tccgattgca 2016241 taaatatgag attccttcgt ttggcagctt tcattgactg aaatcatgcc attttcagta 2016301 acaatatcgg tgttctctag gccgatgcct tcgatatttg cctgtctgcc gatggaaaca 2016361 agcattttct cagcagaata ggtaacggtt tctccgtctt tttccgcttg tatgctgata 2016421 tcgtctgatg tttttgtcat tgtgtcaggc agcacttttg cccctgttat gaactggatg 2016481 ccttttttct taagaagact ttccatttct tttgaaatct ctagatcttc agtcggcaat 2016541 atgcgatccg cgtattcaat aaccgttacc ttaacgccaa aatcatgaag catagacgcc 2016601 cattcgatac cgataacccc tccgccgaca atgatgattg actgtggcag ctcctccatt 2016661 tggagcgcct catctgaagt cagtacagac ttaccgtcca cttcaagacc cggaagcatt 2016721 ctcggtcttg atcctgttgc aatgatcact tgtttcggga tcagcatgtc attttcttcg 2016781 ccatttcccc gctcaacaga aattgttccc ggcagcggag agaagattga cggtccaagg 2016841 atacgtccat atccggtgta cacgtcaatt tttccttttt tcattaaatg atttacaccc 2016901 gctgcaagct tatcaacaac ggcttgctta cgctgctgca ctttttcaaa gttgagggac 2016961 acgccagccg tttccactcc gaattgatcg gcttcacgag ctgtccggta tacctctgcg 2017021 cttctaagca gcgctttact cgggatacag cctttatgca gacatgttcc cccgagtttt 2017081 tccttttcca caacggctgt ttttaagccg agctgagcgg ctctgatggc cgcaacataa 2017141 ccgccggtac cgccgcccag aatgactacg tcatactcag ttgccatggt gactcactcc 2017201 tgtctgtcta ttcaatacga tattgtttgg attgctcttc gccctgcaat actcttagcg 2017261 ccccttgggc aagagactgc agttcatttt cacccggata aactaaaacg tctgaaatcc 2017321 aatctatgta tgatctgata gcagaaacaa agctttttcc gtacgcaagg cctcccgtca 2017381 gcacaatcgc ttcaacttcg ccttttaacg ccgcgctggc tgccccgatt tcctttgcta 2017441 cctgatatgc catggcatca taaatgaagc gggctttttc atcgccccct tgaatcatct 2017501 gttccacttt tactgcatca tttgtaccga gatagcctaa aagtccgccg gtgccaacaa 2017561 gctttttcat gatttcttct tttgtatatt cccctgaaaa acatagatca acaagatctc 2017621 ccgcaggcac tgttcctgct cgttcaggac tgaatggtcc ctcgccgtgc aggccgttat 2017681 tgacatccac cactcgcccg cggtcatgga cgccaattgt aatacctccg cccatatggg 2017741 taataatcat tttcatgttc tcatatcgtt tgccaaggga ggctgccgct ttacgagcga 2017801 cagctttttg gtttaacgca tggaaaatgc ttttcctttc aatttcaggc atgcctgaaa 2017861 ctttcgcaag cactgacatt tcgtctacga caacagggtc gacgatatac gaagggatat 2017921 tcaggccgtc agcgatttcc cgcgcgataa tgccgccgag attagaagca tgctgaccgg 2017981 cgtagccgct tttcaaatcc tcaatcatct catcattcac tacgtaggtc ccgccttcaa 2018041 ttggccggag aaggccgcct cttgcgcaga ctgcatcaaa ctttgaaata ttgattccct 2018101 gttcatgaag cgtttcgaga atatggtttt tacgaaattc atactgatca ataattcggt 2018161 caaatcgctg cagctcttct atgttgtgtc tcaatgtttt ttcaaaaatg cttctttcgt 2018221 tatgaaaaac accgattttc gttgaagttg agcctggatt aattgtgaga atgcgttttt 2018281 cgtcatgtag cactttcata acctccagat caatttctta acgtctgctt aatacactgt 2018341 ggccgttttg caaaaactgg cttcttgagc ggcgcatgcg ttcaatccgt tcctctgcta 2018401 agcggtcagc cgctaaatat gcaggaatgc cgtcacgctg agaaatctca agtacacgct 2018461 cgatattgcc gtaaatgcct tcaacttttt tcaatgcacg ttctgcatta tagccgtaaa 2018521 gctcatctgc cacgttgatg acaccgcccg cgttaatcac gtaatccggt gcataaacga 2018581 tgcccatttc gtgaatttga tcaccatggc gtgtctcttt taattggttg ttagccgcac 2018641 ctgcgatcac tttcgccttc agctgtttaa tggtgtcgtc gttaatagtc gcaccaaggg 2018701 cacacggcgc ataaatatcg cagtcttgtg aataaatgtc atcaggatct accgcacggg 2018761 cgccaaaatc ttcaactgca cgctgtacag attgtttgtt gatatccgta acgattaagt 2018821 ttgctccttc ttcatgcagg tggcggcaaa ggttataggc tacgttccca acaccctgta 2018881 cagcaatggt ttttccttca agagagtcgg ttccgaaagc agctttagct gctgccttca 2018941 ttcctctgta caccccgtac gctgtgactg gggacggatt tccagaagag ccgaaagcag 2019001 gagaaatccc tgtgacatag tctgtctcat catgaatgat atccatatcc tcgaccgttg 2019061 tgcccacatc ttcagccgtg atgtatctgc cattcagtcc ttgaatatag cggccaaacg 2019121 cgcggaacat ttcctcattt ttgtctttgc gcggatcgcc gataatgact gtttttccgc 2019181 cgccaaggtt taagcctgcc gccgcgttct tataggtcat gcctcttgcc aatctgagcg 2019241 catcttcaat tgccgcttct tcattttcat atgtccacat tctcgttccg ccaagcgccg 2019301 gaccaagcgt tgtatcatga atggcgataa tcgcttttaa tccagattgt tcatcctggc 2019361 agaataccaa ttgttcgtaa tcgtatttct ccatatattt aaaaagttcc atgttcgttc 2019421 ctcctaatgt gtgtattctt cagatgcgca tattgccagc gcaatggaat acagtttatt 2019481 ttcagcagag tccgctctgc ttgttaaagc aatcggtgct tttgctcctg taatgacagc 2019541 cgccacgctg gccttggcaa aataaatcag tgatttatat aaaatattgc cggcctcaat 2019601 tgttgggacg agaaggatat ctgcgttgcc cgctacgtct cccgaaattt ttttctgggc 2019661 cgcggcaatt tgtgaaactg cgttatccaa agcaagcggt ccatcaacaa tgcagccttt 2019721 gatctggccc cttttgtaca tttgagctag agcagctgca ttcacggtcg cttccatttt 2019781 agggttcacc gtttcgaccg ctgcaagggc agctgctttt ggcatattgt tccccactgc 2019841 atgggccaca tgaacggcat tttgcaaaat ctgccggagc tcttccagcg aaggagcaat 2019901 attcattgcc gaatctgtca caaacatcag ccggtcaaaa tccggtatat cgaagacagc 2019961 cacgtgagaa aggacacttg ctgaccgaag cccctcctgt ctgttcaata ccgctttaag 2020021 caaaacagaa gtcggcacat tgcctttcat taaaacgtcc gctgttttat gatgcacagc 2020081 acgaaccgct aatttcgccg attcctcagg agtattggca tggacgattt ccacttgatg 2020141 cccttgcatg gatgatgtca gctcgttcag ttttttgctg tcgcccgtta acaagaaacg 2020201 ggcggatagg tgctcggctg ccagctttac agcccggatc acttcctcat cctcagcatg 2020261 agcaaccgca atggtcttat ttttgtgtat cgacgctttg ccgattaaat ctttcagctt 2020321 catctgttac cacctttctt gtttcgactc cgccttttat tatgcaagtt ccatgccagc 2020381 tcttaagggt gctgtcatac caggtatacc gaaacattcg tgcagatgtt tgcgtttatt 2020441 ctgcaaatta ttgcatgcct tcatttgcaa ggccatattt atccattttg taatataaat 2020501 tccgaatgct gacaccgaga gcttttgctg tttttgtccg gttaaaatga tgcttttcaa 2020561 gcgtttgctg gatcaaatgc gcttcaaatt tttctactgc gacagacagc ttttcgcctt 2020621 caatatccgg aaaatcaaaa cctgttccct gatctgtgtc attttctttt tgctcaagtt 2020681 cgaatacagg caagtgatct ttttcaatcc attccatatg cggattcaga aaaatcatgg 2020741 ctcgtccaag gacattttca agctcccgga cattcccagg ccaatggtag gcagataagg 2020801 cgcgcaaggc ttgctgtgag agccctttta cattcctgcc gtaatcccgg ttgatctttt 2020861 ggataagtct gacgctcaat gcttcaatgt cctccaaccg ctgccgcaaa ggcgggatgg 2020921 agatcggata gcgattgatc cggtaataca ggtcttcccg gaatgttccg tccgccatcg 2020981 ccttttcaat atttacattt gtcgccgcga tcactctgac gttgacaggg atcgctttcg 2021041 tgccgcccac tctgacgatt tccttttctt gaaggacgcg tagcaatttg gcctgcatat 2021101 tttgtgtcag ctcaccgatt tcatctaaga aaatactgcc gttatttgct tcctcaaata 2021161 aacccttttt accgccgcgc ttcgctcctg aaaacgcacc atcctcatag ccgaacaatt 2021221 ctgattcgag caggttttca gaaagggctg cacaattcac gcgaataaat ttattgtatt 2021281 tccggtcact ttcgttatgg atggcatggg cgaacagttc ttttcctgtt cctgattccc 2021341 cgcgcagcaa gatggttgcc ggtgttttcg caccgagctt cgcctgctca agcgcaacca 2021401 gcatttgctc gcttttgccg ataatgtcgt caaacgtgta tttcgcttca agcgtgcgaa 2021461 taatttgtct ggcgcgatta agctccgctg tcagcatttt aatttcggaa acatcgtgaa 2021521 tcacgccgac gctgcctttc aaaatcccgt ccacaatcac cggtgctaca ttaacgatca 2021581 cttctttttc attcgggccg accttcattc tgacaccgcg gacaggacgt cttgtttcaa 2021641 gcacctttaa atgcatgctt tcgccttcgg aaatatcagt gtttgcaggc ttgccgatga 2021701 cttctttttc agaaagcccc gtcattttcg tatacgcttt attgattagc aggccgatgc 2021761 cgttttcatc aacgacagaa atcgcctcat cggaggattg aataattgcc tccagcatcg 2021821 tacggacctg ctttaagttg gtcacttcct ctgccagctc gaccgcatca gtgatatctt 2021881 taaacacaca aagagccccg agcagacgtc cgccttcatc aataatcggc agtcttgtgg 2021941 tcacaatttg caaatgatcg cctaacagct gcttctggtt gtattcaggc actcttgttt 2022001 ttaaaatccg cggcatctta gtgctcggaa tcacttcttt tattgggcgc ccaatgactt 2022061 cctcacgttt ttttccgacc attttttcgg ccatatggtt aaagagaatg atttcttcat 2022121 tgatatcaat aaaaatcatt ccatcatggg tggaattaaa aattctgtca tatttatagg 2022181 tttgctcttt tagcatttga atcaggtgct gcttttcttc catcagctga aaaacgatgt 2022241 atgccatttt tcccggcatg acaatggtat cttcatgctt tctttgaagg agctcgtcaa 2022301 acacggcttg atcgccggta gtatgaatga cgatatccgg tttttgttgt atgtaaggtt 2022361 tccaatcaga tgatacggca atcccatact gttctgcttc tttcaatccc ggcgcctcgg 2022421 ggtctttgtc aactacggca atgatatcta tgatggctgt tttaatcaga atatgtaata 2022481 acgccgttcc ccttttgccg gcacctacta tcagtacctt ttgcatcccg ataccccttt 2022541 gtatgaaaaa atttgcacac ctatttattc cgttgcaata atttgcacaa ccctatgtta 2022601 ccacgttttc ttctcttgac aaaatatttt ttccgctgga caataaagga aatgaaaaga 2022661 taaaggggtt ttctgaagat gagccgactt cttgcgcttt taatattagt catccccggg 2022721 gctatttctg ctttaggcat taaactgatg agagatacac ttttcggcca tacaatcaag 2022781 ccattttcag ctctttggct ccaagggttg tcaggattca tcttttttgc gatcggcctc 2022841 tatgtgctgg ccgggttcat tttatacaga gacagaaaac gcaatcaagt cagcccgcga 2022901 ttcagaaaac gatagctgaa aaaaagccgg agaatgctcc ggcttttttt gttgcattat 2022961 tcgtcaggca aaacggtctt ggcaatcgtt ttgtctaacg cttcatagtc ataataagaa 2023021 atcgtatcgt acagttcttt tcgtgtctgc atatcatgaa gtccttcttt ttgtgagccg 2023081 tgctccttca tcaaaccaaa catccgctca caagcttttg ccgccgctcg aagcgaggtg 2023141 acaggatata tcaccatgtg aaaccccata tcttcgaatt catcggcacg ataatatggc 2023201 gttttcccaa attcagtcat attcgcaagg agcggaacgg ggatacgctc agcaaactgg 2023261 cggaattcat tctccgcctg tagcgcttcc gggaaaattg cgtccgctcc cgcctcaatg 2023321 taagcctctg aacgttttat tgcggcatca agcccttcct gcgccctggc atcagtacgg 2023381 gcaacaacaa taagggaggg tgccgcttgt ttaatggctt ttattttttg cgccatttcc 2023441 tttatcggaa ctagctgttt gccatttaaa tgtccgcatt tttttgggag ctgctggtct 2023501 tccatttgaa cggctgctac cctggcttca agcatctccc gggctgttcg ggcggcattt 2023561 aagacaccgc caaatcccgt atcgatatcc acaagcaaag gcagatcagc tgcacgcaca 2023621 agatctttgg cccgttcagc tatctctgcc gatgtgatga tccctaaatc aggcagcccc 2023681 ctgctggctg tataggcagc accggacaaa taaatagcag aaaaaccggc ttctttcgca 2023741 agcaaagcgg ccatcccgtc atgggcgccg ggaatttgaa gaatgtccgg tgctgacatc 2023801 agcttgcgga aacgcccggc aagctcctct tgtgacgatt gcttattgac gatccacgac 2023861 atgaaacaaa atcccccttt tacatgcaga acatgtctac gaattcattt acgcgcatcg 2023921 tttgtaatgt ctcatagctg gtacagcgct cataaatgtg tttgtgctgt ttatcaggaa 2023981 aatgggtttt gagattgtca gaaaactttt ccagcagttt cggcactgct tcctctcttc 2024041 gaaaacgatg gccgagggga aactcacatt ccaccatttc cgtgctcgtt ccatctttaa 2024101 aatgaacctg aacggcattt gagatggagc gtttatcagg cttcaaataa tcctcggtat 2024161 atgttttatt ttcagtcact tccattttat cacgaagttt atctattctc ggatcattcg 2024221 ctgtttcagc ttcataatgc tgtgcggtga tatcaccaaa aagcaaaccg attgctgtaa 2024281 tgtattggag gcagtgatca cggtctgccg gattgtggag cgggcctttt ttatcaatga 2024341 ttcggatagc tgattcatgc gttctgatga caactcggtc aatctcgtca atccggttct 2024401 ttacctgcgg gtgaagaatg acggcggact ccgccgctgt ctgggcgtga aattccgcag 2024461 gataagacac tttaaataac acattttcca tgacataagc gtcgagcgga cgggcaagct 2024521 tgatctcttt cttattgaat aaaacgtctt ggaaccccca acccggtgca ctcaaggctg 2024581 tcggataacc catttcccct tttaacgaca tcagcgccaa atgaacacct ctgctcgttg 2024641 catctcctgc cgcccatgat ttacgcgagc ctgtattcgg tgaatggcgg tatgtcctca 2024701 atgctgcatt gtcaatccat gcattcgaaa gcgcattttt gatttcttct cttccgccgc 2024761 ccaaaagctt tgctgcaaca gcagttgtcg caactttgac aaacagcaca tggtcaaggc 2024821 caactcgatt taagctgttt tctaacgcca gcacaccttg gatctcgtgt gctttgatca 2024881 tcatctcaag tacgtcgcgt accgttaacg gctcttttcc ttcagacagc ctcactcttg 2024941 atacataatc agcagcggca aggattcctc ccaagttatc ggatggatgc ccccactccg 2025001 ccgccagcca cgtatcgttg taatcgagcc agcgaatcat gcagccaata ttaaacgctg 2025061 ccctcacagg atcgagaaca tatgacgttc ccggcacttt gcttccattc ggcacagtcg 2025121 ttcctggaac aatcgggcca agcagctttg tgcattccgg ataccgtagc gccaagattc 2025181 cgcagcccag ggtatccagc aatacatgcc ccgctgttgt atacgcttcg gcactagtaa 2025241 tctctttctc aagcacatag tctgtgattt cttcgataac acgatccgtt ttcggcattc 2025301 taccagctcc tttcatgatt ttgtttgata tcgcgggccc atgtaactga cacggggacg 2025361 gaagagccga ttattggcat gctgttcgat cacatgggcg cataaaccgg acgttctcgc 2025421 gctgaaaaag atcggcgtat ataaaggaat cggtatgccg agcatccaat acactggggc 2025481 agcatagtaa tccaaattcg ggtaaagccc tttttccttc tccatcagcc gctcacccgc 2025541 ttcgcacatc tcatataaac gatggtcacc ggctttatcg cataattgct gcagcgcctc 2025601 tttcatcatg agtgctctcg ggtccatttt tttcatatac acccggtggc cgaagcccat 2025661 gattttttct tttcttttca gttttgtttg caaaagctgc tcaaaatcag atgtcgtttt 2025721 tgcctccaaa agcaaataca tcacagcttc gtttgctcct ccgtgaagat tccctttcag 2025781 ggaagcgaca gccccagtca aagccccata aagatctgaa tgtgtagatg caatgaccct 2025841 ggccgcaaag gttgaattcg gcatctcatg ctcactgtac aggacgagcg accggtcaaa 2025901 aatctgttct tccaatgaag acggcaattt ccctgtcatc atgtagagaa aattcgcact 2025961 gtaggatagg gtttgaagcg gaagaatcgg ttctttctta ttaatgatcc tgtagctggc 2026021 agcagtgagg gcaggcattt tcccaagaag ctgataggcg cgttctttgt ttgcggaagg 2026081 agaccgatca tcaatttgcc gatcatagcc agcaagtgcc gacaggccgg tacgcagacc 2026141 atccattgga tgagtgtcct cagggagcag ctcaagcaga cggagatgat cagcaggcag 2026201 gcttgaggca ctgtttattt tacgttccag cgtttccatt tcactttctt ctggcagcct 2026261 gccctccagc aataaatgga caagctccag atagcttttt gtttcagaaa gttctattaa 2026321 atcatagcct cttatcaaaa tctggctgga ctgcgtgtca agataagaaa tatgagtttc 2026381 tgccgcaatc acaccgtcca accctggaga ataatgctgt ttctcctcca tatcctcaac 2026441 ctccgttttt gcgttttttg tctatcaggt tccgccaagc aaatacttgg aaataatcag 2026501 tctttgaatc tcgttcgtcc cttcataaat ttgcgtcacc tttgcatcgc gaagcaggcg 2026561 ctcaactgga taatccttca tatagccata tcccccataa atttgaacgg cgtctaacgc 2026621 cgcctttacg gctgcatcgg aagcaaattg tttagccata gacgcttctt ttccacagtt 2026681 taggccgcgg ttatgaaggt ctgcagcgtg gtagacaaga tgtcttgccg cctcagctct 2026741 agtcgccata tcagccagct taaatgatat gccttgattg gctgcaatcg gccttccaaa 2026801 ttgcactcgc tgcttcgcat aatcaacggc atgctcaaga gccgcctctg caattccgag 2026861 ggcctgtgcc gcaatgccga tccggccgac atttaaattc gccatggcaa tgtgaaagcc 2026921 atccccctct ttgccaagca aattggcttc aggcacttct gcattatcaa aaatcagttc 2026981 cgtagtattg gagccataaa gccccagctt tctttctttt tttccaacgg taaaaccggg 2027041 tgtgtttttt tcaacaataa aagccgaaat cccgtgcctg ccttgatctg gagctgttaa 2027101 agcaaatgtg atatagatat cagctgctcc gccattcgtt atgaatattt tcgatccgtt 2027161 taataggtat ttgccgttct ttttgattgc tgttgtgcgg aggctcccgg catccgaccc 2027221 cgagtgaggc tccgttagtg caaatgcgcc caaatggtct cctgacgcga gatttggtat 2027281 atatttcatc ttctgttctt cgttgccgaa atacagaatc ggattcgtgc cgactgaggt 2027341 atgaacggag agaatcacgc cgacagccgc gctgattcta gaaatctcat gaattgccaa 2027401 aatataagaa acaacgtccg ctccagcacc gccgtattgt tccggcaccg gtattcccat 2027461 cagtccgtgt ttacccattt ttttgatcag ctgaaaggga aattcgtccg ttttctccat 2027521 gatttccgca gcgggagcaa tttcttttcg tgcaaaatca cgcaccattt ttcgcatcat 2027581 gacttgctct tgggttacat gcaactcggc cacccccgga tggaatagac ttcaggaagt 2027641 cttctcctca tagtcataaa aaccgcgtcc gctctttttg ccaagccagc ctgctttgac 2027701 atacttgcgg agcagcgggc aaggacggta tttggaatcg ccaaggcctg agtgaaggac 2027761 ttccataatt gataaacacg tatccagtcc gataaaatcc gctaatgcaa gcggacccat 2027821 cggatgattc atgcccagct tcatcacttc atctattgcc tccggcttcg ccactccctc 2027881 atacacgcaa tagatggctt cattaatcat tggaagaagc acacggttgg aaacaaaccc 2027941 aggaaaatca ttgacttcta ccgctgtttt ccccatcttt tccgctaatg ccataacatc 2028001 taaggccgtt tcttctgatg tagccaagcc tcgaatcact tctaccagct tcattacagg 2028061 gacgggattc ataaaatgca tgccaataac ccgttgaggc cggtttgtta cagcagcgat 2028121 ttctgtaata ggcaaggaag atgtattgct ggccaaaatc gtatgaggcg ggcaaatgcg 2028181 atcaagtgtt ttaaacatct cagtttttgc cgccatgttt tctgcgatag cctcaatcac 2028241 aatgtccgca tgctctgcct cctcaagtgt ttgagaaatc gaaatgcggt tgattacgct 2028301 cttcacttcc gtctcggtcc tttttccttt ctcagcatca cgggccagct gtttcttcag 2028361 ccgtttcaat cctgcctccg cggcctctgg attcacatca tacatccgca cataaaagcc 2028421 cgcgtcggcg gctgtttgag caattccgct ccccatctga cctgcgccag ctaccatgat 2028481 ttgtttgatt tccattcaaa tccccttttt catcatgttt taatgaacct gcactaagac 2028541 ggcgtctccc tgtgctgccc cgctgcaaat agcggcaacg cccagacccc ctccccgtcg 2028601 ctttaattca taaacaagcg tcatgagaat tctcgcaccg ctcgcgccga tcgggtggcc 2028661 gagcgcgatc gcaccgccat tcacatttac tttttcaaga tcgaaaccta cgattttttc 2028721 acatgtcaaa acaactgaag caaaagcttc atttacttca aacaagtcaa tatcttggac 2028781 agttaaacca ttctttttca ggagcttgtt aatagcaaac cctggcgctg ccgccagctc 2028841 gtgcgctggc attcccgtag ttgaaaaacc aagaattgta gccagaggcc gtttgccaag 2028901 ctcagcagct ttttcctcag acatcagcac gaacgcgccg gctccgtcat tgactccagg 2028961 agcattgccg gctgtgatag aaccgtcact tgcataaatc ggagcaagtt ttgcgagctg 2029021 atccagactt gtgtcacggc gaatcgcttc atctttatca acaacgtttg gttttccttt 2029081 tcgaccgatc cagttgacgg gaacaatttc atcctgaaac ttcccttcat cggcggcctt 2029141 agctgccctt gcatgacttc tcaacgccca ttcgtcctgc tctcttcgtg agattgcata 2029201 ttccttggca gctgtatttc cgtgaacagc catgtgcacc tcgtcaaatg cgcacgttaa 2029261 tccgtcatac accattaagt ccctaagctc gccgtccccc atccgtgctc cccagcgccc 2029321 ggcgggaacg gcatacggaa tattgctcat gctttccatc ccccccgcaa caagtatgtc 2029381 cgcatcctgc gcccgaatca tttgatcaca taaagtgaca gcgcgaaggc cggaagcaca 2029441 gactttattc agtgtttctg acggcacact ccaaggcatt cccgccagac gggcagcttg 2029501 acgggaaggt atctgccctg agccggcctg gacaaccatg cccatgacgt ttccttctac 2029561 atcatctcca gagactccag cctgttgcag cgcctccttc atcacaatgc ccccaagctc 2029621 agcagctttc acctctttca aaactccgcc gaatttgcca aatggagttc ttgcagcact 2029681 tacaatgact gttttcctca tggtttcacc tcattcagaa gatagacagc gcttacaatt 2029741 tctagttgtc ttctatgaat gtatgctttg aaacgggcat gaatgaatga aaaaagaagg 2029801 ctgcgtcaaa cagcctcctt ctaacaacta ttcatttttc agcaatgccg aagccttttc 2029861 tggaaagtcg gtaaacatgc cgtctgctcc cgcttcaatg agacgcttca tatcttccgg 2029921 acgattgact gtatacggcc ttaccttaat caaaccgttc ctcattttct tcagtacttc 2029981 atctgtgacc cctgggctgt ttatcttcgg gtgatagccg gaagccggaa tagacgcgat 2030041 atatcgatct gcctgataaa gcacatctga agttaatact gcccgttcga tatgcggtgc 2030101 aagccgggcg cacagcgcca agctgtcatg attaaacgtg gataggatga ctctgtcctc 2030161 tacattaaat cgcttcactg cctccagcac tttttcttcc attccctcat agcggatcac 2030221 gctgtttttt aattcaatgt tgatgagaaa atcctttttt accgcccacg agagcacatc 2030281 ttctagcagc ggcactttta tatcgctgta cgcttgatcg tgaccagcgg ccgcattcgc 2030341 agtctttacc tcatcatagg ctgtatcctt cacgaatcct ttaagtgatg tcgtgcgatt 2030401 aagtctttca tcatgaatta caacaatgcg tccgtctttc gtcagctgta catcaagctc 2030461 tatcccatcc gctccggctt caattccttt ttcaaatgca agcattgtat tttcgggaaa 2030521 ttgacctgat gccccccggt gggcaaaaat ctttgtcatc gtttcacctc aaaccctaaa 2030581 gttttctcca ttatacttat tttgtcggct ccactctagg attaaggctg tatcaatcta 2030641 ctgatcataa taagaatcaa tgccattgac aatcgcatct gcggcctttt gctggtattc 2030701 ttcacttccc agcttgtccg cgtcagagct gttcgtgata aacccaagct ccgccaacac 2030761 acttggcatt tgtgaatatg taatgacgta aaagtctgat tctttcacgc ccctgtctct 2030821 cgtttgtaag gaagaaacga gctgtgactg aatatcggat gccagacgcc ggctgttctc 2030881 cccttcataa tcagattgaa aatacgtttc tgttcctgaa gctgaagcaa cccctgaatt 2030941 cacatgaatg ctgacaaaaa ggtcagcctg attggcactt gccttagcca ctctttcctc 2031001 caaggtcaga aaatgatcgt cagaccggga tgcaacagga ttggctccct cctcttttag 2031061 tttgtctgtc acatgctctg agacagccaa attaatatcc ttttcaaaga gcccgtttcc 2031121 gaccgctcca ctgtcttcac cgccgtgtcc ggcatcaata tacactgttt tcccttctat 2031181 cggctctgct gcctgtgcac aaggcgcgag cgtcaaagcc aatccgcaca gcgccaagct 2031241 cctccataac attctcaact tactccctcc ggtcacgagt tctttcgcag ctgaatatct 2031301 tccagctgta aagttccatt atccttcttt gtatatttca ccaggacatg tgtctgatct 2031361 ggcagtgatt cacattcatc acgtttatcc ttcggaactt gtatcatggt ttcttctcca 2031421 ttaagagaaa ccgcaatcgt atgaggatca gccgagccaa tgtattttcc ctcttcggta 2031481 aacctcggca ctgagtcatc cgcacttgca acactgcacc ccgaaagaaa gagcgcagta 2031541 aacagcaaaa gaaccgtttg tttcacatga ccacctcttc ctgatgtttg gcttttatct 2031601 ttgaccagaa tggagaattt gtaaagacaa cgcgaatgca ggcgagcaag ttccatgatt 2031661 ttcaaaaggg ctatacgacc cgatcatttc ctgttgttag aaagataacg agcagatttg 2031721 tctatgagga tggctctaat tgaggcgcca attagaaaaa attagcggaa agaagcaact 2031781 ttttattcat tttaaaaaat ttgagaatag ggtgagcaaa tcgtttgacg ggtgggtcag 2031841 ccaagcgtaa ccttttaaag gatatttact ttattgaaag aagttaaagc catgaaaaaa 2031901 ttcgttctgc tgctggcggc agctgtcatc acatgctcca tcggccacca aatcagtggc 2031961 ggctacaaag gccccgaaaa agagcggcca aaacatcact ctgcactcaa gatattcagt 2032021 cggtaaagca gatcaattgc attaattttt acatataggc tagaatatgt gcgaatccaa 2032081 acgaaagaag atgatcaaat gaatcctaag tataagccac tttttgaacc atttacgttt 2032141 aaaagcggcg ttacaatcaa caaccggatc gcagtagcac cgatgactca ttacgcttct 2032201 aatgaagacg gtacaatatc tgaagcggag ctcgactaca tcatcccccg ttcaaaagag 2032261 atgggaatgg tgattacagc ctgcgcaaat gttacaccgg acggaaaagc attccccggg 2032321 cagccggcca tccatgacga ttccaacatt ccaggtttaa aaaagttagc acaagccatt 2032381 caggcacaag gcgctaaagc tgttgtacaa attcatcacg gcggtattga gtgcccgtct 2032441 gagctcgttc ctcaacagga tgttgtgggg ccaagtgacg tgtttgataa cggcaaacaa 2032501 attgctcgcg cattaacaga agaagaagtg gaaaacattg tgaaggcgtt tggagaagcg 2032561 acaagacgcg ccattgaagc cggctttgac ggtgtcgaaa ttcacggtgc aaacggctac 2032621 ttaattcagc agttttattc tccgaaaacc aaccagcgca cggatcgctg gggaggaagc 2032681 gatgaaaaac gattagcctt cccgctcgct attgtcgatg aagtgaaaaa agccgcttca 2032741 gaacatgcga agggtgcatt cttagtcggc taccgcctgt ctccggaaga acctgagaca 2032801 ccgggattga caatgactga aacttatacg cttgttgatg ctttagggga taaagaattg 2032861 gattatcttc atatctcact gatggacgtg aactcaaaag cgcgccgcgg tgcagatccg 2032921 actcgcacac gcatggactt attgaatgaa cgtgtcggaa acaaagtgcc gctgatcgcc 2032981 gtcggttcca tccattccgc tgatgacgcg cttgccgtca tcgaaaacgg tattccactg 2033041 gtcgctatgg gacgcgaaat tctagttgac cctaactgga cggtaaaagt aaaagaaggc 2033101 cgtgaaaagc aaatcgaaac agtgatcaaa ggcacagata aagaaaaata tcatttgcct 2033161 gaaccgctat ggcaagcaat tgtgaacaca caaggctggg tgccttataa agattaatgt 2033221 gcaaagactg ccgaaacgat tcggcagtct tttttccctt tatataaata gtttgtgtac 2033281 acatctaaac agcaaaagaa agagctcccc accaacttcg aaaagaaaat ccaggaaaaa 2033341 cccctcacgc tttcttgctt ttttcttttt cattcgtacg tctccttttt acatgaatac 2033401 gccttactta cgattttgca ggagaaaggt ttcattttat aacggacaca tctagggtcg 2033461 atcatgcttc gtgatcctat aagatgtatg aatggaccaa gagtgcaggt aataccgcca 2033521 tttgctttcc ttacttttca aacctatcct ttactatatg cggatactta atattcttct 2033581 cccatactac aaatgtcccc aaaacaaaac gcctcctatt tatcagcgca aactaataaa 2033641 taaaagacgt ttgatttaat gaccacttaa taagctcatg tttaagaagc cttatgctct 2033701 aacctcagct tatccgcaac cattgcaatg aattcactgt tggtaggttt agcttttgtc 2033761 atgctgacag tataaccaaa caacgaggaa atggaatcaa tgtttcctct gctccatgcc 2033821 acttcaattg catggcggat cgctctttct acacggcttg cggttgtgtt aaattttttg 2033881 gcgatgtccg gatagaggac ttttgtaatg ctgccgagca attcgatgtc attgtatacc 2033941 attgagattg cttcgcgcag atagagatag cctttaatat gggctgggac gccgatttca 2034001 tggataatgc ttgtgatgct cgcgtcgaga tttttcttct ttggttcagg ctggctgctg 2034061 cgtataatac tgctttgcga tgatggcgca cgatgcgtca cactgctggc atttccgctg 2034121 acctggcgga tatggccgac aaggttttcc atatcaaacg gtttgagaat aaagtaggac 2034181 gcgcctaaat cgacggcctt tttcgtgaca tcttcctgcc caaaggctgt cagcataatg 2034241 acattcggct gttttttcag atctgattcc ctcagcctct ctaaaaccgc aagtccgtct 2034301 agatgcggca taataatatc taatacgagc acatcgggat ctttttcttt aaacagcgac 2034361 aggcattcct gtccgttata agcaacgccg atcacttcca tgtcttcctg tccttctata 2034421 tattcactta acaggcttac cagctctcga ttatcatcag caacacaaac tttaattttc 2034481 tccacgtttc ttcctcccca aatgtagtta acaggattca cccttgctac atgtttacat 2034541 tcgacaaaac cgctatatac cctctaaaaa aatcataatc accaatatta gtggcatatc 2034601 tttgttattc tatgtttttc tctgtttttc gactaaaaat gaaatttgac aaacaaggaa 2034661 acgtgaattt gtcgaaaaat cttcttttgt atattttacc gtatgtattc tgagaagtga 2034721 agagggatca ggatatactg atgaacgaat ggatgtgcac gaaaaaaata agctgcgctt 2034781 ctcgcgcagc ttacccagtt gttttgactt gatccgcttg ttttaaaagt tctttcgcat 2034841 ggcgtttcgt taagtcggtt acttcgacac ctgcaatcat gcgcccgatt tccgctacct 2034901 tttcctgctt agagagcggc ttgacacgtg tcgtcgttct gccgtctttt aactccttcg 2034961 caatataaag atgcgtatcg gccatggcag ccacctgagg caggtgtgta atgcacagca 2035021 cttgtgatcc tattgacacc ttatggatct tctcagcaat tgcctgtgcg accctgccgc 2035081 ttacaccggt atcaacctcg tcaaaaatga tcgatgtcac atcctgttgt gaggaaaaaa 2035141 tgctttttat ggcaagcatc acccgtgaca gctctccacc tgaagcgact ttcgaaaggg 2035201 atttcagcgg ctcgcctgta ttggttgaaa ttaaaaactt caccaggtca atcccttgtt 2035261 cagtcagctg aacgggctgg ccgtttacaa gcggcgcctc ttcattgcgt gacgctgttc 2035321 tgaccttaaa ttccgtatca aaagttgatt tttccatgta caggcttttt aattcccgat 2035381 gaatctcatc agccagcttt ttcgcccatg tttttcggat ttgtgacaca tttgccgctt 2035441 ccactgcgac atctttgccg acggagtcaa gctccttttt caagctttga aggtggctgt 2035501 ccctgttttc aatttggtca atctcttctt caattttaga agcatattcc aaaatgtctt 2035561 caacagtggc accgtatttt cgtttcagct gtttgatttc attaagtcgc gtctcaatat 2035621 agttcaggcg ttccggatca aattcaagct catccagcat atttctcatc tgaaatgtgg 2035681 catcctcaag caaatagtag gagttcgaaa cactttcaga catttttttc agcggttcgt 2035741 ttatatcaga tatatcttca agctgcgctg atgccattcc aacccagtcc aatccgccct 2035801 gctcactgcg aagcgcgtta tatgcatttt gcagcgactc atatatcttc tcaaagtttg 2035861 aaatttgctg gcgctcttct tggagctgtt catcttcgtt aagctcaagc tttgccgatt 2035921 cgatttcttc gagctgaaat tgaataagat caagacgatg ggccatttcc tgttcgcttt 2035981 cagaaagctg cttaagcttt ttgagcagct tcacataccg ctggtaccct tcctgatacg 2036041 ttttgagcgc gctttccact tcggccccgg caaacttgtc caaaagctgg agatgatttt 2036101 cgtcttccat taacagctgg ttatcgtgct gcccgtgaat atctaataaa agcctgccga 2036161 tctctcttag tgaagcaatc gtgacaagct tgccattgac acggcaaacg cttttcccgc 2036221 tcgtgctgat atcccttctc atgacgatca tttcgtctga aacgtcgatt ccctgctcag 2036281 cgcatacgcc taaaacagga tggccgctct ccaacagaaa cagcccttca agttcggctt 2036341 ttgcttcccc atatctaaca aattcagatg atccgcggcc tccgactaaa agagaaatgg 2036401 catctatgat gatggatttg ccggctccgg tttctcctgt taaaaccgta agcccgcgtt 2036461 caaaagaaac cgtcagttcc tcaataatgg caaagttttt aatcgatagt tcagctaaca 2036521 aacagcatta cacctcttat ctttgttaga ttttctgtta cagcagttca aggagcctgt 2036581 tttttacgcc ttctgtatct tcaggagtcc ggcaaataat taaaatcgta tcatctccgc 2036641 aaatggtccc catcatttca tcccagtcca aattgtccat cagcgccccg attgcctggg 2036701 cattgcccgg catcgttttc agcacaatca tatggcttgc tgagtctatt ttcacaaatg 2036761 cgtccatcaa tgcccgcttt agctttgaca gcggattgaa acgctggtcc gccggaagac 2036821 tgtatttgta agaaccatta tttgtaggca cttttacaag gtgaagttct ttaatatccc 2036881 gtgataccgt ggcctgcgtt actttgtatc catcctgctt tagcatgtcg accaattcat 2036941 cctgcgtttc gatttcattg cttgtaatga tctctctgat tttaatatgc ctctggcctt 2037001 tgttcatgta agcacctcta tttccaagct tatctgttct tttatgttat atgattctct 2037061 gcacattgta catgaatgca gaaaaaagga ataatagcgc cctattattc cggtacatct 2037121 gctttttttt cttttaacgt cttatgtgct tcttctacaa cgcgcatgat ctcttcttcc 2037181 ggcagttcct ggccttcctg tccctctccc ggccaatgca aatgaaggag aaactcaata 2037241 tttccgtctc ctcccgtgat tggagaaaat gacaagcctt tacagatata gccttcagcg 2037301 gcagaaaaac tgatcattcg cttgagcaca tcagcatgca ctttaggatc tctaacaatc 2037361 ccttttttgc cgacggattc ccgtcccgct tcaaactgag gcttaactaa agccatgcag 2037421 tcgctgcccg gtacgagcaa agtccttagg acaggcagga tgagccgcag tgaaataaag 2037481 gacacatcaa ttgtggcaaa ctccggcatg ccctttgtaa agtctgccgg tgttgcataa 2037541 cgaaagttcg tccgttccat cacgacgacc cgttcatcct gtctaagctt ccatgcaagc 2037601 tgattatagc ctacatccac agcgtatgac tgtttagctc cattttgcaa agcgcagtcc 2037661 gtaaaaccgc cggtggagga gccaatatca atcataattt tatctttgac agagacggga 2037721 aattccttca acgctttttc gagctttaag ccgcccctgc tcacatacct cagcgggttt 2037781 cctttgacag ttaacggaag gtcgcggtca attttttctc caggcttgtc caagcggttt 2037841 tcgtttgaat agacgatccc cgccataatg gctcttttgg ctttttcacg cgtttccgcc 2037901 agccctcttt ccactaataa tacatctaat cgttctttct ttgacgtcat gatccaattc 2037961 ctttgtgtgt ctttggtggc atcagtaatc taatacgatt tgccacctgc tgttttgtca 2038021 gtccaatttc ctcaagaagc gctgttacac ttccgtgttc aataaaccga tcaggtatac 2038081 ccattctgtc aatcggagta tgatattcac cttgatcatg agcgaattct aaaatcgagc 2038141 ttccgaaacc gccttctaag accgcttctt caattgttaa aattggcaag ccttctttta 2038201 ggatactctt catcatcttt tcatcaatcg gcttaataaa acgcgcattc acaacgcgca 2038261 cggaaaggcc ttctttctgc agctcttcgg ctgcttcaat cgccatttcg attgttgtgc 2038321 cgaatgttaa gatgacagca tcgttccctg gacgcagcac ctcccacgta ccgatcggaa 2038381 tcgttttcaa ctgttcatcc atttttacgc cgagtccgtt tccgcgcgga aaacgcattg 2038441 ctatcgggcc ttcgtcatag ctaagtgctg tatgaaccat gtgctggcct tcattttcgt 2038501 ctttcggcat cattaagacc atgtttggaa tgtggcgcat aaacgcaata tcaaacacgc 2038561 cttgatgtgt ctctccatca gcgccaacga gtccagcacg gtcaattcca ataaacacat 2038621 tagcgttttg gcggcagatg tcatgaacaa cttggtcata tgccctttgc aggaaggttg 2038681 agtaaatcgc caaaaacggc ttcataccct gcattgccat agctgcagcc attgttgcgg 2038741 catgctgttc tgcgattcct acgtcgaaca tccggtcagg gaattccttt gcgaagcctt 2038801 caagctttga accgacaggc atagccggcg taatggctac aatgcgtccg tcctcgcgcg 2038861 ccattcgctg cacagttccg ctgacaagac cgctccacga aggagctgcg gctttcggct 2038921 ttacaaagtc accggtatta attttatatg gtccggtacc atgccatgtc ccaatcgtat 2038981 cggtctcagc cggtttgtac cccttccctt ttttcgtaat gacgtgcaga agaacagggc 2039041 ctttcgtttt tttggcgtat tgaagattct caatcagctc atgataagaa tgtccgtcca 2039101 ctgggcccaa atacgtaaaa ccgagctcct cgaaaaacat tccggagacg agcatgtatt 2039161 tcaggctgtc tttgacccgt tccgccgtgg cggcaagctt gcccccaact gccggaatct 2039221 ttttaaataa gtattcaagc tcatctttga cccactggta tttccccgca gtgcggagcc 2039281 gtccgagcat agagtgaatg gcaccgacgt ttggcgcaat actcatttca ttatcattaa 2039341 ggatgacaat catgtctttt ttctcgtcgc cgatgtggtt aagggcttcg agcgccatac 2039401 cgccggtcag cgcgccgtca ccaatgatcg gaataatata ttcatccgtt cctttaatat 2039461 cacgggcagc tgccattccc atcgcgcctg acagagaagt cgagctgtgc ccggtttccc 2039521 aaacatcgtg ctcgctttca ctccgctttg gaaatccgca aagccctttg tactggcgaa 2039581 gcgtcgcaaa ttcttttccg cgtcctgtca gcagcttatg gacatacgac tgatggccta 2039641 catcccataa aaatttgtct ttcgggctgt taaattcctt atgcagggca acagtaagct 2039701 ctacgacacc taagtttggg ccgatgtggc cgccggaagc ggataaactt gtaattaaaa 2039761 actgacggat ttcatcactt aatttctcta attcatcaat ggacatgttt tttaaaaacg 2039821 acgggtcctg tattgataaa agatccaaag cggatcaact cactttcagc atgaatttct 2039881 gcaatgatac atgtcttttg catgccgagc tgacaataat ctcagacata aaaaaagaca 2039941 aacgcgcttt tccttttcat ttttcatata aactgcttac attttaccat acctcgtgca 2040001 gccgcttcaa attaggatcg ttttagtgat ctcttgccgc aattaaatca caaagctcat 2040061 ataaaaggtc tttttgaaga gagagtccgc cgatcaatcg cttcgcctct tttatatgaa 2040121 catccaattt atgtttggcc ccttccaatg aaagaagcga cgggtatgtc gatttgtcat 2040181 ttgtggtatc cgagccgaca cgtttgccga ttttctcttc actgccttct aaatctaaaa 2040241 tatcgtctct gatttgaaat ccgattccaa tgtggctgct gaaggtacgc agtgtttcaa 2040301 tgtcttcctc aggcgcatca gccaaaatag caccggcgat tacacaaaag ccaaggagct 2040361 tggcagtttt ccgttcatga atggattcga gctcttcaag cgtgacttgt cggttttccg 2040421 cttccatatc agctacttgc ccaccgacca tgccttcggt gcctgccgct gaaatcagtt 2040481 cattcacaag ccgcaggcgc ttttctgctg acacctcgtc tgacacgtgg gaggtaatca 2040541 gcttaaagct ttctgtgagc agcccgtcac ccgctaatac tgccgtcgct tcaccaaaca 2040601 ctttatggtt tgtcggcttc ccgcggcgca aatcgtcatc atccatgcat ggaagatcat 2040661 catgaattaa cgaatacgtg tgaatcattt cgacagcaca gcccaccgga atgccgtctt 2040721 tttcgctttt tccatatgca tttaaaacag ccagtacaat cagaggccgc aaccgctttc 2040781 cgccggcctg tagagaatat agcatagatt tctttaatga gtccggcata tcaagctttt 2040841 ctgtatagac agaaagctga ttttcaattg tttttttccg gtccgccaga aagctcgtta 2040901 atttatttgt caccttcgtc ttcctcctga acactgaaag gtgccagttc gccgtcttct 2040961 tttaaaatga agtccatttg cttttcgact ttttgcagct tttcatggca catttttgac 2041021 agagccatgc cttcttggaa atagttaatg gcttgctcta gaggcacatc tccctcttca 2041081 agctttgata caatgctctc aagccctttc atcgcttctt caaatgtcat gttttcattt 2041141 tttttcacgt ctgtcatttt tcttcccctc tcttttctaa tacttcacag gtcagcacgc 2041201 catccttcag cttgatttca agccggtcct gctcttctat ttgactgaca cttttaatga 2041261 gtttatcttc tttataagcc aagctgtatc ctctttccat cacttgaaga ggacttagtg 2041321 cattcagctt gccaagaacg gtttgaaatt gggaatgcag ctgcttcatt tggatattca 2041381 tattttttct cagctgattt gtttgttcct ggtatcgtgt tctcgcttgt ttcagctgtt 2041441 catgaggatg caatgcctct aatctgtacg tttcacgctc cagctgtctg cttttccgat 2041501 ctaaaagagc ggtcagctgt gcttgaaact gctggtacgc gaggtcaaac tgctgctctt 2041561 tttgcgcata caaacgcttt ggaaaacgaa aggcatagga cgattgcagc gtttgtatcc 2041621 gttctttttt ctggccgaga tgctgctgca ttgctcttgt cattctgact tccgctgttt 2041681 ttgtccgttc gattaaatca gtggtatgag gcacagcaat ctcagctgct cctgtcggcg 2041741 tcgcagctct gatatcggcg acaaaatcac taatcgtaaa atccgtctca tgtccgactg 2041801 ccgatataat cggaatattg gaagcaaaga tggcgcgtgc tacaatttct tcattgaatg 2041861 cccacagttc ttctatcgaa ccgccgcctc tcccgacaat taatacgtcg caaatctctt 2041921 tttcatttgc ctcttcaatg cgcgtaacga tggatctgct cgcattttca ccttgtacga 2041981 gcgctggaag aacaatgact tttacaaggg gatatcttct ttttagagtt gtaataacgt 2042041 ctctgacagc ggcacccgtt ggagatgtca caaccccgat tgtggctgga aatgcgggga 2042101 tttgtttttt gtagcggtcg tcaaataaac cttctccggc aagcttcttt tttaattctt 2042161 cgtacgctaa ataaagcgct ccaaccccgt caggctgcat ttctttggca tataattgat 2042221 agtttccgct cggttcatat acggaaattc cgcctctgac cagcactttc attccgtttt 2042281 caggtttaaa aggcagacgc tcgctttgtc tcgcgaacat caccgactgc attcttgcgt 2042341 tttcgtcttt taaagtgaaa taaatatgcc ctcgtgtgtg tatctttaca ttcgacaatt 2042401 cgcctttaat ccaaatattt tcaaggtgag gatctacatc gaattttcgt tttatatact 2042461 ttgtcagcgc tgagacggtc acatacgctg cttcacccat gtctaaaaac tcctctccta 2042521 agcattcctg caccataact aaagaaaacc cgccctggct ttaggagcct gaagaagcgg 2042581 gtatcgtgct catattcaag gcgggtaaac atttcgcctg tgaatatctc caattatcta 2042641 tgataacgta cgtttcgcag atttaacagt attatgcgca agcatcgtga tggtcatcgg 2042701 acctactccg cccggaaccg gcgttatgaa ggacgctttt tcctttgccc cttcaaattc 2042761 aacgtctccg caaagctttc cgttttccag acggttaacg ccgacgtcaa tgacaacagc 2042821 gccctctttg atctggtctg cactgatgaa gttggctctg ccgactgcca ccaccaggat 2042881 gtccgctttt ttcgtatgtt cagtaatatt ttctgttctt gaatgacagt aagtaaccgt 2042941 cgcgttttca tttaataaaa gctggccgac aggtttgccg acaatgttgc ttcggccgac 2043001 tacaacaacc tctttaccgg aaaggtcaat attggttttc ttcaaaagct caacaattcc 2043061 atgaggcgtg caaggaagaa acgtatcttc gccaagcagc attttcccta cgtttaacgg 2043121 atgaaaaccg tctacatctt tatcagggga gatacgttcg atcaccgctt tttcagaaat 2043181 atggtctggg agcggaagct gaacgagaat gccatgaaac tcagggtctt ggttatattg 2043241 atcaataatg gaaagcagtt cagcttctgt gaggctgctg tcaaattgat cgagcttgaa 2043301 attcattccc attgtttctg ccgctttttt ctttcctcgc acgtaagagt gagaagcagg 2043361 atcatctcca atcaaaataa ccgccagtcc gggagtgacg ccttgctttt taagctcttc 2043421 tacctctttt gccaattgtt cgcgtttttc tctagccgtt tcttttccgt cgatgattgt 2043481 tgcagtcatt ttctttcctc ctatgattgt tcaatatcag atttaatgtt agaaagaacc 2043541 ccgtttacaa actttgtcgc tttgtcatca ccaaaccgtt ttgccagctc aatcgcttcg 2043601 ttcatggaga cattcaccgg aatgtcttcg gcatatgcca tttcatatgc tgccaggcgc 2043661 aaaatcgcac ggtcaacatt ggcaatccga tcgagcttcc aattcaccag atgcttggag 2043721 atcatttcat ccagctggtc ttggtgttcc aataccccgt gtacaagctg ttcaaagaaa 2043781 ggatctgttt tttcttcatc cagtgcgtgt tctatggctt cattcactgc aatatcgctg 2043841 acatcaattt gaaatagtgc ctgcaaagct ttttctcttg ctgttcttct tttcattttc 2043901 tttctccttt gatcctcttt atccgcttgt cgttaagcca caaagagatc ataacatatt 2043961 tttttcgtat ccgcatattg aaatcaaggt ttttttaccc tattaccgaa tattttcaca 2044021 caccttaata tgattattcg gatttcacgt tcatgaagaa actcggctat gtaagccggc 2044081 tttcttcatg ctttgaaata aagggtaacg tgtaaaaaaa ccaaagggcc gccctcccct 2044141 tggtttcgtg ttaagccatt tacatttctt cgtcgatttg gacttcttgg gcttttgtgt 2044201 caaattgaat gccgacgatg tgaatattga tctcgttaat cgaaagagac gtcatattta 2044261 ataaggtttg acgaatgttt tcctgaacgg atgctgcaac tttcggaatc gaaacgccaa 2044321 atgtaacgac acagtataca tcgatcgtaa ttccgtcatc cgccaggtcg actttgacac 2044381 ctttgccatg attcactttg ccaaagcgct caacgacgcc tgtcgcaaag tttccgcgca 2044441 tttcggcaac tccatcaact tctgatgctg caatgccggc aatgacctca atgacctccg 2044501 gtgcaatctc aaccttaccc aaatgcgtat cttcgtgatc cattttaagc aagctgttgt 2044561 ctttcattca attcacctcc gtaaaaatta tgagcccatt acatcatatg tttctaaaaa 2044621 tttcgtatta aactctccgc tcacaaatgt ttcgtgttca agcagtttta aatggaaagg 2044681 gattgttgtc tcaatgcctt cgatgacgaa ttcgctcaat gcgcgcttca tgcgggcaat 2044741 cgcttcatct ctcgtttttc cgtatgtgat tacctttgca atcatgctgt catagtacgg 2044801 tgggatggaa tagccagggt acgcagctga atcgacacgg acaccaagac cgccaggagg 2044861 caggtacatt ttaatttcac caggtgacgg catgaaattt ttgcttgggt tttctgcgtt 2044921 gattcggcat tcgatggccc agccttcaaa ttcaacatct tcttgcttga ggctcagttc 2044981 cattcctgaa gccactttga tttgttcctt gatcaggtca gttcccgtca ccatttctgt 2045041 gactgggtgc tccacctgga ttctcgtgtt catttccatg aagtaatagc gctgttcatt 2045101 gtagtcatag ataaattcaa ctgttccagc acctgtatag ccaaccgctt tggcagcctt 2045161 taccgctgca tctcccattt gctccctgat ttctgaatca agggcaggag atggtgattc 2045221 ttccaaaagc ttttgcaggc gtctttggat cgagcagtcg cgttcgccca aatggatcgt 2045281 atttccgtag ttatcagcaa gcacttggat ctcaacgtgg cgaaaatctt ctatgtattt 2045341 ttcgatgtat acacctggat tcccaaatgc agttgccgct tcctgctgtg taatcttaat 2045401 gccattaatc agttcctctt cagtgcgggc aaccctaatt ccttttccgc ctccgcctgc 2045461 ggtggctttt ataattacag gatacccaat ttcattagca agcgaaaccg cttcttccac 2045521 attttctata attccctgtg aacccggtac gattggcacg ccggcctgtt tcatcgtttc 2045581 ccgcgcaacg tcttttgttc ccatttttga aatggcgtca gcgctcgggc cgacaaacgt 2045641 gacattcact tcttcacata attcagcgaa atcagcattt tcagctaaaa atccgtatcc 2045701 cggatgaatg gcgtccgtgc cagtcagctt tgcaacactc acaatatttg taacgtttaa 2045761 atagctgtct tttgatgctt tcggtccgat acaaaaagct tcatcggcca tttgaacatg 2045821 aagggcatct ttatcagctt ctgaataaac agcgacagtc tcaattccga gctctctgca 2045881 ggctctgatg attctgacag caatttctcc tctgttggcg atcaatagct ttttaatcat 2045941 gttcagtctc cttactccgc ttttacaaga aatagaggtt gtccgtattc gaccagctgg 2046001 ccgttttcta ctaatacttc aacgatttcg cctttcactt ctgcttcgat ttcgttgaaa 2046061 agcttcatcg cttctacaat gcagacaact gtgttttcat ttacttttga accggctgtt 2046121 acatacgggc cagcttccgg tgatgaagaa gcataaaatg ttcctaccat tggtgaagtg 2046181 attttatgca gattctcatc ttgctttggt gcttcttggg caggtgccgc tgcttgctgc 2046241 gcttgcggct gaactgcctg cggagcctgt gcttgtacag gtgctgccgg tgcctgctgc 2046301 atgacttgaa ccgtgcctgc ttcgtgtttt ttcagtttta aggatacacc ttcattttca 2046361 tatacgaatt cgtcaattgt agactcgtca attgctttaa tcagctcgtg gatttctttg 2046421 atatttaaca ttcaatcgca ctcctatgta tgaaatttct ttttttatag gttactacta 2046481 aaagtacata ctatgttcat cttacaggag cggacttttg aattcaactc taatatgaca 2046541 gcaacgcaaa aagcccgctt gtttagcggg cttttttccc tcattcttat ttagagggtt 2046601 caaatgtgac agcgacatct ttcattgttt tgatttcttt tgccacaagg tctataatgg 2046661 ctgtcgcctt cgatttagag tgtttgtctg atttgactgt aatattgatt ttatctcctt 2046721 cagcattaac aagcgcatcc tcgtaacctt gtgttttaat cagcgtttcc agctgttttt 2046781 ctgttccttc cacttcactg agagccgtca ttttatcgta tgcttcgctt ttctccttgg 2046841 ctgttgcatc atcgcttgac acaatggcat tcagctcttc tctttctttg cttctggcat 2046901 cttctaaatc aagacggtac gttgtaaaca aatcatcatc ggctgtttcc gtaacaacag 2046961 ttcctttttc actggcttca gcggatgttt ccttgtctgc tgatgaatct ttcgttccct 2047021 ttgttccatc ttcttttcct ttttcagttt ctgtaccgct tttttccttc gtgtcttgct 2047081 tggcaggcgc tttttcagtt gcgacctctc cgctgtcaga cgcgcttttt tcactttgca 2047141 tctgcacggc gtttttgctt tccggcgaca tgatatagta gacgcttaac accacgacaa 2047201 gactgagcat tgttaatagc caaacggttt gttttttaag catttatgaa tcctccttta 2047261 tttttttagg ggcaaccgca acccggtggc ttggaacatc caggacccgt gtcaccgctt 2047321 cgataatggt ttgttttatt tgaacgttgt ccactccttg agcaacaacg agtacaccgc 2047381 gtatatcagg ttttttcgtt tggacgacga caggtgtttc tttatcgccg tttttgatca 2047441 tgacgatttc ttcctccgat gattggtctg taacgcttct ttttccgcct tctttgtcag 2047501 tttcttcagt ggttgtattt ttgtttgatt tgtttttttc gtatactttc agcgacgttg 2047561 catctacatt cacgacaacc gagacatcgt ccacaccaat gattgtttca agaatttctt 2047621 tcagttgatt ttcgtattct ttttcatagt catcgatcga gtctttaggt ttatcagatt 2047681 ttgaggcttt aaacacttcg gctgttttct ctttgctgtc tgcggaatgt tgtgatgata 2047741 cggccgttat cgttttggcg ttttcagttt tctcaggtga agaaaacagc tggctgacaa 2047801 gcataaagga aactccgaga acaaaaacga atagaaagta atgatatttg gtcagcttcg 2047861 gcttttcgcc gtccttcgtt tgtcccggaa gaaactgctt tttcaataca ttccataatc 2047921 cgtttttatt cattgccgac actctccccg ccttccatat gaaccgtaat tttctcactt 2047981 ccgatttccc aaatgtccgc gagctgcgtt tgtatctgtt tggcttcttt ttgttcggct 2048041 gcttcttttg ttacgtatgc atgatctgta tcaatgtgga ccggcgcgac cgtttggacc 2048101 gttttttcag aagacggggc catatacacg ctgattgttt taatatcctc ttctgaatct 2048161 accttttctc ctgccgtgag tttgatgcgg cctactttat attcatcatg actgaatctc 2048221 tcctccgctt tcttttttag ttggacagcc atttcttcta gaatatatgc gcgctgggaa 2048281 gcttgtattt ctattttttt tgaattgatt tgatttttta tgtcggcaga ctctgactgc 2048341 ccgttttttg tgaggtattc aaagatgact tcggggtctg tcttgaaaag tttaaaaatc 2048401 ggcgtaagca tgacgacaat caagagcagg ctgactacca tttttgcgta cttttgcatg 2048461 ctggagctcg gcagcagcat atcaatcaca attgcaaata ggataaacaa cacgatggtg 2048521 gtaagccatt ccgttaaaaa actcatttgc ctgcctcctt catttcatca tcatcgtgag 2048581 gtttccggct gtgattatga cagtaaggct taaaaaaaac atgagagaca caatggcgag 2048641 agctgcaaaa atataaatga cgcttttgct gatgacgtcg aggcaggtga tgacgggccc 2048701 gcctcctagc ggctgaagaa tcgcggctgc cagcttataa ataaaagcga gggaaagcac 2048761 tttgattgcc ggaaatgccg caatacagat caaaatagcg acaccgagaa tccctaccgt 2048821 atttttcagc agtaaagagg cgctgattac tgtatctgtt gcgtctgtaa acattcggcc 2048881 aagcacagga ataaaatttc cggttataaa tttagccgtc ctgagcgtaa tgccgtctgt 2048941 cactgcagct gacgctccct gaacagagat gacgccgaga aagatggtaa gaaaaacagc 2049001 cagtgctccg atggcgatat ttctgagcag gttagccagc tgcgttactt tgtattgttc 2049061 agtcatcgtg ctgacaatgc tcagaatcgc tgataaaaaa atcagcggca tgacgatatt 2049121 ctgaatcaag agaccgctcg tgttcatcag gaagaggata acaggatgaa agaaggcagc 2049181 agatacagct ccgcctgagg aagccaaaag cgccaagagg agcggaatga gcgccaggat 2049241 aaagctggtc atcgtctgaa tcgcctcagt tgcatagtta attgccacat gaaagctatt 2049301 aagcgcaagg ataatcagca ccatgtacac aattgagtaa gcgaccttac tgacggtgct 2049361 ttgctgaaaa gcattttgca aaagctgcag aatgacgcaa aaaatcgtga gcaaaatcaa 2049421 tgtgcccagc agctttccgt tggcaagcac ttcatgaaac aaataagaaa agagagcttt 2049481 cagccattct tgcggtgaga atgatttatc gccattgata aactccatta agctgccttt 2049541 ttggctttcc ggcagcagtc cgccgtattc tgtcataatg tcattccaaa attccccgat 2049601 cttatctgtt tcaagcgagg ctgctgtcct ttccgctaat tgctcggctg tttcagcatg 2049661 gtcttccgtt tgttctgcat taccagctgc ttgtacaatt tctgcacggc ctgctatgat 2049721 cagcacggcc aaaagcaaaa cccattgaaa gcgcttcaat ctaccgcctc ctttcggtta 2049781 tgacatagaa ggtataagtc cgagaatcgt ttcgataatg acggttaaaa taggcacagc 2049841 cattacgagt attaaaattt tccccgccaa ttctattttc gaggcgatgg ctccttgacc 2049901 ggcatctttt gtgagctgtg ccccgaattc agcaatatag gcgattccga taatctttaa 2049961 aatggtttca acatagacca tgttgacatt tgcattaatc gcaatttttt ctatcattcg 2050021 aataatgtcg tagatttggt ctaccaaata aagaaaaatg gcacatccgg caaaaacgac 2050081 gattaaaaac gcaaaagtcg gcttttgttc ttttacaatt aaagaaagga aggtggcgat 2050141 cagccctaaa cctacaattt gaacaatgtc aatctgcaag cccccctatc cttggaataa 2050201 aaacacagct tttatctttt taaataggtc atctacaatc gtggcgacca taaataaaat 2050261 atagataaaa cctaacagcg tcacccactg agcatattct ttcttgccca tctgatccaa 2050321 tatcgtgtgt aaaaaagcga ccacgattcc cactccggcg atttgaaata tgacattcac 2050381 gtctactccc attttatttt tgctcccctc acgtttacat caatagaaga atgagtaaca 2050441 agcccgctaa aaagcccaaa ctttttatca tcttttcgtt tttcgcttgc gcctgctcag 2050501 catccgcttc tgaggcttcc aaatgtgtca gcgccagctt gatgtgcttt tgctgagaga 2050561 ttcgatcatg aatcccaagc gtctcgccaa actgcttcag cacttcgtat tcgctttttt 2050621 tcaaagacag ggtgtcccat accttcttta agctttgctc ccacgccgtt ttcgcggaat 2050681 cacttccctt gtccagctga tcactgaatg cggaaaaaag agttgaaaca ggctgtgcga 2050741 gctgtttggc aatctgctgt gaagcagtat gaagcggtgt atggccgtac atgatttcag 2050801 cctcgaggga ttgaagcgcc gcacgcagct ggcggatttg ccgcggccgt tctgtataaa 2050861 tcttcgccat ctcaaaacct gtccatgttg tcgctaccac aatgaataca gcgcccagca 2050921 gcttcagcat gttttcacgc ccgtcgtcct agacagcaca tttccgtctt tgtcataaat 2050981 ttggctcact gtgcccggcc cttttgctct tgataattcc aaatagcggt caaaggctct 2051041 ttcttcccac aaacgcttca atgaaggccg cttcatcagg tcggatatac tccagccatg 2051101 cgccgatacg attactgaaa caccggcatg cagcgcctcc agaagtgcat ctgtatcttc 2051161 catacgcccg atttcatcga caatcatcac ctcagggctc atggatcgaa tcatcatcat 2051221 cagcccttca gcttttggac aggcgtctaa cacgtcaatt ctctgaccaa attgatgctg 2051281 cggaataccg cgaagacatc cggcaatctc tgaccgttca tcgacgatcc ctgtctttac 2051341 gggcagcatg ttttttttgc cggtgcttga gagcctcgca aggtcccgga gaagtgttgt 2051401 tttgccggtt tggggcggtc cgataatcag cgtattcagc cagctgtttt gatataagta 2051461 tggaagcagc ggctccgcaa tccccagctt ttgccgggca attcgtatat taaaagatgc 2051521 gatgtcacgg aggcctttca cacctccgtt ttccgtaatg actctgcccg ccagtccgac 2051581 tctgtggccg cctctgatcg tgacataccc tttcttcagc tcttcttcaa gtgtatacat 2051641 actatagttg ctgagccggc tcaggatcag atgggcatcc tcggccgtgc ccgcatagga 2051701 caaataaaca ggttgtcctc ttcgaatcaa ttcaacaggg cggttgatcc gaattctgac 2051761 ttcttcgatt tccagccatt gttgttccgg tatttcagaa agggcgtttt tcatggattc 2051821 agggagaacc tcagcgattt cattcaacag agcctcctcc tttctaccga ttggcttctt 2051881 taaaatgtat gatgtgaggc agactttatg acaagcctct ctttatttat gaacacccgc 2051941 caaaatcaag acaacacccg taaaaatcag aatcagcttt gcatacgaaa gctgcccggc 2052001 aatttggtag attccgacag tcattgtaat gataaaaatc aacggaccga caatagcgag 2052061 aatgctgtta accacaaccg ccttccggac atcgttggtc acaagcatga caattgctgc 2052121 cgtcagctca atcatagagg ataaaactcg taatcccgcc attgttaaaa cagtagaatt 2052181 gatatttcca agtaaaaatt tcatagcact ctcccaacct cccatttttt tatatgatat 2052241 gctctagctt gctgaagtag tcttgtcatt ttcgtataaa agaaagattc tgtttttggg 2052301 cacaaaaaaa gcctgctccc atttgggaac agacttcttt ttttctttct atgctcttga 2052361 aacgtaagaa ccgtctgatg tattgacaac aagtgtgtcg ccttcattca caaagaacgg 2052421 cacgtttaca acaagcccgg tttcagtttt cgcaggtttt gtaccgcctg acgctgtatc 2052481 acctttaata ccaggttcag tttcaacaac tttcagctca actgtgtttg gaagttcgat 2052541 accaagtgtt tcatcctggt acatcatgat atgcacagac atgttttcta gcaggtattt 2052601 taattcttct tcgatttgag ttgcgctcag ttcaagctgc tcataagaag aagtatccat 2052661 aaatacgtgc tgatctccgt ttgcatatag atattgcatt gttttggttt cgatttgcgc 2052721 tttcgctact ttttcaccag cgcggaatgt tttttcctga atcgcgccag tgcgaaggtt 2052781 gcggagttta gagcggacaa atgccgcacc ttttccaggt tttacgtgct ggaagtcaac 2052841 gacgcgccaa atgccgccat ctacttcaat tgttaatcct gtacggaaat cgttaactga 2052901 aatcatgttt aatgtcctcc tatattccaa tcacaaaata ataagttctt ttggggaatg 2052961 ggtgattgtc cggttgccgt tttctgtaat cacgatgtca tcttcaatgc ggacaccgcc 2053021 tgtttctggt atgtaaatgc ccggctccac tgtgaccacc atacccggtt caaggatagc 2053081 tgaagatctg acggataatc ccggcgattc atgaacttcc atgccgagcc cgtgcccggt 2053141 tgaatggccg aaatagtcac cgtagccttt tgcagcaata tgatcccttg tgagggcgtc 2053201 agcctctttt cctgtcattc ccggcttaat atgtgcgacg ccaagcgcct gagcatcaaa 2053261 tacaacctga tagatctcct tcaattgatc actgggctga cctacagcga ccgtccgggt 2053321 aatatcagaa caatatcctt tataataagc gccaaaatca agcgtaacaa ggtctccgct 2053381 ttcaatcagt ttgtcactgg ccacaccgtg cggaaggctt gaacgaaggc ctgaggcgac 2053441 aatcatatca aaagaagagc tgtctgctcc ctggcttctc atataaaact ccagctcatt 2053501 ggcaacagcg atttcagaaa tgccgggttt cataaacgtc aagatatgtc tgaaggcatc 2053561 atctgcaatc ttcgcagctt cctctaatat cttaatctct tcactagact taatcaagcg 2053621 caacttttcc acggattcag ccacaggcac taattcggca tcactgataa cggcgctgta 2053681 tgaagcgtaa gtgccatatg tcatgctgtt ctgttcaaag ccgagacgct tgatgccaaa 2053741 cgattcaaca gtgtcggcag tggtctgaat caagctgccg ccatgttcaa tgatctcaaa 2053801 accctttacc tgaaccttcg cctgctcagt ataacgaaaa tccgtaataa acgctgcttt 2053861 gtcacccgat ataacagcca aacccgccga acctgtaaac cctgtcatat agcgtacatt 2053921 agtgttgctt gtaatcagca tgccgtcaat tcccagctgt ccaaacaggt ttcttaattt 2053981 ctctagcttc atcttgattc tcccccttgc tggcttaata agtagcgaac agcaagcttg 2054041 tagccttcag ctccaagacc gacaatctgc cctttcgcaa caggagcgat aaccgactga 2054101 tgcctgaatt cttccctggc gtataagttt gataaatgca cctctaccac aggaagactg 2054161 atgcttgaaa cagcatccct gatcgcatag ctgtaatgac tcagggcgcc ggggttcaga 2054221 acaatcccgc tgtattgctc ctcagcctca tgtatcgcat ctatcaaatc accttcgtga 2054281 ttagactgga agaaagtgag ctggatatgt aaggcttcag caaactgaaa aagatctgtt 2054341 tcaatatcgg tcagtgtctg gcggccgaat acttcaggct cacgactccc aagccggtta 2054401 acattcggtc cgttcaaaat caaaaaatga ggcacacaat ctctcctttt cgcgagggtt 2054461 tctcatgtaa aaaatgttca cttctcgtga acattttatc atactggaaa aggattatac 2054521 actattctct atgcattccc agcgcacgtg caagcttttc cgaattcagc tcattgtatt 2054581 caaatgaaat agaatacccg acaaacagcc cgtaaagcaa ataaatgcaa atggtcgtaa 2054641 taattgtatc tgatgtcagt tcggtcaccg tgcgcacatc tggaaaaatc ggattaaaaa 2054701 caaaaaacac gagcagccaa agcaccaagc cgtataaaat acccggccac attgttttta 2054761 aacgtttcaa tagaagaaaa taaagaaatg ctgcgccaat tgaaattact ccaatcaaaa 2054821 tgatgctgat taccgttccc agcccatgtt ttttccactc tccgagtaca aacggctgca 2054881 atatcatatt cgggctgatt tcggaaaaat gaaacaaata tgcgatataa gcaacgaaac 2054941 tccaaagtac gcctccgcaa aaacctgttg ccgccaccct gccggccatt gaaacaggcg 2055001 gcttttgctt ctcattcaat tcttcatttt gttctgtatc tttttcgctt gtcatcatgg 2055061 cacctccagt taaagtgtgc ccaaaaaatg aaatgtcaat aaaaaagctc acactttttg 2055121 gcagctgcga gtaaaatttg aaaataacgg gtataatgca tgtagaaaaa gcaaggctat 2055181 ggcaattttt tcagcctgtc aatctagagg tttagcgctg tttcctgtac aatagagtga 2055241 aaggaaatgg ttagcaatcc taaagaaata ggcaggttga taatatgtca aaacataaag 2055301 ttccgcccgc ttacggcggg caggctgttg tggaaggcgt tatgtttggc ggaaagcatc 2055361 attacgttac agccatcaga agaacggatg gaagcattga cttttttaag cttccacgca 2055421 aacacaaccc gaaactgaac atcgtgaaaa agataccgtt tttacggggg atcgcggcca 2055481 ttatcgaagc gagtgcaaac ggcacaaagc atttgaattt ttcaagcgaa cgttacgggc 2055541 tcgatccatc tgaagacgag acacttgagc aggaagaaaa aaaatcctct gggctgtcta 2055601 tgtatctcag cctcgcagtt ataggcgtcc tatcattttt gttcagtaaa ttcgtattta 2055661 cattggttcc agttttctta gcggaactga caaggccgat tttttccttg aacacagcgc 2055721 aaatcgcgat tgaaagcctg tttaagttga ttttgctgct cggttacatc tattttttgt 2055781 ccatgacacc gcttattaaa agagtgtttc aatatcatgg agccgaacat aaagtcataa 2055841 actgttatga acagaatttg ccaattactg tggagaatgt ccaaaaccaa tctcggcttc 2055901 attaccgctg cggatcaagc tttattttat ttacgattat tgtcggcatg tttgtttatt 2055961 tactcgttcc gacagatccg ctttggctgc gtgttataga tcgtgtcgca ctgataccgg 2056021 tcgtgcttgg tatatccttt gaagttctgc agctgacaaa caaagtgcgt gacattcccg 2056081 gtctgaaatt acttgggtac ccgggacttt ggcttcagct gttaaccaca aaggaaccta 2056141 aggatgaaca ggttgaagtt gccatcgaaa gctttaacga acttctcaga ctcgaagcat 2056201 tgtctgagca aaatcagaag ccttctcaca acgtcatcta aaatccgttg ccctgctatt 2056261 actttcggag gtggacagtt atgaatcatc gtgtacaacc tattattgct gtattaattg 2056321 cgctgggagc gttcggtttc ctctatgtgc tggtaaccaa tcccggagaa atggcaaaaa 2056381 tggcggtaac cgtcatcgtg gcaggtatca ttatttattt tattgtgaaa tatgtaatga 2056441 atcgaaatgc gggcagcgaa ggagcagcct tcaaaaaagc ggcgaaacaa tcacggcgcc 2056501 ggatgaaaga acaaaaagca aaacaccgcg ccggacataa gggacgtgtc agccacctgc 2056561 gaagcgttcc gagcgccagc aagcctaagc cgatgattct caagaaaaaa agccagactc 2056621 agctgactgt tatagaaggg aaaaaaaata aaaagaaaaa cagagcgctt ttttaatagg 2056681 tccactgctt taaaaacagc tctgtccgtc ttttacctag ctcaatcagg gctagttttt 2056741 tttgttgtgt taaatgaaaa tcagtggcca ttacgtcatc aacagggaga aaaatgatat 2056801 tttgttcata gcgtgacgca atgtgccttg cgtcatgagc atccttcatc gtttcaaaca 2056861 gggcgccgaa cagttcaaaa gcgttgcgga tatttttttt cggacgctct ctttcacgcg 2056921 gcgcaagcgt gacaccgatc acagggcgct ttctttcctt tgaaaacagc cagattggaa 2056981 aattgcttaa cacgcctccg tcgacaaccg tggcggtgcc tgtgtccgtt tttaatttta 2057041 tcggttcaaa gaaatacgga atgctgcagc tcattctgac cgctctggca accgggaaca 2057101 tatctggatt taacccgtaa cgggccaaat cgtccggcaa aacaatcatg gtgccgtttg 2057161 tcagatcaga agcaataagg cgcagagacc ctttctgcaa atcgccgaaa acccttatgc 2057221 ctttcgctct taacagatca gcaatccatt tttctatcgt atcgcctttg tataagccaa 2057281 gacgccagta gatggacacc cactggagca tctttaaggg gagaaatgag tacctctgat 2057341 ccagcaattt ctctccgtcc acttcttcaa ttaaagcgtg gatttcctta ctggtgtaac 2057401 ctgacgcaat gaaagcggca ataatggcgc cggcgcttgt acccgcaact cttttaaagc 2057461 ggaagccttt ttcctcaagc acttcataag cgcctgcgag cgcaatgcct tttactcctc 2057521 cgccggaaaa cacaccgtca atatacatct cattccctcc ccctccatcc gatcgtttat 2057581 taccatttta agaaaacacg cgaagaaata gaccaacgaa tgacgggtgg cgtcagcgta 2057641 tcaaaaaaga cggcctcctt cgagaccgcc tttttactga ttatgatgtt ctgttttctt 2057701 ttggattgat ttcagatctt ttttacgggc atcatcttct tcaaaatatt gaacaagatc 2057761 cccgatgcga tcaatactgt tccagcttaa atgatgttcg attccttcga catcgttata 2057821 tattttctct tcatcaacac caatgattct taaaaactgc tcaagcaatt catgtctgta 2057881 taccagccgt ttgcctattt ttttcccttt agacgttaac acgagaccgc gatatttttc 2057941 ataaattaaa tattcgtctt tatctagttt ttgaaccatt tttgttacag aggagggatg 2058001 gactgccaat gcttccgcga tatcggaaac tcgtgcatat cctttttctt caatcagcat 2058061 ataaatctgt tcaatataat cttccatact tggtgttgtc atcgaaaccc tcccaaaaag 2058121 caccttaact ttataaacca ttacaagttt acactaatga acttgaaaaa acaaggatgc 2058181 tccgcgggtc aaaagccctg tttaccgctt ataattccat tcatctgaag cgtactttgt 2058241 ttcagccaag tgatgaacaa aatcaagctc ttcctgagaa agttcatatg gctccaaatg 2058301 aatgttaaga cctgtttcaa atccttcttt aaaggcttta cgagcctcat ccatcgtcac 2058361 ccgcttttcg atgagttcat taatggcaac cgctttattt ttgaaattgc gctgcatccg 2058421 ctctcttact ctttcacttg gatataagaa cagatcgaac agcttgtcct catctaaatc 2058481 aagaagaatg gagccatgct gaagaatcac acctttttgt ctcgtttgcg cgcttcccgc 2058541 caccttgcgc ccctcaacca ctagttcata ccacgaaggc gcgtcaaaac aaacagatga 2058601 ccgcggattt tttaagcttt ctttttcttt ttcagttctc gggatggcaa agtaagcgtc 2058661 cagaccgaga tttctaaagc cttgaagtat gccttctgaa ataacccggt aagcctcagt 2058721 aacagtcgcc ggcatctcgg ggtgctcttc cgaaacaatt acgctgtatg tcagttcctg 2058781 atcgtgcagc acacctctcc cgccggtcgg gcgtctgacg aatccgagat tatatttatg 2058841 tactgcttca aaattgattt cctttttaat attttgaaaa taccctacag aaagtgtcgc 2058901 cggattccag ccgtaaaaac ggataaccgg ggggattttc ttttcgctgt gccaatataa 2058961 aagcgcttca tcaagcgcca tattgaatgc aggacttgca ttgcctgagt ctataaaccg 2059021 ccaagtttct ttttgcattt taagaccttc cttaccgttt taatagaatc agtttatcaa 2059081 actgtcggga aaatgaaaaa tattttagtt ccattataga tgacaatcac gctgtgcttt 2059141 actataatag tatttgtcga aaacggctct atgaccttgt tttatgaagc agggttttga 2059201 ttttatatgc taaaggagta gaatcacatt gtctaatatg atcgttttga ttatttttgc 2059261 tgcatttatc atctatatga ttgcttcata tgtctatcag cagcgaatta tgaaaacact 2059321 taccgaagaa gaattccgcg cgggttaccg caaagcgcag cttattgatg ttcgtgagcc 2059381 aaatgagttt gagggcggac atattttagg cgcccgcaac atcccgcttt cccagctgaa 2059441 acagagaaaa aatgagatcc gtacggacaa gcctgtttac ctgtactgcc aaaacagtgt 2059501 ccgcagcgga cgcgcggcac aaaccctgcg caaaaacggc tgcactgaga tttacaacct 2059561 aaaaggcggc tttaaaaaat ggggcggaaa gattaaagcg aagaaataaa gcaaacagct 2059621 gtctggtaga cagctgtttt tatttatctt tcttccgcct cgtatctgag cactgggtgt 2059681 ctcgccgctt ttgtttcatc cattcttttt acaatcgttg tatgcggggc ctcctgaaca 2059741 agctccggat tctcctccgc ttcttttgcg atttgaatca tagcatcaat aaacgcgtcc 2059801 agtgtttcct ttgattcggt ctctgtcggc tcgatcatga tgcattcttc aacattaagc 2059861 gggaaataaa tcgtcggcgg atgatagccg aaatcaagga gccgttttgc aatatcaagc 2059921 gtacgcactc ccagcttttt ctgccgcttc cctgataata caaattcatg cttgcaatgg 2059981 cggtcaaacg gaagatcgta ataaggcgcg agttttctca tcatataatt ggcgtttaac 2060041 actgcgttct cagtaacagc ctttaatccg tcaggcccca tggagcgaat atacgtatac 2060101 gctctcacat taatgccaaa gttgccgtaa tacggcttca cacggccgat cgcatgaggg 2060161 cggtcataat caaacgtaaa gcgcccttct tttttgacta aaactggctt tggcaaataa 2060221 ggaatcagat cttgttttac gccgacaggg cctgagccgg ggcctccgcc gccatgaggg 2060281 cctgtgaatg ttttatgcag gttgaggtgc accacgtcaa atcccatatc accaggtctc 2060341 gccttgctta aaacggcatt taaattagcg ccgtcataat acagtttccc ccccgcttgg 2060401 tgtacaattt ccgccatctc tgtaatctgc tcctcaaaca agccgagcgt gttcggattc 2060461 gtcagcataa gagctgcagt ttcttcattc actgctcttt ttaaatcctc taaatcaaca 2060521 agcccttttt cattcgattt caccgtaacg gtttcaaagc ctgctactgt tgctgatgca 2060581 ggattcgtcc catgcgcgga atcagggaca atgaccttcg tccgcttgaa atccccgcga 2060641 gcttcatgat aggcacggat catcatcagc cccgtccatt cgccgtgcgc tccggcagca 2060701 ggctgaagcg taacctcatc cattcccgtt atttcttcaa ggtgtttgct taaatcatat 2060761 aaaagctcta atgcgccttg caccgtgtct tcatcctgaa gaggatgaat cgcagcaaaa 2060821 ccaggaatac gtgcgatttt ttcattgatt ttcggattat atttcatcgt gcaagaaccg 2060881 agaggataaa aaccggaatc caccccgtga ttgcgtttgg acagcgctgt ataatggcgc 2060941 atgatgtcca gctctgaaac ctccggcagc gctgcgtctt cgtcacgaat ataggtgtct 2061001 gacaagaggt cccccaattc gatttccggt acatcgagct ccggcagact atagccgatt 2061061 cggccttctc ttgaaagttc aaaaataagt gcctggtcct gattactcat ggcgatcccc 2061121 caattcctga atgagtgcgt caatttcttc ttttgttctc agctctgtta cagcaatcag 2061181 catatggcag tccagctctg gatacgtcaa cccaagatca tatccgccaa tcatgccttt 2061241 tgccagcaaa cgcttgttca cagctctcac cggctcatcc agtttgatga caaattcatt 2061301 aaacatcggc ccgtcaaaca taacagtaag gcctgctttt tttgcttctt gctttgcata 2061361 gttggctttt aagagatttt ggcgggctat atcttttacg ccgttttttc cgagagcagt 2061421 catggccact gatgctgcca gcgcatttaa agcttggttc gagcatatat ttgatgttgc 2061481 tttatcccgg cggatatgct gctccctggc ttgcagggta agcacaaagc ctctttttcc 2061541 gttttcgtct tccgtttgtc cgacgagacg gcccggcacc tttctcatta attttttagt 2061601 aacggcaaaa aagccgcaat gcgggccgcc gtatgctgaa ggaatgccga aaggctgcgc 2061661 atcaccgacg acgatatcag actgaaactt gcccggcgga gtgagaagac ctagcgccag 2061721 cgggttggct gaaacaataa acatggattt cccttgatga gcgataggct caatatcctt 2061781 tagcggctcg atcctgccga aaaaattcgg gtactgaacg atcactgcgg ctgtgttctc 2061841 gcaaacggtt tggcgcaatg catcaagatc cgtaacgcca tccgcagcgg gtacttcaac 2061901 aacatcaata tactgacctt ttgcgtaagt tttcagcacc tctcgcgatt caggatgcac 2061961 ggtttttgac acaacaattt ttttcttttt cgtgtggcct gaagcaagca ttgctgcttc 2062021 tgccaaggct gttccgccgt catacatcga ggagttggcg atatccatgc ctgtcagttc 2062081 acagatcatc gtttggaatt caaaaatagc ctggagctct ccttgtgaaa tctctggctg 2062141 ataaggcgta tatgcggtat aaaactcaga gcgcgaaatg acatgatcca caatgacagg 2062201 ctgatagtgg tcatatacac ccgctcctaa gaaagaagcg tattgtacgg tatcacgatt 2062261 tttagaggcc agctttgtca gttctcttgt taattctgtc tctgatttcg cttttttgat 2062321 ttgatgctct tttttatatt tgacgttttc cggtatatca gcaaataaat catcgatgct 2062381 gcttacgccg atagtagcaa gcatctcctg tttatccttt tctgttgcgg gcaaataacg 2062441 gtgcttcatg tgttgtctcc tctctccaag aaaaaatatt agcgtttata aaatggtgtt 2062501 ttgacaacct ttgctttcac taattttttg cgtatctcta catctacaac agtcccgatc 2062561 tcactcgttt ccgaatcaat taaggcaagg ccgacgtttt ttcctaatgt cggtgactgc 2062621 gtgccggttg tcacctttcc gacagacttg ccattttgga aaacctcata tccgtgccgc 2062681 ggtatccctt tttcaatcat ttcgagaccg acaagtttgc gcttcgctcc gttttctttt 2062741 tgttcactca atactgactt accgaaaaag tcagactcct ttttgtgctt tacagcaaag 2062801 cctatacctg cttcaatcgg tgtaatatcc cgggtcagct cctgaccgta gagcgggagc 2062861 ttcgcttcaa accggagtgt atcacgtgca ccgagaccgc atggaatcaa tccgtatgca 2062921 tcccctgcat cgatgatttt tttccaaata tgcatagcat catcactgcg gcagtaaatt 2062981 tcatacccgt cttctcccgt atagccagtg cgtgaaataa gtgctttgcg gccgctgata 2063041 tcggcttcat caataaacgc aaacggcttt aatgcagaca catccgcatc tgtcagattt 2063101 tttaagatcg cttctgcttt cggtccctgt acagccaaga gcgcgatttg atctgactga 2063161 ttgtcaatct gcacatcacc tgctgcatgt tctttcatcc aagccaagtc tttatctata 2063221 ttagaagcat taatgacaag cagatagcgg ttctctcctt tttgatagat aagcaaatca 2063281 tcgacggttc cgccatccgg gtaacacatc gctgtatatt gagcacggcc tggcgttaac 2063341 gcggaaacat catttgtcat caatctttgc aaaaaagaca gactgtcgtt ccctgacact 2063401 tcgacttctc ccatatgaga tacatcaaac aaaccggctg cagttcggac agcctcgtgt 2063461 tcttttttta tagaagaaaa ttgaacagga agctcccagc ctccgaaatc aatcgttttt 2063521 cctccatatt ccttatacag gtcaaataac ggcgttcttt tcagcatcta attcctcccc 2063581 tttatcaacg gcgcagctaa aaaacataca aaaaaggaca gagaaacacc tcatgtaaaa 2063641 tgaaggttct ctgtcctggc acctgaaagt ttactttgca tacgcaaaga cgtccccttt 2063701 ggtggtttgc gcatccgcac aaacactctc cagagttgcg tcgagcaaga gttcttttgc 2063761 ctgagagatt cactccgcag tttgctcctt cggcgcctgt atcccgaggt tttcggtcag 2063821 gtctctcccc ttgctgtcat tcgctcatat tttcatgctg ttatggacat actatagcaa 2063881 tatcttacat caaatacata ctcatatcct accatcatca ctatatgctg ggcaacagca 2063941 atttgggcag atttttctta tattattcat cttaagaatc gaagaataag aaaggcggtt 2064001 tcaaagcaat gaatacagaa atgatctacg atgcaaaatg gcctgaagaa tttgctgaaa 2064061 gactgaaaaa cgatggccct tgggcaaact gggaactgta caagctctct gcagaaatcc 2064121 agaaaacatt agcaattcca gagtttgaag gcttacgggc tcctttatat ctgccttcct 2064181 ttacgccgct cccccaccag cttgaagtgg cgcaaaaagt ggttgaaaaa atgaacggga 2064241 aagcgatttt agcagatgag gttggtctcg gaaaaacggt tgaagctgga ctgattctaa 2064301 aagaatatat gattcgcggg ttagcaaaaa aaattttgat ccttgtgccc gcttcccttg 2064361 tgtcacagtg ggtcaaagag cttcaggaaa aatttttgat tccggctgtt gaacaaaaga 2064421 aaagctatgt gtgggagcaa tgcgatattg tcgtctcatc aatagacacc gcgaagcgct 2064481 cgccccatcg agaaatcgtt ctgtctatcc catatgatct tgtcattatt gatgaggcac 2064541 acaaactgaa aaatagcaaa acgaagaact atgaatttgt ccggaatctc gtaaaaaaat 2064601 attgcctgct tcttaccgcg acgccaatcc agaaccgtat cgaagagatt ttcaatttgg 2064661 tgtccttatt aaaacccggc catttaggca gtcagaatca ctttcaggag gagttcgcca 2064721 agaagaaatc cagtttagaa gcgcatgaac atttaaaaga tcttgtgaat aaagtcatga 2064781 tccgtaacag gcggcatgat acagggctga attggaaaca gcgccatgtt gaaacagtgc 2064841 cgattcaatt ttctccatca gagcaggcgc tttatgatga aatttctcgt ttgaaggaca 2064901 gtatcaataa accagccagc atgttctcga ttatgacctt gcaaagagaa tgctgttcga 2064961 gcagagaagc ggtatatatg acgctgaaaa agatgcttga tcaaaaagag aaacaagcac 2065021 ctgccattga tgaggatacg atttcagttt tgatagatcg catcaatcaa gtgacacaaa 2065081 actctaaagc gcttcaagtt gttgacttga tcaaaaagat cgacgataag gtcatcattt 2065141 ttacagaata ccgcgcaacc cagatttatc tgcagtggtt tcttcagcaa aacggcatca 2065201 gttctgtgcc gtttagaggc ggatttaaac gtggaaaaaa agactggatg aaggatcttt 2065261 tccgcggaaa aatccaagtc cttattgcaa ctgaagcagg cggtgaggga attaacctgc 2065321 aattttgcaa tcacatgatc aactatgacc tgccatggaa cccgatgcgg cttgagcaaa 2065381 gaatcggaag aattcacaga ctcgggcagg agcgtgacgt gcatatttat aacatggcga 2065441 caaaacatac ggtggaagag catattctaa agcttttata tgaaaaaatt catttgtttg 2065501 aaaaagtggt cggtgaactt gatgatattt taacgaaaat tcaagtgaac aattttgaag 2065561 agcaccttca tgacattttg tatcactcag caacagaaga agaaatgaaa ataaaaatgg 2065621 ataacttaac ctcatttttg tcttataaaa aacagctgcc tgctgaaaaa agaggatctt 2065681 agcctgtaag gaggttttat tagtgagaca gcaagaggtt cacgattttc tgctgcgttt 2065741 ttttcaagca aacagctgcc aaatcgtcga tcaaggctta ggctatatga cagtgcagct 2065801 tacagttgaa atggacaaac aaatcatgaa ccgccctttc tactggcatt ggcgcgagaa 2065861 gacaggcggt gatccgaatc caatgaaaat cacttttatt acagataaag aaaatgcgcc 2065921 aaaagaccta gatggtgaat ttatatattt tggggccccg cgtctttttc aaatattcaa 2065981 agctgttaaa caaaatggga gatttaccag aatgtatgag aaaattgaat cagccggagc 2066041 taaagtccca cttcagcctt ggcttggtat aaatgtcacg atttcatacc agtccgacat 2066101 gaaaaaggat aagttattgt cactaggtct tcacctagtc tctggaacga taattgaaga 2066161 ttttcaaagc aagctgaccc agttttcact gacgtctcaa atatgtgact attgcttcac 2066221 catttcacct atgatcaaac cagaaagcgg acttaagcgt atggaaaact atatttccaa 2066281 atccgctatg caggagccgt ccgactgggc ggaacaggcg gttaacaggt ggaagaatga 2066341 tatgacattg cttgataagt tttacgagca tatagaagaa aaaccagaag aataccatct 2066401 agaaaaacag gcgctgaaaa ccttgtatca accaaagata tcagttgaaa ttgaaaatgg 2066461 cggattgttt tatctgcaaa ataatatttc aagctaactt ttttaccatt cgacatcatt 2066521 ctcgtttttt ttgagaaaat acgattataa taaaggtata ttggaaaaaa attctggtga 2066581 tttaatggca aatgacttcc agagactaat gaagcataca ataagtcatg gccggactgg 2066641 ctgaaataca taaacaagta ttttaggagg agaaactgca tgaagaatgc aaaacaagag 2066701 cactttgaat tggatcaaga atgggttgaa ttaatggtgg aagccaaaga ggcaaatatc 2066761 agcccggaag aaatacgaaa atatttactt ttaaacaaaa agtctgctca tcctggtccg 2066821 gcagccagaa gtcataccgt aaatcctttc tgaatgtgct ataatatcac aaggaaggtg 2066881 atgacattga ttggccagcg tattaaacaa taccgtaaag aaaaaggcta ctcactatca 2066941 gaactagctg aaaaagctgg ggtagcgaag tcttatttaa gctcaataga acgaaatcta 2067001 caaacgaacc cctccattca atttctcgaa aaagtctccg ctgttctgga cgtctcggtt 2067061 catactttgc tcgatgagaa acatgaaacc gaatacgatg gtcaattaga tagtgaatgg 2067121 gagaaattgg ttcgcgatgc gatgacatcc ggggtatcga aaaaacaatt tcgtgaattt 2067181 ttagattatc aaaaatggag aaaatcccaa aaagaggagt agtgcctgag cagaggcact 2067241 aactcctctt ttgtcaataa ccatcgagac ggcccagtat atgaatactg ggccgtctct 2067301 tttttttgct gttattaatt tttatcctcg ctatgcgcga gctcgtcttg ctcagtattg 2067361 ctcatttttt caatttttta gaaatttttg ggattgttat gtgagaattt aaatgcatat 2067421 cccattatta tttggtaata ataaacaaag aaagggtgac agcatgatga tcaaacaatg 2067481 tgtgatttgt ctatctcttc tcgtctttgg caccacagcc gctcacgcag aagaaacacc 2067541 gcttgtaacc gcccgccaca tgtccaaatg ggaagagatt gctgtaaaag aagcaaaaaa 2067601 aaggtacccg ctcgcacagg tactgttcaa acaaaaagta tgggaccgta aaagaaaaga 2067661 tgaagcagtg aagcaatacc atttaactct gagggaaggg tcaaaagaat tcggcgtttt 2067721 tgtgacgatt tcatttgatc cttatagcca aaaggtcaat aaaattgcca tattagaaga 2067781 atatcaataa ggtcctccat tttttgaagg accttattcg tttatttgcg gttatttttt 2067841 ccgtttcagc caaagtcgga agccataggg taaaataccg aaccactgct gggaaacagg 2067901 cgtttttgtt tctttccgca cctcttttcg ttcttttcgc tcatctctcg gagtatctat 2067961 atatttgaca aattgctgcg tcatatattt aacataatca ttcgttttca cgtgatcacc 2068021 tcatcattca attattatga gtgttgtctc acatgacttt ttttataccc tttacactgt 2068081 tttattctgt ccatctcagc agttttttct gtttttggtc aaacacgatc tgtgcagttc 2068141 tttctgttcc cgaatccgtt gacactctta agttgatttc tttttgttct tttatcgatg 2068201 tatcatgaat gtaataagaa acccgtccat atagaaattg ctgcgtaccc tcctggcctt 2068261 tccgttcctc tagaacatgc cgaatcgaaa gaagcacccc attttgaagc aaattctctc 2068321 ctatgtataa ctcttttgtt tccttctcaa acatgcagcg tgaaatatat tgagcagcaa 2068381 caaagttcac gattaacagc acaagcgctg acacaaaaag aacagctgga taaataaacc 2068441 ctcttgtacg atacattcac ccccctccta aatacgaata gactggaaaa gcagtttgat 2068501 acactttttg gtcttcactc tcaattttca gcaaaacaac accattttca atatcagctt 2068561 tcatggcagt aatatgatct aaaatcggaa catgcccttt gccatccact ctttttctta 2068621 tcattgaatg ataaatgtca aaacggatgt cttgtccgga aagattggtg cagattaaca 2068681 cgctcccatg ctcggctgtc ttaactgcct gtgattcctt gcattcattc atcatctgtt 2068741 ctatcgaaat catccattcc tgctgtgtga aaccgtcatg ttcctgctgt cgagacaaaa 2068801 acagatggat aatcgcagct aacgatcctg atatgagcaa aaagactgag agcgaaaata 2068861 atacgttaag aagcgtgtag ccattctgtc tgcaaaatgc tgaggcaaaa tgatttttct 2068921 ttataagctg cggctttgat acatacgttt tgatattcgc cctcctcctc ccacttcatt 2068981 gcatagatat gattgttctt tgtaatcgtt tttgacgcgg ctccttcacc actcatgaca 2069041 tatttgctaa tgctctcatt catcatctga tagccaattt ctcgtgattc cgccattttt 2069101 tcatcagcca tcagcttgtc ccacaagggg acgactgtca gcagcacaaa cagccacagg 2069161 cttagcgcag acattgtttc tattgtagaa aaacctttat tttctctcca cattgactct 2069221 cccgctccct agataaactg ttatgtcata aacggcatgg ccttttactc gtatttttcc 2069281 gcctgcattc gggtgccctt tctcattaaa ttccaaacgg tcttttaatg tcagcagttc 2069341 tatagaaagt cccgttgcat acggacgttc aataaccgta tcaccaatga ctaattgata 2069401 ttctttttta tgaaagagaa tttttgttct ttgttgacgg gaaatagcag tctgctgtgt 2069461 gagcataata tcatttttca gctgacttgc tgcctgtcgg acagctgtat tgtcataagc 2069521 aggaggaagt gtagtgaaga cggccaccag gaggatagag gcaaggctta acacaagcaa 2069581 actttctaaa agggtaaacc ccttctcctc gtttaattta atgttcaacc ttaacttctc 2069641 cgccggtgat gataatgcgc ttaccatttg gacagacagc atcctttttc acatagccct 2069701 ctgactgtaa atcggcaagg ctcggagttt gtccttcatg atcaagctca aatgcagtca 2069761 tttgtgcctt aaccatgttt tgtaagcctt cacagccctt tttttgaatg gtttgattat 2069821 gtttcgtgac gttcggtatc gtaattaaaa gcaaaatcga aataataaag agcacgatta 2069881 acatttcaac aagtgtaaat cctttctcat tcatcagcct cttcctttca catttgattc 2069941 atcatctgat acataggcac aagcatagat aaatacacaa gtaagatcat cgctgcaaca 2070001 aatccataaa tcattggctg aaggatgcct gtccattttt gcgctttgtg ttccagccgc 2070061 tgtaatatga attggctgta tgtgaaaagc tcccgatcca atcggccgct cagctggccg 2070121 tgagatatga cttttgataa atcagtttca taaaaaaggc ttccacaaat agcggattca 2070181 attgactcac cggcttttag ccgttcaatc aattgttcag cctcgcagcg gtagaaaggg 2070241 agaaacgttt gatgtttaaa tgcattaagg ctgtcataaa ttgagaggcc tgattttaaa 2070301 aggctgctta gctgcaaaga aaaaaagtag ctgttaaaca gctttacaag ctttccaacc 2070361 aaaggaatcc tgatacaaat cagcatttgc cgggcaggtg attttttctt aaacacaagc 2070421 caataataaa tcccgatacc tgctgtaaaa agaacaagca aaatgatcac aagatcaata 2070481 tgctgaaaaa aagcaaaaag catatcggtt gaacgtgagg tttccatatt catcgattga 2070541 tagataccgg aaaactgagg aatgatgatg gactgtaaca tataaaacat gacagcgacc 2070601 gtaaagatga ggaaaagcgg atagcgcagc actcttttca gctggtctgc ctgtgcaatt 2070661 tttcgttcca gcagctctcc gctctggatc attgaagcag gcagttcacc atgtgtttca 2070721 gcaaaataac aaatacctac ggcttcctta tgaaatgaca aactctttag tacttgataa 2070781 aacggagccc cttccctcaa acaagtgacc gaatcagtca agtcagccgc ctgcctctta 2070841 ttcatctgaa gttccatcag gcgtaatcca tccagaagtg tatatccgcc cgcagtcatt 2070901 tcaccgagcc tctttaataa cctggcttga tcctttaaca accagacttt tctaatcttt 2070961 ttcatgataa acccaccggt catagttgtt tgtcgttaaa tagccgagcg caattccttt 2071021 tctgataatt tgacgaagcg tttgatattg gtaatttgca tgatttcctt ttgcctcctg 2071081 gatacattgc tgaagatttt tcccgtatag aagctcataa acgctagctc tcctagtatt 2071141 tcgtgactgt cggcaataca ctgatgaaca tccgttttca caaaacgggc aagccaaatc 2071201 aaccaagcgc tgagccgcta ttgcaatgac agtctgttcg atttcattca tattgatacc 2071261 gaattcaagc agtctgtaaa ttgcgccctt tgcgtctctc gtatgaaggc tcgttagtac 2071321 cagatgtccc gtcatcgctg cccgcaccgc aatttcagct gtttccgcgt ctctgatctc 2071381 acctaaaata atcatatcgg ggtcatggcg caaaattgct ttcagacctg cggaataagt 2071441 tacaccggct ttttcattca cctgaacctg aagaacatct tcgtcccttg tttcaacagg 2071501 gtcctctaat gtgacaatat ttcgattaaa gtgttttttt gcatattgaa cgagagagta 2071561 taatgtggta gtcttccctg aaccagtcgg cccggtaaaa atgagcatgc catgggaatg 2071621 ttttaaaaac gagagtaatg tggctcctgt cttcggaaat agcgacaatt tatcaatcga 2071681 agggatattg tattggggca tcactctgat cacgaggctt tcttcattaa ttgtgggcag 2071741 cgttgacatt cttaaatgaa catttccctc tttcaacttt aacgtaagcg aaccgttttg 2071801 cggctttcgc ctttcaccta tatccattgc tgaaagaaat ttaaaatgtg aaatcagtct 2071861 tacgcactct tcttttttca tgtccctttt tttcagcaag gcatgatcga cccgaaaatg 2071921 aatgatagcg tcccgctccc tcggcacaat gtgaatatca gaagcctttg ttagatatgc 2071981 ctcttcaatc aagtttttgc ttaccttttc tattgaatcc aatttgattc cctctccttt 2072041 caacgcatat tgtagaaaaa gaagaaaagg taatcaaaca gggaaaacgt gattttgtga 2072101 gatgttatat gctgaaaaac caattctttc tggcaagaaa aaagactttc aactgaatgt 2072161 acccctgtca ttataatttt ccctataaat aaaaaagcag acatggtcac catgcctgct 2072221 agattccatt ttcattatgc tgttttcgct tattgaccag tatctttctc aacggaaaga 2072281 tcgcctaatg caacaatacc ggtcatttgg tcattttcaa gaatcgataa actgcggatt 2072341 taatgctctg tcataagccc cttgacatcg tatccggtca ccctgatatg tctggtgaaa 2072401 aagcggggca cgctgcacaa aatatgaaac atcctataga gtccgccttt ttcgaggttt 2072461 ctttttcttc ttccgctcct gcagcatatc tcccgtccag cctttttttc tcaaatagag 2072521 atagatcaga actgtagatg tgacaatcaa taagagggaa aagagatatc cgtatttcca 2072581 attcagttcc ggcatcactg aaaagttcat cccccataag gcacccagag ctgtaatcgg 2072641 agtaaaaagc gtcgtgaaaa tggtcagcgc ttttacaatt tcattccccc tatgtgaggt 2072701 aatgacttcc tctgaatgca gcagattgtt aagctcccct tcaaattcgc tgatgtatgt 2072761 aaatcccctg tcaatcttca gttgtgtccg ctgataatcc tttttccctt cattttgagg 2072821 taaaaaggtt tctttcaacg ccatttcaat ttttttagcg cttaatatca aatttttcca 2072881 aatcatcagt tcatggcgca ggagatggac gcggtttaaa atgcttttgc tattgtcgtc 2072941 tttaatttgc catctgagct ttctcagctt gacttcaaat tcatcaacac cgattaaata 2073001 cgcattcatt agttcgccga gaagaattaa aaacccctct atcgcattgt ccgctctttc 2073061 catttgccga acaacttctt tgcctttaat ctctctcaaa attgaaaagt caaagttgat 2073121 tgtaaaaaaa tattgtctgg tgatataaaa gtgaaaaaca gtatggtctt tttcttcacc 2073181 aagcccctga tcataaacaa tcgacccaaa tactgcttca ttttccgttt cagttgtatc 2073241 tactcgcaaa aaattaacgt gatggttatt ttcaaaccac ttttcacact gaggccagtg 2073301 agaaaaatgg attagatctc ttgccttact tctttcttga ggccccattt ggtaccaaaa 2073361 ccaatccttt cccgtatgtg ccttcatgtc aagctcctcc aaacttttgt tctttattct 2073421 ttaattgccc aataaccgcg tcactaaacc agtctgccgc ttcaacacat gttttatgag 2073481 cattttcagg tggtatggaa tgtagaaaga catcggaaaa gggaggtgca tgccttcctt 2073541 ggagaaggca gttgttttgg aatttatcaa tttactagca gtcgctattc tcattttgtt 2073601 aacaggattt ttcgttgccg tagaattttc aatcgtaaaa gtgcggcgat ccaaaattga 2073661 tcagcttgtc gcaaaaggaa agaaaggtgc taaagcggca aagcatgtca tcactcacct 2073721 tgatgaatat ttatcagcct gtcagctggg catcacagtc gcagctttag gactgggatg 2073781 gcttggggaa ccgactgtgc aaactctgct tcgaccgctt tttcataaag caggcttaaa 2073841 tgaatcgctt acccacctgc tttcactcgt catcgcattt ttagtggtta cgtatttaaa 2073901 tgtcgttatt ggggagctgg cgccaaagag tttcgccatt caaaaagcag aaagcattac 2073961 cttgttgttc gctaaaccgc ttatttggtt ttataagatc atgtttccat tcatttggct 2074021 gttgaaccac tctgcccgat tgattacagg agtgtttggg ctgaagccgg catcagagca 2074081 tgagctggct tatacagagg aagaacttcg ggtcctattg gctgaaagct ataaaagcgg 2074141 cgagatcaga aaaagtgaat taaagtacat gaataatatc ttcacctttg ataaacgaat 2074201 ggcaaaggaa attatggtgc cgcgaaatga aatggttagt ttgtcactag atgaagactc 2074261 catttcaaat cttcaggaaa cagtcaagca aacaaaatat acacggtacc cggttgtaag 2074321 agaggataaa gataacgtca ttggcgtgat taatatgaaa gaagtgctgt tttccatgct 2074381 gacgaaagat ttttcaatca agaagcatca aattgaacct ttcgtacagc ccgttatcca 2074441 tgtaattgag acgattccta tttataaact attgctgaaa atgcaaaagg aacgcactca 2074501 tatggcgatc ctcatagatg aatatggcgg gacgtccggt ttggtcactg tcgaggatat 2074561 tatcgaagaa attgtaggag aaatccgtga tgaatttgat gcggatgaag tgcctcatat 2074621 ccgcgaactt ggaaaggatc attacttgtt aaatgcaaaa ttattaatca gcgatgttaa 2074681 cagcctgctt ggaaccgatt tatcagaggc tgaagtagac accttgggcg gctggttttt 2074741 gacacaaaac atagacgctg agcctgaaag tgccatagaa tatgatggct actcttttaa 2074801 ggtaaaagac atcaacagcc atcacatttt atttatagaa gttaaaaaag ctgaatagcc 2074861 cgtgaaaggc tgttcagctg ctatctttca agataaacat ggcaaaggca tcaacactct 2074921 tttattttaa accctttatt ggccagggct ttagcaagac tttgctctgt tttcacattc 2074981 gaaaaatcca gacccagctt cacgacagtt tgggcaattt ccggcctgat tcctgaaata 2075041 atagtctcaa tgccgagcaa tttggtgctg tcaatcactt taaaaatttg ataggctacc 2075101 atggtatcaa cgataggaac gcccgaaata tctaaaaata aatacgagag ctttaacgct 2075161 gagcactgct ccagcacaga ctccaaaatc gtcctcgctc tgtgcgtatc aatttcaccg 2075221 acaagcggaa gaatcccaat tccatcagta atcggcataa tcggcgcact caattcatta 2075281 atcatttctt tttgcgcgtt taattgtatc atggtcacct ggtgatattc ttccgtaaac 2075341 acttcgatga tctcatcaat gttttgattc aagatccggc tccactcata aaattcctga 2075401 atgctgatgt cttgagaaga agcttcgctg aatttatgaa tccattcaaa catgatgtgc 2075461 ctgaaagtgt taaactggcc gacactttgt gtaaccgtca cttcatgaac ggcacggtct 2075521 ctggcgcatt gaagagacca ccggttgagc tcatcctcta cgtcttcttt tctaagggat 2075581 tttgctacga tggtcaccaa taattcatgc tggtctttta acttttgttc tagtttttgc 2075641 tgatctttcg ctgaatacag ccagctgccg tttgacgtac aaacttccag ccattgttgc 2075701 gtaatatctt ttttgtgctc tgttaagtgc tgatcaagag ctatcatctt aatgagttac 2075761 ctcctgtttt tgaaaaatgt acgctatata tgtataacgc gtctgccttt acacatacta 2075821 tgtttagatt caatgggcta tagccaagcg gtaaggcaat ggactttgac tccgtgatcg 2075881 ttggttcgaa tccagctagc ccagtttctg aacaggtgaa aaaccgaaga taagctgatt 2075941 cgtataaatc agcggatctt cggtttttca tcatgcagat tgatgaaccg ttttcttctt 2076001 cgataacttc aacagttctc ccgggttata accaatcacc agctttttgt tgtctactag 2076061 aatcgggcgt cgcaaaagct tcggcttctc gattaaaagt tccagcacct catttaccgt 2076121 catttcttca atgtttaaat ttaaattttt gaaagtctgg cttcttgtcg ccaaaatttc 2076181 atcaattcct tctgtcgtta acgataaaat gtactttaat tcttctcttg tcggggtttc 2076241 tctgaataag tgccgttcgt taaattcaat ttgatgtgct ttaagccaat gttttgtttt 2076301 tcggcatgac gtgcagcttg gatatgagta aaaagttaat tgttgttcca ttcgtttttt 2076361 cctcctcagt taaccatctc tttgtagaat aactacccgg atcatttttc atttaaacca 2076421 tttacagaac ttttttcgga ttatttttta aaaaacattc atacaataga aaacacaatc 2076481 aaagggacaa attccatttg tatattaata atgaaaatgt ttacatttct aggtgtgatc 2076541 tattataata acagtcagag ggactctcgg gaggggataa aaatgaatcg catgttccgg 2076601 gtgttaggat tttggacggg aatttttgca gtcatgtttt atttaggtga tatgaaagat 2076661 gcttcccttt tattttttgg acagacgatc ttatttgtgt ttctatcgta tttgaactta 2076721 accgaacgca tgtatattta tatttttggc gcttatttaa caattttctt cgccggcttt 2076781 acatattact caatttttat tatggtgccc ggcggcggag gccattaaat gcagaaagag 2076841 acaaacctta tcggtttgtc tcttttttta caatgaaaac ccatttaaaa acggattttg 2076901 atcctgctca gtcagtacgt ctgtttcagg tccatggccg cttaacacca gcgtgtgttc 2076961 cggaagcgta agcagttttt catgaatgga cgtcagcagc gtctcttgat tgccgcctat 2077021 taaatccgta cgtcctatac cgccttggaa caagacatct ccggaaatga ccaagtctgc 2077081 atctttcacg tagtaagaca cactgcctgg tgaatgtccc ggcgtaaata atgtttccaa 2077141 atgaaacggc ccgatattca actcaccgtc gccttcaatt agatgatctg caggcttagc 2077201 tgtgacttct atccctcgca gcatgccgga gccgtttaaa gaagcgtccg caagccaatt 2077261 tttttcattt tgatgcaggt aaacagggat atcccatttt tctctcactt catcaagcgc 2077321 cccaatatgg tcaaaatggg catgtgtaag caaaatggct aaaggcgtca gccctttttc 2077381 ttttatgtat tgattgattt tatgtccctc gccgcccgga tcaaaaatca gacattgatc 2077441 atcactgatg agaaaatatg cgttcgcttg aatcggccct actggcattc gtctccattt 2077501 cactattatc acctctttct tttttatgct cttattatga gggtttttga aaaaagattc 2077561 aaacaatcgc aatgaaaacg ctatcgacaa acctataaaa aacaggtaga ataaaactgg 2077621 aaagaattgc aggtttttca atgtaaaggg ggctgtgtta tgttacttgt cgtgattttc 2077681 ggccttgtcg ctcttttcgc tttatgggga gtcttgcgtt ctgttagaaa taaaaatata 2077741 ctcgggtttt tattagccgg tgccacctta tttgtctttg gatggtttac cgtgatgacc 2077801 gtaataaaca gcgggtatcc aaccgcacat taaaacctgt atccgatcgg atacaggttt 2077861 atttttatgg ctgtaaatgt ttattgacac tttctatttt gctctcaagc gtcgtttttt 2077921 tgtcacgcct gtcatcgata cggatattcg ttgccactct gtgcaatcct ttttgaaatg 2077981 gcgcttcgtg aattgcctga ataactgcaa aaaggtcact gagttctccc tcgatcagcg 2078041 tattcatcgg tgtcagctga tatttgattt tcccttctgc ttgatatcct tctaatatct 2078101 tttgcacatc ggctacgtaa gcactgacac tgggtgtttc cgtaccgatt gggataatgg 2078161 ttacatctgc gatagccatc gttattccat ctccttttga tcaatgatga gttgcttcgt 2078221 ttcatgtgat ttcaataaaa taatttgctc aaaatgaaag ccgtataacg catatttccc 2078281 gttcggagat atttgaatcg gctccatttc ccgcagagac acaagatctt ttgtctctcc 2078341 cgatgctaca ttgattgctg cgagcttata tgcatcgccg ctttgtttga atgtataaaa 2078401 caggcctcct gcttcatcat agtcatactc cattggagcc aaacttgtat atttcgcttg 2078461 gagcggccat ttcgctgtaa caggtgatgt tgattgcggc gttttaaact gatacgtccc 2078521 ttttcctccg gaagctgatt tgacagtaaa actcatttga tggaaagaat cgaagaatag 2078581 aacgttatcc tcaagcttct gttccgtctt agaagctgta tcgaacgtat ataaaggccc 2078641 tgttttatcg tctctaccct cttttacata atcaaatgta tttttggatg tccaatgaat 2078701 gaacggaacc tgtactgggc ttaagaaaga ttcgtctttt ttagcattca cctgatatgt 2078761 atggaaatcc cagttttcat tgaattccgt caccatcatt tgataaggat catactgatt 2078821 ccaagcagct tcaagctcat acgtttcgta atctttttcg taaagcgtct ctccttctgc 2078881 attaagcaaa accactgccg tcttttggct atgtgtgatt tgcagcagaa tcatctgctc 2078941 cctcgcattg atttgaacat caacgatttg accatccgtt tgatagagct ttttcgcttt 2079001 gcctgtaaag atgcggtacg caaaaagctc tgttttcgtc ggattagacg cagtatataa 2079061 tattgtgctg ttattcagcc agccttccgc cccatccgct ttttccgcgg aaagcggtat 2079121 gatgtctttt ttctcatctt ttgccgccga tgcctgtttt tgctgctgat gagatggttc 2079181 gcatgccgat aaactaaaca gcaataccgc cagcagaata aaacaaactg atctcatcag 2079241 cattcccctc cgatcatctt tattctctca tatttgcttc ggcagaaaaa agaaaaagtt 2079301 tcagttactc atgaaaaaat aacgccctcc acaagatacc gcttgtggcg ttatatatgt 2079361 gtgaaaactg ctgaaacggc aaaggatttt ggccttttcc aagttccacc gtataccctt 2079421 ccttaaaata atggtgaata aaccaatcac gaaatccagc atagctgtct atatccctta 2079481 ctcccttata aatgttcccg cttaactcct caaactcctt tatgacggca gcagattcct 2079541 caggctcaag gcctttatag ccccaataaa tttcttctcc ttgagtatga agagccagca 2079601 gtctgtcagg cggattctcc gtgatcagcc ggtacatcgc aatagattcc ggctccgtaa 2079661 gcggagagat tcccggaaaa tcgcggtagc tgggtgctgt cggttttcgg tatttttcaa 2079721 tttcccataa tgatggaaat tgtttattta aatcaacccc gtttatattc gccttccatt 2079781 cattaaaatt tggacgatgt tcatttagcc tttcgagttc atctcttctg gctcccatga 2079841 cttctgatcc gtttaaaaca agatcaacgc catccggatt gacaagagga acgagggata 2079901 aggatgtgct gttaaacagc tttatgggag aaaagccaaa gaaaggcgaa ttgcagcata 2079961 atgacataca gtattcctta aaccatttta gcaggacaga cgttgtaatc cactcattcg 2080021 catgaaatga cgcgttcata tggacctttt ttacggcatg ctccccacca gccttcagct 2080081 cccagatagg cctgccgagt acagaacggc caatttcccg gcatgagaca aacggaaaaa 2080141 catcaataat cttctttatt tccttttcaa cagctgaatc atcatagatt ttctcttgct 2080201 caatccagct atctgaaagt ttcagctgcc gaggctgtaa aaagcgcttt atgtcctgaa 2080261 tggtttgaag ctctttgccg ctatgctcct ctatcacata accagggcaa tacaattgat 2080321 gtttttgtgc ggagcgattt gcacttttaa gcaattcctc gtctatcttc agttctttcg 2080381 ccacattggc caaattgttc ttgatctcag gtttcaccgt aataaacgcc atcatcatcc 2080441 cccttttttg ttactatatg acagcgtatt taaaaaaaga aagcctcccg ctcacttcga 2080501 tgcgggagac attgtgatta tgatgcctga tcaagcattt gtttttcttt ccgctttgac 2080561 gaattgtcca gccttttctg gtcataaaat cgcaacaaat ccccataaat gatttcatca 2080621 gaaagtgata gctcctgttt tgctttatca gcaaatgctt cacattgttt tgtctcttct 2080681 aacggttttc ccgtctcttt gtcataacac gcaccgtctg tataaacaac ctgatctgtg 2080741 ataaagctcc cgtcccggag caccgtgaag tccagttttt cgtctgaaag cagatcgttg 2080801 ccgaattgaa tttgatcttt cgtatcaatc cctaaaagat tcatcagcgt cggcctgata 2080861 tcaatctgcc cgcctactgt ttcaatggtt tgcggctttt tatcagtaat acccggaata 2080921 tgaatgacca gcggcacttt ttggagctgt acctcttcaa atggggttat ttcttttcct 2080981 aaaaactgcc ccatcgcttc attatggttt tctgatatac cataatggtc accatataat 2081041 acaataacag agttgtcgta taacccgtct tccttcagct tttcgataaa ccgtttcagc 2081101 gcctcatcct gataacgcac tgtcggaaaa tatttattta gcgtctggct gtttgaatca 2081161 tattcatcaa tcaattgatc ctcttcatca agatcaaacg ggaagtggtt cgtcagtgta 2081221 atcagcctcg agtaaaacgg ctgaggcaga tttttcatca gctctgagga ctgctcaaaa 2081281 aattctttat ccttaagtcc ccagccgact gaattttcgt cagttacatc atacgagtta 2081341 atatcaaaaa acgaatcata tccaaatgag tcgtacatta aatcacgatt ccaaaagctc 2081401 ttattattag cgtggagcac cgctgaatag tatccgctgt ttttcaaaat ttcaggagcg 2081461 gccatatatt gattgcccgc attcgtaaaa aatacggcac ctcgtccaag cggatacagt 2081521 gaattgtcca cgataaattc agaatccgag gttttcccct ggcctgtttg gtggtaaaca 2081581 ttattaaagt tgtagctctg ttttataaag tcattcagaa aaggcgtgat ttcttctcca 2081641 ttcaattttt cattaatcac gaagctttgc gtcgactcta aggatacgag aatgacgttc 2081701 cttccttttg cagcgccgaa taagcgtttg ttggcatcct tcgcattagc ggttacgtag 2081761 ttttcaatct ccgtcaggct gttgctgtct gccaacgctc tctgtgcgga ttgctttgac 2081821 tgaagaacgc catcgtaaat atgaaaatta aacaggctaa tgtttttaac aagcatttct 2081881 ctgtcaaatg agcgtgtcaa tagctgaggt ctttccgcct cagacaagcc caggttgaag 2081941 aaataaacag aagcaacgaa caaaaaataa gccgcccgtt catttttcgt tgagggaatg 2082001 tccgattgaa aagctttttg ccggatgtga agccatatta aaaccgcaat atctacagct 2082061 aataggaggt ctgtcggctc aagaagtgtt ccgatgctgc ttccgagatc acccatattg 2082121 ctcgtttgaa aaagaacagg gattgttaag aaatcattgt aaaaacggta aaaaaccata 2082181 tttgccagca atacaaacgt gacaagacag ctcatcgcga taatgtagcg atttctgttt 2082241 ttgcctttta aaaacaggct gaggccaaaa ataagcaaca aaaaactcaa tgggttgata 2082301 aacagaataa attcctgtgt tagattgtcg attttaatat gaaaactggt tttgtaaaca 2082361 gcatacgttt tcagccacat caataaaatg gcaatcagca taaatgaaat cttcgaaaaa 2082421 aacgtttttc gcatttcaac ctcctatgca gcacgctcaa aaaaatcagt ctattcccaa 2082481 cattctcatt aacacatcaa attaaatctt aacctgagca caacaaaaaa tcaatttcat 2082541 ttacacaatt ttaacaattt tgatgtttca gccattcatt tttagcgatc caagcgcctc 2082601 cgataacgcc ggcatcattt ccaagtgctg cgattgaaat atcagcagct tgggctgccc 2082661 gcggaaacgc gcatttgcgg aatgttttct cgacttttga tctcagcagt tctccggctc 2082721 tcgatacgcc gccgccaaga acgattttgg atggattaag cgagcttgcc aaatttccga 2082781 gcaccaaacc aagatgcttg gctacataat caaccacctc aagggcaatt tcatcatttt 2082841 cacccgccgc ttcaaacaca tctcgcgctg acaattgttc ggttgctttt aaacgtgtcg 2082901 tctttttagc atttgctatt ttttcttttg caattcttac aattccggtt gctgacgcaa 2082961 ttgtttcgat acagcccgtt ttgccgcagt tgcagggcgc tccgccttca gggatgctgc 2083021 aaatatggcc gatttctccg ccggcgccat ttataccatg tacaatttca ccatttgcaa 2083081 tgatgccgcc gccaactcct gtgccaagcg tcacgagaat gacgtctttt gcgccatcac 2083141 ccgctccctt ccacatttcc ccgagcgcag caatattcgc gtcattttct ataacagctg 2083201 ggatgccggt ttctgtctcc agatggtttt tcaaagcata atttttccac cctagattta 2083261 ctgtttcata aaccactcct gccgccatat ctacagggcc tggtgcaccc attccgatgt 2083321 atttgatgat gtgcttcggt ttttgcagct catccagctt gctgtcgatt gtttttgcaa 2083381 ttgtgacagt aatcgtgtcg ccggttttat ctgtcggaac ttcccactta tgctgaattt 2083441 cgccatattg attaataaaa gcgagtttaa tcgtcgttcc tcccaggtca atgcccgcaa 2083501 accatatctc gtccattttt atcaccttag cctttataaa aatctcttcc gttttttgtt 2083561 tgttccaatt cttttcgaag gacagctgcc gctctggccc actgctcctt ttcaatcatg 2083621 tggttcatgt ataattcctt taattcatcc agcataaact caatttcaag ctctctgtct 2083681 ccaaaataaa caatgtggcc aaacgttttt aacagctgct gcacatcata aaatgtattc 2083741 attttcctca ccatttcttg aacttaacta tcataagcgt attcataagg aagcggtcag 2083801 tcaagaagaa aacgctgaca aaaaagccag cttcctttcc atattccacc tctatgattc 2083861 tttattgttt tcaatttgcc gctgcagctc cttgtagcgc tgctccttcg gcttcagttt 2083921 cacagccgtc tggatggcct tttctgcttg tgcaagctca tttttttccg catacaataa 2083981 cgctaaattg taataggaag catggtcttt aggttctttt ttcactgctc gttccaaaag 2084041 ggaaaccgcc tgatcatatt cgccgatttg aatatcagaa acagcaagaa ttttcaaaag 2084101 atcggcagag gcatcttttt gcgctgcttc tccgttcagc aattctgtta cttcttcata 2084161 ctttccttcc tgatacagct cgcttgcctg ctgaatcagc gctgactcct ggtgtgaagg 2084221 cgaatgcaat ccgtaatata aaaatccaac agccaaagca atcagcaaaa ccgctgacaa 2084281 caatcttttt ccaaaggctc cggctttagg caaccccagt gctgctgcag cgaaaaagcc 2084341 gccaatcaag ccgccgatat gtcctgaatt atcaatattc gaaaccgcaa aaccaaagcc 2084401 cagattgatg ataataatga caataatatt ggttcctata gttcttaaaa acatttttcg 2084461 attagacaaa gcaacataca gtaatgcacc taagcatccg aatatggctc ctgatgcccc 2084521 tgccgaagga tacgggctga acacaaaact cgcaatcgaa cccgtaatgc cagcagccag 2084581 ataaatcagc aaaaatctcc ccgatccata catccgctca accgctgtac caaccgacca 2084641 taaagccagc gtattaaaag ctaaatgcgc tatgccgatg tgaagcacga tcggtgtcag 2084701 aagccgccac cattctcctt gtgcaatcag gctgttttct tttgctccaa aagccaccag 2084761 tgtctccgta ttagtgctgc ctccgtttat ttcgagcaag aaaaacatca ggatctgaag 2084821 cgcaataaat aaatatgtaa aagtcggttt tccgttttga aaaaccgccg cttcagtttt 2084881 tctctgttct tcttgtttca gcactagcga aaggaagcgt tctcgcgcca tttgcgcgtt 2084941 ttcaaacgaa gcgtgttcct ctgaacaatc ttctgtacga aatgatggaa aaaccgcttg 2085001 aagatcatct cgaagcatcg ttcctctaac gatcgccggc tcaactgaca cagttccctt 2085061 ctcaaaagtt ttttttgcaa tctcttccca gtcatcaact ggggcttccg ttgaaaaaaa 2085121 cacgttcagc agcttcatcc ttcgtctgcc caattgatgt ctgactcgtt ctactcgttc 2085181 ggcctgctct tcgatgtctc taaccatttc ttgacggaaa tcaagatcgt gcttataaag 2085241 acgaactaga tcatgagagg acttgtccgg cgcttccagc catatttcat ctgactcacc 2085301 ggcttgtatg acgccatacc cgctattcac caggtgcgcc gcaattttcc aatatgtata 2085361 ctccagcaaa aacatgttta ccgctccaat agtttttttt cattataaca gctggcgctc 2085421 cgaaacgcct actgaaagca aaaaatcccg tttttcacgg gattttagaa agcttgctgt 2085481 ataaacttat tgcggataaa tggaattctt aaaaacaaat ggataaaaga ccgcctgatt 2085541 cctggctggc tgagtacagt attcataaga cggtagcgat tttgataaaa catgacggca 2085601 gaaaccgcga aaatggcata tatcaaaagt tttttcatga tatccctcct gccaataggg 2085661 tttgttattc taccttattt attctcgaat aagggacagg aaagttatga aaaacaagaa 2085721 ataatccgat cctctgttat cagcttatgt accgggatgt catgcggcag acggggtacg 2085781 tgcgcaaaca actggcactc caaaagcaaa gagactgtct tcccttcata ttcacttaaa 2085841 tagcgatcat aatagccgcc tccaaagccg accctaaacc cgttaacatc aaaacaaaca 2085901 cccggaacga tcatcaagtc aatttgtgat gggtttactt cttttgtttt ttcaattacc 2085961 ggctcgagca gtccggcgta cacggtttcg agctgatcat cagtctgata tgtgcgaaat 2086021 tgcattttct tcgtgtccgg atggcatttt gggatgcaaa cttgtttccc ttcttcccaa 2086081 gcctgctcaa tgacaggacg cgtcggtatc tctaatcctc tggaaatagt gacggcaatg 2086141 gtgccggcat tttgccactc cggcagagaa aacaagtact tatacatacg ttccgttttt 2086201 tgaagaatat cttcatttga taaagcagac agtgcctcca gcgtcttttt tcttaattgt 2086261 gatttcatct ctcatccccc tcggaataga aaaaaagcca gaaccttttt caaagctctg 2086321 gcttttttct tacacctcaa acagcaaagc tgttattttg tttcacggtg taacgtagat 2086381 tttttatcac gtgggcaata ttttttaaat tcaacgcggt ctggattgtt gcgtttgttc 2086441 tttttagaaa tatagttacg ctcaccacat tcagtgcaag ccaaagtaat attaacgcgc 2086501 attattttcc ctccaaacta aaatcattta cttattcaga cttatatata ataccactat 2086561 aatggacgga atgctaggct gtttttcaat gaattgctga attattgaag atacgctcat 2086621 aaagctgcaa atatgatgac ataatgagtc gggggtggtg gagcttgaac acttgttgtc 2086681 tgccagcttc ttttatccgg cgggcttttt cccggtcttt taaaaaactg tccagcagat 2086741 cagcagcttc ctgtacgagc gtaaaatcag cgatgattgc cgttttgtca tgaaccgcat 2086801 aatcacaaaa accacctgac tgagaaacga cagtcagcac accttgttcc atgctttctt 2086861 gcgcggcaag cccaaacggt tcataagaac tagggaaaac agccatttca cagtgagaca 2086921 gtaacgttct gatatctttc ctatttagaa acggcagaaa catgacgcga tccttcaggt 2086981 tatatgccgc agccaatttc tcatagcagg acagagacgg cccctcccca gccagcacta 2087041 gatagaggtc aggctgacgc tgcttcaaga tggcaaacac ctttaacagc tgcgataatc 2087101 ctttttccgg aacaaacctt ccatatgaaa agaggaatct tctattcatg cttctcggga 2087161 ttttcccctt ctcttcctcc atagatgcag ggcttgggat aacggttatt ttcttatgtg 2087221 ccgccttatc aagagaccgc ttcataaatg tgcttaatac gatcaatgca tcagcggatt 2087281 ctataaggag ccgttcggtc atgagcctgt atgggtgtgg ggcttctcgg cacaccttct 2087341 tcctttcgct ttcaagaccg tggattgtcg cagcaagcgg aaggccaagc cgttgtttca 2087401 aatactgggc ggcaggggca gttgtgtcat catgggcatg aatcagatca aagcgtttat 2087461 tgtgtgataa cacatggcga accattgtaa agttagcatc agctatgtaa tcttcaaact 2087521 tcgcatacga aaacagctgc ccgctcggag taaaaaccgt aatgttgata tgagggttta 2087581 aataggaaat gaggcggttt aaatggacac cgagcccgct tttcggctca tcgggatgtt 2087641 cgggtgaaag catgagaatg ttcaccgttc tttttcccct ctcccataac aggtgtatgc 2087701 agaaaattgc gcctcccacc tggtgtgcgc ttcttcaatc tgaaaactgt ttatatgacg 2087761 aatcccattt tcatcaagat agatgtcgtc tgtaccggca agcttgagag agacattcat 2087821 tgaattcaca attctgtatt cagcccgata tacagcatca ccagccgcct gtctaatcgt 2087881 ccattctcct ttatcatacg ttgtgcgttt tgtcctgaca gcttcaatgt cttttctttt 2087941 gatgacaatg cgcaattctt ttatcatatc ctgcgttttt tcgaaaagga ccgcttcagc 2088001 cagccgcatt gtttcttctg agatttccca gcttacggtc aaggtgtgag cgttttgaat 2088061 gattatgtcg aatgtgtccc taaaaaagga aagcttatgt cgtatattat agggaaatgg 2088121 gtgtttatcc atggactcct aacattctcc tttccaatcg ttcacttcgt gttcctatta 2088181 aaccattaca tgaagaagaa gcgaagaaag atttctcgac aaaatctcgt ttttttcgcg 2088241 aattccttta gaaactattg gttttatggt ataaaaaaga aggataaaaa aagaatagaa 2088301 ggtgatgaaa cgtggaaatt gctattattg cgttgtttat cgtcagtata gcgctaattg 2088361 cattctcata ttctcaaaga gacccgatga aagatgtaga acaggagctc gaaacactgc 2088421 agctttctgc gatgcaggaa atttacaagc tcaaaaagaa aatgacagtg cttgaggaag 2088481 aattactgga aacaaacctt gtcattcgca aatcaaagca gaacgacatc aatcaaaaaa 2088541 tcgctaaaca aatactttct aaatataata acggtatgtc agctgaagcg attgctaaag 2088601 ctgaacatgt atcagtggaa gacgtgaata cgattatcaa agataatgag aaggtgctcg 2088661 tatgacaaaa cggggcattc aggcatttgc tggcggcatc attttagcga cagccgttct 2088721 tgcagctgtt ttttatctga ctgacgaaga ccaggccgct gctgtaaaag ataataaaac 2088781 agtaaccgaa caagacgtga acaattatct tgattctaaa aaattggttt ctgtcaaccg 2088841 tgatgaatat caaaaacttc tcgattcaaa agagaaatcc ttaaacaatg acagcggctc 2088901 agacacgaaa tcagacaaag tcaaaaccta caagctcacc attaaagacg gcatgagcac 2088961 ggcggatgta tctgctattc ttgaaaaaga gggcattatc tcttcggctc aagactttaa 2089021 tgactatgtc attgatgccg gctatcacaa agaaattcgt gccggcgagt ttaaagtaaa 2089081 atcagacatg agtttcaaaa agatcgtaaa aacgttaaca cgataaaaaa acaggctgac 2089141 tcagcctgtt tttttcatcc aaactttcct gaaatgtaat cgagcgttct ttggtccttc 2089201 gggttagaga acattttatt cgtattgtcg cattcaacaa gctcgcccat gtagaaaaag 2089261 gcggtttgat cagaaaccct tgctgcctgc tgcatgttat gcgtgacaat gacaattgta 2089321 tatttatctt tcagctctag aatgagttct tcaatttttc tcgttgagat tggatctagt 2089381 gcagatgtcg gttcatccat cagcaaaata tcaggattgg tcgcaagtgc tctggcgatg 2089441 caaagacgct gctgctggcc ccctgacagc gaaagagcgg acgtatgcaa tcgatccttc 2089501 acctcatccc ataacgccac gtcttttaat gacttttcca caatttcctg aagcttcttc 2089561 ttatttttgg tgccgtggac tctcggtccg taagccacat tatcaaaaat agattgcgga 2089621 aacggattcc ctttttggaa taccatgccg atattttttc gcaaatccac gatgtccact 2089681 ttatccttta aaatgttgct gccattatag ttcagctcac ctgcaagctt tacattcggc 2089741 gtcatttgaa tcattaaatt caatgtcttg ataaaggtcg atttcccgca tccggatggt 2089801 ccgataatcg ccgtaacctc attttcataa atgctcaaat tgatattttt taaagcatga 2089861 tgctgcccat accataagtt cattccattg acttgatata cttcctgttt cattacagct 2089921 tcggtagcaa tactcattgc cgccctccta tccgaatttc ccgttaatat aatcctctgt 2089981 cttttgcttt ttcggactcg tgaaaatctg ttcggtctgt ccgtattcta caagctcgcc 2090041 gtttaaaaag aatgccgtcc ggtcagaaac ccgcagagcc tgctgcatat tgtgcgtgac 2090101 aataataatt gagtattctc ttttcaatcc tgtaattaat tcctctattt ttgcatttga 2090161 aatcggatca agcgctgaag ctggttcatc aagcagaaga acagccggct tcatcgcaag 2090221 cgttctcgcg atgcataaac gctgctgctg gccgccggat aacgagagtg cggatgaatg 2090281 taaacgatcc ttcacctcat cccagagcgc tgcttttgtt aaactttctt ccacaatttc 2090341 atctaaaaca gctttattcc gctctccggc atatttcaat gcatgtgtga tattcgcata 2090401 gatcgatttc ggaaatggat ttggtttttg gaaaaccatt ccgatttctc ttctcaagct 2090461 gacaacgtta atattgccgc ccaatatatt taatccctca taaaggattt caccttccgc 2090521 tcttgcagat ggaattaaat cgttcattcg gttaatattt ctcaaaaaag tagattttcc 2090581 gcatcccgac ggcccaatta aagcagtcac cgcatttttt tcaatatcca tgtttacatg 2090641 atgaacggct tgtttatttc cgtaataaat ggacagatct ttgacctcaa gcacgtggtt 2090701 ctgcttcgga acaataacag ctcgctcagg tttttctttt accatttgtt cagacatgtt 2090761 tttcgcctct ttccgttcta atttgccgta agctttttgt agatcatcgt gccaagccat 2090821 ctcgccgcga gattaaacac aagaacagaa atcaccagca cggcagaacc accgttggca 2090881 atcgcttcag catccggaat cattccttgt gtattgacgt tccaaatgtg gaccgcaagt 2090941 gtttcagcgg gcctgaaaat attaagcggt gatgtttccg aaaacgggtt ccactccgta 2091001 aaattaagac gcggtgttgt caggcctgcc gtaaataata atgcggccgc ttccccgaac 2091061 acccttcctg acgctaaaat tgctcctgtg atgatagaag gaatcgcact tggaattaaa 2091121 actgttttta cggtatgcca gcgtgataca cctaaagcga gagaggcttc cttcagatct 2091181 ttagggactg aacggatcgc gtcttctgtc acacgcacca tgacaggaag gttaaaaaca 2091241 gttaacgcaa gcgctccgcc tatgatcgta taaccccagc ctgttaagtt gacaaacatc 2091301 aataatccaa acatcccaat gacaatagac ggaagagatg aaagcacctc tatacatgtt 2091361 ctaatgaagt cagttacttt gttattaggc gcgtattcag ccatgaagac tccgccgccc 2091421 acaccgagcg ggattgtaat cagcattgta ataaacaaaa tataaaagga gttaaacagc 2091481 tgatctcgta tgcctcctcc agctgcaatg gcgctcgact ttgttgtaat aaattgaaaa 2091541 ctgagctgag aaacaccgtt tataataata taggaaaaca aacctactaa aatggcagcg 2091601 ataatggctg cacacaaacc aaacattccg gtcgccagtt tatctgttat tttgcggttc 2091661 attacacttt cctcctagat gacaagtagc gaataagcag gatgaacaag aatgacatca 2091721 ccagaagcac aagccccatt gaccacagcg tattgttttc aacacttccg tatgtggtgt 2091781 ggcccatatt cagcgtgatg atcgttgtca gcgttcccgc agtgtcaaac gggctttccg 2091841 gcaatactct tgtatttcca atgaccatct gaacagccaa agcttcaccg aacgcccgag 2091901 ccatgcctaa cacaacagct gtcatcaatg ttggaaaagc tgcaggcaca agtacttttc 2091961 tgatcgtctg ccatcttgtg gcaccaagcg cgtaagaacc ctctcgtaaa ctcttcggaa 2092021 gagaagccat tgcatcagca gaaatcgatg tgatcgtcgg cagaatcatg acggaaagga 2092081 caatcgttcc cgccaataaa ctgtgccctg ttccgctcga tttgaactgg gcgataaacg 2092141 gcaccaatac tgtaagacct atgaatccat aaacaacaga tggaataccg actaaaagct 2092201 caatcaccgg ctgcagcact ttctttcccc aattcggggc aatctctgtc ataaaaatcg 2092261 cacctgcaat gccaagcggc gcagcgatta gagcagaaag aatcgttact gcaaatgagc 2092321 caaaaataaa tggcagcact ccgtatttcg gatcactatc tgtaggattc caatttaagc 2092381 tcgttaagaa ttcaattggg cttacaccat ttacaagaaa agattgcagc cccttaacgc 2092441 cgaggaaaat ggtaatcgca acagatgccg caatcataat cagtgcacaa gctgtgacta 2092501 tcattcttcc ccgaacttca tccaattgcc gattttgcct agagctgatt aagcgctcgc 2092561 tcacagacat attttctcta ttgtttatca ttgttttaca ctcctatgaa tgtgttaaga 2092621 ggagaaacgg ttgtccccgc actcctcttt ttattaagat cagctttgct tcccgttggc 2092681 atcacgtgtc actttcatat cagtaaccgg aatgtagcct tggtcagtaa caatgctttt 2092741 ttgaatgtct tcactcttta gataatcaag aaattcttta gctaaacctg tcgcttcacc 2092801 ttttgtataa gaatgttgat aagcccagat cggatactcg ccagttgcta catttttcgc 2092861 ttcaggttta acaccgtcaa tagatagagc agttactttg tcatctgtta aatatgagaa 2092921 tgcaagatat ccaatcgctc ccggagtatc agcaatgatc tttttcaccg tgttggagga 2092981 atcttcagta atgccttctg caggctccgc tccgtcaagc gcatatttca caaatgtagc 2093041 acgtgtgccg gaagaatcag ggcggtttac aagtgtaatc ttttggtctt tgccgccgag 2093101 ctctttccag tttttgattt tgccagtgaa gatttttttc aattcatctt ttgaaatatc 2093161 ctttacacca gcatcagggt ttacagctgc tgccatacca actacagcga cttgatgatc 2093221 gacaagcgct tttgcatcga tgccttcttt ttcttcagca aaaacgtctg aattcccgat 2093281 ctgaacagct ccttcagaga cttgagaaag ccctgttcca gaaccgccag cttgtacctg 2093341 tatatcagca tcagggtttt cttccataaa tttttccgcg gctgcaagta ctagtggctg 2093401 cattgccgat gaaccagaaa tggttaaaga acctgatgcc ttttcttctc cttttgcaga 2093461 atcgctattc gattttttac tttctcctgc atttccgcat gcagctgcaa tcatcataaa 2093521 agcagccatc agaagcataa gcaccaattt gttttttttc atttcctgaa ttccccctgc 2093581 gtataatgtg taatttgtcc tacacgtata gagtaaaggt tctatgtaaa aagggtttga 2093641 accgaatgtt aaggttttgt aaatcagtgc gtttttttgt ataaaaaaaa cgcccacatc 2093701 atgtgagcgt ttttttttag ttatcagaag acgttgtgtt ttctgcattt tcttcaattt 2093761 tgtctttatt cttttgctga gtaccttctt tgtcctgctt cgatttcagc tcaaaatatt 2093821 tatccattac ttccctgccg atttcgtttg taattgagta tctttgattg taatcaatgt 2093881 aagtccaagg aactacgaca gaaatagcaa tctcaggatt gtcagctggt gcataagcca 2093941 caagcgtcgt attataagtg tctgttcctg tttttgattt atccggtccg tcgtaaaatg 2094001 attgggctgt tcctgttttt gcagctggtt tatacgatgc tgaagccagt tgacctgcag 2094061 ctgtcccttt agtggcaacc cgtctaaaac cggcttggac ctcttcaata tagctactct 2094121 tcatatcgac tttattcaat acttcaggct gaacagaatc aacgactgcg ccgatccctt 2094181 ttttcgcatt tgaatctctg acttccttta caagctgagg cttcatgcgg tagccaccat 2094241 ttgctatggt ggagacatat tgagccaatt ccagcggtgt ataagtatca tactgtccaa 2094301 tggcgaaatc aagcaagaaa ccagataatc tgcttgtacc tttatatccc gtcatttcat 2094361 ttggtagatc aattcctgtt tttactccta atccaaattg actgaaataa tttctgaagg 2094421 tatcaaatgc agaagtatcc aaaggcaatg cttggtgagg tttatattca cctttaccaa 2094481 ctgcaattgc tgttttaaac ataaaaacgt ttgatgactt ctctaatgca gtttgaatac 2094541 caaccggccc taagttttgc caagattttt tccctctttt atcctggccg atatacaatg 2094601 gttcatcctt aaatacagta ttcaaattaa tcgctccagt ttgaagaccg gtcaaaacgg 2094661 ttgcaccttt tacagctgat cccatagcgt aggatgaagt catggctcct aatgcataat 2094721 catcaaactt ataggctcca ttttctcgtt taatctgctt ccctgccatt gtcagcactt 2094781 cgccgtttct agggtccatc atgacaacga atgcacgatc caacaattcg gtactaggtc 2094841 ttgctttagc agctttaagt tttttctcaa taattttttc cactgatttt tgcaaatcaa 2094901 tatcaattgt tagtacaaga tctttcccgg ctttgccttc agataccgtt tttgttcccg 2094961 tgacattgcc ttttgaatct gtgatatttt cgacttttgc tttttggccc tgcagaaggc 2095021 tttcatattg gtattccaga tagctttttc cgaccctgtc atttcggctg tagccaagcg 2095081 acagataatg gtcgagcaag ttggacggca atccttcatt agagctggaa acacttccga 2095141 gcactgagcg aagaaggttt ttataaggat attcacgttc ccaatcggac gtgacatcaa 2095201 cacctggcag ttcgtctaaa tgttcactta ccactgccat ttccttcgct gatacatctt 2095261 cgtttttgat atattgaggg gtcaatgcat agcccgaatc catctgtctt ttgatagcaa 2095321 ggatctgcat atctttatcc gtcaattcat tcagctgctt atcagtaatc cgttttagct 2095381 gaagctggta taaatcgtca tcggatattt ttttgtcttc aacctgctgt ctttctttag 2095441 agctaatgag ctttttcgct tctttcggtc tagtcaaaat ccaataatct tttttatccc 2095501 gttctgttac tttttttgta tcgactttga tcatgtcaga cagctttttt gcgatcttta 2095561 agcgctgttc ttgcgtggtc gatttagatc tcgtgtatgt gattgcattt aaagccttat 2095621 ttgtcacaat ggcattaaag tttcgatcat aaattttccc gcgtggtacc gctgagctga 2095681 cttcactttg ttcctgctta ttcgcttggt ttttgtaatc atcaccttgc acgatctgct 2095741 tgatgcccag ttccacaata atccaggtaa atataacaaa ggcagctaaa aataaaatat 2095801 tcagccggat cggaagcgac ttctttttct ctttatgatt ttgctttttt ggtttatttc 2095861 tcctcataac atcacctttt ctatttacag aaagaaaaga cactcaagta agagtgccag 2095921 ttttcatttt aaaggttttt tcgacttttt tctacagata accccttttt ggcaaaaaaa 2095981 ttatctctcg ccttttaaaa gggtcggttc tgttacccgt ttttggccgt cttcttccat 2096041 ggtttcattt tccccttctt tctccttaaa acgaatatcc ttgacaaagt aataaatcaa 2096101 aggatgtcct atacccaata tcgcaagtga caaaggaatt cccacatcct ctttcagaag 2096161 ggccacaatc aggagaaagc acaaaatgga aacaattctg ccggcgttca agaacatttc 2096221 tctaagcacg atatattcaa ttcttgcttt tctggcatgc ctcgcgcgcc ctatcacatc 2096281 atatgtaagt gatacatatg gcacaagcaa cagaggatag ccgatggcaa taaaaacgcc 2096341 gtacgttaat aatgtcgaaa agctcatatg gaacagaatc aaaaacagcg cgccatacaa 2096401 aataagtccg cccagcaaaa tcgatttttt tctcgccttt ttcttaatca gcctggatgc 2096461 aaagtagtag gcaaagaagg aaacagctga attgacaaga ccgaatgtac cgagagcaag 2096521 ctcgctgttt gtctcaataa atacaaacac actgattaaa aagacaaaaa tcccttctct 2096581 caaaccctga aaaaaatgcg cattcgtgat tctccgccaa ttcatattgc tatggcgctc 2096641 tccaaatact ttgctcagca taaaacggcc ctttgattct ctccgtttta agaaaaagct 2096701 catcacgaca gccagggcaa ataaactgag ggagagactg aaaatcactg tataacccgt 2096761 attattttca agccttgaga tcacgaatcc ggctacaatc gggccgatca ttcctgcaga 2096821 ggaagacaga atgcccataa acccgttgaa aaagtctcgt gtatccggct ctgttatttc 2096881 aaaggtcagc acgttaaacg ctagccaata aaagccatag ccaactccga gcaccgcgcc 2096941 gattagcacg aggcggctgg ccgccgtttc tccggctaaa agcacactta aataaaaggc 2097001 agctaaaaaa atgacgccga accttaaaat gaataccctg tctatttttt tggctaaccg 2097061 tccagccaaa taaaaggtta tcggctgcat tgtcacaatg gataaattat atatcgccaa 2097121 atcaataaat ttccctgact gcttccaaag atacacatta acaaatgtat tggacagtgc 2097181 aattcccagc gagtaaagcc cgccaatggt cagcagaaag agtaagcctt tgtttacgtc 2097241 tacatcgcct atcacttttt ttagtttgct cattactgac tcccctttac tatcccttag 2097301 tctgtctcac tcaaaccgag atatgtaaaa agaagacata aaaaaacaag gtcccataat 2097361 gaggaccttg tttgtgccat tattttgctt cgctgtatag acgagccact tcgtcccagt 2097421 ttacaacatt ccagaaagct gaaatgtaat caggacggcg gttttgatag ttaaggtagt 2097481 aagcatgctc ccaaacgtca agacctaaga taggcgtttt gccttctgaa agcggagaat 2097541 cttggtttgg cgtgcttgtg atttcaagtt taccgttgtt cacaacaagc catgcccagc 2097601 cagaaccgaa gcgtccagct gctgctgctg cgaattgctc tttgaatttg tcaaagcttc 2097661 caaatacact gttaatctct tcagcaagcg cgccagtcgg ttcgcctccg ccgtttggag 2097721 ataaaagtgt ccagaataat ttgtggttcg cgtgtccgcc gccgttgttg cggactgcag 2097781 tgcggatgtt ttcaggaaca gaatcaagat ctgcaacaag ctcttcaact gatttgttgg 2097841 caagagcagt gtttccttca accgctttgt ttaaatttgt cacgtatgtg ttgtggtgtt 2097901 tcgtatggtg aatagtcata gtttccttgt cgatatgcgg ttctaaagca tcgtacgcat 2097961 aaggtaattc tggaagttcg taagccatga taattcctcc ttagtatata tgtactgaaa 2098021 tgccgcttca cagcgagcct ttcttcattc aatgtaacaa aagaatgctt tgtaatcaat 2098081 gaaaaagctc acgatttggc tcatttcagc ggacatattt cactttaacc gataatctgc 2098141 cccattaaac ctgccgccag catttcttat aggaccgtcc ataaaaagta accgatcatc 2098201 aaaagctgta tgatgccctt tgcaataacc cctgttaaaa aaccaatgag tgagccgagg 2098261 ccaattttaa acgctgactt taagtccttc tgatggacga taagttctgc gcaaacagcc 2098321 ccgataaacg gccccaatat gatccctgca accggaatga caaaaggccc gattaataaa 2098381 ccgatcgtgc ttccccatat ggcagctttg cttcctccga acctttttac tccaagcaga 2098441 ttcgacacgt aatctgctgc gaataatact gcggcaaaaa ctgcctcaac aagccagaac 2098501 atataagaat acggactgaa tgaaaataaa aatccgtaca atacaaatcc ggcaacaata 2098561 aatactacgc taggaataac aggatacacc agcccgataa aggcaatgat aaaaaccgct 2098621 gcaatcaaca gccaatacaa catatccata gcttccatcc tcccatttta ctctgtcttc 2098681 ttcatgtctt ccttgtattc acacgcatgc aacgatacaa taagcaacat atattagttt 2098741 agctaggaag tgaagatagt gaatgtgttt cagcttttca ttaaaagtac atactctccc 2098801 cgtgatattg caaaaacaag atttcaagga atcggaaaag cgattcttta tgtatttttg 2098861 ctctctgtcc tgtttgcaat ccctaccgct tattatgtaa gtacagggac cgtaaaatca 2098921 atgaacggct ttaaaactgt tttaaacaaa gatttccctg atttcacaat ttcaaacggc 2098981 aaacttcaaa cggatgagaa aaaagccacg gaatctcagg caaatggttt cgttatcgtg 2099041 ttcgatccga cagactccta tggcactgaa caaattgaag caaagcaaaa cgcaatcggc 2099101 atccttcaga acaaatttgt tttggccatt gacggacaag cccaagaaat gtcttactca 2099161 atgatgccgt cagagttaca gaaaaaagat gtcattgcag gtttaaacca aaataaagcg 2099221 atgattgtaa ctgttctctc agctcttatt tttctcgtaa cagcagcggg aaaatttatt 2099281 gaagtatcgt ttttagcgct tatcgggtta atcattaaga attcgcagaa aaaacattta 2099341 tcctatcatc agctctggaa gctttctgct tattccatca cactttcaac tgtattcttt 2099401 acaatcatgc gggcactaga agcaaccgta ccaagtgaat ttttgctgaa ctggtttgtc 2099461 aattttgtca tcctgtttct cgttttaaaa gagattccgt ccaaaaaagt aattaataaa 2099521 agttaaatta tatttatttt tatcctttaa gtagagagtg tgaaagcatt tgcattaact 2099581 ttttacttaa gggatattta ataaaatgta tagagcttaa acagatacat ttataaaaaa 2099641 agctctacaa ttactcaaga acaagctctg gacaataata tcagaagtag taagatgtaa 2099701 catgaaagaa gttcttaaca gcatttgaca tatgttttta acaaaataag aataatgtta 2099761 aattttaact aatagactag ttaaaatcat atggcaaaat attttgcatc ctttcacaac 2099821 atatttacat aagatagttg ctatttaaaa agccaggtac caatagggca cctagctttc 2099881 agaattaaat catcaacaag ttagaattat cttctttcct tctattctca ttattgaact 2099941 gttatctttt ttgtgggttt atgtatacaa atgcagctcc cttagctttc cccttatata 2100001 ctgataaacc tactgcccaa ggtgttcctg tcggttttgg taatttactg aagtaaaact 2100061 ttttggttgg agttctactt gaaaagtacc ctgaatattg cgggccaatg tccccaccct 2100121 caactataga tacaccaaag ctcttataat ttagtttacc gcattttcca tttgtttcgg 2100181 cgtaagcatc aatagatgtt gcactcttag tatatgtata agcatctgta ataactctta 2100241 ttttacaacc agaaatacca cttaccggtt gccaaccact gcttgcagcc tctgcttttt 2100301 ctttaggtgc aactaccaaa gttaacatta gtagcaaaat taaaaacaca gaaaattttc 2100361 cttgcttcat tttgtagatc ctcctttaaa ctattacata attatcctaa cagatccatt 2100421 gttcattgta aataatggaa tacgagtttt atattataaa agcctctttt tgatctaatt 2100481 ttgcactatt ttctattttc tatctgaagt taatgtttag tcgaagaaat cctgtcaaaa 2100541 aagcgcctgt ataaaaaccg agcattcgca gtctcttttc ttttgtcatg aatcgaaatg 2100601 gacaagcata ctatggtata aaatttcgta tgcgggagga aaagcgatga agcgtctcac 2100661 cttagtatgc agcattgttt ttatactttt tattcttttt tatgacctta aaattggaac 2100721 catacccatt caggacctcc ctgtctatga agcatcagca aaaacggctg tacaagaacc 2100781 ggcttataaa acggtgaagg taaagccggg tgatacggtt atgtcgatag tcggatcagc 2100841 aggttctccg gatgacattg taaaggattt tgaagcactg aatccaaatg tgaaagctaa 2100901 cgccattcaa gccggaacag cgtataaatt cccggtctac ccttaattta acgttaattt 2100961 cttgtcagtt cggcgaagac actgttacaa tgtaatttgt aaaataaatt cacataaacc 2101021 atactagaat tgttatatct agaagcggca actacaatta aggagcgatt gcaagtgagt 2101081 gaaatcacac atcgtacaaa aacgcgtccc gtcaaagtgg gacctttaac aataggcggc 2101141 aacaatgaag ttgtcatcca aagcatgaca acaacaaaaa cacatgatgt agaagcaacg 2101201 gttgcggaaa ttaaccgttt ggctgaagcc ggatgccaaa tcgttcgggt agcatgtccg 2101261 gatgaacggg cggcaaacgc cattgcggat attaaaaagc gcatttccat tcctctcgtt 2101321 gttgacatac atttcgatta taaacttgcg ttgaaagcca ttgaaggcgg cgcagataaa 2101381 atccgaatca accccggcaa tatcggccgg cgcgaaaaag ttgaagcggt tgttaaagcg 2101441 gccaaagaca aaggcattcc gatcagaatc ggagtaaacg ccggttcatt ggaaaaacgg 2101501 attttagaaa aatacggtta tccgactgcc gatggaatgg tagaaagcgc acttcatcac 2101561 attaaaattc ttgaggatct tgattttcac gatattattg tcagcatgaa ggcctctgac 2101621 gtgaaccttg caatcgaggc ttatgaaaaa gcagcgaaag cgtttgacta cccgcttcac 2101681 ctcgggatca ccgagtcagg aacactgttt gccggcacag taaagagcgc agcaggactc 2101741 ggcgccattt taagcaaagg catcgggaac accatgcgca tttcactaag cgcagaccct 2101801 gtagaagagg taaaagtagc aagggagctt ctgaaatctt tcggcttagc ctccaatgct 2101861 gccacgctca tctcatgccc gacttgcggc cgtattgaga ttgatctaat cagcattgcc 2101921 aatgaagtgg aagagtatat ttctaagata aaagcgccga ttaaagttgc tgttctcggc 2101981 tgcgctgtaa acggacctgg tgaagcgaga gaagctgata tcggaatcgc cggcgcacgc 2102041 ggtgaagggc tgctgttccg gaaagggaaa attgtccgta aggttccaga ggaaacgatg 2102101 gtagaagaac tcaaaaaaga aattgacatt cttgctgagg aacactacgc aaaacttgaa 2102161 gctgaaaaag caaaattaaa agaagaaaca caaaaagctt gacgggaacc cgtcaagctt 2102221 ttttgtgtta gaaaaatgga ataataaata ttccaagcac taatgaaacg acaccgatac 2102281 ccattgccca ggctccaagg ccttgagcac ctcttcttct tgcgatatag ccgacaataa 2102341 taccagcagc tcccaataaa acaggcagta caaacaatga aatgatggac aaggctaaag 2102401 cgatgtaccc tattccccgt ccttcattga cattgccgcc gctgcgatca ttgtcttggt 2102461 cattgctgcg gtcagcagca cgataaggct ctgcgatttc agcagctgtt tcctcaaaaa 2102521 aaccgtcatt gtcgcgggta atatttgtcc cttcagatcc atgatcaaca tagtaactgt 2102581 tgttatcacg cttttcgtaa tcgtttgcca ccttcaattc ccccttctgt tttattaaag 2102641 gagcttttat agtttgatcc attttgcctg attcatgttt gctaaacttt tctgttaatg 2102701 tcaattgttt atgttacact tgaagggatg aaactgaagg agtgtgggca tgttacgctt 2102761 aggaatagat attgacggca caatcacggc tcaggataca ttcgtccctt atttgaaccg 2102821 ttcgtttaat ctttccattt cattaaacga tatgacggat tatgatttaa caaagctgtt 2102881 aaacattacc caggaagaat tttgggattg gatgaatcaa aatgaagcga tcatatataa 2102941 ggaagcattg cttgcacagc atgcgaaaca gtctctcgat cttctcaaag aggagcacaa 2103001 gcttatttat attacagcga gacggactca tttaactgat attacttatg aatggtttga 2103061 cagacaaaac attcattatg accacatcga acttgttggg ggtcatcaca aagttgaagc 2103121 ggtcaagaat cataacatcg acctgttttt tgaggatcat cacgggaacg ccatgatgat 2103181 tgcgaaagaa gccgggatac cggtgatttt gttcaattcc ccttataatc agcttccgat 2103241 tgattcaaac atcatcagag taaacaactg gctagaagcc gttcaatgga tgaacaacaa 2103301 caagcatcac ttaatacgcg tcaataactg aaaaaggagc ccaaaccggg cccctttttc 2103361 atatatacgc attttacgca gtagtgtttt cttggttttc cgctgtacaa tcagggcatg 2103421 tgccataaat ctcaaattta tgcccgctga cctgatagcc atccaaatca tcacaaagct 2103481 tgtccatcgg acatgattca atttcctttg ttttgccgca ggcaagacaa ataaaatgat 2103541 ggtggtgatg ggtgaatgaa cacttaaatc ggaagagctt ttcaccggac agctcagttg 2103601 tttccaaaat cccaagttct tcatataaag aaagatttct gtagattgta tcaaagctta 2103661 agcctggata atcatcattc agtgcagaca gtacgttttt agcggtaaga tatctgtctg 2103721 aatcagcaaa aagctgcagc atatcctccc gtttgtttgt atatttatat ccgttttctt 2103781 ttaataggtt cagcgcttct tggacgttca tgaagggtcc cccttttcgc tttgcttaag 2103841 aacgtatcac atgtatgaaa aagaaaatgg cagctgtctg tccagcaagc cattttcttt 2103901 actgcagata aaattatacc cataaaatga ataaaagtaa atgaaagcct agtggattgc 2103961 gtttttgaat tttccgcctc tcgtttcatg agtattcata attgttatga atgcattttg 2104021 atcaacttca aacacgatcg atttgagctt tgtcacttcc agccttgtga caaccgcgta 2104081 aattacgtct ttttcttcgt ccgtataccc gcctttcccc ttcagcttcg ttgtgccccg 2104141 accgagacgg tgcaaaatcg cgtcggaaat ctcatcatac tgctcagaca caataatgac 2104201 agcttttgtt tcatcaagcc cttggatcac ggcatcaatc gttttcatcg caatataata 2104261 agtcatgaat gagtacatcg cttgctcagg accgaacaca aaaactgccc aaatgaaaat 2104321 gaacacattg atgaacataa cgaactcacc tacagaaaac gggagttttt tggtcagcaa 2104381 aataccgaga atttctgtac catccattga acctccattt cgaataacaa gcccgacgcc 2104441 aaagccgagt aaaagacctc cgaacacagt agccaaaata ggctgggttg taatggcttc 2104501 tacatggtga agtgaggatt caataacggc aagcccgaca atccctataa acgtagagac 2104561 tagaaaggtc ttaccgatat atttatatcc gaagatcata aaaggaatat ttaatatgac 2104621 aacgaaaaaa gcgaaattca gaaaggggtt tgacataaag aggtggtcta aaataagaga 2104681 tacaccgata atcccgccat caataaaatc attggggatt aaaaataatt caatacttac 2104741 agccgcagat gcagctccta ccagaatcat aaagaccctg aaaataaaat gggtaaatgt 2104801 ttctttctta tgttgttttg ttggggtcat aaaatctcct ttcctgcaat aactatttta 2104861 aatacattat aaatctattt taccattaaa cactgacaca ttttactgat ttgcccatac 2104921 attaagtctg gaggtggaat gaccgatgat tttatttcaa agaattattt tgcagcggct 2104981 taatcaggct actgctgatg atttgctgaa gtactcaaaa caatacggaa tcagcttaac 2105041 aagatcgcag gccgttgaag tagcgaacct gttatacggg aaaaatgtaa acatctttaa 2105101 tgagagtgaa cgaatgcggc tgctgaaaca agtagagacg attacatcga aagaaacagc 2105161 tcaaacagtt aatgaactat tcaaacaatt tacaagctaa aaaatggggg tgttatcccc 2105221 cattttttat tgctgtaaaa tcttttcaag caatgtatca tcaaattgtt tttctttcag 2105281 catttcaatc tcaaaacggt atggcggttt tttgttcttt ttatcttcac cgacgtatgg 2105341 tgtttcaaga atttttggaa tgtcttttaa ctgctcatgg tgaacaacat attgcagtgc 2105401 gtcaaaacct atttcaccaa agccaatatt ttcatggcgg tcttttctcg cacctttgac 2105461 atttttgctg tcattgatat gaagcacttt aatacggtca atgccaatga ttttatcgaa 2105521 ctcatttagc actccgtcaa agtcttcgac aatgttatac ccggcatcat gtgtatggca 2105581 cgtgtcaaag cacactgaca gctgctcatt gtgtgtaacg ccttcgataa tctgcgcaag 2105641 ctcctcaaag cttctgccgc attctgatcc ttttccagcc attgtttcta atgcaatctg 2105701 gacattttga ttcggatcaa tcacttcatt taagccttca ataatttttt tgatgccggc 2105761 ttcagctcct gcccctacgt gagcgccagg atgaaggaca atttgcttcg ctccgatggc 2105821 cgctgtccgt tcaatttctg aacgaagaaa atcaacaccc agctcaaaag tggacggatt 2105881 tgtcgtgttg ccaatattaa taatataagg cgcgtgtacg ataatctcgt caatgccgtt 2105941 ttcttgcata tgtgcccggc ctgcttctat atttaagtct tcaattttct ttcggcgcgt 2106001 attttgcggt gcgcctgtat agatcataaa cgtattcgcc ccataagaga ctgcttcctg 2106061 gcttgcagcc agaagcatat gttttccgct catagagacg tgtgagccta ttctcagcaa 2106121 caggttcccc tactttcttt tcttagattg gtttcttctc tgttttttct tgattttctc 2106181 catctcatag ctcattttct ttttataccc aggcttaacc ttcttcggct ttttcacgag 2106241 acgatgagca atttcatccg cttcattcgg cgttttttta cgttttttgc ggcgctgacg 2106301 gtcatcgcct tttttccatt cgcccttttc aagctctaag tactcaaatt cgatgcccat 2106361 tttttcaagt cttactaatg catcctcatc agtaagctca taaatggtca tcgcttgtcc 2106421 tgatgagccg gcacgagccg ttctgcccac acggtgaaca tagaaatcga gatcatccgg 2106481 cagctcatag ttgataacat ggctgacacc tttaatatca atacctcttg cggcaaggtc 2106541 agttgcaatg atatatgtga attccaaatc attgatctgc ttcatgactt ttttccgctc 2106601 acgtggtgtt aatccgccgt gcagcaagcc gattttcatg cctttgccag tcagatactg 2106661 ggcaatatgg tcagccgtat ttttcgtgtt ggcaaacaca atccccaggt atggattcag 2106721 atgcgacatg atgtcaaaaa ggagcttgtc cttgtcacga tgtttcgaag gaatgaggat 2106781 atgctcgatt ttcgcagcag tcacctgttt tggctccaca tgggcgtatt tcggattttc 2106841 catgtatttc ttcaagaatg gtttcagctt ttccggtatg gtcgctgaga acacaagcat 2106901 ttgcagatcc tcaggcatgc gggaaccgat gtaatctaca tctgcaagga atcccatgtc 2106961 cagcattaaa tccgcttcat caataacaag agattccgct ttatgaacac ttaacgcctg 2107021 ttctttgatt aagtcagcaa tccgtccagg tgtaccgaca acaagatgcg gctgtatttt 2107081 caatttatca attgattttt gtttatcagt gcctccgata aaacatttcg agcgaatctg 2107141 acttccttct tcaccctgcg tgattttaag cgcttcctga taaatctggt tggcaagctc 2107201 tcttgtcgga gccgtaatga ctacctgaac gacatcctta gcaggatcga ttttgtttaa 2107261 taaaggcagt aaataagcgt gagtctttcc agtacccgtc tgagactggc cgatgacgct 2107321 ttcttttttt aacactgcag gaatcagcct tttctggata tcagtcggtt cgtaaaaacc 2107381 aaggcgatgt actgcatcta taataaatgg tttcaattca taaagttcaa atttcgtttc 2107441 tttcattttt cccagctcct taaagcggca cattatgtgt ccatcatcac attatacccg 2107501 attttgctta aaaacaccac gtttgcaagg cgtttgtttt attcagttat gtaaagcaaa 2107561 taccgcagcc catgcatatt ctaatagcag agagagctga aaggaggtac aagtatgttt 2107621 tcaccgcagc agccaatgag aaattaccca cagcccggac cgccccgccc catgccaaat 2107681 cagcgaatga tgggcagaag accgcctaat atgcgaggac cttcatttgg agcacagcag 2107741 caaggttttc agcaagccgg acaatttctt cctcaggcaa atgccggagc gagaaatggt 2107801 gcaggtgcag gcggaggctt aaaaggaatg ctgtcaaggt tcctccccgg cggaggaggc 2107861 gctggcagcg ccggggttcc cggaattcca ggagcaggtg cagcagcgag cggaggtgct 2107921 ggcctgcaag gcattcaaaa tattgccaat cctgcatcat tatccagtat gcttggaaat 2107981 gtgcaaaaag tactcggcat ggcgcagcaa gtcaccccta tgatccagca gtacggccca 2108041 ttagtccgca atctgccagc aatgatgaag ctgtacagcc aattaagtaa aagtgatgat 2108101 actgagacag aggccaatga ggaaagtgaa aaacaatccg tttcagaaga atcatcagaa 2108161 aaagaaaaag agactgaaac aaaaacctca gatgggaaca aaaaatcaaa accaaaaagt 2108221 tcttctctcc caaagaaatc taaaacaact gacaataaag aacaagaatt aaaaacatct 2108281 gccccgaaga aaaaggaagc tgcctctcct gctccgaaaa gaacatcagg cagttcaaaa 2108341 ccgagattat atatttaaca ttctttgata tcttaagtga gattggctat aatgagatca 2108401 gaagaatgca agaatagagc cgtttgatta cggcttttta tattgccttt actcacttca 2108461 gtattggagg acaaccgaaa atggacgtaa ttaaaatttc accgcgcggc tattgctatg 2108521 gtgttgttga tgctatggtc attgccaaaa atgcgtcgct agataaaagc ttgccaagac 2108581 ccatctatat actcgggatg attgttcata ataaacacgt cactgatgcg tttgaagagg 2108641 aagggatttt tacattggac ggctctaacc gtctggacat cttaaagcag gttgacaaag 2108701 gaactgtcat tttcactgcg cacggtgttt ctcccgaagt cagaagaatc gcagaagaaa 2108761 aagggttagt cgcaattgat gctacatgtc cggatgtgac aaaaactcat aatctaatct 2108821 tagagatgaa agaaaaagga tatcacgtga tctatatcgg caaaaaaggg catccagagc 2108881 ctgagggagc cgttggcgta gcgccggaga tcgttcactt agttgaaaca gaagaagatg 2108941 taaagaacct tgatatccaa tctgagaagt taatcgtgac gaatcaaaca acaatgtctc 2109001 aatgggatgt tcacgacatt atggagcttg tcaaagaaaa atatcctcat gtcgaatatc 2109061 accaagagat ttgcctcgct actcaagtgc ggcaggaagc tgtatcagag caggcaaaaa 2109121 aagcggactt aacaatcgtt gtcggagacc cgaaaagcaa caattcaaat aggcttgctc 2109181 aagtgtcaga ggaaatagcc gggacaaaag cataccggat cggcgactta agcgaattga 2109241 agctcgaatg gctgaaaggc gttaataccg ttgcagttac agcgggagct tcaacaccga 2109301 cgccgatcac aaaagaagtc attcgctttt tagagcagtt tgatcacgaa gatccatcaa 2109361 cttggacaac tgaacataat ataccgctca aaaaaatact tccaaaagta aaagcaaaaa 2109421 actgaggctg taaaagcctc agttttttta tagaaatgta aatggatttg tatctgtttc 2109481 agaaacaaag atattcacgc caaacttttt atcattacac attgatgtaa gttttctcgt 2109541 gacgccttct ttcatgattt tttccgcgta atggcccgga tcaaccacat ttaggccaag 2109601 catcatcgca tcatgggcca catggaagta taaatctcct gtgacgtaaa catcggctcc 2109661 ctttcgtttt gcatgatgaa tatacttgtt tccatctccg ccaagaacag ctactttttt 2109721 caccatgctg tcagcatccc caaccattct gacaccattg acgtcaagct tgtctttcac 2109781 aaataaagcg aattccttga gcgtcatctc atttttaagg gttccgacac ggccgagccc 2109841 tttttcggcg ggagtctgtt cgacaggata gatatcgtaa gcgacttctt catatggatg 2109901 gctttttatc attgcattga taacagcctt ttcgacgctt ttaggaaata cagtctcaag 2109961 ccttacttca tgaacaagct caagctctcc cacttcaccg ataaaaggct tagctccgtc 2110021 caatggctta aagctgccga ttccttcaga tgaaaacgcg caatggctgt attcaccgat 2110081 atggccggcc cccgcatttc cgagcgcggc tctgacctgc tcttcatatt ccttcggcac 2110141 gtaaactgcc agctttttca gaggatccgt ataagtaggt gccagcactt ccgtctcact 2110201 cagctctaat gcttcagcaa gcaaatcatt cacaccgccg tccgcaacgt ctaaatttgt 2110261 atgagctgca taaacagcaa tatcatgctt caaacacttt tcaattaacc ttccggcagg 2110321 ctgatctgtt gaaatatgct ttagcgaccg gaaaattggt ggatggtgtg caataatcaa 2110381 gtcaacctct ttttcaatcg cttcatcgat aacgctctct aacacatcaa gtgtaaccat 2110441 cacattttta attggtttgt ttaaggtgcc gatttgcagg ccgattttat ctccttcaac 2110501 cgcataggct ttcggggaaa attgttcaaa cagctggatg atctgctgcc catttacact 2110561 tttagccatg atcgattacc tcctttaaca gctccattcg atcggcgagc tcctttaatt 2110621 tttgtttgtt ttgctctgta tccgccgctt ggctgatctg ttcataaatg ctttgagtgt 2110681 gctgaagctc ttgtgtccac tttttcaaaa agacagcatt tttttctttt gccaagaaag 2110741 ggccaacgag catcccggct gataaagaaa taccgtcata agccgcatcc ctgtctcccg 2110801 cttctgccac cagcacctca tagcactttc cgtcctcttc aaggattacc tcatctatca 2110861 gcgcatatct ttctttataa agccactccc tgatatgaac agcatgaata ttcggctgta 2110921 aaatgagccg ttccttcccc gttaatttgt ctttgcccgc ttctaaaatg tgagcgatca 2110981 aagccccgcc cattccggca atcgtaatgg catcagcttc acctttttta atcacttcca 2111041 gtccgtctcc ctgccttaca gaaatgtgcg agtttaagcc tgatttttca acctgccgct 2111101 ttgcagacaa aaatgggccg tctgttattt ctccggcaat cgccccgctg gctttatgat 2111161 tcagcaccgc ataacaagga aggtaggcgt ggtcagagcc gatatcggcc atcaccgctc 2111221 cattcggtat gtactccgct actgtttgca atcgtttaga taattttaat tcgttcactt 2111281 gtcatcacaa cttttctcaa tcattttttc ctttactatc atataaaaaa tcagcccgga 2111341 atccaagctg aagcaaatga ttttgaaatt atttcttttg atgcgggtct gcacgcagca 2111401 gtcaaaaata aaaggctgtc gagaacatct cggcggcctg tgaatgtata aagagaaaaa 2111461 tagttctttt atttaatttt tgacacccac tctgccatat catccagctt atcggccgga 2111521 acaagaccgg aaggcattcc attaccgcct ttttcgatct ttgttttaat ttcagcgaca 2111581 tctttcttat cccctacacc ttttaagcta ggacccgaaa caccttcata attttcaccg 2111641 tggcatgcga tgcagtttgc cttgtaaatt tcttctggtg aagcgtttgc atctttcttt 2111701 tcagcagatt tgctttctcc tccgctcgca atctcccgag agtcatcaag tccttttact 2111761 gataaaaaga aagttagacc aattcctaaa acagcgatca gcaaaaatgg aataagcggg 2111821 ttccatttca tttcccttcc ccctttttga tccttccccc tatgtaaaca cttctaattc 2111881 taacttattt ttacaaaaag taaatggatt gctatacaaa agttttttat tcacacttta 2111941 tacaaaattg aatagaaaca tgcctaaatc tctaatatcc tttttattct attgtataat 2112001 gtattgtata cgcttacaat agaaaatatg gaattagatt ttgaaatttt tcaccacaat 2112061 gttcatttgc aaatgacatc atttttcagt aaaataaagg catattatcc atatatcttt 2112121 ttaaaaaaag aagaacggat cttcaagacc cgttccatct tattcaagga aatctttcaa 2112181 acgtttactt ctgctaggat gtcttagttt ccgcaacgct ttggcttcga tttgtcgaat 2112241 acgctctctc gttactccaa atactttgcc gacctcttct aatgttcttg tacggccgtc 2112301 atcaagaccg aatcgaagac gcaatacatt ttcttcacga tcagttaacg tatcaagcac 2112361 atcttccagc tgctctttca atagctcgta tgcggcgtgg tcagaaggtg aagttgcttc 2112421 ttggtcttca atgaaatcac caaggtgcga gtcatcctct tcaccgatcg gtgtttccag 2112481 agataccggc tcttgagcaa tctttaagat ttcgcgtact ttttcaggcg ttaaatccat 2112541 atcttccgca atttcttcag gtgttggttc tctgcctaag tcttgcagta attgacgctg 2112601 cacacggatt aatttattaa tggtttcaac catatgaacg ggaatccgga tcgttctcgc 2112661 ctgatcggca atggcgcgtg taatcgcctg tctgatccac cacgtagcat acgtactgaa 2112721 tttataacct ttgcgataat caaatttttc aacggctttc atcaggccca tgtttccttc 2112781 ctggatcaga tcaaggaaca gcataccgcg tccgacatac cgttttgcga tactgacaac 2112841 aagccgcagg ttcgcttcag ccaatctgcg tttagattct tcgtcacctt cttcaatctt 2112901 ttgagcgtag gcgatttctt cttttgcaga aagaaggtta acccgaccga tttcctttaa 2112961 atacatacga actgggtcat tgattttaac gccaggcggt acacttaggt cattaaggtc 2113021 aaattcttct tcggctttgg caagctgctg aatattagga tcttctgttt cttcattctc 2113081 actaattaat tcaacacctt gttcacctaa aaattcataa tactcatcca tttggtctga 2113141 ttcaatttca aagctggaca tacgctcagc aatttcttca tatgtcaaaa cgccacgttt 2113201 tttaccagac tctgttaatt gctcttttac ttggtcgaat gttaattctg tctcgtgggt 2113261 ttgtttatca gccattatgg atccctcctt ccaaagcttg caacgaattc tataagcggt 2113321 atgattctta ttcggtccat tcaggcgttt tctatgtgaa ctgcctttaa caatgtgcga 2113381 ataatgaaat gacaattcat gatgaggtta agcgatctat ttgctcctcc gcaaggaatc 2113441 attgccaata aatgctcctc atcagttctc cagttatttt aaagatcggt tcaatgtaac 2113501 gatttcttga gccaaagaag cagctcttaa aaaatctttt tgcctttctg cttcggctct 2113561 ttccgcctct ttttctttta tcattgacca atttctttga ttcaacactt tttttacata 2113621 atctgataac tcggcttcgc taagctcttg attaacctga agcattaata tatcggacaa 2113681 gagctggctt atatgatcat ccgtcaccct ggccatcaga tgctgaggcg tcagctcggc 2113741 tccctcttca taaaaagcat aaagataagc ggctaatgcc cggtgctcat caatattaaa 2113801 ttgaaaccct acccggtcaa tcactttttt gatgacgctc cgatctcgaa gcatgtgagc 2113861 gagtaacagc ctttctgcat tttcatacgc cggacgcaaa cgtttttgcc ttgcttttgt 2113921 cgtcagatgc gctcgccgcg ttttagtttc accgctattg tcagcaggtt tgttttgctt 2113981 gctgaaaaca gacagctgct cagttaaaga ctcctgtgaa agcgaaaact ctgaagcaag 2114041 ctgctttaca tagacttcct gctctagaga ccctgaaagc gtgctgattt ctttcagtac 2114101 gtctttaatg taagctaggc ggtcgccttc atcggacagg ttctttcctt ttcggaaata 2114161 ttgcattttg aacgccatta cggtgacact tgcgtcaata atgtcgtttt taaatttttc 2114221 cccgccgaat tttttgatgt aatcatcagg gtccaatccg tcaggaatca ttgcaactct 2114281 gactttgcag cctttttttt gcagaagctc cgaagctttt aaggtggctt cataaccggc 2114341 tttatcagag tcatagcaaa gaatgatttc ttcgacgttt cttctcagga tcttgacatg 2114401 atcatctgta agagacgttc ccatcgtggc tatgctttcc tttacatccg agcttacggc 2114461 cgatatgaca tcagcaaacc cttcaaataa gactgctctt tcctgctttc tgatatgaag 2114521 gcgggcctta taaaaattgt aaagcagttt gcttttatga aagagcgggg tttcaggact 2114581 gttcatatac ttaggctgct ggctgccaag agccctgcct gagaaagcaa caacagcccc 2114641 gtgatgatca tggatcggaa acatgacacg gtttctgaag cggtcgaaat atccgcttcc 2114701 gtcttcgcgt ctgatcagga gacccgcttt ttccatttgc gcctcactaa atcccctctt 2114761 tacaaggaat ttcgtgataa agtcccaaga atcaagagca tagccaatct gaaattcatt 2114821 aatcagctct ttcgtaaagc ccctagaaag cagataatcc agtgcctctt gaccttcttt 2114881 tgtatttatt aacaaatgat ggtaaaattt cttcaggagc tcatgtgcct cagccatttt 2114941 ttgttctcca gaagactctg gccgggctcc ggaatggact gttatatcat ctggaaaatc 2115001 aatttggtat ttgtcagcaa ggtgagaaac cgactcggca aaagaatagc cttccatctg 2115061 ccttaaaaaa gagaaaacat tgccgcccgc tccgcagcca aagcaatgaa aaatctgttt 2115121 gtcgggcgat acggaaaacg aaggtgtgct ttctccatga aaaggacaga gtccaaagta 2115181 gtttcggcct tgcttcttta attgaacata atcacctatg acttcaacga tatctgccga 2115241 cttttgcacc tgatccacaa tttcatctgg tatccgattt cccatcttat aacactccgt 2115301 cgtacattat tcgatgcttt agtgcaaaat cccttcatcg ttcgacagga ttttttgcag 2115361 cagtgtaata aatcgttctc gatcttcttt attcaatttt ttaggccctt tggcatatac 2115421 gccttttctt ctttgtttgc cggaaaaatg acggccctct agggcaaaat caatcgtgtc 2115481 ttccttgtaa agacgacctc tttccgacat aacagagaca tttctgttca acagcagaga 2115541 tgctaatccg atgtcctgcg tcacaacaat atctcccggt ttcacgtgat ttgcgatata 2115601 taaatcagca gcttctttat gaggatcaac atacttccat ttttcttcat tgcttctgga 2115661 aagctgataa tgttcaaatg aagcgacaaa aagaacttga acttcatact cggatgctgt 2115721 ttgtaaaatt tcatctttta ccggacaagc atcagcatcg acaaaaatcg tcttttcttg 2115781 ttcattaaga agagtaattc tccatccctc cattaaactc ctgcataaaa gcaagcaaaa 2115841 tcgcacatcc tttattattg tggatgtata tgaatttgtc gaaaaatttc cgggagaaat 2115901 tcttgacatc ttacccataa tagtttattc gtatcacacg atccttaaac ctaaaattaa 2115961 tcattttatc acaatttttt attataatac aaacttcaca aagatgctat tgtttttcat 2116021 tattcccttt tggcacagcc aaaaacccag gatagagcgt cctgagttat atgttttttg 2116081 ttttgagatg atggataata tttgctgttt cctcaaccgc tttatttgaa acatcaacaa 2116141 cctggcagcc gatccgatcc acaatctttt cgaaatactc gagttcctct ttgattctgt 2116201 tgatatttgc ataaatcgct ttatcattaa gcccgagtga ttttaaacgt tcttttctga 2116261 tatgattcag tttatcaggg ctaatcttta aaccgatgca ttttttcgga tcaacgttaa 2116321 agagttcttc cggcggatca acctccggta caatcggaac attggcaacc ttcaggcgtt 2116381 tgtgtgcgag atattgagac agcggtgttt tagacgttct tgacacgccg atcaaaacga 2116441 tatcagcttt taaaatccct cttggatcac gtccatcatc gtatttaact gcaaactcga 2116501 tggcctccac ttttttgaaa taatcttcat caagctggcg cacccgcccc ggttcgtatt 2116561 tcgctgttaa accgtaggct gtttccattt tatcaatcaa cgggccgata atatcataat 2116621 ataaaacatt tgctttttcc gcttcggcta tcaaatattc tctgatttcc ggcaccacga 2116681 gtgtaaaaca gataatgccg ccgtctgcct ttgcaagtga aatcacttca ttgatagtgc 2116741 ctatatcttc aacataagga attcttctta catgagtatc atccgccgat ccgttaaatt 2116801 ggctgagtgc tgcttttact accaattcag ccgtttcacc gacggaatcc gatacaacat 2116861 agatgatgcg gttattcata ttatcccccc gttagtttgc aatcttatag gatttcattt 2116921 tcagataaac tgacaagtat tttggtcata tttgtttttg tcactctgcc gatcacttca 2116981 aagcctttat cggtgtcttt gatgacaggc agtgcatcaa tttgtttttc tattaagtgc 2117041 tttgcaatgt ccatcacata atcctcgcgt ctgcacaccg taatgttcgg catccttgtc 2117101 atgatgatgt gaacagggac cgatgtaagc tcctgctggc caatgctcgc tctgagcaag 2117161 tcttttcgtg aaagcacccc gactaaaaca gcatcgcggt ccaccacaaa cagagtacct 2117221 acatcttcta aaaacatggt gcaaatcgca tcgtacacag aaacgttttc gtgaatcact 2117281 acggggatag attgaaagtc tttcacctga agctttttga gtttatccgc caaaagctgt 2117341 gtgccggttt ttcccgtata gaaataaccg actctcgggc gcgcctcgag gaatcctgac 2117401 atggtgagta tggctaaatc cgggcgcaat gtcgccctgg ttaggttcag cttttctgca 2117461 atatgctccc ctgtaatcgg cccgttttct tttacaatct gcaaaatatg ttcttgccgt 2117521 ttatttagtt cgatcgtact caccaccttt tcacttcata gctatgtaaa gaaataacaa 2117581 tccatattat aacgtaaata tcttgtaatc aaacaaaaaa cttataaatg gggaaaagac 2117641 gattaccgat cacacagcaa ccgccttttc tctctttatt ttacaataag ggcattcata 2117701 ttcgcaaagg acttgatctc atccgccaag cttaccattt gcgctaaacg atttgccttt 2117761 aatgactcat tatccgctat aaccattgta tgatcgaagt aagcatcgat cggttctttt 2117821 aaggctgcaa gtgaagcaag cgccgcctca taatcttttt tgctgaagtt ttcctgcaga 2117881 ttttgcttcg ctgtttggta ggcatcaaac agttttgctt cgtattcatt ttcaaacaga 2117941 tcaggctgaa tgtctccgcg gactcctttt ttgctgatag agatcactcg gcctaacgct 2118001 tcggctgttt ccttaaagcc aggtgcacca agcttttgct ccagtacttg tgctttatgc 2118061 agcgcagagt acggctcaag ctcagagctt tccagcacgg cgtcaatgac atcatgtctg 2118121 atttgttcag cattcaagac atatttcaag cgctgagtga agaaatccag cagttcattt 2118181 tctttatcgg tttgaacgaa agtaagcagc tcttcaaatg aaattcccca gttgcggtca 2118241 agaagaatcg caacaatacc gcttgcttgg cggcgcagtc cgtaagggtc ctgggaaccg 2118301 gtcggaatta cgccgataga gaagaatgaa gcgattgtgt caagcttatc cgccattgct 2118361 acaacagctc cggtgaaagt agaaggcgtt tctccgcccg ctgatctagg catataatgt 2118421 tcattaactg ccgcagccac agcttcatct tcgccaagca ttctcgcata cttttcgccc 2118481 ataattcctt gaagttcagg gaattcatat atcatatgcg tcacaaggtc gaatttagaa 2118541 atttcagcag cccgcttcac atgttttaat gtatcttcat cagcctgaag acgaacggca 2118601 agtttctctg cgattgatgt gactctccta accttatcag caagagaacc aagctcttca 2118661 tggaaaacga tattttcaag cttcttcaca tttgcatcaa tgtttagttt ctgatcttct 2118721 ttgtagaaga atgaagcatc agataaacgt gcgcgcagca ctttttcatt gcctcgggcc 2118781 acattttcaa tcgcgtggct gttgccgttt cggactgtga taaagtgagg cagcaggtca 2118841 ccgtttttgt ctttgacagg gaagtagcgc tgatgctctt tcattgtcgt gacaagcact 2118901 tcttcaggaa ttgacagaaa ctcggattca aatgaaccgt aaagagctgt cgggtattct 2118961 actaaatgat tcacttcatc aagaaggtct tcgtcaactg gaatgctcca attgttttca 2119021 gcagccattg tttccagctg agattgaatc atttgctttc ggacgctagg atcagcaata 2119081 acatgctgtc ctttgagctg ctcttcataa gctgaaggtg attcaattga cacttcatgt 2119141 ccgaggaaac ggtgtccctg tgttgtccgt ccagactcaa cgtttgtgat cgaaaatgga 2119201 atgacatcct gtccaaataa tgcgacaatc catttgatcg gtcggatata acgcaaatct 2119261 tcatttcccc agcgcatgtt tttcgggaaa tgcaagcttg taattaaacc gctcaattct 2119321 ggcagaagcg acttcgtttc ttggccggct tggaattttt gcacgaatac atactctatg 2119381 ccttttactt ctttgatgta caggtcttcc acatttgcgc cttggccttt tgaaaagccg 2119441 attgccgctt ttgtccagtt cccgtccgca tcaagggcaa tttttttcgc aggccctttt 2119501 gcttcttctt ttatatcatc ctgcttttct gcgacatcct taacgaacac agcaagacgt 2119561 ctcggtgtat tgaagagttt cacttcaccg tgagtaatat ttttttcttt aagccagcct 2119621 gtcagcttgt cgccaagctg aaccatgctt tcattcaaaa agcgcgccgg catttcctct 2119681 aatccgatct ctaaaagtaa atcctgttta ctcatgagaa gaaccctccc ctttaagcat 2119741 tgggaaccct agtttttctc gttcctcata gtaggttttt gctacttttc tagctaaatt 2119801 ccgcactctt gcgatatagc ccgtccgctc ggtaacagag atcgcacctt tggcatcaag 2119861 caggttgaaa gtgtgcgagc atttcagcac atagtcatat gctggatgaa caagtccgtt 2119921 gtccatttgc ttgatcgctt ctttttcata tgtgctgaac aattggaaca gcatatcgac 2119981 gtctgatgtt tcaaacgtat aaacagaatg ctcatattca gccatcatga ataaatcttt 2120041 tactgtaaac cctgacgtcc attccaagtc aaacacgttt tctttatcct ggatataaga 2120101 cgcgagacgc tcaattccat acgtaatctc tacagaaacg ggtttacact ctaatccccc 2120161 gacctgctgg aaatacgtaa attgtgttat ttccattccg tcaagccaaa cttcccagcc 2120221 tagacccgcg cagcctaaag acggattctc ccagttgtct tcaacaaagc gaatatcgtg 2120281 ctcaagcgga tcaattccaa gagcacgcaa ggaatccaaa tacagctctt gaatgttatc 2120341 aggtgacggt ttaataatga cctggaactg atgatgctga tacagtctgt tcgggttctc 2120401 cccgtagcgg ccgtctgccg gacgtctgga aggctctaca taagccactt tccacggctc 2120461 aggaccgata ctgcgcaaaa atgtatacgg gctcatcgtg ccggctcctt tttctacatc 2120521 gtaagcctgc ataagcacac agccctgact ggaccaatgc ttttgcaagg ttagaatcat 2120581 gtcttgaata ttcatttcaa gcacctccac ttttctttca taagttgact gcggcagcaa 2120641 ccaaaaaact cccgtctcta tgcttgccag ccgcaaacat agggacgaga gttctcccgc 2120701 ggttccaccc tagttgctga gaacaaaatc ccagcctctt ttttaaaatt gctcaagaat 2120761 gcctttcgtt gcgtgctcat ccttagctta caccgcccta aggtcgcttt catgaggtaa 2120821 acgcaagtac ttctttctct cactgcaaca tattttataa taaatgatca tataaaaaga 2120881 tggaccaaat gtcaactttt gttttcaccc ataagatgtt tcatgctttc catttgatct 2120941 aaaaagcgct ttgattttaa atacaatccc gaatattctt cgtaatataa atcaatcact 2121001 tgctttaatt cagcttttgt ttcctctttt aaggacacat tgccgagtct cgacagatca 2121061 aaatagtaaa agagccttaa cagccttgcc gtttgcggtt taatcggtat cctgtaagga 2121121 tctttttcaa aacagcggtg gcatataaaa ccattatcac gaacagagaa atgaaaggtt 2121181 ccgtcttggc ttttacaatg tacacaatga ttcagctcag gatacaggcc catgacaccg 2121241 agcatcttca tttgaacaat gaaggtgata acatccggat ctgttccttc attcaactgt 2121301 tttaatgatt ctaatatgaa ttcaaataaa taaggatttg gctttttttc ttctgtgcct 2121361 ctgtcgacta actcagcaac ataggcagca tatgctgtta aaaacaagtc ttccctgatg 2121421 cctctcatgc tgaggatcat ttccccctgc tgaagcgttc cgaggcccga tgttttttgc 2121481 attaagaaag aaccatacaa aaagggctgg ctgactgctg ataaacggct gttcggtttt 2121541 ttggcgcctc gtgccataac acctattttt ccgtgttctc ttgtcagtaa tgttacgatt 2121601 ttattcgtct ctccgtaatc atttgtgcga agaacgatcc cttcacattt tgtcagcatt 2121661 tccgcacctt cctcaagcag gagcggccaa gaggtttata aaattggata atcaaatcgg 2121721 gctagctcat cttctagttc ttcgggtctt tccatgttct ctttttccag ttctttaaaa 2121781 agaagatacg tatcaacatt tcctgtttga gaaaatacgt tccaggtaaa attcaacaca 2121841 agaaacccac ctttctgtag ttaaactagc ttacctaaac tccaaattct tacctttatc 2121901 ttgaccagat gtcctccatt tcatgttaaa caaaatttgc taatgtatcc ctgttcctgt 2121961 gagataatga cacacacggg aagagattaa tattcgtcct ctttaaagcc aaaatcgcga 2122021 agctgggaca ttttattacg ccagtctttc tgcactttca cccacaattc aaggtagaca 2122081 cgggagccca acagtgcttc aatatccgct ctcgctcttt ttccaacctc ttttagaagg 2122141 cttccttttt taccgatcac gatgcctttc tgggaatccc gctcgaccac aatcgttgcc 2122201 gctacgtgca cagaaccgtt gtcctgccct ttgatggatt cgatggccac cgcaatgctg 2122261 tgcgggattt cttctctcgt caaatgcagc accttttccc tgattaattc agaaatgata 2122321 aatcgttcag ggtggtcagt tacctggtca ctcggataga attgcggccc ttccggcaaa 2122381 tacgcttcga tctgcgcgag caaggtttcg atgttatttc cttctaaagc agaaatcgga 2122441 acaatttcct taaaaggata acgtttgcgg tattcgtcaa ttagcagaag caattggtcg 2122501 ggatgaattt tatcaatttt gtttacgatt aagaatacag gcgtagacat cgtctgcaat 2122561 ttctcaatga tgaattcgtc gcccttcccg tagccttcct cagcattgat cataaacaag 2122621 atcaaatcga cttcttttaa tgtattttgc gccactttca tcataaagtc cccaagttta 2122681 tgcttaggtt tatgaatccc tggtgtgtca ataaaaatgg tttgtgatgt gcctgtcgtc 2122741 agtactcctt gcaccttgtt tctcgtcgtt tggggcttat cgctcatgat cgcgattttt 2122801 tgtccaatga ctctgttcaa aaatgtagat tttcctacgt ttggtcttcc aataatggat 2122861 acaaatcctg atttaaagct ttcgttcgtc atgtaaatcc tccgatgaaa atgcgcctgg 2122921 caataattct tccacagtca tttcttttat ttgtccttgt aaattagtca gtacgacaat 2122981 aacgtctttt gtgcaaagct cagaaatcac ctgtcggcag gctccgcacg gagatactgg 2123041 tccaggggtg tcagccgcaa cggccagcat ctgaaactct gtatcccctt cagaaacagc 2123101 tttaaataaa gcggtacgct cggcgcaatt gcacatgctg tatgccgcgt tctcaatatt 2123161 gcagcctctg tacacttttc catccttggt aagaagagcg gctcctactt ggaatttgga 2123221 atacggcgca tatgccatat cacgcgcttt taaagcttct gttattaatt cttgtctgtt 2123281 catgtgtaca ttcctctctt acctataatg gtaccgctat cactttatat tttacataat 2123341 cgcgcgcttt ttttcacgcc catttctaaa aatgtaaaat aaatgtaaga attttcagcc 2123401 attacagctt tggcaaaaaa ataagtaaac caatgataca cgaaatcacg gcaaaaacgc 2123461 aaacagcccc ggcggcagcg tccttggccg ctttagcaag agggtgatgt ttgtcagtta 2123521 ttaaatcaac cgtatgttca atggctgtat ttaaaagttc aagcgaaaac ataccaccta 2123581 tcaaaaggaa tataatcatc cactcaataa tgctgagctc tacaaggaag ccgcaaatga 2123641 gaacagcgca ggcggctgcg gcatgaaatt ggaaattccg ctccgtccgc gctgtttccc 2123701 atatgccccg gcctgcatgc acgaagcttt tgaagaatcg attcagctca tttctatgat 2123761 cttttgagtc cataagcgtc cagcaattcc ttttgcttag taaacatctc ctcttcttcc 2123821 tctttcgtca tatggtcata tcctaaaagg tgcagaaatc cgtgtacagc tagaaatccg 2123881 agctctcttt taaaagaatg attatactcc tctgcctgct ctcttgtgcg atcggcactg 2123941 atgataatat cacctaaaac cggaggcatt tcggcgccca cgatttcgat ctcgccttct 2124001 ccctcttctt caagagcaaa tgagatgaca tctgtcggag catcctttcc ccggtattct 2124061 ttgttaatct gatgtatgtc atcattggaa acaatcgtga cagaaacttc agcctgatcc 2124121 tgaacgcctt cacgctcagc ggcaaattga agcagatttt ctacttcttt gagcatctct 2124181 tctgagacgc ttcccgtttc atcaacgata tcaatcagta aactcatcta tttcaccttc 2124241 ttagtagcct ccggatattc aatccgggag tggaaaattc cttttaatgt tgcacagagc 2124301 gtttttgcga ttgtatccag ctctttaaat gtcaaatcgc attcactgaa ctgtccgtcc 2124361 tgaagcttat cggatataat accccggaca agcttttcaa ttcgttcagg atttggattg 2124421 tgcatggatc tgacggccgc ttcaacactg tcggccactg atataattgc ggcttccttt 2124481 gactgcggct tcggtcccgg ataacggaac tcttcctctg taatctggtc gcctttttcc 2124541 ttcgctttat agtaaaaaaa ctttaaaagc gaggttccat gatgctgctc agcaatatcg 2124601 acaagctctt tcggaaattt atagcttctc agcatattcg caccgtctgt cgtatgcgag 2124661 ataataatat ttttgctcaa ctgaggtgac agcttgtcat gcggattgtc aatattcatt 2124721 tggttttcaa taaaatattg cgggcgcttt gtttttccga gatcgtgata atatgcgccg 2124781 actcttgcaa gcaaaccatt agccccaacc gcttcacagg ctgcctctga taaattggca 2124841 accattacac tgtgatgata tgtacctggt gtttccgtca gtattttgcg caatagcgga 2124901 tggttaggat tagacagctc gagcagcctc atggtggata aaatgccaaa gcccgtctca 2124961 aaaaacggca tcagaccgat gatcaataca gatgaagcaa accccgacac aacccccatg 2125021 agcattaacg tgccgatttc aagacccgac agcgcagtgt tctggatcaa taataaggat 2125081 agaacgacaa ccatattaat aaacgccacg aaaagtccgg tctgcaaaat ctttgatctt 2125141 gcattgtgtt ttcctaaaaa taatacacct gaaatgccgc tgatcaaata ataaatccct 2125201 atgacataat tgaatgttcc tgtcacaccc tgattaaaca tcatacttcc gcaaatcgca 2125261 agaatgatac ttcccaaaat ggcaatgcgt tcattcatca gcagtttgat taagatggcg 2125321 ccggccgcaa tggggaccag atagccgata ttattatact ccatcttctg aaacaaactg 2125381 acaacctcca tgatcacaag caaaagtgtt gtgattatgg agaataacag aatggattgg 2125441 tttttaaact tcagattttg tttctgtttt tcaaaataat atacaagtgt tgcaatgaaa 2125501 agtccgatca taatcaatag cccgctgatc ggtttaaaga gatttgagtt atttaataac 2125561 ccggtcagct caagtttcct gtacacttcc cgatcaatga ggtcattttc ttccacgagc 2125621 acttgcccct gtttgatttg aacctgctgg acattatctg aggcttcctg ccgttttgcc 2125681 tctgttgctt tcggatcgaa gacgtaattc ggaataatag caaaacgccc gatttctgtc 2125741 gcggctccca agtatttaga cggaatagaa ttgctcttta gctctttttc taccttatcc 2125801 tttgcatcag atagtttatc cgaagggatt tcactgctca tgaccgtatt taccgcggta 2125861 atgaccgtat ctctgacaaa agaaaagtct tcactgtctg ctttcagcaa tgtcttgatg 2125921 gaatcctccg atatagaatc attcacatct gatgtcaatt tgtcctttac agatttgacc 2125981 attgattttt ccgatggtga tttactgcct tcttccgatg attttttcac ttcactaata 2126041 ctgtcgaata ttgatgacac aaggtcaatc cgattgtctg tatattcttt ttttaatgta 2126101 tattgatctt caaccgcgtc ctcagcggct tgcttttttt cctctgtggc tttttgatct 2126161 tctacggttg ccggagcgta aatggtcttg tcgctgactg aaaacaggtc taaatcaagt 2126221 gtttccggct taacatgtac aaagagcaaa gcaaacataa tggcagccag cagaagatac 2126281 agcagtacat gcatggagcg ggcattttta aaactgctcc atttttttga gctgcttttg 2126341 gtcttagcct tctttttcaa cacaagaacc tcctcttgaa acatcaagcc cataagcaat 2126401 cataaaaatg acccgataac gcgcgatcgg gtcattcagc attaattttg cttatcgtat 2126461 gcttcaataa ttttcgcaac aagcggatgt ctgaccacgt ctgtctggtc tagctcaatc 2126521 atagaaatgc cgtctattcc tttcagcatc tccttcgcta ctgcaagtcc cgatttgacg 2126581 cctttcggca gatcaatttg gctaacgtca cctgtaatga tcattttaga gccaaaaccc 2126641 agtctcgtca aaaacatttt catttgagca ggcgtggtat tctgtgcttc atcaagtata 2126701 acataagcat catcgagcgt ccgtcccctc atatatgcga gcggagcaat ttcaatgatg 2126761 cctctttcca tcagacgttc tgtatgatct gccccaagca catcatggag agcgtcatac 2126821 agcgggcgca aataaggatc tactttttct tttaggtcac ctgggagaaa accaaggctt 2126881 tcaccggctt ccacggcagg tcttgttaaa atgatttttt tgatatgtcc gttttttaaa 2126941 gcatggactg cttttacgac agccaggtac gttttcccgg ttcccgccgg accaatgccg 2127001 aatacaaggt cattccgctt catagcggcc acgtattccc gctgtcccat tgtttttaca 2127061 cggattgatt tgccttttgc gttttttgta atttcttctt catacatgct ttcaaagtat 2127121 tcaagttcat tcttctttgc cattttgatg gcgtaaatca catcacgttc agagatctct 2127181 atccccttgc gaattaaagc gaggagcgat cccagcagcc tgtctgcaat ctgaaacgat 2127241 tcatcatcgc ctgaaacata aatcgtctcg ccgcgcgtaa tgatatttaa attcagatct 2127301 ttctccatca atttcaaaaa agaatcttgg ttcccgaaga gtgaaagcgc ctcgtccggg 2127361 tttttcagtt tttgattcat cgcaagtaaa tgttctgtca ttcttcagtc tccctgacaa 2127421 taggtgtggt ttgaacgata tcttctataa cttggtagag aataatcaac tttactttac 2127481 cattctcaac agtctggtgc aaaacttttt cacttttcac ctcgccgttt tcgcctattt 2127541 tatcctctac atcctgttta cccaatttaa tgccttcttg aactgcttct tcttttgtat 2127601 attttcgcaa agcctcttca ctttctctcg tttgctcttt gacataggat acagggagct 2127661 taaatccgag aaaatgaagc gaatgctttt cttgttctgt ttttggatgc ttcaattcct 2127721 cttttttaaa cgtcatcccc cagatcggga ttgccaaaga accaaaagaa agcttgtgct 2127781 ttgtccttac tttgcccgta tagacgttaa ataatgtttc aagcgggact gtcacttctg 2127841 atctatacca ggtttctcca taaatttctg cttttgaggc gacttcctgc tgatggtctt 2127901 cgctgccgat cagtcccgaa acaagcagct gtcccttttc aacatgatcg tgtatggcgg 2127961 ccatgggctg tcctttttgc acaaacattc tcgtaatggt tgctttcttt ttggcgacaa 2128021 tattgcgcgg gctaacatat ttttcttttt cgggctcatt tttctccaca actttcatat 2128081 gaatggtcgt ccccttcaga tcaactccga cccaagtgat attgtctatt ccattggtta 2128141 atgatttctg tattttttcg ggcgacatca ttaaaaactg cagacggccc tttttgacgc 2128201 cgatttcatt aagatgctgc ctcatttgat gttctgtttc aggcttagcg cctgtcacat 2128261 caattttcca caccatattg gacagcaaaa acaaaagaat gaaaaaaatc gcaaaaccga 2128321 tcgtaaaccc tatattcagc tttgatttca gcaacaggaa gggaaatccc ttccgattga 2128381 taaatcgggc tttacattta aatttacttc ttacccgccg aaaggcatgt acatcctgaa 2128441 gctgtatata taacgatacg gcttctttct tttttttgac atgaaagacc ggaatcccct 2128501 gtcttgtgca ttcattaagg agccgctcaa tccctcttcc cgtcaattca agctggacct 2128561 tacccgaaaa aaaagacagc catttatttt tcacaacatt tccccctcgg ctttatgact 2128621 caacatatcg aacgacatca atcgtaccct ccaaaagtat ctcttccgga agaatcgcct 2128681 tgatgacaaa atttttacca gatatgatgc actggccctg cttcagcatc agccgcactt 2128741 cattctcact gaaaagcaaa aggcctctgt ggttttctat gtagatatga agtctgccaa 2128801 ccattgtaat cctcggcaga tccatcataa cgtccggggg aatttccaat gctcttgtca 2128861 gccaagcttt catacgattc tttctttgcc ccatacaaaa agaaccccct ttcatctcat 2128921 atgtatgatt tgaaaggagg ttctaacact ttaattttta cgggccgggc gcatcgtacg 2128981 gtgaggtttt ttcgcccgtg gaggtccgaa cacctctcct agaacgatcc cctgtacgac 2129041 ggtgtcttta ttcacctgaa gcattttttg ttttgtgtat actgtttttt gtttggcagc 2129101 agcaagatct cgttccagcc ctttcaggtt tcttgctgtt tccctgcgtc tttcttccgc 2129161 ttcccgtctt gcctgttcca tacggttagg gataggtgca ggggcatctt cttttgactg 2129221 cttcttttga ggagaagcag attgcacgtg ttgaggtttt tttctttttt ggctgttttg 2129281 cttttcttct ttgctctttt tgccgaaaat cgcagaaatg attccgatga tcgctgcaat 2129341 aataagcgga ttggtcagta aatcttccat cagcgttctc ccttcttaga gagattatga 2129401 tttgcggtct tcatccgaag ggtctttcgt cagcttgccg aatgaatcac gcatttctgt 2129461 gtcagcatcg atgttcttga tattcatgta atccatgacg ccaatattcc cttcacgcaa 2129521 agcttctgcc atcgcaagcg gcacttccgc ctcggcttct actactttcg cgcgcatttc 2129581 ttctacgcgg gcacgcattt cctgttcttg agcgacagcc atcgcacgtc gttcttccgc 2129641 ttttgcctgc gcgatgtttt tatcagcctc ggcctgatcg gtttgtaaaa ttgccccgat 2129701 gtttttgccg atatctacat ctgcaatatc aattgagaga atttcaaacg cagttcctga 2129761 gtccaatcct tttccaagga ctgtctgaga aatcatgtca gggttttcaa gcactttttt 2129821 atgattatca gatgaaccga ttgtagaaac gattccctca cctacacgag ctacaatggt 2129881 ttcttcccct gctcccccga cgaggcgctc gatattcgct cttactgtga ttctcgcttt 2129941 cgctttcact tcaatcccgt ccattgcgac gccggcaatg aacggtgttt caatcacctt 2130001 aggattaacg ctcatttgaa cagcttccaa cacgtcccgg cctgcaagat caatggcagc 2130061 acagcgctcg aatgtgagtt caatgttagc tcgctgagcg gcgataagcg cgttgacgac 2130121 tctgtcaaca ttacctccag ccagatagtg gctttcaagc tggtttgttc caacattaag 2130181 tcccgcttta tgcgctttaa tcagcgggtt aacaacccga ttcggaatga cgcggcgaag 2130241 cctcatccca actagagtga aaatgctgat tttcactccg gctgccaaag ctgaaatcca 2130301 aagcattaca ggcacaaatg taaaaaatac tgccaaaaca atgatcgcta ctgcgacaat 2130361 tgccagaatc ataagtgttg acggatccat ataacttctc ctcgtttcta tttaaatttc 2130421 tctcacgaca atgcgtgagc cttctacttt tatcactttt acttttttat ctttttctgt 2130481 aaacgatccc tccgatacaa cgtcaaggcg ttcatcatca ataatcacgg taccggaagg 2130541 acgcagcggt gtaaaggtta tacccacttt tcccattaag tccgtgcgcg tttgatttga 2130601 aacgtagccg ctctccgtgt ttgtagaatc atttaatatc aatttcttaa agaatttcat 2130661 acgctttccc aacacccttg tcagtaaaat aaaagctgta atcgaaacag ctgaggcgat 2130721 caagagagaa accgccatga cagtgaagct ccccgcggct aaaaacaggc tcgcaataat 2130781 cgctcccaag cccagtaatc caatgattcc tccgggaaga aaaatctcaa gcagaatgag 2130841 aatcacccct gctataaaga ggagaaccgt ctcatacccg gcaaggccgg ctgcaagatg 2130901 cccgtaaaag aacagcaata acgcaatgag tccagccgtt ccagggaggc cgacacccgg 2130961 ggaaaaaagc tctaccgtca gacctaaaaa agcgattgtc agcagaatag ggacaatgac 2131021 cggattcgtc agccatcttg ccgtcttttc cgcaaagctc tcctttgcat agctgatctg 2131081 cgccttttcg aacccaagct tctttacgag cgtggacaaa ttgtcagcag tgccttctga 2131141 atagcctacc tcaatcgcct tgtctgcgtt aagtgtcagc agatctccct taggcgcgcc 2131201 aacttccttg gcatctatat ctgggtcagc cattgcgagc gcatattttg gatcgcggtt 2131261 atttttcact gcggcatctt ccatctctgc cagccaaagt gattgagctt tttggtcagc 2131321 ggcattgcct tggccatcaa caatcgcggc ggctcccatt tttccgccag gcgccatata 2131381 aatgtgatct gcttgaagtg caatatatgc accagcagac aacgcgcgtt tgttgacata 2131441 tgcagttacg gggatctcgc tttcggttat caaatcggcc atatcaatag cagatttgac 2131501 caatcccccc ggggtattga tatcaagaat aatatggtct gcatgtgcat cctttgcgtc 2131561 ttgtaacgaa cgggacaaaa acgaggcgag accctgttcg acattttttt caaccgggat 2131621 cacataaaca gtttgttttt ctgcttttgc gttcagctgt acgcctaata aagaaagtaa 2131681 aaatataccc aaaagagcag cacggaatcc tttgatttga agcaagggcg gtgtatccct 2131741 ccttcctttt ataataagtg ccttctcttc atacgtaaca aatgtatcaa aggtttcatt 2131801 tttttatgta taaaaaaaga catctctctt agaaagatgt ccttttcttt gccatttaag 2131861 acagttgact gctcacaagc ttattaatta aacttccgtc agctttacct tttactttag 2131921 gcataattgc ccccatcact ttgcccatgt ccgcttttga gctcgcaccg acctccgcga 2131981 tggtttcatt tacgattgta cgcagctctt cttctgacag ctgctcaggt aaataaactt 2132041 ctaaaatgtc cagctctttt tgaactttat ctactaaatc taaacgatta gcgtttgaaa 2132101 attcctggag ggagtcttta cgttgcttaa gttcacgaga aaggacagtg agttcctcat 2132161 cctcggtcaa actgtctttc ttaagcttaa ttgcttcatt ttgaagtgaa gccttaacca 2132221 ttcgaacgac agtcagtttg tctttctcac ggtttttcat atacagcttc atatcctggt 2132281 tgagacgctc aagaagactc ataaatccac cctcttttag aatttgcgtt ttctagcagc 2132341 ttcagacttt ttcttgcgct ttacgctagg tttttcataa aattcacgct ttcttgcttc 2132401 ttgcaaagta cctgtctttg atacactgcg tttgaagcga cgaagagcat cttcaagcga 2132461 ttcgtttttt ctaacgaccg tttttgacat tctctttccc tccctccgaa tacaccaatc 2132521 gactaccttt aagttacaca tataaacatg tactttgaca ttataatata agccatcagt 2132581 caggtcaact aagtgagttc acttttccgt catgagtgcg actgcctgtc tatataatga 2132641 aagaaagggg ttggtgaata ggatgttaat tctgattagc tttactgctc ttatattatt 2132701 ctttctcgca ggcatgaaca tgcttcgaaa gggcttaatt tcaatggcgt actcaaaaat 2132761 tgaagaacgt ttgcttttat ttacagacca tccgttaaaa gcgtttctta tcagtattgt 2132821 atttacgggg atacttcaga gcagctcagc ctttatggtc attgtcatcg gctttgtaag 2132881 tgcgggcgtt ctttctttta agcggacgat cccgatgatt ctggggacaa atgttggctc 2132941 tacttttaca actgaattta ttgctatcaa aatggatatt gtgatttggg ttcttttaat 2133001 aggaggttta ttgttttttc tgactggcag gtatcctttg aaacagctgg gaacaagctt 2133061 ccttggactg ggcatcatct tcttttgcat cagcggattc agccatcttg ccgggccgct 2133121 gacaaagctg aaaacgggcg ccgacgttct ataccatgtt aacgattcaa actggtccgc 2133181 tttgctcatc ggcatggtgt taactgccat cattcactcc agttctgtct gtatcggcat 2133241 tttgatgagt tttatgaatg aagggattat cggactgaca caggcgatga gcgtcgtact 2133301 cggatcaaat atcgggacat gcattacagc tgtcatggct gctgtatccg gcggatatgc 2133361 ggcgaaacag acagcatatg cccatgtggt atttaacgtg ctaggggtgg ctctagtatt 2133421 gccttttctg accgcagcga ccggctttgt agagcagtta tcacctgatc ccgcacaaaa 2133481 gatcgcgcat ttcagccttt tatttaatgt ggtgacagct cttttatttc ttccgcttac 2133541 aaacttgttt taccgattga ttcaccttct tatcccggct aaataaaaaa atcggtacat 2133601 tttaatgcac cgatttttta ggttaagaag acaaacgcat gtgttcagtt atttcatcct 2133661 caaccacacg gacaaactgt ccttcgttgt aaggataacc tgcttttagg attttgactt 2133721 ttacgatttt gccgatcata tcttccgtac ctttgaaaac aaccttcata taattgtctg 2133781 tgtaaccgac aaacatattt tcttcttctg tttccttaaa cgcttcctca gggataatct 2133841 caagcacttc attttcatac tgagaagcgt attcttttgc aagctggtca gaaagagcaa 2133901 tcaggcggtg cacacgttcg tttttcacgt tttcatccac ttggtcttcc attcgtgcag 2133961 ctggtgttcc tgtacgctta ctgtaaggga aaacatgcag ctcagagaat ttatgttctt 2134021 taataaagtt ataggtttcc ataaattctt cttctgtttc tccagggaac ccgacgatga 2134081 catcagaagt aacagctaag cctggcagtg cttttttcaa tttatttaaa cggtctgcaa 2134141 agaattccat tgtatatttg cgtctcatcc gtttaagcac tgtgtttgat ccggattgga 2134201 taggaatatg caaatgattc actatcttat ctgagcggtc taagacctcg atcacttcgt 2134261 cagtgatttg gctggcttcg attgaagaaa ttctgatccg tttcacgcct tccacacggg 2134321 tgtctaattc gctcaaaagc ttcgcgaagt tgtaatcttt catatcttcg ccgtagccgc 2134381 ctgtatgaat acccgtaaga acaatttcct tatatccggc atcgacaagc tgctgcgctt 2134441 gtttaatgac ttcttcaggg tcgcgggagc ggagcaggcc tctcgcccac ggaatgatac 2134501 agaatgtgca gaaattattg cagccctcct gtattttcaa tgacgctctt gtgcggtccg 2134561 tgaaagcagg cacatcaagc tcttcatata ctcttgcttt catgatgttg ctgacgccat 2134621 taatcggctg gcgttcttct cggtattggt caatgtagcc aagcattttt tcacggtcct 2134681 gtgttccgac tacaatgtcg acaccgggga tcgccataat ctcagcaggt gaggtttgcg 2134741 cgtagcagcc tgtgacacag atgacaccgt caggattttg acgaatggcg cgtctgatca 2134801 cttggcggct ttttttatct cccgtatttg taaccgtaca tgtattaatg acatatacat 2134861 cagctgtttg ttcaaagtct cttctttcat agcccgcttc tttgaaaagc tgccagattg 2134921 cttctgtttc ataatggttg actttacagc caagcgtatg gaaagcaaca gttgccatta 2134981 ctgatcacct cttaataact ctgtttgata agaaatcgca ctcaacgcgt atagcggagc 2135041 ggtttctgtc cttaaaattc tcggtccaag gccgcacgtc acaccgtctt gctctgtgag 2135101 ccgttcaacc tccgcttctg ttaaaccgcc ttcgggacca aatacgatca atagagatga 2135161 tcctttcgga aggctgctta caatcgcgct gaatgcgctt atttcccctt gcttcgatga 2135221 ctcctcgtat gcaacgacac atttatcgaa atcctgcatc ctttgaagaa gctgctgaaa 2135281 agaatggaca tccatcactc gcggcacttc gttacggtac gattgctcag ccgcttcctt 2135341 cgcaattttc gtccatcttt cccgcttttt ctttgccttt ttgtcatcca gcttgacaac 2135401 agaacgcgcg gcttggaaag gaataaaggc atgagctccg agctcagtcc ccttttggat 2135461 aatccattca agcttatctc ctttcggaag gccgctcgca atatagacct ttatcggaag 2135521 ctctctgttt tcattcgtcc attctatcac aaggcaggac actttatctt tggaaacaga 2135581 ttgaagttca cattttgcct cgaagccgtc ttgagagcag cagataatct gatctccctc 2135641 attcattctc atcacgttca caatatgatg aacttcttcg ccggtaatcg aaaaagtcgg 2135701 cgcttcctct atttgctgct tcgtgagctc gataaaatat cgttgcatac gctgtgacac 2135761 ctactaactg ttattttttc gcaataatgc tgacccaatc ttccattgaa aggatttcta 2135821 caatggtaaa gccagcttgt tccagtgctt cttttacttc ttgtttttta tgaccgatga 2135881 ttcctgacgt aataaagtga ccgccttctt ttaacaggct gtacgcttgt gaagtaaagc 2135941 gaagaatgac ttcagccaaa atgttggcca caatcacatc atgttcccct tcaatcccgt 2136001 ctaacaaatt gttttgcttc acttgagcaa tatcgctgac tttgttcagc ttgagattga 2136061 ggcgtgcact ttctacagcc acgggatcaa gatcgtaggc atgaaccgat tcagcctcaa 2136121 gcattgcagc cgcaatactt aaaattcccg aaccagtgcc gacatcaatc accttatcac 2136181 ccttttgcac aaagcgttca agcgcctgaa tgcagagtac ggttgtcgga tgtgtccctg 2136241 tgccgaaagc cattcccggg tccatttcaa taatcagttc atcagtatgg accggcgtat 2136301 attcctccca cgtcggcaca attgtaaact tttcagaaat tttcacagga tgataatact 2136361 ttttccaggc agtcgcccac tcttcttcat ttacttcaga aatagtgatg tggtttctgc 2136421 ccaaatcaat attgtaaaga aggagattat taatcgtttc tttgatgccg tctacagttt 2136481 cgcccagaaa actgttaacc ggcagatatg ctttgacaat gacaccctca tctgggtaat 2136541 cattggggtc gagctggtag atttccccgt acacattctc acgttcttta attaaatcaa 2136601 gcgggtcctc tatcacaacc ccacttgcac cagcttcatg caatatattt gagataggtt 2136661 cgaccgcttc atgtgttgtg tgaatgctta attcggacca tttcaaaact accaactcct 2136721 catccaataa ttaatcgcct ttaaacgcgc gttttacctt gtcaaagaaa ctcatttcct 2136781 gttcgtcagg caggtttccg ctgacttcgg caaattcgcg gataatgtct ttttgtttat 2136841 cagtcagatt tgtcggcgta acgacgcgga cgacgatatg ctggtcaccc tgtccatagc 2136901 ctctgacatt ttgaacgcct ttgcctctta atctgaattt cgttcctgtt tgtgtaccgg 2136961 ccggaatttt caatttcact tttccatgca gcgtcggcac ttctacctca tctccaagag 2137021 cagcctgagc aaacgttaac ggcatttcac agtaaatatc atcgccgtca cgctcgaaga 2137081 actcgtgtgc gcgtacatgg aacacgacaa ataaatcccc ggcagggccg ccgtttattc 2137141 ctggttcacc ctgtcccgag agacgaagct gctgcccgtc atctacaccg gctggaattg 2137201 tcacattgat tttcttgcgt tttttgattt ttcctttgcc gccgcagtcc gcacatttgt 2137261 ttttaatgat tttgcctgta ccttcacagt ggtggcagac ccgtctgtta acgacttttc 2137321 caaacggtgt attttgctcc acgtttaact ggccggagcc tccgcagtgg gagcatgttt 2137381 ctggatttgt tccaggtttc gcacctgagc ctttacatgt ttcgcacgtt tcctcgcggg 2137441 gaatttcgat ggttgtttct ttaccgaaag ccgcatcctc aaacgacagg gtcatcgtat 2137501 actgtaaatc agcaccctgg cgcggagcgt ttggatctct tcgtcttgtg cctccgccga 2137561 atatacttga gaaaatatca tcgaaaccaa aaccgccgaa atcgccgccg ccaaaacctc 2137621 cgccgccgaa gccttggtta gggtcagtgt gaccaaattg atcgtaatgc gcacgttttt 2137681 ggtcatctga cagcgtttcg tatgcttctt ttacctcttt aaatttttca tctgatccgg 2137741 cttctttgtt aatatcagga tgatattttt ttgacagctt ccgataagct tttttaattt 2137801 catcctttga agcgctctta cttactccca gcacttcata gtaatcacgc ttactcatct 2137861 cgcttcactc tcccgaattt ctcacataaa ttagattgta tcattttgaa ttatgatttt 2137921 tcaattcctt ttatcccggg caagaaaaaa agtcaaagcc aagagatgcc tgactttgac 2137981 tttctaatca ttgaatcaga ttatgaaatg tgttcttttc ggtcagctcc ggaagcgggg 2138041 ctgacactaa aaagaactta ttttttgttt tggtcgtcgt ttacttcttc gtattcagcg 2138101 tcgacaacgt tgtcatccgc tttgccttca gcgtttgctc cgccttgagc ttgctgtgct 2138161 ttagcagctt cttcataaag cttcatagaa agctcttgaa cgattgtttg aagctcatct 2138221 tttttcgctt tgatctcttc aaattcgttt ttctcaatcg ctgcttttaa agcgtctttg 2138281 gcatcgttgg cttttttcac ttgttcttcg tccactttgc cttcaagatc ttttaatgtt 2138341 ttctcagttt ggaaaacaag ctgatctgct tcgttgcgga cttcgatttc ttcttttttc 2138401 ttcgcatcag cgtcagcatt ttcttccgct tcttttacca tgcgttcgat ctcttcatct 2138461 gagagacctg aagaagattt gattgtaatg ttttgttctt ttcctgtgcc taagtctttt 2138521 gctcttacgt ttacgatacc gtttttgtca atatcgaaag aaacttcgat ttgaggcacg 2138581 ccgcgcggtg ctggcgggat atcagtaagc tggaagcggc cgagtgtttt gttgtcggca 2138641 gacattgggc gctcaccttg aagaacatgg atatcaacag ctgtttggtt atcagcagca 2138701 gttgagaaca cttgagattt gcttgttggg atcgtcgtgt tgcggtcgat cagttttgta 2138761 aacacaccgc ccattgtttc gataccgaga gaaagcggtg taacgtcaag aagaacaaca 2138821 tcttttacgt cacctgtgat aacgccgccc tgaatcgcag caccaagcgc tacaacttca 2138881 tccgggttta cgcctttatg cgcttctttt ccagtttctt ttttgattgc ttcttgtacg 2138941 gcagggatac gagttgatcc gccgacaagg atgactttgt cgatttcgct tgcagaaagt 2139001 cctgcatctt gaagcgcttg acggacagga cccattgtgc gctctactaa atgagaagaa 2139061 agctcttcga atttagcgcg agttaatgta agttcaaggt gaagcggtcc tgcttctcca 2139121 gctgtgataa acggtaaaga aatttgcgta gaagatacgc cggaaagatc ttttttcgct 2139181 ttttcagctg cgtctttcaa acgctgaagc gccattttgt cttttgacaa atcaatgccg 2139241 ttttcttttt tgaattcaga caccagatga tcgatgataa cttggtcaaa atcgtcccca 2139301 cccagacggt tgtcgccggc agttgaacga acttcgaata caccgtcgcc aagctcaagg 2139361 atggaaacgt cgaatgtacc gccgccaagg tcgtatacta ggatcgtttg atcttcatct 2139421 gttttatcaa gtccgtatgc aagcgctgct gcagtcggct cgttgatgat acgttctact 2139481 tcaagacctg caattttacc agcgtctttt gttgcttgac gctcagcatc gttaaagtat 2139541 gcaggaactg tgataactgc ttttgatact gtttcgccaa gatagctttc agcgtatgat 2139601 ttaaggtgtt gaaggatgat agcagacact tcttgtggag tgtaatcctt tccttcaatt 2139661 tcaactttat aatcagtacc catatgacgt ttgatagaca taattgtgtt agggtttgta 2139721 atagattggc gtttagccac ttcccctact tgacgttcgc cgtttttaaa tgcaacaact 2139781 gatggcgttg tgcggtttcc ttcagcgtta gcaataactt taggctcgcc gccttcaagc 2139841 actgccacac atgagtttgt tgttcctaag tcgattccga taactttact cacttgaata 2139901 acctcctgct atgtaattat tgattcactt tgaccatgga agggcgaatg acgcgatcct 2139961 tcagcttata gcctttttgc atttcctcaa caacaatgtt ggagccgtag ttttcgtctt 2140021 cagcctgcat aacagcttgg tgcagattag gatcaaattc ctgccctaca gcttcgatgg 2140081 cttcgacgcc ttcttttttc aaggcttcta cgagctgacg gtggaccatt tccattccct 2140141 ggagcaaact tttcgtctgt tcattgtcgg cttcaacctg aagcgctcgt tcaaaactgt 2140201 caagagccgg cagcaaatca gtcacgatat tttgagaacg gtatttttgg gacgcttcca 2140261 tctctaaacg gctgcgtcgt ttatagtttt caaagtctgc ttgaacacgc aaaagtttgt 2140321 tttctttttc ctcaagcaaa ccttgcaatt cgttaatttg gttttgaaga agttcgcttt 2140381 catttgtttc ttcctgctgt tcatcagcgg cagcttgttc ttcaatgatt tcttgctctt 2140441 ctgtttcgtt ttgttcaacg gtttgttttt cttctgacat tgtgttcacc tccctcaaag 2140501 tgtaaggaga aggacaggtg ctgcccttcg ataaaatttg ccaaaattcc cttattcatc 2140561 atacagactt gttaatgctt ttgacaagtc cgaagtcaca tgctgaagca ggctgacaac 2140621 cctggaataa ttcatgcggg tcgggccgat aatcgcaatt gagccgatct gcttctggtc 2140681 tacggaataa gaagccgtaa tcagactgca attttccatc tcttcatagt cgttttcttt 2140741 tccgatttta atcgaaattc ccgtgtgcgg ggattgaacc agctttaaaa catcctgttc 2140801 tttctcaatt aatgaaagca gcgaccgaac tcgggtgata tcatggaact caggctggtt 2140861 cagcatattg attttcccgc caaaaaacaa cttttcaacg tgatttgtgg aatgaaaggt 2140921 tgaacgaagc gcgtcgagta tattgtcata gtttttaatg tgctgtctta ggtacatgac 2140981 aacttcttta aatatgcgct cattcagttc atccattgga acgccgctta aacggtcgtt 2141041 cagtatattt accagttttt caatatcaga cagatccatt ttggtcggaa agttaatcgt 2141101 tttgttttcc acatgccccg tattggtaac gagaatcgct accgccatat caggctgaat 2141161 cggaatgatt tgaatctgtt taaggtaatt ctcactcaac ttcggcccga gtacgatgga 2141221 tgtgtaattc gtcagatcgg acaaaatttg cgctgatttt tgaactgtct tctccagctc 2141281 gaaaattttc tctttgaaga tcgagtggat ttggtccagg tcgcttttcg tcaatttgac 2141341 gggtgacagc aaatggtcaa catagtaccg ataccctttt tctgacggaa cacgtcctga 2141401 ggatgaatgg gttttttcaa taaagcccaa ttcctccaag tcagccatct cgtttcttat 2141461 tgttgcagag ctaaatgtga tttcatcttt tttcgaaaga gttcttgatc ccaccggctg 2141521 tgccgattta ataaaatcgt tgattataac ctgaaggatc agcagctgac gatttgttaa 2141581 catcatcatc acctctgtta gcactctcaa taagcgagtg ctaattctat aacaaaagta 2141641 tcaaaccaca agaaaaatgt caattataac tcacccaaaa aagcgccaaa aacttcattg 2141701 cctaataatt tcccttgatg agtcaaataa acggcagact ccgaattgtg aatcagccct 2141761 ttttcagcga ggtcttttaa cacgcttggg aaaagtccat ccagggaacg gccgtatttt 2141821 tctgcgaatc gttttttgct gacaccggct gtttttctca aacctaaaaa catttcttcc 2141881 tcaatctgtt cttctgttgt cacttcatgt gtatctctgt acggaaaacc cttttcagct 2141941 atcaggtcaa tgtaatgctt aacaggtccg acgttcactg ttcgtgtgcc gccaatatat 2142001 ccgtgagcgc cagctccgaa accgaaatat tgttcgttgc tccaatacgt tagattgtgc 2142061 ttagattcca tgcctgcctt agcaaagttg ctgatttcat attgatgaat gccgtgagct 2142121 tccatcttgc tcatcactat ttcatacatt tcagcttcct gctcctgcgg cggaagatga 2142181 agccgccctt tttgcatcaa attataaaat accgttttcg gttctacaat aagggagtaa 2142241 acggaataat gctcagcgtc caatgataaa gcagtgttta tggaatgttc cagatgcttg 2142301 agggtttgcc ccggaagccc gaacatgaga tcaagactga tattctcaaa accgatttcc 2142361 cgcgctcttt caaaagaggt gaatacatct ttttgcttgt gcactcggcc gattttttct 2142421 aacagatcgt cttcgaacgt ttgcacacca aagctaaggc gatttacgcc tgcttctttt 2142481 aatattttta atttctctgc ggacaaatcg tccggattcg cttcaaccgc aaattccgat 2142541 aagtcgcttg agggctttag cacgcggttg atcatatcca tcagcttttt aagctgttcc 2142601 tcagacaggg aggtcggcgt gcctcctccg ataaagattg ttttgagatc aggctgcccg 2142661 gtttttgcta ttgtatttat catttcctgt tcgagtgcgt ttaaatactc gtcgactggc 2142721 tgactttgaa taaaatattt attgaaatcg cagtagtggc aaatatgctc acaaaatggg 2142781 atatggatat aagctgattt caacggattc accttcttta cagaaagaag ccgcagtaca 2142841 agactgcggc ggcttctatt gttttttcgg actgtcgtcc attttcagaa ctgccataaa 2142901 tgcttcttgc ggcacttcaa ctgagccgac ctgcttcata cggcgctttc cttctttttg 2142961 tttttcaaga agtttccgtt tacgcgagat gtcccctccg taacatttag ccaatacgtt 2143021 tttacgcatt gcttttatgg tggagcgggc cacgattttc tggccgattg cggcttgtac 2143081 cggaacttca aactgctggc gcggaatgag ttctttcagt ttttcaacga tcacttttcc 2143141 ccgttcatat gcgtaatcac gatgcacgat aaaggaaagg gcatcgattt tttcaccatt 2143201 cagcataatg tccattttca caagcttgga cggtttgtag ccgatcagtt cataatcaaa 2143261 ggacgcatag cctttagtgc ttgatttcag ctgatcaaaa aactcatata cgatttccgc 2143321 taatggcata tcataaatga tgctgacacg gtttgcgtct aaatactgca tatcaatgaa 2143381 attgccgcgt tttccttggc aaagctccat tacagcgccg acatagtcat tcggcaccat 2143441 catcgtcgct tttacgtatg gctcctcaac cctttcgatc ttttgaggat ccggcatgtt 2143501 ggacgggttg tcgacaacga ccttttcgcc gtctgtcata tacacgtcat agataacgct 2143561 tggcgctgtc gtaatcaggt cgatgttgaa ctcacgctca attcgctcct gaatgatctc 2143621 catgtgaagc atgcctaaaa atccgcagcg gaacccgaat ccaagcgctt gcgaagtttc 2143681 cgcttcatat tgaagggagg aatcattcag ctcaagcttt tcaagagctt cccttaaatc 2143741 attatacttc gctgtatcaa tcggatacaa accacagtac accatcgggt ttagcttgcg 2143801 gtatcccggc agcgcttctt ctgcaggatt ggcagcgctc gttattgtat caccgacacg 2143861 tgtgtcacca acatttttga ttgaggcagt caggaagcct acatcaccga ccgtcagttc 2143921 atttgtcgga gttgctttcg gcgtgaacac gcccacctct gttacttcga attctttgcc 2143981 ggttgccatc attttgattt tttgtcccgg ctttaccgtt ccttcaacga ctctgatata 2144041 agccacgaca ccgcggtagg cgtcataaag cgagtcgaag atcagcgctt tgagcggcgc 2144101 ctccggatct ccggtcggag ctggcacctt ttctacgatt tgttctaaaa tctcctcaat 2144161 cccgataccg gcttttgctg aagcaagcac ggcttctgat gcgtcaaggc cgataacgtc 2144221 ttctacctct tggcgcacac gttcgggctc ggcgctcgga aggtcgattt tattgatgac 2144281 cggaaggatt tcaagatcgt tgtcaagcgc taagtagaca ttggcgagcg tctgcgcttc 2144341 aatcccctgg gctgcatcca cgacaagaat cgctccctcg caggcagcaa ggcttcggga 2144401 tacttcatac gtgaagtcga cgtgtcccgg cgtatcgatt agatgaaaga tatattcttc 2144461 tccgtctttt gctttatatt taagctgaac agagtttaat ttaatggtta tgccccgctc 2144521 acgttcaaga tccatagaat cgagcaattg ttctttcatt tctcgttgag tgattgccga 2144581 cgttttttct aaaatacgat ccgctaaggt cgattttccg tggtcaatat gggcaatgat 2144641 agagaaattc cgtattctcg attgcctctc taaacgcttt tctttatctg tcacaatcta 2144701 tcactcctac tattaaacgc aaaatacact agcttagatt atatcaatag gattgtaaag 2144761 attcaatgta aaacaagaaa gagaaaagtt ccctatcata tctgggttgc ttttctcttt 2144821 cacgtactta ttgattcata tcccgtatcc attcatacat tgactgggca gtattggtta 2144881 cggtgtccga aagcgctttt ccggcttttg aaaacatatt gaatgtctcc accttttcca 2144941 gctctttttg tttttctact aaatcttttg ccgtgactgt ttctcctagg attgaggctt 2145001 ctttttcatt atcttttccg tcggtgagcg taaacgcccc cttcagtgaa gggtcatgat 2145061 agcctttcat actcagcatc ccgtggtttg cctgctgcat gccgaacaga acgcctaaaa 2145121 acatgatcgt gacaagcagt aagcactttc caaagtatgc aatcaaatca accacctatt 2145181 tcttattgtt ttttcgtctc cccgctcgct gcgttgacct tttcagcatc ccagtacatt 2145241 tcgctgaata cgtccgcggc cgcgttagcc gcacgctgca gctcttcgag attattatcc 2145301 actccgccaa actcgagcaa aagcgctcta tcggttaaat cctgattgta aacaccatta 2145361 tcgcctggcg agcctttgga aaagacacct gtgctaagtc cggggtattt tttctccatc 2145421 agtttatgaa gctcactcgc aattttatag ttttcttcga agtttttgct ttttttcccg 2145481 acgacaaagg ctaccctggc atagcttttc cctttaatcg ttgcggttgt gtcttttttg 2145541 cgccgagagt ctctgtggat gtcaatgata tattgcagat ttttgtttga agcgagggcg 2145601 tctttcacga ccggccttga ttcatcatag gacctggcat agtttaagcc ttttttattc 2145661 aattttgact gtatatcggt tttattcact gtggctccga ttccctggga ttcaagcgct 2145721 tgtccgaaca tatctcctac aagcgtgaca ttggctttag aatggcgcgc catgtcagga 2145781 tcggtctcgc cttttaatag agggagatat gattccgtat tgtgcgtgtg atagataaac 2145841 acgacctttt tatcacctgt tgtttgtttc ggcggatctt tttgcgcatt atctgattgc 2145901 gtttgctgtt tttcaatctc tgccaaattc gcttctcttt cttcctccat caccttagac 2145961 ggcggcggcg attccgcagg catattcgta taatccgttc cttgtccagc taacaaaatc 2146021 tcggtatcaa attgtgcaaa tcctggcagc tcccgaccga gaaagctccg cggatcttcg 2146081 aggttaatgc tcgtcgccag ctttaaagaa agacgagaaa gatgaaatga gctgtctgtt 2146141 tgagagaggt cagaagcgaa ataatggttt tccatctgca gcaaatgtgc aaatacgtca 2146201 cccggcaatt cttcagcaat cccataaaaa gagtcagacg acggcctaag ttccggccgg 2146261 agagacgtca gcacaccgga tagaacaaaa atcacgataa ggcttacgat aaatagaaag 2146321 atggctttta ccgctttccc tccatttacc gcaacaacaa tctgtctgtt tctgcgttta 2146381 tttctcattg aatccctcca gcgcttgtct agtaattact ctatgaacaa gctagaggaa 2146441 gtagaactgt ttagtgattg taggagcctt tgttttcttg tgacactttt tcatgaagcg 2146501 ctgtgtttaa tccgttcgct aaaacatttg ccatatcgtc gataaatgaa tcgacttcct 2146561 tcggtgtaac cattaagttg tgccctaaag gcgaaagcac ctcgtgaatg agctgccgtt 2146621 tttcatcttc ttgaagggtt ccgacaatac ctaggaacga ttggcgctgc ttttgatcgg 2146681 gaagatcgtc ttcagtgagc actttctttt tcccaaacgt catgcctgcc ggaacaagcg 2146741 atcttgatgg cctgttatcc ttcatttctc tgccaaaatg ttttaatatg tagtccaccg 2146801 tgtcgctggc aattgtcacg gcatcaacta ctgtcggaac accgatagca atcaccggaa 2146861 caccaagcgt gtctttgctt aaatcttttc gtttattccc cactccagac cccgggtgaa 2146921 tgcctgtatc cgatatttga atggttgtgt tgaccctttc caccgcccgc gccgccaacg 2146981 catcaatggc gatgacaaaa tcaggcttcg attgctcaat cacaccttta ataatgtcac 2147041 ttgtttcgat tcctgttatc cccattacac ccggtgcaaa agcactgaca ggcctgtaac 2147101 cctcctgtac gttttccggc tgaagcttaa acaagtgcct tgttaccaac agattttcta 2147161 ctgccatcgg tccaagcgca tcaggtgtca cgttccagtt gccgagccca acgatcaaac 2147221 agctcgcatc ttttgagata ttaaggtttt caagaaaagc tgagaattcc tccgcaaaga 2147281 cagcagagac cttctcctgc atttccgaat cattctccct gattccctgt gcttcaagcg 2147341 ttaaatagcg cccttctttt tttcccgaaa gctctgcgcc ttcctttgta acatcaactg 2147401 tgcggatttt aatgccgccg tgatcacgct ctttttcaat aaagccttta atttcttttg 2147461 tcggcacagc ctgctgattg gccattgctt ccttcgtttc cactgccaaa tcggtccgta 2147521 tcaaatactg attcacatcc agctcactct ttttcataca ggggcctcct tcacattaag 2147581 tacctatatt gttgccattt gctgaataaa tcatgctaaa aagagaacct tcaatgaaaa 2147641 atactttaca tttatattgc aatctaaagg tgtgtttgat agaatacaat ttgttctatt 2147701 gtgaagaaga tttaacctta agacactgtg ctacaggttg tatcttagga ggtgaaacac 2147761 atgccaaaca ttaaatcagc gattaaacgt acaaaaacaa acaacgaacg ccgcgttcat 2147821 aacgcgacaa tcaaatctgc tatgcgtact gcaatcaaac aagttgaagc ttctgttgcc 2147881 aacaacgaag ctgacaaagc gaaaactgct cttactgaag cagctaaacg tattgataaa 2147941 gcagtgaaaa caggtcttgt acacaaaaat accgcagctc gatacaaatc aagactagcg 2148001 aaaaaagtga acggactttc tgcataatat aaaaacgatc ctcaataatg gggatcgttt 2148061 ttttcatttc tttttaacag ctgtaaaagg aacagttcga gcaggagctg cttgtccttt 2148121 ttcccggttt tcatctcata gtccatgacg gcaagctgtt caataattaa acggagctcc 2148181 tcctctgaaa aaagccttgc ttgatccatc gccagcttta cccgaaatgg gtgaactttt 2148241 agattagaag cgatttgttt ttgtccgtat ccctgttccg cgaagtactt cgtctgcaga 2148301 atcagccgga actgattcga aataagcgcc ataattttga tcggttcttc attttgtttt 2148361 agcaaatcat aaaaaatttg cagactctct gttcgttttc ggttgacgat tttattgatc 2148421 agctcaaaaa tattttgttc aaggcttcta gcaacaagca tttttacatc atccagcgta 2148481 atttcttcac gatctccaat aaacgtgcag agcttttgaa tctcctgaaa aatcgatgac 2148541 agatgaccgt tcacaagcag aaccaaatgc tccgccgctt ccgtgccgat tgttttctgc 2148601 tctgtttttg caaggttgac agtaaagtct gtcgtttcct ttgcatttaa ttccttcgcc 2148661 tccatcataa acgcgtgctt ctttaacgct ttcgtcagct tttttcgctc atcaagcttt 2148721 tcatacggag caagcaggac aaagactgtg taaggcgcag gtgattgtat atatgattca 2148781 agcgcactga cgttgtgctc aattttttct tttttctttt cacctgttaa aaaatatgga 2148841 tttttcacaa tgacaagacg ccgctccccc ataaacggaa acgtttcagc atctgcaatc 2148901 gcttgatcca gcgggtcctc ttccagatca aaaacggaca gattgaaatc ctttgtctcc 2148961 tgatcaacga ccgtctgtct gatcctgctg acggtttctt gcagcagata tgtctctttt 2149021 ccgtataaac aataaaccgg atggacctct ccttttttca ggcttttcca cacatcaaat 2149081 accattgttg tacgacttcc tctctttcat catccccttc tatcctaaat tgagtttgca 2149141 aaatagtaaa gaggaagcct gactgctgct tccccattta tattaaacgc ctgttcgcaa 2149201 gcccccggga cagcttgtaa aaaggcgata atcaccagaa cagaaaacgt taccttagct 2149261 tctagatttt tcaaaacaat tccattatac ttaagtcagt caggagggat aaagttgaat 2149321 gattttgaaa aaaacgttca aagcaaacga aatgatgctg tagattcagc tgttggtttt 2149381 gttgtgtcct tcggattttt cgccttcttg tttgtcatgg caacggttat tcacctagtt 2149441 ggttcataac agcgactgcc cgggctgctg atttctcggc agtctttttt agttcgtctc 2149501 tgttatatct gatgtatcat atggaggata gacagaaaag gttccaactc tgtttttgta 2149561 tctatattgg atcgttccgt tttgatctgt tcgcagcacg cggatagaat gtctctgtaa 2149621 tagttgcaga actttttgat gaggatgatg gtaccgattg tttttcccgg ctgagataat 2149681 ggccgttttc ggctgaagct gttggatgaa ttcttcaccg gtagagcctt tgctcccatg 2149741 gtgccccacc tttaacacat ctgcttttat attcggaaac acgttcatca cctcttgttc 2149801 cccttctttc tccagatcac ccgtcaagat ccagctcata ccgcccgtct ccatccacag 2149861 aacgagagat gaattatttt tgcttgccgg atcaggtgct tccggtgaca gtacatggaa 2149921 ctgcaaatcc tttatttgca acacatcgcc tcgcttcacc tcttcaattg ccactccctc 2149981 ttccctggct gcctgcagca ctttctcatc tttaggttca gaaacgaacc ctttcggaat 2150041 cacgaggcgc tttactttat gatgcttcag cagaatctcc gcctctccga tatgatcttg 2150101 gtcagcgtgc gtcagaatta aagcgtcaag ctgcttgatt cccttagcag ttaaaaacgg 2150161 aatcagcacc ttttccccca gtgaaaacgg atgctgtttt tcgcgccaag gctctgacga 2150221 gtaagacaaa gtgccgccgg tatcaattaa gacacgaccc cgctgatgcg gagcacctac 2150281 aaacatgctg tcaccctgtc caatatctat catatccact tctccttcgg aactaagaca 2150341 cggatatata aagagcagaa acatcaccgt gcagcaaatg cctccggtta ccatcaactg 2150401 cgacaaggag cgtttttcaa tcgccataag caataggatg atcgtgactg tgaataaaaa 2150461 aagcaaaaca ggtgcaggat gtgcgatcat aatcgtgaac acatcaacat ctgcaatgtt 2150521 tgtgattaac ctattgatcc agcttatcaa taaatcaaac cagctgaaaa acaatctccc 2150581 aaacgaagcg gaaagactta atagaagaac acctgctaca gctcccggca aaatacagaa 2150641 ggtataaaat ggtaccatca acatattcat cggtacgctg atgatagaaa actgatgaaa 2150701 atgatatagg agaatcggaa gcgagcccag ctgagcgatg agtgatacaa ttgtcagctg 2150761 ccccaaggag gttttaacct gctgaaaaat agaagaggat agaattaaag aaaaactgac 2150821 ggcgaacgat agctgaaaac cggcttcaaa gagatgataa ggattgaaga gcagaaggac 2150881 gatgtacgaa aggcaaattg cagttgcaga gcggacacgc catttgacaa gacttccagc 2150941 taagtaaaca cccgacatga gagcggcgcg tagcactgaa ggagcagcgc cggtcaacat 2151001 cacatagagc ggcagaaata acagcaacag aattgacgcc ttttctctag ttataccaag 2151061 gcggatcatg atataaaaca aacctgctgt caaaatcccc acgtggagtc ctgatattgc 2151121 caagagatgg acaacaccaa gcttttgata cgcggtaagc acttcatcct ccacgtaaaa 2151181 tctgtcacca actgtaagtg cctgtacaat ccctgtcgaa tcaggaggca gaaggctgtt 2151241 tgtgaatgat atgatatgtt ttctcaagct gagcaccttg tacttgaaat tttcaggttc 2151301 gctgcagttt tggatagacg tgacagagta gttccaatga atatgctgcc gataaagata 2151361 ctcgttataa tcaaatgcac ccggcacagt tgcgtgattc ggttcttcca atgtaccagt 2151421 caactcacat gacattcctg gttctatgta taacagctgt tctttttcac cagcagactg 2151481 aatgcgatac gcagcagccc atttttcctt atcaggtgtc tcaaccatca tagacatacg 2151541 gtcgccgtca attttgggaa tagtgtcaat cactgccttg aattgatagg ttccctgccg 2151601 ataggaagag acattctgag aatctgtgac tgcatacagt acaaaaaaca atataaaaga 2151661 gaagaaacaa acaataataa gaaaagcgtg cctcgttttg attaaaatga tgaggagaaa 2151721 gaggatgaaa agaaaaatag cggggaaata agcggcggca gtaattccag ccgttgccga 2151781 agctgccgcc ataggcaata ataagcgcga attacgcatt catcacacgt agctcgtgaa 2151841 aagtgtattc gcctgttcat gtatcttttt caattcttcc tccgctaaac cggcatcagc 2151901 caatttccct attagacccg ctacaaatga aagcttttct ctgtttttca gatcaacgat 2151961 catttcatcg agttcaacct gttcaacagt tacacccgcc tgttcaaata attcctgcgc 2152021 atacggatgt gttttgtaat cctcagcata ataaaccgtt ttgataccag cttgaataat 2152081 agatttgcag cattgaatgc acggataatg cgtcacataa atctcggctc catcagtcgg 2152141 caccccaaac ttagagcatt gaagaatcgc attcatttca gcgtgaatgg ttcttgcgca 2152201 atgatcatct atcattaagc atccttcatc tgcacaatgt acgccgcccg cgattgaccc 2152261 attgtagcct cctgctatca tgcgtttgtc tctgactata gtagcgccga cagataatct 2152321 cggacatgtg ctgcgcagcg ccaataaatg gctttgagcc ataaagtatt gattccatga 2152381 aattcgttcc acgttgttcc ctccaaatgt tgtgttgcct gacctttagt ttacctatca 2152441 taatgcatga ccgtcaaatc actttactgt aatggaagac tttattttct caaatgactt 2152501 ttcacctatt cctgaaacct tagtgatatc ttcaattgtt tggaaacgac cgttttcctc 2152561 ccggtatgca ataatagctt cagctttgga tggccccacc cctgagatgc cttgtaactc 2152621 ctctaaggtt gctgtattga tattcaccag cgctcccttc cctccatcgc tttggacaga 2152681 ccctccgcca ccttgctgca ctgctgtttc ctctcccttt ttcgggatgt acaccactgt 2152741 cccgtcctgc agaatctccg ccaaatttac ttgcgcttcg tctgcttgtt cactggtccc 2152801 gcccgctttc tcaattgcct gagatactct gtcccctgtt cgcatttcat aaacgccagg 2152861 atgctgaaca gcacctttga tgtctatcac aattgtttcg tttgactcgt cgttgtttgc 2152921 ttcctgcttt accactgtat tttctgtctc tgttggtaca gcttgcttca ccggctcttt 2152981 atttttccct gtggccagaa agatcataat cgctgtgaaa acagccgcag aagccgctaa 2153041 aataattgct ttcttatgct gattcaacca attcatcgtg catgttcccc gctttcgtca 2153101 tattttattt tcataacaca tatggtttag aggataatag ctcaaaggag gggaaaccat 2153161 tgaagatagg ctttatcggc acaggaaata tgggtacgat ccttatcgaa tcatttattg 2153221 aatcaaaagc ggccgatccc tcaaacatga caatcacaaa ccgcacaatt gaaaaagcgt 2153281 tgcacataaa aaaccgctac aacagcataa acgttaccga aagtctcgaa aagctcgttt 2153341 ctgaaaacga gatgattttt atttgtgtta agccgcttga tatatatcct ttactggcaa 2153401 gagcgttacc ttatttaaga aaagatcata ttctcatttc aattacaagc cccgttcaaa 2153461 ccgaacagct cgaacaatat gtgccgtgtc aagtggcgcg agtgatccca agtattacga 2153521 acagagcgct ggcaggtgtt tctctcgtca ctttcggcac aagctgcggc gaatctgcaa 2153581 aagcgaaaat caatgagctg atgcagcata tctctcatcc gctgcaaatt gaaagtgaca 2153641 tcacgagggt tgcatcagac atcgtaagct gcggccccgc ttttatgagc tatctgattc 2153701 agcggtttat agatgcagct gtttcggaaa catcagtgtc taaacaggac gcgattttga 2153761 tgtgtaagga aatgcttgtc ggaatgggaa aactgttaga aaccgaattg tataccctgc 2153821 ctgcattaca ggaaaaggtt tgcgttaaag gcggtgtaac aggagaaggc attaaagcgc 2153881 tggaaagcgg tgtgcaggat atgtttcacc gggtatttca aaatactcat atgaagtacg 2153941 aggaggatat ttccgcagtg aaaaagcagt ttcatgtgta gacgagtatg tcatacgttc 2154001 gtctgtactg caaaagcata aaaaagcatt ttaaaaaacc atcgttttag gaaacgatgg 2154061 tttttgattt ctgcgccttg aaaaagaggc gttctgattg tgctgatggc tcggtatccg 2154121 taaaatcagc tgtcacgcga tggagctgaa agccgcagtt cttaagcatt tcttcgtatt 2154181 cttccaccgg gaacgttctt tgctcgtgtg tctcatcaaa acgatcatac gcttctccgt 2154241 tccacacaaa aaacgacata tcatgaatga cagaaagctc gtcacttccg gcaaagctct 2154301 gccaaatata gctgatatct tcgtcctggt cagcaaatgt gctatccgga aagacttccg 2154361 caattttaaa agatgaatga acatcaaaca gcaggatgcc ttcaggcttt aatacccgaa 2154421 aaacactttt aaaggtttcg atcacatcat tttttgtttt taaataattt aatgagtcac 2154481 agcatatcac aacagcgtca aattgaccgt caaagccggt aatctctctc atatcctgct 2154541 gaagaaataa aataggctgg ctactcgata ccttttgctg ggcgaaagaa agcatctctt 2154601 cgctgagatc gatgcctgta acctcgaagc ctttttcggc aagccggatg gagatttccc 2154661 ccgtgccgca tgccagatcg agaatacggc ctttttccgg gagagatgct tcaatccatt 2154721 ttgtccattg atcgtaaggc gcgtgtgaca ttagctcgtc atacacgctt gcaaagcctt 2154781 gataaatcat tgattcattc caaagtcaag atctgcgagc ggagcgtctc cccacagctt 2154841 ttcaaggttg tagtagcttc tttcatcctt gtggaagaca tggacaacta catcgcctag 2154901 atcaacgaga acccatcttg cttcatcaaa gccttccatc tttttgactt gaatgccgtt 2154961 ttcatcagct tgatccttga tttcacgggc aatcgcctgt acctgtttat ctgaatttcc 2155021 gtggcagatc agaaaataat cagcaaccag agaaatacct tccatatcca gtgctaaaat 2155081 atcctctgcc cgtttatcat cgcaagccgc agctgcgatc tttaaaatgg acttttggtt 2155141 cattcacaaa ttcctcctgt tcagctgcca gacacaagcc agttatacgt taaaaatgtg 2155201 tctggaaaaa ccggttgatt ttttttcata agaaaaacca ttgtattttt aatggactga 2155261 atcagcgctt gattcaaatc tgtctcagca agcttacgca cctcatcgac accgggaaat 2155321 gcccggtttg gctcaatgta atcggcaacg taaatgactt tttctaaaag tgtcatgccg 2155381 gggcggcctg aggtatgata cctaatggcg tcaagaatgt cttcatcttg aacccctgcc 2155441 tctctttgga ccaaataagc gccgaccgga gcgtgccaga gctccggatt atgatccaat 2155501 aaatgcgcag gcattttttc acgcgcaata atttgtttca tttcttcttt cgggcggaat 2155561 ttggcgtaat catgaaagat tgccgctatt tccgcttttt tagaatcggc tccaaaacgc 2155621 tccgcaagtt cgatcgccgt gttcatcacg ccaaccgtat ggatatatcg gtgttcggtc 2155681 aattgctgct tcacgcatgc aagtgcctcc tcacgattca tataaaccat tctcctctac 2155741 atacttcttc actttatcag ggattaagta gtcagtgggc ttcttgcttt taaaccgttc 2155801 ccttatcata gttgatgata cctcaaattc cggaacgtct gcaaagagaa gcggataagg 2155861 ggtttcaaca tgaaaaccgg ggcgctttac tccaataaat tgaatgaggt tcagcagctc 2155921 gtccagctta taccatttcg gcaaatattc aatcatatca gcgccgataa taaagaacag 2155981 ctgatcattt ggataacgct gcttcagtaa agaaacggta tcaaaggtat atgatggccc 2156041 ttctctttcc atttcaacaa gctccagctt aaaggacgga ttagattgaa ttgcaagctt 2156101 tagcatttcc acgcgatgaa agctgtcggt atagtcttcg ttctgtttat gcggcggaat 2156161 ttgattaggc ataaaccaaa tttcatcaag ccccgcctgg tacagcacct cattcgccat 2156221 taagaggtga ccattatgcg gagggtcaaa cgtgcctccg aaaattccga ttttcttcat 2156281 ttcaaccacc tttaaggaag ctcgatttgt ttattttcct ttgattcctt atataacaca 2156341 atcgtattgc cgattgtctg caccaattga gagcggcttc cttttacaag agcttccgct 2156401 acatcgtttt tatcctcttc gcaattctga agcacgctga ctttaatcag ctctctcgct 2156461 tcaagcgcct cagcaatttg tttaatcatg ttgtcgttta ctccgccttt acctacttga 2156521 aaaatcggcg ttaaatgatg cgcttttgaa cgcaaaaaac gtttttgttt acctgttaac 2156581 attctgttcc tcctaatttt cctattacaa tagatctcat tttttcaata ttaggctctt 2156641 gtccagtcca caattggaaa gacaatgctg cctgttcaac aaacatgccc acaccatcga 2156701 gtgttttcaa gcctttttgg cttgcttctt ttaaaagtgc cgtctgtatt ggattataca 2156761 cgatatcaca tacgacggca ctgctcgcgg cacgctgtaa tgaaagcggc acatcgtcca 2156821 cgttcggata catgcccaca gacgttgtat ggatgataac atcatactgc tcaagacgtt 2156881 cttctgcttc ttttatgctt aatacttctt tattgtgaaa cgagggagta gcttctgtaa 2156941 gccgctttgc tttttctaac gtccggttgc aaatgtcaaa ttttttcggg gtatttcgga 2157001 caattgttgt aaaaatggct ctcgccgctc cgccagcgcc gatcattaag aatgacagtt 2157061 cagagatggg cttgtctaat accttcatta atgacttcac gaagccttcc ccatcggtat 2157121 tgtatccgac aagcttatct ccctctcttc tgaccgtgtt tacggcaccg agcacttttg 2157181 cactctcatc aatatgatcc aaataatcca taatggaaac cttgtgcgga acagtcacat 2157241 tgattccttg tacgcctaga gctcttattc cttttaccgc atcctccaga tcattctctt 2157301 ctaccttgaa ggcatgataa tgtccgtcaa gcccgaggtc tttcaatgat gcgttatgaa 2157361 tatcaggtga catagaatgg ccaataggat ttccgataac cccgtacagc tttttcatac 2157421 acctctcccc ttttcttaaa ttaatgaacg ccgaacaaat acatgaacgc cttttggcgc 2157481 gtatgcagtt acctttttat cagcgtcatg gacagtaacc cagcctaacc cagagaaaac 2157541 gatatctgtc tttttgtctt ttatcgtaaa cgtatgggcg accaattcag gaaactcatc 2157601 catttcatct ttacccggag gtgtgagcaa ttcccctgca tgcttttcat aaagcgcgtc 2157661 tgcattttca agttttgttc tatgaatcat cagctcattc ggcatatagc aaataaaagg 2157721 agatctttcc ccagacacat aatcaaacct tgcaagtccg ccaaaataca gtgtttgctg 2157781 atcattaagc tggaatgtgc gaggcttcag ctccttttta ggagataata ttttcaggtc 2157841 ctttttattg acataatgcg ccatttgatg gttgttgata attcccggtg tatcataaag 2157901 cgatgaaccg tcatccagcg ggatttcaat cgcatcaagg gttgtgccag gaaattggga 2157961 tgttgtaata atatcttctt cacctgacac ttctttaata atccggttaa taaaggttga 2158021 ctttcctaca tttgtacatc cgacaacata gacgtctttt ccgttgcggt aatgctcaat 2158081 cgcgtcaatt acttctctga ttccctggcc gcgacccgca ctgaccaaaa atacgtcaac 2158141 cggttttaag ccaagctctt tcgcttcacg cttcatccat tggatcagac gctctctttt 2158201 cagtgactta ggcaaaatat ccgctttatt gccaactaat aagatagggt ttccccccac 2158261 caagcgctgc agcccattaa tccagctgcc gttaaaatca aaaatatcaa caatttttac 2158321 gaccagagag tccgtttctc caataccgtg aagaatgttc aaaaaatcat catcagttaa 2158381 ggagacatct tgtatttcat tatagttttt cagtctgaag caacgctggc aaatcacatt 2158441 ttctttcgta agcgatgcag gcggcgcgta ccccaaacct gttttgtcct cggtttggat 2158501 cgtaactccg cacccgatac aaacaacctt ttccatttct tactcctccc actgaatgtg 2158561 cccttttcgt ttgagagcac tcagtattct gcgttcgacc tggcggttaa agcgcgtaat 2158621 gaatccgtca gaggaagcga ctggcacgac caaaatcgta tggtagccgt ttcggtttcc 2158681 cccgagtaca tcggtcagca gctggtctcc gatgacaacg cagtcctctt ttttcagctc 2158741 catattgcgc accgctctat taaaggcttt acccatcggt tttcttgctt tatagatgaa 2158801 tgggattcca agcggttctg agaaaagttt cactcttctt tcgttattat tagagacaat 2158861 tgtcacttta atgccgtgtt ccttcatttc ttcaaaccac tcgatcaatc gcggcgtcgc 2158921 gttcggcctg tcccattcaa caagcgtatt atccaggtca gtaataattc cttttacatt 2158981 tcgttccttt aatttctcag gtgtaatatg aaaaatattt tttacaaact cgtcaggtaa 2159041 aaaaaacttt tttaacaaaa cccgcaccct tccctttttc tttctttcaa aatgattgtc 2159101 gaaaaaaatc gaacttgcgc ctaaagaaaa actgagcaaa aaaatttcga caaaaattgg 2159161 gtttcttcac caggtgtgga taaatttaca cacactatcc actcttatta catcactctt 2159221 tagacaaatt ataaacacga tactcacaag ttatccactt tttggtgtgg ataacagaac 2159281 gattgttctt atatgcattt catggtagat taaagataac ttcaacctca gatgaatgca 2159341 acttatcatt gtatgcgtta aaatcatgaa tgattccaac ttttaaggag gtgcctctcc 2159401 cattaattgg gttcctagca tgagaaaact gtctgatgaa ttactaatag aatcttattt 2159461 caaagccacc gaaatgaatt taaaccgtga ctttattgag ttaattgaaa acgaaataaa 2159521 aagaagatcg ctcggacata ttatttccgt atcttcttaa taggaatttg tctatttttt 2159581 ccgggcgtat ttcctttttt tactcagatg actgatatta tatcactttg gctgcgcgct 2159641 ttactactat tttcagcaaa aaacacccct aaaaagaggt gttttaaagg gccggttatt 2159701 atgctaacca gtatatgccg cccacaacaa ggagaacaac aactaaaaca acaataaaag 2159761 cgtatccata tgctctgcct gcgccataca tgtgaagcgc ctccttaata aggttttata 2159821 acagcctatg taggagaaat aaatcggact aggcggttgt ccggctcaac gctgcaggat 2159881 ctgccccgcg aactaattta ttaatgttca acaacagaat ttcgtctatt ggcaataaag 2159941 aatccacaaa tcattgcaag aatggccatc gcccaccaga acgttgagat cgcctgatca 2160001 tgatcgatga taatcaaacg aatgacagct gtgatgccaa tataaatgaa gtagcgaagc 2160061 ggaaaatgaa agtctgattt gaagtatttg ataatcaaag caatgaactc aaagtacatg 2160121 aagaatataa gcagttctcc aagcatctca taatagctgt ccactttgtt gaacagtgac 2160181 ttgtatacga atagcacaat gtaccaagtc tcgctgatca gaagtgcgct taaggctaac 2160241 gccagaaaga acagacagac gttgagaagc gcttgtaaca ggtaaggcac ctttttgaat 2160301 ttgttagaaa atctcatcat gttgtctcct atttcaatat attcgtggtt tttattctca 2160361 gcctacatct tggtgttcca aaatcgtagc acaatgtagt acttagaatt cttttgtata 2160421 ctgtgaaact gtccctgcat gcgggacatc attcgcgcaa tgcttctttc accgagtccg 2160481 ttgctttccg gtgttatatc tgcaagttta atcgtattgc taacatggat ctcaaatatc 2160541 tcttgatccg atacaaacgt gatactgatt ttttcttccg gatctgcgta tttcaataag 2160601 tttgacatca cattatcaaa tacacgacca agctcctcca aattcacgtt aatataggtt 2160661 tccggcagct cgcctgaaat atggacccga aaatgctcct gatgaaggat agcaatctga 2160721 tctgatatta gatcgtagat cacttctttc actgcaacgg tctccagatc ggcctcatat 2160781 tccttgttca gcaggaaata cgcaaacaga ttgtcagaca agctttttaa ttgcagtgct 2160841 ttaccataag cattggctac ataccgatct ttgctggcac ccgcttcgcc tccctctttt 2160901 ttggcaaact ccagattcat gatcagcgac gtcagcggtg tgcgcatatc gtgcgacatt 2160961 tcggtaacca ggctgcggct ctcagcttgc aattcctcga tagctttaag tttatccagg 2161021 aaagctttcc gcagatcctc aatgctcttt gcaatcatcg ctaattcatc atgccctttt 2161081 atcgtcatct cgtagtccag ttcgccccct tcaagaatat gaatctcttg atgaatcgtt 2161141 ttaaggtagc gaagactttg gcgaattccg aagagaacaa tgattaaaaa gatgagggtt 2161201 gccccgagca aatccaatgc aaaggccaga tcataatatc gggaagagta gaaaccgtcg 2161261 ataatgactc gtccttcacc atcgctaaac ttgacaggat gtgaatgatt ttgagcgtac 2161321 tgagtcagct tttcctttcc ataatccgat tcggaataaa tagaatcata ttgcagctcc 2161381 tgatccttga atatggtgag gttaatgtaa ttttcttttt tgacccactc gccaaacgct 2161441 tttctatctg atgtagacaa ctcattttct gaaacgtact tgctgaattt ttgaatgtat 2161501 cttgctgact cctcgtgata atactcttcc gaactcagat atccctcgat cagatcatct 2161561 gtgatctttt gcaacgtcag aaagatcaca ccactcacaa tcgcagcaac cattatcagc 2161621 aaagccagtt ttttggttag cgtaaattta agatgcgcca aatcgatatc ctcttcccca 2161681 ttcagttttt atataaaccg gacgtgccgg atcatcctca attttggagc gcagcttccg 2161741 tatatgcacc atcaccgtat tgttggaaca gtaaaagtaa ggctgtcccc acacactctc 2161801 atatatattt tgggcagaaa atattttgtt gcgtttgttc atcagaagtt tcaggatacg 2161861 atactccaga tctgacaact tgatttgctt ctcctctttc cacacctcat taaattcttc 2161921 gctcactctt agtttgcccc cgataagaaa tgtttcttcc tgttccttct tttcctgata 2161981 gatagtatat ctgcgtaatt gagcaatcac tctagcgtga agttcctctt ccgagaatgg 2162041 tttagtcata taatcatcgc cgccggcgag taatccctca gttttatcga gtgtactcga 2162101 tctggccgtc agaaacagaa tcgggacgtt agaggatttc ctgatgtgct gacatgtttc 2162161 aattcccgaa atgcctggca tcataatatc caaaataacc aaatcaagcg agtcattcac 2162221 aagttgcaat gctcgctttc catccttggc tcttagcacc tcgtaacctg cacgtgtaag 2162281 ggattcctcc aaaagatcac caatatcctc atcatcctct acgactaata ttcgataggc 2162341 catgtctctc tcacctcatg attcttgttg ttatttctcg tgtgtcctta ctatatatcg 2162401 ttcatagtaa taagtacgtt ataagatact acgtaaatct taacaattta tgaaagctga 2162461 tgctcgccac aaatttgtca cattttctaa aaaaaatgat gactcttcat aaattgttaa 2162521 gattcggtct ttatatttat ccattgtaag gctcaagttt ttcagatccg cactacacat 2162581 tgccgtgata aatgggaaag gagtattgat atgattgtac aaaaagaagg acgcgggcaa 2162641 ccggtgagtc tgcgggaacg ggttcatttt ctggacatcg tacgaggatt tgccttgctt 2162701 ggcattatta ttgtcaatta ttttctgatc gtagattcag taaagggatt cgaaatggcc 2162761 tccgatgacg tactgcataa gctggtttcc tggtttgccg aagggaaatt cgttacgtta 2162821 ttctccttcc tgttcggagt cgggtttatg atctttatgg atcgagccgc gcagaaggta 2162881 gagagtccca acaagctgtt tgcccgcagg ttatctatcc tgttgggatt tggcattttg 2162941 cacatcacat ttgtttgggt cggtgacata ttggcctttt acgccgtaag tggcttcctg 2163001 ttactcgcct tctataaacg cacggccaaa acggtgctta gatggattat cgcacttatc 2163061 gtgtttcaat tcctgactcc tgttttcaca atgttgtaca atgtcatcaa tactgcaggg 2163121 tcaaaaaacc cgaatttttc agagtttact ttgtttagcc acagcagcct tacctacatg 2163181 gaatccatca gcactcggtg gacagatatg gtcacgatgg ctgccggctc tttctctatg 2163241 atctattcca tgtttctcat gtttctgctg ggcgtgtact ttgttaagat ggaatttttc 2163301 aaagacatgg aagcgaaaaa gcctatatgg aagcgtatct ggatcattag cacaatcgct 2163361 tttctaataa cacaaagcag tatattacta gacatgttta atctttctga gaatatgctg 2163421 tggaaggaca tttcctctgt cttgggtcaa aatggcggct taaccggaag tatgttttat 2163481 atgagcactt ttgcaatgct gtttctatac cttcctcagc tgcgaggccc tatgatgata 2163541 ttcaccaaag tcggacggat gtcattgacc tgttatctgc ttcactctat cattggaaca 2163601 gttctgttcc tcaggtacgg attcgggctt gcggatcata ttcaatccgc cggcacgttc 2163661 atgttcagtc tggccgtgta cttcgttctt atgagcttta gtacattgtg gttgaaacgg 2163721 tttaggtacg gtccgatgga attagtatgg cgcaagctga cgtacggcaa agtaaacggg 2163781 agtcccaaag caactccgct gcattcggaa aaatctattc agaaataacc cccttgcaca 2163841 gattgcatga cttcaaatta gtgttgttga atgaagcggg cattaaacgg acagatttga 2163901 tatatggact agttattttt atatcattta ggcttctttg ggctaataaa tccaccagag 2163961 tttactcaat gtgcattgct catgatcgaa tctaaattga atcttttacg catgttcata 2164021 gtcaaaggcg cctcattcga ctatttttgt aacttttcgc aggaaaaatt cgagaatgat 2164081 gacaaatccc gcatacgaca cttaatacgg tagtgaacaa tagtaaatta gggttacatg 2164141 cagcttgttt tccaatgaaa caaagaaaaa gaatcataca aaaagacagg agaaagcttt 2164201 tgaagtattt taacgccaaa tttaccgcgg aagaaagagc gatggaatca cttttttgtg 2164261 aaaaggcctc gcagagcagc tcgaatgttt tactgaacga ctgaactcta tattttagca 2164321 actgagggag tgaacaatca tgaaaactaa aaatgaacca aaagttattc tggaactagc 2164381 aaaggaatct gatctgccag aattccaaaa aaaattacaa gaagcctttg cgatcgccgt 2164441 gattgaaacg ttcggtgatt gcgaagatgg gccgattcca tcggacaatg atgttcagga 2164501 gtctttcaat gctcccggag cagtggtata tcatattctt caggatggta agaatgtcgg 2164561 tggtgcagta gtacgtatca acagccaaac aaatcataat tcgctagatt tattctatgt 2164621 atctccagaa tatcacagcc aagggattgg tctttctgct tggaaagcca ttgaagcaca 2164681 gtatccggat actgtgcttt gggaaaccgt gacaccttat ttcgaaaagc gaaatatcaa 2164741 cttctatgtg aataagtgtg gatttcatat cgtagagttc tacaatgaac atcactctaa 2164801 tccgcatatg catcgcaatg gacgtgaaga tgacaagccc ctactgaatg atgatgactt 2164861 tttcagattt gtaaagatta tgaaaaaaaa ggactaaaca attgaacacg gcgagatgcc 2164921 gcagagagtt gctggtaact tttttatatt tcattatcag aggaaggtaa taatgatgtt 2164981 taaaaggtgt tttgatccct gtctcataaa caggggtcaa aacacctttg aatcatcggt 2165041 ttcttttctg acatatacca cgcccactag tccctcaaca tagtaaaaac atatcatgag 2165101 ttacaaaagc ttttattcaa agcatatgtt tattttattt atacttattt tcatcatttt 2165161 tcagaattct ggacacaaat cgggtaccta ttagaggcca aggaactcta catttcatta 2165221 agaaatacgt actcattgcc ctgctttaat taattttaag ccctcgcact atgccccccc 2165281 ctgaattaag tatttgatgt aactttgaaa ttaagtttat gaaaatctgt cacaaaccct 2165341 tatttcataa cacatcattt gtttcagctt ccctcgcgaa taccggatta atgctcggct 2165401 ttaagatagt caaccaatct ctccgcactg ttcttaacat cttcttttga aagatgaagt 2165461 gtcccatatt gtgtaaacgc aggaagaaaa cgcattccta tatagttagc agtgacttga 2165521 aacggtctga taagctcgct gatcgtgata ttatattctc cgcctgcttg ataatcagat 2165581 tcctgtgcgc ctaaggagat agctaagagt agttcttttc catgcaattt agttcctcca 2165641 gttccataag cccagccatg tgttaacaca tcatcttccc attgtttgag taacgcggga 2165701 ctgctgtacc aatacattgg gaactgaaaa acgatacgct catgatctaa caggagctgc 2165761 tgctcttttt ctacatcaat gataaaatta gggtattcac cgtacaggtc atgaaccgta 2165821 atgtctttct cttgctttaa acgattcatc caggttttgt tgacaacaga cgtttccaaa 2165881 ttaggatgta taacgataac taatgttttc attagactga ttatcctttc tttgccaatt 2165941 agttattatt ttttacgata atgaattgat tctaatttta aaatagcaac tttatttaca 2166001 cctattttat cctttttcat gaattcaggg caactaattg ggcaccaaaa tcaatgatga 2166061 cttaagacat tgttttgtag aaatccgata tacagaataa tccattattt agaaaatttc 2166121 taccttttcc ctcaatccga gctcgctctt catgcggatg gcctatttta aaggaataac 2166181 tgactatgtt catcagttat tcctttaaaa tacgaaagtc tacgatattt ccatatcgat 2166241 ccgcttcaat gtgacagcac ccctcaagca gctgttttaa ttttccacgt ccgcgttgta 2166301 cccttgattt tgctccggag taagaaatgc cgagcttttc actcaactct ttttgtgata 2166361 acccctggaa atcagttaac tcgagcgcct ctcgatactt ttcaggcaac cgtttgatgg 2166421 tcgatcgaat acacacagtt gcttccttgg tgaaattttc ttcctctgca ctgtcattaa 2166481 aatgtagaac atcaggcaat atttcgcttg ttttttttgt acggtaaaaa tcaataatcg 2166541 tatttctagt gatccgataa atccagctgt cgatcttttg ttcatcgatc agatttggga 2166601 gatgcacttg tattttcata aatacgattt gcaagaggtc atcaacgata gattgatcgt 2166661 taaccctatg tgaaatatat gtttttaacg gctgatgaaa ttgatcccat agatcctcta 2166721 tattcatttg aaaaaacctc ctataatttt gcgtctgctt tacatttgct tcgtcttttt 2166781 aatcgtaaca aagagcaaac aattgttgaa tcaattgtat tgcagctgtt gccaaaaata 2166841 atgataaagg agaggtttgt tgtggagtat acctatttag ggagaacagg attgcgggtg 2166901 agccgtttat gtttaggcac gatgaatttt ggagttgata cagacgaaaa gactgcgttc 2166961 cgtatcatgg atgaagcact tgataacggc attcaatttt ttgatactgc caatatttac 2167021 ggctggggca aaaacgcagg attgacagag agcatcattg gaaaatggtt tgcacaagga 2167081 ggacagcgcc gcgagaaagt tgttctggcg acaaaagtat atgaaccgat ttctgatccg 2167141 aatgacggac caaatgatat gaggggcttg tctctataca aaatcagacg tcatctggaa 2167201 ggatcactga agcggcttca gacagatcat atcgaattgt accaaatgca tcatatcgat 2167261 aggcggacac cgtgggatga gatatgggaa gcttttgaga ctcaggttcg ctccggcaaa 2167321 gtagactata ttggatccag taattttgca ggctggcatt tagttaaagc gcaagctgaa 2167381 gctgaaaaac ggcgattcat gggactcgtc actgaacagc ataagtatag tttattagaa 2167441 cgaacagctg aaatggaagt gctgccggct gcacgggatc ttggtttagg agtagtggcg 2167501 tggagtcccc ttgcaggagg gcttcttggc gggaaggcat tgaaaagcaa tgccggaact 2167561 cgtacagcaa aaagagcaga tttaattgaa aaacatcgtt tgcaactcga gaaattttca 2167621 gatttatgca aagaactagg agaaaaagaa gcaaatgtgg ctttggcatg ggtgctggca 2167681 aatccagttt taactgcgcc gatcatcgga ccacgaacgg ttgagcagct gcgtgatacg 2167741 ataaaagccg ttgaaatcag tctggataag gagattctcc gcatgttaaa tgatatcttt 2167801 cccggacctg gaggagagac acctgaggca tacgcctggt gatacattca ttactcaata 2167861 ctgacatttt tcttaaatat ttatactgaa ctatcatatt aagaaagaca agagcatgtt 2167921 tgtctcttgt cttttccaca tcgtgctgaa aatgctggct aaacatcgac aaaaatgctg 2167981 ccgcttaaaa aagaacccta aacaatagag taactggaaa gacaactggc ttgatcagct 2168041 tgggacccct ttcagctgta tttaaatcaa tcaaactaat gattcattgg cagtctaaat 2168101 attattattg tttctttaca aaatagtaat agcccctgta atgattgcta acaacgtaat 2168161 aactaatgat gtaattacag cccacttaac ggcaaacctt tgaaatgacc ccaagtccat 2168221 tttaagcatg cttactagca atactgttga cgcaaccaat ggactcatca gatgaaccgg 2168281 ctgccccatt atagaagccc ttgcaatttc tactggttct ataccatatg ctgaggcagc 2168341 ttctgcaaag ataggtacca taccaaagta atatgcatca tttgataaaa caaaagtaaa 2168401 cggaatacta gtgagtgcta caataacggg gaaaaaccct cccattgatg aggggatgat 2168461 ggatattaat gatcctgcta tggcatccac catctttgtc ccggataata taccagcaaa 2168521 tactcctgct gaaaatacca ataataccac ggttatggca ttaccagaat gctcggcgat 2168581 tcgctccttc tgcattttta cattcggata atttatagta agggcaagaa caaaaccaat 2168641 taaaaataaa actgacggat gcttagttcc aagcacaata aacaccatga tacttataac 2168701 gaggaataaa ttaagatata ttaagcgtgg ccttttcaat tgttcgctct ccaaagtagc 2168761 agccatataa gattgagagc tgtcctttgt tatatgtcta ggctctaatt gaacgatgcc 2168821 tattcgattc ctctctttcc ttcccattag aaaagccaga aatatcacac aagcaatacc 2168881 tccaagcatg gtcggaagta atggcacaaa gaaatctgaa ggatccaaac ccagcactga 2168941 aatcgctctt gtagctggtc cgccccatgg agtcattccg ctaacgatac tcaacgacag 2169001 cattgctaat gtcgccataa ccatgggatt cataccaatt cttttataca aaggtaacat 2169061 tgctgagact gttatcatat aggttgttgt accgtcccca tctaaagcga taagcattgc 2169121 caagacggca gaccctatcg ctattttcac agggtctccc tttactatag ataaaatttt 2169181 ttctattagc ggatcaaata aacctgcatc aattaaaatt ccgaaaaaaa gaatagcaaa 2169241 caatagcaat gccgctgaac ttgcaactgt ttgaattcct tctaaaatca tgtcgccaat 2169301 acccttacca aaacctccaa taagagcaaa aacaatggga gtgatggtca aggcaacaat 2169361 aggcgagact ttctttgtca ttattaatat tgtaaaaaca gttaccatcg aaaaacctaa 2169421 aatagtaagc atattacacc tccaagaatg cgctttcaaa tgacttttga ttaacatatc 2169481 ttatacggtg taataagtta aataaatatt tttttactgt gtttcaaaaa aaattctatc 2169541 ataactttaa atggttacca tttgttcacc ctttaaaaaa tcaatgaatg ctttaacgag 2169601 tttgattcct aatgattttt gatcgtacat tagccaagta tctctcatta gaggcttacc 2169661 cttagcatta tacagttcca ttgtgtacaa atgatcagat tcctgcaggc aaatttctgg 2169721 tgctatggag taaccaagac catgctttac catctctttg caagtctctt gtcgatccac 2169781 ttccattgca ataatggggg cttgttttag attcgtatgc atccaatctt ctataatcgt 2169841 ttttaaagaa gcatccgttt tatatttgat aaaaggtaaa aaaggaagtt gctctatcgt 2169901 tattggtttt tttgagatga tatgtaattt ttcccgtgtc agccgttcct ccaccccttt 2169961 ccagcgatgg cttcctctca gtataccgac ttgtacaata ccagcatcta ataatttcat 2170021 gacatctgtg ctccagcctg tttgtacact atattggaca ttaggataca tagtggaaaa 2170081 ttcccttaat aacttaggga gcttatattg agcgaaattg cttgataccc ccagccttag 2170141 atgtccttgc acctctttgc ttagattaga gatatgatct ttggtatctt gaagttcctg 2170201 tagcattctt cttgcataag caaccaagtg ttctccttcc gcagtaaagg taattccttt 2170261 atgccttttg gtgaataatt caattccgaa aatctcctca atctttttca accgataagt 2170321 gatggaaggc tgtgatgtaa ataatcgttc tgctgttttt gttacacttt gttcttcgtg 2170381 aagaattttc aataaaatcc aatctttctc atccattttc atcttccttt ctagtccttc 2170441 tttcacaatt ataaaagttt ttttatcgaa tattaagaaa acttatattt tatttttatt 2170501 tttttacctt ctacactaaa aaacataaaa aatactacct ttaagatgag gatgatgacg 2170561 atggtcaaga cgaatgtaac aatcatgaga ggcggaacaa gcaaaggcgt ttttttccac 2170621 gaatcagcca tgcctaacaa taaaaacgaa tgggagccct ttttgcttga tgtcatggga 2170681 agtcctgata aaagacaaat agatggtttg ggtggcggta attcccttac tagtaaagtg 2170741 gcaataataa agaaagcata tacttcggat attgatgttc actatacttt cggtcaagtc 2170801 agcatttcgg aagaaaaggt ggactttaag gggaactgcg gaaatatctc cgctgctgtt 2170861 ggtccatttg ctattgaaga aggacttgta aaagcgaaag aaccaatgac tgcggtaagg 2170921 atcctgaata ccaatacgaa taaaatgatc attgcggaag tagaagtgga agacggtcag 2170981 gtcaaatatg acggagatgt tacgatatct ggagtacctg gatctggatc tccaatctat 2171041 ttaaactttc atgatgccgc tggttcagtt accggtcatt tattgcctac tggaaatagt 2171101 tcggagtttt tagatacaag tcaaggccaa atagaggtgt ctattatcga ctatgcaaat 2171161 ccattagttt ttgtggaagc gagcagtatc ggcctggatg gaacggaact tgcagaagaa 2171221 tttactgatc tacagttggc tcaatttgaa gaattaagat ccattgcggc agagaaatgc 2171281 ggctttgcca gtcgattttc agctacaaag ttatcgccgg ctgtccccaa actggctata 2171341 gtagcaaaac cagagaaata taaagatagt acaggtgctt ggcattcaag cgttgagatg 2171401 gacttacaca tcaggatgat gtccatgcaa aagccacatc aagcactggc tgtcactgga 2171461 gcgatatgta caacaagagc cctttcagtg gaaggtgcaa tccctgcaag aatagcaaaa 2171521 aaccactcta caaaggttcg gctagctcat tcttctggta ttattgaaac aatggtggag 2171581 cccactggta taaagatcgt ccgtaccgca cgacgtatta tggacggaac agtttatacg 2171641 catggagact atcaaatgat gtagatggac tgtgcaaaaa gcctcccccc tttccatcgt 2171701 taatagatgg attgaatgcg ccttcttgca cagatccatt gtaatcttgc atggctttaa 2171761 aaaagcctct atattgtttt ttatgaaatc gccaaggtcc tttcatgtat ctgcctcaag 2171821 catgacataa tcattataga gaaaattgaa tactttttac tgcaaataaa aagataccaa 2171881 catcattggt atcttttaga ttgagttcat ctgcagcggt ttcttttcct cactgcttat 2171941 ttgattacaa aattaccgta ctcgtttgaa cgaacatgaa tcggtccgtt tagattatag 2172001 ttgttctcct tggcgataga gcgaagcacg tccacacggg caactgattc tctccattcg 2172061 tcacgggtgt catgattggc cggattcatc agatcgtcat agcgtacgtc caagaattta 2172121 ttcaaccact tcttctcgtc tattccgtct ttaggtgatc cgcccgcttt tttgttcgta 2172181 cgtttaatca aggcataaaa agagtcaggg tcatcaccat cgccatgctg aataaccgta 2172241 tcgtacatca cagctcttgc caatgctgtt tttagtccgg cattatccga tcgtttcatg 2172301 gcaggctgat aatacaaatg gtcatttact ttgtcttgag cggcgcgaaa ttccttatca 2172361 tttgcaagcg acttccaggc agaagcgaat cccttgagat tgcttgtatc atcgctttct 2172421 tccttggcca gacggcgcaa ttcaggcaga tactttttca gtttgttatt cggaactgcc 2172481 tttgtgtata cttccactac ttccaatgca tccccggtag ccgttgtaaa gcctgcccgt 2172541 ccgcatgtat agcctcgccc gtcatccaat cgctctacat atccatattg gatctccgtt 2172601 gtgccgtttt caaagatact tgtcagctgt tccgcccggc gcttttgatc tttattcagt 2172661 cccgccgcaa aaaccgtttc gctcatcatc agggtaaaaa acatggtgaa aacaagtaat 2172721 gagatcgctg cttttttcca aaaatctgct ttttgcatac tgattttcat ttcacttccc 2172781 ctttctaaat attgtaaata cagactcagt atacatgaag aaactgccct attgttgaaa 2172841 atacatcaat ttgtcaatat tttgaatcta aagtaatata gcttgaatct tactctattc 2172901 attgccaatc agccttagcc cctctcactg ggaaggtccc ttgattttca tactgcttca 2172961 actttcatta acaagatgcc ataaggcttt actctatttt ataatggaag tgatcatcga 2173021 aaatcgttag ggaggtgatg taatggcaag caagatgaga atgccagatt ccgcaacgtc 2173081 ccatgcaaag cctactattg ggaaggcgat actttgcatg gggtagactt tctaaaagat 2173141 cgcccaagta agcttttctg atatagtggc tttgcacctt atttgacata aaaaaataag 2173201 gagctggcag aaatggcata tgtaaaagca accgctattt tacctgaaaa gctgatatcg 2173261 gaaattcaaa agtatgttca aggaaaaaca atatatatcc ctaaacctga atcctctcat 2173321 caaaaatggg gtgcgtgttc aggaacaaga aagctgatcg atgacagaaa cgcttctatt 2173381 aaaaaagcat ttaaaaacgg caaaaccatt catcaattat ctgatgaata tcacctctct 2173441 attgaaacaa taaaaaaaat tgtctactct aaataaacaa aacggaagca ctgataaaaa 2173501 ataatcagtg ctttttatat ggcgagtttg tttcttagtt atttcctgca tatgatacca 2173561 ttggccaatt gtgtaaagtt aagggagatg agaagaaagg aaggtcctac aaatgacgat 2173621 aaacaatgga acgttgcaag tacccggcgc gaacatccac tatcaggtgc gtggctctgg 2173681 tccaatcatt cttttggtcc acggaggagg cggtgatgcc gacaagttcc atcatgttgc 2173741 caatcatctg gctaactggt acacggttgt tacttatgat cgccgcggcc attcccgcag 2173801 caatctcgcc aatcagattg agggttaccg tgtggaaaca cacagtgacg atgctcaccg 2173861 tcttctagcc aaaatcacca ataagccggc ctatgtattt ggaagcagct ccggggctgt 2173921 tatcgggctt gatctgtgca tacgccatcc cgaacaagta catgtcatga tcccacacga 2173981 accaatctta ttgcagcttc tgcatggaaa tgagctgaaa caagccgagc aattcatgga 2174041 agaccttaag aaaaatcatc gaagtgaagt cattaaatta atgtcaagat tagagacaga 2174101 cgaacaatca aaggctgtcc tgacaaagcg gcttctcggc aattcaacgt atttcactga 2174161 gtatgaaatt caaggaattc tcagctatac attagatttc gaagcattaa aaactgtgtt 2174221 tacatcttca ccgatgaaga tactcccagc tggcggaagt gcttctcggg agctttttcc 2174281 ttatcgttgc gcgaacgccc tagcggaaca attggaaaca gaatgggttg aattccccgg 2174341 aaatcatacg gggtacacaa tgtaccataa agaattttct gagaggttac acgacatgtt 2174401 agaaaaagaa aagaaacata cgtgttaagg attgattaaa attttcaaaa taggacaggt 2174461 gaaactaact atggaattgg agaagatttc acgaagcgta aaaagaactt ttcactaacg 2174521 agaacgcaat gtgagatgtt taaccaaagt gatattaggg atttcatcga aaaataggtt 2174581 tgtacattac gttctcctat tgattatttc ctatcttaat tccgtatttt ataccattag 2174641 atacaactct aaagcggctc gttattttgt cctcaacaac aaccagtgtc taacatcatg 2174701 aatctctttt gaaaatcacc acaaatgcag gtatggaaga cttcatcgca gcaaaaacca 2174761 taccaactat tgttgttggt atggttcgtc ctagataggc ccttaagaag agattctatt 2174821 gtacggagta tttagctaat tgcatttgta accgacaggg ccgtctgaac ctgtgtacac 2174881 atatgtgtca gacacatatc caatattcac gacaccccgg gaatctttcc actggatttg 2174941 gtcccagata ttactcgttc catacttccc tgtaacagtc gttccataag cgtaacaata 2175001 ataaggaaca cgggagccac tcggaatgga aagcataata ggataatttg taccaggacc 2175061 gctgcgcata ttgacaggcg caccgctgct tgttgagaca gtaaagtact gaacggcaag 2175121 tgcctgactg gaaaaaatga ataaagatgc aatcatcacg gttaacatac tcagcatttt 2175181 cagtttagtc aatgtcatcc ctctttcttc aattccttca ttttaagaaa cgatagaaca 2175241 taggctacca gctgcattta ggaacaaccg gaccgtctga gcctgtatac atatatgtat 2175301 cagagacaaa tccaggaacg atctccccgc tggcaagcgt ccgctctgtg taattccaaa 2175361 tattgctcgt tccatacttt ccagttacag ttgtaccggt tttgtagcaa tagatcggga 2175421 tgcgggttcc gctcggaatg gtcgttacaa ttccccaact tgtacctggg ccgctgcgca 2175481 tgttgacagg agcaccgctg cttgttgaaa ccgtataata ctgagccgca agtgcatggc 2175541 tagaaaaaat gaacacagat gcaatcatca ccgttagcat acttagcctc tttaacttat 2175601 tcaccttata ccctcccctt ataaatgccg tacgtttgac tttcttacat ccagttaagg 2175661 atttactttc agataccatg ccccctcccc tcccatatat ttatcaatgt accataaact 2175721 agatctttca aaagtggaat tattcctatg ttttcgacaa ttaaggatac aaaataaatg 2175781 gtagtcaggc ttgatattga tggtgtgtta catttggctc ttaatcattt gtccagtcgg 2175841 taatcacgat tgacaatcag gaaaaaggac atggatcaag cggcttcgtt tccaccaatt 2175901 aactcaatca gtgtactgct tccttgtatc cacgcttctt ctcgattcat agatactcca 2175961 cctttttcac caatcaaaaa cggacaccat acaaatcagc gtaaatgctg caagttcagt 2176021 gtccgcaacc tattatgact ttgctttctt ttaccagggc gtgtaaaaat gattaggtac 2176081 gttatcaaac gttattctat gattttgcga gtcaaaaaat cataacattt tatatatttc 2176141 aatcagatta tgatctggat ctctgaagtg agcaactcgg gcactccatt ccttgcgatc 2176201 atgcggttta ttctcacatt taactccttt ttcgtgtaaa tcgtcatacg ttttatcaac 2176261 atcttctacc ttaaactgaa gcaaaaattt tgattgagct tctccttcca aggacttttt 2176321 ttcctctcca acgatttcag ccatcgtttc tcgagataaa agctctattt tcgtttcccc 2176381 attatcaaag agtgcatatt ccatttcatt ctctaaccaa cttattggaa gtcctaatga 2176441 atctttataa aactcgacgc ttttcttaaa atcattcacc aacagtctaa tttgtaacag 2176501 cttcatatcg agtgcctcct ataaaaccat acttttactg gtcatccaat ttaatgatac 2176561 caaagaaacc tgacagcact atgtcaagtt tccatacttc acccttattt cagatttaag 2176621 tgcagtttag tccatgtcat aagaacgagc aaaaacagcg attcttaaaa caaaaaatga 2176681 taccgagtgt attttctgta tgcttcaact tcatttcggg aaatgtaacg ttgataaaag 2176741 gaggttacat caatatggat catcaaacat tggcagctca tgaggctgtt gacttacatg 2176801 aaatcgtgaa ctttaaaaca ctttgtatag cgaaatcaaa gttaatgcaa gggcttgtgt 2176861 ttgaccaaga actgaaggac ttgatggaaa aagatgtaca gcaatccatt caagacctta 2176921 ctgaattaca agcggtttat gagcgtgcct catttcaggc ccctgtccct caaagccgcc 2176981 caacgccaat catcaattga aagggaggta agcctctttg aataatgatc atttagaccc 2177041 cattaattcg ctgaatgtgc ctgaactagc agacactaca ttcgcgatgg attttcttat 2177101 acgagctaag gaaggcgtaa ggaatactgc tgtagctttg acagaaaccg cttcaccaga 2177161 tgtaagagca ctgcttcgga aacagctgat gcaaggaatt gcgatgcacc aagagattac 2177221 ggaactgatg atcagcaaaa agtggttcca tccatatgag ctgagcgaac agtataagct 2177281 ggatcagctc tctgcaaaaa acacgatcat ggtcggcaat atgaacctct ttcctgatga 2177341 aacaaatcgc aaagggatgt ttgaccggac acctgatgaa cactaacact ggaggtttta 2177401 cagcatgaag gcagtaacgt atcaaggcat taaaaatgtt gttgtcaaag atgtccccga 2177461 tccaaagatt gaaaaatccg atgacatgat tatcaaagtc accagtacag ccatttgcgg 2177521 atcagattta catttaatcc atggattcat tccgaatatg caagaagact atgtcatcgg 2177581 ccatgaaccg atgggaatcg tcgaagaagt tggttctggg gtgactaaac taaaaaaggg 2177641 agatcgggta attattccct ttaatatagc atgcggggaa tgcttttttt gtaaaaacca 2177701 gctggaaagc caatgtgatc agtctaatga caatggggaa atgggtgctt atttcggcta 2177761 ttcagggcaa actggcggtt atccaggcgg gcaagctgaa tatttaagag tgccgtttgc 2177821 gaattttacc cattttaaaa tccctgaatc ttgtgaggaa cccgatgaga aattaagcgt 2177881 gattgccgat gccatgacca ccggcttttg gagtgtggat aatgccggcg taaaaaaagg 2177941 cgatacagtt atcgttctcg gctgcggacc agtcggcctg tttgctcaaa agttttgttg 2178001 gctaaaaggc gcaaaacgcg tcatagcagt tgactatgta aactatcgct tacagcatgc 2178061 gaaacgtaca aacaaagtag aaatcgttaa ttttgaagac catgagaata cagggaatta 2178121 tttaaaggaa atcacgaaag gcggagcgga tgtagtcatt gacgctgttg ggatggatgg 2178181 taaaatgagc gatctcgagt tccttgccag cggcttaaag cttcatggcg gaacgatgag 2178241 tgcattggtc attgcttccc aagctgttcg caaaggagga accatacaaa ttacaggtgt 2178301 gtatggaggc agatataacg gttttccgtt aggagatatt atgcagcgaa acgtcaatat 2178361 acgctctgga caggctccag tgatccacta tatgccgtac atgtttgaac tagtatcgac 2178421 aggcaaaatt gatccgggag atgttgtcag ccatgtcctg ccgcttagtg aagccaagca 2178481 tggctatgac atttttgatt caaaaatgga tgattgtatc aaagttgtgt taaagcctta 2178541 aaaaacggag gttacagaaa tggaatacgc cttacacgaa gtgcttgagg ttcaggaaat 2178601 gactgcattt aagacacttt gtttgacgaa atctaaaaca atgaaagcac tggtatctga 2178661 tccgaagctg aaagaaatca tgcagcaaga tgttgatatc accacacgcc agttgcagga 2178721 atttgcctct attttatcta atgcaaagca agaatgagga gatgaataaa tcatgaatcc 2178781 tatcatagaa tatctgactg gcatgaatgt tctaacagac caaatcattg ctatggactt 2178841 attaatttca gcaaagaacg gagtcagaaa ttatgcgatg gcagccactg aagccggaac 2178901 gcctgaagta aaagaggtcc ttatccgcca tttggaagaa gcactcgata tgcacgaaca 2178961 actctcaagc tatatgatgg aaaaaggctg gtaccatcct tggaaccctg acgaacaagt 2179021 caagctgaat ttaaaaaata ttgatacagc cattcaattg ccaacccttt aacatacaat 2179081 gactgatttg ctgaggaaca gtattgattg gccacaactg ttcctcagct tcaaaatgag 2179141 cactgtttgt tcgggtccta tgaccgtaaa tagattaacc gcttttctcc atctgatctc 2179201 cgataatgtt tgcaaattct ccaatccaaa taaggaatcg taaccacctc tttttatgcg 2179261 atctcttgat ggagaaaaca ggccagaaac aaaatccttc gtttttgacc tgccctcttc 2179321 acacgcaaag aatgctacct tctttgctcc actgatccgt gaagactttc cgttttaggc 2179381 ctgcttttga gctttgcctc attttcacgc aatttcccat cataatcttt aatttttgtg 2179441 tctaatctct taattgtttc atcaatttct ttccgcttct ctatcagccg ctgtcgttcg 2179501 tcagccagga tattttttcg agcttctacc gtacggtcac cttcggtaaa taatgttgta 2179561 tattcaatta gcgcttctat cgatagtccc gcatttcgca tgcatttaat gaattcaatc 2179621 catttgatat cttcttcatc atagtcgcga atgccgctgt cttttcgttt tacaggcggg 2179681 attaatccta cacgttcgta atatcggagt gttgcggctg tcaggccaaa ctgctttgcc 2179741 acctgagcaa tattcatgat cttcacctct ctatcctgta tgttgtgaag gtaacactta 2179801 aagttaactt taagtcaagc tcaaaacaag tggttagctg ctgaatctgg gtttatatat 2179861 tcgggacttg ccttaaagca cactttaaac tctatacttc tccatgcact aaaaacagtg 2179921 tagttggagg gattgctgaa tggcaaataa acacactgcc ggaagagaac aattaggaga 2179981 atttgcgcca aagtttgctg aacttcatga tgatgttcta ttcggtgaca tttgggcaag 2180041 agaagaagaa ctttcatccc gggatcgcag catgattaca gtttctgcat taattactga 2180101 ctgtttctca gcttataaat caggttcatt ttaaatggtt tttttaaaaa acccttgcct 2180161 taaagcagac tttaaggttt atcgttatgt tgaagacacc ataaaacata aataagtgca 2180221 tgtttttatt tacaacactt atgatgaaga aaggataggt tcgtatgtgt aatcaacatc 2180281 aaacccgtgt attaagcgtg tcacatgcaa aagccaaatt tgaacaaacg acgattgagc 2180341 gaagaggatt acggccgcac gatgtcttaa tcgatattaa attcagcggc atttgccatt 2180401 cagacattca tagcgctttt gatgaatggg gcggtggcat cttcccaatg gtgcctggac 2180461 atgaaatagc cggtgttgta acagccgttg gaacaaaagt caccaagttg gctgtcgggg 2180521 accgcgttgg tgtcggctgt tttgttgact cttgcggaga atgcgaatac tgtctcaacg 2180581 cagaggaaca attctgcacg aagggtgttg ttcaaacgta taactcagta gactacgacg 2180641 gaaaccccac ttatggcggg tacagccaaa aaatcgttgt cactgacaga tttgttgttc 2180701 gcataccaga tcgtttggaa atggatgttg ccagtccgct gttgtgtgca ggtatcacaa 2180761 cgtattcccc gctgaaacac tggaatgttg gccctggtaa aaaggttgcg attgtaggcg 2180821 taggtggcct tggacatttg gcaattcaat ttgcacatgc gatgggtgca gaagtaaccg 2180881 tcctgagccg ttccatgaat aagaaagagg aagctctgga actcggtgca aatcattact 2180941 ttgcaacaag tgacccagcc acattcactg cattggccgg gcgttttgac gtgatcttaa 2181001 atacggtatc ggcaaatctc gatgtagatg cctatttatc aatgcttcgt atagacggga 2181061 cacttgtaag cgttggagct cctgccaagc cggacacata cagtgtgttt tccctaatca 2181121 tggggcgccg cagcattgca ggttctctag tcggcggaat tcaagaaact caagagatgc 2181181 tggatttcgc agctgagcat ggcatcgaac ctaaaatcga agtcatcgga gctgaccaag 2181241 tggacgaggc atacgaacgt atcctccgaa gcgatgtccg ttatcgattt gtgattgata 2181301 tttccacatt gtaataggtt agtccttata tgggctgccg cttttattga aactcacgaa 2181361 aaatgatctc tttaagcaaa tattttgaag gccggtcaat cttcctgtta ttctatgaat 2181421 agagagttat taggagggtt ttttatgagc aaaaaaattg cagttcttgt tacagaccaa 2181481 ttcgaagaca tcgaatatac aagtccggta aaagcatacg aagaagctgg ctacagtgtt 2181541 gtggctatcg atttggaagc cggcaaagaa gttaccggta agcatggcga gaaagtaaag 2181601 attgacaaag ccatctctga tgtggatgca agtgactttg atgcactttt aattcctggg 2181661 ggattctctc cggatttgct tcgtgcagat gaccgtccgg gtgaattcgc aaaagcattt 2181721 gtcgaaaaca aaaaacctgt tttcgcaatt tgccacggcc cgcaagtact gattgatacg 2181781 gatcttctaa aaggcaaaga tatcacaggc taccgcagca tccgcaaaga tttaatcaat 2181841 gccggtgcaa actacaaaga tgcagaagta gtcgtcagcc acaacattgt cacaagcaga 2181901 acacctgatg atttggaagc atttaaccgc gaatctttaa acttgttaaa ataacaagaa 2181961 ggcacagact gttcgggtct gtgccttttt taaaattaag actccttcgt tacattctga 2182021 aagacagcag tcgcgtccca cacattcaag ccaaattggc cttctgaaaa tacggaatca 2182081 tgtgcatcaa tcacaagacg atcatctaaa tagattttaa agcgatcgcc ctcggcctct 2182141 gttttcagat gatacttttt attaacgtct atcggtgttt tgtattcagc aatgacagaa 2182201 gcagcaccgt tctcaaattt aaagaatttc actaggtcat gcttcgcatc cacattggca 2182261 aggtaaccgt ttttggcatc tttgtcagag cgaaacatta gtgctcctgc ccctcttccg 2182321 tttccatcct taatggtgat atcagattca taagtgaagt ctgacccgga tgctgaagac 2182381 aagataaagg aatcgccgtc cgacctccct tgtttcccct caattgtgtc tgcccacgtg 2182441 ccatttacag tcgtccagcc agtcatattg gacataaaag gtgtcgttcc ccataccttt 2182501 tttaaagggt gtatcgttaa agattttacc tttacaccgc catttgcagc atataattca 2182561 agccctttgc ttgatcggtc tgggagaata atatccgtta tgacctgctt tccgtcattc 2182621 ccaaatactt caaccgagga gcggtcaaca aaaatgcgca acttaacctt cccatttacc 2182681 ggcttcaacg gggctgtttc ttttccggtg ttaaaggccg gattaaaggt gtcgttgcct 2182741 gactcgctcc ggtcaacgaa caatttggcg ttccttcggt catagccgac cttcgtaaat 2182801 tgattttcac ctgttcggac cttaaaacca aattcagcag ctgaaccagg gcttacttta 2182861 aattctgcat ttatttcata ggcatctcca gattgccccg ctaacacatt atgacttgca 2182921 ggcgatatgg tcagattctt ccacttctta gaggttccgc gaatggtttc cagctctttc 2182981 accggtgttt ggaccactct aaccccttcg gtaaacgctt tcaattttaa ctctcttgga 2183041 atggacgttg cacttctcca tggggatgtc ggaacatcat tcgcatattg ccaattgctc 2183101 atccacccta accatagccg gcggctgtct gtggatggaa tatcagacca ggatacagcc 2183161 gcataaaagt ctctgccgta atccgtccag agaactttgt ttggcgggtt ttcattttta 2183221 aaatgagttc catcaaagtc ccctacaaaa tattgcatgc ctgatcctcc cgagaccgct 2183281 ccgtttccga cactgacctg catgacccat ttcttttgat tcggattgcc gtctaccgga 2183341 agctcaaata aatccgggca ttcccatact cccccgtggc ttccttgatc ctgtccaaat 2183401 tcacttgcat acgtccactg cttcagattt tttgatgtat aaatgaggat tcggtcaccg 2183461 gccgcaagca ccatcaccca ctttttttct ttctcatacc aaaagacttt tggatcgcga 2183521 aaatcttttt tacccgggtt tggaatgaca gggttgccag cgtacttcgt ccatgttctt 2183581 cctttgtcgt tgctataggc aatactttgc acttgatggc cttcccgatc ctgtgtataa 2183641 atggccacaa gcggcttctc tttgcctgtt tgaaaaccgc ttgtgttatt tttatctaca 2183701 actgcgcttc cagaaaagat cgtgcctttt tcatccggat acagcgcaac aggaaggtgt 2183761 tcccatgtaa ccaaatcttt gctgacggca tgcccccaat gcatgggccc ccactgaagc 2183821 ccgtatggat ggtattgata gaacaagtga tattccccag cataatatac cattccgttt 2183881 gggtcattca tccagtttgc ctccggtgtg aagtgatatt gaggacggta atcctcatca 2183941 tagtagcttg aatcggctgc atctgccgaa aatgccatag tcaacagcag ggtgaacatg 2184001 atcatgactt gaatcagtct ctttttcatt tgttccttcg ctcctctctt catgtttgaa 2184061 cactttcaaa agagactgct gcgcaagctg gtccgtttct ggcaattctc ctctgtttca 2184121 ctgttatccg aatgatttat atatgaaaag actgctgcag tttctctctc tttccttcac 2184181 acaccttatg ctaagaatcc agcccaatac ccgagaatcc cgatgacaaa gatgccgcaa 2184241 ataatgagaa gtggattcac ccctttgcga agcatccatg ccaccaataa cgttaatccg 2184301 agaggcagcg cccccggcat aatgctatct agcacgtttt gtaccgtttg aacatctact 2184361 tttccgcttt catccttaat cctggataca acgattggaa tgttgatggt ggtccatttg 2184421 gacacgagag cccccataac aaataacccg agaatcgaag cgccctctgt aagcttttga 2184481 atgcgattcc ccgctaaatc ctgaagaatc tccattcctt tcacatagcc atactttaat 2184541 ccgtaatatt ttgtgcttaa tcttatggca ttcagcaaga aaaagaatag caaaggaccg 2184601 gcaatgtttc ctcctaaagc aagggaggct cctagcgcag ctaagacagg acgaatcgtt 2184661 ccccaaaaaa ttggatcgcc tacgcccgct attggtccca tcaaaccgat tttcattccg 2184721 cttatcgctt ttccgtcaat tcctttattg ttcgccattt cttcttccat ggctgccgtc 2184781 acgccaaata taggcgctgt cagccacgga tgtgtattaa accattccaa atgccgctgt 2184841 aaggcttcgt ttcttttcgc tccgggaccg tacaattttt tgatcgccgg tatcatgaca 2184901 taacaatatc ccattgcctg cacacgttcg aagttaaagg aaccgagtaa aaaatttgaa 2184961 cgaataaaca tgctgaaaat ttctttcttc gttaatcgtt tttctttctc cattttttct 2185021 tccccctcat cgtttaggca tcaagatcat catcatcgtc atcataaaca gcaacactgc 2185081 cactgtctga tgcggccgcg actgctccgt gagcgctttg tttttgcatc acctgctggt 2185141 ataaaagcgc cagacagaga ccaagggctc caaatcccac taagttaaaa tcggtaaacg 2185201 ccgctaataa gaaaccaata tagaaaaatg gctttaaata aggaatattc atcatattga 2185261 tcaccatggc atacccgaca accacaataa tgcctccgcc tatttgcagt ccttttgtaa 2185321 tgacatcagg aatatttccc aggaacgcct gaacagcgct gacactaatt aaagcaacaa 2185381 tcaatgtagg aatcatgacg cgcaaagctt gaaacaccat cgcggtaata tgcataattt 2185441 caattccttt tatatttccc gcttttgcat attgatcagc gcggtggatg aaaaagacag 2185501 tgatcgtccg aacaaaaatc gtcagcgcct gacccgcagc tgctaaagca acagcgacag 2185561 caatcccttc gccaattcct tgatcagcgg taataactaa aatggttgag atgacagagg 2185621 cgatcgctgt atcaggtgcc atggcaagcc cgacgttcat ccagccgagc gccatcagct 2185681 ccagtgtgcc tccaagaata attcccgttt ttaagtcccc gagcaccaag ccaaccaacg 2185741 tacaggccac tagcggccgg tgtgtctgcc cttcatccaa tacacttgcg attccggtga 2185801 ttgctgcaat gattaacaac aaaataattt gtaatgaaga catattctca tccccttgat 2185861 tattttgtta cgttccgtaa aatctgtaca aaatcctcac tggcatctga aggcagctgc 2185921 ctcaattcca gtttcacgcc cttgtcactt aatgtttcaa atgcctttat atcttgttct 2185981 gtgacactga ctgattttgt gatttgcctg cgatgatttt caaaacgcat tcccccgacg 2186041 tttacggttt tgatcggtac acctgcttct ataagagata caatatcgga cggattttca 2186101 aacaagagca ttgccgttac cccttcgtag cgcggactat gaaatgcttt tgccatttta 2186161 gaaaccgaga cggcactcgc ctttacattt gaaggcgcaa cagaaaggat cagcgttttt 2186221 ctcatttcgt cctgagcaat atcgtcggag acaacgatga ttcggtcggc tgcatggact 2186281 tttatccacc ttgtcaggat ttggccgtga ataaagcggt catcaattct tgctaacaca 2186341 atgttcatca taattcatcc tctcttgtat cttgattggc tgtttttact ttttctaaat 2186401 gttcactgca cacttgaaag ctttgctgac tcattgcttt taagttgttc agcaaatctt 2186461 tgagagccag atgttctctc aggcttaata cctccagcag aatcggcagg tttacgccgg 2186521 cagccatatc cattctttga tcctcagcaa taaaggaagc tgccgcgtta tatggcgtcc 2186581 ctccaaaaat atcgactaaa aaaagcactt catgttcttc cgggatatcc ttgagcgcct 2186641 gatgatattt ttcttgcagc gtttgtattc cttccccttt gaaaaacggc actgcaatca 2186701 ggttattttc ttcaccgaat atcatccctg aagactcttt taatgctatg ggaaaatctc 2186761 catgaccgct gataataact gaaatcatat ctattgctcc tttcctgttt tgtacatcca 2186821 tatataatgc aaggatcgtg ccaacacagt tgtgttaagc gttttcattg ttatttcagc 2186881 caatagcaat ttgttgttga aacacttaaa acgaaaaaaa taaacctgta ttaaaatggt 2186941 gttccattta atacaggttc atatgaaaaa actgttttta aaacagctgg ccatgcactt 2187001 cttcagcaaa tatggcggct ataaataatt tttcatcatc acttatgcga agtccgagct 2187061 tttcttcata aggggctaat gttcgctctg tcacgtacac catttccttc agctgatcat 2187121 tgatctcttc ttcctctgag aaagcgatcg gattctgctt aattaccctt tcaaaggcga 2187181 aagccgtgtg cataatgact ttgatcaaaa ccgcattatt gaaaatgacc cccagctcat 2187241 cctgaacggt ttgcagccac tccaataaca tgtcgatcac atggtgggga ttcaagaaga 2187301 caaggtattt tttcaggcta tcctcgcaaa gctccctgac aataatattt gcttcgttca 2187361 atccattgct caaggagatg cttccttttg taatcgcctg ttgaatcagc ttctctccct 2187421 ccccttcaat taacacttct aaagatacat gcggagcatt gattttaggg tctttcgttc 2187481 cgactgtcgc aaggatttca tactcttttt cgatttcttt tatgctgttg gccagcttaa 2187541 tcgatgatac ggtcaatatg tgaatggggg tatcggaggc cttgtttacg atcgtggtta 2187601 gaatgtcttc cagctttttg gccgttccgc tacccgtcgt gcagatggat accaatgcct 2187661 tctttttgcc ggatgccgct ggctgacgct cccacaactc gataaaatcc ttcgtgaccg 2187721 attgatagat cgcatgcaaa tttaaattca aatagttgac ctttctgaca gcatccagca 2187781 ccattgaagt cgtaacattg ctgatcgttt taatagaaat gcctgtcttt tcctccagcc 2187841 tgctttccag cattgcaagc gaccccatat ctaccagcat taaaacacct tcaccttcat 2187901 caacctgttt cattttttct gctacgcatt caagaatgtc cgaaggtgaa acagtaagcg 2187961 gcatgtcaac tgctgcaatc ggcgtactcc ctagcagttc tgtcgcgact tcaaccattg 2188021 aactcgccgt gctgtttcca tgagctgcca cgataatacc gactcttttg ttctccttta 2188081 acgatttgat ggaatgaatt aacatcgtta agtagatgac ttctatttca ggaatagcca 2188141 ctttaaaata ttcctgaatt ttatctttaa aaatcatcgc cacccgatat tctttcacat 2188201 gggtatcacg aatttcatct gtctcctgtg tattcaaaac atcaatttgc tttcctcgct 2188261 ttaaaaatgc gtcaatatgc atactcaaga aataaataaa cttacggtca aatgtgcaat 2188321 ccagctcatg ttcagctatt tcttttaact gttttgtcat ttgaatcaca tcgtcttcaa 2188381 cgaatgtcag caggttgtct ttttgaaaag cttgatgatg aaaaaaactt ctgacatgca 2188441 aatggacatc agtcaagatg tactggttaa tatccttttt ggataaacct tctttcataa 2188501 gcgttttcac tttttcctca atcaaatgat ataagttaaa tgagaggtct tcgtcaattt 2188561 ttgttgtttc atcttctaca atcggagaga taatcgttgt aatattgaca tattcagaaa 2188621 tggctttgct tctttgcatg tttttgctgc tggacatcca ttcttgcttg atttcatcag 2188681 gcagatcgcg aacagtcagt tcaataactt catttctgtc aaggttatgc aaaaatccgt 2188741 gtgcgcaaac taactgaaca tttgatttca gctgtccgac attcccaaat ttcgcagagt 2188801 gaataagcgc attatagaca tcgatatgca cactcagatt cttcttaatt cgctctgctt 2188861 ctttccctaa taaaaacgtc gtcagatcca ctctttcatt aagcgatcgt tcttcaagcg 2188921 aaggaatatg aatggtcatt gggattcttc gcaaaaacgt tttcaatagt gcagaactcg 2188981 gattttctgt agtcgcacaa ataaacaata cgttcgatgt tcgtttatgt tcagattctc 2189041 caagcctgtt ataagaaccg ctgtcaataa aataaaacag catttcttgt ccctcgggag 2189101 ggagacggtg gatttcatcc ataaaaagaa tgcccccatt ggcctgttcg actaaacccg 2189161 ccttatcctc ggcagcacct gtaaatgaac cttttttgtg tccgaataat tgagaaagca 2189221 ataattgagg gttgttgtag tagtctgcac agttaaatgt aataaatggt gcgccggcct 2189281 tcaatatgtc agagtaaatg gcaaactggt aaattcggtt cgcaaaaagg gatttaccgg 2189341 aaccagtcgg ccctaggagg agcatatgca gaccgttcgg cggataaaag acagctgctt 2189401 ttgcctggga gatcgctttc ttcaaactcc cttttgcccc tatcataagc tctaggggat 2189461 tcgtggaaat gtgttgatga ttttgctttg aatttccgga aaacgcctga aggtctttca 2189521 cttccatcat ctctgtatcc catttcttgt tgaataattt ttctgctatc tcgactggga 2189581 tgtatcttac aggaaatgtt ttaattttga tgaccttttt ggaccggacg agattgttca 2189641 attcaaagct gacattggac cgctccattt tcagctgctc ggcaatctcc tttgctgaat 2189701 tcccttgtat ttttaaaaga tgatctaagg ttgaatcatg aaaattatgc ttgagctgat 2189761 ggtatatttt atctattctt ctcacgtcta tcatcctttg tccttattag ataagccatt 2189821 aacaagaata tttcgaaact ttatagtccg cgttgagatt tacacgttta aaaaggtctc 2189881 tatagcagat tgacaaagct ggcttttatg cgtatatgtt tacatgttga atcatttgca 2189941 cctcatatta gtatgataga tgctcagttc tggagggcca gtccccttca aaagtaataa 2190001 tcagtaaaca gtttatcatt ctcggggaat gtaatgatgt caaaataatc aatgacaaaa 2190061 aatgaatctt atagatcatg acaaattacc caaatataac cccttaagtt cgttcacaac 2190121 taaaaagacg gacactctat gtgaccgcca cagtattaca atttgcaaaa cttcgtcatt 2190181 tttgcaatcc acattggagg ttaaggaatc tgtaagctta aaaactttat ctccgatcct 2190241 atcgatttga tccccctgcc ggcctcaatc atagtgggta tgcaattata caaatcgtta 2190301 ccgattaaaa ctagcctgtc agattgtcca aatgactttc ctgttttact ctgctattca 2190361 ggtagaatca cgagtgaaaa atagagccac aagacatgta acagcactta aaatagtttt 2190421 aaaatttaaa aataaaagta tctattcttt taaatgttat aatatccgat aaaactttac 2190481 tcatcttttt attactggag gaaaataaaa ttgataggca attctagcaa agacaatttt 2190541 ggccagcaac agaaattgtc tagaggcctt aaaaacaggc atatacaatt aatggcgatt 2190601 ggaggtgcaa tcggtacagg tttattttta ggttcaggta aatccatcca ttttgcagga 2190661 ccatccattt tatttgctta cttgatcacc ggcgtatttt gctttttcat tatgcgttcg 2190721 ctcggagaac tgctcttatc aaatgcggga taccactctt ttgttgattt tgtaagggac 2190781 tatttaggaa acatggcagc atttatcact gggtggacct actggttctg ttggatttcc 2190841 ctcgcgatgg ctgatttaac ggcggtcggc atttatacgc aatattggct tcccgatgtg 2190901 cctcaatggc tgccgggtct tcttgcgctt attatcctgc tgatcatgaa ccttgccacc 2190961 gttaaacttt tcggagaatt agaattttgg tttgcattga tcaaagtcat tgccatactg 2191021 gctctgatcg taactggtat tctcctgatt gcgaaaggtt tttccgcagc ttccggccct 2191081 gccagcctca acaacctttg gagccacggc ggcatgttcc caaatggatg gcatgggttt 2191141 atcctatctt tccaaatggt cgtcttcgct ttcgtgggta ttgaacttgt tggactgaca 2191201 gcaggtgaaa cagaaaatcc ccaaaaagtg atccctaaag ccatcaatca aattcctgtc 2191261 cggattttac ttttttatgt tggcgcactt ttcgtgatta tgtgtatcta tccttggaat 2191321 gtgttgaatc caaacgaaag cccatttgtt caggtcttct ctgcagtagg catcgttgtg 2191381 gctgccagtt tgatcaattt tgttgtatta acatcagccg catcagctgc aaatagcgct 2191441 ttattcagca caagccgaat ggtctattca cttgcaaagg atcatcacgc acctggacta 2191501 ttaaagaaat taacttcttc taacgtgcca agcaatgcgc tgttcttttc atccatcgcc 2191561 attctgattg gcgttagtct gaattattta atgcccgagc aagtcttcac gctgattaca 2191621 agtgtttcaa caatatgctt catttttatt tggggcatca cggtgatttg ccatttgaaa 2191681 tatcgaaaaa caaggcagca tgaagcgaaa gcaaacaaat ttaaaatgcc tttttaccca 2191741 ttatccaact atttaacact tgcatttctc gcgttcattc ttgtcatatt ggcactggcg 2191801 aatgatacac gtattgcttt gtttgtcacc ccggtctggt ttgttttatt gattattttg 2191861 tataaggtgc aaacccgcag aggacataag gtgaaataaa aaaaagacaa gggatactca 2191921 ctcccttgtc tttttatatg tgtcaaacac taaattaaac tttggtttca aatttcattc 2191981 acttcattta agtgttaact caaaccagtt ttgatgccga aacctactaa tattattccg 2192041 gtaatttttt gaaacacttt ctggaacttc gagtttttca tccatttttt tgcgtaatca 2192101 ataatataaa caagaaacag gaaccacaac accgctaata aggttaggat tgaagctaaa 2192161 atgatgagct gctggtttat atttccgttc aaattgataa attggggcat gattgtaaca 2192221 tacaccaaaa cagttttagg attgagaatg ttactgagtg atccctgcat aaaggaagtt 2192281 ttataataac gtttcggaga acttgccata ttttttgctt gggattgcat gtcatctaac 2192341 gaaaacatac ttttagcaaa aaaacttttt acacctaaat aaattaagta tgccgctccc 2192401 aaatatttga tcgttgtgaa aagaatcact gactttgcga ttaccactga taatcctaaa 2192461 atggcaatca ccgtccaaaa ggaaagtcct gtcgccaatc cgagaatgtt ataacggccg 2192521 gctttcggac catacctaag cgtatttttc atcacaagca tcgtatctgc ccccggtatg 2192581 ataaccatca tggcagcgat cggtatgtat gcgagtaagc tgtgcattgt tctctccccc 2192641 tttaaaaatc ccctcaatca tatagtgact acaaaagtaa ctacttataa aagtgtatca 2192701 atgcgtttgg aataaatcaa tatgatttgt taaaatagcg attactaagg cagcgattgc 2192761 tctttatatt ggaggatata tgaaagaaaa tatgttagac attttaaaaa acctcaattt 2192821 tacagaatat gaatcgaaag cgtatttagc attattgcaa gaatcacctt taacaggcta 2192881 tgccgttgcc aaaaaatccg gagtgccccg ttctaaaatt tatgaagtat tggaaagtct 2192941 tgtcataagg ggagatgttt ttgtcagtca tggaaatacg cctcagtatg ttccagtccc 2193001 cgcaaaagaa ctgattaaaa accgccggct caaagcggaa gagcattttg atcaggctga 2193061 gaaatatttt gaaaagttcg agcagaccgc aaatgaccgg gaaaacatct ggaatatcac 2193121 cggccgcagt gaaattcttg aaaaggtgaa ggcttgtatc ttatctgcca aaaaaagaat 2193181 cctcttagaa atatggaaag aggattttaa ggagatagaa gcagagctca aacaggcggc 2193241 agaacaaggc gttattgtca ccattattgc gtacggagac atcgtatctg attttgccaa 2193301 tgtttacctt catgatatga gcagtgaaat tacagaagag tatgacggac ggtggcttgt 2193361 ctatagcgga gatgattcag aagtagtagc gggcattgtc tcacttggca acgacagccg 2193421 tgctgcatgg acgatgcatg tagggttagt catgcctatt actgaagtga tcattcatga 2193481 tctgtacctc atggaaattc tgaaaaagca tagagagctt ttagaagaga gcttcgggaa 2193541 aaatctcatc cagttgcgcc gtaaattttc tattcactca gatttcaaaa aacattattt 2193601 ggaataatgt ttgtcatctc ttaccccaaa aacaaggctt gtacaaaaca agccttgttt 2193661 ttttatgcat aaacccccca tgctgattta cttctctctt ttaaaaaatg tgattctgcg 2193721 caaactattt ttcagcctgc cgcgtctatc ctaggtaaca gcctacgata tacgtatatt 2193781 caaaaaggag ccctttattg caatgaagaa aaaacaaaca acaaaagcgt tgcttgtcac 2193841 atgcataact gaccataagc aagatttcta caggttggct ttcagttatg tgaaaaatca 2193901 agatgacgca ttagatattg ttcaggaatc tataaaaaaa gcgctgagct cagttgaaac 2193961 ggtcaggaac cctgagacga taaaaagctg gttttataaa attttagtac ggacagccat 2194021 tgactttttg cgcaaacaaa aaaagataag agtgatggac gacgaaacga tagaattttt 2194081 aagcaaagga aaggaagacc attacaagga tactgatctc catgaagcgc ttgacgaatt 2194141 gccgtaccgc tataaaacca ttattatttt acgttttttt gaagacctca aattagaaga 2194201 aattgcggaa attacaggag aaaacacgaa taccgtcaaa acgcgcctat acagagcatt 2194261 gaagctgatg cgcattcagt tgacgaagga ggatctttct taatggataa gagattacag 2194321 caattaagag aagaatataa aaatgttcag attcctaaag aattggatat cattgttgaa 2194381 aaagcccttc agcaagaacc aaaaaagaaa agaatcgtta tgtggccgac atcagcagca 2194441 atcgctgcag ctattttatt cactgcgctt gttaatatca acccggacgc cgctcaggct 2194501 atgtcaaaga tccctgtcat cggcaaaatc gtcaaagcga tcacctttat tgaaatcaaa 2194561 gaggaaaaag accaatcaag cattgatgtc aaaacacctg ctttgtccgg gctttctaat 2194621 aaagagcttg aaaacagcat taacgagaaa tacttgaaag aaagccagca gctgtataaa 2194681 gagtttatac agtccacatc caaaaacaaa aaagggcatc tcagcatcta cagtgattac 2194741 gagacggtca cagacacgcc agatttactc tctatccggc gcaatattga aacaacacaa 2194801 gcatcttcct acacacaaag ccgttatatt acaattgaca aaaagaatga tattttactt 2194861 acattaaaaa gcttattcaa agatgagcgc tatatcaaag tcatcagtca aaacatcaaa 2194921 gaacaaatga aacagcaaat gaaggaagat ccaaataaaa tatattggct cactgacgaa 2194981 gatgcagaac cgttcaaaac gattcttcct gatcagacgt tttacattac tgaagaccat 2195041 aaacttgtga tctcatttga cgaatatgaa gtcgcccccg gctatatggg cgttacagag 2195101 tttacaattc caaccggcgt catttcaaac ttgctcgtgg gagaacgtta tattcgataa 2195161 aataaaaaca tccatctaag attatggatg ttttctctct tctctattcg aggtcgtaac 2195221 cccgctatca aaaacaacga gaatatttgc atactattgg aggaataccc atgtatcaca 2195281 agacacagca tcatcgatac attcctggac ttgatggcct tcgggctttc gccgtcctgt 2195341 cagttatcac ttatcaccta aatttcaatt gggctaacgg tggttttatc ggggttgata 2195401 tcttttttgt tttatccgga tatttgatta catctattct attaccggca tatggaaatg 2195461 atatcaatct tgattttcgg gatttttggg tgcgccgcat tcggcggctt ctcccggcag 2195521 cgtaccttat gatcttttcc actgttgtgt gggtcgtatt gtttgatcga gaactattgc 2195581 acactgtacg tggagatgcg atctcttctc tcttttatat gagcaattgg tggtttattt 2195641 ttcacaagct atcatatttt gatagtttcg gttccccatc acctctaaaa aacctttggt 2195701 cgctggcgat tgaagaacaa ttttatatca tatggccgat gtttttagtt gttggaatgt 2195761 acataatgaa aagccgcgcc agattggctg cggtgatatc attgcttgtg ctttgttcag 2195821 ccgtgatgat gagcgtactg tatgaacctg gcggagatcc gagccgcgtt tactatggca 2195881 cagacactcg ttcgtttgaa cttctcatcg gatgtgcctt ggctttggta tggccgatga 2195941 aaaggctgtc ttccaacagg ctgccaagca aactgaagca cactttgcac gccactgaat 2196001 ttttggcatt ttgtatttta gtgttgtgtg tctatttcac agatgaatac gagccttttc 2196061 tttacagagg cggaatgcta ttcattagcg tgactgccgc aatccttatt gcatgtgttt 2196121 gccatccgag cagcttttta ggcaatctgc tttcatggag gccgcttcgg tggcttggaa 2196181 cgaggtctta cggaatttat ctttggcact accctgttat tgtgttaagc acgccagttc 2196241 aagaaatcgg aaaccctgtt ttttggcata tcgtgctaaa ggtcattgtg acatgtatac 2196301 ttgccgagct ctcctaccat tttattgaga agccgatacg gacacaggga tttaggtcat 2196361 tttcccgccg tgtttttata catagaatca aggaatggaa aacgacatct gtcatcagca 2196421 aaatgtcaat tggtttcatt attttcgcta tacttatttt tgcaggcggg ctgtcagggc 2196481 tagccggcga gcaaaagcac cctaccaaat ggacctatag ctcacaagaa acaaatgctg 2196541 acaccagcca ggcttctggg gataaaaaga acgctgcagc agataaaaaa cacaatcctg 2196601 aacaaaagac aacagattcc aatcagggtc aaaaggaaaa caaagatagt gggcaagaga 2196661 ctcataaaaa gaaagacacg caatcccaac agttgaaaaa accagcagac actgcgaaag 2196721 aagttttagc tataggagat tccgtcatgc ttgatatttc ttcacacctg cgtcagtcat 2196781 tttcaaatgt gacgattgat ggaaaggtag ggagacaaat gtctcaagct ttggaactcg 2196841 caagggaata caagtctttt aatcagccga acaaggctgt catcattgag cttggaacca 2196901 atggctattt tacaaacagc caaatcgaac aactgcttca atctttctca aaagctcata 2196961 tttatcttgt caatacacgg gttccccgcc aatgggaaag caaggtaaat gaatctttgc 2197021 agcaacaggc ccacgcacat caaaatgtta cgttagttga ctggcataca gaagctcttc 2197081 agcatccgga atattttacc cctgatggtg ttcacttggt tcctaaaggg gcaaaaactt 2197141 tgactgctct tattgttcag gcgatgaaat cgtaaaaaag agatcctata cagatcactt 2197201 ttttacttta gtttctgatc gttgattatg tcttctttca gcaaggcagc ccttatgttt 2197261 acatgccgtt tacgtaaggg taagccaaaa ttgaatggag ggatgataat gaaaggaaat 2197321 gaagaacatg acatccaaaa agagttgaaa cgatatgagc tttttttcaa aaaacgatat 2197381 aaggttcttt atacagtaaa cgattttatc atcggtgcta tgtttctcgt tggaagtttt 2197441 ttcttttttt atgaccggtt aatgtcggca gggatatggc tgtttgcgat cggaagtttg 2197501 ctgctgttaa tcaggccgac cattcggctg attcatgact ttcattaccg taagcatgtg 2197561 gaacagcaat tcaagcatca atcttcaaca gatgactgat cttaaggaat aagaaagaac 2197621 aaaatgccaa aagcctgagt cgaaaatcaa aaacaagact ttcagactat ttatttttaa 2197681 aaacaaggta aaaagaacta aacttttgcc tctgcatgcc gatatgaata ataaggccgg 2197741 cgcgatactc cctataacat ccttttcagt agatttcatt atcgtgccgg ttttctcata 2197801 tgcaaagcaa tcccgccaat cagattggcg ggattttata ttttacattc ctgtccaaac 2197861 gtctttcaca taacgtcttt gatcttgcag cttttgcagc catacagctg attcttcctg 2197921 acttgctgct ttttcagctt catatgccaa tcgcaaagtt ctctctacat caggagccat 2197981 ttgcgatcca tcaccgcata cgtaaatatg agcccctttt tcaatgagtg tcatcaattt 2198041 ctgcgtatct tgcttgagca agtgctggac atatcctttt ggttcgtttt cgacgcgcga 2198101 gtagcatcgg cggattgtga ccaaaccgtc ctgttccgct tgatccagct cttctctgta 2198161 aaggtcgtca tggtccgggc ggcggcagcc gaagtataaa agtgcttcac caagggtgct 2198221 tccttccttc ttcaaaaccg atcttgcctg aataaagcct ctgaatggcg caattcctgt 2198281 gcccggcccg accataatca taggcgtttc aggatcattc ggcatctgaa atccggactg 2198341 cggcgtacga atgaagcaag ctgctgcatc acctgtattc aattctgcta aataattaga 2198401 ggcgacaccc cggtattcac ctcggccgct ccatgctgag gctttcacaa ctcctaccgt 2198461 catgctcacg atatttgcat gaactttcgg tgagcttgaa atggaatagt atctcggttt 2198521 tagtgatggc aaaagtgcta aaaaccgttc aaacggcatt tcgcaagcag gataatcctc 2198581 taaaaaatca agcatggtaa gacgttttgc aagtacctgc tctttgtaaa tgccatcatc 2198641 tgaaacgagc tgttccagct ctttttgatg cggcggacaa actgtataag aggccagctc 2198701 ccgaagctga agccttgatg ccggttcctg cagctctaca taggacgaca ataaatccac 2198761 tactttgatt ggccgatcca tcggcagatg agccatatga gcgcttccgc ttacttttat 2198821 cacatgattg gactgcaaac cgaatcggct gagaacccgc tgaacaagct ccctgctgtt 2198881 ctttggcagg attccgatat gatcgccttc tttatatgtt ttaccagccg gaatttccaa 2198941 ttcaatatgg cgggttgaac gcgtgctggc agctgtctgg agttctcgat tctctaacac 2199001 aatcccttca aacgcgccat atgctttagc aaccggcgtt tccgtcgctt cactgagaaa 2199061 agtaatcgat aatgaaggcc tgtcttcttt ctgggctatt tcgttaatat caaatgcgtc 2199121 catcgtttcc ttccagaagc ggttttccca agactcgcgg tggctttcaa aatcatcggc 2199181 ggcgtcacct tccccaatcg ctgttaaacg cgatgccccc tttgctttca tcatgtcatc 2199241 aatcaggcgg ggaatccgct gatacgtgct ggcccagctc cggtttccgc agccgaatac 2199301 cgcataggaa acacctttca attggccttc ctcaagctct ttcagccact ctacaaatcc 2199361 ggcagcatta tcaggcggcg ccccattata agaagccgtt acaatgacga ctgccccttc 2199421 ttcagggagc ttgccgatat aatcatcaag cggagccgtt tcagctgtaa agcccatctg 2199481 gcggccttga gcagccagtt caccggctat tccctcagct gtcccaagat ttgaaccaaa 2199541 aagaacaagt aaaggtgtgc cgtgtttagg tttggtttct tttggctttg tttctgcttt 2199601 gatgtctgcc tgttcttttc tctgtacatt gattgccgct gtttttcgcg gtttcacagt 2199661 aattttaaaa tcatccggct tgatcgttaa tgcttctttg atttttagtt cgtagccagt 2199721 atggtttatc aattcaaaat gctttaatac aagaccgaga accattgtcg cttcttgaag 2199781 agcaaactgc atgccaatac aagcgcgctg tccgtttcca aacggcttat acgcatggtg 2199841 agggatactt gaaggatcct caaaccgttc cggacggaaa tcttccgcat ccggtcccca 2199901 agcgttttga tcccggtgca gttttggaat taaaacagtg actggctgcc ctttgctgat 2199961 cggatattcc ccgcctagaa cagtatcctc cttcgcatat agagaaaaag ccggagctgt 2200021 tggatacagt ctgagggttt catttaaaac catccgaatg tatttgagct gctggatttg 2200081 tttatattca ggcgtgtcat ccgttaacac gcgatccgct tcctcctgag cttttttcag 2200141 tttttccgga tgtgtaagca gacaataaat cgcaaaggat agcaacccgc ttgttgtctc 2200201 atgtccagca attaaaaatg tgatgatttg gtatcgaatg ttttcgtcat ccagcgtttc 2200261 acccgttact ggatctttgg cataaagcat gagagacaag agatccttaa tgttttcatc 2200321 cggattcgcc tttcgctccg ctatcattct atcaaccagg gagttcatga cttctatatc 2200381 cttttggaac tgcagcttcg ttttcaccat cattttatct tgcaggccca gtcttttcga 2200441 ttgattcatc gcctctttta aggcacggag catactggtg ataaacggat gctgtgaatc 2200501 acggtaaaag ctgttgaatc gatagttaaa cccgcataac ccaatcgtat caagcgtcag 2200561 acgtgtcata tcgtccgcta catcaatttc ttcattaggg tttaaccggc tccacttttg 2200621 aatcagctgg gttgcgatat ccagcatcat agaatgatag cctttcatcg ctttttgact 2200681 aaaactcggc agcaaaatgc ggtgggcttt ttgccagttc ggttcgtgcg tccagcttgt 2200741 aaataagcca tctcccccga actcacgcac cttttgcaag cctttgccaa ggttcttgtc 2200801 aaagcgtttt tcatcacaca cttcagccac aagattgtgg ccggacacaa aaacactgga 2200861 tactcccgga aaatcaaaac ggaaaatcgg tcccaattca tcagctatcc gccataagga 2200921 ttgagaaagc tgttcttttt ccagatgcgg aagatttttt aaaggtccgt atgttttggg 2200981 ctgaggtatt gcgcttgcct gtttcattaa catctccctt tcctattttt gtgatgaatg 2201041 aagcttaatg gcgtcccagc agcattgttc caattcagta attaaatcag tgtccatctc 2201101 tatatcacct gtttgaacga gctgatatat cttgagaaac gcccctaata caatcgcaat 2201161 taacacatta gagggcaggc tgcgaatcac gccttccgct tttcccttat taaaatagtc 2201221 atcaagcatt tgagtcagat tttctatcat ttttttgctt gtatgattta agtaatgagc 2201281 gtcttttttg gtttcaagaa aaaaaagcgc atagtcgctc tctttcgtaa actgaacgag 2201341 acagcaaaat acgtggtgaa agccttctct gacaggcaat tctgaaacgt cttgcttcag 2201401 tttttccgta aatcgctgga tgctttcttg aaacagtacg ttaacgagtg tttctttgct 2201461 gtcaaaataa cgatagatcg ttcctgtccc tacatgagca cgttcagcta tcataggaat 2201521 agtggtagcg tcaaaacccc tttccgtaaa aagtgagact gacgctttca taatcatgtc 2201581 gtatttactg ctggatgcgg atatcatgta atctgacaac ctccgattcg tttacggaat 2201641 gaatattcat tccttttgtt cacaaagaat gtctgccctg tctgatatca cctctttgtt 2201701 ctttcttctg ttataagttt atatgaaaaa aacttttttt aatataaagt atatgcaaaa 2201761 aataaaaaat taagaaaata tacccaaatc ctaatacgag gatcttggat atatttcccg 2201821 agaaattttt tatttaacag ccacaataca tagacaggaa gcacgcctga taacagaaag 2201881 atccctgaaa tgctggtctt tcagcagttg aatatacgtt ttctcttttt caccggtatt 2201941 tgtgtcaata ctgatataaa accggccgtc aatttgaagc accctgtaaa tttctcttaa 2202001 tgcaagccta atatcggtgc agctttgaac cgtatgtaaa gaaaagactt tattaaaggt 2202061 acggtcatca aagggaatgt cctctggata gccatgaaaa acctccccgt tccccatgtt 2202121 ctttcgattc gcacgtgata tctgtcttac ctttcgtttt gaaggatcaa tgctttttag 2202181 gctacccttt tttagtttct tggttatgct tttaaagaca gtgccgtttc caattccaat 2202241 ttctaaaatt ctgtcatttt cttgtatatc tatagagtca atcatcatat gctcaattgt 2202301 tttggttagc ttatatttcc gagaaaataa tttccaaaaa tccgatcgtt tatagagtct 2202361 attttctagc attttaaaca cctgcttttg gtttcctatg tttatttatt atcttaaaaa 2202421 aataaacatc atcttcattt ctaaaagtga aggaaggtac caactagacg gcaatgtatt 2202481 gaaaaatgtt tcaatagaac taaacttttt catttttttc cgaaaaaaaa gcagaaaaca 2202541 taatgttttc tgccctcttt ctaatgccaa tgataaggga atacatacag cctttgctgc 2202601 tgcattgcca tcagcctctg ctgtcggaat ggatttccat aaccatgttt gaaggaatgc 2202661 ggcatggacg cataaccatg gccaatcgac ggcagtcttt tttgataatc gttcatcatg 2202721 ccatcacctg cctcacaata acgttgattt actatatgca ggcgcgcatt ttcttgacag 2202781 ctatttcgct aaacttggtc cttctccatt gtataatgca tcaatagttc cattctaagc 2202841 atatgccatt cccccttcag tttttttcgt tgcttttagc gccagtttgt taaataaaga 2202901 tgctttaact gagactcttt catttcatca taaatttgtt caatctgctg ttctcgttcg 2202961 aattcttcca ggcttttaaa ccgtttttta atcgttaacg ttaaaaagaa taggttaatc 2203021 gtcatatcgc tcaccccctt tcaaagtccg catcaagcga aataacccgc ggcacaaccc 2203081 ttctgccgcg ggcaaataaa aaccgcagac aaaagaagac accaatgcct ctactgcctg 2203141 cggggagttg cgtatgtccg actattccga atttaatgcg tgcgataagc atcggttaag 2203201 gaaggacacg aactcttcca caggctgaat aaaccatgaa cttttacatg tgtatcacgt 2203261 acaggttgac gtcgttgtct cattgtcatt ttggttcagc ctcctttgct tttttcttac 2203321 tttgtaagta tatccaccaa attccatttt gtaaacatct ttttctaaaa atggacggaa 2203381 attgtgcaaa tcatcgaatg gatttgcccg ttggtcatga cacctgcttc atttcttttc 2203441 tggagcggtc tttcttatga tatgcaataa aataaatgag accgacaaat acagctccgc 2203501 cgatgacatt accgataaaa gccggaatga tgtttccgat gaactgcccc cacgtgaatg 2203561 agcctgcaaa aatggcagca ggaatcacaa acatgttggc gacaacgtgc tgaaatccga 2203621 tagccacaaa agccatgatt gggaaccaga tgccaaggat ttttcctgct gcgtcttggg 2203681 cgccgaaaga aagccacact gcaagacata caagccagtt acagccgatg gcggaaatga 2203741 gaaccttgcc aaagctcata tcaagctttc cttgggcaac ggcaatcgtt ttttctaaat 2203801 aaggacctgt ttcagtcaat ccaaccaaat gcccgaaaaa gtaagcaaca aacaatgcgc 2203861 cgattaagtt cataattgtg acgattcccc agttaatcgc taactctttt actgatattt 2203921 ttctcgaaaa taacgccatc gcaactgaca tcatattgcc tgtgatcagt tcagcgccag 2203981 cgagaacgac aaggatcagg ccgactggaa atactgctgc accaatcaaa ctggacaggc 2204041 tcccccattc tttcggaaga tcgccaatta ccctgatatc aagcaaatac ccaagcgcga 2204101 taaatgcacc gcctaaaaac cccagcacaa gcagtgacgg cagcgggagc tttatttttt 2204161 tcatccctgc ttcaattgct gcttccgcta tttcatccgg ttttcgaaaa gccataataa 2204221 aacgcctcca ttacttcttc ttttctcaca gttatgcaag aaaggcaata aaaaaggcag 2204281 cactcaaata acctgtgtca aaccaggcgt ttgaatgctg cctaacttgt atgcataccc 2204341 atacaacaat atcaagcagt atataagata ttgaaagaga atatatacag ttcgtgcata 2204401 cattccattg ctttagcctt ctataactgt agcaacatca tatcaaatgt gacaaatttg 2204461 tgtcaatgac aaatatacta gctttgcaga gcttcttttt gctcatctat ttttcggtca 2204521 aaaacaaata cagatacagc gatgttttcc tcaattttaa tatcagaaaa caaatggact 2204581 agcttagctc ccataagttc ctccattcct tccggtgttt gtttggaata aaggtcttga 2204641 attaggcttg tccgggccgc atgtaccatc tctcttcctt caggcgtgcg ggcaataaac 2204701 tgctcgcttg cactcagatt tccgtatagt gttgaaactg ccatgttttc tacaaataca 2204761 gtatgaattc tctcaggccc ttttccgaac aattctttgc gaagttttcg aataatatca 2204821 ttgaattcat gaattttttt agacatgctg attacccctt ccgatattgc cttataaagg 2204881 cttttcccgg ttcccctcag gacatttcac ttggttaaaa ttttcctgcc atattgtatt 2204941 ataataaata tcacattata ataaaagcag tgttgatgga tttgtaatag gatcttgtta 2205001 tgagtctatc gttttataaa aatcaaggat tggtctgtta gtaagacttg ctagtgaact 2205061 attccgccat gtgtgtttac accttcttag aattaagggc aggtgtatct atacatggct 2205121 ttttttgact tcttgaaaga aagatggagg ggaatatgaa tatgatggac gttaagtcga 2205181 tcagtgtccg tgtagacgga acagaaattc aagcacgagc aggggccaca attttagata 2205241 ttttaaatga aaacggaatt gagtacccgc agatttgcca cgtaccagag gttgacccga 2205301 ttcaaacttg tgatacttgc atagtagagg caaacggcaa gctggttcgt tcatgcgcga 2205361 cggttgcaga aaacgggatg tctattgatc tttcaggaaa tcgagtgaaa gaagcgcaaa 2205421 ccgaagcgat ggaccgcctt cttgaaaatc atttgctgta ttgtacagtt tgcgataaca 2205481 acaatggaaa ctgtacgctg cataatacag cggaaatgat ggggatcgag catcaaaaat 2205541 acccatacac gccaaaagaa gatccttctt gcgcggttga tatgtctcat cctttttacc 2205601 gctatgatcc aaaccaatgt attgcctgcg gccagtgtgt tgaggtctgt caaaaccttc 2205661 aggtaaatga aacactctca atcgactggg aacgcgaacg ccctcgcgtc atttgggatg 2205721 agggagttcc gatcaatgaa tcttcctgtg tcagctgcgg tcagtgtgta acagtatgtc 2205781 catgtaatgc actgatggaa aaatcaatgc tcgggcaggc tggttttatg acaggcatta 2205841 aagaggacgt catggaaccg atgattgatc tcgtgaaaaa tgttgaaccg gggtatggca 2205901 gcatttttgc catttctgaa gtcgaagcgg caatgcgtga aacgagaacg aaaaaaacga 2205961 aaactgtatg tacgttctgc ggtgtcggat gttcatttga agtatggaca aaaggacggg 2206021 atattttaaa gatccagcct gtttctgatg ctccggttaa cgcaatttcc acatgtgtca 2206081 aagggaaatt cggctgggat tttgtcaatt caaaagagcg gatcacaaag cctttaatcc 2206141 gtaaaaacgg agcctttgtg gaatcttctt gggaagaagc cctcgatctt gtcgcaagca 2206201 gattaggatc aattaaagag cagtacggta aaggctctgt agggtttatt tcttcttcta 2206261 aaattacgaa tgaagaaaac tacgtcattc aaaaactagc gcgtcaggta tttgaaacaa 2206321 acaacgtcga taactgctca cgctactgcc agtctcctgc tacagacgga ttgttccgca 2206381 ctgtcggcat gggcggtgac gccggcacga ttaaagatat tgccaaagca ggcctggtca 2206441 tcattgtcgg tgccaatccg gcggaaggac acccagtgct cgcaacacgc gtcaaacggg 2206501 cacacaagct ccacggtcaa aaactgattg ttgctgacct gcgtaaaaat gagatggctg 2206561 agcgatctga tctgttcatc agccctaaac aaggcacaga ccaagtttgg ctgatggctg 2206621 ttacgaaata tatgatcgac caaggctggc acgatcaggc gtttattgat gagaacgtca 2206681 attactttga agattataaa gaaaccctta aaacgtatac gcttgattat gcagaacgca 2206741 tcacaggcct ttcaaaagaa aacatcattc aaattgctga aatgattcgt gatgctgacg 2206801 gcacttgtgt cctttgggga atgggtgtca cacaaaatac aggcggttct gatacatcag 2206861 cagccatttc aaacctgctt ctcgctacgg gcaactatcg ccgtccaggt gccggcgctt 2206921 atcctctgcg cggacacaat aacgtgcaag gcgcatgtga tatgggaaca ttgcctggct 2206981 ggctgccggg atatcagcat attacagatg acaaagcacg cgctaaattt gaagaggcat 2207041 atggtgtcga gattgatgga aagcctggtt tagataatat tcaaatgctt catgccattg 2207101 aagaaggaaa aatgaaagct atgtatcttg tcggtgagga tatggcactg gtcgattcaa 2207161 acgcgaacca tgtgcatgat attttatcaa gccttgattt cttcgtggta caggacatct 2207221 tcctgtcaag aacagctcaa tatgctgatg tcgtcttgcc ggccactcct tcacttgaaa 2207281 aagacggaac atttaccaac acagaacgcc gtgtccagcg attgtatcag gcgcttccga 2207341 cgcttggtga cgcaaaaccg gactggtgga ttattcaaga ggtggcaaac cgtttaggag 2207401 cgaattggaa ttacagccat ccaagtgaca ttttctctga aatggcgagt ctttctcctc 2207461 tgtttgccaa agcaagctat gaggtgcttg aaggctggaa cagcttccta tggggcagct 2207521 tcacaggtga aagcacaccg cttctgtatg aagacggatt taatttccct gacaaaaaag 2207581 cccgctttgc cctttctgat tggaccgagc cagcggcatt tccggaggaa tatgaccttc 2207641 atatcaataa cggccggatg ctggagcatt tccacgaagg aaacatgaca aataaatcga 2207701 aaggcatcca agcgaaagtg ccgaatgtat tcgttgagat ctcacctgag cttgcacaag 2207761 agcgaggtgt ttgtgacggt tcgcttgtac ggctcgtttc tccgttcgga gcagtcaaat 2207821 tgaacgcgct gatcacagac cgggtacgga aaaatgaact ctatttgcca atgaactcga 2207881 cagacaagga gtcagcgatt aacttcttga cgggccctgc agctgataaa cggacgaaca 2207941 cgcctgctta taaacagaca aaggtccgca tggaagtgct tggcggctgt gaaacagcgc 2208001 cgcttccaaa aacaaatccg cgcaacaaaa aacggcatcc gcaaaacgga gtcgaagcag 2208061 aaagaaaatg gaaccgccct ggctatgtac atctgactga ttaaacgata ggaggaaaac 2208121 gaatggccac tccgattacg acgatcaaaa aagaaacaaa aacagctgag caaattaagc 2208181 ttgaaaaaat agaagaactg aaagagctgc tggcggaaaa tgaggacgcc gtctctaaaa 2208241 cgatgacgtt aatgaatgaa ctcaatgatc ttggaatttt tgatgcggca acaagcatgc 2208301 tcagagcgaa ggaagacatt gccaagattg cgcttggcca agtttcccgc gagcctgtca 2208361 ccaacctcat caacacgatg atggccgccg gaggcgcatt gacaaaagcc gatcctgagt 2208421 ttacagcaaa gcttttagaa agcgtaatgg ctgggactga acaggcacaa agctttttaa 2208481 aagaagacaa gaaagtcggg attctcgacc tgttaaaagc aatgaacgat cctgacatca 2208541 acagagccgt cgggttcggc cttcagtttt taaaaggcat gggaaaagaa cttcgagaac 2208601 aataacagaa aaacagccat ctctgatgat ggctgttttt ttattcgtcg gcttcttcca 2208661 gacgcttctt gtaaataagt gaacggtcag cgcaaaagaa ggcaccggct aaaaatacgc 2208721 aatccgctaa aaacatcgtc gatttctggc ctaatgttaa gccttgatca gggagaactg 2208781 cgcctatata taaaaaagtg ctgactgcaa gcaatgtaaa agcaaaatgc ttgtagtctt 2208841 cttttaaaga tttcattcta tttttgttca aaagaatcac ctgccagatt catagtatac 2208901 gactattata atataatccg gcggcttaca gagaaagtaa ttctatccat ttgttatata 2208961 ttttcaagcg cttggccgat atcttccaac aagtcttccg catcttcaat tcctacagaa 2209021 attctgatca agccgtccgt aatgccgagc tcaagccggc gttctctcgg aatagaggca 2209081 tgtgtcattc ttgcaggaac agaaattaag ctttcaaccg cccccaggct ttcagcaatg 2209141 gtaaacagtt tcagatttcc taaaaacgca tcaacccgtt cttcactgcc aatatcaaag 2209201 gagatcatgc cgccgaagcc cgctccttgc gtttttgcaa gctcatgtcc gggatgattt 2209261 gaagaaccag ggtaatataa cgtttggaca gcagggtgat tctcaagaaa gcttgcgatt 2209321 ttccgcgcat tttgatcgat cgcttccatt ctgagtccca acgttttgat tcctctcatt 2209381 aacagccagg aatcttgagg gccgagcacg ccgcctgtgg agttttgcac aaaatgcagc 2209441 tcttctccaa gctctttcga agctgtcaca actaaacctc cgacgacatc actgtgtccg 2209501 ccaagatatt ttgtcgcact gtgcagtacg atatcagcgc ctaaagtaag cggctgttga 2209561 aaataaggag tattaaaggt attgtctacg ataagcagaa cacccgcttt ttttgcgata 2209621 tcagccatga gcgtcaggtc ggtgattttg agcaacgggt ttgtcggtgt ttcaatataa 2209681 attgcttttg tattagggcg aatcgctttt tcaacttctt ccctgctgct cgtatcaaca 2209741 aatgttgatt caatgccaag acggttaagc acctttgtca tcacgcgata tgttccgccg 2209801 tacacatcat cagtcaacac gacatgatct ccgctgttaa acagcatcat aaccgctgta 2209861 atggcagcca ttcctgagct gaacgcatag cctgcttccc cgctttccag ttctgtcaca 2209921 agtgcttcga gagcggttcg agtcggattg gccgttcttg aatactcgta gcctgtatgc 2209981 tgccctgctt tcggctgctt gtacgtgctt acttgataaa tcggcacgga aactgcgcct 2210041 gttttctcat cacctgtgat tccgccatgt atcatcaatg tttttttctt catatcagat 2210101 gcctccttcg tatatttgtt tgctgatata tcgatcgctg ctgtcaggaa atactgtgac 2210161 aatgttagtt ccagcggatg cttttttcgc ttcctccaat gccgcataaa gcgctgcacc 2210221 tgaagagctt ccgatcagca ggccttcttt ttctgccgct tctttcacaa gtctaaacgc 2210281 attctcatct gttacggtgt agatctcgtc aaaatggctc ttatccatat aatcggggat 2210341 aaactccatg ccgatgccct ctgttttatg agcgtggggc tctcctccgt ttaaaatcga 2210401 gcccaccggt tcaacaatca ccgttttgac tgctggattt ttttctttta agaaggaagc 2210461 tgtccctgcg aatgtgcctc ctgatcctgc ccctgcgaca aatgtatgaa tattcccgtc 2210521 aagcgcttcc cacatttcag gtccaagcgt cttatagtaa gtcgatggat ttactcggtt 2210581 tttaaattgc aaaacgcaat aagaattttc aatttcagtc tccagctgaa tggctttttg 2210641 aatggctccc tgcattccgt cttgacgcgg tgtatgaatg attgatgcgc caagcgcttg 2210701 cataatttgc tgtttctctc tgctgaaatg ttcagggaca cagaaaatcg ctttcagccc 2210761 atattttctg gcacttaacg caaggccgat ccctgtattg cctgccgtag cttctataat 2210821 cactccgccg ggtttcactt tgcctgaatc gagcgcgtca cgaatcagca tatctcccag 2210881 tctgtctttg atgcttcccc ctggattcat catttcaagc ttggcataca ccgcgactcc 2210941 ttctggaaca tcaaagttct tcaagcggag aagcggtgta ttcccaatca gctcggtaat 2211001 gtccgtaatc actgtcatat atgtcctcct ccttaataga ggttgttttt agagaaaaac 2211061 ggaggagaac gttctccccg ttttaatgaa ttcgtttgat cacctttaac acaagctctg 2211121 ttgaatgaac agccgcctgc tctaaaaatt ggtcaaatga aacatgtgat tctttgcctg 2211181 cgatatctga taacgctctg atgacgacaa acggcgtttt aaattgatgg catacttgag 2211241 ccactgccgc agcctccatt tcaaccgcgt acagatcaga aaatctcgca cgcacctctt 2211301 caacccgctt cggatcgttc atgaaagaat cgcctgttgc aatcgttcct tttgcaacct 2211361 gaatgccgtc gagttcagat accgcttctt cagtgatgct gatcagcttt tcatccgccg 2211421 cataagcagc cggaagaccc ggcacttggc cgtattcata gtcaaaagcc gttacgtcta 2211481 catcatggtg gcgaacgtca gtggaaatga cgacatcccc tacattcaat gtatgatgaa 2211541 atccgccggc tgagcctgtg ttaatgacat aatcaggctt gtaacggtca agcagaagcg 2211601 tcgtgctgat agcagcattt acttttccaa ttcctgattt taaaagaatc acttcagttc 2211661 cttcatattc gcctgttgta aattcacagt gtgcgatcgt ttctgttttt gcattttcaa 2211721 gtttgtttct taagatggta acttcctctt ccattgctcc gatgactgct agtctcatct 2211781 attcacattc ccttcacttt accgtttgat cgcctccatt atccacacga agtcgttttg 2211841 ctgagtgaat cggactgcaa aaccttcagc tgtaaacatt tctttcaacg catccaatgt 2211901 aggataatgc tctgtctcta aatcatttgc aagctgataa aagccttgag aacgggcttt 2211961 atcgatagcc tgttgatacg cttgcgcatt ttcaaagacg gtatcggcaa acactatttt 2212021 atcatgcaag tgaaggtatt tgccatattg ctttatggca gcccgctttt cttcgtcagt 2212081 caaatgatga aaagcatatg aactgacaat cgtatcagcc tgaaatggcg gctcagggaa 2212141 tgtcaggaag tctccatcaa cgatttccgt cctgcctgag agcttgtcag aagccagttt 2212201 acgcattgct ggagaaggtt cgattccaaa tacagttttg cctgcatcga gcagcttagc 2212261 tgtcaaattc ccggtccccg ggccaaattc taacacatgc gttccagatt ttctgacgat 2212321 ggcatcaagg atatgatcgt agcctctgaa cgcttcttta tactgaatat ctaaaccttg 2212381 tactgtttga tcataagttg ctgcccaatc ttcaaagaga gggataaatt cacggcccat 2212441 atttgtcaca ctccatattt aataattcct ataagtatac tatggattaa tgatggaaca 2212501 gttcctataa taccacatat tctgaaaagc aggtactaaa acactttgtg tattttatgc 2212561 catctcatat tgcgcattga ccgcaaaaaa gcttatactt catatgactt gtgaaagctg 2212621 gagggtcaag acatgaattt tcaattagat ctgattaaag acaaagtgga attttttgaa 2212681 gcggcttcat tgcaggagct tgaaaagaaa atcaatacac aaattgaaaa caataaagcc 2212741 atcatgctcc gggtgaaatc tgtttcacac caaactcttg tggcagaagg aagaatattg 2212801 tacagcgcgg tggttcattt ctcagctgaa gcctaaaaca aaagcagccg gttttaaccc 2212861 ggctgctttt gtttatttta gcttttctac ttttgtcggc ttccagcctt tttcatcgac 2212921 ccatgtaatc gtgacttgat atttattccc agtcgccttg tccaaaatct tgcctttggc 2212981 atcctgaggg ctgccgttat ttccaagcca gagcaccgtc atgttatctg ttgagacacc 2213041 agttgcgtac gaaatggctt tcagcatctc agcccagtct tgtgagcttg aatcataagt 2213101 agcggcatgc tcgccagtct gctcagttcc gactgctttc cagtcaggat tttcatacgt 2213161 tttttccaca tcgctcgatg agccgccttc tgttactttt gcatctttaa gcccgtcacc 2213221 ggctgaatct gagcttgaat ctgaatcaga gtcatctttt ttagaagaag aatcatcttt 2213281 tttggaatca gagtcagaag acttctcaga atccttttcg ctgtcagatg tatctttctt 2213341 gctgtctttt atatcctcat ccgatttctt ttccgtcttt cctgaagccg gagattcctg 2213401 tttttgcgcc gtttcagaat ccttgctgac atctttgcta gaaggactgt taatgaagag 2213461 attcgctgct actacgacaa ttagtatgga tacgattgcg attaaaatgt taagcactaa 2213521 attggctttt ctgcgtttat cacgattttc ataacgagat tgattattgc tcaataattc 2213581 tgcactcctt tatccctctt ggctcagcat atattttaac atgtgctgag aagttgttct 2213641 atttctgatt gatttcaatt tcgtgtactt ttttaacaat atcataaaac accgaatttg 2213701 tcagagcctt atctcccggt gtatccatgt gtaaaacaac tagagcgtat ttcggcttat 2213761 ccgcgggaaa atatccggca aaccattttt cgtagagcgt ttccttctct tttgaaagct 2213821 tgcctgtctg ggctgtgccc gacttccctg ctacagtata cggaagatct tgaaaccttc 2213881 tgcccgttcc ggaaggagat tctactaccc gccgcagtat tttttgaagc tgctgtgacg 2213941 tatatttgtc tatcgtttcc cctttgagct tctgatcttt aaacgtaacg agcgttgtgc 2214001 cgttcttata ctcaatttgt tcggcaattt tcacctgccg tttttctccg ccgcgggcga 2214061 ttgtcgccat catattggct acctccagcg gcgttacctt tacatttttc tgcccgattg 2214121 ctgtttgcgc aatggctttt ttgactgatt tgtctttttc atccccccaa atcacgccgc 2214181 ttttttcgtt atacagctgg cggaaatcgg tttcgtggta cagttttccc tcccagcctg 2214241 cccgatcagt gagagccagc ttctcggaca tatcttcaat aaccgagctg tcttttttca 2214301 ttaattgttc tgcaagactc gtaaatgtgt aattacagct ttgggcaaaa ctttcatcaa 2214361 aagacaaggt gcctttgtcg tcccccggtt ccccgtacag gtttaaattg caattaaagg 2214421 tttgactagg cttcaccata ttattttcga ttgcagctgc ggcaatgact gttttaaaaa 2214481 ctgatccggg atagattggc gtcagcatat aattttgaag tgtgttttgc cgggacacgt 2214541 ctgcatctgg tttgcttaca attcccagaa cactgctatt ttcgatgtcc agcagcacag 2214601 ctcctccctt tttcagcccc tgttcatcca atacctcctc catcgctttt tgaatgcttt 2214661 gatcgatcgt tgttttgatc tggagcggat aaaatgtatt ggcttcagct gtatatttga 2214721 cgtccatgcc aaacaaaggg tttccttttc cgtccacatg atataaaagc tttgtgtctt 2214781 gttccggaag caaaaactcg tcaaatgtcc gttctaaacc ggttgttccg atttctgttg 2214841 taatcggaag gctctccttg tcaggatatt tcttgcgaag cagcgccgga tcttggttcg 2214901 tgctccctat cgtatgtgaa gcaaggctgg gcttgtcttc attctccata tatacgccgt 2214961 aaatgccggg atatttcaaa gaattgattt ttgtgataga ttgttttgaa agtgttttga 2215021 ttttcttttg ctgcaaaatg accggttttt ttgcctgacc tagtgtctgg cgcaaatcat 2215081 cttcagacat gccgaggatg tccgcaactt ttttgatcgg ccaatcctgc gtcagcagaa 2215141 aagggaacaa aacaaccgca ggctcgcttt gtcctgtcag cgcccgcccg tttcgatcta 2215201 aaaaagagcc tcttccatct gaaatgagca cttcctccgt ccgctgtttc acactttctt 2215261 gaatcaaatt aattttcttt ttagaaaatg attctgtgaa aaacagctgg atttctgcaa 2215321 gtctcagcag aagcagaaaa aatacaatca aaaaagcgat gactgccagc ttcattcgtt 2215381 tcgatatctt cataaaaaaa cacctcaccc acattgtgga cgaggtgttt cgctgctaaa 2215441 cagatattat gaaattttca caattttcac gagcatttct ccgcccggtg tttgtactgt 2215501 gacttcttca tctacttttt tgcccaagag gctttttgcg atcggtgaat cgtttgagat 2215561 tttcccttca aacgggtcag cttccgcgct tccgacgatc gtatatgatt cttcatcacc 2215621 gtcaggcagt tcgacgaaag tgacggtttt acccaaaccg acaacgttag agccgccgtc 2215681 atcttcaatg attttcgcat tgcgaatcat attttcaaga gtcgtcacgc ggccctctac 2215741 aaatgcctgc tcttctttcg ctgaatcgta ttcagagttc tcggaaaggt ctccgaagct 2215801 tctcgcaatt ttgattcgct ctactacttc ttttcgttta accgttttca aatattctaa 2215861 ttcttgttca agtttttgtt ttccttctgc agtcatagga aaaactttct cttgtgccat 2215921 gtcccttcac tccttctggt tgtccctcaa catcttcgat tatgtatgag agcataaact 2215981 aaaaaataca agaatgagaa cacagggcag tcctcgttct tctctcccat ataggtactg 2216041 tttatcttaa actgaatcgt gtcgttctgc aaatatttcg cgtttataaa cagggaaaga 2216101 agggaattcg cacattccct tcctgcctat acataatatg gtcagagtta tttatgtcta 2216161 tgctatggta ttacaaaatc gcgttttgtt caagaatggt ttgaattttt gtgaccatca 2216221 gatcaattgc gacgtgattc tgaccgcctt ccgggataat aatatcagcg tatcgtttcg 2216281 tcggctcgac gaattggtta tgcatcggac ggaccactga cacatattgt tcaatgacag 2216341 aatcaataga gcgtccgcgc tcattaatat ctctcataat ccgtctgatg atacgcaagt 2216401 cagcgtccgt atcaacataa agcttgatat ccatcagatc acgaagcctt ttgtcttcaa 2216461 gaacaagaat gccttcaagg ataataacat cctttggctc tacgtgaacc gtttcttctg 2216521 aacgtgtgtg aagcttatag tcataaatcg gcttttcaat cgggcggtaa ttcaatagat 2216581 cttgaatatg ctcgattaaa tagtcattat caaacgcaag cggatgatca tagtttgtgt 2216641 tcagcctttc ttcaaacgga agatggcttt ggtctttata ataaaggtcc tgctggatca 2216701 ttaaaattga gtgtccttta aactgttcat aaatggaccg tgtgacactc gtttttcctg 2216761 aaccggaacc tcctgcgatt ccaatgacta ctggattctt acccatgggc tgttacttcc 2216821 cctttctcat catgttgctc ggataaatct ttttgtctag tttgaatttg acaatttgca 2216881 ggggatggcg ggcagcatct agctcatttc cgtcttcgtc ccaaatggtt tcaatcgtat 2216941 gtgtaaagtt ttcgatttct ggaccgaaaa attccacttc gtcgcctttt ttgaagaaat 2217001 tgcgctgctg aagcgtgacc atttgtgtat cttcatcata attcagcact aagccgacaa 2217061 aatcatatgt cgttttcttg gcgtgttcgc cgaacatttg ctcttcatag cctggcgttc 2217121 cttcaaagaa agctgtcgca gtgtccctgt tggcgcactt atcaagctct tcaagccatt 2217181 ctttttgaat cacaaagttt tctggatcag cgcaataagc atcgattact ttgcggtata 2217241 cgctgacaac agttgctaca tagtgaatgg atttcatgcg gccttcaatc tttaagctgt 2217301 cgatccccat ttcaatcatt tttggaatgg attcaatcag cttcaaatct ttcgggctca 2217361 tcgcaaatgg tgcatcttct tcaccataca aagcaacggc gttggcaccg tctgtttggt 2217421 agagatcata atcccagcgg catgactggc agcagcctcc gcggttggaa tcccgcgctg 2217481 tcatgtgatt gctcagcacg cagcggccgg aatatgcaat acacattgcg ccatgaatga 2217541 aggattcgat ttcgatatct accttttctt tcatttctct gatttcaaga gcgctagttt 2217601 cacgtgccag cacgacgcgg tcgagacctt cttccttcca gaactggaca gccttccagt 2217661 ttgaaagaga ctgctgtgtg ctcaagtgaa cctcaacatt cggcgccact ctgcggcatg 2217721 tttcaataat aagcggatct gccacaataa taccggcaac gttggcgtct ccaagcgctt 2217781 ttaaatagtc ttcaagcccg tccatgtttt cattatgagc gaaaatattc gttgttacgt 2217841 agatcttcgc gccatatttc tttgcgaatt caacgccttc tgcaatttct tcgatcgtaa 2217901 agttatcggc attcgagcga agcccgtatt cctgtccccc gataaagacc gcgtccgctc 2217961 cgtaatgaac agcgattttc agcttttcaa gattacccgc aggtgcgaga agctccggct 2218021 ttttcgtaat cacacgcttt ccattaacga ttgtggatat tttatcattt acggcagtca 2218081 tagcttaacc tccttttgat taataaaccg tttccttgaa gaagaatccg gtatcaattt 2218141 ttctgtttac tggctggatg ctttcaatgc gttcgatcca gtcttctttt ttcgcttcgt 2218201 attcgtcacg gttttccacg cacaaatcaa ttgcttctct gtacattttg gtgacttcta 2218261 ttaggtattc aggcattttc aaaacaccat cgattttgaa agaatcaatt ccggcatcta 2218321 tcaattcctc gagctcatca atgatgcaca catcgttcgg gctcatgatg tgagtgccgt 2218381 tttcatcttc gaaaatcgga tatttattat cgcgttcttt atcgtgtaaa aacatgcctg 2218441 attctttttt ctttctttca atgtccatga ctttgccctg atattcaaaa tagtttccaa 2218501 tcaaagaacg cttcgattgg aacatgcacg tcattccatg cacctggatt tcaatttcga 2218561 cttcagcatt ttctttaatc tcaacaatgc tgtccatgtt taattctctg gcaagcacag 2218621 aacgcgccgc acccttgcgt ccccagtagt tgcatgtata atagttggtg cctgtcgttt 2218681 ctgtgctcca atgaagcttc agatcaggcg cagattcacg ggcagccatc agcacggcag 2218741 gatcgccgaa taccgctgca tcgacaccgg cttctgctaa gaaagccaga tattcgccaa 2218801 gctcacccac tttatcatta tggaaaattg catttacagc aacgtatact tttgcccctt 2218861 ctttgtgagc aatctctacg gcttttgtta catcttcacg agaaaattct ccggctaatc 2218921 tcaagccgta tctctgttcc ccaactaaaa acgcagttgc cccagcctgt atgagcggca 2218981 aaatgtccgc tgtactcgtc ggcgtcacta agagctctgg ttttttcatg acgttcacct 2219041 cttcttttta ctaatcgcaa gtccgtcccc gacaggaata atcgcagttt gataatccgg 2219101 atgattcatc agccaatgat tatattcatc aattttggct acaagcctgc gccttctctt 2219161 cggttctatt ttgctgtaat cctctgccac cagaccttta aacagcacgt tgtctgttat 2219221 aatcaccccg tccggtgaaa gcatcggttc atataaatga aaaaagtttt gatactgacc 2219281 ttttgcagcg tcaataaaaa tgacatcgta aggcgcggtt acatgaacgg cgtcggctaa 2219341 ttcaagcgca tctccgtaaa aaacatgaat ccggtcatca agctgaaatt ccttgatatt 2219401 gtttaccgct tcttcatgcc gtttctcatt gcgttcaatt gtatatattt cagcagacgg 2219461 cagttccaga gccattcgaa tggctgaata accaatggcc gttccgattt ctagtatttt 2219521 tttcggctgt ttcacagaca aaatttgaag cagcacctcc atgcccgctt tttccataat 2219581 cgggacatga tgttcttctg catatgcttc aagtctcttc acgttatccg gccgaggctt 2219641 taataatgct tctatatagt catttatttg ttcataccgg tcagtcacta caaacagcct 2219701 cccgttctaa aaaggagtgc cccagtctta tgcgcaggac actctctgaa tacatcatga 2219761 tacatcggta aacaacccga tatattttat cataaaacct tgcggaaagc gaacaaaagg 2219821 agagcttttt gctctccttt tatttctcat tttttgagga aatgtatttt tcttttgctt 2219881 tattatgctc ttttagcgtt tttgtaaata cgacctcacc atttgatttg gccaagaaat 2219941 acagatagtc cgttttatcc ggatgcagcg ctgcttccca tgatgacatg ccggcattgg 2220001 caatcggccc tggcgtcagc cctgtgtttt tatacgtatt gtatggtgaa tcgatttcca 2220061 gatccttata aagaacccga tctttatgct tgcctgccgc gtacaggacg gtcggatctg 2220121 tttggagcgg cattttcttt ttcaggcggt tataaaagac gctcgcaatt ttatggcggt 2220181 cggctttttc agtcgcttct tcttctatca aagaagccat tgtcagcagc ttatgcacag 2220241 aaactttgtt tttcttcatt tctgatttat atgtttccac ataagaattt gtctgcttaa 2220301 tcattgcctt gataatgtct tcaagtgatg tgtccggatc gttaaaaggg tatgtagccg 2220361 ggaataggta cccttcaagc gggtgcttaa tgtttttatt gaaaacatca tttgtcacag 2220421 tgtccgggaa ttctttcttc agctgattga taaatgtttc atcgtccagc ttcgctatga 2220481 cttgtttttt agagtatttt gtttcatcag caatagcagc cgcgatttgg gtcagctgtg 2220541 ctccctcagt cactgtgatt tgaaaagcgt aacctgtagc cccgcttgtc agcttctgaa 2220601 taatggcatc taaatccata cctttattca gatggtagaa tccggcctga aacccggaag 2220661 cacctttata tttcacatag tactgaaacg ccttctcgct ttttatgaca tcatttttct 2220721 ttaatatcga tgcgatggct gaaacagacg aaccgctcgg aatgttaata ttaactgtcg 2220781 ttttactgtc tttttcaaca ggttcaagca atgatttccc atataaaaat gccccgccaa 2220841 tgatgagaaa cagcacaaca atggaagaca gtatgattct ttttttatta aaaaacgatt 2220901 ttttttgctg attgatatac attaggtctc ctcccatcag ctcttatact acatgattca 2220961 ttgtatttcg gcaatttatt acaaaaagag gcctgcataa agcagaaaaa agccggagca 2221021 gtatagctcc ggctttggtt tggcgcgatg ttttactctt cgtcttcgtc cgctaagaat 2221081 gtgtttagtg tttcttcgat catatcccat tcttcgtcag tttcaatcgg gaatagctca 2221141 ccgttttcac cgtcttcgtt tggcgtgaag ctggaagcaa gaatttctac ttcttcgtca 2221201 tcttttgatt cgattggata gtacaagaca taagatttgc caaactcttc attttcaaat 2221261 gtaaacagca cttcacaaag ctgttcattt ccttgatcgt caacaattgt aatatttttt 2221321 tcgccgtgtt ccattttctt cacctctggc tttaatttaa gctgtcaaga tatccttgta 2221381 aaatcataac agccgccatt ttatcaatga ctttttttcg tttttgcctg ctgacgtcag 2221441 ctgcaatcag cattttttca gccgccattg tggtaagacg ctcgtcccac agcacaacag 2221501 gaacattgta cgttgtttca agcactttcg caaatgtttg gctggcttcg cctctcgggc 2221561 cgactgttcc gttcatgttc ttaggaaagc cgagcacgat tttatctata gtatagtcct 2221621 ttatcagttc agataaacgg gataaaccat aatcgccttc tgcttcattt atctttatgg 2221681 tctcaatgcc ttgagcagtc cagcccattt catcgctcag agctacaccg agtgttttgg 2221741 ttcctaaatc gagtcctaat attctcattc tttatttacg cctctttatg ctgttctaaa 2221801 taagacttta ccaattcctc gattaattcg tctctttcaa gtttgcgaat taaattgcga 2221861 gcgtcacgat gcctaggaat ataagcggga tcacctgaca gcaagtatcc gacaatctgg 2221921 ttgattggat tgtagccctt ttcctgaagc gcgtcataca ctgtaatcag cacctcattt 2221981 acgttagtct cagcagaatc atcggagaaa ttaaatttca tcgttttatc aaacgagctc 2222041 accgttttgc acctctttcc caaattcgca ggcaaagttc agcctggggt cctaatctta 2222101 ccatcattct acactacatg ggcgaattat aaaacggatt tcacccaatc ttctacagaa 2222161 gccaaagctt cttctaattt ttccggctgt ttaccgcctg cctgcgccat gtccggacgg 2222221 cctccgccgc ctccgccgca aacttccgca gcttgtttaa ccagcttgcc ggcgtgaagt 2222281 cctttctcaa tgaggtcctt tgtgactccg gcagagatat taactttatc gttttgtacc 2222341 gcaccaagca cgatcaccgc agagccaagc tttgctttga gttcatcgac catagtgcgg 2222401 agatgattca tgtcttttgc atttactttt gccgcaagca cgtttacgcc gtcaacttct 2222461 tttactttcg acaggattgc tcctgcttcc acgttgccta gttttgcaag aagagattca 2222521 ttttctcttt gtgcatcctt cagttcagcc tgcagagccg cgacccgttt cggcacttct 2222581 ttgatatttg ttttcagctc gtcagcggtc tgcttcaata cagaaatctg gctgttcatt 2222641 tcgacgtaag cgccttgtcc cgttacagct tcaatccgtc ttgtgcctgc tccgattccg 2222701 gattcagaaa cgattttaaa caagccgatt tctgctgtat ttctgacgtg gcagccgccg 2222761 cacagctcta agctgtaatc tccaacttga acgacacgga caatatcgcc atatttttcg 2222821 ccgaacagtg ccatcgcacc catttctttt gcttcagcga tcggtttcaa atcaatgctg 2222881 accgggatgc tcgcccagat cttttcgttt acgattcttt caatttgttc gagctcttct 2222941 tttgtcactt ggccaaagtg cgagaagtca aaacgaaggc ggttttccgt tacaagagag 2223001 cccgcctgat tgacatgagt tccaagaaca tcttttagag cctgatgcaa taaatgcgtt 2223061 gccgtgtggt ttttaatgac gccgcttctc atatggtctt caacttcagc cgtaacatgc 2223121 aggccttttt gaacagtacc gctctccaca acaccttcat gcacatgctg gccgttcggc 2223181 gctttttgaa catctttaat tcttacaact gcctgctcgc ttcggagata gcctttgtcg 2223241 ccgatttggc cgccgctttc tgcatagaac ggtgtttcat caagaatgat ttgaacgctt 2223301 tctccttcat gagcctcttc gattaattgg ccgtcctgaa gaagcacaat gatattggca 2223361 tcagctttgg tttgagagta gccgacaaat gtgctttcaa ctgtcacgtc gcgcagtgcg 2223421 ccgccctgca cctgcatgct gccgacatcc tggcgggcgt ttcttgcccg ttcacgctgc 2223481 tggttcattt cctcctcaaa gccctcatgg tcaaccgtca tgttctcgtc ttctgcgtat 2223541 tcttcagtca attcaaccgg gaatccatac gtatcataca gtttaaacac atcagcacct 2223601 gagataacgc tgctgccctt gtctttttct tttttgatca tttctgacag gatcgcaagc 2223661 ccttcattaa gggtctcatg gaagcgttct tcctcggttt taatgacttt tgcgatgaaa 2223721 tccgctttct ctttcacttc aggatagaaa tcagccatga tttctgcgac aaccggcact 2223781 aaatcaaaca tgaacggacg atggatgttg atcgttttgg cataacgcac ggcacggcgt 2223841 aataagcgtc ttaatacata gccgcggcct tcatttgacg gcagcgcacc gtcactgaca 2223901 gcaaaggcaa ccgttctgat atggtcagca atcactttaa acgcagtgtc tttcacattg 2223961 tctttgccat atgtttcacc agaaatcgat tctgttgctt taatgatcgg aacaaacaaa 2224021 tcggtgtcaa agtttgtcgg aacattctgg atgacagaca ccattctttc aagacccatg 2224081 cctgtatcaa tatttttctt tggaagcggt gtgtacgtgc cgtcagggtt atggttgaac 2224141 tctgagaaca caaggttcca tacttccagg taacggtcgt tttccccgcc tgggtaaagc 2224201 tccggatctt ctggatcatt accgtatgct tcaccgcggt cgtaaaagat ttccgtattc 2224261 ggtccgctcg gcccttcacc gatatcccag aagttccctt ccagacggat aattctttct 2224321 tcaggaatac cgattttttt cgcccaaaac tcatatgcct cttcatcttc aggatgaacc 2224381 gtaacagaga gaagctcttt gtcgaagcca atccacttgt cgctcgttaa aaactcccaa 2224441 gcccatgtaa tggcttcttc tttgaaataa tcgccgatgg aaaagtttcc gagcatttca 2224501 aagaaagtgt gatggcgcgc agttttacct acattttcta tatcgtttgt tctgatcgct 2224561 ttttgagcgt ttacgattct tggattttcc ggcacgacac ggccgtcaaa atattttttc 2224621 agcgtcgcaa caccgctgtt gatccaaagc agtgaaggat cctcatgagg cactaatgac 2224681 gcgcttggct ctaccgcatg tcctttttct ttaaagaaat ccaaaaacat ttgacgcact 2224741 tccgcagaag ttaagtgttt cattgtattt cctcctctat aaaaatcgaa attctcttca 2224801 gtgacagcaa aaaagccctc cccctatgca aaccaacgtt tacacaggga cgagagctgt 2224861 ctcgcggtac caccctgatt acgggcattc atgcgcccgt cacctttaac cctgtaacgc 2224921 aggataagcg gcagtgatta actgcactca ggattagctt cctccgatct tctgataaag 2224981 ctcctttcag cttatggagc ttctctcttt aacagggctt cggcgtactc agatccgtca 2225041 ctcgagattc gtatgtattc tacgagaaat tatagacaag cggcacgccg atgtcaatgc 2225101 tccgtcctca tccgcaaaaa atggatcatc attactttta aaacagccgt cgcaggaaca 2225161 gccagaatca tcccgacgat acccgcaagc tcccctccgg caaggagtgc aagcatgata 2225221 acgaccggat gcattttaag gcttctgccg acaatgaacg gactgaggat atttccttcc 2225281 ataaactgca gaataaacac cgtaatcacc acaacaagaa ccgccttgac tgagatcgtc 2225341 atcgcaatta acaacgcagg aacagctccg atgaaagggc caaaatacgg gatgacattc 2225401 gttaccccag agataaggcc aagtatcagc ggatacggaa gcccaaatac ccagaacgaa 2225461 atgcctgcaa tcacgccaag aatcaagcag accaaaagct ggccgcggat ataatcgcca 2225521 agcgaatcat ccacatcccg caaaaaggcg ctgccccgct ttctccacga cttcggagtc 2225581 aagtaccata ctgtcttttt cattaactca atgtccttca ccatataaaa cacgagaaaa 2225641 gggattgttg cagcaattaa gaagtaatca agcacattgc ggatcccgct gatcgcaccc 2225701 tcgatcgttc ccgcaaaaaa cgcctccgtc tggcggatca ttttatctat acggtgatgc 2225761 ataccatcag gccagtcatc cgtatggtta tgcacatgaa gaagaagccc gttatacgtt 2225821 tcggcaaaca tgggtatatt ttctgacaaa tccgtcagct gcacgattaa aacaggcacc 2225881 cctttataca acgcccagcc aatcccgcca aaaaaaagaa cataaatgac caagatgctc 2225941 aaagtcctag gcaatccttt gccatgcagc cattctgtga ccggaagcaa taaataagat 2226001 ataaaaatag aaatgatcaa gggaataaag atcgttttta tgacgagcca aaagggtgac 2226061 cataacatat caagcataaa aaagacatag actgttaaca gaaccagcaa acaaatagcc 2226121 acccacaaca aaagctgcac cggtttttgg agcatctgct ttcacctcac ctatatcttt 2226181 tgaggtttac aaggaattat tctttatgtt tctttagtca gtcagaagtc atggacattt 2226241 tttcactttt aattttcaga aaagtttgat catttacttt ttggtcaaat tttctgatag 2226301 gaggattgcg atgatcacat ttcaaaatgt aaacaagcat tacggagatt ttcacgtgtt 2226361 aaaacaaatt aatcttcaaa tcgaaaaagg tgaagtcgtt gttatcatcg gcccatccgg 2226421 ttccggtaaa agcacattgc tcagatgcat caacagactt gagtcgatca atgagggagt 2226481 gcttacagta aacggcaccg ccattaacga cagaaaaact gatatcaatc aagtgcggca 2226541 aaatatcggg atggtgtttc agcactttca tttatatccg cataaaacag tgctgcagaa 2226601 catcatgctg gctccggtaa aagtgcttag acaatcacct gaacaagcaa aggaaacggc 2226661 gcggtactat cttgaaaaag tcggcatccc agacaaggct gacgcctatc cttcccagct 2226721 ttccggcggg cagcagcagc gtgttgccat cgcaagagga ctggcgatga agccggaggt 2226781 catgctgttt gacgagccga catcagcact tgatcctgaa atgatcggtg aggtgctaga 2226841 tgtcatgaaa acactcgcca aagaaggcat gacaatggtt gtcgtgacac acgaaatggg 2226901 gtttgccaaa gaagttgccg accggattgt cttcattgac gaaggaaaaa ttttagaaga 2226961 agcagtgccg gctgaatttt acgcgaaccc gaaggaagaa cgggcccgct tattcttaag 2227021 ccgtatttta aatcattaaa acagaaatgg gggagcttgt atgaaaaaga ttttttcttt 2227081 agcattgatt tctttattcg ctgtcatctt gcttgccgct tgcggcagca agggatcaaa 2227141 cggagaagcc tcaaaggaga gcaaaaaaga tacgctagcc gccattaaag acaatgacaa 2227201 aattgtcttc ggcgtaaaaa cggacactcg actgttcggt cttaaaaatc caagctcagg 2227261 tgagattgag ggttttgata ttgatattgc taaacaaatc gctaaagaca ttttaggtga 2227321 tgagaaaaaa gctcaattta aagaggtcac ctcaaaaaca aggattccta tgctgcaaaa 2227381 cggggatatc gacgccattg tcgccacaat gacgatcact gaagaacgaa aaaaggaagt 2227441 tgacttttct gatgtctatt tcgaggccgg gcaatcgctt ctcgtgaaaa aaggcagcaa 2227501 aatcaagagt gtcgagaatc ttggcaaagg ctcaaaagtt cttgcagtaa aaggctccac 2227561 ctcctctcaa aacattcgtg aaaaggcgcc tgaagcatct gttttagaat ttgaaaacta 2227621 cgcagaagcc tttacagccc ttaaatcggg gcaaggcgat gccctcacca cagataatgc 2227681 aattttatat ggaatggctg atgaaaataa aaattatcaa ttaacaggaa agccttttac 2227741 agatgagcct tacgggatcg ccgtgaaaaa agggcaatct gctctcgcga aagaaatcaa 2227801 cgcttcactt aaaaagatga agtcggatgg cagatacgat gaaatttata aaaaatggat 2227861 caaagaagac ccagctgaat aacaaccatc ccgggatgag caggcgatgc tcatcccaat 2227921 ttgataagga gtgaataggc agatgaatgt gtcaattctt ttcgataact tcagcatgta 2227981 tatggacggt ttttaccata ccttgctcgc aagtgttatc gcgctggccg gcagttttgt 2228041 cctcggcgtt gctgtagcgg ttatgagaat aacagtcttt aagccgctgc aatggctcgg 2228101 gaccgcatat gtagaattca tccgcaacat ccctcttctt ttaattacct ttgttttcta 2228161 tttcggactt ccaaacgcag gcctgaggct tgacggtttt caagcgggaa cggttgctct 2228221 caccatttat acctctgcgt ttatcgctga agccatcaga gcaggcatcc agtctgtttc 2228281 aaaagggcag atggaagcgg cacgctcgtc aggctttacc tacagccaag ccatgctcca 2228341 tatcattttg ccgcaggcaa tcaaaatcgt cattccgcct ttaggcaatc aatttttaaa 2228401 cttagtcaaa aactcttcga ttcttggggt tgtggccgga ttggatctta tgtaccaagc 2228461 cgatttagtt tcgtcgagca cactcgttgt atttgatgtt tatatttttg tggcgctttt 2228521 ttacttagtg ctgacgattc cgcttagcat cggtgttaac tatctggaaa aacggctgga 2228581 aaaaagctat tgataaggag tgagttacat tggatttcat cggtgcttat tcacaggagc 2228641 atttagcgtt tttatgggat ggctttctcg tcaccttgta cgttgctttc atctccatca 2228701 ttctgagctt tttcttcggt ttaatcgcag gcaccctgcg ttatgcgaaa gttcccgttc 2228761 tttctcaatt gattgcagtt ctcgttgaaa cgatcagaaa cctccccttg ctgttaatta 2228821 ttttctttac gttttttgcc cttccggaaa ttgggattaa gcttgaaatt acagctgctg 2228881 caattacagc actaacgatt tttgaatccg ctatgctatc tgaaattatc cgaagcggac 2228941 tgaaatcaat tgacaaagga caaattgaag cggcgcgctc ctccgggctg agctatacac 2229001 agaccctgtt ctttatcgtt atgccgcaag cgcttcgccg catggttccg cccatcgtaa 2229061 gccagtttat ttctttatta aaagatacat cgctcgctgt tgtgatcgcc ctgcctgaac 2229121 tgattcacaa cgcgcaaatt attaacggcc aaagcgctga cggcagttat tttttcccga 2229181 tctttttact tgcggccctt atgtatttcg cagtcaacta cagcctttca ctcgcagcaa 2229241 gacgcctcga ggtccggcaa acatagaaaa ggatactctt tggagagtat cctttttgca 2229301 ttaaaacatt ttcgtaattc ttcttctcat ccgcttcatg cttcgattat tcagcatgtc 2229361 agattgagtc gccattcggt acacgagagc tccggctccc attgccaaaa gagaagtcat 2229421 cgtccgattc atcctgcgca tctcctttca tgattaaaaa ttgatgctgc gttcatcctc 2229481 agaaaacaaa tcatccaagc tgcttaacgt tccgtcttct tccacctgat gagttgcaat 2229541 cttccctttc gccactgtca gttcaataaa acagccccag caataatatt ggttcacgcc 2229601 gattttgccg atatccttac ttttgcaatt cgggcatata agcatacctc acacctctat 2229661 ccgttcagaa cgatctcgtc tttccgcacc tcgacaagcg aatccgctct ttggatctgg 2229721 cgcttgcttc ccgccaggtc agaaaagaaa ccgtccgaga gttcatatgc tacgattatg 2229781 cccctgtcca aacaaaagta tacatcttcc agcatcccca atatatcccc ctcttgcgat 2229841 ttcacaagct tcatcttcat ctgctcgtat gtgaagcatg atttcggaag aggcaaaagc 2229901 tgttctgaac tgaccgaagc caatatgcgg tcatcaaaaa tggaagagat atcacacgcc 2229961 cgtaatagcg catgatgatg atgcaaaaag cgtttttgtg caagaataaa cccaagacaa 2230021 tctcctttca gagaaaaaca aatatcggaa attgtcccga gataactaga agttcgttct 2230081 gagtatactg ggaatccttc tacttcatgg catgttctca aagtgtgatc aaccaccttt 2230141 tgttgaacag gcttaggttt tgctttgcgc cttagactca tacgatgaaa tcaattccac 2230201 tgcaaatgaa aaaaaactcc cgcttgcacg ggagcatttt attgctgttc ttctttcata 2230261 aaatcgaatg gtgtaatgcc ttccatgcca atgttggcgt cgtgtacgct gaacgggagc 2230321 tctttttgca aagcttcaag ctcggcatcc atttcctcaa cctgtacgga cagcctgttt 2230381 ttcaaggagg tctgtctgac agttgcatca ttatttttca cgccccactc cagcgcctcc 2230441 tcttccccgc ataaaatgag aaatttcttc gctcttgtaa tcgcggtata aagaaggttt 2230501 cttctgagca ttctataata gcctttcaca acaggcaaaa ccacaatcgg aaattcactt 2230561 ccctgcgatt tatgaataga acagcaatac gcatgggtaa attgattaaa atcttttttc 2230621 gtaaatgtca tttcattgcc gtcaaaagaa acgacggcca tgtcttcttt ttctgtattt 2230681 tcctttgcat aaaatatcga cgtgatttcg ccaatatctc cgttgaacac attgttttcc 2230741 ggctgattga caagctgcaa aattttatct ccggttctgt agacaacatc cccgaacttc 2230801 aattctctcc gtttttcttt aggaggattt aaaatgtcct gcagcatcac attcaattca 2230861 ttaatgccgg cttttcctct gtacatcgga gcgaggacct gaatgtcctt tgctgtatag 2230921 ccttttttca atgcattggc gacaaccttc tcaactactt ctttgatttg cgacccgccg 2230981 cagcgaataa aggaacggtc ctttgtcggg gcagtcaaat tgttcggcag caatccattt 2231041 ttcatctggt gggcaagctc gacgattgat gacccttctg cctggcgata gatgtctgtc 2231101 agtctcacag tcggaatcac ctgggatgcc agcaggtctc tgagcacttg tcccggaccg 2231161 acggaaggca gctggtcttc gtctccgaca atgatgattt gtatatgatc agggatcgcc 2231221 ttgaacaaat gattcgccag ccatatatca agcatactgg cttcatcgat aattaacagc 2231281 ttcccttcga tcggctgatc ctctgtatga gtaaagcctt cagcgccgtt ccagccaagc 2231341 agcctgtgta tcgtaactgc agggagtccc gttgattcac tcatccgttt tgctgctctc 2231401 cctgtcggag cggccaaaac aatcggaaaa gcttcatcct ttttataagc tgacgggtct 2231461 agtgacacac cgtgaagctc tccgtagagc tcgacaatcc ctctgattac cgtcgttttt 2231521 cctgttcccg ggccgcctgt taaaagaagc atcggcgagg aaagggcttt ttgaatcgct 2231581 tccttctggc tgggggcata ctgaacgtcc atccgttctt ccagttctcc caacgcgagc 2231641 aaaaactctg attcgggaaa ctggttctca tattcggttt ggctagcgat atgtttcaca 2231701 cgctttgcaa cgttttgttc tgcgtaaaac agcgaaggaa aataacagcg gccatcttct 2231761 atgacaatgt ctttattttc tccaagggca ataattgcgt tagcggcatc catttctgta 2231821 atgcgctgcc cttcccttgc tgactggttt aacagtgatt gagtgtcgat gatcagctgt 2231881 tccgtttcta tgtacgtgtg cccctctgac agacaagtcg tttcaagcgt gtacaaaata 2231941 gcagctttta cccgctcagg atgattaccc gaaagaccca ttctgctgcc cagctcatcc 2232001 gcttttccaa acccgatgcc ttctacatcc ttcacaagct gataaggatt ttcctgaatc 2232061 ttttcaagcg tctcggattc ataggcttga tagattttca tagacagctg cgggccaaag 2232121 ccaaactgat tcaaggaaat catgatttgc tccagtccct gatgccgctg caatgcgcca 2232181 gccagcgtgt ctgctttctt ttttgagagt ctgggaacat cataaagcac tgaagcatca 2232241 gccaatattt tattaatggc gctgtcgccc agctttttca caatttcttc agctgttttt 2232301 ttgccgatcc cctcgaataa atcactcgat aaatattgaa tgatgccttc cttagtcgtt 2232361 ggaatctcct ttttgaaatg ctccgcctga aattggagcc cgaattttgg atgggttacg 2232421 atctttccgt aaaacgtgta ggtctcttct tcttgaagcg cagggaagta gcccgtcacg 2232481 gatacggctt tatcttcaat ggcttcggag gtctctgtga ctttcacttt cagaaccgta 2232541 tataaattgg tgtcattatg atagatgact gtgttgactg tcccttttaa atagggctct 2232601 tcctccagtt taagctgatc cggatgctgc tgcacgagct gtccctcctc ctgtgcctgt 2232661 tatgatggat caatcagttt tttagcatga agcgcaagca tatgatctgg ctggatatcg 2232721 attgccttgt ccagcatttc cagcgctttt tctcggtttt ctttataagc ataagtgaca 2232781 ccggcattat aaaatgcatc tgcatgcccc gggtcttgct ctgtcacagc tgcgaattgg 2232841 ctgagcgctt cgtccagcat gccctcgttg gctaagcaca tcccgaattg aaaacgcgct 2232901 tccgtatcgt tttcattcag ttcgactgct ctttgtaaat atggcagtgc aagcttaggc 2232961 tgttcgagct tgacaagtac cgttccgagc atgtaaaaca ggtcgccgtt ttccatcccc 2233021 gcacgtagcg ctttttcaaa catgtctttc gcttctttgt acatttcttt tacaacatag 2233081 acatttcctg ctccataata agcagtggct gcgctactgt ctaattcaag cgctttatca 2233141 taaaacgcaa gcgcacgttc cagctcgttt acggatgaaa gaaggttggc aaaattgata 2233201 tacggaatcg cgtcttcttt attttcttca atcgcttttg taaatgcctc tgccgctttc 2233261 tcgtaatcgc cttcctgcat cgcctctata ccgagttgat tataatccac cgatcatctt 2233321 cctttcatta aaaaacccca actcagtgtt gaggtttttc atcttttata cgtaccacaa 2233381 ttttgttccg tctttgtaca catcatcaat tgtcccgccg ccaaggcatt cttcgccgtc 2233441 atagaagaca acggcttgtc ccggcgttac agcgcggact tgttcatcaa agatgacttc 2233501 cgcttcacct tcgccagtca tgcgcactgt tactttatga tcctcttggc ggtaacggaa 2233561 tttagccgtg caggaaatct cttcgccctt catgatatcc gaacgtaccc agctgatatt 2233621 tgttgctgtg attttgtcgg aatataaaag cgggttatgg aacccttgat ctacgtagag 2233681 gatgttcttt tcaagatctt tgcctaccgc aaaccacggc tcgccgcttc cgccgatgcc 2233741 aaggccgtga cgctgtccga tcgtatagta catcaacccg tcgtggcggc cttttacttc 2233801 gccgtccatc gtcatcatat cgcccggctg tgcagggaga tattggctga gaaacgtttt 2233861 gaagttgcgt tcgccgataa agcagatgcc tgtactgtct tttttcgtcg ctgttgcaag 2233921 ttctgcttct ttggcaattt cacgcacacg gcttttttga agttcgccga tcgggaacat 2233981 gactttgctc agcgtatctt ctgtcagctg attcaggaag tacgtttgat ccttgttttc 2234041 atcaatgccg cgcagcattc tgacttttcc gccgcttctg tctactcttg catagtggcc 2234101 agtcgctaaa tagtcggcgc caagtgacaa tgcatgctcc aaaaaggcct tgaatttaat 2234161 ttctttgttg cacaatacat ccgggtttgg tgttctgcct gctttatatt catcaaggaa 2234221 gtattgaaat accttctcat aatattgctt ttcaaagttt acggcataat acggaattcc 2234281 gatttggttg cagacgcgga tcacatcttc ataatcctct gtcgccgtgc aaaaaccgtt 2234341 ttcgtccgta tcatcccagt ttttcataaa gattccgatt acatcatagc cctgttcttt 2234401 taacagcagg gccgccacag atgagtctac tccgccggac atgccgacga cgactcttgt 2234461 atcctccggc cgtttttcca tttcattcac tccaattact acgccgcctt attatgtcag 2234521 ccgtttgaca acgtcggcca catgtttggc agcagttttc acttgctcag ccgtattgcc 2234581 gaggccgaag ctgattcgaa tagaggacgt cagccggtca ctctcttcgc cgaacatagc 2234641 agtcagaaca tgtgacggca ggactgaacc ggccgtgcac gctgaaccgc tggagacagc 2234701 gacaccagcc atatcaagat taaccagcag cgcttccact gacacaccgg ggaaataaag 2234761 attcagaaca tgcggcagac tatgctcttt gtccccgttg acctcgaatg ccacacctgc 2234821 atctctaagc gtgtcggcaa agattgcttt aaacgattga tacttctcgt ttttttcgtc 2234881 acgttcttca cttgacagct tgatcgcttc tttcagcccg acaatgcctg gaacattttc 2234941 cgttccggca cggcgttttc tttcttgctc tcctccgaat aaaaggggtg aaagcttcac 2235001 atctttacta gcatataaaa agcctgtccc ttttggcccg ttgagcttgt gcccggaaac 2235061 agacagaagg tcaatatggc tgtttttcac atcaattggc agcaacccga atgcctgaac 2235121 agcatcggta tgaaaataag ctttgtgttc ctttaacagc tcaccgattt cttcgatcgg 2235181 ctgcactgtt ccgacttcat tatttccata catcactgtc acaaggattg tatcatcacg 2235241 cagtgcttct ttcacctgtt ttgcactgac tcttccattt tggtcaacgt ccagatacgt 2235301 tatgtcaaat ccgtctccct caagtttttc acatgtgtga agcacggcgt gatgctcaat 2235361 ttttgttgtg atgatatgtc tgccaagatc ttttcttgca agtgcggttc ccatgatcgc 2235421 caagttatca gcttccgttc ccccgcttgt aaaaatgatc tcctgctctg ccgctccgat 2235481 ttctgctgcg atctgcgctc ttgcttcatc cacccatttt cgagattctc tgccaaatga 2235541 atgaatactg gagggattac cgaaactgcc ggagaagtgc ggtatcattt gttccagcac 2235601 gcgctcatcc atcggagacg ttgcggcatg atctaaataa atccgttcca ttatgtttac 2235661 acctctgatc taaatataga acatataagc ttcttgctct ccgtctgtat agctggcaag 2235721 atcctctaat gttgtactgt ctaaaacctc ttttacagca tcccggatgc gaatccagag 2235781 ctcacgcttg gcaggctcct catcttccag cacttcaaca gggctgatcg gcccctcaag 2235841 cacacggata atatctcccg cagtaatggc atccggctca ctgcctaata catatccgcc 2235901 atatgcgcct ctgatgcttt tcactaaacc ggcatttctg agcggcgata ccagctgctc 2235961 caaataatgc tcggacaaat tattcgtctg tgcgatgctt tttaatgaag tcgggccttc 2236021 accgtgcttt tttgcaagct cgatcataat ggtgagcccg tatcttccct tagttgatat 2236081 tttcaacatg aacacctctg ttatttcatg attttccaca tttataatgg taatttctat 2236141 atgtttcgtc cgtttattat cttatagacc aactgttatt ataacatacc ttcagcgaat 2236201 tttcattgag gcagaaggaa aggggccttt acccttttct aatgtacggt tttccgttac 2236261 cctgtaatta agtaaggaga gatgatagat gaagccattg gcatatcgga tgcgtccgac 2236321 aaaaatagag gatattatcg gccagcagca tctggtggct gaagataaaa ttattggcag 2236381 aatggtccag gcaaaacatt tgtcatccat gattttgtac gggccgcccg gaattggaaa 2236441 aacatcaatc gcaacagcaa tcgccggttc aacaagtatt gcttttcgaa agctgaatgc 2236501 tgtcattaac aataaaaaag atatggaaat cgtagctcag gaagccaaga tgtccggcca 2236561 agtgattttg attctggatg aagtccacag gctggataaa ggaaaacagg attttctatt 2236621 accctattta gaaaacggaa tgatcatttt gatcggagca acgacggcta acccgtatca 2236681 tgccattaat ccggcgatca gaagccggac ccagattttt gagcttgaac cgttaacacc 2236741 tgaactgatt aaacaggcac tggaacgtgc gctccatgat gagcatcggg gccttggcac 2236801 ctattctgta tccattgatg atcaggcgat ggagcatttt gcccacggat gcggaggaga 2236861 tgtccgctcc gctttaaatg cgcttgagct tgccgtgttg tcaacgaagg agtcagcaga 2236921 cggtgaaatt cacattacat tagaaaccgc ggaagaatgc ttgcagaaaa aaagcttttc 2236981 tcacgataaa gatggtgacg cgcattatga tgtactgtcc gcttttcaaa aatcaatccg 2237041 cggctctgat gccaacgctg ctcttcacta tttggctaga ttaattgaag ccggtgatct 2237101 ggagagcatc gcaagacgat tgcttgttat cgcctatgag gatatcggtt tagcaagccc 2237161 gcaagccggc cctagagtgc tgaacgctat tcagaccgct gagcgagtcg ggtttcctga 2237221 agcgcgaatc ccgctggcca acgcagttat tgagctttgc ctctcaccga aatcaaactc 2237281 tgccattctg gcaatcgatg aggccctggc agatatcaga gccggaaaaa ttggggatgt 2237341 cccgaagcat ttaaaagacg cgcattataa aggagctcag gaattaggaa gaggaatcga 2237401 ctataaatac ccgcacaatt acgacaacgg ttgggtcgaa caacaatacc tccctgatcc 2237461 tctgaaaaat aagcaatact ataagccgaa acagactgga aagttcgaat ctgccttaaa 2237521 gcaggtgtac gataaattaa tgaaaagaaa ataaaacaaa aaaacagcct tgatcatcaa 2237581 ggctgttttt atgcattatt tatccttcac acgtttgatt tcaatgtctt tcaaaagatc 2237641 catgacaaca tgtccgccca taatcaaacc tgcaactgac ggcacaaaag cattagagga 2237701 aggcggcatt tttgctttac gtattttcgc ttcgtcattc cccacttctt ttctgacatc 2237761 ttcccgaata acaatcgggc tttcatcaga gaaaatcact tgaacgcctt ttttgatacc 2237821 ctccttgcgt aatttcgtac gaacgacctt cgcaattgga tcagtgtgcg tttttgagat 2237881 atcagcgatt tggaagcgtg tcggatccgt tttatttgca gcacccatgc tggagatgag 2237941 cggaatatcc cgttttagac attctttcat taaatgaatt ttataacaaa tggtgtctga 2238001 cgcatcaatg acatagtcaa gaccatagtc aaaaaactgc tcatacgttt cctccgtata 2238061 gaacattttt aacgcgatca cttcacactc cgggttaatg tctgcgatcc gcgccttcat 2238121 taaatcaact ttcggctgtc cgacagttga aagcagcgcg tgaagctgac gatttacatt 2238181 tgtaatgtcg acatcatctt tgtcgacaag cagaatgcgg ccgacgcctg accgcgcgag 2238241 agcttccgcc gcgaacgacc cgactccccc gactccaagc acagcaactg tgctgttttt 2238301 cagcgtttca aggccttctt ttccgatagc taattcattg cgtgaaaact ggtgtaacaa 2238361 gaacctcact ccacattcgt attctggttt catctataaa atggctgatc catgagcagc 2238421 cgttttttct gcgcacaaaa aataaagtcc caatagtgcc gttgcagctt tcctttgttt 2238481 tgaacccgct ctcagcaggt gggtgccctc ttttaaatct tgtaagtcct ctttaccgaa 2238541 tgaaaagagg catgtacgcc atttaaaaat gcgggctccc aaatcaaaaa aatgttcggt 2238601 caaaactagg tgtacaacta acacatcagg actttattta acttgtcaaa atcatatcac 2238661 agacgatttt gattttcaag aatcgaactg caaattcagt tcttaacttt tttcttgata 2238721 gaaagatgaa gctcgtcaag ctgggcgtcg cttacttcgc ctggcgcttc tgtcatcagg 2238781 cagcttgcac ttgccgtttt cgggaatgca atcgtatctc tcaggttcgt acgtccagcg 2238841 agaagcataa cgagacggtc taagccgagt gcgattccgc cgtgcggagg agcgccgtat 2238901 tcaaatgctt ccagcaggaa tccgaactgt tcagccgctt cttctggtga gaagccgaga 2238961 agcgcaaaca ttttttcctg aatatccttt tcgaaaatac ggattgaacc gccgccaagc 2239021 tcatagccgt ttaagacgag gtcataagct tgcgctttca tgtcttcagg cgctgtttca 2239081 atcagctcaa ggtcttctcg gacaggcatt gtgaacggat ggtgcgctgc gtaaaaacgg 2239141 ccttcttccg gatcatgctc taatagcggc cagtcgatga cccataagaa attgaacaat 2239201 ttttcgtcaa tcagtccgcg ttctttccca agctttaagc gcagggcgcc gagtgatgcg 2239261 gccacaactt cgaattgatc cgctccgaac agcagcaaat caccttcagc agcatcaagt 2239321 gcttcaatca gcttagactg cttttcttca tcaaagaatt tagcgatcgg gcctttcact 2239381 ccgtctgcct caaccttcac ccaggcaagc ccttttgccc cgtagtttgc agcaaaagcg 2239441 ccaagagcgt cgatgtcttt tctggagtaa tcgccggcac cgccttttac attgatggct 2239501 ttgaccacgc cgccgtttgc tacagctgat gagaacactt taaattccgt atcctttaca 2239561 atgtcagaca catccgtcaa aagcatgtca aaacgcgtat ccggtttatc agacccgtac 2239621 ttgttcattg cttcgtcata cgtcattcga ggaagaggaa gctgaagttc ctcacctttt 2239681 gtttcacgca taacctttgc catcatctcc tcagccaatg acataatgtc ttcctggctc 2239741 ataaaggaca tttcaatatc aatttgcgta aactcaggct gacggtccgc acgcaagtct 2239801 tcatcgcgga aacagcgggc aatttgataa tatcgttcaa tgcctgatac catcagaagc 2239861 tgtttaaata gctgcggaga ctgcggcagc gcgtagaact caccttcgtg cacacggctc 2239921 ggcaccaagt agtcacgtgc gccttcaggc gtgcttcctg ttaaaatcgg cgtttcaata 2239981 tcaagaaacc cattttcatc taaaaagctg cgaacagctt tcgtcacgtt atggcgcagc 2240041 tgcatcgtct ggaacatagc cggtctgcgc aaatctaagt aacggtgttt taaacgaacg 2240101 tcctctgaca cttcttcagc ttgatcagaa atcgcaaatg gaggtgtctt tgcagcattt 2240161 aatacgttca ctccatcagc atgtatttcg atcgcgcctg ttttcaaatt cggattaact 2240221 gttccctctt cacgcgccac cacttttcct tgaatatcaa gcacgtattc atttctgatg 2240281 ccttccgcaa tagcaagcgc ttcttttgac acatcagggt taaaaacgac ttgaacaatg 2240341 cccgtacggt cacgcaagtc aataaaaatc aatccgccga ggtctcgtct tttttggacc 2240401 cagcctttca gcgttacaga ttcgccaatt gctttttcag ttatatcacc gcaataatat 2240461 gttcttccaa acaatgcgtt tcactcctta tcccttttgg tttgccttca tcacatgtat 2240521 aaattcatca agtgccactt caatctgttc gcccgtctgt gcatccttta cattgatttt 2240581 gttttgggca agctcatctt cacccaaaat cgcaataaat ctggccttta agcgatcagc 2240641 tgttttaaac tggcctttca ttttcttatt ttcataatcg atttcactgg aaatgcctgc 2240701 ttctctcagt ttgtacacca atgaaacaga ataatccttt gctttttcgc cgagtgtgac 2240761 gatatagcag tcgattccct tatcaacagg cagctctctt ttttcagcat caattgcggc 2240821 aagcaagcgt tcgatgctca tcgcaaatcc gatgcccggt gcttcaggtc cgccgatctg 2240881 ttcgacaagc ccgtcgtagc gtccgccgcc ggcaagtgtc gtaatcgcgc caaagccctc 2240941 cgcattgctc ataatttcaa atgcggtgtg gttgtaataa tccagccctc tcacaaggtt 2241001 cggatcgatt tcatacgaaa tgccaagatc atttaagtat tgtttcactt tttcaaaata 2241061 agcggctgat tcttcattta aatatgtcaa aatcgaaggt gccgatttca tcagctcatg 2241121 atcacggtct tttttgcagt ccaaaattct aagcgggttc gtgtgcagcc gggactggca 2241181 gtctgaacaa aattcttcga tgcgaggctc gaagtgtttc acgagcgctt ctctgtagct 2241241 tttgcggcta tcttgatcgc cgagactgtt tatgacaagc ttaacgtttt ctaaacctgc 2241301 tttttcataa atactcatcg caagcgccat tacttcagcg tcgattgcag ggtctttcga 2241361 accaatcgct tcaattccaa actgataaaa ctggcggtaa cggcccgtct gaggacgttc 2241421 ataacggaac atcggcccga cataataaag ctttgtcggc tgtacaggat ttgcgaacag 2241481 cttgttttca ttaaaagcgc gaaccgcagc agctgttccc tccggacgaa gcgtcaggct 2241541 tctgcctttg cggtcctcga aggtatacat ttctttttgt acgatatccg ttgattctcc 2241601 gacgcctctg gcaaacagtt ctgtatgctc aaaaatcggt gtgcggattt ctttatattg 2241661 ataagtgcgg caagtgtctc tcataatttg ttcaacaaac tgccagcgat ctgattctcc 2241721 aggcagaata tcctgtgttc ctctcggaat gttatatccc ataggtagac ctccttatgt 2241781 attccttata aaatatccaa tgatcgttaa tgatgaaaat gaaaaaaact cccgccccta 2241841 ctatacatga tagtagggac gagagttata cccgtggtgc caccctagtt ggaatacgtt 2241901 catattcccg ctcgatcctt taacgcaggt tcacgttcac tgcctaatgg cgttattcac 2241961 gcgttcagca ggaaacctcc ggagtgttgt ttcgagaaag acgcaatggg atccgctttc 2242021 agcctggggc gggttcctct ctaatcatgc aatctgacct actcttctcc attattggtt 2242081 caaatctttc atcatttgct atgtactcaa tttctattat aataatggga ttggggttct 2242141 ctgtcaagct ttattccggt tgtttttcct cagcgctgct tctttggaca taagaccaaa 2242201 ttcagatgct gtttccgtaa gataaccagt cgtatcggga tctgcgtgat cgctgtaatg 2242261 cagattcgct tcaccgtcgt gaaatgcacg tcccattttt ggatgatatt tcatgatttg 2242321 cacacctttt tgattgtatt tacgcttagt ataaacaaat cattttattt ttatttaaaa 2242381 atcagaaagg actttacgat attaaacaag aatgcttttt taatgatcat cagaaaggag 2242441 gacacaatga acaagaaata ctttgtcctt attgtatgta ttattttcac ctcagcgcta 2242501 ttcccgacct tttcatccgt tacagctgct caaggagaag cggtcatcgc aacagatgaa 2242561 atgaacgtca gaagcggccc agggcttagc tacggcatta cagcggaagt aaaaaaggga 2242621 gaacgctatc caattttaaa ggaagatgga gactgggtgc agatacagct tggttctgga 2242681 gaaaagggct gggtagtctc ctggcttatt acaaaggaag accaggccag cacaagctcc 2242741 tcaggaagca gtgacactgt gacatcaaca gaccccgatc tgcggatgag aagcggcccg 2242801 ggcacttcct acgaagtcat cggcaaattc ccgcaaggca gccaagcatc tgtcattgat 2242861 aaagattcgg gctggatcaa gatatcctat cacagtgcca ccggatgggt atcatctgaa 2242921 tatgtcacat caggaggcag cagttcagcg tctgatgaga gtgaccaaac cgaggattcc 2242981 ggtgcgtcaa cgacgggcac agtcggtgtt tcttcgctaa atgtaagagc ctccgcctca 2243041 catgacgcgg caattataac aaaacttgat cgcggaacga aactgacggt tctcaacgag 2243101 aaaaatggct gggctcacat tgaggtgaac gggctaaaag gctgggttgc aagccattac 2243161 cttttgacta gttctgttcc agctgatgat tcagcaaatg ccggcagttc atcctccgct 2243221 aaaaaagcct atatcatgta cggaggaacg aatctaagaa gtgatgcgtc aacatcagct 2243281 tcgatcgttg agcgcgctgc caaaggagat tcatacacca ttaccggttc aaagggaagc 2243341 tggtatgaaa taaagcttga taacgggcag actgcttatg tagccaattg ggtggtccaa 2243401 acgtctaaaa gcgcagaaga agcaggtgaa ccgccagtct ctgattcccc gtctggaaac 2243461 ggctctctaa acaataaaac gattattgtt gacccgggac atggaggaaa agacagcgga 2243521 acgatcgggt attcggggaa attcgagaaa aacctgacga tcaaaacggc aaaactgctc 2243581 gccagcaaac ttagatcggc tggagcggat gtatatgtga cacgccagga tgataccttt 2243641 gtcagcctgc agtcacgggt ctctacctct cactaccgta acgctgacgc ctttatcagc 2243701 attcattatg acagctatgc ggatacctct acaagaggca gtacagcata ttactacagt 2243761 cctgccaaag atcaggaact cgcatcagat gtccactcag aagtggtgaa gcgttcttcc 2243821 attccagacc gcggcgtatt attcggagat tattatgtgc tccgggaaaa cagacagccc 2243881 gctatgctgt acgagctggg atatgtaagc catccgcagg aagaagccat tgtacatagc 2243941 aattcatacc aagaaaaagt aacagatggg atcgaaagcg gattagagaa atacttccaa 2244001 taaaaaaagc tgccttttgg cagctttttt tattttgaat ccataatgag cgtgaccggt 2244061 ccggagtttg taagctgaac atccatcatt gctccaaacg ttccggtctc cactttgatt 2244121 cctttttcac gaagcaggtc attccatttt tcataaagac ctaaagcttt atcaggtttg 2244181 gccgcgttca tgtagttcgg ccggcgccct tttttcgtat ctccataaag cgtaaactgt 2244241 gagacggata aaatctctcc tcctatatct acaagagaca gattcatttt cccttcactg 2244301 tcatcgaaaa tacggagatt gacaacttta tcggctaaat aagctgcatc atcttctgta 2244361 tcatcgtgag tgatgccgac cagcaccata aggccttgtc caatttggcc gacgacctct 2244421 tcgtccactg taacgcttgc ttctgttact cgctgaacaa ctaatctctt ttctaacccc 2244481 tttagttcat gacgcggcgc acagaataga tatctctaat ctgtttaata cgctcgacga 2244541 ctttatgcaa gtgattgata ttctggataa aaatcgccat atggatggtt gccactttat 2244601 tgcgatccga tttgccagag acagatgaaa tattggtttt cgtttcattc actgcctgga 2244661 gtacctcgtt cagcaatccg cggcggtcat acccaagaat ctctatctca acattgtatt 2244721 ccttgcgctt ttgaacttgt gactcatgtt cccactctac cgggatcagc cgctcttggg 2244781 cttcattcgt tttgacattc ggacagtctt cgcgatggac cgaaacccct ctgccttttg 2244841 tgataaagcc gacaatatca tcacctggca caggattgca gcattttgat aaacggacaa 2244901 ggaggttgtc aatgcccttg acacgaacgc cagcttcccg ttttcttcct tgcgggtatg 2244961 gcttaggttc cccagtgact tcctgaacga tcttttcctg ttcttcctgg tcgcgctgct 2245021 ttctctcttt ttctgttagg cggttcgcca cctgcagagc tgtgatgccg ttgtaaccga 2245081 ccgccgcgta catatcctct tcatttgaga aattaaattt gtcagcaacc ttttgaatat 2245141 tctccggcgt taaaacatcc ttcaattcaa aatccaagtt tttaatttct ttttcgacca 2245201 gctcacggcc tttttcgaca ttttcttcac gccgctgttt cttaaagaat tgacggattt 2245261 tatgcttcgc ttgggatgtt tgggcaagct tcacccaatc ctggctcgga ccgtaggaat 2245321 gcttagaggt gagaatttca acgatatcac ctgtccgaag cttatggtca agcgtaacca 2245381 tttttccgtt tactttggca ccgattgttt tattgccgat ttcagagtga atccggtaag 2245441 aaaagtcaat cggaacagaa ccggacggaa gctcgattac atctcctttt ggcgtaaaga 2245501 catacaccat gtcagagaac aaatcaattt tgagcgattc cataaattct tctgcatctg 2245561 tcgattcatt ttgaaattct aaaatttcac ggaaccaaga aagctttttc tcaaaggttg 2245621 caccttcatt ggctgctttc ccttctttat aagcccagtg agccgcaacc ccgtattccg 2245681 ctatttcatg catttcaaag gtgcggatct gcacttcaag cggatcgcct ttaggcccaa 2245741 taaccgttgt atgaagcgat tgatacatat tcggcttcgg cattgcgata taatctttga 2245801 atctgcctgg catcggtttc cagcatgtgt gaatgatgcc aagcaccgcg tagcagtcct 2245861 ttatgctatt cacaagaata cggacagcca acaaatcgta aatttcattg aattgcttat 2245921 tttgcagcac catttttcga taaatgctgt aaatatgttt cgggcgtccc gagaagtcag 2245981 ccttgatatt tacttcttcg acacgtttct tcacttcatt gacaacctca tcgacataaa 2246041 gctctcgttc tgcacgtttc ttcttcatga ggttgacaat tctgtaatat tgctgagggt 2246101 tcaaataacg gagcgccgta tcttccaatt cccacttaat ttttgaaatc ccgagacgat 2246161 gcgccaaagg agcaaaaatt tccagcgttt cattggagat tctccgctgt ttttcctgag 2246221 gcagatgttt cagtgtccgc atattgtgaa gacgatccgc cagcttgatc aatatgaccc 2246281 tgatatcttg agccatagcg acaaacattt tgcgatgatt ttccgcctgc tgttcctctt 2246341 gagatttata tttaattttg ccgagtttcg ttacgccgtc tacaagcatt gccacttctt 2246401 cggaaaatgc ttctttcagg tcatcgagcg tcacatctgt atcttccacg acatcgtgca 2246461 aaaatccgcc cgcgattgtg gaagggtcca tttcaagatc aacgagtatc cccgcaacct 2246521 gaatcggatg aataatatat ggctcgcccg atttgcggta ttgctcgcga tgagcatctt 2246581 cagcgtacag atatgctttt tcgacaaatg cgatatgctc atcagataga tagctgcgtg 2246641 ctttatctat aacttgctcg gcagtcaata cttgttcgtt cgccatggaa tcaccttttt 2246701 taaaatgtaa actgtattgt agtttattat caagaaaaaa acgaaagatg taaagagcag 2246761 aagttcaaat agccaaatat tatataaaat aaatgcaaaa caataggaaa aaagcaccct 2246821 gacatggagt gctttttcgt tatgcggtta tccttagtat ttcatcaatg ttaagatgtc 2246881 gtaatcttcg agcttatttc tgccgtcaag gtaagaaagc tcgattaaga aagcgatacc 2246941 agcaacaacg ccgccaagtt cttcaacaag tttgattgtc gcttcaattg tgccgcctgt 2247001 cgcaagcagg tcatctgtaa taagcacacg ctgaccaggc ttaatcgcat ctttgtggat 2247061 cgttaatacg tcttttccgt attccaagcc ataatccact ttgattactt cacgaggcaa 2247121 cttgccttct ttgcggaccg gcgcaaaacc tacgccaagc gcgtaagcaa cgggacagcc 2247181 gataataaag ccgcgcgctt cagggccaac gaccaaatca atttgctttt ctttcgcata 2247241 ttcaacaatt tgatctgtgg catagcggta tacatcgcct ttatccatca gtgtcgtaat 2247301 atctttaaat tgcacgccct ctttcgggta atccggtaca attgttacgt attgttttaa 2247361 atccatctgt tttatgtcct cctcgtactt tcataagcct ctgaatcttg tttcatcagc 2247421 ttattcagcc attccttcag ctcttcagca gaagaataat tcagcttttg atccagttcc 2247481 atcagctgct gtttcgcctg atatgtttgt gagtctgtta agtcgcgttt ctttgctccg 2247541 ctcacaacag acagcacacc attctctatt ttaacaaaac cgagatcaaa aaacaccttt 2247601 gtcatgaaat tgattgtttc aacggaccag cctttatgtt ttgcaagctc tgaaccgtgt 2247661 tttttcacgt caaaagcgcc tcttttcagc aagaacgcat aataccattt aaagtggtct 2247721 cttgcgggaa aagttgataa aaagtggtcc tcatgattga gaaaaataaa atatatccgc 2247781 tcgggcgcct ttccttccag caaacgtgcg agcatgtcca gcgaaggcgg cggatccagt 2247841 aatacaatat atgcaccatc gaggtcaaac gcctttgctt gatctttaga actgatgacg 2247901 tgcacttctc ggcgaaggtc ttcagtttga agtaatgttg ttgagtcttc tttgaaagag 2247961 acaatggccc gtttagcaga tggaagggcg gaaactgtgt cttcccacgt ccgttttccc 2248021 cttaaatcaa acagctgcca ttcagaaaca gcggcatcct ttatcataag ctgcggcttt 2248081 tttcgattgt tccattcgtt gattgacatc tcaccgacaa tggaaattct tgaacccggt 2248141 acgatgcctt cttgaagctc gcctttatta aaaccgacgc aatcaagctg ggacgactcg 2248201 tttctgatcg tcattttgac atgagtttta tttgccccta tcttgcggac atcttccagt 2248261 actgcatttt ctacgagaac gtgcggtttc gggttcagca tgccaaaagg agacagcatg 2248321 ttcatttctg cgatgctttc aactgtaatg tcttcgacgc cgcagacaag gtcgacttcc 2248381 tgtacgggaa taaaatcctc ttccgtaagc gtattgtccg ctatttcatt cagcctgctt 2248441 cgcaaatccg gcacatcttc ggctttcagc gtcatccccg cagccattgg atggccgccg 2248501 aaatgaggaa gaatatctct gcattcagaa aggctctcaa ataaattaaa tcctctgatg 2248561 cttcgggccg aacctttagc gattcccttt tcttcatcaa taccaagaac aatggccggt 2248621 cggtagaaac ggtccacaag ctttgaagcc acaatcccga cgactcccgg gttccatccg 2248681 gctttggcca cgacaattgc agtttgatcg agcccttgct gttcaaccat ttcaatcgct 2248741 tcatccgtca ttttgctgac cattttttgg cgctctttgt tcagctggtc aatttctgcg 2248801 gcaagctctt ccgcttcaaa cgaatcctct gacataagca aatgaacagc gggatccgcc 2248861 tgttcgattc ttccgacggc attcagcctt ggtgcgagct gaaatccgac tgtttcttcg 2248921 ttcgcttctc cgatgtctcc gcctgacagc ttaatcagct cttttaagcc gagccgattt 2248981 gtccgtcgaa gcctttcaag tcctagtgtt gctattaatc tgttttcgtc atgcagcggg 2249041 actagatcgg caatggtgcc gatagccgcc aggtcaagca gttcatcagg aagttcaccc 2249101 aataaagcgt gggcaagctt aaacgcgact ccaaccccgg caagctcttt aaacgggtaa 2249161 gtgcagccag gctgcttcgg gtggacgatc gcacggacat ccggaagctc cggtcccggt 2249221 tcatgatgat cggtaatgat gacatccagt ccgagttcct ttgccacctt cgcttcatgc 2249281 acagcggcaa ttcctgtatc aaccgtaatg atcaaagaga agccccgttc tttaatcgaa 2249341 cgaaacgcct gttcattagg tccatatcct tctttaaaac ggtcaggtat ataaaaatca 2249401 acttgagccg acagtttttg cagcgtgtga agcatcactg acgtacttgt aaccccatcg 2249461 gcgtcataat cgccatatat cataatcttt tcttgttgtg aaatcgcctg ttttattcga 2249521 tctgccgctt ctttcatgcc tttcatttca aaaggatcat aaaaatcggc atcctttgta 2249581 tgtaaaaaca gcctagcgct ttctgccgta tcaaagcctc tttttacaag cagggacgca 2249641 acaagaggtg ttatatgcaa ttgttctgtg agtgatttga ccttatcctg atctggtcgc 2249701 tggatttccc atcgcatttt tgacgctaac ataaattcac ccctcaacca ccctattata 2249761 ctagagcagg ctgaggggtt tcaaataata ttcgaaaact agtctttttt ctcaatcatg 2249821 gctgatgcat cctgtgtgtc agtctgatca gcaagatgag tatcctcttg tttatgtatt 2249881 gctgttctat tttctttccg caaggttttt atttcccgct tcaatttcat tacctgaaaa 2249941 atgccgacag aaaatacgat cagtgctccc attaaaactg agcccaaaat aacaagaatg 2250001 agcggccatt ctgatcttcc aaacaggtaa tcaacttcta cggatcgaac attaatgact 2250061 gcgaaaatag cgacaattaa ggtgaaaata agtgcgaaaa taatggtcca ttgtttattc 2250121 attctctttt cccccaaact tcttattgag gtaactttcc caatcaagac tggttttaaa 2250181 catggcttaa cactaggtta agctcccttt gctgttaatt tttcccggat cagcctcttc 2250241 agtccggttc cctcaccgga aatcacaagt gtatcgcctt cgtcaatgac tgtttcagag 2250301 ctcggattca gttgtttatc ctgattcttt ttaacaattg caatgaccgt cacatgatat 2250361 tcctgaccca cattcaaatc accaatcgtc tgatgaatgg caggcgctcc cgcctctgct 2250421 ttacaccact ctataatcaa atcatcaagg gctgactcga cctgttctaa tgctttcggt 2250481 ttatatgcca ttccgccaag aattgcagac atttgccttg cttcagcgtc atcaaactgc 2250541 acggaggcaa cacattcctc atggtcgttt tcgtcaaaat agtaaagctc tctccgtccg 2250601 tcatgatgaa tgataattga aattttatca cggtttctag taatcatttc aactttttgt 2250661 cctatgcccg gcagctctga ttcgcgaacc ctcatatata aaccctccta catatctgaa 2250721 aaccagccat aaacactttt aacaccatat atatgtttaa atgtaagcgt atgtcattat 2250781 agcaaatgtc tattttaagt tcaatgaaac ttcaaaaaac aggctgccct gcagaggaca 2250841 gcctgatatt ttttattgcg ccgaatcttt tttcagttct cttcctttcc atgcaagcca 2250901 aatttgtgcg gcaatgtata gagaagaata aacgcctgtt aacagcccga ccaataaagc 2250961 aattgagaag ttagtaatag aagatgctcc aaagatcagc aatgtcacaa caacaatcac 2251021 aacggttaat acagtgttaa ttgaacgtgt aaaggtttgc tgcaggctca ggtttacaat 2251081 atggttcaga tcggcaaagg ttttcggctt acgctttttc atatgctcgc ggaccctgtc 2251141 aaatgtaacg attgtatcgt taatggaata cccgattatc gtcaagatgg ccgcgatgaa 2251201 tgtaacatct acctcaagcc ttgtaatact gaagaacgtg acgataaaga atgcgtcata 2251261 tagcaatgag gcgatggcag caatcgccat tttgtattcg aatcggattg aaacgtaaat 2251321 aatgatgcca atagaagcta tagcaactgc gtacagcgca tttctcgcca gctccttacc 2251381 gactgtcggt gaaactgtgc tgacatttgg atcagatccg tatttgtctt taaaatacgt 2251441 ttttactttt gcaatggttt ctttatctgg caccccgaca aaacgggcaa caccgatatt 2251501 gctcttttcg cctgacagaa ctacagtatc agggtccata cccagagatt caaaatcctt 2251561 ctcaacttgc tctgtcgtca gcttatggtc gctttgcact tcaatccgtg caccgcttgc 2251621 aaagtcaatg ccaagattca gcctgaacac aagcaggata ataatcccgg caaccgtgac 2251681 cgcactggag aaaataaaga agtatttgcg tttgctcgtg aaatcccatt tttggaatgg 2251741 cgtatgcggc tctgtatttt catccgtatc ctgaatatcc atgatatgtt tcttattgac 2251801 accaaaccag ccttttttcc gatcaagcca tctgctttcc acaaggagag cgaggagaaa 2251861 tctcgataag aaaacggcag tgataaagct tgtcaaaatc gataggatca gcattgtcgc 2251921 aaacccttta acagagcttg tcccaaagat aaagagcaca accgctgcaa taatggttgt 2251981 aatattcgcg tcaaaaatcg tcgcaaatga ccgtctgttt cctgaacgga aggcagagcg 2252041 gactgacttt cctagcttga gctcttcttt aatccgctca taggtaataa tgttggcgtc 2252101 aacagccatc ccgacaccta aaatgagagc ggcaattccc ggaagcgtga gtacggcatt 2252161 catccagtca aagatctgga gtgtaatgta gatataaaca gacagcgtaa tcaccgcgat 2252221 taatcccggc agacggtaat agaaaagcat aaataagaaa ataattgcga taccgacaat 2252281 accggcaaac accgtatcat ggagagcctg ctggccgaat tgcgcgccta ctgatgtcga 2252341 atacttttca gtcagtttca caggaagtgc gcctgcgttt aaaatgctgg ctaaatcttt 2252401 cgcttcttga gctgtgaaat gaccttcaat ttttacatca gttgtattta gttcctgact 2252461 tacatttgga gcggatacaa atttaggatg ctctttttga acttctttct taaaggaatc 2252521 acctttatca taatccaacc aaatgacaag ctggttgttt ggcgccattt tcatgacctt 2252581 cttggtcact tcaccaaatt tatcagcgtc tttcagctta atcgtgacaa ttggctcatt 2252641 tgttgtgcta tcataagttt gtttagcgcc gttttcgact agatcagcac cgtttaacag 2252701 ttccttatca tttgcatctc tgaaagaaag ctgcgcttca gtcgccaaaa tttcacgcgc 2252761 tctgttttgg tttgtcacgc cagcgagctg aacgcgaatc cggttattcc cttcaatttg 2252821 gatgttcggt tcgctgacac cgagaacatt ggcccggcgg ttcagtgcct ctactgtgct 2252881 gaccagaacg tcttttgtga ttttgtcacc tttttttaca ggctgtacat catacagcac 2252941 ctcaaatccg ccttgcaaat ccaatcctaa cgtaatattg ttagcggcag gcttcgtaaa 2253001 gtagcccaag cccgtgccga tcaatagaac gaaaaggaaa aacgcaatca agcgtccttt 2253061 tttcattatg tatatcctcc cttaaacctg tgcgaatcaa cctgctatct cagcagttct 2253121 tccaatgctt cctggccctc ttcactgccc agccaattag acgttttaaa tgactcaacg 2253181 gttgcatagt tcataaattc gccaattttc actgataaaa tatcactcgc cagttcataa 2253241 atgctcagtt ccgttttctt tttccacttc ttatctgtta agtatgacca caaactttcg 2253301 agttcaacat catcataccc gagaatctta aactcttcca gtttgctgta aagaaacggc 2253361 ctgacgtggt ctttatatag atcggctgga tgcttctcca cgaattccac gctccttttt 2253421 tattgttttt caagaagact tgtcatgctt ggacgacata tacgcatatc tttattgtat 2253481 atgattccag gtagtttgag aaggcagggg gtaaaaatgg cgaaacagac gtttttaaag 2253541 ggcactctta tccttatcgc agcaggaatg gttacaagaa tgctcgggtt tgtcaaccgg 2253601 gtggttatcg cccgttttat cggtgaagaa ggagtcgggc tttacatgat ggcagcgcct 2253661 actttcttct tggccactac attaactcaa ttcggtctgc cggtcgcgat cagcaagcta 2253721 gtcgctgaag ccagtgcgcg cggagatcat caaaaaacga aaaatatttt agtcatgtct 2253781 ctgaccatta cgggagtgct cagcctcatc tttacaccgc tgtttctgtt tttcgcccct 2253841 gttatggctg aaacgatgct gacagataag cgaacactgt atccgctctt ggccattacg 2253901 cctgttgtgc cgattattgc tatatcgagt gtgctgaggg gatactttca aggaaaacag 2253961 aatatgaacc cgcttgctat gtcacaagtc cttgaacagg ttgtccgcat ttcactcgtg 2254021 gctgtctgca caacgatttt tctcccttac ggaattgaat atgctgcagc gggggcaatg 2254081 ctatcctcag tggcagggga gctggcatca cttctttatt tattcgtttg ctttaagtat 2254141 aaaaagacaa ttaaaatcag aaagcatttt ttacagtcaa ttaaaaacgg aaaacaaacc 2254201 tttacccaat taatgagcgt gtcccttcca acaaccggga gccgctttat cggaaacctc 2254261 tcttggtttt tcgagccaat cgtcgtcgct caaagccttg ccatcgccgg tgtggcaaca 2254321 gttgccgcaa caaagcaata cggggaacta accggctttg ccatgacgct gctgactctg 2254381 cccagcttta ttacatattc tttgtcgacc gcgcttgttc ctgcgatcag tgaaggaatg 2254441 gagcagaaaa aattgcaggt ggtggaatac cgcttagaac aggcgatgcg tctctgtctg 2254501 ctcagcggag gcatttcagt tgttatttta tttgtatttg cggatgagct gatgagagtg 2254561 atgtacggtt cctcaggcgc agctgtattt ataaaagtga tggccccgtt ttttctgctt 2254621 tattatttcc aaggcccgct tcaagctgtg ctgcaggcgc ttaatttggc aggagctgcg 2254681 atgatgaaca gcttaatcgg agcgcttgtc aaaacaggcc ttatttttgt ccttgccaca 2254741 aggccttctc ttggcattat gggcgcggca ttagccattg tgacaggcat ggtgctcgtc 2254801 acgctattgc acgcagcaac cgtaagcaaa gtgctgccga tcagcatcaa aatcaaggag 2254861 tacgcgctca gcttcgctgt tattgtaatt tgcggattca tcagctccgc catcaaacaa 2254921 tatataagct ttggagcatc tgaggctgtc aatctagccg gatggattgc ggcgagcgcc 2254981 gccatttata tgatcctcct gctcgttttc cgtttaatta aaaaagatga gcttcgccgc 2255041 attcccatta tcggacggtt gatcatccga taatggtcac gtgcggtgcc catctttttc 2255101 atcaatatat atttctccgt ctgtaaacga gcaaaatgaa atatctgaag ggtttgtgta 2255161 tccgtgtttt tgcaaacttt caagcagcca ttttctatct ttactgattc tggacaggtt 2255221 ttctgtttga atgaagccgt ctataatgag cggcatttcg agctgccgat gctctccgct 2255281 gttttctttc ttaacaatag tcagtttgcc cgacggctct aaaatagcaa atgatacgtc 2255341 agctactctg tcgatgctat tttctctgag ctgaaccatt aaatcatcaa aattataacg 2255401 ctgtgatttc atggcttctt cgtcaatttt tccatatttg ataattatgg tcggcttacc 2255461 gtcaagaagc tggcggactt ttcggttttt taaagaaaag tatgccaaag tcacttgaat 2255521 gatcattaat acaagcattg gcaaaatggt atgaaataga tgatcgtcta cgttttctat 2255581 ggctaaaacg gcaatttcag ccatcatgat aaagacaacg agatctaaaa tactaagctc 2255641 tccgatctcc cgtttgccca tgaaacgaaa aatgaccaat atcacaaaat acaatacgac 2255701 tgtgcgaaac gcaatagtga gaagctcttc cattatgcac ctccaactca ttataggttg 2255761 caacaaaatg atcaatttat gtaagaaaaa ccgattgcat ttcacaaagc ttttacgtct 2255821 aattcatggg ataagggaat acatttttac aaagacgagc catcagcatg tctgacggtt 2255881 ttgaacaaaa agaacagaag ccttttaata caggcagaga ggagacaatc atggaggaaa 2255941 cgaaacaagt tggaaaaggc attctttacg gcttaatcgc catattttca gccatgctcc 2256001 tgacaagttt agcggtttca cttttattga ccgcaacctc gctggaagaa tcatcattta 2256061 actggctgat caccgctatc tcatttctct ctttatttat cggcgggttc atttcaggcg 2256121 ggaaaggcaa ggaaagaggc tggatgattg gcgcattgac cgccttaagt ttttctctga 2256181 ttatcttatt gtttcagtat ttaggattcg gaaagacatt tacagcagaa cagctgatct 2256241 tccatctggg atttttaggg gtgtgcatgc tgggcgggat tttcggcgtg aacatgaggg 2256301 gaaacaggtc ttccacataa aaaagagcgg gctcacttgc ccgctctttt ttgtttgcta 2256361 tgtatagctc ctgctgttat tcagcagcag aaacttctct gatcgcgcgg cggtcgaacg 2256421 taagacgtgt gttatcacca gtcttaatta cgactttgct ttcgtcgata gagtcaacag 2256481 taccgtgcaa tcccccgatt gtcactactg aatcgccttt tttcagttcc tcttgcattt 2256541 ggcgtacagc cttttgctgc ttttgctgag gacgaatcag caagaagtaa aggaccgcaa 2256601 acattaaaat aataggaacc aatgtaccta aagtgccagt catcattttc acccctttct 2256661 gtaagcctgt tatgtttatt tagaagcttt tcgcatttgg cttgttatag ccgtaacgct 2256721 caaagaactc ttctctgaaa tcacccagac gatcctcgcg aatagcctgt cttacctgct 2256781 ccattaagtg taacagaaaa tgaaggttat ggtaagttgt taatcgaagg ccgaatgttt 2256841 cattgcagcg aatcaagtgc ctaatgtacg cgcgagtgta gtttttacat gtatagcaat 2256901 cacactcttc atcaatcgga cggaagtctc tttcaaattt cgcatttttc atattgagtc 2256961 gtccttcagc agtaaacact gtgccgtttc ttgcaatccg tgtaggcagc acacagtcaa 2257021 acatatcgac cccgcggatc gctccgtcga tcagtgcgtc cggagaacct actcccatca 2257081 gatatctcgg tttatccttc ggcaagagcg gtgttgtgaa ttcgagtaca cggttcatga 2257141 catccttcgg ttcacctaca gacaatccgc ctatagcata tcccggaaaa tcaagcgaaa 2257201 tcaagtcctt cgcactttgt gtccgcagat cttcatattc tccgccttgt acaataccaa 2257261 acagcccttg ttcatcctga cgattgtggg cattcaggca gcgttccgcc cagcggcttg 2257321 tccgttcaac tgacctcttc atgtagtcgt actccgccgg gtatggcggg cattcgtcaa 2257381 acgccatcat aatatcagag ccgagtgcgt tttggatctc catcgctttt tccggagata 2257441 aaaacagctt gtctccattt agatgattgc ggaaatggac accctcttcc tctatattac 2257501 gaaacttgct taaagaaaag acctgaaaac cgcctgaatc tgttaaaatt gcgcggtccc 2257561 agttcataaa tttatggagc ccgcccgctt ctttgacaat gtcttggccc ggacgaagcc 2257621 atagatgata agtgttgctc aaaatgatgc ctgcatccat tgctttcagc tcttcaggcg 2257681 acattgtttt gactgtcgcc agtgtgccga ccggcataaa aaccggcgtt tcgaaggagc 2257741 cgtgaggcgt atgcactttg cccagccgcg ctcctgtttg tttgcattct tttataaatt 2257801 catagcgtat tggttgttca gccacttttg atgaggcctc ctgttctcaa attatataat 2257861 cagcatcgcg tctccgaagc tgaagaaacg gtattcctct tccactgcat ggttataggc 2257921 acgcagaatg ttttctcttc cagcaagcgc gctgaccagc ataatcaatg acgatttcgg 2257981 caaatggaag tttgtaatca ttccgtcaat ggctttaaat tcatagcccg gataaataaa 2258041 aatagatgtc cagccgcttg atgctttaaa ttgcccgtca tgttctccgg caatcgtctc 2258101 aagcgtgcgt gtcgaggtcg tgccgacaga aatgatccga ccgccatttt ctcttacttt 2258161 gtttaaggct gcagccgttt cttctgacat ttgataaaac tctgcatgca tattatgctc 2258221 ttccacttca tcggcactca cagggcgaaa cgttccaagg cctacgtgca gtgtgatgaa 2258281 ctcaatttgc acgcctttgt ctttcagctg ctgtaagatt tcttccgtga agtgaaggcc 2258341 agctgtaggc gcagcagcag agccaatttc ttttgaatac actgtctggt agcgctcttt 2258401 gtcatcaagc tgttctttga tatatggagg gagcggcatc tctccaaggg attcaagcac 2258461 ctcgtagaaa ataccgtcat attgaaattc catctttctg ccgccgtgct caagctcttc 2258521 cgtgcagatt gccttcaatc ttccgtctcc aaatgtgaca acagttcctt ttttcacccg 2258581 tttcgccggt ttggcaagtg tttcccattt atcaccggtt tcctgtttca acaaaagaag 2258641 ttccactttc gcgccggtat cctcttttgt gccgaataac cgcgcaggca gtacccgggt 2258701 attgttcagg actagacaat cgccttcgtt aaagaagctg ataatgtgtt taaacgagct 2258761 gtcagtaagc tctcctgtat gtttatcgag caccatcagc cttgaagcat cacgctgctc 2258821 caacggtact tgtgcaatta aacgttctgg tagttcaaaa tcaaataaat cgactttcat 2258881 gatgatttca cctttattct agtcttttgt tatttcattc tgccaaaaag attaagcaaa 2258941 attgataata ccacacttat aataatacaa gtgacaaccg ggaagaaaaa cgtaacattt 2259001 ccttttttta caaaaatatc tcccggcatc ttgccgacaa aatgcaaaac tgctccgata 2259061 ataagcaaaa cagcaccaag aatcataatg atcttaggaa attcagtcat atcggggagc 2259121 ctccatttgg aaatgatgat aaacggccgg tgtcacgatc cttccacgcg gcgttctttg 2259181 tataaatcca atttgcagca gatatggttc atatacgtct tcaatcgtat gcgattcctc 2259241 gccgatggta gctgaaatcg tatcaaggcc tactgggccg ccgttgaatt tttcgatcat 2259301 gcccatcagc agcttatgat caatatgatc caaaccgagg cggtcaacct gaagccgctc 2259361 cagcgcattc tgagaaatgt cttccgtaat cctgctgtca cccagcactt gggcgaaatc 2259421 gcgcaccctt ctcagcaggc ggttcgccac gcggggcgtc cctctcgatc ttcttgcaat 2259481 ttcaagagcc gacggtttat caatctcaac ctcgaataca tcagcggttc ttgtgacaat 2259541 atccgccagt tcttcttgtg tatagtactc aaggcgagac attacgccga atctgtctct 2259601 taaaggagcc gtcaaaagcc ccaccctcgt cgtggctccc accagcgtaa aaggcggaag 2259661 gtcgaggcga accgagcggg cagatgggcc tttgccaatc acaatgtcca ggcaaaagtc 2259721 ttccattgca ggataaagca cctcttcgat cgatctgtgc agcctatgta tttcatcaat 2259781 aaataataca tctcccggtt ccagcgccgt taatatagca gccaaatcac caggcctttc 2259841 aatcgcaggc cctgatgtcg tccgcaattc cactcccatt tcattagcaa caatcgaagc 2259901 aagcgttgtt tttccgagtc cgggcggccc gtacagaaga acatgatcca gcgtctcctg 2259961 tctcattttc gccgcatcta taaacacgcg caaattttct tttaccttat gctgcccgat 2260021 atactgtgcc agattttgcg gcctcaggct ttgctctatc actgattcat ggttgtctgc 2260081 ttcacttgag acgagccgtt catccatgaa catcacctta ctttaatagt ttttgtaatg 2260141 cttttttcac atattggtct gttgtcagcc caatttcttc tttaaggtga ggaagcacct 2260201 ttttgatttc tttttcagca tatccgagaa ccctgagggc ttcaagtgct tcttcaagag 2260261 ccgtttccgc tgtttgcttt tcaagccttt cttcatgatt aaacagattt tcaatcattt 2260321 caggcacaac atctgccagc tttcctttta aatctagaat aatctggcgt gcggttttct 2260381 ttcctactcc aggaaacttg accaaaaaag cttcatcttc attttcaatt gcttggatga 2260441 ccgctccggg atcacccgag cccaagatgg caagtgctcc tttcgggcca attccggtca 2260501 cgtttaacag ctttgtaaag agcgccttct cctctcttgt tgaaaaacca taaagcgaaa 2260561 aagcatcctc tctgatatga tggtatgtaa aaatcgtttc ttggcttctc tccttatata 2260621 taaacggatt cggcgtgaaa atctgatagc cgatgccgcc gttctctatg acaatatatt 2260681 ggggagatac ataatcaatc gtccctttaa caaattcaat cacgcaaatt cacctctttg 2260741 actgttcttc attgtaccat aaaaacagcc aaagtcttat agaaaagtta acatatgttc 2260801 gcttctctct cattctttca cgaaaaaaaa gacatgaata catgtcttca atcagcggac 2260861 gctacccgct gtatgtcttc atatgttcga tgacatcctc aaactccgct tttgtccgaa 2260921 atggaatgcc tttcagcaga tttttttgca tatggctttc cagcctttct aaatcaattt 2260981 gaaaaaaaga ctgaattggt tcggaagctg gctcaggccg cccatgaaaa gtggaaatca 2261041 ctccattatc cgatacaccg atatacccgt tgaccttgct gagcggagaa atatcgtcca 2261101 tttgcttccg gaagagcaca tatccctttt tttgttccac tagcgtccat ccggcataag 2261161 ctgcccaaaa atcatccata gaaaacactt tttcatgctt atgctcaatg ctgacatcgc 2261221 cgtccaaata caccttttca agctgcacat gcacctgcag cggctcatag tgctccactt 2261281 ccgcgccaag tgcgcgggaa ggagctccta ttaaaaatac tgccgctgag caaagaatgc 2261341 ccagcaaaag atacgccgtg ctgaatcgtt tcaccctcta cacctctttg cacacgttta 2261401 tgattagttt gaccaaagag gctactgctt aaccgtttta tcaaaatttg tctgcacatt 2261461 ttccctgaca aaccgttcct ccgtatacac atctgtgctt tgctcagaaa ttgtcaagaa 2261521 tcgcgtcaga aaggcactga aaaaatacaa tgccgcaaag atccaaatca cgccacctgc 2261581 accgagcggc ccaatgaaaa gactcacgat gcccggcgcg ataaacgcac ataaaccaga 2261641 tcccaaattc aacactgaca tggcagcacc tttattatca ggtgcaagcg tcggcaaaag 2261701 cgcgcttaat gggacgtacc ctgctaaagc cgcgccgtag cagcaggcga taatcatgag 2261761 cacccaatac tgatgcccga tcagctgagg cgtgtaatac agcgccagcg taaaaatacc 2261821 gcatccgaca ccgccaaacc acatgaccgt attgcgccag cctagtttat ctccgactgc 2261881 accgaaaatg atattaaaca caatattcac aaaaaacagc gtcccccata tttgcagcca 2261941 ttccgaaacc gaatacccgt atcgtgctaa ataagtagga agaaagatgg caaatccaaa 2262001 ttgtcctatc gcattaatcg tcttgaccac tccgccgatg cctaccttag ggttttcaaa 2262061 cataatcgta aatgccttcg acagttcttt ccatttcggc tgatcttgtt tttgtatcgg 2262121 agtaaattta tctttgttaa aaaataaggc aagaattccg cctgccgcca caaacagtaa 2262181 agcgctccaa agcgtattga tttctccaaa ggccggaact gcatagctgg aatagaacgg 2262241 accgagcacg ttaaggccgc acgtaaacat aaaccaaaac cagccgacgg cttttccaag 2262301 aatattttga gaggtgctgt atgacaccca tacgagaaaa gagtatgcaa acagcggata 2262361 tcccaagcct ctaagagcat agctgcccaa gagagccgga taatacatat gaggaatcgc 2262421 ccagccgata aaagcggccg aaccgaggat aaatgcaagc aatccgacag tcatcgtttt 2262481 tctcggcccc caagtttgga caaacgttcc tgaaagccaa gctgagatgg tgacagcaat 2262541 gccgtacatg gtaaataacg atgcggattg ctgcatactg agaccatgat caacgagaaa 2262601 aggagacagc cagccttgtt cgaggccgtc tccaaccata aagatgacaa cgccaatata 2262661 accccaaacc atgtgagaag gaattccgat tttgttcaaa acatttcctt tagcatgtac 2262721 tgtattcatt ttctccaccg cctacttaaa gtatcaatgg agtatatacc caagcttgct 2262781 gaattgtaat cctgttagat taaaaagcga ttttttcagt gtgctcaatg ctaacaggca 2262841 tgccaaaagc aagcgattgc tgtgctgctc tggcgatcct cccggcctgt aaaccgtcat 2262901 tgccggtgca gggagtctcc tggtttgtgc cgatcgcttc tgcaaaacgg agaatctcct 2262961 cctcatatga atccttatag cgttcaagga aaaagaaatg cggtttatcc ttcatcacaa 2263021 aatcagctgt tgacacctca accgttgtcg gcctgctatt gtcagccgct gcagagcctt 2263081 tcgtcccgaa aacctcaacc cgctggtcat atccgtacac agcttggcgg ctgttatcaa 2263141 tcacagccat ggcaccgttt tcaaaagtca gtgtaataac agctgtatca atatcaccca 2263201 gctccgcaaa agaaggattc accaaagccg cccctttggc atacacttcc gtcacttcgc 2263261 ttcccataat atatctggcc atatcaaaat catggatcga catatccata aacaatccgc 2263321 ctgacgtacg gacataatct atattcgggg gttctgggtc ccgggacgtg atttttaata 2263381 aatgaggtgt accgatttca ccattttcaa caatcgtttt gattttctta aaatgaggat 2263441 caaagcggcg gttaaatccg acttgaagtg ttaccccgtg tttccggaca gccgcaagcg 2263501 cttcactcgt ttcgtccaga gagaaactaa cgggcttctc acaaaatata tgctttttcg 2263561 cctcggctgc ttctttgatc atctgtgcat gtacggctgt aggagagcaa ataaaaatag 2263621 catcaatatc aggatcatgt aataaatcac gataatcaga ggttatgtat tcaatctgat 2263681 gactgtcggc ccagcttttt atacggctcg cctgaatgtc agagattgct tttattttca 2263741 tgtgaggaat ccggcttata ttttgaacat gaagtttgcc gatgcggcct gcaccgataa 2263801 tccctgtcac aatctgtttt gtcatggctt cttccccctt gatcattcac gaaagcgctt 2263861 tatttaaaat taatactatc ccatttgtaa gcgcttttca agaatggaaa ttaaacgttc 2263921 tatgtctctt ttatcacaat tcatgcttat aagtagcctt cttcttcaag accagataca 2263981 ctagaattag gctctttttc ctgaacagtt tatgattttc ctataaacag ctgcataaaa 2264041 tagagcaaag aaggtgaatg aaatgctgac aaaagcagag gcactggccc ataccgtcat 2264101 ataccgcaag aacagcagat ttgataaagt caaagagaaa tccgaggaat taacactaat 2264161 cggcaaggga agaagcgcct atgtgtttgc cttaacagaa ggcggtcgaa aaatggcgct 2264221 gaaagtattt tttccggaat atcaagcgac agcagtcaaa gaagcagcga tctatgaaaa 2264281 attagccggg tccgcattct atcctgacat ttacgaaact ggcgattcat ttattctcat 2264341 ggaatatatt aaaggtgaaa ccttttataa ctgtctgaag aaaggcattg caatcagtga 2264401 tgacatgatt cagcaggttg aagaagcgct ttctgacgcc cgggcagccg gactgaaccc 2264461 gtcagatatt catttgcgga atctgatatt gacagaaacc ggggcggtgc gggtgattga 2264521 tgttgcgaga tttgagcaga caaaaacatg cacgcagtgg gacgacttaa aatccgcata 2264581 tcatgcactc tacaaaaaac cgatattccc caaaaagatt ccgggttttt ggctggagat 2264641 catcgcattt ttatataaga aagattggtt tcaaaagcat ttcgcacagc ggaaaagaaa 2264701 atattcttaa atcaaaaagg cagccgcaca agcggctgcc tttatcatgt attttttact 2264761 ttctgacggc agaaatcagt ttcatttgtt caggcgacag cttaattcga tagcctctca 2264821 cagttaagta gaccgcttct gggtccttct cgccggaatg acaatacgtt ttttccattt 2264881 ctgtctcccc tcacccttta ttggctttat ttcatcttat cattgcttta ttgaggtaat 2264941 tttaaagaaa tgtaaagatt atatgaatcc gatatatagt aaaatgagag aaaaaaaggg 2265001 agagagtcac attaagaccg aaaacacctt gagcttagat gcagccagag gtgaacttgt 2265061 aaatgaaaaa acacttgtca agagaacaat ctactggaat tacccggaca gccgcccagc 2265121 agtgacgtgg atcaatcaca atacagtgaa aatcggcaat cagactttac atcttgatac 2265181 tgatgaaacg tatgattggc gaaaagatga tcattggatc cgtgaagaac cgccgcaggc 2265241 gtcagtgagg tgatgaaaca tgaataagat gaacggaaca aatgatgaaa agcatttcaa 2265301 tcattttgtg attgctttat cctttatata cggtttgact gaactaggct atttgttgct 2265361 gaaggatttt ataacaattg ccataagttt gcctctgtag aaaaacgcag cgtagtcgat 2265421 acgccgcgtt ttttcttttt cccttcctct tcttattgat aattacaggt catataatgt 2265481 gacaaatcga ttgtagaaat agttcgatta gaccaaaatc ctttttatac atgtattcga 2265541 atttgaagtg agggggaagc ttgatggcag attttgttgc tagtttgaat gcggtcttat 2265601 ggagtacgcc cgtcatttat attttattgg gaattggatt cgccttttca attatgaccc 2265661 gttttttaca agtccgacat ttaaaagaaa tgattgttca gatgttcaaa ggcaagagct 2265721 ctgaagccgg cgtttcatct ttccaagcgt tatcgattgc gctgtccggc cgtgtgggca 2265781 caggaaacat cgcgggagtg gcgacagcaa ttgcattcgg cggacccggt gcagtgttct 2265841 ggatgtgggc gattgccttt atcggggcgg cgagtgcctt tgtagaatca acgcttgctc 2265901 aaatttacaa agtgaaacaa gacggtcaat atcggggcgg ccctgcttat tatatagaaa 2265961 aaggcttagg cattaagtgg tttgccgtct tatttgccgc tgctgccctt attgcaatgg 2266021 cctttctaat gccgggcgta cagtccaact ccattgcggc tgggatccaa aatgcattcg 2266081 gcatctctcc tttcgtcaca gggtgcggtc tggttttatt attagggttc attatttttg 2266141 gcggcgtcaa acgaattgcc aatgcggcgc aaatgattgt tccatttatg gccattggat 2266201 atatcctgct gtctttgatt attattgtca tgaatgtgtc tgaattgcct gctgtgatct 2266261 cattaatatt caaaagcgcc ttcgcattgg attccgcttt tggcggcttg atcggtatgg 2266321 cgatttcctg gggcgttaaa cgtggcattt actcaaacga agccggccag ggaacaggcc 2266381 cgcatccggc agctgctgca gaggtttctc atccggtcaa gcagggactg gttcaggcat 2266441 tttctgttta tattgacacc ttgtttgtat gttccgctac agctttcatg atcttgttta 2266501 ccggcatgta caatacccag gctgcagatg gttcctttat cgttcaccag cttaaaggcg 2266561 tagaagcagg acctggtttc acacaagcgg caattgacag tgttcttccc ggattcggtg 2266621 caggctttgt tgccatcgct ttattcttct tcgcttttac aacaattatg gcgtattact 2266681 acatcgcaga aacaaatatc gcctatttag cacgaggcag agaaagcaaa tgggcgatgc 2266741 ttggcttaaa actgattatt ttagccgcca cgttctatgg tactgtgaaa acagcttcac 2266801 ttgcttgggc attaggggat gcagggcttg gcattatggt atggctgaac gtcattgcca 2266861 ttgtgctgct tgccaagccg gcgctccttg ctttaaagga ttatgagcgc caaaagaagc 2266921 agggcttaga cccgatcttt gatccaaaag cgctgggtat caaaaacgct gatttctggg 2266981 agaaagaata cactcatgaa agtgaacgtg tctcctgaac atactaaaac cggcccgata 2267041 tgacctcgtg ccggtttttt atgaacgata gtttgtatac acttcttgaa catcatcgtc 2267101 atcttcaagg acgtctatta atgtttccag cttctcaaca gcctgatcat cggcttctgc 2267161 ataggtattg ggaagcatgg tcacctccgc cgaagaaatt agatatttcg attcgagggc 2267221 tgttttcacc tcttcaaaat gctcaggctc tgtgaaaacc tcatataggt cttcttcaat 2267281 tcgcagctct tctcctcctg cttcaagcac atcaagcatg agctcatctt cttctatttg 2267341 ccgttcagta cggtctatcg taatgaaccc ctttcgttca aataaaaagg ctacacatcc 2267401 gctttctccc agacttccgc catttttatt aaaggctgtc cgcacatttg acgccgttcg 2267461 gtttttatta tctgttacgc attcaaccat gacggcaatc cctgaagggc cgtagccttc 2267521 ataggtgatt tcttcatagc tgcttccgtc ttggcctccc gcagcttttt taatggcccg 2267581 atctatattt tcattcggca tattggcgcc ttttgctttt tcgatgacaa gacgcaatgc 2267641 tgaatttgct tctggatccg ctccgccttc tttcgctgcc acatagattt cttttgccag 2267701 cttcataaat attttcccgc gctttgcatc ctgtgcattt tttctttttt gaatgttttt 2267761 ccacttggaa tggcctgcca tgttttcacc ttcttttaca ttttctatgt acactttaat 2267821 gggaaatgtt cgctgatgca aagaaaaagg ctgccgaata tcacttccgg cagcccttcc 2267881 ttcctagcgg ttgttcattt tatgaagttt tctgaacagc cctttatctg ttgatacttg 2267941 gacgtcacgg ccatttgcat agttgcgcgc tgcttttaca acattatctc tgtcagactt 2268001 tgtgaactct ctgtggcttt tgactgcgat aactactcgg tcatccgata ccataacttg 2268061 tgtgtcattg acgtttttca cttgtttcac acggttggca atttttgcag ccagtcttct 2268121 gttttcttgg ttgtcatacc cgttgttcgc tgcattccga ttcatgtttc ggttattcgt 2268181 gttgttatat gttccgtcag ttgccaaagg aacacgatcg tcagcagtaa cacggtcacg 2268241 gttatttaca ttcgtggtgt ttcggttacc gtcgttctga tcctccatta attcagaaac 2268301 aggaccatcg tggtcgattc cgtctccctg tctatcggcg tcattttcat ttgtataata 2268361 tccgattgga cgggtattgc cgttattgcg cgtatcattc atagcattat cgtttgctcc 2268421 gcatgctgtt aagccggctg tcattagaat caggctagcg atcgtcattt ttttacccaa 2268481 tggaaaaacc ccccgtggac gaattgagca tgtttgctcg cttttatcat gtgcgtatgg 2268541 ggggcatgtt aagcgtgtca gttctctcca tttggcagtg atctgcttga aaacaaaaaa 2268601 aggaacgatt tacatcgttc cgaacgatca ctcattttct tcttccggac ggccaaacat 2268661 ttggtttaca gaaggctggt tcgtcattgg catagaaact cctgccgaat atgggtttgg 2268721 atttgggtta gctgtgccat atggcatatt agggcttcca taagctccca ttcccgaatg 2268781 gccaggtgca gagaaatatg gctgatgatc accgtcacag ccgcagtcgt catgatcttt 2268841 gtatggcatg taaccatgag ccgcagcagg ctggtatgct cccattactt ggggagtgcc 2268901 gtaataaggg ccatacggca tatgtccata cggagatcca taagccggag atgcgtattg 2268961 cggcgcaccg tatgaaccgt aatgtccgtg atggctgttt tcatgatgct ggttttcata 2269021 acccgggtca tactgaggcg atacaaagcc tggctggtat ccatgcatcg gatgcattgg 2269081 ataagcttgt gccggatagt acggatagca taatcctgat cctggaagaa ttggcgaaac 2269141 aggcaccgga cacggtacga aatgagccgg ataatgataa taaggctgaa cagccggcat 2269201 cggcatattc ggaactgtgt gatgaacgtt ttcctcttct ataccgccta cctctggcgc 2269261 ctttggcata ttaggcatat tcggataatt tgcattttcc atattactca tagcctcctg 2269321 ttgtggaaat tggtcttgca tatgatacat atgatccata tttccgtcat gatgtttttt 2269381 cggctcctcc ggtttaggag gcgaccaagg ctggaaaagc tgtttcatat cataataatc 2269441 gttcacatca gcttcagggt acacattttc ctgcaaatta ggcatcggcg ggacatacgg 2269501 catggacttc ttttctttcg gctttgtgtc ttctacatcg acaacggatt taggcttctc 2269561 tttcgcatat ggatgttctt gcttcacact cccggccgca ggacttttgc ccgcttttgg 2269621 ctcttttctg accgggactc cttctgacgg cacttttatt ttcattccag gcatgattaa 2269681 gtctggattg ctaagctgtg tattgagttt tttcacttcc tcaacatcga ctccgtactt 2269741 ttcagctatt ttccagagcg aatcgccttt ttgaacgata tggattttca acgttttccc 2269801 ctcctatgca aaacgtgaac agttcagctg tgattacaat atgtttcttc acaacatatg 2269861 cctgaacaaa agaagttatg agtaaaggaa gggaaaatat ttctgatcta cgtgatcgaa 2269921 agcattcgat tcagggcaag gagtgcatct tcctgaatgg cttttggcac cttgatgacg 2269981 cctgaaggtt ctcctttttc aatttgttcc agcgaccaca acaaatgcgg caaatcaatt 2270041 cggttcattg tcaggcaagg gcacatgtca gggttgagtg attcgatttg tttatctgga 2270101 tgctcgtgaa tgatccgctg aacaagattc atttctgtcc cgattgccca cttgcttccc 2270161 gccggagcct ggttgattgt gtcgataata tatttcgttg atccgttatc atcgcttagt 2270221 gtcacgactt cgtgtgaaca ttccgggtgc acaatgatct gaatgtcggg gtctcgctct 2270281 ctcatatcat ggatattttt agtggtgaat ttctcgtgaa cagagcaatg ccctttccac 2270341 aaaatcactt tcacattcgt atgcccggat tcagctacta attcatcttt catcggatcc 2270401 cacacagcca tatcttcaag cgcaatgccc agatcataag ccgtatttct ccctaaatgc 2270461 tgatcaggca aaaataaaat tctttttttc tgtgtaaacg cccattcaag cacttttttc 2270521 gcattcgaag aagttacagt tgctccgcca tgctttccga cgaatgcctt gatctccgca 2270581 gtggagttca cataagttaa aggtatgatc gtatctccaa atatatgctg aagcttcttc 2270641 catgccctat tggtctgctg catgtcagcc atgtcagcca tagaacatcc agctctcata 2270701 tctggcagga cgaccgtttg ctgctcgctt gtcagcatat cggcggtttc tgccataaag 2270761 tgaacgccgc aaaatacgat ataatccgct tctttgtttt tttccgctac ttgggccaat 2270821 tgcagggagt cgcctgtttg gtcagcaaat tgtatcactt catccttttg ataatgatgg 2270881 cctggtataa agagcctgct gccgaacttt ttcttaatgg cggcaacgcg cgtttccata 2270941 tcctttctcg atagttcttt ataactttcg ggcatcatat cattcgattg tttgatcaca 2271001 tcaagaattg acataacagc attcctccac agattcattt gataacgtaa catccatgct 2271061 gatatctaaa cttttgacgg aatgagtcag aaatcctaat gaaatataat tcacacccgt 2271121 ccctttaaaa gcaggcaaag attctaacgt aatcccgcca gaggcttcag tttttatatt 2271181 agccggtgtg agctttgcaa aatgacggac cgtatcaggc ggacagttgt caaacataat 2271241 aacatccgct ccagctgcaa ttgcttcccg cagctgttcc tccgtttcaa tttccacctc 2271301 gatatttacc atgtgccctg cggcctgacg ggcttttttg cacgcctcta aaatagagcc 2271361 gcatgctgcg atatgattat ctttaatcat gatgccgtca tacaaaccga atcgatgatt 2271421 atacccgccg ccggctctga cagcatattt ctccagcatt ctgagccccg gtgttgtttt 2271481 tctcgtgtca caaattttaa tctgttcatc atccagacac cgaacagcct ctcttgtcat 2271541 tgtcgcaatt cctgacagcc tctgaataag atttaatacg acccgctctc ctgaaaggag 2271601 cgcagctgcg ggaccgtgta actcggcaat cacttcacct ttatgcaaca tgtccccatc 2271661 ttttttgtgt aaaatgcttt gaacattttc gtccaataac gaaaagcctt cttttatgat 2271721 cgctgctcct gcaaaaatac cctctgactt tgcaacaatc tccgcttcac agctctgttc 2271781 tccaaaaata gactgcgatg taagatcccc tgtcccaata tcctcaagaa aaaagtgatt 2271841 cagtaatttt ttcagctgta aatgattcat tgttccaaat cccctcgttt tttctgatct 2271901 tcgttccttt ttttgtatgg acaatttgtc ttccttgcca gctcacctca gcatgaggaa 2271961 aatcggtgcg gaagtgagcc cctctgcttt cctcccgcaa aagcgcagaa aacgtcatca 2272021 gctttgcagt ttgccataga tgagaaagtt ccatctgccg aattgtgata tccttcacat 2272081 ttacttcctg aaaaggcagc gtatgaagcc agatgctaag ctcaatcaaa ctgctttgtt 2272141 cccgcagaat agacatgtgg cttgtcattt tgctttgcag ttcatgcccc tctatatccg 2272201 gcacctcgta gaagacactg gtttctagcc ctgattgata ttgcctgtta taaaccggtt 2272261 tttggataat atgctctgct gccctttttc caaataccag cgcttccaat aaagaattgc 2272321 ttgcaagccg gtttgctcca tgtaaaccgg agcatgctgt ctcgccaatc gcataaagcc 2272381 ccggcactgt cgtttctccc cagcgattaa ctgaaacacc tcccattaag aaatgcattc 2272441 ccggagcaac aggaattttt ccgctgtgga tatcaatccc tgctttttca caaatagcgg 2272501 tgatggtagg gaaacgcgtt tcaaaatcag aaatcgcact gaagtctata taaacgcgat 2272561 ttccttttgc catttcttcg tgaataaccc gtgagacaat atctcttgga gccaggtcac 2272621 ctaaaggatg ccgttcagcc ataatcctgc ggccgttttc gtctactaaa catccgcctt 2272681 cccctctgac agcttctgaa acaagcccgt aggaaacacc atttttcaca agcagtgtcg 2272741 ggtgaaactg agtaaactcc aaatccgtta attccgcccc ggcccggtaa gccagagaaa 2272801 gaccgtcacc tgtgacagtg agatcattcg tatggtgaag aaacaggttt ccacagccgc 2272861 cggcagccag cacaacttcg tctgcgtgcc ttaccttgag ccgccctttg ctgtcttttg 2272921 tcatgacgcc gatacatcgt ccgtcctcta taagcaaatc tgctgccgtt tcattctcga 2272981 ttaacttgat tttgctgttg atccgtttga gcaaataatc gataagcagc ctgcctgttg 2273041 cgtctccgcc tgcatgaaat atgcggttgt atgagtgggc cccttctctt ccaagacaaa 2273101 caccgcctcg ttcattgcgg tcgaatggaa atccacgctc caataggctt tgaaccatca 2273161 tttttccatc atgtaatacg tctgctacaa tagctagatt attatggccg caccctgcgt 2273221 ataacgtatc ctccagatgg gcttcaatcg agtcatcttt tgcataggcc gcagcaatcc 2273281 cgccttgtgc atagacagaa ttgctgtttt tgacgctttt ttttgtgata acagtcactt 2273341 cgtatgaggg cgggaaagct gcagctaagg aaagtgccgc cgcccctgaa ccgatgactg 2273401 caatcgtctt tttagacata tgccatcctc ctgttgttta cacctgtctt gacacctata 2273461 tttacacaag gataaaataa actcaagagt tttttatgga gaacggatgg aggaagaccg 2273521 gatgatttat ttagattatg cagcgacaac gcctatttgt gaggaagccc ttactgtata 2273581 tcagaagctt agtatggata tgtacggaaa tgccagcagc ctgcatgatg caggaggaaa 2273641 agcaaagcac atactggagt actgccgtga aaaaatcgcc aacatcattg gcggagaagc 2273701 aagcggcatc tattttacaa gcggcggcac tgaatccaat tttctggcca ttcaatcatt 2273761 gttaaacggc ctgccaaaaa cgaaaagaca ttttattacg actgccatgg agcatcagtc 2273821 cattcataat tgcgctgctt ttttggaaca gcagggatat gatgtaacag tcattgaacc 2273881 gaatgaatac gggcttatta ccgaggaaat attactaacc catatccggc cggaaacagg 2273941 ccttgtatct attcagcatg caaattctga aaccgggatc attcagccca ttcaacacct 2274001 gtcttcatac ctgcacaata aggggattct tcttcattgc gacgctgttc aaacgtttgg 2274061 aaagatcccg atcaatacaa aaaatctggg agtagatgca ctctcaatgt ccagccataa 2274121 aatccacggt cctaaaggag taggggcggt ctatatccgg ccggatgtcc cttggaaacc 2274181 cgtttatcct ctgactactc acgaatacgg attcagagcc ggcaccgtaa atgttcccgg 2274241 gatcggtgcc ttcactgccg ctgcagaatt gatcgtaagc gaaatggaaa aacagatatc 2274301 ccgcaatgag gcattaagaa catactttct agaccaaatc cgtattcggt ctctccctgt 2274361 aacccttgca gcagacactt cgaaagcaga atgtcttccg catattatag ggtgtttttt 2274421 tcactcattt gaaggacaat atgttatgtt agaatgtaat cggagtaata tttgcatttc 2274481 aaccggcagc gcttgttctg caggttacca cggtccgtct gaaacaatga aagcattaag 2274541 aaaaaccgaa caagaagctc tgcaatttat ccgcatctct tttggcaggc atacaacagc 2274601 tgaacagctg gaacagttat tacatacgtt tacagtgctt tgggaacaaa agaaaggaga 2274661 atttgatatt gaccgaagaa ttaaagctaa tgggcgccaa caggcgtgac cagcttcttc 2274721 tgtggctgaa ggaatctaaa tcaccgctga caggaggaga actcgcaaaa aaagcgaacg 2274781 tctcaagaca ggttattgta caggatatat cgctcttgaa agcgaaaaat gtaccgatta 2274841 tcgccacaag ccaaggatat gtatacatgg atgcagccgc tcagcagcac cagcaggcag 2274901 aaagaatcat agcatgtctg cacggtcctg aacggacaga agaggaactg cagctcatcg 2274961 tcgacgaagg cgttacagta aaagacgtaa aaatcgagca tcccgtatac ggagatttaa 2275021 ctgcagccat ccaagtaggc acccggaaag aagttagcca tttcatcaaa aaaatcaatt 2275081 ctacgaatgc tgcctactta tcacagctga ccgacggcgt gcacctgcat acactgacag 2275141 cacctgatga acatcgcatc gatcaagcct gccaagccct cgaagaagcc ggcattttaa 2275201 ttaaagacta aaaaaagccc tctagtgggc tttttttata attggtaaga ctggtatgca 2275261 cccagaagcc tcactttgca gccgagtgct tcaagctcct gcatggcccc tggaatcaat 2275321 acatcatcaa acgctttctc aatatcaata ataaagaaat aatggcctaa tccggtttta 2275381 gtcggacgtg actcaatttt tgacaggttt aaatttctcc aagaaaatgc agacagcact 2275441 ctatgcagcg ccccggactg atcatcctgc ggcagcatga ccattaaggt cgttttgggc 2275501 ctagagctca attttgaatt cacttcaaaa gatatgtttt catcgggaga caggataaca 2275561 aatcttgtat gattgtccct ataatcctgt atatcccgtt tcacgatttt taattcgtat 2275621 gtagaagctg ccatatcatt ggcaatgacc ccgatattca gctcgggatg gtcactgaca 2275681 aactttgctg ccgccccggt agaattggcg tattcatatg gaacggaagg aaaatgtcga 2275741 tgaagaaatt tatggcattg cgcaatcgcg tgtgaatgtg agtaaatttt gtcgagctct 2275801 ttccatgcat tctctcttga gggatggacg agcaagtgct ggtgaatcgg caacgtcatt 2275861 tcacccacga ttggcaaagg ctgttcatgt attaaatagt ctattgttag attaacagat 2275921 ccttctaaag cattttccaa aggaacaaaa gcaaaatcaa cttcgcctgc aacggctgca 2275981 tctatacact ccggaatggt gcggtaagca acatgttcgg cgccgttttg aaaacaagaa 2276041 ctgactgcta gatgtgtaaa tgtagctgct ggacctaaat aaccgacttt catgacgatt 2276101 ttctctccct tatgcacctg aacctaatat ttcaaccttt tctacaaaat caaacttcct 2276161 gagcttattc attaatgtat gaatgtcttc ttccattgcc gacgtactga tagacagtgt 2276221 cacatttgct ctgccttgaa gcggaatggt ctggtgaatg gaaagaacgt tgcttccaga 2276281 atcagctacc gcctgaagaa gctgagataa cgcacctgac ctatcctcca aatgaaagaa 2276341 aagtgtgata atttgttctt ttaccatggt gtagaatgga aaaacagcat ccctgtattt 2276401 ataaaacgca cttctactta aatcgacctt ttgaacggca tctgctactg aatctgcttt 2276461 ttttcgatca agcagctttt tgacttctaa tgtttttctc attgcatcgg gcaatacatc 2276521 ttcacggaca agataaaatg tctcctcttt catttgcatc ccccctttaa aatagagagc 2276581 ctggcaccag gctctctttt cagccaacat tgattaatca ataaattcaa attcaaattc 2276641 cagaagcctg attatatctc catccttggc tccgcgttct ctgagtgctt catcaacacc 2276701 cattccgcgc atctgtcttg caaaccgttt aaccgattca tcacgtgaga aatcagtcat 2276761 cttgaataac cgctcaaggc tgtctcctga aagcacaaat acaccgtctg gatcgcgtgt 2276821 aatgttaaat ggcacttctt cattttccat cgtgtacatg acacggtttt gtgtaagctc 2276881 ttcctcgtca tacagcggga attccggtgt gttctcaagc tgattggcaa cctcaaacag 2276941 aagctcacgc agaccttctc ttgtcaccgc actgatcggg aataccggat aatcatccgt 2277001 cagcttttct ttaaaggctt cgagattttc cgcagcctcc ggcatgtcca ttttatttgc 2277061 aacgataatt tgcggacgct cagtgagacg cagattgtac tcgctcagct cctggttaat 2277121 cgtaagataa tcatcatatg gatcacggcc ttctaagcct gacatgtcaa tgacatgaac 2277181 aataaccctc gtccgttcaa tatggcgcaa aaactggtgg cccagtccga cgccttggtg 2277241 tgcgccttca atcagccctg gcaaatcagc catgacaaag ctgcgtccgt catccgtttc 2277301 aaccatgccg agattcggga caagcgttgt aaagtgatag tccgcaattt tcggttttgc 2277361 agatgagaca acagacagca aagtagattt tcccacactc gggaacccga caagtccgac 2277421 atctgcaagc acttttaatt caagaacaat gtagcgttct tttcccggct cgccgttttc 2277481 tgaaagctga ggcgcgggat tagccggtgt agcaaagcgg ctatttcctc ttccgcctct 2277541 tccgcctctt gcaatgacag cccgctgtcc gtgctctgtt aaatcagcga tgacctgttt 2277601 tgtatcatcg tctgtcacaa cggtgcccgg cggaacttta atgaccatat catcagcatt 2277661 tcgcccgtgc tggtttttgg acatgccatg ctcgccgcga atcgctttaa agtgtttttt 2277721 gtatctaaaa tccatcaggg tgcggagacc ttcatctact tcaaaaacga cgtctcctcc 2277781 ctttcctccg tcaccgccgg cagggccgcc tttcggcaca tatttttcac ggcgaaacgc 2277841 aaccataccg ttgccgccgt cgccgccttt tacatatact ttgacctgat ctacaaacat 2277901 aatgtcctcc gttctaaacc gttaaaaact ccgctagtcc aacccaattt caatcagaca 2277961 ttcgtgactc gtgatttcaa aacgcatgat atcaacgtcc tcatatccat tctgccgaat 2278021 atcatcaaaa gcagatggat cggcaaaggc gccgtgaaaa tcaaggtaca gaatcagctg 2278081 tctgtcagga tgatccgttt gaagcgaaac cgttaaatga ttttcactct ctctgctgac 2278141 tgcttgatca aacagatgaa acagctttct catcagtttc gccagctttt gatcataagc 2278201 cgacaaatcc ttaatttctc cgagaacttc atattcaagc gtcatataat gggttttcca 2278261 attaaacgta agaaaatcaa acgccaaatg cggtgttttc aggtttgaga gctttgattc 2278321 gtgctttgcg tctataacca tttcttcaat catttcaaag acacggtcat acttctgtaa 2278381 gcttaagttt cctttaatca gctgcagctt attcatccaa tcatgccggg aatggccaag 2278441 cagatgaatc agttcgtttg ttaatgccgt gtcgcttata ttttcttctt gattttttga 2278501 aacatccttc attttcgcac tcccaatcat ttaatttctt atttaggagt ctgtataagt 2278561 gtgtattatg aattataaca gagaaggctt tgttagaaaa acaattgttt ttcccagaaa 2278621 tatcatgttc cttttttctg gctttggttg atttgcagcc aggcagaaca ttttatgtat 2278681 tactgcttgg ggaacatatc cagtgggttt gagatgttta ttctcattct tggcggggtc 2278741 tgctcgcaca tactctgcat ttcattctag gtgtttactc cgcatattgc aaaaaaaact 2278801 ccagtcatca tcgaccggag ttttttgaat cattattgag ctacaggata tacgctcact 2278861 tttttgcggt cacggccgaa acgttcgaat ttaacagttc cgtcgatttt cgcaaataga 2278921 gtgtcatctc cgccgcggcc cacgttttca cctgggtaaa tttttgttcc gcgttgacgg 2278981 taaaggatag aaccgcctgt tacgaattga ccgtcagcac gtttagcacc taaacgttta 2279041 gcctcagagt cacgtccgtt ctttgtagaa cctactcctt ttttagaagc gaaaaactga 2279101 agatctaatc taagcatgta gctcacctcc tatattatgt ttgtggtcac acgcaagttg 2279161 tctttgtaat cccgttcgat tgtctccagc gaaacaatca tgccttcaat cagcagctga 2279221 gctttttggc gtgcctctgg atcaagagat tcagggaatt caaaataaaa ataacccccg 2279281 tcctctccta tatcaagaag cggctcgaag cccgcgagca caatgaccgc gttaacggcc 2279341 ccaaacacaa cggctgtcac tccggcacaa acaagatctt gtccatgttc agcaaaattc 2279401 gcatggcccg tcatttcaaa agacaatatg cctttatcat gagaccttct gattgttgcc 2279461 tgaatcatgc ttacgcgttg attttttcga tcgtcacttt agtgtaaggc tgacgatgac 2279521 cttgtttttt atgaacgttt ttctttggtt tgtatctgaa aacagtgatt tttttcgcgc 2279581 ggccttgttt ttcaacttta gccgttactg ttgcgccttc aactgtaggg ttgccgactt 2279641 tcacgttgtc tccgccaaca aacaaaacgt cttcaaaagt aactgtttca cctgcttcag 2279701 cagcaagttt ttcgatgtaa acagtttggc cttcttcaac tttgatttgt ttaccgcctg 2279761 ttttaatgat tgcgtacatt ctctgcacct cctattagac taagactcgc cagataccag 2279821 ggggctgtaa aagctcttaa cacctgtact gagcggttgt agcaatggtg ctacatccat 2279881 aacattaaaa aatataccaa aatacaaggc gtttgtcaat cagttttagt agggcagaag 2279941 cagttcctcc atggaagaat tcgtccgctt atcggcaaag taagcgtgca gcacttcatt 2280001 ctcgtcaagc tggctgagct tttggcctga tttttctata ataatcggat gcttacagcc 2280061 acgtttgaac tcggccatca catgatagac tttatcctcc gcctttactg tcagcggcag 2280121 aagtttctca agctccctgt tttttccgta atacctttcg aggagaaatc tcacatggat 2280181 atagtgcctt tgccgatatt cctcaaacaa ggaaacagcc agaaagacaa acaaaaccca 2280241 tgcgctgatt tgcagaggaa tcacgaataa aacccagcac ccgagcagca ggcagaagca 2280301 gagcgacgtt tttagattaa gccggtgagc cttttgaaaa ggcagctgtt tggaaaacaa 2280361 caaaaataac agttttcctc catccagcgg ccagatcggc agtaaattga caaataagat 2280421 agaaagatta taaaaggtga agagttcaaa ggtatgctga tgaatcactg agacttctgc 2280481 aagcatccag gcggcaaact gaagccagat gtgctgaaga ggtccggcaa taatgaccgc 2280541 aaactcttcc tttaacggcc gattcccgtg ctcttccact tcgaccgttc cgccaaacgg 2280601 cagcaaaaaa acacgcttga ttctccaaga aaaaaacaca gccagagcag catgccccag 2280661 ctcatgaatc aatacaatca ggagcagaca taataatgct ttcatatggc ctgtgagcaa 2280721 gcccagcgcc gcaataatcc aaagaaaagg atgcacatgg atctttaaga taaggtcgag 2280781 ccatttattc aaatgaaatc acctgaatcg gatcaataaa tttatcgccg tctttcatgg 2280841 caaaataata gaccccttta ttatgatcat caagcttaat cgaaccgagc tttttgcctt 2280901 tatccacaaa atcatataaa gcaacatcca catctttgag ctcgccatag atactatagg 2280961 tgttgtcagc atgctgcacc ttaaccgtca gtcccgtttg gctgtctttg ctgacttcaa 2281021 ccacatagcc ttcttttacg ctatcaatct tatcactgct tgtttcgact ttaattcctt 2281081 ccccattgtc ctgaaaatcc tgctgtactt tcccggatgc aggcgcgatc agatctttgc 2281141 ctacttcaat ctgctgttcc ttatttttgt gttcaggagc caggaaagca agcggatttc 2281201 cgaatttggt ttcgaaccaa tggcttgctg aagcaaattg aaattcagtt tcaaaggttt 2281261 tggctacggc gggtttaatc tgactgacgg gtccaatgtt tgttttatag gctatagctg 2281321 aaacgagaac aaggcaggcc gacagaagac atttcaggat aattgaatct gttttcacca 2281381 atgggtgttt tccgttgaat gttggcatgt tatcttcgta gaccggaagt gttccatgct 2281441 tttcctgatc cgttaccatc acccaggacg ggggtttctg cttttcagaa actgtctgag 2281501 tagagaaacg ttttgagccg gaaagctgct ttcttctttt ctctaatcgt tttctgattt 2281561 catctgctct gtgactcatt gccatcatcc tttgcattcg ttgggtttgt acatcatatg 2281621 tcttgtccat ggcaaatatt cggtttagtc aagaacaaag caggcaaaaa caaaaaaaac 2281681 ctgacacagc atatgctttg tcagattctt ctctttgatt ctatcacatt aagatcttac 2281741 tccgaaaaat gacttaatct tagccatcat tcctttgttt tgctcttcaa gcacctgtaa 2281801 aggaacagat tcacctaaga tgcggcgggc aatattgcga tatgcaatgg aagcgcggtt 2281861 tttagggtcc atcgcaatcg gttcgccatg attggaagct ttaatgactt catcatcatc 2281921 agccacgatt ccgagcaaat cgatcgacag atgctgtacg atttcgtcga tatccatcgt 2281981 gtcaccgttt ttcatcaggt gatttctgat tctgttaaca acgagccgcg gcggttcaat 2282041 attttcctct tgctccagca gtcctataat acggtcagca tcacgaacag ctgagatttc 2282101 aggcgtagtg accacaatcg ctttatcagc tccggaaacg gcatttttgt acccttgctc 2282161 gattccggca ggacagtcta tgatgacata gtcaaattcc tgtttgagct cttggaccat 2282221 gtttttaatt tgttcaggag caacagctgt cttatcgctc gtttgagcag cgggcattaa 2282281 atagagcaga tcatcgaaac gtttgtcttt tacgagcgcc tgatgcattt tgcatctgcc 2282341 ctctacaacg tctaccagat cgtaaataat tctattttca agacccatta caacatcaag 2282401 gttgcgcagt cctatatcag tatctactaa gcatacgcgc ttccctaaaa tggctaaggc 2282461 ggtaccgagg ttcgcagatg ttgttgtctt acctactccg ccttttcccg aagttattac 2282521 gatagcctca cccaattcac attcctccct caagccttgt tagatcaggt cttaaatgag 2282581 ccaaatgttg aaggcgttca atgaccatat ttccgtctgt atctaaataa gcacattcca 2282641 tttcgttccc tttttgaatg tggtctgggg agcgatttaa cacatgattg attcttaatt 2282701 gtgtcggaag catttcagag gcggcgatga ccgcttgatt atttccattg aatccagcat 2282761 gcgcaattcc tttcagtgag cccagaacaa aaatgttccc tccggccctg actgttccgc 2282821 cgggattcac gtcaccgatc aggagcaagt cgccttttac ctgcagcact tggcctgaac 2282881 ggacaatttt tgaaacagaa ataatttcgg cttcctctct tatctgctgt gcttcttttt 2282941 tagtaatgac ttcactgtca atagaatgaa caaacaaatc tttctttgac gcaatcaatt 2283001 cggttagctg ttcctcttgc tccttatata aaaagcgatt tcccagctta acatgaacgc 2283061 tgattttctg gccttttcca tcggtatatt gttcaattga cagcatattc tgaagaccat 2283121 cgagaagctc atcaaaagaa cacgcatcat ccagatgcaa tgttagtcca ttctttgttc 2283181 cttttattgt tacatattgc tgctttttgg tcttcacaat attcacctca acaacatact 2283241 catttcgtca aaaaaagata aaatcctttt tactcatctc tcaattcttt ctttagactc 2283301 ataaaaaaca atctaaatgg cagaacaaga ataagagctg ctgcaatatt taataaaatt 2283361 gtcggtataa accggtcaag cacaaatccg ttaaacgtca taatgtcttt atgaatcaaa 2283421 gactgaatgc cgaatacgta aaattcgagc agacagacag ccagaactgc tatcaatatc 2283481 actacaaatg cgtttgtatg caacacttta aacgcttttg aagccaaata gcatagccct 2283541 gcaaaaccaa acatgtaaac gcctaataga cttgtatagt tcatgtcata tagaaagcca 2283601 aaaataaatc cgtaaatcat cgcgtgtttt tggttgataa aagccgacat gaatatcaat 2283661 acaagcatca aaaaacgcgg ggcgagcact tggtcatctg taacgaaagg aaaatgcacc 2283721 aaatctgtaa aaatgctttc cgcagaaaaa acaagcatca taacgaaagg gagaaggaaa 2283781 cgtttcacga tccttcctcc tctgtatcga cagtcggcac gtcacggtta acaacgatca 2283841 cattatttaa atctgtaagg tcagccgcag gttttacata agcaaccttc gttaatccat 2283901 aggaatctga ctcgatatca gtcacttcac cgattgtcag cccttctggg aaaacaccgc 2283961 ctgtccctga tgtttcaata agatcgcctt ttttcacgtc ttgtttatcc ttacgctcaa 2284021 taattgtcat cttaagacgt tttttctctt tgtcatatcc ttcgatcaag ccgtagcctt 2284081 tgctgccttt ttttccggaa atttttgtcg cgactctgtt attgcggtca gtatcgctta 2284141 aaagctgaac agcagacgta aaattgttaa gtccggagct tttgatcttg ccgattaatg 2284201 cgcctttttc gtttgtaacg gccatatctt tcgctacgtt ttgctgagtc cccttgttaa 2284261 tggtgacctg tttcgcccaa ttatcagggc ttctggcgat gaccgttgct aaaatcggct 2284321 tgtaatcttt aatcgatttg acatggccaa gctcgtcacg caaggatttg ttttcttctt 2284381 caagctcttg aagcttggct tcatattgtg tctgtccgtc aagtttttct cttagacgct 2284441 cgttttcttt gtatgtgttt tttaaatcat tgatgttctc aaatattcct gcaaaaaatt 2284501 cggcaggcgt atgaaaaata ttttgaaata ctcccgtcgt atcgccgatc actttctcag 2284561 gccaggtggt attgcggccg cccttcagcg aaaatccaat catagccacc aatatgataa 2284621 tacacagaag taatagcatt aaccgcttat tcggcatcgt gttacacctc ttctattgaa 2284681 ctcccgatta tctagttttc cctttgaaaa gatggatgtg ctccagtgct ttccctgttc 2284741 cgatcgctac acaatcaagc ggatcttcgg cgataaggac cggcattttt gtttcttcgc 2284801 tgatgacttt gtccaaattg cgcaaaagcg ctccgccgcc ggttaacact atacctctgt 2284861 ccatgatatc tgctgcaagc tcaggcggtg ttttttcgag tgtgctcttc actgcttcga 2284921 caattgtaga tacagtgtcg cgtagagcgt tagaaatctc ttttcctgta atttcaattg 2284981 ttttcggcaa acctgtgagc aaatcgcggc cgcggatttc catgttgtcg gattcttcag 2285041 gagcttctgc agatccgatt tccattttaa tcgcttcagc cgtacggtca ccgatcatca 2285101 gattgtacgt ttttctgatg tagttgataa tcgcgtcatc catctcatca ccggctacac 2285161 ggattgactg agacgttacg atgcctccga gggaaataat cgcaacttct gtcgtaccgc 2285221 ccccgatatc aacaaccatg cttccagtcg gttcccaaac tggcagattg gctccgattg 2285281 ctgcggcaaa aggctcttca atcggatacg cgtcacgcgc tcccgcctgt cttgtcgcat 2285341 cgataacagc gcgttcttca acagctgtaa tgcctgatgg gacacatacc attacatatg 2285401 gttttctggc aaacatgcct ttatttttta tggcctgatt gatgtaatat ttcatcatcg 2285461 tcgccgttgt ttcataatca gcgataacgc cgtctttcat cgggcgaaga gccaccacgt 2285521 tgcccggtgt ccgtccaatc atatttttcg catcatttcc gacagcgaca atcgatttcg 2285581 tatccgtctg caaagcgaca actgacggct ctctcacaac aattcctttt ccttttacaa 2285641 aaacaagcgt attcgcagtt ccaagatcta taccaaggtc tctagcacca attccaaaca 2285701 tatgtatgta tcttcctttc ttaaagcaaa aataccctaa agggaaaaac tcataaactc 2285761 tattatagct taattcgacg aaaaaaaaag tgttacaaat atcctttttc ctttaaactc 2285821 acaaattttt tatccccgat caccaaatgg tcaagcagct cgatgccaat caggtttccg 2285881 cattcaaaca gccgtcttgt cacttcaata tcttccctgc tcggcgtcgg atctccagaa 2285941 ggatgattat gaacacagat aaaggaagcg gcagatcgtt taaacgcttc tttaaacacc 2286001 tctcgcgggt ggacaataga tgaattcagg cttccgataa atacggtgcg tttatggatg 2286061 acttgatttt ttgtatttaa gtataaacag acaaaatgct cctgggttaa aaagcgcata 2286121 tcctccatga caagattagc gccgtcttcc ggggagcgaa taacgaaatg ttcttcgttg 2286181 gctaatttat gaatccggct tccaagctca actgctgcca gtatttgaat cgcttttacc 2286241 ataccgattc ccgggatgct tgacagctct tcaaccgatg cttccttgag caggcgcagc 2286301 ccgtcaaatg agcgcagcag ccggtttgac aggtccaaaa cagattcgtg tttagtccct 2286361 gtccgcaata atatagccaa aagttcatga ttcgctaagt tctcggctcc gactttcagg 2286421 agccgttccc ttggcttttc tttcattggg aaatctttga gttttaatgg cagatcgtgt 2286481 atgaccaagc actccttttc tttcccttcc cgtttataga accgtcatgc ccttatatca 2286541 aaatggcgaa gagctctcat tgtttttgat ataggaaggc ccatgactga ataataatct 2286601 ccgtctattt tctttacaaa aagcgcgcct cttccttgga tgccgtatgc acctgcttta 2286661 tccatcggct cttttgtttc aatatatgtc caaatctctt cttcactgag ggaccaaaac 2286721 gcaacttctg tcttatcata aaaagtctcg ctgtgatttt cagcttgaat gctgaccgcg 2286781 gttattactg agtgacttcg gcctgaaagc ctccgcagca tagaagcagc ttcttcttga 2286841 tcctgcggtt tgccaagaca ttcgccgtca aggcatacca ttgtatcagc accgataacg 2286901 attgcatgcg ggtggagatc agctacagcc ttagcttttt gttttgccaa ccattggacg 2286961 ttttcttctg gtgaaaagtt tcgatttaat ttttcttcta cttcactgac aataatggag 2287021 tagggcagct ggagaagatc gaggagttct ttcctgcgcg gagattgtga tgcaagtatt 2287081 agcggttttg tcatgttcgt catcctttca gggtttgctt aagaaaaaaa gatactcgtt 2287141 tatcctacca aatcacgagg cttgtcacaa tttcagaaaa ataacttttt catgacaaaa 2287201 taaaaaaagc ctgtcactaa aggacgaagg ctcagggcac tatctcttat tttacgacgg 2287261 ctaacagctc ctgctgagcc ttccacccgg cttcagcact tggatcctct aattccttta 2287321 aagcctgcaa aatcgctttt ttctctcctg tttctgacgc ttttgtttca ccaagcgact 2287381 tttctatttt ctctacactc gcttttgtaa tgtcttcgtc gagaatcgcc tttgctgcaa 2287441 gctccgctgt ttccttaaaa gaatctgtca tatctgactc tattgataag gaaagctcct 2287501 tgcctcccca ggcttcaaaa tcactgtcga ttaaaacctg tcctaactgc tgtgagacct 2287561 ccttttcact tgctaagcct gcaataacat acgtataccc gtcatccttt gacagtgaca 2287621 cggcggaata tcctttttcg gtcaattgtt ctgttaacgt ttcggcgccc ttttcatttg 2287681 aaaattttcc ggcttgcaca gcgtatgttt tgtatgtacc ttcagtttgt gccgcttgtt 2287741 tttctgcgcc tgaggtttgt ttatcagcag aagtatcccc tgcttttgcc gtttggctgc 2287801 ctaaagaatc ctctaaagag gccggtgctg acgcttcttt attccccgat atgtttaacg 2287861 cgaataaccc taatccagtg ccaatgacag ccgcgaaggc aatcgtcgcg gccactcttt 2287921 ttaccggttt ggcagccccg gtctttcctt ttgcgtaaag ctttgttttt ttcttttgaa 2287981 aaggaggaac aactttaggg tcctctttaa acaccttgtc ctcctcggaa tcccaattga 2288041 attcatcttc atcagggtgt tcctgggatg ccgcaacctc ttgttctgcc tgtctttttt 2288101 cctcccaatt tgaaaatgtc atgcttttat tcgcctctgt ctcaggcgtc tcttgttcgt 2288161 aaaccgtctc ttcttttcca ttaatcgtca ccttgagggc tttttctgcg gctttactgt 2288221 tttttttatt ctttcttttt ttcaattccg cttcctccct tcatttgctt gaccgttctt 2288281 gtcggctttt catgctacac actttagcac aggcaaagaa aaaaagaaca agacttttgt 2288341 cgccttgtcc aaaaaacgtt cgtcaaattt ttcagcagtc agcccaatgc cattttgata 2288401 taaaaagaaa tgatagagtc accgtataaa taggctaaaa tgctccctgc ggctatagcg 2288461 ggggcgaagg gaagcggctg ccttttagcg agtctaccag tcagaacagc tgccgctcca 2288521 tataatgcac ctatcaaaac tgaaaagaaa aaggcagctg ccagcatttt cacaccaagc 2288581 acaaagccaa tcaccgcaaa taatttaata tctcctcccc ctactccccc atgggtgatt 2288641 gcggcaatta cagccagaaa caaaaatccg gctgccgcac ctaacaggcc tgcataccag 2288701 gaatcaagcg gagaaatcaa tctcgcggcc gccaaaaagg gaagaaagaa aatcaatatt 2288761 cgatttggaa tcagcataaa atgaatatct gtcactgcaa caataatgag aagagagata 2288821 aacaccacag cgggaaacag ttccagcgat atgccaaagc gtattcctgc ggcggcaaat 2288881 aaacacgctg tcacaagctc tgctgcggga tacataaaag aaatcctatg cccgcagctt 2288941 ttacatttac ctttttgaaa taggaatgac aggatgggaa ttaattctgc aggagttaat 2289001 gttcgccggc aaaacgggca tgatgaacgg ggcgcaataa tagatagatg taaggggata 2289061 cggcacccgg ccgtatagta aaaagaacca aggataagcc cgaagataaa aagaatggat 2289121 agcatagaca acacaccttt actcattgag ttctggtatg gattgtagca aaatggacat 2289181 cctgagctcc aattgggaat attcaatttt acacatgaaa aaaacggcag aatctttttt 2289241 tgattctgcc ggagccggat gcttttattt caaccttttt cgaatgtcag aaataaagta 2289301 aagagatccg gtaatcagca caatttcatt tgagcccttt ttactttcta tgaatttgat 2289361 tacatcgtct ggatcttcac tccagctttt attgctgatt tcacttgcat catagagatc 2289421 ttttgcaagg gaagcacgcg ggaaatcaaa agaagcaaaa tgaatcgcat gagcaatggt 2289481 ttccagtctt ttaatcatgt tctgatacgg tttgtccttt aacgcgctaa acaccacaga 2289541 aatgcgtgaa ttggcgaaac gctgcttcat cgtttccgcc agcttttcaa caccttcttc 2289601 gttatgcgca ccgtctaaat ataccggagg atgttcctga acaagctcta accgtcccgg 2289661 ccaagcagcc ttcacaagcc cgctccttaa cgcttcgtca ctgatatggg cgatattctc 2289721 cttattgagc cactccgcag ccaaaatgga caaagcagca ttttgtcttt gatgggtgcc 2289781 aatcagagat gtccgaatat cttcatagca tttctcttcc gttttgaatg aaaactgttc 2289841 tcctgcaggc agagcctctt cattgaaaat aacacatgca tcatgcaatg actggaacgg 2289901 cgcagcatgc cgttcggctt catggcggat gacctgtaaa gcttccggct gggtaactgc 2289961 tgtaacgatt ggaatacctt ctttaataat gccggccttt tctcctgcaa tttcttcaat 2290021 ggtgtttccc aaaatgttca tatgatcgtg tccgatgctt gtaatcacag ttaagagcgg 2290081 ttcaaccaca ttagtagaat cgaatctacc gcccagacct gtttcaaaaa taacaaaatc 2290141 gaccttatga aactctgcaa aatataaaaa tgcacaagct gtcataattt caaattctgt 2290201 cggctgtccg tattccgttt gatcaagggc ttcaacgtgc ggtttcattt gattgacgag 2290261 tgctgtccat tcctcatctg aaatcggtat cccgtttacg ctgatccgtt cattaaacgt 2290321 aataatataa ggcgatgtaa atgttccaac cgtatatccg gcttcctgca gcatagaacg 2290381 gataaaagcg acagttgatc ctttaccgtt tgttcctgcg acgtggaacg ctcggatttt 2290441 tttttcagga tgtcctaacc gcgccatcag ctgtttcatt cgaccaagtc cgggcttcac 2290501 cccgaatttc agcctcccgt gaatccagct gcgcgcatct tgatatgcag taaacaatga 2290561 taatcccctc ttttataaga caaggcggtt tctctagaaa ccgccccggc ttttcattaa 2290621 cccttcagct cagccattcg tttttgaaca gcgtcacgct tcgccacata atctttttct 2290681 ttttcacgtt cttcatcaat tacgtgtgca ggcgcttttt tcataaatcc ttcatttcca 2290741 agtttctttt ggacacgctc aacttctttt gtcagtttat caaattcttt ttgcagacgg 2290801 gcaatttctt catcaatatt gattaagcct tcaagcggaa gaataacctc tgctcctgag 2290861 acaacggccg tcatcgcctt atcaacagcc tcaatatcgg tgccgatttt aagcacgctc 2290921 ggattcgtaa agcgttcaac atatgaacgg ttcgcttcga ggcgggacgc tatttcgtct 2290981 gtgcttgttt taatgtacag ttcaacctgc ttgctcattg gcgtattgac ttcactgcgg 2291041 atattgcgca cagaacggat cagctcaaca agaagcttca tgtcagctgc cgcttcagta 2291101 tcggtatgct ccggcactac tgcaggccat tgacttactg taatcgattc cccttggtga 2291161 ggaaggtgct gccaaatttc ctccgttaag aatggcataa acggatggag cagacgcatc 2291221 gtttgatcaa gtacgtaagc aaggatggaa cgggtagttt tcttagccgc ttcgtcttct 2291281 ccataaagcg gaagcttcgc catttcaata taccaatcac agaaatcatc ccaaataaag 2291341 ttatataaat ggcgtcctac ttcaccaaat tcatatcggt cagcaagctg ggtcacgtgc 2291401 tcgatcgttt catttaatcg cgttaaaatc cacttgtcag cgactgactt ttcacctgac 2291461 agatcaagct catcgtacgt catgccatcc atattcatta atgcaaaacg ggaggcgttc 2291521 caaattttat tggcaaaatt ccaggtcgat tccacttttt catagctgaa gcgcagatcc 2291581 tggccaggag agcttccagt cgcaaggaaa taacgcagag aatcggctcc gtacttgtca 2291641 atcacatcca tcgggtcgac accgttgcca agagatttac tcattttccg gccttgctcg 2291701 tcacggatta agccgtggat taaaacatct ttgaacgggc gctcgcctgt aaattcaatg 2291761 ccttggaaaa tcatgcgtga tacccagaag aaaatgatat cgtaccctgt cacgagaaca 2291821 tctgtcggat agtagcgttt aaagtcttca gccgttacat caggccagcc cattgtggag 2291881 aaaggccata gcgcagaact gaaccatgta tccagtacgt ctgtatcctg ttcccaattt 2291941 tcgctgtctt ccggcgcttc aagtccgaca tatagctcgc ctgtttcttt atgataccag 2292001 gcaggaatac gatggcccca ccacaattga cgggagatac accagtcgcg gatattttcc 2292061 atccagtgta aatacgtttt ttcgaaacgg tcaggcacaa agttgacctt ttcttctttt 2292121 ttttgcagct caatcgctgc atcagcaagc ggctgcatgc gcacaaacca ttgtgtagaa 2292181 agataaggct ccacaacagc cccgcttcgt tcactatggc cgacagagtg catatgatcc 2292241 tcgatcttga agagaactcc cgcctcctgt aaatctttca cgagcttttt gcggcattca 2292301 aaacgatcca taccttgata ttggagcgca ttttcattca tcgtgccatc ttcattcatg 2292361 acaaggatgc gttctaaatt gtggcggttg ccaagctcga agtcgttcgg atcatgagca 2292421 ggcgtaattt tcacggcacc tgaaccaaat tccatatcaa catagtcatc accgacaatc 2292481 ggaatttcac gatttacaat cggcaggatc accgtttttc cgataaggtg tttatagcgc 2292541 tcgtcttcag ggtgaacggc aacagctgta tcaccgagca ttgtttcagg acgtgtcgtc 2292601 gcaatttcaa ttgagcctga accgtcagca agcggatagc tcatatgata gaatgcgcct 2292661 tgaacatcct tgtaaatcac ctcaatgtcg gatagggctg tttttgtcgc tgggtcccag 2292721 ttaataatat attcgcctct gtagatcagg cctttttcat aaagcttaac gaatacttcc 2292781 cttaccgctt tgctcaagcc ttcatccagc gtaaaacgtt cacgggaata atctaggcca 2292841 agacctaatt tcgcccactg gctgcgaata aagtcagcat attcttcctt ccacttccac 2292901 gtttcttcga ggaatttttc acggcctaaa tcgtagcggg atttgccttc ttcacgaagt 2292961 ttcgcctcca ctttagcctg tgtcgcgatg ccggcgtggt ccatgccagg aagccacagc 2293021 acatcatagc cctgcatgcg tttcattctt gttacaatgt cttgcagcgt tgtgtcccat 2293081 gcgtggccaa ggtgaagtct ccctgttacg tttggcggcg ggatgacaac agagtatggc 2293141 tcttttgtct ggtcactgcc cgcttcaaaa aatttgcctt ttagccaaaa atcatatcgg 2293201 tctttttcaa ccgctgccgg atcatatttc gtcggcattg tttgttcatt cgtttccatc 2293261 ataaccctcc agcatgttta aaaatggctg agaacgaaaa aagagctctt catccctgta 2293321 aaaggacgaa aagctctttc gcggtaccac cttttttcat gaactcaatc agttcatgca 2293381 cttataacgg ataacgggtg tttcccgaat ttctctactc ttctttcaag aaattatgct 2293441 cccgggcgac cttccaatca gacaacataa gaagcctttc agcaaacggc ttctctctct 2293501 gcatgcgcct tttttgtact cttcccgttc taagcaggtg tatttatcag ctcattgtat 2293561 acattattta tgttctttat tatagtaaaa gtgtttttga ttcgtcaatc atcttttcca 2293621 aaaacaccgc tttctataca gatgggcagg cacctattgc ccaagtttac atatgatgct 2293681 tgtaaatgcg tagaggagga tgcaccgtga agaaacgttt cagctcttat tcgctgccgc 2293741 catgggtaag gcaaattcgg cttgtatccg cacaagtgat tattcccatt acgatttttc 2293801 aaggaatcag aaccattttc tttccgacaa cctttgatgt tttgctgctc gcaatcctaa 2293861 tctttttagc ttgcgccctt catttagaat ggatataaac aaacaagtcc gcgccattaa 2293921 gacgtggact cgttttcagc ctgaaatttt ttctcttgtt caatctgatg aattttcatc 2293981 acaaacggct ctatgttttt catttgccaa taagccttta ataattgtgt acattcctct 2294041 ttttcatgct gtcttttccc agtttgataa ccgttcagca ccttgtacat ggctgccgga 2294101 tatgccatat agctgagaaa aaggctgact tccgcttcac gcaaagggaa tgatttcgta 2294161 tatccataaa accattcgac gcattccgga caagctttcg gaaagcctct gaacattttt 2294221 gtataaaagc cgagcaggtc gttttgcggc ggaccgacag atgctctttc gaagtttgta 2294281 aaatatccgg tcccggcatc attatacaga aaatggtgta tagacaggct gccgtggttc 2294341 attacaaccc ttgaaacgtc cttttccttt gcggactcat accagtcctc cagccgttcc 2294401 agcgcaaagt tcaccgcgga aatggtttca gaaaaatagg ttatggcctg gagttcaaag 2294461 ggagaaaggt accattcctt ctccgctcta tccacaaact gctcatagaa aattttatct 2294521 tgttcccact tttttttcgt ttgcccgtaa taacgttcaa tctcatcacg tctaaccttt 2294581 agttcctgcg cggttctctc gtgaagacgg gctgtttctc taaataaata agcatgtttt 2294641 tgatcccgtt cttcctcttg gtcaaattgg agccaaggca ttaaatagta gatatctccg 2294701 tattgtatgc ctgctgagaa aaactcaccg ctatttgttc tgtaaacggg aacgaatgaa 2294761 cgaaagcctt tttcctcaat cgccaccata tgatctgtaa aatgcttgcc gcgaccttct 2294821 ttcaattttt tcagggcaaa tatgccgtag tctgtataca ctttccaaac aagaggactg 2294881 acaggctcaa taaattgagc agtcagtccg tattcctgaa gaaccgattg ggtatcttcc 2294941 atttcattca ccacattttc cgatcactta cggtttacgc atggctattt ttatattgag 2295001 gaatatagag aatctgtcct gcttttaatt catcatccaa ggctaaagaa ttcatcctga 2295061 tcagctgctg ggatgtaatt tcataccgtt cgcataaacg ctcgatcgta tcttcctgct 2295121 gcacaataca aattttcatt ctcgaaaact catccgcttc ttttgtaaag agttttgtta 2295181 aataaagaga attatcactt tcctttgttt gaggttcctt cgtttcagca gcaggagcaa 2295241 ccctaggaac agcatccgtt tccttccttt cagtctcaga agattcaggc agctggaagg 2295301 attgaaaagg tgtttcttcc ttaggctctt cagctgatgg tgtttttctc acttcaattt 2295361 cgaagctctc ttcctcttgt tcttcctcct ccagcagctt aggcgctgaa taaaaagaat 2295421 cctcctcttc ttgttcaggc aggaaggtac ggtatgccgg ttcaggcaat tcttcttgag 2295481 atgcctcctc cgagcttgtt ttttgattga aatggaaatg taaatcggca ttgtcattct 2295541 ccatatatac agctgaagct gtttctctgc tatcttctat ggagagagcg gcctctgata 2295601 cactctccaa agcttcatcc ggttccgcct cttcttggca aagcgcagga tcagcctgat 2295661 ccgattgagc tgcttcttca ttttgagcct cttggcgcag cgcatattca tgattaggag 2295721 acactgttgt ttcctctttt tcctttgcaa tcacagtctc tgaatgaagc tcagcttcca 2295781 aagcaggcga ttcttctgct ccaacgtgtt cacgaagctc agtctccgct ggagagtctg 2295841 cttcttcacg aacatccgct attgcagctg ccggctctgc cgtttctttt tttgctttaa 2295901 cgatctcttg aatctctatt tctgaaggat caggttctgg ctcagattct tctgtttccg 2295961 attcagcacg aacctccgtt tccggcacag caagctcttc tgactcttct tcctctttca 2296021 catcttctct ggcctctggt tctgaagcaa ccgattcagg cggctcagat tctgcttttt 2296081 ctgtctccag ttcttcacgg agccccgctt tcgagataaa aagttctggc ggttcggctg 2296141 gcggttcatg ctgaagaact gcttcctctg ccgatgatgc acccggttct tctactacac 2296201 tatgtgccgg cggctctgaa agctcttcct ccctgaatgc cgcaggagct tcatataaag 2296261 gtatctccgg ctctttgtct tgcgtatcgt ccaaaagccc ttcgatcgct aaatcagctt 2296321 gaattgttaa aatgcgcgaa tccgtcaatt gatagtcaaa tgcgtcaata aagacgaaga 2296381 catcctgtaa atggctcact ttatttttcg gaatggtaat atccacagga aaacagtgag 2296441 tcagttccgc acttccatcc tctctctttc tgacttgttc aacaaaccgc ttatctgtat 2296501 aaatctcttc ggtatgtttg ttttgatcta tgttgtactc acctgtaagt tcaagcgatc 2296561 ctatgattga tacataatca tttacttcct gaaccctaat atcaggatct aatgaaatag 2296621 aaagcagttc agaaacttcc tgtccttttt ggaaacagat cgattcttct acagaaaatt 2296681 gcaatcgatg attttgcggc aagttcatat cctcctttca tctaatcctt aaaattagat 2296741 gtcactaaag gtgtatgtat gaactggaga aaatatgagt gggagagcac gaaaaaaccg 2296801 gcacaaggag tccttgatac cggttttcac tcttatctgc ggctgatctc agcaaatact 2296861 ttctcagctg cctggattgt gttttcaata tcttcatcag tatgggccgt tgagaggaaa 2296921 agaccttcga attgtgatgg cggaaggaat accccttcat ttgccatccc tttataatag 2296981 cttgcgaaca gcttcaaatc agatgatttc gctgtttcat aattgatgac tggttcgttt 2297041 gtaaagaaga aaccgatcat cgaacctgca cggttaaagg tatgcggaat gccatgagcc 2297101 ccggcggttt ttgaaattcc ttcttccagt ctgtcgcctt ttttgatgaa attcttgtag 2297161 gattcaggtg tcagctgttt caatgtctct aagccagccg tcatcgcaag cgggttgcct 2297221 gacaatgtac cagcttgata gatcggaccg cttggagcga tctgctccat gatttctgcc 2297281 tttccgccat aagcgccgac aggaagtccg cccccgatta cttttcctaa acaagtcaga 2297341 tcaggcgtta cgccgaagta gccttgagcg cagttataat cgacccggaa gccagtcatc 2297401 acttcatcaa aaatcagcag ggagccgtac tgctcagtga tatcacgcag accctgaagg 2297461 aaaccttctt gcggcggaac aacacccata tttccggcaa ctggctctac aatgactccc 2297521 gcaatgtctt caccgaattg ctggaaagca agctttacac tttctaaatc attgtacgga 2297581 acggtgatgg tgtttttcgc aatgccttca ggcacccccg ggctgtcagg cagaccgaga 2297641 gtggcaacac ctgaaccagc tttaatcaag agagaatcgc cgtgtccgtg gtagcagccc 2297701 tcaaatttta aaatcttgtt gcggcccgta tagccccttg ccaaacggag ggcactcatt 2297761 gtagcctctg ttccggagct taccattcgt acaatttcta cagatggcac acgatcaatg 2297821 acgagcttag ccagttcatt ttctacttca gtcggagcac caaagcttgt cccgtattca 2297881 gccacttttt tgaggctttc tacgacgcgg tcatttgtat gccctaaaat taaaggcccc 2297941 catgacaaga cgtagtcaat atattcattc ccgtcaatat caaagatttt cgagcctttt 2298001 ccgcgctcca taaaaatcgg gtccatgtct accgatttaa atgcgcgaac gggactgttc 2298061 acaccgcccg gcatgagttt ttgcgcttct ttaaaagccg tttttgattt ttcatagctt 2298121 ctcatctgcc tcaactcctg tcaactgaat aaaattactc cgcaagccat ttcgctgcgt 2298181 ctttcgcatg atacgtaata atcaggtcgg cacccgcgcg cttcatgctt gtcaaaattt 2298241 ccaacacaat ttctttttct ttgatccagc cgttctgcgc tgcagccttc accattgaat 2298301 actctccgct tacattataa gcgacgagcg gcaaagtaaa ctcatttttt acgtcacgca 2298361 tgatatccat ataagaaagc gaaggtttga caatcaaaaa gtccgcgcct tcctcaacat 2298421 ctgattgtgc ttcgcggagt gcctccatac ggttggcagg gtccatctga tatgttttgc 2298481 ggtctccgaa ttgcggtgtg ctgtttgctg catcacggaa cggaccgtaa aactcacttg 2298541 aatatttaac agcgtaagac atgatgggaa tattgacgaa tccttcttta tcaagtgctt 2298601 ctctgatcac tgtaacaaat ccgtccatca tgtttgatgg cgcaatgata tccgcacctg 2298661 ctttcgcttg gctgacagct gtctgcgcca aaagctccag cgattcatca ttgagaatga 2298721 ctccgtcttt gacaagtccg caatggccgt ggtctgtata ttcgcacagg cacgtgtcag 2298781 cgacaacaac catttcaggg aagtgttctt taatttctgt gatggctttt tggacaattc 2298841 cgtgatcatg gtacgcttgt gttccgcaat catctttttc ttccgggatg ccgaacacga 2298901 taacagattg aatgcccagt ttgaccagct ccgctacttc atccttcaat aaatctaatg 2298961 atacatggtg aacatcaggc attgacggaa cagctttttt gccttccagc ccttcaacga 2299021 caaaaatcgg atatataaaa tctgatggat gcaaacgtgt ttcctttacc atttctctca 2299081 ttgcttttga tgtccgcagg cggcggtgtc tattaaatga ttgactcata ttctctcttc 2299141 ctctcttgac atgctgcaca ttaactcaag catgccatct attgtaaatg tatcaggcgt 2299201 atgcgatgtg atgccgtacg tcagaagggc atcatttgtt aaaggcccaa tgctgataca 2299261 ggccgtccca ttcgccttcc acttttttaa ttcttctccc aagacatgca taaacgtatg 2299321 tacggttgat gaactcgtaa atgttacata gtcaaaggaa tattgacccg cagcgtcttt 2299381 caatgcctca atgccttctt catccggaat cgtttcgtag agaacccatt cctttacttc 2299441 aaaaccgagc gggacaagct cttgttttat cacatcacgt gacaaattcc ctttcatcac 2299501 ggtaatggtc tcccccggtt cagcatgctg cttaagagcg tcagccaatt gttcagcaat 2299561 atactcctgt ggcatcacat caaccgatac gttatgcatt tttaaacggc gcgcggtttt 2299621 ttcaccgacg gctgcaattt ttttatgcgc agggagaata agctgatttt ccttcagata 2299681 agaaaaaaag aagtctgccc cgttcacact tgtaaaaaca agccagcctg gcgcggcaag 2299741 atcctctctt acctgttccg caacatcatt cggcaaagcg cggcgaaacg taatcaaaga 2299801 ggttaaaacc gctttaccgc caagcgcctc cactttttgc tgaaatgatg ctgcctgtgc 2299861 cttattccgg gtgacaagca ctgtttttcc tttcaacgga aaatcatttt ccatcctcgt 2299921 caagctcccg ttttacacga tcaattaaat cttttgctcc tttgtcagcc ataagagcgg 2299981 cacagcgctt tcctacttcc tccggatcgt ttccggtgac ggtttcttta aaaatgattt 2300041 tgccgtcagg tgaagcgaca agacctgtca tttcaatttc atcctgtcca tttaacacgg 2300101 agtagcccgc gatcggaacc tggcagccgc cctccatcgc gtttaaaaaa gcacgttccg 2300161 ctaagacagt ccgttttgta tattcatctg taaactgaga aaacaacgcc aacagctctt 2300221 catccgattc tcggcactca atcgccaggg ctccctgccc cacagcaggc aaacagcgct 2300281 caggctcaag gaattcggtt acgacatctt gcttccaacc cattctggaa aggccggcag 2300341 ccgctaaaat aattgcgtca taatcctctg tttccagctt ttgaagtctt gtatctatat 2300401 tacctctaat ccatttaatt gtaaggtcag ggcgctcaat caaaagctgc gcgcttcttc 2300461 ttaaactgct tgtgccaatg acagcacctt tcttcatttc tgaaagcttt acgcgattct 2300521 ttgaaataag ggcatcacgc gggtcctccc gttcaggaat acagccgatc acaaggcctt 2300581 caggcaaaac agcaggcatg tccttcatgc tgtgcactgc catatcaatc tcttcgttta 2300641 aaagcgcctg ttcaatttct ttgacaaaaa gcccttttcc acccactttt gagagtgtaa 2300701 catcgacaat ccggtcgccc tttgtcacga tctctttaat ttcaaaagca aacgaaggat 2300761 tgatttcctt cagtttttga ataacccatt ttgtttgagt catagcgagt ttgctccgtc 2300821 tggaacctac tttaatcgtt ctcatcattt ctttcctccc gaatctgctt gggacatcgt 2300881 ttaactgaac caatggaatt gcgacaggct tccaagcagg aaataattga tcatcagcac 2300941 cagaaaacaa gccgtattcc acagtgcagc gacctttcct tgcagctcct taatcagcct 2301001 gatataaaga taatagctgt acagcagcag gacgacaaac gaaccaagca ctttggcgtc 2301061 aaaccaatac agcgtttcta gtgagacata cgcccaaatg acgccgagaa tcaaactcag 2301121 cagcagcatc ggaaccccaa tgacatttaa aacatacgcc atataatcaa gcttagataa 2301181 atcttctatt ctcaacagcc attttcccca ctttttcttt ttcagcagat gatattgaaa 2301241 catatatagc acagaaaaaa cgaaagaaag ggaaaaagcg ccgtatgaaa gaatcgccat 2301301 tgtaatatga atcaccaaaa gctcggatac aagctgcccg gaaaaagcag ctgactgctg 2301361 ctctgtcggt gaaaatgtgt gaatggcgat catagaaaat cctataacat ttgtaaaaaa 2301421 cacgataaag tcaacacgta aaagctttgt cagtacaagt gacagcgtga caagcaccca 2301481 ggcataaaaa taaagtgcct ctgtcacatt taataccgga aaccgccccg tcacccacat 2301541 aaaataggcc aaatacacgg tttgcagagt ccagacaata gaaagcaacc agaaggccat 2301601 ttttccagcc ttccggttgt gttgaagaaa atctataaaa taaaagagta cacttaacgc 2301661 gtaaatgacg attgtcccct cattaagtct tgccattgca gtatcaatca ttcagctttc 2301721 actcacttac aagtgggcta aagcccgctt ttgattcagc cttcttaaaa gagtggacct 2301781 tctggctgct ttcaacggtt ttcatcattt gacggcccgc agcttcttca atatcaaaaa 2301841 tctgcataaa caacgcgagc ttttcttcag aatcagcatc tgccgcaagc tctttcacct 2301901 ttaaaatcgg atcacgaagc atttggttaa taatactttt ggtgtgtttg ttcaacagtt 2301961 ttttctctct tgtgcttaag tgaggcagct tacgctcaat gctgtccatc gtttctgact 2302021 ggatggcaag cgccttttcg cgcaatgcag aaataacagg cacaacacca agtgtattca 2302081 tccattgttt aaattccaca atggtttctt caattaacag ttcaactttt tcagctgttt 2302141 ctctccgctc tttcatgttc gcttctacaa tgccttccag atcgtcgata tcataaagaa 2302201 aaacaccttc aagatcattc agcgccggat caagatctct aggcacggca atgtcgacca 2302261 taaacagcgg acgtcccttg cgaagcttat tcgcgttttc catcatctct ttggacacga 2302321 caaattcact tgcaccggtt gaactgatta aaatatcagc ctccgcaagc gcgctttcaa 2302381 gctgattcaa gcttctcgct tcacctgaaa aacggtctgc aagctccttc gctttcaagt 2302441 atgttcggtt aatgacagtg accttgccga ttccctgtcc gtgcaggttt tccgcagcaa 2302501 gctcgcccat ttttcccgca ccgagaatca atatgtgctt gcttgaaaga tttccgaaga 2302561 tttttttggc aagttcaact gcagcatagc ttactgacac cgcatttgag ccaatgtctg 2302621 tttcggcgtg agtccgtttg cccactgtaa ctgcctgctt aaacagctca ttaaaaatag 2302681 tcccgatcgt tttttcttgc tgagctgttt taaagctgtc gcgtacctgt ccgagaatct 2302741 gcgtttcgcc aatcaccata gaatcaagtc cgcaggctac acggaataaa tgctcaacag 2302801 cggcatcgct ctcataaaac gttaagaacg gtgacagctc ttctttgctt aattgaaacc 2302861 aatcagctaa aaactttttt atataataac ggccggtatg aagctggtcg actaccgcat 2302921 aaatttcagt gcggttgcag gttgagacaa tgatgttttc aagaatgctt ttctcttctt 2302981 tcagctgcac cattgcttct gccagctcat tcggctgaaa acttactttt tcacgtatct 2303041 caataggggc ggatttataa tctactccca caacaagtat atgcatcgct ctaattacac 2303101 ccccaacacc caatcttaat ttataatcat tctaacatag aactcattat ttataataat 2303161 tataacatag tttctttcac aaaatgtgaa cagattttaa aattcttatg ctatattaga 2303221 aaaagcttca gggaaaagaa gcattcctat tgacaatacc aaaaacagca gaaatttact 2303281 acacatcagc tctaaaaaac aagaaggtga tatgcatgaa acaaaaatca attttattcc 2303341 cttgtctgct gcttgccgct tctgtatatg catggctaga aagcggccaa gccgaactgt 2303401 tttcagggca ggatcaatgg cctgttctcc tcatgctgtt aggcgcagcc tttgtatatc 2303461 aaggaaaaaa agaagccgtc acaccccatt tttttatcgg tttgcttctc ttcgggatcg 2303521 gtttacactt ttttgccaag ccgaaatggg tatggtggcc ggatgatttt gaaatgctcc 2303581 tctttatgat cggcttctca cttctcgttt caaccgttca aaaaaaagaa tatgtatatg 2303641 aagctgtgtc gatgatttgt ttttccctgt ttttgtactt tttcaaacaa attatggcat 2303701 ggcttgagtc tgcgcatatt ccaacagcgc ttctgaagga gtattggccg tttgtcttta 2303761 ttggaatcag tttattgtta ttattgataa aacgaaaaaa atctatacga taaataaaac 2303821 cggtagagga tcctctaccg gtttatcatt tttttgatcg ctccccaagc ttcgtctttt 2303881 ccctttttcg tttctgaaga aaagaggatc agctcgtctt ccggatcaat atttaatgtt 2303941 tgtcggacaa ccttcgcgtg tttgtcccat ttacctttcg ggatcttatc cgcctttgta 2304001 gcgataacaa taacaggaat gccgtaatac tttaaaaatt catacatctg tacatcatca 2304061 ttagatggcg catgccgcaa atcaacgatc tgcaccacag cttttaattc ctcgcgtgtc 2304121 gtgatatagg tttcaatcat tctgccccat gcttcacgct cagactttga cactttggca 2304181 aaaccgtagc ccggcacatc cacaaaatgc agctcatcat tgataatgta gaaattaagc 2304241 gtttgtgttt ttcccggctt tgatgacgtt ctcgcaagat ttttgcgatt gattaatgaa 2304301 ttgataaaag acgattttcc tacgttcgat cttccggcca atgcgatttc cggaagcccc 2304361 ccttcagggt actgttccgg ttttactgca ctgatcacga tttctgactt tgtgactttc 2304421 atttcttctc tcctactaag gcatgttcca aaacctcgtc taagtgggac gccaatataa 2304481 atgtcagccc ctccctgacg ctttccggaa tatcctctat atctttttca ttatctttag 2304541 gcgcaataat ggtcgttaat cccgctctat gtgcgccaag cgctttttcc tttaagccgc 2304601 cgatcggcag cacgcgcccg cgaagcgtga tttccccagt catgccgact tcacgcgaaa 2304661 ccgcccgtcc cgttaaagca gaaacaagcg ctgttgccat cgtaataccg gctgacggac 2304721 catcttttgg caccgcaccc tctggtacat gtatatgaat atcatacttc tcatgaaagt 2304781 caggttcaat gccaagttct tctgttttgg atcgcacata gctgaatgca gcctgagcag 2304841 actctctcat aacatctccg agctttcctg tcaggattaa tttccctttt cccggtgaaa 2304901 gcgatacttc aatcgaaagc gtatctccgc caacggttgt atacgcaagc cctgtcacta 2304961 caccaacttg atcctctgtt tcagcttgtc catatctgaa aatgcgtttt ccgataaaat 2305021 cttgaaggtt cttctcagta accgtaattc gttttcgctc ttcagcaaca atggcttttg 2305081 cagctttacg gcaaattgcg gcaagctggc gttcaaggct tcttacaccc gcttctctcg 2305141 tatagtaacg aataatatca agaatcgcct gatcacgcag ctgaagattg cttttcttca 2305201 gcccgtgttc tttgatttgc tttggaagca agtgatcctt tacaatttca agtttttcta 2305261 tttctgtgta gcctgcgata ttaataattt ccattctgtc tctgagcggg cccgggattg 2305321 tggccaaatt gttcgccgtt gcgataaaca gcactttgga taaatcaaag gtttcttcaa 2305381 tatagtgatc actgaagctg ctgttttgct ctggatcaag cacttcaagc atagcggatg 2305441 atgggtctcc tctaaaatca gatgacattt tgtcaatttc gtctaataag aagaccggat 2305501 tcagcttgcc cgcttttttc atcccttgaa taatacgtcc aggcattgct ccgacatagg 2305561 tccgtctgtg tccgcgtatc tctgattcat cccgaactcc tccgagtgag attctgacga 2305621 atttgcgtcc caagcttttt gcaattgatt tggctaaaga cgtttttccg acacctggag 2305681 gtcctgccaa acagagaatc gggcctttca gggattttgt cagcttctgg acagccaaat 2305741 attctaaaat acgttctttt actttttcaa gcccgtggtg ctcttcgtcc aagagacgtc 2305801 ctgcttcttt caaatcaagc ttatcatctg tttcatccgt ccacggaaga gcaaccagcc 2305861 agtcgatata gttgcggatc acagagcttt ccgcagaact tgacggaatt ttttcatatc 2305921 tgttcaattc tttaagcgct gtttctttca catgatcagg catgcctgct tcttcgattt 2305981 tttccgtcag cgtctgaact tcgccagttt tgccttcttt atcgccaagc tctttttgga 2306041 tcgccttcat ttgttcacgc aagtagtatt ccttctgcgt acgctccatc gaacgtttga 2306101 cgcgctggcc gatttttttc tcaatctcca gcacttcttt ttcattatta ataaaatcaa 2306161 tgaccttgtt cagcctgtct ttgacatcag ccgtttctaa aatatcctgc ttatccttta 2306221 gtttaagggg cagatgagaa gcaacgatgt ctgccattct ccccggctct tcgatatcag 2306281 taaccgcagc gtacgtttcg gccgagattt ttttagaaat ttttatgtac tgatcaaagt 2306341 ggtctagcaa agtccgcatc aatgcttcgt cttctgtatc ttttgaatca tcttcatgaa 2306401 taagttgaat gtcaaccgac gtgtaatcct cgtgttcatt gtatttgacg atatgggcgc 2306461 gcttgaggcc ctccaccaac acacgaatcg taccgttcgg aagcttcagc atttgcttaa 2306521 tttttgtata ggtgccgaca gtgaaaatct cgtcttcacc aggttcgtct atcgaaatat 2306581 cctgctgagt ggctaaaaat atcatatgat catgcatcat tgcctgttca agagcctgaa 2306641 ccgacttgtc acgtcctaca tctaaatgca aaaccatcgt cgggtacact aataaacctc 2306701 ttaaagggag gagcgggatg ctgcgtttta attcttctgc catgtgactg acacctccgt 2306761 gactttagta tgaaccatta taatacaact ttttcatcct tgtacaataa acggcatggt 2306821 tccattttct ataaaacagt ctcctcgtag tatacccttt ctttctgata tgaaaaagga 2306881 aaagatgtcc ttcatgaaaa aaaccctatt atcaaaatag ggtttaaacg gattctttat 2306941 tgatttcgat atgaaacggt ttttgttccg ttggcggatt caccaaaatt tcatcaagca 2307001 cttcttggaa cgtcttcact gcaataatct cgatcccgtc aatctgcttt aagatggcct 2307061 gctgattttc atatgggata atcacctttt tcgcaccgga ctgcttggcc gcttttattt 2307121 tcggaatgac gcctccgatg ggtttcacaa gaccgttcag gctgatttcg cccgtcatcg 2307181 caacggtatt gtcaatagga attttgtgta tcgccgagaa aatccccgcc gccatcgcaa 2307241 tgcctgctga cggcccatca atcggaatcc ctcctgggaa attgatgtga atatcataat 2307301 cagaaggctt cattcccatt gtccggagca cggttaatac attttcaacc gaacccttcg 2307361 ccatgctttt tcgcctgatc gattttgatt ggctgccgat gctttcttct tcagctattc 2307421 ctgtgatgtt aattgatcct ttatcttgag ccgcggttac acttacttcg atttccagaa 2307481 gcgatccgct gttaggccca tagactgcaa gcccatttac aatgccaacc tgtggttcaa 2307541 caccgatttt ttgctcgtgc tttggagtaa gctgactgga gtgaatgacc cattcaatat 2307601 cctcaatcgt aatgtccttt cgattctccg ttacagccat ccccgctgcg atttgaatca 2307661 tattgacggc ttcccgcccg ttccgcgtgt agctggtcaa aagatccagt ccttcttcgg 2307721 agatattttt ttcaatttta tccgctgctg ttttggcaac cgttttcagc tcgtcctttt 2307781 caagctcgcg gaaaaaaacc tccaaacagc gggaccggat agctggcgga atttcgtttg 2307841 gcattctcgt ggtcgcgcca atcaagcgaa aatcagccgg cagcccattt tgaaaaatat 2307901 catgaatatg attcggaatt tgtgtatttt cctcactgta atacgcactg tctaaaaaga 2307961 cttttctgtc ctcaagcacc ttcagcattt tattcatttg aataggatgc agctccccta 2308021 tttcatcaat aaacagcaca ccgccatggg catgggtgac agctccctgc ttcggctgcg 2308081 gaatcccagc ctgtcccatc gctccggccc cttggtatat cgggtcatgg acagagccga 2308141 tgagcggatc ggcaattcct ctttcatcaa aacgggctgt tgtcgcatcg agttccacaa 2308201 agacagcctg ctctttaaac ggtgattgtt tatgtttttt tgcttcttcc aacacaagcc 2308261 gcgcagcagc cgttttccca actcccggtg gcccatagac aatcacatgc tgaggatttg 2308321 gcccgcataa agccgccttt aatgctttaa tgccgtcttc ctgtccgacg atatctttaa 2308381 agcttttggg gcggaccttc tcagataatg gctcggacaa gctgatagcg cgcattttcc 2308441 gaagctgctc catttccttc tttgattctt tatctatcgt gaccttttgt gtcctttgat 2308501 ttttaagcaa attccaaaaa tacaaaccga tgatgatccc aaaaaacagc tgaataaata 2308561 acgcgatccc tgtccaactc atggtggtcc ctcctgaaaa acaatttatg tatccaattc 2308621 attcctctga ttgctagtat ctcccataga agacgggaat aaacgttttt ccggaagagt 2308681 tgcatgcaaa aaaacctcct gagtgttacc actcaggagg tttgtgctta tctttatgca 2308741 gatgttttat cttggcttac ctcagtgccg tcttttaata agaggcgagg aggctctccg 2308801 tgtgtcacag ttgccccggt gattacacat ttttcaatgt catcacgaga aggcagctca 2308861 aacatcacat caagcatgat gccttcaatg atagaacgga gtccgcgtgc tccagtcttg 2308921 cgttcaattg cttttttagc aatttcagaa agcgcttctt cttcaaactc aagctcaacg 2308981 ttgtcaagct caagcatttt cttgaattgc ttaacaagag cgtttttcgg ttttgttaag 2309041 atcgcaacca atgcttcttc gtcaagcttt tcaaggcttg caataaccgg aagacgtccg 2309101 ataaattcag gaattaaccc gaaacggagc aaatcttctg gaagcacttt tgaaagaaga 2309161 tcttctttct caagatcagc agctttattg tcggcaccga atccaatcac tttttggcct 2309221 aaacggcgtt tgatgatttg ttcgatacca tcgaaagctc cgccgcaaat gaacaaaata 2309281 tttgttgtgt caatttgaat gaattcttga tgaggatgct tacgtccacc ttgaggcggt 2309341 acgcttgcca ctgtaccctc aagaatttta agcaatgcct gctgtacacc ctcacctgac 2309401 acatcacgtg tgatagacgg gttttcagat tttctagcca ctttatcgat ttcatcaata 2309461 tagataatgc ctttttcggc tttttccaca tcataatcag cagcttggat gagcttcaag 2309521 agaatattct ctacatcttc acccacgtat ccagcttcag tcaaagatgt agcgtccgca 2309581 atcgcaaacg gcacatttaa aatgcgagcc aatgtttgcg ccagaagggt tttaccgctt 2309641 cccgtagggc cgattaatga aatattactt tttgaaagct caacatcatc aactttgctg 2309701 ttggagttaa tgcgcttata gtggttatac acagcaacag caagtgattt cttcgcttga 2309761 tcttggccga tgacatattc attcaaaatt tcgcgaattt cctgaggctt tggtacgtct 2309821 ttaaattcta cttcttcttc tgttccgagt tcttcctcta caatttcagt gcagagttcg 2309881 atacattcgt cacatatata tacaccaggt ccagctacaa gcttacgaac ctgatcttgt 2309941 gtttttccac agaacgagca ttttaattgt cctttttcct cgttaaattt aaacattctt 2310001 tcacccctta atcttgtctc actttttctt ttaccggcag agcaaaagaa aatgattctt 2310061 gaaacgaacg agtatgtatt gcattttacc atactttcca aaaagacggt aacaatgtgt 2310121 ttctgacttg cacattctat atgtatgaca aaaaacagcc ctgcattaac tatattgccc 2310181 caagaaaaag agataactca taattgtaca aaacaaggca cgaatgattc gcgccctgtt 2310241 ttattagtac tattattatg caccatatta acggttttct acaagaaaat caattgcttt 2310301 gcgaactttt aaatcttctt tcatcgcgtc agtagaaccg atggcttgtt taatattttc 2310361 aacaggcatg ttgtatgctt cagccatttt tgtaagctca gcatcaactt cctcatctga 2310421 tacttcaagg ttttccgctt tcgcaatcgc ctcaagagtc aggttagatt ttacgcgttt 2310481 ttcagcatct tctttcattt gctctttaag cgcagcttca tcttggcctg agaattgagt 2310541 gtaaagctca aggttcatgc cttgcatttg cagacgctgt tcgaattctt tcagcatgcg 2310601 gtcaagctca gtgtcgacca ttgcttgagg cacatcgatt tcagcatttt cagaagcttt 2310661 cagaacaagc tcttcacgca atttagcgtc agcttcgttt tcttttgctt cttctaaacg 2310721 tttctttgtt ttttcagtta attcagcaag tgtttccact tcttcatcga tatcttttgc 2310781 gaattcatcg tcaagctcag gaagctcttt cgctttgatt tcgtgaattt tcactttaaa 2310841 cacagctggt ttgcctgcaa gatcttcagc gtggtactcc tcagggaatg tcacttcaac 2310901 atccttctca gcacctgctt caaggccaac taattgatct tcgaagccag ggatgaatga 2310961 accagaacct acttctagag agtagttttc agcttttccg ccttcgaaag cttcgccgtc 2311021 aacgaatcct tcgaaatcaa gaacaactgt gtttccttct tcaacggcgc cttcttcttt 2311081 tacaacaagc tcagcttgac gctcttgaag ggcttttagt tcgttttgaa catcttcgtc 2311141 agttacagtt gtgtcgtctt tttcaatgcc caggcctttg tattcgccaa gcttcacttc 2311201 aggttttact gttactttcg cagtgaagat taagctttcg cctttttcga ttttttcaac 2311261 atcgatttca ggacggtcta caggctcgat tccagcttct tcaaccgctt tagggtattc 2311321 tacaggaaga agaatatcca aagcatcttg gtaaagagct tctacgccaa agcgctgttc 2311381 gaataatccg cgaggaattt tacctttacg gaatccagga attgaaactt gttttactac 2311441 ttttttaaat gcatcatcaa gtgctgtttt aaacgtttca gcatcaactt caaccgttaa 2311501 aacgccttcg ttgccttctt gtttttccca ttttacagac atgtgtttcc ctccaaaaat 2311561 ctattcaggt tgtgtcggtc ttccattcta aagcaatcat tcggcttcgt ccaacaaaaa 2311621 caaagctgcc aaagatcaga atcattatgt atagatgtta ataatgaact gcaaagcctg 2311681 tccaaccgta tttcttataa cccgttatac acaaatacaa ccactatatt ataacataac 2311741 acatagcgct ttcaactata tggcgcgatt tacaaataag aaatttcttc aatatctttt 2311801 aacattgtgc aagcttcatc gagttctctg tctgtaaatt catacatcat atgaagttct 2311861 tcgctttcaa tttcaatccc gtgcatctcg taaccgactt tatgaagggc agccgcccaa 2311921 aggtcagccg acagcaattt cggctggaac ggatataaaa cgtacaaatg tcttctccac 2311981 aattcttcta ctgctgcata taaggttgga ttttcatttc caagtgtctc atctagcacc 2312041 ctgagaacac ggtgaagaat cggcgcggca tcaggcggaa caatctctga cggttcaatt 2312101 gtcaacgact cgccaaattt actaatgtgt acaggtttac tgtactcatg ctcagccaac 2312161 agcatgacaa tcatcgtttt gataatcgga tgggctgagg ggtcttggag gattgttttg 2312221 agcaatcctg tatactttgc tacgttacgg tcttttaagg aatgaatgag attcatttgc 2312281 tcctcagggc ttgccagcac tttctcggtg tcaattgtat cctcatattc ttcggcccaa 2312341 gcctcgtcct cacgatccgg atcggtcatt ttccggctga aatccagcag cttataaaat 2312401 tgctcggcac tttctgccgg cagctgattt tcttccaaaa cggcttcaat ggtgcttttg 2312461 acttcttcgt actttttgag ctgaattaag atggtcatgt acacctgcaa aaccgtaaaa 2312521 taatggccat aaccttcttt gagcatcttc tcgcacacgc tttctgcctc ttccagctcg 2312581 cccagctcta aaaagcagat ggccatccct aagtgaagat cggattcagt atcatcatat 2312641 ttcatcgctt ctgaaaacag ttcaagcgct tcttgatact ttttttcctt gagtgatgac 2312701 atcccttttt ccacaaggcg gtctttcaga tgaggaaaag gaataatttt tgcgtttttc 2312761 ttgtcatgcg tcatacctat attcctttca ggcatttatt ttgttcaagt gtatcaacac 2312821 ctgtgaacaa aaacaagaaa tgaaaggttt caccaggcaa aaaaagccgc cggacaaata 2312881 ccggccgctt tttcaggctt gaagccaaga gcttctttgt gattcaaatt gcttgatttc 2312941 atcttccagc agcagcgtta atgaaatttc atcatatccg ttgatcagca tctctttcca 2313001 atgcggatca acttcaaatg aaatttgatt gccttcactg tcatgaatca gctgattttc 2313061 aaggtcaaca gtcatttgca atgactggtt ttcatactgg ccgacaagct gtttccaatt 2313121 gtcatatggc atgcggatcg gaagcatgcc gtttttaaag cagttctgat ggaaaatatc 2313181 agcgaatgac ggcgcaatga taattttaaa cccataatca tcaagtgccc acggagcgtg 2313241 ttcacgcgat gacccgcagc cgaagttttc tcctgctatt aaaatggaag ctccttgata 2313301 aacaggctgg tttaattcaa attcagggtt cggttcacca ttcgcatcat atctccagtc 2313361 aaagaatgca aaacgtccgt agcctgttct ttcaatcctc ttcaaaaatt gcttaggaat 2313421 aatctggtct gtatccacat tgatccgatt taatacggct gctttccccg tatgtgattt 2313481 caaaggttcc atctcgcgca ctccttacac aactgttttt tcctgataaa actttctgac 2313541 atcaacgaag tgtccgtgaa tggcagccat cgcagccatt gccgggctga cgagatgtgt 2313601 tcttgcacct tttccttgtc tgccctcgaa gttgcggtta gaggttgatg cacagcgctc 2313661 tccctcagga acaacatcat tattcatact caaacacatg ctgcagcctg actctctcca 2313721 ttcaaatcca gcttccaaga aaatctggtc aagcccttct ttttcagcct gaagcttcac 2313781 gctttgggat ccgggcacga cgatggccct tacgctgtca gctaccttct tccctttgat 2313841 catgtcagca gcctgtcgaa ggtcagtcat gcgggaattt gtgcaggaac cgataaatac 2313901 gtgctccact ttaatgtctt caattttttg gtgaggagtc aatcccatat attcataagc 2313961 acgaatcgct tcttttttat cgtcttctgc agaaaagctt tccggcgcag gaacttcaga 2314021 atcgacagga agaaccattc ccgggttaat gccccatgtc accatagggg aaattttgtt 2314081 gccgtcaagg acgatagatt tatcgtaaac agcgcccggg tctgtgcgca gcgccttcca 2314141 ttcctctacg gccttgtcaa attcttcgcc ttttggcgtg tacttgcgat ttttgcaata 2314201 ttcaaacgtc acctcgtcag gtgcaatcaa acctgctctt gctcctgctt caattgacat 2314261 gttacaaaca gtcattcgtt catccatcgt catatttctg aatacttccc cagtgtattc 2314321 aatgacgtag cctgtgccga atttcacacc gtatttgccg atgacagcaa ggatgacatc 2314381 ctttgccgtt accccttttt gaagcgttcc atctacgcgc acttcaagtg tttttggacg 2314441 ctgctgccaa agtgtctgtg tggaaaggac atgttcaact tcactcgtcc cgattccaaa 2314501 tgcaagagcg ccgaaagcgc catgtgttga tgtatgactg tcaccgcaca caatcgtttt 2314561 ccctggaagc gttaagccta gttcaggtcc gacgacatgg acaatccctt gatccacact 2314621 gtgaagatcg gcaaggcgca cgccaaattc ctcacagttt ctttcaagcg ccgttacctg 2314681 gcgtttcgca acttcatcct ttatctcaaa acgattgaca gtcgggatgt tgtggtccat 2314741 tgtcgcaaat gtgttttggg gtcttctgac ctttcttccc ttttgtctca agccttcaaa 2314801 tgcctgagga gacgtcacct catgaatgag gtgcaaatca atatagagaa gatccggctt 2314861 tccctcacca tgttttacaa tatgctgatc ccaaatcttt tcgatgattg ttcgaggcat 2314921 catcttttat ttcctccctc tacctagagc taagaccgct taacgtaagc tgtcacacat 2314981 tagaaattgt attttcactc atgattgctg ccttaacttc ctctgtaatg gcctgagtgc 2315041 tgctgaactc ttcactccgt gccaagtctc ttgttctttt tccagaagcc aagactttgt 2315101 ttaccgcatc ttctacagct ttcgcttcct cttcaagccc gaaagatgtt ctcaaaagca 2315161 ttgccgctga caatatggct gcgaacggat ttgccatccc tttaccggca atatcaggcg 2315221 cggagccatg aacaggttca aacagatgaa ggccagagct tgataggctg gctgacggga 2315281 gcattccgag cgagcctgta agcatggacg cttcatcgct taaaatatca ccgaacatat 2315341 tttcagtcac cacgacatca aattgattcg gtgcataaat tagctgcatg gccgcgttat 2315401 ccacaagcat gtgctcaagc ttcacatcag gaaattcttg tgcaacgtcc tcagccactt 2315461 cacgccacag ccggcttgat tcaagaacat tcgctttatc tacagaggtc actttgcctt 2315521 ttctggctgc cgccattttg aagccctctc tgatcactcg ttcaatttcc gttcgcttat 2315581 aaaacagtgt atctactgct tcctgctcac cttcagtgtt tacataacgt ttgctcggct 2315641 ggccgaaata caagccgcct gtgagctcac gaacgataac gaaatcaaca ttatctatat 2315701 attctttttt caaaggcgaa gcgtcagaaa ggctttcaaa taccttcaca ggccgcaaat 2315761 tcgcaaacaa atcaagctgt tttctgatgc tgagcagccc tttttccggt ctcagttccg 2315821 aaggattttg atcccatttc ggtccgccga cagcaccaag caatatcgcg tctgcatttt 2315881 tacaagcagc aacggtttcc tccgggaggg ggttatgatg ttcatcaata gccgcccctc 2315941 caatcaggcc atattcaaat tcaaattcat ggttaaagcg ttcggcaaca cttttcagta 2316001 cgtctgtcgc tgattctaat acttcagggc cgatcccgtc tccgggcaat agagcaatac 2316061 gtttcttcaa gttaaccgtt ctcctttctt ttatgatccg acagctgtgt ggtttttcaa 2316121 tccgctcata ttcgactgga aaaccaattg acggtttact gcgttcaaat aggctttcgc 2316181 tgatgcttct aatacgtctt gcgctatgcc ccgccctgct gattcttttc cgttcaccaa 2316241 aactcttaca tacacctggg caaatgcatc ttcgcctttt ctattagact gaatgcggta 2316301 gtctaagagc tccacatcct tatcgatgca gcgctcaagc gtattgtaga ttgcttccac 2316361 gcttccagct ccagttgcag cttcctgaat aagctgtgcg ttttcttgat ttttcaaaga 2316421 tagagtagcc gtagggacct gacttgttcc gtaatgtact tgcagagaaa gaaattcata 2316481 cccaatcttg cgatctgtta ctttttcttc taaaataaga gaaacaagat cctcatcagt 2316541 gatttctttt ttcttctcag tcaactcttt gaacatcgta aagaatttat taatctcttc 2316601 actgtcaaat tggaatccta aagcagtcag ccggtcttta aatgcgtggc gtccggaatg 2316661 tttacctagg acaagcgcat ctgcggttac gccgacaagc tccggtgaaa taatttcata 2316721 agtcgatttt tcctttaaaa agccgtcctg atggatgcct gattcatgag caaatgcatt 2316781 atctccaaca accgctttgt tgcgcgggac agccatgcct gtcagtttgc ttactaaatc 2316841 acttgttctc ttaatctcgt tcagcgtaat acctgtttcg acttggtaga aatcttttct 2316901 ggtatggagg gctacggcaa tttcctctaa tgccgcgttt ccggctcttt caccgatccc 2316961 gttcacagcg cattcgattt gatcagcgcc attttcaatc gcagcaagag agtttgcgac 2317021 tgccattccc aaatcatcat gacagtgggc tgaaagcttt gctttgtgaa tgttcggaac 2317081 gttttctttc atatatttaa agatatttcc gtattccgcc ggggccaggt agccgacagt 2317141 gtccggaaga ttgataacac tggcgcctgc gtcaatcact ttctcgacga tttctgctag 2317201 aaacggcagt tcagtgcggc aggcatcttc agctgaccat tgcacaatcg gaaaacgttc 2317261 ttttgcgtat ttcaccattc caactgctct ttcaatgact tgttcacgtg tcattttcag 2317321 cttgtgcttc aaatgaatgt ccgatgtcgc gataaataca tgaattcttg gttgagcgcc 2317381 atcctttaac gcttcccaag cagcatcaat atcacctttt acacaacggg ccagaccagt 2317441 tactgaacaa tttttaatgg ttcttgcgat ttcctgaaca gctaaaaagt cacctcggga 2317501 cgaagcggga aatcccgctt caatgatgtc tgccccgagt ctttcgagct gcttagctat 2317561 ggcaagtttc tcctgtgtat tcaagttcac tccaggggac tgttcaccat cacgaagcgt 2317621 cgtatcgaaa aaattaattt tgcgcaacgg agaccaccgc ttccttcttc ttgccttgtt 2317681 tcacaaacgg catcatttca cgaagctttc ttcccactac ttcgatttga tgttcgttct 2317741 cgcttgcatt gatagcgttg aaacgaggac ggtttacttg gttttcgacg atccactctt 2317801 ttgcgaatgt accgttttgg atatctttta atacttcttt catagattct tttactttgg 2317861 cgtccacaac gcgagggcct gatacgaaat ctccccactg tgctgtgtca gagattgaat 2317921 atctcattcc tgcaagtcct tcttcgtaca taaggtctac gattaatttc agctcatgaa 2317981 gacactcgaa gtatgcaagt tcaggctgat aacctgcttc agttaaggtt tcaaatccgg 2318041 ctttgacaag cgcgcttaat ccgccgcaaa gaactgcttg ctcaccgaac aaatctgttt 2318101 ctgtttcttc tttaaatgtc gtttctaata cgcccgctct tgcgccgccg attcctttag 2318161 cataagcgag ggctttgtct cttgcttctc cagtcacatc ttgatagatt gcgaacaatg 2318221 caggtacgcc agctccttgc tcatatgttc ttcttaccaa gtgtcccggg cctttagggg 2318281 ccactaagaa tacatctaca tccgccggag gaacaatttg atggaaatgc acgttaaatc 2318341 catgagcgaa tactaatgat tttcctgctg tcaattcatc tttgatttca gcttcgtata 2318401 ctttttgctg ctgctcatcc ggaagcagaa ccatgatgat ttcggcttgg gctgccgctt 2318461 cttttactga aaatacttta tgtccgtctt cttgggcttg agtgaaagat tttccttgtc 2318521 taacaccgac gatcacgtct actccgcttt ctttaaggtt cagggcatgt gcgtggcctt 2318581 gcgaaccgta cccgataacc gctactgttt ttccagccaa tacgttctct ttgatatcac 2318641 cgttataata tacttttacc atttcaatct ctcccttgtt atgttttata caatagatat 2318701 tgttttattg gatgacgcct tttgctgggt tcccctcgca aaagccgttg tacctgttct 2318761 cgcgatttct ttaatgccat aaggttttaa taactcaata agcgcttcaa ttttgttaga 2318821 ttcacctgtc acctgaacaa cgatgctgtc tctgctgaca tcaacgacag aggctctaaa 2318881 cggttctatg attccattaa tctctgttct tgttgaaggt gcggagacaa ccttgattaa 2318941 ggccagctcc ctctggacaa tcgattgatt tgtgatgtct gtgactttca gcacatcaat 2319001 ctgtttgttg agctgtttcg ttaactgttc aacatcattt tcaccttcaa catgaacgac 2319061 gaaggtgatt ctggaaacgc cggctgtttc tgtgtgtcca actgtaatgc tttcaatgtt 2319121 gtaatgcctt tttgtgaata gaccggtgat ccggtttaac accccggagc ggttcaccac 2319181 agtcaatgtg ataattcttt tcaaggtttc acccccacca tttcatgcag ccctttcccc 2319241 ggagccacca tcgggaatac tttttcttcg ctggcaaccc gcacgtcaat gacaacaggt 2319301 tctcttgatg ttaatgcctc ttccagcttt tcctttgctt ccgcttctga tgaaattctg 2319361 atgcctttaa tgccgtatgc ttcggacaat ttgacgaagt caggctgaga agcgaattta 2319421 gattctgaat aacgttcttc atagaaaatt tcctgccact gtctgaccat tccgagacaa 2319481 gcgttattta aaatcactac cttgaccgga agatttaatt cgcgaataac atcgagttct 2319541 tgaagcgtca tttggaatcc gccgtctccg acaaccgcga caacagtagc atctttttcg 2319601 gccagctgtg cgccgatcgc cgccggaaga ccgaatccca tcgttccaag tccgcctgac 2319661 gtgacccatt tatctgcttt ttggaacgga taaaattgcg ctgaccacat ttgatgctgg 2319721 cctacatccg ttgcgacaat ggcctctcct tttgtaaatt gatgaatata ttcaatcaat 2319781 ttctgaggtt taaaaccttc ttcttcatta tctacatacc agagcggata ctcttctttc 2319841 cattctgcga gctgtttttt ccattcgctt gaatcgcttt gtttgccgtc ttgtttgatc 2319901 agctcctgca ggacaatttt gctgtctccg actacaggaa tctgtgtttt catgattttt 2319961 ccgatttcag ctggatcaat atcgatgtgg gctatctttg cgtttctggc aaagtgtttc 2320021 aggtttcctg tgacacggtc atcaaaacgg gcgccgatac tgattaatag atcacattca 2320081 tgaagggcca tattggctgt ataagtaccg tgcattcccg ccatccctag gaaaagcgga 2320141 tggtcagccg ggaagcctcc gagccccaaa agggtgtgtg ccacagggat ttgctgctgt 2320201 tcagcataat tttttaattc ttctgacgct tttccgtgca gtacgcccgc acccgccagg 2320261 atcaccggtt ttttcgcact gctcacggct tccacaagct tgcggatctg caaataattc 2320321 ggctctgttg tcggctggta tcccgggaga ttcatctcat gatcgtagct gaattctcct 2320381 tcaattgttg ctacatcttt cggaatatca atcaatacag gtccgggtct tccagttgtt 2320441 gcaatatgga acgcttcttt aatgatgcgc ggcagatctt ccggctggcg aacctggtag 2320501 ctgtgttttg ttactggcat cgtaatccct aaaatgtctg cttcctgaaa tgcatcgctc 2320561 ccgattacag aggttgctac ctgccctgta aagacgacta acggcaatga atcaatcatg 2320621 gcatcagcaa ggcctgtaac aaggtttgtc gctcccggcc ctgacgtggc aatgacgaca 2320681 cccggttttc cggagaccct tgcgtatccc tccgctgcat gaattgctcc ttgttcgtga 2320741 cggggaagga tatgtaccaa ccctgaattg tatagcttat cgtaaatcgg aagcacagcc 2320801 ccgcccggat aaccgaagat catttctact ttctcttttt ttaatgattc aatcagcatt 2320861 aatgctccgc tcatcgtctg tgtacattcg gcagatgctg aatccacctg tacattagtc 2320921 cccattttag ttcctccttt tggattttca tcctttaaag atcatctttt cattagctag 2320981 atagctgatt attcaataaa aaaagccctt ccgcccacaa tcagccgcgc agtaactgcg 2321041 atagctaaaa ggggcgaaaa ggcttttctt tccgcggtac cacccttgtt tacggcctgt 2321101 taatcggccg tctcatggat atttctatcc gctttagtaa cgagtgaatc aagttcaccc 2321161 ggccaagtcc tactgtcatt tcagactggc actctgaggc gagttcacct tgtaaagctt 2321221 cgccggttct cagctaaccc ggttctctgt ggaaaacttt atcaaggcta cttatcctca 2321281 tctgcgcttt tcatattcag ccttcggaac ggctttccag ctgttcaaga aggtcgtttg 2321341 tttttcattt ttttagaatc atactgcgat gattttcgct tgtgaagctt gcatttatct 2321401 tttgttgaac tcatattacg ccgctttgga cgcagtgtca acagcatttt ttaaaattat 2321461 tagacaattt tgattaatca atctatattg tatacgcttt cattattggt acaaaaggaa 2321521 ttgcaaatgt taaaagtttt tataattttt ttattaatct atcaagaata caccagaatt 2321581 atttaatttt atataaacat ggaagatttt ataacacgat atggttcgta tatggattga 2321641 gtctgacaga tcatcttgca atccatttca atttcggata ggcacttctc ttgttccctc 2321701 ggcatacatt aatgatatct tgcaaagaaa aggtgatacg atgaataaat catttgcaga 2321761 catgcaagga tttcctgcgg gctttccaag cttccccaac tttccgcagc agtactatcc 2321821 tgctgtccct cccttttacc agcaaagcca gcagccattt ggaggctacg gatacggaca 2321881 gccgttcagt caggcataca gcccgttaac cactccctct ggaatgtact cctcattccc 2321941 atacgcttca ggattttacg gacagcaatt ttcaggtgca ggctttagcg gccatggcgg 2322001 cagcttaagt gctccagcga tacatgccgg cggattcagc ggggcgccag gcgtacacgg 2322061 aggctttaga tattaaagaa taccacaagg gccgaacatc tattgcggtc cttttattgt 2322121 tttaaaacga cttcacaagt acagtcacat tttctgtctt tatatttgga aacaggatgg 2322181 aatatgatta agatgaattg aacgatattc tgcacaatcc gtaagttttc gaggaggaat 2322241 aaaattgcat ataaaaatag acgatttaac tggacgtcag gtggtttcac tggtgaatga 2322301 gcatttacat agcatgacgc ttatgtcccc gccagaaagc attcatgcct taggtctaga 2322361 aaaactaaga gggcctgaaa taacattttg gagcgcatgg gaaggtgatg aactagctgg 2322421 ctgcggagcg ctaaaagaac tggacacccg gcatggagaa atcaaatcaa tgcgaacatc 2322481 tgcatcacat ttaagaaaag gcgttgccaa acaagttctc cagcacatca ttgaagaagc 2322541 cgagaagcga ggctatgagc ggttaagctt agaaacgggt tcaatggctt catttgagcc 2322601 ggcaagaaaa ttgtatgaaa gcttcggttt ccagtattgt gaaccgtttg cagactacgg 2322661 tgaagatcca aacagtgtgt ttatgacgaa gaaattgtga gacggcttta taaggataga 2322721 taagtgcagg ggaaggtctg tcttatctat ctttttttat attcacacat ttttcacctt 2322781 tatgatacac gccaatgttt tcaattttgt ttaattcaaa gaacagcggg aattacaaac 2322841 gacatgaacg atatcatgca aattcataaa ggaggagatt gatatgaaaa gcatagttgg 2322901 tgtatatgaa actccgcagg aaaccatcgc agcgattgaa ggcttactta caaaaggcta 2322961 tgattctgat gacatttctg ttgtgacaag ccggcgagat acagattatt tggagtcacg 2323021 tacaggaaca gaagtcaatc aagctatcga tgcacatcag gacgaatctg aatctttttt 2323081 cgataaactg aaagattatt tcacaatgga tgatactgct acacacagca aagcattatc 2323141 cgacttggat attaaaactg atgaaataga caagtatcaa gaagatttgg atgacggaaa 2323201 acttctggta gccgtcgata cagatgcaga tgtaattgct cctattgata acggcaatgc 2323261 cctttcaggc ggcttttcaa gcacaaatga attggattat acaacgaaag aagaaaaaac 2323321 gatgccgctc cgggaagaac agctgaaggt cgataaggaa gacgttcaaa ccggcgaagt 2323381 agaaatagga aaagaagtga aaacagaaaa aagagatatg gacattccgg tgagacatga 2323441 tgaaatttat gtcgaacgcc gtccagtgga tgaaaataaa acggacgctg ctcccgtcaa 2323501 cgattcggaa gagatcagag ttccaatcgt tgaggaaaag ctggaagtga ctaaaaaacc 2323561 ggttgtcact gatgaagtgg ttgtcggcaa acgcactgtt gaagaaaatg aacatatttc 2323621 tgaaactgtg aaaaaagaag aacctcgtct gaataaagaa ggaaaagttg acggcttgga 2323681 tgatgatccg ttaaataaca aatgaaaatc atagaccgac aacaaaaaac ctcaaatcct 2323741 aaatggattt gaggtttttc ttttggtacg tcccaggaga gattcgaact cccgaccgac 2323801 ggcttagaag gccgttgctc tatccagctg agctactggg acacgttttg tttttttgtt 2323861 tttcgcttta actatcagcg acaagattta ttatatatgg gatgcaataa taagtcaacg 2323921 gttttttaga atttttttca tgaggaagaa aattttcttc ctcatgacat tttcatagtg 2323981 tgactcgatt ttgcagatcc tcaatttcat tgcctgcttg gtcgtaaaaa cggactgtcg 2324041 cagcatcatt ttctaatgtc agtatagcat agctttctgt cctgcgcacc ctcggaagcc 2324101 ggatgctgcc tgggttaatc atcagttttc cgcgcagcac ttcgcttccc gcgatgtgcg 2324161 aatgcccgaa gcagataaca tccgccccga gctcctctgc acgatagtat acgtttaaca 2324221 aggtctgttt tataccgtga aggtggccgt gtgtgactag tatttttctt gagccggcag 2324281 tcagaagaag ctcgtcctta aaatcgccgg caaaatcgca attgcctttt acaaccgcat 2324341 aaggctccaa tgcaggatgc ctcgtctcaa gctcagagtc cccgcaatga atcatgagat 2324401 caacttctgc ctcatgccgt ttcgcaatgg tttggagttc ttcttcaagc ccatggctgt 2324461 cactgataat cagcacgttc atgtacaagc ttcctcctta tgcctccaaa agcttagaca 2324521 gctttttaag cgcgtcagcc ctatggctga ttttattttt ttcatcactt gtcagttcag 2324581 ccatcgtctt atctttatct ttcacgataa aaattgggtc atagccaaag ccatattctc 2324641 ctctcggttc ttcagcaata tacccttcaa catggccttc gactgttttt gtttcctctc 2324701 cgggaatact cacggccagt gcgcagcgga aacgggcggt gcgctgttct ttttcgatac 2324761 ctttcagctc gctgagcact ttttcgatat ttgcctggtc gtctttctgt tcccctgcat 2324821 agcgggctga ataaaccccg ggtctgccgc caagattatc gatggatagt ccggagtcat 2324881 ccgcaatcac cattttgttc actgctttgg caacagcttc cgctttcata atggcatttt 2324941 cttcaaatgt atggcctgtt tcttcaattt cctctgtgaa tccaatttca gctaaagatt 2325001 tgacatcata gcctcttggc tcaagaattt ctttgaattc cttcactttt cccggattat 2325061 gtgttgcaat aattgcttct ttcatgatga tcaagccttt ctgtctttat ttcagttctg 2325121 gcagagaatc acccagcact tctttttgct tgtcaatcag ctcttggatt cctttttccg 2325181 caagacccag aagaccgttc agatcctctc tagaaaaagt tgcctcttcc ccggttccct 2325241 gcaattccac aaaacggccg ctgcctgtca tgatgacatt catgtcaact tcagcagagg 2325301 aatcttcttc ataatttaaa tctaacaaaa ttccctgttc cttatcaatt ccaacagaga 2325361 ttgcagcaag aaaatcagtg atcggatttg tcttgattgt tcctgctttg atcagcttgc 2325421 caatcgcaat cgccatagca agaaatgcgc ctgtaatgga agctgttcta gttcctccat 2325481 cagcttgaat gacatcacag tcaatccaaa tcgtccgttc accgagcttt tccagatcta 2325541 caacagctcg aagcgcgcgg ccgatcaggc gttggatctc cattgttctg ccggaaattt 2325601 tccccttaga agattctctg attgttcttt ggtttgttgc ccgcggcagc atgctgtact 2325661 ctgctgtaat ccagcctttc cctccgcccc gcaaaaacgg cggtacgcgg tcctcaacag 2325721 acgcgttgca gattaccttt gtatttcccg ctgttattag aacagaacct tccggatggc 2325781 tgataaaatc caaatcgaat gtgattggac gcagctcatc gtgttgtctt ccgtcatgtc 2325841 tcatgtttta cctccgattg tatgtacata aaccattttt gtcccggaat tgaataaaga 2325901 aagaggcagc cggaacgcta acctctttct tcctagtata tcaaaaatcc caatttaaaa 2325961 actacccgta ttcacttgag atggtctgga gaccggttct gtgagctttt cgcctttttc 2326021 atttaccagc tctgattttc cgttcacttt aacagagacg ctttttacat ccggctgctc 2326081 cgttaacgtc agcacaatgc tgttcagcac ttctgaagaa atcattttcg tcttctcatc 2326141 ggcgctgccg aatatagatt gattgaaatc caacgtcacg cgcccgtctt tgattttcgg 2326201 tttgctgacc agctttacat cttcactgaa gtctgttaac agcccgctca ccttgctcgg 2326261 ccctttagcc aattcattaa tggctgctgt gatgtcgtct ttttccgaat tgtcgattcg 2326321 tttggtcacc ggcacgtagt attcactgtc ttcattttcc gccaaatagt agactgtcag 2326381 cggatgggta gcagtgagat catttacacc ggctgtttcc aaattaatgc cgtctttgcg 2326441 gcttaaatca tctgagatcg gcgtccctcc tacaggcatc tccttcagtt catgcccgtt 2326501 tattctcagc ttcactttat ctatcgaact aaattgcgtc agcgtccacg tcacagattg 2326561 aacgattttc tgttcgtctt ctttcttata atttttgaac tcattagaga aatcagctat 2326621 cgccgttcca tcttttttga tgtcaacgtt aacggtggtg tcagccggca atacagctct 2326681 gaagccattc ggaagaattt cagacacagg cccgccctgt acgaggtatt caagcgcctg 2326741 cttagccgtg ctctcacttt taggaagagg cagcgtttgc gcaacaacat acccgttttt 2326801 atcaatgaga taaagctccc tcataacagt agatgaggct tgatccgctt ttgcggtatc 2326861 gcttttttca ctttctgttt ttttggctgc tgttgtattt gaattggcac ccgcttcatc 2326921 gttcacgaat gtaacgtctt gaggcggatc aatttcctcg gctgccttat cagattgaaa 2326981 caaaccgcat ccggataaaa gcaaggcaga ggtgagacaa gtggcaccaa tgactgcagg 2327041 tccttttttc agcatacttt tccctcctaa ggatgtttgt actattatgt atacgagcct 2327101 ctttaggaaa tagaccgaag aattccggca aaacagaaaa aaacccgcaa cataccgttg 2327161 cggggaaaac tatcttttaa tcggttcttg cagtgagata cattccacat gcccgacttc 2327221 atggccaaac caatcgtctg cgatttttgc aaactgatca cgcgcccctg ttgtcaggaa 2327281 ctgatgatcc ggggcaatcg gagactggtt cagcagccct ttataagaga gaattgtgct 2327341 gacttcccgg gctgtttcat cgccggacga aataatgttt acgtgctctc ccatatatct 2327401 ttgaatggct tcttttaaaa tagggtaatg ggtgcagcct aaaatcagcg aatcaattga 2327461 tgtgtctttt aacggataca gcgaggtttt aacaatctcg tctgctgttt tgtcgagaaa 2327521 cttcccgctt tccacaaaag gcacaagcag cgggcaggca aggttttcaa ccttcaaatc 2327581 agggtttaat gccaaaagcg cttcttcgta tgcattgctc ttaatcgtat tctctgtgcc 2327641 gatgacaccg atatgctgat tatccgtcac ttttatcgct gctctcgcac caggctggat 2327701 gactccgacc accggtatac cgacgctgcg ctggatgtca tccaaagcga tcgctgttgc 2327761 tgtattacag gcgatcacga gcattttgat gtggtggttt tcgagtaaat aattcgtcag 2327821 ctcccacgta tattgaagca cctcttcttc agggcgcggc ccgtaaggac accgtttcgt 2327881 atccccgacg tagataatat tttctttagg tagctgtctc atgatttcct tcgcaacggt 2327941 taaaccgcca accccggaat caatgactcc tattggttgt tccaacaaaa tcgcctcatt 2328001 ttctcttcat ttcatgctgc agtttcatca aagatttttc gaagatggct atttcttcat 2328061 ctgtaaacga ttcgaacata tcacgcagat attcctgtct ttttgtaatg acctcttgga 2328121 taatccgttc tccttcaggc agcagatgta tcctgacaac acgtctgtcc gccgggtcct 2328181 tgacccgctc aacaagctca tttttttgca tgcggtcgat taagtccgtt gtcgtgctgc 2328241 atgccagata cattttgccc gataattcac cgattgtcat atctcctaat tcataaagcc 2328301 attgcaagcc gacaaattgc ggcggcgtaa tcgcatattg gttaaggatt tctcgtcctt 2328361 tttgcttaat gatcgcggca atgtggcgga gtgacttttc aatatccgca acatgctcca 2328421 aaggttttga tgtcatttgt ccatccctca ctcaaggatc tcttacgcac aaaagcgttc 2328481 cgtgtctatt ttccttcttt tttgaagaaa atgcaagact cgcaggagag aaatagagga 2328541 ctttagtcaa acaacatcaa gaaataaaat ttaatttatg acttgcctac gttttgcaca 2328601 gcattccaaa tatggtttcg aatgttccaa acaaacagca ataaccggct ccttccaaaa 2328661 gaaggaatac cggcaaggat taaagctcta gctcacccat tctaagaagc tcaacaacgg 2328721 cttgcgaacg ccctttcaca cccaatttct gcatggcatt tgaaatatgg tttcgaacgg 2328781 ttttctcact gataaatagc tcgcttgcaa tctcctttgt tgtcttatct tgaacgagca 2328841 attcgaacac ttctctttct cttttcgtta gcagcggctt cgattgaaat tctttctcct 2328901 tcaagtattg taaccctcct tgctaaggtg agagcgaatc agaaacgaat gggttttgat 2328961 atagtcgaga tatcatatgt aagaagggcg caggaggtga cgtttacaag ataattagtt 2329021 tatcgtgtat gaagaagcgt ttctttctcc tcatccgtcc agctgacagc cttgccgctt 2329081 tcctttgaga cttgaaccat cacgactgcc ccggtgaagc agggttcgcc ttcgaggttc 2329141 tctccgagat agtgcaaggt aagagatgaa ctgccgactg cgcttgtttt cacatagatg 2329201 cgcaactctt cataaggcat gacttggcgc aaataatcgc attgctggct tgccacgact 2329261 gtcatggtct gtttgttttc actcatcata ttcagctttt taaaataaga aatccgcacc 2329321 tcctcaaaat atataaaagg ggttacatta ttcatatgcc caaacatgtc tgtctcggaa 2329381 aatcttacgg ataccttatt gaaaaaagaa aaggatgttt tccattcttg aaacggcata 2329441 tcaatataag cgggaagctt catctttttt catctcctta ttgtttaaaa aaacctctcc 2329501 catgcggaag aggttttttc ttcttatact ctgtcgcttc cgaagaaatt gcggaacgct 2329561 tgtaagtttg tatctctatt caaggctgca atcgaagtgg taagcggaat ccccttcgga 2329621 caggattgaa cacagttttg cgagttgccg caatctgcaa ggccgccttc atccattaat 2329681 gcttctaatc gttcagattt attcatggcg cctgtcggat gcgcgttaaa caggcggact 2329741 tgcgacatcg gtgcaggccc catgaacttc gatttgctgt tcacattcgg gcaagcttcg 2329801 aggcagacgc cgcatgtcat gcattttgat aattcatatg cccattgacg acgtttttcc 2329861 ggcattctcg gccccggtcc taaatcgtac gtaccgtcaa tcggtatcca cgcttttact 2329921 tttttcaatg aatcaaacat tctgctgcga tcaacctgca aatcacgaac gactgggaat 2329981 gttttcattg gttttaaacg gattggctgt tcaagctggt caataagcgc cgtacaagac 2330041 tggcggggtt ttccgtttat aaccattgaa catgcgccgc atacttcctc aagacagttc 2330101 atatcccatg tgacaggggt tgtcttctca cctttgacat taaccggatt ccggcggatt 2330161 tccatcagag cggaaatgac gttcagattc gggcggtatg gaatctcaaa ttcttcatca 2330221 taaggcgtgc tgtcagctgt atcttgacgt gtgataataa atcgtatggt tttttgttca 2330281 ctcatgatta tttcgccacc ttcttcttcg agtaatcccg tttccgaggc gttatcagtg 2330341 atacatcgac atcctgatac tcaaattccg gcgcttcata cgggcttaca tgtttagcca 2330401 ttgttgtttt gagccattca tcatcattac gttcaggata atccggttta taatgggcgc 2330461 cccggctttc attacggttg tatgcgccaa gggtaatcac cctcgcaagc tgaagcatgt 2330521 tcgagaactg gcgtgtgaac atcgctccct ggttgctcca ttttgtcgtg tcattgatgt 2330581 tgatcttttt gaagcgctcc attaactcct gaattttgtc atccgttttc aaaagcttgt 2330641 cattatggcg gacaaccgtt acgttcgccg tcatccactc accgagctct ttgtgaagaa 2330701 cataggcatt ttcggttccg tccatactca taatatcagc ccatttttct tcttctttct 2330761 taacgtgagc gtcgaataaa gatgaagaca tgtcttccgc tgaagattct aagccgttta 2330821 catatttcac cgcattcgga ccggccacca tgcctccgta aatcgcagac agcagggagt 2330881 tcgctcccaa gcggttgccg ccgtgcatag aataatcaca ttccccagcc gcaaacagtc 2330941 cagggatatt tgtcatttga tcgtaatcca cccataaacc gcccatagaa taatggaccg 2331001 ccgggaagat tttcattgga agcttacgcg ggtcgtctcc catgaatttc tcataaatct 2331061 caatgatgcc gccaagctta atatcaagct ctttcggatc tttatgagac agatcgagat 2331121 ataccatgtt ttcaccgtta ataccgagct tctggttcac acacacatca aatatttcgc 2331181 gtgtcgcaat atcacgcggc accaggtttc cgtatgccgg atatttttcc tccaggaaat 2331241 accatggttt gccgtcttta tatgtccaca cgcgcccgcc ttcaccacgc gctgattcac 2331301 tcatcagtct tagtttgtca tcgcccggta tggctgtcgg gtggatttga atgaattctc 2331361 cgtttgcata atacgctccc tgctgataaa cgattgacgc agcagatcct gtattaatca 2331421 tggagttcgt tgattttcca aagatgattc ccggtccgcc cgtcgccata atgacagcgt 2331481 ctgaacggaa ggattcaatt tgcatgtttg tcaggttttg tgcaacaatt ccgcggcagg 2331541 ttctgtcatc atctaaaaca gcgccaagga attcccagcc ttcgtatttt gtgaccagac 2331601 ccgcaacttc gtatctgcgc acttgctcgt ccagtgcgta aagcagctgc tgtcccgtcg 2331661 tcgcaccagc ataagcagtt ctgtggtgct gtgtaccccc gaatcggcgg aaatcaagca 2331721 ggccttcagg cgtccggtta aacatgacgc ccatccggtc taataagtgg atgatcgaag 2331781 gcgccgcttc acacatcgcc ttgaccggcg gctggttggc aagaaagtct cccccgtata 2331841 ccgtgtcatc aaaatgttcc cacggagagt caccttcccc ttttgtattg accgctccgt 2331901 ttatgccgcc ttgcgcacaa actgaatgag aacgtttgac aggaacgatg gaaaacaatt 2331961 taaccgccat tcctgattcc gctgctttaa ttgtcgccat gaggccggca agacccccgc 2332021 cgactacgat aatgcttgat tgactcatga tagcccctct ccctctagta atctagtact 2332081 cttaaacaaa tgcaaaaatc gcttttaagc ctacgtatga cagtgcaaca aaaataatca 2332141 gcgtaacgta tgtcgaaatt ctttgagaac gaggcgttac cgtgatgccc catgtaacag 2332201 cgaaagacca taaaccgttc gagaagtgga aaattgttga taaaacaccg acaatgtaaa 2332261 aaccaagcat agccggagag ctcaaaatat tcgccatcat gtcgaaattg acctcagcac 2332321 ccatttgtgc ggcaatgcgg gtttcccaca cgtgccagct gacgaaaatg agggtgatga 2332381 taccggttac acgctgcagg acgaatagcc agtttctcat gtagctgtat tgaccggcgt 2332441 tatttttcgc agtaaacgct atgtacacac cataaactgc atgataaatt aatggtaaga 2332501 agataataaa aatttccaag gcatacctga aaggcaggct atccataaaa tgagcagcgc 2332561 tattgaatgc ttcagcgccc cttgcggcaa actggttgac gactaaatgc tgaataagaa 2332621 agatgccgac cggtatgacg ccaagcaagg aatgcaatct tcgaaaataa aactctctgt 2332681 tcccagacat tactttaccc cctgtttgat aagtgcgaaa tgtgctaaat ctcttccccc 2332741 acttctttca attgtaagca ctttattaag atttattgac aatttcattt tactcctccc 2332801 tcaaaagggc gtcaagaaaa cgcgtacata aattataatt ttccgaattg attagttgat 2332861 tgaaaaattt tattttatca atatatattt cttgcttaat ttttcataag aattacagga 2332921 tcattctgta atcctccccc ctgtttgagc tataatatac gcaggagaga ggggagacag 2332981 atatgaagtc taaatttgaa gcatctattg acaacctaaa agaaattgaa atgaacgctt 2333041 atgcctacga actaatacga gagatcgttc tcccagatat gcttggccaa gattactctt 2333101 ccatgatgta ttgggcagga aaacatctcg cccgtaagtt tcctcttgaa tcatgggagg 2333161 aatttccggc cttctttgaa gaagcgggct ggggaaccct caccaacgta agcgctaaaa 2333221 aacaggagct tgaatttgaa cttgaagggc cgatcatttc caaccggctt aagcatcaga 2333281 aagaaccttg ctttcagctg gaggctggtt ttatcgctga acaaattcaa ttgatgaatg 2333341 atcagattgc cgaatcatat gaacaagtga aaaagagagc cgataaagtg gttctgactg 2333401 tgaaatggga tatgaaagac ccagtgtaat caaaaaggcg gtgactgcat agtcccgcct 2333461 ttttgattgt cattacacag ctgaagggtg ttttgaaagc tcaaatgcat cgtgaagcga 2333521 ctcgactgct ttcaccatgt cattttcgct tacgactgtt gacactttga tttcagatgt 2333581 gctgaccatt ttgattaaaa tgtttttttg cgccagtaca gcaaacattt cagccgctac 2333641 accgggattt gagaccatgc cggatccaac aatagatact ttagccaatt tgctttctgt 2333701 ctcgattttc tcaaattcca gcgcgtcttt atactcttca agcaccgcaa cggtttggtc 2333761 tgcatcttct gttttgacag agaaggaaat tccagtcttg tcctcggcct gcgtttggat 2333821 aatgatatcc acgtttatgt ttcttttggc aagtgttgta aaaatagtag acaaagttgt 2333881 caggccgcta gtcagcccgt aaatggttac tcttgtgatt tgatcttcaa atgcaatgcc 2333941 tctgacaatt aaattctgtt ccatggatga ttcctcctca attaatgttc ccgcttcggt 2334001 ttctgtactt gaacgcactt ctaacggcac ttggtaattt ttcgcgaact caactgctct 2334061 cggatgaaga acaccggcgc ctaaattggc aagctcaagc atttcatcgt atgagatgcc 2334121 ctcaagtttt ctcgctgatt tcacatagcg cggatcggtt gtaaacacgc ctggcacgtc 2334181 tgtgtatatg tcacatttat cagcttttaa agcggcagcc aaagcaactg ctgttgtatc 2334241 tgaaccgccc cggcccaatg tcgtaatttc acaatcctct gtcatgcctt ggaatcctgc 2334301 aacaatgaca atttttcctt tttcaagctg gtctgctaaa accgaagtgt cgatatctgt 2334361 aattctggcg tttccgtgaa tggcctccgt acggattccc gcctgccagc cagtataaga 2334421 cacagcgtca tagccttttt cctgcaatgc cattgaaagg agtgaaatcg tgacctgctc 2334481 gcctgtcgcc agcagcatat ccatttcgcg tttgctcggc tggtcagaaa tagcttttgc 2334541 aaggctgacc aattcgtcag tggattttcc cattgctgaa acgacgacaa cgacttgatg 2334601 gcctttctgt ttttctgcaa ttgcgcggtt tgccgcattt tgaatttttt cgactgagcc 2334661 gacggaagtg cctccgaatt tttgtacaat aagacccatg tattaccacc ctttacattt 2334721 tggttcgtgc gggtgaggag aaagagcgct ttgtccacaa taaaaaaagc aatgagagga 2334781 atactctcat tgcttatcaa ttaatcatca taaatgatta tgaacaacga gatagccctc 2334841 caagaaaatg atttcttgac agccttacat ttattcaatg cacggccagc aaataatacc 2334901 gatggggttt tatttgcttc ggcgacgctc ccctttcagc ctttttcaca gaatccatct 2334961 ttctccaaag gcatactctt gaagttcgca cctctatctt caccatataa cacgatctaa 2335021 ctatgaaatt agttcacatt ttatcagatc ttatttaaaa ggacaacatt atttttgcaa 2335081 tttgtcgtaa aggagctgag ccgccgctgc gggaacaccg gcttttttga tgtcctcaag 2335141 gcttgcttcc ttcatttttt taacggaacc gaaatgcttt aacagcattt tctttctttt 2335201 ctctccgata cccgggatgt cgtccaaaac ggattgaaac gcgctttttc cccggatttg 2335261 cctgtgaaaa ctgattgcaa aacggtgcac ctcgtcctga atgcgctgca ggaggtaaaa 2335321 ttcctggctg tttcgttcca gatacgccac ctccagcgga tcaccgatca gtaaatttga 2335381 ggttctgtgt ttttcatctt tcgctaaacc ggcgatcggg atatccaagc cgagttcatt 2335441 ttcaatgaca tcccttgctg cgttgatctg cccttttcct ccgtcaatga taatcagatc 2335501 gggcagcggc agattctcac gaagcactct cgtatagcgt cttctgacaa cctctctcat 2335561 agaaccgtaa tcatccggcc ctgtaacagt tttgatttta tatttgcggt attccttttt 2335621 gtatggtttg ccatcgataa acacaatcat cgcggaaacc gggtttgtcc cctgtatatt 2335681 tgagttatca aacgcttcaa ttctgtgcgg cgtataaata tttaatgcct cacctagttt 2335741 ctgcactgcc ccgattgaac gctcctcgtc ccgttcgatt aaagagaatt tttctttcaa 2335801 tgcgattttc gcatttttat gggcaagcat gagcagttct tttttcgggc cttttttcgg 2335861 ctggtgaacg tttgtttcca gtagctgctc gatcatagat tgatctatgc tgtccggaac 2335921 taaaatctcc ttcggaagga agtggttgtt ttttgaatag aactgcccga tgaacgtgag 2335981 gaactcttca tctgcttcct gataaagcgg gaacatgctg acatcgcgtt caatgagctt 2336041 tccttggcgg atgaaaaaga cctgcacgca catccagccc ttatcgtacg cgtacgcgaa 2336101 cacatcacgg tcgactagat cgttcatcgt cattttttgt ttttccatcg ttgattcaat 2336161 atgggcaatt tggtcacgaa gctcttttgc tcgttcaaac tcaagattct cagcagcttc 2336221 atgcattttc tcttcaagct cttttttgac ctcattatag ccgcccctta agaaacgtgt 2336281 aatgctttca accagctctc tgttcgtctc ttcggaaata tcctttacac acggagcaag 2336341 gcattggccc agatgatagt aaaggcacac tctgtccggg agcttggagc attttctgag 2336401 aggatacaga cggtcgagca gtttttttgt ttcccttgct gcctgtacat tcggatacgg 2336461 cccgaaatag cgccctttgt cttttttgac attgcgggtg acaatcagcc ttgggtggcg 2336521 ttcatgggtg agttttatga aaggataggt tttgtcgtct ttgagcatga cgttgtattt 2336581 cggatcatgc tttttgatca gattcatttc taaaataagc gcttcaagat tggaggacgt 2336641 cacaatatat tcaaaatcct cgatttccgt cacaagcctt tgggttttcg cgtcgtgaga 2336701 accggtgaag taggagcgca ctctgttttt cagcactttt gctttcccta cgtagatcac 2336761 agtctgctgc cggtccttca tgagataaca acccggttga tcaggaagga gggcgagttt 2336821 ttctttcagt tgtttgttca tatgttaccc ttccttatgt ttaatccttt atttccagtt 2336881 taacacgaac gtttgttttt ctctatggtt cacaattggc gaataaaaaa agcgatccct 2336941 caatcggaat cgctctggca tgtaagcagc ggaaaattaa agatgtttgt ttacaagctc 2337001 ttgaagcgct tcttttggtt tgaagccgac tgaagtttca actacttcgc cgtcttttaa 2337061 cacaagaaga gtcgggatgc tcataacgcc gtattttccg gcagtttctt ggttttcgtc 2337121 tacatcgatt tttacgattt tcagtttgtc tcccatttct tgatccaatt cttcaagaac 2337181 aggtgcaatc attttacaag gtccgcacca aggagcccag aagtctgcca gtacgacgcc 2337241 ttcgcttgtt tcagctgaga aagattgatc agttgctttt acgatagcca ttattgaatt 2337301 cctccaatgt gaaatgatga tttttagtat agcatctccc attcgttcac gctattttaa 2337361 tgcttacaaa ttattttttc ctgatcacag ccggtttact catttttata tggttgaatg 2337421 ggatatgctc tttttttaaa acacaaatct gataatggcc ccgatcacta caattgcccc 2337481 aataatcatt aaaatggtac gaagcataag atcacatctc ctcttcactg tcatgtactt 2337541 taccatgccc tgccggagct gttttaaaac ctgaaaaaga gcgccggcat gaagctccgg 2337601 cgctcttgcg cgattaagaa tcagcacgca gcgtaagtaa gacgactgac attggcggga 2337661 gttttacttt cagtttgttt ttgctgagcg tgtattgtct gaaggattcc ggtttgacat 2337721 gatgaggatc gtcaaacgtg ttatgcgcat tcattttttc tgccgtaaga atgactccgg 2337781 aatggtccgc tgccttgtgt aggcccctca gctcgatttc cgcctctgct ttgttttggt 2337841 gatcgatgtt gcaaattgtg atattgatat cgccttcagc ttgtttcgac gctgaaatgc 2337901 tgatttgcgg aagcgtttca ccgttccatt catagtcggc agacattgtc tctgtggcta 2337961 aaagagaagc gtcctggtgc accttaaaca tattgaatac atggtacgtc ggtgtcaaaa 2338021 gcatccgctc tccctcagtc aaaatcatcg cttgaagaac atttactgtt tgggcgatgt 2338081 tggccatttg cacccggcgg caatgctgat ggaaaatgtg gaaatgagaa gccgccacca 2338141 gtgcatcacg aatggtgttt tgctgatata agaaaccggg attcgtgcct ggctcgggat 2338201 caaaccacgt gccccattca tcaataatca gcccgacccg ctgctccgga tcgtaccggt 2338261 ccataatcgt gccgtgtttt tgaatcaatt catcgatgta tttggctttt ttcatcgtaa 2338321 taaaccattc atcttccgtg aattctgtgg ctgatccttt gcccttccag aaatcccccg 2338381 gaatcgtgta ataatgaaga ctcaacccgt ccatcaggcc agcggctttt ttcataagca 2338441 cgtccgtcca attaaaatca tccacatttg cgccgcctgc aattttataa atgtcattcc 2338501 cgctgtaatt gcggacataa gtctgaaaac gccggtacag atctgcgtag tattcgggat 2338561 gcatgttgcc gccgcagccc cagttttcat tgcccacgcc gaaatatttc agcttccaag 2338621 gctcttctct tccattttgc tttctccagt ctgacatcgg cgtgccttct tcaaatgtca 2338681 tatactcaat ccactccgac atttcctgaa cggttccgct tccgacattg ccgcaaatat 2338741 atggctcgca ttcaagcagc tcgcaaagca tcataaattc atgcgttccg aattcatttg 2338801 attcaattgt accgccccag tgagtgttca gcattgtctt acggtcaccg acaccgtttg 2338861 cccaatggta ttcgtccgca aaacacccgc ccggccacct aaggacagga atgtgcagct 2338921 gtttgagcgc ctccagcacg tcctttcgta tcccgttgat attggggatg tctgagtccg 2338981 ttccgaccca gatcccctca taaatccctc ttcctaaatg ctcagcaaaa tgaccgtata 2339041 tatttttgtt aatggttcct tttgcgatat ctgtttgaat cactgcttga tgttcagaca 2339101 tgcctctgat cattcctttc atacggatat gaaaagcacc acagtcaaat atgtgatctg 2339161 tcgtttgcct gaggagtcag catgaatgta agcgctttta aagtaaccat attatatatg 2339221 ttcgtacatg tcaacgacat tttctattgt ttttatattt gtacgtatgt atttataaat 2339281 atgaaaaaac ccggactttt aaagtccggg atttccttta tgagtgtata ttcagctgtt 2339341 tgaattcctc agttaataac gggacaactt caaataaatc accgacgatg ccgtaatccg 2339401 ctattttaaa gatatcggct tcggggtctt tattgatggc gacgatcacc ttgctgtttg 2339461 acatgccggc caaatgctgg atggcgccgg aaatgccgca tgcaatgtac aaatccggag 2339521 taacgacttt cccggtctgc ccgatttgga gagcataatc gcaataatca gcgtcacatg 2339581 ccccgcgaga agccccgact gcggccccta gcacctctgc aagctcctgc agcggctgaa 2339641 atccttcctt gcttttgact cctcggccgc ccgcaacgat aattttcgct tcggagagat 2339701 caacaccgtc cgccgttttt ttcacgacct cttggataac agtgcggagg tcagtaagag 2339761 aaacatcaat gctttcgatg ctccccgatc tgctggtgtc tttttctgaa gcttgaatgt 2339821 tattggggcg aattgttgca aagatcatcg gatcggttga aatgacgcgt tcaaaagctt 2339881 tccccgagta aatcggccgt gtgaacacaa cattccctcc ggtaacgctt acatctatag 2339941 catcagaaat taagcctgtt tgcagacggg cagcaagctt cggtgaaaga tccttgccca 2340001 ttgccgtatg cccgaagatg actgaatcag gattttcttg ctcgataaca cctctcatga 2340061 cctggctgta cccgtctgcc gtgtatgttt tcagcttcgg gtcctcagcg gtaagaactt 2340121 tatctgctcc gtaatgaata agctcttgtg caatgctttg tacattttca ccgatgagaa 2340181 caccgatgac ttccccatct cctgaaatgg ttcttcctgc agctattgct tcaaaggtga 2340241 catttcgcaa ttccccatcg cgtatttctc caagcacgat cacttttttt cccattctaa 2340301 catccccctg tttctttgaa tgtccaagtt ttaaatgact ttagcttcgc tgcggagcaa 2340361 tgaaacaagc tcttttgcct gttcagcagg ctcaccttgg agaagcttcc cggcttcttt 2340421 tttcggcggc agaaaacgtt caatggtttt cagctttggt tcagcatcct cttcgtccag 2340481 atcaagatca tcaagttcaa gctcttcaag cggctttttc ttagccttca taattcccgg 2340541 aagcgatgga tagcgcggct cgtttaagcc ctgctgagct gtgacaagca atgggagcgt 2340601 cgttttgatt ttttcaacat ccccttcgac gtccctttct gcttctgcat cagtgccgtt 2340661 gatttcgagt ttggtgatcg tagtgataca cggaatgtcc agtagctcgg caagccgagg 2340721 cgccacttgt cctgatcctc cgtcaatggc aacatttccg ccgagaatca aatcaaactc 2340781 ctgatccttc atatagtggt ataaaacttg agaaatggaa tattggtcgg gttcatcaag 2340841 atcatcttct atgttgatta aaacagcttg gtcacaaccc atggcaagcg ccgtacgcaa 2340901 ttctttctcc gcttcttcac cgccgaccgt gacagcggtg atcgtgccgc catgcttttc 2340961 cttcagctgg atggcttctt ctatcgcgta ctcatcatat ggattaatga tccattccgc 2341021 tccgtcatcc tgaatctttc ctgtttcaat gacgattttt tcttctgtgt caaacgtccg 2341081 tttcatcagt acaaatagat tcatgatcat atcccctttt attcgccttt gaactgaggc 2341141 tttctttttt cgagaaatgc ctggatgcct tccttggcgt cctctgactc aaatgcttcc 2341201 ccaaatcgct ttgcttcaag ctttaagctg ccttcatagg aatacacctt gttggaataa 2341261 agaagttcaa gcaaagatgc cagcgtttgc gggcttttct ctgcaaactt agcggcaagt 2341321 gcttttgctt tttcaatcac ttctgcctca tctttcgctc caattgagac aagtccgaga 2341381 tcaagcgctt cttttccgga tatcggttct cctgatccga tgagctccag tgctttggct 2341441 gtaccgacat atctcggaag gcgctgtgtc cccgcaaaac ctggaatgat accgagatta 2341501 agctccggga gccccagctt agcatcttct gccgcgattc tgatgtgaca ggccattgca 2341561 agctccagcc cgcctccgag agcagcgccg tgaatcgctg cgataatcgg ttttggaaaa 2341621 ctttcgattc tctccattaa ctgctggccg cgctcagcga gcaatgagga atcctcattg 2341681 cctttaagcg atgtaaattc tttaatatca gcgccggctg agaaaaatct tccctcgccg 2341741 tgaatgataa tgcttcgtac gcctgcatct gtctcacatt gatcaagaca ggaagacagc 2341801 tcttctaata tccggcttga aagcgcgttt gccggcggat tgtgaatcgt caagactgcc 2341861 acaaattgat caaccgcaag tgaaattgca ttcataggac agaactcctt tacttattgt 2341921 gaattccgga taccaataat tctaaaacgc tgtttgaaag cgcaacgaga tcgtactttt 2341981 ggtcattcat cacccaagtt gtcacagttt cgtcaatcgt tccaaaaatc atctgccggg 2342041 cgaggcggac atcgaggcct tcttttattt cgcctgattg tataccttcc gtcaaaatgc 2342101 catccaaaat atttaagtag ccttttaata tttcgttgat tttttggcgc agctccaagt 2342161 tggattggcg gagctcaagc tgcgtgacaa tggcgagatt atggtcaccc gctaaaaggg 2342221 aaaaatgctt tgaaatcaca agcgccaatt tctctttcgc tgttgctttt tctttaatgt 2342281 cctcttccat ccgctcaata aattgaccca ttttttcttt gaaaagagaa attaaaatat 2342341 cttctttgtt tttaaaatag agatagatgg tgccgtccgc taccccggct tgtttggcaa 2342401 ttttggatac ctgtgactgg tggtagccgt tttctgcaat gacttctact gctgcatcaa 2342461 taatctgcat atactttggc cgtttttgct tcaatgttca tcgttccttc ctatagaaat 2342521 gaatgactat tcattcataa tttcatgata agaaggattt tcaggtttgt caagtttatt 2342581 cataggcgtt ctcttttttt atttgatatg atgattttcg gtttcttctt caagtaaacg 2342641 ccttcttaaa atttttccca ccgccgtttt cggcagctcc tttctgaact cataggcttt 2342701 gggcacctta tagggagcta gacgtgatct cgcaaaagcg tccagttctt ctgtatcggc 2342761 ttttgcgcct ttctttaata cgacaaatgc ttttactgtt tctcccctgt aggaatcggg 2342821 aacgcctgcg acaacaattt cctggatggc ttcatgttca taaagcgctt cttctacctc 2342881 acgcgggtaa atattgtaac cgccggcaat gatgatatcc ttcttcctgt cagcaatata 2342941 gaaaaagcct tcttcatcca tatagcccat gtccccggtg aacagccagc catctctcag 2343001 cactgcggcg gtttcctctg gtttattcca gtatcctttc atgacttgcg gaccttttac 2343061 aatgatttct ccatgctcat acggagcggc aagctcaccc gtctcttcag aatagatcgc 2343121 agcgtccgta ctcggccaag gacagccgat actgcccggc ttgttttttc cccagataaa 2343181 gttggcgtgc gtcactgggg atgcctcaga caaaccatag ccttccacaa gctttccacc 2343241 agtcaccttt tcaaatttct gctttacctc cacggggagc gcggctgatc cgctaagaca 2343301 gcttttaatg gatgacagat cataatgctg caattcaggg tgatgcaaaa ggccaatgta 2343361 aattgtcggt gcgccaggaa agagcgtcgg tttgtgtttg tcgatgattt taagtgtttc 2343421 gagcggatca aacttaggaa gaagaatcat ttcgaagcct agtttaatcg aatagttcat 2343481 gactgccgtc agtccgtaga catgaaaaaa tggaacgatg cccagcactt tttcagcgcc 2343541 ttctttcacg tcatacatcc aagcggcgca catttcagta tttgccaaaa tattttggtg 2343601 cgtgagcatg accccttttg gagctccggt tgttcctccg gtatactgga ggacagcgat 2343661 atcatgctca ggatcgatct tcgggattgt caggagttca gttttttcct gcttcataca 2343721 ggaagcgaac gtgtgaatgt tagctgtttt gtcaaagtcg atatgcactt tttgtttttg 2343781 cgtcagcggg taaagaatat ttttcggaaa aggcaaatag tcttttacac tggttatcaa 2343841 aatctggtcg actattgata acgttttcat ttttattgcc ttcgggaaaa gcaaatctaa 2343901 ggtgatgatt acacttacct gagcatctct aagctggtat tcaagctcat gctcggtata 2343961 aagcggattc gtctgcacca cgatgccacc ggcaaacaag acgccataat aagaaatcac 2344021 tgtttgcggg caattgggca gcataacagc cactctgtct cctttttgca ggccattgca 2344081 ctgcaaaaaa gctgcaagtt taagagcatc cgtcagaatg tcatgaaagg tgagtttttt 2344141 tccataaaac gatattgcgg ttttatcagg gaatcgtgcg gcggagtctg tcaggatgga 2344201 ttgcagggtt ttattcggca acggaagctc atgcgggata tcgttgggat actcggcaag 2344261 ccacggcttt tgagactgca taaaacctcc cctttcgatt ttagagatcc accttatcat 2344321 tatagcagat ggacggcaaa aaaaagaaaa agaaaggtaa atctttcttt ttctcataat 2344381 atgaacagat atataagacc aattaacaaa aagattcccg ctgcggcgag cagtattttc 2344441 gcaagctttt ccatctattc tccgtcccct tatattccgg ctgccaccac aaaagaaagc 2344501 ccgacagaaa tgacaaatga aataaagccg acagcccggt tatcattttc gatttcctga 2344561 tcaattttaa accgcggagt caaaaactca aaaataaagt agctgatcag aagcataaca 2344621 aacccgtaaa cgccccagcc gatcatttgc agcagcgaat tatgctggga gatggaatgc 2344681 tgaaatacgt ttgcgattcc caaaattttt ccgccggtcg ccattgccac cgcaagattt 2344741 cctttttgaa tctcttccca gtttttataa gccgtcacca gctcaaacac agtcaaaaag 2344801 aggacgaggc agagaaccgc gacactgtaa tatgccgcga tttccacaag ctcgttttcc 2344861 caaaaatcac tcatggccat actccctttt attttagttc aacaaccgta acgcctgatc 2344921 ctccctcacc tgcttcaccg aaacgggaac ttttgacgct gcggtggttt ttcagaagat 2344981 cctgtacgcc ttttcttaaa gcgccggttc cttttccgtg gatgattgac actcttggat 2345041 atccggctaa caccgcatca tccaagtatt tttcaacccg gctgagggca ttttcatagc 2345101 gttcgccgcg aagatcaagt tcaagcgata cgtgatagtc ctttcctttg accgctgtaa 2345161 tcattttttc tttttttggc tccggagctg atttgataaa ctccagatct ttttctttta 2345221 ctttcatctt taaaataccg atttgaacgt tccattcatt gccgcctgtt ttttcgagca 2345281 atgttccttt ttgcccgaaa gtgaggactt tcacctcgtc gccaggctta aagtcgcgtt 2345341 tttgcgtttt cggcttttcc ggtttcttgg acttttcaaa agcaggcata gcgccttcta 2345401 accgtttctt cgcgttaatc agctcgtgat ccttgaagga tttgtgttct tcttttatgg 2345461 tgcgcaattc atgaataatg tcctcggctt ctttcattgc cgcttttact ttttcagcag 2345521 cctgctgttc tgcctcttca agcattttgt cttttttgct gttaagctcg atgatttgct 2345581 gctgcagctc tttatgcagt ttttccgctt cttttctgat tgattctgtc tcagaaagct 2345641 cttcttccgc acgttttttg ctttgttcca gcgacgcaat catcgtatcg acttcgttat 2345701 gctcggccgt catttctgac ttcgcctgcc cgatgatatg gtccgggagc ccgaggcgtt 2345761 ttgaaatttc gaaagcattg cttcgacccg gcacaccaat taaaagttta taggtcggtg 2345821 acagcgtttc gatgtcaaat tcaacgctgg cattcatgac gccttctctg ttatagccgt 2345881 acgccttcaa ttccggataa tgcgtcgtag ctaacactcg tgcattggtg cgatgcacgt 2345941 catccaagat gctcatggcg agggccgccc cctcctgcgg atctgtccct gcaccaagtt 2346001 catcgaaaag cacaaggctg ttttcattga cctgttctaa aatgccgaca atattcacca 2346061 tatgggatga gaacgtactt aaactttgct caatcgactg ttcatcaccg atatcagcga 2346121 atacgtgctc aaatactgcc gcttctgacc cttcatctgc cgggatatga agacctgact 2346181 gcgccattaa ggttagcagg cctaacgttt taagggtgac tgttttcccc ccggtgtttg 2346241 gccctgtgat gacaatggtt gaaaaatcgc ggccaagctc gatgtcattg gcaacaacct 2346301 gatcaggcgg aagcaatgga tggcgggctt ttttcaaacg gataaagccg gtgtcgttca 2346361 taatcggttt tgtcgcttta accgcttttg catatctagc ttttgcaaaa ataaagtcaa 2346421 gcgtctgcag cacttgcaaa tctagaaata gctcctctgt atactctgcc gttttctctg 2346481 tcagcacacg caaaatccgt tcaatttctt gcttttcttt cactttcgcc tgctgaaggg 2346541 aattgttcat atctacaatc gcctgcggtt caatgaatag tgtcgcacca gaggatgagg 2346601 tgtcgtgcac aattcctcca tagctggatc tgtactcctg tttgaccggg atcacaaagc 2346661 ggtcattccg aatcgtaaca atcgtatcag acagcatttt cgatgcggaa gaggaacgca 2346721 gcatcgactc taaccggtct ctgactcttg attcgagtgt tctgagctgt gtgcggattc 2346781 ctcttaatgt ttccgatgca tgatcaagca cttctccgtg atcatcaatg caggaattaa 2346841 tgtcccgctc taaatcggac agcgtgataa gctgttcagc atgctgatgg atcagcggaa 2346901 tgtcgacacc gtcttcagcc atttgcgtga taaaatgttt catttgttta actgcataaa 2346961 gcaggcctga gatttcagtg aattcagaag gactgagaac gctgccgatt tccgcccgtc 2347021 ttaacgctcc tctgatatct acaaggccgc caaatggcgc ttggcctctc agccggataa 2347081 tgtcagaagc ttcgtctact tcatccagct gttttttgat ttcgtctata gaagcagaag 2347141 gcttaagctc gagaagcatt tcttttccga gcgatgaagc ggcatgccca ataacctgtt 2347201 ctttcacttt atgaaattca agagctgata atactttttg ctgcacgatt gtgtgagcct 2347261 ccttacttaa tcgttgcgct tcagaaatgc ctctacgtct ttaagcgacc gggcattcag 2347321 aacgtttttc gtttccgtcc atcctttgcg cgcggcagta acgccagttt tcatatcgtc 2347381 taacatctca atattatggg catcagtatt aatcaccaat gtaacccctt gttcgtttgc 2347441 tttcattaaa tgctctgtgc gcagatcaag gcgcgcaggg ttggcattga gttcaagcgc 2347501 cgtatttgtt ttcctcgcaa gctcaatcag ctgatcaata tcgatttcgt aaccggcccg 2347561 tctgccgata aggcgcccgg tcgggtgtgc gataatgtca acatgcttgt ttgtcagtgc 2347621 cgtctcaagc cgtttcataa tcacgtgttc cggctgatta aaactggaat gaatcgatgc 2347681 aataacgata tccatttccg caagcacatc gtcatcataa tcgagcgtac cgtcaggcag 2347741 gatatccatc tcaacgcctt tcaaaatacg gaagttttca aactctgcat tcagcgcgtc 2347801 aatttctttt gcctgctgct taagtctttc tgcagtaagc ccgttggcga cctttaaata 2347861 ttgtgagtga tcggtgatcg ccatgtattg atagcctttt ttgatgcagg cttcagccat 2347921 ctctctgatc gaaaatgcgc catcgctcca cgttgagtgc atgtggagat cacctttgat 2347981 ttgcccgagc tctatcagtt caatgctgtc gctgtaggtt tccacttcct gtccgctttc 2348041 acgaatttcc ggcggaatca gcggcaggcc gaagtgcgca taaaattcac gttcactcgg 2348101 aaatgttttg atctctccgg tttcaactgt ctcaacgccg tattcactga tccgctcgcc 2348161 gcgttctttg gcgatttggc gcatcttaat attgtgatcc tttgatcccg taaaatgatg 2348221 gagtgttgtc ggaaactgct cttccgtcac aagacggaaa tcgacgcttg tttcatattc 2348281 aaaggaaagg atgacggaca ccttcgtatc tccgcttgcg atcacgcttt tgatgtttgg 2348341 cagctcaaga agctgctctc ttacttcagc cggatgatct gtagcaatga tataatccag 2348401 atccttcacc gtttcccgcg ctctgcggag acttccggca cgagaaaatt tgatgatatg 2348461 cgtaaattga gaaagatgct cctcaatttc ccgcgcgatc cggagggcgt agccgatcgg 2348521 gaaccgttca ggctgttttc cggcttcccc gagcgcctgt aatatttttt cttccgattt 2348581 tttgccgaag cccgcaagac cctggacctt ttgctgctca caggcttcct tcagagattc 2348641 tgcatcgtgt acgccgagct ctttatacag ctttgcgatt tttttgccgc cgagccccgg 2348701 cagcttcaat aaaggcacga gtccttccgg cacttctttc tgaagcgatt cgagcgtgct 2348761 tgactttcct tcatctatat actctttaat gacgctgtac gttccttttc caatgccgga 2348821 cagcgacatc atatcgtcca tttctgataa gcttcggtcg tcctgttcca gagctgccgc 2348881 cgcttttcgg aaggcggata ctttaaacgg gttgtcccct ttgagttcca tatagactgc 2348941 aatggtttca agcagccgga taatatcttt tttatgcata tcataacccc cagacgttca 2349001 catatgtttc catcatactt gaaaaaaact tctccggaca agagaagttt ttttatgccc 2349061 cgtactgtgt ccacagctct tgtaaaagcc ctgacaagta cggtgtatgg ttaatgatca 2349121 catttgcgag agacgattgc cccatcattt gctgcaacgc gtctaccggc agaacggatg 2349181 cgacatacag cagcacaaat gtaaataaat agacttctag aaaaccgaga acggctccca 2349241 gcatctggtt gatttgttta atcaccggaa tgccggctac aatactcagg aacgagccga 2349301 tgattctcag taagatttta gcaatgataa ataaaacgat aaacgcaatc gcattatagt 2349361 acgctgcttc caaattcccc gtaaaaaaag aaagagccgg ctgtcccgct gaaaaatcgg 2349421 gtgcgggaat ccaatgtaaa tgcggtgcca cgtttttata gaataaagcc gcaaaggcaa 2349481 ttgataaaat aaagctcgtc aagcggataa actgcaggat aaaaccgcgt tttaacccca 2349541 gtaaagtccc catcaggagc aagattaaga tgatgatatc tagcatagtt gttcaatcct 2349601 tttctttaag ctgacgctcc agtttttcac atttctcttg taatttgaca taatcgtgca 2349661 ccacatttac cgctgtcagc actgcaagtt tatttatatc aaggtatgga tttttttcat 2349721 tgatttctct cattttatca tcaacaattc cggcgacata cctcatatgg gctctgcttt 2349781 cttcaccgac aatcgtgaag tgctggccgt aaatgtcaac ggttgttttt gtttttttgc 2349841 cgtcagacaa cgtttctcct ccattccgcg agaatcctag ttcttatcat aacacgttta 2349901 ttaaatgaat ggaaagacga gcctcccgct gttatgatac actggtatat acagcgaaaa 2349961 gtgtaaaaaa aggagattat tacgtgtccc attcagtgat aaaagtatcg ttgtctgcta 2350021 ttgaccaaat gaaaatgacg tacagcggtt cacttacagc ctctgttccg cagggagccg 2350081 tttttcaggc aaaaccgccc ggctgtacca ttacagcata tcaatcaggt aaggtcttgt 2350141 ttcaaggaaa aaacgctgcg gcagaatccg cgcgctgggg aacagcagag cctcaggaaa 2350201 agaagaaaac ggccaaaaag ccggctgatc cccgctatgc ccctccggca gatatcgccg 2350261 gaatgtctgt tatcggttct gacgaagtcg gaaccggaga ttactttggc ccaatgacgg 2350321 ttgtatgcgc gtacgtcgac aaaaccatgc ttcctttaat gaaggaactc ggtgttaagg 2350381 attctaaaga tttaaaagat ccgcaaatca tcgagattgc ccgaaacctg attaaaacca 2350441 ttccgtacag cctgctggtg ttaaagaatg aaaagtataa cagcatgcag gaaaaaggca 2350501 tgagccaagg gaaaatgaaa gctttgctgc acaatcaggc gatcacacat ttattaagaa 2350561 aattggatgg agtaaagcct gaagccattt tgattgacca attcgctgag ccaggcgtct 2350621 acttcaatca tttaaagggc agagacattg tgaaggagcg gacctatttt agcacaaaag 2350681 ctgaaggtat tcacctggct gtcgccgctg cttcaatcat tgcaagatat tcatttttaa 2350741 tggaaatgga taaactatca cgcgcggcag gaatgacgct tccaaaaggg gccggtccgc 2350801 acgtcgatga agcggccgcc aagctgatcc tcaaaaaagg ggcatctgca ctcagaacct 2350861 ttacaaaact ccatttcgcc aatacgcaaa aagcgcagcg ccttgctgat aaaaaacgtt 2350921 catagaaaaa agcttgcaga tttctctgca agctttttta tcagcctctt aaaacagctt 2350981 gatatgtgtc ttctaacgct ttcagcactt tgctgtgcgc ctttgtcact tcttcttcag 2351041 tcagtgtttg ttcaggattg acatactgga gtgagaaagc gactgacttc ttgccttcct 2351101 ccatatgctc tccttcgtat acgtcaaata cggttacctc tttcagaagc ttgcccccgg 2351161 cctctttaat gacgctctcg agctgtccgc ttgtgacggt tttatctgtt acaagagcga 2351221 tatcacgtgt cacagacgga tattttggaa tcgccgtgta aacaagcggt gctgtttctg 2351281 ctgcgagcaa cgcatgaaga tcgagctcaa atacgtatgt ttcctttata tccagttctt 2351341 tttccaatga aggatggact tggccgatga agccgatcag agaaccattc aataaaatgt 2351401 tcgctgttct gcccggatgc agctgtttgc gttcagactg tacaaattca atgctgtcta 2351461 ggacgttgag tttgtctaac agcccttcca caattccttt gacaacaaag aaatcaactg 2351521 gtttcttttc accctgccat agctgcttgc gccataatcc ggtaacagct cctgctacgc 2351581 gttctgtttc aacaggtttt gtgtcctctt ccttcgttag gaaaacggag ccaacttcgt 2351641 acagtgcaac tgagtcagtc tgcctcgcaa gattgtaaga aacagaatca agcagatttg 2351701 gaacaagact gtgtctgaga atgcttcttt cttcactcat tggaagcgca agcacagtat 2351761 tcagtgattt ttcaatcgca aacgctgtcg ctttcttctc gtttgtcagt gagtaagtga 2351821 tggcttgtga taagcctgcg ccttcaagga agcgtctgac tttacggcgt tttgcctgat 2351881 atggcgttaa tccgcctgta gttcccgctg tctcaggaag cgtagacgga atgttatcgt 2351941 agccgtacag tcttgccgct tcttcgatta aatcctcttc tattgtaatg tcaccgcgcc 2352001 gtgatgggac agtcacaacg agaagatcat ccgcttcacc gaccgtaaaa ccgagacgtt 2352061 tataaatgct gatcagttct tctttactga tcgtcaggcc tagaacgctg ctcactttgt 2352121 cagcagatac gtgaatgtta tttgcttcga ttgtcaggtg atcttcctca accgttccag 2352181 caagcacctc accgccggca tacagatgga tcagctgcgc agcccgttct gctgcaagac 2352241 gtacgcgtgc cggatcaatt cctttttcaa atcttacgct tgattcactt ctcaaaccaa 2352301 ggtctttgga agccttgcga accttctgcc cgttgaaata cgcagcctca agcaaaatgg 2352361 ttttcgtatc ttcctgaacc tctgactctg ctcctcccat gacaccggca acggcctgcg 2352421 ctttcgttcc gtttgtaatg acaaggtgat cggcagacag cttacgttct tgatcatcaa 2352481 gtgttacgat catttcattc tcagctgctt ttcttactac gacttcctta gagccaaatc 2352541 tgtcataatc aaacgcatga agcggctgtc cgtattccaa caggacaaaa tttgtgatgt 2352601 caacgacgtt gttgtgcgga cgaatgcctg cattcatcag ctttgtctgc atccaaagcg 2352661 gtgacggagc aatcgtgaca tttttaatga tttttgcagt gtacagcggg ttcgcttctt 2352721 gatcttcaat tttgactgaa atgtaatcag acgcttgttc tgaagcagcc gggtaatccg 2352781 tttgcggaag ctttacctca gtgtctaaaa tcgccgcaac ctcgtaagca acaccaagca 2352841 tgttcatggc atccgcgcgg tttggcgtta aacccagctc aagaatcgca tcgtcaagct 2352901 gtaaagccgc taaggcatcg cttcctgttt cagcgtcatt cgggaatacg aaaatgcctt 2352961 ctgcatactc cttcgccaca agtttgcttt cgataccaag ctcctgtaag gaacagatca 2353021 tgccgtttga ttcttcaccg cgaagcttgg cttttttgat tttgaaattg cccggcagca 2353081 ccgctccgac tgttgcaact gcgacttttt gtcccttatc cacattcggc gcgccgcaaa 2353141 tgatttgtac aggggcttca gctccgatat ccacaaggca cttattcagc ttatcagcat 2353201 tcgggtgctg ctcgcgctcc agcacatggc cgatgacaac gcctttgatg ccttctcctt 2353261 tgtattcaat tccttcaacc tcaataccgg ctcttgtaat tttttcagca agaacagccg 2353321 ggtccatgcc ttttaaatca acataatcct ctaaccattt ataagaaaca aacatccttg 2353381 catcctcctc ttacgcctgt ttaaactgcg aaataaatct gacatcgttt gtatagaagt 2353441 ggcggatatc atcaatgcca tatttcagca tcgcgatgcg ctcaacaccc attccgaatg 2353501 cgaagccctg atattccttc ggatcaaagc cagccatttt aagcacgttc gggtgaacca 2353561 ttccggcacc gaggatttca atccagcctg ttcctttaca tactgagcag ccgttcccac 2353621 cgcatttaaa gcatgtcaca tccacttcta ctgaaggctc agtaaacggg aagaagcttg 2353681 ggcggagtct gatttcacgg tcttgcccga acattttttt cgcaacaagt tcaagcgttc 2353741 cttttaaatc actcatgctg atgtttttgt caacgacaag cccttcaatt tgcataaatt 2353801 ggtgagagtg cgtcgcatca tcgttatcac ggcgatatac tttacccggg caaatgattt 2353861 taacgggacc tttgccttca tgcttttcca tcgtacgtgt ttggacagga gaagtttgcg 2353921 ttctcatcaa agtttcctct gtgatgtaaa agctgtcctg catatcgcgc gctgggtgtt 2353981 ctttcggaag attgagcgat tcgaagttgt agtaatccgt ttcaacctct ggcccttcct 2354041 cgactgtgta gcccataccg ataaataaat cttcaatttc ttcaatgaca acagtgagcg 2354101 gatggcggcc gccgactgca acagggttcc ccggcagcgt gacgtcaatt gtctgtcctg 2354161 caagcttctg tttcatttcc tcttcttcaa gcttctcgtt tttgtcagca atcgcattgg 2354221 caatacgctc ccttacttcg ttcgcgagcg cccccatttt tggacgttcc tcagcagaaa 2354281 gcttgcccat tccgcgcagc acttctgtaa tcggcccttt ttttccgaga tattgcaccc 2354341 gaatatcatt gacaaccttc aatgagcttg ccgcttctac ttgttctaaa gcttcttgtt 2354401 ccagctgttt tagcttttct tccattttgc atcctccttt tatgtaaaca aaccgtcata 2354461 tgtctttgga aaataaaaaa aacccgtccc ttgtacaagg gacgagttgt ggccgcggta 2354521 ccacccttat ttcagacaga ctgatgctgt cgtcagcttc attgacataa cggaatcaga 2354581 ttccggttca cctttacgcg cagtgtacgc ggtcccggcg acaactcaag aggtgaagcc 2354641 aatttccggc tgcgttaaaa atgctctcag tcagcggcat tttctccctg gaaagcagtt 2354701 gatcagaaat tgaggtcctc tgtcacggtt tttgaaatat tatgttctat tatagagaaa 2354761 tccaacgctt ggcgcaacac tatcctcgca agtgatacac gaggatggca gccgcaaccg 2354821 caacgtttag tgattcagcc tgtccgtaaa gcggcacgta caggttcaaa tccgtttttt 2354881 ccagcaatgc agcatctacc cctgcacctt catttcctac aatgagcgca aaggattcag 2354941 actgaggaat ctcctggtaa ggcgctccgt tttgcagcgc cgtgccgtat acttttacgc 2355001 cctctgcctt caattcgtcc acatatgaag gcaggtttct tctcacaaca ggaatatgga 2355061 agtgagatcc ttgagcagat cgcagtgttt ttccgttaaa ggcgtccgcc gtgccgtcac 2355121 cgagtacaac cgcatccaaa ccggccgcat cagccgttcg aatcattgtg ccaaggtttc 2355181 ccggatcttg aacagcgtca atcagcagca ccttgcgtgc cgttgccagc ttttcttcag 2355241 gcatatggca cacagcggca atctgctgcg gcgtttcggt ttcagtcaca gctgaaaacg 2355301 catcttcact cagcatatag cactggatac cagtctcaag atctgaagga atcctcgttt 2355361 catcctttac aaggatttct ttcacaatgc ccgggctttt caacgcctct tcaacgaggt 2355421 gttctccctc tatcagaaat gtatttgttt ttgttcgttc tttttttgtg tgaagctttt 2355481 tccaatcctt cactttttgg ttttttgccg attctatttg tttcactgtc tatgtggcgc 2355541 tccttttttt aacatgatgt tattatatcg caagaacagc acataataaa ccaggtgcag 2355601 ggttagaata tacgtattac attttagaaa aaggagcgtt ttacatggat cttaatttac 2355661 gtcatgccgt cattgccaat gtcaccggca ataatcagga gcagcttgag catacaatcg 2355721 tagatgcgat tcaaagcggt gaagaaaaaa tgcttccagg gctcggcgtt ttattcgaag 2355781 tcatttggca gcacgcatcc gaaagtgaga aaaacgaaat gctgaaaacg cttgaaggcg 2355841 gattaaaacc cgccgaataa gacatgaaac cgggtgacag cgcccggttt ttttcttata 2355901 taataaaaac atgatgaggg ggaacgccat gtttttacag ccgttattag cgaaaaaaat 2355961 tattgctgaa gttaaaaaaa tgtacgaacg tgaagtcatt attgtaaaca cggacggtct 2356021 tattatggca ggcacaaacg atgagcgtgt cggacaattt catgagggag cgcttatctg 2356081 cgcaaaagaa agacgcagcg tgattattac aaaagaagat gaaacaaggt taaaaggagt 2356141 gaaagcaggc ataaacctcc ctgtattttt tgaccatgat gtgattgccg tcttcgggct 2356201 gacaggtgag cctgcagaga ttcagccatt cggagaactg cttcgaaaaa tgacagaact 2356261 gttcattaag gaatcgcggc acttagagca atcccagtgg cgtgagagaa tgctggagtc 2356321 ctttatgatc gattggctgc aattaaagga gtggtctccc agttttcttg agaaagctca 2356381 gcttcttggt gttgaccttt cttcccggcg ccaaatgatt cttattcagg ggtatgagtg 2356441 gtcacctcat gatattgaac aaatggcacg cagctggaaa tcctcgtacc ctgcggattt 2356501 gttcatcagg tggggaaatg aacggatttt gattaatcat gaagtgccgc agcatgaaca 2356561 aagggatcgg cttttgcgga aaatccttca catttgttcg tttgccaata ccgcaagcag 2356621 ccaatataca gcagctggcg ccggaagggc tgtcgcaagc tccagcctga cagattcata 2356681 cgagcaagcg gaaaaagcgc tggctgtcag ccttaagcga aaaacgccca tatttgaaga 2356741 ggatctgaag cttgatatgt gtctgacgga gatcagcccg ggaacccgaa acgaatttcc 2356801 gcaaagagta ttaggaaagg cgctagagca tcaggaactt atgaatacga tacggacttt 2356861 ctttcatcac gatttgtctt tgaaacaaac cgctgaagac atgcatatac acatcaatac 2356921 attgcgttat cgtctggcta aggctgaaca gctgacggga ttacgttttg accgtaccga 2356981 ggacgtcgtc acgatgtacg tcgcactcta ttttttagat caagatacaa aatagagaga 2357041 gtttcagttt cattttttgt atgtttctcc atggaaggct ttgctttttt tcttttacaa 2357101 tagattgaaa gcgttttttg acagggggat gggtgaaatg atcaccaagg atgtaaagga 2357161 gcagctgatt caggtctccg gaccagaaaa ctttgatgac tcgaatgccg gccgtctcgt 2357221 ctattcatat gatgcgacgc ctcagtatca gtctatgcct gatgccgtga ttgctccgag 2357281 gaatactgat gaaatatcac gcattttaac aatttgcagc gaacatcgag tgccgatcgt 2357341 tccaagagga tcagggacaa acctgtgcgg cggcacgtgc ccgactgaag gcggacttgt 2357401 gcttctcttt aagcacatga accagattct tgaaattgat gaagaaaatt taactgccac 2357461 agttcagccg ggcgtcatta cgttggatat gatccgggca gttgaaagca aaggtttatt 2357521 ttatccgcct gacccgagtt ctatgaaaat atcaactatc gggggcaaca tcaatgaaaa 2357581 ttccggcggg ctacgcggat taaaatacgg tgtcacccgc gactatgtta ttggactgga 2357641 ggttgttctc gcaaatggtg acatcatccg caccggcgga aaactcgcaa aggatgtggc 2357701 cggatacgat ctcacacgtc tttttgtcgg ctcagaagga acactcggca ttgtgacaga 2357761 ggcaatcgtc aaactcgttc caaagccgga aacaaagaag acgctgcttg ccctttatga 2357821 aaacatcgat gccgctgctc aaacggtatc ggacattatt gccgcaaaaa ttatacccgc 2357881 tacgcttgaa tttctcgatc agcctacact attggtgatt gaggattatg ccaaaatcgg 2357941 acttccgaca agcgcaaaag cagttctgtt aattgaacaa gacgggccat ttgaaactgt 2358001 tgaacgggat atggaaaaga ttgaggcgat ctgcaaaaaa ggcgacgccg tatccgttca 2358061 gaccgcacaa acagaggagg aagcgtttgc cctgactgaa gcccggcgtt ctgcactttc 2358121 tgccctagcc cgcctcaaac cgacgacgat tttagaggat gcgaccgttc ctcgctcaga 2358181 aatcgccaat atggttaaag cgattaatga tattgctgct aaatatgata tttccatctg 2358241 cacctttggt catgcgggag acgggaacct tcacccgaca tgcacgacag acataagaaa 2358301 taaggatgaa atggaacgtg tcgaacaggc ttttgccgag atttttgaga aagcgattga 2358361 acttggcggg acgataaccg gagagcacgg agtcggggaa atgaaagcgc cttacttgga 2358421 aatgaagctg aaaaaagaag gcattgatgc gatgaaagcg ttgaaagcgg catttgaccc 2358481 ccggaacata ttaaatcccg gcaaaatgtt tgcgaaagat gccagaaaac gtgtggtggc 2358541 ggaaagatga caacagaaaa agaaatgaaa cagatccaaa atgaatttaa agagcgtatg 2358601 gatgaaggag agttattaaa ttgtatgcgc tgcggcttct gtcttccttc ctgtccgacc 2358661 tatatcgaat cgggatttca ggaaacacac tctccgcgtg ggcgcatcgc cttaatgaaa 2358721 gccgtagccg acggtatgat tgaaccggat gaagatgtcg aacggtcgct gtcactttgc 2358781 ctcggctgcc gcgcctgtga gcctgtatgc ccgtctggcg tgaaatacgg gcagctgctt 2358841 gaggaagcca gagatattat ccaccaaaat aaaaaacact ctcttggtga acgtgtcatg 2358901 cgaaagacgg cttttcacga gctgtttccg catcaaaacc gcatgcgctc agctgtaagc 2358961 cttatcggtt tgtatcagcg ttcaggactg caaaccgctg tgcgaaaatc aggcatgctt 2359021 cgggtcctgc ctgagcattt gcggacgatg gaagctgttc ttcctgatgt tccaaaaagc 2359081 aaagacatga aacatcggcc gcgtttcctg ccttccattg gccccatgaa aaaacgggtc 2359141 gccttttttt cgggctgctt aatggataca atgtttttac cgaccaataa cgccacattg 2359201 aagcttttac agctggcagg ctgcgacatt gtcattccgc ctgaacaggc ttgctgcggg 2359261 gcgcttcatg gacacagcgg tgaaaaaaac acagggaaag agctcgcgaa acaaaatatc 2359321 gctgctttcg aagcattaga cgtggatgca gtcattacaa acgcaggagg atgcggagcc 2359381 tttctcactg aatatgatca tttgctgaag gatgaccctg agtggtcgga acgggctgcc 2359441 gcttttgttc aaaagctgaa ggatttttct tctgttttgg ttgaactcga tttccatcaa 2359501 atggatctag cactcgagac gcctcaggtc gttacctacc aagattcatg tcatctaaga 2359561 aatgtgatgc atacgtcact tgagccccgc cagcttctta aaagcatcaa aggggcggaa 2359621 ttcaaagaaa tggagaaagc agacagctgc tgcgggtcag cgggaattta caacatcgtc 2359681 gaagttgaaa tgtctatgaa aatactggac agcaaaatgg ctgccgtcaa agcaaccgaa 2359741 gcgatcctca ttgtaacagc aaatcctggc tgcctgctgc agatgaagct cggcattgaa 2359801 cgcgaaggac taagcggtaa agtcagagcc gttcacctgg ctgatttgct attagaagca 2359861 gccgggcaca aaacatcatg agaaagccca aaacagacat tgttttgggc ttttgtgcgt 2359921 tattccatcg gactgcaaat ttcgatataa tgtccatccg gatcagcgat ataggcgacc 2359981 gtctgccccc atggtttcac tttcggctcc ccgataatcg atacgccttg ttctctcatc 2360041 cttttgatga ccgcttctac attttcagta acaaacccga tttcaaatgt gtttgaagca 2360101 gatgtatccg gaatgtccag cgccgtgatg tctctggcgc tttcccgggt attaagcgcc 2360161 aatatcgtag accctgtatc aaattcgaca tacgtgccgt gttcagcacg aatcggcagt 2360221 cctaaaatat cccggtaaaa aatgaatagc ccgcttgctg tccgatacgt atagaataag 2360281 atatttcatt gatagattca ttgccaaccc ctctcagcat tttcaatagt ccttctagcc 2360341 cggtatagat gcttccatcc ttaagctcgg atctttccac atctgcgccc attttttcac 2360401 agccgccacg ataatgatga agcctaacac cagcatgatg atagataata cgccattcaa 2360461 tacactatat cctgctgctt caggattgag atacacattg cgcaccatcc aatagcccgc 2360521 ataattgaca gtgacatata aataggcaag cgggataagg caagtcagaa tgtaccggcg 2360581 tttatcggcg attttcagca cgatcgtcgc tccgataatc agccccactg aagccatcag 2360641 ctgattagaa acgccgaaga gcgcccaaat ggaaccgata tctcctgaat acagcaagta 2360701 cccccacatc aaacaggcaa gcgcgctggc aaatacagag cccggaatcc agtctgtttt 2360761 cttcagcggc ttatacacct ccccgaagaa gtcctggatc aaataacggg cgacacgtgt 2360821 gccggcgtca atcgctgtta aaataaagac cgcttcaaac ataatgacaa attggaaaaa 2360881 gtatgaggcc aaatggctga aaaacggcat tccggtaaaa atataagtca tccctaccgc 2360941 aagcgtgacg gctccccctg ttcttccttc taagtccaaa ccgatttccc cgctcaattc 2361001 aggcaaatgt acgacattca tgccaagcgt acggaaaacc tcaggcgtgc tgttaatcgc 2361061 aaagtaatca gcaggctgta aagcggtcgc tgcaatcagc gccatgatac cgacaagaca 2361121 ctcaacaagc attgcgccaa acgcaaccgg cttcatatca ctccatttat tcagcatttt 2361181 cggtgtcgtt cctgagccga caaaggcatg gaacccagag atcgccccgc aggcgatggt 2361241 tattgagatg aacggccaga caggtcctgc cagcaccggc cctccgcctt ttacgaattc 2361301 tgtaaacgca gggaacggaa tggacggatt gacgacaaac acaccaacaa tcaaagcgat 2361361 aaaaacaccg attttcataa agctgcttaa ataatcacgc ggagccagaa gcagccaaac 2361421 gggaagcgca gccgcaaaaa acgcataaac aggaagcgcg attgcaagcg ttttcgtatc 2361481 tagcgttaaa aagtcaccga gcgcggtagt ctgtacccat ggaccgataa agactcctgc 2361541 cattaaaaag agaaagccga ccgttgaagc gagctttaaa tttcccgttt tcttataaaa 2361601 taagcccaca cccatcgcaa tcggaatcgt aatccccacc gcaaatgttc cccatggatt 2361661 acgttcaagc gcatgcaaga caaccatcga caggcccgcc attgtgatcg tgatgataaa 2361721 cagcatggac agtcctgtac aaaatcctgc aacagggcca agctcatcct tcgccacttc 2361781 cgacagcgat tttccgtttt tgcgcatcga tgcaaacaac accacaatat catggacggc 2361841 tcccccaatt accgccccga ttaacagcca caataatccc ggcaaatagc caaactgcgc 2361901 cgccagaatt ggtccgacca gcggcccggc cgctgcgatc gcggcaaagt ggtggccgaa 2361961 cgaaacccat ttatttgtag gcacatagtc tttcccatcc tcaagcgcat gagcaggtgt 2362021 tggcttgtca tcattcactt tgagaacctt caccatcata aatgttccgt ataaacgata 2362081 ggcaatagcc aaaatacaca ttgatgctat cacaattgta accgcattca ttttctccca 2362141 tccccttttc tgtttttcat aaatatatca taatttcatg gtgaaaagcg gtcatttttt 2362201 cctatacaaa aagccggctg gaatgggccg gctcgtggca gttgaaagac aagccggaga 2362261 gaaatctccg gctttgctat tcttatgact gttttttcag gcggatcaca ttccaggaaa 2362321 gcggcgtgaa atgagcagtt aagccgtttt cgctgacaga cgatgatccg ttggaatgcg 2362381 gaacgacatt ttttctgtta tgctggtttg ttgctttgat atcctgatgc tcaagtacga 2362441 tgtgctctgc gatttggtag gattcaaagc ctctgagcga aatctccgtc tccatctgat 2362501 cctcagcctt gtttaccgca aaaatagtga gtgtttcttc ctcttcagag tacacaacag 2362561 cagcatcaac atatggcaca tcagtgaaat cagaacaatc gtacttagga gaagaaataa 2362621 gcggtttcag tgactcgccc cttccgtaaa cagaagcatg catgtatgga tagaaaatcg 2362681 gctgtctcca tgcttctccg cctttttccg tcatgatcgg cgcgatgaca ttaacaagct 2362741 gtgcaagaca cgcaattttc acacggtctg cgtgctgcag catcgtaatg agcagagagc 2362801 cgactaataa ggcatcttca aaattgtaaa tatcctctaa aatcggacgc gcagtgatcc 2362861 acggctcgac ttttttatca gcctcatttg agtggtacca gacgttccat tcatccagag 2362921 agagattgat agttttcttg ctgcgtgttt ttgcttttac atagtcacag gtcgcagcga 2362981 ctgatttgat aaaatgatcc aaatccatag aacgtgccaa gtagtttggc agattgttat 2363041 cccggtttcc gtagtaagtg tgaagagaga tatagtcgac atgctcatac gtatgctcaa 2363101 gcaccttcgc ttcccaatcg ataaaggtcg gcataccgct gtttgagctg ccgcaggcaa 2363161 cgagttcaat tgatgggtca acccacttca tgacctttgc tgtctctgcg gcaagccgtc 2363221 cgtattcatc agctgttttg tggccgatct gccatggtcc atccatttcg tttcctaagc 2363281 accatgtttt gatgccatac ggctgttcat agccatgcga tcttcttaaa tcactccagt 2363341 aagagccttt cggatggttg caatattcaa cgagattacg ggcggcatct atgcctcttg 2363401 tgccaaggtt gacggccata ttgacctcag tgttcacctt ttttgcccaa gataaaaatt 2363461 catttgttcc cacttcattg gtttctgtcg tttgccatgc caagtcaagc cgtctcgggc 2363521 ggttttcgac tggtccgaca ccgtcctccc agttgtatcc ggataaaaag tttccgcccg 2363581 gatagcggat gatgggaacc tgtaattctt tgatcagcga ctggacatct tttctaaatc 2363641 catcttcatc cgcttcaggg tgatcaggct cgtatatgcc ttcatatacc gcacgaccca 2363701 tatgttcgat aaacgagcca taaatccgtt tatctacttc accgatttta tattctttgt 2363761 ctacaatcat tcgcgctttt ttcatcacac gtttcctcct tcattaacct ttgactcccc 2363821 ctaccgtcag gccggagata aagtactttt ggaaaaacaa gaaaatgata atcaccggca 2363881 aaatcgcaaa tactgagccg gatataagca tgtcgtaatt atttccataa gggctcagca 2363941 agctggacag ccctattgga agcgtaaaca tttctttcga ccgaagcaca atcagcggcc 2364001 acaagaagtt gttccagctg tttaaggact gaaggataat catcgcaccg aaagccggtt 2364061 tcatcagcgg tgccataatc ctgaaaaaga tgccgaattc cgtacagccg tccatccttg 2364121 cagagtccag cagatctctt ggaaggccaa gagcatattg cctgaaaaag aaaacagcaa 2364181 caggtgaaac gataaacggc aatatgacac ccgtatatga atcgatcaag tgcagtccga 2364241 cagtaagttt aaacagagga agcatcatca cttccagcgg aaccatcata ataatcagca 2364301 caagaacaaa gatgatattt ctgcccttaa aatcataaac cgcaagcccg tacccgatca 2364361 tcgaagaaaa aaacagagtg agcacagtcg taaaaagtcc gagtacaaga ctgttaaaaa 2364421 accatttgaa ataaatgctg ccgccattaa acagaaatgt gtagttatca aaactcatca 2364481 cttttggatc aatatcaaga ttcagcccca cacgcaaaag ctcagatgac ggctttaatg 2364541 atcctaaaag caaacagaaa atcggaaaaa gatacaatag gctcagcatc ataaaaaaca 2364601 gggtcagcgc aattctataa acgctaaact gaggactgtg ccgcaacatt tatccctccc 2364661 ccttaaacga gcctgacagc tttaatgaaa tcaggctgac aacaaggatc acaatcaaaa 2364721 gcacaatgcc gatggccgct ccgtatccca tttcattgta ggcaagtccc tgctgataca 2364781 aatatccgac aagcgtcaga ccaatattac ccggggaatt attctgccaa aggacgtagc 2364841 tttcctcaaa catcctgaag ccgccgatga tgctgatggt cagcacatat acggttacag 2364901 gcttgagaaa cggcagcgtg atgtgcagaa attttttcat tgtattcgcg ccgtctatat 2364961 cagcggcttc gtacagctct ttcggcacat tttgcaaacc tgctaaaaag taaaggatgt 2365021 tgattcccat ccatctccat gaagcaagca gcaccatcaa aaacatgccg gtatgttcat 2365081 tgttcatcca gttctgaggt gaaaagccga gtttaagtag gatggaattg gccagagacg 2365141 tttccatttc tccgaagatc agccgaaaaa tgatccccgc gacaatggtt gaggtcaatg 2365201 ccgggataaa taatgctgat ttaaatatat ttctaaattt gaccagcttt gaattcagga 2365261 atatggccag aagcaatgga acaggaatca gcacgatcag cgtccaaaag gtgtattcca 2365321 gcgtattcca aagggcggta tagaacgtcg ggttgtttag cgctgtataa ttagacaatc 2365381 cgacaaagga cacctctccc ggcaaaattc tttggaagct catgatgaag acactaatga 2365441 tggggtatag aaaaaatacg agaaaggata aaacgaatgg cgctgtaaac agatagggcg 2365501 ccgctttttt tgaataaaac agatctcgcc agcctgattg tttcgcagct gaaggaacgg 2365561 gatgaaccgt tcccgttttc acaggtttca tgagaacctc cccgctttca ctttttgaat 2365621 gggattctat ttctgtttca gttcacctgc cgctctgtcc aaggcttgtt taggcgtttt 2365681 ttgctgagat ttaagcgcgt cgaacaatac gcttctgttg acaaggtctg aagccttggc 2365741 aaaatcctca tgtaaataaa ttggattgat ttcatccttg atatcgagca gcacagaaaa 2365801 aatgcctgtt ccgttttgga agtaatccgt gtatttgttt ttctctttca attccttgga 2365861 gctccaaaca tcccagcgaa gcgggtcaaa gccgagtacg ctccagagtt ttttatttcc 2365921 ttcttcagag cccttcgcaa aggccaaaaa ctcttttgct aactcaacat gcttggattg 2365981 cttcggtaca acagttgccg taccgcccaa acctgccgag cggtcgcccc cctctttcca 2366041 tgccgggagc ggtctgatgg caatcttccc tttcagatca ggcatataat cgataaatct 2366101 tcccatatac caaatcggca tgagaactga agcagctcct ccttggttca taaagccgta 2366161 gtattcttca ctgtgatgcc cgccgcccgg cgcaggaatc atcgttttat cattgatcat 2366221 gtcttttaaa tattgaagtg tttttacgtt ggtgtcatta ttgaggatca gcttgccgtt 2366281 tttatcaaaa tagcctgagt tttgctgtga aatcatagat aagaacgttg cggaatcatt 2366341 tgtttccacc gttcccatcg gcttcccggt cactttgcgc actttctgtc cggctttatg 2366401 gtaatcatcc catgttttaa tatcgtcagg attgacgccg gcttttttca tcacatccat 2366461 gttataaaac atgaccgttg tccctacatg tgtatcgagt ccgtaaagct ttccgttttt 2366521 gctgtacaat gtcagccgcg cctcaacgaa tttatcgcga tccttttcaa tcagcggagt 2366581 caagtcggca agcggtatgt cagagccctt caaaaagttt gaaaaacggg ccaattcgac 2366641 atctgcaata tcaggaacgc cttctcccgc tattagggag atagataagt tatcgtgcat 2366701 ttgtccatat ggataaacga ccgtattcag cttaattttg cggtcaggat attttttgtt 2366761 ccattccttc accatttcca catagaactg ctcatgaagc ccgttaaatg tccaaaaggt 2366821 cagctcagtt tcacccgatt tgccggatga tttttctgct gaacacccgg caatgactaa 2366881 tgtcagcaac atcatgagca caagaaaaca gacagtcatt tttttcatct gcgttacccc 2366941 ttccattcga ggtgcgggct attcatatag accatggttg atcagcgttt tgttttcatt 2367001 gatgattctt aatccggtgc atcggtctct taaggtgtgc gcgtgtctga aggcattttt 2367061 gacggaatcc tgcccgacac cgatttcgtc aaaatacgca gggcctccgg ctgatctcag 2367121 ccaatcagcc agcacttctc ctctcgggag tgtttgataa gccgattgga tggcttcccg 2367181 gcggcttggt gaaaattcgt tcagcccgtc atcctgagcg agctttctgt atgtgtcagt 2367241 taataaaaca gcggcacagc ccacctttgc cccatgaaga atctgaggcc gttttttctc 2367301 cattaactcc atttcaatcc aatgtgaaat atgatgctcg ccgcctgatg ccggtcggga 2367361 atgatctaat gccagcatga caagccccga tacaagtaaa gactccatca aaacccgtat 2367421 gccagtttcc gttttcatcg caatgtcttc tgtgtgttca atgcaggcag caagcgcctc 2367481 ctgaacgatc ttagctcctg caggcgaata aggctcaccg gcaagatgcc gggatatttc 2367541 ccaatctgct aaagacgtga ttttaccgag catgtcacca aagccagccg ccaccattga 2367601 ctgcggtgcc gcttttaata gatccagatc agcgaacagc gcagatgggg ccttcgtttg 2367661 aatggttgtt ttcgtgccgt ataaaataat cggcgcaccg gctgatgtaa aaccgtctac 2367721 agatggagca gtcggataag aaataaacgg caaatctctt tgaaacgccg caaagcggac 2367781 gatatcatga atcgtgcccg aaccgactgc gatcatgaca tccgttggtt gtttcgtatg 2367841 gatcagcaca tgaatgagcg atcgttcatc agctgtcaca tctccggctt cattttctgg 2367901 aatgatcagg cactcggcct gaaatccttc ttgattcagt cggttttcta aatcaattcc 2367961 tgcaatgcgg tgtgtattcg cgtcgcagac aaggacaata tgttgattgt tttttcgttt 2368021 tacataatcc aaaagcgaat cagctgcttg cttaccgaga acaatttctt caacttttat 2368081 aggcaacgtc ttttctccgg cgttttcaaa agcacgctga acgtcagctg cgatacgatt 2368141 catatcagaa tcccctcctc agccaatttg gttacatcct taatagaatc cagcacataa 2368201 tccggcgtgt acaaacgctg ttcaccctgt ttcgcagaac cagttagcac taaggcgctt 2368261 ttcatgccat aaagcttccc catcgcaatg tcagattcaa tgctgtctcc tataatcatg 2368321 cattcatgtg cggacagccc cattgctgta caggcagcct ccgccatcag ccatgacggt 2368381 tttccgacaa caagttcagt cttcgcttgt gcagaagtct caattgcccc gatcattccg 2368441 gccacatcaa tggcatttcc gtcttcgttc ggaaaagagc ggtctttgtt tgtagcgata 2368501 atacgagcgc cgccggcagc cgcttgaaag gcttgattta aatcgtcgta cgtgagcgtt 2368561 tcatgaaggg agatcacgag ccaatccgct tccttcggtt cgctcgcgtt ctgcacaccg 2368621 gccagcctca gctcgtcaac caagccttgc tccccaagca cccatacctt tgaaaaacga 2368681 taatgttttt tcagaaaagc cgctgtcacg cttgatgaca gaacaatgtc gtttacgtcc 2368741 gtttcaatcc ccgcgccaag aagttttttt ctgcacatgg cacgggagat attcccccgg 2368801 ttgcttaaaa agacgatttt ctttcccatt ctcctaagcg ttttgatcgc ttctcttgct 2368861 ccttcgatca actcatttcc tctgaataca gtaccgtcca agtcaatcag aatgccagcc 2368921 ggtgacacag gcgtatcatg actggccata atacgcattt gctccgtgtt ttcgataaaa 2368981 atgcttttca tgcaggactg tattgattgg ggttacatcc ttgttcagca taatggagtg 2369041 ataggccatt tcggcaaccg tttctaatac aactgcgtta tgaatggcat ttaaggcgtc 2369101 agtgccccag cagaacggtc cgtgattatt cacgagcaca cccggcacct gttcgtaatt 2369161 atgatgctga aaggtttccg ctatgacttt tcctgtattc agttcgtagt catgaatgat 2369221 ttcttcatcg tacatttctc gagtacatgg aatcgcactg tcaaaataat cagcatgggt 2369281 cgtgcctaac ggagggatgt ctctgcccga ttgcgcccag cttgtcgccc attgagaatg 2369341 ggtatggaca attcccccga tattcggaaa ggctttatat agataaacat gggtaggtgt 2369401 atctgaagaa ggtttaagcg agccttcgac gacctctcca tcaaggttca aaacaaccaa 2369461 gtcatcggct gtcaggtcgc tgtattcgac tccgctaggt ttgatgacaa ttctttcttt 2369521 ttcacggtca atgccgctga catttcccca cgtaaaggtt accagctgat gctcttgaag 2369581 cttcaggttg gcagccagca cttctttttt taatgtttca agcatgctcc atcacccttt 2369641 atcaattctt tttggcggca gatgaaaatt gaagattttt gatcgttttc agacgcttca 2369701 tgacatggtt ttcttttccg aaataatgaa ccagctcttt atattcagcg tacaattttt 2369761 cataaaccgc ggcgttttcg gcatttggcg tataagttat atctttcagt tttcccatgt 2369821 tcgccgctgc ctttttgata tcatcgtagc cgcctttttc tttgcctgct gcaagcgcgc 2369881 cgaaaatggc agatcctaag gctggggctt gcggtgaacc agagatttta atgtccatgt 2369941 ttgtcacatc cgcataaatc tgcatgacaa acgggttttt ctcagctatt ccgccggctg 2370001 cgaacagttc ctcaatcgga acaccgcttt ctttgaatgt ttcgataatc atccgggttc 2370061 cgtaagctgt cgcttcaact aacgctctat aaatctcttc aggcttcgtc agcagtgtca 2370121 tgccaagcag catccctgtt aaatctgcat caacaagagt tgaacggttt ccattccacc 2370181 aatctaaagc aagcaagccg ctttcaccag gcgcttgatg gtttgctttc tcactcagca 2370241 gctcatgaac gccaatgttt ttttcctttg cttcctcttg ataagctggc gggacacatg 2370301 ttttcacaaa ccagtcaaaa tgatcgccga cacaggactg cccggcttca tatcccgcat 2370361 agcccgggag aattccgttg tccacaacgc cgcacattcc tggaacgata tgcacctctt 2370421 caccaagtag aacatggcac gtcgaggttc ccataatcat cagcattttc cctggctctg 2370481 taatgccgac cgccggtacc gaaacatgag cgtccacatt ggcaaccgca acagccgttc 2370541 ccgggagaag ccctgtcagc tttgccattt tttcagtcag actgccggct ttttctccta 2370601 ctgaatgaat agaacctgac aatttgtcct ttgtaatcgt tttcattgaa ggatttaatt 2370661 tctcaaagaa atcatctgac ggataccccg ctttttcact ccacatcgct ttataccctg 2370721 cggtacaatt gcttcgcttg agcgagccgc acagctggta cacgatccag tccgcagcct 2370781 cgatgatccg gtcagccgct tcataaatgt gaggcgcttc ctcggcaatt tgcatgacct 2370841 ttggaatcat ccattctgat gaaatttttc ctccgtaccg ctgtaaaaaa gcctctcctt 2370901 cttcttccgc gatttgattg agccgatcag catgtttttg ggccgcatga tgcttccaga 2370961 gcttcacata gctgtgcggc tcctcttcat attcaggcag catgcataac ggctgcccgc 2371021 tgctgtcaat aggaaggatc gtacatgccg tgaaatcaat tccaatcccg ataatgtctt 2371081 tcgggtcaac gcccgtctgt tcgagtaaag acggaatggt tgtttccaag acttcgaggt 2371141 aatcagcagg gtgctgcagc gcccagtcac gcggcagctt ttgacccgtt tttggaagga 2371201 cggtatcaat gacagcatgc ctgtattctt ttacagcagc cgcaagttcc tcccctgttt 2371261 ggacatgaac gagcactgct cttcctgata aagttccaaa atcaacccct attgtgtaag 2371321 ccatgtgaca tccccctcta cttttgaagc cggtaaagcg cctcgttcca ttttaactcg 2371381 tgtttcagtt tatgaattgt cgtatcacgg gaaatgagaa cactttcgat tcccgccatt 2371441 tccgcccaat caagcatttg ctccgctgtc agttcataag acaggcaggt atggtgtgca 2371501 ccgccggcta aaatccatgc ctccgctgct gttttcaatg acggctccgg cttccagaga 2371561 acacgggcaa ccggtaaatt cggcatgtct ttttcaattt cctggccgtt gacttcattc 2371621 agcacaaggc ggaaacgccc gccaatatca acaatgctag cttgaatggc agaaccgctg 2371681 atgccgttaa ataccaaacg cgcagggtcc tctttgccgc caatcgaaag cgaatgaacc 2371741 tcgattttcg gctgatccaa agcgacagtc ggacacactt caagcatgtg agagcccaga 2371801 atcatttcat ttcccggttc aaaatggtac gtgtaatctt ccatgaagga agttcttttt 2371861 cctttagcca tgattttcat catccgtaca agggccgctg tcttccaatc tccttcaccg 2371921 gcaaacccat agcctttctc catcaggcgc tgaacggcaa gtcccggcag ctgtttcatt 2371981 ccgtgcagca cttcaaacga tgtcgtaaac gctgtgtatc cgccttgctc aagaaaagcg 2372041 gttaatccaa gttcaatttt cgcctgttct ttaatggacg ctacctttgc ttcgtcacgt 2372101 tttgtttcct cactgatcac atatagtctg tcatactcgg cataaagcgt gtcaacctcg 2372161 tcgtccgtaa tgcgatccat cacttcaacg agatccccga tgccatatcc gtcaacctgc 2372221 cagccaaatt gaatatgcgc tcccaccttg tctccgtccg ttaccgcgac atgacgcatg 2372281 ttatctccaa atctggcaac cttaatatgt ctgctttcat ttaatgcagc cgccgtatcc 2372341 atccactggg acatttcttt tttcacttct tcatcatccc aatagccggc aatgactttt 2372401 cggctaagcc ccattctcga gttgatgtaa ccgtactctc gatcgccatg cgcggattgg 2372461 ttgctgttca taaaatccat gtcaatcgta ccccacggga tatcgcgatt atattgggta 2372521 tgcaaatgca taagcggttt ttgataagag gaaaggcctt ctatccacat ttttgcaggg 2372581 gaaaatgtgt gcatccatgt aatgatgcca gcacatgtct cactgtactc cgcttctctt 2372641 aacagctctc taatggtttc cggtgaagtg acgacgggct tatgagtgat tttatatctg 2372701 gaagaaatcc cgctgagccc ctcacaaatg cttttagcat gctgatctac gagttccagc 2372761 gtctcttccc cgtataggtg ctggcttcct gtcacaaacc agaattcata atcctttgtc 2372821 tgaagcatgt aaactgcccc tttctcataa aataaaacgc tttcaaatac aaaagatacg 2372881 tactaatgat agaaaataaa cctataaata aatatttgta cgaacaattt tattatagta 2372941 attgactatt atactgtcaa tcttttcttt taaaaaaagc cgggggcaga gcccggcttt 2373001 ttaattcaat aggacggcca gcccgagctc caattcaaat cattgatgag aagctttgga 2373061 atgccgttgt cattggcatc ataggcatgg cgaacaagaa tgtttccgtt cacaatatcc 2373121 tggcctccag gtcctttcca ttggtcattg cccgaatcca aaatggtgcc tccgccttca 2373181 agcatgcttt ttccgctttt atcaagataa gggcctgtaa tgcttttgga tcttccgtaa 2373241 gcaattttgt acgtactgtt taccccgtca cagcatttat caaatgaaac cattaaatag 2373301 taatatccat tttgatacgt aagagtagga gcttctaagg cacctccatt attcggtcta 2373361 gctgcaatcg aatagagcga gcctgtaggc ttcattgtac tcttatcgag cttagtcagc 2373421 ttaatgccgc tccaaaacga gccgaatgca agccacgggt tgccatcctt atcgaatgtc 2373481 agctccggat caatggcgtt ataattattt gagcttgtcg aacggatcac caagccctcg 2373541 tccttccagc cccccgaact gatgcttgtt gaagatgcca ggccaatggc agatgtattg 2373601 cttccaaaag aagaaacgga ataatatagc cagtacttgc cgttatagta ttggatgtcc 2373661 ggcgcccact ggttttggcc ataattcggc acataattgg accaccacga tagcggtgta 2373721 gtgaaaatgg atttttgtac ggtccaattt ttagcgtctg aagacttcaa aacccgcagt 2373781 ccccgttctt cagtaagccc tgttccgagc gcataccatg agctcccctc tttaatcata 2373841 gtcgggtcat gaagcagctc attggatgca ccccaaaacg ctgcctctgc gggagcagca 2373901 gaagtgaata tcaaacctgc agccagagct gcactcgaaa agtgtaagaa gcgtttccat 2373961 gtttttttct ttttcaattt tgttcaacct cctttatttt agaaagcgct tacaaattag 2374021 attatttatc ctcccttcct gtcaaatcga ctgcgtatcg tatatcgtca tgttcaggaa 2374081 attttcggta tcccctttat tgtagtcact atgctgtaat ttgtacagac aaaaaaatag 2374141 aatccacctc aataggcgga ttcttccgta tctttattgg tacgtaattt cgtcaaccgt 2374201 ttttcggtct aacttcttaa tgacttctgt aattaacttt accgcgtttt cataatcatc 2374261 acgatgcagc atggccgcgt gcgtatgaat gtagcgggtt gcaatggtaa tggacagcgc 2374321 aggaacgcca tttgccgtca aatggatggc acccgaatca gttccgccgc cggcaatggc 2374381 atcaaattgg tacggaatgc cggcttcctc cgcagtggct acaactgcat cgcgcaaacc 2374441 tttgtgagag accatggatg catcgtaaac gataatctgc gggcctttgc ccattttgct 2374501 ctgcgcttcc ttctcggaaa tgccaggcgt gtctcctgct atccctacat caacaccaaa 2374561 cgcaatatca ggctgaatgg tgtgtgcagc cgttttcgct cccctcagcc cgacttcctc 2374621 ctgcacggtt ccgacgccat acactatatt tggatgatct gtgttttgta agtttcttaa 2374681 cacatcaata gcaatcgcac agccgatgcg gttgtcccag gcctttgcga gtaggaattt 2374741 ttcattgttc atgaccgtaa attcaaaatg cggaacgatc atatctcccg gaagtacacc 2374801 ccactccaag gcttcttccc ggcttgaagc tccaatatca ataaacatgt cttttatttc 2374861 cactgatttt tttcttgctt caggagacaa aatatgaggc ggcttagatc cgataacccc 2374921 tgtgatttct cctttttttg tgacaatggt gacgcgctga gcaagcataa cctgagccca 2374981 ccagccgcca acggtttgaa aacggataaa gcctttatct gtgatttgtg tcaccataaa 2375041 gccgacttca tccaaatgtc cggcgatcat aattttcggg ccgttttctg caccagtttt 2375101 ttttgcaatt aaactgccca ggcgatctgt tgtcacctca tcagcaaatg gttctatgta 2375161 tgatttcatc acttgcctta cttctctttc attgcccggt atgccttttg catctgttaa 2375221 atctttcagc atggtcaatg tttcatctaa ttttgccatg ttccaaaccc tccttcatca 2375281 gtcctgcatt cttattatac aaaacatggc gctaaccata cgactatttc acttgaaaat 2375341 cgggtatatg tttttacagc tttcttttag aaaaagtgaa acctttttct atgcttttcg 2375401 tattacatca gatcatcacc ataagggagg tgccttcaca caatgtttgt catggttcta 2375461 aggattattt tgcttgcact ttttgcttat tgtatttatg ccgtggtcaa atatgtcgcg 2375521 aatcctaaga gaaggcttaa gctggcccaa tcaaaagaac atttttatat tattgatgaa 2375581 caaaacaata cccggaagaa ttttcagctg acgtataaag gcgtgctttt tgagggagaa 2375641 aagcatattc cttccaagga tcatccgctg tttattcaca cgatctttgt ctggacagaa 2375701 tctcctgaga agctgaaaca tttctctgca aaagattttg agaacattga agaaaaagtg 2375761 ctggaacgat atccaaattg taagattgac tgggaccagc ccattaaact cgcaaaaaaa 2375821 gcagaagagc gttaaacgct tttctgcttt ttataaatca aacgggctgt agtaaatagc 2375881 gatgagaatc gcttctatta ccagaagaag cggtactccg tacttaaaag aagcgtgttt 2375941 cgttttatgt ctgaaggttt gcatgccaag ccagacaccg agcgctccaa acacgatggc 2376001 tatcagccac agccggtctt cagaaattct ccacttgtgc tgctgcgctt tgcgtttgtc 2376061 aatgcccatc acccaaaaac cgcacagatt aatcaacacc aaataagcag caataatcat 2376121 gttgcctcat cctttatata gaaaaagccg ctctgctgga gagcggctct atatgattac 2376181 ttgtttaatt gagctttagc agcatcagca agctgattga atgcagtaag atcgtttaca 2376241 gcaagatcag caagcatttt acggtttact tcgataccag aaagcttaag accgtgcatt 2376301 aaacggctgt aagaaaggcc gttcatgcga gcagctgcgt tgatacgagt gatccaaagt 2376361 ttacggaaat cacgtttttt ctgacgacgg tcacggaaag catagtttcc agatttcatg 2376421 acctgctggt tagctacttt gtataatgta tgttttgaac cgaaataacc ttttgctaat 2376481 ttaagaacct ttttacgacg cttacgtgta acagttccgc cttttactct tggcattgaa 2376541 tttccctcct aattgttcct tatccgatta cttgatgtta gcaagcattt gtttgatacg 2376601 tttgaagtct cctgcgctta caacagcact cttgcgaagc ttacgctttt gcttttgaga 2376661 tttgttggcg aataagtgac ttgtgtacgc gtgagaacgt tttaacttcc cagaacctgt 2376721 ctttttaaaa cgtttagcag atccgcggtg agttttcatt tttggcatgg gatttcctcc 2376781 ttattgcttt tcgtttttcg gtgcgagcat taagaacatg ctgcggccgt ccatttttgg 2376841 ttttgtttcg actgtcgcaa cctcagcaca tgcttcggag aaacggtcta atacacgctg 2376901 accgatttct ttatgagtga ttgcgcgtcc tttaaagcgg atagaagctt tcactttatc 2376961 gcctttttca aggaatttaa tcgcattgcg caatttcgtg ttaaagtcat gctcatcgat 2377021 tgtcggactt aaccgaactt cttttaagtt aatgattttt tgattcttgc gtgcttcttt 2377081 ttcctttttc tgctgctcaa atcggaactt accgtagtcc atgattcggc agacaggcgg 2377141 ttttgcattc gctgcaacta acacaaggtc aagatttgcg cggccggcga tttcaagtgc 2377201 ttcctgacgg gacttgattc caagctggtc gccattttgt ccgattaaac ggacctcacg 2377261 tgcacggata ccctcattaa ccaattgatc tttgctaata atgagccacc tccatagttt 2377321 cttcgaattg attcacaact cattttgaat gcattttgca ggcaaacaaa aagtgtgggc 2377381 attataaaac acccacacta cgaacatctg tatcaataaa aatgtacggt caacctgcca 2377441 actacatgca tgtgtcaatc aggtgagaag cgggtgcttc tgcttgtgat ttatattcaa 2377501 ttcaataact attctacaca ataccggatc tttagtcaag gacgacttat ccggaacaac 2377561 ttttacattg taacatgggt tttctatgag cgcaagagag aaaaagaaaa tctttcatcc 2377621 ccacccagaa tacaaagaac caacaattcc cccttattac gcaatttaca acaaaaccac 2377681 cgacaggaag aaatgtaaaa caaagttaat ctctgaccga tataaggagc agaagggagc 2377741 ctgacacatg aacaaactga tacagcttgc tttatttttc acattgatgt taaccggttg 2377801 ctcgaatagc agcacatctt ccgaatcaaa agtcgaaacc actgttaaga caacggcagc 2377861 atttcctcaa aaggagctgg agaaagagct aaaaaaacta aaacccgttt cattggacat 2377921 gaagttcgag agtccactcg ctaccgagtt aggaaagcgg aaggcaaaag aggaagctga 2377981 aaagcaaaga caaatcgccg ctgagaaaaa gcttgaaaaa gagcgggagg cgaaacgaaa 2378041 gaaacagcag gaggaaaaag cggagagaca gcgattagca gagcagcagg ctgcagagag 2378101 acagcgatta gccgaagcgg aaagacaagc tgaacttgaa agacagcggc aggcagcaat 2378161 ccaaaaagag cagaaagcga acgctgagaa aaagcggcaa tcgcaggcac aacggcagca 2378221 gactgaggca ccctcatcta atagtcaaga tccaccatct tcctcgagtc agacagataa 2378281 aaccattcaa cagccagctt cagagcttcc tgatgacgat ggttatggtt atgaagaacg 2378341 aaaaaagtgg catgacgatc aagtagaatg gggcattaaa caagggtata tcgatcccga 2378401 agacgcacca taaaataaaa aaagccaagg cattcagcct tggcttatcc tccgatcagc 2378461 tgcacgaaca cagggatgac cagaaccgtt accactccta ctacgacaac agcaatactt 2378521 gccatcgcag cttcaacttc tcccatctca atcccgaccg ctacaccaag tgcatgtccg 2378581 gatgttccaa gagccaatcc tttagaaatc ggatttttca ctttaaacac cttcaagaac 2378641 aatgctccga gcgcatatac gatgacagcg ttaaagatga ccgcaaaggc tgtgatgtcg 2378701 ctgatgcccc cgatgccttt tgataaagga agcgcaattg ccgttgtagc cgcctgcgga 2378761 agcatgcttt tcattacggc cgaatcgaga tgaatgcctt tagcgagcag ataaacaatc 2378821 gtgacagagc agatagagcc ggcaataatg gaggccatga tttgccacca gtacttttta 2378881 agcttatctc tttgtttgta caaaggaatt gcaaatgcga tcgttgccgg ttcaagaaaa 2378941 aacttaatga tctctccccc gttattataa tccgcgtagg aaaaaccgcc gatttttaaa 2379001 aatgcgatcc ccagcaccat ggcaacaaac aaaggagtga aaaggaagaa gcctttcgtt 2379061 ttcttaaata aaaaggtgcc gatgccgaat gcagcaagtg atacgacaat cccaaaataa 2379121 ggactcattg tgctttccat gtgaagaacc tcctgtttcc cttaatggtg aacgagttcg 2379181 ttattgttct gcgggctttg cactgttttt gttttcatgt ccgcttcggt tttgcgtttt 2379241 ccgctcagcg acagaatcag ctgagaaaac aatcccgtag cccccagcaa aataatcgtt 2379301 gcgagcagaa tgacaagaac aatttgcagg ccgtattgct gcatcacacc aagcgaattc 2379361 ataacagata tacctgatgg aacaaataaa aatccgatca gagaggttaa agacgttccg 2379421 agcgtctcca cttgttccag tttaatgact ttcaaacata ataggagaaa taataagacc 2379481 aaccctacaa ccgatgccgg gataggtatt gggacaatag cggcaatcat atttgaaacc 2379541 agcataatga cggcaaaaat aaatgcttgt gttaaaaacc cgtacacttt tttagcactc 2379601 attttcttca cctctttctc tttggtaccc tcattataaa taagaattcc ctgttataaa 2379661 gcgcttacaa gataacatgc cgtatagcgg gtctgagttg cagaatcaaa tggctgaaat 2379721 gcaaaaagcc gcccatcaaa tatggagcag ctttttcaat tccttcgcat atgtccggct 2379781 gaccggtatt ttcgatccgt ctttcatgat cagattatac gttgaattaa accatggctg 2379841 aatttcttta atatattcag tattcacgac aaagctccga tggacgcgga taaaatcaga 2379901 atccggcagc tttttctcaa tcacaacgag tgtatcgctg accgtataag aatgatcgaa 2379961 ggtttttaca ttgacatgac catcttctgt tccggcatag ataatgtcct tcgtatccac 2380021 aatcacaatc gattccccca cagatagcgc gagcttgtgc tggccggcat ggctgttttg 2380081 ctctgtttct acaatatccc gattgacttt tttatatttt ttcagcgttt gctgaattct 2380141 ttcttcatcg aaaggcttgg ttaaataatc aagagcgtcc acctcaaacg ctttgagcgc 2380201 atactggtca tacgctgtcg caaacacaat agcaggagga tgcttcattt tcttcaatcg 2380261 ctttgcgata tcaaaaccgt tttctccgga taaatcaacg tctaaaaaca gcaaatcagg 2380321 tttttgatcc atcatttggt caaaagcgga ttcgatattt tccgcttcat tgatttccat 2380381 ttcatcattg gtccgcttaa gcaagtaagc cagttcatcc cttgccagca tctcatcatc 2380441 aactattaac accctgagca tgttcttctc cctctttcat ctgttgcatt ggcacttgaa 2380501 aggaaacctc tgtcccttta tgaacctcac tgctgatatg cagtgcagcc tgctgtccga 2380561 ataaaccgat cagccgctga tttaggttat aaagcgctgt accggttccc tccttagacg 2380621 gaaacggttt cttccccagt tccggcaaga cgtccggcgg aattccgcgt ccgttatccg 2380681 ccaccttcat atagacggat gcatcatcag ataagacaca gactgtaacc ttgcatatgt 2380741 cttgtttttt cggaaacgcg tgccgaagcg cgttctcgac aagcacctgc aaaacaaacg 2380801 gagggatttc aatctgctcc agtctgctgt cgatattaag ctcaatttta tatttcccgg 2380861 gaaaacgcgc ctgttctaat gacaaatagg cgttaagatg gttcagctcc tttgagagcg 2380921 gaatcagcag ctgtctcgct ccttgaaggt ttgaacgaaa ataaacactg agctgcaata 2380981 ggagcttacg ggttttttca acatctgtac ggcataacgc agaaatcgtg ttgatcgcat 2381041 taaataaaaa atgcggattc acctgtgctt gaagcgcttt aatttcagca tccttgagaa 2381101 gtttgctttg cagctctgct tccccaagct caagctgtgt cgaaaacagc atggccagcc 2381161 cctcggcaag ttcctcctct acctgactca ggcctgccgg gcttttaaag tacattttta 2381221 aggtgccgat tgtattgccg ttcgatgtca gcggtaggac aattgcagcg tgcaaagggc 2381281 attcagcatg cgtgcattca atctcttcct gcgaaatcgc cttcataata tgccctgttt 2381341 taatcacctt tttggacagg ccggtgatca agcttttcga tgggatgtgg tgatccattc 2381401 ccgcaccgac atgcgcaagg atcttttctt tgtcagtgag agacaccgca tctgttcctg 2381461 tcagcttatg gataatagcc gctacacttt tacaggagtt ttcatttaat ccttggcgga 2381521 aaaatggaag tgtctgatca gcaatcgtaa gcactcgatg cgtttcgaga gcccttgcct 2381581 gttcttcctt gcgaatgatc gcttgaataa tagacagaaa aataaaactg cctgttccat 2381641 tgatgagtat catcggaatt ccgatcatgc tgacaagctc ccaagcgtca ctgaacggct 2381701 ttgccatcag caaaataatg atcatttgca gtgactccat gccgattccc acaagagcgg 2381761 cgatgcgcgg tgtcggcatt cgatatcgct tcgtaaaata cctgccgatc aagcctgcaa 2381821 gaacacccgc taaaatagat gagacggcac agcttaaggc cgtgctgcca ccgagtgaaa 2381881 aacgatgcag gcccgcaagt atgccgatcc cagcccctac aaaaggacct ccgagaaggc 2381941 ccccgatttc cacgcccaaa atacgggtat tcgcgataga gcccgatgga tctatcgtaa 2382001 acacccagtc attgtttaca atcatatttc tttgaatttc gatgcctgta taattgctga 2382061 tgatgctgaa aagagaaaaa atagaaatta aaatcgcttt tcctttatag ccgtcctgat 2382121 tctgaagagc ttgtctgaaa agtttcgtat gggcgagaat gaaccctaat ataacaataa 2382181 tccccactct ctccagcatc ataatcatta aatgaatcat tcatgtcacc tgttctttcc 2382241 gttttcattc tagcatgttt tcgttttgcg gctgactgtt tttttaaaat cgtctgaaaa 2382301 catatttcac aaggctttta tctattgtaa aataaaacat gagccttttg gcagaaagat 2382361 ttgaatctga agcagaggag aagatcatga aagccgtatt ttttgattta gatgatacac 2382421 tactttggga cgaaaaaagc gtcagaacaa catttgcaga aacttgctta caggcggaga 2382481 aaaaatatgg ccttgcccct gaggaattcg aagcagctgt tcgcgaagcg gcgagagaat 2382541 tgtacatgtc atatgagacg tatccatata cagtgatgat cggcattaac ccgtttgaag 2382601 gactgtggtc caatttctca gagccaatca gtgaaggctt tcaaaagctg aacaagattg 2382661 tgccggagta cagaagaaat gcatggacca acggactgaa agcgcttggg atcgatgatc 2382721 ctgcatatgg cgaatacttg ggagagtttt ttgcggcaga gcgcagaaag cgcccgtttg 2382781 tatatgatga aacttttgct gtactcgatc aattaaaagg caagtatgaa ttattgcttt 2382841 tgacaaatgg cgatcctagt ctgcaaaagg agaagcttgc cggcgtgcct gagctcgctc 2382901 cttacttcaa tgaaatcgtc atctcgggcg cattcggcaa gggcaagccg gatgtttcaa 2382961 tttttgaaca ctgccttaag ctgatgaata ttgaaaaaga cgatgccatc atggtcggcg 2383021 ataatttgaa tactgatatt ttaggcgctt caagagccgg aatcaaaacc gtttggatca 2383081 accggactga taagaaaaac gaaactgacg taaagcctga ttacatcatc agcagccttc 2383141 atgatttgtt tcctatatta gagaaataaa aaaagcatga tctcttcaat gagatcatgc 2383201 ttttttattt tattttttcg cttcagctac tgcctttttc acaaactcat caagtgaaat 2383261 ggtttcagag ttctgttctc cgtatttacg cacgtttacc gctccgtttt ctgcttcttg 2383321 gtcaccgacc accagcatgt acgggatttt ttgcatttgc gcttcacgga ttttgtagcc 2383381 gattttttca tcgcggctgt cgacttcaac acgcaggcct tcacattgca ggcgttcctg 2383441 cacttttttc gcgtagtcta aatgcacagc cggagaaacc gggatgactt ggaactgaac 2383501 cggtgcaagc catgtcggca gcgcgccttt gtgttcttcg attaagaaag caacaaagcg 2383561 ttccattgtt gaaacgacac ctctgtgaat gacaaccgga cggtgctgct tgccgtcctc 2383621 accgatgtat gtcaggtcga aacgttccgg caataagaaa tcaagctgaa ccgtagacag 2383681 tgtttcttct tttccgatcg cagttttcac ctgaacatca agtttaggtc cgtagaatgc 2383741 cgcttcacct tctgcttcgt aatagtcgtg gccgatttca tccattgcct ctttcagcat 2383801 ggattgcgct ttgttccaca tttcatcgtc atcaaaatat ttctctgtat cttccggatc 2383861 gcggtaagac agacggaatg tgtaatcact taaaccgaag tcttcataaa catcctggat 2383921 taaacggact gtacggataa actcatcctt aatttgatcc gggcgcacaa agatgtgtgc 2383981 atcatttaac gtcattccgc gtacccgttg aagtcctgac agcgcacctg acatttcata 2384041 gcggtgcatc gttccaagct ctgcaatacg aatcggaagc tcgcggtaac tgtgaatgtc 2384101 ttgtttgtaa atcatcatat ggtgcggaca gttcatcgga cgcaatacaa gtgtttcatt 2384161 gtccatttcc atcggaggga acatgccttc ctgataatga tcccagtgtc ctgatgtttc 2384221 atacagctct ttgctgccta gcacaggtgt gtatacgtgc tcatagccga ggctgatttc 2384281 tttatcgaca atgtagcgct cgatgacgcg gcggattgtt gcgccttttg gcagccaaag 2384341 cggcaggcct tgtccgactt tttgagagtt cgcgaacagc tttaattctt tgccaagctt 2384401 tctgtggtcg cgttctttcg cttcttctag catacgaaga tgctcttcaa gatcagcttt 2384461 tttgaagaaa gctgtaccat atacgcgctg aagcatttgg tttttgctgt caccgcgcca 2384521 gtatgcgcct gcaaggctta acagcttaaa ttctttgatt tttccggttg aaggaacatg 2384581 gacgccgcgg cacaggtcaa agaattcgcc ttgctcatag atcgaaacgg tttctccttc 2384641 aggaatcgca tccaatagtt caagcttcag gtcgtcgccg atttccgcaa aacgggcttt 2384701 cgcttcttca cggctgactt cttttcgaac gatcggaagg ttcgcattaa cgattttttt 2384761 catttctttc tcgattttcg gcagatcctc cggtgtaatc gcttcgtcca tttctacatc 2384821 gtagtaaaaa ccgttttcga taaccggacc gacgccgaat ttaacatcct tgtagatgcg 2384881 tttaatcgct tgagccagca agtgagccgc actgtggcgc ataatttgaa gaccttcttc 2384941 tgagccttct gtaatgattt ccactgtacc gtcttcattg atcggcgttc tcaaatcgat 2385001 ttcttttccg ttcagttttc cggctaatga ctttttcttt aatcccggac tgatggatgc 2385061 cgcgatatct tctgttgttg ttcctttcgc aaactccttg actgctccat caggaaatgt 2385121 gatttttacc atatctgaca tctttgtcac tccttttttt gcatataaaa accccgcccc 2385181 ctatgaaagg gacgaggttg aataaacgga atcgtggttc cacccttttt tccgcaaagc 2385241 caatacacgg cacctgcggc tctaagctct gtaacgggag ttcccgtcag ccattactgt 2385301 tccttttcaa gaggttcaca gctgaagttc aaaggcggta aagcgaatgg tccttagctg 2385361 ggaagcttgc agccagggct tccctctctt tgagccggta tcattccttc gtgtccttat 2385421 caatacgtgt gtctttctta atctcctatg tattataaat tgttcaatcc aaaaaatcaa 2385481 cacgatcgcg tttccttttt tttaaaccga cagccttaaa tagacaggct gccggccctc 2385541 atccttccga gtgcttcacc ggtatttctg catctgtaaa agcatgcagc gggagcattt 2385601 ccactctctc ttgaaatacg ttttgaatgg tccttgccat catgtgctcg ggctggtcgg 2385661 tataaagcac gacttcatca ggcgcaatgg aaatcagcgg cgcgagcaaa tgagaatcaa 2385721 tatacatagg atgatcccgg acaaatcttc tgtctatgta tttcattttt tcccgttccg 2385781 gcacatagcg cagctcccat aatgtaaagg aaccatcatg gacaatatgc acttttttga 2385841 ttcgcggctg tttggcgtcc acatagtctc tgagtgtttg aataaagttt tgatattcct 2385901 gttccatctt atattcatca atcgctgctt ctgtaatatc tctcagctgc ttatagtatg 2385961 atccaagtcg gaaggtctga aaggagcgaa tgtaaaatac tccttcctct aaacagatcg 2386021 tttggagttc atccaaaatt gattgtttcc gtgaaagctt cagcggctca aacggaagat 2386081 cgtctgcttc accttcaata atactgtgtg cgagctgaag gatttgctgc tgttcatcct 2386141 ggtccgtgaa acaatacgtt tcctcaatca atgacagcat atgctcgtct tctttgcatt 2386201 ccaaaaaaaa tttgaccaga atcggctcca taaaacgctg aataggaaaa gccggattcg 2386261 ctttttcaat cccgattttt cgtatgcctt cacggacaat gatattgttc cgatcgtccg 2386321 aatgctgaat gagatgtaaa aaagcggctg catcatggtc atcttcaaag attatttcaa 2386381 gcatgtttgt ccccccttac ggcatctgtt acaagtatat gggggatgtt tttaaaatag 2386441 acgtaaaggt cattggcaaa tcttaatttg attcttggaa caagttttgc attttctttc 2386501 tgaagatgaa cggcaatgag ataaacacga tatacaaagc gagcaccata aagaaagcgg 2386561 gcagattgcc agccaaaaag ctcgcaccca gcacattaag cgcaatcgtc ccagggatga 2386621 ttcccacagc cgttgcggca aaatacggca gcgctttgac attggaaagg cctgccgcat 2386681 agctgacgaa atcaaaattg atcggcagga ttctcaaaag aaagatatag aaaaatccgt 2386741 tatcctccat ttgcttctgt atggcttcaa gcctttcgta atgcccgttc tttttcgccg 2386801 aaaacaaacc agccgcaaaa aacgaaacag ctgaagcgca catcgaaccg aataacgtat 2386861 aaagcgtgcc gagaagcggg ccaaacgcaa gtccgccagc tattgaaata acagacaccg 2386921 gaaataaaac aagtggcctg acgatggata tcccgataaa catcagaggt gcaaagactc 2386981 cgaacgacaa tacccatacc ctgatttctt tcggcgatac attcaaatac gttttatttc 2387041 cccaatagag taaaccagca cctgcaagca ctgccagcca tttgacagcc gtttttcgtt 2387101 tcataccctc agttccttcc cctttgaacc acagcaatta tggatgtcgg cggttttctc 2387161 cgtcaaggcg gatcggagca gccaaatata atatccgctc cattaatctt gcagctttta 2387221 cttcttcttt ttctcccctc tgcgaatacg taaaatgatg cttcagctcg tcaggtgaga 2387281 aattagaaga aaagaacgtt ggcagctgct gggacattct gtgctgaagc accgttccga 2387341 tgacctcatc ccttacccag cttgtcattg attctgctcc gatgtcatca agcattaata 2387401 cgggtgtggt ctttaccata ttgagcttct cttccaatgt ctggtcttgc agcgaattct 2387461 taagctctct cacaaattca ggcacataaa caatcatgga ggaatactct ttttccgcca 2387521 gctcattggc aattgcagcg agcataaacg tttttcctac cccaaatttc ccgtataaat 2387581 ataatccttt cccttttccc gtctcattat agcttttcag gaagtctgta acatgctgaa 2387641 acatcgcgag tctgcttggg tcactgatat caacttgctg gaacgtcgct ccaagaagat 2387701 cctgctggat atacatgctt ttcataagag actgttgttt cttctgctgg tcgagcttcc 2387761 gtttgactgg acattcgtaa tactcgatat caatagacct cccattgaca acaagcttcg 2387821 gatggtagcc ctccaacaaa ttgttgcagt tttcatcttc cgaacaatag gagcaattct 2387881 tgctttgttc gatatattca taaagcttat ttaagctctt ttcgatcatt ttttggtcaa 2387941 tcacttcttc gttttccttc aaaaatgctt gaacatcttg atctttcatg actttttcct 2388001 tcatttgttc aagacgtttt tggaaatccg gcctgccggt tacgccctgc agggaacggc 2388061 cgattggttc catctattcc ttcaccccgc atctctgtct ttaataggca gagtattttt 2388121 tcagtttttg catttcttcc atcatctttt tcttctgttc ttccaaatcc tgcggatgca 2388181 gcttctgctg tccggattct gaatcggacg ctgtttcctt ttctgtcatc caatcaggaa 2388241 gcttttcttc acgaatcact ttttggtttc gtttcgaaga ctttgttttt ccctcagccc 2388301 attcaagata ctggcggttt tcttctattg cgagcttcat cgcttccctg accgttttca 2388361 cctttttgcg tgcccaatgc gaagcgattt tttggatata gtttttcgac agcttcatgt 2388421 cggttttcag catgacataa taaattaaca catttgtgac gcctggctcg agcttctgtt 2388481 cgaacataat ttcttctatg atcttcagat cagcttttga cggctctgtt ccgtcagcaa 2388541 tgtcctgcag aagcttcttc ggggaaatcg cctccagcaa tgcaatcagc ttcccatcca 2388601 gagaatcctc ttctgccggt tgttcgcctt cacgcagatg caccggctgt gttttttcca 2388661 ccaaatcggg cagctgtccg tttctttcaa tttgatacca gtcgctcgcc gcttttctta 2388721 atgcctccgt cgtaatgacg tcacgctcat caattgcgct catcacaaca ttttgcattt 2388781 gcaaagggtc aattccgtac agataagaaa gctttttgat tgtgtcccgc acctgctggg 2388841 tcatcgcttt tctcggtatc atcgtctcag aaagtcccgc taaaaacaaa tcaaaatcaa 2388901 acacatcctc cgttatggtg taggacggag actgtccgac agaagtatac tcggacccct 2388961 cggcaagcct taccgtttcc tccatatcgg atgtgagctt ccattcactc ggctgcagcg 2389021 attcaaacgc atgattaaac ggacgcgtaa tgtccttcgc atcttctgaa atggccgggt 2389081 gcgtaaaaaa ttgttttaat tgctgatatt tcgtttttcc gaccctatta tacagaaaaa 2389141 cattcagcat tccgtcttca aaaaattcat ttggtctgag cggcggaagg agttcatata 2389201 taaagaggcg ctcctgccgc tcggattctt tcatatatac tttcagcaat ccgatgccct 2389261 cgagcttccc ctgttcctga tggatcgttt ttaagttgga ctgtgtcatc cccatcagct 2389321 gtctatgtgt ggactctccg ccccacagac ggttttgttc aagctctccc cacaatgtca 2389381 tataaagaga gaatgcaaca gggccgatta agggctggta cagttgtgta ataatttgtc 2389441 tgtcaatatc ctgcagcatc gatctgcttt taaccacata cgggtctaca ggcagtacat 2389501 ctttccaata gtcagccata cattctcaaa ccttccgaat ttgtttctac ctttcatttt 2389561 acaccgtttc ttatatctat caaatgccaa ttttgcacat gagaaaagag ctagaagaat 2389621 cctcttagct cttttaacgc tctttcttta ttaagtcttt taattcatcg ataaagacgt 2389681 ttatatcttt aaactgccga tagacggacg cgaaccgcac atatgcgact tcgtcaatct 2389741 tagccagccg gtccatgacc atttctccga cgagctcact cttcacctcg gagcagcctt 2389801 gattgcgaag ttctttttca atatcaaagc acatgtcttc aagcgttttg agtgaaacag 2389861 gccttttttc acatgctttt atgaggccgc gcagcatttt ttctctgctg aattcctcac 2389921 gcacaccttc ttttttcaca acgatgagcg gggtttcctc cactttctca aaggtcgtaa 2389981 accggtagtg gcaggattcg cactcgcgtc ttcggcgaat cgactttccg tcatccacag 2390041 gccgtgaatc aaggactcgt gttccgttat gctggcatga aggacatttc aataaaatca 2390101 gctcccaact atatcgttcc ctgcaatgta ttttcggcag cctccgcctt ttaaaaatag 2390161 atgtgacagc atctgtcggg agagccgttg ttaaatttgt ttctatagca ttaggtggtt 2390221 tgtgaaaatc tccttcttat tttacaaaaa aaatgaaaaa agaaaaagct gacactctcg 2390281 tttctttata aaaataaaag gagcataagc taaaaagcgc ataatggctt tctagcttca 2390341 gctccctttg tgttcgcaat ttactttata gtactttcgc ttgcgcctgt ttaatttgca 2390401 caggccccat tcctcttggt atttcaatgt tttctcttgt atcagcatgt aatgcctctg 2390461 caatgtaatc agcagcgaca ttaggatcta agtctccaca agtataaaca tcaatgctcg 2390521 catatccgtg ctcaggaaaa ctgtgaatcg ttaagtgtga ttcagaaata atcacaactc 2390581 cgcttacgcc ttgcggtgca aatttgtgaa atgcaacctc gcgcacctca gcacctgatt 2390641 ttagagcagc atttacaaac gttttttcaa taaaatccat gtcattcagc ttatcaaaat 2390701 cgcatcccca tagctcggag ataacgtgac gccccattgt ttccatagtc atggaccccc 2390761 cttaacaaga attaaaaagt gaaattccaa caactgggtc ggccatttac cacgggggaa 2390821 agttagtccg gagaggtcct aaccctttaa gtaattccga aacagtctca agcaagaagt 2390881 tcacgaaaaa tagtatactg tgtttaagtc taatttgcaa ggtgcgtttt ttcagaaata 2390941 tgctgttaag ggttttttct ttaaaatgtg tccatgacct tattttatac agcagacgga 2391001 tgtttcattc gtgccgctac atggcggatt agatcaacaa ctctgcagga gtagccccat 2391061 tcgttgtcat accacgccag cacctttact ttcctgtctt ccattaccat tgttgtaagc 2391121 ccgtcaatga ccgctgaatg cggattcgta ttataatcag tcgaaacgag cggttcatct 2391181 gagtaatcaa gtacaccgta catcgacgtt ttggcagcgc gtttaaatgc ctcgtttact 2391241 tcttcagccg taacatccgt tttcagatca acaacgagat caaccaatga gacgttcgga 2391301 acagggacac gcaaggcgag gccgtgaagt tttcctttca gatgcggcag cacaagcgaa 2391361 agcgcctttg ccgctcctgt tgttgttgga atgatggatt caccgcaagc ccgcgcccgg 2391421 cgcaaatctt tgtgcgggtt atcaatattt ttttggtcat tcgtatacgc atgaactgta 2391481 gtcatcagac cgctctcaat gccaaactct tcatccagca cttttacaac aggcgcaagg 2391541 caatttgtcg tgcatgacgc atttgaaata atgacatggc gctcagcgtc gaattggtcc 2391601 tcatttacgc ccatcacaat ggtaacgtct tcattttttc ccggagcggt caaaatcact 2391661 ttttttgcac ctgcttctat atggcccatc gctttatctt tagcattaaa cttccctgtt 2391721 gcttcgacga ctatgtcaat atcatattcc cgccaaggca gctgttttgg atcacggctg 2391781 tttaacaaaa gcactttctt tccatttacg atcaggctat cttcaccagc cacaacctct 2391841 ttgtcgtatc tgccgtgaat tgtgtcatac tttattaaat gagccagcgt ttctgcggaa 2391901 tagctggcgt taatggccac tacttgaatt tgatcgtcta acatcgcttt tctaaaaacc 2391961 attcttccga ttcttccaaa cccgttgatc gctactttta ccttcatgtt ggacacccct 2392021 tatcaattat gccatcctaa tttgttacta tctaaaatta gtataacaca ttaaaacaaa 2392081 ttcgccagta catattgata aaaatcaacg attataacgc taatttatga tgcatcttat 2392141 gttttcttgc acagaatatc aggcgtaaga accaaaaagc agccagcgct ccgcactgac 2392201 tgccctcatg ctttatgatt cctgttttaa cttatcattg agcacacttt cttctagcac 2392261 agaaaatgta tccccgtaca ctctgttaat atgattcgct ccccaagcac acagcatatc 2392321 taaaatccct tctaagctgc ggccgtattc gctgagctcg tattccactt tgggaggaac 2392381 ttgattatat acgattcggt taatgacacc gtccgcttcc agctcgcgca gctgctgagt 2392441 cagcattttt tgcgtgatat tgggcattag gcgttttaat tcacttgtgc gtttttttcc 2392501 gtgcgtcaga tggcataaaa tgacgcattt ccatttccca ccgatcactt caagagtcgc 2392561 ttcaacagaa atgttatatt ttttcttctc catacaatcc attctcctca caggcaccaa 2392621 aaagtgacta tagcacttca aagtacgtac ttttatttct taacgatatg tttcataatc 2392681 acatttgccg gctgatttga atctgctctt ttttatttat atagcttact cggcagaatt 2392741 tcaatcatac aacacatctt acaaaggagg aacatcatga cttcagccaa taaaagcaat 2392801 attcctgcac tactggcttt ggccgtaagt gcattcgcaa tagggacaac tgaatttatc 2392861 agtgtcggcc ttttgccgct cattgctgat gacctggata ttcccgtcac gacagcagga 2392921 ttgaccgttt ccctttatgc gctcggcgtt acatttgggg cacctatatt aacttcattg 2392981 acctcaagca tgtcacgtaa gacactattg ctttggatca tgtttatttt tattgccggt 2393041 aatacgatgg cagcaaccgc ttcaagcatc gggattttac tagcagcacg tgtgatatcg 2393101 gcattttcgc acggtgtgtt tatgtcgatc ggttcgacaa tcgcagcgga tattgtcccg 2393161 gaggataaaa gggctagcgc gatttcaatt atgtttactg gcctcactgt ggcaactgta 2393221 accggagttc cttttgggac atttatcggc cagcagttcg gctggcgttt cgcctttatg 2393281 gtcattatcg ccgtcggaat cattgctttc attacaaatg gcattcttgt accgtccaaa 2393341 ttacgaaaag ggacgaaaac aacgatgcgg gatcaattga agcttgtgac aaacagccgg 2393401 ttattgcttt tatttgtcat tacagcgctt ggatacggag gaacattcgt tgtgttcacg 2393461 tatctgtctc ccctgcttca ggaagtaaca ggcttcaaag ccgggactgt tgcagtgatt 2393521 ctgctcggat acggaatagc tattgctatc ggcaatatga ttggcggaaa gctgtcaaac 2393581 cgaaatccga ttgccgcttt attctatatg tttatcgtac aggcaatcgt tctattcgta 2393641 ctgacattta cagccccgta tcaagcagca gggctcatta ccattctctg tatgggattg 2393701 ctggccttta tgaacgtgcc cggccttcag gtgtatgtcg tcatgctggc tgagcgtttt 2393761 gtcccgagtg cagttgacgt cgcatccgcg atgaatatcg ctgcctttaa tgcagggatc 2393821 gcgcttgggt cataccttgg cggtgtgatc accgattcaa tcggattgat tcataccgct 2393881 tggataggcg gattaatggt ggtcggtgca gtcattttaa caggctggag ccgcttgatg 2393941 gaaaaacgag atcggcagga agcctgacaa ttttaaagga ggaaataaac atgacaacac 2394001 atttacaagc aaaagcaaca cttcataatg gggtagaaat gccttggttc ggcctcggcg 2394061 tgttccaagt ggaagaagga tctgaactgg taaacgcagt taaaactgcc attgttcacg 2394121 ggtaccgcag tattgatact gcagcaatct atggaaatga agctggagtc ggagaaggga 2394181 ttcgggaagg cattgaagaa gcaggcattt caagagagga tctgtttatc acatcgaaag 2394241 tatggaatgc ggatttaggc tacgaagaaa cactcgccgc gtttgaaaca agtctgtcca 2394301 aactcggtct ggattatttg gatctatacc tcatccactg gcctgtagaa ggaaagtata 2394361 aagaagcttg gagagcgctt gaaacgctgt ataaagaagg ccgtatcaaa gcgattggcg 2394421 taagcaactt ccaaattcac catcttgaag atctgatgac ggcagctgaa attaagccta 2394481 tgattaacca agtggaattt cacccgcgcc tcacacaaaa agagttgata agatactgcc 2394541 aaaatcaggg catccagatg gaggcttggt cacctttaat gcagggacag ctgctggatc 2394601 accctgtatt ggctgacatc gctcaaacat ataataaatc tgtcgcacaa attattttgc 2394661 gctgggatct gcagcatggc attataacga ttcctaaatc aacgaaggaa caccgcatta 2394721 aagaaaatgc aagcgtattt gactttgaat taacgcagga tgacatgaac cgaatcgatg 2394781 cactgaatga aaacttgcgc gtcggtcctg atccggacaa ctttgatttt taatggccaa 2394841 aaaacaccgt tcaatatgaa cggtgttttt tgtattatgc ccagctgttc atgatttcat 2394901 caagctgcct tttggtctct tcaagcgtgc cgctgttatc aatgacttga tctgctcttg 2394961 ctgttttttc ctctaagggc atttgagagc ggatacggct gactgcttct tcttctgtca 2395021 gctgattgcg cttcatcaga cgttccagtt gaagctcttt tgtcacactg accacaataa 2395081 ttttatcaac caatgattcc aatttgcttt cgaacaatag cgggatatcc aatacaacaa 2395141 atgcctcccg atttgcaacg gcttcatcac ggcgattgag catttcctgc ctgactgcgg 2395201 gatgaacaat tgcatttaaa gcgagacgtt tttgttcatt tgtaaatacc agcgctccaa 2395261 gcttttttct atctatatcg ccatttgaga gcagtatgtc ttcaccgaat tcgtcaatga 2395321 tttgccggta ggccggcatc cctttttcta ccgcttgttt tgcaatgata tctgcatcta 2395381 taactgttat tcctttttca atcagcatat tggctaccgt gcttttgccg ctagctattc 2395441 ctcccgttaa accaatgact aaggtcaaga gatccactcc tttttacaat ttccagagcc 2395501 caatcgtgat taatagaagc cccggcaaaa acgccatttt atcgatccat ttccacttag 2395561 acagaaaatg gccggcattg attccaattg atacaaacag cgagctcatg attgccacgg 2395621 cgatgctcat cacaatcggc gaaaaaccga gaatggctgc gcctatacct gctccaaagg 2395681 catcaatcga taaggcaaat cccaataaga ccgcctcaat tccgttgatc acacccgatt 2395741 tgtcgatatc cgcactcatg ggttttctca aaatatgaat cacaattcct aatgaccgaa 2395801 cctctagatt aagcagtgtt ttttcatgca ataggtattc tttatctttt gccggtttga 2395861 aaaattgata cagaacccac gcaccgattc caaccaatat caaaccgcca agcttctccg 2395921 tcacatatac aggaaaaaac ttcgtgagaa agcttccgat cagcatggat ataaacatga 2395981 cagcaccgga acagcaggcg ataaccaaaa tcgctttaaa cggtattttc atttttctca 2396041 atccgtacgt aaatccgact gaaaaactgt ccaagctgac agccaacgcc agcagcagta 2396101 tagaaaccat ttgcatatcc gtttcttcct ttctgttggt gctcttgtat cagatgtgaa 2396161 atgcccggga ttcatcacaa tcatatatat gggaaagtga aaaatccgtg tttcgaaaat 2396221 ggcatcctta atccagagtt actgatatat gcaccgacag cttggacaat gaagcattat 2396281 gctacttttt tgtctggcac tttgcgcaaa aatgcgtgcc tcttcctcca acgacaattt 2396341 tcgaaatcat cgttccgcaa tttttgcatg gctcgtcttt ttttccgtac acaaaatgct 2396401 gcagctggaa cattccgatt tccccttggg agttgatata tgaacggact gtgcttccgc 2396461 ccgcatcaat cgcctcctgc agagtgtttt tgatttcagc gtgaagggtt ttgattgttt 2396521 tatctgataa ttgatttgct tttgtctcgg gatggacacc cgctctgaaa agagcctcat 2396581 ccacataaat gttcccgagt ccaactaccg ttttttgatc cagtagggca gttttgacag 2396641 cgcggtttgt tttcgcaagc cggtctttta aatacgcact tgtaaattct tctgcatccg 2396701 gctccggccc taactgagaa agcgggagct cgcccgcttc ttctcccggt ttaaataagt 2396761 gcatggttcc aaatttccgc acatccctgt accggagctg ggttccatcc gtcatcgtga 2396821 atatgacatg cacgtgttta tcgtcaggct cctcggcttg atgaagaccg tattttcctt 2396881 ccattcgaag gtgagaaacc ataacataat gatctaaatg aaacagtaaa aactttcccc 2396941 gtcttccgat ggactgtatc gtttctcctg ctagttttcg cgcaaattcc tccggttcgg 2397001 caggccgttt gatgatattc ggccatctga tctctaccga tttgattgtt tttcccttta 2397061 caagcccggt cagagtgcgc cggaccgtct caacctctgg taattccggc acatccatca 2397121 cttcctatct ctgtttattt cgcatcgtac caagatgggc ctgatgcaaa gtccaccttt 2397181 aacggcacat ctaatgcaag cgcatgctcc atcacttcag gaacaagctt ttcaagaatt 2397241 tcaatttctt cctttggcgc ctcaaaaatc aattcatcgt gtacttgaag cagaagcctt 2397301 gctttcaact gtttttcttt cagcttggca gccatgtcaa tcatggcttt tttgataata 2397361 tcagcggcgc ttccttgaat cggcgtattc atggccgtcc gctccgcaaa acttcggata 2397421 ttaaagttcc ggctcgtcag ctcagggatg tagcggcggc gatgcataag cgttgttacg 2397481 tatccttttt gtttcgcttc ctgtactgaa tcttccatgt acgcttttac gccttggaag 2397541 ctttccagat agcggtcgat aaatgctccc gcttccttcc gggtaatgcc gaggttctgt 2397601 gacagaccgt aatcgctgat cccgtaaaca atgccaaagt tgaccgcttt cgcctggcgt 2397661 ctcatcgcag atgtcacttc atccttagcg acatggaaca catccattgc cgttttcgtg 2397721 tgaatatcca tatcattagt aaaagcttcg atcagatttt catcctttga aatatgggca 2397781 agcacccgca gctcgatttg tgaataatcg gctgcaaaaa tgagccagtc tttttcagac 2397841 ggcacaaaag cttggcgaat tttccgccct tcctcaagcc tgatcggaat gttttgcagg 2397901 ttcggatcag tcgagctgag acggccagtt tgcgttaagg cctggttaaa tcgcgtgtgc 2397961 actttatgcg aatccggtct cgtcaccttt aaaagccctt cgatatatgt tgattgaagc 2398021 ttgccaattt gtctgtactg taaaatatag tcgacaatat catgcttgtc agccagcttt 2398081 tcaagcacat cggcagacgt agaatagcct gttttcgttt tctttacgac aggaaggccg 2398141 atcttttcaa ataagatgac gcctagctgt ttcggagaat tgatgttaaa cggctctccc 2398201 gcaatctcat ggattttttc ttcatattcc ttcagcttcg cacccagttc ttcacccatc 2398261 cgttttaaac ggtcaacatc gaccttgacg ccagttgatt ccatttcgcc aagaataagc 2398321 gcaagaggca tttccagctc ttcaaacagt tcaagctggt cgttgttttc cagctcttga 2398381 acgagctttt cccgaaggct ttgaatcgct aacgcttttc ggccaaggtg ctcagacagt 2398441 acgtcttctg acggcactgc ccgttttgct ccttttccat aaactgattc atcacttgaa 2398501 acgatatgca ggccgtaatc cttagccaca ctcgcaacgt cgtcatatga attgcccggg 2398561 ttgatgatat aagccgcaag gagcgtatca aactcggctc ctttcagctc aatgccctgc 2398621 cagcgcaaag cgacaacggc ccgcttgctg tcgaagaccc atttcttctg ctcgtcattt 2398681 tccacccatt ctttaaacac ctcagactca acggcaatgt ctttcggaat gaaataagct 2398741 cccgtttcat ttacgatcga aaatccgagg atcggctctt catgataatt atcgccaatc 2398801 tgttcaacga caaatgcgga tggagaaacc aatatatcgc ttgtcacgtc tgtgactgtt 2398861 ttgacattaa tgtcttccaa cgattgatcc tgttctgctt ctgcactgtc ttctccaagc 2398921 cgttcaagaa gcgtgttgaa gccaagatct ttaaagatgg caatgacctg ttcacgatta 2398981 aagccttgat attccaggcc ggaaacagat acctcaatcg gagcatccgt cataattgtc 2399041 gcaagctcct tgctcatcaa tgcctgatcc ttaaactcct caagcttttc cttcaatttc 2399101 tttccgctca cctcgtcaat ggactccagc agcttttcaa cggaatcaaa ttgttttaaa 2399161 agcttaatcg cagtcttttc tccgacgccg ggcacacccg gaatattatc tgaggaatcg 2399221 cccatcagac ccttcatgtc aatgatttgt tcaggcgtaa gcccatattt ctctttgaca 2399281 tgctccggtg tgtaaaattc aacatcggta attccctttc tcgtaatggc aactgtcgtt 2399341 ttgtccgttg ccagctgggt taaatcctta tctcctgaga aaaccttaac ttcaaatccg 2399401 tctttttcag ccgatttggc cagtgtgccg ataatatcat ccgcttcata ttgttccagt 2399461 tcatagcggc tgatctggta ggcatccagc agctcgcgga taaacggcat ttgttcggaa 2399521 agctcaggcg gggttttctg tctgccgcct ttatattctt taaatgtgcc gtgacgaaat 2399581 gttgttttcc cggcatcaaa cgcaaccagc atgtgcgtcg gtttttcatc ctcaagcatt 2399641 ttcatcaaaa tcatcgcaaa gccgtataca gcattcgtat gaacaccttt atcattgctt 2399701 aacagcggca atgcaaaaaa cgcccggtaa gccagactgt ttccgtctac aagcactaat 2399761 ttttttcgtt ccgtcattca atttcctcct aagaagcctc aggcttccat tcatctctta 2399821 catagtcatt agctcctctt attttaacaa agttcaattt gaaaggaaaa tacgtgaact 2399881 ataagagaag acacaaaaaa ggacgggaac acaaataggt tcccgccgtc aaaattggct 2399941 ccttggatga aggggttcta ctacatccta ccagcatagg tttaacagtg catgaagata 2400001 ttgttaaacc tttgtaaaca ttaggcggac ttttcagcgg cccgtttcag cgtcacggta 2400061 aagacagttc cccgtccaag ctcgcttgtg acatcaattt tcccttcatg agcctctatt 2400121 aaatgcttga caatcgctag gcccagcccg gttccgcccg aatttctgct tctgtcttta 2400181 tctacacggt aaaagcgttc aaagatgcgc ggaatttctt ctttctgaat tccgattcca 2400241 gaatcggcaa cctcaatctg aatgtctttt tctctgggct ttacattgat agccacggag 2400301 cccccctcag gcgtgtaggt taatgcattg tttacgagat taagaaatac ctgtttcagc 2400361 ctgtacgggt caccagatac atattgaggg tctttcggga cattcaggtg caaggagatg 2400421 cctttctcat ccgccttatg cttcagaagc gtttcaatct caccaagcat tttggccggc 2400481 tcaaacgttt cgatactgag cgtgaaattt tgctgctcga tttttgagag atcgagcaaa 2400541 tcctgaacca aagactgaag cctttcgctt tccttaagaa taatagagag aaattcagaa 2400601 agcgcctctt tgtcttccat cgccccgtcc aataacgtct ccgtaaaccc ttttatggac 2400661 gtaatcggtg ttttcagctc atgagaaaca ttggccacaa aatccttcct catctgctct 2400721 aatttcttcg tttccgtcat gtcatggaaa acgagcacaa ttcctttcca ttcatcgtcc 2400781 ggccccataa tcggaacgcc gtccacttca aaataacgcc gttctatttt gatcggcagt 2400841 cttaacagct tgcatttctt tgtctccgtc ataaaaatgt cttcgacaag ctggatcact 2400901 tcttcatgtt caaatgcatc gtgataaaga cggcgcagca tatgattcgg attgatatga 2400961 aactgcttgg cgtaagacct gtttacgaga ttaataaagc ctcttccgtc gatcataatc 2401021 agcccggagc caatgttttc aatgactgtc agcagccgat cccgctgcat ttcctgcgtt 2401081 cgcgtcattt ccatcagatc aatggcaagg ctgttcatcg catgtcctag cttatcagaa 2401141 cgcctaatat agccgccgta cgtccgtgca tcgtagttgc ccttagagag ttctgtggct 2401201 acatttgtcg ctgactcaat tgacctttta taacgtgagg tcatgctgga ataaaaataa 2401261 acaatgacga taaatgcggt acaaagactg gccgtcagca tcccccacaa ttcgcctttt 2401321 aagccgtcgc ttttttcaga ggcggaaagc agcacatatc ctgttttttc accttcgctt 2401381 ctaagtgaaa gtccgtaata aagcttgtta tctgttgttg acagaatacc ctcatggcca 2401441 gaaacaagcg cctgcacctt ttgggaatca gccgatctac cgtttgaccc atacagcacc 2401501 ttaccgtctg tatcgataac ggatgcgctc acatcaagcg cgccgcctgc atctttaatg 2401561 attttctcat ttgcttgatt attcagattg ccggcatcaa gaagcgaagc caagtatttt 2401621 gcttcttttt caatgtgttc ctctgctttc ctttgatcag atgtttcaaa aagctgctgt 2401681 aaaaacagcc cgaggacaca aaacaccaga atcatacaga caacgaatac agaaaaaagg 2401741 cgcacacggt atttattcat tcatttttgg ctcctccagt ttatacccca atcccctaat 2401801 cgttttaatg tagatcggtt ttttggtatt gttttcaatt ttgtcgcgaa gatggctgat 2401861 gtgcacatca acaattctcg tatctccggc aaaatcataa ttccagactg cgctcagcag 2401921 caggtctctt gtcagaactc tgcctttatg tctgcctaaa tagagcagca gttcgaattc 2401981 tttcggtgtc agttcaagct gactttcttt aaagtacgct tcataatgat caggcaggat 2402041 tttcagatcg ccgattacga tctggccttc catttcatcg ttcttcatct cactagaggg 2402101 cgcagctatt tccgaacgcc ttaaaatcgc tttgactctc gcatttactt cccttggact 2402161 gaacggcttg gtcatataat catcagcacc gagctccagc cctaatactt tgtcgaattc 2402221 ctcatccttc gctgtcagca ttaaaatggg aaacatcagt ttttgctgtc tcagctgctt 2402281 gcatacttcg attccgtcca attttggaag catcacatca agcacaatca aatcaggttt 2402341 ctctgtttcc gcttttttga gtgcttcttc cccatccgag gcggtaatga catcatagcc 2402401 tgaccgttcc aaattgtact gtaaaagagt aacaatagat tcttcatcat ccacaactaa 2402461 aattttcttg ttcatgctgt gcctccagta ttataattcc ccgacatcct atttctctat 2402521 tttatgtcat cttaacatgt ttcatgattt tattttagcg aaagcaggac attccgacaa 2402581 ttcgcctttt acatcatttt taaaagaaat aaagacgttt atgatagcgc tttcatttat 2402641 agtaaaaaga gaaaggctgt attaagcaag cctttctctc tttttattag gataatactt 2402701 tcatgacatt tttgacagat tcaactgatt tattcagctg cgctctttca tagtctgtca 2402761 gttcaagttc aatgatttgc tcaagaccgt tgccgcctac aattgtagga acaccaaggt 2402821 agatgccttc atagccgtat tccccttcaa gataagcaat tgtaggaagg acgcggcgct 2402881 gatctttcaa gatcgcttcg accatttctg tcagagaagc cgcaggcgca taatacgcgc 2402941 ttccgtttcc aagaagattc acgatttcgc ctccgccttt tctagtgcgc tccacaattg 2403001 cgtcaatccg ttctttcgga ataagagttt caagcgggat accgccagca taagaataac 2403061 gcacaagcgg aaccatatcg tcaccgtgtc cgccgagtac gaaaccagtc acatctttca 2403121 ctgacaggtt taattcctct gccacaaatg ttctgaatct tgccgtatca agcacacctg 2403181 actggccgat tacacgctct ttagggaagc ctgattcttt gtacaccgcg tatgtcattg 2403241 catcaacagg atttgtcagc accacaataa tagagtcagg agaatatttc acgatttcct 2403301 gcgtaacgct tctcataatc ttttcgtttg tagagaccag atcatctctg ctcataccag 2403361 gttttcttgc gataccggct gtaatgacaa caatgtcaga gccggctgta tcctcgtaat 2403421 tggatgttcc cgtaattttt gcgtcaaagc cttgaaccgg gcttgcttca agcatatcaa 2403481 gcgcttttcc ctttgtcggg ttctccaatt gcggaatgtc aacaagaaca acgtctgcca 2403541 gctctttttg agcgattaaa aatgcagttg tagctccggt aaaacctgct ccgataacag 2403601 aaactttttt acgagtattt cccatgtctc tcttctcctt tatggctagt tttaggcttt 2403661 ttccttgctt agtccatgtt tttgatcagt tcttctccga actctgaaca tttcacttca 2403721 gtcgccccgt ccattaatct ggcaaaatcg taagttacga ctttagaagc gattgttttt 2403781 tccatagatt tgataaccaa atcagccgct tcgttccatc ctaaatgctc aagaagcaga 2403841 acgcctgaaa gaataactga agatgggttt actttatcaa ggcctgcata tttaggagcc 2403901 gttccgtgcg tcgcctcgaa aatcgcatgt cctgtttcgt agttgatgtt cgctccagga 2403961 gcaatgccga ttccgccgac ttgcgcagca agagcatcag aaatgtaatc tccgttcaag 2404021 ttcattgtcg caacgacatc aaactcgttt ggacgcgtta agatctgctg aaggaaaatg 2404081 tcagcaatgc tgtctttgat aatgattttt cctgctgctt ccgcttcgct ttgcgctttg 2404141 ttggcagcgt cttttccttg ttcttcagca atgcggtcat attgagccca tgtgaagact 2404201 ttatctccgt attctttttc agcaagttca tagccccagt ttttgaaggc gccttctgtg 2404261 aacttcatga tgtttccttt gtgaacaagt gttacagatt tgcggccatg ctcgatcgca 2404321 taatcaatgg cagctctgac caagcggctt gttccttctt ctgaaacagg cttaatgccg 2404381 atacctgatg tctcagggaa acggatttta ttgacgttta actcattttg aaggaagctg 2404441 ataagctttt gcacttcttc agagcctttt gcatactcga tgcctgcgta aatatcttct 2404501 gtattttcac ggaagatgac catatcagta tcttcagggc gttttaccgg tgacggcact 2404561 ccagtaaagt atcttacagg tcttaagcag acgaataggt caagctcttg tctgagcgct 2404621 acgttcaaag aacggatacc gccgccgaca ggtgtcgtta acgggccttt aatcgcgatg 2404681 aaatattcgc ggatcacatc taatgtttca gcagggagcc actcacctgt tttattataa 2404741 gccttttctc cggcgtaaac ttctttccat gtaattttct tttcgccttt gtatgctttt 2404801 tctactgctg cttccaaaac cttcgaagcc gcgttccaaa tatcaggacc ggttccgtct 2404861 ccttcgataa atgggataat cgggttgttt ggtacgttta atactccgtt agagactgta 2404921 attttttcac cttgtgccac aataaaaacc tcccagtatg taattcatat ttagaaaaca 2404981 ttttattttt cttatataga aaataaaatg atttttccta acattcaatt taaagtgtaa 2405041 cccaattttg atgtctgaac aagaggctaa cctcattgac gcaagccagc ctccaatggt 2405101 tctttaggct ctttcttcaa tcggaacgaa tttttgtttg tcagggcctg tgtaatctgc 2405161 ccgcgggcgg atcagacggt tgttgtcata ctgctcaaga atatgagcga gccagccgga 2405221 cattctgctt acagcaaaaa tcggtgtaaa caaatcatgg tcaataccga ggctgtgata 2405281 tacagaagcc gaatagaaat caacgttagg cggaagcttt ttctctgatg tgacgatgtc 2405341 ttctatacga atcgacatct cataccattt gctttcgcct gtcaggttgg tcaggcgctt 2405401 gctcatttct ttcagatgct tcgcgcgcgg atcaccatgc ttatacacac ggtggccgaa 2405461 tcccatgatt ttttctttct tttcaagttt agcgcggatg tacggctcag cgttttccac 2405521 ttcaccgatt tctgtcagca ttttcataac gccttcattc gctccgccgt gaagaggccc 2405581 tttcagcgcg ccgattgctg cagtaatgcc tgaatagatg tcagaaagtg ttgcgacgca 2405641 gaccctcgct gtgaacgttg acgcgttcag ctcatggtca gcatgtaaaa tcaatgcttt 2405701 gttgaaggct tcaacttcaa ttggtgaagg ctcttcaccg tttaatgtgt aaagaaaatt 2405761 ctccgcaata ccgtaatctt ctctcggttc aacaggctca agacccttgc gaattctgga 2405821 aaacgctgca accaggccag gcacctttgc ctgaaggcgg atcgcctttc tgtagttggc 2405881 ttccgggttc atggtatcag cctcgctgtc aagcaggcct agtaatgaaa ttgctgtccg 2405941 aagagcagcc atgggatgaa cattttcgag ggaataagat ttgaagtgct caataatttc 2406001 ttgcggaacg gcagcttcct ttgcaagctg ctgctttaac tcttcaagct cttttttgtt 2406061 tggcagcctt agatgccaaa gcaagtagat gatttcttca aaacttgcat tctctgtcaa 2406121 atcatcgata tcatacccca catatgtaag ggtatcatca ataatagaac taacagatga 2406181 tgttgttgct acaacccctt caagaccgcg tgtcgctgtc atatataaca tctccttttc 2406241 aataaatttc ccctttaaga gtgttgtaaa aacatgaggc ttacttaaaa agcacgatgc 2406301 aagtatttct ctcccccaaa aagaaaatgc ttacatttta ctggctgctg gaactaaaac 2406361 cctttgcttt tgaaagaaca taacaaattt ttataagctt atttaagttt aagcctattc 2406421 tcattataaa caataatcag acatttgtta aatgtttacc tataattttt tttttccatt 2406481 ctgtgatttc cccgaaaaaa cgcctttatt tgcgggtttt tgcataaaaa aaagcggctt 2406541 taaggccgct tttttttatg aagtgaacag ttttacgatc tgcatggcta aataagcaat 2406601 ccccgctccg atcagcggcc ccaccgcaac tcctccaaaa agcgcgactg caagaatggt 2406661 cccgatcacg agagcagttg taatatgcgg atcattttca agcagggtca ggccgttttt 2406721 tgcaatcagc gccactgcga tccccgctcc aagggcgatc catgcgtagg aagaccgcat 2406781 tgcttctcca agctgcttaa atccgatttc tcccgtggca atcgggacaa gaacggcgat 2406841 ggtaataatg gtcacacccc agttaatgcc ttttgactgg atggtcggaa ataatttctg 2406901 atcaagccca acgattttga tgatcaaaag gacggataca gcaaagagca atgattggtt 2406961 ttttgcgata agtgcgatag ccaagagtaa aattaaaaat aaattcgctt gtgtaaacac 2407021 atgccatccc tcctttaaga tgaatgtatt catattcagc cgcagcgtga atacatataa 2407081 aaaataggac atgctgacga gaggaggacc gtttttgtga atcaatctta tatcactatt 2407141 tttttcagaa ccctctttgt catatcaatg accgcagggt cgatagctgc ggcctattat 2407201 tcgtttccgt taacttatcc gttcctgatc gcccttattc tatcttcagt gattcatcct 2407261 gttgtcgatt atttggacaa agtgacagga ttcccccgaa cgataaatgt tctgggcgtt 2407321 cttgcttttt ttctgctcgc agccttcggc gtgctcacca ttctggtagc cgaaatcgta 2407381 acgggaacag cctatctagc aaaaacgctg cctccgcata tcagcacgtt tatttcatat 2407441 tgcgaaaaat tgtttaccac tcatattcag ccgctctata acgagttaac tcttttgttt 2407501 caagaattgg aaacgaacca gcaggcttcc atcgtcactc atatccagac actcggtgat 2407561 tctgccgcta aaaatgccgg gctcctgctg tcccacattc tagagatgat cccgagattt 2407621 ttcgctcttc ttcccaatac ggcggcggtt ctgatttttt ctcttctggc aacctttttt 2407681 atgacaaagg attggcataa gctgaaagcc atgcttgttt taattctgcc ggatcgtgtg 2407741 acagctaaca gcaaagcaat cagcagcgaa ttaaaaaaag caatgactgg ttttatcaaa 2407801 gcacaagccg tcctcgtttt catcacgatg gtgattgtat ttatcggcct ttctctctta 2407861 aaggttgaac acgccgcaac aattgctttt ttaatcgggc ttgtagatct tctcccttac 2407921 ttaggtgccg gctccgtatt tgtgccctgg attttgtatt tatcgattac gggccagctg 2407981 ccccaagcaa tcggaattgg tatcctgtac ctcgtcgttc ttattcagcg gcagctgaca 2408041 gagcccaaga tactaagtaa atctatcggg atcgatccgc tggcaacact catcgccctg 2408101 tttgccggct ttaaattatt cgggttttta ggactgattg cgggaccggc tgtactcgtc 2408161 atcatccaag ctttcatcac aacaggcgca ttaaaagaaa tatggtccta tatcaccgtt 2408221 cagcaaaaat aaaacggcag ccgttttttc atggctgccg ttttttattt gatgatgatc 2408281 cgcttattct tcgacattcc tctcagccat ttgaacagaa tcggcttaca ccagccgcgg 2408341 gtaaacggga taagaagaca ggcgccggcc aaatctgata aaaagcccgg aagcatcagc 2408401 aatagaccgc caatgaaaat gcacagaccg tcagcaatcg cttctcccgg cattttgcca 2408461 tattgaagat cacgctgaac cttataatac acttcggttc cttgtttttt tgcagctgct 2408521 gcgccgataa tgccagtcag aatcatgaat agaactgtcg gcaaaatacc aatcagattt 2408581 cctaaaaata ggaatatacc gatttctatt gccggaaaca caataaaaag caaaaacaaa 2408641 aatctcatat ccaagccccc cacacgtgta acacgttctg ttcaacaaaa ggcatgataa 2408701 agagaaaagg aagggattcc ccttccattt tcacctgtaa ttaaagaacg ctcgcacggc 2408761 cttgatagac tgcgcctctg gaagcgtcaa ctgtaatatc ctggccatct gtcaaaatag 2408821 atgtcgcatt ttccagaccc acgataaccg ggatgccaag gcttaatccg actaccgcag 2408881 catggctagt caaaccgcct tcttctgtaa taagagcaga cgctttttca agggatgcaa 2408941 tcatatcacg gtcagtgctt ttggtaacaa gtaccgcacc gtcagtcatt ttttgctcag 2409001 cttcttttgc attttgtgca acgacaaccg gaccgtaagc tgatttgcgt ccaatgcctt 2409061 ggcctttagc gatgatatcg ccgacagtat gaaccttcat taagttcgta gtgccggact 2409121 caccgacagt gccagctgta ataacgataa gatcgccgtg ttttacaatt ccgctgttca 2409181 atgatttttg gacagcatcc tcaagcatct catctgttga gctcgcattt tggccgcttt 2409241 ccgcgaatac gccagatacg agggcaagct ttctggaaat agagtcattt acagtaaccg 2409301 caacaatcgg agcctgcgga cggtattttg caatcatacg tgctgtatgg ccgctttctg 2409361 tcggcgttac gatcgcagca gcattcaggt taatcgccgt atgtgcgaca gattgtccaa 2409421 ttgcgtctgt aattgtcatg cccacttggt ctctgcgttt tgagagaatt tctttataat 2409481 ttaatgcttc ttcagaacgg gacgcgatgt tatgcattgt ttgaactgct tcaaccgggt 2409541 aacttccggc agcagtttca ccagaaagca tgatcgcatc tgttccgtcg aagatcgcgt 2409601 ttgcaacgtc acttgcttcc gcacgagtcg gacgcgggtt gcgctgcatg ctgtcaagca 2409661 tttgtgtcgc tgtaataaca ggtttgccca gcgcgttgca ttttttgatc agttcttttt 2409721 gcacaagcgg cacttcttca gctggaattt ccacacctaa gtctccgcgt gcaaccatta 2409781 agccgtcaga cacttcgaga atcgcatcga tgttgtcaac gccctcttgg ttttcgattt 2409841 tagggatgat ttgaatatcc tgagcgttgt gctcttcaag aagctcacgg atttcgagca 2409901 catccgtaga acgtcgaatg aaagatggtg cgatgaagtc tactccttgc tcaataccga 2409961 aaacgatgtc tcgcgcatcc ttttcagtaa tccccggaag attgacactt acgcccggta 2410021 cgttaacacc ttttttattt ttgagtgttc cgttgtttaa tacttttgtt ttgatttcgc 2410081 gtttagcggc atctacatca agtacctcaa gaccgataag gccgtcatct aacagaatcg 2410141 ttgaaccttg ttcaacgtca tggactaaac cttcatatgt cactgaaatt ttatctgttg 2410201 ttcctacaac ctcgtccatt gaaataatga gctctttgcc tgtttcaagc tcaataccgc 2410261 cgttttccat tgtatgtgtg cggatttcag gaccttttgt atcaagcaga attccaacgt 2410321 tcttgccaag ttttttactt gcttcgcgga tatttttaat tcttgcaccg tgctcctcaa 2410381 aatctccgtg agaaaagttt aatcgagcca cgttcattcc tgactccatt aatttcgtaa 2410441 gcatttcaat actttcactt gccggaccga tggtacaaac aattttagtt tttctcattt 2410501 ggttcacttc cttctgaaat cttcagcctt cagctgtaca ttagatagac agttcttttg 2410561 aaagctgata catgttttgc tcaactgtgt gttttgtctc aagtatttct ataatatcat 2410621 ggtctacaag cttattgttt tgtataccta cacagcgtcc gccttttcct tcaagcagca 2410681 gttcaactgc atatgcgccg agacggcttg ccaacacacg gtcagcagca ctcggagaac 2410741 ctccgcgctg gatatggccc aatacagata ccctagtttc aagatttgtt tcttcttcaa 2410801 tgcgtttccc gaattcaaca ccgctgccta caccttcggc aacaataata atactgtgct 2410861 tcttgccgcg ttcgtggccg cgttttaagc gggcaatgat ttcgtgcatg tcatagtctg 2410921 cctcagggat taagatcgat tctgcgcccc ctgcaagacc ggcccacaat gcgatatcgc 2410981 cggcatgacg gcccattact tcgattacat atgtacgttc atgagaagtc gctgtatcgc 2411041 gaatcttatc aattgcgtca attactgtat ttaaagctgt atcgaaaccg attgtaaaat 2411101 cagtgcccgg aatgtcatta tcaattgtac ccggtacacc tacacatgga aacccgtgtt 2411161 ccgttaattt tttcgcaccc atataggaac cgtctccacc gataacaaca aggccttcaa 2411221 taccaagctt cttcaagttt gctatccctt tttcacggcc ttcaactgtt ttgaattcag 2411281 gacatctcgc cgtataaagc ttagtccctc cacgatgtat aatatcgcct actgatccga 2411341 gttcaagctt ttcaatcttt ccgctgatca atcccgcgta tccgttgtaa ataccgtaaa 2411401 cttcaacgtc atgatagatc gcttttctga ctactgcgcg aactgctgcg ttcattcccg 2411461 gggaatcccc gccgctcgtt aataccccta ttcgtttcat tctccattca cctcagcaac 2411521 atatatgatt aaacataaca tgatcattgc cctaaaaaca atgaaaaggg atctccatcc 2411581 tccctatgaa accttaccta ttatacaatt aaataaattg tttttaaata aaatttaagg 2411641 aatgtcacaa aaaataaacg tgagccaaag gcttcacgtt tatttagttt accccgatat 2411701 attgatcttc aaccgagact ttgccaattg ctttatattt ttcataacgc tgctgaacta 2411761 attcttcttc gctcagcttc agtaaagttt ttaacgattg tttaagggtt tcgtccatat 2411821 agcttgcctg cagcttcaca tcatggtgcg ctccgccttt tacttcttta atcatatgat 2411881 ctataatacc taattctttt aaatccggcg cagtgatttt cattgtttct gctgcttttt 2411941 tagcaagact ggagtccttc cataaaagtg ccgcggcacc ttccggagaa ataacagaat 2412001 aagtagagtt ttccagcata tgcaagtgat tgcctacacc cagaccaagg gctccgccgc 2412061 ttccgccttc accaatgacg atgcagataa caggcactcg aaggccggcc atctcaaaca 2412121 ggtttttggc aatagcttca ctttgtcctc tttcttcagc tgctcgtcca gggtatgccc 2412181 ccttcgtatc aataaaacag ataattggtc tgttaaattt gtcagcctgt ttcatcagac 2412241 gaagcgcttt tctgtagcct tctggatgcg gcatcccaaa attgcggact aggttttcct 2412301 tcgtgtcttt gccgcgctga tgcccgatta ccgttacagg gaggccgtgg aacttcgcaa 2412361 tcccgccgac aatggcttca tcgtccccgt acgctctgtc tccgtgacat tcaaaaaagt 2412421 cggtaaacag gtgttcgata taatcaagag ttgtcggacg gtccgccaga cgcgcgattt 2412481 gaacccggtc ccacggcttc aaatttttgt aaatatcatc ctgaagctta gcgagacggt 2412541 cttcgagccg ttcgatttcc gcacttagat ccatatcgga atcttgggtg aattttttta 2412601 gttcggcgat tttggtttgc agttcaatca ccggtttttc aaattctaat cttggagcca 2412661 ctcaatgtca cctcctgttt gatgcatatc cagcagattt tctaacgttt ttttcatatc 2412721 gtcgcgatga ataaccgcat caagctgtcc atgttttaat aaaaactcag ccgtttggaa 2412781 gtcctcaggc agtttttctc ctattgtctg ttcaataatc cgtcttccgg caaaaccgat 2412841 cagcgcgcca ggctcagcga aattgtaatc gccaagggat gcaaagcttg ctgatacgcc 2412901 cccggtagtc ggatgcgtca ttactgaaat aataagaccc tgttcttcac tgaacagttt 2412961 taacgcagag cttgtctttg ccatctgcat caaacttaat acgccttcct gcattctagc 2413021 accgcctgaa gccgtaaaaa taataaacgg aactttatca gcttttgctt tttcaatcgc 2413081 aagcgtgatt ttttcaccga cgactgaacc catgctgccc attctgaatg aagagtccat 2413141 gacggcgaca acagccgggt gtccgccgat ggtgcccttg cctgtcacaa cagcctcgtt 2413201 taaggatgtt ttctcgcgat ctttttcaag cttttccaga tatcccggga aaccaagcgg 2413261 attttccgag agcattccct gattaaattc ctcaaaggat tgttcatcca tcaagctttc 2413321 gatacgctgt tttgcgttca ttgggaaatg ataatcgcag ttcatgcata cccgcatatt 2413381 tttatccaac tctttagtga gcatgatttt tttacactta ggacattttg tcataatgcc 2413441 ttccggaaca tcgtgcttcg cttgatcaga cggtacggaa gcatactttt tctttttcgt 2413501 gaatatatcc tttaacaaat gattacctcc cttttgtgaa gggttctctt caccgcatgt 2413561 catcaaacag atagacttgc taataacttt accgaaacta ttgtactttt tttgtcaaac 2413621 gctgtcatcc tcaattcgac aactttttat tcgatgacgt gctcggaaag gcttgtatga 2413681 aatcagataa ggtgttgaaa cgacaaggtt gacagcgcat tcaaaaataa tgttaaaccc 2413741 ggctgaaatt tttttaaggc taacccccta aaaaaatttc agccgtcagt ttaacttgag 2413801 aacagcgcgc cggtctccgc caacgcgctg ccatttttgg aatgaattaa aattattcac 2413861 caataatcgt aagttttctt gttttttctg cgacttcctc agggtcaaca gtgattcttg 2413921 caacacctgt ttccatcgca gcttttgcca cagccttcgc aacagcaggc gcaacacgtt 2413981 tatcaaacgg tgcagggatg acatagtctg cgctaagctc atcttctgaa accagtgaag 2414041 caatggcttc aaccgctgcg attttcattt cctcgttaat atgagtggca cgcacatcaa 2414101 gcgctccgcg gaaaatacca gggaatgcaa gaacattgtt tacttggttc gggaagtcag 2414161 aacggccagt tccgacaacg cttgctccgg cttcacgcgc atcttccggc atgatttccg 2414221 gatttggatt tgccattgca aagataatcg gatcttttgc catgctttga accatttctt 2414281 ttgttaacgc gcctgctaca gagacaccga taaatacgtc agcatcaacg ataacatctt 2414341 tcagagaacc gtctttgcga tcttggttcg tgaacttcgc cacttcattt ttgacatcgt 2414401 tcatgccgtt cgggcgccct tcataaatgg cccctttgga atcgcacatc acaatgtcgc 2414461 gaacgccata atgatgaaga agcttgataa tcgcaatgcc agccgcaccc gcgccgtttg 2414521 cgacaacttt aatggatgac atggattttc cagacagttt cagcgcgttc acaagacctg 2414581 ctacggttac aatggcagta ccgtgctgat catcatggaa aaccgggatg tttgtttctt 2414641 ttttgaggcg ctcttcaatg ataaagcagt ttggcgctgc aatatcttca aggttgacgc 2414701 cgccaaatgt cggttccagc aattttacag tttcaacgat tttatcaaca tcgtttgtgt 2414761 ttaaagcaat cgggaacgca tctacgcccg caaagctttt gaaaagaact gctttccctt 2414821 ccataacagg aagcgccgct tcagggccga tgtttccaag gccaagcaca gctgtaccgt 2414881 cagttacaac tgctaccatg ttccccttca ttgtataatc atatactttg ttaatgtctt 2414941 catgaatatc cttacacggt tctgcaacac ccggagaata cgcgaggctt aaatctttcg 2415001 catttctgac ctctactttt gatttagact ccagtttccc ctggttgact ttatgcaggt 2415061 gtaatgcttc ttctcttaat gacattctcc taaacactcc ttatggatat tttttgattc 2415121 gtatactgct gcgttgattg ctgcattctg cggagtaaat ctatctgaat atttaaacag 2415181 gatcacataa ttgctccaat tgtataacaa aaagcgaatc gttaccactg ttttaaaacg 2415241 acgttttttt gacccaacag ctcttttaag cgatataaca cctggtgatc tgcattgata 2415301 tggaacgact caggtagctt aatcgtctgt ttttgccttt cataatagag ataaacgcct 2415361 gtttcccctt tatgctccag caaaatgcgc ttaatctttg ccaggatctc ctggctgtgc 2415421 tgactgcttt ctatttttat ataaaccgat ggcgcttttt ctgcatccat atcttctaat 2415481 aattctgccc gggacatgat gaattggatc ttatcttgtc taacttcaca tttccccgca 2415541 gtgaacaaaa gagcgccttc tcttaaaacg ggagaaagct gtctgaattg ttcagggaag 2415601 actacggctt ccatctcgcc ggtttcatca ctgagcgtta aaaacgccat gttttgacct 2415661 gttttcgtcc gaatcgtttt gatcttcgac agcagaacgc ctagtgaaag ctgccttttg 2415721 actgcccgct gagcctgcag aatggagact gctccttgcg cagtgagctg ttttcggaag 2415781 gcggagaggg gatgatttga aaaataaatg ccaagcgttt ccttttcaaa cgcaagtaaa 2415841 tccaccagag gaagctcctc cgtctccaca tacttcggct taattgaaaa cgattcatct 2415901 aaaaacaatc ccatttggtc atcgtccgcg gcgaatagct cagcatgttc caaagcaaca 2415961 tcaatggatg cgagcagcgt ggcccggttt tggccgaatt cgtccatcgc accagaaaag 2416021 ataagtgctt caagcatttt gcgatttacg ctttttgacg gcacgcgaaa gcagaaatcg 2416081 aaaagatctt caaatggttt ctcttttctt gctttatata tatctttgac tgctgagacg 2416141 cctacacttt ttatcgcgcg gaggctgtat ctgacagatc cgttttcaac tgtaaacgga 2416201 aaactgcttt tattcactga cggaggaagg atacgaatcc cgctcccctt tgcttcgtaa 2416261 agatattgag agattttatc ctcattgcca atgacgcttg tcagcaatcc gcacataaaa 2416321 tataacggat aatgagcttt caaatacgca agctggcacc cgatcatgct gtatgccacc 2416381 gcatggcttc tgttaaagcc atagtttgcg aatttgacga ttaaatcgta gacctcattt 2416441 gcagtgtcta cagaatactc cttttttaag cacccttcaa caaaatggct tcgctctctg 2416501 tccaggattt cttttttctt tttgctgacc gcccttctca ataggtccgc ttcgcctaaa 2416561 gaaaaccccg ccatacggga agcaatcatc ataatttgtt cctgatacac aatgacgcca 2416621 tatgtatctt ccaaaatgct ccttaaatct tcatgaggat agtgaacagg cgcccgaccg 2416681 tgtttacggt cgataaataa cggaatattt tccatcggac ccggccggta cagtgcattg 2416741 accgccacaa tatcttctag gcccgaaggt ttcagccgtt tcaagacgct tctcatccct 2416801 gcagattcaa gctggaaaat gcctgtcgta tccccttttg acagcaagga gaacgttttg 2416861 tcatcgctgt aggaaatact tgaaaggtct attttaatat tttcttcttt ttcaatcatt 2416921 gaagtgatgg attcaataag tgtcagattc ctcaaaccta agaaatccat ttttaaaagg 2416981 cccaagtctt caagatggtc catcgcgtat tgcgttaaat agatcccttc atgcccttct 2417041 tgaagcggaa caacatctgt taacggttct tcactcagga caacgcccgc tgcgtgggtt 2417101 gatgcatgcc ttggcagccc ttctattttc cgggcaattg aatagacttg ctgaagcagg 2417161 cttgactccc gaagccgctt atccagctgc ggtgactgct gtctcgcttc atccagcgtc 2417221 attcccggtc ttgaaggaat gagttttgca agctgatctg cctccttcgg gctgacgccg 2417281 aatactctgc cgacgtcccg gagcgccgcc tttgccgcaa gtgttccaaa ggtgataatc 2417341 tgtgcgacgt gcattgcacc gtatttctgc tgaacatatt gaatgacttc atcccttcta 2417401 gtatcgggaa agtcaatatc aatatccggc atgctgacgc gttcgggatt taaaaatctt 2417461 tcaaacagaa ggtgatgctt aatcgggtca acatctgtga tatacagcac atatgccaca 2417521 agagaacccg ccgcagaacc ccttcccggt cctgtaacaa tccctttttc atgggcgtgc 2417581 ttcataaaat cccacacgat cagaaagtaa tcgctgaact tcatccgctt gatgacatca 2417641 agctcatatt gaagacggcg aaggtatcgt tcatcaggct tgccgaaacg gctgcggagt 2417701 ccctccatac agatatccgt taaataatca tcagcggacg ttccgtctgg ggtcggaaaa 2417761 gacggtagac gggtctgccc gagactgacg tcaacccggc attgttccgc gatctctaca 2417821 gaagcttgca gtgcctcggg atgctctcga taaatgtttt gcatttcttc gagtggtttc 2417881 aaatcgagat caggcaaatc ttcagcgggt gcatccgtca gtttttcccc cgctttaatc 2417941 gctttcaaac aacggtaggc agccttatct tccttcctta tgtaatgcac atcgcctgtg 2418001 gccgtaacag ggatacccgt ttcttctgac agctttagaa tctgctcaga caagacttga 2418061 ttccctttaa aaggctgata ggagaaataa aaagctccct ttccgaatat agactgaaat 2418121 tccagcgagg cttgagcagc ctgttcgaac agccctcctt caagaagcgt ttcaatatat 2418181 cctttttcgc cgggcgttat tgcgataatc ccttctcgat aactgtgaag ccatttcggc 2418241 ttcagtccgc cttttgattt agattgcaga acgctgctga ttttcagcag gttttgatag 2418301 cctgtattcg attttgccag caggacgagc gggtatgctt caagctcgct gtcatctgta 2418361 aaaacagaag ccgtcaaacc gattattggg ttgatccctc tcgccttgca agctttataa 2418421 aattgaatag ctccgtacat gacatgatca tctgtcagcg ccaaagacgc atatccgagc 2418481 ctgtcagctt cactgacgag ttcttccaca gccgcggcgc tgtttagcag gctatacccg 2418541 ctatgcactt gcaggtgaac aaaagacatg ctatcacctc tttctcatta cgatccattt 2418601 cttccttcat tataaggccg gtttccaaaa gaaacaaatg ttcttttttg actcatcatc 2418661 atacttgtcc tgaaagctca atatgatata aaaggtgagg tgataaagat ggatcaggaa 2418721 gcaggattta tggtgaattt tatcaatagc tacttcattg cgttaggggt gctgatcggg 2418781 ggcgcactca tcggagggct cggagcatac ttggcaggcg aacccccgct tacagccatt 2418841 acaaagcttg ccaaccggtt aaaaatatgg gcgcttgtcg cagctatcgg aggcaccttt 2418901 gatgcggtat acagctttga acgcggcata ctcgaaggca atacgagaga tatctttaaa 2418961 cagcttcttt taattatttc ggccatgggg ggcgcgcaaa gcggctggct tattatatca 2419021 tggctgaccc aggagcatct ttcttcatga gggtccccca gcattacaaa aaaccgggat 2419081 ggcagcgttt tttcgcggga atgatgtgcg gagccgtaat cagctggttc tttttcctgt 2419141 ttacttacgg aacattccaa gaggagcagg tcagcctcat cgaaaagcaa aaagagcatg 2419201 taaaagactt gaacaatcaa atttcgatct atcaggaaga cctccataaa ctgaatgaag 2419261 ataataaaag aaaactgctg attcaaagcg tcagcgtcaa attgctgaat ggggataaat 2419321 ataaaatatc acagccggat aaaacgaaat tcgaggagca tgtaaaggat gatatttcag 2419381 aggtgattac aaaagacata gagagcgtct atcaaacaaa ggatctcttg aagcggacaa 2419441 ttgaaaataa agtctatatg atcaatgaaa aaaaatacga ggcaaccgtc agagaattga 2419501 ttatttatac gaggctgaca gtggaacttg aaatttcttt cgccacataa ttatggattt 2419561 tttttaaatt ctccaaactt ctgtcgcttt ttcccattct tttttataaa ctatatgtga 2419621 ggcttaatgg cgaaaggaag gaggaaggga aatggaggtt tacagtgacc gtcagttagc 2419681 aaaagatcaa gcagcccgtc tcagacaagg tttttctgca tatgccgaaa caaactcact 2419741 cgcttccctc atcaaaaaag aacttcaatc acacaatctc caagtctacg aggaccttac 2419801 tgatttcggc tgctggttca tccccgtcac agatgaacac taagagagag ggtctcccct 2419861 ctactcgtgt tctttacata atgtttccag atcagctaaa atacgatcag cttcatccca 2419921 gctgtaaata gaggcgcctg aagctaacgg atgccctccg ccgttatatt tccgggcaag 2419981 tccgttaatg acaggcccct tcgaacggaa tctgactctg atttgatcgt cttcttctac 2420041 gaaaaacacc caggcgcgaa tacctgagat attgccaagc gtcccgacaa gctgcgacgc 2420101 ttcagaagcc gttgtgccga atttttcaag cgtatccttt ttgatgaaaa cagaagccgc 2420161 cccgttttcg gacaaagaca cattttgaaa gataaagccg ttaagcttca ccacattcag 2420221 ttttgtttca tacaattgat taaataactc tgaggaagag aatggatact gaatgagctc 2420281 gcctgcatat tttagtgttt tttccgtggt attcggaaat aaaaagcgtc cggtatctcc 2420341 aacaatgccg gcgtagatca gctctgccgc tttcgtattc agcttccagc cgtgctcttt 2420401 tccttctaaa tacagctcgt aaatcatttc acttactgag ctggcgcttg tatcgaccca 2420461 gagaaggtca ccgtatggat cttcgttcgg atggtggtcg attttcatta gtttggcgcc 2420521 tgaaggataa cgctgatcgt cgattctttc ctgatttgcc gtatcgcaga caatgacaag 2420581 tgcgccttca tatgtttcat tgtccacctc atcaagggaa tataagaaag agagggacgg 2420641 ttcaggcgtg ccgaccgcaa aaatattttt ttcaggatat gtttcacgca ggatttccgt 2420701 aagcccacac tgtgatccgt aggcatccgg atcaggacgc acatgtctat gtaagataat 2420761 cgtgtcatat aatgatatgg ttctgatcaa ttctgttttc atttgatact cctttattgt 2420821 ttttattcat taaatcacat tctctgccga cggaaaagaa aaataacgtc aaaaccaagc 2420881 ccgtttttgt ataaaatggg gttgtaaact tttacgatgg aggatttcat ttatgctggt 2420941 tcttgttttt ttgattgggc tttcagcctg cttttatgtg tactataaag taaaaggcgt 2421001 acgggcaaag ccatctttgg caaaagaaat atgttcagca aaatcaagca tggccttagg 2421061 gtcactagtc ctgttctacg ggcttaacca aatgatatta ttccattcag tattaacgtt 2421121 agtaatcggc ggtatcttta tcgtcatagg agcaggaagc gcttgggcag gttataaagc 2421181 cttcaggcat tacaatcccc ttcacgccaa agaagctgaa agagatcacg cgtaaggggc 2421241 gcctgaacgt cccttagctt ctttccatca gctgaaccat cagcatcgct ttagacacga 2421301 tatgaccttg gctgtgcact tccacttcca ttttcccaaa ctttctgccg gcctccaaga 2421361 tgcgaggttt gacttcgatg actgattcca tctgcacagg cttcaaaaag aagatggtga 2421421 tgctctctat gacgagttcg ccgcgttttt tcgagcgcaa aaatcggttt gccgcttgcg 2421481 tcaaaatggt cgtaaatacg ccataagaaa tggttccaag ctgatttgtc atttgcggcg 2421541 tgacttcata ctcgtaaacc gtttgatctt ctttatcatc accctcatct ttaaaccccc 2421601 ttgaaacgat atcatcaagc ttctccccga cctgcggctg cttttgaatc atttgaagag 2421661 ctttcaatac gtcttggcgg ctgatcatgc cgatgagttt ttggtggccg tcagtgacgg 2421721 gaagcacttc gatcccttcc cataccatca tttgcgcagc tgaagcgaca gatgttttcc 2421781 caataaccgt gacgggattt ttggtcatga ctttttctat agatgcattt cggtcatggc 2421841 cagcaatatc ttttgatgtc agaatgccat ggattttcat ttgatcgtcg acaaccggga 2421901 agcggccgtg ccccgtttca aaatttttct cataccattt ttcaagttta tccttaggcg 2421961 aaagatatac cgtgcggtca gcaggtgtta ggatgtcctc caccaaaaca atttcttttt 2422021 tgatcagctg gtcatatatt gcccggttaa tcatcgcggc aactgtaaag gtgtcatagc 2422081 tcgtggataa aatcggcagt tcaagctcat ctgccagctg cacaatgctg tcatccgtgt 2422141 taaagccccc ggtcaccaat acggccgcgc ccgcttcaag cgcctgcctg tgtgcattga 2422201 ttctgtttcc gacaatcaaa agattccccg ctgcggtgta acgcatcatc gcgtcaagct 2422261 ccatcgcgcc gatgacgaat ttattcaatg tcttatggag ccctgccctg cctccgagca 2422321 cttgtccgtc tataacattt acaacctctg cataggtaag cttttcaatg ttctcttttt 2422381 tcttttgttc aattctgatt gtgcccacac gttcaatcgt gctgacaaac cctttattct 2422441 ctgcttcctt gatcgctctg tacgcggttc cttcgcttac tttcatttcc tttgcaattc 2422501 ttcggacaga aattttttca ccgacaggca gtgaatcgat atacgttaaa atttgttcat 2422561 gcttcgttgc caagcctttc acctctaagg acagtcttct tgtttttatt ataaggtttc 2422621 aaaggattta tacgcaatga ggctggaaaa taaaaaagaa gcccgaccgg cttcttacag 2422681 cgttgatttc gttccagtca aacgcaagga ccacgtgatt ccttttacat cgtaaagcgg 2422741 aaaaaccttt atttttcttt taaatggaca tcaaccgctg tcttaacaat atttcgattc 2422801 cctattttag ataaaacaaa taaaactgcg gatagccata tcgcccctat ggccgtatag 2422861 atcaatggat gaacagctgt gtttgcgatc cattcattta ttaatgttct ggcatttacc 2422921 agaataataa atcctcctac aagcacaccc atcaattgcg gatgaaactt ctgcaccagc 2422981 catgctgcga taggggcagc gataattccg ccggccatta gtgaaaacac ccataaccaa 2423041 ttgacgtcct cccatcctaa tgaaataaga aaaccggcgg ttgcagatac ggcgatggca 2423101 aattcacttg tgtctacagt cccgacaact ttcctcgggc tcaagccttt gcgggataat 2423161 aaaatcggag tggtcaccgg tccccagccg cctccgcctg tggcatctgc aaaaccagcg 2423221 atcactccca atgggatgga ttgttttcgg tttaacggca catgcttctt ctcaagagcc 2423281 ggcttatatt gaaataaaaa cctgatcaat acatatccgc ccagaaggag caaaaacaaa 2423341 gaaatatagg gtttcgccac atctccaggt aattggctga ggaatgccgc gcctaaaaaa 2423401 gcgcctatag agccgggaat gacaagctga taaacggttt gtttgtcaac attgccaaat 2423461 ttaatatgcg acactcccga tgcggcagtc gttacgactt ccgctaaatg gacagaagcc 2423521 gaagccacag caggtgtgat gccaaacgcc aataacaaag aagttgaggt aaccccataa 2423581 gccataccta acgaaccgtc tattaactgc gacaataaac caataaatgc aaaaacgatt 2423641 aatttcttca tcagaacacc ccatctatat caatcagata tttttgactc ttcattcgaa 2423701 tctaacaatc tcttggcgct ttcatataaa aaataagagg ctttgataat tgcagtttca 2423761 tctattgtaa atgcagggtg gtgccaatca tgatcaccgt ctgttccaaa aaacgcaaag 2423821 gatcccggaa tatgctcaag ataataagca aaatcttccc ccgcggttga tggggcggga 2423881 tcaatgactt gaagtttcgc tttatgtgca gcgtctcgca ccagccccgt aattgcctca 2423941 tcattacaaa gcggcggcgg tccggaatgc cacttcacat ttgcctttaa cgagaaagcg 2424001 gcagaaatct gctctgtgac tgcaaaaaaa cgctgtttca cttgattacg aacctctgaa 2424061 tcaaatgtac gaacagtgcc ctcaatgacc actgtatccg gaatgacatt ccaagtgctg 2424121 ccgccgttga ttttccctac ggttaaaatc gcgctttgca gcgggtttac atttctgctt 2424181 acaatcgttt gcagggcgac aataagctga gaggcgccga taattggatc aaaaccatta 2424241 tgcggcaatg ctgcatgagc acctttccct tctatctcta ctttaaatcg gtcaacagca 2424301 gccataagcg ggcctgtttt taaccctaca gtcccaaccg cgatatccgg tttattgtga 2424361 aggccaataa ccgcatcaat gccatccagt tggccgtcct ctatcacttt tgtagcgcct 2424421 gcacccgctt cctctgctgg ctgaaataat aaacgaatct ttcctttcag actgtcttga 2424481 ttttccttca ataaaaaggc cgcaccaaga agcgctgccg tatgaaaatc atgaccgcac 2424541 gcatgcatga tccctttatg tttagacgca taaggcaatc ctgttttttc ttcaattggc 2424601 aaggcgtcaa tatcagccct caaagcaatc gccggacctt ctgactcccc tgctatgtct 2424661 gcgaacacac ccgtttttag agcagtaggg cgaatctgta tccccttttc tttaaggcat 2424721 ttttttataa aagcagttgt ttcaaattct tcttttgaca gttcaggata ttggtgcagg 2424781 tgccggcgaa tgccgatgag ctgcttttct agcgttgaga gatttacggg attagactcc 2424841 tctttcaacg tcaggatgtc atttcctgta gtctgatatg gataggagcc ttctatattt 2424901 ctccaataat ccaaagacat atgttccgct cctttcccta tcccaatata ttttcttcag 2424961 actcttcaac ataagatgaa ataaatcggt tcaatttatc agcaagaccg cccgccccaa 2425021 atcttatata cttgctggaa actttcggat tatcttcttt caaaaagctt aaaaaagata 2425081 aaatataaat gcgcctgtaa gctacttgtg taattccgta ctcaaaaaac cagttatcaa 2425141 tgacattgta tacgcctcgg ttgacgccat ataggttatt acatttcttg taaaagcaga 2425201 gatccggaag atttaactcc tgatgggaaa gaaggctttc ttttttgttt ggtgccataa 2425261 tcccaatcag ctcaaagcgt tttgcaacgc acgaaatatc ctttttaatt tgctttgtta 2425321 aagactccaa agaatcaaac cttctttctt ctctaatttt aaagagaatg ctgcattcga 2425381 ttttttctcc ataaatgtct ctatgaaagt caaacaaaaa aatctccaat gtcttttcaa 2425441 ggttagagcc caccgtcggt ttcacaccga tattcataac ccctaaatga aattgatgat 2425501 tgactgtcgc cagaacccca taaactccat tacgcagccc atgtattttt gcatctacat 2425561 ttgccgtggg gaatccaagc tttctgccta attgttttcc tttcacaacc gtaccggcaa 2425621 tgatcgtcaa aaaagtcagc ctcctctctc agcttccgca ttcgatcaga cgaaacctaa 2425681 tgatgtgatg aatgtaaaac ggattgatgc tgcggaatgc caagaccgag attttcccgc 2425741 aatgtcccgc cgcgataatc ttgacgataa agccctcttt cttgaagaat cggaatcacc 2425801 ttttctacaa aagcatcaag tgttcccggt atatccgacc caacgataaa cccatccgcc 2425861 gcctcagcgt tgaaccaagt ttcaattaag gatgcgacac gctctggtgt tccgatgaat 2425921 agagtccgtg gaaaagccat ttcctgtgct acctcccgca atgtcagatt tctggctttt 2425981 gcttctctct taatccggtc tgttgtgctt tgaaacgcat tctttcccac atcgccaata 2426041 tcgggaaatg gctcatccaa cgggtaaaca ctcagatcat aatcatcaaa aaaacgggcc 2426101 aaataagtaa cagcattttc aatcggtatc aattctgcaa attcacgata cttcttttcc 2426161 gcctcttctt ccgtatctgc cacaatcggg ctgatccctg gaaaaatccg cacacttgaa 2426221 ggatcacgcc cttcatcagc agctcggctt ttcacatccg cataaaacgc ttttgtctct 2426281 tctaatgaat tggaatgggt aaaaatcgca tccgcatttt tagcagcaaa ctgccggcct 2426341 gtttctgatg aacccgcttg aaacactaca ggctctccct gcttagagcg cccgatattc 2426401 aagggcccct ctacttgaaa atactttcct ttatgattca ggcgatgaag cttcgcctga 2426461 tcgaaaaact gccctgtttt cttattgtgt ataaatgcgt catgctccca ggaattccac 2426521 agcccgcgca caacatccaa atgctcttgt gcgatctcgt aacgttcagt gtgttctggc 2426581 aaattagact tactatggtt gcgcgccgct ccttcctgcg gcgaagtaac cagattccag 2426641 ccggccctgc ccccgctgat atggtccagc gacatcaatt gtctggagat agtgaatggc 2426701 tcagtaaaag atgtagagaa cgtccctact aaaccaatat ttttggtaac cgatgccagc 2426761 gcagataaaa tggtgatcgg ttcaaaacgg tttaaaaaat gaggaatcga tttttcagaa 2426821 ataaataagc cgtctgcaat gaaaataaaa ctaaacaaac ctttttcagc tgtttgcgcc 2426881 tttttcatgt aaaattcaat attcgtgctg gccgagggat caacatcggg atgacgccag 2426941 ccgtcagttg ttcccccgac accgtgaatc atggctccaa actgaataaa atctgcacgt 2427001 gtcatctttt tgcctccttt atctgtgcat gattagcaag tgcaagatca aggtgttcaa 2427061 tgccgatttc agttatccct tgatactgat tgccgcgccc gatttcgacc acaggcacat 2427121 ggcgcacccc atatttcacc tgtaaaatat cccgaagctt ttctttctct gaaacatcga 2427181 tattttggaa cgggaaccct ttttcattca aataattctt gacttcctca caatacgaac 2427241 agcctttttt actccaaacc acaatgttca caacatcact cattcttctg tccctcctta 2427301 acgttttgca gctaaaactg catcgctcag cagctgataa gacagctgtt tttctacagc 2427361 atttttgatc ggtgtaaaaa taacaaaatc attgattttg tatgtgcctg ataaacgtgt 2427421 taattcttct gccacttctt cctttgttcc ggcaataatc ccggtttttt gcacgatgat 2427481 gtcatagggc tctgtgacgt tttccagata ggcctcagcc tgttcgcggg aaccgacgtt 2427541 gaccttacgc ccgtctttca aaaccacttt tatcgattca cgcgacacaa tatgtttttc 2427601 cgcttcttct tttgtatgtg ccgcaaaaac agcgggggca agatgaaatt cagcctcaga 2427661 tcctggcggg agatgcgcgt caaatgctcg gcgggcttcc ttcagcactt cctcttcacc 2427721 gttaataaag taagcaaaga caaaagagat tcccagtttt gcagcagaaa tggcactctc 2427781 tgtgcttcct cccaatagaa aaatacccgg cttccgatca acctgcggcc taggacgcaa 2427841 tgcggcatag cggtgggtat caggaaaatc atcccgaacg aaatgagtaa gctcctccag 2427901 tttttcatca aactgacgca ccggtttttt atattcggcc tgcagcgcgt ctgtggacag 2427961 ctgaaacccg ccgggcgctt tgcccactcc aagatctata cggccgggag ctaacgctga 2428021 tagaagatgg aattgctccg ctactttata agagctgtaa tgctgcagca tcactccgcc 2428081 tgatgctaaa cgaatttttc ttgtgcttgc agcaagatag cctaaaagaa cctcgggtgc 2428141 agaccctgca atctcatcat tgttgtgatg ttcggccacc caaaatcggt gatatccaca 2428201 ttcttcagcc atttgtgcca atttcactgt atgctgtaat gtatcagctg ctgtctcccc 2428261 ttcaccaatc aagctttggt ctaaaatact taagcggatc atatcaccgg ctcctttatg 2428321 tgttcttttg gttcaaataa atattccggc gaaacacggc ggagaaactg cctcgttctg 2428381 tcttttttgg tatggcggaa gacttcctcc ggggttcctt gttcaacaat gactccttca 2428441 tccataaaaa caacttgatc agagaccctt cttgcaaact ccatttcatg tgtaacaaca 2428501 atcatggtgg ctccggtttt cacgatttcc agcattacct caagcacttc accgaccagc 2428561 tccgggtcaa gcgctgccgt cggctcatcg aacagcagca catcaggatg aatggcaagc 2428621 gcccttgcta tccctaccct ctgcttttgt cctcccgata actgactcgg ataagcgttc 2428681 aatttatctt gaagcccgac ctttctcagt tcattttccg ctacggcata cgcgtcttgt 2428741 tttctcattt tccgggcaat cgtcaagccc tccatgacat tttcaatcac cgttttgtga 2428801 gcaaacaggt ggtattgctg aaataccatt gccgtctgtt ttctgagcca gtgaacctct 2428861 tttttggacg gaaagcggca attaatcact ttgtcatgta tagaaatgat cccttcgtct 2428921 ggacgttcta ataaattcag gcaccgtaaa aaggtggttt tccctgatcc gctcggcccg 2428981 ataatcgtca caacttctcc cttgcgtacc gtgagattta tcccttttaa tacatggtgg 2429041 atgccaaact gtttatggat atttttaatc tcaatcataa agtgcctcct tgaaatctgg 2429101 ctgcctttct ctctaatact ccatttgcgg attctaggat tagagtcagc acccaataga 2429161 taatcgctgc tccgataaac gcttctaaaa atgcataatt atcagaagca acgatagtcg 2429221 ccgtccctgt aatctctggg acagccacta tagccgcgat agaggtggta tgcaaaaagc 2429281 cgatacccaa atttgtgaag tttgggatgg aaaccttcag cgcctgcggc aatattacac 2429341 gccgaaaggt ttggctgtat gtcaagccga ttgaataagc cgcttcgacc tgtccggtat 2429401 ccatcgccag aatgcccgac cggatgattt ctgtgagata agctccggca gttaaagaca 2429461 aggccatgat gacaaacatg gagaccggta tctcattagc ggaccagccg agatgaaaaa 2429521 aactgctgac ttgatctgca acaggcggta tccctaaata aatcaacata atgtgaagaa 2429581 ttgcaggtgt acttcgaaag aaagacacat aaaaccttga gcaagccacc aagcccttaa 2429641 ttctaaaaat tctaacaatt atatttccaa gagccacgag aaatccaaac acaatcggca 2429701 aaacagccat catcaatgtc agaggaatgg tctttaccat ttctttcatg gcggaaacga 2429761 taaatggaaa gtcaaattgc aatcttctcc cccctcatcc gaagaaatat atcaatgtat 2429821 gttcatgtca aaaacagtaa caatccttgt ttgattcttc ttgattcgtt tttctgccac 2429881 tcgaaagaac cattcgaata aaaccgctac agcataataa acaatcgata gcgcaatgta 2429941 aacttcaaga gaatggttgc ttgaggtaat cagtgtttgg ccccttccgg acatatccat 2430001 aacacctatt gaaaaggcta gagacgtatc ttttaaagaa ctgatcacca tgtttcccat 2430061 attcggaaac gcctggacaa gtgcctgggg cagaacgatt cgcctgaagg cctgactacc 2430121 gcttaagcca atactgtacg ccgcttccgt ttggccttta tctacactgc ccacccccgc 2430181 tcgaatgatt tctgcggctg ccgctgcatt gcttaacgcg taggttgcga cagcagcata 2430241 aaacgggtcc atttttgatg tatcaatccc gataagcccc gtaagcgccg ggatcccgta 2430301 aaacacgatg aaaagctgca ccatgatagg cgttcccctg aaaaacgaga tatacacttt 2430361 tgccaattga tttacaattg gaatattata gatgcggggc agtgccagaa agagtcctaa 2430421 tacaaaaccg aaaagcaagg acagtgttaa aatgtataat gtaaccggta aataagcggt 2430481 taacgtcggc acaaaatctc caatcatgtt catatcaaac gctttttcca tcactgctcc 2430541 ctctcttttt acctaatact gctctttgga atagtcgtca ccaagccatt tcaaactgag 2430601 ccttttcaac gttccgtcat caatgatttc ctgtaaggct ttatcaatat cgtcacttaa 2430661 cgtttgttca tttttgttaa acataaaata cactttggca tttgaaagca cattaccgac 2430721 ggttttttct ttaatagtgc tcgtcttgtt ttgaaagtct actgcaaaag gcgttgagat 2430781 cgttgcgtcc gcacgccccg atttcagctg attcgcagtc tcatttgcgc cttggccctc 2430841 ataggcaatc tcaaacggcc gtccattatc ctcattccat tttttcagta caagcgctcc 2430901 gttggaggtt gcactcgtaa tcacccgttt tccttttaag tcttcaattc cacggatcgt 2430961 atcgttattt tgaagcacag taatttttaa aggaaaatgg ttgtaagcaa ccttgttaaa 2431021 cagaaatttt ttctcacgct ctttgctttt ctccatttga tgtgccacga tatcgacttt 2431081 atgctgtccg aggctgacaa gcaggttgga aaattccatc gttttaaatg tgaatttata 2431141 atgtggcagg cgcttatcaa gctctttgat cagttcgaca tcataaccgg ttaaatcgcc 2431201 tttttcatcg ataaagcaaa tattcggaaa ttgggttcca gttccgaccg tgatcgtctg 2431261 taccttcttt tgcccggctc ccgtcgtttg actgcctgca ccgcaagctg acagaactgt 2431321 tataagcgaa aataatattg ccatgaatgc tgttttcgtt ttcatctcat cgccccattt 2431381 atttttcaaa acttgatttt gaataatctg ccccgagcca ttttcggctt agttttttta 2431441 gcgttccgtt tttctccagc tttttaatcg cttgatccgt gtcatccgcc aaggtttggc 2431501 tgcctttatt aaacataaag tacacctcgg tatctaataa cacgtcaccg actgtctttt 2431561 ggcggaaggc gtgcgtttta ttctgaaaat cgacggcaaa cggtgtagct atcgttgcat 2431621 ctgcgcgccc ggtttcaatt tgattggcgg tatcattgct tccctgtccc gcatatttca 2431681 aatgaattgg gctgccgtgc gttttgttgt actttgtaat ataatctgcc gcatttgacg 2431741 tggcgccaac tatgactgtt tttccgtgta agtcttttaa tgtatgaatc ttgtgattat 2431801 cctctttcac cgtgatgtac atcggcgagt agttatatgg gactttatga tacaaaaaac 2431861 gcttttctcg ttctttattt ttggccatat tgtgcgcaat cacatcaatt tttttatttc 2431921 cgagactcgt cagcaaattt gagaaatcca tcgttttaaa ttcaaatgta tattgaggca 2431981 actccttatc gatggctttc atcacttcaa tgtcataccc ggtcaattca cctttttcat 2432041 ttaaaaacgc aatattcgga aaatctgttc cagtgccgac tatgaccgtt tgagcctgac 2432101 gatctgtttt gttatttgtt tgcgaacatc ccccgccaag taatgcaaac actgacagca 2432161 gcaaaaccaa tcctttacgc ttattcatag gctgcctcac atcatgccca gctgggcgca 2432221 cctaaaagcg ttgggttaaa tcgttccgga atcagaacct tgtgcatcat cacacctatg 2432281 tccccgtctt tttcctgctc aaaatacact tcataccctc tccttctgta catgtcagca 2432341 agccaaggat gcttgcgcgc cgatgtgccg agtgtcagcg caggagcctt cagcatatct 2432401 cgaagcactt tttcttcaac atacgtaagc agcttacttc cggcgccttg ccctttatat 2432461 tccggcagtg tcgcaaacca ccacacaaat ggatattttg aaggaggcgt ctcactctcc 2432521 cacgggaacc tgattgtaat cgttgaaatc agcttcccat cccgctccag cacaatcgct 2432581 gaatgatgtt caatattttc tgataccatt tggatatcag ctctcgtgga tggccaatca 2432641 atatccagct gccgaatggg ctgaaatgcg ctgttaacca gtttcaacag ctccgatgca 2432701 tcttcaacag ttgccagtcg aaaaatatca tcactcattt ttgtcactcc tcttcacaaa 2432761 atatataatt cctatttgtt tactaagctt ttattgttta tactataaag catactctga 2432821 tctttgacta atcaaaaaaa gtaaaccttc acttcagtaa ttttaatgat gaaaaacagg 2432881 agggagcaca ttggagttac gctcaatcaa aacgtttcat acgattgtaa aatttggaag 2432941 cttctataaa gctgcagaaa tactcaacta ctcgcagccg acgatatcga tgcgtatgaa 2433001 gcaattggag caggatttag gcgtactgct gtttgaaaga ggaaaaagcc tgcagttgac 2433061 aaaagcaggg aagctttttt atgaacgaac aggagatctt ttgatgcaat acgaggcgct 2433121 taaacacaac ctctccgact taaaggaaga agaggcaggc attatcaaca taggggtttc 2433181 agagccaacc gccagtctga tattccccga gattttaaag gatttcttaa tggattaccc 2433241 aaagataacg gttaatatca aggttgatga cgccaatacc tgcagtcaaa agctcttaga 2433301 cgggacgatt gattttgcag tctgcggcga gccggagctg attcttgaaa attactacca 2433361 tccatttttt tatgacacat taaatgtgat tgtatctgat caacatccgc tcgctgagaa 2433421 gaaggctgtc catttgtctg atttagcaga agagcgcttc atatttacgc ccgccaattg 2433481 ccccattcgc ttacaaattg aacagcattt acatagagaa ctcgggaatc gctacaaaaa 2433541 aatggagctc acaagcagca tgtcacatga atattacgta cgtgaaaaca tcggaatttc 2433601 aatctttacc agcaccgcac attctaaacc gttcaacggc actaaagtca ttccaattct 2433661 gaacctggat atcaccccgc ccatagggct gttgacaaat caaaaagaag ttcattttga 2433721 ccgcgccacg aaggacttga tcgcccggat aaccaaacgt tttcagcagc gcagcaaaga 2433781 attggaagga acctctgata agaccattac aggataactg aaaaaataaa aaccacctcc 2433841 tgattcatca ggagatggtt tcacggttta aagctcgatc gtctcaccga ccgacatgac 2433901 tttgccgact ccgcccggca ggctgtcagc gaatgcttct gggtcttgtt cgatgaccgg 2433961 gaatgtattg taatgcaccg gcacgacctg ttttgcgcgc agccattcag cagcaagctt 2434021 ggcgtcttca ggccccattg taaagttatc gccaatcgga aggaaagcaa ggtcgatatg 2434081 attcaattcg ccaatgagtt tcatatcaga gaaaagtgcc gtatcgcccg cgtggaaaat 2434141 cgttttatct tctacagtca gcaaaatacc ggcaggcatg cctgtgtaag tgatcgtttt 2434201 gttttcttca tctgtgatgg ctgatccatg aaaggcctgt gtgagcttca cttttccaaa 2434261 atcgaactgg cgggagccgc caatatgcat tggatgaaca ttcaagcctt tccagcctaa 2434321 gtacacagcg agctcgttcg gggctataac cagcgcgtta ttttgcttgg cgatttgttc 2434381 agtatcaccg acatggtcat tgtggccgtg cgttagtaag atgacatccg cttttacatc 2434441 ctccggcttt atatccgtta atgaattccc tgttaaaaac ggatcaaaaa taatatgatg 2434501 gtccttcgtt tccactgtga ttacagaatg tccgtgatat gtcactttca tttctttcac 2434561 ctcgtcacat gattttgttt tttttatttt ccctttttaa aaagctgaaa aacttatgtt 2434621 gtttgattct tgttaatgac attgaggcct ccggtggctt caatgacagt ccctgtcaca 2434681 aggtctgagt tctcctcaca caagaaagcg ataatcctgg caatatcctc gcctgtaccg 2434741 gatcttccta tcggcgtttt ttctttgccg attcgcattc tggcttcctc tatcgatgct 2434801 tctttcatgt cgccgacaat gtctcctggg caaaccatgt tggcggttat gccgaattcg 2434861 gcttcttcaa tggcaattgt cttcgtcaaa gaagccaagc ccactttcgc agcgccaaat 2434921 gccgatcggt gaagccagcc gggcgcgtga gccgcacctt ggaatccgta cgtaataatg 2434981 cgtccaaatt gctgttttct cataatagga ataaccgctt tgaataaatg aaagacggcg 2435041 cttaaatttc cttccagcat gccataccat tcatcatcag tataatcggc taacttttta 2435101 cgttcaaata tgtatggtcc agcgttgtta atcaaaaagt cgatccttcc gaagcggttt 2435161 aaggcagcct ctgcaatacg cagcagatct tcttttttgg tgacatcacc ttttacaaat 2435221 tgcagccggt caagacaatc gggacaggct tccttcaggc ggctgactgc ctcctcatcc 2435281 tgtctgtaat tgactgttac tgaatacccc tttgcaagca acgtttcagt cactttgcgg 2435341 cctaaaccct tcgaaccggc agtaattaaa gcatgtcgca catgaatacc tcccaaagca 2435401 acgtcgccgc tttcaataaa gtgtttcttc ttctacttta ctataaaagg cttgcaatat 2435461 cactttttac actttggcat acaaaaaaag ctgcctgtac agacagctta ttctgcagga 2435521 gatgaagact cctgatcagg catatcgaca taaccgcttt gatatgcttc tgaaatgagc 2435581 cttgttgtct cctggctttc ttgttcatca taaatatagc gttccggttc ttttttcatc 2435641 attctgcctc ccatcattat agaggtaggt tggctataat gacgggattt tatgaaggaa 2435701 attttaacaa actcctgctg ccacgcaagc tttcgctttt tcaagcgcct gttccacctg 2435761 tttgaatccg gtgcccccgg cgctcattct tttttcaact gcgtagtaag ggtctaacac 2435821 agtgtaaata tcttcttcaa atagtgtgct cgcctgctga aactcgccaa acggcatatc 2435881 gcttaaatag atccctcttt cgatgcatgt gtacacaagt ttcccgacca cttcatgcgc 2435941 ttctctgaac ggcattcctt ttttagctaa ataatcggcc agttccgtcg cgtttgaaaa 2436001 gtcttgtttt gttgcttgct tcatgacgtc tttgtttaca gtcattgttt ggatcatgcc 2436061 tgtgaagatt tgcaggctgc cctccaccgt tttcaccgtg tcaaacatgc cctctttgtc 2436121 ttcctgcaga tctttgttgt aagcgagcgg aagtcctttc atgatcgtaa acagccccat 2436181 catatcgccg tatacgcgtc ctgttttgcc gcggatcagc tccgccatat cagggttttt 2436241 cttttgcggc atcatgctgc ttcctgttgc gtacgtatcg tcaagctcga tgaatttaaa 2436301 ctcctgcgag caccataaaa tgatttcttc agagaaacgg gataggtgca tcatcagcat 2436361 actgctgttg cttaaaaact ccaaaatgaa gtctctgtcg ctgacgccgt ccaagctgtt 2436421 ttcataaatg gcatcaaagc cgagcagttc cgctgaataa tcacggtcaa ttgggaaggt 2436481 tgttcccgcg agcgccccgc agccgagcgg agatttgtta atccgcttca ttgaatcctg 2436541 aaaacgctcc ttgtcgcgct caagcatcca gaaatacgca agcagatggt gagcgaatga 2436601 aatcggctgg gcgcgctgca aatgtgtgta gcccggcaga atcgtttcaa cgttcgcttc 2436661 cgccttttca atcagcgcac tttggaatgc ctcaatcagc tcgatgatgt ggccgacatg 2436721 attcttcaag tataaatgca tgtcagtcgc cacctggtca ttccggcttc tgccggtatg 2436781 cagcttgccg ccaagaggac cgatttcgtc aatgagcatt ttctcaatgt tcaaatgaat 2436841 atcctcataa tcgactgaga attccaatgc tccctcctct gctttttgca aaagggtatt 2436901 caggccctct cggattttca actcttcttc tgctgtcaga ataccgcatt ttttcagcat 2436961 ggcagcatgt gcgagagacc ctgtaatgtc ttcagcaact aaattttggt caaatgatat 2437021 ggacgcgccg aactcgtcga cccatttttc cggtgttttt tgaaatcggc ctccccaaag 2437081 cttcttcatg ctttaatctg ctccttcttt ttcacgatgc tgttcacttt tgtcggaagt 2437141 ccccaaagct cgataaatcc gattgctgca tggtgatcaa atgcatcgtc ttttgtatat 2437201 gttgcaagtt tttcatcata tagagagtat tccgatttac gtccttctac aattgcatgg 2437261 cctttaaaca gcttcacgcg gacaatgcct gtgacatgct tttgcgtttc ttttaagaaa 2437321 gcgtgcagcg cgtcttttaa cggtgagaac cataagccgt tgtaaatgat ttctgacatt 2437381 ttttgctcga tgatcggttt aaagtgggct acctctttca ccagtgtcaa atcttctaat 2437441 tctttatgcg ctttgatcag tgtcatcgca ccagggcatt cgtatacttc ccgggattta 2437501 atgccgacga ggcggttttc cacgtggtcg atacgtccga caccgtgcgc gcccgccatt 2437561 tcattcagct tcaagatcag ctcagaaagc gagtaggaaa caccgtcaat ggagacaggc 2437621 acgccctgtt caaatgcaat ttcaatcact tccggcgtgt ccggcgtttt ttccagcgga 2437681 gctgttaaat cgtatgcacc ttctggcggc gccgcccatg gatcttctaa aatgccgcac 2437741 tcattggcgc gtccccagag gttttggtcg atagaatacg ggctgtcaag attgatcgga 2437801 atcggaatgc cgcggctagc cgcatattca atttcttctt cacgtgacca ctgccattcg 2437861 cgaaccggcg cgatgacttc taggtcaggg tttaatgatt taatggagac ttcgaaacga 2437921 acctggtcat ttcctttccc tgtgcatccg tgggcaatcg cctgtgcatc ttctttttcc 2437981 gcaatttcaa ccagtttttt cgcgatcagc ggtcgagata atgccgaaac aagcgggtat 2438041 tttccttcat acattgtgtg ggcctgcaaa gagataagcg cgtaatcctg tgcaaattct 2438101 tcttttgcat cgatcacgta ggagtttgtc gcgccgactt caagcgcttt ctgctgaaca 2438161 aatgccaaat ctttgccctc accgacatcc aggcagcagg cgattacatt atatccttgc 2438221 tcctgaagcc attttattgc gacggaagta tcaagacctc ctgagtatgc taatacgact 2438281 tttttctgtt ctgacatgat aaaaatcccc tctcaaccgt gtttctattt tgtataaaaa 2438341 taaattatat ttaataaaaa tacattttgt atgtatacac tttaacaagt acgtttcgtt 2438401 ttttcaagcc ttttataaaa aaaacttcac ctaaatttca ggtgaagttt catagtattt 2438461 attcatttac ttgtcttttc tgatttctct gaccacatgc gcaagttcgg gaataatcag 2438521 cttattcatt gccagcttta ctgcgccgct tgagcctggc gttgagaaaa cagcggtatg 2438581 ctgaatgacg ccggcagttg ctctcgacat gattgcggca gagccgatat cctctgtata 2438641 actcagcatc ctgaatattt ctccaaagcc gggcagttct ttcgaaaaca gcggcgttat 2438701 ggcttcaatt gtgacatccc gatctgctat gcctgtccct ccgtttaaga gtaccgcgtc 2438761 tgtctgttca tccatgcagc ccgcaagcac tgaccgttgc aaagcatcct tttcgtcttt 2438821 tacaatttca tatgcggcaa tatgatgacc ggcttcttct aaaaatgaga tcatcagctt 2438881 gccgctttta tcggtttcat ctgtcctcgt gtcactgaca gtaatcactt tgcaccgaac 2438941 gatatcggga gcttcttgtt tatgctcttg aacgctcatt ggcccacctc ttttatgttt 2439001 tctgtctgtc actatcatgc atcaacaaaa aagcacattc aagagaatgt gctttcatgc 2439061 gatttatttt gctaaacgaa caacgtcgcg cgcaatcatg acttcttcat cagtcgggat 2439121 gatcatgact tttactggag aatgcggata gctgatgaaa gcttcctcgc cgcgcacgtt 2439181 attaagcgca gggtcccagt atacgcccat gaattctaaa ccgcgaagaa cgcgttctct 2439241 gacttccaca ctgttttcac cgataccggc agtaaagatg atcgcatcta caccgctcat 2439301 tcttgcagcg taagaaccga tgtatttgtg gattctgctt gcgaatactt caagagccgt 2439361 ttccgcgcgc tcatttcctt ctttcgtagc ttcaacgatg tcacgaagat cgcttgagaa 2439421 accggaaatg ccgagcagtc cgcttttttt gtttaatgta ttcagtactt cgtcagccgt 2439481 ttggcctgtt ttctccatga tgtatgggat cagggcaggg tcgatgtttc cagagcgtgt 2439541 gcccattgct acaccggcaa gcggcgtaaa gcccatggat gtgtcaatag attttccgcc 2439601 ttcaacagcg gcaatacttg ctccgtttcc aaggtggcag gaaatcaggc gcaagtcttt 2439661 taacggacgg ccgagaagct ctgccgcacg ctcagttaca tatttatgtg aagtgccgtg 2439721 gaagccgtat ttacggatgc cgaatttttc atagtattca tacggcaagc tgtaaaggta 2439781 agactgctca ggcattgttt ggtggaatgc tgtatcaaat acagctaccg caggaacatt 2439841 tggaagcact tctttgaacg ctttaattcc aacgatattt gccggattgt gaagcggtgc 2439901 caattcagaa atatcttcga tttccttaat ggtttcatcc gttaataaaa cagaatcgct 2439961 gaatttttct ccgccgtgaa cgacacgatg gccaattccg tcaatttcat tcaagtcttt 2440021 aataatgccg aattccgtta acttattcag cagcatttta acagctaccg catgatctgg 2440081 aatatcagtt acttctgtat ttttttcgcc gttcacagaa attgtgaata cgctgtcggc 2440141 gataccgatt cgttcaacta aacccttcgt taaaacggtt tctgaaggca tttcgaaaag 2440201 ctgaaatttc aaagacgagc ttcctgcgtt aattgcaata attttggaca tgattgacgc 2440261 tcctttatac tctgtatcaa caacttcgtt tttcgtactt ttttcccggt gaatatcaac 2440321 atcttctccg aaaaatatct gacttttcca tttaaacatt gtcatgtcgg cttttcaagt 2440381 caacttgcgt attgataacg cttacaataa gaagtcgtta ttttcagaca cattcactat 2440441 aggttttgta ttgatgaacg cttacaattt gcggtttttc cctctgtatt ttgtgtttca 2440501 aagctggatt caattcgtca agtccggtct tcaaaagcat aaataaaagc agcttaggca 2440561 tcgacctcat acggctgtct aagctgcttt taaaacactt acttttcttt tttaaaccat 2440621 tcatcaaatt gagccatcat atcaagcatc gccttttgat tggagaaaga cggaagattc 2440681 gcaagcagaa tttgccccgg cgctttcgta ttctctcctt gtttctgaag cacaaggatg 2440741 cttttggcat gagcttcgtc tttaaaaata gattttggca gctgcaacag tgcgttgata 2440801 tgaaccttat ctttgaaaaa ctgtttcagc ttgccgcttt gggagctctc aaacaaatga 2440861 ttcggaatca taaaaaataa gtagccgccc ggtttggtat gcttgacgct ctgttcaata 2440921 aacagatgat gagcgaagga atggccttcg tcagctttga gctcaaacgc ttctgctcct 2440981 tcgtcattcg gataatagcc gactggcaga tcacaaatga ccgtgtcaac tggatcgata 2441041 aacaacggct caaggctgtc ctggtggaaa agctcaagct cttttttcag aaggttcgct 2441101 tgggcatagg cgatcttcaa gagcacatca tcaatttcaa tgccaaagct gtttgccgtt 2441161 ttttcagaca gctggttcag cacggtaaac agaaggttcc cagttcccag ggctggatca 2441221 agaatggtca gttccttttt gtccgccata aatttattca ccaaatagct gatgaaaagc 2441281 ccgatcgtat ccggcgtcat ttgtctgttt ggatgcgaga tatctttcat tcctttaagg 2441341 acggcaagct gaaaagcctt gcgtacccac tcatgctcat acgtgccgaa ttccgctttt 2441401 tcaagcagag cctgaagttg tttggttttc tgatcagcag gcagtttcag ctgatccgtt 2441461 ttttcaagaa aatacatttc tcctgcttcg gccagcgcct ctatatatga aatctgcaat 2441521 tcattcttta tcataatcgc ggcttcgttt aacagctcat acaccgcacc tacatggtct 2441581 ttttgcatat tgtgttcctc cttgccatga aaaaagctcc ggcggcagcc tggagctttt 2441641 ttccctgctt actttactaa tgccttagca gcctcaattg gcttttcata gttcgggtgg 2441701 tttgttgctt cgcttacata ttcagcgtaa acgacttttc cgttctcatc aaggacaaat 2441761 acggaacgcg caagcagacg aagttcttta atatacacac cgaacgcttc gccaaatgac 2441821 atatctctgt ggtcagacag tgtttccact ttgtcaattc cgttagcgcc gcaccagcgc 2441881 gcttgcgcga atggaaggtc tgcactgatt gtgtagacgt tgacatctcc aagctttgca 2441941 gcttcttcgt taaaacggcg tgtttgtgca tcacaaacac ctgtatcaat tgaagggata 2442001 acagaaataa tcgttacctt tcctttcatg tcagctaacg atttttcttc aaggctgtta 2442061 gtcagcactg tgaaatcagg agcttgatct cctaccttca cttcttgtcc gacaagtgta 2442121 accggaccgc ctttgaatgt aatttcagcc attataattc ctcccttttg tatgtatgtc 2442181 tctatcatag taaagtttcc tgcaaactgc aaagtttatg ccaaaaaaaa gttaactgcg 2442241 gccagcgcag ttaacctttt tttaataatt catattgttc atttggtttt gattttggcc 2442301 ttggctttgg tttttgttat ttttcttgaa catttgctgg atgcgctcga gtgtttgagg 2442361 ggctgcgtct aaaattttct ctattaaatg ggtattttca tctaaatgaa gcattctgat 2442421 gcctgtcgat ccgacaatta aaaacgcgat cggcgtaatg gacacaccgc ccccgcttcc 2442481 gcctccgaaa ggaagtttct gttctcttgt ctcatcgtct tccgatttct tttcggccgg 2442541 ctttccgcca aactcgcttc cgcctgcggc gaatccgaat ccaactttag aaacagttaa 2442601 aatcacactt ccatcaggcg tttccactgg atctccgatg atggtgttaa catcaatcat 2442661 ttccttcaag ttttccattg cggttttcat taaaccttgg atgggatggt ctgccatata 2442721 cgcttcctcc ttaaactgat gaatcattct ttgaagtcat tctagccgac ggattcttct 2442781 ttaatacgga tagctcccgt ccgtatttga cgaatttgaa agctgcaagc atagcatgtc 2442841 caaagcgaaa aaagaatata cactgaaaat gggtcttgga aacagggact tgaaacgacg 2442901 ggatcacctc atagacaggt ttattcacaa agtccaggtg gtcgtagagc attgctgcga 2442961 taccgccctt cacgccccat acagcaccgg ttaacacacc tgtcactgcc gcgtcctgaa 2443021 ttccgattac tgtaacccat tctagttttg tgatatgtaa atgcgcgaga aaagacgcgc 2443081 tgattttccg cagtctggtg acctgatgca aaagcatttc gattttatta atgctttgct 2443141 gcacatcgtt ttgtgtaatt tttttctttc cgctgctttt tttcattttg gattcagttt 2443201 tttgtttgat atccactgtt ccgtcttctt tgttcacctt aatcgccggg attgtttttt 2443261 tgatccttat aaggccaaac agcgccgtaa tcttcaaggt caatttgtca ttatcatcgg 2443321 catgaagata ctccagcgcg acatggattt tcattctgag aagcagtacg atccctatga 2443381 gaataagaat ggctgtcagt acatacacca tattcttcac ttcctctagg agcattatcg 2443441 ccaattccta aaaaaataaa cccggacgga agtccgggtt atcggttatt tgcggtataa 2443501 tttttcatgc accacggtgg tatccgcgat gtaatcatga atcccttgtt ttgtaggtga 2443561 aaaggcaaca acgatatata aaatccaaat cttatcaata taccgtccaa ccacttcacg 2443621 aaaaatcact gtactccatg tcagcttgct atcttgcttc acagaaacca ctttgaggcc 2443681 gaacaccatt ttaccaagcg tctgcctgaa gtattttgtc atgagtgcga aataggcaag 2443741 atacacaata agcgttgtca cactgtaggc cgagaaggta aacatgccgg atgttttcgg 2443801 cagatccaat acggtaaaga ggggagaaac gagcaaatgg tttaatcccc atatcacgag 2443861 ccaatcaagc aggaaagccc agaaacgaac ccaaaagcca gcataggcat gtgtcagcag 2443921 ctccgcttct tgcgggcctt tgatgtcatt gcgctctaac tcttcatatg tcgcgtccat 2443981 tattgttccc tcctacttcg catagagata catcattctc ggcgaaccgg attgcgatag 2444041 aatttctctc atattcaaaa aatcaatttc acttttaaac attttgttcg cgcccatgga 2444101 aaacagtgag cctaatccga agctttcctc ataagaaatg acagaggcgt ttttcaaatc 2444161 cttgtgatcc tttttcatgg ccgtaatggt atcgtcataa aaaccaagct catcaacgag 2444221 gttcagtttt ttcgcctgcc gtccgtcata cacgcggccg tccgcaattt tctttacctc 2444281 tgctttcggc atgccgcgcc cttttgaaat gacatcaaca aagccttcat acgaattatc 2444341 aaccatcgat tgcatgatgt ttttttcttc tttcgtcatc tcacgggaag gagacataat 2444401 gtccttatgg gccccgctct taatcgtttc aaaagaaatg ccaagcttgt cggcaagctt 2444461 tgaataattg acgctttcca taatgacgcc gagtgacccg gtcagggttt ccggtgtcgc 2444521 aaaaatctta tcagccgctg ttgagatgta atagcctcct gatgctgcca tcgaacccat 2444581 tgacacgtaa atcggttttt tcgtttcttt cttgatttct tccagtttct tatgtatttc 2444641 agcactttca tacactccgc cacccggaga attcaccttc agaacgatac ctttgaccgt 2444701 cttgtcatct tttgcgcgct caaggttttt taagaacgtt ctgtggttat atccgtctgc 2444761 accaagcaga ctgcttgagt ccccattatc ctgaatggtg ccgctgacct ctaatacggc 2444821 aattttactt gagggactgc cgttttccag cgtcttctcc tgcgattcat ccgtcagtga 2444881 tgtgagatcc gtttgagcgc ctttgacgct ttcaaagaaa ctcatagaga tgctgacgat 2444941 aatagacacg ccgaaaatcc ccagagcaat cactaatgca atccatcttt ttgcattcat 2445001 tttttctcct cctttttcct aaactctctc attatacgat tcaatatgaa aaatgtttca 2445061 cttcatgaga aagctccggc ttaacgggct gccggcaaac gtggtacact tatggccaaa 2445121 ggtattttat cacaaatact ggatggcaga aaaacttaaa tatgacagca aaggggaaat 2445181 gggatatgac cgatcaacgc cgtaatgttt atttttttca caaacaggat caggaaacga 2445241 acgaacaagc ccgctcgtta acacaattag cggaagagca tggatttacc gttgtgaacc 2445301 agcactcaga cgccaatatt atcgctagca ttggcgggga cggcacattt ttgcaggcag 2445361 tcagaaagac gaattttcgt gacgactgct tgtacgtcgg cattaccaaa aaggggaaag 2445421 ctcatttata ttgcgacttt catagtgatg agcgagaaaa aatggtcgat gcaatgacgt 2445481 ttgaacaaat tgaagtgaga aaatacccgc tgattgaagt gacagtggat caagccagtc 2445541 cttttcactg cttaaacgag gtatccatcc gctcaagcat catcaaaacc tttgtgatgg 2445601 acgtgctgat tgacgatctg cactttgaaa cgtttagagg tgacggaatg attatctcaa 2445661 cgcctacagg gagcaccgcc tataacaagt ctgttgcagg agctgttgtt gatccattgc 2445721 ttccatgcat gcaggtatca gagcttgcat cccttaacaa taatacctac cggacactcg 2445781 gctcgccatt tgtcctcagc tctgaccgaa agctgaccct tcgtgtggtg caggacggca 2445841 acgaacaccc aatcatcggc ttggacaatg aagcactcag cacgagaaat gtgaaaacga 2445901 tcgaaatcaa actgtctaat aagaaaatca aaacagtcaa actaaaggac aattcatttt 2445961 gggaaaaagt gaagcgtact tttttataga aaataaaagg acaggctgct gcctgtcctt 2446021 ttatgatttc tcatatacaa tctggccgtt aatcacggtt tttttaatct ctaaaagatg 2446081 aagctgtgcg gggtcaatgg caaacggatc accactgaga actgtaaaat ccgcgtcata 2446141 gccttccgca atttttccgc gtgacttctc tttataaatg ataccggcgc taccttctgt 2446201 ataaagcttt atcgcttcat atacaggtaa acattcactt tcattatagc ttggcccgtt 2446261 ttgctcatga ctgcttttcc ggaggaccgc ggactggatc cctagaagcg ggtcaacagg 2446321 ctcaatcggg gcgtctgaac cgcccgcgca taaaatgcct ttagatatga gggttttcca 2446381 ggcaaatgca gtcttcatcc ggtcttttcc gagacggtca atgacccacg gaaagtcgct 2446441 tgcaacgaag tgcggctgaa ggtcaagtgc gatcggcatg cgtgctgctc tctcgattaa 2446501 ttcgttatca agcacttgag catgaataag ccgatcatgc cggccgtttt tgggcggatg 2446561 cttttctatt gcgttcagca ctttttcaaa agcaagatcg ccgattgcat gaacagcaac 2446621 ctccatccct ttttctctcg ctttgcgaat gagccggcca agggtttcgt catcgtgaac 2446681 ctgaacacca tttgttgatg gatcatcctg atatggttct ttcaataaag ccgttctccc 2446741 gccaagcgcc ccgtccgcaa agattttcat agcaccgaac tccacatacg ggccggacag 2446801 cttctccagc tgctcccatc gatcgacagc ttcatgatga acgagcaaat ggcagcgaaa 2446861 cggatacttt ccgccagcgg cagctttctc ataagctttc atcggcaccg aaacatcacc 2446921 ataataggac aagtcttccg aatgaccgcc cgtcaggcct tttgtccagc aatcctttat 2446981 tgcagccgtt aatgcctcat caacatagtg ctgggagact ggcgggacag ccttcagaat 2447041 caaatcctgc gccttatcaa acaggagtcc ggtcggctcg ccatttgcat cttttacgat 2447101 gactccgccg tcaggatcag gagtatttct tgaaattccc gctgcttgaa gagccgcaga 2447161 attgacagct attgcatgcc ggcatatacg cttgagcaag acgggcctgt caggaaacag 2447221 gcgatcaaga tcatgcttag tcaagtagtc aggtgtctca aactgatttt cattccagcc 2447281 ttctccaatg agccaatcgt ttttaggaag ctgccgctct ctttccttcg cagcctgtaa 2447341 aattgaatct ttcgacgtca gtgcggacag atcgagctga agctgtttct caccgtggcc 2447401 gatcaaatgt agatggctgt caacaaaacc ggggaacatc actgctccgt tcaggctgat 2447461 ttcttctgtt tccggcgacc cgtacttttc cttcaaacgt tcatagctgc cggtgccttt 2447521 tataacacca tcctcaacat aaactgcctc agtccgatcg ccttcttcga gcatcgtata 2447581 aatgaaaccg ccgtgccata tcgccttcat tcacgttcac tctctttctt tacgcctttt 2447641 tattggcttt gagctgttct tcacgttttc ttaattccac tcgtctgatt tttgcagaag 2447701 ccgttttcgg caggctttcc acaaattcaa tttctctagg atatttgtat ggagcggtaa 2447761 tcgtcttcac atggttttgc agcattttga caagctcatc actgcgtttt tcatgatttt 2447821 gcaggacaac atatgccttt acgatggagc ctctgatttc atcagggctt gcgacaacag 2447881 cacattcttt tacttctggg tgcttaacaa gcgcgtcttc cacctcgaaa ggcccgatcg 2447941 tatagccgga gctgataata atatcgtcat ttcggctttc aaaccagaag taaccttcct 2448001 catcttttct tgctctgtct cccgttagga aataatcgcc gcgaatttgt gttttcattc 2448061 tttccggatc tttaaaatac tctttaaaga gcgcaggcgt actgaggtga acagcgatat 2448121 cgccaacctc accaggtttg cagatttcac cgtcttcatt tatgatctcc acctgatttc 2448181 ccggtgtcgg ttttcccatg cttcccggtt taataggcgt atctttcaaa acaccaacca 2448241 aaagcgtgct ttctgtttgg ccatatccgt cccgtacctt aatgccaaag tgcttttgga 2448301 aaacatcaat gacttcacgg ttgagcggct cacctgcgga aacagcgctg tgcagggcag 2448361 aaagatcaaa gcgtttcaag ccttcaacct tcgccattaa gcggtattct gtcggagtgc 2448421 agcagaaaac attgattttg tagcgattta aaagctctag atatttttct gctttgaatc 2448481 tgccgtggta cacaaaaccg gttgctccgc tgccaagcac cgctaaaaac ggactccata 2448541 cccacttttg ccagccaggg gcagcagttg cccagacgat atccttttca gaaatgtcaa 2448601 gccaagcgcc ggcagaagtt tttaaatgag caaatgccca tccatgtgta tgtacaacac 2448661 ctttcggctg acctgttgtc ccggatgtat aagataagaa agccatatca tctcttgttg 2448721 tgtcagctgt tttaaattgg cttccgtccg cttcaattga taagaggttt ttccagccgg 2448781 catcattttc accaatagac agtgtaatca gtttgtcagc cgtactgaca tcccggaaag 2448841 cgccaataaa ttcggagtag acgatagcgc cttttacctc tgcatgttca atccggtatt 2448901 caagatcttt cgcgcgaagc atttcggagc acggaatgac aaccattcct gatttcagga 2448961 tagccaaata aacagcatag gcttcaagca cccgcggaac cattacaatc agcttgtctc 2449021 cctttttaaa tccaagatca gctaaggccg ctccgatttt atttgtttct tccatcagct 2449081 tttcatacga ccaagattct tgcttgcccg actcgtcctc ccaaagaaga gcggtttttt 2449141 gtccagcagc actgaacttt tccatttcat tcactaaatt atattgcaca ggggcaatta 2449201 aatcttcacg ttttaacacg aacaactcct cactttctcc acccattata cataaataca 2449261 ggctctttcc gtaaggatat gcctaaaagc aacctctgta aacatagatt ttataggccg 2449321 ctggtccttt tttatatgta aaaaatgaaa aagagtgggg atacccccac tcctaagcca 2449381 ttatgtgaaa ttgtaaatta gaattgtcct ccgcccatgt tttgttgagc aaaagataca 2449441 agacgttttg tgatctctcc tccaacagaa ccgttagcgc gagaagttgt gtctgctcca 2449501 aggtttacac cgaattcaga agcgatttct aatttcattt ggtcgatcgc ttgagcagct 2449561 cctggtacta aaaggttgtt gctgttacct gagttattgt tagccatgtg tctcacctcc 2449621 ttgtgagtat agaatgtgtc aaaacacatg gcttcattca gaaaaacttt ggtaattgta 2449681 tacaggagct gaaaattgat ttaaaagagt tcagcgaatt tatcgttagc ttcttgttcg 2449741 ctataaaggg tcattgtctc aatgttatct accgcttctt gaatatacgg ctcgaaatca 2449801 acaaagcttt caaagtgttc aattttctct tttttagggc gtgttttcgg gcttggcggt 2449861 gtaaagatcg tgcagcagtc ttcaaacggc tgaatacttg tctcatatgt gccaatttcc 2449921 cgtgattttt cgatgatttc tgttttgtcc atggcgatta gcggacgcaa aatcggtgtt 2449981 gacgtcaccg cattaattgc atacatgctt tcaagcgttt ggctcgctac ctgaccgagg 2450041 ctttctcccg taataatggc aagcccgttt ctcttttctc tgattctgtc ggctatctga 2450101 agcatgaggc ggcgggttgc cgtcattgtg taattttcag gaatttgttt ttggatgagc 2450161 tcttgcgttt ttgtaaatgg aacaatatga agtgtcatgc ttcccccaaa acgggacaga 2450221 catttcgcca gatccattac cttttgcttt gcgcgctcgc ttgtgtatgg cgggctgaag 2450281 aaatgaacag cttctaccga caatccccgt ttcatcgcat aaaaaccggc cacagggctg 2450341 tcaaaaccgc cagaaagcat cagcatcgct tttcctgctg aaccaactgg cagcccgcct 2450401 gcaccttttt catcacgaat tgtcaaaaat gttgcttctt ccctgatttc gattctgagc 2450461 gggatgtctg ggttgcgaac atcgaccgtc aatccttctg tatttcgcaa aatatggccg 2450521 ccgatttcag cgttcatctg gtttgtatct aattcaaatt gcttatacgc tctctttgtc 2450581 gcgactttaa acgtatcacc tggtttatac tgatctttga tagcctttag tgcggttgcc 2450641 ttaatatcat caaggcggct gtcacactta attgccaggc tgaagctttg aatcccaaac 2450701 acttgcttta aatgaggaaa aagagcctca ggatcctctc catttaatgt aatcgtcata 2450761 cgatccctgt tggaaaagta ttttaaattc ggatagtctt tcaaaacgag tctgatgttt 2450821 tgttttaagc gctcaataaa gctttttctg tttttgcctt tggtcgaaat ttccccaaaa 2450881 cgaattaata tatgatcgta attcatgttc tacctcatca tttcccttaa ttttttgatg 2450941 ccaggacgaa gcgcgttcat aaacggttct gccacatcgc ttgtctggct gtaatttaaa 2451001 ctgattctga tgctgcttcc ggcaatctgc tctcctttgc ccatctctaa gagaaccttg 2451061 ctgggcttat gttcttttgc cgagcaagcc gatgttgtgg agacgaatat atcctgttcc 2451121 tcaagcatgt gtaaaagcac ttccgcttta atccccggta cagagaaatt aataatgtgc 2451181 ggcgcgctat tcatttgagg cgtgttgata acgacgccct caatttcact cagcctattc 2451241 ataaacaatt cctttacggc agtcatcgtg tcaagccgtg tgtcaaaatc agcagaggcc 2451301 agattaatgg ccttggcaag cgaaaccgca ccagcagtat gttctgttcc ggcccgtatg 2451361 cctttttgct gagagcctcc cgttatgagc ggaataaggc gtgttccttc ttttacaata 2451421 agtgcgcctg tcccctttag gccgtgaaat ttatgccccg aaattgaaca tagatcaatg 2451481 ccggcctttt caattgccaa gggcacttta tagatgccct gcacataatc gacgtgaaac 2451541 aaaatgttcg aatgctcttt cagcacttct cctgccgctt caatcggctg cacggaaccg 2451601 acttcattgt tcacatgcat catgctgaca agcacggtat cgggacggat ggctgctttt 2451661 agatcttcaa tagaaacaaa tccgtcttca ttcacagaaa gataagtgat atcaaacccg 2451721 aacaactctt tcagctgttc taacgattcc gtaacggatg gatgttcaat agaagtggca 2451781 atgatatgtt tgcctgtttt tatctttgac aaagccgctc cttttaaagc cgcattattg 2451841 gcttctgtgg cgcctgacgt aaatacaata tcatattttt ttaggcctaa ggaccttttg 2451901 atttgatttt tggctgcttg aagcagctgt tccgtttcgg ctccatatcg gtgcaaagat 2451961 gaaggattgc caaagtatcg gctgctcgtc tgttcatata cgttcaagac ttcatcgtaa 2452021 ggcttcgtcg ttgaactatt atctaaatat atcatctttt ttactccttt atgaaagcgg 2452081 tacaaggtat gatatttatg ttaccataac aaaatttaat agaaaattac gaaaaactag 2452141 tattgacttc taattttttt accatataat aagatttgtt cgtttcgtca tattatctga 2452201 caattaattg acagaatatt ttaacataat tattaggagg atttttttca tgaaacactc 2452261 actgcctgtc aaagatacca ttattattgg tttcatgcta tttgcgttat tctttggagc 2452321 aggaaatatg atttatccgc cggaacttgg acaagcagcc ggacacaacg tctggaaggc 2452381 catcggcgga tttttactga caggggtagg cctgccgctt ctcggcatta tcgccatcgc 2452441 attaaccggt aaggacgcta aaggccttgc tgacaaagcg caccctgttt tcggcacaat 2452501 ctttactgtc gtgctttatt tatcaatcgg accattattc gccatcccga gaacaggaac 2452561 tgtttcatat gaaattggcg ctgttccgtt tttgactggt gtaccagaaa gactttcttt 2452621 attaatattt acacttatct ttttcggcgt tacgtactat ttagcgttaa acccatctaa 2452681 ggttgtggat cgagtcggaa aaattctgac tcccatcaaa ttcacaatta ttttaatcat 2452741 tgttctcaaa gccatcttca cgccgatggg cggattgggc gccgtgacag aagcatataa 2452801 aggaacaccg gtttttaaag gatttttaga aggctataaa acaatggacg cacttgcttc 2452861 aattgtattt ggcgttgtcg ttgtaaatgc tgtaaaaagc aaaggcgtta cacagtctaa 2452921 agctcttgct gcagcctgca ttaaagcagg tgtgattgcc gctttaggcc tgactttcat 2452981 ttatgtatcc cttgcttatt taggtgcaac aagcacaaat gccattggtc ctgttggtga 2453041 aggagctaaa attttatctg cgtcttccca ttatttattc ggttcattgg gcaacatcgt 2453101 actcggagca gcgattacag tcgcatgttt aacaacaagc atcggccttg tcacatcttg 2453161 cggccaatat ttttcaaaac ttattccggc attatcatat aaaattgtcg ttacgattgt 2453221 cacgttattc agcttgatca ttgcgaattt cggactcgcg caaattatcg cgttttctgt 2453281 tcctatttta tcagctatct atccgcttgc cattgtcatt atcgttcttt ccttcatcga 2453341 taagatcttt aaagaaagac gcgaagtgta catcgcatgc ttgatcggta caggactttt 2453401 cagtatttta gacggtatca aagcagccgg tttttcactt ggatctttag atgtgtttct 2453461 aaatgcgaat cttcctcttt acagcctcgg catcggctgg gtgcttccag gaatcgtcgg 2453521 agcggttatc ggctatgtgc tgaccttatt catcggacca tccaaacagc ttaatgaaat 2453581 aagttaatgt cacagaacgc ctgcgttatt gcgcaggcgt tttgtaataa aaaaagagcc 2453641 tgctcattac actgcgggct ctttttcatg gtcgtgatta tctaagcgga tatgtcagct 2453701 ttgatttttt caactgcacc tggcgcagcc ttttctacag cggcagcggc aatttcataa 2453761 gagtcgtcat aatcaaaagc ataaaaacgt ctttccgctt ctttcagctg ttcagataaa 2453821 atatgattct ggcttctgaa ccggtttccg aactgaatga ttttttcaat gaggatgacc 2453881 tgctcgacaa gttcctctga ttcccggctt gccctgttga cgatatcttc tgcttgtttc 2453941 aaatgggctc cggcttcttc catatttaat ggaagttcgt ttagttgatt gaccgtttct 2454001 tgaatatgat gatgcgcgtt ctccagcatc tcttgaatat ggctcggaat gcctggaatg 2454061 ttgctagtct tcagcagtct tgctgtctca gaaattgttt ttttcaaatt gctgagcgtc 2454121 tccctcgcct gaagctcttc ttttctcagc gcttgcagat tttcacgata ctcggcatgc 2454181 tcttttttca cttcttcaat ttgcttctct attgaagcaa cttcttctac taaaagtgag 2454241 taggcgacat gctctgcatc aagcttatct ttaacggatg atagcagctt tccaatttca 2454301 tcaaggcgct tttcaaaagc ctgctgtttg ccgagctcac cggctgtcag cctgtagctt 2454361 tccttcacca gctcagtttc cgctttcgta tgctctttct cttctttaag cttgtcgtaa 2454421 gcaataatca attcaggcat tttgcttagt acggattgac cggcttcaac ttcgccctcc 2454481 agctgctgat aaacagattg aatattttcg tcaatgagct gcaggattgc ggacgcttca 2454541 tcaatatcca gttcagtcat caggacatgt tccgctcgtt tcagctggtt tgacagattt 2454601 tctaattcct tatcaagctg gatatgctca agcttgtacc ctttttcttt catttcgcca 2454661 tagccatcct tgagctttgc aatctgtccg ggcaccgtct gtttacagtc agctaacagc 2454721 ttcggcacat catctatgta tgactgaagc cgttcaagat tgcggtcctg ctcaagcagt 2454781 acttttcgtg cagtaatata gtttccgcct tctgtttctt cttcaaattg tttgatgccg 2454841 ctccaaattt cgtccagatc cttttcaagg ctgtcataaa gctccccgta aaggtggctg 2454901 taagccagca ggttttttcg agatttcgaa tagcgctccc tcacctgttc aatctcttca 2454961 cggctctttt cctcacttgt gacaagatcg ctgatttccc gaagaatctt ttcaatgctt 2455021 gattcagccg ctgtcagcag gtcgtcgata tgaacgagca cttgattggc ctttttaaac 2455081 cggtatttgt ctgcattttc ctcggcatca taaaggagct cttcaacttt cggcatgtgg 2455141 gctgtgacaa tctcatccca ttcttcacgc cacttctcaa agaactcttc tgtctgaccc 2455201 gtcattttta aatgttttat tttagacatt tcttccacga tcgaccgatt cagaatttca 2455261 atcttccacg attccagccg gtcgatttcg gcgtagattt ttttcctgaa aaagtagcct 2455321 gccgcaaaca gcgcaagcag tacaattaat aatccaatga caaactccat aatgagcccc 2455381 cttgctgttt accttaatct gtcagggtgt tttatttatt cagaaagatt tcaggatatg 2455441 tattgagaaa aactgtcgtt ttcattgtta ttatgatacc atgtaacaaa cattttttga 2455501 ccagaaatca aaaacttttt gtgcaaaatc ggcaggattt gactattttt tcatggggtg 2455561 acatcaatgc aaaagcgaga cggacatatt cacacaccat tttgccctca cggctccaat 2455621 gacacactca gacaatatgc agaagaagcc ttaaaaaaag ggttcgaatc gattactttt 2455681 accgaacacg ccccattgcc gccatctttt accgatccca cgccgctgaa agacagcgcg 2455741 atggcgcaag cttctttgga acgctatatt catgaaattt ccggattaaa aaaagaatat 2455801 cgcggacagc ttagcatacg gacagggctt gaagtcgatt atatcgctga atttgaagac 2455861 gaaattacat tattcctaga cacatacggg ccatatttag atgacagcat cttatccgtt 2455921 cattttttgc gcacagactc ttcctatcta tgccttgatt atgacgagca taccttcaaa 2455981 gagctgattt cagcctgcgg aagcattgaa gcggtatatg aacaatatta ccggagtatc 2456041 tattcttcca ttgtagcatc tctcggcgtt tataagccaa aaagagtcgg tcacatcaca 2456101 ctcgtccaaa aattcatcaa gctgtttcca tacagcatgt cagagcatat tcgcggcctc 2456161 gtttctctgt gcctgaatgc cattgaagaa aacggaatgg agctcgactt caatacttcc 2456221 ggcttaagaa aaacttacgc tggcggtatt tatatcgagg attggatgct gaatgaagcg 2456281 aagcaaaaga agatcccgct tgtgtttggg tctgatgccc atcaagcggg agatgtcgga 2456341 tatgcgtatg aggcgttttt ggaacggtgc tagttggtga gcgccacgtc tcctgtccgg 2456401 aagacgcttc tgatccaaat cttgatttct tcaaaataca ttttataaaa atacggctcg 2456461 tgcggctgca tgtagagtac ttctgaaata tattgaggct ggagataggg catcatcaag 2456521 agagatttta attggagaat aaaatgaggc agcggcagcg ttaaatattc acgctgtttt 2456581 tctccttcct caatgatcag ctggaagata tacttttcct tcattagata tgtcgacata 2456641 atttccctga ttaatgtgga gtcaattgtg acttcccggt agacaaaacg agttaattga 2456701 cgatgattat gctgatagga taaaatatcg aaaaccaatt gaagaagctg ttcctgcgtg 2456761 ctttgagtag agatattgct tgccgctgtt tcaagcgttt tgctgtagcc ttcgtaaaac 2456821 tctgaaacta agtgttccat caagcctcct ttgcctttaa aatagtagga gatgtgcgca 2456881 acatttacat cagctgactt tgcgatttca cggacagacg tgccagaaaa tcctttttgg 2456941 ttaaaaagca tgacagcaga ttcaataatt ttgtctttgg tgcttacttt catacggctc 2457001 actccttcct cttgatacta ttcaagcaga aagccgctgt tcctgtaaga acttatcgac 2457061 aaatgccggc agaaaagccg gaactttgtt ttatattata gaaaaagtga gggttttcca 2457121 tgttccatgt cgaaaaacaa tctggagata aagaaaaaga ctatcagctt ctgctaaaac 2457181 agctcgaagc catgaccgaa gacgaaacag accaaatagc taactatgca aatgcctcag 2457241 cactgctgta tcattcgctg cctgaagtca actgggcggg tttctatttt gccaaagaag 2457301 aggatggaca gcttgtgtta ggtccgttcc aaggcctgcc ggcatgtgtt cggattcctt 2457361 tcggcagagg ggtttgcggc acagcgtacg caaacggaaa agtggaacgt attgaggatg 2457421 taaacgcgtt tccgggacat atcgcctgcg atgcagcgtc tcaatcagaa attgtgcttc 2457481 cgattcgtgt agacggaaaa attgtcggcg tcttggacat cgacagccca gtgaaaaacc 2457541 gtttcgacga aattgatgaa aaatacttaa ctcaatttgc cgaaacgcta gaaaaagcgt 2457601 tagcgcagta atataaaagc ccaaaactga tatcgttttg ggcttttttt attttattga 2457661 gtcatgaatc atcaagcggt ttttcccgct ccgtttcgcg ctgtagagcg cttcatctgc 2457721 ctcatgcaca agctctttca gcgacttttt tgtttctgtc gtccagcagg agataccgca 2457781 ggaaatggtt acctcgggtt tcgtattttt tctgaccgcg taaaccagtc gctcggtaat 2457841 ccgtttcccc actgcaaccg gcacatttgg caaataaatc gccagctcct ctcctcccca 2457901 gcgggcaccg acatcatgct ttcggatgtt gcttttaatc actgaagcga cttgaattaa 2457961 aatctcgtcc ccagtctgat ggccgtacgt atcatttaca tttttaaaat tatcaatatc 2458021 aacaagaata aaaacaccct tttgatggat tttcatgctg tattgaattt tttcatctaa 2458081 atacgctcgt gaatacagtt cagtcagctg atctgttttc acgagatgct caaggcggtc 2458141 gcgaagcatt gaattggtta cagccagtgt cgcgtgatga atcagcgcct gaaacagctt 2458201 gtacatttca aatgtaaaag cgtacagctc ctgtttcaat aaaaccgcaa agcctaaaag 2458261 ccggtcgttt tgaatcatcg gagcagccat cagcgagccg taccccgcct tcccaaaaac 2458321 agactggcca ttcccgatga aaaccccttt ttcaccttca tacagctttt ctttcagctc 2458381 attataaaaa tctgacggct tcgcttcttt aaaaaatgct gtgctgcctg ggagcaatgt 2458441 taggttttca aaatggtcta tatgaaaaaa tcccacttct tctgcctgaa acgattctgc 2458501 cattctcaca gccagatcat tcattgtatc agtcaatgtc agccgctgat tcaggcgtcg 2458561 tgatgtttca ttaatcaatt ccaaatttgc gatgcttgct ttggattgtt cgtagagctg 2458621 ggcattttca aacgcttttc ccgcggcgtt tgctaacagc gacatttcat caaggcaggc 2458681 atcagtaaga aagctgtcac ccgttccttc agccttcaac accccgtatg tgccctgctg 2458741 tcctttgatc ggaatatagg cgacagattc atttttccgc aaaatgtctc cggacaaata 2458801 cactttgagc gcaaaggaat cggatttttc cccttccata tacagctctt ttgcaggaat 2458861 ccctaaacat tggtcttgat cgtgcgatat aaataaagaa aactcaaaaa gagaaaatgt 2458921 gcttgtcaag ctttctaaaa gctgcttcag cacatctgtc tgatcaagca gtgaatggaa 2458981 cagctctgtc attttgtata tctttttttg gtagatcgtt ttgttataga gtctttcctg 2459041 tttcatcgac tggtttaaaa atgaagcaac cacgtccgga agcccttcag gaatctcttc 2459101 atcctgcctg cacgcaagat ggaaacgcct gccggagccg tcctcaatca gataacatga 2459161 agcgtttatt tttgaagcgg aaaaacgcgc ttcaccatct gccagttttg tcacaaagtc 2459221 tgatggtgac ggtgtaagcg aaacacaaag ggttgaaaaa taggtttgaa tagccgaagt 2459281 cagccatatg aaagagtcgg tgaatgtgac tttttcagat ttggttaata aaaaatcgag 2459341 catatgataa tgaaaggcgg ataattgatc tttagtttgt tctaccatgt ttttatcacc 2459401 taaaagttta ccactaattt ttgtttatta tatcataaac ggtgaagcaa taatggagga 2459461 atggttgact tcaaaacaaa taaattatat aatgaccttt gtgtgaaata ttgcagcctt 2459521 tttgttcagc ttctatgttt tcattttgtt ccttatcaat aaggtgtatc gtgtaactct 2459581 ctgctgctgg agcgaggata catgaaaaca aaatgtgcat ggtcgaatag agcagacggt 2459641 ttttattttc cacaaaaata aaaccaaagg aggagtcaca ttatggctcg ctatacaggt 2459701 ccatcttgga aactgtcccg ccgtctagga atctctctta gcggtacagg aaaagaatta 2459761 gaaaaacgcc cttacgctcc aggtccacac ggcccaggac aacgtaaaaa attatcagaa 2459821 tacggtttgc aattgcaaga aaagcaaaag cttcgtcaca tgtacggtgt aaacgaacgt 2459881 caattccgca ctttgtttga caaagctggc aaactagctg gtaaacacgg tgaaaacttc 2459941 atgattcttt tagattctcg tcttgataac gttgtgtaca agctaggttt agcacgtact 2460001 cgccgtcaag ctcgccaatt ggttaaccac ggtcacattc ttgtagacgg aagccgcgtt 2460061 gacatcccgt cttacctagt gaaacctggt caaacaatcg gtgttcgcga aaaatcaaga 2460121 aacctttcta tcatcaaaga atctgttgaa gtgaacaact tcgttcctga ataccttact 2460181 ttcgacgctg aaaagcttga aggtactttc actcgtcttc ctgagcgttc tgaacttgct 2460241 ccggaaatta acgaagcgct tatcgttgag ttctactctc gttaatcgtt ttaaaaaccc 2460301 ctgccgctat gcggtcgggg tttttttatc ggctttcgcc tcttgctggc caacactatc 2460361 ttgcgcctgc tgctcccaat gatcccgctg cagccgttct tttgcaatcg tacacatgag 2460421 attcacgctt tagcgctcct ttcatttaaa aggtggtgat tggtcgtgtt tgccctatct 2460481 aatatactct tttcctttca ttcctatgcg gtaaacaaaa agatcctttg ccttcagtgg 2460541 caaaggatct ttttcttatt tatacgtcac aaggaagtat tttttcttcc cgcggcgcag 2460601 aacagtaaat tggttttcga tgcggtcttc acctgatagg gtataattta tttccgtctg 2460661 gcgttcaccg ttaatgtaaa cagctccgtt ttggatgtct tcacgcgctt ggcgtttaga 2460721 aggagataat ttagattgca ccaacacatc tacaagtgaa agctcttggg tgctgtcaac 2460781 ttccatagaa ggaacatctt taaagcctac ttttacgtct tgagcagaaa gctctttaat 2460841 attgccgctg aacagcgctt gggagatgtt gatggcttgc tccagcgcct cgcgtccgtg 2460901 aacaagtgat gtcacttctt ctgccaggcg tttttgcgct tcacgttttt ctggcgccgt 2460961 ttctgttttt tcagcgtatg cttcaatttc ctcttttgaa aggaacgtga agtatttcaa 2461021 gtatttgaca acgtcacggt cgtctgtgtt gatccagaat tgatagaatt catatggcga 2461081 tgttttttct ttatcaagcc agatcgcgcc gccttccgtt tttccgaact tcgtgccgtc 2461141 tgcttttgtg acaagcggaa tcgttaggcc aaacgctttt gctccttctt cttctgattt 2461201 tctgatcagt tcaagacccg ctgtgatgtt gccccactga tcgcttccgc cgatttgcag 2461261 tttacagttt ttgtctctgt aaagatttaa gaaatcataa gattgaagaa tcatgtagct 2461321 gaattccgtg tacgagatgc cggattcaat tcttgagctg accgtatctt ttgccagcat 2461381 gtaattgatg ccgaaatttt taccaacgtc acgaaggaaa tcgatcacat tcattttgcc 2461441 gatccagtca aagttgttcg cgatgacagc tgggttttct gctgcttcaa aatctagaaa 2461501 tctggacagc tggtttttga ttttttggga ccattcggat acgatgtcag cagtgtttaa 2461561 tgtacgctct gctttttttc cgcttggatc accgatgagg cccgtcgcgc cgcccacaag 2461621 cgcaatcgga tgatgccctg caagctgaaa acggcgaagt gttaaaatag gcagcaggtg 2461681 tccgatatgc aagctgtctg ctgtagggtc aaagcctgag tacaagcgga ttttttcttc 2461741 attcagctgt ttatttaacc cttcttcatc tgtcatttgc tgaatcaatc cgcggaagga 2461801 taagtcttca agtaagttag tcataagata aagctccttt tttaattaaa ataaaaaacg 2461861 ccccttcgtt tacacgaagg gacgattgat tatcgcggta ccaccctact aataagagaa 2461921 tgcaaacatt cgtcttatca ctttgcctga taacggatca ggtccgttct ttcactactg 2461981 aaagcctggc cggctttgtt tgcaaaagcg gttcatgagt gtattcgata tatccgtctg 2462041 tgctgatttt caccggccat cagctctctg gaacgtaagg atattctact tgtctcaatc 2462101 tttacctttt catatgaagc tatatcattt ttaacataaa taaaatcctg tgtcaacgcc 2462161 gccttttaat cctccattgt tgacagatct ccagccggca gattaagctc ccatgccttc 2462221 agcacgcgcc tcatgatctt tccgcttctg gttttcggaa gcttatcttt aaattcgatc 2462281 tcacgcggag ccgcatgggc tgcaagaccc tgctttacaa ataggcggat ctcttctttc 2462341 agtttatcag acggctcaaa tccttccctg agtgcaataa aggctttaat gatttctcca 2462401 cgcaccgggt caggctttcc gataacgcct gcttctgcaa tagccggatg ttcgacaagc 2462461 ttgctttcca cttcaaatgg gccgacgcgc tcaccggagg tcatgatgac gtcatcaact 2462521 ctgccttgga accaaaagta tccctcttca tccatgtaag cagaatcccc agacacatac 2462581 cagccgcccg gcatgaaata cgattcatac ttttcagggt tattccaaat ggtatgcatc 2462641 atggaaggcc agcccttttt gatggcgaga ttgcccattc ggtacggcgg tagctcgttg 2462701 ccttgattgt caacgatcgc tgcctccact cctggaatcg gcttacccat tgaacccggt 2462761 ttaatatcca tgcaaggata gttgcagatg agctgactgc ccgtttcggt catccaccag 2462821 gtatcatgga ttcgtttgtt aaaaacttta tgtccccatc tgatgacttc cggatttagc 2462881 ggctcaccga cactgagcac atgccggagt gaagttagat catatttcgc agccatttca 2462941 tctcccgctc ccatcagcat ccgaaaagct gtcggcgcgc tgtaccagac attgacgcca 2463001 agctgttcaa tcgttccata ccagctttcc gggctgaaac gtccgccgac gatgacattt 2463061 gtcgctccgt tcagccacgg tgcaaaaatg ccgtataccg tacctgtcac ccagcctgga 2463121 tcagccgtgc accaataaat gtcttcttcc tttaaatcaa ggacccactt tcctgtttga 2463181 tattgctgaa tcatcgcttc atggacatgc aacacgccct ttggcgtacc agtggaacct 2463241 gatgtatagt gaagcagaaa gccgtctttt ttatccatcc attcgatatc caatcttgtg 2463301 ctttcctgtt tcgctgcttc atcataattg atgatattcg tgccgctctc agcctctccc 2463361 ccgactacga agacatgctg caagtgaggc agtttgtcta ccggtattct ctccagcagc 2463421 tcaggcgttg tgacaacaac ctttgcctca ctgttttcaa gccggtcttt caccgctccc 2463481 tccataaatg cttcgaacag cggcccggcg atggcgccaa ttttgattgc gccaagcata 2463541 ataaaataaa gctcgggtga tctcggcata aaaataaaaa cgcggtcccc tttttccaca 2463601 tttccatacc gtctcagcac attcccggct ctgtttgatt cttccttcat ttctttaaat 2463661 gtgtattttt catccctttt tgcgtcttta taataaagcg ctactttgtt ttttcgaaac 2463721 gattcggcat ggcggtcaat cgcttcatac gccgcattca gtttccctgt ctcatgccaa 2463781 gagaaatgtt tctctgcctc ggcccaatca aaatgccggt acgtttcttc atagtttttt 2463841 aagttatgat ccccctctat tgctggtaac gctttcaagt tcatgcccaa acatccccct 2463901 ttgctgaagt tgtcacaatt attatagtat atattcatat tcttctcaat ttttaaaata 2463961 taaaccatgt tgaaaacgct ttataatttg gtattcttaa agaaggcatg tatttttgat 2464021 aagaattgat gggacggtga attagtggaa catcataaaa cataccattc agcaaacatc 2464081 aaaacagcaa ccggctcttt actgatagaa gggcctgtct ctccagagga tttggcaggt 2464141 tatgagtttc ataaagattt aaccgcattt cgcccgcctc gcgagcagca tgaagcgcta 2464201 gtcgacattg caggccttcc cgaagggcgc attattattg ccagagacgg ccgaaccatt 2464261 gtcggctatg tcacgtattt atatcctgac ccgctcgaaa gatggtctga aggaaatatg 2464321 gaggatttga ttgagctcgg agccatcgaa gtagcgccgg actatcgggg atgcgctgtc 2464381 ggaaagacgc tcctgaccgt cagcatgatg gatgaacaaa tggaaaacta cattgtgatg 2464441 acgacagaat attactggca ttgggattta aaagggatga aaaaagatgt gtgggaatac 2464501 agaaagatca tggaaaagat gatgaatgca ggcggattgg tctggtttgc aacggatgag 2464561 ccggagatca gctcccaccc tgcaaactgt ctgatggccc gcattggaaa aaacgtcagc 2464621 caagaatcaa ttgagcaatt tgacaggctc cgtttttatc atcgttatat gtattaactg 2464681 acactgacaa aggggaaaaa ataatgattg ttgagcaaat catgaaaaga gatgtcatta 2464741 cattaacgaa gacggatacg cttgaaacag caatatgcaa actgaaggaa ttccatatca 2464801 ggcatctgcc tgttgtagat gaagaacgac acgtgatcgg catgattaca gacagggaca 2464861 tgaaacaggc cagcccgagt atttttgaag aaaacaaacg aagcctattt ctcacacgaa 2464921 gcgtagattc aattatgaaa aaggatgttg tctgcgccca cccgttagat tttgtcgaag 2464981 aaatatcagc cgtgttctac gagcatggca tcggctgcct accagtggta caccatcaaa 2465041 aattaatagg cattttaaca aaaaccgatt tgctgcggac gtttgtcaaa ttgacaggcg 2465101 ctgaccagcc gggctcgcaa attgagataa aagtaaacga catcaccaaa agcctcgctg 2465161 agatcagcag tctttgccaa gaccttcaag tgaaaatatt aagcgtgctt gtttatccgc 2465221 atgacgatcc cggtgtaaaa gtgcttgtct tccgtgtaaa aacgatgaat ccgctgccgt 2465281 ttttgcaggc attacaaaga aatggacacc acgtcgtatg gccgtcagag caaagggatc 2465341 tgctatgaga gacagtgtat ttatctattc tccatcctac caaacctata tgtttcatca 2465401 ggagcatccc tttaatcagc agcgggttct gttaacatat gatttgctta agacgatcaa 2465461 tgcctttgat gatggagaca ttgtcacccc cagactcgct tcagaagagg agctttccct 2465521 tgtccacacg gacgattaca ttcaggccgt aaagcttgcg ggcgccggaa agctccccgc 2465581 tgaagaagga gaaagctacg ggctcggcac tgaagacaca cccgtctttg ccggcatgca 2465641 cgaagcggca tcactcttgg tcggcggcac tttaacggcc gcagactggg tcatgtcagg 2465701 acaagccctg catgcggcaa accttggcgg agggcttcat cacggctttc gcgggagagc 2465761 atcaggattc tgcatataca acgacagcgc tgtggctatt caatatatcc agaaaaaata 2465821 tagcgccaga gtgctttata ttgatacgga cgcccaccac ggggacggtg tgcaatttac 2465881 attttacgat aatcctgacg tatgcacgct gtccattcat gaaacaggaa ggtatttatt 2465941 ccctggaacc ggtcagatcc aagaaaaagg aagcggaaaa ggatatggct attcctttaa 2466001 tattccgctt gacgctttta cagaggatga ttcttttctt gaggcttacc ggacagcagc 2466061 ttcagaagtc gccgcgtatt tcgagcccga tgtcattatc agccaaaacg gcgccgatgc 2466121 ccattactac gacccgctga cgcatttatc agcaacaatc aatatatacg aagaaatccc 2466181 ccgtcttgca cacactttgg ctcatcaata ttgcggaggg aaatggattg cagtcggagg 2466241 cggcggatat gatatttggc gtgtcgtgcc ccgcgcctgg gccagaatat ggcttgaaat 2466301 gaagggaatt gacccgggtc acgagatccc gccggaatgg attgttaaat ggcaaaaaca 2466361 atgccccgtg gcccttccgt cgagctggag cgatccggct gatttatatc ctccgattcc 2466421 ccgcaagcct gaaattacag aaaaaaatgc ccaaactgtc agcaaagcat tatatgcgat 2466481 acgttctgaa cagcaaagaa caaagtaaaa aacgaccttt acgaagaggt cgtttttgat 2466541 tttttaatca ctatttccac acgccgattt tccttcatgt gttcatttgt cttgttatcc 2466601 tttactggct ttgtatccgc ataaccgaca gcaataaagc gcttggaggg aagcttctct 2466661 ttagacgtga agtattgaat cactccactt gcccgtgctg ctgatagctc ccagttcgac 2466721 gggtatcggt atgtcgaaat gtttcggctg tctgtatgtc cctcaacctg aatgtcattt 2466781 ggaattgttt gaagaagaac ggcaatttgg tgaagaagtg tttcggcatt tttcagcacc 2466841 tttgcctcac ctgtatcaaa cagcacagcc tcctgaagaa cgagcacgac accgcgttca 2466901 tcccgtttgg ctgtcatttg ggccttcaaa tgattgtctt ttatatatgt atttactttc 2466961 ttgagaagct gatcctgctg atcctcttgc ttcttcgtat cagatgggga tgtattcttt 2467021 ttttctatgg atgtttggtc cggctgaagc ccgttgcctt ccttctggat cgagtccact 2467081 gccgctttga atttttgcag atcgatttgg gacatcgaaa agagtaaaat aaagaacaca 2467141 aggatcaagg tgatcagatc tgtaaaggtt accatccagc tggatgaaga ttgactgttt 2467201 tttccgcttc cattccttct ttcaaaacgt tctcttctaa gcttcatgta cagatccctt 2467261 ttttgttttt acttgttttg gctgcttctg ccattcttcc cgtgagctga aaacgaccag 2467321 ctggctttca aggttgcgcg ggttttttcc ggattgaaca ccgataatcc cttccaccat 2467381 tacctgcttg atgaaaattt cactttctgt tttctcttca agcttagccg cgatcgggtt 2467441 gaagaccata tttgccagta atgaaccata taaagtcgtc agaagcgcaa tggccatgtt 2467501 tggtccgagc atatgcgggt cgtttaagtt tttgagcatc agcacaagcc cgacgagtgt 2467561 tccgatcatt ccccatgccg gagcgaattc tcccgctttt tcaaaaactc gccgcccttt 2467621 tcggtgccgt tcctccattg ctgcgatttc tgaatccatg acgagccgaa tcgtttcttc 2467681 atcccagccg tcaatcgcta aaagcagccc ttttttcaag aatggatctt tgatttcccg 2467741 agcctgatca tccaatgata aaagcccgtg ttttcgcgcg tgatcggaaa gggaaacaaa 2467801 ggttttcaca agatctttca cattgtcttc ctggcggatg aatgcctgct ttaacacaga 2467861 gggcgctttt ttcagctcac ttggcggaaa actgataaaa acagcggcgc aaagtccccc 2467921 tgttacgatg aagaaagagg tcagatcaag aaaagagcgg aaaccgctta ctcccgatcc 2467981 tgaaataatc ccgataacaa taataatcgt tcctaacaca aatccaacag gtgtaagata 2468041 atcaaaacgt ttcatcattt ctccccatga aaaaagcaag aattcaccat aaaggtgaag 2468101 cttgctcttt gtttttctta tgacttggtt gactttctaa gctctatacg gtgcggcagt 2468161 tcgacgatat gctcttcaac cggctcttta ttcatgagct tcgtcagcag tctcatcgca 2468221 acggcgccga tatcatatgt cggctgaaca actgttgaaa gctgaggacg aaccatgagg 2468281 cttaatcttg tattatcaaa accgataatg tcgagatcct ccggaatgga taagccctga 2468341 tcctgagcgg catggataat gccgagtgcc atttcatcag ttgcagaaag aatggctgtc 2468401 ggttttttat ccaggctcat cagatgctgc agtgcttcga gtccggaatc atatgtgtaa 2468461 tccccttcag ctacaaattg ttcattaaac ggaaggttcg cttcttcaag cgcacgtttg 2468521 tagccttgga gttttttcga acggttgatc ggttctgcca ttggtccgga aacgaacgcg 2468581 atgtctgtat gtcctttatc aaccaaaagc ttcacggcat cataaatcgc ctgttcgtaa 2468641 tcgatagcga ctgacggtgt ttcctcctgc tcttctacag aagcggcaag tacaatcggc 2468701 actggagaac gcttaaattc cgccacatgc tcgtccgtaa tgtttccgcc cataaacacg 2468761 atgccgtcca cttgtttgcc gagcattgtg tttaacaagt gcagctcttt ctccatgttt 2468821 tggtcagagt tgctcaaaat aatattgtat ttatacattg tcgcgatatc ttcaattccg 2468881 cgcgcaagct ctgaatagaa aatgcttgag atatcgggaa tgatgacacc tacagttgtt 2468941 gtttttttac ttgccagccc tcttgccacc gcgtttggac ggtaaccgag acgttcaatg 2469001 gcttccaaga cttttttcct cgttgtcggt tttacattcg ggttgccgtt cacgacacgg 2469061 gaaacggttg ccatgcttac attagcttct ctcgctacat cgtagatcgt aatattgctc 2469121 atcctaaaac cactcctttt actggataca cttatcctta tctatagcat aaacacttta 2469181 tgtagagaaa tgtcataatg tccgaattta tgtcgtttat gatttgtaag cgtaagtcag 2469241 tagtgtacat tatttttcat tattcatcaa atttaattac ttctcatgaa attatacacg 2469301 tttttataga tgatgaaaac gtatacttgg tttttataac taaataaacg agaaagcata 2469361 aaaaaaggcc gcaggcgcgg ccttttggat tgttcaatta agcgttgact ttcaccattg 2469421 gcttcagttc attcagccat ttttcgaatt caggaatcgc catttgctga gcagagtcag 2469481 aaagtgcgac tgacggatca gggtgaacct cagccattac gccatcagca ccgatcgcta 2469541 aagcggcttt agctgtcgga agcaagaggt cacggcggcc tgttgaatgc gtaacatcaa 2469601 caaagactgg caaatgcgtt tcttgtttca aaatcggcac agctgaaata tccagcgtgt 2469661 ttctcgttgc tgtttcatat gttctgattc cgcgctcaca aaggataatt tggtcatttc 2469721 cttgtgacat gatgtattca gcagcattga tgaattcaga gatcgttgca gcaagaccgc 2469781 gcttcagaag cactggcttt ttcacggcgc cggccgcttt cagcaattcg aagttttgca 2469841 tgttgcgcgc tccgatttga atgacatcaa tgtagtccag cgcttcttcg atatgagccg 2469901 gagttacgat ttcactgata accgccagat caaattcatc cgctacacgt tttaaaattt 2469961 gaaggccttc aacaccaagc ccttggaaat cgtatgggct cgtacgaggc ttaaaggctc 2470021 caccgcgcaa aattttaatc ccttgttttt tcgcagctgc agcgacttca gctacctgct 2470081 catagctctc taccgcacat gggccgacaa tgaatctttg ctggccgtct ccgatttttt 2470141 cgcctttgat atcaacaatt gtatcttcag gttttttctt gcgggagaca agcagcgctt 2470201 tgctgtgatc ttcttcctga agctctaaac cggctttgaa tatctcttta aaaatgtgct 2470261 ggatggttga attttcgaac ggcccgtcat tgttttcaat gatattgttt aacattgtgc 2470321 gttctctgac agggtcaaat cggttgacac cctgtgcttc cttcgcttta ccgatctctt 2470381 ttacaacatt gccgcgttcg ttgattaatt ttaaaatttg taggtttaat tcgtctgctt 2470441 tctgccttaa aagctctaac tctgtgttgc tcattttttt catcctttcc ctgcacattc 2470501 attttttatt ttgtagttat catgcatctt actataagta attccaaatg gaaatactga 2470561 aatacaaaaa attttataaa aactctactt tattacccaa acgcttttaa gtgataaagt 2470621 aatctatgaa gctatcctac atgatgtgag ggcaatgttc aagggttttt tacaaaaaaa 2470681 agcgccagat gatatctgga cgcttttttc tatgacaaat gctgctcaat agcggcttct 2470741 gtaatttgtg aatgtgaggt atgccatttc acttcaccgt tctggatgat gaatatctga 2470801 gggctttcat gcttgacccc atatgtttct gcaatgaaat tggacagcgg ccgggcttct 2470861 tgtacttgaa gatagtaagc cggcacatcc tcatgctgat ttgcaaaggc atcaaactca 2470921 tgaaatgctg cctggctgat cgggcatgtg gtgctgtgtt tcaagaagac gaaaacgcct 2470981 tcctgttctg caatccgttt aaattcttcc tcagattgaa taagctgttt agccatgact 2471041 caagctcttc cttccctgct cagcgattca actgctcagc ctgtttttgt gcatctttca 2471101 gttcgtcttt tacatcttct ttcgtctgga ggacttgatc ttttgtttca tcagctgcct 2471161 gcatcgcttc ttccctcata tcttgcattg cagtcgatga atccgttttg tcagatttgg 2471221 aacggtctct caaatccttt accttgttca tgatctgtcc agactgatcc gctacaagct 2471281 gtgtgatgtt ggaagttttg tcttttgcga tgctgacata ttgcgtgcct ttttccttcg 2471341 catctgccgt cattttatca gttttgtccc gtaaggcaac agcctggctg ccgagatcgt 2471401 cgcgaagttc tttgcctgat ttaggcgcta gaaaaagagc tgtagtggca ccgatgattc 2471461 ccccgattaa agttccgatt aaaaaatctt tactattaat tccatctttg ctcatcatta 2471521 ttcctcctct tagtattttt ttctcttaca gggctgattt tttcttttgc ttccatttct 2471581 cccaaatttc cattgctgct tgactccaag tgacaacttg attgatctta tcttgattct 2471641 ctctaactga tgccgataca gaccctgccg cttgtttcat ggatgtattg aactgctgta 2471701 cagaagctcc cactccttga acagcatgaa cgaccgtgtt cagcttttct gatttttcct 2471761 gaatatcttc agccaggcgg ttggtcttat gtaaaagctc ggctgtttca gttgtgatgc 2471821 ccttcatttg tccctccagc ccttcaagag tggatgcgac gttttttagt gtcagctgca 2471881 gtgacttcaa tgttttagac aagtagatca ctaatacgag aaatgcaact gcgatgagtg 2471941 caacgctcaa ataaagaata ataatcatct caaacctcct tgctgcagga tatactgctg 2472001 tttacccgtt ttcttcaatc ataaacatgt gtactgggct gtatacatac tattctccgt 2472061 tatgtaagaa aatcctttaa taagctttcc catcagataa ataaaaagca gtgagatcac 2472121 tgctttttat tatgccatga cgttttcgta ggctctcata tatttttgga tatctcctgc 2472181 tcccatgaag atgagaacgg ctttatcatg agcttttaaa acagatgtgt catcttcttc 2472241 aatcagcttg gcattatgaa tttttccctg gagatcaccg atcgtcagct ttccggcatt 2472301 ctcacgggct gagccgaaaa tatcgcataa atacacacag tcggcgccgc tcaggctttc 2472361 tgcaaattcg tcaaggaact gctgcgtccg ggtaaatgta tgaggctgga ataccgcgac 2472421 aatttcccga tcaggatact tctgtcttgc cgcctcgatt gtcactttta tttctgtcgg 2472481 atgatgggca tagtcatcaa tcagcacttg atccccaagc tgcttctcat tgaatctgcg 2472541 tttgacgccc ccaaaggatt tgagagcatg cttaatgatg ctggaatcaa tttcttcata 2472601 atggcataac gcaatgaccg ccaatgagtt taatacattg tggtggccgt acgcaggaat 2472661 ataaaacgta tcatagaacg tattgcggac aaagacatca aaagttgtcc cttccgtgct 2472721 ttttacgatg tttctggctt gaaaatcatt ttcttccccc gtgccataat acacaaccgg 2472781 gacgttcgca tggattttcg gcagatgctc atcgtctccg caggcaataa tgcctttgtt 2472841 gacttgaaga gccatctctt ggaaagcgtc aaatacatcg tcaatgcttg agaagtaatc 2472901 agggtgatca aaatcaatat tcgtcataat cgcataatct ggctgatagc ttaagaaatg 2472961 gcggcggtat tcgcacgctt caaacacaaa gtattcgctg ttttcatttc cctggcctgt 2473021 tccgtctccg attaagaaag acgtcggttt tgcgttttgg atcacgtgag ccagcagacc 2473081 cgtagtcgac gttttgccgt gtgcgcccgt aacggcaaca ctcgtgaatt ttttcatgta 2473141 gtcgcctaaa aacttatgat aacgtatcac cggaattccc tcagacatcg ctttttctat 2473201 ttcaggatgc gtgtctggga atgcgtttcc ggcgatgact gtcatgccgg gtttaatatt 2473261 ttccgcgcta aaaggaagaa tcgtaatatt tcttttttca agcgctgttt gcgtaaaaat 2473321 aaatttttcg atatccgatc cttggacagt atatccatta tcatgaagta tttgggcaag 2473381 cggactcata ccggtccctt ttattccaac aaaatgataa acagtcataa ttgtacctcc 2473441 aacaaacgtc tatctgttcc ccagtatatg acgctcattt caatttgcga ccgcggcggc 2473501 tgaaaagcct cccttagcgg cgtattttat atgttttgtt atgtttagta tcaggttatt 2473561 tctttccgat taaacccaga tatcaagatt tgtctatgca cagctgctgt aaagcggcat 2473621 agctgttaaa tgctctaaac actatcatac catgtttggt gtgaaaatga acccatatta 2473681 ttcgtttatt aaatcacttg ctgtgatcag cacctctcga ggcttgcttc cttttgcctc 2473741 agagatcatg ccttccgctt ccatcatgtc gatcagcctt gccgcacgat tgtaaccgat 2473801 tctgaatctt ctttgcaggc ttgaagtgct cgcactgttt tgctctacaa caaactcaca 2473861 cgcttcgtaa aacagttcgt cctcttcttt cagggcagat ccttgtctta cgagctcttc 2473921 ttgttcaaat aaataggtcg gcggcatttg gcttctgacg tgggaaacga cgcggtcgat 2473981 ttcccggtct gacacaaagt taccttgcag acgaaccggt tttcccgagc cgttttccaa 2474041 aaagagcata tccccttttc cgagaagctt ttctgcaccg gctatatcaa taattgttcg 2474101 ggaatcaacc tggcttgaga cagaaaaggc gattctcgtt gggatattcg ccttaatcag 2474161 acctgtaatg acatcgactg acggacgctg agttgcgacg agaagatgga taccgcacgc 2474221 tctggctttt tgggcgatcc gcgcaatgct ttcttccaca tcgtttggag ccaccatcat 2474281 caaatctgca agctcatcaa taatgacaac taaatacggc agcttttcac ccatttggtg 2474341 ttcagcggtt aattgattaa agcggtcaat gtcgcggaca cctgaatggg caaaaagctc 2474401 atagcggcgc tccatttcct caacgaccca tttcaaagca gccgtagccg ctttagcatc 2474461 agtaatgacc gggctgacga ggtgaggaat tttattgtaa ggggccagct ctaccatttt 2474521 cggatcaatc agcagcacct ttacctcact cgggtcagct ttataaagca ggcttactaa 2474581 tattgtattg atgcatacgc tttttccgga gcctgtagcg ccggcaatca agccatgcgg 2474641 cattttcttc aagtcgataa caacaggatt tcccgaaata tctaatccca gcgcagctgt 2474701 gagcggtgac ttgcttgtcc tgaaagctga gctgcgaatc atttggcgca aatcaaccac 2474761 cttgctcgtg cggttcggca cttcaattcc gatcgtgttt ttccccggaa tcggcgcttc 2474821 aatccgaata tctttagctg agagactgag tttaatatca tcggacaagt tggtgatttt 2474881 attcaccttt acacccggtt caggatgcac ttcaaatctc gtgacagacg gaccctgggt 2474941 tacatggacc acattggcgc ggacattgaa atttttcaag gtcaaatcaa gaagctgacg 2475001 ctgttcttcg atccacgcag tatcatcttg aacctgcgct ggcgggacat caagcagtgc 2475061 aacattcgga aatacatagc tgccgcggcg ctcctctgct ttttgctgtt tatgcgtatc 2475121 tcttttcagc atcatcacat taaaaggaac ggatggccct ttttgagaag atgcgctttg 2475181 ttcagtcctt ttctcctgta caccaggcct ttttttcggc tcttctgaag cttcgcgagg 2475241 tttgtctgcg cgaatttcct gccggttttc aagagttgca gtagacgatt tggaaccctg 2475301 ctccatgtgt tcagttttct caagctctgt atggctgtct ggctgaacat ctatcttcgt 2475361 ttcctgagcc tctcccaggg tgtcataatg attatttatt atgctttctg atggctcttc 2475421 tgattctttt gccacagttt ctgcttgagc cagagcctct gatgaatact catgatcagt 2475481 aaataaaggc tcttcctgac gaatgtccat ttgttcttct tgaacgaacg gggactcagc 2475541 accttctgcc gcgttttcat gatgattgta tactgggctg tctgacggct cttttgcttt 2475601 ttcatcctca gatactgcct ctgtctgaga ttcaggagct gtttgctctt catcaagttc 2475661 agcggagaaa acaggctctt caaatttctc tggctgctgc tccctttgtt cttcctcagc 2475721 cgttgcaggc tcttcgcggc ctacttcact gtctgaaagc ccttcagccg ccgtatctgt 2475781 gagcatctca ggcggtgttt gctcttcggc ttgttcagct gggaagaaag gctcctcttt 2475841 ttccggctgt tgaacgcctg actcaaatgg cactttgtta cctgacggct cggctggccg 2475901 tttcgccagc gcctcatcat gctccgtatc ctttctgttt aaaacgccag aaggctgttt 2475961 ttcaaattgg gtatccggga agaaaggact ttctattttg gaatgcgcct gtgtgtctga 2476021 agcaggatag ccgcgttcac gttcgatctc ttctgacagc agtgttacct tctcttttac 2476081 cgatttatcc ggttcgttca atgtttcaga aggctttttc ggcacatcct ttttaacaga 2476141 tggtttttga ttgaatccat agacaggcga agggatattt gtcggtttaa acggtttctt 2476201 cgccggctct gctgcttgat atgtatgctg ctcttcttca tttctgggac gctctctgta 2476261 aggtgcagca cttggacgag gcgcggattt cggttcgtcc gatggtgtgc ggcgccttct 2476321 caggtcatga tttttgtatc cgtcaggcac gactggaaaa cggaatttgc cttttggata 2476381 ttcataatat attttaggat cttccaatct ttttaattgt ccttcaggat gatgtacttc 2476441 ttgttgctgc ggaatttgag cgggttttgt ctcccgttca gcatcctctt cgctttcgcc 2476501 taaaaacaaa tcaaaaaatt tatgaagcca actcataatt tatctctaac tcccttatag 2476561 ttttctggga cggtttttag tataccactg ctggtcggcc cagaaaagat taagctatca 2476621 gcagaaacaa agccgctaaa caagggctta gcggcttttc acatgattcg ttttttttgg 2476681 cggatttatg ggagtctaaa actgaaatgc gtctcccgcc tcatagtctc cttctaacac 2476741 aaggattcct ttttcagcag gggcatccgg caaatcaagc tctttcgctg agcagatcat 2476801 cccgcttgac ggaacgccac gaagctctgc atccttaatg acaagtccgc taggcatcac 2476861 agcaccgact ttggcaacga caactttttg gccttggtca acgttaggcg cgccgcagac 2476921 gatctgaagc gtttcttctc ctacgttgac tttacatacg cttaatttat ccgcattcgg 2476981 atgtttttct tttgattcta cataacccac aacaaacttc ggagataaat caacgactaa 2477041 tgtttcttca acgccgtttc tgtttaaaat ctcattcaca tcttgcacga atgtttctga 2477101 gagcgcaaca gggccgtttt catcaatggt caagtaagaa gacgcattga aaatgttgaa 2477161 gcccgttgtt tcttttgttt cgttattgaa aattttgacg acgtcgccgt gtttttcata 2477221 gcctaattgt tcgcgtgtca catcttgaag agagatcagg agcgtgtctc ccacaccttc 2477281 tttattataa aaagcgttca taagtaaaaa tcctttctaa tcctttttcg gacggctttt 2477341 cgccaggata aacaccggtt ccagctttcc ttcattgtac aaaaatgata gggcggtaat 2477401 cgggacggtg ccgcctgcaa agaagctcat cgacatttgt cctagaatat cataccccga 2477461 ttcattccgg atgtcagcaa gaatcaaaac gtcctgatga ggaacagaga tcgccagctc 2477521 accttctgca tgctgcttat actcatttaa gatcgcttcg ttcaaaatcc ggcttgcgtc 2477581 gtatccgtcg tttgccctga agaaataaaa gtaattgccg gcaaccgtat cctctttgac 2477641 aaccgtcggc agggaacgga gattaaatgc ggccgtctct ctgatccgct cttttgtcca 2477701 gttttctttc tcaagcatgc gctggtcaat taaacggtag gttttcccga gatctagcgc 2477761 gtaataaatt cttgtctctg cggtatgatc gtcataaatg agcgggatat cttcgctgga 2477821 cttgtccggg aaggaagtcg agcggatgac cggataaatg cgagtttctt tcccggtcat 2477881 ttcctgagcc ttcccttcca ttgccgtcat cgcttcggag acatagtaca cgatctcatc 2477941 aatggcttcg tcttttttca gttcccattt tgcaataatc ggcggcaaat cgagtgtaat 2478001 ccctttttta gtcgtttgat cctcaacacg gagggtgtct ttttctctgt caaacagaaa 2478061 ggagcgattc tcgtgctgaa ggcgctgctt cagtatatct gacagcttcc ttgaggtcat 2478121 tttcaaaccg atgtcctcct ttacgcttta gcgagagagt ctgttaaaaa ctgttcaatt 2478181 tcttcttttg ttttgcggtc tttgctcaca aaacgattta cttcttttcc ttcattaaac 2478241 accacaaagc ttgggattcc gtaaatttcc cactctgcac atgtatcaat gaatttgtca 2478301 cggtctacgt agtagtaggt gaattcaggg aaattcgctt ccagttcagg caggaaaggc 2478361 tctacaaaac ggcaatccgg gcaccaatcg gccgaaaaca taaatacaga ccaatcatcc 2478421 tttaccgctt tttccagctc ttgagttgat tcaatttttt tcatttcata tccctccagt 2478481 tgtttatgtt cttacatgtt ttttatcgat actcgtccat ttggatcata ccaaactgct 2478541 tgaggcaaaa ccacttatat gcaacgaatg aatatgtaag attggctttc ccattatcat 2478601 tatcatattt tatttgcatt atcaagctcg tttcgtttaa catcgtgtac atgagggtga 2478661 aatttacaga tggatataca taaggaggga tttttattat ggagtttatc gtctatttag 2478721 caggagaaat ccacagcaat tggcgcgagg aaattaaaga aaaaacaaaa tcactgaagc 2478781 tcccgattac gtttgttggc ccgatggaga atcatgaccg ctcagacaat attggtgaag 2478841 aaattatggg cgtacagcca aatgccgttt taaaggatga caaagcctct gacatcaaca 2478901 acttcagaac cgccgtcctg atgaataaag cagactttgt gatcgccctg tttggcgaaa 2478961 agtacaaaca gtggaacacg gcaatggatg catcatatgc gatcgcaaaa ggaaaacccc 2479021 tgattatcat ccggccggaa tcgctccacc atcctttaaa agagctttcc aataaagcga 2479081 atattacggt tgaaaccgtt aaccaagcca ttaaggccct ttcctatcta tttgaaacag 2479141 aataagaaaa aagcttgtcg atccgggctt actgctcgtt caacaagctt ttatgaaacc 2479201 tacatatttt ctttaatcgc atccactgtc tgcttatcgc aggctgttac aagtttgatg 2479261 agcatttctt tagcagcagc ataatcatca atatgaatga tagtagcgtt tgtatgaata 2479321 tagcgggaac atattccgat aaccgctgac ggcacaccgc tgttcgaaat atgaaccttg 2479381 cctgcgtctg ttcccccgcc ggatacaaaa tattgatatg gaatatcatg cgtttcagcc 2479441 atatcaagaa cgaattccct cattccgcga tgcatgactg tcgttctgtc aagaatgcgc 2479501 agcaaaaagc cttttccaag ctggccgaat tcatttttgt ctccgctcat atcgtttgcc 2479561 gggctggcgt caagggcgaa aaacaagtcc ggtttaatca tatgagaagc cgtctgcgcg 2479621 ccccttagcc ctacttcttc ctgaaccgtt gcacccgcat agagtgtatt cggaagctct 2479681 ttaccgtgta attccttcag aagttcaatg cttaagccgc atccatatct gttatcccat 2479741 gcttttgata aaattttctt ttcattcgcc atcgtcgtaa acggacaaac aggcacgatc 2479801 tgctgtcccg gtctaatgcc gattttgatg gcgtcttcct tatcatccgc tccaatgtcg 2479861 atcatcatgt ttttgatatc catcggtcgg tttcgctgcg catctgtcaa taaatgcggc 2479921 ggtatgcttg aaatcacacc cggaaccggc ccgttatctg tttgaatttc aacccgctgc 2479981 gcaagcaaaa cttggctcca ccagcctccg agcgtctgga atctgagcag cccgttgtct 2480041 gtaatggatg tcaccatgaa gccgacttcg tccatgtgcc cggctaccat aattctcggt 2480101 gcgtcctctg cgcctcgtct gactccgaaa acacttccca gtctgtcctg aacgatgtca 2480161 tctgcatatt tggctagctc ctgcttcata aaagcacgaa cctgatgctc attgcccggc 2480221 gcgccgggaa gctgcgtcag tgtttggaaa agcgctttcg tttcttgatt catgttttcc 2480281 cctcatttct atgtagtcct tttattttat tagaaacaat gaagttttcc aagcactctg 2480341 acccaatctg ctcgatcagc cgcgtattgc ttaacaggat ttggctgttt ctgtataatg 2480401 aaaagtacga tcaaccagga ggtgctttat tttgaaattg cgtcatcttc ttttaggagc 2480461 aggacttgga atttgtacgg ctgtcgttgt gagacaatat gtgatgaagc cttatatttc 2480521 ttcagaaaaa gcgcttcgaa ttgtaaaatc tgcttttaag cagcggggcc cgattgacgg 2480581 atcatggatt tacacccagc cggagcccta caatattaac ggagaaacgg tacaggtata 2480641 caaaaccggc attacacgat cagctttcgg agaattagaa cagtatgaag tcatggtgga 2480701 tgcgaaaacg ggagaaattg ttgatgtcat tgatacaatc gcctcttaac accggacaag 2480761 caaaaaatag aagccgctgc ctatgcagcg gctctttttt attatatcgc gcgaatcggt 2480821 ttgtataccg gataccacat cgcatcctgc actgcctgta taatgtcttc aggctcttcc 2480881 gtagcgacgc cttccttcat tgcggttttt gcaacttcaa cagcaacggt tgccgaaaca 2480941 gtgcgcaaat cttcaacttt tggaagcatc ggcgccccag gcaccccgac attgaccata 2481001 cctgcgattg cccgggcaca tgcttcaaac atgccgtcgg taattaattt tgattttgta 2481061 acaatcgttc caagaccgag accagggaag acaagcgcgt tgtttgcctg cccgatatga 2481121 tacgtaactc cgttatattc aactggcggg aacgggcttc ctgtcgtgat cagcgcacgg 2481181 ccttctgtcc attcgattaa atcctccggc tttgcttcag aaagagttgt cggatttgac 2481241 attggcaaaa tcgccggccg tttcacatgt gacgccattt cttttacaat ttcttcagtg 2481301 aaagcgccgg aaaccgtaga tgtgccgatc aggatcgtcg gtttcgcctg ccgaaccact 2481361 tcaagaagat caatgcctcc gccgtctccg ttccgctgat aatccttcac ttcatcagcc 2481421 gaacgggcat acggcttttg gaaatcaaga agctgatcca tatcatctgt taacagcccg 2481481 ttcctgtcta tgcaccagaa gcgcttgtat gattcttctt cactcagtcc ctcgcgcacc 2481541 aatgcttccc gcagctgttc ggcaattccg attcctgccg ttcccgctcc gaatataaca 2481601 actctgtgat ctctcagcgg aactttagac gcttttgcac aggataagac tgcggccaaa 2481661 gaaacagcgc cagttccttg gatatcatca ttgaaggtac acactttatc tttatagcgt 2481721 ttcaaaatgc ttcgcgcgtt tttcgccccg aaatcctccc aatgcagcaa tgcattcgga 2481781 aatgtttctc tcgccagcgc aacgtagtcg tcaataaatt ggtcataacg ttccccgcgc 2481841 actctggaat gctggttgcc gacataaagc gggtcgttca agaggctctc ctgatttgtc 2481901 cccgcatcta aaacaacagc cagcactctg ctcggatcaa tgcccgcagc cgctgtataa 2481961 accgccagct tgccaataga aattgcgatt cctccgacgc cccagtcacc gattcctaaa 2482021 attccttccg catcagttgc aacaattaaa tcgatcgtat cgctttgatc tttatactgt 2482081 ttaaaagctt ctttcatacc gtccgggtca tcgattgaca gatagagccc tcgtggtttt 2482141 ctgtattcat ggctgtatct ctgaattgcc gttccgactg tcggtgtgta gacaatcggg 2482201 agcatttccc ctaaatggtc atttaacagg cggtaaaaca gcgtttcatt ccgatcgtgc 2482261 agcgccgtta aatagacatt tttgctcaaa tcgtcaggct gtgcggaata ttgttcatac 2482321 gctcttttcg cctgatcatc aattgttaat accttgggcg gcagaaagcc ttttaaacca 2482381 agttcttttc tttcttcctc agtaaaagca acacctttgt tcaaaaaagg aacagagagc 2482441 acttcaaggc ctcttaatgt tgtttgaatg tctccttcgt ttgttactct gaattgtttc 2482501 accctgcctc ttcctttctg agcataatag tactaggttt gcattattag ccggaaaaca 2482561 tgcagggtaa acataaaaat atgctatcgc ttcattcgct taactgactt tttgatgctt 2482621 ccgtcctcct cccattgaag ggcgcgatac tcggcatcat ggtaaaaaat aaaccaagca 2482681 tctttttctg ctgcgaacgc ctgccatttc tgcttttgcg ggatagaggt catcggataa 2482741 tcatcgtaag ccagcaccca tagcggattg cggtgggcat gtgtcggcat cagatctgcc 2482801 atatgtacgg cagtttcacc cgcatcctcg catatcagga cactgtgtcc gtcgctatgg 2482861 cctccggtgt gatgcattgt aataccctct gtgatcgtta aggtgtcttc aaaggttttg 2482921 acttggccag ctacagcctc ccaattttct ttccaatacg tatttttcga cctgatattc 2482981 ggatggcgca tttcgtccca ttcaacagct gatgtataaa tcactgcatt cggaaagaca 2483041 gagacgagcc gttcaccttc atattccgtt aaaccgcatg catgatcaaa atgaaggtgt 2483101 gtcattgcga tcacatctat atcggcaacc gttaatccga gtgcagctaa tgagggtttc 2483161 acattcgact cttgtgtcac gccatagttt cgtttttgtt tatcagtcag cttgccgtac 2483221 ccaattccgg cgtcaatgat gatattgagc ccatcctttt gaatcaaaat agggtctgtt 2483281 cttagttcaa tctggttttt ttcattgact ggatattttt tagaccaaag cggctttggc 2483341 acaacgccga acatggcgcc tccgtccata tgcgtcacgc ctccgtcaag ccaggtcaac 2483401 gtgatgtttc caattttcat tgtttccatt ttcacccccc cctatcatca tggtagcaaa 2483461 cggcccataa aaaaaacaga ctcctgtcag agtctgtctt tacgttctcc attcaacctc 2483521 agcccgatag atcggctggc cgagtgcaga gaatttttct tcatattctg tcataatatt 2483581 gccttccaga ttgctgttat gcaaatcgag actgacgtat gtcagcagga ggccgtactc 2483641 agagaagctc ttcaaagagt actcaaataa acctcggttg tccgttttaa aatgaatcga 2483701 tccgcctttg cccattactt cttcatattt tttgaggaag tgggaatatg tcaggcggcg 2483761 tttttcatgc cgtttcttcg gccaaggatc agaaaagttc aagtagaccc gtttcacttc 2483821 ccccggctca aacacatccg tcagcgtgtc cgcatctata ttcagaagct ttacattctg 2483881 cgcttcgctg tcttttactt tttggacggc tgtcacgatg acgcttttaa ataactcaat 2483941 accaatataa ttgatgtcgg gattttgttt ggccatacca gaaataaatt ggccttttcc 2484001 tgtaccaacc tcgatatgga tcggattgtc gttgccaaac actgtgttcc atttcccttt 2484061 ataatcagca ggattgctga tggcaatatc tgcgttttca gccaaaaagt catcagccca 2484121 aggcttgtgg cgcattctca tatgattgac acctctatct attatttcga ctaacaacat 2484181 accatgaatt aaaaagaccc gcaagctcgt ttttccagtg tatctctctt aaggccgagc 2484241 gcataaaaaa agagggtccc gtctgctgga acactccttt cccatgtata aaaacgctct 2484301 gttttgaaca atttaacccg tatgatactg aagggatgtg taccgttatg ggtttacatt 2484361 atgagcatca agttcattta ttgaaggata tattgactga ccatcaattg gactgctgcg 2484421 gaacagtcgc agagtacgag cagcttgagc gtgtgattaa atcactgatg gcaaacaccg 2484481 agcttgattc aaatttcaaa aacgtgcttg aagatgttta ccgctacagc caatcaggaa 2484541 tatcgtccaa atccatcgac tcacacatac aagagcatca gaacagcctg tctcaatggg 2484601 tagagcaaat ggattcgtat tcctgattaa tcaacaattc gtttcatgag gatatgcagc 2484661 tcttccattg catcatgaaa ttccttatca ttgccttttg ctttatgcca ggcaatgaaa 2484721 gtaattgttt cagataacac ataccaagcc attcgcaacc gaaggctttc tgtcagctct 2484781 atgccgtaca tgctcagcca gctctcccaa gctggctttt cgacgtagtg gtacagcaaa 2484841 ggcccgaggt ccatcgccgg atcagcgatc atggcgccgt cccagtcaat taaatacagc 2484901 tggttgtctt cagacaatag ccagttatta tgattgacat cacaatggca aacgactttc 2484961 tcaccgaaat gcacttcatg caggtgttct tccaaatact tgatcccttc ttgaatcagc 2485021 ggcgaagatt gctgcacagc aaatacagcc tgcttcagct gagacaaaag agcccccggg 2485081 ttcagcggtt cttttccaag tctcttcagc atgtccagca aggcttttga tgtgtgtatt 2485141 ttacgaagca attcagcaac gggccgtccg ctcatgtctt taggcttcag ctctctgccg 2485201 gtcatccagt gctgggccgt aatgacgtcc ccattttcca tccgttttgt ccaaaccagc 2485261 ttcggaacaa tgccttcggc ggataaaaca gctaaaaaag gtgagctatt acgttttaaa 2485321 aaaagctgct gcccgttatg tttcgcataa tatgcatctc ctgtagctcc tccggcgggg 2485381 aagatctccc aatcgctacc tagtaattgt cccaaccagt tcatatcaat gttcaaccca 2485441 tcatttctta aaatatttta gaattaaggc taatcgtttc tagtctatcc agcgaatgcc 2485501 tttttcgtac gaatcgtata aaaataaaaa agacagctat tgagagtctc atatgctaat 2485561 caatagccgt cctttaaatt ttagcgctat agcacaaact tcgtcaagca aaactcttaa 2485621 gatctgatgc taaatataag ataaccgttc cgatgccgtt tactgcaacc gttttcttga 2485681 tttctgttgg gtcttcctga aatcctgatg gatcacataa aagccgataa ggtatgtcgt 2485741 ttggcagcct ccactcgacg gagtctggac tcgcgtgatg gataacaatg atatctttcc 2485801 attcgtcaac ctcgtcaaga tcataaagcc tgtatgcgat aaggtgttct tttagcgtca 2485861 agcattcaag atggcgctgg atgtctgcag cggacctaag acggaatgca ggatgcgctt 2485921 ttctcagcga gatcagcctg cggatatagt gaacatcttc tttgaatgtt tcacggcgat 2485981 cccagtcgag ctggttgatg ctgtcactgg attgatagct gttttccact ccctgcttcg 2486041 tccggaaaaa ttcctggccg ctgtgaataa acggcacccc ttgggcaagc aaaataatcg 2486101 cggctgcaag cctttgcctg cttcgctttc ggctgtcatt ttcttgagga agcgcaaagc 2486161 tcattttatc ccaaaaggtg tgattgtcgt gtgattcgac ataattgatg gactggcttg 2486221 gttccggaac aatcggtgct aatgccttcc atccggaaga cccggcaatt ccatgcatca 2486281 cagcttgtgc tgattcaccg ttgccgagcg caaaccctgt tgccttaagg tgaaaggtgt 2486341 tcccttttac agcgtcacga aacatatcat taaaaaagcc gatgcccggc attcttggcg 2486401 cgttcgccaa agcagctttc tgttcatgcg gcagcggtgt agccaggtcc cacccttctc 2486461 caaaaagcag gattccgggc tttgccttag ttgctttctc tttcatataa agcacggtgt 2486521 caatatctaa aatcccgagg agatcaaagc ggaagccgtc aacattgtat tcttcaagcc 2486581 aatagaccac gcaatccgca atgaattttc ttgccatcct tctttctgat gcaatatcat 2486641 tgccaacgcc ggtgccgttt gatggcatcc cacattcgtc gtgccggaaa aaataaccgg 2486701 gcactgtctt ttcaaagggg gaattctccc tcttatacac atggttaaaa acaacatcca 2486761 gaatgactcg cagaccgtgc tgatgcaggg tattgatcat ttgtttcagc tctgtttttc 2486821 tcgtttgagg atcatgagga tttgaggcat agcttccctc cggggcaaag aaatgaagcg 2486881 ggttatatcc ccaattgtat gcatcaagcg gcttctcttc atcaactccg gcaaaatcat 2486941 tcaccggcag aagctccaca tgtgtcacac caagctcttt tacatacgct aatcccgaag 2487001 aactgccatt tgcggtttgt gtatcagttt ccgtcagcgc taagtatttt cccttgttta 2487061 tcatgccgct gttttcatgg atggagaagt cgcgaagatg cgtctcatag atgacggcat 2487121 ccacagggtg tgagaatggt ttaagaggag cagtccattt catttgatcc gggcgcaaga 2487181 cgacgccctt ctctccattt acagtcacag ccttggcata ctggtcaact gtttccatcc 2487241 attctgaatt gttgcagatg caaaacaaat actcatatcc gtgaaggtca cctgtgaccg 2487301 tgacggcata gacgcctttt tccaagcgag tcatttggaa tgtgcgcccg cttttattgg 2487361 ggtgtgaaag cttgacagca gctgaggttg cagcaggcgc ccatacttta aatacggtat 2487421 gatccgcggt ataaacggcg cccagctctc cgtcataata aaattcgtca tcaaacgctg 2487481 ccgtccggat gaccgcgcca atttggagat ccgttttgtg gccgctggat gctctgacgc 2487541 aatggatttt tccaaatgtc acaggatggt cggatacgca gacgtacttg tattttgctt 2487601 caagggagta ttcctccctg acagccagag gaaaatctgt tatttctgtc tcaagccgaa 2487661 acggcggtgt catgatttcc ttttgttcag caggaatcag aacagtaatg atattcatgt 2487721 catcgacata cgcttcgaag ctgcggcgga tgctgaccat cggaagctct ctcctccaaa 2487781 cacgtttatg ttttgattct taggggtgaa ggactagatg ccagacgaaa cggggtagtg 2487841 cccatgattt ctccgtcagc atggaacggg attttgtcct tcgtgtaaaa tgtaatgtcc 2487901 ttcgctttaa acatcgtaac gccatccatc tttgtatgtt ttccaaatgc catgagacat 2487961 aaaagccaat attttttcaa aaacggctgg ttttcaacga ttacgatatc aaatgtcttc 2488021 tcgcgcggat ttgctagggg cgccgccttc atgcctcccc cgtaaaacgg atggttggat 2488081 acaacggcaa accagacatc atgaaattcg cgcgtctcgt cttccgtcgt acaagctaat 2488141 gtaaacggct taaaggttgc cgaagcgtgc aaatgagaaa gcggatacac aagaaatcga 2488201 aggcggagaa aaagaaaaac ccgtctcaac ggaaattcca tcgccttttt attgacatat 2488261 gcgtcaaacc cgatcccgat atgattcata aaataaagaa tctgtgattt atcctgaagg 2488321 aaattgacgc tccctaaatg aaaggttctt gttaacgggc gctttacctt cttgatttcc 2488381 tgtatcagat cgattttttt aatagagaac cctcgcgaaa aatcattata cgcgcccgcc 2488441 ggcacaaagc tcagctcaat atcgtcaaca tctttcagcc cgttgacaac ttcatgcatg 2488501 gttccgtctc cgccaatgac gatcaggcgc ttcagcttat attcctgtat cgttgaaatc 2488561 tgtctggcga gcacctcggc gtgtcccgga tgttcagtta aaaatgaacg gtgctcaacc 2488621 tttcgtttga tcaattcttt ttgaatggac ttccaaacac gcaggccgtt tcgatgtcct 2488681 gctgtcggat taataataaa aaaccaatgg ctcatctttc tcacctgctt atgttatgag 2488741 aaaaccgctc aaatcgttct cttttactcc agccactcct gtctgcgata ggagtcagac 2488801 atgcagtaag acaatagagc ctttgcagcc tttacctgat gatgtttgat cggagcagtg 2488861 tttttcttct gccgctcaat ccattcttcc gcgctccgct tatccgctat ttctaagccg 2488921 tatggcggct ccgggtaatc gatgtacgac gttctgctca gaagcaattt tcgaaccgga 2488981 atctcagcct gtttttcctt tacgatcttt gacacaaccg agtccgtacg aaacaggcta 2489041 agccctggat ttaacactga tgcagtctga gaggctgttt tcttgtccca aaaacgattt 2489101 ttagacccta tgtagacact gtcttcctca gcctctaaaa aagaaacgca ataaatttcc 2489161 agaggagaaa taatcacaat gcttaattca accgccgcct gctgaatttt cagcacaggc 2489221 ttatacataa taaaataaga atcaggcagc tgctgggtca gataacgcaa aatgcggtcc 2489281 tgcttcactt ggtttgagag ttgagatatt tctgaaagag tagagcttgc ccatttgagc 2489341 tgaaaatcat ataaatgcct tttataaaaa gaagcaagcg ccaccctgct cttcgggagc 2489401 cttacatgaa tatcttcttc gtcctcaaac cattggtgtc tctcttcttg tatatcggct 2489461 tttatctctt cttttcttct tttcaatgaa aatttttttc gtttctgcac cggttccggt 2489521 tcttcagcac tggcttgcct ttcttcatgc tggcgctccg ctgcttctac tagtgaaagc 2489581 cagcgctctt ttttcaaacg tacaaactgg ttgatataat ggtacggatc aagctcatat 2489641 ctcgatatat aatcatgaat tttgatgatt tgtgccatgt ttgtttctcc actccgcaat 2489701 gaattaagat aattgaaatt tgaatatttc ctcgtatttt ggtgattggt tcaagtgtat 2489761 ttgaaagagc gaaaatcgtt cagccatcat cgaaacctcg ccgctttcaa acggaacatg 2489821 agctggaaat ccatcttcgc ctgtccattt tcttgccagc gtcatatgag gatgatacgg 2489881 tcttttttcc acttgaaagc cggcctgaag tacagcctgc ttcgtatgtt cccgcagtct 2489941 atcaagcgtt ttgtttttct ttggctccag atgtaaaacg cgcggctttc tgcggtcgcc 2490001 gaatacatct atcttgccaa acttaattga aaatggatca atttctgaag caatctctgc 2490061 tagcgaacct tcaagcttct ttatttgtgt ctcatccgcc gctccgagaa aaattaacgt 2490121 gatatgatag tcaagcgggt gcacccattt ttgaaacgtc aatatcggtt cgtttttcgc 2490181 agcctggtag atcggatttg caattccctc aggtatggga acgccgatga aataatgagg 2490241 ccgtatatct ggcatccgtc tgacactccc ttctttgaca gctattattt tatcaataaa 2490301 gaggctgtgc ggatagagga acagtgtatg aaaacactct cgcacaaacg tttattatgt 2490361 taggatatta tatgacactt gttttattca gaaaggaatg acaatgttga aaatcgttgc 2490421 aaacacagct gatctgatag gagatacacc gctagtgaga ttgaatcggc ttcagccgga 2490481 aaatgcggca caagtctatt taaagcttga atttttcaat ccgagcggca gtgtgaaaga 2490541 cagagccgct tatcaaatga tcatagaagc tgaacaaaac ggtttactca agccgggatc 2490601 agttattata gagccgacaa gcggaaatac cggcatcggg ctcgccatga atgcggcagc 2490661 acgcggatat aaagcaatct tagttatgcc tgatacgatg acgaaggaac ggatcaacct 2490721 acttaaagct tacggtgcag aggttgtatt aactcccgga gaggaaagaa tgccgggcag 2490781 catcaaaaaa gcgaaggagc ttgccgaaca aattccgaac agctatattc caatgcagtt 2490841 cgataacact gctaatcctg atgcgcaccg aaaaacaaca gcgcctgaaa tcgcccgggc 2490901 aatagaggaa atcggaaaac cgctcggcgc ttttgtagcc tcctctggaa cgggcggaac 2490961 cattaccgga acaggtgagg cgctcaaaga gctttttccg gatatcacgg ttcatgttgt 2491021 tgagccagcg ggttcgcctg tattatccgg cggaaaacct ggcgcgcata aacttgtagg 2491081 aacgagccca ggctttatac cgccgatttt aaatgaagac gtttatgatg aaattatcaa 2491141 aatctctgat gaagacgcgt atacgacgac aagacggctt gctgctgaag aaggaattct 2491201 tgtcggtcct tcatcaggcg ctgcctgctt cgcggcaatc gaaacagcga aacgcctctc 2491261 tcctgacaaa gttgtggtct gcatgacagc tgatacagga gaacggtact tatcaactga 2491321 tttatggtca tttatttaaa aaaaggactg gcttcagcag aagccggtcc ttttattttg 2491381 caagctcgta aatggcctga gcatataacg ctgtcgatct cagcaggtca tcaatttcga 2491441 tatattcatc cttttggtgt gcgctgtcag ggcgtccggg gaacagcggg ccgaacgcga 2491501 caccggcttt taaggatctc gcataagtcc ccccgccgat tgagattaaa tcagcttttt 2491561 tacccagctg gccttcataa accttttgca gggttttgac taacggatga tctgcggaca 2491621 cgtgatgcgg cttgctgtct ttgaattctc ccagctcaaa ttcagatgcg ctttcgaatg 2491681 tatcgcggat cactttgctt tctgctgtca caggatagcg gatattgatc ccgagctcgc 2491741 ctccttgccc ttctttatag cgcagtgttc cgacatttaa tgtcagctct ccgctgattt 2491801 catcctcaca gtcgatgtcc agtttttttc ctcttgtatc acctgagaac ttatctgtca 2491861 caacttgcac aaaccgcttt cctgcatcgt caagctcagt ctgctggaga aattcgcaca 2491921 ataaaatgcc ggcattgatc ccattgttcg gttccatcgc atggcaggaa agaccgtaca 2491981 tacgcaaaat gagctgtccg ttctctattg cagcttcccc tttttggtcc gtcgtgcgga 2492041 gcatgtcttt aaatgaagac agaatctctt catttttcgg cccttcaatg acagcttccg 2492101 cagcgtcggg caccatgttt aagcgaaggc ctgattgaaa cgagacaagc actgcctttg 2492161 gttcagcttg atttgggcgg tgcggaataa gtaaagaagc atcgatgatc cctttttccg 2492221 cattaatgat cggaaaatcg gcgtcaggcg caaagcccat tgttggcatt tcttcatgct 2492281 tgaaataatg ctctacgcat ctccaatcac tttcttcatc tgttccgata atcattctga 2492341 ctcgcttgga caggggcaaa ttcatgtctt tcacgatttt cagcgcgtag aatgccgcca 2492401 ttgtcgggcc tttgtcatca atggcgcccc ttgcataaat ccgtccgttg cggatttcag 2492461 ctgaaaatgg atcactcgtc cacccatctc ccggcggcac gacgtcaaca tggcaaagta 2492521 cgccgataat gtcatcgccc tccccccatt caatatgacc tgcgaagccg tcaagatttt 2492581 ttgttgtaaa gccttctttt tctccaagct ccagcaatga agtcaggctg gcatttaccc 2492641 cttctccaaa cggtttaccg ggtccggcgg ttgtttcgtc catgacactg ttgattctca 2492701 aaaattcctg tgtatcacga attaaatcct ctttttttct gatcacttca acttcccagt 2492761 tcataatgat cccctttccg caagaaatga cttgcaaaaa ccaaataaaa cgaataatat 2492821 taatggtgtt ttgttaaaac gttcgtaatt ggaggatact atgtttcatc taaaagagca 2492881 gcaaacatcc ataaagcaag aaatcatagc agggctgacg acctttttca caatggtcta 2492941 tatcgtcgtg gtcaatccgg tcattctggc taacgccggg gttcctttcg accaggtttt 2493001 caccgcaacg attattgcct ccattgtcgg aacgctgtgg atggccctgg cagcaaatta 2493061 tccgattgct attgcgcccg gcatgggctt gaacgcttat ttagcctttc atgtcgtaag 2493121 cgcaagcgat ggcggcatca cgtacgcaac agctttcagc gcagtattta cagcaggggt 2493181 tctcttcatt attctatcgt taacgccttt aagaaaacaa cttatagaag cgattccaaa 2493241 caatttaaaa tacgggatca caacagggat cgggctgttt attgctttta tcggtttgcg 2493301 tcaagcggga attgtggcag ctgatgagtc aaacctggtc actctcggca atctgcattc 2493361 acctggtgtt atcttaacgc tggtcggcct tttgatcagc gtggtcctga tggtgctgaa 2493421 tgtaagcggc gctttattta tcggaatggc agctaccgct ttgatcgcct ttttcaccgg 2493481 tcagctccat ttttcaaagg gatttatgtc gcttcctcat ttgccggaag gattgatgat 2493541 ctcaaatcca tttaccgctt ttggcgatgt cattcatcac ggcctgtacg ctgtcgtctt 2493601 ttcttttcta ttagtcacca tttttgatac gacaggcacg atgatcggag ttgccgagca 2493661 agccgggctg atgaaaaaca acaagctgcc gaacgtgcga aaagcgctgc ttgctgattc 2493721 aaccgcgacg acagtaggag ctgttttcgg cacaagtccg acgactgcat ttatcgagtc 2493781 ttccgccggt gtcgcagccg ggggaagaac ggggcttacg gctttgactg tcgcggtgat 2493841 gtttgcggct tcaatgtttt tcagtccgct tgtcagcgcc ttgtcaggta tagccgccat 2493901 cacctcgcct gctttgatta tcgtcggcag cctgatgatg ggctcagttt ccaatatgaa 2493961 ctggaaagag atggacgagg catttcctgc gtttctcgtc attctagcca tgcctttgac 2494021 ctcgagcatt tctacaggaa tcgcgcttgg ctttatttcg tacccaattg taaaagcggc 2494081 gcggggaaaa tggagagaga ttcatccgct cgtcatcgtt ttcgccattc tgtttttcat 2494141 ccagctgttt attttataag gatagaccaa aaaacccaaa cgtcgccgtt tgggtttttt 2494201 atgtaaacaa taaagagaca gcggccgcta aaaaacaaca ggcggcaaac gcatagtgca 2494261 ggatgttgat acagcttttt ctggcccgat aatattcatc actttcctta tcggtgccaa 2494321 ttaaaaaagg ggcatccatg accttgtcaa aaataagcgt caggatataa cggcaaaccc 2494381 ctgtgtatac cagcagcgca atcaccttca gccaaattgg ggaaacaaat atgagaacag 2494441 tgaaagctga cagtagcatg tacatctgcc ttgcatactc gccattcctc agcataactt 2494501 taaaaaacaa ctccttatag cctgtgcaga tcgttcgtct tttaaatatc ctttttgaat 2494561 ttcggtataa taatggtttt cttctcatcc tgtcttttac ttttggcatt cccgcctcct 2494621 gactcatcat catcacaagt cctgcaaggg caagcctgct ttttttctct tcagtcacct 2494681 cagcttcaaa agccgtgaac gaggctgtct ttttcaaact gcggataact gagaaaaaca 2494741 aaaataaaat gccaaaaagc gcaagcaagt gccgctcagt aaaaacaatc aggatagcag 2494801 aaccagcaaa aagaatagct ctgacaaggg tatcgccaat ccatctcgaa atggagcgcg 2494861 gctttctgat cctgtcttgc tttaaggata aaaagaatat atgaaggcca aacaaataac 2494921 acaatagagc agtgctttct gcgaatgtga tgagaacaga atgactgatc aagggaagga 2494981 caatgaaaaa gagaagcagc catttagcca gcgtggccag aaaagaatac aaaagcgcat 2495041 accgtttgag ctgatagatg atttccttct tttgcagcaa aaacactttg tccgcttcca 2495101 ttaaaaatgt acgaatcgaa cctgtaaaca tgatcagcac acacacagca tacagccatc 2495161 tccattccgc cacttcagac cactcataaa gaaggcctct tccgttcatc aaatcaatat 2495221 actgatagat gacaaaagca atcgccggca aaacgatata gagagcgact gtccagtcaa 2495281 tgaccgcatg caacacttta aactgatact tataatagtc aaacagcctt cgaaaaaaga 2495341 gcgtacgccc gttcatagcc gatcaccttg aactgcctta taaaaacagt caagcaatga 2495401 ctgcccctct aatccggtct tgtcctgaac atcttttaac gtgccttgga gaaataatga 2495461 acctttctca atcatataaa accggtcaca gattttttcc gcggtatcga gtacatgcgt 2495521 gcacataaga attccggctc cacgttcttt ttcagcctta agcatgtcca caaagcgttt 2495581 cgtcgatatc ggatcaaggc cgataaacgg ttcatcaatc acatacatat ccggcttaga 2495641 gagaaaggcc tggataagca ttagtttttg ctgcatgccc ttcgaaaagg tgacaggcag 2495701 ctcatgtttg acatgatcta gcgaaaacgt ctgcagcagg ctttgggccc gatgcgcaaa 2495761 ttcactctct tcaatgccgt gaagtgtgct gatcagatcc aaatgctccc acagcgtcag 2495821 ttcttcgtag aaggacggat gctccggaat atatgcaaat gaacagtcgt tccaggcaat 2495881 atgcccttta aaatcttctg aaaggccgag tatcgccttg attgcggtgc tttttcctgc 2495941 gccgttagct ccgatcagtc caaccagttc cccttttctg acttccagaa aaacatcggt 2496001 gagcactttt tttcggcttg tatacccggc ctgttctatt gaagcttcaa gcaaatttgt 2496061 caaaactcac tcacctccaa aatttactac gaaatagaat aaaaaaagtt tctttaacca 2496121 taataatatt gagccgaaat acatagtaat ccaacaagga tggctgccca acgcgaaatt 2496181 ggaaaaaatt aataggagtt atccctagat tcatcactgc aatatcgtgt ataatgaggg 2496241 cgaattattt taacaattac agatgtctgc ctttgttgct atttcgtacg cagttgatag 2496301 tcgtgagttg tggttagtca agtccatccg atcttatgat agggagtggt tttttgaaac 2496361 cttcaacaaa ccgtatgcta actcgaatca aatcagttta catgtttatt caagaaaaag 2496421 gtcttgtgac aacacaggaa ctggttgacg aattcggcat tacacctaga acgattcaaa 2496481 gagacttaaa tgtgttggca tataatgatc ttgttcatag tccaagccgt ggcaagtggg 2496541 agacaacgag aaagaaagta aagattacct cataaattga aaattacata gggccgcctg 2496601 agagcggtcc gatagataac agggcgaaga aactactgag ccttgttttt gtgtgcttat 2496661 aaataaaacc ccgcattcgg tatgcggggt ttttgtcatg cttgcggctc atttagcaaa 2496721 tgaagctctt cctctgtcag ctcacggtat tctccgggtg ccagagcggg atctagggaa 2496781 acgcgtccca tcgaaagccg cttcagataa accacttcat tgccgactgc ctttgccatt 2496841 tgcttgacct gatggtattt tccttctgta attgtcagat atataacggt attgccactg 2496901 tcgtttgttt tgatttccgc ttttgccggc tttgttttat agccgccctc tatgtagaca 2496961 cccgtttcca aatcggaaat gtcttcccga gaaatctgtg attttaaatg gacttcatac 2497021 gtttttggaa catgcttttt aggagaaagg agccgatgtg cgagctggcc gtcatttgtg 2497081 agcagcaaaa agccctctgt atctttatca agcctgccgg ctggaaatgg ctcaaatctc 2497141 atctcctccg gcgtcagcag atcgaccact gtttgctgcc ggctgtcctc agtcgccgac 2497201 agcacgccct gcggtttatt catcataaga taaatgaact ctcgataatc aaccggttcc 2497261 ccgtatacgg tcacctcctg cgtatcagga tcaacgtgct cctttacatc tttggcaggt 2497321 ttgccgtcga tcatcacggc tccagccttc acaacggctt tgacttcttt tctggaacca 2497381 tacccgctgt tggcaagcag cttatcaagt ctcattccca atctctcctt tataaaagaa 2497441 agcccgcagc atgcgagccc tcagtttcat catatctagt tcatcagcct gcatgtctgc 2497501 ctttcctaaa gaaacctggc aaacggcggc ctaaaatttt ctgcaaaaat cctaatcggt 2497561 agccgcaata caggtagaca gctccgccaa cagcggccgc gatcaccaca acaatcgcag 2497621 cttgcatctg gccatcctga taggaaataa agaagcctaa tacccactgc acgattttca 2497681 cggcaatacc cataatggct gataagacca gcatcaaaac agttcgttta acaagtatct 2497741 tatacgaata gcctgcatgg cgcttaatca tgataaaccc atataaaagg gaagcgatat 2497801 atccaagcgc cgtcgctaaa atcgctccgt cagcctgcat cagcttgatc agcggaacat 2497861 tcagcacaag cttgatcacg acaccgatca caaggctgac aaccgcaaat ttttgcttat 2497921 tgatgccctg cagaatagct gcgttgactg taaacaaaga gaacagaatt gcgacaggcg 2497981 aataccaaag caaaatgttt gcccccagtt caggatgaag gctctctgac ccgtaaaaga 2498041 acgtatacgt cggtcctgac aatagagaga tcccgacaac agccggaata attaaaaaca 2498101 ggatcgtctg catcgtttga ttaatctgct gatttaacag cttatagttt ccgcttgtaa 2498161 acgattcagt aatcgttgga attaatgtca gtccaaaagc agttgctagg gaaaccggga 2498221 tcatcacgag cttctgaaca tacagggtta gaatcgcaag catgtcctgg ctgatggctt 2498281 gatgaccggc ttcaatcatc gctttgttaa acgtatttgt atcaatatag ttatacaaag 2498341 ggatggctag tccgacaaaa acgtacggag cagcatagct gaacagctcg aaaaacattt 2498401 tcttgtagct taggtttgct gtcggacccg tattcggcat catcgccagc aggctgccct 2498461 tccgtttgtt ccaataaata taaagcacga ccagccctcc gaaggcaccg atcagcgctg 2498521 cgaaggttgc atagcccaca gcgatgacaa ggccgccgtt gaaaaccttc aaaatcaaga 2498581 atgtcgcact caatagaaag atgatgcgga caatctgttc aacgacttgg gaaacagctg 2498641 tcggacccat catttggtgc ccttgaaaga atccgcggac aaggctcata atcggtacga 2498701 ccaaaagcgc taagctgacc atgcggatga cataaacgac atgatcaatt gtcaggccgt 2498761 tattatcctt gcctcccagc gatatttccg caaacatcgg agccgataga tacagaatga 2498821 aaaaggctat cattcctgtg actagcataa ccgacatgcc cgccttgagc attttcctgc 2498881 ttgtctcata atcccctttt gaattatatt tggaaacaaa tttagaaaca gcggccggaa 2498941 agcccatcgt agcaatattc aaaaataaag tgtattggtt gtatccgtat tgaaataatg 2499001 caccgcctgt cgccccgacc ataatgctga agggaattaa atagaccatc cccagaatcc 2499061 gcgatatata tgtaccgagc gttaatacaa acgtgcctct taacagtttg cttgacatgt 2499121 ttcttcatca ccattttcta cgaagattca acttttctat tttaccacaa ctgggcattt 2499181 agacggtaat aaatacaaaa gcaatcctgt gaacattcat gtccgcggca aaagacgttt 2499241 aaggagcggc tttctttcgc tataatagta ctgcggacgg gtgtccgcac acgaaatgaa 2499301 aagaaagttg atgataaaga tgaaacaata tgacgtaatc gtaatcggcg gaggcccttc 2499361 aggcttgatg gctgcgattg cagcaggaga acagggcgct ggcgtgttgc tgatagataa 2499421 aggaaataaa ttaggacgga aactcgcgat ttccgggggc ggccgctgca atgtgacgaa 2499481 ccgccttcct gtggaagaaa ttatcaagca catccccggc aacgggcgtt ttttatacag 2499541 cgcgttttct gaatttaata atgaggacat tatcaagttt tttgaaaacc tcggcattca 2499601 attgaaggaa gaggatcacg gccggatgtt tcctgtgacc gacaaagccc aaagtgtcgt 2499661 tgacgcgctg ttaaacaggc taaagcagct ccgcgtaaca atcagaacga acgagaaaat 2499721 taaatctgtt ttatatgaag atggacaggc agcagggatt gtgacgaata atggcgaaat 2499781 gatccatagc caggcagtca ttattgctgt cggcggtaaa agcgtgcctc ataccggaag 2499841 cacgggagac ggctatgaat gggctgaagc cgcgggccat accataacag agctgtttcc 2499901 gacagaggtt cccgtcactt ctggcgaacc gttcattaag caaaaaacac ttcagggctt 2499961 atcactaaga gatgtagccg tcagtgtgtt aaataaaaaa ggcaaaccga ttatcacaca 2500021 taaaatggac atgctgttta cccatttcgg cctctcagga cctgccattc tcagatgcag 2500081 ccaatttgtc gtaaaagagc tgaaaaaaca gcctcaagtg ccgatcagaa tcgacttgta 2500141 tccggatatc aatgaagaaa cgcttttcca aaagatgtat aaagaactga aggaagcacc 2500201 gaaaaaaacc attaaaaacg tgctgaagcc ttggatgcag gagcgctatc tcctattcct 2500261 gctcgaaaaa aacggcatct ctccgaacgt atcgttttct gagctgccga aggatccttt 2500321 cagacaattt gtaagggact gcaagcagtt tactgtcctc gcaaatggca cactgtcgct 2500381 tgataaggca tttgtcacgg gaggcggggt atctgtaaaa gaaattgacc cgaaaaagat 2500441 ggcttctaaa aaaatggagg ggctttattt ttgcggtgaa attctggata tccacggcta 2500501 cacaggcgga tacaatatta cctccgccct tgtcacaggc aggcttgcag ggctaaatgc 2500561 cgggcaatac gcccgttctt aatcattact ctttaaatct cttgccgcca aactcacatt 2500621 tgaacattcc ccgcattcat gttagggtga gacttgtttt gtttcacctg attgcggggt 2500681 aattttaaga gaggaatgag ctgccatcgt acgaccatac taagcctgcg agcaagatat 2500741 aggcgtacac aaaaaattag agggtgagaa atgttgaaac atatatctag tgtattttgg 2500801 attgtgattg caatcacagc tgcagctgta ttatggggtg ttatttctcc tgacagcctg 2500861 caaaatgtgt ctcaatcggc acaagcattt attaccgatt catttggttg gtattatctt 2500921 ttagttgtct ctttgtttgt cgggttttgt ctctttttga ttttcagccc gatcggaaaa 2500981 atcaaactcg gaaagcctga tgaaaaaccg gaattcgggt tattatcatg gtttgccatg 2501041 ctgttcagcg caggcatggg aatcggctta gtattctacg gtgcggctga accgatcagc 2501101 cattacgcaa ttagctctcc atcaggtgaa acagaaaccc cccaagcctt cagagatgca 2501161 ctccgctata cgtttttcca ctggggtttg cacgcttggg ccatttatgc cattgtggca 2501221 ttatgcattg cctatttcca attccgcaaa ggcgcacccg ggttaatcag cagcacactg 2501281 tcaccgattc tcggggataa agtaaacgga ccgatcggaa aggccattga ctgtattgca 2501341 gttttcgcca ctgttgtcgg ggtgtcaaca agtcttggtc ttggcgcaac ccaaattaac 2501401 ggcggtttga attacctgtt cggcattccg aatgcgttta tcgtccaatt ggttttaatc 2501461 attattgtga cagtgctctt tttactttct gcgtggagcg gactcggaaa aggaattaag 2501521 tatttaagca acacaaacat ggtattggcc ggattgttaa tgttgtttat gctcgttgtc 2501581 gggcctacag tgctgataat gaactcattt acagattcta tcggacaata cattcaaaat 2501641 atcgttcaaa tgagcttcag actgacaccg aacgatcctg aaaaacgcga atggattaac 2501701 agctggacga ttttctattg ggcatggtgg atttcctggt ctccatttgt cggcattttc 2501761 atcgcccgtg tatccagagg ccggacgatc cgcgaatttt taatcggcgt cttggtgaca 2501821 ccttgtattt tgacatttct atggttctcc attttcggcg tatcagccat ggatctccag 2501881 caaaaaggcg cgttcaatgt agcaaagctg tccactgaaa cgatgctgtt cggaacactt 2501941 gatcactatc cgctgacaat ggtgacatcg atccttgcat tgattctgat cgcagtattc 2502001 tttatcacgt cagctgattc agctacattc gtgctgggca tgcagacgtc gtacggttct 2502061 ttaaatccgg cgaattctgt gaaactcagc tggggtatca ttcagtccgc catggcggct 2502121 gtgctcctat attccggagg gcttgccgct ttgcagaaca cagcgattct ggcagcgctg 2502181 ccgttttcta tcgttatcct gctgatgatt gcctctctct atcaatcgct ctcaaaagaa 2502241 agaagagaga tcaaaaaagc ggagaaactc gataaaccaa gaagtccaag agtgaaaaaa 2502301 gcatattaac aaaaaagatc tttccgcgcc tgcggaaaga tctttttatt tgcgatataa 2502361 aataagggcg gaaaaacagt aaagctgctc gccgtctggg tcgcacgccg ccgaaaccgt 2502421 atatttgata tctatcagct gctcctccga tatccctttt aaaaatgaat tgatttccgt 2502481 ttgtaagtct ttttcatgct cttcatcaaa taccgctacc ttcagcattt tatccgctct 2502541 cctttctcta tcaatctatt ccgtttggaa cagcgttatg atagagaaat gatgattatc 2502601 tcgtttccgg ataaaaagct ttccgtatat gggatttcct ctgtggctcg ccgccgtgct 2502661 gctccacttt cagcagcacg gcataaacaa tgcgcatatg gcagtagctg ataaggctga 2502721 cgctgaaaaa agggacaatg cccggcaggt acgcaagcaa gaaaaagaga gcaacagtca 2502781 gcgcaagcat agtaagcgta tattgcaaat acgccacact gagcaagagc gaaaatttca 2502841 catacagacg ttttttccag tcaaaatgga caagcagcgg aaacacataa aaaagcatgg 2502901 atacgaacaa aaagccaaat atcataatgg cgaagcgcag gatgtgcaga aggaaatgac 2502961 ttggataaat taaggccaaa tcaatataaa tgatcactcc gatgagcgcc agtacagcgc 2503021 cgagcagatt tgaacgaaaa aattcaccct tgtattcctg ccaaaacgtt ttgagcaccg 2503081 gaacgttgtc ctgcccctgg atccacttcc gcatgacagc gaataaagcc gcggtcgcgg 2503141 gcatgatgcc aaacacgccg agaccgagca acgtaaaaaa cagccacagc aagtttgtat 2503201 acgcaaatct cataatccat tcgcaaaaac gcagcatccg tcccagtgag ccatcatgtt 2503261 ccatggcgcc ccctcctttt ttgcattata cattctgcat ctgaaaaagc tctttcatgc 2503321 cgatcggctt cttttcggca accgagcgcc acattccctc accaaccgcg atggagtagg 2503381 ctccagcttc agccccggct aaaatatcat agcggcgcag cgggtctttc cctaaaaaaa 2503441 gatcctcaag caaaagcgga tcacctccgc catgcccccc ttcatttttg accacttgta 2503501 tcgtctgctt tgattcaaaa agcggatagt attcgattgt ctgctcagga aaagcaaacg 2503561 gaattctgga aggttcgtga aattcatttg attcaatacg tccttttgtg ccgttgatcg 2503621 tcagccggta gccttcatac ggggccgaaa aaataatcga gtagcttaac agtgcgccgc 2503681 catcatattt gactgccgcc acgtacgtat cctcgatgtc aatttcctcg tcaaaaatac 2503741 acgcgtcagg cctgtatgca gtatataagc tggactggtc tcctgcttca agatgatcat 2503801 cctttataga agctttagag gaacggggat gccaccttga atagtagtgg catttttctt 2503861 taacacggca cgtcccgcaa aaacgcccgt cttcttccgg caaggggttc cactcactgt 2503921 ccggcccata gtaattcaag gcgccataag caaatacctc ttccggattt tgcccgagcc 2503981 accaattgac gagatcgaag tgatgtgttg atttatggac agaaagaccg ccggaaaact 2504041 gtctcgacct gttccagcgt ttaaaatagc tggcgccatg atacgtatca atataccaat 2504101 ttaaatcaac agaagtgacc ctgcctattt ttccgtccag aatcatttct tttattttcc 2504161 gatgaaacgg gctgtagcga tagttaaacg cgacggtgac ttttccttcg cttttggcct 2504221 ccgcttcaag cacccgattc gcatcctgca ctgttgtcac cattggtttt tcagtaatca 2504281 catctgtatt ccactgaagg ctttttacaa tatatgcgac atgcgtatcg tccctgcctg 2504341 ccacaatgac gatatcaggc tttgagacgc gcatcatctc gtcaaaagca tcttcgctaa 2504401 actcaggcac gtgggccagc tcgggaaatt tcttcttgca aacggcaaaa cgtttcggat 2504461 cggcatccag caatcccgta atctcataat gagttgaaaa ccgctccatc agtggtttga 2504521 taaacatact gaatgctctg ctgctcaatc cgcaaaagac gatgttcttc aatatcctca 2504581 cctctatcgg gcttcagtta gttgagaaat cagctgcagc gcttcctctg ttttttcagc 2504641 atacacaggg ataaacgccg ccatatcgcg attcaattga aaagaatagc cgttcagctg 2504701 ttttttccct ttttcgatct gaacggcata gatcgttttt tctcctgttt ttttattaac 2504761 agttgtataa ggagatgttt tttcaggagg caatccgttt aacggctgaa aattttccgg 2504821 atcatcgtaa gcttgaaaca tgtcttcagg cacgatgaaa acatctccct catgggcggt 2504881 aatttcagtc agcagttttt cctgaaaagc tggaaagata tcgaccttcc cggcattctg 2504941 ctcggcggcc ttttttattt tttcctgtac gccagcctgc atatcagaaa agagaatgac 2505001 atgcattccg tccggcctgc ttgagcatga tgccaaaaag agcactgaga cgatcacaca 2505061 caaagccgta cgtatccttt ttgtcatttc cccgctgacc taaaaagagg ctccagctct 2505121 gtcatagcta aaataaacgc gccggctccg tgcagatcgt ttgtgcttct ttcgcggctg 2505181 acataatagt catagaaacc ggctgacgtt ccgacacata tgtctttgac gagaaacgct 2505241 ccgtcttctg atgtttcggt tttatgctga atcaagcctt gatacgcttt tagcagtgtt 2505301 gtttcgtaag ctctgtctag atagccttta ttgattcctt ttgcgattgc gtacatgtac 2505361 agacaggatc ctgagctttc cagccagtta tcagacctgt ctcccttatc aacgatctgg 2505421 taccataacc ccgtctcttt gtcttgatag cgacagatgc ttttaatcat gtcctgcagc 2505481 gtgtttttcc acacatgacg gttcggatgc ttcttcggca gctcttcaat catgtcagca 2505541 agagacatga cgtaccagcc gatggaacgt gcccaaaatt ccggtgaaca gcctgtctct 2505601 tcattggccc aaggcatttt tttcgcttca tcccaggcgt gataaaaaag tccggttttt 2505661 gcatccttcg tatgctttct catcaatgac tcctgaagca caacctgatc aaacagctcc 2505721 gtctcctgct tcagattggc atatttcagt gcaaacggcc cccccatgta taagccgtca 2505781 agccacattt ggtaaggata accgtctttg tgccaaaaac cgccctcaga cgtccggttc 2505841 agtgttccat ataagctgcg cagccttttt gccgctttga cataccgttc atccttcgtc 2505901 tgctcgtata atggaaaaag aatgagacct gcttgaatgg cgtccagttc atctcttcta 2505961 aataatagat tgccattatc atcgattaag agatctgcat aagccttcgc atactcaaaa 2506021 taccgctttt ccccggttgc ttcccacagc cgcaatacac cgcataagaa aacaccctga 2506081 tggtagtgcc agcggtttgc aggtggcagc tcctcgactg tgtacgtgtt cataatggtg 2506141 tttgccaatg cctccgcgta cgtaagaggc gattttacag cgattgattg atccattgat 2506201 cccatccctt tcctaataaa ttccttcctc gccaaatttc ttcgccaaac gattcgctag 2506261 catgaccaaa atcagcccga ccgccgcttt aaatacgccg actgctgtac tgtagctgaa 2506321 ttggccctgt ttcagccctg cagtataaac atacgtatca aaaatttccg ccacttccct 2506381 gttagtcgca tttaacagca aatacacatg ctcgaagcca agctccagcg tgtctccgat 2506441 tttcaaaatc agcaaaacga cgataacgct tttaatggcg ggcagcgtaa tatgccacat 2506501 ttgccgcagc cgtcccgctc cgtccatttt cgccgcttca tacagctggg ggtcaaccgc 2506561 tgtaatggcc gccagataaa tgatcgtcga ccagcccgct tccctccaga taacctgcag 2506621 aatatacagg ggccggaacc attcttcgtt cagcagaaaa ttgatttttt caccgccaaa 2506681 aaacacaatc agttcattaa tcaagcctcc gtctaccgtt aaaagcacaa acgaaagcga 2506741 tacaacaatg acccaagaca taaaatgcgg gatataaatc agcgtctgaa caaatttttt 2506801 aaagagagca atccgcactt cgttcaatag aagcgccagc agtatcggca ccgggaaaaa 2506861 tatggccagg ttcaaagcaa ataacacgag cgtgtttttt aacaagagaa aaaatgtagg 2506921 ctcagtaaac agcctgataa aatgcttcag ccccacccac tcactgccca aaatgccgag 2506981 gaacggctga taatcctgaa acgcaatcac aattccccac atcgggacat acttaaaaag 2507041 caaaaaataa atacaccccg gcaaaatcat caagtacaaa tatttttgtt gaatcagctt 2507101 gattagtaag cgctttcttt tttctttttt aaaaatgact gcatcaacag ccggcgcttg 2507161 cgcttctgct gttttcattt tttcctagcc tcctttcacg gattcttgca ttcactgtag 2507221 cgcagcaggc aaaagtccgt ctacaatcat atgatcacat cctgttttat ccctttataa 2507281 tcaagggttc agccggtcca cctgaaaaaa agacaccgat attagaaaat gattattgac 2507341 aatatctatc aatctttgga ttaattgtat taaggtgaag tggatgttat gaaatggggg 2507401 gttttatgaa aagaagccaa tacaagtttt actacaaact gatcacgttt ttctgcctgc 2507461 tcagcaccat tccggttatt ttggtcggat tattttcgta cgagcactct cagaaaacgg 2507521 ctatttccaa cgtttcggag gaaaaattcg acacactcca gcagacccag caaagcatcg 2507581 agcatatatt gaaaaccgtc gatcactctt taacccacta tgtgagttcg ccgcctctcc 2507641 ttcgcacatt gtccgagcct ttgcactcag accaatttca aatctataac caagtgaacc 2507701 aagagctcaa ttatctgcaa agctttgata ccgatctgtc caacatgacg ttagtcagtt 2507761 atacgaaaaa atggtacatg aacaattccg gtttgtaccg tttgaataca gacactcttc 2507821 atgaagcagc ctcagcgtac acgaaacaaa aagcgagccg ctcctattgg acgcttgagg 2507881 aaaacaatca tttgatttca accaaagaag gcacagcaga aaactgccgc tacaatatca 2507941 atttaattaa gcagcttcct ttgaacagca caaatacaaa gggattggcc gccgcaagca 2508001 tcccgagctg ttcgcttgtc aaaaatatgc ccggctattc aaacgccaac aacctgttta 2508061 tcatcgatga aaaaggcctc atcatccttc ataacaatat gtctgacgtt ggtgaatctc 2508121 ttcataacga cggctttgtc caaaaagtgc tggcgcaaac ggccaatagc ggacagtttg 2508181 aaacagtgat tgaccggatt cattataaag tcacctatca aaaatctgac tataatgcat 2508241 ggacttattt ttctctcgtt tccctgcctg agttaaaaaa agaagccaaa tcaatcggct 2508301 ggatcacttt tgcagtatgc ctcattttgt taacgctttc attgctgttc tcttggcttg 2508361 gctcccgcca tttttacaag ccgatcaggg tgctttacga atcattcgca agacatggag 2508421 ccatacaaga gaaacaacag cctcctcaaa atgaatttga gttaattgaa cagagcttta 2508481 agcagctgaa ggacagaaat gacgaccttg aagaaacgat gaagcagcag gccactcatc 2508541 tgcagcaata ttttatggtc aggcttatgc ttggaaaact gacggatgag gaggttgata 2508601 accgttttga aagcctcggc ttaaagcaaa attggcggca ccttgccctg cttgtgctcc 2508661 aaattgacac actgaatcat acgccttatg agaaaaaaga tatggatctg cttttgtttg 2508721 ccgtcaacag cctgattgag cgcaacatcc cgacggacaa acatcttgcc cccgccgtag 2508781 ttgacaaaca gcaggcgacg attttgatca atcaaagcgg gacaaaggaa gaattcatgg 2508841 ctgagctgaa tgagactgca aggatgattc aggaaaaagc ggaagctgag ctgcagctgt 2508901 ctgtcagcat cggcatcagc cagccgtttg atgtgctgac aaaagcgaaa acagcctatg 2508961 cggaaggctc agaagcgttg aaatatcggc tgaaagcgga aaacaagtcg atcatctttt 2509021 acgaagacct tgaccagaaa aaaaccttca aaacccattt tccaaagcag cttcagcatg 2509081 agctgttcga tgctgtcaaa gcaggagaca aggagaaagc ggataaatgc ctgcacgcga 2509141 ttttacaagc cattttcacc cagaacacca acccgtatca atttcaaatc gccatcgccc 2509201 gttttttgaa ccatgtgatt gagctgatgc atgtgcttgg gatcgaattg tttgagcttg 2509261 aagaaaacaa aatgctgtat gaccaaattt ttgagctgaa aacgttcgag gataccgaaa 2509321 actggctaaa gaatgagttt attgatccga tgacagacaa agtgaacgcc cgcgcggatg 2509381 cccagtacaa aaatatttcc gacaacatca ttcatatcat ccatcatgag tttgaatccg 2509441 aattgacact ggacgaaatc gcacgcaggc tgcattacaa cccaaattat ttaagcagta 2509501 ttttcaaaaa agaaatggga atttcattca gcgagtatgt ctcaagctac cgacaccata 2509561 tggcgaaaag ctggcttgcc gaaaccgaca tggcggtcaa ggacattgcc gaaaagctga 2509621 aatataaaaa ctcccaaaac ttcatcagat catttaagaa gctggaaggg attacaccgg 2509681 gaaactaccg ccagcaaaaa agaagcatgt aaaaaaccca aaaccgcttg cgcgttttgg 2509741 gtttttccaa tgttattttg cttgtttaaa cgcttcttcg tattcctgaa taatttgttt 2509801 tcctccgctt gactcccatt tttccacttc tttatcgaac tggctttctg tgatgtctcc 2509861 aatcatatat ttgtaggtcg cgtcatcaat gattttcttc agttcgtcac cccgttccga 2509921 ctccgatgcg gaatacaggc tttcagccgg gtttgagacg ataatctttt cattgtcctc 2509981 ggtcagctcc tcgtacgccg tccgaagcgg atctccagtg ttttttaagt aggctttatc 2510041 aatggcaatt aaagcggaca gcggctgaat atcagtctgc cagtctttta cctggctttc 2510101 tttgcgtgta aacgttttgt cctcaccttt gttgtaatga acgccgtcaa tgccataagt 2510161 catcaggcta tagacatctt cttcggcaat tcggtcaaaa aacgccaaga tccgtttaag 2510221 ctcagcttcc gttttcacac tcgttttcgg gaaagcaaac acgccgttat ggcctcctga 2510281 tgcccatacc cgctctttcc catctgggcc ttttatgcgg ttgatgatct cgagcttcat 2510341 cgatttatca gaggcatggt cgcgcagatt gaccgcatct accatattgc caatataaat 2510401 tccggctttt ccttgagaaa acagctcttg ctgctgggtt ttgcttgtga cgggaaaatc 2510461 cttattcata tacccgttat cacgcagctt tttcatatag ttcatcgtgt ctttgtattc 2510521 ctgtgtcatg aaatcaggcg tgaatttgcc gcccgattcc ttccaatctg tcggcatgcc 2510581 ttcatacgag ccaatcgttt taaacgcgcc gtaaatcaag tcattacggt ctgccagccc 2510641 gaatgtatca tctttcccat ccttgtccgg gtcgtcctcc gtaaatgctt tggccacttc 2510701 ataaagctca tccaacgttt tcggggtttt caaatttaaa ttgtccagcc agtccttccg 2510761 aatgacgatc ccctgtctgg aaagcgggcg ctctctgtat atcccgtaga gcttgccgtc 2510821 aattgtcaca tttttattaa tgagtttgtt cattttgttt aagttgggat aatccttgat 2510881 ataatcgccg atttcccaaa acattcctga ccgaaaggca ttcatgactg acgaattttt 2510941 aatatcctgg atggtcacga tttgcggaag attgccggct gcaagcgctg cattcagcct 2511001 gtcttctttc accgcgtctg gaacccaggt gatgtcgagt tctgtatttg tcagcttttc 2511061 aatttcttta atcgccctgt ctttcggcgg ctgctggtga tacaaaatcg ccatccaaga 2511121 cagctttacc tttgaatctg ggccagcttt gccttcagcc gaagactgat cagttccttt 2511181 acagcccgcc agcactccgc cgagtgccag tacaagcaca atcaaaagca ccctccattt 2511241 gtttcccatc gtacccctcc gtttcatatt tctttatcct ttgacagatc ccagcaaagc 2511301 tccttttgca aaatgctttt gtataaacgg atagacaagc agaacaggga tggtcgccac 2511361 cactatgacc gccattttaa tggtttgctc aggcggcggg ctgcccgacc ccatttcaga 2511421 catatccccc tgcataccgc ttgatacaat gacgatttgg cgcagaagca cctgaattgg 2511481 ccattttgct gaatcattta agtacaagat cgctgtcata tacgtgttcc aatacgtgac 2511541 cgcataaaat agtgaaatcg ttgcgatcgc aggaagagac agcggcagca caattttaaa 2511601 gaatatgccc agatcattgc acccgtcaat tttcgcggac tcttccaggc ttgacgggat 2511661 attttgaaag aagtttttca gaatgatcag gttaaaggca ttaatggctg tcggcaaaat 2511721 aagcgcccag taagaatcga gcaatccaag cgatttgacc acaaggaaag tcggaatcat 2511781 gccgccgcta aacagcatcg taaatacgac gagaaacatg agcggctgcc ggccgattaa 2511841 atcacggcgg gataacccgt aagccatcag tgacgaaaga aacatgctga ccgcagtgcc 2511901 tatcactgtc acaaacacag aaacaagcaa actcttataa ataatatctg ttgaaaaaat 2511961 gtagcgataa gcatctagcg aaaaagtggt cggtattaaa ataaattttt tcgacacgac 2512021 ttcttctact gtggcaaagg atgctgcgat aacatgaatg aacggaagta cgcatattaa 2512081 agcgaacatc agcaagaaac cataaatcaa catatcaaac agacggtttt tcagtgaatg 2512141 tgcgatagct cccacctccc tttgtaagcg ttatcatatt tttggaaacc gagctcagca 2512201 tgtgacgata tcgtgtctaa aatgtagcaa atctgtgatt gccatgtcta taatcatttg 2512261 aacagtgtcc ccggccgggc gggggctgcc gcgaattgag accgataaca aaagaaaaag 2512321 agcataatct tagaaaatga ttatgctccg ttctcctcct cgttcagaag ttcagccgta 2512381 ttgatttgtg gcgaaaaccc aagttcattc acggcagatt caatggacca tggccggccc 2512441 ggattatcag agacggcgta ataagtgcca taccggatgt tggtctcaat ggcggctttg 2512501 aaaatcgaca gcagatcggg gtgagaaagc agtgtctttt tcgtccgttc tttttcatgc 2512561 agcgtatcca tttcatctgt cacgactgtt ccgattcgaa ggttgattac tgatagctta 2512621 ttttccaaat aaaacaaatg gccgatctgt tcagaggtca gctttaatac accgtacaag 2512681 ttttttgaca gcggataatc gcttgttgtg atttcccgtc ctaagagcga gcgcccgtct 2512741 ttttcatata catctgtgac atgattgctg ctggcgaaca cgagcttttg aatgccgagc 2512801 tccgctgccg cacggcacag ataatagctt gccctataga aaacatccgt cattttttca 2512861 aactcagcga tgtccataat atcgtatttg attttcacag cgagtaaatt caagatggca 2512921 tcggtatctt ttggaatctt cttcaacagc tcctcataat ttgccgcgtc agcctgaatg 2512981 gaagaggctt tgccatcgaa atgatcttta tcaagcacag tcacttcata gtctgaaata 2513041 agcccttcag caagcagtct cccaatcaca ccatttccgc cggcgatcag cacttttttc 2513101 acgatgttca ctcccctttt ttatagattg cccattttcg gcggggctga cacttttttg 2513161 gcactcacat tcttaggctt attcaaaagt caccggcagc tcctcaagcg cccgaaatcc 2513221 aaaaagcggc cgataccgcc attcaaaatc cgcaagatta aggctgggca ttcgctgcag 2513281 aagagtgtta atcgcaattt gcgcttctaa tcgtgccagc gaggacccta agcaaacatg 2513341 atggccatgc ccgaatgaaa gatgcggatt aggacttctc gtaatatcga agacatcggg 2513401 gttcgtgaat atgctagggt ctcgattagc cgctcctaac aaaagataga cttgttctcc 2513461 ttgacggatc gtcaccccgc agatgtcaat atcctctgac gcaactctgg ctgtcatttg 2513521 cgtggggctt tcatagcgta aacattcctc gactgcggta ccaataagat ctggattttc 2513581 tctcagtttc aaaagctgtt ctggatgctg cagcagacaa aggactgaat tgctgatgag 2513641 attgaccgtt gtctcatgtc cggcgatcgc cagcaatatg cacgtagatg ccgcctcctc 2513701 ttccgtcagc ttatcctttt ctctcccctt caagagcatg ctgatcatat cctgttgagg 2513761 gtggcgtttt ctcttttgaa tcagctcttt gaaatatgcc atagcctgca cagccataat 2513821 attgccctct gttaatgcct ttcttgagcg ggtaaaatca atcgtttgaa tgagactcgc 2513881 agcccactcc tttaattgct ccctatcttc ctccggtaca cctataatgt tagctatgac 2513941 aaaacttgct aaaggaaaag caaagtccga aatgacctcc atcttttttt taccttgcac 2514001 ttgatcaagc aaatgatgga cagtttcaat gatatacggc tgataactct ctgtcgttct 2514061 cggcgtaaac gctccgctgg caagcgtccg caatcgtcta tgatcaggct ggttctgaaa 2514121 cagcatcatt tgattttgca catgtgaaag gtcctgatat ttggttgagc tctcaggcag 2514181 cggggtgcgg actttgaatc tcgcatcttt caaaatagca gccgtttctt catatcctgt 2514241 gacataccag cccgggtatt ttaagaaact ccctttatag ataggatgaa cagctcgcaa 2514301 tgtgtcgtaa aaagaatatg ggtttttcaa aaactcagaa gatgcagttg acgatgcaat 2514361 tgtcacgtga ttttctcctt tctgttcaaa aataaaaaca atcgacatca taccgattgc 2514421 ttttattgat tctttcagct tttcgcactt aaactagcct tcatttcttc gactgattca 2514481 acttcaaagc ctaaatcact cagcatttta tgatcctccg tctcctcttg cccggcagtt 2514541 gttaagtagt ctccgacaaa aatggagttt gcggcgtaaa gccctaatgg ctgcaatgtg 2514601 cggagattga cctctcttcc tccggaaatg cgaatttctt ttgatggatt gataaaacgg 2514661 aacagcgcca gcacttttaa acaatacagc gggtttaatt cgttgacgcc ttctaacggc 2514721 gtgccatcaa ttgcatgcaa aaaattcaca ggaatggaat ccgcgtcaag agccttcaag 2514781 cttttggcga tgtcaatgac atcctgtttc gtctccttca tcccgataat ggcgcctgaa 2514841 cacggagaca gccccgattc ttttgcgatt tcaaccgtat tgactctgtc atcgtatgta 2514901 tgtgaggttg tgatgtttga atggtttctc tgtgacgtat tcaaattatg attatagcgg 2514961 tctactcctg catctttgag ccgcttcgcc tgctctggct tcaacagtcc aagacatgca 2515021 caaatcttca gtccatacgt ctctttaatt tcctgaaccg catctacgac ctgatccact 2515081 tctctgttag acggacctct gccgcttgcc acgatacaat atgtgccgat attcagatcg 2515141 tgcgcccgct tcgcgccttc aagcagcgtt tccttattca ccatccggta agactcaatc 2515201 ggcgctttcg aaatcgcaga ctgtgaacaa tagccgcagt tttccgggca gagcccggat 2515261 ttcgcattca taatcatatt gagctttact ttttttccgt aaaagtgttt tctgatgtga 2515321 aaagccccgt gcattaatag caaaatatct tcatcaggac aatgtaatat tgaaagcgcc 2515381 tcttcgtcag tcacttctgc tccagccagc acccggtctg cgagttccat ccattgattc 2515441 attctcatac ccccacttga ttcatcagta atgatagatt gatatggtct tttaccatat 2515501 gtagaaccgt ttctttcgtc acgttggcaa gctttggcgt aacccctaaa atcggcacac 2515561 cgcataagcg ctcaatcatc tcaggattgg ttttttcatc ttcatcagga gagtcactga 2515621 ttccattgat gataattccg gcgattggaa gccccatgct ttctgcatat ttgacagtta 2515681 aaaaggtatg attaatggtt ccaaggcgag gacgcgccac aataatcatg ggaagctgca 2515741 acgcttttat gacatgactg accaaatagt cctctcccaa tggcacagaa ataccgcctg 2515801 caccttctac gatgaagcat tcatgttttt ctctaatccg cccccaatgg cttaaaacct 2515861 cttccatggt gacagtcttt ccctcaagtt tccctgcaac gtatggtgca agcggcgcct 2515921 tgaaggcaaa aggcgtaatg tcttcatgag aaagactggt ctgcgacata tctttcagca 2515981 aacttgtatc actatctgga tgatggcgcg atatcccgct taaaaatggt ttatacaccc 2516041 cgacatgtct attattgtct ttcaataagg cagcaagacc gctggatata accgttttcc 2516101 ctacttctgt atcagttccc gtcacaaaaa aacccctcaa atgatgtgca gctcctttcc 2516161 gattgaatga aatgtttgca gcaaatgatc aatatcaccc atactgtggt cagacgtgat 2516221 tgtaattcga atccggcttt cacccggcgc aacggttggc ggccgaatgg caggagcata 2516281 aattcccttg ccctgcagtt tttcagcaaa taggaccgtt ttatgggcat cgccaatgac 2516341 tacaggaata atcggtgtgt gatctccttt caccacataa cccatattct tcagactggt 2516401 tctgatcatg ctgatataag aaaataaaag ctgtcgtttt tccctgctgg cttcaatgat 2516461 gttgaaagcc tcgtgagcag ccgcacagct ggctggcgga atagcggttt gaaagataaa 2516521 tgttctggca tggttcagca aaaagtcgat gaagaccgct gatcctgccg caaaacctcc 2516581 ttccgcgcca acagctttgc ttaaggtgcc gataacaatg tcgggacaaa caccaaagta 2516641 ttcactcgtt ccttgtcccg aatcgcccaa aactcctgtt gcgtgggcat catcaacgac 2516701 cacgaaggca tgatagcgtt tcgcaagtga gatgatctga tcaagagggg cgattgtgcc 2516761 atccatgctg aatactccgt ctgttacgat aaaacggcgc tgataacgct gtgtttcatt 2516821 cagcttgttt tcaagatcat tcatatcaat atgccgataa acaactgtat cagccttaga 2516881 aagtcggcag ccgtcgatca tacttgcatg attgagctgg tcacttaaaa tgacatcttc 2516941 cttttctggc aaggatgaaa ggacaccgac attggccaag taaccgctcg aaaacagcag 2517001 ggccgcttct gtcagtttaa agctggcaat cttcttttct agcttttcat gccagaccga 2517061 attgcctgtc gttaaacgtg aaccgctgct tcctgtccca aattgctgca atgctgtttg 2517121 ggctgcatcg atcaaacgtc tatcgcttgc gagccctaaa taattgtttg aggaccagac 2517181 cgtttgattt tcgccatcaa tattcctctc tggaaccggc gctccatcca ttgaccgcag 2517241 gttacgatgt acgccggctt ctttcattct gtctaaccgc tcgtttaacc aggaatcaat 2517301 cttcaaggct cgtaacctcg tggatcgctt gtttcataat ggcaaccatt tccgagagct 2517361 cttcagctgt gctggcaaga ggaggaagaa atgcaatcac gtccccaagc ggtcttgtca 2517421 gcattcctaa ctctctcatt tttaaggaaa ctttgtatcc aatccgccga tcagccgggt 2517481 aaggttcttt agtttccttt gatcgtacaa gctctgcacc gcacataaag ccaagctgcc 2517541 gaatatcccc aacatgagga agagcgtgca gatcttgaag aagaaaatgg agctttttac 2517601 ttttttccgc tacttgttcc acaatgtttt cagattcaaa taatgccaga ttttcaagcg 2517661 caaccgcaca gccaagctga ttgcctgtat aggaatggcc atggaaaaag gtttttaggt 2517721 tttcataatc atcatagaat gccttataga tgtcttcagt ggcaaacgta acggcaattg 2517781 gcaaatagcc tcctgtaatg cctttaccgg cagccatcag atcaggctgg acattctcgt 2517841 gctcgcacgc aaacattttt cctgtacggc caaagcctgt agcgacttca tcaacgatca 2517901 ttaagacatc gtatgttgta catagctcgc gcacgcctgc caaatatcct tccggcatca 2517961 cgatcatacc ggacgcgcct tgtaccattg attcaatgga aagcgcggca atttcctcat 2518021 gatgttcctc aagcagctgt gcaagctctc ggaggcactg atcacggcac tcatcaggat 2518081 caccgctttc agaacgatac acataaggaa tcggggcctt gtaactctcg aacatcaacg 2518141 ggccgtatac gtggtgaaaa agctcaattg aaccgacact gacggcgcca atcgtatcac 2518201 cgtgataccc gtttttcatt gcgatgaatt tttgtttctc gggcttcccg atgttcttcc 2518261 aatactgaaa cgccattttt agggctattt ccatcgcctc tgcgccgctg tctgaataaa 2518321 agacccgcgt gagctttttt gggctgatgt cgattaatgt ttcggcaagc tgggttgctg 2518381 gaacattggt catgcccaat aacgtggagt gcgcaatttt tccgagctgt ttttttatgg 2518441 cgtcatctag ttcttttttg cggtgtccgt ggacattaag ccaaaccgat gaaaaaccgt 2518501 catagtattc cttgccgttt atgtctttga ctttgattcc agtcccgctt tcgatgatta 2518561 aggggttttc atcataatct ttcatttggg taaatggcag ccagaggtgc tttttacttt 2518621 tttctatcaa atcatgagtc atgatcttcc tcccactcta ttaaaatagg ctgcttctcc 2518681 aggtcatgta tgtacgtgtt tacatcattg gatccatcaa taaaaaagac tcggcagccc 2518741 tcttcagtcc cgtattcttt cattgctgta atacgctgat agcccatttt cttacccgca 2518801 acatagcctg ttatgtaatc cggatcgtcc gaccagcata attctgcaac gactgccggg 2518861 tgccggctta cctttgaagc gagcgcaagg gcctctttta ttcttgaatg agctggcacg 2518921 tgactgtgaa gcgcccattt ttcaaaatta gcgtccggcc aatccattct ggagacccgc 2518981 accccttttt cttttgtttg atccattcgc ttgcctgtat gaatatcaaa caacaccgca 2519041 cccctgacat ctgaccattc agggatttgt tcatatgctt tttcaatcac gtctcgtgaa 2519101 acgccttctt tttccaataa caatcgggca agcttttgtc cttcttccgg gcagctcact 2519161 tcattcgtat gcacaggcaa tggctgaatg gtttttatcg attcatgtac ctcttcaaat 2519221 tgaatttgca taaaatcagg ttttcctctt gaatgggata accctttttc taataaagca 2519281 ttgactgtat gcttcatctc atggaaagga ataagccgtt ctccgccgga tatatgcttt 2519341 ccgccgtctt catgagatcc attcattgaa gccctcattc tgacactata aaaagtttct 2519401 tcttgcatca tttctcgccc tttcactgat aactgaagaa cgtgtagcgc ttctcaccta 2519461 aattgttaac caattatatt caaaggttaa caattagaat atattattct ctcctgtttc 2519521 tgtcaataga agaaaggatc gatttatggc agttggttaa aaggaaacaa aaagaccgtt 2519581 ttcacacaaa acggtctttt tcgatttctt tttacagtca cagccacttt tgcaaaaacc 2519641 ggacagcttc atgccttata actgctgttt cgaaatgtcc cgaagcagaa cggaccactc 2519701 ggtagcaatc agcagctccc tgtccagcat agacagctgt caattctttt tcgattttgt 2519761 ccacgccctc agccggcgtt aaccgatcgt gtacaccaac aagactaagg tgcgggcgcg 2519821 gcgcgatcag gctttggatc tccgatgcgg aaaaatgctt tgcaagcgat gggacgtaat 2519881 aataaaagcc gtgcctgtca agattctgtg ttttgatcag cacgtgatga tccacctggc 2519941 tgcacaaatc cacacacacc ttaatccggt catcgagcgc cgctgtccac cacgccatca 2520001 aacctcccat agacatgccg atggttccga tcctgtcagg ctgaacatca gagcgtgact 2520061 gcatatagtc taacgcactt aaactgtcat aaatcatcat cccccacatc acttttccgg 2520121 tgagaagcat ttctttaaat atctcgcttt ccgcttttcc ccgccgatct ccaaaccccc 2520181 aatgatcaat cgcaagaacg ccgtatccga gtgaagtaag ctcatcagaa aaagaaggcg 2520241 ttttcaaata atccgctccc tcaatcagct cactttttcc cctatcatac tggcctccat 2520301 gcgaatgctg aaacaatacg gctgggcacg gtccttctgt tttcttcggc ttcacaaaat 2520361 aagcgggcgc cttttcatgt ccatttaaat cgagcaggag cgtttcaacg atattttctt 2520421 ctctttcttc aatacgtaat gtctcaacac tgattggcct ccgatcaggc aaatcaccaa 2520481 gcaatcgaaa cagttgcttt cttctttcgg ctctcatccc atcacccttc cttattcgct 2520541 tacttcacat ttacgagaca gatctgggtt cccctttatt tttccaacat aaatcacatc 2520601 atttactaaa tatttagtaa atattatgga atatttcgaa aacaattatt gtaaccgctt 2520661 acttttatat gataatatca atttatcaaa aacagatgag ttaatatttt actaaataga 2520721 tgagagggat acccatggtt cgtattaaag atatcgcctt gaaagctaaa gtttccagcg 2520781 caactgtgtc cagaatttta aatgaagatg agtcgctttc tgttgcgggc gaaacgagac 2520841 aaagagtcat caacatcgct gaagagcttg gttatcaaac cgttgccaaa cgccgaaaat 2520901 cccgcgggca aaaacagcgg gctcagccgc tgatcggtgt gctgagctgt ctgtcccctg 2520961 atcaggaaag gcaggaccct tatttttctt ccattcggaa agggattgaa aaggaatgct 2521021 ttgaacagga aattttcatt acaaattcga ttcatctcgg ctcctttcag gaacatatct 2521081 ttcgggaatt ggatggtgtc attgtcatcg gccgtgttca tgatgaagcg gttaagcata 2521141 tcagcgggag gctggagcat gccgtattta tcaatcattc accagatccg caagcatacg 2521201 attcgattgg catcgatttt gaatcggctt cacgccaggc gattgatcac cttttcgact 2521261 taggctacaa acggttaggc tacattggcg gacaagaaaa agagcatacg ctgaaggacg 2521321 gccaaagcat tcgcagaacg attgaagata aacgcctgac cgcttttttg gagtcagccg 2521381 ccccccagcc tgagcatgtg ctgatcggag aatacagcat gcgtgagggc tatcgcctga 2521441 tgaagaaagc aatcgatcaa ggccatctgc cggaagcatt ctttattgcc agcgattcta 2521501 tggcgatcgg cgcattaaaa gcgctgcagg aagccggact gcaagtgccg cgggataccg 2521561 caatcgtcag ctttaacggc attgaggaag ctgaatttgc cagcacgcct ttaacgacgg 2521621 tgaaggtata cacagaggaa atgggccgga caggcgtaaa actgctgctt gaccgtctca 2521681 atggccgaac gcttcctcaa catgtcaccc tgcctacaac attaatcgta agacaaagct 2521741 gcggatgtac agcaaaggag gtgacataag caaagattca tcacgatgat aaggaggaaa 2521801 agatgaaaca cacttttgtt ttatttctct ctcttattct gcttgttctg cccgggtgtt 2521861 cagcagagaa aagctcagca gataccgcaa aaaagacgtt aaccatttat tctacaatgt 2521921 caaccgacag tgaaagagat acgttcagaa aactagcggc agcattcgaa aaggaacaca 2521981 gtgacattca tgtcagcctt catttcccag gcaatgacta tgaaaatatg atgcgtgtca 2522041 gaatggcggc caatgatttg ccagatctat tcgatacaca tggctggggg aaaatcaggt 2522101 acggagaata tacagcggat ctccgggata tgaaatggac tcaagatctt gatcccaatt 2522161 taaacagcat cctcaaaaat aaaagcggaa aggtgtatgc ctatccaatc aatcaggcaa 2522221 aagacggtct ggcgtataat cgcaatattt tagaccgtta cggcattgct ccgccggaaa 2522281 ccatggatga ctttatcaaa gcactgagaa cgattaaaga aaagagcaag ggaagcattg 2522341 ttcccttctg gtttgccgga tatgacaaaa gctcattcgc ccaatattac gaccaattcg 2522401 ctacacctct tctcatcaca gaccctgccc ataatgaaaa aaaacagctc atcaacggca 2522461 cttttcaatg gagtaaattc acttatttat cagaaatcct caaacaaatg cagaaagaaa 2522521 aattgatcaa tatcgacgcc gtcacggcaa aaaaatcaca gctcattgaa ttaatggccc 2522581 aaaacaaaat cgcctttaca atgcaaggcg gcacactcgg ccaagacgtt gcccagatca 2522641 acccgaacgt caaggtcggc attatcccga cacctgccat ccatcccggt gatgacccga 2522701 tatggatcgg cggtgaacgc tacacccttg cagcatggaa agattcgcct caattaaaag 2522761 aggcaaaaga ttttatcgca tttatggccc gcccggccaa tgccaaacaa atggctgaag 2522821 ccacatcgct tccttcaggg ctgaccaatg tgaaagctga tattttctac gcaaacgatt 2522881 atgagtatta tcaagatgtc aaagtcgagc cttacttcga ccggttatac ttgccaaacg 2522941 gaatgtggga tgtcctgggc acggttgggc aggagctcgc ggctgacatt ttggcgcctc 2523001 aagacatttc gcagaagctg ggaagagaat ataaacgact ccgggagcaa tccgaaacac 2523061 agggagctga aaacaatgag tgagatcgca agggacgttc atgtgaaaca ggttaagcca 2523121 aaaaagcagt cctcactttg gtggatgtac attcctgctt tgctctccgt tctggtcttt 2523181 atgatttacc cgtttgtgaa aggcacattg attaccttta caaactggaa cggattttca 2523241 caagtctacc aatgggttgg attcgcgcaa tatgaaaggc tgttttctga tcctgatact 2523301 tggcatatct taaaaaacac gctgcattac gggcttggca gcaccttttt tcaaaatgtg 2523361 gtcgggcttc tgtacgctct cctcttaaat caaagcatta aaacgaaagc ggtaacaaga 2523421 acaattgtgt atttgccggt gatgatcagc ccgctcatta tgggctacat ttggtacttt 2523481 ttcttctcct atgacggagg cgcgctcaac gatttgctcg gggtcttcgg catcagccct 2523541 attaatgcgc tcgccagtcc ctcgctcaat ccatggatca ttgtcatgat taacacctat 2523601 caatatgtcg ggatcgctat ggttgtctac ttagccggtc tgcaaagcat tccgaaagac 2523661 tactatgaag cggcgcaaat ggatggcgcg aaacaaggcc agcagttttt taccatcacg 2523721 ctgccgctgt taatgccctc cattaccatt aatatagtca tcaacattat cggaggctta 2523781 aagctgtttg acgtcatcat tgcactcacc gcaggcggcc ccggaaatgc gtcacaatcc 2523841 atgtccacgt ttatgtatga tttgtatttc aaacggcagg atgccggcta tgccgcaacg 2523901 caaggcatat ttatggcatt tgtcattttg atcatcagct tttgcgcgct tgcgtacttt 2523961 aaaagaaagg agacggaaat gtcatgagag ccgcccgtac aaaaagcatg cggatcatta 2524021 cgcttcttgc agccattgtg gcctgtgcgc attttattcc tttttatatc ctgctgacca 2524081 cttcattgaa agcaaaagga gactacagtt cgaaatggat atttccagcc gacatctcct 2524141 ttcataattt ttcagaggcg tgggagcgcg cttcgctagg aaactctttt ataaacacca 2524201 tgatcatcac aggtttttct gccttgttat taattatatt cggctcactt gccgcctacc 2524261 cgcttgcccg gcgggaaacg aaactgaata aagccgtttt tgccttgctg atttccatta 2524321 tgatcatccc tccgttaacg tccatggttc ctttgtaccg aatggtcgtg gacgccggaa 2524381 tggtcaatac acacgcaatc gccattttca tcaatacagc ggcttacatg ccgttaaccg 2524441 tattcttata ttcaggcttt atccgatcga ccattccaaa agagcttgta gaagccgcaa 2524501 gaattgacgg tgcaggcatg ctgaaaatct tttttacgat tgtgtttcct ctgctgaagc 2524561 cgatcactgc gaccatctgt atcatttctt gtgtctttat ttggaacgac tatcaatttg 2524621 ccattttctt tttacaagat caaaaggttc agacattaac agtagccatg gcaggttttt 2524681 tcggagaaaa cgcaaacaac cttcatttag ttgccgcagc ggcacttatg gcaatgctgc 2524741 cgatggttgt tctgtttttg gcgctgcaaa aatactttat tgccggcctg tcttccggag 2524801 cggtaaaggg ttaacattaa agggggaagc aatatgaaaa agattacatt tatcggtgca 2524861 gggagcacga ttttcgccaa aaatgttttg ggagactgcc tgttaacaga ggcactgaat 2524921 ggatttgagt tcgctcttta cgacattgat cccaaacgcc tgcaggaatc ccagctcatg 2524981 ctcgaaaatc taagagaccg ttataaccca agtgtggcca tcaacagcta tgatgacaga 2525041 aaactcgcct tgcaaaacgc aggctatgtc atcaatgcga ttcaggttgg aggatacaaa 2525101 ccgagcacag tcatcgattt cgagattcct aaacggtatg ggctgcgcca gacgatcgcc 2525161 gatacagtag gcatcggcgg gatattcaga tctctcagaa caatcccggt cttatttgat 2525221 atcgcaaaag atatggagga aatgtgccct gacgcatggt tcttaaacta tacaaatcca 2525281 atggccactc ttacaggcgc catgctccgc tataccaata tcaaaacaat cgggctctgc 2525341 cacagtgttc aagtgtgcac gaaggattta tttaaagctc tcggaatgga gcatgacgga 2525401 attgaggaac gcattgcggg cattaatcat atggcttggc ttttggaagt caaaaaagac 2525461 ggcacagatt tatatccaga aatcaaaagg agagcgaaag aaaaacaaaa aacaaagcat 2525521 catgatatgg tgcggtttga attaatggat aagttcggct attatgtcac ggaatcgtcc 2525581 gaacataacg cagagtatca cccgtacttt attaaacgga attaccctga actgatcagc 2525641 gagctgcaaa tcccgctcga cgaatatccg agaaggtgcg tcaagcagat tgaaaattgg 2525701 gagaaaatgc gggatgatat cgtcaataat aaaaacctta cgcacgaacg ctcaaaggaa 2525761 tatggttcaa gaattataga agcaatggaa acaaacgaac cattcacctt cggaggaaac 2525821 gtcttgaata cagggctgat caccaacctt ccttcaaaag cggttgtgga agtgacatgc 2525881 gtcgccgaca gaaaaaaaat tacaccgtgc ttcgccggag aactgcctga gcagcttgca 2525941 gccttaaacc ggacgaatat taatacacag ctgatgacaa tcgaagcggc tgtcacacga 2526001 aaaaaagaag cggtttacca agctgcaatg cttgatccgc atacaagcgc ggagctttcc 2526061 atgaaggaca tcatctccat gtgcgacgat ttatttgcag cacacggcga ttggcttccg 2526121 gaatacaaat aaaaactagg ggaccgctct cccctagttt tttggttttg tttcgccttc 2526181 ccaggccatc atgccgcctt caacattgac tgttttaaag ccttgctcat ccaggtactt 2526241 gcagacgttc atgctgcgca ttcctgagcg gcagataaat acgtactctt tgtctttatc 2526301 aagggtttcc attttttcag gaatatcccc catgcgaata tgaacggctt gcgggatcat 2526361 gccttccgct acctcttcat cttctctgac atcaattaaa tataattctt cgtccgcctc 2526421 aattttttct ttcaaagcgg ctgtgctgat ttcttttatt tccaaagaaa acactcctat 2526481 tcacagtgat catgttcagt atatcaaagt cagccgaacg attgctattc tgagactgat 2526541 gaaaaaaaat ccccttttgg caaaggggat tttttctagg cttagtttgc cacaatattg 2526601 acaagcttcc caggcaccgc gatgattttc cgaatcgttt tgccttcaag ctgctctttg 2526661 accttttcat ctgcttgagc aagctgttcc agctgttctt tcgttgcatc ggcaggaacc 2526721 tgtaatttcg cttttacttt tccgttcagc tgaacaacga tttcaacttc atcatccaca 2526781 agttttgttt catcatatac aggccaagct tcgtaggcaa ttgtgccgga atggccaagc 2526841 ttctcccata gctcttccgc taagtgtggc gcgacaggag aaagaagctt cacgaagcct 2526901 tccatatatt ctttcggcag ttctgttgct ttataagctt cattaataaa gaccatcagc 2526961 tgggaaatac ccgtgttgaa acgaaggcct tcataatggt ctgtgacttt catgaccgtt 2527021 tcatgataga cgcgctccaa tgtttcaccc gcgccttcaa cgatttttcc attaagctca 2527081 ccgctgtctt caataaatag gcgccataca cggtcaagga aacggcgcgc accgtctaat 2527141 cctgattcag accaggcgat tgaagcatca agaggtccca tgaacatttc gtacaatctc 2527201 agcgtatcag caccgtgaga ggccacgatt tcgtcaggat tgacaacgtt ccctttagat 2527261 ttactcattt tttcgttgtt ttcgccgaga atcattcctt ggttgtacag cttttggaac 2527321 ggttctttcg tcggcactac gccgatatca taaaggaact tatgccagaa gcgggcatac 2527381 agaaggtgaa gcacggcatg ttctgcaccg ccgatataca tatcgaccgg aagccatttt 2527441 tccaattttt ctggtgatgc cagctgatcc ggattgtgcg gatcaatata gcgcaagaaa 2527501 taccagcagc ttcccgccca ttgcggcatt gtattcgttt ctcttcttcc ttttttccct 2527561 gtctcagggt ctgtgacttc cacccactct ttaatgttcg caagcggtga ttcgcccgtt 2527621 ccgctcggtt tgatttcatc cgtttttggc aaaatcagcg gcagctcctc ttccgggaca 2527681 gctgttgacg ttccgtcttc ccaatgaatg accggaatcg gctcgcccca ataacgctgg 2527741 cggctgaaga gccagtcacg aagacggtac gtcactttct tctcaccgtt tttcgtttct 2527801 tccagccaag cgatcacttt ttcaatcgct tcctgtttgt gaaggccgtt caggaaatca 2527861 gagttcacgt gctcgccgtc gccagtatag gctgcttcct caacgttccc gccttttacg 2527921 acttccttca ccggaaggcc gaatgttttg gcgaattcaa aatcacgctc atcgtgtcct 2527981 ggaactgcca tgacagcacc tgttccgtat gatgcaagaa cataatccgc aatccaaatc 2528041 ggcagttttt ctccgtttac aggattgatc gcatacgctc ctgtaaatac gcctgtcttt 2528101 gttttcgcaa gatctgtgcg ttctaggtca ctctttgatt gaatttcttt gatataagct 2528161 tcaacagctt ctttttgctc tgccgttgtg atgttttcca ccaatgcgtg ttccggggca 2528221 aggacagtgt atgtagcgcc aaacagcgta tctggtcttg ttgtaaacac tgtaaaggaa 2528281 tcatcatgtc catctatagc aaaatgaacg tgagcgcctt ccgaacggcc gatccagttg 2528341 cgctgcatat ctttaatgct ttccggccaa tcaagctctt ccaagtcctc aaggagcctg 2528401 tccgcataag cggtgatttt cagcatccac tgcttcattg ggcgtctctc taccggatgg 2528461 ccgccgcgtt cgctcttgcc gtcaatgact tcttcgttgg caagaacagt accgagcgca 2528521 gggcaccagt ttacaggcac ttcgtcaacg taagcaaggc ctttttcgta tagctttaag 2528581 aaaatccatt gcgtccattt atagtattca gggtcagtcg tattgatttc gcgatcccag 2528641 tcatatgaga agccaagcgc ttgaatttgg cggcggaagt tatcaatatt ctgcttcgta 2528701 aacacagcgg ggtcgttccc tgtgtcaagc gcgtactgtt cagctggcag gccgaatgcg 2528761 tcccagccca ttggatgaag gacatcatag ccctgcatgc gcttcatgcg ggacagaata 2528821 tccgtagctg tgtatccttc aggatggccg acgtgcaacc cagctccaga cggataagga 2528881 aacatgtcca gcgcgtaaaa tttttgtttt tcattattat caagagtggc aaatgttttg 2528941 ttttcaagcc aatatgtctg ccatttcttt tctatctctt tgtgctgaaa actcaaagta 2529001 aaaacctcct tctgattgaa tacggcgtgt atggttcaag tattgacggg aaggagagga 2529061 ttatattcag aatattccca aactaaaaaa aactccctca tcccaaaaag ggacgagaga 2529121 ctttcgtttt cccgcggtac caccctcgtt agcgcggcat acgccgcact cacttgatac 2529181 ttttaacgca gttatgcgtc agcggctttt caccgctgca actctgaggt gagttcggaa 2529241 acaaacttga ttgactttca ccagccgtca actctctgca acaatatctg tttcttactg 2529301 ctcctcttca ttgttcttat cgcaaccgta atctaactgt attttataga attctgttca 2529361 taagtgcaag caggtttgta tacaatggga atgtaccctg aacgggcgga gattgaggac 2529421 aattattcgg gtggagtttt ggtttgacgt ttggactcgg ccggttcgcc gccgctgttc 2529481 agttctctca caaagtcaaa acttctgaga acagcttcac cgccgtagcc tgagataatg 2529541 gataagatga caagttgaat tcctgaatcg gggtcagcgg ataatacaag taaaatggaa 2529601 gccgtcatgc cgataaacca atcttccaaa aatccaaggt agataaaccg cttcgtcatt 2529661 ctgggcttct ccagcctgcc tctctttttc acatgaccga gaatccccat gattcctcca 2529721 attacacaag caatgagtac ctgatgcagc atcttcatca tcaccttcct aaagccctta 2529781 tttcgtaaag cgacttcagg ccatccagcc cccttaaacg attccgatga ttttcgatat 2529841 ctacataccg gcaaatctgt aaaaagcttg tttcttccat tatatgtgaa cacatgatcg 2529901 gtaagcttga tgcattggat tcatttttca cccagtgaca ttgacctagt cacctattta 2529961 gcatgtagaa aacctttccg ttcatatgtt caaattctgt tcttattttt agtgtatacg 2530021 aggacaagcc ctaatgacaa acaacaaact gcacttgctt gaatcagaac atgtgttgtg 2530081 ctacggttac tgtagaattc atttttaaaa aggggaatat caggctttcg catagcaagc 2530141 tgacggccta agggggattt atatggctag ttttcaatca tttgggatac caggacagct 2530201 ggaagtcatc aaaaaagcac ttgatcacgt gcgagtcggt gtggtaatta cagatcccgc 2530261 acttgaagat aatcctattg tctacgtaaa tcaaggcttt gttcaaatga ccggctacga 2530321 gaccgaggaa attttaggaa agaactgtcg cttcttacag gggaaacaca cagatcctgc 2530381 agaagtggac aacatcagaa ccgctttaca aaataaagaa ccggtcaccg ttcagatcca 2530441 aaactacaaa aaagacggaa cgatgttctg gaatgaatta aatattgatc caatggaaat 2530501 agaggataaa acgtattttg tcggaattca gaatgatatc accaagcaaa aagaatatga 2530561 aaagcttctc gaggattccc tcacggaaat tactgcactt tcaactccta ttgtcccgat 2530621 tcgcaatggc atttcggctc ttccgctagt cggaaacctg acagaggagc gatttaattc 2530681 catcgtttgc acattgacga atatcttatc aacatccaaa gatgattatt tgatcattga 2530741 tttatccgga ttggcccaag tgaacgaaca aacggccgac caaattttca agctgagcca 2530801 tttgctgaaa ttgaccggaa ctgagttaat cattactggc attaagcctg aattggctat 2530861 gaaaatgaat aaactggatg ccaatttttc gtcgctgaaa acatattcaa atgtaaagga 2530921 tgccgttaaa gtgcttccga ttatgtaaaa agatcccgct cacccagctg gatctttcag 2530981 attgttgaca aaatcctaaa atggttttca ttttaggatt ttgtcatctt ttcagcgtga 2531041 ttgaaaaccc ttgaagtcta ggaaggacga gcataggagc ggagcgaatg ttctaattcg 2531101 tgagcaccga agcgcaggcc tgacaacgaa tgcgagggtt tgtcgacacg ctgaaagatc 2531161 ccgctcattc ggcgggatct tttattatga agagattgat gcctgcttat ttgtttcttt 2531221 agctgatttt atccgtttgt catatagaag cgttgtggca atactgatca gcagcaatac 2531281 caacagagat aaaacaagag ccctaatgcc gtaatgatcg acaagcactc ctccgaacag 2531341 gggaccaatc attctgccgc ctgtcgccgc actgttgaca aagccttgat aaaagccttc 2531401 tttcccttta ggggcaagct gattggcaat agtcggcaca gcaggccaaa caagcatttc 2531461 tccgatagtc aggatcacca tcgcagcgag aaacatcgga aattgctttg cagtcagcag 2531521 catgctgaaa gacacaataa aaatgataaa gccgatgacc atttgcgctt ttagcgactc 2531581 ggcccatttt ttcaccacaa aactgacgag cggctggccg agcacaatga gaattccgtt 2531641 aaccgtccac agcacgctgt ataaggaaag agatattcca atgctttgtg tgtacgaagc 2531701 aattgtggtt gaccactgag aataagccag ccatccgagt acatagcctc cgcttaaaat 2531761 gatcagtgcg gcaaattttg ctttgctgtt cacagcatca taatcaagca cggatgtttg 2531821 ggatgcatcg cccgtttgaa tatttcgaaa tccgaaatat acaataaaga aaaagatcag 2531881 atacaatacg gcatttgcca aaaatacata tgaaaacgag aaagatgcca cgacaccgcc 2531941 aagcgctgaa ccaacggcca cgcccgcgtt ttgcgcgaca tatatcgcat taaatgcctt 2532001 ccttccccct tcaggccata ccgatcccgc cattgcgtag cttgccggaa aaacaacacc 2532061 ggagccaaag cccacaatcg tcagcagcac aatataggct ggccaatcat gaaaaaagac 2532121 aagacccatc aggcttgcta acgtaatggc tatcccaagc ataatcgatt taaaaccgcc 2532181 gattttatca aacaaaaaac ctccgcataa attgccagcc acactggcgc cggaattcag 2532241 catcaggaca agtccggcta ctgttaacga ctttcctaaa tgattatgga tataaatcgt 2532301 attcagcggc cataaaaaag aagcacccgt cacattgata aacattccaa tgactaaaat 2532361 tttaagagca cgcggcatac tcatccccct ttcttaccta aaaaagctca tgaaaaaaac 2532421 gaaacctaaa acggctccgt acgaatccag ttatcatagc acattcattc tatctgtctc 2532481 tctcacattt ttcaactgat gagcgtgaaa aaatctaaca aatattgttt gaaaaatgta 2532541 aaataaatag aaaaaggggt catattatgg aaatggtatt agcattctta ggttttctgg 2532601 catgtctcat tgcactgggc tatggattat atcaccttgt cagatatgta ctgaaaaagg 2532661 aaaaacgttt ctcaaagaga cttttttggc cgcttttcat tggaggcctt gtgctgctct 2532721 ttaccggggc agcattggca gaacctgaca ctgccgcagc aaatgccgag aaaaaatatt 2532781 cagcgctaaa cgccgaatat aaaaacctca caaaagagca cgaagaactt gagaaagaat 2532841 ataaatctgt cagctctgaa gcaaagaaat taaaagacaa caaagaagat caagacaagc 2532901 ttgagaagct taaaaacgaa aatagcgatc taaaaaagac tcagaaatca ttaaaagctg 2532961 agattaaaga gcttcaagaa aatcaaaagc agctcaaaga agatgcaaaa acggcaaagg 2533021 ctgaaaatga aacacttcga caagataaaa caaagcttga aaatcaatta aaagagacgg 2533081 aaagccaaac cgccagctct catgaagaca ctggaagttc ttcaaacaat acgagtaaaa 2533141 gtgatgaaac caaaacagct gacaaagcag aaggctgtaa tatcaaagga agcagaaacg 2533201 gcatctacca cacgccaggc agtacatact acgaccggac aaccgatccg gctgaaatgt 2533261 tttgctcagt tgaagaagct gaagccgccg gttatcgggc gccaaaacga taaacaaaaa 2533321 gctccagaat gtctggagct ttttctgttt cacaacgacg atttaatgac cttcttataa 2533381 taaagaactg acagaaaacc aaaaatggag tagagcgcag tatataacac catcaccata 2533441 atcataggcg cccatacctc tgatccgaat aagaaccagc cggattggac ggcaaagtaa 2533501 ctgtggaaga ggccgacaac gagcggaatg ccgaagttgt acatttgttt gatgcgtatc 2533561 ccctttatca ggtcgccctg cgtaaagccg agttttctta aaattgtata gctcggtttt 2533621 tcatcttcac tttcacccat ttgtttaaaa taaaggatac aacctgatgt aatcaggaac 2533681 gttaacccta agaagccgac gatgaacatc accataccaa acagtgattt ttgcgcagcg 2533741 cttgtatcta gtcttgataa atgctcgttt ttcttgttca cctgttgaaa aagctcattt 2533801 gctttttcca tttgatcgtc atgtttcaca ttgacgccga taaatgtaga ttgcgccagc 2533861 tgaatgcggg ggtctttatc cttgtccagc tgtttaaaca ggctgtcatc cacaatgaca 2533921 gcgggcatgc ccccgcttgt aaacgtgtag gacacaagaa actcttctct taatccttta 2533981 tattttaatg gctgcgtctc gtgcttgctt tttactttaa taacaccaga gtccttgaaa 2534041 accattattt tttgcagcaa gtcggtgtat cctgagaaaa cggcttctcc agccgccaca 2534101 tcgactcctt ttacatcttt gtcgctaaca acagcaagct gcatattgcc gggatcgccc 2534161 tgcatctctt tcggagttcc atccataata tttgcaatgt caacatttgc ttgcaggaca 2534221 ggtgttgcct tttttacaaa cgagatgttg ctttccctca atttgttttc aaataacttg 2534281 gcatctttct cattcatgaa tgaaaaatca gccgctacat tttgttcagc ggtcttttcc 2534341 gacgagtaat acgagatgta agcaagagat aacagcccga tggcgagcgc tgaaacggtt 2534401 gtaataatcg tcagcagcag cgcattcgat ttcattctga acatgatcga agacagtgac 2534461 agaacctcag aaatatttaa gtagccgccc ttgctttttc gaatgatatt cgagataaac 2534521 gtaactgatc ctttataaaa caaaaacgtc ccgataatga cgctccccag aatgaagctc 2534581 atcgcaacaa acagttcatt aatggtctta aattttccgc caaacagctc agaagacaca 2534641 tagtatcctg tcaaaatcaa cacgatgcct aaagcgccga tcagcatttg gaaaaatgat 2534701 attttcttca ctttgtcttc agtggaggac gttactttaa acaaagataa aatactctgt 2534761 tttttgataa acgtataatt catgatcatg atcaaaaggt aaatgccgca gaacacaatg 2534821 accgtttgga ccaaggcctg ctcagaaaaa tgcagtttcg catccgcttt gacatcgaca 2534881 attttgaaca gaatcatcaa gacaagcttc gatatcgaaa acccggccgc taccccgatc 2534941 gctaatgaac cgaaatacag catgacattt tctgcactta agatgcgaaa aattttatgc 2535001 ttcgtcattc caattaattg aaacagcccg atttctttac tccgtctctt aataaaaatc 2535061 gtattggcat ataaaatgaa gatcgccact acagccacaa gcaaaatcga agcggtttta 2535121 atagccgcgg ctcccttgat tgaagccttc acttcgttaa ttgctggatc atactgcagc 2535181 gtgacaaagg cgaaataaag cgccacgcta aagatgagcg caaacacata caaatagtaa 2535241 ttccggagat tctttttcaa atttcgcagg atgagctgat taatgttcat gctgcacccc 2535301 gcctaacacg ccttgcgttt tcataatatc ctggaaaaac gtttgcctgt cctggccccc 2535361 tttattcagc tgtgtataca tttgcccgtc cttaataaaa atgactctgc cgcagtagct 2535421 ggcagcgacg ggatcatggg taaccataat aatcgtcgcg ttgcgttttt gattgagctg 2535481 gctcagctta tttaatagat cggaggccga tttcgaatcg agcgcgccgg tcggttcatc 2535541 agcgaaaata atgctcgggt catgaataaa cgctcttcca gcggatgttc tctgcttctg 2535601 gccgccggaa atttcattcg ggtatttatc ccgcaattca tatattccca gttccttggc 2535661 aacttcctca aacttgcgat tggcttcctt ttttgatagt ttcgtgatcg ataaaggcag 2535721 aaggatattc tctttcactg tcaatgtgtc taacaaattg taatcctgaa agataaagcc 2535781 taaatgctgt tttctaaatt cagccagctg cttttccttc atagccgtca tgtcatttcc 2535841 attaatatga atggttccgt gactgacctg atcgattgag gacagaacgt tgagcaaagt 2535901 ggtttttccc gacccggaag cacccataat actgacgaat tcgccctttt caatgtgaat 2535961 atcgatgccc ttcagcactt cctgtttatt cagcttgttt ccataacttt ttcgaatttt 2536021 attcgcttct aaaatcacca tttacgcagt ctcctttata ttggataatc tcattataaa 2536081 aaggaatgcc gggcttttcc ttcgatacgg cgaacaaaaa agaaaagcat gtgacatttt 2536141 cgtcacacgc ttatgacatg ttcaaattga ttccgtattg gaaaggttaa tgtaaaaact 2536201 gttcccgcac caaactccga ctcaacatca atatggatca ataacggcgc cgctgctttt 2536261 tttgccaagt acagccccat gccagttgac gcttgatcat ggtgatccgt tgtggatgta 2536321 aaccctttat caaaaatacg cggtacatct tttggatcaa tgcccctgcc acaatctttc 2536381 acttggagct gcgtctgttc ccctttttga aagcttttga tctcgatttc agaggcttcg 2536441 ctgtatttca ccgcgtttgt cagcagctgc ctgatgataa acgccagcca ttttgcatcg 2536501 ctcagcactt ctttggcctc gagctgtatg tcaaaaccga tccctttttg gatacaccac 2536561 gattgtaaat ctttgatttc tttaaagatc aaaggctgaa gctgaatgaa ttctactgac 2536621 aggtcgtttt caataaatga aatgcgtttt tgatgaagct gctgatcaag aagcaggtga 2536681 atacgcagcc attcatatga cagctgggat ttcagtgctt tttcttccat tctatcaatg 2536741 attaaatgca tcgctgttaa tggagttttg acctcatgga tccatgccat cagctcatct 2536801 ttttcatttt ccaatgctaa gcgatgccgt gctgcggtct gcttcaagtg ttctgtttgc 2536861 ccggcaatgc ttctttcaac cattgcttca aacggcgttt ccggttcatt tatggctgtc 2536921 acatcgagat tgttctccca tgttttcaag cttttataaa acgctgtttc tttccgatag 2536981 cggaaccaaa ggaatatgat aaaaaacaag atgcacaaat acaccatata aagtacattc 2537041 ccaaatgata tggaaggatc gacaaaagca atgaacagca tcaaagcctg ctgaaacaaa 2537101 aacgcggcaa tccagctccg cctttcgata aggaatgctt taatcataga acttgtcctc 2537161 ttccttcgcg atgtagccct ggcccacctt tgtctcgata tatgcaccaa gctgcagggc 2537221 gtccagtttt tttcgcaggc gattgacatt gacggtcagc gtattatcac taacaaaacg 2537281 ctcatcgttc cacaagcttc tgatcagctc ttcccggctg acgatcttgt ttttttgctc 2537341 tattaattgt tttagaatga acatttcatt tttggtcagt tcaacagatc ctttgtcatt 2537401 gctgacgagg ttctgctccg cgtctacagc agcgccgcac cacgttttaa tcgtactcgg 2537461 ctccgtatta taatggtgca cacgccggaa catcgcttgg attttcgcga tcagcacatc 2537521 aaaatgaaat ggcttttgaa taaagtcatc tgccccgagc tgcatggaca tcaccatatc 2537581 agcaggatga tcccgggagg ataaaaagag aatcggaaca tttgaccggg agcggatcag 2537641 acggcaccaa tgaaagccgt caaatttagg cagctgcaca tcaataatga cacaatcagg 2537701 attaaccgcc gcaaattcct gcagcacctg actgaaatcc tgaatgccgt atacatcata 2537761 ggaccatccc gttaaacgat ccttgatttc atgaaacagc gattcatcat cttcaatcag 2537821 caaaagttta aacaatcgac tcaccgcact ttttcctttt ttatcaagtg tatagcaaaa 2537881 cgccagcatg cgctatagaa aaagccggct gtctcagccg gctcgttcgc attataattc 2537941 tcttctcaac gctgtcagca cgttggtttt ggtagctttt ctcgccgggt tcattccgga 2538001 aatgactgcg acccctccgc aaatcacaac ggcaatgatc acaaggctcg ccgggatgta 2538061 ggagaatgtg taattcaaat cgcccgcatc gccaccgctt gtggccgcaa gaatcatcgg 2538121 aacggccagg ttgacaaggt agctcacgcc gtaagaaatg ataatcccaa tcacacagcc 2538181 taaaattccg atatacgcgc tttccatcaa gaacattcgg cgaatgattg acgggctcgc 2538241 cccaatcgct ttcataatgc cgatctcttg cgttctctct gtcaccgcca tcgtcatcgt 2538301 gttaaaaatg ccgatcgctg aaatgataac tgcgatacat ccgacaaaga tcagtccgat 2538361 tttgaagacc atgaagaagg tattggctcc ctcaagttca gtagtcactg atgtgacata 2538421 gtacccgtca tctgttagat catttgtcag ctgttccaca ttctcaaact tatcagcaaa 2538481 aacaccaatg ttcgtttcaa catttccgcc tttgaaatct aagaattccg aaaaatcttt 2538541 tttgaattga tcactgataa aaatatttga gtcctccatc cagtcttgag atggtttttt 2538601 tgtaataccg acaattttaa agtcatatgt ttttgttttt gtaacatccc ctgttttaga 2538661 atctgtcttc gatacactta gttcaattgt tttatttaga atatctttcg tatagccctt 2538721 tggttctttt atatcttctg gatttccttt tgcttcctcg atttttttgt tatattcttc 2538781 cgattctttt ttcgttaata atctctttgc gaagtcgtat cctactacga tttcattttc 2538841 cgactttgcg actcttccct tttccaattc catattggcc tttaattcat cattcatatt 2538901 agtaaaaatg agatttgagc tttcatttgt acgattgcct aaagtagctt tgtttggttc 2538961 atacacttgc gttctttcta caactgacct tacgtgatca tacttctcta aatcagcttt 2539021 tttaatcggc ttgtctcctt ccttgcccat tacgctgact ttcgttacaa tctgctggct 2539081 cattgtcata tctgtaatcg tcttttgaat cccaaatcca acggacgaca acacaaccaa 2539141 aaacgcacac gccattgttg tcgccagaat cgtcataaag acgcgaagcc tgtttttctt 2539201 catatttctt ctgataaaat gaacctgatc cttaaacctc aacggtaatt cctcctttta 2539261 gcacaccatc atgaagctga aattttgaat gtccgataga agcgacttca tcatcgtgag 2539321 taatgatcac aaatgtaatg ccacgctcac gattcagctg ctggatcaat tccagcactt 2539381 catgttccgt ttctgaatca aggcttcccg tcggctcatc cgctaagata atcgaaggat 2539441 ttaaaatcaa tgctcgagca atactgacac gctgctgctg gccgcctgac agttcattcg 2539501 gataatgagc ggcgtggttt tccagaccga cgcgtttcag catgtcctgc accttttgct 2539561 tccgctcaga tggcttgatt ccttttaacg ccagcggcat ttccacattc tcatacgtcg 2539621 ttaaacccgg gatgagctga aagctctgaa aaataaaccc gaaatggtca agccgaaatt 2539681 gcgcccattc cttttcatta aaccccgtaa catcagtgcc attaatgaca atccgccctt 2539741 ttgtcggcga tatgtagccg gaaattaaat tcaaaagcgt tgatttccct gagccgcttc 2539801 gtccgacaat gcaggcgatt tcccctttcg ccacgctcaa tgaaacatcc ttcaatactg 2539861 gaacttcatt ctcacggccc ttttttccga tcgtgaaaga atggtcgata tgctgaacat 2539921 caatcatatg ttctctctcc cttacaaaag tttcattttt ttataaatcg caaaataact 2539981 aatcaagaaa ccgattaccg cacctgtacc catgccaatg agataaccgg caaagctctc 2540041 gcttgcagta aatccaaaat agccgaagcc catgattcct atgataataa cgatgatctg 2540101 caccgggcgg ttaagcggct tccataagaa gaaatatccg tttctttcat tagacatttt 2540161 aacaaagcta atatagccga tgatgtaaaa aatgatagtc atgatagccg gaatgactaa 2540221 ataatatggt gaattctcag cccatttcga gtctacataa attatcggaa tgaaatactg 2540281 cacccattta ggtactggac catggataaa atctattgat ccgccaaaaa ggatctcgag 2540341 gttgatcaca ggcaggctga tgagtaaaaa cggcgaaatg gccacggtaa atgagactag 2540401 aagctgtgcg aaactattgc ctgtcaaagc tcctccggcc ataaccaaag aataagccag 2540461 catgctaaca ataatcattc ccaagctgta attgtgaaaa taaacggcct gatctggctt 2540521 caaaagcatg atcagcaaaa cagacaaaac ataacctatg agctgcggca ccacaatcac 2540581 cattccgccg gtaaggaact tcgcatgaaa tatctgccct cgtgtatatg gaaggcttaa 2540641 tgtaaaatca aagaagctct tgctacgttc aatcccaagc tggctgaccg ccaaaacgac 2540701 tccccaaatc caaaacaatg agataaatga gctatttaaa taatcaacgc tgaatacgca 2540761 ggggccgacc caattttctt ttccagtgac acagccttga tagatgagat acatatttaa 2540821 aattgataat ggattaccta atataaaaac caaaatggtg ataactaagg cgactttatt 2540881 ctgccgccac tctttgtaaa gcagtccgga atccggcaac tcacttccct ccaaacctaa 2540941 ggcatttctt acacttttgt tttcttataa atagagaagt agctcacaaa gaatccagcc 2541001 actgctccaa tgatcatacc caaaatataa ccaataatgg aatgtccggt atagtatcca 2541061 aataaaccaa atccaaggat gccgaaagcc ataaccagaa tttgcaccgg gcgatctaat 2541121 ctgttccata agaaaaagtg tccgttccgt tcacttggaa gcttcttgaa gcttataaag 2541181 ccaatcaagt aaaatagcat gctcattacg gctggaatca ataaaagata tttactgtta 2541241 atcagccatt catttacaac gtaactaatc ggtactaggt tcgataaatt gcttgccaga 2541301 gagaaataac tctcagggga agggaatatt tcccatatat tcgcaccaaa aacaacttct 2541361 aggtttccaa ccggcaatgc aataattaaa tacggcaata tagctgctga aaacgccgtt 2541421 aacagttggg caaaagcatt tccagttaac gctccggcgg ccatcaccag tgaaaaagcc 2541481 ataaaactta tcacgattac tccaatgctg ctgtgctcaa aaaagtagac gtgttcaggg 2541541 ttatagacaa gaatcagcag ccatgcaagt aaaaagccaa tcaattgtga cagcacaatc 2541601 acaaaaccgc ctaaccaaaa ttttgtctga aaaatttggc ttctgttata cgggaggctt 2541661 aatataaaat ccatcgtgcc tttcgaacgc tccattccga ggaagcagac cgccaaaatg 2541721 acacccggca cccagttgat atctatcaga ttgcttatgg aataattcac aataaaatca 2541781 caatattgcg ggtcttggcg atcaagacac ccttgataag acaaatacgt attaacgata 2541841 gaaagcggat ttgccaatac taaaaacgcg atacttaaca aaatcaccac ttgattctgc 2541901 ttccactctc gatagaggag acctcggtct accatctccg cttccctcca aacttcgcaa 2541961 tgaacacttc ttccaggttg acaggaagct cattccacac ttttggcttc agctctctca 2542021 aaaagctctt tttctcctca tcgcttttcg gaatcagcac tgtgtaaaac acgccggcct 2542081 gatcgagcat cggaatgttt tgctctctga tggccaaatt gacatctgta tcgaaggcca 2542141 tttgaatttt aatgtattct tcttttaact catcaagatc catgacgttg gtcaggctgt 2542201 tatcttcaag aaaaccaatt cggttgcaca tccgctctat gtcttcaagc cggtgggacg 2542261 taatcaggat gctcgtatca cgctctgcca cttcatcgac catcagctgc agcacatcat 2542321 gccttgtcac cgcatcaata ccatccgtcg gctcatcaag gaggatcagc gccggtctcg 2542381 ccgcaaacga cagaacgagc gatagctgct tttttaagcc tgtcgacagc tcacggtatt 2542441 ttttcgtttc cggaatttcg tatctgttca tcagctcatt cgcgtacgtg acatcaaatt 2542501 tcggatatat tcttctcaaa atatcgacta actgcttgta tgtatactta tcgtaaaacg 2542561 gattttgaac aggcatgtag atgatatttt gtttgacttt cgggtgcttt ttgatttcta 2542621 cgccgtcaaa taaaatcgtt ccgctgtcag cgaaaatgat ttgctggatt aagcgaagca 2542681 tcgtcgtttt gcccgatcca ttgcgtccaa gcaatccaaa gatttctcct ttttcgattg 2542741 ttaatgaaac atcttttaat acttgattgc cgtcaatcgc ttttgacagc tgccgcagtt 2542801 caatcatttt ttttgcctcc cttcacatca gcgctgattt cctttatcca ttcgtgcagt 2542861 ttttccagct caacccctgc atagtgtgca tcgatgatga gctgtttgag ttgctcttta 2542921 atcatcgtca tcttcccttc aaccagtgtc gtttttgcat tctccgatat ataggtccct 2542981 ctgccccgca gcgtttcaat aatcccctct cgctcaagtt ctttatacgc tttgctgaca 2543041 gtgttcggat tcgcaataat gatcgttgcc aattctctga cagaaggaag cttatcacca 2543101 ggcttcatga tccctttcaa acaaagctct ttcatttgct gaataatttg ttcgtaaatg 2543161 ggtgttgagc ttcttggatc gatttgaatc atttacttcc ctactttcta tacgatctga 2543221 accttttata gataaaaatg atcaattata cttttttgcc attcaaaacc gatcatcaca 2543281 agaacaagaa aaaaagaaca agcgatcaca gatgccgcaa tcagcattgg cacgttacgt 2543341 ttgtttcgtt ttttatgttt cataactgcc tcccttaatg tcaatatata aatgatttta 2543401 tattagtgtc tatagtgtat tacttcaatt agtacactta atacaataaa tactttgact 2543461 cacaaagtca atcctttttt tacaaaaaaa cggacccttt taaaagggtc cgttttccta 2543521 cacatcaaga gggtgctgca ggatcatatt attttgcaaa gattgaagct gaagtctcat 2543581 tctgtacagc tgttctctct gctgatcatt tgacgacagc catagtttat tcaaggcatt 2543641 taccgcatct tctagctgca tttgtgcatc actatattct tgatcgttat aatgctcttg 2543701 tttagaagcg attttcagct gttcttcagc ataatcatag gcctgcatac attgctggag 2543761 atgttcatct actgattgtc ttgttgccac agtaacccct cctcttggta atggaaatca 2543821 tccatcattc atattgtagc ctcatctgac tttattcaat aaagtaattt atggtcgata 2543881 ttcatttgtt ctcttgtgaa atgcgtgcta caattttagg atgcaatcgt acgcaaggag 2543941 gcacatgaat tgtgatgcag aacaatcctt ttccttattc aaatacggaa aaacgctatc 2544001 atacattgaa ttatcatctc agagaacatt tcggccataa ggtgtttaaa gtagcgcttg 2544061 acggcggttt tgactgtcca aatcgggatg gcaccgtagc ccacggaggc tgtacgtttt 2544121 gcagcgcagc aggctccgga gattttgctg gaaaccggac cgatgattta attacgcaat 2544181 tccatgacat caaaaaccgc atgcacgaaa aatggaagga cggcaagtac atcgcttatt 2544241 ttcaggcttt cacaaacact cacgccccgg ttgaggtgct tcgtgagaaa ttcgaatccg 2544301 tcctcgcctt agatgatgtg gtcggcattt cgatcgccac acgcccggac tgtctgcctg 2544361 atgatgtcgt tgattacttg gcagagctga atgaacgtac gtatttgtgg gtggagcttg 2544421 ggcttcaaac agttcatgaa cggactgcac ttttgatcaa ccgcgcacat gattttaact 2544481 gctatgtgga aggcgtcaat aaattaagaa aacacggcat acgtgtctgc tcgcatatta 2544541 tcaacgggct gcctttggaa gaccgggaca tgatgatgga aacggcaaag gccgtcgcag 2544601 atttggatgt ccagggcatt aaaatccatc tgcttcacct actgaaaggc acgccgatgg 2544661 tcaaacaata tgaaaagggc aagctggaat ttctttctca agatgattat gtgcagctcg 2544721 tctgcgatca gcttgagatc attccgcctg aaatgatcgt ccaccgcatt acaggtgacg 2544781 gaccgattga gttgatgatc gggccaatgt ggagcgtcaa caaatgggaa gtgcttggcg 2544841 ccattaataa agagctagaa aatcgaggca gctatcaagg aaagttcttt caacggcttg 2544901 aggaggaatc agcgctatga ttttgaagaa aattcttcct tacagcaaag aactgctgaa 2544961 aatggccgcg ggagagggag atattgtcgt agatgcgaca atgggcaacg gacatgatac 2545021 acagttttta gcggagcttg tcggtgaaaa cggccatgta tacgcattcg acatccaaga 2545081 atcagccgtg gccaatacaa aggaacggct cggtgacatg tatcaagcgc gaacaacgtt 2545141 atttcacaaa agccatgata aaatcgctga atccctcccg cctgaaacac atggcaaagt 2545201 ggcggccgcg gtatttaacc tcggctattt gccgggcggg gacaaatcaa ttacgacaaa 2545261 cggcagttct acgatcaaag ccattgaaca gcttctcagc atcatgaaag acgaaggtct 2545321 gattgttctc gtcgtctatc atggccaccc ggaaggcaaa gctgaaaaaa acgacgtgct 2545381 cgagttttgc cgggacttgg accagcaaac agcccgtgta ttaacatacg ggtttatcaa 2545441 tcagcaaaat gacccgccat ttattgtcgc catcgaaaaa aaagctcaga tcagcaaatg 2545501 atttgagctt ttttctttga atttttcatc caggacattt tttgaaattt ccggtaggct 2545561 ctgccgttga tataaaagaa aagggaggtt tttccgctgg ctttgatcag cttctttgcg 2545621 agccggacct gcttcgtctt actttaccat ttttcaaatt atatttgaaa gcaataacca 2545681 tcgttaaccc ggacgtcata cagttcgggt ttcgattttt ccataaaacg ttcacatata 2545741 gcatgaaacg tatgactttt atcttatcac aaaactataa acagcctctg caaaaacaca 2545801 tacctattct ttcctgttct ctattttcta tgagcacaca caaaaagagc ccactgggag 2545861 ctctttttgt cagctgatat ttcgttcgct ggcagcagcc gcattttttt tatgaaaccc 2545921 ttttccatag tacacagcca gcaagatgag aaaccatatc ggcccgataa tcacggctac 2545981 tcttgtatca gggctgtaag ccataagaat gacgacgaat gctagaaatg ccaatgacac 2546041 ataagacgta aacggaaata aaggcatttt gtactttaat tgtttctttt cttccggctt 2546101 caaacttttc ctgtatttta tttgagaaag caaaatgatt gcccacgtcc aaatcgctcc 2546161 gaacgtcgca atacttgtaa cccaagtaaa taccttcgca gggacaacat agtttaacag 2546221 cactccgact aataaagcgc ccgctgaagc cagaacagct ttacccggga tgccgccttt 2546281 cgtcagctga ccatatgctt gtggcgcctc tttctgttcc gccaagttaa acagcatccg 2546341 ccctgtgctg aaaataccac tgttgcatga agacagcgcg gctgtcaaca cgacaaagtt 2546401 aatgatacct gcggccgatg gaatgcccac tttttgaaat gtgagaacaa atggacttcc 2546461 ttgagagcca atttcctgcc acggataaat agacataatg acaaataaag cgcctacata 2546521 aaaaatcaaa atccgccaaa atactgtatc gattgctttg gctaacgatt tttgcgggtt 2546581 ttttacttcg ccagccgtca ccccgatcat ttcaatccct aaataggcga acatgaccat 2546641 ttgaagagac aataaaaccc cttttaatcc atgagggaaa aatcctccgt tgttccacaa 2546701 attgctgatt ccggttgcaa tgcccccatt gccgactcct gcaataatca tcaataaacc 2546761 gacagcaatc atggataaga ttgcaacaat tttaatcaat gcgaaccaaa attccagctc 2546821 gccgtaagct ttgacagcca ggaaattaac acccgtcata atgaccagtg ccgataacgc 2546881 ccaaatccag tttggcacgt ccggaaacca gaaccccata tagatgccga cagcagtgat 2546941 ttcggccata caggtgacaa cccataaaaa ccagtagttc caacctgtta aatagcctgc 2547001 aagcggtccc aaataatcac gcgcatacct gctgaaggag cctgcgaccg gtttttgaat 2547061 ggccatttcc ccaagcgctc tcataataaa aaacatgacc aggccgcttg cggcatacgc 2547121 taccaaaata ccaggccctg ctaattgaat agctgatgcg gagccgagga acaaccctac 2547181 tcctatagca gctcctaaag acattaaaga aatatgcctt tcttcgagtc cgcggtgcag 2547241 ctcttgtttt tgtttttgca tgcttcttct cccctagaaa aaaatatcat tatatcattt 2547301 ttctgaatat tccgtacgga ttgggtaaat caatgatgat ggagaaataa aaggataaca 2547361 acaaggcttt cgactactcg aaagccttgt tgtctgttac acaaagatga cttctttagg 2547421 ctgatggctc agctcttcag gcatataccg tttttcaata ttgatgctgt gccagatcat 2547481 aaagattagc acagtccaaa ttttacggct gttatcagcc ttgtccgcac aatggtcttc 2547541 aagaagctga aggacataat ccttatggat ataagcatcc gtttggcttt cttgaataat 2547601 attccgcacc cattcgttca tttcgttttt cagccaatga cggatcggta cagggaaacc 2547661 aagctttttg cggtttaata cgtgctcagg cacaattcct tcagcggctt tgcgaagaag 2547721 atacttcgtc gtgccgttct tcgttttcag ctcatcagga atttttgaag cgacgtcgaa 2547781 tacgacttta tccaagaacg gcacacgcag ttccaaagaa ttcgccatcg tcattttatc 2547841 cgcctttaac aaaatgtcgc cgcgcatcca agtgtggata tcgacatact gcattttgtt 2547901 gatatcgctg tacgagctgc tttctgtaaa gtaagtcttc gtcacatcgc gatatgaaag 2547961 gttcggatta taatgcttca acagctgctt tttgacagac tcttcaaaga ttttcgcgtt 2548021 accgatataa cgatcctgaa gcggagtgca gccgcgctca agcaggctct tccctctcat 2548081 accttcaggc ataacggcag caacgtgcag aagcatcttt ttcaagccgg acggaatccg 2548141 ttcaaacggt ttaagcgaaa gcggttcacg gtaaatgtta tatccgccga agagctcatc 2548201 cgctccttca cctgataaag caaccgtaac atgttttttt gcttcttttg caacaaagta 2548261 caacggaatc gctgccggat cagcaagcgg gtcatcaaaa tgccatacga tcttcggaag 2548321 ctcattcatg tattcctcag gcgaaatgac tttgctgata ttttcaatgc ccagcgccgc 2548381 tgccgtttct ttcgctacat caacctcact gaagccctgc tgttcaaagc cgacagagaa 2548441 tgtttttaag cttggatgaa attccttcgc aacagacaca ataaaggaag aatcaatccc 2548501 gccagacagg aacgaaccga caggaacgtc acttctcata tgaacgttta cagagtcata 2548561 gatcgcgtct cggacttctt tcacaagctt gtcttcttca gtctgaaccg gcttgaagtt 2548621 cgctttgaaa tacgttttga atgtgatatc gccgtccggg cggattgtga attgtgaacc 2548681 cggctctact tttttcacat gggcatcaag cgtgcttggt tcaggaacaa attggaaaga 2548741 catgtactgc tgcaatgcct ctttatctat ttcaatatca ttctgagcaa ccattaaact 2548801 ttttctctct gaggcaaaat aaacctgatc attgatcgtt gtgtagtaca acggtttaat 2548861 gccgaatgga tctcttgccc cataaagcac atgatcgttt ttattccaaa tcagaaaggc 2548921 aaacataccg cgcagtttgg acgccgcttc ttctttatag tgacggtaag tcgcaagaag 2548981 aacctctgtg tccgaatccg tgttgaatgt gtaccccttt gcttcaagtt cttctctcag 2549041 ttcgatatag ttatagattt ctccgttaaa gataatccaa tatgtttcat cttcatatga 2549101 taaaggctgt ccaccatttt ctacatcaat aatgctgagc cgtctgaatc cgaagccgac 2549161 gtgctcatca tggaaatatc catcactgtc aggaccgcgg tgaacgatca tttggttcat 2549221 ttgtttgatt agttcttctt gatcagcggt ttgagctaac ggatgcttgt taaaaacccc 2549281 gacaaatcca cacatagtat tgcctccata attaaaattg tcatcattga acccctattt 2549341 atagacgctg tgaatagtat ttggtttcac agttatgtaa aaaaataaac atgaatacaa 2549401 cgataaaaaa gggaaagccg cttaaccagt aagcggctat aaaattattc tcctaacgct 2549461 tctttacgca gctgctccgc tttgtctgtg cgctcccatg gaaggtcaac atcgtgacgt 2549521 ccaaagtggc cgtacgcagc agtttgttta tagatcggac ggcgcaaatc aagcattttg 2549581 ataatgccgg caggtcgtaa atcaaagtta ttgcgaacaa cttcaatcag tttttcctca 2549641 gaagcttttc ctgaaccgaa tgtgttgatt gagattgaca caggctgtgc aacaccgatc 2549701 gcgtaagcaa gctgtacttc gcaagaatca gcaagctcag ccgcaacgat gtttttcgca 2549761 acgtatcttg ccgcataagc tgcagaacgg tctaccttcg tcgcgtcctt acctgagaac 2549821 gcgcctccgc cgtggcgtgc atagccgccg tacgtatcaa cgatgatttt gcgtcctgta 2549881 agtcccgcat ccccttgagg gcctccgatt acgaaacgtc ctgtagggtt gatgaaatat 2549941 tttgtttctt catcaatcag ctcttcagga acaaccggat tgattacatg ttctttaatg 2550001 ttgcgctgaa tttgctcaag tgtaatttca gggtgatgct gagttgaaat aacaatcgcg 2550061 tcaatgcgga ctggtttgtt attttcatcg tactcaaccg ttacctgtgt tttgccgtca 2550121 gggcgaaggt acggaagaat atcttcttta cggacttcac ttaggcggcg ggctaattta 2550181 tgggcaagtg aaattggaag aggcataagc tctttcgttt cgttgcacgc ataaccgaac 2550241 attaatcctt ggtcacccgc accaatcgct tcaatttctt cgtcgctcat tgtgccttca 2550301 cgggcttcaa gcgcttggtc tacgcccatc gcgatatcag cagactgctc atcaattgat 2550361 gttaaaaccg cacaagtttc cgcatcaaat ccgtattttg cacgtgtgta tccgatttct 2550421 ttaatggttt ggcgaaccgt tttcggaatg tcaacatacg tagaagttgt gatctctccg 2550481 cttacaagaa ccaaacctgt tgtcacagat gtttcacaag caacacgcgc gttagggtct 2550541 ttctttaaaa tttcatctaa aatgctgtca gaaatctggt cacagatttt atccggatgc 2550601 ccctccgtaa cagattctga tgtaaataaa cgacgatttt tactcatgat ttgcttcctc 2550661 ctgcacaagg cctcccgaaa gaccttgtat atatgatacg gaactcgctc cctcttatac 2550721 aatgtacagt tatattagag aatgttaatt ggcatattta tgaaataaaa aaaccttttc 2550781 catcgaggaa agggtttggt ctttgtgcct ttcactctta tcgctcaagg aatcatacaa 2550841 ccttgcaaca ggttagcacc ttggttgtct cactcagttg aacataataa ataacagaga 2550901 aaccggttgc tgggcttcat agggcctgtc cctccgccag ctcgggataa gagtatccgc 2550961 tcaatgaaat atcttatcgt aaaagggttt gcaatgtcaa tatgattcag aagaaatagg 2551021 cacctatatt gagggaaaac aatggaaatg cacacacaaa aaacaataaa tagtatagac 2551081 tatttgaaaa tatatgttat actaattcac aattagcaaa acacaaaaaa cgataaagga 2551141 aggtttcata tgaactcagt tgatttgacc gctgatttac aagccttatt aacatgtcca 2551201 aatgtgcgtc ataatttatc agcagcacag ctaacagaaa aagtcctctc ccgaaacgaa 2551261 ggcattttaa catccacagg tgctgttcgc gcgacaacag gcgcttacac aggacgctca 2551321 cctaaagata aattcatcgt ggaggaagaa agcacgaaaa ataagatcga ttggggcccg 2551381 gtgaatcagc cgatttcaga agaagcgttt gagcggctgt acacgaaagt tgtcagctat 2551441 ttaaaggagc gagatgaact gtttgttttc gaaggatttg ccggagcaga cgagaaatac 2551501 aggctgccga tcactgtcgt aaatgagttc gcatggcaca atttatttgc gcggcagctg 2551561 tttatccgtc cggaaggaaa tgataagaaa acagttgagc agccgttcac cattctttct 2551621 gctccgcatt tcaaagcgga tccaaaaaca gacggcactc attccgaaac gtttattatt 2551681 gtctctttcg aaaagcggac aattttaatc ggcggaactg agtatgccgg tgaaatgaag 2551741 aagtccattt tctccattat gaatttcctg ctgcctgaaa gagatatttt atctatgcac 2551801 tgctccgcca atgtcggtga aaaaggcgat gtcgcccttt tcttcggact gtcaggaaca 2551861 ggaaagacca ccctgtcggc agatgctgac cgcaagctga tcggtgacga tgaacatggc 2551921 tggtctgata caggcgtctt taatattgaa ggcggatgct acgctaagtg tattcattta 2551981 agcgaggaaa aggagccgca aatctttaac gcgatccgct tcgggtctgt tctcgaaaat 2552041 gtcgttgtgg atgaagatac acgcgaagcc aattatgatg attccttcta tactgaaaac 2552101 acgcgggcag cttacccgat tcatatgatt aataacatcg tgactccaag catggccggc 2552161 catccgtcag ccattgtatt tttgacggct gatgccttcg gagtcctgcc gccgatcagc 2552221 aaactaacga aggagcaggc gatgtaccat tttttgagcg gttacacgag taagcttgcc 2552281 ggaaccgaac gtggtgtcac gtctcctgaa acgacgtttt ctacatgctt cggctcaccg 2552341 ttcctgccgc ttcctgctca cgtctatgct gaaatgctcg gcaaaaagat cgatgaacac 2552401 ggcgcagacg ttttcttagt caataccgga tggaccgggg gcggctacgg cacaggcgaa 2552461 cgaatgaagc tttcttacac tagagcaatg gtcaaagcag cgattgaagg caaattagag 2552521 gatgctgaaa tgataactga cgatattttc ggcctgcaca ttccggccca tgttcctggc 2552581 gttcctgatc atatccttca gcctgaaaac acgtggacca acaaggaaga atacaaagaa 2552641 aaagcagtct accttgcaaa tgaattcaaa gagaacttta aaaagttcgc acataccgat 2552701 gccatcgccc aggcaggcgg ccctctcgta taaaaaacaa aagccaagag caattatgct 2552761 cttggcttgt tttaattgac ggaatgcaaa gaagtcagct tgtatgtaat gatggtccgg 2552821 ccttcttccc attgaagctt ctgcacttca gctgtgcctg acttttcgcc aaactttgtt 2552881 ttgcgtacat ccattggaat ctccatcgga tatactcggt atccgtcctt ctctaacgtg 2552941 aatatatttt catctatgcg aacttctttt ccttttgtca caatcagtgt attaaattca 2553001 acaggcattc ccaaagtgaa atcccctttc gttctctttt ttctttatca taacatattt 2553061 cactgtcagc ggtttttcat ccattgtgtg agctgccgca cgatacgccg gttttctttt 2553121 ggcgggaaat aatgtgtgaa tgtactgtag taccatgttt ccaccggctt atgcagttgt 2553181 tttagcttct cttctaataa ataggaatgc tgaatcgaaa cattttggtc tttttctcca 2553241 tggattaaca gcacgggagc ctgaattttg tttacttggt caaacggtgt cctccattga 2553301 tattcctcag gcaccttttt cggtgttccg ccgatgactc ttttcatcat tcgccgcaaa 2553361 tcctgccgct cctcgtatgt aagaatcata tcactgacgc ctccccagga aacaaatgaa 2553421 gctgcctgcc cgcccatttc gatcgcagtg agcattccca taattccgcc gcgggaaaaa 2553481 ccgaagatat ggattctatc cttcttgaca tttgggtgct gctgaagcag gcgaaaagca 2553541 gaaaatgcat cctccctgtc ttctccggca aaatcctcat tgccttctcc tccttgattg 2553601 cctctgtaaa aaggagcaaa caccacaaac ccttgggatg caaactggat aatccggccc 2553661 ggccgaacca tgcccacgct tttaatcccg ccgcgcaaat ataaaaatcc gtcatattgt 2553721 cccggttccg ccggctcagc cagaagcccc ttaacccgta atccatttga cagatagcag 2553781 atcgtataca aacgcacatg ctggcttggc gacggaaatc ttcttttctc tacaatcaaa 2553841 acagccgcct ccttttttct atatgctttc cttactccaa aattacatcc ggagaacctg 2553901 gttaggcatt cacacatttt tatacccatc atacgatatg taaagcaaaa aaggatatta 2553961 acttgatgcg aaataaggag gttgtctatg tgaacagatg gttaaggctg ggcttcgcct 2554021 gtgtcggcag tatctttctg atgttcgccc tggcggcttg caagcaggaa gaaacgctca 2554081 ccaaagtcaa agtagctgaa gtgacccatt caatttttta cgcaccttta tatgttgctg 2554141 agtctaaagg tttttttaag gaagaagggc ttgatgtcga tgtgaatacg acctggggcg 2554201 gagataaaac gatgacatcg cttctttcca acggctccga catcgcgctt gtcgggtcag 2554261 aaacatctat ttatgtcgaa gcgcaagggg ctaaagatcc cgtcattaat ttcgcccagc 2554321 tgactcagac agacggaacg tttcttgtcg cgagagaaga tgttgaacac ttcgactggg 2554381 atcagctgaa aggaaaaacg tttctcggtc agcgaaaagg cggcatgccg caaatggtcg 2554441 gcgagtatgt actgaacaaa cataagattg acccgcataa ggatatagac ctcatccaga 2554501 acatagactt cgccaatatt gccaatgcgt ttgcttctgg aaccggtgag tatgtacagc 2554561 tctttgaacc gcaggcttct ctctttgaga aaaaaggcat cggccatatc gtggcttcat 2554621 tcggagaaga atcaggagag gttccttata cgacttttat ggcgaaacaa agctatttga 2554681 agaaaaatga agacacagcc gtcaagttta caaaagccat ttataaggcg cagcagtggg 2554741 ttgaaaatca ttctgcgaag gacatcacag atgccattaa agatgaattt gatgataccg 2554801 acccagacgt catcgaaaca tccattgaac gctataaaaa acagcattca tattcaccag 2554861 accctctgct taacgaaaaa gaatgggagc ttctccaaac cattatggat aaatcgggag 2554921 aactgccgaa gcacattcca tacaatcagc ttgtaaataa agaaattgct gaaaaagtca 2554981 cctcggagaa ataggaggcg ccatctatgt ctttcttaca tgtcgaccat gtaacccata 2555041 cttatttttc tattaaagaa aaaacaacgg ctgtgcggga tattcatttc gatgccgaaa 2555101 aaggcgattt catctcattt ctcggcccaa gcggctgcgg aaaaacaaca ttgctttcca 2555161 ttattgccgg tttgattgag ccatcagaag gcagagttct gattgaaggc cgtgagccga 2555221 atcaaaaaga acataatatt ggctatatgc ttcagcagga ttacttattt ccctggaaat 2555281 ctatcgagga aaatgtgctt ctcggtttaa aaatcgccga cacgctgaca gaagaaagca 2555341 aagccgctgc actcggtcta ttgccggagt tcggcctcat agatgtggag aaaaaatatc 2555401 cgaaagaact gtcaggcggg atgcgccagc gggctgcgct tgcaagaaca cttgcgccta 2555461 accctagtct gcttttgctg gatgagccat tttccgcgct tgattttcag acaaagctgt 2555521 ctttggaaaa cctggtattc cgcacattaa aggaatatca aaaaacagca gtgcttgtca 2555581 ctcatgatat aggggaagcg atagcgatga gcgatacgat ctttttattt tcaaatcagc 2555641 cgggcaccat ccatcagatt tttaccattc ctaaggaatt ggccgcgatg ttgccttttg 2555701 acgcccgtca ggaaccttcc ttccagacac tgtttcaaac gatatggaag gagctgaatt 2555761 ctcttgagaa acagcaaaga aaccattgat ctgcttcacg agcagtatca attcaaacag 2555821 aaaaaggaaa agtggaaggt ccattccttt cagcttgcca tatttattct ctttttctcg 2555881 ggctgggaaa tctccagcag gcagggctgg atcgatccgc tgatcttcag ctctccatca 2555941 gctgtgtggc gattattgct ggagaaactt ggtgacggtt ctttactgtc acacatcggc 2556001 gtcactttat ttgaaacggt gcttggcttt ttgctcggga cgtttatggg cacgtgccta 2556061 gccgctttgt tatggtggtc taaccgactt gccagaattt tagatccgta tcttgtgatt 2556121 ttgaacgcaa tgccgaaagt ggccctgggc ccgatcctga ttgtcgcgct cggtcccagt 2556181 tttatcagca tcattgcgat gggagccatc atcagcgtca ttatcacaac catcgttgtc 2556241 tacaccgcct tccaagaggt cgacgaaaac tatacgaaag tcatgaaaac attcggcgca 2556301 aaaaagtggg ttatttttaa agaagtcata ctgcctgcat cctcccccgc gattatttca 2556361 acactaaaag tgaacgtcgg tttatcatgg gttggcgtta ttgtagggga attcctcgtt 2556421 tcgaaggtcg gattaggata tatgattatt tacggattcc aagtcttcaa ttttacactc 2556481 gtcttcttaa gcctgctgat catcgccatc ttcgccactc tgatgtatca gggcgtcgag 2556541 ctgctggaaa agaaatggac gaaggggagg acataaaaaa cccggcacat gtgccgggtt 2556601 ttttattcaa tccatccaga ttctttcagt tttttcaagc tgatcggaag aacggaatcc 2556661 ttcataataa agctgaattt tttattgcgg gaaaggttct ccggcagctc gtgaaacaaa 2556721 accgggcctt tcgtttcaaa gtaatcagcc tgcttttcaa gcttttctat atctgcaaaa 2556781 tatatatttt ttacaatcac tttttctttt ccgagaactt tatactgtcc gagatacttg 2556841 aggcttttga ctctcgcgcc cgtctcttcc tttacttccc ggagcgcagc ctcttctgcg 2556901 cactccatcg gctctacttt cccgcctgga aactcatagc ctctgtcctc atgttctgtt 2556961 aaaagccatt tgccgccaaa acggcaaatc acccagacat gcttcgggct gtccgagaaa 2557021 ggctgatcgt caaaggaaag ctgaacagta ttctgataat aatctttaaa ctcgtacatg 2557081 tttatccctc aaatccgttc ctagctatct tccatacatc ataccacagt tacgtttctt 2557141 cggaagcctt ttatcaaaaa ataagggaaa cccagcacgc cgtcaggttc tgcatgcaga 2557201 ctagctcgta cagttttttt gcgatacttt tgccggaaag tgcgaccgac gctctgggct 2557261 ttattatgac ccgcgaacag ggaaaagtta cggtttgcgc ttaaatttat tttttaacgt 2557321 ttctaaaaga tcgacaagca tctgaggaac cggtatgcca agagagctgg ctgtcacaac 2557381 aatttgcaca gattcataaa gaatataaaa cataatagcc aagtcacgaa ttgatccctg 2557441 tgtattcagc agctgatcaa aaaagtggca tacagagatc agagccagcg tgactaattt 2557501 tttgacaagc cgggcaaata cctttttaaa tgacagtttg tgaataatgg tttccttcaa 2557561 agtcgtactg ataaattcaa ttgccataag agagagcaaa atcagaaatg aatactgaaa 2557621 acctccaaag aaaaaacccg ctgctgaaac gctgactgct aaaaacgaaa agatgccaaa 2557681 gtctctatcc atttatccca acatcctttc acagaaacgg ccttacgata ttctatggta 2557741 aacaagccga acggattgga tttttcagaa aaatggactg gttgtcgcct atttttcaga 2557801 tacaaaaaga aaagccggac gtctttttta agacatccgg ccgttctatt tttgaactta 2557861 acctaggtaa gcttttagca tccagttatg tttttcaata ttttgatgga tcgcaagaag 2557921 catgtcccct gttgtttcgt caccgacttc atcagctaaa tccatgccgt ttttcagctc 2557981 ttccgcgatg actgtgaaat catcatatac gctttgaacc atttgttcag ctgtttcatt 2558041 tccagcagct tctttgacag aagccgtttc taaggattcc ttcattgttg caatcggttt 2558101 tccgttcagc gccaaaagac gttctgctaa gtcatcaata taagttgctg tttcgttgta 2558161 cagctcctca aacttttcat gaagagtgaa gaaatctttc cctttcacat accagtgata 2558221 attatgtagt ttcacataca tgaccgtcca gttggctact tgtttgttca ctgcttgaat 2558281 caattgttct gacatggtat ctcctccttg ttatatgact atgtataccc ttaatatcgt 2558341 acgctaaaac ctctttttta cccttatctg tcacgatttc ttctattatg ctacaattgt 2558401 taaaaaacgg gaggtggaat gtcatgacgc ttctcattac gataagtatt ttgattgtgc 2558461 tggctgtttt gcttgtaacc atttggacga ctgtaaaagc ctataatgta aagcatacca 2558521 ttgatccacc acaagaaaat cactctgatt cacacaatca atgatgatgt gaatgctcct 2558581 cttctgactg attgctggca gcatcggcgt ctccgacttg gacttttaag gtcggcatgc 2558641 tatgctgttt ttttgctgtg acatgagatt ggacagtgta tacaccatct tccttaaacg 2558701 tcgtttccaa tcggtatacg cctttttctt gtttcacctt aaacatttgg cttgcgtctt 2558761 tttccccttc tttccatact tcaaactcta cttcatcggc atccgtcaca gcttcatcac 2558821 catatgatac agctgcttca taagcagcgc tttctccggg atttactttt tcaggcccgg 2558881 tcagcttgac atccaaaacc tcgggcgtct cagctgtatt tgctttactt tcaccagatc 2558941 cgcatccatt aagcaataaa gcagaaaaaa gcagaacaac caacatcttt ttcatgccat 2559001 caccctttca tcgtttacct aaatagtagc aaacgcttac agcaaatggt acacaaaata 2559061 tgagacgtca caaaaaagac ctttttgctt aagcgcaaaa aggtcctttc tattttagcc 2559121 aaatactttt agcaattctt ctttatcctg tgaaagccag aaacgcatta aacgtttagc 2559181 gccttccaga tcatgaagct tcgcttggcc gcactgcttt tcattcgcag caggtatttc 2559241 tgtaatctct accgcttcct tcattgtgtc ttcaagcaga tcaacgattt ccgctgatgt 2559301 cggctctccg ctcacaacta gataatagcc tgtctggcag cccattggag aaatatcaat 2559361 gatatcaaaa tgatcgtatt tctcagcgtg agaacgaatc gtaaacgcga gcaaatgctc 2559421 gagtgtgtga atggtgtcag gcttcatcgc ctgtttattt ggctggcaaa aacgaatgtc 2559481 aaatttattt acaacgccgt ctgttcccac tttatgcacg ccgcaatgtc ttacatatgg 2559541 agcaacaacc gcattatgat caagctcaaa actttctact gaaggcataa tggcactctc 2559601 ccctttttta aaaatgtaat ttcattataa catacttttc cgataagaat tattgattaa 2559661 cttttcaatc tgtgtttttt ttcttatact tgcatcagaa aggttgctga agaaacatga 2559721 aaaccctatt catcgctctg atcagaggat atcaaaaatt catctcgccc ctgacaccgc 2559781 caacgtgccg cttttatccg acctgttccc aatatggaat cgaagcgatt aaaacacatg 2559841 gcgctttaaa aggcggatgg ctgacaatca aacggatttt gaaatgccac ccgttccatc 2559901 cgggaggagt cgatcccgtt cctgaaaaga aacaaaaaca ttaattgtta taaccgttta 2559961 cgataagatc cagttttccg gttttaggat caatgactaa gccatggacc ggaacgtttt 2560021 cagggaacag cgggtgatgt ttaataacat ctacgctgtc tttcacactc gcttccactg 2560081 aatcaaagct tttaaaccat tgatcaaagt ctacaccgga gtactttatt gtttcgatgc 2560141 gttcttccgg aatccctctt gctttgattt tttcaagcat gcttttgctg ctgattttgc 2560201 tcatgccgca atcgtgatgc ccgatcacac acacctcatc tgcattcagc tcgtacactg 2560261 cgacgagtat acttctcatg atgcttccga atgggtgtgt cacaagcgca ccggcacttt 2560321 taatgatttt cacatcaccg tttcgcaaat tcatcgcatg cggcagcagt tcaaccagac 2560381 gagtatccat gcaagaaaga atcgccattt ttttatctgg aaattttgat gtttgatact 2560441 tttcatactc tctttgttca gtaaatgtct tgttaaattc gagaatatca tttagaagac 2560501 tcatgttcgt tgtccctttc tattcttttt actcttcaat atatcacaac ccttgtttat 2560561 tcgtcataat aaaaaaagac aaaccctcag gcctgcctta tttccccatg ttatagcgtt 2560621 ttttgaactg ctcaactcgt ccgccttttt cattgaattt ctggcggcct gtataaaacg 2560681 gatgcgtgtc agagcttacc tctactttaa tgacaggata tgtgtttccg tcctcccact 2560741 ctgctgtttc attagatgtt ttcgtagagg tgcttagaaa acggtagccg ctgttgacat 2560801 cctgaaatat cactttgtgg ttctttggat gaattccttc tttcatgggt atctcctttc 2560861 aataaatcgt aataattacg ttttatttta taaccttaca aacgttttgt caatcttctt 2560921 atatccttcc ctctgtttca catcgtaaac ctcatggcat ttaagaatag gaagaataat 2560981 ctaaccgagg aagcaaataa taaacccaaa atacatacag aacgtctttt tggaaaggtg 2561041 gtttacgatt gtggatgatt tagttttggc cagaagcctt tttggcacga cgatgggctt 2561101 tcatatcatt ttcgcaacac ttggagtcgg tctgccgctc atgattttag tggcggaatt 2561161 gatctatcaa aaaacgaaag atgaccatta tgcgatcatg gcgaaaagat ggacgaaagc 2561221 acaagccgtt ttgctggggg tcgccatacc gaccggaacg atcgcgggca ctcagctcgc 2561281 gcttttatgg ccgggattta tggaagtcat cggccgggtg atgtccctgc catttcaaat 2561341 tgaaatctat gctttttttg ttgaagccct attcatgtcg atttatgtat acgctgcaga 2561401 ccgtttgtca cctgcaatga ggattgttgc tgttttcttt gtgttagtcg gggcagcagc 2561461 atccgctgtt ctgatcacga atgttcacgc ttttgaaggt acgcccgccg gttttaaaat 2561521 tttaaacgga aaaattacag atgttgaccc gtgggctgcg ttttttaatc ctagcttttt 2561581 tatcactgcc ggccatgtcg tgctgtccgc gtttatgact ggtgcgttta tcgtggcttc 2561641 tgttgcggcg tataaaatga tccgaacgag gaaaaaggaa agggtctatc gctttcaccg 2561701 gaaagccctt ttgctcgcac tgacgatcgg cggtattttt tcattgctga ccgctttgaa 2561761 cggacacgaa tctgcacaga tgctgtacga ataccagccc gaaaaattag ccggtgcgga 2561821 aggcctattt gaaacaagat cccacgcccc gctcgctatc ggcggtttta ccgacccgaa 2561881 tgaagaaaaa gtaaaatggg caatcgagat tccatgggct ttaagctttt tggcagcgaa 2561941 ccgttttgac actgttgtaa aaggattaaa tgcatttccg agagatgaat ggccgccgct 2562001 tttcattcac acgctgttta atgcgatggt tggtgtaggc atgctgctaa ttctttattc 2562061 cattatcggt gtggtctgga gaaaggtgct caagaaagac cgtttcccaa cgtggctttt 2562121 gatcattttc atgacagcag gcccttttag tctcatcggc attgaattcg gctggatttt 2562181 cgcatgtacg gggaggcagc cttgggtcat ctatcatctg ctgaaaacgt cagatgtcgt 2562241 aacaacgact ggctcgatcg gggtgctgtt cttatttttc acatttgttt atgccgtgtt 2562301 aggcgcagct gtcgtctacg tgctgctgta ttatttccgc aagcacccgg ttgacgaaga 2562361 tttaaataca gcggagtcgt aatggctccg caaacaggaa accaaatgga aggaagatcg 2562421 tacaaatgga gatttcaact gacgctctga tcgccatctc aattatctgg ggctttgtgt 2562481 ttatttacgc cgtcatggcg acaatggatt ttggagcggg attttggtct atgatctatt 2562541 taaacaagga gcatatgaag gccaccgata ttgcgaatcg ctttttgtcc ccgacttggg 2562601 aggtcacaaa cgtctttatt gtggccatcg tcgtggcgct tttcagtttt ttccccggcg 2562661 cgacatttgt gctcggcacc gttttattaa ttcccggaag catgattttg ctgcttttag 2562721 caattcgaag cggatttctc gtgttttcaa atacagcaaa ggagcggaaa acgctaagat 2562781 atatttccgg catctccggc tttatcattc ctgctatttt aattttggtg cttcctgtga 2562841 cacacggagg gtttatagaa aaaacggatg gaatctataa cttaaatatg tctaaaatct 2562901 tttcaagccc caacgcctat tcatttatcg ggtttgcgat tttaagcacc ttatttttgt 2562961 cctcgctgtt gcttgcagat ttttcaaatg tggcagagga acaggatgcg taccgagcct 2563021 acagaaaaag cgccctgatt accggcccga tttcactgtt gtttgctgta tgcattatgg 2563081 taactatgcg gaatgaagca aactggctgt acagcggaat gatgaatgat ttttcttgga 2563141 ttattgcatc gttcattaca tttgtcattg ctggaatcgc tctttttctg cctaacaaaa 2563201 gctttggtca aaacatcgga aaaccgcgtc tcgcacttgt tgcgattggg atacagtatt 2563261 ttctcgcaag ctacgcgtac gggcgggcgc atcttccgta tatgatttat cccgatgtga 2563321 cagtcatgtc aggcttcaca gagccagcaa cgttcagagc gctgtttgca acgtatatcg 2563381 ttgcatttat cattctattt ccgggcttct ttttcttctg gaaaatgttt atgcgagata 2563441 aacgctatat ccgccaggag gaatagaggg caagccagcc ggctatacta atccagaacc 2563501 tttataagga ggggatggca tggagcagaa aattctatgt gaggtcaaca actgttctta 2563561 ttggggcaaa ggtaacaaat gcaccgctga tgccatttat gttgtcagcc atactggtga 2563621 aacggctgaa aacagccggg aaacagactg caaaacgttt aagccgcatg atttataatt 2563681 aaaagaaaga gctgcatcag ccagctcttt ctttttgcat gttgagtgtt ctcagctttt 2563741 tagttatgac cccgtttgca ggtgaaaaca aaaaggcgct tgcataacat acacctgtca 2563801 tggccgccat cgctcctgaa atcgaaacat taagccacgt tgcgaagaaa tagcccatga 2563861 ccgccgacag cccgccaatc aacgcgctga gaatcagcat ataaagaagc cggtctgtca 2563921 gcaaatgtgc cgcagccggc ggaacaatca gcatggccac aaccaatacg gcacccaccg 2563981 aatcaaagga agcaacagtc gtcaaggaca gcatgcccat ttgcacgtaa tgaatgagca 2564041 aaaccggtat tcccaaggct aaagccattt gaggatcaaa cgaagcgatt ttaaactcct 2564101 tatagcacac actgatcaac actacgttta aaaccagaac agatgccagc atccaaaacg 2564161 ctttcggccc aatatcaacc ccgaataccg tcaccgtatt ccacggcaca aaagcgattt 2564221 ctcccattaa cgagtgctca atatcgagat ggacattcgc tccatacaca gaaagcaaaa 2564281 taaccccgat tgcaaataag gatgtaaaca caactcctat ggcagcatct gattgaaccc 2564341 ccttgctatg aagaagctga accaagaaag ccgttaacag accggttgcg gctgcgccaa 2564401 taaacatata aatcccatcg agacttcccg tcactagaaa agcgccgaca atgccaagca 2564461 acactgtgtg actgattgcg tcggccagca tcgccatgct tctcagcaca agaaatgtgc 2564521 cgatcaatcc gcagcttaca ccgactaata caccggtagc tataatccat gcttcaaaac 2564581 tcatttgcga tctgtccctt ctcggcatca tgagacgctt ttcgacgctc aggcatccgt 2564641 ccatacagct ttaagagtga ataaagccgc tctctcgttt ctctcggtaa acggtccggg 2564701 tcaaagtagt cctgatcgga ttctatattg gcaagttcca tttcatgcat gagatacact 2564761 tcatacatcc gctgcttcaa agctgtgtga tagccttttt ctatcccttt gcttgtgatt 2564821 tgccaaatcc cattttcgat acgctcaatg cacctctctt gttccaagtc atttaatgcc 2564881 ttaaggcata atgaagggga taggcgtctt ttctttctta cactttcaac agttacacaa 2564941 agattattct tttcatactg ttcataaatc gccaaaagca cttgctccct gcttgttctg 2565001 cgccgcagcc tcatcagcct tatggcttta gcagccaatc cccgcttagg cgcgcaaatc 2565061 attgaaaaaa gaaagagcag cgttgcagat aagatcatta atggccctgt cgccattccc 2565121 ttcatcgtgg tgctaagcag ggttccggcc actccgctga ccccgcctgt aatcccggca 2565181 atgatgatca tcccggttaa tcgttcggtc caatatctcg cggttatggc aggtgtaatc 2565241 agcatagccg ccattaatat cacaccaaca gtctgaagcc caatgacgac agcacagaca 2565301 atcagacaag ccaaaagccc gtttaaaaaa cgcaccggga ttcctaatcc ctttgcaaac 2565361 gcgagatcaa aagtaatcaa tgtaaattcc ttaaagaaaa caatacatag gagcagtaga 2565421 acagcggata tccctgcaat aaggatgata tcctgcctga ccaatgaagc agcctggccg 2565481 aataaaaaag aatcaagccc gctttggctt cccgccccct gttgctgaat atatgtcagc 2565541 agaatgatcc cgacgccaaa aaacacagaa agaacaatcc cgatcgccga gtcctccttt 2565601 gtttttgaaa gccgaggaat cagctgaata caaaacgttc cgagcagtcc ggcgagcgct 2565661 gcccccagca aaaagaaagg cagtgatttt tgcccggtga acagaaaagc gagacacact 2565721 cccggcagag ctgaatgggc catcgcatcg ccgattaaac tttgctttct cagcagcaca 2565781 aagctgccca aaacaccgct tgccgtcccg agcaaaagcg taccggccag cacccactgt 2565841 gtattcggat gctgaagctg cagccacaaa ctttcaaaca ttgcgctcac tccttatgtc 2565901 cttctgccag cactttatct tttaaaaacg taagccttcc tccatatgtt ttttgcaggt 2565961 tttcgatcgt aaaaacgttt tccgtcggtc cgaaagcgat tttccttaaa tgaagcagta 2566021 agatccaatc gaaataatcc tcggcggtct gcagatcatg atggacgaca agcacggttt 2566081 ttcctttttc tttgagttct gccaacagcg tcataatcgc gcgctccgtc gctgcatcaa 2566141 cacctgcaaa cggttcatcc ataaaataaa tgtcagcgtt ctggcagagt gcccgggcaa 2566201 gaaacacccg ctgctgctgt ccgcctgaca gctggctgat ttgccttttc gcataatcat 2566261 gcatcccgac ttttgttaat gcggccttcg ccatctccac atccgctttc tttggcctct 2566321 ttaataaacc gattctcccg tatcttccca ttaggacgac atcgagcggg cttgtgggga 2566381 aatcccagtc aaccgagccg cgctgcggaa catatccgat tctggtccgc tgatccttat 2566441 agtctttgcc gtaaatagag atgtctccgg aagctctggg cacaagaccg agaatcgttt 2566501 tgatcaaggt tgattttccc gcgccgtttg ggccgataat gccaataagt tttccttcag 2566561 gcacctgcag cgaaatgtcc tgcagtacag gctttttatg ataagcaacc gtcacattat 2566621 caagctcaac agggaacata tcctccacct cttttcttta tttaagcgct ttagtaatcg 2566681 tgttgatatt gtggcggaac attccttcgt atgtgccttc ttttgtgccc ttttcaccca 2566741 tggcatccga ataaagctga ccgccgattg tgactgtatg gcctttttct ttagcgcctt 2566801 ccaccactgc attgattgat ttttcagata cactgctttc tacgaacaca gcttttattt 2566861 gtttttctgt cagaagatca accagctcct gaacatccct taatccatag tccgaatctg 2566921 tgctgagtcc ctgcaggcct tttaccttaa atccatactc attcccaaag tacgcaaacg 2566981 catcatgagc agtcacaagc acacggcttt tctccggaat atgtgcgatc tccttacgcg 2567041 accacttatc taaatattgc aaatcttctt tgtactcttt ggcatttttc cgaaaggcat 2567101 ctgcgtgctg aggcattgct ttgctgaatt gcgcttcaat ttcatccacc gcatagatcc 2567161 ataacggaat gctgaaccag acgtggggat caaacgtctt gccttccccc gcgggaataa 2567221 gcttattttt cggaatggcc tcagctactg ccgccgattg tttttgttcg ccgatttttt 2567281 ggaggacatc ctccattttc ccttccaaat gcaacccgct gtacagaaca acatcggcag 2567341 acattaattt tttcgtgtca ccttgggaag ctttgtaaag gtgcggatca acccccggtc 2567401 ccattaaaga ggtgactttt acgtgcttac ctccgatgtt ttctgctgca tcggcaattt 2567461 gagatgttgt cgctgtcact tgtaattgct gatcagcgct ttttccggct gaatccgttc 2567521 cgcatcccgt taaagcaaag gtcgcaaaaa gtactgctgc catcagccct tgtctcatat 2567581 ttctcctcct ctttgccatc aatgtccgat tgttttatct tatgttgtca gttcttagac 2567641 atgtgacatt aaattagcca aaagcatgtt ttatttacac aggacaaaaa gtttccctca 2567701 tgcaaaatta tcgcgtttgg ccatttttgt caagctgatt tacataaaaa aaccggctgg 2567761 gtcagcagcc ggtccaaacg agaagggatg tattcaacga acacttttac tgtaacagca 2567821 cagtgtcatt tattcaaaat agcaaaatgc ttttttctta accatgctgt gtgaaaacat 2567881 ccattttggt cacatatttt cgcataatat cttggtttac ctcaacccct aaaccaggct 2567941 gttttgacac agaaataaat ccattatcaa tacgaatatc aggagttaca atatcttcat 2568001 cccaatagcg tgaggatgaa gatatatcgc caggtattgt gaattgaggc agtgaagcaa 2568061 gcgccacgtt ctgcgctctt gatatgcctg tttccagcat tcctccgcac caaacctgca 2568121 tatgatgctc tttgcataaa tcatgaattt ttaaggcttc tgttaagccg ccgacacgag 2568181 aaggttttat attaataatt ttgcagcttc ctagctcaat cgcccgtctc gcatcatcaa 2568241 ctgaacaaat gctctcatca aggcaaatgg ccgttttcaa atgtttctgc aagtggcggt 2568301 ggtcaacgat atcgtcagct tggagcggct gctcaatcat cattaaatga tagtcatcaa 2568361 gctcctttaa acggctgata tccttcagtt cgtaagagga attggcatcg gccataagcg 2568421 ggatggttgg gaatcggctg cggatggcct tgaccaattc cacatcctgc ccaggctgaa 2568481 ttttaatttt tattctttga taaccttctt tttgatagct ctcaatttcc ttcagcatat 2568541 cgtcaagagg cgccaggccg actaccaccc cggcagggac tttatctctt gttccgccca 2568601 atgcctcagc aagggatacg cccttctttt tggcataaat atcccataca gccgattcaa 2568661 gtcccgcttt tgccatccgg tttcctttat accgcgccag gctgtccggc acttctgaag 2568721 ggtgattgaa ttcacggccg acgacatttg ggataaaaaa atcttttagc atatgcaaac 2568781 atgttccaat ggtttcctcg gtgtaccaag gcgaagagaa agcggaaact tctccccagc 2568841 ctgtgacacc tgatgtatca atggcttcca cgatcagaaa tttacgctct tgaagcgttt 2568901 cgatactgtt tttaaacggt ttctttaagt tcatgctcaa atggtaaagc gtgatttttt 2568961 ctatttcgat catagcagtt ctcctttacg cgcatccttc agctgatttc gcaagagctt 2569021 attagacgca ttgcgcggca ggcggtcaag cacaaagaat tttgccggaa ttttatactt 2569081 cgccaagcgt tctttgcagt agtcagtcaa ttctcctgcg ctcacaggct tgtgaaggac 2569141 aagataggcg tgaggcactt tcccccattt tttgtcctca gcccctgaaa ccccggcttc 2569201 ggccacagcg gggtgtgaaa gcagcactga ctccacttcg gccggataaa tgttttctcc 2569261 gccggatatg atcagatctg aacgtctgtc taatacatat aaaaagcctt cattgtccaa 2569321 ataaccaaga tcacctgttt tcagccagcc attttgaaag gaggcttcgt ttgcgctctc 2569381 ccggttaaaa tagcttttca tgacattcgg gcctttgacc atgatttcac cgtgttcata 2569441 cggttcacat acctgtccgt cccgctctat tttgatttca cacgaaaaca gcggtttccc 2569501 cgcagatccg agcttttcca tgctgaattc cggcgacagg gtaacaattt gcgagcatgt 2569561 ttctgtcatt ccatatgact gaaagacagg gaatcctttc tcacggcatt cctcaagcaa 2569621 tggcagcggt gcaggaccgc cgccgagaag aatgcatctg atggattcag ggcagcggtt 2569681 tgtttcttcc aaaagactgg ccagcatagt ctgcaccgca gatatcattg tcacttcatg 2569741 cctgttgata gaatgcagca catcgcttac ggaaaaacgc tggtgaagca cgacagtcat 2569801 tccatagatc acagatttaa ataatgcgga caatccgctg atatgaaaga gcggcaatgc 2569861 gataagccag cggtcttgtt ctgttatacc caaattaaga gcggacgaca ccgcactgaa 2569921 ataatggttt ccgaacgttt gctgaactcc cttgggcttt cctgtcgtac ccgacgtata 2569981 catcagcgtt gccgttgcat ccatttgcat ataagcctcg atctcaattt cctctgctgc 2570041 ttctttcatc agttcatcca catcaatcgt ttgaacgatg tgttcatatt ctttcttctc 2570101 aaagcttgaa tctgtcaata aaaagccgga tcccgaatcc tccagctgaa acagcctttc 2570161 atgtgttgac agcttcgtat tcaaaagcac cgccttaaca ccaagcaaaa aacaagcgtg 2570221 aacagcgtat accatttctg cacggttttg gagcaaaata gctgcagtat cccctttccg 2570281 aaccgaatga gcggcaagct gttccgccat tcgtttagac gcggcaaaca attctgcaaa 2570341 tgtcacggtt tggtcttcat agatgagagc gattctctca ggtgtcagct gtgcccgctg 2570401 catgagccag ttgggctgtt ctgtcagcat gtcatcatct ccgaggtaaa atgtctgtat 2570461 tgaaaagaaa acagcttgga ccgcaaagtc tcaagctgtt ggtttactag atattgctga 2570521 tcacggaaaa cgagggaact gtccgaaatc aggtttgcgt ttttccttaa aggaatcacg 2570581 gccttctttt gcttcatctg ttgtgtagta aagaagggta gcatcccctg caaactgctg 2570641 aattccagca agtccgtctg tgtccgcgtt aaacgcagct ttaagaaagc gcagtgcggt 2570701 cgggcttttt tcaagcattt cttcacacca tttaatcgtt tcttcttcaa gctgttccaa 2570761 aggaacgact gtgttgacaa gacccatgtc cagtgcttcc tgtgcgttgt actgacggca 2570821 taggtaccag atttcacgtg cttttttatg tcctacaatt cgagccaggt agccagaacc 2570881 gtaacctgca tcgaagcttc ccactttagg gcctgtttgt ccaaaaattg cgttgtccgc 2570941 agcaattgtc aagtcacata cgatgtgaag cacatggcct ccgccgatcg catatccgga 2571001 caccatcgca acaaccggtt tcgggatgac gcggattaaa cgctgaagat ccaatacgtt 2571061 aagacgaggg atctggtcgt ctcctacata tccaccgtgg ccgcgcactt tttggtctcc 2571121 gccagaacaa aatgctttgt cccctgcacc ggcaagcacg ataaccccaa cgttttggtc 2571181 gtctcttgcg tcagcaaacg catcaatcat ttcagcaacc gttttagggg taaacgcatt 2571241 atgtacctca ggtcggttga ttgttatttt tgcaatgcca ttatacgttt catacaatat 2571301 ctcatcgtat gtccgttttg ttttccattc agccatatga tgacctcctt ttattctcta 2571361 tgtgaatgag tcagatgctt gtcaaaaact cactcactat tttaccaaac aatcgcggct 2571421 gctccacatg gaccgtatgt cctgcttttg gaacaatctc tattctacta gaaggaagca 2571481 tcttatgcac ctcttgattg atggcgcaaa atttttcgtc ccactccccg cagatcagaa 2571541 gcacaggaac atctatttcc tctacacggc tccacaagga aggctgtgaa ccggtgccca 2571601 tgccggttaa actgttcgca agcccaatct tattgttccg cagacggccc gatcgtatcc 2571661 tgtaccgaat atcttcagcc agcctctgct gagatgaaaa caaagggata ttctcccaat 2571721 acgcaacaaa cgcttcgagc ccgtctcgta aaataaaatc agcaagcttc cggtcccgca 2571781 tgattcgttc ccgccgttcc ccaagtgttt tgagccccgg cgtcgtgctt tcaagcacaa 2571841 gtgccgatac ccgctcggga tatgtcatcg caaaagagta agcaagcctt cctcccatag 2571901 aatacccaat caatttcact ttgtgaagtt ttaattgatc aaaaatctcg gcaaggtcag 2571961 aaacttgccg ggttgtgctg tatcttttcc cattcagcgg ggcatcggtt tccccatgcc 2572021 ctaaacaatc aattttgatc aaacgggaat caggcagcat ttcatcaaga aaagtccatg 2572081 attgtttgct gccggtaaac ccatgcagac agacgacggc ttcggaagca ttcggtccct 2572141 cgtctgccac tgcatatcgg acaccatctg ataccgttat gtttacagtt cccattgttt 2572201 tttcacttcc cgcacagcct cattcagcat atcgcgatga agctggactc ttgattggcg 2572261 atccgttttg atttcaatca aatggagtcc gggcttgtct gcctgcggcg cgtaagctgt 2572321 tttgaattca tcccaagaag ccgggcatga atacgttccg ccgtaaagtg cagccgcatg 2572381 cttgaaatcg agccctgtcg gtgtgccgaa caaatcttca aagtgtgtct tctcagaagc 2572441 ctgcggcaaa aaggagaaaa tccctcctcc gtcattattg acaagaatca cagtaagagg 2572501 aatacccagc tttttggccg ccagcaggcc gtttaaatca tgataaaaag ataaatctcc 2572561 aatcacaagg gtaacaggcg cttttgttcc ttcacatacc cccatggcag aggagacgac 2572621 accgtctatc ccgtttgctc cccggtttga ataaatccgg aaagggcggt cctgcttttc 2572681 aaaaaacgta tcaacatccc tgatcggcat gctgtttccc acaaacagcg agctgttttc 2572741 aggcacaaga tgctgaagga ttcgatagag attgccttca aacgaaacat cttcactgct 2572801 gattgtttgc agatgctcgc ggaaccgccc attgacaaac tgccactttt ccagccactc 2572861 tgaggatctg gtggcagcag taaggcctgc catgatctcc tcagcaaaaa cagacgcatt 2572921 acaatgaatc atatgcgcgc ttgcctgtgt cgggtctctc caccctccat cctcgtcaat 2572981 cacgatttgc tgaatcgtcg gatcatcctt aagccataag aaaaccggtt ttgaaacagg 2573041 catcggtcca aaccgaatga caacatcagg acggagtttc cgcttcagct catcatcttt 2573101 taaaaacgaa tcatacgcat caataacagt gcttttatca tgaacaccat tccgcagatt 2573161 agacagcgga tctgctaaaa ttggatactg aagcgctttt gacagcgcaa taatgttttc 2573221 cttgtccgca tcactatgga gctctccgca gacgatcatt cctttttcag cctctgcgag 2573281 catctcagcc acatcagaca gggactctcg gtcaacagac tgcgtacccg ttttcacaga 2573341 cacatgacgg cctgttctca ttcttccaaa cggctcatct gaaagatccg gcatcagcgg 2573401 ttcgcgcagc ggcacattca catggacagg ccccatcggg cgcttttgtg cttctccggc 2573461 agcgcggctt gccagcgttc ggatgtatct cagcatttgc ggagactctt caggaagagc 2573521 agagtctgtg aaaaacttaa caaagttacc gaataagaag tgctgattaa tagcctgcgg 2573581 tgcgcctact tcgcgcagct catgaggccg atcagcagtt aacacaataa taggcaccct 2573641 tgaataatgg gcttcaacca cagccggata aaagttggcc gcggctgttc cagatgtaca 2573701 gatcaatagt acgggacgct gcttcgcttt tgccaaacct aatgcaaaaa atccggcaga 2573761 cctttcatca atttggacat ggacgctgat atcgggatgc gcagcacaaa gaacagccag 2573821 cggtgtagat cttgagcccg gacaaacgac ggcgtccgta attccggaaa gggcgaattc 2573881 atcaataaaa cttccgatgt aatgagtaat cgggttgact gtcaacgcct ctcacctcct 2573941 aatgcagaga tcatcggctt caatttaatc tgtgtttctt catattccga gattggttcc 2574001 gagtcttcca caataccgca cccggcaaac agccttgctg tgcttccttc gatgagccct 2574061 gaacgaatgg cgaccgcgaa ttccccgtta tcctggctgt caatccagcc gataggggcc 2574121 gcataccagc cgcgggacat cggttcaatc tccctgatca cgtcaacagc tttttcctga 2574181 ggtgatcccc caagcgcggg agtggggtgc agcttctcaa ttaagtcaaa aatcgaagca 2574241 gactcgcgca gctgtccgac aatcggcgta aacaggtgct gaacgctttt tgttttgtac 2574301 aaaacaggtc catcaggctt ttcaacctct gaacagcttg atacaaaagc attatgaatc 2574361 atacctacca caatatcatg ctcaagcagg tttttctcat cgtttaataa ttcaaggcct 2574421 atccggcggt cgtcttcttc attcacgcct cgtttaatgg agcctgccag acaggaagac 2574481 atgacagtgc cgccgtctct tttgatcagt ctttccggag acgcgccgac aaaggttttg 2574541 ccttcttgtt caattgcaaa aacatagctt gtctgctgat cgtccagaag cgttttaagc 2574601 accggttcaa tttggattgg accgtcaaac gtgagcagca gctctcgggc aagaacaacc 2574661 ttatcatatt gtttctcttt aatttggctt gtggccgttt cgattgcttt cagccaatca 2574721 tccttatcca gctcttcggc tgctgcaatc acagcctgat cttcttgctt gaaatcggga 2574781 accataaatt ccgccgcaaa agcttttaag ccttctaaaa cagcttctgc gtcttctcct 2574841 ccgcttaccc atctgttaac tgttaagaac gggccttcag cagtcatcgt cagcataagc 2574901 gcaggcacaa agaaatcccc ttccgagaaa tggtcccatt gtgaacctct ttcttcgcaa 2574961 gggtcaaaag aaaatcctcc gaataacaca ggtcccactg cagaatgctg cagcttttct 2575021 tcttcataaa tatgaaaagc cgtcttttta aagcgctccc attgttcaaa aacctcacga 2575081 taccgctcgc tgtttttttg atttgtctgg aaaaccgctt ctttgccaag accgactatt 2575141 gtcaattcac tttcaggatc tgaccaaaaa aatcgattgc ctgtatattt ttttgctccg 2575201 taattgaaaa atgatagagg gtcaagagac tcgatttgtc tcgaatagct tattaagaca 2575261 gcatggttga cttctttggc tttatgtaat gcatgtagaa cttcctttcg gaacgtacgc 2575321 tgcaccgttg tcaccatgag acattcctcc ataatcctta aaatgctttt aataccatac 2575381 acctgtgtct cctttgtgtc aaacacagat catgcagtcc aaatggcctg ccttacctat 2575441 tataaaccta atttcagaaa tgaaaaagaa acaaagctta aatttctttc tccactgata 2575501 gcaaaggttg tatccgctta ccataaaagg aaaacctcct atattcctcc acccgccatt 2575561 tatgaaagtt ctcaggcgat ctgttcatac taaaggtatg catcacagag aaacgaggcg 2575621 atcacattgc ttacgaaaga acagcttcag catttaaaaa atgaactgga acaaacgaaa 2575681 aaagatatct taaaccgttt caaagacaat gatcattttc agcttaactc agcctttcct 2575741 tatgattcgt ggggtgagct ttcggcatac gacaaccatc ccggcgatca ggcgacagaa 2575801 ctttacgagc gtgagaaaga catcgctcta gacttgcatg agagagagca ccttcgggac 2575861 attgagcatt cattgaaggc gatagaaaac ggtacgtatg gcatttgtga agtcagcgga 2575921 aaggaaatcc ctttcgaacg acttgaagcg cttccgactg ccacaaccct cgcggagtat 2575981 tcgtcacagg acgtggtttc caaagaccgt ccgattgaag aagaaacacc attcgggcaa 2576041 tttgaatttg atgatgatga agaaatcaga gcgccatatg acagtgagga ttcctatcag 2576101 gatgtcgaaa aatatgggaa ctcacaaacg ccgcaggata tggaaaaccc tccgctcagc 2576161 tatgatgata tgacgatgaa tgccgaagag aatatcggca atacggagtc ttacgaaaat 2576221 ttcatcgcta cagatatcac tgggaaagaa attaccgttt atcaaagcag agcccatgag 2576281 cgctatgaag aagaacttga cgaagaggga atcatgacca cattcggcga tctccacgct 2576341 gattgaaccc ccaattattg ggggttcttt tccgttttca gcatatcgta aatcagcttc 2576401 agataatcct tttgcaggcc gatgtcatac cgctcgccct ctagcaattt cccgtatacg 2576461 gtacatgccc cgagcgaagc ttttatcgca tccgttacct gcacttctcc tccgctatca 2576521 gcttctaatg cctccagctc attaaaaata tccggtgtga aaatataacg ccctgctgcg 2576581 gcaaaatgag acggagggtt ttgtttaggc ttttccacaa tatcctgtat gcgataaagc 2576641 cctttttcaa caggctcccc ttttatcacc ccgtaatgat gtaaatcctc cgtttttgtt 2576701 tcttttaagc cgatcacact ggactgatat ttcgtatacg cttcaatcag ctgccccaaa 2576761 gccggctgat tggcggaaaa aatcagatca tctggcaaaa cgacggcaaa aggctctcct 2576821 cctgcaaatt gctttccgaa agaaatggcg tcgccaagac cctttgcata aggctgccgc 2576881 acatagtgaa tccgtatatc cggaatggga tgctctctaa gtaaatgcag tttattctta 2576941 gaggccaaaa aagcctcaag tgccaaagag gaatcaaaat agtcgacaat cagattttta 2577001 tggctcgata caaccatcaa aatgtcctca atgcctgact cctttaattc ttcaacaaga 2577061 taatgaatca caggcttaga tcctaccgga aacatttctt tcggaatcac cttcgtcacc 2577121 ggcagatttc tcgtgccgaa tccgcctgca ggaatgatcg ctttttttat catggtattt 2577181 tcccctcagc tcatgtttat tacatgatat tccaagagcg catcccgatg tttgtacatc 2577241 tgaaattagg cggaagcaac tgggcagaaa gcggaatcac gaaccagccc ttttttaata 2577301 ggatattgat atatgaccag taatcttgta aaggagctca ggtgatgaaa atttgtgtgg 2577361 ttggcgccgg gtatgtcggt ttaaccctat cagcggcact ggcatccatc ggacatgaca 2577421 tgatatgcac agacaaagac gtcaaaaaaa tcgggcagct gaaaaaagga gtcattccct 2577481 tttacgagcc tgggctttca gatgcaatac ttcgttgcgg caatctctcg ttttcttctg 2577541 aagtgaaatc gagcatggag gaatgtcccg ttatttttat cgcagtcgga actccgccgc 2577601 gttcggacgg atcagctgat acgaaagccc tgcagtccgt catcggtgat ttaagcgagg 2577661 cgatccgatc gtataaaacc attattacga aaagcactgt tccgcccggg acaaatgaaa 2577721 acatagcaaa acagctgatt gcctccggag tgtctaaaaa cctctttaat atcgtatcca 2577781 atccggagtt tctgcgggaa ggcaatgcct tatatgacat gctgcatcct gacaaaacag 2577841 tcatcggtgt tcaggaagaa gatcacgtat cggcagccat cgtcaaatcc atttacaaac 2577901 acattgatac cccttttatc gttacaagct tagcgggagc agagctgatc aaatatgcca 2577961 acaatttctt tttagcggcc aaaatttcgt tcattaacga aatggcccgc atatgtgaag 2578021 cctatcaatc agatatctca gatatttccc gcgctatcgg tctagaccca aggatcggga 2578081 agcacttttt gcaggcaggc atcggatacg gaggctcttg ttttccaaag gatctgcagg 2578141 cgctgcaatt tgctgcccag gaaaaaaaca cggagacctt cctgctccgg gccgtgcagc 2578201 acattaatga cacccagctt ggcctgtata tcaaaaaaat acagtcattc ttcgaaacac 2578261 ttcaaggcaa gaaagcggct gtactcggca tttccttcaa accgaatact gatgacatcc 2578321 ggaattctca ggctgtcaga ctgatggaaa ggctggcgga gctgggatgt gatgttcatg 2578381 catatgatcc tgaagctgta cttccagaac atttgcggca acatgtaact cagcattctc 2578441 aagcttttga tgcgatcgaa gagagtgact ttttattttt ggcgacagaa tggtctgagt 2578501 ttttagcgtt tgattggaaa aaggctgcag atatcatgaa agggcgtctt gtgattgacg 2578561 gacgcaacgt actaaaaaaa gaactgatcg aggcttgcgg cctgatctgt acgggagttg 2578621 gccgtccatg aaaatactcg tcacaggagc agcgggcttt atcggctccc acctctgcga 2578681 agaattacta aaagataaga aacataacgt tatcggaatc gatgacttta tcggtcctac 2578741 tccattttcc ttgaaattaa aaaaccttaa aaacctgctg ccggaaaagc gatttacgtt 2578801 cataaaggaa aatctgctga cagccgatct tgcttcctta ctggaaggag tggacgtcat 2578861 ctttcatttg gcggccatac cgggtgtccg ctcaagctgg ggcaatcatt ttcacccata 2578921 tgccgcacat aatatccaag cgctccaaag gctcctcgag gcgtgccggg aacattctat 2578981 tcaaacgttc gtctttgcat ccacctcttc cgtctatggc gaaaaacaag gaaaagtcag 2579041 cgaaaacacg tcgctttctc ctttatctcc gtacggggta acaaagctta cgggagaaaa 2579101 gctttgccat gtgtataaac agagctttgg cattccaatt gtgattctcc gtttttttac 2579161 cgtatacggg ccaagacagc ggccggatat ggcttttcac cggctcatta agcagcacct 2579221 tcagcaaaag ccgcttacca tcttcggtga tgggcagcag tcaagagatt tcacttatat 2579281 cagcgactgt gtcaaaggca tcaccgctgt tcttgggaaa ccccacctta ttggtgaaac 2579341 agtaaatatc ggcggcgcag agcgtgcctc agtcttaaaa gttgtctccc tcattgagga 2579401 tatttccggg agaaaagcaa cactgcactt ttcggacaaa atagcagggg aaccgagcaa 2579461 cacgtgggcg gatatttcaa aagcaaaaca gctcttgcat tatgatcccg ccacatcctt 2579521 aaaggatggc ttgaccaacg aaatcgccta tttatcgtcg ctgtatcagg gggaataaaa 2579581 atgaagcttg cctttatctg tacagaaaag ctgccggcgc ccgcagtacg cggcggcgct 2579641 attcaaatga tgattgacgg tgtcacgccc tatttcagca gcaggtacga cctgaccatt 2579701 ttttcaatag aagatccatc gctcccaaaa agagaaacaa aagacggcgt acattatatc 2579761 catctgccaa aagaacatta ccgcgaggcg gtagccgaag agctgcgagc ctcttccttt 2579821 gacctcattc atgtgttcaa caggccttta aatgtctctt tatataaaaa agcctcacca 2579881 aacagcaaga tcgttctgag cctgcataac gaaatgtttt ctgaaaaaaa gatgaccttc 2579941 gcgcaaggaa aagaagtact cgacaatgtc tccatgatca caacagtgag cgaatttatt 2580001 aaacaaaccg tcattgaacg tttccctgaa gccgaggaca tcacaaaagt tgtgtattcc 2580061 ggcgttgatt taaactctta tccgcccgtc tggacgatga aaggctcggc tgtcagaaaa 2580121 acataccgga aaaaatacgg tattgaagat aaaaaagtta ttttattcgc cggccgctta 2580181 agcccgacaa aagggcctca ccttctcatt cacagcatga gacggatttt gcagcagcac 2580241 cctgatgctg tactggtcat agcaggcggg aagtggttca gcgatgacag cgaaaaccaa 2580301 tatgtcacct atctgcgcac gctggcgctg ccatacagag accacataat ctttacaaaa 2580361 ttcattcccg cagacgatat cccaaacctt tttctgatgg cagatgtatt tgtgtgcagc 2580421 tctcagtgga acgaacccct cgcccgtgtg aattatgaag caatggcggc cggcacgccc 2580481 ttaattacca caaaccgggg cggaaacggt gaagtcgtaa aacacgaagt caccggcctt 2580541 gtcatcgata gctacaacaa accttcttca tttgcaaaag caattgacag agcctttaca 2580601 gatcaagaat taatgaacaa aatgacaaaa aacgcccgaa agcatgtaga agctttattt 2580661 acctttaccc atgctgccaa aaggctcaat actgtttacc aatccgttct gaccccgaaa 2580721 aacaaacaat ttccgccgcc ttttctgacg caaaattttg atttatcatc tatcaatcag 2580781 ctttttgtga aagcaaaaac ataaaaccta cagctcgtgt tgcaaaacgg gctgtttttt 2580841 cgctacagag aacttaaaaa aaggcataaa tgtgacttta tgccttgcgc tttacagttt 2580901 gagaaaacca tggagctggt ttagattcac ttggaagaat gatgatttcc actttagctt 2580961 cttccgctaa gtctggttct tcatcttcat cctcttcttc atatgggggc gctgagcgtt 2581021 tcgaatcacg ctcctcctca ggctccagag tggtttcgaa ttttgtttct tcttcatcat 2581081 cgacgatttt gcgatctgtt tccttttcct tcgtttcttt ttgatattct ttcggtgcat 2581141 tgatgtgagg gagctctcga atgctgccca catctaaatg cttctcctct tcttccttct 2581201 cagctgagat tgagtcatga gcctgccatc ccatcggtcc aggcggtgta aatacgaatt 2581261 ggtcgagatc cagtttagaa atagaggctt tttgtctcga tgacctcatg tcaattcgcc 2581321 tcccgatacg cttttatctt tttatacagt tccggcagtt tatccaaaaa cgaatcttta 2581381 gattcttcaa cagaaatcat gttttgcagc gcccagttat acttctcatc tgaccacgtt 2581441 ttcttttgct tcaaataata tttgtgcccg attgcacaga acaaatgcgg aaacgcgaga 2581501 tcaatccaaa gtacctcgta ctgtttttct gtgagcggat acactgcgtc gtaggccgca 2581561 agcagtgcaa ccatgaaatc agtatcccat acagaaagct taaccatcac tttattcagc 2581621 agaatacgaa ggtctcttga cggcaaatcg taggtaatcg agtgaagctc ctttaaaaaa 2581681 ggctcccctt cgatctcagt caaacgtgcc aatgtaaaat cctgaaaaca gaatccgcca 2581741 tgctcgagtg tctcttttgt ccaggtttcg tattctgagt catcaagcgc tctgagagct 2581801 tcttttcctc ttgccagcat tttatcagca tgttttaaga aagtttgcga aaatacgtca 2581861 tcaggatagg atgctgcgat ctgcatattc ccttcaagtt cctgcagctt ccaacggtac 2581921 aatttgtgcc attttcccag cctgcttctc ttcttgcttt catctgtgca aacatatcct 2581981 tttgaggcat gatgaaaatg gccggcaaat gacatgactt ttttcatttg ctctgcatca 2582041 tagtaaatca tttcttttcc tgtcactttg tcatataaac tgtaagaaac ctgatccgtg 2582101 cccaagcagc taccgccatt ttttgtttga tgaatcggcg ctatcggcag ccctttctct 2582161 tgtaaatggg cgtgtgcctg agtgataaaa agcatccgct ccggtttcat ttgcgcttct 2582221 tttagcagct ttgggccatg atcagtttcg acttcccaga ttttgcgccc gcttttgttc 2582281 gatttcagcg ccacatggtc gatatgaaac ggataataac tgagaatttc ggacacaatc 2582341 tgttcttcat gctctttttg gtacactctg ttcacccctt ctatctgttc ttttcataga 2582401 cgctgagcag attttcagcc accctctgcc agccaaaatt gctttctgcc tcacggcggc 2582461 tgtatttccc aagccgttcc cgcttttccg agctgctcag caaatcattg atacgttcgg 2582521 catattgttt aggattttca aagtcatgaa tgatgtagcc gtttttccct tcctctatga 2582581 cctctggatt gcctccccga ttgcttgtaa taataggaag tcccgcagcc atcgcttcat 2582641 aatgcaccct tgctaaaggc tcctgccatt gcgaagagca tacaaataca tctgacatgg 2582701 tataaaggcg cggaatgtcc tttggcttca caaattgaat aaatgtgaca tgatcctttt 2582761 gcatcgcacc aagggtatga agatgtttga catagttatt taattcatta tctccgaacc 2582821 attttgaccc gataaacacc atcatgacat cggggtgctc ctcaatgatg tccggcaaag 2582881 cctgcaataa tatgtgcggg cctttgactt tgctaagccg gccgacaaac aagacgattt 2582941 ttttgccgtg aagccccagc tcgcttcgca tctcttcgcg agctcgctgc ccttcattcg 2583001 tccagcgagg gtggtacgtt tttaaatcca caccagaata caccgttttt gtttttgatc 2583061 gtgctgacgg aaaacggctt gtgatcgtct gtccgatata atcgctgacc gtaacaatct 2583121 gcgctacgga gtcgatgcaa atctcgcctt ccgcctggct gattttatcg taagcgaaca 2583181 tttcattgtg aacgcttaaa ataaaaacag catccggcgc ctgtttcttc aatttcggaa 2583241 cccagcttgg gcgattacaa acatgcacaa gatcaaaacg gctctttttc agctctgctc 2583301 caacggcttc ttcataacgg tcttcatcca aatgcacata atggacaccg tctaccttct 2583361 ctctatcagc gagattcgga tctttaatag aaaacacagt cacctcatgt ttttttgcaa 2583421 ttaaaggggc aaccgcttcg aggtagattt gaatggcgcc tcctcgaacc gatgggacag 2583481 gaagcttctc tgtggcgatc agtgctattt tcatacatag cctccattcc tgcatgattt 2583541 ttaactagtt agaatcatga tacggctgaa caaccaactt gtgcggaatg ggactgccct 2583601 aaaaacaaaa cgggtaaaca accagattca tctattaaat atagtcaaat aactcaatca 2583661 ttttttcctt ttgattcata aggtaggagt aaaacaggta aggatgtgtc ctttaatggc 2583721 agaaaaccat gaagtcattg aggaggggaa ttcatcagag cttcctttat cagcagaaga 2583781 tgcaaaaaaa ttaacggagc tggctgaaaa tgtgcttcaa ggatgggatg tgcaggctga 2583841 aaaaatagac gtcattcagg gaaaccagat ggcgcttgtc tggaaggtcc acacagactc 2583901 cggcgcggtt tgtctaaaac gaatacacag gccagaaaag aaagcgttgt tttccatttt 2583961 cgcgcaggac tatttagcaa aaaaaggcat gaatgttcct ggcatactcc caaacaaaaa 2584021 aggcagccta tattctaagc acggctcatt tctatttgtc gtatatgact ggatcgaagg 2584081 aagaccgttt gagctgactg taaagcagga cttggagttt atcatgaaag gccttgctga 2584141 ttttcataca gcttccgtcg gatatcagcc gccaaatggc gttcccatat ttaccaaatt 2584201 aggtcgctgg ccgaatcact acacgaaacg atgcaaacag atggaaacgt ggaagctgat 2584261 ggcggaggcg gaaaaagaag atcctttctc acagctttat cttcaggaga tagatggctt 2584321 tattgaagac gggctgcgca tcaaagaccg gcttttgcaa tcgacctatg ttccatggac 2584381 tgaacagctg aaaaaaagcc ctaacctttg ccaccaggat tacggaaccg ggaatacact 2584441 cttaggagaa aatgaacaga tttgggtcat cgacttagat accgtatcat ttgatctgcc 2584501 tattcgcgat ttgcgcaaaa tgattattcc gcttttggat acgacgggtg tttgggatga 2584561 cgaaacattt aatgtcatgc tgaacgcata cgaatccaga gccccattaa ctgaagaaca 2584621 aaaacaagtc atgtttattg atatgctgtt tccttacgag ctttacgatg tcattcgcga 2584681 aaaatacgtc cgcaagtctg ctttaccgaa ggaagaatta gaatcagctt ttgaatatga 2584741 acgcattaaa gcaaacgcat tgcggcagct tatttaagac catcatttcc cccgcatatc 2584801 gggggtttga tatttataag ataaagggta attaaataca tgcggaggtt gcaaatatga 2584861 aaaagattgt cggcgcttta gccgtttttg tgattacata tgcgctgttt tcagccgcag 2584921 gctacctgtt tcctgtggac caagaatggt acaattcatt gaaaaaaccg gactggacgc 2584981 caagcggaac tgcgatcggc atcatttggg ccatcctgtt tgccctgatc tccctttcag 2585041 cagccattgt atatgctgcg ttttcattta aaggtgcgaa aagcttttgg tttacacttt 2585101 tgataaatta cgtgctcaat caagccttca gctatttcca gtttacgcaa aaaaatctgc 2585161 tggctgcatc gcttgactgc ctgcttgtcg ccatcacagc aatcgtatta ctgatcattg 2585221 ccaaaaaata cagcagagcc gcaagctatc ttcttttgcc ttatttttta tggagtgcat 2585281 ttgcgacgtt cttatccttt acaatcaatt caatgaatct gtgaacaaaa aaagccgctt 2585341 atacagcggc tttttcacat catcggcttg atgccccaaa tgtccttcgc atattcccgg 2585401 atcgtgcggt cgctggagaa atatccagaa tgagcaatgt ttacaatcga atgctcagac 2585461 catttccttc gctctcgata atcagcttga attcgctcct gtgcatctgc atatgagctg 2585521 aaatccttca gcacaaaata ctcatcatta tgcggaagca gcgagtcaaa gatcgattca 2585581 aattcatctg cctctccttc aaaaaaacca ttgatcaact gatccgctac ctgcctgatt 2585641 ctcctgtcat gctgataata ttccctcgac ctatagccgc cgttttcctg atacgataga 2585701 acctcatccg cctttaagcc gaacgtgtaa atacagtcag ggcccacccg ctcaaggatc 2585761 tcgatatttg cgccgtcatg cgtgccgatc gtcaaagccc cgttcatcat aaacttcata 2585821 ttccctgtac cagacgcttc cttgcttgcg gttgaaattt gctcacttac gtctgatgcc 2585881 ggaaaaattc gctcagccat agaaactcta taattttcta aaaaaacaac tttgatcagc 2585941 tgtttgaccg ccggatcata attgactttt tctgcgacag aatggatcag cttaatgatt 2586001 ttcttggcat aataatagct tggtgaagcc tttgccccga aaataaaggt ttgcgggtag 2586061 attgaaaacc ccgaatcctc cttgaggcgg ttatacaaat acataatgtg aagaacattc 2586121 agcagctgcc gtttatatgc atgaagccgt ttcacctgta cgtcgaatat gctctcaggg 2586181 ttcacaacca ccccggccgt gcaaaaaatc aaatcggcaa gctcttgttt tttcttgctt 2586241 ttgttgtttt gaaactgttc aataaatgca ggatcagtgg cgtacggttc taaacggatc 2586301 agtgattccg gctgcttgac ccattcatcg ccgatcgcct ctgtaatgat ggcagacaag 2586361 cctggattcg cttttaacag ccagcgcctg tgggcaattc cattcgtctt attgttaaaa 2586421 cgattcggaa acagcaagtg aaagtcgcgc atctcccttt cctttaatat atcggaatgt 2586481 atttttgcaa cgccatttac actgtagctg cctactatgg ccagatgagc cattttgaca 2586541 acaccatgcg ctgtaatcgc catgttctct atccttttcc agtctccagg atacttttcc 2586601 caaactgcac ggcaaaacct ctcattgatc tcttcaataa tcatgtacat tcgcgggagc 2586661 agcggcttaa acaaatgaat cggccatttc tcgagcgctt ctgacaatgt tgtatgattt 2586721 gtataagaaa tcgtatgtac agtgatatgc caagcttctt cccagctcat gttctcttca 2586781 tcgagcaaaa tccgcattag ctcaggcacc gcaagcgcag ggtgagtgtc attaatatga 2586841 atgctcactt ttttatgcag gccggataaa gatttatgtg ttttacggta attgttcaca 2586901 atgcttttta agcttgcgca tactaaaaaa tactgctgct tcagccgtaa aattttcccc 2586961 tcatcatggg tgtcatcggg atataagaat tcagaaaccg cttctgtttc tcgcttataa 2587021 gacaaaatat taccgccgtg ataatgggca tagggctcgg cgttccaaag ccttaacgtg 2587081 ttgacagtgc ccgtttcata gccgatgatc gggatatcat aaggaacagc ggtaacaatt 2587141 gtcgcttgtt catggcgaaa atgcaggcgc ccgctttttt ctgtcatatg gacttcgccc 2587201 caaaacggca cgtccactgc ttgatccgca ttccttactt cccatacgtt cccgtttttc 2587261 agccattgct caggcagctc cacctgatgt ccgtctacaa ttttttgctc aaacaaacca 2587321 tgcttataac gtatgcccat gccgtgccca ggcaggttca acgaagcaag cgaatctaaa 2587381 aagcaagcgg ccaagcgccc aagtccgcca ttgccgagac ctgcatcgtt ctctatctga 2587441 aggatctcct ctaaattgat gccgatttcc tttaaaccag cttctacaac atcacgaaca 2587501 ccaagattca ttaagttttg ctcaaggagc tgaccgagca gaaattcgat tgataaataa 2587561 tatgtctgct tcccggaatt tgatctgctt ttttcattcg tttcgatcca atcagcgctg 2587621 atatactctc tgaccatatt gcccaacgtt ttatattgat ccagcttggc agaatcttta 2587681 aagctttttc cgcacgtcat ttccagacgc tttaaaaata agtctgcaaa gcgttcttta 2587741 ctcgagaaca tcccgtccac tccttgtcac ctgctcgaaa atacgctgat actctttagc 2587801 cgacttcccc cagctgtaat ctgcattcat agcggtcttc acgatgctct tccatacatc 2587861 ctgttggcaa taaaacgaca gcgccctttc tatcgtaaat ttcagatcat gcgcattaaa 2587921 ggcggaaaac gtaaagccat tgcccgttcc ctcttcctcc tgataggcac ggacagtgtc 2587981 gtaaagaccg cccgtttccc tgacaatcgg aatggcgcca tattgaagag caatgagctg 2588041 ccccaaaccg cacggctcaa atttcgacgg catcaaaaac atatcagagc ccgcataaat 2588101 ttgatgggct agcggctcat caaacccgat ataagcccgg cacttctcat gaaaagcaaa 2588161 ttctgcatac cggaaataat cttcaaattc acgttctcct gtgcctagca caaccagctg 2588221 tatgtcttgc tcctcaagaa gttcgtgcat aattctgcgg acaagatcaa gccccttttg 2588281 tttagtgagc cttgtcacca tactgatcag cggaatatcg tttttctctg gaagccccat 2588341 ccgctgctga agcttcgttt tgttttccag cttgcatgca agatcccctg aatcgtattg 2588401 cgcctctata taagggtcgc ttttcggctg atagaacgta tcatcaatgc catttaatat 2588461 gccggttaca tcatcttccc tatattgcaa aacctgttcc aactgctcac cataatacgg 2588521 cgtcatgatt tcatttctgt aagtggggct cacagttgtc acatgatcag ccgcaatgat 2588581 gcccgctttc ataaaattaa caaatccgtt gcattctaac ctttcataat gaaaatgatc 2588641 catctcaaga cccagcaagt catgtgtgac atcaggaggg aatatgcctt gaaactgcag 2588701 gttgtggatc gtgagcacgc ttttcatccg ttcataaaaa ggatgttttc tgtactcctc 2588761 tttcagcaaa taattgacca tcgctgtatg ccaatcgtga gtatgaacaa tatcggcttg 2588821 aacattcaca actttggcag cctccagcac agctcttgaa aaaaaggcaa accgctcacc 2588881 gtcatcataa tgcccgtaca acgaatccct gttgaaatag tactcattgt cgatgaagta 2588941 ataattcaca tcattctctg ccatatgttc aattccgcaa tattgctgcc gccagccgac 2589001 agctacggta cactcagcct gttttttcat acgctttttc cacggttcag gtatttggct 2589061 gtacttcggc agcatcacag ctacctcatt gcctaatcgc gcaagcgcct ttggcagagc 2589121 acctgctaca tcggcaagac ctcctgattt cacaaatggg gtgcattctg acacagcaaa 2589181 taatatcttc aagaattcat cagctctcct tgcaccaaac cttttcttaa tacaagcggc 2589241 tgctcagctg ttcctgcagc ttccgtcgcc ttgccgattt taacatcctt atccgaaatg 2589301 acctgctcaa gaagacaatc ctctccaatc tgcgtttttt gcataataat gcagtttttc 2589361 agcttcgtac cctttccgac atggaccgcc ctgaacaaaa tgcagttttc aacctctcct 2589421 tcaagcacac agccgtttgc caccaaagaa tttttgacag tgctgtgctt tccgtatttc 2589481 gtaggcggct catccttcac ttttgtatag atcggctgct gcggcaaaaa cacctgctgc 2589541 caaaaacgag gctgaatgag ctccatactg tgggtataat atttttccac cgaatcaatg 2589601 acagcggcat aacctgaata ttcataaggg caaatggtca gggcggaaga ttccttttca 2589661 acagcctcct gaatggtttt atagcctttt tcgctatgtc cgtagatcag atcctttaaa 2589721 agcgttgttg acatgatata gatttgcagc gactggccgt cctgaaatac ctcggtgacg 2589781 tcgcagccaa cctcctgatg gcgtttcagc acatattgaa attgaatgtt gcatacggta 2589841 tggctgttgg agattacagc atattgctga gtgcttctgt ggaagtaatc tagatggtcc 2589901 gaaaactggc gaaaggaacc gaattcatcg tattcgtgat gaagatgggg agacgggaaa 2589961 aaaaagaggc cgtccttttt ccggtgcaaa tcccattcct tacccgcccc aaggtgatcc 2590021 atgagcgaac ggtaacgata cttcggaaaa attgcaacac tcctaatatc cgcattcacc 2590081 atgttggaaa gcataaaatc aatcagtcgg tacctgccgg caaaagggat cgccccgagc 2590141 gaccgctgtg ctgttaaatc ctgaagagaa tgcttatatg tggtttcatc tataacacct 2590201 aacatttgat tattgaacac tgactctgcc ccctcttcag taattaaatc aattcttttt 2590261 ctacaaattc ctctgaaacg agcagcacct cttcaatgtc tttttcggag cgaatcactg 2590321 cgccatccgg cagcaccatc ccattaggaa cgatggcatt ttcaatgact acatgctccc 2590381 caatcgtcac atccggcatt atgacggatg atgtaacagt cgtatgctta ccaacagtca 2590441 caccttgaaa aagaacggag tgagacacat ttccatatac aacacaacct tcgttcacaa 2590501 gcgaatcttg aacctgcgca tcagatgaaa taaattgcgg aggctgattt ggattgacgg 2590561 agtaaatttt ccatttgcgt tcaaacagct tcagctccga gtcctctttt aacaaatcca 2590621 tattggcttc ccacaagctc tgcaccgttc cgacatcctt ccaatatccc ttgaacggat 2590681 aagcagaaag cttctttttc tcttccaaaa gcagtggaat aatgtctttg ccgaagtcgt 2590741 ggctagaata agggttttga tcgtccatct caagatactg tttcaaaagc ggccaattga 2590801 atatataaat tcccattgag gcaagattgc tcttagggaa tttgggcttt tcatcaaaat 2590861 gtgtgatcgt cccatctgga ttggccttca tgatgccgaa ccggcttgct tcctcccagc 2590921 ccacttcgat gacagagatg gtcacatctg ctttcttttc aatgtgataa tcaagcattt 2590981 tgccgtagtc cattttgtat atgtgatctc ctgataaaat cagtacatac tcaggatcat 2591041 actgattcaa ataattgaga ttttcataaa tggagcttgc cgtcccttta taccatttga 2591101 cttctgatga ctcggcataa gggggtaaaa ccgtcacgcc gccattatat ctatccaggt 2591161 cccatgcact gccgatccca atataggaat tcagctcgag cggctgatat tgcgttaaaa 2591221 tcccgactgt gtctatgcct gaattagaac agttgcttag ggtaaaatca ataatcctgt 2591281 attttccccc gaaagataca gccggtttgg ccatattttt tgttaatccg ctgagacggc 2591341 tgcccttccc gccggcaagg agcatggcta cacattgttt tttcatcttt ttatctctcc 2591401 tcttttttta accgcccgta aaatcgagat gccgtaaggg gggatggtca tcgtgatata 2591461 acacggttta tgatgaagtg ctcccttttt agccgataac ggctttttgt tgatttgccc 2591521 tgagcctcca tatgtttcac tgtcactgtt aagcacttca atgtattgag taaaaaaagg 2591581 aactccaaca tcatattgat gatagaccac gggtgtaaaa ttacaaatga tgacaagcgc 2591641 ctcaccgtgc ttttggccat aacgaataaa agaaaagatt gattgttcgt cattatggac 2591701 atcaatccat tcaaacgatt gtgcacgatg gtcatgctca taaaggattt tgcttttttg 2591761 gtaaaagcgg agaagatctt gcgtaaaaac gctggctttc tgatgcatgg ggaaggagtc 2591821 caaaaaccaa tcaagctgtt ctgtatcttt ccattcatca aattgagcaa actctgatcc 2591881 cataaagatc aatttctttc cgggatgcac tgtcatatag cccagcaaaa gccgatactg 2591941 ggcaaatttc tgccagtagt cgccaggcat tttattgaga agtgattttt ttccgtatac 2592001 gacttcatca tgagaaaacg gcaatacaaa atgttcacta aacgcatata gtaatgaaaa 2592061 agagataagc tgatgacaat gccgcctttc ttcgggcggc gtctccatgt atttcagtac 2592121 gtcattcatc catcccatat tccatttata atgaaaacca agcccccctt cctcaacggc 2592181 acctgtcact tgaggccatt ctgtagaatc ttctgcaatc atcatcacat ggggatatgc 2592241 ctctctcatg gtttgattga gtttttttaa aaaatcaaca gcatatggat tcgtgtggcg 2592301 ttcatcctga tttggccaat acaagatatt agccactgca tcaaccctaa atccatctat 2592361 atgatagaat tccgcccagt acaacgcatt cgaaattaaa aaactatgaa cttccggttt 2592421 ccccaggtca aagtttgccg tgccccataa ccagttctcc cgatcacgtt cttctttgta 2592481 ttcataaagc ggttctccat caaacatata aaggccatgt gcatctttac aaaaatgtcc 2592541 ggggacccaa tccaaaatga ctccgatatt ttgttgatga cattcatcca caaacttcat 2592601 cagatcatgc ggcgggccaa acctgcttgt cgggctgtaa taccccgttc cttggtaccc 2592661 ccatgaacga tcatatggat gctcatacac gggaagcagt tcaatatggg taaacccatg 2592721 cttcttgata taagggataa gcgtctgact taattcttta taggaataat gcctgccatc 2592781 agaatgcttc ttccaagacc caagatgcag ttcataaatg aaaacaggtt tttcatacag 2592841 cgtcttagcc ttctgtttct tttgccattt ttgatcttgc cagctgtatc cttccaaatc 2592901 gtaagtaagt gacgctgtgt ttggtctgac ttctgaataa atagcgtatg gatctgcctt 2592961 cagcctgatc tcaccgttat tcgtcacaat ttcgtattta tatcgttcct tttctcctat 2593021 acctggaata aataacgtcc aaatgccatt atcattcact ctgtgcatca catgctcttc 2593081 tccagaccag ctgttaaaat ctccagccac tcgtacttcc gacgcatgag gcgcccacac 2593141 acagaattca tatccgcttt tgccattcag ctcgcggtaa tgcgagccaa acagctgata 2593201 gcttttaaac agactgcctt cgtgaaaaag ataaacatca tgtgctgtcg ggctggcagc 2593261 ggccatgtaa tcatcctttc tgacatcata gttttcattt atagtattta ttcgaagaaa 2593321 taaaaaaaag ccctttcctg aaagcgctta tacttataga caattaactt cattttctga 2593381 agaaaaacga aatatatgga gatttttgta gtctgttttt aaaataaaga acaaaatcta 2593441 agacatatca tgatttataa aaacaaaaaa accttgcagg atatgcaagg cttctggatg 2593501 acccgtacgg gattcgaacc cgtgttaccg ccgtgaaagg gcggtgtctt aaccgcttga 2593561 ccaacgggcc gataattatg atatctgtaa tcatatggcg gagaaggagg gatttgaacc 2593621 ctcgcgccgc ttacacgacc tacaccctta gcaggggcgc ctcttcagcc acttgagtac 2593681 ttctccattt ggctccacag gcaggattcg aacctgcgac cgatcggtta acagccgata 2593741 gctctaccac tgagctactg tggaacaaaa gtcatggtgg gcctgaatgg actcgaacca 2593801 tcgacctcac gcttatcagg cgtgcgctct aaccagctga gctacaggcc catgacgata 2593861 tagaaatgga gcgggtgatg ggaatcgaac ccacgacatc agcttggaag gctgaggttt 2593921 taccactaaa ctacacccgc aatttttatt tggggcgatt gatgggaatc gaacccacga 2593981 atgccagagc cacaatctgg tgcgttaacc acttcgccac aaccgccaaa gcatattgat 2594041 aaatggtggc tcgggacgga atcgaaccgc cgacacacgg attttcagtc cgttgctcta 2594101 ccaactgagc taccgagcct aagtatttaa atggcggtcc ggacgggact cgaacccgcg 2594161 acctcctgcg tgacaggcag gcattctaac caactgaact accggaccat tttaaaattt 2594221 ggttgcgggg gcaggatttg aacctgcgac cttcgggtta tgagcccgac gagctaccga 2594281 actgctccac cccgcgatga ttaggaatat gtatggcgga ggaagaggga ttcgaacccc 2594341 cgcgggcttt gacacccctg tcggttttca agaccgatcc cttcagccag acttgggtat 2594401 tcctccgtat agtggtggac cttgtaggac tcgaacctac gaccggacgg ttatgagccg 2594461 tctgctctaa ccaactgagc taaaggtcca ttggtagcgg cggaggggat cgaacccccg 2594521 acctcacggg tatgaaccgt acgctctagc cagctgagct acaccgccaa atatttttga 2594581 aatcaagtgg agcctagcgg gatcgaaccg ctgacctcct gcgtgcaaag caggcgctct 2594641 cccagctgag ctaaggcccc aagaatggtc gggaagacag gattcgaacc tgcgacccca 2594701 tggtcccaaa ccatgtgctc taccaagctg agctacttcc cgatttcata tagatcatgg 2594761 cgcgcccgag aggagtcgaa cccctaacct tttgatccgt agtcaaacgc tctatccaat 2594821 tgagctacgg gcgcaaaact taatgccgag ggccggactt gaaccggcac ggtagtcacc 2594881 taccgcagga ttttaagtcc tgtgtgtctg ccaattccac caccccggcg tggatggtat 2594941 agttggagcg gaagacggga ttcgaacccg cgacccccac cttggcaagg tggtgttcta 2595001 ccactgaact acttccgcag aaatggtgcg gatgaaggga cttgaacccc cacgtctgta 2595061 aagacactag agcctgattc tagcgcgtct gccaattccg ccacatccgc aacatgtaaa 2595121 tggtgagcca tgaaggactc gaaccttcga ccctctgatt aaaagtcaga tgctctacca 2595181 actgagctaa tggctcttct tacaatagac ttgaatatta tatcatataa aagtggtgcc 2595241 ggcaagagga cttgaacccc caacctactg attacaagtc agttgctcta ccaattgagc 2595301 tacaccggca tatatgtaaa accgatatgt ataatgaaaa atggtggagg atgacgggct 2595361 cgaaccgccg accctctgct tgtaaggcag atgctctccc agctgagcta atcctccata 2595421 cttgcactaa cgtgcaattg cttggcggcg tcctactctc acagggggaa acccccgact 2595481 accatcggcg ctgaagagct taacttccgt gttcggtatg ggaacgggtg tgacctcttc 2595541 gctatcgcca ccaaacaaat tgagagtgtt ctctcaaaac tagataacag gtgtgacatc 2595601 attcaaaaat atggttaagt cctcgatcga ttagtatctg tcagctccat gtgttgccac 2595661 acttccacct cagacctatc aacctgatca tctttcaggg atcttacttc cttgcggaat 2595721 gggaaatctc atcttgaggg gggcttcatg cttagatgct ttcagcactt atcccgtccg 2595781 cacatagcta cccagcgatg cccttggcag aacaactggt acaccagcgg tgcgtccatc 2595841 ccggtcctct cgtactaagg acagctcctc tcaaatttcc tgcgcccgcg acggataggg 2595901 accgaactgt ctcacgacgt tctgaaccca gctcgcgtac cgctttaatg ggcgaacagc 2595961 ccaacccttg ggaccgacta cagccccagg atgcgatgag ccgacatcga ggtgccaaac 2596021 ctccccgtcg atgtggactc ttgggggaga taagcctgtt atccccgggg tagcttttat 2596081 ccgttgagcg atggcccttc catgcggaac caccggatca ctaagcccga ctttcgtccc 2596141 tgctcgactt gtaggtctcg cagtcaagct cccttgtgcc tttacactct gcgaatgatt 2596201 tccaaccatt ctgagggaac ctttgggcgc ctccgttacc ttttaggagg cgaccgcccc 2596261 agtcaaactg cccacctgac actgtctccc cgcccgataa gggcggcggg ttagaaggtc 2596321 aatacagcca gggtagtatc ccaccgatgc ctccaccgaa gctggcgctc cggtttccaa 2596381 ggctcctacc tatcctgtac aagctgtacc aacattcaat atcaggctgc agtaaagctc 2596441 cacggggtct ttccgtcctg tcgcgggtaa cctgcatctt cacaggtact ataatttcac 2596501 cgagtctctc gttgagacag tgcccagatc gttgcgcctt tcgtgcgggt cggaacttac 2596561 ccgacaagga atttcgctac cttaggaccg ttatagttac ggccgccgtt tactggggct 2596621 tcaattcgca ccttcgctta cgctaagcgc tcctcttaac cttccagcac cgggcaggcg 2596681 tcagccccta tacttcgcct tacggcttcg cagagacctg tgtttttgct aaacagtcgc 2596741 ctgggcctat tcactgcggc tctctcgggc ttgcacccta acagagcacc ccttctcccg 2596801 aagttacggg gtcattttgc cgagttcctt aacgagagtt ctctcgatca ccttaggatt 2596861 ctctcctcgc ctacctgtgt cggtttgcgg tacgggcacc tctcacctcg ctagaggctt 2596921 ttcttggcag tgtggaatca ggaacttcgc tactatattt cgctcgccat cacagctcag 2596981 ccttatggga aacggatttg cctatttccc agcctaactg cttggacgcg gatatccaat 2597041 accgcgctta ccctatcctc ctgcgtcccc ccattgctca aatggtgagg aggtggtaca 2597101 ggaatatcaa cctgttgtcc atcgcctacg cctttcggcc tcggcttagg tcccgactaa 2597161 ccctgagcgg acgagccttc ctcaggaaac cttaggcatt cggtggaggg gattctcacc 2597221 cctctttcgc tactcatacc ggcattctca cttctaagcg ctccaccagt ccttccggtc 2597281 tggcttcaca gcccttagaa cgctctccta ccactgttcg aagaacagtc cgcagcttcg 2597341 gtgatacgtt tagccccggt acattttcgg cgcagagtca ctcgaccagt gagctattac 2597401 gcactcttta aatggtggct gcttctaagc caacatcctg gttgtctaag caactccaca 2597461 tccttttcca cttaacgtat actttgggac cttagctggc ggtctgggct gtttcccttt 2597521 cgactacgga tcttatcact cgcagtctga ctcccaagga taagtcattg gcattcggag 2597581 tttgactgaa ttcggtaacc cggtaggggc ccctagtcca atcagtgctc tacctccaag 2597641 actcttacct tgaggctagc cctaaagcta tttcggagag aaccagctat ctccaggttc 2597701 gattggcatt tcacccctac ccacacctca tccccgcact tttcaacgtg cgtgggttcg 2597761 ggcctccatt cagtgttacc tgaacttcac cctggacatg ggtagatcac ctggtttcgg 2597821 gtctacgacc acgtactcat gcgccctatt cagactcgct ttcgctgcgg ctccgcatct 2597881 tctgcttaac cttgcacggg atcgtaactc gccggttcat tctacaaaag gcacgccatc 2597941 acccgttaac gggctctgac tacttgtagg cacacggttt caggatctct ttcactcccc 2598001 ttccggggtg cttttcacct ttccctcacg gtactggttc actatcggtc actagggagt 2598061 atttagcctt gggagatggt cctcccggat tccgacggaa tttcacgtgt tccgccgtac 2598121 tcaggatcca ctcaggagag aacgaagttt tgactacagg gctgttacct cctatggcgg 2598181 gcctttccag acctcttcat ctacctcgtt cttttgtaac tccgtacaga gtgtcctaca 2598241 accccaagag gcaagcctct tggtttgggc tgatcccgtt tcgctcgccg ctactcaggg 2598301 aatcgcattt gctttctctt cctccgggta cttagatgtt tcagttcccc gggtctgcct 2598361 tctcatatcc tatgaattca gatatggata ccactccatt acgagtggtg ggtttcccca 2598421 ttcggaaatc tccggatcaa agcttgctta cagctccccg aagcatatcg gtgttcgtcc 2598481 cgtccttcat cggctcctag tgccaaggca tccaccgtgc gccctttcta acttaaccgt 2598541 taaaaagaat cactatgtga tatcttgtgt tactaattga atgtgatgtc tactgttatc 2598601 tagttttcaa agaacacgtt tcgaaggaat gatccttcaa aactaaacaa gacagggaac 2598661 gttctgttta taagaccttg ggtcttatat tccgtataat atccttagaa aggaggtgat 2598721 ccagccgcac cttccgatac ggctaccttg ttacgacttc accccaatca tctgtcccac 2598781 cttcggcggc tggctcctaa aaggttacct caccgacttc gggtgttaca aactctcgtg 2598841 gtgtgacggg cggtgtgtac aaggcccggg aacgtattca ccgcggcatg ctgatccgcg 2598901 attactagcg attccagctt cacgcagtcg agttgcagac tgcgatccga actgagaaca 2598961 gatttgtggg attggcttaa cctcgcggtt tcgctgccct ttgttctgtc cattgtagca 2599021 cgtgtgtagc ccaggtcata aggggcatga tgatttgacg tcatccccac cttcctccgg 2599081 tttgtcaccg gcagtcacct tagagtgccc aactgaatgc tggcaactaa gatcaagggt 2599141 tgcgctcgtt gcgggactta acccaacatc tcacgacacg agctgacgac aaccatgcac 2599201 cacctgtcac tctgcccccg aaggggacgt cctatctcta ggattgtcag aggatgtcaa 2599261 gacctggtaa ggttcttcgc gttgcttcga attaaaccac atgctccacc gcttgtgcgg 2599321 gcccccgtca attcctttga gtttcagtct tgcgaccgta ctccccaggc ggagtgctta 2599381 atgcgttagc tgcagcacta aggggcggaa accccctaac acttagcact catcgtttac 2599441 ggcgtggact accagggtat ctaatcctgt tcgctcccca cgctttcgct cctcagcgtc 2599501 agttacagac cagagagtcg ccttcgccac tggtgttcct ccacatctct acgcatttca 2599561 ccgctacacg tggaattcca ctctcctctt ctgcactcaa gttccccagt ttccaatgac 2599621 cctccccggt tgagccgggg gctttcacat cagacttaag aaaccgcctg cgagcccttt 2599681 acgcccaata attccggaaa acgcttgcca cctacgtatt accgcggctg ctggcacgta 2599741 gttagccgtg gctttctggt taggtaccgt caaggtaccg ccctgttcga acggtacttg 2599801 ttcttcccta acaacagagc tttacgatcc gaaaaccttc atcactcacg cggcgttgct 2599861 ccgtcagact ttcgtccatt gcggaagatt ccctactgct gcctcccgta ggagtctggg 2599921 ccgtgtctca gtcccagtgt ggccgatcac cctctcaggt cggctacgca tcgttgcctt 2599981 ggtgagccgt tacctcacca actagctaat gcgccgcggg tccatctgta agtggtagcc 2600041 gaagccacct tttatgtttg aaccatgcgg ttcaaacaac catccggtat tagccccggt 2600101 ttcccggagt tatcccagtc ttacaggcag gttacccacg tgttactcac ccgtccgccg 2600161 ctaacatcag ggagcaagct cccacctgtc cgctcgactt gcatgtatta ggcacgccgc 2600221 cagcgttcgt cctgagccag gatcaaactc tccgataaat ggatcacagg ttaagttcac 2600281 cgcatcctgc ggcgacacct gtgtgacctg cgtcgtgcag gccctagttt gactgactac 2600341 gcacatcgca gtgcgatttt taaaaactga attaacaggt acgttttgtc ttgtttagtt 2600401 ttcaaagatc atttcgttac ttctcaatga agcagcttta ctaatataac attcagcttc 2600461 ttttttgtca acaacttttt tcaagttgtt ttgaagcatc tagtttgtgt ccgctgtgca 2600521 tcagcgacgt ttaataatat aacacctgta tttatttatt gcaatagttt tttaaaaaaa 2600581 atctataaaa caaataaact ataatcctcg ccatgatttc taaagcgtgt gtatcatata 2600641 agtttcttaa aagaacatat acatcagtca tgtgatcttg ttgttttttt cgttttcttg 2600701 tatagtagaa acgaactaaa tactgatgac cacaagggga gcattaaagc tgagagtgag 2600761 cggtttcgtt ctgacccttt gaacctgtta gttaacgctg gcgtagggat gtggcaaagt 2600821 caaatgaatt gcagatcgta aagcagtgcg tggaactttt ctcatccttc cgcgtgctgc 2600881 ttttttgttg tccttttggt tgtctgtcaa tggaaggaga tagatatgaa tcaatctaag 2600941 caactggttc gccttattga aattgccatt atgacagcgg cagccgttat tttagacatt 2601001 gtctcaggaa tgtttcttag catgcctcaa ggaggctcgg tctccatcat gatgattccg 2601061 atctttttaa tttcgtttcg ctggggtgtc aaagcaggtc ttactacagg tttgttgaca 2601121 ggtctagtac aaatagcaat cggaaacttg tttgctcaac atcctgtaca gctattgtta 2601181 gattacattg tcgctttcgc agcaatcggc ataagcggct gtttcgcttc ttctgtccgt 2601241 aaagccgctg tatcaaaaac aaaagggaaa ttgattgttt cagtggtcag cgcagttttt 2601301 atcggcagtt tgctgcgcta tgccgcgcat gtcatttcag gagctgtgtt tttcggcagc 2601361 tttgctccaa aaggaacacc ggtatggatt tattctttaa cttataatgc gacttacatg 2601421 gttccttcat tcattatttg tgcaattgtc ctatgtttat tatttatgac agcaccccgt 2601481 ctgcttaaaa gtgacaaagc gtaaaagtaa caatccccca gcgaattccg ctgggggatt 2601541 tttcgttatc tgttaagaag tgtttttaaa gctgaaagat ccggccagcc aagacctact 2601601 tctttcagcc ttactccggc aatttcaaag ttgtcctccg ctactctttc aggtgaatag 2601661 gcctgataaa atataatcga gggattctgc tcaataaccc aaacaaacat acttgaaaaa 2601721 ccatgttgaa gcaaaaactc cgctcctttt gctaagagcg ccctgcctgc accttgccgc 2601781 tggcgctctt ccagaagata aatagcgtat aactcgccgt catagccttc ttgttcagag 2601841 cgaataggtc caaatgaagc aaagccgaat actgaaccct tttcgtcctg agcaacaaat 2601901 actcccttta acgagcgact tttccatttg tcttcaaatt ccttatagtt caggctgttt 2601961 aaataatcaa tcgggataat ttcgtggtat gttgtcctcc agctgtctac atgcactttt 2602021 gcaatgtcct ttatatcctc taacttcgct tcacgtacag ttaccatacg gttctgccct 2602081 ttccttactc tgatttttgg atcgttttgg cttctttgat ttcatttgtt aattcattaa 2602141 tgctttgttt tacgtttcct tttcctgaaa agttctcaag catttctttt acatcaattc 2602201 ctgaggatgc ttttaaactt tcttgcagac ttgacattaa gttcgtcgca tagctggtta 2602261 ctttgtttgc tccgcttgat tcaccgcttc ctcctgtatc gacaacggtg attttatcaa 2602321 tatttgaaag aggtgccgct gcttgtttcg cgtattccgg aagcattttg acaatcatat 2602381 cgaaaatcgc cgcctgcccg tactgttcaa aggcggccgc aattttctct tttgcttccg 2602441 cttctgcaag acctttcagg cggataacct ctgcttctgt ctctcctttc gctttttccg 2602501 cttctgcttt tgctagcccg tcaattctta ctttttccgc ctcagccttt gccattgctt 2602561 caatactgta cttcttggca tcggcttccg cgagctgttt ggctttctca gctgctgcgg 2602621 actgctcaac agaataacgg tctgcatcgg cttttttctt tacctctgag tcgtattgac 2602681 gttcacggcg aagaatttct ttttcttcta gttctatttg tttttggcgt tcgataattt 2602741 taacctgcat ttcctgctct gtgacttgct ggcgcgctcg ggcagtctct aaatcatatg 2602801 cttggtcggc attcgctttt gccgtatctt gttctctgcg gaattcagcc attttgagct 2602861 gattgatttt ttcagcttca gcgatttccg tcgcccgttc aagttctgat ttttttgcgt 2602921 ctttatcggc ttctgcccgc ttaattcggg tttctttatc agcctctgct gttgcgatat 2602981 cagcatcgcg ttttacttgg gcaattctcg gtttccctaa tgattcaaga taaccgtttt 2603041 tatcacgaac atctttaatg gtaaacgaga cgattacaag tcccattttc gcgagatcct 2603101 gtgaagcgac acgctgcacc tcttgagaga atttttctct gtttttatag atttcttcta 2603161 ctgtcattga gccgagaatg gaacgaaggt ggccttctaa aacctcccgc gcttcctgct 2603221 cacggtcgtc ttttgatttc cctaaaaatt gttcggccgc tgtagcgatt tctcctatag 2603281 aaccgccgat tttaataatc gcagttccat cggccattac tggcactcct tgttctgtat 2603341 agacttcagg tgtcgaaaca tcgagtttgc ttgataatag gcttagcggc tctgcctgct 2603401 ggaagacggg aaggacaaag gttcctccgc cgcggacgat tttaatacgg ttgccgcctt 2603461 catcgacatg aacattttta ttacccagat agctccctgt tacaattaac gcttcatcag 2603521 gccctgctgt acgatacttc gtaataaaca cagctattag tgcaattaat aaaaagaata 2603581 caactccgat gatcattata atcggcattg tcatatcaaa ttcctccttt tatgttaaat 2603641 gggttcatgc ggagtaaccg aaagaactcc gttgttaata tctacgacta acaccgttgt 2603701 cccgtaactg atctgctgat tatcaaaact gaccgctgac tttgaaatgg tcccgcctat 2603761 cccttctatg accacttcac caaacccgtc aaccggcaca gctgtaatca ctttaccgag 2603821 tcttcctctg agatcatctt ctctatatgc caatgattct tctgcagatg ataatggcac 2603881 cagtacaaag atgtgaagca ataccaccag catgatcgaa aggatgcaag ataaaagcgc 2603941 aatcagcaag cttgacagag gcaatacaag ttcacctata tatccgcccg ctgaaaaaca 2604001 tgtaaaaaat gagagcacta atgtcggatt aagaaacgga atgccttctg acagccctga 2604061 aaatacatct ccgaaaaaca ggaataacag cgtaaggctg cccgcaataa taagcgtata 2604121 aagatacatt gtttgtatag gtactccaaa taactccaac ttcctcatcc tttcttcatc 2604181 aatgcattga tgaacggctg ccgttaccat ttatacgaga cacctcggga aaagtttcaa 2604241 aattttaaga caaataaccc atttgaagtg ctttataaat gataattgct tatatatatg 2604301 gtaatgtcat tttaggagga gatatgatga gtatctttaa tgaagccaga ttagaaacgt 2604361 ggaacgaatt gaaaggactt tctgacgaaa agctgaatca aaagccttct gctgaagaat 2604421 ggagcatacg ggaagttctt gaccatttga aaaaaatcga tatgaccgca caaaaaatgt 2604481 tgaaggaacg tgtaaaggac gctccgatta aagaaattga agaaaaaccg cttgaagtag 2604541 cacaggacag aaataataaa cggaaagccc cgagtcatct tgagcctgcg catgatttta 2604601 tttcaggcag ccaaatgaaa cgtgagcttg atgtggtaag agagcagctg actgctgcga 2604661 ttgcctctct gaaagaagaa gattttgaaa gagtgcttcc gcatcctgtg tttcaagagc 2604721 tgactgtcag acagtggatc gattttatcg gccatcatga aaaacggcac ctcagccaaa 2604781 tgaaagaaat taaagaaaag atagaaaggg cctgatttaa tcagaccctt tctgcttttc 2604841 gtttgacttt tcgctgatag gaatgaactt ctatttcatc acctgtgtaa acagcaccag 2604901 gtctctccac aatacagaca atccctctaa tgcccagtgc gtggcggacg aaagccgacg 2604961 ccagcttcgg ttggtccgga taataagact gaatgacttc tcccggctgg atacacggat 2605021 cattttcgcc ctcacacagc agagccgctc cgctcggaaa aataatccgg cttccttctt 2605081 ttaatgaagt aagatctggc ataccgctga ctgccacatt cgccccgagc cattccggca 2605141 aaattctcgg cactcccatt tttaaagcga tttcgttgca ttcctctatt gaaacaattg 2605201 aaatttgtct gcggttgaaa atttcagtcc ctcttgaaaa cattggttct ctggctcccg 2605261 cttttttggt caggccaaaa tgcaagtcgc cggggatgcc gccataatca aaatcaagct 2605321 tgtccatttg ctttgttacg aagctttttg tatctgcgat atataagcct tccgcttttg 2605381 cagtcatacg cttccacatc agctggcacc ttccttctta tctaaaattt ccacctatgc 2605441 ttcattatcc caaaaaatcc cgctctgtaa aggagcggga ttttgattat accgttttag 2605501 gcgtaaggtt aaagcagcgt ttgtagatcc agttgtatgc tttttcattt aaatctctag 2605561 ggtttccgaa ggtttgcgga tctttcattg cttctttaga caagcgttcg atcatatcag 2605621 gtgatactcc ctgctcttct aaagtcggca cttctaaatc ttcgaccaga tcatacatcc 2605681 aattgacaga tgctttcgca gcttcttctg ttgtcatctt gcttgtatca ataccgaacg 2605741 ctttcgcaat acgcgcaaac ttctcaggat agcccttcca gttgtattcc atgacagggc 2605801 ccatcatcgc cgctacacat tggccgtgag cgactgggat aataccgcca agcgtttggc 2605861 tcatcgcatg agcagcgccc gctgattcac ttccgtaaga aagaccggca agcatcgcag 2605921 cctgcgccat tccgtacctt gcttccagat cctctccatc agcaaatgcc ctcttgatgt 2605981 aatgagcggc atactcaatc gccattaagg caaccgcatc cgtgattggc tgtgcaaatt 2606041 tcattgtata gcactcaatg gcatgggcga gcgcatcaat tcccgtcata gctgttacat 2606101 gcggaggcat tgaaacatga agctcaggat caatgattgt caagtgcgct gcaatcagcg 2606161 gaccgcccgt gttgaatttg aattctcttt cttcatctgt gataaccgcc cattgggtta 2606221 cttctgatcc ggttccagct gtagtgggaa ttgtcgtcag cggaggaatg cggttttcca 2606281 gcggtttttt cccatctgcc gcttcataat caagcacgct tccttcgtga gtcgcttcta 2606341 ctccgattgc ttttgctgta tccatggagc ttccgcctcc gactgccacc aaaccattac 2606401 agttctcttt tttgtaaagc tcagatcctt cattcaccag acggacaggc gggtttggct 2606461 caactttatt aaagagtacc acttcaatgc ctgcttcttt aagtgattcg attacgggat 2606521 cagcaacacc ggctttataa atcccagggt ctgtgacaag gagcgctttt gaaacgccca 2606581 gtgcagctac ttcctcaccc gtatgcttga tggctccgat tccatgctta atcacagtcg 2606641 gaatttcaaa tgtgtggaat ttctgcatgc tttctacctt catatttaat gtcatcatca 2606701 atctccccct cttatgaatt aaaccagtta accgctgccg gttttgtatt gcggtataca 2606761 tgtttgactt ctgtgtattc ttcaaggcct atttttccaa gctcgcgtcc gaacccggat 2606821 tgcttatatc cgccccatgg cgcttgtgca aagtacggat gaaaatcgtt gatccaaacg 2606881 gttcccattc tcaagcgggc tgctacccgt tcgcactttt caatgtcttt tgaccatacc 2606941 gctccagcca agccatagat ggtatcattc gcaagctcga ttacctcttc ttcagagctg 2607001 aaggtttcga ctgtcaatac aggaccgaaa acctcttcct gaacgattct catgtcagaa 2607061 ttacagtttg agaaaatagt aggttcatag aaaaagccgt tttgaagctc aggatcttcc 2607121 gggcgtttgc ctcctgtctc cagcttcgcg ccttcctcta ttccgatctc tacatatttt 2607181 tctacctttg ccctgtgctc cgccgaaata agcggaccgc tttctgtctc agcatgaaaa 2607241 ccgtttccga gttttatgcg ttttgcccgt ttgaccagct ccgccaaaaa ttgatcatga 2607301 atggcatcct caacaagcaa gcgggaacct gcagagcata cttggccggc gtggaaaaat 2607361 acagcgttta aggcctgatc aaccgcaact tctaaatccg cgtccttgaa aacaatattt 2607421 gggtttttcc cgccaagttc aagggcgatt tttttgacgt ttccgcttgc cgcccgcatg 2607481 atttttttgc ctgtttcaat tccgcccgta aatgaaatca aatcgacgtc tttgtttacg 2607541 gcaagctcgt cgcccactgt ggctcccggt ccaagaacaa gatttgcgac accttttgga 2607601 acaccggctt cttccatcag cttaaagact ttgattgtcg tcagcggcgt aatctcactc 2607661 ggcttcatga cgattgtgtt tcctgcggcc agtgcagggg cgattttcca gctcgcttga 2607721 aggagcggat aattccatgg agtgatctgg ccgcaaaccc cgattggctc cctaataatt 2607781 ttgctttctg aatcaggaat cggagatgaa atgatctctc cgccatcttt gtctgccaag 2607841 ccggcgtaat attgaaaaac attggcgata tcgtccatat cggccttgct ttcttcgagt 2607901 gtttttcctg tatcaagaga ttcaagctca gccagctcct caagatcgcg tctgattaat 2607961 tccgcaattt tcagaacaat ttttccgcgt tcaagcccgg atagcgatga ccattctcct 2608021 ttgtcaaatg ctctacgtgc ggctgcgatt gctttgatgg cgtcctctcg ccctccctcg 2608081 cttacagttg caatttcttc ttgattaaat gggttgataa tactgcggat ctgttctttt 2608141 tcggcactga tccattctcc gtcaatgaat aatgtttgac tcatataagc ctccttgacg 2608201 taaataaagt ttgttaaata aaaatttaat gtttttaaca accttaatct aacatatggt 2608261 ttttaaactg tcaaagtccc attttgattt ttctttttga cttttcctca tgtttcgtta 2608321 agataaagaa cataaagaaa taacttaacg aatttaattt tctaaaggaa aagagggtca 2608381 gtatggatga aaatccagaa tttgcagcta tagaacaggc tcgggatctt gttattgact 2608441 ccattgctga aacgatggat ctttacggaa ttacccgcag tgtcgggatt ttatatggga 2608501 cgatgtatat gagggatgag atgacgcttg acgaaatgcg tgaggagttg caaatgagca 2608561 aaccaagcat gagcactggc gtcaaaaagc ttcaagactt aaatgtagtg aaaaaaacat 2608621 ttcaccgggg catccgcaag catacatttg tggctgagaa ggatttcttt aaatttttca 2608681 caaatttctt tccacctaaa tgggagcggg aggttcaagt gaatgtaaca gcgatcgagg 2608741 aagctcaagc tgatttacaa aaggttttat gcaaggaaga tctcgatgag gatatcaaaa 2608801 atgaagcact gcagttatat gatcagctgg aaagctctaa agcttactat gactggctga 2608861 aacggcttgc tgaatcggtg cagaccggag aaatttttaa atttataccg gtcgaaacaa 2608921 agtaaagcag aaaacgcctg ggaaactagg cgtttttttg atgtaactac tacaaatttg 2608981 aaaaatacgg gaaaaacacc ccatttactt ccaaaatatt tgatggtaat tttatgtagg 2609041 taaaatttgt atttggcctt tcagaggagg tgaaaagcgg gcaggcctgt ttaatttatc 2609101 attttttagg gggaattttg ttatgaaacg caaattatta tcttctttgg caattagtgc 2609161 attaagtctc gggttactcg tttctgcacc tacagcttct ttcgcggctg aatctacatc 2609221 aactaaagct catactgaat ccactatgag aacacagtct acagcttcat tgttcgcaac 2609281 aatcactggc gccagcaaaa cggaatggtc tttctcagat atcgaattga cttaccgtcc 2609341 aaacacgctt ctcagccttg gcgttatgga gtttacattg ccaagcggat ttactgcaaa 2609401 cacgaaagac acattgaacg gaaatgcctt gcgtacaaca cagatcctca ataacgggaa 2609461 aacagtaaga gttcctttgg cacttgattt gttaggagct ggcgaattca aattaaaact 2609521 gaataacaaa acacttcctg ccgctggtac atatactttc cgtgcggaga ataaatcatt 2609581 aagcatcgga aataaatttt acgcagaagc cagcattgac gtggctaagc gcagcactcc 2609641 tccgactcag ccttgcggtt gcaactaatg taaaagaccg gttaacgccg gtcttttttg 2609701 cgttttaccc tccccttttt ctctaatccc cgttatcttt tttctggttt aaaatttaaa 2609761 ttgacaaaca ctagaaacag gagtaaattc ttgagtgttc aatttcatac agtctctttt 2609821 accgcttaat caaacacgaa cgggggaacc aacgattggc tgttttatta acagccttgg 2609881 ggtgaatctt actaagtaag agggggtact ctgaatccct aatccgacag ctaacctcgt 2609941 aggcgtatac agagaggagg tctattatcg gccattcttt gcaatggtct tttttgtttc 2610001 aaaaacgtta attcactaag ggagatatga acattgggaa gaattaaaaa taagcaattt 2610061 gccgtgatcg ggctgggccg gtttggcggc agcatttgta aagaacttca tagaatgggg 2610121 catgaggtcc ttgcggttga tatcaacgaa gaaaaggtca atgcatatgc ttcttacgcc 2610181 actcatgcgg taattgccaa cgccaccgaa gaaaacgaat tgctttcatt aggaatacgc 2610241 aattttgaat atgtgattgt tgccatcgga gcaaatattc aagcgagtac gctgaccacc 2610301 ctattattaa aggagcttga tattccaaat atttgggtga aggctcaaaa ctattatcat 2610361 cacaaggtgc ttgaaaaaat aggcgctgac cgcattattc atcctgaaaa agatatgggg 2610421 gttaaaatcg cacaaagcct ttcagacgaa aatgttttga attacattga tctatctgat 2610481 gaatacagta ttgtcgagct gctggctacg cgcaagcttg attcaaaatc gattattgac 2610541 ctgaatgtaa gagcaaagta cggctgcacg atcctggcca ttaaacatca tggagatatc 2610601 tgtctttccc ccgcgcctga agacatcatt cgcgagcaag attgcctggt gatcatgggc 2610661 cacaaaaagg atattaaacg ttttgaaaac gaagggatgt agacaaaggt gacacttcaa 2610721 aaggataaag tgatcaaatg ggttcggttt acaccgcctc aagtgcttgc cattggtttt 2610781 ttccttacca ttatcatcgg ggctgtccta ttaatgcttc cgatttccac tacgaagcca 2610841 ttgtcatgga tagatgccct ttttactgcg gcttccgcta caactgttac agggcttgct 2610901 gttgtcgata ccggcactca atttacggta ttcgggcaaa cagtaattat ggggctgatt 2610961 cagattggcg ggcttggatt tatgacattt gcggtcttga tcgtcatgat attaggaaaa 2611021 aaaatcggct taaaagaacg aatgctcgtc caggaagcct taaaccagcc gacaatcggc 2611081 ggtgtcattg gccttgtcaa agtcctgttt ctgttttcga tcagtattga attgatagca 2611141 gcactcattt tatccatccg gcttgtacct caatacggct ggtcatccgg cttgtttgca 2611201 agtttgtttc acgcaatatc tgcttttaac aatgccgggt tttcgttgtg gcctgataat 2611261 ttgatgagct acgttggcga tcctacagtg aacctcgtga ttactttctt atttattaca 2611321 ggagggatcg gatttacggt tctgtttgat gtgatgaaaa atcggcgttt taaaactttt 2611381 tctttacata caaagctcat gcttacagga acgctgatgt tgaatgcgat cgctatgctt 2611441 acggtcttta ttttagaata cagcaacccc ggcacgctcg gccacctgca tatagtggat 2611501 aaactgtggg cctcctattt tcaggcagtg acgccgagaa ccgcagggtt caattctcta 2611561 gattttggaa gcatgagaga aggaacaatt gtatttactt tattattgat gtttatcgga 2611621 gcaggaagcg catcaacggc gagcggcatt aagctgacta cgttcatcgt gattttaaca 2611681 tctgttattg cttacttgag aggtaaaaaa gaaacggtta ttttccgccg ttccatcaaa 2611741 tatccgatta tcattaaagc tttagctgtg agcgtcacca gtttgttcat cgtgttttta 2611801 gggattttcg ccctgacgat cacagaacaa gcgccatttc ttcaaattgt gtttgaaacc 2611861 ttttccgcat tcggaactgt cggccttacg atggggctta ctcctgaact gacaacagct 2611921 ggcaagtgta tcatcattgt catcatgttt atcggaagaa ttggtccttt aacgttcgtg 2611981 ttttcattcg caaaaacaga gcaatcaaat atccgttatc ctgatggcga agtgtttaca 2612041 gggtgatatc aaaaaaatcc ggcgtgcagt cgccggattt tttatgattc gatatgagat 2612101 tgattttgtc ttttttcctg ttccgcgatg atttcgttat cctccgcgtt atcacgggtc 2612161 actttttgcg taagaatcgc accaactgct acaagtatca taacagcgat gtaataacct 2612221 ttttcattga gttccagatt atcagcatta tagagtccga tactaaacaa aaatactccc 2612281 gcaaaaaaag taaaataagc tagtactgta aaggcaaccg tgtttctgcg tctatatttc 2612341 tgcacctttg ttccctcccg aaagcatagt taaaaagtga taacttccgt ggaatattat 2612401 acctcaaatt ccccggaatg gaacaaagaa ttaaaaatac cagtaaaaag ggcttaggtt 2612461 gcctccttta tttcaacagc tgaatcatca atccagccga taagtttatc attgatttgg 2612521 aattggtacc atacagactg gcctttctgt tttttagaca caacctttat gtctttgccg 2612581 acgtaagatt gggcagaggt aagccttatg gaccgatcat cagtagaagg cttggaccat 2612641 acgtcttgaa cggcactgtc tttaatagag gcgtttaaat ccacagattt gagggatgga 2612701 tttacctcat cgtactcatc taaatcgtat ttttccacaa tagcgctgat tttgtcagcg 2612761 tagtcagggt ctgtagcata tcctgatgtt tgcagggcgg ttgccgcttc cttataattc 2612821 cctgcctcaa gcaccggttt atacttcttt ttattccacg atgtgccacg gacgaacaat 2612881 tgggcgtgat catccataga ttcaaaaaac gtgctgtatt ttcgaaactt cgcgcgaatg 2612941 gtttttcttt tccctttttc aacttcgtcc gtttccatcg tgacatgatg gcctttataa 2613001 ttccctttta cgccaaaaag gttgttggcc ttagcagcca gttcactgtt cccccagtcc 2613061 gattcgagaa tggcctgagc aattgtgatg ctggggagaa catggtattt ttcatacaaa 2613121 atttgggcat gtccggacag actgtctata aatacttgct gttcatcgat ttcttcagtt 2613181 tctttggata tttcaatcgg ttttgataaa gttgtcgcta aaacaaacag agctagcgga 2613241 atcgatacaa ggaaaaatag tgaaatcaag agtttacgtt ttttaagttt tttacgggcc 2613301 atgaaaacct tccttcgaat taaaagatta cgaatgtaaa agaatctacc ttttagaatt 2613361 ttacttgcac ttctaatatt tttcaattct ttagggataa agttgggaaa agattgcaaa 2613421 ataaaaacct tttcgctcaa tgaaaaggtt tttaccatgt ttctattttt gtaaatttct 2613481 gagtgcattc cgatattccg tatcatttat tactttatat gatttgacag ttgccttcga 2613541 caaaccttgt gctgagacgg ccggtttttc cggagctgtt ttcgctttat catgtggttt 2613601 atgtgccagc ttgtgcccca ttccagtggc attcatacaa aatgacaggc agacgagcag 2613661 cacgctaagg ataaaagaaa tgaagaagag atcatgataa gcagtcatca tagaatcctg 2613721 taccgaaccg ctttgtctgg cagcatcttt tttcgtgaaa aagccgatga gaatgggaac 2613781 tcccatatag acaaacaatc ttaaaaactg aacagctgtc attctcttga ccaaatcagg 2613841 cagcgggcct cccatggcag ctcccatcag ccctgcggcg actgtcaggc ctgttcccgc 2613901 tgcaagcatg ataaacagtg ccgcgaacat ataaagagat gatcgatcct gtatatgcag 2613961 ccattgaaaa ttcacaaaaa cgagaatgag tccgccgata ataccgagca tccctggtcc 2614021 gactttatcg tataacagag cgctcaaaat ggccgcgatc gccactccga ttaaaagagt 2614081 caagcttaaa agaatgagat gctcctgaga aatatcatac atttgacgga gcaagccttg 2614141 aaaagcagaa aggctgacag ctaccgttat cgtccctgca gctatgatca ataagccgag 2614201 caccggtttt ggcagcagca tcagtttaat agatatgaag gggtttttca ctttatattc 2614261 cacaatcaat agaccaatga gcaaacataa cgtcaccccg aaaccaatcc atacataacc 2614321 cgatgacagc ccccattttt gcagaaaaat gaatgaaacc gctgaggctg cggcaaggaa 2614381 gacagataaa agaattcccg cacgatcaag cggctgttct tgatccgccg ctccgtgatg 2614441 ctcatcatga agaaagaaat agctcaccgc gacaccgatc agggacaagg tgccaaagat 2614501 gaaaaacagc catctccaat gcccgcagct tgttgcaatg gttcccagga ttgtaccgat 2614561 gataacagaa ccatagaatc ccccgatcag cacaagcagt gcatagttcc tgcgttcaat 2614621 cgggaatgac agtacaagca ttggaatcat aatcatcagc atgacgcctg ttgccgcccc 2614681 ttgtaaaaag cgccctgccg ccatcaatgc aatatcgcct gaacatgcga tgagcagtga 2614741 gcctagtata aagacaggta atgaagccag atagacggga cgagcaccga attttttcct 2614801 cagcagcggt cctgccggaa ctaacaaggc aaaggccata ttgccgatca atatcggatt 2614861 tactgatgta aagacacttg ttccaaccgt tttctgaaca aggccttgaa ctgacgacaa 2614921 tgccgtgtta gacatcaatc ccggcccgac cgctaagacg gcgagcaaag aaatcaccca 2614981 atagtgtttt gtcttcatgt tgtcatccct tcctatatga atacatgcga aacacatcat 2615041 tttttgaaaa caaaagaagc taatagattt tgcataccat tagctttcat tctaatattc 2615101 tccctttcag gggaaatgat attattttat tataattatg tgaatgaatg agcatataat 2615161 caaatattat ttcaaatcga ttgtgttttg tcaatggagt aaatttcaag cacaacatag 2615221 aaagcttgaa agcttttccc cgatattgtg tctagaactg cacttatgaa tccctgctcg 2615281 ttccctcaag cgaattaaag caggccgttt taatcctttc aatccactat tccaactaat 2615341 aaactcaaat aagttggtga taagacaaca ttttaccccc acattttttt gtgttcactg 2615401 ggcgtttgcc gcctctaaat tgtatatggg taaataccat gaattaacct atgaaatacc 2615461 aatgtaaggg aggcaaaaac gaatggaact gtatgagtgt atccaagaca tttttggcgg 2615521 cttgaaaaat ccatcggtta aagatttagc aacgtcttta aaacaaattc caaacgcagc 2615581 aaaattgagt caaccgtata ttaaggaacc agaccagtac gcttacggcc gaaatgccat 2615641 ctatcgaaat aatgaattgg aaattatcgt gattaacatt ccgccaaaca aggagacaac 2615701 agtacacgat catggtcaat ccattggttg tgcaatggtg ttagaaggaa agcttcttaa 2615761 ttctatttat cgttcaaccg gcgaacacgc agaactctcc aattcatact ttgtccacga 2615821 aggagaatgc cttatttcaa ccaaaggttt aattcacaaa atgtccaatc caacatctga 2615881 acgaatggtg tctcttcatg tctactcccc tcctttggaa gacatgacgg tctttgagga 2615941 acaaaaggag gtattggaaa attcatgatt gacagataaa ctgctcactt tgacttcact 2616001 caactggagg attcagagaa tgaaaccttt tcctcaaaac aaaaaaaccc ttatcgaata 2616061 agggtttaaa ggtatggagc caagggggct cgaacccctg acctctacgc tgccagcgta 2616121 gcgctctccc agctgagcta tggccccgta tgtaacgtca tgtttattat agatgatttt 2616181 attttgaaaa acaagctgtt tcctcttgaa ttgacagaaa aaataaggct cggaaaagag 2616241 ccttattttt cgacttacat catgatcaaa agtaaaatca caccgagaat aattcgatag 2616301 attgcaaatg ggacaagttt gattttgtta atcagcctta agaagaaacg gacgacaaac 2616361 agtgcgacca caaaggcaca gataaagccg acgatgaaaa acggcatcag atccgaactt 2616421 aagctgtccc aatgcttcac gaggcttaga aagctggctc ccatcatgat cggcatcgcc 2616481 ataataaacg taaagtcggc tgcagctcgg tggtttaatc cgagaataac accgccggaa 2616541 atggttgaac ccgaacgcga gaaaccaggc caaagggaaa gacattggaa taagccgacg 2616601 gctatcgcct gtttatagga aatgcggtcg agtgtgtctg tcgctgtttt ccgtttattg 2616661 acccagtcag caaaaagcat gaggattgcc ccggcaatta aaccgatggc cacagtttta 2616721 acggaaaata aatattcatc aatgtaatct tcaaacaaaa agccgagaac agctgcaggc 2616781 acgagtccga cggcaatttg ggcaatgctt aatttatgtc cctgctcctg gtcgcttgta 2616841 atattttttt tcaagcccag taaatttaaa attcggtctt taaacacgat agctactgct 2616901 aaaatggagc ctagctgaat aaccaccttg aatgagttag cagcttcttc tgacatcaga 2616961 ttacttgatt ttagccagat gtcgtctact atgatcatat gtcctgtcga agaaaccggc 2617021 gcgtactctg ttaatccttc tacgattcct aaaatggcgg ctacaaacaa ttcccataga 2617081 gtcatgattt tgattctccc cattagacat ttattttttt acataacggg agcttcccat 2617141 aaatggaaag cccgtcttat ataactataa acgaaaatca cactttatgc cccggcgtat 2617201 tttcattttt ttcttcatcg tataaatgtg actgcatttt aaaccagtca aataaatgtg 2617261 tcgtaatgac tttggcaacc gcatagccgg gaatcgcaag aatgattcca acaacgccaa 2617321 acagcttgcc ggctgttaac agcagaaaaa taatcgtaat cggatggatg tgaaggtttt 2617381 ttcccataat ttgcggagag atcagcttcc cttcaatcag ctgaacaatc gtccaaacga 2617441 tcaccagctt aagcagcatg agcggcgatg tcactatggc aatgataatc gcaggcgtaa 2617501 tggcaatcgt tggccctaaa tatggaacga tgcttgtgca agccgcaatg actgcaagca 2617561 atgaagcata atccagcccg ataatcaaat aaccgataaa cagcaaaaac ccgatacaga 2617621 agctgacaat gatctggcct ctgatataag agcttaaccg atgattcatt tcgcttaaga 2617681 ctgtatatgt ctgttctttc aatcgagtcg gcacaaactt cagtatgtag accggtaatt 2617741 ttcttccgtc ttttagcaaa taaaatagaa taaacggaac cgtgacgatc gaaatgataa 2617801 tctcagtcag tgcgccgata aaattcccaa caccggtaaa ggtgctgttc acgatcgtcg 2617861 ctgcctgatc cgaaaccttt gtagcaagat cagatatatt aatgttcatc gtttgctggg 2617921 cctgattgac gaagttgctg ccaatcagct gtttcgtctg attttctacg acgtccacat 2617981 atctcgggat attgtcaatc aaactcataa tttgttcttt taagaaggga atgatcgaca 2618041 cgatcgtgat cgtgatcagc ccgataacca ataggtatag cagcaatata gaatagattc 2618101 ttcttattct tcttctctcc agaaaatcga cgactgggtt taacagataa aaaacaatgc 2618161 ctgtcaaaat aatcggaagt gatatcgttt tgagcagaac aataatcggg gtgaaaataa 2618221 atgatgtttt tgtaaatact agaatattta aaccaatcag cagcagcaca agcaaaaata 2618281 aaacaaactt attatccaag aagaatcgct tgaatctgcc gctccatgtt tgcaacgtct 2618341 ccactatcgt tcctccgtca tacatagttt aattaaattg tacactatcg tccctataat 2618401 gaaaaataaa aaccgttaat tgctggaaaa gctttctcgg ttttaacatt ctatttatat 2618461 ctatcatgtg attttgttct ttttaagcta taatttagct atatcatgca aaaggagcga 2618521 tacgagtgat acgttttgca ataataggaa ccaactggat tacagaccgc tttcttgagt 2618581 cagcagcgga tatcgaagat tttcagctga ctgctgttta ttcaagatcg gctgaacgcg 2618641 ctggcgagtt tgctgctaaa cacaacgctg cgcatgcctt ctcagacctt caggaaatgg 2618701 cggcgagcga ttgctttgat gccgtataca tagcgagccc gaacgctctt cacaaggaac 2618761 aagccgttct ctttatgaac catggcaagc atgtgctttg tgagaagccg tttgcttcga 2618821 atacaaaaga aacagaagag atgatctcag cggctaaggc aaacggcgtt gttctcatgg 2618881 aagcaatgaa gaccactttc ctgccgaatt tcaaagaact gaaaaaacac ctgcataaaa 2618941 tcggcactgt ccgcagattt accgcaagct actgccagta ttcctcacga tatgacgcgt 2619001 tcagaagcgg aactgttttg aatgcgtttc agcctgagct ttccaatggg tcattaatgg 2619061 atattggcgt ctattgtatt tatccggctg ttgtgttgtt tggcgcgccg aaggatgtaa 2619121 aagcaaacgg atatgcttta tcctccggag tggacggaga aggaactgtc attctgtctt 2619181 acgacgggtt cgaagctgtt ctgatgcatt ccaaaatctc tacttcctat gccccggctg 2619241 aaatccaggg tgaagacggg acgattgtaa tcgatacgat tcaccggcct gaacgtgttg 2619301 aaatccgcta ccgggacggc cgccttgaaa acatcgcgat ccctgatcct aaaccggcga 2619361 tgttctatga agcagaagaa tttgtcacgc ttataaaaga gaataagctg gaatctgaag 2619421 aaaatacatt tgaacggtct ttgaccaccg caaaaattat ggaagaagca agaaagcaaa 2619481 tggggattgt ataccctgct gatcaagctt aaaaaaatcc gcccgcgtgc aaatgccgcg 2619541 gcggattttt tattagacaa tcggagaaga tgccttcctt tttaaaagca cctgttgctc 2619601 atattctttg atgtcataaa gccatgcctc ttttaccgga acgcccattt gctcacagta 2619661 ggaatcccag atggctccga aaggatatgt tttgaattcc tccatcaggg ccagcctttc 2619721 tgtatagcgg ccctcttcct gcaattgttt taaatatccg ttcgggagaa gcagggcata 2619781 caataaagct ttgatcatat ttctcgttcc gatggtccag gcggctacac ggttaatgct 2619841 ggcatcgaaa aaatccagac cgatggctac cttctcaaga gcatgatttc gtacaatttc 2619901 aagagcgatt tctctcaatt catcatccaa aaccactaca tggtcgctat cccaacgaac 2619961 aggccgcgat acgtgcaagg caagcttgtc tgtgtaaagc agcatggacg agatcttgtt 2620021 tgataccgtc tcagtcggat ggaaatggcc tgtatcaagt aaacaaagct tatgattcgt 2620081 caaagcataa gctaaataaa attcatgaga tccgacaaca tatgattcgg agccaagccc 2620141 gaacagcttg ctctcgattg aatcaagatt atgttgttca ctgatctcct ctgagaagat 2620201 ccgatccagt gattctttta gtcttttacg cggtgtcagc ctatcactcg ggatatcctt 2620261 atagccgtcg ggaatccaaa tattcgtcaa gcaaggtgtt cctaattctt tcccgaagta 2620321 ttccccgata cggcggcaag cgatgcaatg cctgatccaa aattctctga tgtccggatc 2620381 agggtgtgaa agggtgagtc cgtcagccgc tttctcatgc gaaaacaagg ttggattaaa 2620441 atctaaaccg agaccaaggt tttttgccca tttcacccag ttttcaaaat gctgcggctt 2620501 caattcgtca cgttctaccg cttccctgtt tgtttctgcg tatatcgcat gcaggtttac 2620561 gcggtgcttt ccaggaatga gagaaagagc cttctccaaa tctcttctta attcttcagg 2620621 agtttgcgct tttccgggat aattgccggt cacgtcaatt ccgcctgaaa gctcgccctt 2620681 atttacttca aagccttcaa tgtcgtcacc ctgccagcag tggatcgaaa tgggcacttg 2620741 ctctaattgc cgaagcgcct cttcaacatc aattccccat ttttcatatg cctgttttgc 2620801 actgtcataa ttggctttta tggtcatacg gctctctccc tttatcagtt tttcaatcca 2620861 aataaaaaac ttcctttaga tctatcgcaa caggactgaa atccgaattt gttttcatta 2620921 atggcgccat cgatttccac catctttggc aaacttccgt gtccgccatc tttctccatt 2620981 tctcttcatc ctctatttct aaatatgcaa aaagcctgcc tgtttcctcg tctagaaaaa 2621041 tggaataatg gtgtgctcca tgagctttga gtgcttctgc catctcaggc caaatgtcat 2621101 catgccgctg tttgtattct tcgtacttgt cttgatggac aaacatgata ctggcttttc 2621161 ttttcaaacc ttttcacctc ttcatcattt agatagcgct ttcaaaacag tttgctgaaa 2621221 tgactgaatg atcgtgcttc tatcaatgtc tttaggtgta aacactttga tcggaaagga 2621281 atttctgacg acttgccggg cttcttttat gtctttgact tctttggcag caatcatttg 2621341 catcaaaaga tttccggtgg cagttgcctc tatcggccct gcatataccg cttttccact 2621401 catgtctgcc gttaattgat ttaagaaatc attccgggct ccgccgccga tgatatgaaa 2621461 ttgctcgatc ggtttttctg tgattgtttc gagctctttg atggctatcg catagatgat 2621521 ggctaaattg ctgtagatgc agcaggcaag ttcgcctgca gtacggggaa tcttttggcg 2621581 ggtttgtctg caataatgtt gtatttcctt tatcatgttt tctggattca ggaaacgttt 2621641 atcatttaag tttataaatt gctggaatgg ttctgttttt ttggcttctt ctgcaagctg 2621701 ctgaaaagaa taatctgctt gtagctgctg tttgacttct tgtatcaccc acatgccgat 2621761 aatgtttttg agaaagcgaa tggtgttgtt tgcgccgcgt tcatttgtat agttgttttc 2621821 taaagcaaga tcagttatta tcggtgtttt gttttcaacc ccgattaacg accatgttcc 2621881 gctgctgata tacgcccagc catcatttac gcctggcgcc gcaatgacgg ccgaggccgt 2621941 atcatgtgtt gcgactgtca tcaccttgca cgccgggaga tcataatccg ggaaccactc 2622001 atttcttagc ttcccgagtt cacaccccgg ttcagtgagc ggcgcaaatt gctgttccag 2622061 aacagacacg gcttcaagca attcaggatc aagatttccc gttgagacgt ttaaaagctg 2622121 tgttgtggac acgtttgtga tttccgttac agcttttccg gttaaacaat agcctaaata 2622181 atcaggaatc atcataattt tgtctgtctt tttcagcagc tcacggtctt cttcaaacaa 2622241 ttgatagatc gtgttgaaag gctgaaattg tattcctgtt ttttgataaa ttgcggcttt 2622301 tgagagggta tgttccagtt tgtctattgt gtgatctgtt cttctatcac ggtaggagat 2622361 tgcttcccgc aaccgatcgc ctttttcgtc cagtaagaca taatcgactg cccatgtatc 2622421 aatgcctacg gtgcagtgtt catacccaag cgtctttact ttttgcagtc cttgcaggat 2622481 ttgttttagc aaatgatcaa tatcccataa gcaatgcccg tctctttgac tgaaaccgtt 2622541 agcgaacctg tgaatctctt gtatgtcaag cttcccttca ttcagttcac ctaccatgat 2622601 tctcccgctt gatgcgccta catcaatggc agtataaatc atcctttcac cctctcttcg 2622661 aaagaggaac agctgtcacc ttcacctttt tgtcctcaag agcttttacc gatgccggat 2622721 caagtccaga atccgtaata aggcggctga catcttgcag cgaggcgata tgtgaaaact 2622781 cgcggttccc ccatttgctt gaatcggcca tcaaaatggt ctggtccgac ctttcgatca 2622841 tccgtttttt gagcagcgcc tgccactcat ttgaatcact catcccgttg tgtacgtcaa 2622901 atcccttaca tgacagaaag gttttattga catgataggt ctcaagtgaa cgctctgcta 2622961 acgggccggc aaatgataat gatttttcca gcaaaatgcc gcctgttgaa atgactgata 2623021 tgttttcttt attgctgagt tcaatagctg ctttcattga gtttgtaatc acggtgagct 2623081 caatgtcagg gagtattttt gccatgtacc aagcggttgt gcttgcatcg agaatgattc 2623141 ggtctccgct ttttacatat ttggccgctt cgtgagcgat ggcttttttt tcgatgacat 2623201 tcgtgatttc ccgttcagaa aaatgaattt ctgattcctt ctgctgaata ctgaccgctc 2623261 ctccgtggct ccggctcagt ttatgttctt tttcaagctt ttcaagatca cgccgaatgg 2623321 tttcctctgt gactgaaaaa atgtcactta attcggaaac gcggatgctt gaacgcatat 2623381 ttactatttc cactattttt tgctgccgtt ctgctactag catcggtaac gcccttcctc 2623441 atatcgtagt ccgtcttata tttttatcat agcatatatc taacgcgtaa aagcagcagg 2623501 gacgccgccg tctaccgtga tcatgcagcc cgttgttttt tcggctttgg aagaagcgaa 2623561 gaatgcaatg gcttcggcaa tatcctccgg gtaaatattg acgagcaatg ctgtccgttt 2623621 ccggtaatgt tcctccagct gatccggttc aatcccgtac gccgcggctc gttcctcacg 2623681 ccagcttgaa ccccagattg ccgatccttg aagaactgca tcaggcaaaa cggagttgac 2623741 cctaatgccg aattctccgc cttctgctgc gatgcatctt gctaaatggg tttcaagcgc 2623801 cttaacagag ctgtaggcag aggcgttttt tcccgcataa actgaatttt tcgatccgac 2623861 aaataccatg cttccgcctc tattttgatg tttcatctgt ttaaacgctt cacgggctac 2623921 aaggaaatag cctgttccta aaacattcat attaagattc cattctttta gacttgtttc 2623981 gtcaaatggg cttgatgtgg ccagcccggc attattgacg acgatatcaa tgccgccgta 2624041 agcaagcgcc gctcgttcaa aagctgactg tacgtcttcc tcctttgtca catccatttt 2624101 gacagccatt gcccgtcctt ttccgtatgc atcgtttatt tccccggcaa ttttctgtgc 2624161 gccttctata ttcagatcag ctacgatcac gtgccctccc tcagctgcaa atcggcggca 2624221 tgccgcactg ccgattccgc cggctcctcc agttatcagc gctacttttc gggaaaattc 2624281 tgcttccggc ggggccagcg tgagtttata tagttcgagc ggccaatatt cgacatggta 2624341 ggactcattt tcatgtaaag aaacaaattg ccccagagcg gttgctcctt tcattacggc 2624401 gatggccctc cgatataaag ccccgcttac tttagacatc gcataacttt ttcctgtatt 2624461 caccattccg attccaggaa tcaatatcac ccgcggggcg gattcaaaga tttgatcccc 2624521 atcctgctga ttgcgtgtaa agtaagcctg atactctgat gtaaaggtct cgactcctga 2624581 cttgatcaga tctgcaagct tgtgcacatc ttgagtttcc ggattccaat caatgtacag 2624641 cggaacccgt tttgtgtgaa caaggtgatc cgggcatgcc gcaccgattt gcgaaagtgc 2624701 tggcgcttgg acactgttta caaattccaa gacatcgtca tgatcatcat aggaaaggat 2624761 cattttcttt tcttcactta ctgctcctct gatcacaggc atgatgcctg ccaagatttg 2624821 ttttctttta tcctccggca gcggctgata ccttttgcct ccgaatacct catgctgatt 2624881 gatacgatcg ttaatatact gctcggcttc ttgaatgatg gatatcgttt tttgataaca 2624941 tgtttcagac gtctctcccc aagtgactaa gccgtgtttc tccattaata caagctcggc 2625001 gtgggggttg tttgctacgc cttcagcgat cattttagac aaagtaaatc caggacggac 2625061 gtatggcacc catacaaacc gatttccgta aatgtcttca gcgatttgtt ttccattatc 2625121 cgcacagcat atgctgataa tcgcatctgg atgggtatgg tcaacatgtt tgtatggcag 2625181 aaaagcgtgt aatagcgttt caattgaagg gcggggatgt ttgctgtcta tcatacaatg 2625241 agacaggtag tctaccattt cttcatcggg catttggtcc cttttaatca gcgggcggat 2625301 atcatctaat ttcaaaccgg aaaagttatg cgctttcatt gttgccaaat ccgatccgct 2625361 tccttttacc cacatgactt ctatttcacg gcctctaaaa tccttttccg ttgttttcat 2625421 agatgtattc cccccgcccc agttgcagac agtgcggtct gacccgatca gattggacct 2625481 gtacaccaat tcctctacac ctttaggtag ctgtgcagct cgctctgaat cccatatatg 2625541 tttcaccata tttgatattc ctccataccc ttttatttgt atccgttttc attatatatg 2625601 atttctgttt gtttttgaat cgtttttgtt tatttttgct ttttaacaaa aaaagaaagc 2625661 agcagatatg ccgctttctc gtttcattat gattctattt taaatttctt cgtaatgtcc 2625721 tgaagttctt ccgccatgtt tgccaacgtt tccgctgaag agctgatttc ttccatggac 2625781 gcaagctgtt cttccgccga agctgcgata tcctgaatgc ctgctgagct ttctttcgcc 2625841 actgcagaaa tatcttcaac agcacttgac acttcctgtg atccggctga cagttgttca 2625901 accgtcgcgt tcaagttttg caattcgccg gaaatttggg ttgtcatctc atagatttgt 2625961 ttaaagcttt ccgctgtttg atccgtaatc tgcaagcctt ctttcacttc atgattcacg 2626021 gattggaaca ttgaaagtga ggtgctgatt tccctgacaa tctcttgaat taatccttca 2626081 atttccttgg cggagtctgc tgattgtaca gcaagttttc taacctcttc cgcaactact 2626141 gagaaacctc ttccgtattc tcccgctctt gccgcctcaa tcgcagcatt taatgcaagc 2626201 aggttggttt gatcagcaat gccgttaatc acattcaaga tgcttgtgat gtcttgcgat 2626261 tttgtttcaa ggcccttcac aaccgcttcc gctttttgaa cggattggtc aattgttttc 2626321 atctggccga ctgtatgctc caccagcttt tctccgctgc ccgctgcctc agaggactga 2626381 atcgatgatt tcgtaatggt tgaagaggct tgagccactt ttgaaatccc ctcgttcatt 2626441 tgagaaagat gatttgagct tgtttccagt ttctcgcttt gtgcctcgtt gccatctgag 2626501 aactgttcga tggcaagtgt aatatgttca gttgccttgc ttgtttgggc tgcgcttgct 2626561 gtcagctcct cagaagatga agcgacgttt tctacagacg tttgaataac gcctattaca 2626621 gaacgcaatg atgcagacat ttcattaaag ctttcgccaa gctggccaaa ctcgtttttc 2626681 gagtgaatgt caatgacttc tgtgagatct ccgctgctga tttttgcaga cgttgagaca 2626741 agttttctta acggcttggt gatggcacgg ataatataga gtatgagtat gccgccgatt 2626801 actattgaca cgcatagaat gataaccgca gtgttcagca ccgggcttga agcatcttgc 2626861 aattcactga caaaatatgt gcccgcgatt ttccagccag tcagtttatt tgtcgtaaag 2626921 gccattttct tttctttgcc ttcgaatgta tattcaaatg agccttcttt tttggaatat 2626981 acttggtttg tccaatcgcc ggaaccggtt gtccccggct taatggtcgg atgggcgata 2627041 tattttttgt tgcctgtcgt aataaatgca aagccttctt ttccgatttt gattcttttt 2627101 gatgcagtaa gcacttcatc caggtttaaa tctagcgcta taacccctga accgtctttt 2627161 aattgttttg aaattgtgac aacgatatct cctgtcgctt catcggtata cggttctgag 2627221 aaaacagctt gtcctttttc cgcaaccgcc tgtttgtacc agtcacgtcc tgtcggatcg 2627281 aaacctttcg gaacaccgct atccggatat ttataaagct tcttatcttc tgaggcagca 2627341 tagattgcgc ctacatcgtc gttaagtgtc gtgtactgct taaatttctc tttcagtaat 2627401 gttttgtttt tgcctaacaa tatgtcttta tcgactgtct cactataata atctattgct 2627461 tttactttat cttctaattt attttgcagc gtactgttta gttcttcaac atttcccttc 2627521 gcactgctta tgagctctct gtctaacgcg ttccaagctg attgataact gaaatatgct 2627581 aaaaccccaa ccggcaaaat aagcactgcc agaaacgcag cgattagcgg tttgctgatc 2627641 gatggctgtt tgatccattg tatgaatttt cccattctcg ttgactcctc ctttaagata 2627701 aatctaatat cgtcaaacta ggataaaagg tttaataaaa aaactaaaaa aaacacccaa 2627761 gcgcaacaag cttgggtgtt aaggcttatt attcaatttt aaatcgtttg gtcatatccc 2627821 gaagctcttc cgccatagag gaaagggtct ctgcagacga gctgatttct tccatggaag 2627881 ctagctgctc ttcagctgac gccgcgatat cttgtatatg cgctgagctt tcttttgaaa 2627941 tcgatgcaat gtgctcagac gctcccgaaa cttcttcgga gctggcagaa agctgctgaa 2628001 ccgtcgcact catattttgc agttcgccgg cgatttggtt cgtcatttca gaaatgcgtt 2628061 tgaagctcat ttctgtttta tctgtgatgt caagtcctgt ctgcacctct tgattgacag 2628121 attggaacat gccgagtgat gtattgattt ccttcacaat ttcgatgatt aatccttcaa 2628181 tctcttttgc tgaatctgct gactgtactg ccagttttct tacttcttcc gctacaacgg 2628241 agaagccgcg gccgtactcg cctgcgcgcg ctgcttcaat tgctgcgttt aaggcaagca 2628301 ggttcgtctg gtctgcgatg ccgttgatca cacgcaaaat gtttgtaata tctttcgatt 2628361 tcgtttccaa tccgcgtacg acttgctccg cttctttaac ggacttgtca atgacattca 2628421 tttggccgac ggtttgatga acaagcttgc cgccttcact tgcaatttct gtcgattgaa 2628481 cagatgaatc agtgatcact tcagaagctt gagccatatt cgtcaacccg tcattcattt 2628541 gataaatgtg ctctgctgcc gtttcaatgt tttcgttttg tttttcattg ccgttagaaa 2628601 attgttcaat cgccaatgta atgtgctctg ttgccttgct cgtttgcgca gctgatgcag 2628661 tcagctcctc agaggaagcg gcaacattgt ctaccgaatc ctggatggcg tgtatgagag 2628721 aacgaagtga cgacgccata ttgttaaagc ttttgccgag ctcgcccaat tcatcttttg 2628781 aacggatatc aatggtttcc gtcaaatctc cctcgctgat ccgcttagag gaaccgacaa 2628841 gctgtttcag cggtgttgta atcgaccgaa tgatcaatgt catgacgata atccctatga 2628901 taatagctgc ggccaagaca attaaagcaa ggtgaaggac aggctgggct gcctcatgga 2628961 tttcatccaa atacatggtg ccgccgatct tccatcccgt caacttgttt gtgtcaaagg 2629021 ccattttttt cttatcgcca tccatggtgt attgaaaatc gcctttatca gcactcaaca 2629081 tcttatcgag ccagtcgcct tttaattcag ttcctgattg ttcattaggg tgtgcgacaa 2629141 cttttttgtc cttcgtcatg ataaatgcgt agccttgtgt gccgatgttg acttttttgg 2629201 ttgttttcag cagattttca atcgtcatgt tgattgcgat aacgcctgaa ccatcttttg 2629261 tctgctgggc gattgtcaca accatcgtat ttgtcgacgc ggttttataa gggtctgtga 2629321 tcacgacttt ccctttattt gcaaccgctt ttttgtacca gtcgcgttca accggattat 2629381 agccgcttgg catcggaaga tccggatagc gggtaaagtg cccttttgtg tcacttgtat 2629441 aaatggattc tacatccttg ttaatgctga tatattgtga gaatttctct gcaatgcttg 2629501 cattgctttt tgcattgtat ttctcttttg tcagccattc gctgaaataa tcagcactgt 2629561 tttctttttc gccgatgctg gtgttaatga tttcgtttaa ttgctgtaca ttttccaatg 2629621 cgctccccat catctgtctg tcgagtgagc tgctagccga ttgatacgca aagatcgcca 2629681 atatgacaac cggtatgatg aggatcgaca gaaaggaaac gagaagcttc cgtgtaattg 2629741 atctttgttt tatgagttgg agtatttttt tcatcattca tttctccttt tttatgctac 2629801 ccttcatatc ggctggaaat gggtaaatat atacagcaaa aaagaagaaa tttaacaaaa 2629861 gtaactaatt tcccataaat aaatagtatt ttagacctat tatttgtcta ctttaaattg 2629921 ttttgtcaga tcacggagtt cttcagacat tctttcaagc gtcagtgcag atgaactaat 2629981 ctcctccatg gatgccagct gttcctcagc tgaagcggcg atatcttgga tgccatccga 2630041 gctttcctta gaaatggcag tgatatcatt tgaagctgcg gaaatttctt gagctcccgc 2630101 tgacagctcc tcaaccgtcg cattcatgtt ttgcagctcg gaagcaattt gattggtcat 2630161 ttgcgatata tgtttgaagc tctgtttagt ttcatccgtc atgacaagcc ctgtttcaac 2630221 ttctttgttt acggactgaa gcacgttcag tgatgtgtga atttctttta ctatttcact 2630281 gatcagcgat tcaatttctt ttgctgagtc agccgactgt accgcgagct ttctcacttc 2630341 ctcagcgacg actgagaagc cccggccgta ttcacccgct ctggcagctt caatggcggc 2630401 atttaaagcc aaaagattgg tttgatccgc aatgccgttg atgacacgca aaatattcgt 2630461 gatatccttt gatttgatct ccagcccttt caccacttgt tccgctgctt ttacggaatg 2630521 gtcaattgtg ttcatttggc cggctgtttt ctggacgagt gtctcccctt tgcttgacac 2630581 ttcggttgaa tctgcggatg tttctgtaat cactgctgca gcccgcgcca gctctgccaa 2630641 tccgtcattc atttcattaa tttgttcggt tgtcgtttct attttctcgc tttggctttc 2630701 actgccgttt gaaaattgct cgatagccat cgtaatgtgc tcagtggctc tgcttgtctg 2630761 gtctgccgat gcagtcagct cttcagacga ggaggcaacg tgttctactg agtctttgat 2630821 cccgtgaatg agcgagcgaa gcgagtgtgc catatgattg aagctctcac tcagaacgcc 2630881 gagttcatct tttgaattga tttcaatcgt ttcggttaga tcgccttcac taattttttc 2630941 agcggatgcg acaatgcgtc tcaatggctt tgtgatggat cgaatcacaa aataaatcgc 2631001 cgtcattcca gctccgatgg caatcgccag aacgattgaa gccatgatca gaaccctgct 2631061 tgcagcatcg tgaatctcgt ttgcatacat cgtgccgctg attttccagc ctgttgtttg 2631121 gcttgttgca aatgccattt ttttcttttt gcctttgtac gtatattcaa agtccccgct 2631181 tttatccttg tagagcttat caacccagtc cccttttagc tctgttcccg ctttttctcc 2631241 ggagtaggcg atgactttct tgttttggct caaaataaaa gcatagcctt cttttccgat 2631301 attgattcct ttcgcggtag tgactaagtc atcaattttc atatcaatgg cgacaacgcc 2631361 tgacccatcc accgtttgac gggcgatggt gacgaccatt tttcctgatg aaatcgattc 2631421 ataaggctca gtgacaattg ttttgccttt attggccatt gcttctttgt accaatctcg 2631481 ttccaaagca ttaaagtcgc ttggcatgtc agcgtacgga taacgtgtga agtccccgtc 2631541 tttgccgctt gaaaataccg cagcgacatt atcattcatt tggataaatt gtttaaattc 2631601 ctgtttcagc tctgttttct ttttatcctg aaatttttct gctgtagccc aatcgctgaa 2631661 atatgcgagg cttttttcag tagtgctgat tttatcatca atgatgtgat ctaatatctg 2631721 aacattttcc tttgcgcttt gcgtcatctg tacatcaagt gaggcaactg ctgattgata 2631781 agcgctaacc gaaagggcgg ttatcggaac aattaagatc agcaggaaag aaataataag 2631841 tctccttgca attgatgatc tgcgaatagt ggtgagtgtt tttttcattt ccttttgaac 2631901 cttctttcaa taatttacaa attatatcgg cggatcttcc tttaaattac attgaaaatg 2631961 gaggaaaaaa tgaaaaatag ttctaaattc acctgttaaa ctaggacttt attattgttt 2632021 accatataaa aaaacagcgc tttgatagcg ctgtttttcg gtttttactc gattttaaat 2632081 tgtttcgtca gatcgcgaag ctcttctgcc atctgcgcaa gagtcgtcgc tgaggaactg 2632141 atttcttcca tggaagcaag ctgttcttca gctgatgcgg caatgtcctg gatgcttgcc 2632201 gagctttctt tcgacacgtc tgcaatgccg ctgactgctg ctgaaacatg ctgtgaacgg 2632261 tctgacagct gctcgacggt ggaattcatc gtctgcagct tgcccgcgat ttcgtttgtc 2632321 atgctgaaaa tgctctggaa gctttctttt gtattgtctg tgacaacaag tccggactgt 2632381 acttcctgat tgacctcttt aaacatgtga agagaggtgt cgatttctgc gacgatttct 2632441 tggatcagct tttcgatttc tttcgctgaa tcggctgatt ggacagccag cttgcgcacc 2632501 tcctccgcta cgacagagaa gccgcgtcct gactctccgg cacgcgccgc ttcaatggct 2632561 gcatttagtg caagcagatt tgtttggtca gcgattccgt tgatgactct caaaatgctt 2632621 gtgatgtctt ttgattttcc ttctaagcct ttgacaacag cttcagcctg ctgaacagat 2632681 tgattaatcg agttcatttg tccgactgtc tgctgcacaa acttctcacc cgttccggcg 2632741 atttccgttg attggataga tgcctttgta atatctgacg atgtttgtga gacttgctgg 2632801 agtccttcat tcattaagtt cagctgatga gagctggatt caaccttttc gctttgctcc 2632861 tcgtttccgt ttgagaactg ctcaatcgcc atcgtaatat gctcggtggc tttactcgtc 2632921 tgcccggcag atgcggtaag ctgttcggaa gatgcggcca cattgttcac cgagtcctga 2632981 atagcgctga tcagagagcg gagagattgt cccatttcat tgaagctttc cccaagctct 2633041 ccaagctcat cctttgaatg gatttcgatc gtttcggtca gatcccccct gctgatcgtt 2633101 ttcgatgatt gaacaagacg ttttaacggt tttgtaatcg aacgaacgat aaacagaatt 2633161 aaaattccgc ctgccacaat ggaagcaatc agcacaatca ttcctgttgt cagcacagac 2633221 tttgaggcat ccttaatttc atccatatac attgtgccgg ctattttcca accagtcagt 2633281 tcgtttgtag tataggtcat ctttttatct tcgttattaa gagtatactg gagttcaccg 2633341 ctgtcattcg catacatttt ggctacccag tcgcctgaaa gcttttctcc agccttatgg 2633401 ttcttgtggg cgacataggt tttgtttttt gttgcaatga aagcataacc ttcttttccg 2633461 accttgattt gtttcatttg ttctaacaat ttatcaatgg taatatccat ggcgacaacg 2633521 ccagatccgt ccttcagctc ctgtgcaatg gtaatgacca tgcttccgtc actcgcagcc 2633581 acgtaaggat ctgtcacgac aatttcaccg ccggccttca tcgcatcctg gtaccaaggc 2633641 cgttgtctcg ggtcgtatcc ttccggcaat ttttcttttg gcgcttgtac ataagtgccg 2633701 ttatctgcgc ccccataaat tctggctact ccttgattaa tagatacata ttgtgaaaat 2633761 ttagctttga tctcttcttg atttgatttc cctttgaatg cggatctttt aagagattca 2633821 ctgaaaaagg tgactgcttt cgctttttct cccagatcat ttgtaacagt tgtattaaat 2633881 gtatcgacac tgtttttcgc atttcccata atttcctgat ccagctttcc gctggcgctt 2633941 cggtaagagc taaattctaa tataagaata gggataatga gaatcgcaat aaatgagacg 2634001 attaatttct ttgaaataga cggtttcttc agccaattga taaaagtctt catgtcactt 2634061 gctccttcag gtttgataca gtatatatcg gctgcttaaa aaagttttaa aataaaaaat 2634121 ggaagaagtt ctttttggct gtcttctgcc tttttaactt tcattgccca agctctttgc 2634181 atatcttata aaaaacaagg ggggctaaac atgattattg tatcaggaca attgctccgt 2634241 ccccaggata ttgaaaattg gcagattgat caagatctga atccgctctt aaaagagatg 2634301 attgagacgc ctgttcagtt tgattatcat tcaattgctg aactgatgtt tgagcttaaa 2634361 ctgcggatga atattgtagc agcggcaaag acgctgcaca aaagcggggc gaagtttgcc 2634421 acttttttaa aaacatacgg gaatacaacg tattggaggg tttcaccgga gggcgccttg 2634481 gagctgaaat acagaatgcc gccttcaaaa gcgattcggg acattgcaga gaacggcccg 2634541 ttttatgcgt ttgaatgcgc aaccgcaatc gttatcattt attacttggc cttaatcgat 2634601 acaatcggag aagataaatt caatgccagc tttgacagaa ttattttata tgactggcat 2634661 tatgagaaat tgccgatata tacggaaaca ggacaccact ttttccttgg agattgtttg 2634721 tattttaaga atcctgaatt tgatccgcaa aaggcgcaat ggagaggcga aaatgtgata 2634781 ctactggggg aagataaata ttttgcccat ggtcttggaa tcttaaacgg aaagcaaatt 2634841 attgataagc tgaattcttt taggaaaaaa ggagccttac agtcagccta ccttctgtct 2634901 caggcgacca gactggatgt tccgtctctt ttccgcatcg tccgctaaaa agccccatcg 2634961 cctattttcc ggacgatggg gtttcaaatg cctttcgttt tcgatagaag ggggctgtgc 2635021 caaaatattg gttcgcagcc cactccattt tttcaaggtc atttcttgtc acgattggat 2635081 cctggctgct ccatttgata aagcggacaa aatagtagcc tttgatagga accattgtaa 2635141 cttttgagtg aggccagcct tcaaatacaa actcaatttt ccctcttttt ttataagaat 2635201 attgaagaat gttcatatct gtcacctcag tttatcaagt tacgttcggc aaagctcggt 2635261 acgtttacat ccattgatta actatccctc atgcaggctt tccggaaaac aaagggtgag 2635321 gcgcgtgtct ctttccctcg ctttttattt cgcatatgga cgaatgccaa gcacgccttc 2635381 attcgataaa gccgcagcgt gggcgggtgt gacaagccct ccggctatcg gcgcttgttc 2635441 agcgatcatg cttttgtcat aaaaaacagc ctattatccc atcattttga tatagcatgt 2635501 ccgggtgcga ggcccgtcaa attcgcagaa ataaatgccc tgccacgttc caagaataag 2635561 ccggccgttt tccacaatga catgctgtga agctccgacc gtactcgact tcatgtgtgc 2635621 agctgtattg ccctccatat ggcggtccag ctcatgttcc cacggatata cctcatcaaa 2635681 ccttctgagc atatcttttt tgacgtccgg atcggcattt tcattaattg taatgcccgc 2635741 agtcgtatgc ggacagtaaa tcagcgctgc gccgctcgtt atacctgttt cttgaagaaa 2635801 cgcttccacc tcccgggtga tatctatcat ttcatctcgt ttggttgttt tgatttgcag 2635861 tgttttcagc atttgtttct cctttcgttt gtccgctctc atcgcttaat tcgttctgtg 2635921 ttcttttttt tcctgttaaa ccgctctcat aaacccgata aaacaaaaaa actccagtct 2635981 aaggctggag tttagcacca tagatatatt cttgcttcat acggctttaa gagtactgat 2636041 gtcatatgct tgtgcggctc tgtttcaata tttgacaaga cgagtgcatc tgatgacaat 2636101 ggcaatccag agtgcctgaa caacgccggt gttcctgtca gattggccgc aatcagtgca 2636161 gtatggctct cgtttttccg aagatatgca aagatttgct gatcttccgg taaaatgagc 2636221 tcgtatgtcc cgttaataaa aacatcatat gtttggcgca gcttgatcaa gcttttgtaa 2636281 aaatggtaaa cggatgtttt atcgtttttt tgcgcctcgg cattcagcca tttgtaattc 2636341 tcattgattc cgatccacgg tttggcctca gaaaatccgg cgtatggacc agcattccat 2636401 tgcatcggcg ttcgcgaatt gtctcttccc tttttccaga caatcttcat cacatcctcg 2636461 tgtgatgtgc ctttcgctgt ttttgtttca tacaggcgtt tcaatgcgac atcatcatag 2636521 tcctcaatag atggaaaagc cacgttcgtc atcccgagtt cctgtccctg ataaataaac 2636581 ggtgtgcctt tcatgagaaa ataaacagcg gaaagcgctt ttgcactttc tttcaggtac 2636641 actccgtcgt ctccccacac agaaactgaa cggggctggt cgtgattctc cataaacaaa 2636701 gcattccagc cgatcccttc cagactgtcc tgccagtcag ttaaaattcg tttaaatgca 2636761 acgatatcaa tactttcatt gatctctaca tcccacaggc cgagatgctc aaattgaaaa 2636821 atcatgctga atatgccgtt tttttctcca gcccaatcag ctgcttcttt tgcagcgacg 2636881 ccgtttgctt caccaactgt cataatcgga tagcgggaaa atgtgttttc cttcagctct 2636941 gttaacaaat ccataatgcc gtcagcattc atatgataag gaaaggaagg gacatagtcc 2637001 agtccctttg gattcggcat gtcaggaaac ccttcttttt tcttaatatg cgtaatggca 2637061 tccacccgaa atccgtcaat tcctttatca agccaccaat tgatcatgtc ataaacggca 2637121 ttcctcacct tttcattttc ccaattcaaa tcaggctgtt ttttatcaaa aaggtgcaga 2637181 taatactggc ttgtcttttg atcatactcc caagccggcc cgccgaaaat gctttcccaa 2637241 ttgttgggcg tttttccgtt tttgccgtct ttccaaatat accagtcgcg cttttccgag 2637301 tgtatggatg aacgggattc tatgaaccat ggatgttcgt cgcttgtgtg gttcacaacg 2637361 agatccataa tcagcttcat atccagatca tgaatgtcac caagcagctc atcaaaatct 2637421 tccatcgtgc caaactcgct taatatgttt tgataatccc tgatatcata gccattatcg 2637481 gcattcggtg aatcatacag cgggcaaatc catatgacgt cagcgcccag ctcttttatg 2637541 taagaaagct tggttctgat tccttgaata tccccgattc cgtcgccatt tgaatcttta 2637601 aaactgcggg ggtaaatttg gtaaactacg gcttccttcc accaagcctt tttcatacag 2637661 ccactccttc ccagtgtacc gttcttatat atcctatgta gaaaaaggtc tttacagcat 2637721 tgctttttaa gaaatgactt gatgacacaa aaaacagccg tttgttcccc ggctgttttt 2637781 tatcaaaaat cagttttttt tatttctaca aaacggatgt ggtgatcttc ggcgtcgagg 2637841 attttaaatt cacagccctc cgcgtgtatc acatcccctg ctttcagctc cattttttgc 2637901 gttagaagcc agcctgcaat cgtatcaatt tcttcatttt caatcgcaat gtcgagaagg 2637961 tcattcactt cgtctattag cgcttttcca tccatcacat aatggtgctc gccctttttc 2638021 aggatgtgcg gtgtttcatc ctgatcatac tcatcgcgga tttccccgac gatttcctcg 2638081 ataatatcct ctacagtgac aagccccgcc gttcccccgt attcatcgac aagaatcgcc 2638141 atgtgaatcc gctccttctg catgcggatt aaaagctgct gaacaggaat gctttcaatg 2638201 actctgataa cgggcctcat gatttgattc agctttatcg gctggccgag aaaataagct 2638261 ttaaacatat ctttgctgtt gatgatccct aaaatatgat ccttgtcatc tttgatgaca 2638321 gggtagcgtg tataccgttc attaatgatg tgatgaattg cctcttcaag cgactgctcc 2638381 agagagataa ccgcaatttc tgtccgcgga atcataatct ctctcgctac ccggttgtca 2638441 aattcaaaaa tcttatttac atagcggaat tcagactgat tgatttctcc cttttcatag 2638501 ctttcagaaa ggatcagcct tagttcctct tcgctgatga caacctgatg ctcctttacc 2638561 gaatgaaagc caaacaattt cacaagaaaa cttgcagagc cgtttaatgc tttaataaac 2638621 gggtacgtga ttttataaaa ccagatcagc ggctttgcaa tccataagct tacagcttca 2638681 gctttttgaa tagaaaccgt tttcggggca agctccccca tcaccacatg caaaaaagtg 2638741 acgatgataa atgcaactac aaatgtgaca atgtggttaa acggttccgg tatgcctgtc 2638801 attgtaaata agggatgaag aaaacgttca aatgtaggtt caccaagcca cccaaggccg 2638861 agggctgtaa tcgtaatccc gagctggcag gctgataaat actcgtcaag attggagatg 2638921 attttatgtg cggctagtgc tcggctgtca ccgctttcga tgagctgatt gatttttgaa 2638981 cctctgattt tgacgatcgc aaattccgct gcaacgaaaa cagccgtaat gccaatcaaa 2639041 acaaaaatgg cgatcaattg taaaataagc aaaaaaagcc cttaccataa atggtaaggg 2639101 gccacctcct taacgttaat tctcatcacg accgtttaag aaaatcatca caaaacgaag 2639161 tagttcaaac agggaaacca gggcggcggc cacatacgtt aaggcagcag cactcagcac 2639221 tttatttacc ccattttctt cattgtttcg gatgaatcct tctgacacaa taatctgctt 2639281 cgcacgtgaa cttgcattga attcgacagg caatgtaatc agctggaaaa agacagccgc 2639341 tgaaaacagt atgatgccaa gcccgatcaa attcaggctg ccgagaagca tgcctcctaa 2639401 gaaaagcaaa ggagctacac cggatgcaaa attcacgact gggaagattt tatgtctcag 2639461 cacaagcgca ccatatgact cctgatgctg caaggcatgt ccgacttcat gggaagctac 2639521 ggatatggcg gaaattgagc ggccgtaata gaccggctca gataaacgca ccacccgtct 2639581 tgtcgggtcg taatggtctg ttaaagtgcc tcttaccggt tcgaccggca cgtcgtaaag 2639641 accgtttata tctaaaatcc gtcttgccgt ttctgcccct gtacgtccgc ttgaggcttc 2639701 cacttttgaa tatttttcaa agttgctctt tactttaaat tgtgcccaaa acgacaatcc 2639761 caatgcggct attgttaaaa atataaacag cattttttca tcatcctttg ttcatgatca 2639821 tttctctatt acgattattt taatgagttt tctttctcgt gtacagaaat gcgctttttc 2639881 ttccggcttg gagcacacaa tccaatcagc aaaaagaaca ggcctgctga aaacaaataa 2639941 aaggcgaaac tgccggccag ttctttcaga aaatgaagcc aggagaagct tccggaaaag 2640001 tgattatatg aattcaaatc gaaaataaac aaaatcaccg cggatgccgc cagctgcgta 2640061 ccgattaaaa ccacgatcgt tctttgaaag atcgtcatct ttttcatcct ttttgtttta 2640121 gtttatggag aaatccggtt ttatatgttt tgtacatttt ttgaaaaaca tcaccggaag 2640181 tgggacatac tgttagaaaa aagcacgggt gtgatggaag ctatgaaagt gacgagtgag 2640241 gaaaaggaac agctgagcac agcaatcgac cgaatgaatg aaggactgga cgcgtttatc 2640301 cagctgtata atgaatcgga aattgatgaa ccgcttattc agcttgatga tgatacagcc 2640361 gagttaatga agcaggcccg agatatgtac ggccaggaaa agctaaatga gaaattaaat 2640421 acaattatta aacagatttt atccatctca gtatctgaag aaggagaaaa agaatgaaat 2640481 caaatcggat atttatttca tggctcaggt ggccgttatt tatccgaatc ggggttatta 2640541 ttttatgtct gattcttttg ttcggccaaa tcatttatat acttgagcct aagcagttca 2640601 cttcggtatt cgaaggtatt tggtgggctg tcgttacggt ttctacagtc ggttatggag 2640661 actatgtgcc gcacactccg ctgggacagg cagccggaat actgctgatt ttgagcggag 2640721 caagctttgt cacagcgtat ttcgctacgt tatcagcggc cgcattcagc agacagcatc 2640781 gctacattga aggaaaagtt gcttacaaag gccgggacca catcattctg atcgggtgga 2640841 atgaaaaaac aaaccggctt ttgaaggacc ttcagcttgc cgccccttcc aaaacagtcg 2640901 tactaatcga tgaatcctta acagaaggcc cgcttattga aaacgttcat ttcatacgcg 2640961 ggcacgctgc cgatgatggg acactgaaac gggccaatat tactgaagcg gaatcagtga 2641021 tgattactgc cgatcagtat aaaagtgaaa ctgatgctga tatgctgtca gtgctgactc 2641081 ttttatctgt taaaggtctt aatccccttg cttactgcat cgtcgagatt ttaactgacc 2641141 gttttgtcac caatgcggaa cgggcaggcg caaaccaaat catcggaact tcagaattta 2641201 tcagccgggc gatgctgcag cattaccaag tcaagttacg gccgtctaaa cagcagaacg 2641261 gaatcaagct gacacttgat cagcatgtgg agcttcttgc tgttcctgac gaactaaagg 2641321 gagcggctta caaaacctgt gttctctatt tccttgatca caacacaaca attataggca 2641381 tacaaaaaaa ggaggggccg atgctttccc ctcctcttac atacaaggtg ctcgaaacag 2641441 atcaattcct tgccatctag tgtaacagaa catcctccaa ttctttcacg agagaggcgc 2641501 cgatatccaa aaatgccgga tcaatttccg cgtcccgcct ttccggttcg gaaaattgat 2641561 taaacagtga ttggaaaggc cctccctcgg cgtgatcgtc aacatccgcc tgaaacacct 2641621 gtctcagcat aaatggcgtt ccgatccgga cggccgcccc tcgttcatcg agactgccct 2641681 gtaccgcatt gacgggaatt cttaaaaata aatagccgtc tctatcatca attttataat 2641741 caaagtagcc atgatcgtat tcccagccgc cgtttatcac ataaccgagc ggcttcatca 2641801 cttgttccag ttcttgaagc agaaaagact gcccatctat cgcggaaggt attggtatca 2641861 tcagaatgcc ccttttttca cttatcctgt cccgccgaac aagacttcat tcagaggcgc 2641921 ctacatggaa atcgttgttt ctttcgcgcg gccaacagga aagaaagcgc attcaattaa 2641981 gaagtaaaca gccattgccg ctgcaagcca tacagctgaa tcccaagaca cataaacaac 2642041 cgttgcatag agtcctaatt tagtgaaaag agtatgggtt cgttttaaat gcaaaatccg 2642101 atgtaccgca tcggtaaaaa gggcaagcgg caaaccaatg agaagaaagg agtggatgaa 2642161 aaaatgtgac agcgtgccgc caaagcttga agaaaaccct gtatacacgg catcaaagga 2642221 gataaggaaa cttaaaatag ctgcagaaaa accggcaatg atgagatgtt taaccaattg 2642281 tttcatgaac atcagcacct ttctgatttt ataaaaagcc gaccggcaaa tgccagtcag 2642341 ctttctcaca ttaatcttcc agacgttttt caagctctgc ttttttctct tcaaagccag 2642401 gtttgccgag taacgcaaac atattgactt tatacgcttc tacaccaggc tggtcaaacg 2642461 gattgacgcc aaggaggtaa ccgctcatcg cgcaggcttt ttcgaagaaa tatacaaggt 2642521 atccaaaagt atatgcattc agctcaggaa tgttaacgat taagttcgga acatttccgt 2642581 ctgtatgggc aagcattgta ccttggaatg cttttttgtt aacgaaatca acagttttac 2642641 cggctaaata gttcaagccg tcaagatcgt tatccgcttc ctcaattgtc agttcatgtt 2642701 taggcttctc tacgttcagg accgtttcga ataaatctct gcggccttct tgtacatact 2642761 ggcctaaaga atgaaggtct gttgaatagt tcgctgaaga aggataaatg cccttctcat 2642821 ctttcccttc gctttctccg aacagctgct tccaccattc cgcaaagtat tgaagcgccg 2642881 gttcgtagtt gatgagcatt tcaattgttt tgcccttatt ataaaggaca ttgcgaacaa 2642941 ccgcatattg gtatgctggg ttatcttcca gttcagatgt tgcaaaatct ttgctcgcat 2643001 ccagggcgcc tttcatcatg tcgtcaatgt tgacgccgct gacagcaatc ggcaagagac 2643061 ctacagctgt taaaactgaa taacggccgc cgacatcgtc aggaattacg aatgattcaa 2643121 agccttcttc gttagaaagc gtttttaatg cgccgcgctc tttatcagtt gttgcataaa 2643181 tccgcgcttt cgcttcttct ttaccgtatt tctcttcaag aagcttgcgg aaaatacgga 2643241 aagcgattgc aggttcagtt gtcgtacctg atttagaaat cacattaata gagaagtcaa 2643301 catcttcaag aagatccatg acgtctctca tataagatga actgatgttg ttcccgataa 2643361 aaatgacttg cggattgccg cgttttgctt ttggcaaagt gttataaaac gcgtgattca 2643421 gcgcttcaat cgctgcccgc gctccaagat aagaaccgcc gatgccgaca acaagcaaga 2643481 catcagagtc agatttgatt ttttccgcgc tttttttgat gcgcgcgaat tcttctttat 2643541 cataatgttc agggaggtcc acccagccta gaaaatcgct gcccgcgcct gttttctcat 2643601 ggatattatg gtgtgctgtt tttacaaagt cccgcaggta tgtaagttca tgttcgttga 2643661 agaaagtcaa cgcttttgag tagtcaaagc gtacatgcgt cattgcttgt ccctccataa 2643721 cggtataatg ttttcatctt tcactttata tgaacttatc tgtgaaatca agtcaagaag 2643781 aaagggcgga atgactggat tccgcccttt gggtttatag agacgcgcga aggatggcaa 2643841 gcacgtcatc tttgttcagt ttttggaagt tgccgaagcc gccgtgttcc atttccttgg 2643901 ctgcgatatc agcaatcagc tcaagctttt cttctccaat attgtaatca gcaagacgag 2643961 aaggtgcacc gaggcttgtc cagaacgcag acagtttatc gattccttca agcgcaattt 2644021 ctttatctgt tttgccttca gtatcaatgt caaacatgtt gagcataagg tttttaaaac 2644081 ggcctacatt tgtatcaagc gtgtatctca tccaatttgg gaacagtatt gccaaaccgc 2644141 ccgcgtgcgg aatatcatat acagctgaaa cagcgtgttc cattgtatga gaagcccagt 2644201 caccgaagta tcccatttgg agcgtgccgt ttaaagcaat agtaccagca tacaaaatcg 2644261 tttcacgaag ttcgtagttt tccagatctt caagaagctt aggagctgtt tcgatgaccg 2644321 tctgcaaaac agcaaagcac attctatcct gaagcggcgt gttttcaaca ttatggaagt 2644381 attgttcgaa tacgtggctc atcatgtcaa ccatgccgta tactgtttga ttttctggaa 2644441 cggtgaacgt attttcaggg tctaaaatag agaaacgcgg atgagtgaca ttgctgcccc 2644501 atacaaattt ctcgtttgtt tcccagtttg taatcacgga atcagggttc atttcagacc 2644561 ctgttgcagc aagagttaaa acagtgccaa acggcagcgc atcctccgct gttacttttt 2644621 tgctgaaaat atcccaagcg tcaccgtcat atttgacgcc agctgcgatt gcctttgtac 2644681 agtcaatcac actgcctccg ccgacagcaa gcagaaaatc aatgtcatgc tctctgcaaa 2644741 gtcctatgcc tttttccact gtcgcaagac gcgggtttgg ctctacacct gacagctcat 2644801 gaacaacagc gccctcttct tttaaaatgc ctgtgacttg atcataaagg ccgttgcgtt 2644861 taatgctgcc gcccccgtaa acaagcagta cattcttgcc gtatcgtttg aattcttttc 2644921 ttaattgttc aagctgacct tttccaaaaa tcagctttgt cggattataa taagtgaaat 2644981 tttccatagt aaaacctcca aatgatgctg gtaaaaaaca gattttccat tgtaacataa 2645041 gttgacaaaa aagaaaaagg gaagcagcca aacggctatt tccccttttt ttatagtgat 2645101 gctttcaaaa ttgacagcac atcttctttg ttgagtgatt taaattggcc gaatgtaccg 2645161 ttagccattg ccttgtcagc gattgtgtca agctgctcat cattaatatc ataatcagca 2645221 agacggttcg gagcgccaag acttgtccag aatgcggaca gcttatcgat accttcaagg 2645281 gcaatttctt catccgtttt acctgcttct tcaacatcaa acacgcgaac tgcaagctgt 2645341 ttcatgcggg cagggttttc agacaatgtg tgtctcatcc aattcgggaa cagaatcgcc 2645401 agtccgccgg catgcggaat atcataaacg gctgatactg catgttcaat attatgagta 2645461 gcccaatccc ctcttgcccc catagaaagc atgccgttta atgcgattgt tcctgtgtac 2645521 aggatcgtct cacgcaattc gtaattttcg agatcattga tcagcttagg cgctgtttca 2645581 atgactgtac gcaaaagtga ttcacacatg cggtcctgat acggcgtgtt tgatacatga 2645641 tggaagtatt gttcgaatac gtggctcatc atgtcaacca tcccgtagat cgtgtggttt 2645701 ttaggtacgg tgaatgtatt caccggatca agaatcgaga atttagggaa tacgagcggg 2645761 ctgccccagc cgtatttttc ttttgtttcc cagtttgtaa taacagatcc tgagttcatt 2645821 tctgaaccag ttgcagcgag agtcaatacc gttccgaatg gcaaagcatc ttttggctga 2645881 tgctttttcg taacgatatc ccacgcatca ccatcatact tcgctcctgc ggcaatcgct 2645941 tttgtacagt cgattacgct tccgcctccg acagccagca agaaatcaat gttttgttct 2646001 ttacagatgg caacaccttt attaacagtc gacacacgag gattcggttc cacacctgct 2646061 aattcatgca cggtcgctcc ggctttattc agctgttcaa tcacttgatc atacaggccg 2646121 ctgcgtttaa tgctgccgcc tccgtacaca agcaatacgt tttttccgta aggtttgagt 2646181 tcctccggaa gtctttccac ttcgccgcgc ccgaaaatta atttggtcgg attccagtat 2646241 gtaaagtttt gcatgacatc tcctccttag attttttatt atgcagaatg tcctcaccac 2646301 atgtaaagca atcagctctc accgatcagc ataccagatg gttttatttt gcaaggtgct 2646361 gggaaagaag ctgatataag cgagggcagg ccagcttccc tcatatggag aatgcatgta 2646421 tagattctcc aatatgtcac aatctataac tgttttaata attcatggag gaggttgcaa 2646481 aacatgagta ccattcaaag aatttgtctt gtattaacca tcattggcgc cattaactgg 2646541 ggactgatcg gatttttcca atttgactta gtagcggcta tcttcggcgg ccaagggtca 2646601 gctctttccc gaatcattta cggacttgtc ggaatcgccg gcttaatcaa cctcggtctg 2646661 ctatttaagc caaacgagga aagatcacgt gaagaagcag caaatcctga aatgcgatag 2646721 gatatcaatc acgctgaaat aggattttgc atgaaatcaa aagcaccgaa cattcctgtc 2646781 cggtgctttt ttcatgctta ttttttgata aggtctttgc ggttggacat ttcgatccac 2646841 tcttcaagct tatcttttaa tgtgttgaaa ccttgtggtg tagaagcttc ttcgcttact 2646901 tgagcagctt taggttttct tggtttgctt tcttttttct caggcgcagc ttgtgtcgca 2646961 cgaattgaaa ggctgatttt gcctttttct tcatcaacag caagtacttt tacttgtact 2647021 tcgtcgccaa ctgaaaggtg ctcgttgata tcttttacga aaccgtgagt cacttcagaa 2647081 atgtgtacta aaccttgagt ttcttcatct aatgcaacaa acgcaccata cgcttgtaat 2647141 cctgtaactt taccagtgta aacactgccc acttcaaatt ttgctgccat tcataacaac 2647201 tcctaagtta aattaaatat ctgtttatac gcaatttaaa attatatcac acatgtctta 2647261 tttccgcaaa gaaaactttt ttataaaaaa tcaggtttat gcacagcaaa aagggggtaa 2647321 actgaaaata ccaaaggctt tctagtattc ccccctttta ttggatgcga acaaaaggtt 2647381 cgtatctttt tttatgttgt tttgtgcagg aagcgtttca ttctgactaa cgcttcttga 2647441 agctgttcaa tcgaggttgc gtatgaacaa cggatatatc cctcaccgct cggaccaaac 2647501 acacttccag gaacaactgc cactttttcc tgcgtcagta gctcctcggc aaactgttct 2647561 gaactcattc ccatgctttt gatagatgga aaagcataga aagcgccgcc cggatgatga 2647621 cagctgagac cgatttcatt gagcgattct acaaacagat tccgtcttct tcgatagctt 2647681 tttttcattt tttctacgtc ttccatgccg ttcttcaggc cttcaagggc ggcaaactgc 2647741 gccattgcgg gcgcgcacat catcgcatac tgatgaattt taagcatggc atcccgaagc 2647801 aaggatggtg ccgcggcaaa accgagcctc cagcccgtca ttgcaaatgc ttttgaaaag 2647861 cctgagatga ctaccgtccg ttccttcatt cccggtaatg ccgctatact tgtaaattcc 2647921 tcatcatatg tcagctccgc gtagatctcg tcggctaaga cgatgacatc atgttttttg 2647981 gcaaactcag caatctcatt cagctcttcc ttcgaataaa ccgaacctgt cggattcgat 2648041 ggtgagcaga tgagaatggc ctttgttttt tcagtgactg ccgcttcaaa atcagcagcc 2648101 gttgctttaa atcctttgtc tgccgttgta tgaacgtgaa ccgggatacc gcctgccaaa 2648161 gaaacaagcg catcgtacgc aacaaaacac ggctcaggaa tgatgacttc ctcacctgga 2648221 ttcacaatgg cgcggatcgc aatatccaaa gcctgacttg cccccactgt cacaatcagc 2648281 tcattatctg gcgagtagct aaggtcaaac ctgttgctca aataacggct gatttcctcc 2648341 cgcaatgagt ataaacccgc attggccgtg tatgacgtat atccttgttc aagagagaga 2648401 atgcttgctt cgcggacatt ccatgcggta acaaaatcag gctcgccgac gcctaaagaa 2648461 atgacgcctt ccatcgttgc cgccaaatca aagaatttgc ggatgccgga tggttttatt 2648521 tgttgtacat agtctgataa atacgaagtc atttacggtg acaccacgat tcttttgtcg 2648581 tcgtctcctg tttcaaacac tttgccgtca tgcttgtatt ttttcaggat aaaatgggtt 2648641 gtcgtagata caactgaatc aagcgttgag agtttatccg aaacaaaacg cgctacgtca 2648701 gacatcgaat tgccgcgaat cacgacagac aaatcgtata cgcctgacat caggtaaact 2648761 gattcaacct cttggaatcg gtaaatccgt tccgccactt catcaaaacc gacgccccgc 2648821 ttcggcgtta ctttgacgtc aatcatggcc gtaacgccct catgtccgtc gacttttcgc 2648881 cagtcaatca tagcggaata atcgataata accttttctt tctccagttt gtcaataatt 2648941 gttttcactt catttacagg gatgcccgcc atctttgcga ttgtttctaa atcggcgcgg 2649001 ctgttttcgt ctaaaatttc taatatttct gtttcttttt ctgtcaattt catttgattc 2649061 acacctttgc aatgtcaaga aatctcatga cattatatca cgttttttga cgaatgctaa 2649121 gaaaaaacga ggagaaactt ccgctagaat tgacaatttc agggcataat acaaccatca 2649181 aaaaaaggga gtgacacaga atggaggcgg tttcaccaat aaggcggttt acggtcgatg 2649241 gagtcaatgt atactacgaa cattatcaaa atcccggcag gcaaacgctg gtctgcgtac 2649301 acggtttttt atcatctgca ttcagcttca gaaaagtaat tcctctcctt cgggacaagt 2649361 acgacatcat cgcgcttgat ttgcctcctt tcggccaatc tgaaaaatca agaacgttta 2649421 tctataccta tcaaaacctt gctaagcttg tcattgggat tttggagcac ttgcaagtga 2649481 aacaggctgt gcttgtcggg cattctatgg gcgggcagat atcgctgtct gctgctctcc 2649541 aaaaacctga gcttttttca aaggttgtgc tgctttgcag ttcagggtat ttaaaacgtt 2649601 cacacccgac gattattttc gggacccata tcccgtattt tcatctttac atcaaacgct 2649661 ggctctcgaa agaaggcgtg atgaaaaatt tattaaatgt ggtgcatgac aaatcgctga 2649721 ttgatgagga gatgattgac ggctatggca gaccgtttca ggacgagcag attttcaaag 2649781 ccatgacaag gtttatccgc cacagagaag gagatttaga acccgagcaa ttgaagaaaa 2649841 tgaacaagcc tgctctattg atttggggcg aggaggatcg aattgtccca atggagatcg 2649901 gtaaacggct gcacgcagat ttgcctaatt ccgtgctgta ctcacttggc cagaccggac 2649961 atctggtgcc tgaagaacgg cctgaactta tttctgaaca cattgctgat tttatcaaat 2650021 aacaaaaaaa ccggtgctga accggttttt ttaaggcgtg caggagctgc tgtttttaat 2650081 gaataaaagc tggccagcca cttcccggca gctggcgatc ggcagcgttt gttcaaaaga 2650141 agtttcaaat atttgctgaa tgcttttcgc cagcaagtcg ggatcgtttt catcatagac 2650201 tgcctgcacg acatcaacag cctccgtttc gtaaaactct tctccatatt taaacgggtc 2650261 ccatttggca atgatcttaa tcatttccct gaccgcatga ctttcttcca tattcatcac 2650321 cgcttataat aaaatttgca gttctatctt atcatagtga agcttagaag aataaacata 2650381 catgaggggg taacagaatg aactttgata aacgagaaga acgccttggc acccaatcgg 2650441 tcaaatggga taaaacaggc gaattatttg gcgtgacaga cgccctcccg atgtgggtgg 2650501 cagatatgga ttttcgcgcc ccggaagcga taactgaagc gttaaaagag cgtcttgacc 2650561 acggtatttt tggttataca actccagatc aaaaaacgaa ggatgctgtg tgcggatgga 2650621 tgcaaaacag gcacggctgg aaggtaaatc cggaaagcat cacattcagc cccggcgttg 2650681 taacagcttt gagcatggcg gtacaagctt ttacggagcc gggcgatcaa gtagttgttc 2650741 agcctccagt ttatacgcct ttttaccata tggtggagaa aaacggccgg cacattttac 2650801 ataatccgct gctagaaaaa gacggcgcat atgcaatcga ttttgaagat ttggagacaa 2650861 agcttagtga cccaagcgtt acattgttta ttttatgcaa tcctcataac ccttctgggc 2650921 gttcatggag ccgggaagat ttactgaagc taggcgaatt gtgccttgag catggcgtca 2650981 cagttgtatc ggatgaaatc cattccgatt taatgctgta cggacataaa cacacgccgt 2651041 tcgcttcgct ctctgacgat ttcgctgata tttccgtgac atgtgctgct ccaagcaaaa 2651101 catttaatat cgccggattg caggcttcag cgatcattat tccggatcgc ctgaagcgcg 2651161 ccaagttttc cgcaagcctt cagcgaaatg gtttaggcgg actgaacgcg tttgccgtca 2651221 ctgcaatcga agccgcgtat tcaaaaggcg gaccgtggct tgatgaattg atcacttaca 2651281 ttgagaaaaa catgaacgaa gcggaagcct ttttgagcac cgagctgcca aaggtcaaaa 2651341 tgatgaagcc ggatgcatca tacttgattt ggctcgactt cagcgcttac ggcttgtccg 2651401 atgcagagct tcagcaaaga atgctaaaaa aaggaaaagt tattttagag cccgggacga 2651461 aatacgggcc tggcggagaa ggatttatgc gcctgaacgc cggatgctct cttgcaaccc 2651521 tgcaggacgg cctgcgccgc atcaaagccg cattatcgta aatatagctg taaacgcctt 2651581 tacgtcttca tttgtaaagg cgttcttaat aaaggaattt tatattttac ttctaatatt 2651641 tagtgttata atagattcat attttatacg aaaggatttc acacgaatgg aaattctaaa 2651701 agactatctt ctgcacatct gctttatttt gtttcctatt cttctttacc aagtgttttg 2651761 gcttggaaaa cctgcgattc ttgtgccaaa aataaacagc ggtttggtca cgctcttcgc 2651821 ctgcggcgcc tccgttttat gcattatttt cccgattcat gaaatggact acatacaata 2651881 cggccttcag atgattcccg ttatcatttg tttattttac attagtaccg cttccggact 2651941 tacagtcgcc gcatctgtcc tatgttttga actgcttttt tacgaacctt ccgcaatgtt 2652001 tgttttcact ttgctgcctt ttcttatcat tatcccaatc ttatttcaga aaaaatggcc 2652061 attcatgtcc aaagcgaaaa aactgctgct gtctttattg atcagctgcg tggagatttt 2652121 cctatttttc gcctcaagct ggattctttc cgccttgaat attttaaatt ttcaaaaatc 2652181 aggaattttc gtttacgagg cggcagtctc agggcttttc cgctccagtg ttcttctatt 2652241 aagcatctat attatcgaaa gcatcgccga aaatatcgcc ctgcgttcac agcttatcca 2652301 ttctgaaaaa atgacgattg tgagtgaact ggcagcgagc gtcgcccatg aggtcaggaa 2652361 tccgctgaca gttgtccgcg ggtttgtcca gctgcttttt aatgacgaaa ccctacaaaa 2652421 caagtcgagt gcggattaca aaaagcttgt actgtcagag cttgaccggg cgcaaggcat 2652481 tatcacaaac tatctcgata tggccaaaca gcaattatac gaaaaagagg tttttgacct 2652541 atctgccctt atcaaagaga caagctccct tatggtgtcg tacgccaatt acaagtcagt 2652601 aaccgtcgag gctgaaacag aaccggacct tttgatatac ggagacgcaa caaagctgaa 2652661 gcaggctgtc atcaacctga tgaaaaacag tattgaagcg gttcctcacg ggaaggggat 2652721 gatccacata tcagccaaaa gaaacggcca tacgatcatg attaacatca cagacaatgg 2652781 ggtcgggatg acagaccatc aaatgcaaaa actcggcgaa ccttattatt ccttaaaaac 2652841 gaacggaacg ggactcggcc tcaccgtaac cttttccatt attgaacatc atcacgggac 2652901 catttcattt aacagcagct tccaaaaagg cactacggtg accattaagc ttcccgctga 2652961 tcttcctcac tagcaaatcg attggaactt taatagaata aatgcgaggt gatgacagat 2653021 gagcacgttt gagacaggct ctatcgttaa aggattttac aaaacaggtg tatacatagg 2653081 agaaatcacg gcttgcaggc cgcagcatta tttagtgaaa gtgaaagcgg ttcttaccca 2653141 tcccgctcag ggagaccttc atcatccaaa acaggcggat gtgccatttt ttcatgagag 2653201 aaaagcgctc gcatatggtg aacagaccaa tatcccccac catatggtga agccttatga 2653261 cggtgaagtg ccggattata ccgaatctct gcgggaggcg acagcacaga tgagagccaa 2653321 attgaatgag gatggttcgg agtgggcaaa gcgctccctt cataatctgg acattttaga 2653381 aaaagaatat tttaaccggc cataacccag tctgacaaaa gattgggttt tttacgtcgc 2653441 gcgcttcaac agttcggtta aatcgattct ctcgccgatt gtgggcggtt ttggcttttc 2653501 gagatactgc ttatcctgct caacaagctt aaaaagttta tatgctgtga gagcatcatc 2653561 aagcgcttta tgatgggtgc cggttccgga atctccatac tcttcggcag ctttccataa 2653621 acccgtcaat gtccggtctc caaaaaagtt tttgtattca agcgataaat ctctcatttc 2653681 tcccttaaac gggaaaggga tatggttaaa catacagttt tgcttcagca ctttcatatc 2653741 catgtttccc cacgtaataa ttgtgctgtt tttctcagga tccagctcgt ttagtttacg 2653801 gatgaaatcc tcgaatctca ttccttcgtc tacctgtttt tgggttattt ttaaaaatga 2653861 tttgcagcgt ttcgtaagct tcgggaactt tttcggtcta acatagctag aaaacgtctc 2653921 aaccacttca tcatcaatcg actttacaat tccggcttca atgatttccg ggaagaagtt 2653981 ttgaggactg tactttccat caggcattgt aaattcgaaa tcaataatga gtaagctgtt 2654041 tgtcgtcacc ttttacacct gcctttcctc cgatcagaaa atgctatctt tatagtatat 2654101 caattcccct tctcgacatt tcttcatttt ctaaaaataa tgaattttcc cagccgcttc 2654161 gtttctttta aattgtgaat cgtttcttta taattagtaa ggaacccgaa ataataagaa 2654221 ggtgatgtta tttctatccg taagaaaaac tttgtcattg tgtggctggc gaactttttt 2654281 gtctccgcta gcacaacgat gatcgttcct tttctctcct tatacattga gacgctcagc 2654341 tctttttcaa acggctttgt gcaaaggtgg agcggctatg tgttcggcat tacatttctc 2654401 atggcgtttt tggtatcccc gttttgggga cggttcggag acaaacgcgg atacaagaaa 2654461 atccttatgg caaccggaac aggcattgcc ctcagcattt tcttcatggg ctttgttaca 2654521 tcggtgtacc aattgttttt tctgcgtatg gcaatgggtc ttgtaaccgg attcatcccg 2654581 acatctcttg cgatgatttc ggcacagact ccgaagagct cagctggcaa aacactcggc 2654641 acgctgcaaa tggggcaagt gtccggaagc ttgttcggcc cgcttttggg aggcatgctt 2654701 gctgatcgtt tcggctttac gtataccttt tttatcacat cctttgtgat tttctcgtct 2654761 gttcttctcg tgttatttgg tgtcaaagaa aagcatcttg cagagaaaac agccaaacgt 2654821 acgtcttact cgagaaaaga agtgctctcc tatatttttc accatccggc gctgtgggtc 2654881 atgatgctgt taaccatgct gattcaaaca ggcaatttca gtatccagcc cctgctcgct 2654941 ttatatgtaa atgagctgca cggacctgtc aatcttgcct ttttctccgg catggcattt 2655001 tcagcaacgg ggctcggaag tttgctgctg gctagaaaat ggggtgatct gggcgaccgc 2655061 tacggccacc gccgcatttt aatcggactt ttgctcgccg cctctttctt ttttattccg 2655121 caggcgctcg cgtcctcact cagcgtgctc cttgttttca gatttttatt cggaatggcg 2655181 atgggcggtt tgctgccatg cattacggca gcgatccgcg ttcaggctcc cggcagcatt 2655241 caaggtgaag ttctcggcta caatgtcagc tttcgctttt taggaaacgt gctcgggcct 2655301 ctgctcggcg gaatcatatc gagccatttt accatttcgg ccacctttta cgtcacggcg 2655361 tttctctttt tcgccggcgc ctgcatgctt tggatcatgc agaaacttcg gaaagattct 2655421 tatgccaaag caagctgatt ccgagaaaaa actaaggaat cttctaaatt taaccttctc 2655481 gtaatctcaa aagaatggta cgatatggct agaatttagg agaaaagaga gtgaccatgt 2655541 tacgaaaaat aatcggatgg attttgctcc tttgcataat cccattgttt gcatttacag 2655601 ttatcgcttc cggaaaagaa gtaaaacaaa tgaagtccct ggatcaggtg cttgataaaa 2655661 atattgatct gaaagatatc agccttgttc agaacagcta catgtatgac agggacggct 2655721 cccttgtctc ggaaatcgtc agcgaccacg aaaaccgtgt gctcgttcca tttaacaaga 2655781 ttcccgagga agtcaaacag attttcttaa catctgagga ccgccatttt tacgagcata 2655841 aaggctttga ctttatggga atggtgcggg ctactgcttc taacgtaaaa gacaagaaaa 2655901 ttgaccaggg tgccagcacc atcacacagc agctttcaag aaacttgtat ttgagccacg 2655961 aacgctcctt cagccgcaag ctgacagagc tcgcgtattc ctatcagctg gagaaaaaat 2656021 atacgaaaaa tgaaattctt gaagcttact taaataccat ttatttcaac aacggtgttt 2656081 acggcgtcgg ttcagcagct caattctatt tcagcaaacc gctgaaatct ctcacagtgg 2656141 gagaaatggc ttttatctgt gctataccta ataaccctac attatatgat cctctcaagc 2656201 attttgacta cacgaaaagc cgtcaagaac gtttacttaa agggctaaaa gatgccgggg 2656261 tcattacgga caaagagctg aaaaaagccg taaaacaaaa aatcaaactg gatgttgaaa 2656321 aaagagaaga caaatatcct gactacgttt cctacgtcaa tgatgaattc actcagctgg 2656381 tgtctgaatc agaaggcttt gataaacgcc ttcaaaaagc atcaggaaaa caaaaagaaa 2656441 agatcgagaa cgagctgtcc gcaagagtca gcacgctgat gaaagacgga gtgaaaattt 2656501 atactgcact tgatccgtac atgcaaaatc aagttgtggc acaaatgaat tccaagctcc 2656561 cgtatgcgga cgtacagggc ggagcggctg tgattaatca ccagacgcat caaatcattg 2656621 ctctatccgg cgggaaaaac tatcaaaaat atgactttaa ccgcgcctac caggcgtaca 2656681 ggcagccggg ttcatccatt aagccgcttc ttgattacgg cccttatatt gaacagaccg 2656741 gcgcgacaac aagcagcacc attgatgcca gcaagttttg cagcaaagac tactgtccgc 2656801 aaaactacaa taaccgcact tacggcacag tgacgcttga tacggcgttt aaaaattcat 2656861 ataatacccc ggctattaga atgctcgacc gcgtcggcat ccaaaaggca ttcagttata 2656921 ttgagccgta tcattttgcc aaacttgtcg acagtgacta tcttcttccg gcggcgcttg 2656981 gcggatttac aaacggcatg acgcctcttg agatgacaaa ggcttatacg acattcggaa 2657041 acagcggaag ctatacgccg agccatgcga ttacaaaggt gacagacctt aaaggaaaaa 2657101 cactttataa atggaatgat aaagcgactc aaatattcag cgtccgcacg aacatgcagc 2657161 tgaaaaaact gatgtcttcc gttgtgaaaa gcggaacagg gaaaaaagca tatttcaatg 2657221 cgccttacat cggcggtaaa accggaacat caaatgatta tcacgatatg tggtttgtcg 2657281 gcctgactga tacgtataca atgggtgtct gggtcggaaa ggatacaccg accagcgttg 2657341 aatatcttca cagcatcagc cctcagcttt ccatctggaa aggaacgctg caagcggctt 2657401 attaaaggat cggaggggat atggagtgac ttcagaacaa attccaaatc gcgttttgct 2657461 gtttgacggt gtctgcaatt tatgcaatgg cgccgtgcag tttatcatta aacgtgatcc 2657521 ggacggattg atttctttca catcgctgca gtcggaaaca ggacagagcc tgctgaaaaa 2657581 aagcgggctt ccgactgatc ggtttgacag ctttgtcttt attgaagacg gccaagtgta 2657641 cacaaagtca actgcagcca ttaaggtttt caggcatctg cgaggcccat ggcggctctt 2657701 cgtccttttt ttcgcagtgc cgaagcctgt cagagatatg gtctattctt tcattgccaa 2657761 aaaccgctat aagtggtttg gcaaaaaaaa tgaatgtatg ctcccctccc cttccattaa 2657821 aaaaagattt ttaccgtaaa taaaaaatgg ctaggaagct agccatcaca gattgttgac 2657881 aaaatcctaa aacggcttcg ttttaggatt ttgtcatcta ttcagcgtga ttgaaaactt 2657941 ttgaagttgt gaaacggcgg aaacctgaga atctagccgc cgtttcattg cgtacagagc 2658001 acgaagcgca aatctgacca ccaaacgctg aaatggctag cttacacagg taagctagcc 2658061 attatgctat tataaagctt gataaatatg aacagaatac cgataacaaa ggtaaaccaa 2658121 aacagcagtt ccaatagaat gaatccaact aatgacatga gagaaagcgt cgaataaatc 2658181 cggtatacgg taaacacaaa gtaagcgagc gtgacgaccg caaaccagat cacaatccaa 2658241 atgacatttt gcaagagcac aaaggataaa atcccgccgc ccaaataaat catggaaccc 2658301 attctgagtt ttttcaggtt gttcccttcc ggatcattag caaaaaacag caatgacagc 2658361 tcggtcacgg tatttgcaat taatttcaga gcggacagaa ccataaaata taaaagtgca 2658421 aaggcagcaa ataacgcaag cctgattcct ttctctgaaa aataatcgag cattccatca 2658481 tacattccaa atgaagacag catcttcaac gcataaagtg aagttgagat ggataaggac 2658541 gaactaaaaa gcaggatcgc aatcagcgga aaatatcctg tcaaataagt atttttcata 2658601 taaaaaagtc cctttctata atctacctca tttattatgg aggacttaaa acacattgac 2658661 aagataaatt attccatttt ttctcctttt tacgaattac gggcccaaat cttcacaaag 2658721 cagcattttg agagtaaagt agtacgcagg aatcataaaa cgtaaggaag ttttatatga 2658781 aaaaaacatt aaaactgcaa accagactca ccatatttgt ttgtatcgtt gtattaatcg 2658841 cattgctcat tacgtttttt acagtcggtg cccaaaccac caaacgaatt agagatcagg 2658901 aaaaggccac tgcgctgcag actgctgaaa tggtagctga agcgccgatg acagccgctg 2658961 ctttagaaag cggaaaaaaa caaaaggaac tgcagagcta cacaaagcgg gttcagaaaa 2659021 ttaccggcac ggaatttgtt gtcgtcatgg atatgaacgg tatccgcaaa actcatcctg 2659081 acccgagcaa aatcggaaaa aaattcagag gcggtgatga gtccgaggta ttaaaagggc 2659141 atgtccatat cagcacagcc tctggcacgc tcgggaaatc gcagagagcg ttcgtccctg 2659201 tctacgcgga gaatggaaaa caggtcggtg cagtcgcggt cggcatcacc gtaaatgaaa 2659261 ttgatgaagt gatcagccat agcttacggc cgctttactt tattatttgc gtcagcatct 2659321 tcgtcggtgt gatcggagcc gttatcgtcg cccgtacagt gaaaaatatc atgtacggac 2659381 ttgaacctta tgaaattgcg actctgcttg aagaacggag cgcgatgctg gaatcgacga 2659441 aggaaggaat actcgctgtc gatgaacatg gcaaaattaa acttgccaac gcggaagcaa 2659501 aacgcctatt cgtcaaaatg ggcatcaaca caaatcccat tgatcaggat gtagatgaca 2659561 tcttgccgaa aagccgcttg aaaaaggtca ttgagacaaa aaaacctctt caagacagag 2659621 acgtccgcat taacgggctg gagcttgtgt ttaatgaagt tcctatccag ctgaaaggac 2659681 aaactgtcgg agcgattgca acattccgcg acaagaccga ggtaaaacat ttagctgaac 2659741 agctttccgg tgttaaaatg tatgcaaacg cactgagagc gcagtctcat gaatttatga 2659801 acaaactgca tgtgatatta ggtctcgtcc agctgaaaga gtatgatgat cttggagatt 2659861 atattaaaga tatagccata cagcaaaaat cagaaacaag tgaaattata aatgatgtca 2659921 aaagctccgt actggccggt tttctgcttg gaaagcaaag ctttatacgt gagcagggcg 2659981 caaatcttga tattgaatgc aacggtgtca tcccgaacgc ggcagaccct tctgtcatcc 2660041 atgaacttat tacaatcatc ggaaatctca tcaacaatgg cttagatgcc gttgccgata 2660101 tgccgaaaaa acaaatcacc atgtccatgc gcttccataa cagcatactt gatattgaaa 2660161 ttaccgatac tggagcaggc atgtctgaag aagaccaagc caaagtattt gaacaaggct 2660221 attcaacaaa gggcaaaaac cggggattcg gcctttattt cacacagcaa agcatcgaaa 2660281 atttaaaagg ccaaatgatc ctcacaagcg aaaagaatga aggaacgaca ttcagtattc 2660341 gcatcccgta cgaaccgaag gaggaaaatc atgattaatg tactaatagt tgaagatgac 2660401 cccatggtgg gtgaattaaa taaacgatac ttaagccaaa tagatggctt tcagctgaaa 2660461 ggcatcgctt cttcctttca aagcgctctg catattttag gggagcacca tattgacctc 2660521 attttgcttg atatttatat gccgggaaaa aacgggctgg aactgctgac ggaattgaga 2660581 gcccaaaatg aagcggttga cgtgattgtc atctcagcgg ccagcgagct tgacgtgatc 2660641 aagaaaacac ttcggtacgg agctgttgat tatttaatca aaccgtttga atttgaacga 2660701 ttccaaacgg ctctgtctga ttacagacga aaacaaaagg tgtattcaac ccatcgcaac 2660761 atgagccaaa aagaactgga cgccgagctt tttcaaaaga aagaagcaac agaaaaagtg 2660821 cagcttccta aaggcctgac aaaaagcacg ctgaagctga tctggtccag tatccagtca 2660881 tttgaaaatg aatcttttac gacagaagac ttggcaaagc acacagaaat ctctcaagta 2660941 tccatacgaa aatacttaaa gtttcttgaa gatatacagg ttctgaatgt agaaatggcg 2661001 tacggaacga tcggaagacc tgtgtttcag tacaacgtca acaacagtaa cattaacgga 2661061 ataaagcaat atctataaga aaacgcactg cttgctttga gcagtgcgtt tttctgtcat 2661121 atctcttgcc aagatgcttg attctattgt tgataagtta tacaagaata acaaagggct 2661181 ttcacatttt taagcaaata attctaaaaa tagataattt ttaaaaaatt atgcgaaatt 2661241 ctatttattt cttattagtt aaatgataaa ttatgattgg ttagttgatc ccgaaaaact 2661301 aagtcataag tcttacttca gaaaacgatg tcacggtttt ccgcccggaa cgccttccgc 2661361 atccttctct tccccgcctt tcgaaggaaa tactcacacc acgcttattc agggaagaat 2661421 agaactgtct cagcgcattc catttgttat tatcagaaaa ttttatcgat tctaagaaat 2661481 tgttcaggac agcccatcac atgactggcc ggatcagctt tgaaccaaat ttttctgggg 2661541 ggttatatct tgaataaacg aaaaatcgga ttggcgatgt cacttgtgat cgcagcaggc 2661601 accatattag gagcatgcgg aaacagcgaa aaaagcagcg gctcaggcga aggcaaaaac 2661661 aaattcagtg tggcgatggt tactgacgta ggcggagtgg atgacaaatc cttcaaccaa 2661721 tcagcctggg aaggcatcca agcctttggg aaagagaatg ggctgaaaaa aggcaaaaac 2661781 ggttacgact atcttcaatc caaatctgat gcagactata caacgaactt aaataaattg 2661841 gcgcgtgaga attttgactt aatttacggc gtcggctact taatggagga ttcaatcagc 2661901 gaaattgctg accagcgtaa aaatacaaac tttgcgatta tagatgctgt tgtcgataaa 2661961 gacaacgtcg caagtattac gtttaaagag caggaaggct catttctcgt cggagtggcc 2662021 gcagccctat caagcaaatc aggaaaaatc ggctttgtag gcggcatgga atcagagttg 2662081 atcaaaaaat tcgaggtcgg cttccgtgcc ggcgtgcaag cagttaaccc taaagccgtt 2662141 gtagaagtga aatacgcagg gggtttcgat aaagccgatg tcggtaaagc aaccgccgaa 2662201 agcatgtata aatcaggcgt agatgttatt tatcactctg cgggcgccac tggcacaggc 2662261 gtctttactg aagcgaaaaa cctgaaaaaa gaagatccaa aacgcgatgt ctgggtcatc 2662321 ggtgtcgata aagaccaata cgcagaaggc caggtagaag gaacagatga taacgtcacc 2662381 ctcacttcca tggtgaaaaa agtagataca gtcgttgaag atgtaacgaa aaaagcgagt 2662441 gacggaaagt tcccgggcgg cgaaacactt acctacgggc ttgatcaaga cggagtcggc 2662501 atttctccat ctaaacaaaa tctatcggat gatgtgatca aagcggtcga taaatggaag 2662561 aaaaaaatca tcgacggatt ggaaatcccg gcaactgaga aagagctgaa aaccttcaaa 2662621 gctgaataag aatcgcaggg ataaggaggt cgagccctta tcccttgttt ttcttttatt 2662681 ttgaaataaa ggagcggtca atcaatggaa tatgtcattg aaatgctcaa tatccgcaag 2662741 gcgtttccag gtatcgtcgc caatgacaat atcaatcttc aagtcaaaaa aggcgaaata 2662801 cacgcgttgc tcggtgaaaa cggagcgggg aaatcaacat tgatgaatgt ccttttcggg 2662861 ctgtatcagc cggagcgggg tgaaattcgg gtgcgcggcg agaaggtgca catcaacagc 2662921 ccgaacaaag cgaatgacct tggaattgga atggtgcacc agcactttat gcttgttgac 2662981 acctttacag ttgctgaaaa tattattctc gggaaggagc caaagaagtt tggcagaatt 2663041 gaccggaagc gtgctggcca agaggtgcag gacatttccg atcgatacgg cctgcagatc 2663101 catcctgaag caaaagcagc tgacatatca gtcggtatgc agcagcgcgc agaaatatta 2663161 aaaaccctct accgcggtgc cgacattctg atttttgatg aaccgacggc tgttttgacg 2663221 cctcatgaaa ttaaggaact gatgcaaatt atgaagaacc tggtcaaaga agggaagtcc 2663281 atcatcttaa tcacccataa gctgaaagag attatggaga tttgtgaccg cgttacggtt 2663341 atccgtaaag gaaaaggcat caaaaccctt gatgtccgtg atacaaacca agacgaactc 2663401 gccagtctaa tggtcggccg tgaggtatcg ttcaaaactg aaaagagagc tgctcagccg 2663461 ggagcggaag tgcttgcgat tgacggcata actgtaaagg atacccgcgg aatagagaca 2663521 gtcagagatt tgtctctttc tgtcaaagcg ggagaaatag tcggcatagc aggcgtcgac 2663581 ggaaacgggc aatctgagct gatcgaagcg gtgacaggac tccgcaaaac agattcagga 2663641 acaatcacct taaacggaaa acagatccaa aacctgacgc caagaaaaat cactgaatcc 2663701 gggatcgggc atattcctca ggatcgccat aaacacggtc tcgtccttga ttttccaatc 2663761 ggagagaata tcctgctgca aagctattac aaaaagccgt attcagcatt gggcgtttta 2663821 cataaaggcg aaatgtacaa aaaagcacgc agcctgatca ctgagtacga tgtcagaacg 2663881 ccggatgaat atacacacgc tcgggcattg tcaggcggaa accagcaaaa agcgattatc 2663941 gggcgggaaa tagaccgaaa tcctgattta ttaattgccg cccagccgac tcgcggcctt 2664001 gatgtcggag cgattgaatt tgtccataaa aagctcattg agcagcgtga tgccgggaaa 2664061 gccgttcttc tcctctcgtt tgagcttgaa gaaattatga atctcagtga cagaatcgcc 2664121 gttatttttg aaggacgcat tatcgccagc gttaatccgc aggaaaccac tgaacaggag 2664181 cttggtctct tgatggcagg aagcacgcaa aaggaagcgg ggaaagcaaa tggttaaacg 2664241 actctctcat ttactcgtgc cgctcatcgc aatcatactt ggtcttgcgg ccggcgcgtt 2664301 gattatgctt gtgagcggct acagtgtggc tagcggatat tcggctttgt ggaatgggat 2664361 attcggagaa atctattatg tcggagaaac aatccggcaa attacgcctt atattttatc 2664421 cggattggct gtcgcctttg cattccgaac cggactcttt aatatcggcg tcgagggaca 2664481 gctgctcgtc ggctggacag cagcggtttg ggtcggtacg gcgtttgacg gaccggcata 2664541 tattcacttg ccgctcgcat tgattacagc ggcagctgca ggaggattat gggggtttat 2664601 tcccggcatt ttgaaagcgc gattttacgt tcatgaagtc attgtcacca ttatgatgaa 2664661 ttatatcgcg ctgcacatga ccaattacat catttcaaac gtcttgacag atcatcagga 2664721 caagacgggg aaaattcacg aatccgcctc cctccgctct ccttttcttg aacagatcac 2664781 cgattactca cggctgcatt tgggaatcat cgttgccctt ctcgcagcag ttatcatgtg 2664841 gtttatcatc aacaaatcta caaaaggatt tgagctccgg gcggtcgggt ttaaccagca 2664901 cgcttcccag tatgccggca tgagcgtgcg gaagaatatc atgacctcca tgcttatctc 2664961 cggcgctttt gcaggtcttg ccggagccat ggagggccta gggacattcg aatacgcagc 2665021 agtgaaaggc gcatttaccg gcgtaggctt tgacggtatc gctgtcgctc ttctcggggg 2665081 aaacacagcc gtaggcgttg tactggcagc atgcctgctt ggcgggctga aaatcggcgc 2665141 attaaatatg ccgattgaat caggcgttcc atcagaggtc gttgatattg tgattgccat 2665201 tattattcta tttgtggctt caagctatgc gattcgtttc gtcatgggca aattgaagaa 2665261 aaagggggcg aactaagtgg acattgtgca gattttatct atcattgtcc ctgccacact 2665321 cgtctatgcg gccccgctta ttttaactgc tctcggcggc gtgttttccg agagatcagg 2665381 tgtggtgaat atcggcctag aaggcctcat gattatcggg gcgttcacca gcgtgttatt 2665441 taatttattt tttggtcagg aattaggtgc cgccgcacct tggctttcgc tccttgccgc 2665501 catggcagca ggcgccctgt tttcactgat tcacgcggca gcggcgattt cgtttcgcgc 2665561 cgaccagaca gtcagcggtg tcgccattaa catgctggcg cttggggcaa ctttatttat 2665621 cgtcaaactg atctacggca aagcgcagac agacaaaatt ccagagcctt tttataagac 2665681 gaaaatcccc ggtttgggcg atattcccgt cttgggaaag atcttctttt cggatgtcta 2665741 ttatacgtct attcttgcaa tagcacttgc ctttatttcc tggtttatct tgttcaaaac 2665801 gccgttcggc cttcgtatcc gttctgtcgg cgagcatccg atggcggccg atacgatggg 2665861 aatcaacgta tataaaatgc gctacatcgg cgtgatgatc agcggattgt tcggcggtct 2665921 cggcggcggc gtatatgcct ccacaattgc gcttgatttc acgcactcta ccatctccgg 2665981 gcaaggtttt atcgccctgg cagcgcttgt attcggaaaa tggcatccga tcggagcact 2666041 gggggccgcc ctgtttttcg gattcgccca aagcttaagc atcattggat cgctgctccc 2666101 tctttttaaa gacataccaa atgtgtatat gctgatggct ccttatatct taacgattct 2666161 cgctttaacc ggctttatcg ggcgggcaga tgcgccaaaa gccaatggcg tgccttatat 2666221 taaaggaaaa agataaacat tctcccctgg gaagacgatt ctcagggatt tttttctaat 2666281 ccaaaagacc cccttaattt aattgtttat tagtttttta acttaaaaaa atatgaagtg 2666341 ttaacgcttt cttgtagact gtaacaaaca atacatgggg gtgtatgaca tgggagcaat 2666401 tccaaaaacg gggacaattt cacctgagca aaaagactca caggagaaaa acctgtttca 2666461 aaaaatttgg tcttgggaaa tcggtgtgat tcctttgcca ttatacacag tattagctgt 2666521 tattattatt cttgcagcat attacaatga gctgccggca aatatgcttg gcgggtttgc 2666581 catcattatg attcttggtg tgtttctcgg agacataggc caacgcatac cgatattgaa 2666641 ggatattggc ggccctgcta ttttatcttt gtttgttcct tcatttttag tcttttacaa 2666701 tgtactgaat tcaacatctt tagacgctgt aaccaacttg atgaaaacgt ctaacttcct 2666761 ttatttctat atcgcttgcc ttgttgtggg aagtatcctc ggtatgaaca gaattgtttt 2666821 aatacagggg tttatcagaa tgttcgttcc actggttgca ggaacgatcg cggccgttgc 2666881 agccggcatc cttgtcggat ttatttttgg ctatagtgcc tatgattcct ttttctttgt 2666941 tgttgtcccg attattgccg ggggaatagg tgaagggatt ttgccgcttt caatcgccta 2667001 ttcacaaata ctgggctcat ccgccgatgt atttgtgtct cagctggtgc cagccgcaat 2667061 tataggaaac gtttttgcta tcatatgtgc agccttaatg aaaaagcttg gcgacaagcg 2667121 tccagatcta aatgggaacg gacgtctcgt aaaatctaaa aaagcaaatg agattttcaa 2667181 tcaaaaagaa gccgaagcaa aaattgattt taaactaatg ggagcaggag ttctgctcgc 2667241 gtgtacattc tttatttttg gcgggttatt ggagaaattc atcttcatcc cgggcgcgat 2667301 cttaatgatt atttcagctg cggctgtcaa gtatgcaaat attcttccga aaaaaatgga 2667361 agaaggcgct taccagcttt ataagtttat ttcttcaagc tttacatggc cgctgatggt 2667421 cggtctcggc atcctcttta ttccgttgga tgacgtagcg tctgtgattt ctataccgtt 2667481 tgtcatcatc tgtatttcag ttgttatcgc gatgattggt tctggatatt tcgtaggcaa 2667541 gctgatgaac atgtatccgg ttgaatccgc aatcgttacc tgctgccaca gcggtctcgg 2667601 cggaacgggt gatgttgcca ttttatcggc atcaggaaga atgggcctta tgccgtttgc 2667661 ccaaatttca acccgtctcg gcggtgcagg cacagttatt tgcgcgacag tgctgcttcg 2667721 ttttttcact tcataaacag aaagagttcc gttttatgcg gaactctttt tttatttatt 2667781 cacaatccga atatactctc ggggaccaaa cggcagatcc tttgattccg tctcactcat 2667841 tctggctgac aggtggtgct ccagtaaata cagctcccac tcatcacaag ccgccacacc 2667901 gctgcgcccg tcatattgat tcaacatgaa tgcccctgca aatactgagc agaataaacc 2667961 tgagcacatc acgacttttg ttttcacatg accagctcct ttccttcagc ttgatcagga 2668021 ttgattttaa atatacaaat aacctctttt ttgttagact tattttgagg tcaaaagaac 2668081 tcataaaaat ccattacagc agttcgaagc gtggcagctt gcagaaaagt gcgatataat 2668141 ttggactagg tcgtttgacc gtatatttta tacatagcgc atttttcaat tgagaacgag 2668201 aaaaggaggt cttatctttg cagctcttac atcttgctat tttatcgcct tttttatttg 2668261 cttttatcat tcccttcttg gcaaaatacg caaaaagagt gcatacgggc tggtttgtgt 2668321 tgatcctgcc cgtcttgctg tttatatact ttctcccaat gatcaggatg acgcaatctg 2668381 gagaaacact tcgatcggta ttagagtgga ttccgtcact cggcattaac tttaccgttt 2668441 atatagacgg cctcgggtta ttattcgctt tactgatcac aggcattggc tctttggtca 2668501 ctctttacag cattttttat ttatcgaaag aaaaagaaca gcttgggccc ttttatgtct 2668561 acttattgat gttcatgggc gccatgctcg gcgtcgttct agtagacaat gtcatggttc 2668621 tctacatgtt ctgggagctt acaagccttt catccttttt gctgatcggc tattggtata 2668681 agcgggaaaa gtcgcgctat ggcgcagcca aatcactttt gattacggtc agcggcgggc 2668741 tgtgcatgct cggcggattt attctccttt atttgataac ggattccttc agtattcgag 2668801 agatggttca ccaggttcaa ttaattgccg gccacgaatt gtttatcccg gctatgattc 2668861 tcattttatt aggggctttt acgaaatcgg cgcaatttcc tttttacatc tggctccctg 2668921 acgcgatgga agctccgacg cctgtcagcg cttatctcca ttcagctact atggtaaaag 2668981 ccggcattta tgtgattgcg agattcagtc ctattttcgc cttttcagct cagtggtttt 2669041 ggatcgtgtc cctcgtcggc ctctttacga tggtttgggg ttcattccat gccgtgaaac 2669101 aaactgattt aaaatcgatt ttggcgtttt caaccgtcag ccagctcggc atgatcatct 2669161 ccatgctcgg agtcagtgct gcggcccttc attacggaca tacagaatat tatacagttg 2669221 ccgctatggc tgccattttc catttgatca accacgcaac ctttaaagga agcttgttta 2669281 tggcagtcgg gattatcgat cacgaaacag gcacacggga tatccggaag ctaggcggcc 2669341 tgatggcgat tatgccgatt acttttacca tttccttaat cgggacattt tcaatggccg 2669401 gcctaccgcc gtttaacgga tttttgagta aagaaatgtt tttcacaagc atgcttcgcg 2669461 tgacacattt tgacctgttc aacgtgcaga catggggcgt tctgttccct cttttcgcct 2669521 ggatcggaag tgtatttacg tttatctaca gcatgaaatt gctgtttaaa acattcagag 2669581 gaaattacca gcctgaacag cttgaaaaac aggctcacga agcgcctgtc ggtatgctcg 2669641 ttccaccggt cattcttgtc gctttggctg tcagtctctt ctttttcccg aatatattgt 2669701 cgtacagcct gatagagcct gcgatgaact caatctatcc gacactgctt gacggccatg 2669761 agaaattcca cgttcacatt tcacagtggc atggggttac aacggaattg ctcatgactg 2669821 cgggtattgt tgtgatcgga acaattggtt atttgtcgct gaataagtgg aaaggaatct 2669881 ataaactgtt tccttcgaaa ctcacactca accggttata cgataagctt ttgactatga 2669941 tggagaaagg ctcttaccgg gtcacaaaac aatatatgac cgggttttta agagattatt 2670001 tgctgtatat cttcgctggt ttcatcattc tgataggcgg agcttttgcc attaaaggcg 2670061 gattttcatt taaaacggaa ggcatggcta aaatcggtgt atacgaaatc attttgacgc 2670121 ttgtcatgat cagcgccaca gtggcgactg tttttgctag gtcaagactg acggcgatca 2670181 ttgcactcgg tgttgtcggt tatacgcttg cattgttttt tgtcattttc agagcgccgg 2670241 acttggcatt gactcagctc gtcattgaaa cgatttctgt ggcactgttt ctgctttgct 2670301 tctaccattt gccgaaactg aggctgaaaa caaaaacgag aacgttccgg atgacgaatt 2670361 ttatcatttc tttaggcgtc ggtgttatcg ttacactgct cggcatcgca tcctcaagcc 2670421 agcggacaaa agacagcatt gcgtccttct ttgtcaaaca cagccacgat ctcggcggag 2670481 gggataatgt cgtcaatgtc attctcgttg atttcagggg atttgataca atgtttgaaa 2670541 ttacggtatt aacgatagcc gctctcggca tttacagcat gattaaaaca aaagtaaaag 2670601 aggaggggaa aagcggtgaa tgaacaaaaa acaaatgact tgattcttca aaccgcgaca 2670661 aagcttgtat cctttatcat tttgcttttc tctttctatt tatttttatc agggcataac 2670721 gcgcccggag gaggctttgt cggcggactg atcacgtcct cttccatcgt tctcttgctc 2670781 ttggcatatg atttaaaaac cgtgcgttcc cttttgcctg tcaatttcat ttatgtcgcg 2670841 ggagccggcc ttctgctcgc tgtattaaca ggcgttggct cctttgtctt cggggctcct 2670901 tttttaaccc acacattcgg atactttcag ctgccgatcc ttgggaaaac ggagctcgcc 2670961 acagcgacga tatttgattt aggcgtttat cttgttgtcg taggcataac gatgaccatt 2671021 attcaaacga ttggagagga agaataatgg aaatcttaat ggctgtatta gccggtatta 2671081 tttttatggc tgctacgtat ttgctgctgt ctaaaagcct gcttcgcgtc attatcggaa 2671141 cagcactgtt aagccatggc gttcatttaa tgcttttgac tatgggagga ttaaagaaag 2671201 gcgccgctcc gattttgagc gagcatgcca aatcatttgt cgatccgctt ccgcaagccc 2671261 tgattttgac cgcaattgtc atttcttttg gcgttacgtc attcatcctc gtcatggcct 2671321 ttcgcgctta tcaggaattg aaatcggacg atatggatca aatgagggga aatgatcaac 2671381 atgaataatt ttgttatttt gccaatcctg atcccgcttt tgtcggctat tcttctgatt 2671441 ttcatgacga agaatcttat gctcatgaga atcttcagca cggcggcatc ggccatcggg 2671501 attgtgatta gcggcatact tgtacagact gtcttcacaa aaggcatcca gacactcagc 2671561 ctaggcggat ggaaagcgcc gtacggcatt gtgcttgccg cagaccaatt cgccagcctt 2671621 ctcgttctca caacagcgat catcggttta ttggttgggc tttattcctt ccgttctgtc 2671681 ggtgaaaaac gggagcgctc cttttactac tccggcgttc agttcttgct tgccggcgtc 2671741 agcggagcgt ttttaacagg cgatttattt aatatgtacg tattttttga gcttctgctt 2671801 attgcttcct atatgctgat tgtattaggc ggcacaaaaa ttcagctgcg ggaatccctt 2671861 aaatatattg tgtttaatat tgtatcgtct gccctgtttg tcataggggt cggcttttta 2671921 tacgctgtaa ccggtacgtt aaacatggcg gatcttagcg tgaaaatcag cgaatcagga 2671981 caaaccgggc tgatcactgt gattggtgtc ctgctgcttt tggtatttgg catgaagggc 2672041 ggaatcttcc ccctctactt ttggcttcca ggctcttatt acgcgccacc ggcggcaatc 2672101 tccgcgttgt tcggcgcttt gctgacaaaa gtcgggttat atgcgattac gagggttttc 2672161 acattgattt ttattcacga tacagccttt acccatcagt tgatgatttg gctggcggcg 2672221 ctgactgtga tttttggtgt gatcggttca ctcgcttatt cgaatgtcat gaaaattgtg 2672281 atctataaca ttattaccgc tgtcggcgtg attttgttcg gtgtggcagt acacaccccc 2672341 gcatccattc agggcgcgat ctactatctg attcacgata tgctgattaa gggcgctttg 2672401 ttcatgctgg caggtacgct gatcgcattg actggaaccg cgagcctgca taaaatgggc 2672461 gggctgatca aacgctatcc tgttcttgga tggatgtttt tcatttccgc tatttctctt 2672521 gcaggcattc cgccactgag cggatttgtc ggcaaattta aaattgcaga gggcggcttc 2672581 gcagaaggtg aatttacgat atccatgctg attctgcttt cgagtctgct tgtactgtac 2672641 tctgtgctga ggatctttat acatgcgttt tggggcgaag aaaaagaaac gccaaaacca 2672701 aatcatcgaa cagctaaagg acttctttat ccggcagcta tttttctctt gctgtccctt 2672761 ctcttcggat tgggtacaga atgggtgtcg ccttacgttg atcaagcggc cgagacgctg 2672821 ctgaatccgg aaaaatatat cgaagctgtt ctgaaggagt agatcgcatg gcatttcaaa 2672881 ttttattaaa tgtgtttctc gctttttgct ggatgttctt aagcaacagt ccaagcgccg 2672941 caggattcat tacaggctat attctgggaa tgctctctct ctttttcttc cggcgctttt 2673001 tcactcgcca gttttatcta tggaaattga tttctattat caagctctgt ttcattttta 2673061 taaaggaact gtaccttgcc aatgtcagtg tgatgaaatc agtcttatct ccaaaactga 2673121 atatcagacc gggtattttt gcttttaaaa ctgaactgac gaaggactgg gaaatcacca 2673181 tgctttctct gctcattaca ttaacgccgg gaaccttggt gatggatatt tcagatgaca 2673241 gaacaatact ttatattcat gcaatggata tcgaggatgc ggaaaaagcg atttttgaca 2673301 ttcgggagtc atttgaaaaa gccatacagg aggtgagccg gtgatgttta cgctgatcct 2673361 gcaaatcgcg ctcggcatta tggcagtgtc tacctttttg tatgtcattc gtgtcattaa 2673421 aggtccgact gtgcctgacc gggtcgtggc tctggatgca atcggcatca atctgatcgc 2673481 aatcacggcg cttgtctcca ttttgctgaa aacaagtgcg tttttggata ttattttgtt 2673541 gctggggatt ttatcgttta tcggaacgat cgcattttcc aagttcctgg agaaaggaga 2673601 gattatcgaa aatgatcgaa accgctaagg tcgttgtggc tgtattcatt ttgctgggtg 2673661 ctcttatatg cctcattgct tcatttggcg tacttcgcct tcccgatgtg tttacacgcg 2673721 ctcatgctgc ttctaaaggc tcaacattag gtgtcaatat gattctgctc ggtgtcttct 2673781 tctatttgtg gtttgtgacg ggggagctct ccgctaaaat cctgcttggg attctcttta 2673841 tctttattac gtcgcctatc ggcgggcact tgatctgccg tgctgcgtat aactccggcg 2673901 tcaagcttga tgagagaagt gtgcaagatg actataacgg aatcagaaac tttgtgatta 2673961 aacgaaaaga ggattcttat ttataaaaat aagcagccgg acaggcagag ttccggctgt 2674021 ttttttattt cttgatgaca gccagcgtgc atctggatat acagatcagc ctctcttgct 2674081 cgtcatatat gtgaatatga tagacaatcg tcgttctgcc tatatgaacg ggctcggcta 2674141 tcgcctttac cgttccttcc tttacagatt ttaaatggtt ggcgttaatc tccaaaccaa 2674201 cacaagcttg cgttgtatga tcaatcaggt tctgtgcacc tgcgctcgcc gcggtttccg 2674261 ccagggccac tgaagcgcct ccatgcaaat atccgaacgg ctgtaccgtc cgatgatcca 2674321 ccggcatgac cgcaacgcat cgttccgctg tgttttcaac aatctcaata ccaagcgctt 2674381 caagcaatgt gtgcttcata tccatctcta caccccccaa catttaaagt acaccgtctg 2674441 atttcgcaat caaaaccgct tccgtccgtg aaccgacatt cagcttattg aaaatcgatg 2674501 tcaagctgta ttcaatggac cgcttgctta aatgaagggc atctgcgatt tcttggtttg 2674561 taaatccctt ttcaacttct tgaagaatca ggcattctct aggtgtgagc acatcttgtt 2674621 ctttttgaga ggaaggagcc ggctttgttt tttgctgagt catcagctgt ttaaagtaag 2674681 caaaatcgac taaaatttct ccgttgagta cgtggtatat gtattgggtg atcttttctt 2674741 tagattccgt tttgctgatg gcaccgtgca gacccgcacg aatcgcttcc tcgaaataat 2674801 cctcgacctc ataaccggta tacacgataa ttttacaatg aggattctct tgtaaaatct 2674861 gtttagaaag ctccatccca ttgacctcgc cgcctagatt cagatccatt aaaatgagat 2674921 catatgacga gaaatcatgc tgcttgataa actgttcgct cggttcagga ctgagacaat 2674981 caacagacaa attcgaatcc gtttccaaaa ttgtcttggt gccttccatg acagccggat 2675041 ggtcatcaat cactagtatc tttttcatgt tttcctccct tttactcact cttttccatt 2675101 ttataaaaaa gacttggcct gtgccaagtc gtttccgtta taaatccatt acaattcgat 2675161 ttcaatatca gccttaaagc cctttccttc acttgtttca atccgaaggc gcccatctaa 2675221 agccctgact ctctccttaa tgccagaaag ccccatgctc atggaatgct cagtattttt 2675281 ttcttgatca aacccaacgc catcgtcctc ataatgaaga acgattttgt tttgaatact 2675341 gatgagcata atcagcacat ccgtcgcctg agagtgcttg accgcattag acagaaactc 2675401 ttgaatgatc cggtacaaat tcagctgcga atccagatca agggaagccg taaatctccc 2675461 ggtatttaaa cggatatgaa acggaacccg ctcctgctgc tgcgccacca gcttcgacag 2675521 cgccttcacc aatccaagat catacagaag ctgcggccgc agctcatgac acgtctccct 2675581 cgtcatcgaa atcacatcag acatctgctc attcatctgt acaagcttgt cctgcacctc 2675641 ttcacggcac ggattatcat ccttcttgaa atcacccaaa aacagctcac actggcgttt 2675701 taaggaaatc aaatcctgaa gaaccgaatc gtggagatcg cgggcgagtc ctgaacgctg 2675761 tttttcttcg attgcaaaca ttagcttttt cagccagatg gggttggttc cctcttgttt 2675821 taagtccttc aaatgttcca tgagctcctc aatatgcagg acattttcca tggacacact 2675881 tgtataaaaa gacagtgttt tcagccacga tatttcatca cgtgttagcc ggggagtgtt 2675941 aatattagat aaacaaagca gaacataaga actaccgcct cgttcaccaa ctttcataag 2676001 aaagccttga ttgacttcta taattttccc aatttctgaa gttacgtttt caaattcctc 2676061 ttgataaaaa ttccagtccg gtccaacttc atgcttatct aaaaatatca ctttgtgatc 2676121 aggagtaacc tcaaaggtat aagctttgct tacaagcaaa acatccagta tagtattttt 2676181 cagttcttta aaaacttgtt gaagagaagt tacacccctc attagctgag tatatttaaa 2676241 aatactgtcc tgatagttga atttttcgga gaaacgtttt aaccgaaatt taaaatccat 2676301 gacctcttta aaataaaaga cagcgaacat gacaacgaaa aaaaatacag tttgacgcac 2676361 agggttcatc tggatgtcca ttacatcaaa cagaactaat gcaccaacta ttagaagagt 2676421 tggtatcatg gcaagtagag catagtatct cattcttcct aagataaact ctatatcaaa 2676481 catcttattg gctacaaatt ggtatactaa cccgaacgga attagtacta gtaatgacgc 2676541 cgaagctaat gccgggaaaa tataattacc tgtaaatatt attggaagaa caaaaaatat 2676601 caaaaaaggc gcaaatgaaa gagtgtttgt taaaattagt aatttaagaa taaacgaatg 2676661 ctcagcatat ttatatttat taagatgtaa gtatatcgct gaaaaagaaa atagagtcaa 2676721 agttgcaaaa gaaaccaaat taagagttgc taaaaaatca atatctactt gtaaatagtc 2676781 ttgaaaaaac tcaataccaa gattaaatat tggtatgata taaagaaaag aaattctatt 2676841 caaaaaagtt ttacctattt ctccaaggta tctttgtata aattgaagat aaagaatagg 2676901 agaagatata aaagtaaaca agttaatata ccgattgatt atatgtcctc taaatggtcc 2676961 gcctgcactt atatatgcta tcgaaatgtc taataacaat agaataagaa tataggcagc 2677021 aaatgatctc ctttttttat ttactttaag tatataaaaa atacatatta tgcttaaaaa 2677081 ataaaaaaac aaaggaagta cgaacagaaa aaaactataa ggtctattta gagtaactaa 2677141 atcaaaatct ttgagatgaa tcttttttcc acttctcaaa atatccagac tgttaatatg 2677201 actcaaatat ccccatttca aatgtttgtc tgaaggtttt tctttattaa tttttaatat 2677261 gatgtctccc tgtctcagac caacaaattg tccatatgaa gattccgata tttcttctat 2677321 cataaattga cttttatcat ttttatgaat cttagtccca ataataattc cattcatact 2677381 gatataagtt gtatagctta tataaaggat actcaaaaca attacagcta ttgtgaattt 2677441 ttttattaag ttcttcaata ttaatccacc tattaatcac cccattgacg ggttattgga 2677501 tcagccagat aataatcatt ataagcttta attattgttt cagtttcttg cacatcaaaa 2677561 cctataaggc aggcttcttt atttttcaat ttttttaaag cctcaggata atttaaaaag 2677621 tagttaatta ggtcttgcat cttgtatccc cctttgtata acttaataag cattccttta 2677681 ttagctcttt ttttctttat ctaaatttaa ttgttctata gcagaaatac atttctgttt 2677741 atatatttcc aataataccg aaatgtattg agtaactccc gctttaatta atttttcttg 2677801 gaatttctct ttatcaagta acgatttata atataagtct ttatgtgaaa ttaagtataa 2677861 taaatcttcc gaagcatcat taaaaaggcg cttaagatat aagtaaatca gtgtatgttt 2677921 gtttttttca atatcactgc gatttccgga taaaagaaca taataatctc cagaaatttg 2677981 agctataatc cctttatagt aggaatatct ttcaactgtt tcattatatt ctcctgtagc 2678041 caataaaaca cctgctacat ttgctagtgc aatcagactt ccacatttta atctaattac 2678101 ttctaaactt tcatcttctg ttttagattt attagtgata tcgtcatgtt gaccttgcat 2678161 ggcctcgttt acgtatttta aaacatattt aaaaattaga ggattgttat ttaatgaata 2678221 aatactcgtt aatcctactg tatacaagga aagtgctgca tttaacgact ccgagcgatt 2678281 aattttcatc cataatgcat ggtgattatc ttcatcttca agatcatcca taatatctga 2678341 tgaaagaata agaatttcta ttcccgcgcc aagccttgtt gcaacatcta aattctcccc 2678401 tccaaaaaca acataatgta agattgtgga ttcagcaaag gagaatgttt ctttagaatc 2678461 aataaatgag taaagaagtt gtgacaaatc ctcgttaaat atgttttgct ccacaatctc 2678521 cttcattttc tccttgatcc ggacagaatc taaacatatc tgctcaataa cgacttcccc 2678581 cctcccattc cattttacta aatgggacat ttaaaggaca gcaggttttt cgttttttaa 2678641 caatcatata atactttatc catttattgt atcggtagaa cgaaaaaaaa gacttgtttc 2678701 caagtctttt tcacgaaatt ttcattgcat aattgtattt atcgagttga tcaatgcttt 2678761 tgttaatgtt tcgtaatgaa tctgtcgttt ctttaatatc aagttcgagt cggaataaca 2678821 attgttttac ttcttcaagt ttcttttcca tcgtttccac actccttttt ttgaaagatc 2678881 aatgaattgt gtatggtgaa cgagtcctag gtatttgatc tgttactaat agtgtgtctg 2678941 ctttcggctc atttttcacc gaaaagtatg caaaaaagtc ctgcgtgaca ccgcaaatct 2679001 caataggtcc ttatactcaa aggaatcaca acaagaacgg gactatcttt ctatgcgaaa 2679061 gagcgtttat atgtgctgaa attgagaaag attcttaatc tccttgattt taacgggttt 2679121 cgcattttca ctaagcaaga ctatagtcct tcataccgta ttttcaaaat tgaatatgcg 2679181 attcttggcg tttcctgacc gacaaacacc gaaaaagacc gcaacgctaa agttgtggcc 2679241 ttttcgcttt gtcatattcg gcaattaggg atctatacat atagaaacat ccttttttgc 2679301 gaggtgctcc catgagatat cgttatccct ggttttacgt gtatccgtat gaggtacgcc 2679361 gtccgcccgc tcctgccaac aatattgata cctttatccg ttcagcgaag caggccgcag 2679421 ggatatttgc ggatgcccag ctcgttctca gccgcattgc gggctcgcgg gagctttcgc 2679481 gccgcattct gaccgcagcc gaacagtctg ataaacaaac tataaggcgc ctgatcaaac 2679541 aaatgggcgt ccggcatgaa gtggatacgg tctttaatcc cgacggcatc tatatcagcc 2679601 ttatcggaac gcaaagccga atgattcttg ctttgcggtg gtcagaggac cgcaatcatt 2679661 ttgcgtccat aagattatga caccattcca gagcctctaa ataacattca tacgcttctt 2679721 ctttgtccag ttgattgcct aattctgagc aagtgtccca gttgttgctt tcaattaatt 2679781 tcacaagctc aagcatttgg tagtagtcgt tttgatggcc taataatgct tgcccgactt 2679841 catcttttaa aggcaattct tgaacaattt cctctatttc tctatgcagg agggtgtcta 2679901 tgagagaaaa cattccgatc agcatataag aagcaggctg cggccgggat gtctttctcg 2679961 ccagcagttc gcaaagcttt gctcttatca gagaaatctt aatgatttcg tgcttgctgg 2680021 aatgcccttt cctgcttaaa tccttaaagg aaagaatata tatccaccgt ttgatttcat 2680081 taaatcccag cagcataatg gcctgttgaa tgctttcaat tttctggctc aaacggctgt 2680141 gggatgagtt taaaaatttt aaaatttgat aggacagtga taaatcccgc tctatgtact 2680201 ctgtcacacg ctttatgtta ggctgctctt tactcagttc gttaagcagt tcatagtaag 2680261 aatagaaatg agtcgatagg tcatgcccgc tgatgatgcg cggctcgctg aaaaagtagc 2680321 cttggaataa ttgaaagccg tcttggaccg cctgtttata ttcttttcgg gtctctactt 2680381 tttccgctaa aaaaatcagg ccgcggcagc cgtaggtttg caaaattgtt ctgcgttcca 2680441 ttcgtgttgt tttgagaaaa tcaattttca atatatcaat atagctcatg agtttttcca 2680501 gtaagtcctc atcttgcgga tttattgcat aaaaatcatc aagcgccagc atatacccca 2680561 tttttttcaa ttctttgcat ctagaaatga gggccggcgt gatcggtata tcttcaagga 2680621 tttcaatgac aagctgtttc ggattgaagg aggtgggaag attcgaaaac atcaggcttt 2680681 ccgtaaaatt aacaaaacag cgtttccctt ccgtcagctt ctcaattccg atgtttaaaa 2680741 agctgttgat caccaaatct gttgttgcct gatcgccgtc tttagcgcta tacacgttct 2680801 cttcgctttc tctatacagc agttcataag caacaacctg ttcttttcta ttaaaaatag 2680861 gctgtcttgc aacaaacacc ctcattgatt tatccccctt acaatacgcg cggctttcac 2680921 ccctaagtat atcaaataat ttgacgaaaa ttgtctaaac atgaaaaata atatatacat 2680981 aaagaaaact ggcccttcgc gaatgaaagg ccagtttttc tttattcttc ctcaagctct 2681041 tcttcaattc tgcttttcac ttcgtggatc cgctgcattt tattgctcca gcagtcctcg 2681101 cttaaatcaa ccgggtattc ctccggcttg ctgattctct tatattcctc ccaaagcagg 2681161 ctgaggttat cctgcacata ctgctgtatg tctgaaatct cagggttttg gtagcaaaga 2681221 atacccttct caaaaatcag ttcatgaaga tccttcgcat aaaaattcgt gacaaatttg 2681281 ctgatgaatg tatgaaccgg gtggaacatt ctgagccgct tctgatcatt cacctgctca 2681341 tcataaagcg caatatagtc gccttcagaa tgatggttgg actgattaat aatgcggtag 2681401 actttctttc tgcccggtgt cgtcactttt tcaggattgg acgaaatttt gatcgtgtcg 2681461 accattttcc cgtcttcttc aatggcaacg agtttataaa ctgcgccgag agccggctgg 2681521 tcataggcag tgatcagctt cgtaccgaca ccccagacat caatgcgcgc tccctgagcc 2681581 tttaaattca taatggtgtg ctcatccaaa tcgcttgaag caatcacctt cgcatctgta 2681641 aatcctgctt catcaagcat tttccgggct ttttttgaca ggtacgccaa atcgccgctg 2681701 tccagacgga tgccaatgaa attaatgcgg tcgccgaatt ccttggcaac cctaatcgcg 2681761 ttcggcatgc ctgaacgaag cgtgtcatac gtgtcaacta agaagacgca atccttatgt 2681821 gtttccgcgt attttttgaa agctgtatat tcatcgcggt aagcctgcac aagcgcatgc 2681881 gcatgtgtgc cggaaaccgg gatattaaag cgctttccgg ctcttacatt gcttgtcgcg 2681941 ctaaagccgc cgattaaggc tgctctcgct ccccacatgg ccgcatccat ttcgtgcgcc 2682001 cgtcttgttc cgaattcaag cgcaacttca tcaccgatga cgcctttaat ccgggcagcc 2682061 tttgttgcga ttaatgtttg atagttcaca atgttgagca aagctgtttc aatcagctgc 2682121 gcttctacca ggggtgcctc caccctcata atcggctcat tgttaaaaac gagttctcct 2682181 tctttcatgg agtaaagtga acctgtaaaa gataagccgc gcaaatattc aataaaatct 2682241 tcatgatacc cgagttcatc ctgtaaataa ctcaaatcgc tatccgtaaa cttgaaattt 2682301 tccaagtatt caatggcttt ttccaagccc gcaaatacgg catagccatt ttcaaacgga 2682361 agccttctga aaaacagctc aaaaatcgct ttcttttcat gaatgccgtc tctccagtac 2682421 gtttccgcca tattgatctg ataaaggtct gtatgtaatg acaggctgtc atctttaaat 2682481 ccgtactcta acactgtttt tccccttcct tactctgcca cttgcgctcc gatgctgttt 2682541 gcaaaatggg aaagagccca tgcgtgcccc tcctgattaa agctggcaac agcttgttta 2682601 tgcacaacaa tccgaaaacc tttgttgtat gcgtcaacag ctgtatgcaa cacacaaata 2682661 tctgtgcaga caccggcaag atgcagttcg ccaatctgcc gctctctgag tttgagctct 2682721 aaatcagttc ccgcaaaagc agaatatctc gttttttcca tgtagtaaac attaggttca 2682781 tgttcatgtt tctgatatag aggcaaaagc tttccgtaca gatcttttcc ttccgtgcct 2682841 tttatattat gcggaggaaa aagacgggtt tcagggtgat attgatcccc ttcatcatga 2682901 gaatctactg ctaatacgac gtaatcaccg tttgtgatga attctttagt taaattgacg 2682961 atcgcctctt caatcattct gccgggctcc ccgcaggtca attttccgtc actcgccaca 2683021 aaatcattcg tataatcaat acaaataagt gcttttttca tagccggcct ccccgccatc 2683081 agtatgagaa cattatatct tatctccagt tgtaagtgaa ttgccatgaa caaaaagaca 2683141 aacggtccgt ttgtctctta cgatttcagt actgaccgat tataaatgtc gtcctgaata 2683201 tatatcaatt cacgattcac agcgatatca gccgcaatga cgatgcctaa gggcgtatga 2683261 aactggagat cagatacaat cttgaaaggc actccgtacc ggctcgccat ttggatataa 2683321 gaagagtaag actgatactg aagctctcca ttaatcaaaa gggtgacgtt atggctgttt 2683381 ttcagctcgt gctctgcctc tttatacggt ttgcttctaa gcacctgtcc tttcgtcagt 2683441 gccaaaacga ctctttctct taaagagcct aaaaacaaat ggcgctcgtc aggctttgtc 2683501 tccaaaggcc catacattcc ttgctgcaaa tagagatcca ttttatcttc actcaaaagc 2683561 ctgtcctccc gtcttgtttg tcttcattat cacctgatca ggcaggagct aaactttcaa 2683621 gcgccgttta catttctgtt acccaatgaa tgattttttt ggccagctca ccagcagggg 2683681 tttcctctgt atgccggcgc aacgacgctt ccagccgttc aggcagagtt gctttatctt 2683741 cttcatagga aatgatcgtg ctccactcca gctgcggtac cgctacaagc gtgcgcagtt 2683801 cttttctgtt ttcatgcaga tacacgtccg tgatcattcc ggtttgcgta ttgatatttg 2683861 cttttctgat tttcataaca tgacctctct attcaaagac tacccatatt atacaataaa 2683921 aaagcaacag cctcttgtga aaaggctgtt acccgttaaa cgaaactgtt tcatcagtga 2683981 tatcggcatc tttgaagaga gttttactcg tttggttgtt aatcttcaca aaatcaccaa 2684041 gctgaaatgt gcctgacccc gcccctgaat gagcgacgct tttgggcgaa atcgcaaata 2684101 cgtctccaaa gcttgccgcg gcattatccg taactgacat gatataaatc ggccccacaa 2684161 ttgcaggcat ttccccacct ccgcattgat ttacagcatc atatgcaagg agccgataat 2684221 ggtgcccgcc tattcagctg gctttgcgtt ttcctcgagt cgtgaccgct ggcgcagctt 2684281 gatcaagcgg acaatattca ggaagaacgc cttcactacc gcataaaccg gcaccgctaa 2684341 aatcatgccg agaattccgc cgaagcttcc cgctccgatt aatagcaaaa taatcgtaag 2684401 cggatgggta ttcagccgct ttccgatcac aagaggagac agcaggtttc cgtccagctg 2684461 ctgaacgatg acgaccacaa taatcgcaaa cagcgctttg gccggcgagt ccataaaacc 2684521 gacaatgaca gccggcgcgg caccgagaaa aggcccgaca tagggaatga tattggtaat 2684581 cgccatgaca atcccaagaa tcagggcata cggcagtccg gcaattaaat agccgataaa 2684641 acacgctgtt ccgacaaaaa gacagattaa cagctgcccc tggaaatatg ccgcaagcgt 2684701 atcggataaa tctttaaaaa tctttaagcc ttctgtccga taagaagccg gtagaatttt 2684761 tactgccaaa tgcggaaagc ggtgtccgtc tttcagcatg taaaaaagga taaatggaac 2684821 agtaataata acaagcgtga tgtttgtcac gacaccaaac accgcagata aactggacgt 2684881 gatattttgc ggcaggtttt ggagaaaact tgtcaatgac tgttcaattt ttgatatcga 2684941 tacataatcc tggttcatca tccaggtaaa ccattgagaa tgggacaaat cctttgtcag 2685001 cgcctgaatc tgttttatat aatcaggaag gttgttaaac agccctgtca cctgtgcggt 2685061 gatgataggt ccgactgacg ctgaaataaa ggcaagcaaa ccgataaaca gtaaatagat 2685121 caatagaatg gataatgtcc gcggaatttt tttctcaagc aggcggacga ccggattaaa 2685181 tatgaaatac aaaattcccg caattagcat cgggaaaaac aatgtcgaga taaaaacaat 2685241 aaacggctga aatacaaatg aaacttttgt tgctacaaaa ataatcagca aaacaaataa 2685301 aatctgcaat gtccaaaaat ggacttttga tttcaacaag ctttgttcct cctagttttt 2685361 ctttgtctgt cagataaaag aacttatacc ccatcattgt aacaaaaatg aactcatatc 2685421 agaactctta atataatgaa aggagtgttg gtgatgaagg ccgtgacata cgatacagat 2685481 tcagaactgg cttatatcta tgttcttcct ccgaaaaaga acaggaatgt acggactgag 2685541 gagctcagag tcaatgattg tctcctgctg gatatcagcc aagatggcaa aatcgccgga 2685601 ttcgaatgtt ttggtgaggc agcacacctc tgtgccccat ttgccgggaa atcccggctg 2685661 tatgtaaaag attcagacgg ttatcatttt cgggtctgcc agcatgcttc agtccgttcc 2685721 tgctatacgg tgtaccgtgt cactttctgt ttttcagatg gtgactatca ggaatttgcc 2685781 ggctttgacc ttgatggaac aatgtatcat agtgcgtttt tacagcgctt aactgaaaaa 2685841 taggacgtcc tgttgtacgc ctatttttca tgcgcaagca ctgttagacc cgctcactgt 2685901 aatctggggt gacggaaatc atgtgctgga ttctgatcaa acaaacagaa tttcgggctc 2685961 cttcaattgt gatatggtca ggttttacat cgatcagtct gcctctgacc gtatctcgta 2686021 ctgtctgtat aacgaacctt gagccgatga gctttttaat ggtctgatag acataaggat 2686081 cgactaaaga gaccagttgc ggactacctt ggttgaccat acttttatcc cctttgtgtg 2686141 ttttatctca gcttatgccg cgcttatgga taatgacaca ggcttacctg ataaaacaaa 2686201 ggggtgcgga gattttagga gaatacgttt ggaggcgggt gtaaaggaag tatcgatgaa 2686261 gcggagacag cgaagaaagc tggcgctgtt ccgtacttat acaggcttta tcacggatgc 2686321 ctgggcttgg tcgattaatt ggtccagctt ttctattttt tttcgtgcgg ttgaaggatc 2686381 aatttggcgg taatgatggt ggccgcccgg ctcttcatcc agttcgtccg cttttttgac 2686441 aatctgctgc agtgtgtttt tatctaattc gccttcaggc aaataggaat ctgtatgaag 2686501 caaaatggct agtgcaatct cttttgctgc tttcggttcc tcgccaagcc gaatcagaag 2686561 tttatgcgcc cgttccgccc ctttaatggc atgaatgtca tttcttttgt atttctcata 2686621 atcccacttt ccgtctgtat accattcata atggccaatg tcatgaagca gtgccgcttt 2686681 tgctgctaaa tcaggattaa tgtcagcctt cacagacagc ctgtatgcat gataagcgca 2686741 ggcaatcgca tgtgccacgc cggaacgctg aagatatttt tgtgcaattg gatgggtgaa 2686801 aacatccatt aatgtaacct ttctcatgga aacccctcct ttagatattt ttagaatcct 2686861 aacataattt gcagagaaac tcaattctta tgtcacatca ttttgatctt cttatcatca 2686921 ttgttatacc ctaaaagcaa cgtttcagtc agtatatgcg gctgttcaat aaaatgcgct 2686981 ggctgcagcc ttttgtataa aaaaaagagc agaaaatatc tgctctacaa aaactcttta 2687041 atatcataaa tgcggccgtt ttccgtccct ttttctagta aagaaagcag cgtgccggca 2687101 ataaagtccg gactgcgaag gcttcctgtt tcatttaatt tccggaatcg ttcaatgtgg 2687161 tggaaatcct ttttcgatga agaacggatg acggcctgca tctcagtgtc catcactcca 2687221 ggtgagaacg aaatcatgtt caccggcagc tcttcatcct cctgttcaaa tccgaatgtc 2687281 ctcgtaaaca tgtcgagccc ggcttttgaa ctgcaatacg cgctccatcc cttatatgga 2687341 tttttggcgg ctcctgaagt aatgttgaca accgtctttt tgccgctgta tgaagcaaac 2687401 cgttttgtaa acagctgact caaaagcacg ggcgcagtca ggttcagctg ataatggcgc 2687461 tgaagctcgt caagagacgc ttcgccggca cgtttgatcg gcgttaccat tccggcgtta 2687521 ttaataaggg taataccaga ataacgatct gaatcgatgg atgagagcaa tgtttcaaat 2687581 tgctgttcag cttcttcgag attgatgagg tctatttgat gctgcgttag ttttttgtga 2687641 gagacatctg ttttcgttct ggataaggca tggacttcat gccccttttc taaagcctgt 2687701 aatgcaatgg cttgacccag cccttttgac gctccggtga tgatataaag ttccattgga 2687761 aacctccttt tccgttatta ttgtacggca cctcttttac acaacacaag cacgcggcct 2687821 acgccttctt gttttcctgc gctgtgactt ttgggatgag gaacacgatg cctgcaattc 2687881 cgagcaggat cagtacgaca tagatcatcg gcagcagcaa tgatgatgtt tcttgttcat 2687941 cttctgtttc cgttgatgat gtctttgtca ttggtttttc agcaaaagta attccaagct 2688001 gtttcgactg ggccgcaatc gtgttggaat cctcggcatt tgttgatgta aacaaatctt 2688061 ttatcagctc ggcgtccttg tccttcggtt tatcaaaagt gatatccttt tgttcctcag 2688121 gcagttctgt tttttcttca tagtaggtat cttcatgcaa ataattcgta tcgatttcga 2688181 tgtctttttt ctcatactgg tttggcgcga catctgtatt ttcttcagtt tgggcagccg 2688241 ctgcagaggg tatgaaaagg gaaaaggaga gcatacaaat catgatcccc ttttccatgc 2688301 tgcgatcacg cttcatacgt ttcatcgctt tctgctgtgt gttcagccat caaccggata 2688361 atcagcggca gagccacggc aatcaccgta atgatcagca gaactgttat tcccattgta 2688421 aacaagtgcc cagtaccgta ctggatgtcg atatatactt tcgaaaccgg atcttcaaat 2688481 gtaaagttcg gcatgatcaa atcaataagc ggtgcgacat agaataggat cattgctgct 2688541 gaagcaaccc agccagggat tgatccgaat ctgaatgccg tccggatgaa ggcagagctt 2688601 gcgaccagca atagaatcgt aaacaccgac cacttaatcg tctgatcgtc cggcagtgaa 2688661 taaatattca agccgaacaa gctgatcata agtccgacaa ggatattcag aattccgaat 2688721 aacgctcctt tgacgagaag cggtgcgttt tggtaatacg agctgaaata gccgattaac 2688781 agactgctga tcaacacaat gacaaggatg acaaccggag gtaccgtctg aattttttct 2688841 tccggaacct ctccgctgat tttaagcgga ttcgctaagt aatcatatac atagccattg 2688901 ttttgcccgt ctactaatgt atttccgagt atgccgtata cgtcatttcg cacgagtttc 2688961 gtggaggcga catttttccc ccagttgttg tttaaggtgt cggctttcgc ttgaacatca 2689021 ttaacgcttt gctgcatgtt ggttgtgtaa tcaatgatgc cggactggcg atcagacaat 2689081 gaacccatca tgtctgacat ttgcagcact tcctggccga ccgtatcttg gacactcagt 2689141 gccatggtac cagacagccc atcgttgctg aacgtcgcag attcctgtgt tgcgcccgtt 2689201 acaagctgtt ctgacgcttt tgcggcactt tcagagattt tcgtcagttc gtcgagaaca 2689261 cctgcttgag agtcacggat atagccgctg tagtcgtccg caaatttggt catgccgtcg 2689321 atgaagctgt taatatcctc atctgtttgc atcgtgttgt ttttgagagc ttcccagctg 2689381 gctgattctt caggtgtgag agccaggact gattggacgt tgccatcttg ctcttggatg 2689441 acttcacctt taataatagt caaagagcct agatccagat tatcatttag cgtagactta 2689501 tataaattta aagagttgta atacttcatc aagttagaaa tattatcagt ttcaattcta 2689561 cttgaaaaaa ttgaacttag tttttctttc tgatctatat agcctctact ctgcaaagtt 2689621 tgtattattt cgtcttccaa attgtatatt aacctataag catcattgac attattatca 2689681 aaatcaacca acttttttgt taagtcacca atttgatcat ttaattttga aactgtttta 2689741 tttaactctt taatttcttg atttaactca tcaatatgtt tctctagttt gttgttatgt 2689801 tcctcttgtt tttcttgaag tgcattttct atttcctcta attttatcgc tgcttcgttc 2689861 agacgttttt ttgcacctga aatatcagtt tcaccgtcag ctccgtcacc ctgtagccca 2689921 tcactttgat ttgagccatc gttttcatct gcgagttcaa tcaaagagaa atctgtttta 2689981 gaggttcctg tattctccgt gtttgtatct tgttcaggaa cgttttttga agattcttga 2690041 tgtttttgtc ccgtttcaat gttagtttga acatcatttt gtgatccatt atcttgagta 2690101 ccctcttctg atgagccagt atcttcattt gttggctgat catcggatgt tggaatatca 2690161 ttcgacggtt cttcagtatt aggagaatca tcggttgatg gttcttcagc atcgggtgtt 2690221 gttggttttt cttgttcagg ttcttttaac ccttcagaga tatctttaat ttcagttgca 2690281 acatttttga gctcatcccg ctgcttctct aaatccaatt ttatatcttc aatatcttcc 2690341 ttatctgtgt catctttatt atcagatgtg tcttctccat cttccttttc gtcgctttcc 2690401 ttaggtttaa gtaaactaag gcggttcttc ccgatattct cttgcaattg atttaaattt 2690461 tgatatttaa tagcttcata ttgactttta tatcgagata gaaatgcatt aaacatgtca 2690521 ttctcaattt ttttcatacc catttcttgc aatggcactt gattttgcct taacttttca 2690581 gcattgttca acgcaaggtt tgtcagtcct atttgtgtct tcgcttggcc gatcccggtt 2690641 gccaatccgc tcatgcgttc gctgaactga ttcgcctttt gctgtgcctg gatggcatcc 2690701 agacctgtcc ggatttgctg ctgtgttgaa tcctgggctg ccaaaagcag ctttttctga 2690761 ttctcttgat attctttgta cctttcaact gtatcaatga attctttcag cgtgtttttg 2690821 gcttcctccg ccgtagaagc tttttctttt gtcgtgcctt gcgcttcatt cattgatttc 2690881 ttcagctcat cgattaagtc tttttgctgt ttgatttcac ctgctaaatc attagagctt 2690941 ggtttgtaaa agttgtacat gacattctgg aattcagatt ctttattgac gatcttgtca 2691001 aattctcctc tgatgttgtc cactttttgc gaaacaaaat tccagtataa ggccgacatt 2691061 tttttgttca ttgtcttttg ggcatcctca agctcacgct gaactttttc tttgttaacc 2691121 gcattcaggt tatcttgaat gctgaattcg agcgttgcct tttgaggatg gtctttgtca 2691181 tagctcaaaa tgttttttga gaagtctgag ggaatgtaga caatcgcatc gtatttcttt 2691241 gaagcgagac cggtctcggc cgcgcttcgg tttacgaccg tccacgaata atcaggacgt 2691301 tcacccagaa cggccgctac ttccttgccg aactgggcgg atttgtcctc ttcatcagac 2691361 tttacctcat cactcaatac gcctgtgtct tcattcacca ccgcgatttg ccgggtagaa 2691421 ttgactgctt ttttcgttgg gtcgtctccg ataaatcgga aaaacaacac cggcagcagc 2691481 aaaatgatga tgacggcgga tattaacttg atcaagcttt ttcgttgttc tgtcatctag 2691541 cactctccct ttcagcagaa cataaaggaa tttgaacttt ttgctccttc ccgttttcca 2691601 caacatatcc gaagcccggc tgaatctcag gctcctgtct ttggtacggg agaggaatga 2691661 cattttgctc agactttttc atcagcagaa tcgcgtggcg gatttgcttc atctcagtcg 2691721 tcaaggagtc atagcctttt gagaattcgc tgtggtttcc gcccgggata aagctgaacc 2691781 caagatgagc gtatgatttc atgaagttag cgagacgatc ttgtattctc gtatcaatcg 2691841 tctgctggaa tctcgttatc ccgtcaatca tcagcacgac ttgtgagaat cgcagatttt 2691901 gtgcgtctcc ttggcggacg gcttctacat acatggcttc tcttgttttg aaaatgtctt 2691961 ctgctgtttc aatccactgc tcaatatctt ctttcgtttc caaatatgaa acatctgatt 2692021 ccttcgcata atgagataag ccgcggtcaa tcgagtcaaa caggccgatc atttcggttt 2692081 catcatcaat cagatgttca agcatgactt ttaggacgtt tgttttcccg cgctgagttt 2692141 ggcctaaaat caggcagtgc ttatgcttgc ccaaatcaaa atagactggg ctgactgttt 2692201 cttcatgaag cccgatcggt acagataaag gcttgcgttc cagcttgaag cggatagaca 2692261 attctctcgt cgacaagctc tcaggcagca tcggaatcgg tgccggctgc tccattgaag 2692321 caaatcgccc ttgaagtttc tgtacgtctg atttcagctc gttgaacatg ccgatatcat 2692381 catcggcgtc aacaggcagg aacatttgcg cgaaataaag ctcttccttt tgaatgatga 2692441 cgcgtcccgg aatcggctca agattgaatt tcggacggcc gtaaatggaa tatccttctg 2692501 attgatccat gagataatgg acaatctttg ttttcaagtt atttaacaat gactggcgga 2692561 cagcattcac ccgcgttgct gtcagcataa agtagatacc caagctttgt ccgtctctgg 2692621 aaagctggac aaattccgat tcaagctcat gcatctcatc cttgacaatg tcaaagttgt 2692681 caatggtgat aaaaatgaat ggaagctctt cttcgctcag cgcattgtac attttgatgt 2692741 ggctgatttc tttttcccgg aacaaacgtt tacggcggtc aatttcttct ttgatgcgaa 2692801 tcatgaactt ttcaattttc cttgactggt ccatcaggaa gtaatccgcg gtatgcggga 2692861 gcttcgctaa tggcagcagc gttccgtttc cgaaatcaaa gatatagaca tgaagctctt 2692921 caggtgtgta tacgtccgca aaactcatca ggaacgttgc ggctgcaatc gattttccgt 2692981 agcccgaaga gccgaagatg ccgatatttc catcttccat catcttataa gcaattggcg 2693041 cctgtctttg cagatcaggt tcatcgacat acgcaaagtg gaaatggtct ttttcgtttg 2693101 aagggaaaag agtgcgcgga atacgttccg caagcggcgg cagccaaggg cttggcagct 2693161 tctcgattcc catttcatct tggatgcgtt caatttcgtc aactacagct tcgatttcgg 2693221 tttgaacgtc ttttttcgcg ttatcttcgg tatcaacctc agaaagcggg atcagacccg 2693281 tatctgtgac gatcgcgatt tcatcctcgg taccgtagac ttcctctaag taaggcgccc 2693341 cgctccatgc agattggaac agctcataca cttcattgtt tccgacctgc aaatagccgc 2693401 ggcctgttac ggtaatgttt gcggcatcgc tgtttttcaa aatttcttta ctgtcggtgg 2693461 catcctggac cttgagcgct actttaaagc gcgagttact ccagatctgg tcgtcgatga 2693521 tgccgcctgg cttctgtgtc gccaaaatca aatgaacgcc gaggcttcgt ccgatacgcg 2693581 cggcactgac aagctccctg ataaaatcag gctcctcgct tttcagctcg gcaaactcat 2693641 cagaaattaa gaacaagtga ggcatcgcca cttctgcttt cccttgcttg tatagctttg 2693701 tatagtcatt gatgtgattg acttgatact ggtcaaacag gcgctgcctt ttttttagct 2693761 cgcttttaat ggaagcaagc gcacgcatac tgaagttttt gcttccttca atatttgtga 2693821 tcgtgccgag gaggtgggga atgttacgga acggctgcgc cattcctccg cctttatagt 2693881 caattagtaa gaaagccgct tcatgcggat gaaaatgcac tgcaagtgac aagatgtagg 2693941 tctggagaaa ttcacttttc cctgatcccg ttgtccccgc aagcaagccg tgcggaccgt 2694001 gtgctttttc gtgaaggttc agatacacaa tgtcatcttt ccctttatag ccgatcggca 2694061 ctgacagcga cttcgacgat tcacttgtca gccatctttg ctgaatgccg atttctttta 2694121 cttccttcgc atgaaaaagc tccaggaacg ataccgtttc cggaatggaa ttcgtaatgc 2694181 cgacctggtg gttcagcgtc cgcagtgtgc gtgaaaaccg ttcgttatcc tcacgctgat 2694241 gatgatcgag acggaacgga attcttaccg cttttttctt ttgtattaaa atgtcgcctt 2694301 catgctcatt aatgtagcgg acaagagttg taatgttttc cgacaagctt tcctttgttt 2694361 ctgcagcgac aattgtcgag atgcccagat gctcatgctg cccttctaaa tattcgagaa 2694421 tgacatgctc agagatcagc tgctgattcg tgatgacaaa tacaaaatgc ggtttgaact 2694481 gcagtttttc tttgtcatct tcgagatcac gctctctgat caattcgtaa agtgaagaca 2694541 ggagctgatc tcgggtttgc tcattataaa taaatccttt tgcataaata tggggcattt 2694601 gaaattgcgg aagccacttc atccactccc agtctttata ctcttcttca tgaaaaataa 2694661 atacgaaacg caaatcgtga tagctgttaa agaacgacag ctgtccgatt agctggtgaa 2694721 tctcattttt cacaatttgt gatttaccga caagccccat cggaccttct gccaaatcga 2694781 ccgtcaccgg cgcattacgg atatctttat agacgcgttg catgtgctgc gatttctcca 2694841 tgaggtcatc gatatcacga ttcgccaagt ctccgccact catattgatt tcatagcttg 2694901 acggaactgt tcccgtccca agccgcagct ggagataatc cttgctttca agtgattttt 2694961 cccagatccg gtcactgatt tcacttgtta agtatttcat ttgttcaaat gaaggaaagt 2695021 gaaattcaag aacctgcttt tgcttttcag caagtgcctg aagctctttc cgcttattgt 2695081 ctaagtaaag cttatataca cgctcccgtt tttcctcgcg ttttttccgc tggtttttat 2695141 cacggaaata ttgcactgtc gaggtaatga gagtcatcat aaacatcgcc aaagaaacga 2695201 gtataaatat gccgcgcggc tggatgatgg caactacgcc catcacgatc agcatcacaa 2695261 gcggaggcag gatgacgagc cacagccctc tgttggtttg atcgctctcc tgagagggaa 2695321 aactgaaaga aacgcggtca tccggcagat cgtataccat ccgcggcgtt cttctgtact 2695381 gcggatattt tttctgcatc tctgtactcg gtttgaccgt ttctgttaac gctgtttcaa 2695441 actgggcata atgaacaatt tctaaaaggt cttgttccgt caccctcatt tgcgtgaagt 2695501 tccagaatat ttcatccccc ggcttgagcg gcgtattggc gttgattttc tctccgttca 2695561 agaagatcgt tccgctttca gggcggaccg accagctgcc gcctgcacgg agcaaagaaa 2695621 acgtgctttg ttctgcaaat gcaaaatctt gcggattcag ataaatatct gcattcgttt 2695681 tttctgagga acatacaatt tcatcccgat ttcccgtaaa ataaacggat ttctcaggtt 2695741 cactgcccgt caatatcaag cgtatatcct gctgatccgt ttggagagta aatgatatat 2695801 ccgtctcaat cgtgccgaga caatcatttc ccaggaaaac ttcgtattgg ccgccggatt 2695861 cctttctttt aagagaaatc actccgctat taaatggaat ggtgctgatc gtaacagaat 2695921 ccttcacatc aggccctatg gtcaccggat gagacgacgg gaggttagac agatttaatt 2695981 tttgaacgtt attttggtaa aaaacccata atagactcaa atggcgaacc cccttacggc 2696041 cgaatggcag catgcgatga cctgcgcttc atgtctcacg ttatttgtca tcttttttct 2696101 catctttctt ttctgtttct tttttctcgt cttctttttc cttctgttct tcttttttcg 2696161 ctttttcctc ggctgcggct ttttcttctg ccgctttctc ttctgcttgt ttttcttcgt 2696221 ctgtttgtgt ctgttcttcg cttgtatcga ctaacgatgt ttcagaatta gactgtttat 2696281 tttcttgacg ttctttttgg gctttttcaa gctcactatt tactgaatca agttcttttt 2696341 gtatgtcttc atcatttgta tcctcagata aaagctgctg tttatattta gctagggcaa 2696401 agtaaatata atcattgtat tccagcttac ggccgatact gatcgcttct ttgtattctc 2696461 ctcgaccata atcaatccaa tataagaaat gctgagggtc tgattgaagg gtgactaaat 2696521 tattttctat atttttggtt tttgcactcc ccaggttttc gacctcaaca taggacgtcg 2696581 ccagctgata ctgcaccgat tcaggcaggc tttccgcatc gtacttggac agtgtgctga 2696641 tgacttcact gtactgcttg tttaagaacg cacggttgct gtccactatc gcctggtgct 2696701 ttggctgcgc gaaaaataag gcgtacatcg aataaataag tgccggtaca agcaaaacaa 2696761 tgagccccag gccgatatat cgctggatgt tccacttctt tctcgggata tgtatgtatg 2696821 tttttgcttt ggcttcgagc tcatcaatat gggtttgaat cagctcgagc aaatcatcat 2696881 aggattcagc atctaatatc gcctttgcct ctgcggagaa cgtcagcgtt tcattgaatt 2696941 tcaggtagtc ttcaaacgca aaagcgccgt caactgccaa agccgctgcc gctttcagct 2697001 cctgccatac tctttcctca tcacgctcgt aaggaggaat gctttctttt actccataat 2697061 ggagaaaata aggcgtaagc cctttatcga atacaatgtt ttcaggagcg acaatcaaat 2697121 tcagcctcga cagattgtgc tgctgtacgg cttgaacaag ctgataggca aactgccatt 2697181 tacttttttt atccttagct ttcatgaagc ggaatgcttt ataggaggag ggaggttgga 2697241 ttgtgatgat tacttcatca tccgtcacat cgatttcttt atgaaaaaat ggatttatat 2697301 ctttgatcac gttagcttca agaccgtcga gaagctttat tttttcccgt tgaaaggtaa 2697361 atgtatagcc ggcatctgtt ttctcggcaa cagcttctaa ttggttttct aaatatgatt 2697421 tttgttcacc tgacattcaa ccagatcctt tcataatatt tcaagccggt ctccgtttgt 2697481 aatgccgcaa tcagacagct tgcattctcc ggaaaacacc ttatccttgt tcaccactct 2697541 gatccagtgc ccttcgcgcg gaggcataga tacgctttgg gcctgccaag caatatcaat 2697601 tacttttttc accgggtggt aatctgacaa tctgagatca aagacactgc cgttataatg 2697661 tttcaaatct attgtaatat caatatacat ttaggatcac ccttacatag aaagagcgcc 2697721 gtcttctttt gaatcaggcg ctccttccct ttcatactgt tatccgcgga tttgatttgc 2697781 gatgtcttgg tcagtagact caagtgtatt tgctgtttga tcaagctgct gattcacatc 2697841 ttgaagcaaa tctgacattt tgataaatga aggtttgagc tgctcgtatt gatctgcgaa 2697901 cgcttcgctt gaagcacctt cccacatgct tttcaaatca gagatcattc ggtttaaacg 2697961 atcaacctga tttaatactt cttggctttc aacgccgtat tgcttcgcca tcgctcttag 2698021 ctcttcgggt gtgacacgaa ttaatcctgc catattcctc attacctcct gtgccatcag 2698081 cctaaatatg ggctaattca cttattttta gaacgtcatt attataaaaa cagtttttcg 2698141 gcatagtcaa acaaatatgt tttaatttta caaaatgagt ccaatggttt accccgaatc 2698201 actcaaaaat gacatatact gtaaagtaaa taggtttatt ttcttaatct tctcttcatt 2698261 ctccgaataa tccaaaagac ccaaataact ctccaactcc caaaaaaaac ctttcagaaa 2698321 atttgatgct acagcaccat ttctgaaagg ttcagttttt tctttcctta attagtcttg 2698381 cctccgatga ctttcttaga agattaatag gataagctgt cgtattatat gagacataca 2698441 ctgtcctgca aaaaggcgat tacaccgcca aatgtatata gaacgtttct ctcatgaaat 2698501 tgtttttttg cttctgttct ttgttgttga ttttcacaaa caacaacaat cataataaaa 2698561 ggaaggggat gagatgtcaa agagaaatca agcacgaaaa gtagggagat ttatgaccat 2698621 gccgaatgat ccgtttaaat atagttttga cagacttgaa gatgtggctg atcatatcag 2698681 cgacgttctg cggtgcccga tcaccataga ggatgttaac cacaagctgc ttgcctacag 2698741 tacacacagc gactgcacag accctgcccg gacgtctacc attattggca gaagggtacc 2698801 ggagaaggtg attaacaagc tgtggaaaga cgggacaatt cctgctctct taaaaacgga 2698861 ccagccgatc agagtcaagc aaatcgatga agtcgggctg agcaatcgcg tcgctatttc 2698921 gatttggaaa aacaagcaag tacttggctt catatgggcg cttgagatcc aaaaaacatt 2698981 gtccgatgaa gatctgctga cattgcaaat ggcagcaaaa gcagtgaaaa acaagcttct 2699041 caaacttcaa atcagaaaaa cgaaaaatga agaacgcagc caagaatttt tctggaaaat 2699101 gctgaccgga cacatccatc aggaggatga tatggcggat gggttccata agcttggaat 2699161 ggccgctcct tcagagtttt ccgttatgat catccgcata aatggcgagc tgactgaaaa 2699221 aatcgaacag cagctgcaat atttacagga aacgacccag caggtttacg tgctgctggc 2699281 gaccgtagat tccaatgaac ttattatatt aacctcaccc aaaacagatc atccttttca 2699341 agatttaaaa cagtttgctt taagtacgca aaaacagctg aaggagcggt ataaaataga 2699401 agacgtttct atcgcttttg gcggaatata caactctatt tcttttgtct cccgctccta 2699461 tcaggaagca ttgtccgtct taaaaacgaa ggaacggttc gctgaagaga ccaaacatct 2699521 tttcagcttt tctgagttag gcatttatca atacttagat gtcttaaatg aaaaacggaa 2699581 acaggcgggc cattataatt actcgctttc caaactggaa caatatgacc gggatcacca 2699641 gtcaaatatg gtagagacgc tagagcgctt tattgaagcg gacagcaacg tgaataccgc 2699701 ttccaagctg ttaaatatac acgttaatac gttgaattac cgactcaagc ggatcagcca 2699761 gatcgctgaa attgatttga aaaatgtgaa tcaaaaattc accatctatt tagatatcaa 2699821 acttcggcac atggatttgt gaaatttcac aaatccatgt ttttttattt tcttaatcaa 2699881 acaaagaatt ttccaaaata tcaagctaca ctaaaaatat cacatataca ggaggagaca 2699941 gatatgatca taggggttcc taaagagata aaaaacaatg aaaaccgtgt cgcattaaca 2700001 cccgggggcg tttctcagct catttcaaac ggccaccggg tgctggttga aacaggcgcg 2700061 ggccttggaa gcggatttga aaatgaagcc tatgagtcag caggagcgga aatcattgct 2700121 gatccgaagc aggtctggga cgccgaaatg gtcatgaaag taaaagaacc gctgccggaa 2700181 gaatatgttt attttcgcaa aggacttgtg ctgtttacgt accttcattt agcagctgag 2700241 cctgagcttg cacaggcctt gaaggataaa ggagtaactg ccatcgcata tgaaacggtc 2700301 agtgaaggcc ggacattgcc tcttctgacg ccaatgtcag aggttgcggg cagaatggca 2700361 gcgcaaatcg gcgctcaatt cttagaaaag cctaaaggcg gaaaaggcat tctgcttgcc 2700421 ggggtgcctg gcgtttcccg cggaaaagta acaattatcg gaggaggcgt tgtcgggaca 2700481 aacgcggcga aaatggctgt cggcctcggt gcagatgtga cgatcattga cttaaacgca 2700541 gaccgcttgc gccagcttga tgacatcttc ggccatcaga ttaaaacgtt aatttctaat 2700601 ccggtcaata ttgctgatgc tgtggcggaa gcggatctcc tcatttgcgc ggtattaatt 2700661 ccgggtgcta aagctccgac tcttgtcact gaggaaatgg taaaacaaat gaaacccggt 2700721 tcagttattg ttgatgtagc gatcgaccaa ggcggcatcg tcgaaactgt cgaccatatc 2700781 acaacacatg atcagccaac atatgaaaaa cacggggttg tgcattatgc tgtagcgaac 2700841 atgccaggcg cagtccctcg tacatcaaca atcgccctga ctaacgttac tgttccatac 2700901 gcgctgcaaa tcgcgaacaa aggggcagta aaagcgctcg cagacaatac ggcactgaga 2700961 gcgggtttaa acaccgcaaa cggacacgtg acctatgaag ctgtagcaag agatctaggc 2701021 tatgagtatg ttcctgccga gaaagcttta caggatgaat catctgtggc gggtgcttaa 2701081 ttcacaataa gcttgcagaa agatttctgc aggctttttt attttttaaa aggaaaaaag 2701141 agaccatttc acgaattatg actatgaagt tgatcataaa ggaggattca tatggctgtt 2701201 cagcaatatg gcgtgttaaa aggcatagta ttagacatga agcgggaaac agatgatgac 2701261 agtcctcatt tccaagtcaa aatgctcggt gaagagaata cgtattacag gtgcgccatc 2701321 aatgtgatgt ccagttctga ggaatctgaa gtattgtatt tggctgacga tcagtttgat 2701381 tcgggctcaa ttaccatcct tccgaacatg ccgtatggat atacaaggat caatgaagca 2701441 aaccgtgaag tggcactgga ttatgtgcgg ggcaatttgt ttgacccgcg ggaaatgaag 2701501 cctttgcctc atgaaatcac gggacctgat aatgatttaa atgattttat tgaaacctat 2701561 atgaagaaag cacaagatga gaaaacgccg gtttatatat tcggttcaaa attcggccct 2701621 gaacaggctg cagataaaat attcggcttt accccgacta acggaatgca caatatccat 2701681 atgaatcaag ggaatgcaat ggatacccgc tggaaaaaag acaacggctc ttggcatgac 2701741 gggggtattc tgattcagtt tgcagatcag tgggccgctg tgtttttagc gtttttatcc 2701801 caatcttggt gtaccgatga aaacggaaac cctgtcagag attgtgatca tacccaaacg 2701861 tctgcgtaag atagaaaaag agactgcggc aagcagtctc tttttgataa gattacacat 2701921 tttcaacagt ctttaggctg tttggcctca tatcgctcca atgcgattgg atatagtcca 2701981 aacaagcttc acgccctttt tgctcatgaa cgactgtcca gccgctcggc acatctataa 2702041 aacccggcca tagggaatat tggccttctt cattgaccag caccaaatat gtgccatccg 2702101 cattttcaaa aggatttgcc attctatttc tcctccctta tttattcaac tcttccaatt 2702161 tgacagcgag aaccttgccg atttgagcca gaggttcagg ctgacataaa tctttatgac 2702221 ggcagtcgat gtcgatttgt tcaatctgtc cgttaatata aggcttccac gagtcaggtt 2702281 caatcgggtc aaaccattca ggaatgattg ttgatctgaa aaacaaaaca tttccgcgga 2702341 aggttttcgg cttataggaa cctaaaatgc cgacagaatt tacatacgta ttcttcaaat 2702401 ttaaaatgac cgtttcatcc aggctcgcaa gcgcactgcc gtcacggcga agaatctcaa 2702461 tcgccgcttc aaaatctagc ggtttttccc ctaagctgtc tggatcatac ccgcctaacg 2702521 ccagaagggc aataagcgct tcctcatcat ccggtgcctc ttttatagga aggaagtggt 2702581 tcggataggc gtccagcatc accaacaggg atacttcttc tccttgattt tgcagctggg 2702641 tagccatcgc ttgaacgaca ttcccgccca gggaccagcc cagcagatgg tacgggcctt 2702701 ttggctggac cgttcggatt tgtttaatgt aatcggcagc catgtcatca agtgttttcg 2702761 gaagctcctc gcgctgcccg attccccgtg cctgcaagcc gtagatcgga taatctgttc 2702821 ctatattggt catcaaaccg gcataacacc agctgagccc ccctgccgga tgaacacaga 2702881 ataaaggagg cttgtctccg cttgttcgga gcggcagcag aacgtcaaga gcgctttggc 2702941 ttgatcccat ttcaagtctt tcagcgagcc cggctacagt aggtgcttcg aacaagttgc 2703001 cgatgctgag ttcaacgccg agcgcttcac gaatgcggct catgagctgt acagcaagca 2703061 aggaatgtcc gcctaaatca aagaaacggt catcaatgcc gacacgcggc aagtgaagca 2703121 cctccataaa gaggtcacag agaatttctt cctgcggcgt tctcggtcct cgtcctgtca 2703181 ctgccgctgc gaaatccgga gcgggcagcg ctttacgatc aagctttcca ttcggtgtca 2703241 gcggcaattc tttcatcgtc acaaaggcag caggcaccat gtaatccggc agtctctcag 2703301 cagcatatct gcgcagttcc gccgtatcaa atgtttcttc cgaagggatg acataagctg 2703361 ctaaccgttt atctcccggc tgatcctcac gaacgatcac tgccgcatct tcaagctgcg 2703421 gatgctgaac aagcgcggct tcaatttctc ccaattcaat ccggaatccc cgaattttca 2703481 cttgatggtc tgcacggccg acatagtcga gagaaccgtc agcgcggagg cgggccacat 2703541 ccccagtgcg gtacatccgg gtgcctggag gaccgaacgg atcagctatg aagcgttcag 2703601 atgttaaacc aggccggcct agataacctc gtgctaaccc cgctcctgat acatacagct 2703661 ctccggcaac acccggcggg accggctgca ggcgttcatc cagcacgtat acaccaagat 2703721 cgggaatgcc gcagccgatc aagctgtttg cccgtaaagc tgccatgctt cggtctaatt 2703781 cgatatagct cacatgcacc gtcgtttctg taataccata catattgata agctgcggtc 2703841 tattttcagg gtggcggttg taccaatcct ctaaacggct gagttcaagc gcttctccgc 2703901 caaaaatgac atagcgcaga ctgagtgcct gtccgagatc cggctgttcc cgttccgcct 2703961 gcataaactg atagaaagca gacggtgtct ggttcagaac agtcaccccc tctttgacaa 2704021 gcaggcgcag aaacgcttct ggcgatctgc tgacgtggtg aggcacgatt acaagacgtc 2704081 cgccatgcag cagaggaccc cagatctccc acaccgaaaa atcaaacgca taggaatgga 2704141 acatggtcca gatatcacct gagctgaaac ggaaccagtg ctcggtcgct gcaaataaac 2704201 gtgttacatt ttggtgagga atcatcacac cttttggaac acctgttgag ccggatgtat 2704261 aaatgacata tgccgtattc aaaggggaaa gcggctgagt cctatcctta ttttttggat 2704321 tacctgcagg gtacgtgttt agtttctctg ccagctcggg atcatccagc acgattttcg 2704381 gcacgttttc aactggcgga atgtgatttg cagctttagt gttcgtcatg ataaacgcag 2704441 gctgtgcatc ttttagcata aaagcaattc gatcagccgg ataatccgga tcaagaggga 2704501 gataagctgc cccggccttt agcaccgcca ataggccgac agccatttcc aacgatcggg 2704561 gcagtgccaa tgccacaaat tgctccggcc cgacaccttc actaatcatc attcgggcaa 2704621 gccggtttgc tctttcattc agctctgcat agctcagttc ctgattttca tatacaacgg 2704681 caatggcatc aggacgtaaa gcagcctgct tctcaaattg ctctggcaaa catgcgtgcg 2704741 gaatcttttc agatacactt tgccaatcag tcaccatgct gctgtgttcc tctggcgcaa 2704801 gaatatccag atttccgatt tgctcgtcag gatcagactc ggcagcctcc aacaggcgca 2704861 tcaatcggtc agcaagagcc tgagcagttt cccgtttgaa aagatcagtg ctgtattcaa 2704921 gcagtccttc cattccgttt ggtgtcccgt cagcaaggcg atcttcacta atttccagcg 2704981 tcaaatcaaa cttggcagaa ccgacactgt tgattcgcag gctgctctcc atatcaggaa 2705041 gatgcagttc agcgtccggt gtgttttgga acgcaagcat gatttggaat aaaggatgcg 2705101 tcgcacgcga acgagccgga ttgagcacct ctacaagtct ctcaaacggc agatcctgat 2705161 tgtcataggc ggccagattc acttcccgta ctctgtctag aagctcacga aagcttgggt 2705221 caccggacgt atcagttctg agcaccaatg tattaatgaa cagccctaca agatcgccca 2705281 gcgcatcatc attccgtccc gcgatcggac tgccgatcgg aatgtcggtg cccgccccga 2705341 gccttgtcaa taaagcggcg agaccggatt gaagcaccat aaacaggctc accctatttg 2705401 cgcgagccag ctcctgcaat cgcttgtgaa actcgggctc aatacgaaaa tgaatcgtat 2705461 ctccatcatg actcggctca gccggacgtg aataatcggt tggcagttca agctgatcag 2705521 gcaggttttt caaggtttct ttccagaaag caagctgtcc ggcaatcaag ctatttggat 2705581 catcctcgtt tccaagcagt tcttgctgcc aaagcgcata gtctgcatac tgcacagcaa 2705641 gaggcgccca ttcgggagat cgtccgtggc agcgagccgc ataagctgtc ccaaggtctc 2705701 tggtcagcgg tgttaaggac cagccgtccc cgacaatatg atggacgaga agaagcagca 2705761 cgtactcgtc aggaccgatc acaaaaagct cggcacgaaa agcaggttca gctgcaagat 2705821 caaagctgta gcgtacagct tcggcaagcc gatcagaaag ctccttctca gcaatttcag 2705881 taacatgtaa ctcgggacag gctcgatcgg catctaaaat atgctgatag gatgtcccct 2705941 gtgattcagg gaagatcgtc cgaagacttt catgacggca gacgaggtca taaagtgccg 2706001 ctttcagcaa tccttgatcc aactcacctg acaaacggac agcaaccgga atattataag 2706061 taggactcgg tccttccaga caatgcagga accatagccg gcgctgggca aatgagagcg 2706121 ggatcttttc aggccgctca gctctctgca aagcgggaca tgcactctgc gccaaatcaa 2706181 gatgggcagc gagtccggct actgtcggtt cgtcaaagag cttggcgata ccaagttcgg 2706241 ctcccattac ctcgcgaatg cggctcatca gacgggctgc aagaagagaa tggcccccaa 2706301 gctcgaagaa actgtcatcg ataccgacgc gtgccaaacc gagaacctct gcaaacaagt 2706361 cacacaatat ctcttcctga ggagtccgcg gggcccgatc actgacagat gtgctgaagt 2706421 ctggtgccgg cagtgctttc cggtcaagct tgccattagg tgttaacggc agctcgtcca 2706481 tctccacaaa cgccgacggt accatataat caggaagact agcccccata taacgacgaa 2706541 gctctgcagt atcaatagca gcatcagcga ctacataagc cgccaatcgt ttgtctcccg 2706601 gctgatcttc ccgtacgaca accgcggcct gttcaatgtg cgggtgattg gcaagcacgg 2706661 catcaatttc tccaagttca attcggaatc cgcgaatttt gatttgatga tccgcccgcc 2706721 cgatataatc caaagaccca tcggcgcgcc agcgggcctg gtctccggtc cgatacatcc 2706781 gagttcccgg cggtccgtat ggatctgcaa cgaagcgctc cgccgttaaa tcaggacgat 2706841 ggaaataacc tctggccaag ccggttcctg caatataaag ctctccgaca acgcccggcg 2706901 gcaccggctg caatccatta tcaagcacat acacctgcgt gttccaaatc ggtttcccaa 2706961 tcggaggaac gcccttcagc ccttcttcaa gaaaagctgc ggcagaccaa atcgttgttt 2707021 cagtgggacc gtataagttc gtgactgaac aatgaaggtc ttgaagttcc tgcaaaagac 2707081 cgctcggcag cgcctcgcct cctacaagca ctctaagccc ccgaagtttc tcaggttcac 2707141 tcgttaccaa agcgtgccac agtgtcggtg tcgcctgcat aatgttaata tcgaaatttt 2707201 caatcatttg agctaatgcc tgcggctcac ggatcgtttc tttctttgcg atcacgattt 2707261 gcgctccgct aatcagcgga agatataact ccaatgctga aatatcaaaa gcgacagtcg 2707321 tcacagccaa cagcctgtct tcttctccta gagaaaatgc ctcctgcata gacagcagaa 2707381 aattgcttaa gcttttctgt gtcacaacga ctcccttcgg tcttcctgtt gatcctgagg 2707441 tatagatgat atacgcagga tggtcaagcg aaaccgatac atcctgattt tccggcgaat 2707501 agcgttttat aatctcctgt gtaacagcct gatcaagcac aagctcaggt acagccaggt 2707561 catcaggcag actggctgct atttcctcag tcgttatgat gcatgaaggt ttcgcatcct 2707621 ccagcatgta agaaatgcgg tcggctggaa actccggatc aagggggaga tacgccgcac 2707681 cagtcttgag cacaccaagc attgaagcca ccatctcagg ggaacgcggc agcgccaaag 2707741 cgacaaattg ctccggacca atcccttttt cgatcaacag acgcgcgagg cggtttgcct 2707801 cttcattgag ctttcgatag ttgacttgaa tgtcatcaca catgagagcg atacgttctg 2707861 gcgtaagaac tgcctgcttt tcgaacatgt cctgaaggct gaccagcttc tcggattttg 2707921 ccgtctcatt ccatttagaa atgacttttt ctttctcctc tggcaacaga agctccattt 2707981 gcccaatcag catgtcctct ccggcagaag ccgtttgcag cagctgcaaa atacgctgct 2708041 gatgaagctt aatatcagac tcactgtata cctcgggatt cgcatcaaca tcaattcgca 2708101 gcccgctgcc gtctgttctg tcatatacat tgattgatag atcatcaaca ggaccggctg 2708161 aaagattatg cgttgtgccc cggacgccgg caaagtcgag accgtaatca aacggcataa 2708221 gattgatttg agggccaaat aatctatgat tttctcctat caatttcaga tcgcgcctaa 2708281 gctcttcatg gcgatactta tgatgtcgcc gaatactgcg gatttcccgg gaaatttgct 2708341 gaatcagttc agaaaagctc atcgaagagc ttaccgtcag ccggagcggg agaaggttca 2708401 tcaccatagc cggtacattc agtgacgcgg accctatccg acccatcatg ggcaggccga 2708461 gcacaacatc ctcagagccg gtcatacggt gcacataaac agctgacacc gcaatcatga 2708521 cttcatgcca gcttcctgag aaatagcgcg ccgcttcttt taacgcgttt acatcagacg 2708581 gaggcagata tgccgtatga cgaagaaaac tgttagatgt tcttggcgcc cgatcagcca 2708641 agctcacaac ttcaggtgca tctgcaaaac ggtccagcca gaattgacga tccttctcat 2708701 actgctctga tccgcgataa tctgtatcct cctccaaaat ggcctggaga gacccaaagg 2708761 aacggctttt agctgtttgt ccttttataa gggcagtata tgtacttgcc acacgctggg 2708821 ctatcaggga aaaaccgaag ccgtcgatcg ctatatggtg aatgcgctga taccaaaaga 2708881 aacgatcagg cccggcaata aacagagctt cattgaacaa aggggcatac cctaaatcaa 2708941 ccggctttgc taaatcagct ttcatccagt ttaatgctgt tttttccgga tcaggctcag 2709001 agctgacgtc aatgacgtgc agctgtacat ccggagacgg gtttatcatc tgccaaggcc 2709061 cgtccatatt ttcaccgaag cggacatgca gcgattccgc ttccttgatc acgtgccgca 2709121 aagcttcttc aaaaagagca atattgactg gtccattgat ttctatatat tccgctgtat 2709181 tgtagattgg attgtccgga tcaagctgct gagcaaacca tatgccagtt tgcgccccgg 2709241 tcaaagaata ttgaagatct tttgtatcag gcatccgttt gtttaccctc cttttataaa 2709301 taatccgcgt ttggcagcac ttgctggctg cgagttgtga gcaatttctg ccattcttcg 2709361 atcgttgggc gttcagccaa ttccacgaaa gtcacctctg ccccttcacg gcgccattgt 2709421 tccaccaatg tcatgatcct taccgaatca agaccacgat cgagcaaatc ctcttgatct 2709481 gtgatgtctt ccggtgtttc ttgtagaagc tcagcaattt gtttacggat attctcacat 2709541 gtaaacacgt tctttttgcc agtgtttgct gacgtttttt gaacgtctgc cggcgcattc 2709601 tgcagctgat caagaagact gtcagtcatc acggtaaacg cacagcgtcc agccgcatat 2709661 tccagcgcca tttgatgttt ttctaatgaa aaatcagcaa ctgcatctcc cacaaaaaag 2709721 gctttaatat cctccataaa tgcttcacat gctgtaacaa gacagccgat atgggcgtaa 2709781 attcctgtaa tgatcagctg atcgcgtccc tctttgcgca tcatttcaag cagattcgtt 2709841 ctcttaaacg cgctgtatct ccattttgtc agcacaagat catcatcctc tggtgccagc 2709901 tcggttataa ttttctcctc ataaggaccg ctgtttaatc ccgggcccca aaagtctgtc 2709961 agcagcgcac ggtcatccgg attttggctt cccggctgtg cggtatagac aacaggaatc 2710021 ccaagctgaa cacattgatt cttcagcttt cgtatattcg ctgaaagctc tgttaccgga 2710081 gacgctcccg ctgtgaaagc atcaacaaaa tagttttgca tatcgtgtat taacaagaca 2710141 gcccgattcg gatcaggcac ccatgatact ttgttttgcg gcatatcaga tgctgtcggc 2710201 atttgatacg gctgaatggc aggtatagcc atatgaacac ttcctctcaa attgttgttt 2710261 tattttttaa atcctgcaag aagcttctcg gaaatggctt cacggagcgc ttttttgctg 2710321 acttttccta ctcctgtctg cgggaaggat tcgacaaatt caactcgatc agggatttta 2710381 tatgccgcca gtccgcgctc tctcaaaaat gctttaagct ctgcggcttt tggggcttca 2710441 tcccggggaa taatgaacac acaagatctt tcgccaagaa attgatcagg catggagacc 2710501 attgccgcat catggacagc cggatgcgcc agcagatgat tttctacctc ttcagccgca 2710561 accttttctc ctccacggtt aatttgatcc ttcgcccggc cttcaacgac aatatagccg 2710621 tctcgtgtca gcctgacgat atcacccgta cggtaaaaac cgtcctcagt aaatgaagcg 2710681 gcgttatgct cttctgcctt atagtaacct cgaattgtat acggcccccg cgtcagcaga 2710741 tggcctgttt caccaggttt tacgtcgcga tcatgatcat cccaaacacg catttcatca 2710801 tatggagaca tcggttttcc ttgggtgttg acaatgatct cctcaggatc atccaatctc 2710861 gtataattga cgagaccctc tgccattccg aacacctgct gcagcgtgca gccgaaaaca 2710921 gcttttaccc tgcgcgcggc ttcagcacta aacttggcac cgccgacctg cagcacttga 2710981 aggctggata aatcatcacg gcgtgaggat gccgcatcca tccataccat cgcaagaggc 2711041 ggaacaagag cggttatcgt gaccttttcc cgttcaatta aaggaaatgc gtcatctgga 2711101 cttggagaag gagataatac cactcttcct ccagcgtata atacgccgag aacgccgggt 2711161 gagctcagcg gataattgtg tgccatcggc agcgcggcca agtacaccgt gctgtggtcg 2711221 agccagcaga cctccacact ccgcttcagg ctgtatatgt agtcatcgtg ggtcctcgga 2711281 atcagtttcg atagcccggt gctcccgcca gaaagctgga ggaacgccac atccgatgat 2711341 ttgacttcag gcagttttac aggttctgca tgcaaatcct ccagcggtaa aaattcctct 2711401 gcctcacctg cgacaatgat gtttttcaaa gtcggcagct tgctttgaac ctgtctggca 2711461 agcgaacggt agtcaaaacc ggaataagcg tcgggaatga tatatgcagc cgcttcagca 2711521 aactcgcaaa aatatgtaat ttcactgctt cgatgagaag gcagtgcgaa gactggaagc 2711581 gcccccagac ggaaaagcgc gaaaatgact tcaaaaaact ctttgatatt tggcaactgc 2711641 accacaacac gatccatctg ttgaatgccg agcttttgaa atccggcagc caggcgatca 2711701 gcccttgtgt caagctctcg atagctccaa tgggtgtttc cgcatgtaat ggcaatgcga 2711761 tcaccatatt tggctgcccg gtcccttaac aaatctccaa acgtctcacc ggcccagcag 2711821 ccgttctttc gataggtctc agctaactca tcaggccaag gcgtaaatcc tttcagcatg 2711881 ttgtatccct ccagcaattc attctgttca tatgtgatcc acgcccattg cccgcagcat 2711941 tgtccgaaac tttgcggacg tctcctgaag ctcgtcctca ggctttgaac cggccacaac 2712001 accagctcca gcatacaggc ggagtgagcg ttcttctgct tctgcacaac ggatggtcac 2712061 gatccattct ccgtcaccgg catcgtcaca ccatccgacc atgccggtaa agaaaccgcg 2712121 gtcaaatggt tcaatgctga gaatcgcttc tcttgcaaga tcagtcggtg ttccgcagac 2712181 ggctggcgtc gggtggagcg ccgccgccaa ttcaagtgcg gttacagacg ggtcggaaag 2712241 ctctccctta atcacgctgg acaggtgcca catcgtttcc gttttgatca gtgaaggctt 2712301 ctccggaacc tccagcgtcc ggcagaaagg tctcagcgct gccgcaaccg cgtcagcgac 2712361 aaccgcgtgc tcatgaagat cctttgcgga agaaagcaat tcagctgccc ggcgctggtc 2712421 ttcaacagga tcattactgc gcggtcttga gccggctaat gggttggaaa cgacctgtgt 2712481 tcccatcctt gaaacgagaa gctccggact tgctccgagc aatgttctgc ggggagacgt 2712541 ttcctcctga ctggacacgt ctgcggcaaa cgtgtagcca tgcgagttat gctgagccag 2712601 atggcgaagc aattcatccg tctgaatcgg ttcaggcgat gtcaaatgca gcgatctgga 2712661 caggacgatt ttgctgagtg ttccatcggc aatgcgtgcc agcccttgtt caacaccatt 2712721 tttataatcc tcaggttcag gaacaggctt tatgtggtat gtatgcccag cctgctgttc 2712781 cttttcctca tgatcaaatt gaagcggtcc tgaccagcgc acttcttcag gtacaacgag 2712841 ccgcgctgct tttacttgat caaaaggaac ggccccgaca acaagcggcc ggctttgccc 2712901 tgattgtttt gcctgacgta acgcctctgc aattcggcca gaaagggttt ccatttggtt 2712961 ttgcccgtct gcctccggta caatttcaca tatgcctttc gctaacagta cacgatgagg 2713021 agacgctaag aaaaaggcgc ccggctgata ttcatgaagc aaatgctccg cttttgtttc 2713081 tgttataacg ttttgatcca acattctcat gaacctcctt taaattcagt tacacgccta 2713141 aggtcgcgcc gccatctacg cataaattat gcatcgtaat atgccctgcc tggccagaaa 2713201 ccaaaaagag caccgcatcc gcaatatccg aaggcttggc tagttttttg agcgggatcc 2713261 ctgttttaaa tgtctcaagt gatcctttta tgacttgctc cgctccattc tcgtcggccc 2713321 ataatgacca ctgcatgtct gtttccgttg atccgggaga tacaatgttg cagcgaatat 2713381 tgtattctgc aagctcaagg ccaaggcatt tcgtaaacat cacagccgca gcctttgaag 2713441 acgcatatgc cgccatagat gttcttggta caccggcagc attcgatccg actgttacaa 2713501 tcgaacccga tcttcggtcc atcatatatt tgctgactga acgcgaggcg ttaaatacgc 2713561 cagtcgaatt cactgagaac gtcgcctccc attcctcatc gctaagcgaa tggatcagtc 2713621 ccgggcgaag gacacccgct acattcacta aaatatcaat cggccccatt tcacgttcga 2713681 tgcgcgccgt gatctcgtca atcgccgcgc tgtctctcac atccgcagga aaagcttctg 2713741 catggcggcc ttctgctttg aggctgctca caaccttttc cagcttttca ggattataat 2713801 caactgccgc aatatgtgcg ccttgactgg caagcgtccg cgcaacagct tcgcctattc 2713861 cttgggcagc ccctgttata aaagcaattt ttccctctat accctttgca ttcatatcat 2713921 caattccttt cttcgctcta aatgccaaac agacatccag cgaaaaagac tgctgcgcct 2713981 tgaaaaacgc aatctattga taatgattat cattatcaat tataaaaata atcatatcca 2714041 aatgtcatgt gacagtcaaa tataatttca gtgacaaata tttttttaaa ggcaaggctg 2714101 agtatgtctc agcccattga tagatgcggt ccgtcagggt gaagcgcaaa acgcagcgcc 2714161 ctgctgacca aaacaggaag aactgaaata tgtccttctc ctgaaaactc gcaaaattct 2714221 gcccgtatac cttgttcaga taaaacggcc agccgctcat aaagctccct tgcattatca 2714281 ttcatccggc ttttatgatg ctgctctaat tctcctgcgg caagcaggat attgataggc 2714341 tgattgtttt tcttggtgag agagacgaaa tggtccgttt tcttgagaat aaacggttta 2714401 ttccaatgaa tggacggact tcccgcgata tacgtttgaa acgcatcggg ctttgttagc 2714461 agcacctgca gcacgaaaag ccctccgagc gaatggccaa agattgtttg tcttttttta 2714521 tcaatctggt aatctcgttc tatctccggt tttaaatcct cttcaataaa tctgaaaaag 2714581 ccctccgctc cgccatgctc cggccattct ctgccgtcgg gcctttccgg cagcttcgat 2714641 tgggctgttg gcattgtaaa atcccggtgg cgtgctgagg agaacggctc cgctgtctca 2714701 tagccaatgc cgacgatcac tgcagggatc accccggttt tttcgggtcg gcgtccctgt 2714761 attcgaacgg cttccgtcat cgttccgaag acagaattgg catccagcag ataaatcaca 2714821 ggataaccag cgggtggcgg cggcgtacta ggtttcgaga taaaaatgtg ataggtacgg 2714881 ttttcattgc gtgaagacat catacgcact tccgtaccag gaatcgtaaa tgcgtttgat 2714941 gtcccgccat ttgtccggtc tgttgtttgt tctttcatgc agtacgacat tcctctcctt 2715001 aaactaaacc gcaatgtatg ataatgattt tcactatcaa ctagacacct caaataatag 2715061 gttttcttcc aaagaaagtc aactttttcc cgaataaaaa aggcaccttg atcaaataag 2715121 gtacctgcag actatcaata tggaagtaaa aacctaataa agatgcgtat tgtcctattt 2715181 gaaatagaac cttaatccca tgtaaacctt tgattttgcc aagggtcgcc tctcatgtga 2715241 tagccattcc gctcccaaaa gccagggtga ttttctttcg taaattggat gccgcgcagc 2715301 cacttggcgc ttttccaaaa atacagatgc ggaaatacac cccgcagcgg aaagccgtgt 2715361 tcaggggtta aaggttcgcc attatgcgca taagccagaa gggaagtttc cgctaagaaa 2715421 tcatcaagcg gcagattggt cgtccagccc tcttcagcat gtaaaatgac gtagcccgct 2715481 tcttctttta cacccgcttt ttccgctata tcacaagccc gcacgccttg ccacacatta 2715541 tcaagccttg accatcccgt gacgcaatga atgtcgtttt tcgattcata ccgtggaaag 2715601 gctttgacat cttcaaagct tagcagcatc ggatggtcaa ccaaaccgta tacttgaaga 2715661 ttccatttcg tcatatcttc gtaatatggg acatctccgg tatgaagcac aggaaatgaa 2715721 gtggtgacgt tttgatttgg cggcactctt ccagattgat cggactgtct tgtttttccg 2715781 aaatacatat gggcctcctt tttgttaacc taatttaaaa tcatgttgac aatctttttg 2715841 ttctttatta ctctatgatt gtgtatgtca acctaagggg gaacaacgat gaaacaacgt 2715901 aaacttcgtg cgggagatat ggcgctgatt ggcatgttcg ccgcacttat ggctgtcggg 2715961 gccaacatta catcagtagc acccttttta caagtagccg gcattccgct ttcgatgcag 2716021 ccgtttttct gtctcttggc agctttgctt cttggcagca aacgggcagc gattgccatg 2716081 attgtatatg cacttgtggg attggccgga gcgcctgtgt ttgctcaatt ttcagcaggc 2716141 ttcgcaccgt ttgcagggaa aagcggcggg tttattatct catacattcc ggcagcattt 2716201 gcagcgggat ggtttttaga acgaaacatt cagccaagta aaattcgatt tctcattgct 2716261 tcacttatcg gaacggcgat catgtatctc atcggcacta cctatatgta tcttgcactg 2716321 aagctgtgga ttcatacgcc agtgagctac ggcacggctt ggggctttat gatttggttt 2716381 atggtaaaag atacagcgct ggctgtgata ctgtcgttta tcgcaccagc aatctaccgc 2716441 tctattcata aagcaaccgg ctttaacaga aatcacatat catctacgta aaaaccgttc 2716501 tattggacgg tttttttatc ataacgagaa aaggctcccc agtaaagggg agcctttttc 2716561 ctataaaaca agcgctgcaa tccagccaaa gatgacaagc ggaatattat aaaatataaa 2716621 tgtcggcaca caagtatccc aaatgtggtg atgctggccg tccgcactca aacctgaagt 2716681 cggcccaagc gtactgtcac tggcaggtga accggcatcg ccaagcgcag cagcagcccc 2716741 gataatcgca atcgttgcca tcgggctgaa tccaagctgc atgcatagag gcacgaaaat 2716801 ggttgtgata acaggaatgg tcgcaaaaga agatccgatc cccattgtaa ttaataagcc 2716861 gacaatgagc atcagcaatg cgcccaagga ctgactgtgt ccgataaaac cagctgacgt 2716921 tttgaccagt gactcgacat ctccggtttt cgtcaatacg tttgaaaatc cggctgcaac 2716981 aagcatgaca aagccgataa aggccattaa aaccattcca tcagtaatca gtgagtccgc 2717041 ttcatcacgc ttcatcacac cgctgacaaa cagaacaatc agaccagcga gcgcccccat 2717101 aatcattcct tctactccca aagtctgaga taagtaaagc tggacgccga gtgacacaac 2717161 aatggctaga accgcgatac caatactttt tctcgtatat ggcgatgctt ctgcacctga 2717221 aatgtctttt gtttcatatt gtttcggttt acggtatacg atcactgata aaataaggcc 2717281 gacaaccata cctgcaactg gaataatcag tgcgtacgga atatcagcaa gcggaacgtt 2717341 taacccggca tccgccatat tgtccttcag catgccttgg aagatttggc cgaaaccgac 2717401 cggaagcaaa atataaggag ccgttaagcc aaatgtaatt acacacgcga tcagacggcg 2717461 gtccatttca agttcattaa agattttcaa aagcggcgga atcagcaccg ggataaacgc 2717521 gatgtgaacc ggaacgacgt tttgcgaaaa acaagataca attaaaataa tcagcacaat 2717581 cagcacctta gacagtgctt tttttcgaga atcttcttta tttccgatta atttaacgga 2717641 ggcttccacc attgcgtccg gaagacccgt tttcgtcaaa gcggcggcaa acgcgccaag 2717701 catggcatag ctaactgcaa cggtggcatt tccgccgaga ccgtctgtga aagctttaac 2717761 cgtttcgcca agaccgagcc cgcctgttaa cccgccggcc aaggcgccta taattaatgc 2717821 gataacaata ttgacacgca gcaggcttaa tacaagcata agcaggactg cgatgacgac 2717881 tgcattcatg atgatacccc tccaaaaatc ctttagtttg ctaatgtagt agataaataa 2717941 agtacgaacg tatcgtatca taaccgatcc actttagtca actaaagatt tcggaagaaa 2718001 aaatccctgc cgcatcatac agcagggatt tttcattact cgtttttatc ttcttccaat 2718061 gtaaatcgct ccgcaagtgt agccagtgtt cttgccataa cgccagtagc cccggccggt 2718121 ccgaagcagg ttgctttatt ggcagtcgct gtgcctgcaa tatcaaggtg aacccaaggt 2718181 gttgactcag cgaattcacc aagaaacgtt cctgccataa tcgcatgtcc ctcgcgtccc 2718241 ggtgaattgc tgagatccgc catttggctg cttttcacgc gttttttatc cttctctgtt 2718301 atcggcagct gccagatcgc ctcgccgcac tcttgtgcag catcagctac ctgctggtaa 2718361 aagctttgat catttgtcat tgcaccggtt gtttctgttc ctaatgccac aacgacgccg 2718421 ccggtaagcg tagctacatc gacaagaact gatgcgccat gctgtttcgc gtatgtaatg 2718481 ccatctgcaa gcactagcct tccttcagca tccgtattaa ggatttctat tgtttttccg 2718541 cttaaagata cgatcacgtc atccggcttc atggccccgc cggagatcat attatcggtt 2718601 gatggaataa cgcacagcac gttttgttca ggacgaagct ctccgatcgt ttccatagcc 2718661 ccgagaaccg cagctgctcc tcccatatct gatttcatgc caacaattcc agatttcgtt 2718721 ttaatggagt agccgcctgt gtcaaaggta attcctttcc cgactagtcc gacgacgtct 2718781 tcccattcct ttttgccctg atatttcaac acaatcattt tcggcggttc ggtggagcct 2718841 tggtttaccg caagtattcc gcccataccg agctcttcca tctctgattt ctccaatatc 2718901 tcacactcaa aatcatattt cgccgcaagc tcttcagcat acgaagcgag gtcagtcgct 2718961 gtcagcatgt ttcccggcat attcacaagc gttctagccg aatttgtccc ttgtccgtat 2719021 gcctggccga cgcgaagccc tgcctgcact tcctgtgtat cttcatctgt tacaacatac 2719081 acggcttcaa tttgtttgtc aggctcattt gatttatgct tataatcctg cacctcatag 2719141 gaagcaagca ggcagctctc agctaaagca tgagcggcat cggctggagg cacgtcttcc 2719201 gaaataaacg tatcaagcag aacagcagtt tcttgttttc gatctttatg aatggcttga 2719261 aaaacatgag caaaacgttc cttcgcctgt tcaaacgaat aatttgcttc tctccccagg 2719321 ccaacgaaat aaatccgttt catacccgca gaagatggag ggaatacttt tgatacttga 2719381 ttcggtttcg cagagacatc accctctttt aaaagctgtg tcagatggcc ttcgagcatt 2719441 tcatcaattt ccaacgcttt tcctgtcagc tggctttttt gaaaaagccc gacaacaagg 2719501 gtttctgtat gctctgattg ttgaaccgca taaaacatga ggcttacact cctaacgtaa 2719561 tgggtatttg taatgaacaa tggtataata ggaaaaacat tctttccact atacttattt 2719621 taacaaacaa cagtctaaga cttgcttttt tcttttgaaa cacgaaggat ttttcaaata 2719681 gaaaggatgt cgccgatgga acttttaacg aattttcctt tattatcaag cctggccgca 2719741 attatttttg ctcaggtcat caaagtgccc atacagttta tcgtgtccag aaaactggac 2719801 tggtcgctgg tcacaagcac aggcggcatg cctagctctc actccgcagc ggtcactgcg 2719861 ctttctacag gcgtagcctt ggagcatgga ttagactcct cactctttgc ggtttccgcc 2719921 attttcgccg tcataaccat gtttgacgca actggcgtca gacgtcacgc cggtgagcag 2719981 gcaacagtca ttaataagct tgttattgat tttaaccgtt tcgtaaatga agcgaaggac 2720041 ttccctaagg ctgcagagaa agaaaagcaa aaaaagctga aagagcttct cggacatcag 2720101 ccgatcgaag tctttttcgg aggattaaca ggtattttac tgacattggt actcgcttac 2720161 tttttcatgt aaaaaaaacg ctcctgcttt cgctggagcg ttttattctt tcaccgtttt 2720221 atattgattt ctgaacactt gcaaagattt tgtttcattg agcttctcaa gctcatcctc 2720281 ggtaatcttt cccgttccct ttttaatcac atatacatca agggtttttt tgccccattc 2720341 attgtataca tctttgactg tctcaaagta cagatcaagg cggtttccct taatagctga 2720401 tcctgtgtcg gccacaactc cgagaccgta gttcggaatg aataaaattg ttccgatcgg 2720461 gaaaacggac gggtcagcag caaccgtgga atataaatcc cgtttcactt tcacacctga 2720521 atatgtaagc ccgtataatg gatcaccggg atttttgccc gtcgactcag ctcctgctgt 2720581 gtagcctgtt gctgttactc tttggactgg atattcatcc caatcaaatg cctcttctaa 2720641 cggttttgtt ttatcctcag ccgcggacgt ggtttgtgtt tgtttctgct gcaatgcttt 2720701 taatctcagt cctgcatgct tcaagtgctt ttcctgatgt tcctgcaccc attttgacaa 2720761 gtccttcgct tcaattcctg acactgataa aaatgtcgtg ccaaatgcaa gcagaaataa 2720821 acaggtcatc agcaaacgtc tgatcatatt caacatcatt cacctctcct ccgaatcatt 2720881 gttcccaagt ggagagagca ttattcaaaa tggtgaatga gctgaacgca taaaaaaagc 2720941 tttctttaga agaaagcggc atttaaaaca tttgatatcc tctttttcta agcatgttga 2721001 tcgctatacc ggacacgatg gcgccggcca aaccgctgac taaaatcagc acatcagcag 2721061 ccgctaatga taagacacga tgaaacaggc tggcaaagga ttctcccggc gactggacat 2721121 agctgatcag cttttctttg ctgataatga aaaggcatac aattggataa atcacagcca 2721181 taatccaaga cattctcagc agcatgttta ataagaaacc gattccaaaa aacaagacaa 2721241 aaaacaaaac aattgagatg attacgactg gcagactaat caacctattc cacccccctg 2721301 cgttgttttt agtgtaacgc gggggctgaa ataaagtcaa cggctggaaa aagaatgact 2721361 gtcttttcct gtcccctggc aagacggaca agtctctgaa ccgccgagaa tcaattgaaa 2721421 atatcctttc cctgaacaaa atgggcatgc atgtgaagcg gttgtcgttg cagttttcat 2721481 ctaatcatca ccctttttct taattttctg ataatatacc atatcaagct gtcaacaata 2721541 aagtcagatc atgtgacaaa tcttttgatg taagcggaaa catacttgtt ttcctctcgt 2721601 tctcttttta ttttggcgtt ttttaataaa gaaaacccgc ttccgcgggt ttttagaaaa 2721661 acttgaactt gccttttttc aatgtcagtc cgagtccgcc aatcataaac agtgagcggt 2721721 tatcaatgac ttttttcata aacgaagcgg gcgtgccttt cagctttctg ccataaacaa 2721781 ccccaaccgc gttatgctcg ccaagagaag ccactgttcc cttaatgtcc ggcttgaatt 2721841 cctcaagctc tccgccttta ataagcctgc caaggttttt agcgaccgtt atgccctgct 2721901 gcattgcaat ttgcgcagtc ggcggatacg ggcgctctgt atcttcattc ataaacagcg 2721961 agctgtcgcc gagaataaag acattgtcat gtcccggggc gcggagatca gggttgactt 2722021 tgactcggcc gcgcatattc tcaaaaccgg cttcctccac aatcggatgg ccgcggacac 2722081 ctgccgccca tacaacggtt tgcgatttga tctgctctgg ttcttcatct tttttgccga 2722141 ctctgactcc ttctggtgta cattcttgta cagccgttcc gatcttgaac tcaactccgt 2722201 tttcctcaag ataatgtacg gcgtaatcaa caagttccgg atcaaagccc ggcaaaacgg 2722261 tcggcgctgc ttccacacaa atgatgcgga caaggcttct gtcaacgtca tattccttac 2722321 agagctccgg cacgcgagca gccagttcgc caagaaattc aattcccgta aatccggcac 2722381 cgccaacaac gatcgttaac ctgtccggcc gtttttccgc ttccgtattg taagtcgcaa 2722441 actgcagctc aatatgttcc cgcagcaggc gcgacgtgtt gatgttggca atcggaaacg 2722501 catattcttt taagccttta atgccgaacg tttcaggcac ggcgccgagc ccgatgacta 2722561 aataatcgta ctgcaattct ccattcgcaa gcacaacttt tttctcatca attttgattg 2722621 cctttacggt atcctgtaca aaattcaccc gtgactggtt gattacatct tttatctgat 2722681 aacggcagcg gtcatgatgg agcgtacccg cgctcgcttc atgcatccat gtcgtttcat 2722741 aatgataatt gtgtttattt acaagcgtaa tgtcagcatc attcggcccg acatacttcg 2722801 tcagccttgt caccgtcatc aatccgccat atcctgcacc taaaatcacg attttgggct 2722861 tattcaatgc catcacatcc accttctctt tttttgcttt tgttagaccc ataataaaat 2722921 catcatttgt gttagcttca gcttattggc gggattttat gaaatatatt gaaaagtttt 2722981 ttgtgaagtc cttacccgta gcactattat catgtttatc cggctggccc aagaaacatt 2723041 cagaaaaaga tcatttcatt tggttattat cgtagcggcc tgcggaaata ttttcaagaa 2723101 cggatgggca cgttagatcc ttacgatttt ttctgctgac tcgtcaattt gaacggcaat 2723161 atggtataat taataacaat tttcatttag gaggcaattt tcgtatgcga gaggatacaa 2723221 aggtttatga tattacaatt ataggcgggg gaccggtcgg cttattcacc gctttttacg 2723281 gcgggatgag acaggcaagc gtcaaaatta tcgaaagcct gcctcagctc ggcggacagc 2723341 ttagcgccct ataccctgag aagtatatat atgatgtagc gggattcccg aaaatccgcg 2723401 cgcaagagct tatcaataac ctaaaagagc aaatggcgaa attcgaccaa accatttgtc 2723461 tggagcaagc ggttgaatct gttgagaaac aagcggacgg cgtgtttaag cttgtaacaa 2723521 atgaagaaac ccactactct aaaacggtca tcataactgc aggaaacggc gcattcaaac 2723581 cgagaaagct ggaacttgaa aatgccgagc agtatgaagg caaaaacctc cattacttcg 2723641 ttgatgatct gcaaaaattc gccggcagac gcgttgcgat ccttggcggt ggagattccg 2723701 cggttgactg ggcgcttatg cttgagccaa tcgcaaaaga agtatcgatc attcaccgcc 2723761 gcgacaagtt ccgagcgcac gagcacagtg tggaaaacct tcatgcgtcg aaggttaatg 2723821 tcctgacacc attcgtccct gcggagctga tcggcgaaga caaaatcgaa cagctagtgc 2723881 ttgaagaagt gaaaggcgac cgcaaagaga ttttagaaat tgatgactta atcgtcaact 2723941 acggtttcgt ttcatctctt ggaccgatca aaaactgggg cctggacatc gagaaaaatt 2724001 ccattgtcgt gaaatcaaca atggaaacaa atatcgaagg cttctttgca gcaggtgaca 2724061 tttgtacata cgaaggaaaa gtcaacctga ttgccagcgg cttcggcgag gcaccgacag 2724121 cagtgaacaa cgccaaggct tacatggacc cgaaagcccg cgtacagcct cttcactcaa 2724181 caagtctttt tgaaaataaa taataaaaaa aggagcttgt gtctgcgaca cagctccttt 2724241 tttatttgaa gatatttata taattcaatg cagttcctac aaccagcgca atcacaaggg 2724301 ctgcgactac ccagatcatt gccataataa tgcggtcctg aatcttttgg gacttcggtg 2724361 ttttttcttc gttttgggcc atcttattcg ctcctttccc atgtccatgc cataaagaaa 2724421 gcctggtgct gaacgaccaa gctttgctga acgtatatca ttcgcgtttt gatccgctct 2724481 ctaagaccat tcgttaaaac tatgatacct aaactcaccc tgcatgacaa gcttcggcac 2724541 ttgcaccaca cctgccagca aatcataatg tttgacatcc taaataaaac agagtacatt 2724601 atataaggcg aacatttcat atattatact tttaaatatt cgtttttagg agtgaaaacc 2724661 atggaaaacg tatttgatta cgaagatatt cagctaattc ctgcaaaatg cattgtgaat 2724721 agccgttcag aatgtgatac atccgtacgt ttaggcggac atacatttaa attgcccgtc 2724781 gtccctgcca atatgcagac gattatagat gaaaaactag cgatttcatt agccgaaaat 2724841 ggctactttt atgtgatgca ccgatttgag cctgagacac gaattgattt tattaaagat 2724901 atgaacgcac gcgggttatt ctcttctatc agcgtgggcg tcaaagatga ggagtatgaa 2724961 tttgtccgcc agctggcaga agaaaatctg actcctgaat acgtgacaat tgacattgct 2725021 cacgggcact caaatgctgt cattgaaatg atccagcacc ttaaaaaaca tttgccggac 2725081 agctttgtta ttgctggcaa tgtcggaacg ccggaagcgg tcagagagct tgaaaatgcg 2725141 ggagcggatg ccactaaagt cggcatcgga ccgggaaaag tatgtattac gaaaatcaaa 2725201 acaggcttcg gcacaggcgg ctggcaatta gcagcgctgc gctggtgtgc caaggctgcc 2725261 agcaaaccga ttatcgcgga tggcggcatc cgcacccatg gcgacatcgc aaaatcaatc 2725321 cgattcggcg caacgatggt catgatcggt tcactatttg ccggacacga agaatcgcca 2725381 ggccaaacga tcgaaaaaga cggaaagctt tacaaggagt acttcggctc agcctctgaa 2725441 ttccaaaaag gcgaaaagaa aaatgtcgaa ggcaaaaaaa tgcacgtggc gcataaaggc 2725501 tcaatcaagg atacactgat tgaaatggag caggatcttc aatcttctat ttcttatgca 2725561 ggcggaacaa agcttaacgc catccgcaat gtggattatg tgattgtgaa gaattccatt 2725621 tttaatgggg ataaatatta atcataaaaa aacgccaagt cagcggttct ccgcttgagt 2725681 tggcgttttc tgctacttct tcagcaaagt aagcttatat ttgctttttg agtttatctt 2725741 ccatcagttc tgccatttgt tttgcatttg gattttcttc attttgcaac tgttcaatga 2725801 cgttcatata atccgtttca tttcggttct ggcttaattt atatgccgct tgaatgtctt 2725861 ccaccttaat cttaaatcca acaatacctt tcaattcact ttctaagagt tttggagaaa 2725921 gcttatccca taacacagga ttgtcacgat gtttttcgta tttctccaac atgattgtta 2725981 attcttctgc taattcatct ttctctaaca tacttgcttt tccatacatg tggacagcct 2726041 gataattcca cgtcggaaca ttttcgcgcg aataccagga agaagaaata taagcgtgcg 2726101 gtccctgaaa catcacaagc acatcttcac aggcttcaaa cgttctccac tgaggatttc 2726161 cataagcgaa atgccccgta atatagtaat gatcgtcttt tttattgaat cctaacggca 2726221 aatgtgtggc aattggtttt ccttgttctg ttgtgacaac cgtaccaaag gagttttctt 2726281 gtacaaaatt ccaaatttct tcagcatttg tgactttaaa atattttgga atatacatca 2726341 tcatccaccc ttcgaaaaat attatatgag tgttttagcc atgattaaat ccgtttgttc 2726401 ttcatcaccc atataaaatg agtgggcgcc ggtctgaaca aaccccattt tcttataaaa 2726461 ggcaatggca ttttcatttt tttcccacac acctagccaa atgttctttt tattacgttc 2726521 cagcgcaatt tctatcgctt tattcagcag atgtttgcca agcccatgtt tttgaaagct 2726581 gttctttata taaattctct cgatttcaag tgattcagca cccatttctt cagactgagc 2726641 atcatcgata ttgaccttta catatccagc gatttcatga tcaaagtaaa taaaaaagaa 2726701 ttgcgaagac atattagata actctttttc cagctgctca gtgttaaatg cgctttctaa 2726761 ataggctttc atattttcag gtgagttctg ttctttaaaa gtgtcattga atgtttcaat 2726821 actcaattgt tgaagtgttt gtaaatcttc ccggctgcat tttttcattt ttacactcat 2726881 tgttcggatt cagccccttt atttaaaatt caattgtctt gtgtcccttt tatatattta 2726941 aacacggaac acatactgac cttgttacca ttccaaaaat cttcttcatc accaactccc 2727001 tatcgtgatt ttgttgtaaa tgcaataaaa tatactccgc attaaatata tcgtaacttt 2727061 gctgtattta caacaaaaat caaacaacaa agcagcgttt ctcttgccga agttcccgga 2727121 actctctgca tcatttcccc ataataaaaa cgcctccctt aacgatgatt tatcgctaag 2727181 aaaagcgtca gtaatagttg ctatccgttt ttagtgctta gcactcttca ggcttgcctg 2727241 cattcgttgc tgttctgaac gaagaaccgc agccgcatga agcgatggcg tttggattgt 2727301 cgatggtgaa gccgccgccg agcatggatt gtttataatc aatcacggtg ccgttcatga 2727361 tgtcaaggct ttctttgtca actagaacag tgatgccgtg ctgatcaaac acactgtctg 2727421 attcactctt ttcatgctca aagcccatgc cgtaagaaag tccgctgcag ccgccgcctt 2727481 tgacgcctac acgcagaaac gcgttttctt cttcatgctc tttcatcata tcttttatat 2727541 gcaaagctgc tgcttctgta attgttaccg ggttgctcat cattatgaac ctccttttaa 2727601 aaaccggttg ctgtctttta ttataaacat gatcgttcca attctcaaac aaggtgtttt 2727661 acaagaaata gacaccctca caaacggttt cagccggccc tgtcatcatt acatggccgt 2727721 tatctttcca gtttatcacc aaatccccgc ctgctaaatg caccgtgatg tcttgatttc 2727781 gctttgatac gccgtttaat acagatgcga ctgccgctgc acatgctcct gtcccgcatg 2727841 cctgagtaat ccctgatccc cgttcccaga cgcggaaatg caattcttgt tcattcacgg 2727901 tttcaacgaa ttccacattg atgccttccg gaaatctcgg atctttctca atcaccggcc 2727961 ccagtgtcgt taagggtgcc tgttcaatgt ctgcgatcgg aaaaacgata tgcggatttc 2728021 ccattgaaac ggcagtgcct gttagttcta cttcaccaaa tgccatcgtt tcattgattg 2728081 tgtgctcttc cccgccgtca agcataggaa gctcggattt tgtcaagcgc ggttcgccca 2728141 tatcgacagt gaccacattc acttttccgt tttcgacttg aacctccgct ttcacaagcc 2728201 cggagagagt ttcaatcaga aaagatgttt cctcaaccag cttatgctca tatgcgtatt 2728261 ttgcgacgca gcgcaggccg ttgccgcagt ttttcccttc agacccgtca ttattaaaaa 2728321 tccgcatttt aacaggcgct tggtctgatg ggcatatcag gatcattccg tcggatccga 2728381 tccctgtata aacagaagaa acctgaattg caatctctga cagtttttct tctggaagct 2728441 gttcttcaaa ttgattcaca taaatataac tgtttcccag gccgtgcatt ttggtaaatc 2728501 gaaatgagtt cataggtgcc tccaactttt tttctttttc ttagtataaa agctattata 2728561 agcggacaca atacaattat cccccgtttt tcatacataa aagctccttg cactgacgca 2728621 aggagctttt atcgtttata taaacatgcc ggcaatggct gcgctgagca gattggctaa 2728681 tgttcctgca agaacagcct tcaggccgag acgtgcgata tctgaacggc ggctgggcgc 2728741 taaaccgcca agcgtaccaa gcataatcgc aattgatgaa aaattggcga atccgcataa 2728801 cgcgaaactg ataatggtag cagttttctt agaaaactcg ccgatgtgcg aaccgaagtt 2728861 agaataagcg acaaactcat tcagcaccaa tttctggccg atatagcttc ccgcctgcaa 2728921 tgcttcatgc caaggcacgc caatcaaaaa ggcgatagga gaaaacacat agccgagaat 2728981 ggattctaat gttacgcctt ttaaaccgaa caagccgaaa gccccgccga gaataccgtt 2729041 tactacagcg attaacgcaa caaacgcaag cagcatcgcc ccaacattta acgcaatttg 2729101 cagtcctgtt gacgctccct ttgcagctgc gtcaatgaca ttggctgcgc cttcgccttc 2729161 atccattttg aaatcgcttt ttacggtttg cgttttttcc gtttcgggta taatcaattt 2729221 accaaagact agtccagctg gagcagccat aaagctggcc gccagcaagt actcaatcgg 2729281 aataccgaga agcgcgtacc caaacaaggt agatcccgca actgccgata gaccgctcgt 2729341 cataatcgta aacaactcag agcgcgtcag cccggcaatc aggggtttga tcactaacgg 2729401 agattctgat tgtcctacaa aaatattggc agcagccgcc agagattccg ttttgcttgt 2729461 tccaaggagc ttcgacaatc cgccgccaat gacacggaaa acgagctgca tgattttcaa 2729521 atgatataaa actgcaatca gtgctgagaa gaaaatgata acgggcagta cacttaatgc 2729581 aaatgccgga ctgtctccga cctttagaag cggtccaaaa ataaaactga tgccttcatt 2729641 cgcatagtca atcagaagct gtacacggct tgaaaaccat aaaaaaacag cgcgtcccgc 2729701 ttcccatttc aacacgatgt atccaaacgc cacctgtgtg cataaaccaa cgatgacggt 2729761 tcttatctta atattgcttt tcttttctga aaataaaaac gcgatagcaa tgatcgcaac 2729821 tgcgcccagc agcccccaca gaacattcat gaatactcgt acacctctta aattttattt 2729881 aaaaaaatat cttttatacg ataacaataa tattttttga tgtctacaca tttttttagt 2729941 tcttttgtac ggcaaaataa aaaagggcct gtccaggccc ttttctttaa aacattggat 2730001 tttcttcaat aaaggtatat atattctcaa caagctcagc aggcgtttca cccatgacga 2730061 cttctccgtt taccagagcg aaaagcgatt ccatacatgt cccgcagtag cttaagcagc 2730121 catattcaag gacatcaagg ttgggatcct tctccaaaat cgcccgggct tcctgagagc 2730181 cgtgagccag attgctgaca caaaattcaa tcattggatt catgcggttt cacctcacat 2730241 atgtccatta tcgcgaattt ttcactattc gtcaaagaca acggatgatt caaaatttat 2730301 tatcgtaaca tattatttct caaataacgt tttactaatt tgtgttttca ggctaaattg 2730361 taggttattt tgaaactatt attgtgattt tagatcaaat tcgatataat tctagatgtt 2730421 attttacata gttcgtattt tcttcaatgt atctatcata ctcttcggat taaaggggaa 2730481 ttcaaatgaa aaaattggtc ttgatcggcg gaggttacgg gaacatgcgc gttcttcatc 2730541 gcttattgcc aaaccagctg cctgatgatg tttcaatcac gttaattgac agaaatcctt 2730601 atcactgctt gaaaacagaa tattatgccc ttgccgcagg cacaatttct gaccatcata 2730661 tcagagtgtc attcccagag caccctcgcc tggatgtcca atacggtgat atcacatcaa 2730721 ttgatattgt acaaaaacaa gtgctgttcc aagatcgtga accgatttct tacgatgacg 2730781 ccataatcgg gctcggctgt gaggataaat atcacaacgt gccgggagcg cctgaattca 2730841 cctacagtat tcaaaccatc gatcagtccc gcgaaaccta ccaaaagctg aataatctga 2730901 gcgctaatgc caccgtcgcc attgtcggag cgggcttaag cggcgttgag cttgcaagtg 2730961 aattgagaga aagccgtgat gacctgaaca ttattttgtt cgaccgcggt aatctcattt 2731021 tatcaagctt tcccgagcgt ttaagcaaat atgtgcaaaa atggttcgaa gagcacggtg 2731081 tccgcattat taacagggca aatatcacaa aagtagaaga aggcgttgtg tataaccacg 2731141 atgatccgat ttctgcagac gccatcgtgt ggacagccgg catccagcca aacaaagtcg 2731201 tcagagactt agatgtggag aaggacgcac aagggcgtat tgtattaacg cctcatcata 2731261 atcttccagg tgatgaacat ctgtacgttg tcggcgattg cgccagtctt cctcatgcac 2731321 cgagcgccca gctggcagag gctcaagcag agcagattgt ccaaatcttg caaaaacgct 2731381 ggaatggaga agccctgcct gaatcaatgc cgcagtttaa gctgaaaggc gtcctcggtt 2731441 cactcggaaa aaaagccggc ttcgggcttg ttgctgaccg tccgctgatc ggccgtgttc 2731501 cgcgtatgct gaaatccggc ttgctgtgga tgtataaaca ccataacggt taatgataga 2731561 gaagaaccgc tgatcaagtc agcggttttc tgtataccca tgcttctcca tttcctcata 2731621 aacgtctttt aattttggat tgccttcacc gacaattttg tcttctacaa gcacaagcgg 2731681 ataaaaatac tcgtcatttc tgattttttc cgcaagctct ttcgcatgtt cattgtcagg 2731741 cggctcatga atatcgatgt actgcatctc aaaaggctga tttggatatt ttcttttcag 2731801 cgcagcctca agccactcgt atgtatcctt ggctgtcggc atatttacac agctcgcaca 2731861 aacgttttct gccccgtaca cgcttagcat gactggtttc atcacttgta gacgccccct 2731921 tctcctatgt aagtcctttc ttttaagtat acagagccta agggcgtttt tatagaaaaa 2731981 aaccgttttt gtgttgaagt ctgaatgtgc tataataggg aaagcaactt tgcaaaccaa 2732041 acaatagatt tttattgtta cactgaatat aatggtttta tgacgacgaa aggagcgaat 2732101 gtcatgactg aagttgaaat gaaagaacag gtgcaggaag tactggacaa acttcgtccg 2732161 tttttacttc gtgacggcgg tgactgtgag cttgtagacg tagatgaagg tatcgttaag 2732221 cttcgtcttc taggcgcatg cggcagctgc ccaagttcaa caattacgtt gaaagccgga 2732281 attgagcgcg ctcttcttga agaagtgccg ggtgtcgttg aagtagaaca agtcttttaa 2732341 taaagcagcc aggctgatat ttgatcagcc tggctttttt attagagatg ttgatcaaac 2732401 catgagctga tataattcag gcgcttgatc cgctgtcttg ggtgtccggt gcgtgataaa 2732461 ttgtgcgatg cattcggaaa acggacaagc ttggtttcct tgcccatttt tttcagagcg 2732521 ataaacagct gctccgcctg ctcgatcggg catcggtcat cccgctcgcc atgcagtatc 2732581 aaaagcggtg tctccacgtt tgctgcgtat tttaaaggag accggtccca gagcttttct 2732641 gtgtcctcaa acatgtcatg ctcaagctgc cagtctgtaa agaaatagcc gatatcactg 2732701 acgccgtgaa agctgatcca atttgatatc gagcgctggg taacggcagc tttaaagcgg 2732761 ttcgtctgcc cgacgatcca gttggtcata aaacctccgt agcttccgcc cgtgacaccg 2732821 agccgcttag gatcaatatg cggatctcgt ttgatagcct catccacagc ctgcatcaca 2732881 tcgtcataat cctttccccc ataatctcct ctgaccgcat tcacaaattc ctgcccgtag 2732941 ccgtggcttc ctctcggatt gatataaacg accgcgtatc ctttcgccgc cagcacctga 2733001 aactcatgaa aatatgtatg tccgtacatc atatgcggac cgccgtgtat gttaagaata 2733061 agtggatatg ttgtctcacc ttccatttgt gcaggcctca tcagccagcc gttcaccatc 2733121 acgccgtctt ctgtagcata ttgaatctct tcaggtattg atatcgtatg ctccctgaca 2733181 aacttgtcat tcgcgccagt cagctgtttc tcttcctgtc caagcgggat actgtaaagc 2733241 tcactcggtc tgtccggctt tgtcacactg gcaataaagt gctgttcatc aggtgaaaga 2733301 gaaaagctat tgatgtactc tttttccaga cgaatcggat acacaaggcc ttcaatcgaa 2733361 atataataga tgcccgtact gccttgatct gtgccgatga cataaaaccc ttggctgtcc 2733421 tttgtccaaa tcgggcgctg ttcagcacca ccgatcaatg aatctccaat cagcgcatcc 2733481 gctaaatgaa cgtccagcat ctcagtaaga catgtgaggc ggccttgttc gatatcatag 2733541 agccacgcct ttgagagcgt agcattctta tattcctttt catttccaag caaagcaaga 2733601 taccttccgt ctggtgaaaa tgagcttgat ccgaatgagc cgcgatgagg tgtaacctgc 2733661 ttaagatctc cagactccag tgacattatg taaacatcat gcggcttgct ggcatcatct 2733721 gtttcagtta aattagctga gaaaacaagc catttgccgt caggagaaaa agcaggatca 2733781 ccatgatcag ctttgtgact tgtcagctct ttcatctcac ccgactttac gctgacaagc 2733841 acaagctggg catacgcacc tctcgtcagc cctttgccgt cccgtttgta ggagaggcct 2733901 tgcacttcaa caggttcata gctgtcctgc tctgtttttt ctcggtcatc aatgctttcc 2733961 ccctctccca aactgacagt gaccagaatc gattcaccgt ccggggacca tagcggcttt 2734021 gacacgccat atgggatatc agtcagtttt cttgcttctc cgccttcagt gctcatgata 2734081 taaagctgtg ccgcatcgcc ttctcgatca gaaataaagg caagcgtgcg cccgtccgga 2734141 gaccatcttg ggtcggtgct tcgcttttct ccatgtgtcc aaggaacaga tcctcccgtt 2734201 ttcgtttcat agatccatat atttgatgta tacgaatctt tctcttgatt tacttgtgat 2734261 tttacatatg cggcacgggt accgtctggg gcgtattgag gatcggtcac agagacaatc 2734321 gctgtgatgt cgtctgcggt tatcagcttt ttcatattca tctcctcctt tttacatgta 2734381 tttcgttttt ctaaataaaa actcctttat ctccagcaaa aaaaagcgcc ctccgctgac 2734441 gctgaggaac gcttggcatg atctatacac tttttacttg atataaagga tttcgctcta 2734501 ttatacttcc ctctttcgga acggtcaaag cgtctacttc acaatgaggg aaatgaagcg 2734561 cgagctgttc ttttagctct tctccctttc ctttttcggt catgacgaga atcgttgggc 2734621 ctgctccgct gagagccgtt ccatatgcgc ccttcatctc ggcgacgtgc tctacttttg 2734681 acagctcagg cacaagcatc gcccggtacg gctgatggaa catatccttc ttcatgattt 2734741 tcccgacaag cggccaatcc ttggacatga tcgcagcaat gaggatattg ctgacagcac 2734801 ttgcttttac ggcatcggca tatggaaact ccttcggaag cacgtctctc gcgtctcttg 2734861 tcagcacttc ataaaaagga atgacaacga ctacgtcaat gtcagcattc gggacgcgga 2734921 tcatttgggt ctcgtcatcc tcatgcaggc cgatcacaag tccgccgacg agagaagcgc 2734981 cagcattgtc cgggtgtcct tcttctagac tcgctaaatg cagcttgtcc gcttcagaca 2735041 gctttaagcc gcataattca tcagccagtt caatggccgc tacaatcgct gcggcgctgc 2735101 tgccaaggcc gcgtgcaagc gggatgtcgc tccacacctt cacatggaca ggaggcattt 2735161 cttttccgta caaatctgcg gtccgtttag ccacttggta gatcaggtta tctgtacccg 2735221 ccggaattcc ggcgactgtt tctgtttcag cctcaaaaga ccatttgtcg ctttcaaaga 2735281 cggtcagctt caaatatctg ctgagcgcca ttccgactga atcaaagccg gggcctaggt 2735341 tagctgtgct tccgggaaca gtgacagaga acagcatgtc ggcttcgttc atacacgggc 2735401 cgctcctttt acatattcaa ggatgctgtc ttcatcagtc ggcaatgtga caggcttgat 2735461 ttctgaaatg tcgaccgctg tgttcggatc tttcagtccg tttcctgtta acacagctac 2735521 gaccttgctg cctttcggaa tttctccgga tttcacctgt ttcagcactc ctgcgataga 2735581 cgcgcaagaa cctggttctg caaacacgcc ttctacacgg gcgatcagct gatatgcgtg 2735641 aaggatttca tcatcagtga cttcgtcaat tttcccattg gattcctcgg ctgcctttac 2735701 agctttgtcc cagcttgccg ggtttccgat acgaatggct gtcgctattg tttccggatt 2735761 ttcaatcact tcattgcgca cgattgccgc cgcaccctca gcttcaaagc cgcgcatttt 2735821 cggaaggcct gtgccgtttt tctcatgata ttccttgaag cccttccagt acgcagtgat 2735881 gtttccagca tttccgaccg ggatcgctaa aacatcaggc gcttccccca gctgttcgca 2735941 cacttcgaag gcagcagttt tttggccttc aatgcggtaa gggttgactg agttgacaag 2736001 ggcaatcggt gatttctcac agatggaacg gacaatttta agcgcatcgt caaagtttcc 2736061 gtcaattgcg ataatctcgg ctccgtacat gacagcttga gcgagttttc caaatgcaat 2736121 ttttccgttc gggatgatga caatgcattt catgttagca cgggctgcat atgctgccgc 2736181 agcagcggaa gtgttacctg ttgacgcgca cataatcgtg tcattgcctt cttcttttgc 2736241 ctttgccaca gccataacca ttccgcgatc tttaaatgat cccgtaggat tgacgccttc 2736301 cgttttgaca tgaagctcaa ttccgagctg ctcagacagc ttcggcaggt gaataagagg 2736361 tgtgtttcct tcatgtaaag ttagcgccgg tgtttgatct gttacaggta aaaattcttt 2736421 atattgatgg ataagtcctt tccacattag ctccaaccgt tcccttctac acgatatgtg 2736481 cttttgactt cttgaacgac ttccaaatca tttaggtttt gcaggatatc actgaaatca 2736541 gcttctgatg tatgatgtgt gacaattacg atttcagcta actcatcatg gcctttaatt 2736601 ggcagctgaa ggattttttc aaagctcacg ccccgctctg agaacacaga tgtaattttc 2736661 gagaatgaac caacctcatc ttttacatga attcttaaaa actgctgtgc ataaatgtca 2736721 gacggcgatt tcatgttttt ctcatattgc ggtccgacaa agctgttgcc ggttacacct 2736781 aggcgcatat ttttcatgac agcgacgagg tcagaaacaa cggatgtcgc tgtcggcatg 2736841 cttccggctc ccggcccgta gaacatcgtc tcaccgacag cctcgccgta tacataaaca 2736901 gcgttaaact cattatgaac agcagaaagc ggatgatggt caggaagcag tgtcggctgt 2736961 acgctgacct cgattttgct gccgtcacgc tgagcaatcc cgatcagctt cattgtatag 2737021 ccgaggcgtt tgctgaagct gatgtcctcg tctgtaattt gggagatccc ctttactttg 2737081 acgtcttcca gatccacgtt catcgagaag ccgaggcgcg ccaatatcgc cattttccgt 2737141 gcggcgtcaa gcccttccac gtcagaagtc ggatcagctt cggcaaaacc gagatcctgc 2737201 gcttccttga gcacttcctc gtatgggctt ttctctttga tcattttggt taagataaag 2737261 tttgttgtgc cgttcacaat tcccatcatt tttgtaattc gatctgatga gaggccttcc 2737321 tctaacgtgc gcagaatcgg aatcccgccg gcaacactgg cttcaaagta gatatcgcat 2737381 ccattttcct tcgcttcggc aagcagctcg gagccgtaca cagccattaa gtccttgttt 2737441 gctgtgacaa catgcttttt cgatctcagc gcgtcgacca aatattgttt tgtctgttca 2737501 acgccgccga tcacctcgat gacgacatca acatctggat catcaatgac atcatacact 2737561 tctgtcgtga gcacttcctt cggcaaatct acttctctct ttttctctaa atcttttaca 2737621 agcacttttt ttatcgtaac cggacagccg acctgatgca taagcttatc ctgatggtct 2737681 tgaataattt taacgacacc gcttccgacg gtacctaaac ctaaaagccc tacacgaatc 2737741 gctttcaaaa aaactccacc tttcttttga ttgtcctctt ggaaaagaca attgttaact 2737801 caacacagac atataagtta caaacattat ataagcccgc tcctgttttg acaagacatc 2737861 attaggctga attttgcgaa tgtaaacgct taacgcattg atatgacaag attctttatt 2737921 ttctaattat ttttgtcaga ttttctcctc accttgagct gcctttgccg agccagctga 2737981 cgcgtggaac aaacagcttc tgcgcccgca tattcatgaa ttcctgcgct gtattgagaa 2738041 attgttcata acgcccacag tcattaagaa tgaagtcaag ctgttcttca aaataatgct 2738101 tttctgattc tgatgacatg taatagcttt ctacgatttc aaaataatga agcgggaaaa 2738161 gcagacggct gtataaaagg cgtttcgaaa atgaagacag cggtgtgact tgctcgtatt 2738221 cctgtaaaaa gagaaagccc tgctgattaa aatcttgtct gtgatgcaaa aacgtatgcc 2738281 tcatatattc agccaaatca cgggaagcgt ggtcaaacac ccaatccgcc ggaatcctga 2738341 tcaatgattc cggtgaccat gtatgccttt ccatccgctg atggcatatc gttcctgaat 2738401 cagcggcttg gggcttgtca tccagctcag tgtccactaa atattgtatc gcgttttctg 2738461 acagtcctaa ataatatgga aatgattcga tcattttttt atcgaatggc tcatgcggag 2738521 gggtctgaac ctttctctgc caaaatgctt ccagctgatc aattcgtttt ccccacagat 2738581 ccttccactg gccgattctt ccggccgcct tcacctcata tggatatcct cggccttttc 2738641 ggtgaaattc cgcaagctcc gctccaatgg agaacgccct gtttgaataa gggggggccg 2738701 ccttcagcag agcgtacgtt tttccctcat gttcaaatgt cagttcacct tcttttgtaa 2738761 agataaaaac cgaaacgtat gggtcacttt gttcttgtaa atactgactc atgtaataaa 2738821 gctccgccag ctctgtttct gagaattggg aaacggggac aatcagaaag tatgaattag 2738881 gcgtctgaaa gcattgatat gtgtgctggt acatggaaag ctgcctgatg tgaatgccgt 2738941 atttttcttt tattgtacct ttcaccatga tcacctgcct gttgaattag ggctcatcac 2739001 atcgtagtca tacacagccg gaattatgaa tacatatttt aatccgaaga aggcgcaaga 2739061 aaaagtcgta aacttctcaa gcattttgta taaactagta aaaaagattg ggtgaagctg 2739121 atgtcagaaa acgaacaatt cagtcagatg gaagctaaag caagagcacg gatgaaggag 2739181 cgcggcgttg aggtatcaga cattgccgag cttgtctttt ttctgcagaa aaaatatcat 2739241 ccggatttaa ccattgatga atgcacgctg aacgtcaatc gtgttctcgc aaaacgcgag 2739301 gtgcaaaacg cgattttaac gggcattgaa ttggatgttc ttgctgagca gaaaaaattg 2739361 tctgaaccgc tgcaaacgat gctggaaata gatgaaagcc tatatggagt agatgaagtt 2739421 ctggcatttt ccattgtgaa catttacgga tcgatcgggt ttacgaacta cggttacatc 2739481 gacaaagaaa aacccggaat ccttaaacga ttgaatgata aatcaaccgg tgaatgccat 2739541 acctttttag atgacatcgt cggagcgatt tccgccgcgg cttcaagcag acttgctcac 2739601 cgcgcgcggc atacagaata agggcaccct tttagggcgc ccttttttca aatgtatgga 2739661 atccattcag tcagagagtc aatggcgtga gtcggttttt ccatatcgtc tgtcatatgt 2739721 tctcttttcg ttacgcctgt gtgaacgagc agcgtatcca tacccgcgtt aatgccggcc 2739781 ataatatcag tggcgtagtt gtcgccgacc atgagtgttt cagacacatc tgtgccgaga 2739841 acgcgcatcg cctgctccat aataattgat tccggcttgc cgataaatac aggctgtaca 2739901 cctgtagata cggttaacac cgatgtcagt gagccgtttc ccggcaggag ccctctttca 2739961 gtcggaatcg caatatctcc gttagtggaa ataaagcggg cgccatttct gattgccagg 2740021 cagccaacag caaatttttc gtatgtaatg gaacggtcga tgccaacaac gacaaaatcc 2740081 gcgttttctc cgccaaatgt caggccgttt tcttcaatcg cctggcggat tccttcctcc 2740141 ccaatcacat acacagacgc gtcttttttc tgctgtgcaa tgtgctgggc agttgccatg 2740201 ctggtcgtga agacctgctc ttctgttgcc ggaatatcaa aagacacgag cttgtccgct 2740261 acctgcttcg gtgtgcgcga agagttgttt gtcacgaaaa gataaggaac gccgcgatct 2740321 ttcagcgttc tgacaaattc acacgcctcc tcgatttttt ccgtgccatt gtacatcgtt 2740381 ccgtctaaat caattaaata ccctttatat gttttcatat ccaacactcc tgtggctttc 2740441 cagttgttat ttaaacgcgg aaacaggtcc tagctctgtt tccaaatagc ttctgatccg 2740501 tttcgggaag tcctgaagag ctgtttgatg cgccttgatc agcctgtaaa gctcgccgct 2740561 gtcagcgagc agatactgtt gaaccaacgt tttgcggtag gcgatcaatt ttttgagctc 2740621 atcaccctct ttttccgtga caactttctc atcaacaagt atatccataa tgtcgtcata 2740681 gctgcccggg tcccgcataa taaagccgtc aatcatgtca ttgcctgtat ccaaaatgca 2740741 ttcgattaac agatggccta tacgctgaag tgccaattcc ccgatttcag actgccagtc 2740801 tgtttgtgag tcaaatagcg ccagctggtg ctcgaagaac cctagtgttt tttcgatttt 2740861 gcttctgtca acaaaataca tgacagcatc ccctttgtgt atatttattt tctgatccgt 2740921 ttcaagacaa aatacgcaca gccgaaattg cagtattcgt aaatatattc atctaatgtg 2740981 ctgattttcg tttcgaaggt tgccttttga ttctggtcgt caaagaagcc cttgagcctt 2741041 aactgaccgt atccccagtc tcccacaata taatcgtatt tatttaatat atcggagtag 2741101 cgggctttaa aagcctcttc gttgaagccg tctttgaaat tgtgcaccaa ttcaaattcg 2741161 gcattttgaa taagaatcat gatctcacct cttttttcac tcattcctat cataattcat 2741221 tgccccgtcc ccatcaattg ctaaagaata aatcatgcga tttggctacc ctacacatga 2741281 ggagggattg ataaatgaaa cgaaccgctg tcagcctctg cctgctgacc ggactattat 2741341 ccgggtgcgg aggcgcagga ttggataatg cccaaaatgt ccggaatcag acgcagaatc 2741401 aaaccaaacc cattcatgtg tcggaccgca acgaggcttt taacaggcat aatgagaacg 2741461 aacaatttgg ctatgtccgc tatcaaaaag aacaatttga cggagaacag cagaaaacgc 2741521 cggtgatgaa ccgggaagaa accgctcaca tgatatcaag tttaacggtt cagctccccc 2741581 atattcaaga tgctgcgaca ttggtgactg accgagaagc gcttgtcgta tacaaaaccg 2741641 attctaaaaa ccgggagctg accgccgatc aggtgaaaaa aacagcggct tctgtgatac 2741701 cgcgatacta tcacgtgtat atttccgata atccaaacca tatgcaatcc gtcgaaaatt 2741761 acagcaatct cggctctggt tcaagggata ttagagagat catgtcgggg acgattcaag 2741821 aaatgaaaac ctccccgcaa ggaagccctg tctcagagaa tgaaaatgcc aatggagaaa 2741881 cgcgtcagga catgaaaatc gataggaatg acaaaaacgc cagatgatct ggcgttttgg 2741941 cattatgctt gtgcttgacg ctttttagat gcttcgttta cttgttcatc cgcatggtaa 2742001 gaggaacgga caagcggacc ggcttcacaa tggctgaagc ctttttgcat cgcgatttct 2742061 tttaattctg caaattcatc aggatggtag tatttttgga ctttcaagtg tttcttcgtc 2742121 ggctgcagat attggccgat tgccataata tccacgttgt tcgccaagag gtcgtccatt 2742181 acttcaataa tctcttcttt tgtttcgccg agtccgatca tgatacttga ttttgtcgga 2742241 atgtcaggct gcatttcctt cgcacggcgc aaaaattcca atgaacggtc gtacgtcgca 2742301 cgcgcgcgga ctcttggcgt caggcggcga accgtttcga tattgtgatt caggatgtct 2742361 gggcgtgtat ccatcaaggt ttttaggtta tcgtagtttc cgcccatatc agacggcagc 2742421 acctcaattg ttgtgaacgg gctttttctg cggatcgcac ggacagtttc cgcgaaaatg 2742481 cctgccccgc catctttctg atcgtcacgc gcaacagccg taatgaccgc gtgtttcaaa 2742541 ttcataagcg cgactgaatc cgctacgcgt tccggctctt gcagatcaag ctcagttgga 2742601 aggcctgttt tgacagcaca gaaacggcat gctcttgtac aaacagaacc taaaatcata 2742661 aatgtcgctg tacgtctgac cgcccagcat tcatgaatat tcggacactt tgcttcttcg 2742721 catacggtat gcaggttgtt ttcccgcatg agttttttga gccctgtata gttttcattt 2742781 gtatttaatt taattttaag ccattcgggc tttctgaggt gttcgtcttt ctttgccaat 2742841 tcccatcatc tccaatatcc aatatactca atttctgaca cgaaacattc tgaaaacgag 2742901 aaaggtgcag gttttagttc tgcaacaaaa ataatgtttt tctaactaaa gaaagtcttt 2742961 tctttagaca ctttaacata ggaaaaattt ctcgacaagg gaagatgatt actgacattt 2743021 ttaagccggg ttgccgcaaa ctatgtgtat tcaatatgaa aggagattat tttgtgaaag 2743081 ttttgttatc cgctcttctt ctccttttgt ttgcatttga gccttctgcg tctggaaaaa 2743141 aactttcaga tccagtgctg tcgaaacgga tggaattata tcataaaatc gaagctgtga 2743201 cgcagatccc ttggtatgcg ctcgccgctg ttgatcaata cgaagaaaac gtgcggagca 2743261 accggaaaga tctgcctgaa aaggcgggaa tcatcagcat ctatataccc gatgatatct 2743321 ggagcgggcc tgaaaacccg aatccgaaag acgatgcgcc gttaagcatt aaagtgtttg 2743381 acggaatcgg aatggatggc gatggagacg ggaaagccga ggtcagcaac gatgaagata 2743441 tcttgtatac gttcagccaa tacttactgt cgtatggcac agatgaagac aacatccgga 2743501 tcgggctttg gaattattac cggcgtgatc agacagtggg gattatatct gaattcatga 2743561 agctgtttaa agcctacggc catattgatc tgggcgagca tgcattcccg cttccgatca 2743621 gaaccgatta cagctaccga agcacgtggg gagatgcccg cggcttcggt ggaaggcgga 2743681 ttcatgaagg tacggatatc tttgcccatt acggccttcc tgtcaaatcc acatgttacg 2743741 gcgtagttga aatgaagggc tggaaccgct tcggaggatg gagaatcggc atcagggaca 2743801 ttaacaatac gtatcattat tttgcccatc tcaatgggtt tgccaaaggg attaaaacag 2743861 gacaaatcgt tgagcctggc caagtgatcg gatcagtcgg cagctccgga tacggcccgc 2743921 cgggaaccgc cgggaagttc ccgccgcatc tgcactatgg catgtacaaa gataacggaa 2743981 gaaccgaatg gtcatttgat ccatacccgc atttgagggc gtgggagcga tatgaatacc 2744041 aaaaaaagaa gtaacaaaaa gccgcctctt caacaggcgg cttatttgct gcttttttct 2744101 ttttttgaat cggcaccgtt ttctttgctg ctcggaagct ggacagaagg cgtgacaccc 2744161 gagccgccgc ttccattata aaactgcggc acttcgccct gcactgcttt aatcgataca 2744221 ggaacattat ttgtgacgac agcggttttg ctggcaaatg gaatgatgac cttcacttta 2744281 atttcgacaa agatgctgat atcaataagt gcgttattta tgccatacgg cttgattttg 2744341 gttttgacat ctgtaaaagc gtcaccgatt aaattgaacc ggaccgggat tttcggcccg 2744401 aggtttccaa gaaggctgtt gccggttacc tgtcccagcg gaatgttgat cataatgttt 2744461 tcactggcgc cgctgtgtcc ggtatgggtt tccatctctt tcaaatgagc ctgaagctgc 2744521 tttgtcactt ttgttttcac actgtttaca acctgtgtat taaaatcgat tgtcgttaag 2744581 tttccgtttt catcagaatt catttgaaac atatctttca tattttcact gtcagacata 2744641 tagtcctcaa tcgaatcctg gatcacctct gtcgctatac gcttcgtttc catctcgccg 2744701 atgtccatta aaacaggttt gatcgagcca ttgatcatcc aaaggctgac cgttgttgac 2744761 aggataaaaa agacaacgga caggagcatc acgtaacgga aaggcaaagg tcctctcttg 2744821 cgaaaagggc cgcgatatct tggcaagaaa atcccccctt acatatcaca atgtatgctt 2744881 gtaagagggg acatagtaat agccggggcc aatttatttt atttcatcat ttttaaaagc 2744941 gcttctctgc cgctcatgcc gactttgatg ccaagatctt ccgcagcgta cgtgacggat 2745001 tctaaaggtg cgtctaacag ctggtcaatg gtgcggacac caactgcgcg tcccgccacg 2745061 atgccgcgct cctttaattt ttcattcagc agcgccacat caagcgcgcc gcacataatg 2745121 tatccgtgat cattggcgac ggccataaaa ttcgttttgg gaagctttac tgtcacagct 2745181 gtaaaaggct gtccttctat catgatcggt gtcaggttta ccacgtcaac cactcccttc 2745241 attcatcact ttatgatgaa gggcacagct tgttgtgggc tgactgcctt attgtgcaag 2745301 cttccaagca agcagatccc gcaaaaattc cggcataaaa tattcttttt ctgcagcgtc 2745361 gcgaatcaac ggaaacagtt tgccgagcgt aaacatatca agcaccgcaa cggagtattg 2745421 tttatgtttt tcaatatctt ccccgttcag tgtgatccga gtgacgtggg tgatcccgtc 2745481 atcgagccgt ttcgtttcta cctcaacgcc ggcatacacc attttcccca tcacttctcc 2745541 gcggaagccg agtcctttga tccggagctg ctccatttgt tcggaagcgg catggacaat 2745601 ggtttccttc agttcttctc ccgtcaggcg gacagccacc gggttgatcg gatgcggaca 2745661 gatgcggtgc agatccagct ttgtcacagg acctgctttt agcggaccga gaatgacacc 2745721 tgaattgacc atactgatgt ccgtctcgca ccattccttt aaggcgtatg ccaaaagcaa 2745781 aggcagctct gattcttcaa accacttcac ctcagcatct tgtgcaagct ctgcaacggc 2745841 atcggacagt ttctcctcgg cttcacgttc tttttcattg agaaacgctt tagtttctgc 2745901 ggattctcct gtccattccg ccatgttctg cacagaagcc gttttgctgt tgatgcttcg 2745961 ctgtacgctg tccaccgtga tttctacaca gccgacataa tgcccgtatt tctcggcgct 2746021 ggccagcagt accccattaa ccacttgtcc atcttcgagc aaatgatggg tatgtgattc 2746081 gaggattaca tcaatctcag gcaccgcttc agccactgct tgatcatcaa gaatgcctaa 2746141 atgtgacagc agaacgataa tatcagcctg ccctttcact tccagaatgg tttcctttat 2746201 gctttcaagg gcatccgtaa ctgtccatcc cagcttgtca tatacaggat aatacggcac 2746261 agttacacct aagaaagcaa tggacatacc gtttttcaat gatttgatat ggtaaggcac 2746321 cgcccaggac ggacggtttc catttttatc aaacaggtta gagacgatga caggaaattc 2746381 agcatgatca tataaggcag caagctcttc atgcggaagc gtaatccctt cgttattgcc 2746441 gatcgccgct ccatcaatgt gaaggcggtt taagagatcg acattcgctt ttccgaatgt 2746501 cgcctctgtc acgaattgaa aacgatcaag atgatcgcca atatcaaaaa cgagcgtctc 2746561 ttcgccgtct gactgatgct cttttctttt ctgctcgata taatctacaa ttttcggcca 2746621 gttttcaaaa tggctgtgca aatcatttgt atgatataag cggagcttct ccttcataat 2746681 atctctccct aatcgttcag ctgaaaatgc cttcataaat gagctggcag ccgatcaaaa 2746741 tcaatacgat ccgcatgatc ataacgatcg ttttcgtctg catttttctg ttgatggcgg 2746801 cgccaagctt tccgccgaac caagcgccgg gcacaagcgc gagggcgtac agccaattga 2746861 cgtgcccgga aatcatatgt gaaacagacc ctgtcataga agacaggaaa ataataaaca 2746921 tggacgttgc caccgcaacc ttcggcggaa acagaaataa cagcatcatc gccggaacca 2746981 tcagtgatcc gccgcctata ccgaaaagtc cgcctaaaaa accgacaaca aaggcaatgg 2747041 caataccgac agaggcctga tatgagtacg tataaggctc accggcatca tcctgaaatg 2747101 tccggataat tcctttgtgc gctttgttga ttggccgggc tttcgctttc agcattaagg 2747161 ataatgaaat cagaatcata aaaatgccaa accaaacgga aaacgagttt gaattgaaca 2747221 gctttgacac gtaagccccg atcatgctgc cgggacccga accgataaag aaaatgagtc 2747281 cgctcttata atcaactgtt ttatatttaa tataagccaa agttgaagaa aggcccgtaa 2747341 aaataatgac caaaagcgaa gttccaatcg caacctgcgg cgtcacatcc tgaaacagct 2747401 gcgtcactgt gcttaaaaac atcagagatg gcacaatgac aattccgccg ccaagcccga 2747461 tcagacttcc taccgtacct gcgattaatc ccagtacgac caaaatcaca aacgacatca 2747521 atcaaaacct cttttctaaa ataaatcgag ctgtctcgga gcaagtccgc tgtactcgat 2747581 atcaagcagt tcaagcatct gcttgccatt atccgcagcg tcaccgccgg aattgttgtt 2747641 gaacaggaca aaaacatcct tacattgctg ctgcaattca ttcaggtgct ttttccaatc 2747701 ctccagctcc tgttggttgt agcggtataa gtacctgacc tcccgccagt ttttcccgcc 2747761 atcaggcttc atccagccct gcttgttgcg tccgtgaaac ctgacgagcg ttttgttttc 2747821 atcggtcgcg cgcaacacgg tcggaacgct gccttctccg atttgcggtt catcacagac 2747881 actgtgaatc cagccttccg ctttcataaa tgaaagcgtc tgctcataaa atggcggcga 2747941 gaaccaggaa cggtttctga attcaagcgc gcaaggaata tctcccattt ggtgcttaca 2748001 ccatctcaaa taggcgacat tctccttctt gcagtcaaac cacggcggaa attgaaacag 2748061 caccatggcg agcttattgc tatgtaaata tggcgttaaa gacaccttaa acgcatcaaa 2748121 catctcctct tttgagtcaa agggaatttc gccgcgctga tgccctgtca tgccctgata 2748181 tgctttcacg ataaattgga aggtttcggg cgtttccttc acccactttt cattattgcg 2748241 cgccggctga atcgcgtaaa agctcgcgtc taattccacg atcggaaaat gggaggaata 2748301 ggcctgcaat tttttctggc tggccgtttt cggcggatag atgctgtcat gatcccccca 2748361 tcccgtcagt ccgatataaa tcacactcat tcacctctct tccagtttat cacacgtgtt 2748421 ttcaggtttc ctcggaaatg ctgttcatat ggcgggaaaa tgcctcacgc aaatgctgat 2748481 attgttcctc attcgtatct aaaaacgcct cttctcttga ggaaggaatg tgctgatatt 2748541 caataggcgc ctgaaactgc tcactcgtaa aatcgtacac cacaccattg atgctgttat 2748601 aaaaatgcca gctctcatcg actcttgttt tgaaaatcgt gccgccgaaa tggtcttgaa 2748661 tcaccaatgc cgtcacgccg cattggccgc atgacgggca ttcttccgtc catttagagc 2748721 tcgaatggcg cgaccaggat tgcttaagta tgtatttgac atgctccatt gcctccgcct 2748781 cctttaaaaa aagataccac gttgatgaga ttttaaaaac tagaacggag gaaatcaaaa 2748841 aacccggcgg taaaatccgc cgggcttacg aaggaacgac cagagctccg tcaatttcag 2748901 tgactttttc cccatcattg tacacgcacc ggcctttgct gtaagtggcc gaaatgctgc 2748961 agggaaatgt atgtccttcg taaatgcttt ttttatgctt tgcaaacatc gattctcttg 2749021 taacagtgta cggctccatg ctgacgagca cgaaatctgc atcacacccc gcctcaagcc 2749081 gccctttttt ctgaaggccg aatcgttttg caggggccgc cgctgtccat tctgcgatgg 2749141 tttcaaatgg aatctgatgc tcaagcgcca gttccagcat tcctaataaa gtgaactgcc 2749201 cgccgctgat tccgccccat gataaaaaca tgttatcctc ccgcttcaag gatggacggc 2749261 aaggggaatg gtctgaggaa accatgtcaa tgtccccggc aatgagcgtc tcgatcagcg 2749321 tctcttttga ttgccgtgac cggagcggag gcgcgcattt tgcgacagag cccctttgcc 2749381 gtaaatcgtc atggctgaac aagacataat gcggacatgt ttcaaccgaa acatcaagac 2749441 cttcctgttt cgcctctctg atcagccgga ccgctttcgc cgtgctgata tggacaaaat 2749501 gaaccggaca gcctgtcacc ttcgcatact gaatcgtgcg atacaccgct tcaacttctg 2749561 cttcctccgg gcgggaggcg gcgtacgcat ccgcatccac ctttccttta ttggccaaaa 2749621 ccatctgcaa gtagcttgtg atcgcgtcgc tttccgcgtg gagagcgagg atttttcctg 2749681 cagccgcgat ttctgccatg cctttgagca atgtccgttc atcaacagag cggaactcat 2749741 cagtgcctga ctttgataaa aacgctttaa acccgatcgc tcccgcttca gccatcggac 2749801 ggatgtcctc gatatggcct ggcacaaggc cgccccatag cgcaaaatcc acggcagatt 2749861 tttgcctgcc tagctcagct tttgcgagaa gatgctctgc cgtcacggtt gatggaatac 2749921 agttgagcgg catatcaaaa taggtagtgc aaccgcctgc ggccatcatt tgagaacctg 2749981 tttcaaaccc ctcccaatcc tccctgcccg gttcattaaa atgaacatgg caatctatca 2750041 caccaggaaa cacgtatttc ccgtctgcct ggatgatttc cgtcccgctt gcttcaatgt 2750101 cagaacctat ctcggcaatg acaccgtttt gaactacaat atcagcttct ataacgccat 2750161 ctggcgtaac tgccttcgca ccttttatca ccatatcgta agccatattg atccccccat 2750221 gtcaggatga cgattttcca tgtcagttta tgtaacacaa ccagttctat tttcaacagt 2750281 ttactgctac tatgatcgta ttacatcagc aaaaccgcta gaattcctat tgaaaattat 2750341 tcaccttaac caatgttttt atagaaaagg agaatgcgct atgaatattc ttgatgtgat 2750401 gaaaataccg gcttttgaaa acgccaattt aatcgctgga aaagcaggag gggaaagaga 2750461 ggttcagcat gtcaatatga tggacgctcc ggatatcgta gactttttgc ataagaatga 2750521 attgctcgtc accaccgcct atcacctgaa ggatcacccg catcaattat ctgaactgat 2750581 tcggcaaatg gcaaaacgcg gctgcgcggg cctcggcatt aaaacaaagc gctatctgga 2750641 agatatcccg aaggaaatca tcgaactggc cgattcatat gcgtttccga tcattgagct 2750701 tccggaacac atccgactcg gcgatattgt gaatgccaca ctcagccata ttctcgatat 2750761 gcgttctaac gagctgcagc aagccattta cgcgcacaaa aaattcacaa accacattat 2750821 gagcggcaag gggctgcaat ccctcctcaa aaaggtgtca gacatccttc agcttcccgt 2750881 gctgctgctt gaccagcatg ccaaaatgct gtctgcgtct catcagattt cagttgagac 2750941 cgaaaagctg aaaggcaccc tgaataccgt atccgggcca tttttcactt gtttctctac 2751001 aatctcagat cagaaaacat attctgtcct gcctatttat aatcacgaaa aaaactgcgg 2751061 ctacctgctg atacccgaca tggtgcaggc aggcgacaaa ggattgatcc tcacgattga 2751121 acaagcggcc aacgtcattt cctttgaact gctgaaggaa aatgcgctga agcagttcag 2751181 ccggcgggcc cgcaatgagt ttttcaacaa ttttattgag cggacctttt cttcagatga 2751241 cgaaatcaaa aaccgggcga aagaattcaa gctgcgctgg gatcaaaaat acatgtgcat 2751301 cgccggcaaa ctcgatcgca atgacgaatc aatcagcttt acagaaaatc agctcgcttc 2751361 cgacagcgta ttcgaatttc ttgaaggtga attatcagcc ttcccgtttc cacctcactt 2751421 ctttatgaaa ggaaatgtcg gcattattct aatcgaggcg acagacagct ggagtgaaat 2751481 gcacgcctcg gtgatcagct ttttagaaca gtttcaaaca caggtcagcg ctcaatttaa 2751541 acgaaccgtg tcctttggca tcagcaatat ctgccaaaag ctcattgatg ttcccgacgc 2751601 tttcacagaa gcttctgatg ctctgcaatc ggggcatttg tcaagaagca ccgcatttat 2751661 ccaggtgtat cacgccaaag atgtgcctga gcttctgcgc ttgctcccag ttgaggattt 2751721 gaagaaattt tacaactcca cgcttcagag cctcgctgaa aaacagcagg aggatcaaag 2751781 cctgcttcat acgctttccg tctatttaga gacacactgc caaatttcag agacggcaaa 2751841 gcgtctgtac gttcatcgca atacggtcat ataccgcctt gaaaaatgcg aagagcttct 2751901 ggggaaaagc ttaaaagatc ctgaaacaac gatgcgtttg cggcttgcat tacgtatgca 2751961 gcggctgatc agctaaagtt tgttacattt tcttacaaaa cgaatcgttt ttcgtcactt 2752021 tcagcaatca cacctgtctt tttcagctac tgtatccaat gacacccctc gaccggaacg 2752081 atattatgtt actaaagttc acatacaggg agggactata gtgaaaaaaa gatcgtttaa 2752141 ggtgtttaca cttagcctgc agcatgtgct cgccatgtat gcaggtgcga ttttggtgcc 2752201 cctgcttgtc ggcagggcgc tgaatgtaac aactgaacag ctgtcctacc tattggcgat 2752261 tgacctgtta acatgcggcg tcgctacgct tttgcaaacc ttgcgcggaa catacatcgg 2752321 catcgggctt cccgtcatgc ttggcagttc atttgtggcc gtcaccccaa tgattgcaat 2752381 cggcagcaat tacggcattc acgcgattta tggttccatc attgcggccg gtgtgttcat 2752441 ctttttgttt gcgcgttttt tcggcaagct gactgtgtta tttcctcctg tcgtaacagg 2752501 taccgttgtg accttgatcg gcctttcact tgttccgaca ggtgtgaaaa atatggctgg 2752561 cggcgaaaaa ataaacggca gcgccaaccc cgaatacggt tcgctcgaaa accttcttct 2752621 ctctgtcggt gtccttgttc tgatcttagt cctcaaccgc tttctcaaag gatttgcccg 2752681 aacactgtcc gttctgatcg gcatcgccgc cggaacagcg gcagcagcga tcatgggcaa 2752741 agtcagcttt tcttctgtta cagaagcacc gttcttccaa atcccgaagc ctttttactt 2752801 cggagcccct gcgtttgaaa tcggtccgat cttaacgatg ctgatcgtcg gaatcgtcat 2752861 tattgtggaa tcaaccggcg ttttttacgc aatcggaaag atatgcggca gacctttaac 2752921 tgacaaagat ctcgtcaaag gctatcgagc ggaaggaatc gccattctca tcggcgggct 2752981 gttcaatgcc tttccttata atacctttgc gcaaaacgcc ggcttattgc agctgaccaa 2753041 agtgaaaaca agaaacatcg tcgttaccgc aggctgtatc cttgtctgtc tcggactgat 2753101 tccgaagatt gccgcccttg catctgccgt tcctgctgct gtacttggcg gcgcgaccgt 2753161 cgtcatgttc ggcatggtga ttgcctccgg cgtcaaaatg ctcagcacag cggatctcaa 2753221 aaatcaatac cacctcctga ccatcgcatg ctcaatcgca ctcggcatcg gcgccagcac 2753281 ggcccccggg atttttgctg aattccccgc tccgatccgg attctggtca gtgacggcac 2753341 catcaccgga agcctaaccg ccatcttttt gaatctattt ttcagcttgc gcgacaaaaa 2753401 agaattaaca gcacagcaaa cagaacttcc ggtattagaa catacactcg cattagaaaa 2753461 agaggtgtaa aaaagatgaa ggaacagcac aatgccttac agctaatgat gctggggctt 2753521 cagcacatgc ttgccatgta tgcgggagcc attctcgttc cgttgatcgt cggagcagcg 2753581 atcgggctga atgcggggca gctgacgtat ttaatcgcga ttgatttgtt tatgtgcggg 2753641 gcggcaactc ttttgcagct ctggagaaac cgatatttcg gcatcggcct tcccgttgtg 2753701 ctcggatgca cgtttaccgc agtcggcccg atgatttcca tcggaagcac ttacggtgtc 2753761 ccagcgatat atggtgccat tatcgccgca ggactgattg tcgtcttagc cgcgggcttc 2753821 ttcgggaagc ttgtccgttt ttttccgcct gtcgtaaccg gatcagtcgt catgatcatc 2753881 ggcatcagcc tgattccaac ggcaatgaat aacctggccg gaggtgaagg aagcaaagaa 2753941 ttcggctcac tcgacaacgt gctcctcggg tttggcgtca cagcttttat cttattgctg 2754001 ttttatttct ttaaaggctt tatccgctcc atagcgattt tactcggtct tatcgcagga 2754061 acagcggctg catatttcat gggaaaggtc gatttttctg aggttttgga ggcgtcttgg 2754121 cttcatgttc cgtctctgtt ttatttcgga ccgccaacct ttgagctgcc ggctgttgtc 2754181 acgatgcttc tcgttgcaat tgtcagcctc gttgaatcga caggcgttta ttttgccctc 2754241 gctgatatca caaaccgcag gctgtcggag aaggatctgg aaaaaggcta ccgggcagaa 2754301 ggccttgcga ttttgctggg cggcttattt aacgcgtttc cctatacagc tttctcgcag 2754361 aatgtcggca tcgttcagct ctcaaagatg aaaagtgtca acgtcatcgc catcacagga 2754421 atcatactgg tcgcgatcgg gctggttcca aaagcagcgg ccctgacaac agtgatcccc 2754481 accccagttc tcggcggcgc aatgatcgtc atgttcggca tggtcatttc ttacgggatc 2754541 aaaatgctat ccagcgttga ccttgattcg caaggcaacc tgctgattat cgcctcttcc 2754601 gtcagcttgg ggcttggcgc tacaacagtt cccgcgttgt tttcatctct ttcgggcgcg 2754661 gcctctgtct tggcaggaag cggaattgtg atcggcagtt tgacggccat tgcactgcac 2754721 gctttttttc aaaccaaaca gccgaatagc gcagacataa aaacgtaaag gaagatgcca 2754781 atgttcacaa tggatgacct gaaccaaatg gacacacaaa cactgacaga cacacttggc 2754841 tctatttttg aacactcttc atggattgcg gagagatccg cagcactacg gccgttttcg 2754901 tccctttctg atcttcaccg caaaatgact ggcattgtaa aagctgcgga tcgcgagaca 2754961 cagcttgatt taatcaaaaa gcatccccgg ctcggaacaa agaaaacaat gagcgatgac 2755021 tcggtacgag agcagcagaa cgcagggctc ggcaaattag aacagcagga atacgaggag 2755081 tttctcatgc tgaatgaaca ctattatgat cgcttcggct ttccttttat tttagcggtg 2755141 aagggaaaga cgaaacagga cattcaccaa gccctgctgg caaggcttga gagcgaacga 2755201 gaaacggagt tccagcaggc ccttatagaa atttaccgaa tcgcccgctt tcgtctggct 2755261 gacatcatca ctgaaaaagg agagacgcaa atgaaaagaa ccatgtctta tggcaaagga 2755321 aatgtatttg cataccgaac gtatttaaaa ccgctcactg gagtgaagca aatcccggaa 2755381 tcatcttttg ccggaagaga taataccgtt gtcggcgttg atgtgacatg cgaaattggc 2755441 ggagaagcct tcctgccatc atttacagac ggagacaaca ctctcgtcgt ggcaacggat 2755501 tcaatgaaaa actttatcca gcgccatctc gcatcctatg aaggaacgac aaccgagggg 2755561 ttcctacact atgtagctca ccgattttta gatacctatt ctcatatgga cacgatcact 2755621 ctgactggcg aagacattcc gtttgaagca atgcctgcat acgaggagaa agagctcagc 2755681 acaagccgcc tcgtcttcag aagatcgcgt aatgaacgaa gccgctctgt gctgaaagca 2755741 gaacgaagcg ggaataccat aacgattaca gagcaataca gcgaaatcat ggatcttcag 2755801 ctcgtcaagg tgagcggcaa ctccttcgtc ggcttcatcc gggacgaata tacgactctc 2755861 ccggaagacg gcaaccgccc gctgtttgtc tatttaaaca tcagctggca atatgaaaat 2755921 acaaatgact catacgcttc tgatccagca cgctacgttg cggctgaaca agtccgcgac 2755981 ttagcgagca ccgtttttca cgagctcgaa accccttcaa tccaaaacct aatctatcat 2756041 atcggctgca gaatattagc gaggttcccg cagctcactg atgtcagctt ccaatctcaa 2756101 aatcacacgt gggatacggt tgtcgaagaa atcccgggct caaaaggaaa agtctacacc 2756161 gaaccgcgcc cgccatacgg tttccaacat tttaccgtga caagagaaga cgccgagaaa 2756221 gaaaaacaga aagccgctga aaaatgtcgg agcctgaaag cctgatggga aaactgacaa 2756281 cccatatttt agatttaacc tgcggcaaac cagcggcgaa cgtaaaaatt ggattgaagc 2756341 ggctgggcga aagtattatg aaagaggtat acactaacaa tgacggcagg gtcgatgtcc 2756401 ctctgctggc tggtgaagag ctgatgtcag gagagtatgt gatggaattt catgcaggag 2756461 actattttgc gagtaaaaac atgaacgcag ccgatcagcc gtttttaacc atcgtcaccg 2756521 tccgttttca gctagcagat ccagatgcac attatcatat cccgctcttg ctgtcgccgt 2756581 ttggttatca ggtgtatagg gggagttaag aaggaagccc gcctcaccgg cgggcttctt 2756641 tttgcacttc aattaacttt tgatcctagg acagtacttg aagtgatccc cacacttagt 2756701 gaaacaacag ctagaataaa cattcaccta tatttttcag gataattgcc tacgagaaaa 2756761 ataccctgta gtcctttcat ttataaatcg aggtttcaaa ctaataagtc agctcttagc 2756821 agccgagctc ccttctccaa tcctataaac agaccgcgtt ttttctcgaa aaaatactct 2756881 gaagacaatt gctgcgtttt taatagtttt gataacgcgt tctctcttac acctttagac 2756941 aaaatattca ttttttcttt tttagactta aatctatgtc gaaaataatc gttggcatat 2757001 cttatcctat ctccactaaa ggaggtgaca ttatgggatt ctacaattct ggtggataca 2757061 gtggaaactc tggttactca aacggtttcg ggagctcctt cgctttgatc gtggtgctat 2757121 tcattttgtt gatcattgtt ggagcagcta tctttaatta ttaagtttaa ctttccttgc 2757181 ctccgccgta tccaacacct ccctgtccga cagacgccat aagaagtttt tatggcgtct 2757241 ttgctatgtg ttcactaatc tttttgtaat ccagaagctg tcaagttcta cgagatttat 2757301 cgtgtgtttt cccacaacgc ttctgcgtct tgatcgcgct gtctgactga ggctaaaaaa 2757361 gtccggcttt taaaagccgg actcccgtct acccccgttc aactctcttc taatcctgca 2757421 agctgaccgc ataatcccgc catacccggt acaccggcac aaattccccg ccagcccttc 2757481 ttctatatct ttgtcagaag gttgaggggt ttcccgaaac aatgctttaa gcgcaatgat 2757541 cattcccggc gtacagtagc cgcattggaa gccgccttct tccaggaaag cggtttgaca 2757601 catatccagc tcttcttttt gaagcccctc gatggttgtg atggaatggc cgtctgcttg 2757661 ataggccatc gtcatgcacg cattggccag ttttccgtcg attaaaatag agcaggctcc 2757721 gcagcggccg attccgcagg acacctttgt cccggtcagc tgaaattcct ttctaagcag 2757781 gtcactcaga tgtgtcgtag gaacggcagc aacctcccac gcctgaccat tcacggtcat 2757841 ccggaactgt tcctttttta caggaaatgg cccggcctct tttatgtcca ttgcttcagc 2757901 ccctttctgt cgatcgcttc aagcaactct tctcttgaaa ttggcagctt gtttatccag 2757961 catccgaccg catcatgtac tgcctttaca atcgccggag tgatggcgat tgttccgatt 2758021 tcaccaacac cgcgcggtcc atatacgtct cccttcatta agtcttctat tgcaatcagc 2758081 ttcatgtcag gaacatcttt gattccggga atcaaatagt gatcgagatt ttccgcagca 2758141 taacggccat ccgtcatttt cgcttcctcc atcagtgtgt agccgagtgc catggcagcg 2758201 ccgccttcaa tttgacctcg atatccctgc ggactgacaa ccggacctgc cgcaatagcg 2758261 tgctcacaat ctatcaattt gacatcgcct gttaacagat ctacctccac ctcaacggca 2758321 gccgctccaa atgagtagag gaaatggccg cccaccacag gatcaggcgt tgttggaaag 2758381 tcaaaggccg tttcctctgc caaagggcct ttttcagcca gctccttata cgtcaccacg 2758441 agcgcctttg tgtttttgtc acgcaagcct gcagcgccgg gaataagatt ttccgctgaa 2758501 cagccgctcc attctgccgc ccgttttttc aactgagcta gaaacggctt cttcaaacgc 2758561 tggatcgcgt gccacaccat gcttgtgccg cgggatgctg tggaggagcc tgacttcggc 2758621 acttttgcgg tatccccaat aacaatggaa atatcctctg cggcacaacc cagctcctcc 2758681 atgacaatct gttcaatcgc tgctagaatc ccctgtccgc attcttcaaa tccaaacgaa 2758741 gcagtgattt tgccttcact cgaaagagac aaacggcctc ctgccgcatc cattcggcca 2758801 aaccccagcc cgccgccgtg cattgtaatt gccgctcccg tgcctctttg cagatacccg 2758861 cagttccggc ttgttttttt aagaatggga gatttagata tggcattcaa cacctgtgcc 2758921 gctccgtcag ttggtgcaat tcgatgctca agcggcccca agtcatgcgg ttttctgata 2758981 ttttttcttc tcagctcgag cgggtcgatg ccaagcatgc cgctgagacg atcgagatgg 2759041 gtttcgagtg caaatgtgat ttggttgccg ccaaagcccc gaaattcccc cgccaccccg 2759101 ttgttcgtaa atactgatat tccttcagtc cggatattcg gaatacggta cggccccgcg 2759161 gcatgctcga cagaaaaatc aagaacagcc ggtccgagcg tagcgtaagc gcctgtgtcc 2759221 gccacaattt tcacgtcgtg cgccaataga tttcccgaat gatctgcacc cgtttttatc 2759281 gtaatcttca tcggatggcg cttaatgcca gaacgtacag attcctttcg tgtctgatga 2759341 attttgacag ggcgtccgct tttcagggcc aaaagcgcag catacggctg aatattcagc 2759401 tcatccttcc ctccgaacga gccgcccatc ggacttgaca caattctgat cttctcttca 2759461 ggaatatcaa aaatacgggc aagctggaaa cggtctttat agccgtgctg ggttcctgca 2759521 tacatcgtaa aacccccgtc gtcttccgga acggctacac ctccctccgt ttccatatac 2759581 gtatgcatct gccgcggcag ctcataggtt tcttcaaaga ctgtgtcaga tgcttgaaac 2759641 ccttcttcca catcaccgtt tgaaaaaaat gcgcggtgca ggatattccc gtcctcatgc 2759701 agtctttgcg cattcggccg aagcgctttt tctggtgaat ccatgacttc cagctcttta 2759761 tactcaactt gaatcagctc cagcgccgct tccgcgattt cttccgtttc cgcagcaact 2759821 gcggcgatcg catccccgac ataccgcacc ctgtcctcac ataaaaccgg ctgatcaggg 2759881 atgacaatgc caaatcggtt taagccggga acgtctttat gtgtgacgac ggcctgcacg 2759941 ccttccattt tctcagcttt tatggtgcaa accgacacaa tctctgcatg aggataagca 2760001 cttctcagca ccttgccata cagcattcct ggaaagctga gatcggtcat atatttcaat 2760061 tcccctgtga ccttacccct tccatccggc ctgactcttg acggtttgtt gatgatcatt 2760121 tattcccctc cctcagccat cagctctgcc atgatgacgt tggcagcggc tttttttctg 2760181 tatgccgctg acataaaaac atctgaggaa aacggcagct catggataag tgttttgtac 2760241 agctcatgcg ggtcccaccc tggtgccatc catttcgctt cgctgtccaa taatctccta 2760301 ggagtgatat cggcatggcc agcggcgagg cgaatgctgc cgtctttcaa aaaacgtcca 2760361 gctgcaacag cagccgctcc ggtaaaagcc tggcgccttc caagcttgtg ataaaataca 2760421 cgctctccct ccgcccgcgg gatgatgaca cgcgtgacga tagccgttct aaagtcttcc 2760481 tcactgagcc aagcgccaag cggcagcctg attagctcct tttgatatac gataagctca 2760541 gcaccaagca caagcagaag cggaatgaaa tcaccgattt tactcgctat gttgccgcca 2760601 atcgtggcac ggctgcgaat ccccggtgca gcgacagcgg aagcagcgtc actgaaacag 2760661 ctaagcgctc tcttaatcaa agggttcttt ctgcattcat tcagtgatgt gagccccccg 2760721 atcgacacgt gggtgtcact ggtgctgatc cctcgcattt cgtcaatccc ttcaaggctg 2760781 acaaggtgct gtttcggtag agttcctttg tcccactgaa gctgaaggag cgtgcttccc 2760841 gatgcggcac acacatccgg agcaagcttc tctaaaagcg aataggcctc atcaagcgct 2760901 gccggtctcc ataattgaat attcatcctt gcttttgtca cttggccgtt caagacatcg 2760961 ccctccttac catgtcatat tcctcgggtg tatcaatatc gtccaactca ccgctatcct 2761021 ttgcctccaa aaccgctcct gctccaagct gtccgctttt caggagcctg cgagcccctt 2761081 catctccctt taatcccttt acataaggaa aacatgtcga cgagaagtag attggcgggg 2761141 tgaacgcccc taaaaacgat gacacggcaa atgactcagg agccagagcc acaagggcat 2761201 tgagatgatc gacggaaagc tgaggctggt cggctaacaa aatgacaatg ccgtccgccc 2761261 ccatgctttc tgcttttctc accccgctgc tgactgaatg cccctgaccc ttttctgcgt 2761321 cttggcaaac gtgcaggctc cagcgttttt gaaaaggcgg agcgtgatac ggcgctccta 2761381 tccactcaag ggaggcatgt tctgtccgct cgacgaccag cacgtgatca aggcgggacg 2761441 acagagcagt tttcaaggaa agtgagccta tgttttctcc ttttagcggc aaagccagct 2761501 tgttttgtcc cattcttctg cttttgccgg cagcgagaaa cacgccgatc agataggggc 2761561 ttctcataca accgccaccc gttttcttgt ttgaatgatt tctgcaacta cacttaccgc 2761621 aatttcctcg ggaccttccg caccgatttt cagcccgacc ggactgtaaa agtgagacgg 2761681 aggatgtttt ccgctcagca gccgtttcgt gcggtttgcc gaacccaaca gtccaatata 2761741 atggaggttt tgagaaaata agaagttgat gatcgtttga tcgtgctgat aatgatgggt 2761801 tgccacaaca gctgcatcat gcggaaaaaa ttgaaattcg ctaagcattt gttccggaaa 2761861 agcggtgatc agctgatccg cttttggaaa aagagaggat gtacaataag cgggccgcca 2761921 atccgtcacg ataacagaaa accctgtgtc agccgccaaa ttggccagcg gtacattatc 2761981 cggtcccgcc ccaaacagaa tgagacgcgg cttcggttca attcgctgaa taaacatgtt 2762041 agtggtttga tcgaaatgcg gtaaatgaag cgttgaaaca gtacgttgaa tatcttgcag 2762101 aggcgcgtcc ggccagttcc caaaatgtcc gttctccgtc agaaataaat aatgggagga 2762161 ttcaatcttt ataacggaag tgacagcttt gcctgaatga aggcagtccc tcactttctc 2762221 atagtgccgc cttttttcct gagtgattcg ctctgcatga acatgaataa tgccattgca 2762281 cccggctccc atgccccaag aaagatcgtc ctccgaccgc atgtcgtagg gaatcagcgt 2762341 tgatgtgagc tgatcgccca gcgcactgat tctttggaat acatcttctt ccacacaccc 2762401 gccgctcagc aagccaatcc gtctgccttt tttcttaaag agcatagagg cgcctgcttt 2762461 tcgatacgcg gagccttcaa cttgaacaat tgtcgccagt acagcctcct cctggtcttc 2762521 caggagcgca tctaacatcg tgtgaaaatt ccccaatgcc gcatcctcct ctcgaaaatt 2762581 gccgtgagaa acaactagtt cagcgtgatt ttataggtaa cttgtataaa gaatagacga 2762641 tggaagaaaa aatgactcat gatttgtcag aaaatgaaac acatagaaag aggatttgta 2762701 aaaagagtca aacgaagaaa atcagattgg agaaaacacg aaatcatatc gttaaaaagc 2762761 ttgcggagtt ccgcaagctt ttctttacac cgctgcctgg cggccagcgt tttcatacac 2762821 atccagcgct gcttggagcg cttttcctgc ttcgattcct gcgttatgtc tgagaagcac 2762881 agcctctaac ccggcaagca cgaatagcac gttttctttt ctgcagctgt accccatcgt 2762941 gccgatcctc cagatcttcc ctgcaagcgg gccgaatgag ctggcgattt caatgccgaa 2763001 ttgtgccagc agcatgtcac ggacagactc gccgtcaatg ccgccgggaa tttcgacaca 2763061 ggtgacaaca ggcattttgc agctgtcatc tccaaacaat cttagcccca ttgcctttat 2763121 ccctgctgct aatgcggctt catggtgccg atgccgctcg aaacgcgtct caagaccttc 2763181 ttcaagcacc agtctgactc cctcacgtaa ggcgtacagc atcgtcgtcg cttctgtatg 2763241 atgattgagc cgtctttcgc tccaataatc ctcaagctgg ctcaaatcaa agtagttgct 2763301 tgtaattggc cgatttcccg aaagtgctgc cctgtcagct tgtgtcgcaa tcccgcgttc 2763361 cacctttttg cgagctgcaa tcacgtccgc cacccgctca ttatatgtaa tcggcgccat 2763421 tcctgaaggc acagacaaac atttttgcgt tccgccgatg gcagcgtcaa tcttccattc 2763481 atcgacttta acctcgcagc ccccaatcgt tgcgactgca tcgacgataa acaatgcatc 2763541 ctcggtgcgg caggcttcgc cgatggcttt cagcgggtga atccgtcctg tcgatgtttc 2763601 tccatgcacc atggccacaa ttttcggctt cacttttttt atctcccgta tgatgtcctc 2763661 cgggtcaaaa accgttcccc attcgcactc cagcatatga acatttgccc catatcgctc 2763721 ggcgatttca gtcagcaaat aaccgaaacg gccgtaaatg ggaatgagca catcatcttc 2763781 cggctctatc acactagcca gcactgcttc aattcccgcc cgtgaagtgc cgtcaatcgg 2763841 gtatgcccag cggttttttg tttggaacag ctcccgaagc atctccatcg tttcattcat 2763901 aatacctgta aacgccggat caaattggcc gacaaccggg gtgctcatta ctcttaatac 2763961 acgcggatca acctcaacag gccccggtgt cataatcgtt cttaacgggg tgcataattc 2764021 tcttctgcct gacacagcca ttcctccttt atcagtaagc cagtttgtat aataaatcag 2764081 tcagtgcgcg gacgccgatc tcaagctgtc tggctgacgt atattccttc ggtgagtggc 2764141 tgacgccgcc tcggctcggc acaaacagca tacaagcagg atagcgcctt ccgatcattt 2764201 gcgcgtcatg ccctgctccg ctcaccattt cctcacagct gaagccgttt tctaatgctg 2764261 tttcaaaagc cgcagccttc agcctttcgt ccatcggcac aggctctatc cgcatatatt 2764321 catcaatcac agcgcgaatt cctttttgta ggcaaatgcc gttgatcaaa gcaaccatgt 2764381 cttgatgaaa ctgttccagc acatgctgat gctgatggcg aatatcgatt gaaaactgga 2764441 cgcggcccgg tatgacattg gctacattgg gctctgccgt tatttttccg catgtcagac 2764501 ggagctcatc cggcagctca tccgaccgca gcagcagctc atgaatgata cggctgctgg 2764561 ctgcgagcgg gtccttgcgc catttcatgg aggtggttcc tgcgtgattg cattctcctt 2764621 cgagcgtgac gagatatcgt ctctgccccg caatacttgt cacgatgccg agatcccggc 2764681 ctgacatttc caacgtcttc ccctgttcaa tatgcagctc aacaaacgcg ctgatatctg 2764741 tcctatatgc tgactgaaac acacctttgc caaaaccgct ctcatgcatc gctgtttgga 2764801 gggagactcc cgactcgtct cttggctctt ttgcatcttg ttctgaaaaa acacccgtca 2764861 tattccccga cccccaatag gtcattggaa aacggctgcc ttcctcctca cataaggaga 2764921 ccgcctcgag cgtttttttt ggcgctccgt atgtttcctt gagctgcttt aacgcgagca 2764981 ttgccgccag aacgccatag gcgccgtcgt attttcctcc attgatgaca gtatcgatat 2765041 gtgaaccggt tacaatgact tcatccggag actgggtgcc cgaaagcctt ccaaacacat 2765101 tgccgacatc gtcgaatctt gtttcaagcc cgaaagaaga catttccgtt ttcacagcaa 2765161 gctgtgcgtc catccactct tttgtgtata aaagcctcgt tacgccgcca tccgcagacg 2765221 caccgtattg ggcgagccat tcaatataat ctgtgatgct gttttttact gaaagcttct 2765281 gcttttccat gtactccccc ctctggccgc tatggtgact tcattataga aggagcaaca 2765341 tgatagttca ttgacagatt aaccaaaaaa acgtttattt tttagccaca gtatccatcc 2765401 agcaaccaga tacaccctac atgtcacaac tattttgatg taaaggtcaa aagaaaacac 2765461 ggtaaggaag agagccagca agagcgaaag agagggtcaa aatgcctttc atatgaacaa 2765521 gctaagctgg agaggcgatg ttcgcggaac ggatgaaaac agaaatgccg gcagcccgca 2765581 aaaacaggac ctaaagatat ggaaacagga gatttccgcc tcctccaaag ggactaattt 2765641 acaattttaa tgaaaaatat acaaaatgac acttctatcc tttatttcaa ttttagataa 2765701 tagatatgat ctgataaaag gagggcaagt gatgacaaaa aaagcatggt ttctgccgct 2765761 cgtctgtgta ttactgattt ccggatggct tgcgccagca gcttcagcaa gcgcgcaaac 2765821 cacattaagc cttaatgacc gattggcgtc ttccccttca ggaacgggaa gccttctctc 2765881 attagccgcc cccgctgcac cctatgctga cacagatacc tattatgaag gggctgaagg 2765941 taaaacagga gactcgctaa aaagcaccct gcaccgtatt atcagcggac acacgatgct 2766001 gtcctacagc gaagtgtgga acgcgctgaa agaaacggat gaagacccaa gaaatccgaa 2766061 taacgtcatc ctgctctata cgaatgaatc gcgttccaaa aacctgaacg gcggcaatgt 2766121 cggcgattgg aaccgcgagc atgtctgggc gaaatcccat ggcgattttg gtacgagcaa 2766181 gggacctggt actgatattc atcatttgcg cccggctgat gttcaagtta acagcgccag 2766241 aggaaatatg gattttgaca atggcggcac tgaatatgcg aaggcacccg gaaattatta 2766301 tgacggcgat tcatgggagc cccgcgatga tgtgaaaggc gatgttgccc gcatgctgtt 2766361 ttacatggct gtccgttacg agggtgatga cggctatcct gatcttgagc ttaatgataa 2766421 gacaggcaac ggctcagctc cttatcatgg caaacaatct gtcctgctcg aatggaataa 2766481 gcaggatccg gttgacgacc gcgagcggaa aagaaatgaa atcatttatg aaaaatatca 2766541 gcacaaccgc aatccattta tcgaccaccc tgaatgggcg gatgagattt ggccgtaaga 2766601 aaaaggtgct ccttttgagg agcacctttt tctaatacac agcctcttcc gtttccgcat 2766661 cgaaaaagac gacgtggtcc attttcactg agagctggat tgaatcgcct gcatcgattc 2766721 gcgtgtttcc gtccaggcgg accttgagcc gctcgtcccc agccatgaca tgcactatga 2766781 gctccgagcc cagattttca ttcacttcca cgttcgcttg aaacactgaa tcaaacaact 2766841 ggtcatttcc tgtcatttgt gtgatgtgct ccggccgtac accggcaatc atctgttctc 2766901 cggcatatcc cttttccttc agccgctttg ctttttcttc aggaatatga agccggatcg 2766961 aagaatttgt gaaaaacagc tcgccatgct gctgttctat gatgcctttc aaaaagttca 2767021 ttccgggaga gccaatgaag cctgcgacaa acaaattggc cgggtaatga taaatgtcat 2767081 gaggtttcgc cacttgctga atttcccctt cattcatgac gacaatccga tctcccattg 2767141 tcattgcttc ggtctggtca tgcgtgacat aaatgatcgt tgcctctaat cgctggtgca 2767201 gcttgctgat ttctgtccgc atcgtcactc ttagttttgc atccagatta gaaagcggct 2767261 cgtccattaa aaagaccttc ggctccctca caatcgacct gccaagcgcc accctttgcc 2767321 gctgcccgcc ggagagcgcc ttcggttttc tcttcagcaa atgttcaatt tctaaaattc 2767381 tggctgccgc atgaacccgc tcggcaattt cctgtttcgc catctttctg agctttaatc 2767441 caaacgccat attatcaaaa accgtcatat gcggataaag cgcatagttc tggaatacca 2767501 tcgcaatatc acgttctttc ggcggaagat cattgacccg ctccccatca ataagaagat 2767561 ttccttcaga aatgctttct aatccagcca ccatccgcag cgttgttgat tttccgcatc 2767621 ctgacggccc caccagcacc aaaagctcct tatcctttac atctaaatca aagtccttca 2767681 cggttaattg tgagtgatat gattttttga cgtgttcaaa tgttaatgaa gccatcagaa 2767741 aagtccccct atcttttgac ccgttatttc gtcactggaa acaacttggt ctttctgtta 2767801 tttttagagt aatcgattcc catttttgct atatttctaa aataaaaaat gtaaatttgt 2767861 attataacgt cataatacat tataatataa ataataggtt aaaaggaggc taccctttgt 2767921 taaacaacgg aagttctaca cctttataca ttcagctaaa acaaatcatc actgatgaca 2767981 tcaaaaaggg cgtgtattcc ccaaccgcca agctgcctac cgaaaacgag ctttgcacca 2768041 agtataacgt cagccgcatc accgtcagga aagccattct cgatttagtc gaagaaggct 2768101 atctgatcag gcagcaggga aagggaacgt tcgttaaaag ccctaaatta aaacgagagc 2768161 tgatcgctgt aaacggctac tcggaattta tggaatcaac cggcaaaaaa ccgaagcatc 2768221 atgtgctgtc ccatgacatc attccagcgt caaaacccat cgccgaaaag cttcaaatcc 2768281 aacccgagag ccctgtggtt gaattaaaac ggattttata taatgatgat cagcctctca 2768341 cctttgaagt gacgcattat ccgcttgatt tgtttcccgg cattgatacc tttattgctg 2768401 acggcgtctc catgcatgat attttgaaac agcaatacaa agttgtaccc acgcacaata 2768461 cgaagctatt aaacgttgta tatgcccaac aggaggaaag caaatacctg gattgtgata 2768521 tcggggatgc gctgtttgaa attgataaaa cggcttttac atcaaacgac cagccaatct 2768581 attgctcatt gtttttgatg cacacaaacc gtgtcacttt taccatcaac agcccctaca 2768641 cataacaggc ataaaaaacg agacactgct tatagtattc tcgttttttc actgcttccc 2768701 ccgtcctcca agcgataagg atagccatag ccgaaagctc cgtacacacc gcaagttttc 2768761 gcagccgttt cagcagcctg gcgcaaagca tacgttatat cctgcttcac gcaaaaggca 2768821 gtcaaaaagc ctgctataaa agaatctccc gctccaagtg tatctattat atcagcttcc 2768881 acaatcggct gatgatagac tcgatcaccc gcagacagga ttgctccttg gccccctcgg 2768941 gtcatacaaa ccattttggc tccgtaccca tgagctgttt tggcaagctc accgcattcc 2769001 gactcactca aatcgcttcc tgaaaaaaac gcatacgtca cataaggaca gaccctcctc 2769061 aaataatcat cctcccgatt ggttgaaaaa tcaaatgaga ccgggaccag cccgcacagc 2769121 tgcggaagat cgttctcaag cctgctgtac acgctcgtat gcagcagatc atgcccgctg 2769181 ataaaagata catctttctc ctgaaacgcg aggcgaagcc gggactgaat gccgccttta 2769241 tttgatctga caaaaatgcg gtccccctgt tcatcaaggg tgacaatcgc catcccgttt 2769301 tctccgtgcg cctggcggat ataatctgca ttgacctgct ccagcttgag aacgttcaac 2769361 agatgcgccg cggcttcgtc attgccgacg attccgatat aggaagactc atgcccgagc 2769421 cgcttggcaa gcacagcaac gtttaaggca tttcctcccg ggtaaaatgt ttcttgatcc 2769481 tggtagtaat ctacaacatt atctccaacc gcaatcaatt tcatagcgct tcctccttta 2769541 tccttttaca ctgccgcttg caatcccgcg gacaaaatat ttctgcatca ataaaaatag 2769601 aataataatc ggcgcggctg aaatcgttaa ccccgccagc aggacgcccc agtctgtctg 2769661 cagcgcgtct ctgaactgca tcagcccggc tggaatggtc cgtaaattct catcatctat 2769721 gaaaataatc gcaaacataa actcattcca tgtatggtaa gccgtcaaaa tgccggatgt 2769781 caccaaaatc ggcacgctca ttggtaagaa aattctgaaa aatactccaa aacttgtaca 2769841 cccatccaaa taggccgcct cctccaattc ttttgaaata gaaagaaaat aagagcggat 2769901 caaaatgatg gtgaatggga tccgataagc cgcatacggc aagattaacg cccaatacgt 2769961 attgtacagg cccagcgact gaataataga ataaagcggc acaagactga cctgcggcgt 2770021 cagcatcaat ccgccaagac atagcaccaa aaagaatcct tttcctttaa actcaaaccg 2770081 ggaaaggcca tacgctgccc atgcactgat aaagacagtg atcacacacg tcagcgccgt 2770141 aacgatgaca ctgttcataa aataagaaga aatcccctga ttccaggcgg aaacaaaatt 2770201 ttccggatgc cacgaagacg gcagcgacca gctgtgctca aaaatatcgt cagagttttt 2770261 aaaggcgctc atcaccatcc agagaagcgg ataggcaatc gcaatcagat aaagaaacag 2770321 aaaaacccac acagacgttt ctccgatata ccattttcgt ctaggcttat ctttcacctc 2770381 aatgtgctgg tcaggcaccg gctccaatct gaacgaatct gtcttcttct gaggcagcat 2770441 cagttactcc tcctttccgg ttttaaagaa cttcatttgc atgagcgata atgcaagcgt 2770501 aatgattaac acgacagtgg caatcgctga ggcgtagccc atcatatcct ttgtaaaggc 2770561 gcttttatat aaaaacgtgc tcaagacttc tgacgctttt cccggcccgc cgcctgtcaa 2770621 aatgtacggc tcattaaaga ccgtaaaggc tccggtcagc gtcatgacca ccgcaacaaa 2770681 agacatctct ttcgtctggg gaacagtaat atgaaaaaac tgctgaattt tacccgcgcc 2770741 gtcaagccgg gccgcttcat acagttcatc cggtattttt tgaatcgaca cgatgtacag 2770801 catcgcaata taaccgacag attgccactg ggacacaaaa atgacagaaa gcatagctgt 2770861 gctgtcatcc ccgagccagg ccctcgtcag ctgatcaaga ccgatggcct gaagcagctg 2770921 attcaaaagc cctgtctccg gattgtaaat aaaatcaaac aaaagcgcga tcaccgtcat 2770981 tgagatgaca accggcaaaa agaaaacggt acgaaaaaac ggcgaccatt ttctgaccag 2771041 cttatcctca agcaccgccg ccaaaatcaa accgccaaat acctggcata caattgagat 2771101 cactgcataa agcacattat tggtaagtgc ctgatagaag acaggatcat gaaataattc 2771161 aacatagttt tttaagccga taaacgtttt ttccggagaa aatgagctcc actgaaacag 2771221 gctgaggaat acattctcaa aaatcgggat ataaacgaaa agtaaaaaaa cgagagcggg 2771281 caccaaaaac aaatagggga ttattttatt ctgattgacc aagggtatct catctccttt 2771341 ataaaaagaa aaggtgcgaa gcttcacctt ttctttgatt tattcagctg acgccctcac 2771401 ctgctttgct gccttttgaa cggctttcat cacctgctgc ggtgtcatgt cgccgccaag 2771461 catttgctgg acgcccgtta ggtacgcatc tgcgacttca acatcgacat ccatatcaaa 2771521 ccatggaacc attgatttgg catcaacaat atgctgaacg gcttcacgct gaatggctgt 2771581 tgcattttct tcagtagccg taccttgcac tgcactgtat ttcccgacat ctttcacgag 2771641 cttttcgccc attcttttcg acgtcaagaa ctgcaaaaat tccatcgctt ccttcggatg 2771701 ttttgttctt gaggagatca tgaatccttc cggcgctccc gttaacgctt ctgaagatcc 2771761 tttctgcccg ctgatttcag gaaatgggaa catcccgaga ttaaccggtt caaccagctt 2771821 gatttccgct gtttccgcat atatcatcgc cgactttccg ctcttaaatt gctgtctcac 2771881 atattcgtgg tcgacggagt ttacatgttt attaaagtaa ggcatcagct cttgaagctt 2771941 ttcaagtgct tttacgtagc cttcatcagt aaattcaccc gttttggcgt tatagtcctt 2772001 ttcccgtgtt ttttcatcga ccatccgctg attaagcgtg ccgatatagt gcgagattgt 2772061 ccaagtcgcc tttgttccaa agctgatcgg tgtgtagcca tgttctttca gcttttttga 2772121 cacatcgatt aattcatccc acgtcttcgg gggatcaaga ttcagctttt ggaaaatgtc 2772181 tttattatag aagaatgatt tagcgtccat ttgccacggt acgccatatt gcttgttttc 2772241 ataagtaaat ggtgtaattt gcgattgaac gagctgtgat gaccaatcgg tgtcattttt 2772301 gtagtaggac gagagatcaa gtgctttatt gcctctgata aatttaaaag caaactcatc 2772361 gctccaagag aagtaaatgt caggagggct ggtggttccc agcatgacct taattttatc 2772421 tttataggag tcatttaaaa cggcttcaat ttgaatgtcg atatctgggt gatctttttc 2772481 aaattcctta acaacctctt caaaataact tttttccggc tcctttggcc atctgtggaa 2772541 aaatttcaat gtcacctttc cgtccgctga actgctttgg ctcgaacagc ctgcgatggt 2772601 gagcatactg acagctgcaa tgatcaagaa caacaacatt ttcttcaaag ggttggcctc 2772661 ctctggacat tagactataa tgttatataa cattatagtc taatgcataa tggttcttca 2772721 ttttcagatc aatactcaac tttccacatg tatcttctat gagataaagg atgatttctc 2772781 tcctctgcca gctcgtctgc atagcttctc agcacacgat tgagaacgag cggagcaaga 2772841 tagcctttaa ctgaatcgtc aattgcagtg aagtcgtaag atgcagcatc aagcacagtg 2772901 agctttttgc catacttttt cgagaaggta agcgcccgct cttcaagagg tcttgtttca 2772961 tctaaaccga gcaggatgat aaacggcacg gattcatcaa taatttcaaa cggtccgtga 2773021 aaatattctc cggcatgaat ggcgtgggaa tgaatccatt gcatttccat gagaatgcag 2773081 atgctgtagg agtaagcgac accgtagttt gcaccgcttg ccatggtata aataatgctt 2773141 tctttttcat gggcttttgc aaattgcttg gcgttgtcag cttcctgctt aagggctttt 2773201 tcatatacag cctgcaattg atctaagcct tcaattgctt gctcaaattt cgtattgttt 2773261 tctaatactt gcagggttcc aaaaacgatt tgatacaaaa cgccatagtt tgtattgatc 2773321 gcaagcgcct catcacccca atcgtactgg gcaacatatt gcgcttcctg cgctaaagga 2773381 gactccggtt taaacgtcat cgcaatcgta agtgcgccct tgccccttgc aaacgcagca 2773441 gctttgactg tctccggggt atttcccgaa tgcgagcaca aaataacaag agacttttca 2773501 ccaagctgaa cagggttgcg ctgaataaat tcgttggcgc tgtagagatc ggagtttatt 2773561 gattttgact ctctgtcaaa cacatactta ctcggataca taatggcaga agaccctccg 2773621 catgcgacaa agaatacatg atcaatggtt ttccctttca aatcctgcaa gaaagcttga 2773681 acctcacgat ttacttttgc tgtggcctga ctcaaatcct tcactcctcg tttttattat 2773741 ataacgttat ataacattat atattgttat attaaagtcc gcgggtagga ttgtcaatat 2773801 tattttctga aatttctcaa taatttattc ggatgacaga caaagggtct atatgcgaaa 2773861 aaatgcccaa atcaaaagcc agaacttgac ttaagctctg gcttcgctgt tcaatccgca 2773921 gactgacgtc ttatttaaaa aataccttgt ctatattgta cttcgagtgc tgtgtattga 2773981 tgatatatgt ttcgtaaatc tctctttcca ttggatcatc aactacacat acctcaattt 2774041 tataaacttc atctctgtga tgtttgatcg gtgaaacagt gtcttcgaaa tgcttcttaa 2774101 ttctctgtct taactttctg gctttaccga caaacagcag ctcgtcatga atgttgtaaa 2774161 acataaaaat gccgcctttg tcccttggga tctggtgaaa gtcgatgaat ccgtgaatcg 2774221 gttttatctt cggctcgtta tcattagctg actgctgtcg ttcagtgatg gtgacattcg 2774281 gtgcgggtat atcaattttt atcaaaatca gttcacgtcc tctttttcat taaagataaa 2774341 tgctaacaca tacagaaaag aaaagctaga acagctttat tatatttgtt tgtcatgctc 2774401 ttacttatta tgcaagtgct ccggctggat cataaggact aaggtctaat tctgtctgct 2774461 ttccgagaac tagctttgcg agctctgcac ccaaaaacgg ccccatcgtc agtccagaag 2774521 cacccaaacc gtttgcagcg tacaggcctt gaacattcgg cacggcccct acgaccggca 2774581 gaaatcccgg tgtaaacggc ctgaagccca ctcttgtttc aacagcagcc gcatcagcaa 2774641 gacccggtgc aacggctaac gctttgctca atacttcgtg ctggcctccg gctgtcacac 2774701 gaagatcatc aagaccggca tcgttttcgt gtgtggcgcc ggctacaatt ctgccgttat 2774761 caaacgacag aatgtactga tcactcggcg gcattacaac cggccacgat cctgtatctg 2774821 catctgtcat ttcaaaatgc ataatctgcg ctttttgaaa tgacacttga aaatgaatgc 2774881 caagaggctt caatatctca ttggcccatg ctcccgccgt cacaatgacc gcgtcagccg 2774941 caaactgctt tgtatctgtt tgcacgccgg tgactgttcc gttttcaaaa agcaaggacg 2775001 catttccttt gatgaccgtt gcgccgcgtt tctctgcagc gcttaaaagc gaccggcaca 2775061 gcgctcttcc gttcacacgg gcggcaccgc tgatatgaac cgattcatag ccgtcagcta 2775121 aaatcggaaa cagctttttc gtttcacttg cagacaagcg ggtaatgtcg ccgatttccg 2775181 gcgcatcctc ccgtctctta tacgcccttt cctccatttt atcgagttta gacgcgtcag 2775241 tatgaatgct gatggcaccg acacgtttgt atcctgtatc cgattcaccg tctttttcca 2775301 attgatggat taaatcctta tagtaccgcg ctcccccctt agcaagctgg taccaatcct 2775361 gattacggcg ctgcgagagc caaggacaga cgatccccgc cgccgcatca gtcgcttgtc 2775421 ccggctcttt ccgatcaatg acagtaacgc gagcgcctgt ttttgcgaga tgataagccg 2775481 tcgacgcgcc cagaatccct gcgccgacga tgatgtacga tttcatatgc aaacaccttt 2775541 tctattataa tgtctattca ttttaccaaa tcaaatgctt tccttcgacc ttttgcccta 2775601 atgtggaaaa accgcgaagt tcgtccaatc tctttactct cctatcgaat atcctgtcac 2775661 tatcaataga gaaaggatga taccatgagc gaaaatcgtc atgaaaatga agaaaacaga 2775721 cgcgatgcgg cagtggcaaa agtccaaaac agcggtaatg caaaagtcgt ggtcagcgtg 2775781 aacacagatc aggatcaggc acaggcgcag tcacaagacg gagaagacta atgaacgaaa 2775841 acatcattcc tcttaacaga catactcaag agatacccac tactgaatct gttatcaaaa 2775901 acagcggcaa ctcagaggtc catatcgaca ttcacattga tacaatgcca attgcttttg 2775961 ctatattatg ctctgcatta gccgcaaagc agatgacaaa agaggaattc gatatggctt 2776021 atactcaatt gcgagagatg aacagagaaa ataacagcag atcatctgta aagcaaatta 2776081 tcaatcaaga gacagaagaa gagtaaaaaa ccgcggcccc tcggccagcg gtttttcttc 2776141 tgcatacaaa aaggacgcga ctgaatcggt tacttctgta caatttgaat aaggttaccg 2776201 catgtatcgt cgaagacagc tattgtgact tcgcccattt ttgtcggttc cgtcgtaaac 2776261 gtcacgcctt tttcctttaa tcggttgtac tctttttgaa tatctgcaac gccaaacatt 2776321 gtggccggga ggccttcgga gaatatcttc ttttgatact ccttggcggc aggatgttca 2776381 ttcggttcga gtaaaagctc ggttccgtct tgatcatctg gagaaacaag cgttatccac 2776441 ctgaatttcc ccatgggaac gtcttccttt tttataaacc caagtttttc tgtataaaac 2776501 tccagtgcca tgtcttgatc ttgtacaaat atactggtaa caacgatttt catactgttt 2776561 ttccctcctt cgatatgaat gaagcatggt actatgctaa caatctggct acaagcaaaa 2776621 caacccacac atttatcaga ggccctgttc tgattttata aaattattct atccatcctt 2776681 tcagcaaatt tttaagcggt tcgttgttga atataagtac tcgatatttt ccctttcgtt 2776741 ttgatgttac gagtcctgca tcctccagta cagaaaggtg tttagctatc gcctgtcgcg 2776801 taatagaaag gtcgtacttt gtaataagac gtatcgtaag ttcatacaac gtcagctcgt 2776861 tgcgttcaga taattcgtct aatataagcc gccgagtcga atcgccgagt gctttgaata 2776921 tagcgtcttt gttcccattc atatattgag tataagcaac ccattagttg catgtcaagt 2776981 ataagcaact gtatggttgc gtgatataga aactgaacct atccggcgca ggtctgaaat 2777041 attctaatcg ataaggaatt aaaaccatta aaataacagt ggatatgtct ctgaaaaata 2777101 aaagaagacg aacttcaaaa gttcgtcttc tacaatcaaa ttcggcacgc cggccatttt 2777161 aaagttgata actatctcta aaccccttga taaacaaagg agttttcatc attaaccgat 2777221 agaaccttcc atttcgaact taatcaaacg gttcatttca actgcgtatt ccatcggaag 2777281 ctcttttgtg aatggctcga taaagcccat tacgatcatt tcagttgctt cttcttcaga 2777341 aataccgcgg ctcatcaagt agaagagctg ctcttcagat actttagaca ctttcgcttc 2777401 gtgctccaat gaaatgttat catttaagat ttcattgtaa ggaattgtgt cagaagttga 2777461 tttgttatcc ataatgagcg tatcacactc gatgttagag cgggcgcctt ccgctttgcg 2777521 tccgaagtgg acgattccgc ggtacgttac ttttccgccc tgttttgaaa tcgattttga 2777581 tacgattgta gatgatgtgt ttggtgcaag gtgaatcatt ttcgcacctg catcctgatg 2777641 ctggccttta cccgcaagag cgatagaaag cgtcataccg cgcgcgcctt cgccttttag 2777701 gatacaagcc ggatatttca ttgtcagctt agaaccgatg ttgccgtcga tccattccat 2777761 tgttgcgttt tcttcacaga ctgtacgctt tgttacaagg ttgtaaacgt tgttcgccca 2777821 gttttggatc gttgtataac ggcagtagcc gccttttttc acgatgatct caacgaccgc 2777881 actgtgaagt gagtttgttg tgtaaacagg cgcagtacag ccttcaacat aatgaacgct 2777941 tgcttcttcg tcaacaatga tcagtgtacg ttcgaactga cccatgttct cagagttgat 2778001 acggaagtaa gcttgtagcg gtgtttcaac cttcacgcct ttaggcacgt agatgaaaga 2778061 accgccggac caaacagctg agttaagcgc cgcaaacttg ttatcagtcg gcgggattac 2778121 ttttgcccag tgctcacgga aaatatcttc attctctttc agcgcgctgt cagtgtcttt 2778181 aaagacgatg ccttgtgctt caagatcttc tttcatgttg tggtatacaa cctcagattc 2778241 gtactgagca gaaacacccg caaggtattt ttgttcagct tcaggaatac cgagcttgtc 2778301 gaatgtttgt ttaatttctt caggaacttc atcccaagaa cgctctgaac gctcagacgg 2778361 ttttacgtag tacgtaattt cgtcaaagtt cagtgagttt aaatctccgc cccattgagg 2778421 catcggcata ttgtagaaat gctcaagtga tttcaagcgg aagtcaagca tccattgagg 2778481 ctcttctttc atgcgagaaa tttcttctac gatttctttt gtcaatccgc gctctgaacg 2778541 gaaaatggaa acgtccttgt cgtgaaaacc atacttgtat tcaccaatat caggcatttt 2778601 tttagccatc cattttcact ccaatccttt taattgccgc cttcttcttt cgcgactcct 2778661 ttttcaagtg ctttccatga cagggttgca catttgatac gggcagggaa ttttgaaacg 2778721 ccttgaaggg cttcaatatc cccgagatct atagaatcat catactcttt cccttgcatc 2778781 atatccgaga aaatcttaga catggaaagg gcagtttcaa tatctttccc tttaatcgcc 2778841 tgagtcatca tcgaagcgga tgccattgaa atggaacagc cttccccttc aaacttcgca 2778901 tcttccacga tgtctccgtc aagcttcatt gtcagtctga tgcggtcgcc gcatgtcgga 2778961 ttgttcatat ccacgacaat gctgtcattt aaaacccctt tatttcgcgg gtttttgtaa 2779021 tgatccataa tcacctgtct gtacaatgta tctaagtttg cattaaaaga catttgtaaa 2779081 atactccttt gtcttttgaa gagcttccac aagcttatca atctcttcct ctgtattata 2779141 cagataaaag cttgctcttg cagtagcagt tacatccagc catttcatca gcggctgcgc 2779201 acaatggtgg ccggctctga ctgcgattcc ctccgcatca agcacagtcg ccacatcgtg 2779261 cggatgaaca tcatcaaggt taaatgtgac aagcccggca cgctcttccg gcccgtaaac 2779321 cgttacgccg tcaagctggc ggaagcgttc aagcgcataa gctgcaagct tgtgctcatg 2779381 gcgggaaatc tcatcaagac cgatttcttc gagaaaatca atggcggcac cgaggccgat 2779441 tgctcctgca ataatcggcg tacccgcttc gaatttccac ggaagctctt tccaagttga 2779501 ttcataaagc ccgacaaagt cgatcatttc accgccgaat tcggcaggct ccatgttttc 2779561 cagcagggct ttctttccgt acagcacacc aacaccggta ggtccgcaca ttttatggga 2779621 agaaagcgca aagaagtcgc aatcgagatc ctgcacgtca attttcatgt gaggcgtgct 2779681 ttgtgcaccg tccaccacaa tgacagcccc attgtcatga gcgattttcg ccatttcttt 2779741 aatcgggttg accgtgccga gaacattaga tacatgagac accgcaacaa tttttgtgtt 2779801 gcttgtgacc gtttctctga cgtcttctaa agaaatcgtt ccgtcttcct gcaacggaat 2779861 atattttaat gtggcgccag ttgcttttac agcctgctgc cacggaatga tattcgcatg 2779921 atgctccatg taggtgatga ccacttcatc accaggtttc aggttggcgc gcgcatagct 2779981 taacgccacc atattcagtg atgtggtcgt gccttttgtg aaaataatct cagccattga 2780041 cttcgcgtta ataaacttgc ggactttttc acgcgctcct tcataaccat ctgtcgctct 2780101 ggttccaagt gtatggacgc cccggtgaac attggaattg tattggttat aatacttatc 2780161 cagtgtttca atgacagcac gcggcttctg ggaagtcgcc gcgctgtcga gataaacgag 2780221 atcatgtccg ttcacttgct gatgaaggat cgggaactgt tcacgaatat ctgtgatatt 2780281 cattacttca ctttcctttc gataacagaa actaattgtt tcttaacgcc ttcaatcgga 2780341 agttcattta ctaccggtgc aaggaatccg taaatgacta agcgttctgc ttcttctttc 2780401 ggaattccgc ggctcatcag gtagtaaagc tgaatagggt ccacacggcc gacagatgcc 2780461 gcatgtcctg cagttacatc gtcttcgtca attaaaagaa tagggtttgc gtctccgcgt 2780521 gctttttcgc taagcatcag cacgcgtgat tcttgctccg cattcgcttt agaagcgcca 2780581 tgttcgattt tgccgattcc gttaaagata gaagaagcgg aatccttcat cacaccgtgc 2780641 ttcaagatat agccttcaga agctttaccg aaatggatga tttgtgttgt gaagttttct 2780701 gtttgctctc ctcttccgac aacaaccgtt ttcgtatcgc cgtatgtgcc gtcaccgtaa 2780761 aggtttgttg tgttttcgga aatcgtgtcg ccatcgttca tcaggccgag agcccactcg 2780821 attttgctgt cgcgtccgcg cgcagcaccg cggcggttca cataagttgt cacaccgctt 2780881 gacagattat ccaccgcacc gtatgtcacg ctggcattat cacctgtgat gacctcactg 2780941 ataatattga agacagcgtc tttcgggttt acagtgctga tgtagttttc tacatatgtt 2781001 acagagctgt ggtcttcagc cacaatcagc acgtggttga atagagctgt atcattgctt 2781061 tcgtggacat aaacagcctg aaccggcgtc tccacctgaa catttttcgg aacataaagg 2781121 aatgctcctc cgttaacaag agccgcgtga agtgcagtta acttatgttc gtcaaccttc 2781181 acgccgtcct tcataaagta tttctccacc aagtcgctgt gctcgcgtgc agcagtcaga 2781241 atatcagtga agatgacgcc tttgtctttc aattcttgag aaagagaaag atgtgccggc 2781301 gtctggtcac gctgtacgta taatgtttta tcttcgtttt caatgtcgat cagcgctttt 2781361 acttcatcag tcaaatcttc taatgaagaa agcggttcgt tatccactgt atgcttcgcg 2781421 aaattcgtga agttccagtt tgtgattttt gttttgtcag gtttcggcat cggcagatcc 2781481 tcagcttgtt caagagcctg taagcgcagg ttcttcagcc aggcaggttc ttggtgcttt 2781541 tcggaaaagc ttttgagata ctcctgatct acggatagtt ttgtacctag tgtcatatta 2781601 atccccctaa cgcttacgct tcttggccaa cagtttcgtc ttcaatgcca agttcttgtt 2781661 tgatccagtc ataaccttct gcttcaagac gctgtgcaag ctctgcaccg ccggatttta 2781721 caacgcggcc ttgcatcata acgtgaacaa catccggagt gatgtagttt aacaggcgct 2781781 gatagtgagt gatcatcagg cagccgaagt tttcgctgcg cattttgttg atcccttttg 2781841 atacaacttt caaagcgtca atatcaaggc ctgagtcaat ttcatcaagg atggcgattt 2781901 tcggttcaat catcattaat tgaaggattt cgttgcgttt tttctccccg cctgagaagc 2781961 cttcgttaag atagcgctga gccatttcag ggtccatttc aaggaactcc atgttttcgt 2782021 ccattttgcg gatgaatttc atgagagaaa tttcatcgcc ttcttctctg cgcgcgttga 2782081 ttgctgagcg aaggaagtcg gcatttgtca caccgctgat ttcacttggg tactgcattg 2782141 caaggaataa gcctgcctgc gcacgctcgt ccacttccat ctccagtaca tctttgccgt 2782201 caagcgtgat gctgcctttt gttacttcat atttaggatg ccccataata gcagctgata 2782261 aagtggattt accagttccg ttcgggccca ttactgcgtg gaattctcca ccttttattt 2782321 caaggtttac accctttaag atctctttcc cttcgatttc aacgtgaaga tctttgatcg 2782381 ttaatgttga agcagccata tctatacctc caaaaatata taatcattat tctcatttta 2782441 ttctcattct aattttataa caaatgaaaa gtaaatacaa ctttttatcg tgccttgcac 2782501 attcctcaag tttaacaaag atcagcactt tattaaagcg attgaaaaag aaaaagagtg 2782561 gattcccacc cttttttaaa agattgattt tctcaataag ctcccgcaga aatccgcttg 2782621 cttttttcat aatcaagctc tctctgccgc tctactttca ttcttgtttc cagccggcgt 2782681 ccatattcct cgtatccaat tccgtgtgac agctgcatcg ctttttccat ttctgacgta 2782741 taatcgaggt tcagtctgtc ctggctgctg caaataatga atcaatccct tcatatattt 2782801 gctttttatt gtaccagtgc tgcgttggat gccgcaaaaa cgatttggcg tgaaatagcg 2782861 gcagatgaga cgaaagcatc ctttcagaac aaatgagaat ggtttttcgg aatattcctt 2782921 ctcttaatgc gtggtgtttc cgaattcctc aatgcactgt tgaacgactg tcacgccttg 2782981 gctgaaagct gcgccgcctc caaatgccgc tgccacactg acggcttcga gaatgttttc 2783041 ttctgacgct ccctgatcaa gacagccttt tgtatgatag atcatgcaat attcgtcctg 2783101 agcattgatg gcaattccga gggcgatcag ctgtttttct ctttcagtca gagaattccc 2783161 ggcaaagcac tgttcagtaa attcgttaaa ttttcttccc atcagcggca tcttttgttc 2783221 aaatgtgcct aaaccatgtt tatattgttt taacgcgtcc tgcatgcttc ctctgtcttg 2783281 attcaaagaa aatccctcca tctgtttaac attccttttt attatgaaca gcttttagga 2783341 aaatacgcga aaaaaacccc ggaattctca tccggggttt cagtcttatt cagatacagg 2783401 aagcacagct ccgtcgtatt ttttctcgat gaagtctttg atctttttag agtgaagaac 2783461 ttccatcagc gctttgattt ttgcagaatc ttcttcgcct tttcttactg cgatgatgtt 2783521 agcgtatggg ttgtttttcg ttgattctac ttcaattgcg tcttttttag gatttaattt 2783581 attttggatc gcatagttta cattgatgaa gaccgcgtct ccttctttgt tttcatatgc 2783641 ttttgccgtt aattcaggcg ctactttttt gaattcaagg tttttcgggt ttttcttaat 2783701 gtctttcaat gttgcgtcaa ctgtttccac tttagaatca agagtgatta atccagcgtt 2783761 ttcaagcatt gcaagcatac ggccttgttc agcaacgttg tttgtcagaa tgattgtcgc 2783821 accgtctgga aggtctttca gtgatttgta tgttttagag taaataccga atggctctaa 2783881 gtgaacagcg ccggcattca caagtttgta atctgtgttt tctttcattt cttgctcaag 2783941 gtaaggaatg tgctggaagt agttcgcgtc cacttcttta tcagctaaag ctttattgta 2784001 cattttgtaa tcactaagca ctttcacttt cagcgtatag cctttttctt tcagcaatgg 2784061 ttcagcttct tttaaaattt ccgcatgcgg tgtttttgtt gccgcaacga caatttcttt 2784121 cttgccggat tcagcgccgt tattcgaacc gcaggcagcc ataactcctg caaatacaag 2784181 cagtaatgca cccaaaaata gctttttcaa tgtaaatcct cccttatcgt ttgtctataa 2784241 tatttgttat tagatcaccg atgatttgaa taataaacac gatgattaaa ataaacacag 2784301 tagcaacgaa ggtaacatca gcgttattag actgatatcc ttctacgtac gcaaggtttc 2784361 caaggcctcc tgaaccaatg gctccggcaa ttgccgttga accgattaaa gcgatggctg 2784421 taaccgtaat gccagaaata agagcaggca ttgattccgg aatcagcact ttgaaaataa 2784481 tcgtagacgt tttcgcgccc attgatttag ctgcttcaat cacaccttta tccacctcac 2784541 gcagcgcgat ttcaacaagg cgcgcgtaaa atggtgccga gccgattacc agcgccggca 2784601 atgcggcgtt tggccctaag atcgtgccga ctaaaaattt cgtaaaacct aatagtaaaa 2784661 taattaaaat aaggaacgga atcgatctga atatgttaac aacggctgca atcactgagt 2784721 tgaccgcttt attctgccag aggcttcctt tgctcgtcag aaagagcagc aagccgagga 2784781 tgaccccgat gacaaaagca aacagtaaag aaatcagcgt catataaagt gtttcatatg 2784841 tcgcgttcca taattcagtt aaatcaacgt tcgggaagta tttttcaaac attcgtgatc 2784901 acctctgctt tcacctgttt gtcattaatg aatcggatca cgttttgcac ttcttcctcg 2784961 tccccgtcaa tgtggatgaa cagtgaaccg taagccccat ccttcgtctg cgaaattttc 2785021 ccttgcagaa tattgacgct gacattgaag tttctgatca tctctgtaat cagaggctgt 2785081 tcagctgact caccgacaaa tgtgagctga accatttttc ctgatgctgt atcatcaaga 2785141 aggtgctgaa gcgtctcttt cgtttcttcc ggctctgtca cctgttgaac aaatcgtttt 2785201 gtcatttgtt cctttggatt tttgaagaca tcgagaacct cgccttcttc gaccaccttg 2785261 ccgttttcca tgacggcgac tctgttgcag attttgcgta tgacatgcat ttcgtgcgta 2785321 atcagcacaa tcgtcaaacc gagtctttca ttaatatcgg acaatagatc cagaattgaa 2785381 tctgtcgttt gcggatctaa tgctgatgtc gcttcgtcac aaagaagaac cttcggattg 2785441 tttgcaagcg ctctggcaat tccgacacgc tgcttctgac cgccgctcag ctgggacgga 2785501 taagattttt cttttccttc taaacctacc agtttaatca gttcattggc gcgcttgatc 2785561 cgctcgctct ttttcacccc ggcaatttct aaaggaaaca tgatattatc tctgacagtc 2785621 cgcgaccaaa gcaaattgaa atgctggaaa atcatactga tctcatggcg tgcttttctt 2785681 aaaccgcgtc catttacttc attaatcttg gttcccgcca cttccacggt tcctgaggtt 2785741 ggtttctcaa ggccgttcag cagacggatt aaggaactct taccagctcc gctatatcct 2785801 ataattccaa aaatctcacc ttttttaatg gaaagcgaga cgttttggac agcattgaca 2785861 tctccatgtt tcgacttgta aacttttgaa acatcctgaa gattgatcaa agcaatcacc 2785921 tgccttaaca ctattctaag aaatcttccg gttttttctg caaaagaaaa gcctttctgc 2785981 acacttgagc agaaaggctt atataaaatg cctttctctc atctttcaaa gctgaacgct 2786041 tcgtgtgaat tggcaccatt tcaacagtgt tgatggttgc cgggcttcat agggcacttc 2786101 cctccacctc tcttgataag agaaatatat agtctttttc gtccggaaat tcttaatgta 2786161 gaatagcacg gcgaatgatt aaatgtcaat aaaataaatg atgtcaactt ttactattat 2786221 aataatttat tattttttaa ttttttaaaa tcctctgaaa aaatccattt gtcagccaga 2786281 gaatggcttc cagctttaac agggccctga atgacccctt tactttgagg cttccgctct 2786341 gaataaggtg ctgaagggaa atgtctccgt gcaataaatc aataatttcc gtttggtttc 2786401 cgtaaaaggt caggttggac gtttggggcg gagaaacttt tttcatttct ccctgttcgt 2786461 ttattgagac ggttaaggct tctgcttctc cttggaaggt aatgagcaat gttgaggcat 2786521 tcaaaagggg ttttaaaaac agatgctgat actcatcttc taaaacttcc gctttctcca 2786581 tatgtacaac ctcctatttg ttggtcatac atacacattt ctctctttgt cgcaagaacc 2786641 cctttataaa acgaacgaca atttcattgg atatgctgag aaatatgtca taaatgggat 2786701 gcggaagatg atttttgttt gatcagctca tataaataag aaacggaatg aaatgcatat 2786761 cctctttcga ccatctttcc gcctttaaac agcagaaaac aagggacgct ttcaatttga 2786821 tacgcttttg cgaatgtcgg agagtaattg acattgtttt gatagaaggc gacatccggc 2786881 agcatttctt tcaccactgt cagcattttg cttgcaagct ggcaggtgcc gcaaaacgga 2786941 gtatataaat atagaaggta cacatcatct tcaatgtgat caagttcgtg ttcttggagt 2787001 tctttcatgc tatacacctc gggactttct ttcaagaaaa atagtatgga cattcagatt 2787061 cgcacgcagc aatacagaag cgatatggtg cctgggcgca gccgctactt ccttataggc 2787121 tctgtcgaca tggagatggc aggcttcatt aaattcacgc ttcagctgtt ttctcaattt 2787181 ctcacctgat tcatcagcat caactaatat atagacgtct ttatcataaa gctcgtcagc 2787241 caattcctcg agcctcagct ggctgattgt tccgtttgtg cagataatgc gcatcggttc 2787301 attcaggacg ctttcgattt tctctttatc tgatttcccc tcgacaatca taaccttttc 2787361 cagctcatcc atcttcatct tgttcacctg ccgcgtcaaa tttgaaatgt tcagattgta 2787421 aaagaaggca gtgaaattca ccgccaacat taacaccagc cgttttcgta gtcacaatct 2787481 acatattttg cgtcgtctcc agagaccaca tcggctgtct tataaaattt ctcattttca 2787541 aaggaataac cggacttaag ctcatattca ttcatgcttg tcatttggcc gatcatctca 2787601 ttatcatgat ataacgagag ccggccattt tgaaagcggc ctgtcacgtc attggtgaca 2787661 tcgagctttt gtttgtcgaa agccatattg gacacctccc ataacgttag cgtgtccaat 2787721 tgcttttacg gctatcctgt tttagtcttc ttgtgtcatc tcttcgtatt gctctgctgt 2787781 catcagtttt tcaatttcag aagcgtcaga tggctcaacg acgatcatcc atgctttttc 2787841 gtacggagat tcgttgacga attccggact gtcatcaaga tcttcgttta cttccacaac 2787901 cgttccgtta atcggtgcat aaagctcaga taccgtttta acggattcaa cactgccgaa 2787961 tggctcgtcc gctttgattt cagcgcccac ttcaggaagt tcgacaaaca cgatgtcgcc 2788021 tagttcggac tgggcaaaat gcgtaattcc gattctggct ttttctcctt caacttttac 2788081 ccactcgtgt tctcctgagt aacgcaaatc ttttggtatg ctcaattgaa tccctccatt 2788141 ttttacagca ctacaataag aagataccac acttttcaaa aaaaatttac attaagccca 2788201 gttttcttca aattggtctt ctttaaatcc gacagtcact ttttcgccgt ctgttgtaag 2788261 cgggcgttta attagcatac catctgaagc cagcagttcg agctgttcgt cctctgacat 2788321 atgatacagc ttttccttga gattgagctc gcggtatttc atgccgctcg tgttgaaaaa 2788381 tttcttgaga tccagcccgc ttttttcata aagcgctttt aattcttctt tgcttggcgg 2788441 ctgctcagca atatgtattt cgtttatttc tttcccatgc tcttcaagcc acttctttgc 2788501 tttgcggcac gttccgcatt tagggtacca gtaaaaagtt aacgacatct tcttccccct 2788561 caataaaata atcgaggtta ttttaacaca gtttgtttta aaaacctaaa acagtgcttc 2788621 ttaaaaaaga gctccgcgca tgcggagctc atggccaatc agacagtata tttctcagcc 2788681 tcaaaaatgc ctgccgccgc ctcgcgtttt ttctgaatca cgtttttagg cgttacgcgt 2788741 gtcagcttgc gcagagcgga aagcatcatg cggagtgaat ctccttcttc cattgcgata 2788801 agggattcct ttgcatgcgc ttcgatttcg ttaaaggcct cttgaacgaa aatttctgtg 2788861 tacagcacct tttgcgctgc tttttcagcg ccttgtgcgg caatggcctt ttccgttctg 2788921 agcacggctg attccattgc gtatacattg ctgacgatat ccgctacgtt cacgagaatt 2788981 tcttgctcac gatcgatcgc ttttccgtat ttttgcgcgg ctaggccggc agcaaacaac 2789041 gcaatttttt tggcttgctt gacgatatat ttctcctgct ctaagacgcc gcttccaggc 2789101 tcttcaggca taagcatcat gagttcttcc tgcagcgact gcgctttttc gaataaaggc 2789161 agctcgcctt taagcgcttt tttcaggaag gtgcttggca cgattaaccg gttgatttcg 2789221 tttgtgcctt caaaaatccg attgatcctt gaatccctat aggccctttc tacttcgtat 2789281 tcctgcataa agccgtagcc tccatgaatc tgcacgcctt catcaacgat ataatcaagc 2789341 gtttcagagc cgaatacctt attcagagag cattcgatgg cgtattccgc aatcgatttg 2789401 gcgatttgcc ggccgtcctt gagatcttcg gccgtgaact ggctcatatt gtcttcaaac 2789461 agcccgacgg ttctgtatac agagctttcc atcgcataca gccttgaggc cattgtcccg 2789521 attttttcct gtgtcaatga aaaaccagca atcggcgttt taaattggcg gcgctgattt 2789581 gcgtatgccg cagacagctc gatgacgcgt ttagatgcgc cgattgtgcc aaccgccagt 2789641 ttgtaacggc cgatgtttaa aatattaaag gcgatgacat gccctttgcc gatttctccg 2789701 agcaggtttt cctttggcac ttcagcttga tccagaatga gggttcttgt cgatgatccc 2789761 ttgattccca ttttcttttc ttccggtccc gtggagacac ccgggaactc tttttctaca 2789821 ataaaggctg aaaacttgtc gccgtctacc ttagcgtaaa ctacaaatac atcggcaaaa 2789881 gcagagttgg taatccactg tttttcccct gttaatacat aatgggttcc tgcttcattc 2789941 agcacagctg ttgtttttgc tccaagtgca tcagacccag agccaggctc agtcagagca 2790001 taagcggcga tcttttcgcc tgaagcgagt ccaggcaaat attttttctt ttgttcttct 2790061 gacccgaaaa agacgatcgg caaggaaccg ataccgacat gcgcgccata agaaagagaa 2790121 aagcttcccg cacgcgaaaa tttctcagtg atgagtgccg agctgatttt atcaaggccg 2790181 agcccgccgt attcttccgg cacatcggcg ccaagcagcc ctagttcgcc cgctttcttc 2790241 aacagtctga cagaatgctc gaattgatgg ttttcgatat catctatatg agggagaaca 2790301 tcttgctcga tgtaatcctc tgttgttttc gcaatcattt tatgctcgtc agtgaaatcc 2790361 tccggtgtat acatttgatc gtatgtgaca tcctcgatta aaaatccgcc gcctttttgt 2790421 acgtcagccg ctttttttgc catttgtttt tcccccttta gcataattca aatacaccgg 2790481 ccgctcccat tccgccgccg atacacatgg tcacgactcc aaattgctcg tttctccgtt 2790541 tcatttcatg gatgagtgag agtgtaagct ttgtgcccgt acagccaagc gggtgtccaa 2790601 gcgcgattgc gcccccgttg acattcactt tttcttcatc aattcccaat tccctgatta 2790661 cttgaatggc ctgtgaggca aaagcttcat tcagttcaaa caagccgatg tcctgcagct 2790721 gaagtccggc aagcttcaaa gcgcgcggaa tcgcttccac cggtccgatt cccatcactt 2790781 ccggcggcac gccgcctacc gcaaaggagc ggaatttcac aagcggcgcc aggccaagag 2790841 catcggcttt ttcccggtcc atcagcatga cagccgccgc tccgtcactc gtttgtgagg 2790901 aattgcccgc agtcaccgtc ccgtcaacgg aaaaggccgg gcgcaatgtc gataagatgt 2790961 ctgcagtcgt ttgcgggcga acaccttcat cctgagaaaa cacaaactgt ttttccatag 2791021 gcttatggtc ttctccgatt tctgtcaccg tcacttcgac gggtacaatt tcatctttaa 2791081 attttccttc tgcaagggct ttagcggcgt tttgatggct gcgaacggca aacgcgtctt 2791141 gatcctcacg ggagacgccg tattttttcg cgacttgctc ggctgtgtgc cccatgctca 2791201 tataatattc cggtgccttt tctgccaaag caaggttcgg acgggtaaca tgccccatca 2791261 tcggaacttg cgacatggat tctgctccgc cggcgatcgc tgtatcgtag gcgcccagca 2791321 taattttttc tgctgcatac gcaatagact gaaggcctga agagcaatag cggttaactg 2791381 taatcgccgg aaccgtgtac ggcaggcccg cgagcgcacc gatatttctc gccatattaa 2791441 gcccctgctc cgcttcaggt gttgcacagc cgataatcaa gtcatcaata ttgccttcgt 2791501 agccgcctgc ccgtttcagc gtttctttta cacaaatcgc tcccaaatca tccgggcgaa 2791561 cggtggccaa cgatcctttt tttgcttttc caaccggtgt tcttgcacct gacacaatga 2791621 ctgcctcttt cataagctcc ctcctaattc cgtaaaggtt tacctttcac aagcatatgc 2791681 tgcattctcg cttgagattt tgcctctcct gacaaactca aaaacgcttc tctttcgatc 2791741 tccaataaat actcttcatc aacctctgta ccaaacggca cttttccgcc cgcaatgaca 2791801 taagcgagtt ttttcgcgat cttaaaatca tgctcagata tatagccgga cagcttcatc 2791861 tgctcagcgc caagcaagag tgccgcataa ccggtttctc ccggcacctt gaccttttct 2791921 tttacaggcg gccgccagcc ggtatcgtat aaagatgcgg ccagctgctt cgcatcgtat 2791981 aacaggtggt cttgattcac gctgatctga tccgtttctt ttaagatgtt catctcacga 2792041 gcctcttgag cggaagcgga cactttcgcc atcgcgattg tttcaaatgt tttcattgcc 2792101 gcattcatcg gatcatggcc gcggcgaaga tggttgatgt acagctcttt gttacctcct 2792161 ccgccaggga tgaggccgac accggattcc acaagtccca tataggcttc gcttgccgct 2792221 tgaatgcgcg ccgccggcag gcatgcttcc gttcctccgc cgagcgtcat gccaaatggc 2792281 gcggcgacga ccggtttcgc actgtatttg atcttcatca tcgtctcctg aaaacggcgg 2792341 atcacaaaat caacttccaa aaagttgtca tcttggactt ccattaagat catggcgaga 2792401 ttcgcgccga cgcagaaatt tttcccttga ttgccgatga caagcccctt gtaattccgt 2792461 tctgtttcct ctaatccttt gtggatcatt tgaatgatat cgaggccgat cgcattgctt 2792521 ttcgaatgaa attcaagaag ggccacatca tctccaaggt caattaagct tgctccgctg 2792581 tttttcgcaa tcacgccttt tgtttcttta agtgcttgta aatgaattcg ttttttgttt 2792641 tctttcacgg ctctgtattc gccgcggtca taataaaata ccgttccgtt ctctttgatg 2792701 tagaaggttt catttccttt gtccagcatc tcttttatcc agccaggcat atctgctcca 2792761 agctgctcaa gcttttccgc tgactgcttg aggccgatgg cgtcccacat ctcaaaaggt 2792821 cccagttccc agccgaatcc ccacttcatg gcttggtcaa tcgcatgaat atcatcggca 2792881 atctcgccaa gcagctcggc tgagtaaagc agggtttgag aagtgatatt ccacagcaaa 2792941 cggccggccc tgtcatccga ataaataagc gctttcattt tggcttttgt cccttttgcc 2793001 tgttttgccg cttcaagtgc cggtgatttc atttttgtcc gctcgccgta agtaagcgtc 2793061 actgggtcaa gctcataaat cgtttttcct tcttttttat aaaagccttg gccggccttg 2793121 cttccgatcc accctttttc cagcatatcg ttcatgaagc ttggaatgcg aaacacttct 2793181 ttttcatcgc catcagcttt gtcatacaca tttcgggcaa cgtgggcgaa tgtatcgagg 2793241 ccgaccacat caagcgttct aaaggtggcg cttttcggcc tgccgatcag cggtcctgtg 2793301 atcgaatcaa cctccccgac ctgataaccg cctttcagca tttcttggac tgtcacgaga 2793361 agcccgtaag tcccgatgcg gtttgcgata aagttcggtg tgtcctttgc tgtaacaacg 2793421 cctttcccga ggacattttc tccgaaagct gtcataaact ttaaaatatc aggatccgtt 2793481 tccttaatcg gaatgatctc tagcagcttt aaatatcgtg cgggattaaa aaaatgcgtt 2793541 ccaagaaaat gggctttaaa atcatccgac cggccttcag ccatttcctg cactgatatg 2793601 ccggatgtgt tgcttgagac gatgcttcca gtctttcgat gttcatccac aagagcgaaa 2793661 attttctttt tgacttcaag gttttcgaca acgacctcaa taatccaatc tgcttctttc 2793721 agtttttctg catcatcctc cagattgcca ggtgtaatat aggaggtatt tttcgctgat 2793781 gtgaggggag cgggcttttg tttcagcagt tttttcatcg cctgccggct cagcctgctg 2793841 cgcacctccg aactgtcctt cgtcagcccc tttttttcct cttcctttgt caaatcgttc 2793901 ggcacaatat ctagcagcag gacaggaatt ccgatgttag ccaaatgcgc cgctatcccg 2793961 gaacccatta cccccgatcc taaaacggct gccttccgaa tgtgtttgtg catgagatat 2794021 cccccttgaa cattgaatga atagtcattc attttttgac taaaaaaaat gaaacccgtt 2794081 tcttctttca tcttaaaaga tttccggttc gacttcaata gctaatttgt tatttttttg 2794141 tatgaagcct ataaaagtcg ggcaacttaa gcccggaggt gaagggaatg gtacgagaga 2794201 aaaaaaatcc gtcttcagcg gcagtcagcg cggcgagcgt aaagggagat gccggtccga 2794261 ctcagcatta cggcggcgga aaacggacaa gtcaaaatca gcagtataaa aaacataaca 2794321 tgggacaatc ataatgcagc tgcttcccac ggctgctttc actttttcaa aattcctttt 2794381 aacacaaacg ctgcattggc aggccgttcg gcaattcttc tcataaagta gctgaaccag 2794441 tccgttccat atgggacata cacacgcatt ctgtagcctt ccttggcgag ttccttctga 2794501 cgctccggcc tgatgccgta tagcatttga aactcaaatt gcgatgcggg gatttgatgt 2794561 tcggcgacga gctgtttcgt aaatgcaatg atgtcatcgt catgtgtggc gacagccgtg 2794621 tagttcccgc ttaacaactg cagctttatt aagctctgaa aatgaaggtc cgtgcctctt 2794681 ttgtcgggaa acgctacagc cgcagattct ttataagcgc cttttacaag tctgagattc 2794741 ggctttaagt cccgcatctt tctgatatct tctgccgccc ggtacaaata cgcctgaatg 2794801 accgtgccga gcttctcaaa ttcctgtttg cattgcctgt aaatagaaag tgtctgttca 2794861 taatgagaat agtcttccat atcaatggtc acagcaacat catattgctt cgcaacggaa 2794921 agaatggcgc gcaaatgagt aagagcaagt tcttctgaaa gatcgagccc gattgaggtc 2794981 agcttaagtg aaagctctga attcaattga tgttcggcaa tggcttgaat ggctttcttg 2795041 cattcctctg cgacttggtt tgcttctttt tccgaagctg catactcgcc taaataatca 2795101 attgttgcac acaaaccgga tctgtttagc cttttgacgg tcttaaccgc cgattcaatc 2795161 gtatcccctg cgacaaacct tcgtgctcca agccgcgttc cgtatgcttt tgcgaacttg 2795221 gtaagtgttt tattttgaga taagaataaa aacacatgtc tcaacatccg actccctccc 2795281 gccgtcatct tcaaaacacc tgtatataac tcccagtctg aaggaaacta taaaatgaac 2795341 agaaaccaaa ggaggatcac aatggataat cagcagcaat ctcaaatgcc gccttccgtt 2795401 atttcgacaa aggatcattt gtatctcaat gacatgctga actggaattt gctcgcgatg 2795461 aaaaaagcgc atttcatggc gcagcagtgc caggatcaaa cgttaaagca agaactcgac 2795521 cgcgtcggac acatgcatca tgatcactat caaagaatat taaagcacct gcagccaggc 2795581 cagcagcagt ccggctacat ccaataagga ggcgccagaa tgaatcagca aaatcaaaaa 2795641 atcagcaacc cgcagacacc tgtaccgaca acatcggaaa tgaatgacag agatttcgtc 2795701 aacgaattgc tgacaaccga aaaatacatg acaacagctt attgcactgc cttgcacgaa 2795761 ttcagccacg agtctcttta tcaggatatt caatccattt ttgatgagtc acaaaaagcg 2795821 caaagaaaac tatatgatct catgttccaa tatggatggt attctgttga agcggaggat 2795881 tcacaaaagc tgcagcagtc ctatcaaaaa ttccagcaga ccattcagca gcagtctcct 2795941 tatcagcaat aacaacatta gtaaaaagga tacgatgttc tttcgggcat ctatcctttt 2796001 tttgtgtaaa atcagttgac ttttcattta cgcttattta tatttaataa gcattaacta 2796061 ttttgtcatt aaaatatata tacagtgtat gtaacagagg ggaaatgaat atgaagagtg 2796121 cggatcagtt aatgtccgat attcaattat cgcttcaggc gctctttcaa aagatacagc 2796181 ctgaaatgct ggaaagcatg gagaaacaag gtgtcacccc agcgcagctg tttgtgctgg 2796241 ccagcctaaa gaaacacggc agcctcaaag tttctgaaat tgccgagcgt atggaggtga 2796301 agccaagcgc ggtgacgctg atggcagatc gccttgaaca aaaaaatctt atcgccagaa 2796361 cacacaacac aaaagacagg cgagtgattg atctcagtct tactgacgaa ggagacataa 2796421 agttcgagga ggttttggcg ggcagaaaag ccataatggc gcgctatctt tcctttttga 2796481 cggaggagga aatgctgcag gcggcgcata ttacagcaaa actcgcacaa gcagcagaaa 2796541 cggatgaaaa gcaaaacatg aaaagaggaa acggatgaaa atgagtaaag aaggcaaaca 2796601 atcaaaacga acgttattaa taacaggctt aattattgcc atgttttttt cagcccttga 2796661 cggtaccatt gtcggaacgg ccatgccgaa aattgtcggt gatctgggcg gtttgagcat 2796721 gatgacctgg ctgacaactg catatttgtt aacatcaaca accattgttc caattgccgg 2796781 taaactggct gatttattgg gacgccgcat tgtctatgta tcaggtttga ttatttttat 2796841 ggccgcttct gctttgtgcg gaatggccaa caacatgacg gaattgatta tcttccgtgg 2796901 actgcagggc atcggcggag gcatcatgat gccgatggcg atgattgtca tcggtgactt 2796961 gttcacagga aaacagcgtg ctaaattcca aggtgtcttt ggcgcaattt acgggctggc 2797021 ttcagtgatt gggccgcaaa tcggcggctg gattgtagac tcgttaaact ggaaatgggt 2797081 tttctatatt aacctgccag tcggaattat tgcggttatt tttattgcca ggggattaca 2797141 gggacgccag cagactggtc cgatcaactt cgatatcgct ggtattttca caatgattgt 2797201 cggtgtggtc agcctcctgc tcgccttaag ctttggcgga aaagattatg catgggattc 2797261 atggcagatt cttgggttgt tcgctctcgc actgatcggc attgtcagct ttatcatcgt 2797321 agaatcaaaa gcaaaagagc caatcctgcc aatgtattta tttaaaaaca gaacatttac 2797381 atttctaaac ttgatcggct tctttatgag tatcggtatg tttggcgcca ttacgtttgt 2797441 tcctttcttt atgcagggaa ttgtcggtgt aagtgcgtct gaatcgggta caattatgac 2797501 accgatgatg atttctatga ttatcacaag tatcatcggc ggacagcttg tttataaaat 2797561 tgggattaaa ccgcaaatca ttacaggcat gctggttatg gccggcggat tcctgctgtt 2797621 aacgacattg gatctcgaca cgagcaagct tgtcgctaca tcttttatgg cgattattgg 2797681 tctgggaatg ggtcttgtta tgccgattct gacattggct ttacaggaaa gcttttcgaa 2797741 ggaggagctt ggagttgtca cttcatccag ccaattcttc cgttctatcg gcggaacatt 2797801 cggcattacc atgctgggag ccgtaatgaa tgcgagatca ggaaatctat taacagataa 2797861 attggttcca tatttagact ctcttccggc acaggcaagc tcgtttgccg cccagctaaa 2797921 gggtatgatt gatacaaatc cgcaagggct gctgcaatca ctgttcagtc cggacgcggt 2797981 caaacaaatc cctgcggctt tctcatccca tattgtgccg attttaaaaa catcgttgat 2798041 ggattcgctc cacagcgtgt tttatacggg cctgatcttt atcgcagtcg gagccgtatt 2798101 caccttgttc ttaaaaccta tcaagctatc aaataagaaa gcggaagacc aacaagaaaa 2798161 agagaaggcg gcaaaagccg ttgaatcacc ttcccattaa tagagcaccc cgcgggtatc 2798221 aatccgcggg gttttttatt caatcatctg ggctcttcca tttccgaaag accaatcctc 2798281 atcctgattt ccggccagca tgataaacac atcttctttt cttacaccaa gctcggaatg 2798341 aatccggctc gcgattgagc ggtaaagtgc ttttttctgt tcagttgttc ttgactgttt 2798401 cagtgtaaaa tgaatgtata tcagttcatc agtacgctcg acttggagat aaaatggatc 2798461 ataaaaaaat tcgctttttt catattgtct gatgacttgg aaatagtcat cttccggcac 2798521 attgatttct tcaatcatcg attggtggat agtcctgctc agtttttgaa gccacacttc 2798581 gcttcttccc gaccgtaaat gaatctgtac aaatggcatc tccccgcatc cctttcttta 2798641 cagcgtctgt ccgctgtcaa ttgtgataat ttggcctgtg agtgattcct gttcaattag 2798701 tgaacaaatc aatttggcaa catcatctgg ttcagcaata cactgcagca gcaaagagcc 2798761 gatcatgctt ttcatttttt cttcccgtcc ggcccaccat ctcgttgcca cagctcctgg 2798821 tgctacaccg ctcactctga tttcaggcgc taaggcgtgg gccaatgatt tcgttaaacc 2798881 gtgcaccgct gattttgata ctgcgtaagg cattgatgag ccggcaccag ttatccctgc 2798941 gatgctgccg acgtttacga tcgccccgtc cttgcttttc ttcatgaacg gaaccactgc 2799001 ccgcgcgcag aaaaacatcc ctttcacatt gacggcatac agctcatcct agacgtcttc 2799061 tgtcgcagcc tcaagatcat ccattggaat atgccgtgta atgctggcat tgttgactaa 2799121 aatatcaacc gtgccgtgtg tgttcacgat tgcttgaatc atatcctgca cgtcgctgtt 2799181 tttggataca tctgcttgga tggcgaaggc ttgcccgcca gctttttgaa tcatttccac 2799241 tgtttcctcc gcttctgatt gcgagcgtga ataattcacc gccacaatcg ccccacgctt 2799301 tgccaattcc atactggctg cttttccgat tcctgtgccg ccccccgtta cgagagctat 2799361 tttgttcaag acattcattg ccgccactcc ttgctgttga ctaaagtata tttctgattc 2799421 cattgtaatc cagctttgat gttacgtata atgattgtta aagatactag atatcactca 2799481 gattgatagt aaacgaacgg aggagttcaa aatggaaagc ggagatttac gtgtgtttca 2799541 aatggtagct cgtgaaggga ccattacgaa agcagccctg cagcttggct atgtacaatc 2799601 gaatgtcacg gccagaattc aacaattgga agctgagctg ggtaccacac tgtttttgcg 2799661 ccataatcgg ggcatgacac tttctgcaag cggaaaattg ctgctggact acgcaaataa 2799721 aattataggc cttcttgatg aagcgtctaa agcgctctca tcctccgcag aaccaagcgg 2799781 gccgcttatg atcggctgca ctcagacaac cgccgcggta aggcttccaa agcttctggc 2799841 atcttattat gaagaacatc caaacgtcca gctgtcttta acaacaggac atacgcaatt 2799901 tctccttgat aaagttcttc gttatgaatt ggatggcgcg tttatcggat gcgaatgcca 2799961 tcatcctgag ctcgaatcct atcctgcgtt tgaggaagaa ccagtagttg tttcggctgc 2800021 ctccgtgccc gatgttgagg aagccatcac aaagccgatt ctcgtttaca gcacaggctg 2800081 ttcgtatcga gaaacacttg aaaaatggct gcgttccgtc ggtgtcacac agccggtcat 2800141 tatggaattt gggacgcttg aagcaattat cggcggggtt acagcaggtc ttggcatctc 2800201 gttgctgcca agaacggttg tgcagaaaca tgaagcagaa ggatcaattc gattgtaccc 2800261 gctgcctgaa gctctcagcc agatgaaaac agagtttatt gttcgaaaag attcgtttat 2800321 cagcagcgcg ctgagaacct ttatggattc ctttacgcca gttaaaacgg ctgaatcaca 2800381 aaaaagcagt ctgctataat gaacagactg ctttttggct attgtttgtt tcgatgcgct 2800441 tcatttaatt ccttaatatg ctgaatgatc tctttaatgc cctgcttcgc gtcggggtat 2800501 gtcgcattcc aatgcttagc gagcggaggc atgcttttgg ctatatgggt gtacaaaatc 2800561 cattgcttca cttcttcttt tagctcatcg tttgtttcac caagcagaag ctcagtatac 2800621 ttctccagca atccatcaag ctgctcctga agtttttgtt ccattttcca tcttcctttc 2800681 gaaaaaacag caaggagctt tctcaattga aagctccttc gctgcgttat ttatccatgt 2800741 gatgtgaaag ccgcttcctg gacaatgcat ctgcccctgc catgaggaat gcaaagaggc 2800801 gttccgaaga gcgggtcctg tgtaacctga cagttcatag aaaacacatt ttgcacaaga 2800861 tcacaagtga tgacctcttc cggacggcct tctgcataaa tccgtttatc ttttatggcc 2800921 acaagatgat gcgcatagcg gcacgccaag tttaagtcat ggagaaccat aacaatcgtc 2800981 cggtcttcct tttcattcag ctcaaacagc aaatcaagaa tttcaatttg atgcgtcatg 2801041 tctaaatacg tcgtcggctc gtcaagaagg atgatatccg tttcctgggc aagcgtcatc 2801101 gcgatccaag cccgctggcg ctgtccgcct gacaaagaat caacggcacg gtcagccatg 2801161 tcctcaagct ttgttgcttt aagcgctctt tcaactgctt cctcatcctc ttttgaccac 2801221 tgcttcagcc agttttggta aggatatctt ccttgcttca ccagctgatg caccgtcagc 2801281 ccctctggag ccgaaggacc ttggggcagg attgcgagct cttttgcgac ttccttcgtc 2801341 ggaagcttgg caatcgctct tccttccagc agcactgaac cgcctctcgg cttcatcagg 2801401 cgcgctaatg aacgtaaaag tgtcgatttt ccgcagccat tgctgccaat aaatacggta 2801461 atttcacctt tgggaattgt taaattcaac tcatcaataa taacggcatc cccgtatcct 2801521 aagctcagcg tttctgtaga aattgcactc atacccataa ccgctccttt ttgctggctt 2801581 tttagcagca ctatgtattg cacgttttct atatacatgc ttttaagtca attgtcatca 2801641 atgcaaatga ttccgatatt cagccatttg atatggtcat atatccctca ttgtagcaga 2801701 aaacactgac tttgaaaatc attttcaatt agttttatgg acataattga cgtttatggg 2801761 ttttttatca caagattact tcttgatttc tctgatggag ccgtccttca gcttcaattt 2801821 taaatcgata tgatcataat gactgtccag attaaatgct gccagcacac tgtgtatcac 2801881 ttctgtttca gccatttggt ctgtcacgga aagctcgctc aaaatcattt tcatctcatc 2801941 taacgcttct tctccttcct gattgacacc ggagagctta tcctgtattt ccgctttttc 2802001 ctgagtcccg ttctttgtat agattccttc ataacggtta tgctcaccat ccccgtagct 2802061 cacacgaagc gaaaaattac tgtagggaac ggacttcagc tgggtgacgg ctgtattttc 2802121 tccttctgcc tgatgctggt cttcattgaa acggcagccc gcaatcagaa ccactgcgag 2802181 acatacagcc ccggctgctc tgatcaaatg catatgtttc ccccctgtag gattccattt 2802241 attttaggta tatccagaga atgaaatcct cattcagaga agaattgaaa aagccggggc 2802301 atttaacgcc acggcttttt ctttaagatt cggtcatttg taaaaaggtt tcggcgtcac 2802361 gcacagccag cttgatggca ttctcccaga aatcgcgctt tgtgatgtca gcgcccaaat 2802421 gcttcatcgc caaatcctcc actgtcatag aagccgtatc gcgcaatagc gccatatact 2802481 tctcttcgaa tgtgtctttt tcttcaagcg ccaacgcgta aataccaaga gaaaacaggt 2802541 agccgaatgt ataagggaaa ttgtaaaacg gcaccctcgt gatgtgaaaa tgaagctttg 2802601 atgcccaaaa aagcggatga tattcttcta acgcattgca gtatgcctct ctttgcgcct 2802661 cttccatcag ctcattcaag cggctggccg gtaccactcc ccgctttcgt tcctcgtaga 2802721 atctcgtttc aaatagaaat cttgcgtgaa tgttcatgaa gaacgcaacg cttctttgca 2802781 ctttatcctc cagaagaaca agcttttctt ccctcgtctc ggcctgctgg acagtcgcgt 2802841 ccgccactat catctctgca aacgttgaag ctgtttctgc aacgttcatg gcgtaggaac 2802901 ggtttaacgg cctgacgttg agcattgctt cctgatggaa cgcgtgcccg agttcatgcg 2802961 caagggtaga gacatttgag gcgcttcccg aaaatgtcat gaaaatccgg gattccccgc 2803021 tgtccggaaa actggtgcaa aagccgccga ctctttttcc gctcctgtct tccgcctcaa 2803081 tccagccgtc ccgaaacgct ttttcagtga atgaggacag ctttttgcca aacgttgaaa 2803141 actggctggt aatgatattt gcggcttcat catacgaata gacctttccg tcagaaccga 2803201 tcggtgcctc gacatcgtac cagctgagtt tttcaaggcc gagcatggat gctttccggt 2803261 tcaaaaactg aacgaacggc ttcttgtttt cagtgatgac ctgccacatc gtatcaagtg 2803321 tttctttttt catcctgtta atttgcagcg gttccttcag gacattctcc cagccgcgcg 2803381 ctttataggt ttcaagccgg aatcccgcca aatgattcag cgtgctgctg aaaatatctt 2803441 gcttgctctc ccaagcttgg cggaaacgtt catatactgt ttttctgaca gtacggtctt 2803501 gatgatccat catattctcc gcctgaccga cagacaattg cttgttttca ccgttttcct 2803561 catacgggat cgtcattttc ccgacaacca tattgtataa gtcactccaa gcgtgatatc 2803621 cgtccaccgc aaggtttccg atcagttttt ccttaccggg gctaagcttt tcggcaaccc 2803681 tctgtcttct ttcatttaat atgtaagaaa catcgcgcaa tcccggtttt gttaacaatt 2803741 cattccacac gtcttgatta atgtccacaa gtttatgatc taatgtaacg agcgacgatt 2803801 gaaaatctgc ggaaagccga ttcatgaggc ctgatgctct atagcctttt gatcattgat 2803861 attctgggcc tggaggcaag caacaaaagc gccggcctgc tgaagcttga cggatgtctg 2803921 ttcgaataaa tcaagcaacg cggtcagccc ttcagcctct tcaggcgatt caggcacctg 2803981 aaacgcatca gtcctgtctt gaaatgcacg cagactttgt gacagcttct caatataacc 2804041 tttgaattct tccgattggc tcccgccctt aaaaaatgaa tcaagatccc atctttggcc 2804101 taccccttgc agcgccatat cacaaaaccc ctttccttct ttcgttctat tatagaacaa 2804161 ttctgaatta ttgtataaaa atttctatta caggcgtcat ttcgtgttca ggatagtaca 2804221 atagctgtag cagtttaata ggagggttag gatgaataaa aaaatagcca tcgtgacagg 2804281 agcgtccagc ggcttcggtc tgctggcagc tgtaaagctt gcccgatcat ttttcgtgat 2804341 agccacatca agacagcctg aaaaagcgga acagcttcga gaattggctg cagcacacaa 2804401 tgtgtctgat tctattcaca ttacagctct cgatgtcacc gatgaacaat ctatagtctc 2804461 attcggaaaa gctgttagtg cttacgcccc gatcgattta ctcgttaaca acgccggaac 2804521 ggcttatgga ggatttatcg aggatgtgcc gatggaacat ttcagacaac aatttgaaac 2804581 gaatgtcttc ggtgtgatcc atgtgacaaa aaccgtgctg ccttacataa gaaagcatgg 2804641 cggcgcaaag attataaacg tgagcagcat cagcggactg acaggattcc cagcgctgtc 2804701 gccatatgtt tcttccaagc atgcattgga aggtttttct gaaagcctgc gtatcgagct 2804761 gcttccgttc ggtatcgaaa ccgctttgat cgagccgggc tcatacaaga catcgatctg 2804821 gtcaacgtca ttatcaaatt ttatgtcggt gcctgctgac gattcagcct atcatcaata 2804881 ctataaaaag atcctttcct atgttcaaaa aaacggagaa gaaagcggag atccccaaga 2804941 ggttgccgac ctcatttatc aattggcaac aaaacagcac ataaagaatt tgcgataccc 2805001 gatcggaaag ggcatcaagc tcaccctgct gttccgatcg ctttttcctt ggtctgcgtg 2805061 ggagtctatc ctgaagaaaa agctattcag ctgatctaaa ttataattat tataatttag 2805121 tattgatttt tatttagtat atgatataat taagtcaaca gatcacaagg aggacgttat 2805181 cttatgaaaa ctgaaaacgc aaaaacaaat caaacattag ttgagaattc actgaacaca 2805241 caattatcaa actggtttct tttatactct aagctccacc gtttccattg gtatgtgaaa 2805301 gggcctcatt tctttacatt gcacgagaaa tttgaagaac tttatgacca tgcggctgaa 2805361 acagtggata ccatcgctga gcgcctgctg gcgattggcg gacagcctgt tgccacagtg 2805421 aaagaataca ctgagcatgc atctatcaca gacggcggaa acgaaacatc agcatcagaa 2805481 atggtacaag cattggtaaa cgactacaaa caaatcagca gcgaatctaa attcgtgatc 2805541 ggcctggctg aagaaaatca agacaatgcg acagcggact tgtttgtcgg attaattgaa 2805601 gaagttgaaa aacaagtgtg gatgctttcc tcttatttag ggtaacaaaa aagctgaacc 2805661 ttaatcgggt tcagcttttt gttttttctt agcttgaact gctttctgtc tgcttggtca 2805721 gtgttgcgtt caacgttttc gtttttccct ttcgcagcac ttggattgtt gttttatctc 2805781 cgacttttaa gtctttgtaa aggatctgac ggatatccgc actgctttcc acgtctttac 2805841 cgtttagttt gacaatgaca tcctcagatt taatacctgc tttttctgcc ggcgaatttg 2805901 cttgaacttc ttttacataa acacctttgc ccaattgatc tccaaacagg ccgagcgtat 2805961 tttcctgata ggtttcagga acttgtgaca tgtcaatcat ctgcacgcct aaaaacggac 2806021 ggtccacctt cccgttttgc agcagctggt caacaatcgg ctcgacatca ttgcttggga 2806081 tcgcaaatcc aagtgattcc acgccgcttt cgctcacctt caagctgttg atgccgatga 2806141 cctggccgct tgcattgatt aatgggcctc cgctgttccc cggattgatc gctgcatcgg 2806201 tttgcagcac gttcatttcc accgtcccct gtgttgtatc cacatcaatt gtccggttca 2806261 gtccgctaat gataccttgt gtcactgtac cggaaaactg ctgtccgagc gggttaccga 2806321 tagcgattac cttttcgcca gtgcgcagct gtgaagagtc accaaagctc gccacttttt 2806381 ttacattctt gccgctgatt tccaaaactg ccaaatcagt aatggtatcg ctgccgacaa 2806441 gcttggcagt ttccgtttct ccgttgtata gcgtaacagt cagcttgttc gcgccttcaa 2806501 cgacatggtt gtttgtaatg atatacgctt tatcgctgtc ttttttgaaa ataacacctg 2806561 acccggttcc gctttcactt tctgagctgg agcctcctcc cgtgccgaat gtgttatttt 2806621 gagaggtttg gatatttgag attccgacaa tcgtaggctc taaatcctct accatatcag 2806681 cgatgtttga tgcgttcgtt atcggcgccg ttgtaaaatt atcagactgc acctgtttat 2806741 ttgcggaagc ggtttcggtc gcctgatttt ggtctgacgg cagataaggc gcgatgccaa 2806801 gcatgaggcc cccgccgata ataccgccta aaatcgggct cagccatgcg gctctccgtt 2806861 tcttttcttt tttcacagcc gtttcttgct tttccatttc taaagcagaa gccgtttcct 2806921 gccgtcccgc ttcatacgac acaggcgcgt caagcaattc ttgttcagaa tgtccaatca 2806981 gcttctggtt ttctgtattc tgctgttctg tatgtgaagg ttcagtttga tgttgatcgt 2807041 tttggccatc acgtcgataa tccatgttct tacactcctt taacggttat tcatttatcg 2807101 ttacatattc atcgcatgta caagttcaat tgtcccaata atgaggagaa aagcaaagca 2807161 ccaaaataga atatgtttga tcatcctaca tcttcctcgc tctttttctc ttcctttctt 2807221 cccttaacca tatcataaac aaacattgtg ggataaaaat gaaaagaata tgtgaaatta 2807281 tgaaaattgc ctgccgtatg ttaaaactag tttataatga cgttgaaagg atgtgaagag 2807341 ccttgtcata caccatttat ctagttgaag atgaggataa cctgaatgaa ctgctgacga 2807401 agtatttaga gaatgagggc tggaacatta catcttttac gaaaggtgaa gacgccagaa 2807461 agaaaatgac accgtctccc cacctatgga ttctcgatat catgctgccg gataccgacg 2807521 gctatacatt aataaaagaa atcaaggcga aagatcctga cgtgccggtc atttttattt 2807581 ccgcccgaga tgcggatatt gacagagtgc ttggcttaga gcttggcagc aatgactaca 2807641 tttcaaagcc gtttttgccg cgggagctga ttatccgtgt gcaaaagctg ctgcagctcg 2807701 tatataagga agctcctcct gtccaaaaaa atgaaattgc cgtctcctcg tatcgggtcg 2807761 ctgaagacgc ccgcgaggtc tatgacgaaa acgggaatat catcaatttg acgtcaaagg 2807821 aatttgatct gctgctatta tttatccatc ataaagggca tccatactct cgtgaggata 2807881 tcctcctaaa agtgtgggga catgactact tcggaacaga ccgggtcgtt gatgatctcg 2807941 tccggagact gcgcagaaag atgcctgaat tgaaggtgga gacgatttac ggtttcggct 2808001 acaggatgat gtcatcatga aaaacaagcc gctcgcgttt cagatatggg ttgtcatatc 2808061 cggcatcctg ttagcgatat cgattttact gcttgtgtta ttttcaaaca cgctgcgaga 2808121 ttttttcact aatgaaacgt atacgacgat tgaaaatgag cagcatgttc tgacagagta 2808181 ccgcctgcca ggttcgattg aaaggcgcta ttacagcgag gaagcgacgg cgccgacaac 2808241 tgtccgctcc gtacagcacg tgctccttcc tgaaaatgaa gaggcttctt cagacaagga 2808301 tttaagcatt ctgtcatctt catttatcca caaggtgtac aagctggctg ataagcagga 2808361 agctaaaaag aaacgttaca gcgccgacgt caatggagag aaagtgtttt ttgtcattaa 2808421 aaagggactt tccgtcaatg gacaatcagc gatgatgctc tcttacgcgc ttgattctta 2808481 tcgggacgat ttggcctata ccttgttcaa acagcttctg tttattatag ctgtcgtcat 2808541 tttattaagc tggattccgg ctatttggct tgcaaagtat ttatcaaggc ctcttgtatc 2808601 atttgaaaaa cacgtcaaac ggatttctga acaggattgg gatgacccag taaaagtgga 2808661 ccggaaagat gaaatcggca aattgggcca taccatcgaa gagatgcgcc aaaagcttgt 2808721 gcaaaaggat gaaacagaaa gaactctatt gcaaaatatc tctcatgatt taaaaacgcc 2808781 ggtcatggtc atcagaggct atacacaatc aattaaagac gggatttttc ctaaaggaga 2808841 ccttgaaaac actgtagatg ttattgaatg cgaagctctt aagctggaga aaaaaataaa 2808901 ggatttatta tatttaacga agctggatta tttagcgaag caaaaagtgc agcacgacat 2808961 gttcagtatt gtggaagtga cagaagaagt catcgaacga ttgaagtggg cgcggaaaga 2809021 actatcgtgg gaaattgatg tagaagagga tattttgatg ccgggcgatc cggagcaatg 2809081 gaacaaactc ctcgaaaaca ttttggaaaa tcaaatccgc tatgctgaga caaaaataga 2809141 aatcagcatg aaacaagatg atcgaaatat cgtgatcacc attaaaaatg acggtccgca 2809201 tattgaagat gagatgctct ccagcctcta tgagcctttt aataaaggga agaaaggcga 2809261 attcggcatt ggtctaagca tcgtaaaacg aattttaact cttcataagg catctatctc 2809321 aattgaaaat gacaaaacgg gtgtaacata ccgcatagca gtgccaaaat agactgtaga 2809381 tgttttgcag tctatttttt tatgtgaaag aatagccgtt aaaatctctg taatttgttt 2809441 tgagcggctg tttgcattga tgaacccatt ttttctctga caaggtctgc ttcggatatt 2809501 tgactttctc cactttgatt cctctgtttc gcaagcggct gatcatttcg tccaattctc 2809561 tcattctaga ttcacccttt cgcttgagct ttgaccattc ggtcatctca atttataata 2809621 taaataatac atgataaaaa aacaagttac aataaggtta attttataac agacggtgtg 2809681 actatatggt catatcctag caggcctccg ggctccgaaa gggtggaacc attgaaggaa 2809741 aaagaaaaac tgattattga aacagcctta aaactatttg cccaaaaagg atacaactca 2809801 acatcagtcc aggaaatcgc aaaagaatgc aaaatatcta aaggcgcttt ttatatttat 2809861 tttccttcga aagaagcgct tcttctctct atgctgaact actattatga taaaacgttt 2809921 acccgaattt taaatattaa aacgaagggc gacagcccca gaacggctta ccgtaaacag 2809981 ctgaccgtcc tctatgaaaa cattcttgaa cacaaagatt ttatcagcat gcagttgaag 2810041 gagggttctc tgccttacac agaagaagtg gagcaatgcg caaaaaaaat ccgccagtcc 2810101 tcacttcaat ttcatatcga cagcctgctg aacatctatg gaaaaaaagc ggaaccgtac 2810161 actgctgagc tttgtttttt aatagagggc atcagccaga tttacctgga atgcatgatt 2810221 ttgctcgggt acactgtgaa gccgtctcaa ttagctgata tcattatgaa tcgaattgat 2810281 gatatggtaa aaggcatgtc tgaacgaaac gataagcctt tcatcacatt ggaagaggcg 2810341 agctctttat tcggacctct tacgcacgga cggcctgacc cgctgactga atcaattgtg 2810401 aaaagcctac gtgacaaaat taacagctta aacacaaact cctctcttga attatcggag 2810461 agcttggaca tacttgaagc agaaatgaag aaaaaaacac cgaagctggc gatcataaaa 2810521 ggaatgattc ataatctgac ggagtctgaa gctctcgcca aagatgcgga acagcttaaa 2810581 tatttattaa aacagcaaca tatttagaag aacggctgct taaaaagcag ccgttcttcc 2810641 tattacgcct ttggttttac catgtcttcc ggcttaacca tttcgttaaa ttgctcctct 2810701 gtcagcaatt caagcttcaa agctgcttct ttgagcgtca atccctcttt atgggcaagc 2810761 ttggcgattt tcgccgcgtt ttcataaccg atatgcgggt tcagcgccgt aacaagcatt 2810821 aatgaatttg acaggttttc ctgaatggtt tctttattag gctcaatacc gacagcacat 2810881 ttatcatgga atgaattcat gccgtcactg agcagctgca cagattgcag gaagttgtaa 2810941 ataataacag gcttaaacac gttcagttca aagttcccct gactcgccgc aaagccgatt 2811001 gtcgcatcgt tccccatgat ttgcgctgcg atcattgtta acgcttcgct ttgtgtcgga 2811061 ttgactttac caggcataat agagcttccc ggctcatttt caggaatgac gatctccccg 2811121 atgccgcagc ggggtccgct tgcgagccat ctgacatcgt tcgcgatttt cattaagtca 2811181 gccgcaagcg cttttaatgc gccatgcgca taagtgattt cgtcatggct tgtcagcgcg 2811241 tggaatttat tcggcgagct gctgaacgtt tggccggtca gcttagtgat ctcttctgag 2811301 acaagctctc caaactctgg gtgggcgttg atacccgttc cgacagccgt tccaccaatt 2811361 gcaagcgcac gcattttatc tgtcgcttcc aaaatcattt ccttcgaacg gtccagcatg 2811421 tgaacccatc cgctgatttc ctgtccgagg gtcagtggcg tagcatcctg aagatgcgtg 2811481 cgtccgattt tgacaatatc attgtatgct tttgcttttt catccagtgt attgcgaagc 2811541 tgatcaagcg ccggcacaag ctgctcgtaa acagccaaaa cagcggcaac atgcatcgca 2811601 gtcgggaatg tgtcgtttga gctttggctt cggttcacgt catcatttgg atgaatcgtt 2811661 tgatcagagt tcttctcttt taataaagca gtcgcacggt tggctaccac ttcgttcatg 2811721 ttcatattgc tttgtgtgcc gcttccggtc tgccatacga caagcgggaa gttgtcatcg 2811781 tacttgcctt tgagcacatc atcacaaacc gctgcaatcg cttctgcttt ttcagcgtcc 2811841 agattgccga ggcgtttatt agctagagca gtgcttcgtt ttaaaattgc aaacgccttc 2811901 acaacacgca tcggcatttt ttcagaaccg atcttaaagt tctccttgct tcgctgtgtt 2811961 tgggcgcccc aaaatttatc agcaggaact tttacttctc ccatggtgtc tcgttcaatt 2812021 ctgtattcca tttatgtatc cctccataac ggttgcttca atagatcata attcgccaat 2812081 gacacaaaaa atccttttta tttttcgatc ttggcagatt ttaattttaa ttcaagatat 2812141 acgcgggaat cctttgaata tttgtatttt ggatttgtcc tgccgtactc ctttgatgta 2812201 taagagacat cataatgctg ttcaaatgat ctaatgagct gttcaatttc ttcttgtttt 2812261 ccagctagcc ttacctgtgc cacttcgtat cctccgcttt cataaaaaaa cttactccat 2812321 gaaatactct aacacagtat atcatttttt taacaggaaa agataacctc tactaaggtt 2812381 ttggataaga ggtgacctca ttggaacaaa cagagtttaa ggaatatata cacgataatt 2812441 tagcattggt gctgccaaaa ttaaaagaaa acgatgatct ggtgaaaaac aaaaaaatgc 2812501 ttgcgaacgg actggttttt tactatctct atttcagtga aatgactgat gagaataagg 2812561 tgtcagaagc cattaaaact ttgattaaag atgaggagac cttaacgctt gaccaggtca 2812621 aaaaacgcct tgaccagctt gacgcaagac ctgttgaaac tgcaaaaaaa acgattgaat 2812681 cgattctcaa cggcaattgt gctgtgttta tcaacggatt ggataaagcc tatattctga 2812741 ccacaggaaa gaaaaaaaca agaagcctga cagagccgac aactgaaaaa gtggttcgcg 2812801 gcccaaaagt agcgtttgta gaggatattg atacaaatct cgctctgatc agacaaagaa 2812861 cctctcatcc gaaattgatc accaaaaaaa tcatgatcgg cgaaaacaag ctgaagcctg 2812921 cagccattat gtacattgaa ggcaaagcaa aaaagtccgt cataaaagaa gtgaaggcgc 2812981 ggcttaaaaa tatccagctg gaagatatcc aggacagcgg aacgctcgag gagctcattg 2813041 aagataataa atattcacca tttccgcaga tacaaaatac ggaaagacct gacaaagtat 2813101 cttcagccct gtttaacggc cgtgtggcaa ttttggtcga cagttcacca tttgtgctgc 2813161 tggtgccggt ttctctcggc atcctgatgc aatccccgga tgactactat gaacgctgga 2813221 tttcagcatc tcttatccgg tcgctgcgct ttgcttctat ctttatcacc ttgtttttgt 2813281 catcgattta tataacactt gtttccttcc atcaggggct gctgccgacc gcactcgccg 2813341 tcacgatttc ggcgaacagg gaaaacgtgc cgttccctcc gatatttgaa gccctgctga 2813401 tggaagtcac catcgagctg ctaagggaag ccggactgcg actccccaat ccgctcggac 2813461 agacgatcgg cctcgttggg ggcgtagtca tcggacaggc tgctgtagaa gcgaatctcg 2813521 tcagttcgat tttggtcatt gtcgtcagtg tcattgccct ggcatccttt accgttcctc 2813581 aatacggaat gggtctgtct ttccgggtgc tgcgttttat ttcgatgttt tccgccgcta 2813641 ttttagggct atacggcatt attttattta tgcttgtcgt ttatacgcac ttaacgagac 2813701 aaacgagctt tgggtctccg tatttttcgc caaacggatt ctttagcctg aaaaatacgg 2813761 atgactccat tatccgtctc ccaattaaaa acaaaccaaa agaggtgaat aatccaaatg 2813821 agccaaaaac agactccact gaaacttaat acctttcaag gtatttctat tgttgcaaat 2813881 acaatgcttg gggccggact tttaacattg ccgcgagcgc tgaccactaa ggctaatacg 2813941 cctgacggct ggatcacgct gatattagaa ggtttcattt ttattttctt catttattta 2814001 aacacgctca ttcagaaaaa acatcaatac ccttcactct ttgaatattt gaaggaaggg 2814061 cttgggaaat ggatcggcag catcatcggc cttttgatct gcggctattt cctcggcgta 2814121 gccagcttcg agacacgggc aatggctgaa atggtgaagt ttttcctgct ggagagaacc 2814181 ccaattcaag tcattatttt aacgtttatt tgctgcggca tttatttaat ggttgggggc 2814241 ttaagcgatg tgtcgcggct gtttcccttt tatttaacgg taaccattat tattttgctg 2814301 attgtgttcg ggatcagttt taaaattttt gatatcaata atttgcgtcc tgttttaggc 2814361 gaaggccttg gacccattgc aaactccctt accgtcgttt ccatctcttt tttaggaatg 2814421 gaagtgatgc tgtttcttcc tgaacatatg aagaaaaaga aatacacgtt cagatatgcg 2814481 tctctaggat ttctgattcc gattatctta tatatcctta cgtatattat cgttgtcgga 2814541 gctttgaccg ctcccgaggt gaaaacgctg atttggccga ctatttctct ctttcagtcc 2814601 tttgagctta aaggcatatt tattgaacgg tttgaatcct ttttactggt ggtctggatt 2814661 atccagtttt tcaccacatt tgtcatttac ggatactttg ccgctaacgg gctaaagaag 2814721 acatttggat tatcgactaa aacaagcatg gtgattatcg gcataacggt cttttatttt 2814781 tctctctggc cggatgacgc caatcaagtc atgatgtata gcgattatct tggctatatt 2814841 tttgtctccc tgtttctgct tccgttcatt ctctttttca ttgtagctct caagaggagg 2814901 attacaacaa aatgaaaatc cggattttat gtatgtttat atgcacccta ttgctgtccg 2814961 gatgctggga cagtgagaat atcgaggaat taagcttagt gatcggaata gggctagaca 2815021 agcctgacga tgaaaattta gagctgacac agcaaattct cgtgccgaaa ataatcagcg 2815081 ccaaggaggg ctcttcatct gatccgacac agctttctat cacaaagggt aaaactgtcc 2815141 atcaaatgat gagaacctct gcattaaagc ataagcctac gttttcacag catttgcgtc 2815201 tcattctgct ttccaaaagc gtgattgcgg atcaaattgg aatggacgcc attattaacc 2815261 agtttgtcag agacaacgga acaaggagga gttcctacgt ctttatcacc aacggccgaa 2815321 ctaaggatat atttaacatg aatgatgaag gcgaacccgc atccaacgtg atatatgatc 2815381 tgacagagaa taataaggtg acgatcagaa cgatggagcc agttacattg ggggagatct 2815441 cagaacactt aacctctgac gattcattcc tcatccctca tgtcggtaag gaaaacggca 2815501 agctcgcgat aaacggagcc tctatcataa aaaataaatt atggcaccgg gacctcaccc 2815561 cgattgaggt tcaaaatatc agcttatttt caggcactgt cgagggaggc gtcattgact 2815621 tgaagcgcga tggccatctc ttttcttatg aagtatattc aagcaatcgg aagatcaaga 2815681 cggcatacaa ggacggaaag ttcaaattca ccgttacccg caatattgaa ggtcgtctat 2815741 ctgaggactg gaatcccaat gaagactcgt ttaaggattc atatattaaa agtattgaaa 2815801 agacagtcga aaaacgagta cacgaaacag taacgtcatt tattacagag aagctgcaga 2815861 aagagatcaa agcggacgta accgggctgg gaaacgaggt cagaattcat tatcctcaaa 2815921 agtggaaaaa gatttcaaga aaatgggatg atgattattt cagcaatgcg gaaatagact 2815981 accgggtcaa tgtgattgtc agagacttcg gaacgaaagg cgcaaacaaa tagcagccgc 2816041 ctaattcacg agatgatttc ggtgtgcgta caccgccgcc tgcgtccggt cactgacatc 2816101 cagctttgat aaaatattcg taatatgtgt tttgactgtt ttaatcgtaa taaacagttc 2816161 ctcgcctatt tctttgtttg tctttccttc tgcgatcagg cagagtattt cgagctcccg 2816221 ttttgtaagc gattcatgcg ggagcgcgtt ttcacctgag tggcgcagcc tggataatac 2816281 ttttcccgcc acttttgact ccagcttcgg ctctcccttg cttgcggcgc ggatggcatc 2816341 ggcgatttct gccgcttttg aggttttcaa cagatagctg agcgcgccag cttcaataac 2816401 cgggtacact ttgtcatcat caatgaagct agtgagcaca ataattttcg ggtcggaaag 2816461 ctcccggcaa atttgctttg tagcttcaat gccatccatg ccctccatga caaggtccat 2816521 taaaatgaca tcaggcgaca gttccacagc aagccgaaca ccttcgctgc cgtccgatgc 2816581 ttcgccgatg acttcaatat cgggctgcgc ctccaaaaaa gccgcgagcc ccattctgac 2816641 catttcatga tcatcaatca ataatactcg aatcacgttc gttctctcct ttttcttccg 2816701 gaaaaatcgg gaccttcact tcgatttgag tgccttttcc ttctactgaa atcacttcgg 2816761 cgacaccgcc gatttcactt gcacgttctt tcatagaatt caagccgtat gaggaggctt 2816821 tcacctggtc cattttaaag ccttttccat tatcaatcac cttcagacgg agctggctgt 2816881 tctttatgcc cagaatcacg gttacttttg acgcttttga atgtctaaat acgtttgaaa 2816941 gggcctcctg cacgattctg aacaagtggt cttcaacacc cttggatatc gctgtgtcct 2817001 gtatatccca ctcaatatca atcggctgct tttttcggaa ctcgtccaaa agctccgtaa 2817061 ggccctcctt cagccctttt ccttcaaggg taacaggccg taaatggagc agcagcgccc 2817121 tcatctcatt ttgggcttcg cctgccatat gctcgaccat cctgatccgc ttgactgttt 2817181 tgtcatcagc atccttgaca tgttccagca cggctgatgt catcatcgat atggcaaaga 2817241 gctgctggct gaccgcatca tgaagatctc tggccaatcg ctggcgttct tctgagataa 2817301 ccgacttctt catttgagcc tgccattccg cacgttcatt ggaaagtttc tggagggatg 2817361 cgacttgaag ctccacgcgc ttcgccattt cgttcagctg atcagcagcc aggccgattt 2817421 catcatcacc gagcggcggt atccgataag cgaaattgcc gttttcaaag gttaaaatgg 2817481 attcaattaa tgtatcaatc cttgtcttca accggttgcc gtacatatac cctgaggcga 2817541 aaccgacggt cacgctgatc agaagcaaaa tcaggataaa cggaattccg aaccagcttg 2817601 atgacagcaa aacaagcgga tcgagccgat agtaaaacat cataaaggaa atcaggcaaa 2817661 caaaaaggag caggctgatt cccgttgtca tgcggatggc gcgccattgg aggctggcaa 2817721 gcattttttt tctcatacgt acttcacatc cacatcaccg ataaataagg aaacggacac 2817781 ttttacccgg cgctttgact cgctaaaatc agttgacgcg gcatatacct tcgtgcttaa 2817841 tccgcttttc ttcgagccga tcagattaat gtctcctata aaaacagccg agctgacagc 2817901 cacttcaagg tccgatggta cataaatatc aacgttacca atgactccgc taatgacgat 2817961 tgtactttct ccctcgggaa tcatcgcttt agataaatcg attttgatat caccgataaa 2818021 accagagaca tttaaatcgt tcaggtcaaa cggctgcttc atcatttgca gctcaccgat 2818081 aaaaaagctg cgcatgtcgg gatgttttac atcttttggc ggctcatgat gttctttttt 2818141 attgagattg acctgtttct cattcggttc aaatatcggc ttccctttga taagcctgta 2818201 gccggcgtaa atcagaaatg cggcaaacgc atagccgaat aaattaaagg tgatgctgaa 2818261 gaggtttttc aaaaatagaa acgcggcaaa gatatacatg acggagccaa gccaatcacg 2818321 ggaatatttt ttaaggaaat agccggcaat cagaaaaaag agcggccaaa acagcagatc 2818381 gcctattccg ataatttgca aaaacatact gatgccgaat aaagcaatga tcaatccgag 2818441 aagctgtttt tttgtcattc ctggtgtccg cctcctttct tctgcctagt gctaccgtat 2818501 cgctagatcc ccgctgtccg ttttgatgtc gattggatgc cggccgcttc cttgcgtgcc 2818561 tgtgatgtga tgctgttctt tatgtccttt atcagcaaat gaatacggcg aactgacgtc 2818621 accgcttgct gataaagcat tgactgcaaa gctgccattt tggggaaggc ttacattagc 2818681 atcaccgctt gtcagcgtga cagatacggg accggttacc tttttcaata cagcattaaa 2818741 atctcctgaa gtcattttca catcaagaga gcctgataca tgaaccagat ttgcgtcccc 2818801 tgaagctaaa tcaatgccgg ctgttttgga gacggtattt gaaatggaaa catcccccga 2818861 tgatgccttc actttcagat cttgaatgcg gacgtccgtc acgctcgtat ttccgctcgc 2818921 agatactgcg ttcagcccgg aaagcgcaag atggtcattc ccggccacag acacgtcacc 2818981 gcttgaggtt cgtactgcca gatcaccttt ataatcatac ggaagcctga cgataagagt 2819041 tgaacggtta aatccattca aaaattgaaa ttctttttcc tttacggtca gctccagttt 2819101 tcttttgttt tcagtaacaa ataactttcc tgagtctcct gaaatgcctg ccgatatgtc 2819161 acttcgttct tccgctataa tccggacatc cttgctatcc gactcaatga ccatgctgtc 2819221 aatgtcccgc ggcgatgcgc tggctgaatc agcttctgtg ccatttatga aacctaggcc 2819281 tgcagcaaac acatctttta cgacgacggc gaaaaaaacc agaataccgg cagtgatcaa 2819341 cagtttgcca agcatttttt tcattcggtt tcatccttct cattcattct attataaagg 2819401 aaaagcttgc gaattgatac gtgcggaagg gaaggacttg accgcaaatc cttccccgtt 2819461 ccgcttattc atttgccgct tttgtctggt ctgatttttg cagtgaaagt gtccgcattt 2819521 tttcaatctc cgcttccaca tcgtctgcga attctttacg tgtaagttct gtgccggctt 2819581 ccgctgactt tgaataattc gcgcggattt ccatttcttc aatacgattt tcaatacgta 2819641 aaaattcacg atacgcgctt tcactgtcaa ttttgtcaaa tgtcgtattc atatgctctt 2819701 tagctttcgc cgcatttgcc cgcgcaatca gcgcctgttt tttatccttt acgtcctgaa 2819761 gctttgtttc aagtgcagcc agctgctctt tcagatcagc cagctgactg tttgcctgtt 2819821 cataggaagc tttatgctca gccgccttcc cttctaaata cttcatttca gtcagcgcct 2819881 ttttcgccag ttcttcttca cctgcgtcaa atgcgagctg tgcctgattt ttccgtttgc 2819941 cagccacttc agcggcttct tcatattttt tcttaaattg ataggcaatc gtgtgctgtt 2820001 tcacaattgt ttgctttgct tttgcgatgt cgctttccat atcgcgtaca tattgattca 2820061 gcatcacctt tggattctcc attttatcaa gtccttcatg aactgacgca acaaacatgt 2820121 ctctgattct ttttaatacc atacctgatt cctcctaata tattgatatt attttttctt 2820181 caaaaattct tcccattcgt catcaaagtg agattggtag gcagcagaag ccggttcagg 2820241 atcaaaagat gatacaccgt tatcagctga tccgtttttc atcagcttcc agccgtaata 2820301 caccatagcg gccgccaatg cgattccgac gacaaacgga agtgagcaga tgagcataat 2820361 ggctccgata ccgcccacga tgattcccgt gatggttttt cccgcggcaa accttttgat 2820421 tcctgcgtat gtcatcaagc tcccgatggc gagcgggatg ataaagccga agcttcctcc 2820481 tccaaaaaag acggagatcc caaatacaat taataagaat ccgcctattg ttttcttgtt 2820541 tattttcatg cagatcctcc tttcgttttc cttgtcttca tcttatacaa gttggaagat 2820601 atgcaaaacg aatcagagat tgatttttat ataagaccgg agtcgtatct cgcaccggac 2820661 ccattggcac aaaaaaacgc catgcacgag gcatggcgtt ttaaaaccct ttacagatga 2820721 acacttgctt ccctttcttt aattaggtcg gacctttctg ctttggccaa ttttgtaaac 2820781 agcaagattc cgatacccgc aataatttcg acaatcccac cgacagcgat cactttacct 2820841 gagccgaaag cattagcggc atacccgcaa atgacagctc cggcagggat cgaaatattt 2820901 gagatcatat gtataacggc gtaaacctgc ggctgatcct cactatccac agacgtctgg 2820961 ataatcgtgt actcaggaac attaacagca ctgactgcgg caccaaaggt aaaagcagcg 2821021 aaaaagacga gcggcaaaaa ggtattcatc ccggtaataa agaaagcaaa tccttcaata 2821081 atgccggcag tgacgaataa caagccgtac ctgtttacct tgactttcgc cagcacaaac 2821141 cctaataaaa acgcgcccgc ggcggtggtg gcctttaaaa gcgagtatac gatcggctgg 2821201 ccgtttaaat cttccgcaac gtatacggca gagagcgctt cccatggggc agccgcgaaa 2821261 ttcataaaga tacagtaaat ggcgagcgga tataaaatct ggtgttttct gacgagccta 2821321 aagccgcgtt tcagtcttcc gatatatgtg cctctctgtg taacaaccgc agactctgat 2821381 tgagattcaa ccgcagtgta cttaataaaa agaacgagaa aacctgacac caaatagagc 2821441 acaagtgcga taagcatggt ataagaagga ctaataaatg taagaaaagc gccgcataat 2821501 gtgacagccc caagccggac aatttgagcg gaggattgca gcacagcgtt tgctttttga 2821561 atgccctgtt cattgacgat ttgaggaatc aaagcgatag aggcgggatt gtaggcagct 2821621 ccagtagctg aatgcacaat cataagcgtc atgacaaacc acagcggaga gaagcccgca 2821681 aaatgacata gagggataat caaaacaatc gccgcccttg tcagatctga aaagtacatc 2821741 caaaatttca gcgtggtctg tttcataaaa ggccccgtca caggcgccag aacggcttcc 2821801 ggcaaaaacg tgacagcaat caataaagca gtgccgatcg cacctttgcc gtcataaatt 2821861 aaaaaccata atattgaatt aaatgcgaac atatcgccgg atatcttgac tattcttgag 2821921 aaaaacagat aattgaaatt tctcttccag atgctatcac tttcaattaa attcaccatc 2821981 catcagagcc ccccgttgcc tattttttac atctatttat tacaatatct catttttcca 2822041 tttttcagtc aataattcat aaggttcatt ttttgtcgta aaatgggaaa ttgacagagt 2822101 gaaaaacaaa aaaagccggc atgtatttga acacgccggc tttccttttc actttttatg 2822161 attcgctgct gtttcggtcc cgaaacacaa tggcacttct ttcatattct acatcgccaa 2822221 taccgcttct tgcattcaca acccgggcgg cggcaaagaa ataatcggac agacgattga 2822281 gataacgcag cactgtttca tgaatctcct ccgatttcat cagcgccacc actcttcgtt 2822341 ctgcccgcct tgtaatggtg cgtgcgatat ggagaagcga agcacacttt gatccgcctg 2822401 gaagaataaa tttcttcagt tccggcgctt ctgctgtata ggcatcaatg cgcgtttcta 2822461 aaaaggaaac agattcttcc gttagtttat agtcttttct ttctgtgacg attgccagat 2822521 cgcctccgca gtcaaacagc tcatgctgga tggtcagcag ctcggctgtc agatcttcaa 2822581 agccgggctg cccggaaagc tctgccaaag caagcccgat aaagctgtta agctcgtcaa 2822641 tcgtgccgta gctttcgacg cgtaggctgt ccttgtccgt tctgcccccg actaagcccg 2822701 tttgtccctt atcgcctgtt tttgtatata gtttcatacc ctgaatctcc tttacagact 2822761 tattcaaaca actcagcagc ctcttttata cattcagctg tccctttctt tatcaattgg 2822821 ttcagccgct gttctatgtt ttctgattgc tgagtttgag tcgcggcgat gagaatatca 2822881 cctgtgcctc ctccgtctcc cagcactttc gtccgttctg cttcggcagc cataagagct 2822941 ttgatgaaga attgatctgc cgcatagccg ttaatcaaaa tccaaatcga aaagccggtc 2823001 tgaacgcata tgaaaacgga taactctccg tcttcatatg ttcgatacac gaaacggtca 2823061 agtctttctg aagaagccat cgcacacgtc tcctgcagtt gaaaaccgct ttctgaaaga 2823121 caggccgtaa gtccttctat cggatctggc tgatctggca gccgtttatg gatcagcgtc 2823181 ctgctccacg aaaaccctgc accgataggc gtggaggaca atgttcgaag cgggatttcc 2823241 gtttgcagaa gaatgtcatc acgccccgct tggagcaatg cttcaaatgg gatagactgc 2823301 cgcttcacgc tatctttttc aggctgaatc acaatcatcg gtttaggtga gctttgatga 2823361 accaaggcgg tgacatctgt atcgtacacc gcctttatgc tttgttctgt aacagcatat 2823421 tccggttttt gcttaggccc ggcggtaccg tttttcataa acatgagccc atcacagtac 2823481 aggcttgcgg tgttcagatc atgaaaaacg ctgacagctg ccaatccgct ttctctcgtc 2823541 aggcgtttga tcagatcaag caggtctttt tgataagcca gatcgagaaa attagtcggc 2823601 tcgtccaaaa ataaaatacg cggctgctgc gccaaagctt gtgccaaata cacccgctgc 2823661 tgttcccctc cgcttagttc gcgaatcggc ttttgcgcaa aatcggccac tcctgtttgc 2823721 tccattgctt cctgtacaat ggcttcaccc ttttcagtct gctgtctgaa cagccccgtt 2823781 tggaatggat atctgccaaa ggctacagtt tcttcgacag taaaggtgaa ggcttgatcc 2823841 attttttgcg gcaggacagc catgatttgc gccagttcct tcggtttata gtccgccagc 2823901 agttttccgg ccagataaac cctgcctttc ttggccggca gcgtacctgt cagcaagtgc 2823961 aaaagcgtgg tttttccgct tccattaggg ccgagaattc caagaaattc tcccttctcc 2824021 actgttaagc tgacattgtt gattaggcgg ctgtcgccgt atcctcccga cagcccttct 2824081 gccttcatca taagcttctc cccccgcgat gctgccgaat taaaataaga gcgaacacag 2824141 gcgctcccgc caaggacgta atgatcccga tcggcagttc aatcggctca atgatggttc 2824201 tggaaagcag atcggctaaa acaagaaacc ctgccccaag caaggcggac aacggcagta 2824261 aatgccgatg gtccgttccc cacaaaagcc ttgtgatatg cggaatcaca aggccgacaa 2824321 agccaatcgt acccgatact gccacagcgc ttcccgtcaa aagagatccg gctattaaaa 2824381 tcatcatctt cctctgctga acgctgactc caagaagctt tgctttatct tctccatatg 2824441 tcatcacgtt cagttccctt ccgtttataa tcaataaaat ggttcccaaa agaaaaaacg 2824501 ggagaaacaa aataacatag ctccagcccc tcattgagac gctgccaagc agccaatgca 2824561 caatcggaag caggttgtct cctgtcaagg cgatgataag agaaataaat gcgcctaaaa 2824621 aagagttggt gatgacaccg gtcaaaatga gggtggaaac agacatcgaa gcatgaacga 2824681 ggcggctgaa gaaaaggacc gccgccatcg tggccagtgc cgcggctaca ctcaaaaccg 2824741 ggagtgtaaa ccctccgatg acaggaaggt gcaaacctaa gaacagagtc acaacagctc 2824801 cgactgaagc accggatgac acacctagcg tatagggatc agcaagcgga tttttcaaca 2824861 atccttgaaa agcggcccct gcaatagaaa gagccgcccc cacaagggcg gccagcacaa 2824921 ctctcggcag tctgatattc atcataatat tagtgtacat cggatcatca gaaccgatag 2824981 agccgccgaa accttgatgc caaaagacac gaaaaacagc gggaatagga atatgcaggc 2825041 tgccgcaaga aattcctaag atgatgctca cggctaaaaa tgagaaacca atgatatatg 2825101 cggcataacg attattcctt aaacgtatcc gggtaaatgc tttccgcaag ttcttcgacc 2825161 ccttcgatca gacggggacc ggaacgtgtc acaagatcag ggtccacatc atatacacga 2825221 tgatgtttca cagcattgat ttcgctccag ccatcgcgtt tttccacagc tttcgctttc 2825281 acaccgtccg ttgtaacaat tgcatcagga ttgagtttta cgatcgcctc gtctgtcatt 2825341 tgcacccatc ctgtctgatc cgcagctgcg tttttagcat ggatgacatt tagcatttca 2825401 ttcataaacg tatcttttcc ggttgtataa atgtcaggat caggagaaac ctcgataaat 2825461 acgcttttct cctcgtcttt tgaaatggtt ttcgcttttt cttgaatatc ctttagatct 2825521 gatttcatgc ttttcacgag ctgatcggct tttttctccg ccccgccagc ttctccgatc 2825581 atttcgattg atttgtacac ctcggagaat gattgtgcat cattgacagt cagcactgta 2825641 atgcccgcgt ccttcagctg tttgatggca tccgctgatg ctgacatgga agactcatgg 2825701 gccagaacga gatctggttt tagagaaatg actttttcaa cgtttacatt catatctccg 2825761 actttctcaa cctttttgac ttcctttgga taggtatcgt ttgtggtgac accgaccact 2825821 ttgtcaccaa ggccgagtgc gtatgtaatt tctgtgttgc tcggcattaa tgaaacaatc 2825881 ttttttggct cttttttgat ggttacatct tggtttgacg catcatcaat ggtgacaggg 2825941 aacacttctg ttttttgttt tgcctttgaa tccttctgat ccgcaggatt gccgcagcct 2826001 gccagcataa cagcagccaa cagaagcgca gcccatatcc cggctcgttt tttcataatc 2826061 ttttcctcct aaacgaacta aaaaagcatc tctacgacgg taaagatgct gtaaacaaca 2826121 caaaaaagcc tattgtttac acatcatctg tcctcgcaga attcgtgctg atcaaacagg 2826181 caggtatcct ggctcttggc gcttggccaa ttacagtggc gggaccgcac cggcttttac 2826241 cggtttccct tttaagccgg ctgttgttca cggaccggca cctatttgac attcgtatcc 2826301 gtttttcgga gtaattatac tatatgactg acaggcttgt atatgtgtcc tgaatgactt 2826361 ttccccatat tgtgtatgga agcaaaatcc tcgtaaacac taaatttgat cttgtatact 2826421 taataccatc atctatcaaa aggaatgatt cttatggatt tacagctaaa agaaaaactc 2826481 gtcttaatca ccggctcgac gtccggtatc gggaaagccg ccgcaaaaag ctttctgcaa 2826541 gagggtgcgg cagtcattgt caacggacgc aaacaggaga ctgtcgatcg caccattgaa 2826601 gagctttctg gctatggaac agtgcacggt gctgctgccg atttgtcaaa aacagatgaa 2826661 gcagcggctt ttatcgaaaa agtaaatgaa atcggtgata tcgatatcct tgtcaacaac 2826721 cttggtttct tcgaggtaaa agacttcgcc gatgtgacag atgaagagtg gaatcaatat 2826781 ttcgaagtga acgtgatgag cgccgttcgg acaagccgtc acttccttcc aaaaatgctt 2826841 gccaaaaaca gcggccgcat tttaaatatt gcaagtgaag caggcgtcaa accgctgcca 2826901 acgatgattc catactcaat gacaaaaacg gcactgatca gcctttcaag aggaatggct 2826961 gaaatgacaa aaggcacaaa tgtgacggtc aactcagtgc tcccgggacc tacttggaca 2827021 gagggcgtgg cctcctatat ggaaggcgcc gcacaagcag ccggacagga tacagataca 2827081 tttatcaaag actatttcaa ggtcaatgag ccaacctcac ttattcagcg atacgcgaca 2827141 gcagaagaag tcgccaacac aatcgtattc ctcgcgtctg acgccgcatc cgccattaac 2827201 ggcacggcac agcgtgtgga aggcggcatt atccgttctc tgtagtataa aaaaacgcat 2827261 ccgtgtttcg gatgcgtttt ttttatacgt ctccagcaaa tggtaccggc tgatatccgc 2827321 ctgtttccag ttgtgctgaa aacaaccctc cagcgtgagg ctgctcgtat ctctcttttt 2827381 ctgtcatttg ttctgttgcc gttgtaatgt aaagggtttt taagtctctg ccgccgaacg 2827441 cgcagcacgt gacatattta gccggcacgc tgattgaatt gatttctttt ttctgaaacg 2827501 ggtcaatgtg aacaacgcgg ctgccgccaa acagcgccac ccacagcatg ccattttggt 2827561 caattgtcat gccgtccggc aatccgtctg actgatcaaa acgatagaca ggttctggat 2827621 tcgaaacatc tccgctttga ggatcatagc tgtaacgtac aatctcctgg gtcggcgtgt 2827681 cgatgtaata catcaaattc cgctcgcggt cccaatccaa accgtttgag gtggagactt 2827741 gatccttgat tttgacaaga ctgccgtcta gattcaaacg gtacagcgac gcctgttttt 2827801 gctcgccttc catgctcgtc gtccccgccc aaagccttcc gtacgggtca catttagcat 2827861 cattaaatct caggctctca tgcatgtcct tcggctgttt aattttttcc aagctgtcat 2827921 cccgaagatg atacaggtaa aacccgtcct tcatcgtcat aatcagttca tcctttgaat 2827981 atttcgcaag cgccgtcaca aaggatttga atttgattga tcggttgatt ttttcttcag 2828041 ggtcaaagat gtggagctcg ctccccagga tatcaaccca atataagcgg ccgttctctt 2828101 catcccataa cgggccttca ccaatcactg cccgagtgtc tgcttccaat actgcatcca 2828161 tgtgttacac ctctttagct tcagtctata tattgttatt cccggcaaag aggtgtccaa 2828221 accacttgat gtttattgtt ttttaaaaag gatggtaatg accgttccaa tgttcgttct 2828281 gctgttcaca tggatcgttc cgttatgcag atggacaagc tccttggcaa tcgcgagccc 2828341 gagacccgtt ccggcagttg aatcttttgt gttcgtccct ctgtagtagc ggttaaacaa 2828401 atgggtgatc gtttcttcat ccattccttt cccattgtcc ttcactttta aagaaatatg 2828461 attttttgtt tgctccagaa tgacttgaat ctctgttcct ttgccgttgt gcttcacggc 2828521 attcccaagg aggttttcta atatgcgcct gaaccacgct tcatcaaggg caaattcaat 2828581 atgctcttct ttggatacaa acgagatatc atagccttca gaaaacggat ttttcttaaa 2828641 atcctcaatg acatttttaa aaaacgggat aaggctagtg agctttctct caataggaag 2828701 agcatcattt ttcaggcgat acgttaaatt taagtcttca atcagcttag acatgtattc 2828761 agatttttct ctgacaacct gccccatttc tttcacttct tccggcgacc agtcatactg 2828821 cttcgactcg agcatcatgc tgtagccgta aatgctgctg agcggtgttt ttaagtcatg 2828881 tgacaaaccg gcaatccatt cttcccttgt cgcctggatt ttttctctgt ttcttttatc 2828941 ccttctcagc gtttcagtca gctgatccat tgattcaaat atctcaccga agaagcggta 2829001 cggctgtttg atttttccct ttttattttt gctgacagga cggccttccc ggtttctggg 2829061 ctcctcaagc ttcccttttg acagattgac cagccatcta atcgtgtgaa aaatcggcag 2829121 cccgaatcgg aacatatacc aaacggtcat ccaaatgata tacatgaaca aaacggccat 2829181 cacgagaaac atcgctttta atacaacctt caggaatgat ttgttaaact cctgatcggt 2829241 tacatagact gggttcggca ccgtagcgac catccatctg tctttattga ggatcttaac 2829301 ggaaatttcc cgcttatagt tccaaggctt agagctgtat ttaagcagct ccagctggtt 2829361 catcgttttt ctctcgcttt ttgtgctgtt gatgctgtcg agaatctttc cattgctgtc 2829421 taacaggtaa atggcgcctt ttttccgttt aatatagtcg atggtactag acttatagtg 2829481 cgctagtgag tctatctttt gttcacgctt ttcaacggaa gtcaggagct gttcactttt 2829541 tgatttccag ccggacaata gaagatacga cttatcttca atattgatgg cccaataatt 2829601 cagtttatag ttatgaagct ttttggtttt ataaatagac aaaagctctt tcttggtata 2829661 ggtgcccggc acgtcttttg gcacgccgta ggaataatca gtgtttcctt ccgaatcaat 2829721 gatttgcatc cagccgtgct gtttatcaac agatttcttc aggaaattat ccacttccca 2829781 tgtcccgtct tcgtttacat cgagatatgc ctcaagtgtg tcggtcgttg ctttcgtcag 2829841 ccctgaattg gattccgcat cgctaaaacg ggcgtctaaa tagaaaaacg atgcaacaag 2829901 cataaccgta agcagcagga tcacaatcag catctggccg aaaaagtgaa acaaaaactt 2829961 ccatcttaac ctcatgaccg cttgccttca ggatttggga taaaacgata gccgagacct 2830021 cgaacggtta caatatactc cggattgctc ggatcgcgct caatcttctc cctaagcttg 2830081 cgaatatgaa ccatgacggt gttgttgtca ccgtaggaag gatagcccca tactttttca 2830141 tatatttgat ctttggaaag caccacgtta gggtgttcac aaaaatactg caaaagctgc 2830201 agaagctggg ctgaacaggc aacggcttcc ccgcctacga tcaactcggc attttgcgga 2830261 gaaaaagtaa agtaatcata tgtgtaggtt tgatttgaac tcgtttcttt cgattgatat 2830321 gtacgcttga gatgcgctct gatccgcgcc gctaattcca gcggattaaa tggttttgtg 2830381 atatagtcat cagctccaac cgcaaagccc gataatttgt ccgcgtcgga tgatcttgcc 2830441 gtcaggaaaa aaatcggagc gtctgaatac tctctgatca atgtgcaggc ttcaaaaccg 2830501 gacattccgc ccatcatgac atccagcaca atcaagtcaa ccttattggc cttcacaacg 2830561 ggaatcgctt cttctgcgct tgccgcatcc agtatatttc gataaccttc tttttcgaga 2830621 acgcgtttga tcatgtccac aatcgctttc tcatcgtcta cgattaaaat tgacgcattt 2830681 tccactttta tgttcctttc tgtcactgtt tttttcatct tatcattata tcgtttattt 2830741 atggtacatt tttgaataca ttggagcctt ggcaaatcaa aacagcaaaa aaggagcaaa 2830801 caagcgctcc cttttgatgt tttttcatat gaaaatatta tgagttctca tctaccatgt 2830861 acaaaataaa ctcccaaaac cccggtacat cctgacataa aagcatatca gccttttcaa 2830921 acattttgat cttcagctct tgctctaaat cttctctttc ttgataggac gtattgctga 2830981 gtttttttct gatcatcggt gaaaagcatg caatcaggtg ctcaatgtca taagtctcgt 2831041 ctttttgttt ctttttttgt tcaaactggc cgtccacagc ttacttttcc cccttttttt 2831101 gcgccgctaa ctgctttctg atattctcca gccccttttt atgaatgttg gagatgtttt 2831161 gtcgggactc ccctaatgaa tctgcaatct cctgcatcgt ggcaccgtga agatagactt 2831221 tcgtcagcac acttttttgt ttgtcagtca gcttctggat cgcttggtag agctggtaat 2831281 cctgtacatg ctggctcaaa tcatcctgcc tgtctaaaaa ttcttcaaat gcatcgctac 2831341 ctgtttcgga agaaagccga tctcccgcct ccggatgatc aaccgtcagt ggataccgtt 2831401 tttggttttt gcgaacccgc ttatcaaaat caatagaaaa gatgcgaatc attgaattca 2831461 tatacttgac gatgcggatt tctttataaa attgcttaaa tagctcgtcc aatgatcttg 2831521 catctttttc gttagggctt tccattacgt ttttgaacaa acggtaatgc tgaggattgc 2831581 tcaaaaaatg cttcacgatg ggatgcttca ttatctcctt acattttgac cgtaaaagac 2831641 tttgatagtc catcaaaccg cctccctact aaattaaatg aaggaaagca aaaaaaagta 2831701 aactactact ttccgcctag tgtcttccaa aatactttgc agcagtttac gttttatcgg 2831761 ttttcctcac ttacatacat gactgcagaa aaagaaggga ggtattttcc tatggatcag 2831821 gtttttatag aggaagtcgt aaaacagatc ggcaatttgg ggtttcccgc gctgattgca 2831881 atgtatctgc tgacccgatt cgaaaagaag tttgatcaac taatagaact aatgacagaa 2831941 ctgaaagatc atgcaaaaaa ataatttttc aatcgaagtt gacttttcac tggttttttt 2832001 cacttaacaa aacagaaggg aaaacgaaag gcctttcacc ttctctttct gctatcacat 2832061 ttaaatgtaa ggaggaaaca tttcatgaaa aaacaaaatg acattccgca gccaattaga 2832121 ggagacaaag gagcaacggt aaaaatcccg cgcaatattg aaagagaccg gcaaaaccct 2832181 gatatgctcg ttccgcctga aaccgatcat ggcaccgtca gcaatatgaa gttttcattc 2832241 tctgatactc ataaccgatt agaaaaaggc ggatatgccc gggaagtgac agtacgtgaa 2832301 ttgccgattt cagaaaacct tgcatccgta aatatgcggc tgaagccagg cgcgattcgc 2832361 gagcttcact ggcataaaga agctgaatgg gcttatatga tttacggaag tgcaagagtc 2832421 acaattgtag atgaaaaagg gcgcagcttt attgacgatg taggtgaagg agacctttgg 2832481 tacttcccgt caggcctgcc gcactccatc caagcgctgg aggagggagc tgagttcctg 2832541 ctcgtgtttg acgatggatc attctctgaa aacagcacgt tccagctgac agattggctg 2832601 gcccacactc caaaagaagt cattgctgcg aacttcggcg tgacaaaaga agagatttcc 2832661 aatttgcctg gcaaagaaaa atatatattt gaaaaccaac ttcctggcag tttaaaagat 2832721 gatattgtgg aagggccgaa tggcgaagtg ccttatccat ttacttaccg ccttcttgaa 2832781 caagagccga tcgaatctga gggaggaaaa gtatacattg cagattcgac aaacttcaaa 2832841 gtgtctaaaa ccatcgcatc agcgctcgta acagtagaac ccggcgccat gagagaactg 2832901 cactggcacc cgaataccca cgaatggcaa tactacatct ccggtaaagc tagaatgacc 2832961 gtttttgcat ctgacggcca tgccagaacg tttaattacc aagccggtga tgtcggatat 2833021 gtaccatttg caatgggtca ttacgttgaa aacatcgggg atgaaccgct tgtcttttta 2833081 gaaatcttca aagacgacca ttatgctgat gtatctttaa accaatggct tgccatgctt 2833141 cctgaaacat ttgttcaagc gcaccttgac ttgggcaaag actttactga tgtgctttca 2833201 aaagaaaagc acccagtagt gaaaaagaaa tgcagtaaat aaaagacttg cggcttgcag 2833261 agagcactcg ttctctgcaa gccttcataa ggagctgaac cagtgaaaca tcaaaaccct 2833321 tcaaaacgct tattgcggct ctccataaag tacttgctgg ccgcagcagc agtggtgttg 2833381 acctattttg ctgtcatcta tatattgttt tctttagcgg gaacgagcta ccgctcagca 2833441 gctcatgtcc tgctttttgc cgtggtattc cttgttctcg gattatgctt tgaaccattt 2833501 gaacggctga tgatacatag ctttacattt ttcaagacag gaaaacgtct attcattctc 2833561 cttgctggca tcgtacagct gctgtttttg tggatgactg ctcatacaac agaccaattg 2833621 atcagcgaca tctggctgtc caccacagaa gaaatgattg tcgcagccgt ttttttgatt 2833681 ttagacaaat gcaactcggc tcttcccagc taaaaaaaga acgcattcca attggatgcg 2833741 ttctttttat tcatagcgaa gcgcgtctac aggctgaagc ttcgaagcct tgatagacgg 2833801 aagcaagccg aagataatgc cgactgccat tgaaaagatg agtgctccga caacagctgg 2833861 aatggagacg ataaaaggca tcggaaaaat gaccgtcagc agcttggcga tgccgaagcc 2833921 cgccagcaca ccgagtattc cgccaatgct tgtcagcacg acagcctcgg ttaaaaattg 2833981 aaataaaatc acacgccgct tagcaccgag cgctttctta attccgattt ccctcgtgcg 2834041 ctccgttacg gaaacgagca taatgttcat gacgccgata ccgcccacca aaagtgaaat 2834101 actggcgata ccgccaagca gcaatgcaaa tgactgatta aaggactcca cttcctgcgc 2834161 gatctcctga agatccatta cactgtactc tgctttttcc agctcagctt ctgacagtcc 2834221 ctgatttaaa agatctgcag ccattacacc cgcttcttgg atatgctcag aagaatcagc 2834281 ctgcacggca atctgcgttg gcgcgtcaaa tccttcaata agcggccaca cttttttcgg 2834341 cacgtacaaa accgggttcg catagtcgcc ttcaaacatg ctttcctgtt gatttttttc 2834401 tttaaaaaca cccacgacct taaacggcac accattcatc tcaatgcttt tatgcagagc 2834461 ttctccgtct ggaaacagtt catctctgac agcttcattg atcatcacta cttggtgtgt 2834521 gctgtttaaa tcgttttccg tcagctttct cccttcggtt attcggattg gaaacatgtc 2834581 gaagtaatca tcgtccactc catacacttg gggatacgaa acgttagtta aatgaaaaac 2834641 gctcgcgcct tctgacaagt aatataagga taatcctttg accatcggat ctgatttgat 2834701 cgcctttact gtttcttccg ctacaggcgg cgcggacgca tacgacacct gagggccgcc 2834761 gctctcctct tctccgccag acggctggta gacaacattg atggcgttgt ttcccatgcc 2834821 gatcatactt tgctttaact gctcactttg gcccttcagc attgaaacaa tcgcgatgat 2834881 tgccgctatg ccgataatga cgccaagcat tgtcagaatc gatcttaatt tatgagagaa 2834941 aatggattga aaggagattc gaatatgttc aagcatggct gatatcccct ctctcatcta 2835001 ataccaactc tccgtctctg ataaaaacgg ttctgtcagc ttttttggcg acgtccgggt 2835061 cgtgggttat cataataatg gtcttgcctt cccgatgcag ttcagaaaac agtgccaaaa 2835121 tttgttcact tgatttggta tcaagcgccc cggtcggttc atcagctaaa ataaacctcg 2835181 gctgattgac aagggccctc gctatcgcca cccgctgctt ttggccgccg gacagcttag 2835241 gcggtttgta ggagaccctg tcttttaatc cgactttttc cagcgcttca tatgcccgtt 2835301 gccttctctc ttttttcttc actttattgt agatcatcgg cagctcgaca ttttgcagcg 2835361 cggtgagacg cggcagcaaa tgaaaagttt gaaacacaaa cccgattgat tcattgcgaa 2835421 tttcggctaa agccccgtct ttccctttca atatatcgat ctggtcaagc gtataggttc 2835481 ctgaggttgg cctgtccaaa cagccgataa tattcattaa cgttgacttt ccagaaccgg 2835541 aaggccccat aatagctaaa aactcccccg cctgaacggt cagattgata tgtttcaaga 2835601 ttggaacttc ttcttttccc agcttgtacg acttcgaaat attattcagt gtcagcattg 2835661 actgtaacct gctttccttc cttgaccgcg ggatcaggat agatcacata atcttccggc 2835721 gtcaggccgc tcttaatttc caccatgtca ttttcatcag tctctccgat ttcaacaggc 2835781 tgcttaaccg ctttgtgatt ctcatcagct ttccatacgt acggttcgcc gtcatcctga 2835841 atgaccatgt cggacggcag cttgatcgtg tccgcatcag cattatcact catcacttcg 2835901 atgttgacat gatagccgac ttcaagacct ttatggctgt ctaataaaat ggtgaaagga 2835961 tagttagagg actggggatt catttcttca tcagcaaagc tttctgattc ttcaccctcg 2836021 cctgctcccg ctggaagctt gccgatcgag gtgacctttc ctttccactc gccctcaccg 2836081 cctgttttca gcgtgaccct gactttgctg ccttttttga tcgtgtccat taacagctca 2836141 ttgatttggc ttttgaccag atatttgcct gtcgaaacaa tctggatata cgggcctgct 2836201 gcctggtcgc ctgttgcacc gtcagcgata tcctgattga cgctttgaac gattccgtca 2836261 tgcttgcttg taatgacatt ggaacctttg tttttcgtca ggccagccag ttctttttga 2836321 tgctgcttca gttcaagctg gcttgttttc aaatcgaaat tggtttgatc aagttcatct 2836381 tgaagctggt ttttctcttc ttttcctgca actttcagct ttttttccgt ttccgttatt 2836441 gatttttgca aacggttgat ttgcagattt gtcatttcaa tttgcaaatt ggcttgctcc 2836501 acttcatcag aatgatcctc gccctcatac tcaaaaagct tatcgccctt tttaacctga 2836561 tcgccttctt tgacgtatgt ttttttaatg ctgccttttt ctgaatctat gtatactttc 2836621 tgctgtttct caggttcaac ctttccagaa aacgtttggc ctgattctga atctcctccc 2836681 atgtataccg cgaccgattc agcatagggc tccgatgata cggcaacttg gttcatgtga 2836741 gtaaaaaagt aaaaaccgcc agcgccgatc ccagccaata caagcacacc ggcacatatc 2836801 gcaccgccaa taagccattt tttcttcttg gacacaacga tctcctcttt ctgtaaacta 2836861 tgtaatattt tcgaaacatt ctaaccaata ttatctatta attcaaaaag acttgcaatc 2836921 cttttattga aatgacggaa tcaaatagaa aaattgtatt ttcaaagccg aataaaaaaa 2836981 atcccggctt caaaccggga ttttttcata cagtaactag ctctttttca tttttaatca 2837041 agtcatatgt caagcataca ggtttatttg tacggggatc agtcacgatt tcggcatcaa 2837101 tctgaaatac ctgcttcaaa atgtctggtg tcatgacctc cagagcagtt ccttccttga 2837161 tgaccgtgcc ttttttgagc gcgatcatat aatgagaaaa acgagctgca tggttaagat 2837221 catgaatgac cattaaaatc gtccgccctt gctctttgtt gagtctgtca agcagctgca 2837281 gaatttcaag ctgatgtgca agatcaagat acgttgtagg ttcatccagc agaagcagtt 2837341 ccgtcccttg cgcaagcgcc atggcaatcc acacacgttg acgctgtccg cctgacaatg 2837401 cctcaatcgg ccgttcagca tattcagcca tgcctgtttc ttcaagcgcc catttgataa 2837461 tccggcggtc ttcgtcattt aatctgccga atcctgattg atgcggaaac ctgccgtacg 2837521 acaccaattc gtgcactgtt aggccgctcg gcgcttcagg tgtctgtgga agaatcgcca 2837581 tatcttttgc aatgtccttt gtagacattt tatgaatcgc tttgccgttt aaatagacgg 2837641 cacctgcatg tgaacgcata attctggaca ttgtttttaa aatcgttgat ttcccgcagc 2837701 cgttcgggcc aattaaggtg gtaattttcc ctttaggaat cgatatattt aaatcctcta 2837761 caatcaccct gtcgccataa ccgattccaa gctgttccgt tgataatgaa ttcatattcg 2837821 gccccctcct ctaattcgct ttcatcaata aataaataaa gtaaggcgca cctagcacgg 2837881 aaatgacaag tccgaccgga atttctgatg gtgccaatac atttctcgcc agcgtatcag 2837941 caagcaaaaa caggaatgag ccgatgaagg cggagaccgg tatcagcgtc tggtgacgtg 2838001 gaccggtcag ccttctagcc acatgcggcg cgatcaatcc gagaaacgca atgccccccg 2838061 cagctgccac gcatgaagcg gcaagagtga ccgctgccag aagaagaatc cgtctttcct 2838121 tttcaacagc ggtgcccagc ccggtcgcca attggtctcc gagctgcata atgttcaaat 2838181 agcgtgcctt atataaagta aacagaagca agatcacaat ccaagggaga atcgcccaga 2838241 tcatattcca gttcgccccc catattgagc cggatatcca aaccgcggct tgcataaaat 2838301 catgagggtc catcttgagc tgaaaaatca gcaacagggc gttgaatccg gcattcaccc 2838361 ctatgccgac taaaatcagc cgaatcggtg tcacgccttt tttccatgcc agaatataaa 2838421 tgagaaacgc agcgaggatt gctcctgcca aagcactgaa cggcagcata aatgttccga 2838481 aaaagctaag atctgaagct gacccttgaa aaaagtatat aaaaagcact acagcaagtg 2838541 aaccgccggc gttaattccg agaataccag gctcggcaag ttcattttga gacacgcttt 2838601 gcaaaatggc tccagctacg gagatccctg ctccaacaag caaagaaagg atgatccggg 2838661 gcagcctgaa ctcaaataag acaagttcat cacgcgccgt tccttggccg aaaaagacct 2838721 gaagcgtttt aagcggtgca attttgataa cgcccaaatt gagactgata aaaaagacca 2838781 ccacgataag caaaaaggtc acagccatta caatgagcgg tttgtttgtt tttgttttca 2838841 ttacagccct ctcctttcac gacgtgccaa ataaaagaaa aagggaacgc cgataagaga 2838901 agtcagcgcg ccgacaggcg tttcaaaggg cgcatttacg agtctggccg ctatgtcagc 2838961 aaaaacaagc aaaacagcac cgagcaccgc cgagcaagga atgatccacc gataatccac 2839021 accgaccaaa aaacgggtaa tatgcggaat gatcagcccg ataaatgcaa tggtgccggc 2839081 aatggaaacc gcagctccgg tcagaattac tacaataagc atgccaacca gtttcaccgc 2839141 tgatgtatat tgtccaagcc cttttgccag atcgtcaccg agacttaaca ctgtaacaga 2839201 ccgggcgatg aaaaacgcga gcgttaaacc gacagcccct gcaataagca aaagctggac 2839261 ccccgaccat ttcacacccg ctaccccgcc tgcgtaccaa aagctgatat cctgagcgac 2839321 atcaaagcgg attgcaatgg cagttgaaat gccggtaaag aaataagtaa ctgccgtacc 2839381 cgccagagca agctttacag gcgtaagtcc gccccttgaa aacatgccta tgcccattac 2839441 cgtcgatgcc cccagccccg ctcccgcaaa ggaccatagc acaagcccca ttgcagaaag 2839501 tccgggaaaa aaggcaaacg caatcgaaac cgcaaacgca gagcctgatg tcacacccat 2839561 aatcgaaggc tctgccaaag ggtttctcgt catcccctgc atgattgctc ccgacactgc 2839621 caacaatgcg cctacaagcg cggcagccgc cgttctcgga agccgaagat catgtataat 2839681 ttggtgagat gtctttgtcg gctgataatg aaaaatggcc tcccatacag tgcgcaaatg 2839741 aatatccgct gcacctaggg atatggataa aaatgcgcca aggcaaagca ggcatagacc 2839801 tgcgataagg acgatgaccg cgccatatgt ccttgacgtc cattggattt cttctgatgc 2839861 agtccgtata tttttatgtt gactcaactg ccgtacttcc tttctgttac tgataatgat 2839921 tatcaattgc tgtttcagta tatcactttt ttcagctgat ttaatagagt gttttgaaca 2839981 aaaatgaaaa tgcatttgca aaaatatcgt gtcaaccggc acttgcagtg gtataatcac 2840041 agatgataat gattctcttt ttcatctatc ttttagaaag aaggtatgag atatgaccca 2840101 tatatacaag aaactcggag ccgcgttttt tgccctgtta ttgattgcag cgctggcagc 2840161 ctgcgggaat aactcagaaa gcaaaggttc tgcctctgat tcaaaaggcg cagaaacctt 2840221 tacatacaag gctgaaaacg gaaatgtaaa aatcccgaag catcctaaac gggtggttgt 2840281 catggcagac ggctattacg gctacttcaa aacactcggc atcaacgttg taggtgcgcc 2840341 tgagaatgta tttaaaaacc cttactacaa aggaaaaacc aacggcgtcg aaaacatcgg 2840401 agacggcact tcggttgaaa aggtcattga tttgaaccct gacctgatta tcgtctggac 2840461 aacacagggc gctgatatta aaaagcttga aaaaattgcg ccgactgtcg cagtaaaata 2840521 cgataagctc gacaacatcg aacagctgaa agaatttgca aaaatgacgg gaactgaaga 2840581 taaagctgaa aaatggctgg ccaagtggga taaaaaagtt gcggccgcta aaacaaaaat 2840641 caaaaaagcg gtcggtgaca aaaccatttc cattatgcaa acgaacggaa aagacattta 2840701 cgtatttggt aaagactttg gaagaggcgg aagcatcatt tacaaagacc tcggcctgca 2840761 ggctacaaag ctgacaaaag aaaaagccat tgaccagggg ccaggttata caagtatttc 2840821 attagagaag ctccctgact tcgccggaga ttacattttc gcgggcccat ggcaatcagg 2840881 cggtgatgat ggcggcgttt ttgaaagctc catttggaag aacctgaatg ccgttaaaaa 2840941 tggccatgta tacaagatgg atccgatcgg attctatttc acagacccga tttcattaga 2841001 aggacaactg gagtttatta cggaaagctt gactaaataa acaaaagagc cgcctgcccg 2841061 cggctctttt gcttatttat aaggaacggc tcaatttgaa tcatatcgga tattttcttt 2841121 gagccattca tattaagctg catcctcatc acgatcagtt tttttatgct ggagagactg 2841181 aaaaacgttt tttgcatatt taacgaacgg attcctaaca ggagaaattg tgattttata 2841241 aaaaagacac ctgagcaaat caggtgtctt ttcattatgc ttgtttttct ttctggaact 2841301 tgttactcac aaatggataa acgattaagc cgacaaagaa taaaccgatg ccgagtataa 2841361 atgtcgttaa atctgctgtg cctgttacga taacaaacac ggagtatgca cacgccagta 2841421 tcgcgatcaa tccgtctctt acacgggagc ctttcagctg gtcatacgtt tcacctttga 2841481 tgactacctt caagctgtag attgcagata ccagatacgg aattaaatat gcgagtgtag 2841541 ccgctgtcgt taaaaatgta aatgcgtcac ttattgtccg ggaaataacc gagaaaatga 2841601 agacctgtga catgacgttt gtaataatga gtgcaatgac cggacttccc tttttattcg 2841661 tttttgcaaa aaatgccggg aaatctcctg ctttagcggc ttggtatggc acctcagagc 2841721 caagcaaaat ccagccgagc atcgttccga ataaacaaag gatagccaaa agcgccataa 2841781 tcacgcttcc cgcgtttcca acaatcgcat agagtacatc aacaaatggt ttttcagagc 2841841 cgacaagctt atcatgcggc agaacaccca tcgtaattaa agtcacaata atatatatgc 2841901 tcaaggcaat cagcaagccg gtaattgtcg cacgtttcac atcacgctga gagcgcgcac 2841961 ggccggacag gatcaccgcg gattcaattc cgacaaacgc ccacagtgta gaaatcgcag 2842021 cgttatgaac ctggccacca attccaatgc ttgtgccgtt ttctccttga accgggaaat 2842081 aaaaatgacc gaataatgac gtttgaaaca caaacaaacc ggcaacgata aagaagacaa 2842141 aacctaatac tttagaaagc gttgtgacaa agtttaattt acttgcgccg ttaatgctgg 2842201 caacaagaat cgcgtgcgtt ccccataaca agatcgtaca tacggcaaac gtcagtaatt 2842261 ggccgagtgt cacctcttgc ccgccgatcg aaaacatctc acgtttatca accaagatcg 2842321 ggaagaacga agtcaagtaa ccggcgagac ttgtgatgat cgccacgtta ctgatccagc 2842381 tcgccaccca gtagccccac accattgtga aaccggcagc gttgcctttt ttcgggtcag 2842441 aaaacagcgc tcttgcataa ctttgcggtc ccgctgtcag ttcaggcttg cgaatggaca 2842501 agtgtccgaa cacaagtgca atcatcagca cgccggcacc tgtcaaaagc caggcggacg 2842561 tagctccaaa cggactcgca attgaagcaa gcgagctcgg caaggagaaa attcctgatc 2842621 caaccatatt tccaacgaca aacgccgtta ataaccaaaa accccatttt tttgtctgtt 2842681 ccattccagt acctccatga ttctttgtac ggaccagacc ccgagatcat ataaacgcaa 2842741 aaaaagcctg aacaaaagtc catgcttaaa gaaacacaca cccttgatct ccggatagcc 2842801 ctccgcgaaa aagcacgcgg cagtcctgca cttattcaga tacagtccca gcatagagaa 2842861 ggatcggctt tctccacact tcggcgctga tgccttttac acatgtttaa cagcccctgt 2842921 cagcctagca tgtgtgactc atcatccgcg caacctctac ctcactgaga aagagtgagg 2842981 atttaattat tcagttactc ccagaaggtt atcaaagaaa ggatgatctg tcaaagggaa 2843041 cagatggaaa atacggatag agccaagccc tatccgcatg tggttatcga ttatttttct 2843101 ttttttgcac agcttcttga agcggatcat cttttagagc tgaaccagca tcttcaagag 2843161 ctccttggat tacgtttttt tctttttcgg aacgttttcc tttatcttta ttaaagaaac 2843221 ccattcgtat cacctctttt aaaaaatagg tacatgttta agatgccttt ttcctgaaaa 2843281 attatgcggg atatttttta tcgtccaaag tcctgttgat caaacataca ttctcttgat 2843341 atatttgtaa ttcagagatt ttttgcaaaa gataaaagga gaagcggcaa atgacaggaa 2843401 aaacacacat catgggaggc atcgcttctt gtacggcagc ggcttattat tatggatttg 2843461 atccagtgct tatggctgcg tcaggcgcgg ttggagcatt aatacccgat atctgccaca 2843521 cacaaagcaa aatcgggaga aaatttccta ttttatcgaa agtggtcagc tccgtttttg 2843581 gccatcgcac ctttacacac agcctgctgt ttatgctcat catgtttttt atcacttcta 2843641 catacattcc agataaaaac atatcagccg gcctgatgat cggaatggcg agccacttga 2843701 ttcttgacgc ttggacggtg aacggaatca aattattatt cccttccacg atccgcgttc 2843761 ggcttccatt atatatgaag acaggcagtt tttctgagca gctcgtgcta gccggcctga 2843821 cccttgcttc atgttactac ttttatatgc tgtttcatgg ccgcatgttt taaacatgag 2843881 tgctgagact tgtctgaacc ggctgttttt agtaggtttt acttaagaag catttcatgc 2843941 agatgatcaa gaaaacgtga ggagtcatat tgatgaaagg aacctttttt cacaatcagc 2844001 ggtttttatg tttttcgatc ttatttatgt ggatcaaaac gtatgtgata tataaactcg 2844061 gctttgattt gcaaatcgat actctgttgg aggagctaat gctgctggtc aacccgctca 2844121 gctttattct tcctttattc gggatcggcc tgtttctaaa agaaaacaag cagcgggcct 2844181 ttttgctgat tgccaatttg gttctgactg ttatcttgat ctctaatacg attttttacg 2844241 gcttttatat cgattttatt accatcccgg ttttatttca ggccagcaac atgagcgata 2844301 tgggcagcag tgtaaaagaa ctgttccatc ctctgtttat cgccctgttt gtggatttgg 2844361 tttttctgct gttgttcgcc agaaaaacca aacacccaca gacaaaagcc gctccccaca 2844421 cgatcaaacg gtactatgca gcttcctgcg gaatgctttt atgcacactg gcacttgcag 2844481 aagtacagca gccgaagctt ttggcacatt cttttgaccg ggaaatgcta gtcaaaagca 2844541 tcggcctgtt tcagttccat atttacgata caatttctca gactgttaat atcagcgcga 2844601 aagcttttgc cgatgaagac agtataactg ccattaaaaa ctacacagag gctgattaca 2844661 gcaagcctga tcaaagcaaa ttcggtcttg caaaggggcg caatgtcatc tttgtaacac 2844721 ttgagtcgac ccaaagcttt gttctgaatg aaaaagtaaa tggaaaagaa attaccccat 2844781 ttatgaatga tctcataaaa aaaagctatt cctttgatca tttctatcag caaacagaac 2844841 aaggcaaaac atcagattca gaatttatcg tcgctaactc actgtatccc tcccttagcg 2844901 gcgccgtctt tttcacgaaa agcgaccatc aatttcatac gatgtataaa tcgctgaagc 2844961 agcacgatta ttattcagcc gtctttcacg ctaaccataa aacattttgg aacagagatg 2845021 tcatgtacga tacatttggc attgaccgct tttttgatgt tgatgatttt catgtcactc 2845081 ccgggacatc gacaagctgg ggcttaaaag acaaagaatt tttagagcag tccgccaaaa 2845141 agctgaaaag cctaccgcag ccgttctaca gcagttttat cacgttaacg aatcattttc 2845201 cgtttgagat tgatgaaaag gatcagctga tagatgaatt cgattcaagc agtgatctgt 2845261 taaaccgcta tgtgaccacg gttcgctatg aggatgaagc attgaagcat tttatcaaaa 2845321 aactgaagga cgaaggctta tacgaaaatt cgatgatcgt atttatggga gatcattacg 2845381 gcatttctga agcccataac gaggcaatgg ctgagttttt agggaaagac gaaatcacac 2845441 cgtatgacaa cgttcagctc cagcgggtgc cgtttatcat acatatcccg ggaatcaccg 2845501 atcaacagcc ggaaaccatc cctgatgccg ggggacaggt cgacgtcagg ccgacgctga 2845561 tgcatttgct cggcgttgag acaaaaggcg atatccaatt cggcaatgat ttgctgtcgg 2845621 gcgaccgcac cccattcgcc gttctgcgaa acggcagctt tattacgaac gattatgtat 2845681 acacaaagaa cacgtgctat agccaaaaaa caggtgaagt gctggaagat caggatgcgt 2845741 gcctccctta caaggagaaa gcaaacgaag aactgtctct ctctgataaa attttaaatg 2845801 gtgacctgct caggttttcc gaatgaaaaa atccctctat caagagggat tttttacgtt 2845861 tccaatatca ccttgccagt cagcttcgtt tcatagccgt ttaaatgaga cagattcgcc 2845921 ttgtagtcct cagaattcaa aatctccttc acggctttga gcaactgctc attttttttc 2845981 aaaacaacga tatcatattg ttcgtcgatg agcgggataa aatcaacact gcccatatgt 2846041 gccgcgtgct gtgccccgat tcccgcgtca gcctgtccgc ttgaaacttg tgaagcggca 2846101 gcgtaatgat cagtcacgat atcgccatat cccactacat cagccggatt cacaccaagc 2846161 aagccaagct gttcatcaag gagcaccctt gcgccagaac ccttttccct gttgatgatc 2846221 cggatatcgg ctcttttcaa gtctttccag ccttgaatgt ttttcggatt ccctttttgc 2846281 acatacagtc ctgctttgcg gagaacgaca ttgatgagac aaaacggttc acctgtcaaa 2846341 atccgtttta cataaggcgc gttatactgg cccgtttctg catcgtacaa atggaggctg 2846401 acaatgtcac acttgccttg atacatatca atcaggctgt ttaagcttcc tttgtattta 2846461 cggagcggcg tctcctgaat ggcattctcc aaatgcttgc tgaggatatc catcgaaatg 2846521 tcctgtccgc tgatcatgac atttggtctg ccgtccggct cagcctcctg cacctgtttc 2846581 ggcgcttctt ttgcagcgat gggctgagac attctcatat tcgttttata ttgctttaaa 2846641 tcttcttcat ccacacgcat ctgccttccg acacggtaag caggcagcac gcctttttta 2846701 atcaagtcat aaacggtcag ctttgatacc ttcagcagac ctgcaacttc ttctatcgta 2846761 taggaagagg tttcattcat catcatcact ctcctatttt attatacctt ttcgccgaat 2846821 gtaaaaaaac ccacataaac caaacataat cagttataat tagttatatc taatgataag 2846881 gggtgcaatc atgtttaaga agtattctat tttcatcgca gccttaactg cttttctgct 2846941 tgtagcaggc tgttcttcaa accagtcttc aacggacagc gagaaaaaag taacgttaac 2847001 catctcagct gccgccagcg cgcaggatgc acttgaggaa atccaaaaaa attatgaaaa 2847061 agatcatcaa catataacca tccaagataa ctatggctca tccggcgcct tgcaaaaaca 2847121 gatttctcaa ggagcaggag cagatctgtt cttctcagct gctgaggata aatttaaaaa 2847181 gctggtggat gatggagata tcgcaaaaaa agacagcact gaattagtcg gtaatgaaat 2847241 tgtgctggtc gtaccgaaaa acggagattc acctgtgaca agcttcagca atctggctga 2847301 atcagaaaaa atcgctcttg gcactccgga atccgtaccg gcaggagctt atgggaaaga 2847361 atcactgaca aagctgtctt tatgggacaa agtgaaggat aaaattgtgt atggaaaaga 2847421 cgttcgccaa gttctttctt atgttgaaac cggcaatgta gacgcaggtg ttgtttataa 2847481 aacagatgcc ctagtctcga aaaaggtcaa cattgttgac gaggcaaaag cagatacaca 2847541 cagcccaatt gtctatccgt taggaatcgt aaaagataca aaacaccgta aggaagcgaa 2847601 ggaattttac gaatacctgc aatctgatga agcaatgaaa gtatttgaga aatatggctt 2847661 tactgccgag tagcataagc gcttcagaat ttttcacacc cgttgtgctt tcctttcagg 2847721 tggcggcagt tgccggaatt gttgtcatta ttctcggaac acttgctgga gcatggatgt 2847781 cacgggcatc atttttcgga aaaacggcac tcgaaacatg ttttatgctt ccgctcgttc 2847841 ttccgcctac tgttgtcggt tttattctga tcgtcatttt cggaaagcac agcttcatcg 2847901 gacaagccat cgagtggatt ttccagcagc ctgtcatttt cacctggtgg gccgctgtga 2847961 tcgcctcggc tgttgtagcc tttccgctta tgtatcaatc agccaaaacc ggatttgctg 2848021 acattgatcc cgatatacaa ggtgcggcaa tggtagacgg cgctagcaga tggaaagtgt 2848081 ttatccatat ctccgtcccg cttgcctatc cttcgttact gaccggaagc atccttagcc 2848141 ttgcgcgggc gctcggagaa tttggcgcaa cactcatgtt tgcaggaaac atccccggtg 2848201 ttacgcaaac actgccgacg gcgatatatg tcgcattgga ttccggcaac aatacccttg 2848261 cttgggcgtg ggtcgtctgt attgttgtca tttccttttt gatgctgttt ttcattcaac 2848321 agaaaaaaac gcactaaaaa aactccccat aacggggagt tttttgatta aaacagaagc 2848381 tcatcaggat ttggaccgac acgctcatct ttatttaatg cgtcaatttt gtccatgtct 2848441 tcttgagaca attcgaaatc aaaaatatca gcgttttcga tgatacggtg ttctttaatg 2848501 gattttggaa tggttacaac tccatgctgc agatcccagc gcaaaatcac ttgagccaca 2848561 gatttattgt gtttttcagc aatctgtgtc agtacttcgt tatccaaaag ctgtccctgc 2848621 atgagcggag accacgcttc cagctgaatg ccttgccctt tgcagtaatc tcttaattct 2848681 ttttgcgtca agcgagggtg aaattcaact tggttcacca tcggtttgat ttcagcatct 2848741 ttcaacagct cttctaaatg atgaacttgg aaattgctga cgccgatcgc gcgaattttg 2848801 ccgtctttgt acagcttttc aagcgcgcgc catgtatctt tatatttatc tttgccaggc 2848861 caatggatca aatataaatc taagtaatca agctgcagtc tttctaggct tttttcaaag 2848921 gcagcaagcg ttgtttcata gccttgatct tcattccaca cttttgatgt gatgaagagc 2848981 tcttctcttg ccacaccgga ttctttaatc ccgatgccaa cgccttcttc atttttgtag 2849041 atcgctgctg tatcaatact gcgatagcca tttttaattg ccgctttcac tgattcagtc 2849101 gcttcattac cattttctac tttaaaaacg cccagaccga accaaggcat ttcaactccg 2849161 ttatgtaact ttacagtatc ttttaaactt gttggcactt gaacctccac cctttcactg 2849221 aaatgtaagc gtctatatta tctcacattc ctctcagccg ataccaataa tacgcttaag 2849281 accctctttt tgcttctttt ttcacagcac aggcaaatcc aaacactatt tttttcctat 2849341 tttaacaata ttgagattac aaatacattg agcagggtat gcgtgtagtg taaccaaatg 2849401 aaaacaaagg aggaaacaac ttgaaacgta ttcgtatccc aatgacactt gctcttggtg 2849461 ccgctttgac aattgcccct ttgtcctttg cttccgctga agaaaatcct gctccgaaga 2849521 tgtcgcagac aactactgct ggaacaactg ccgctgatgt aggtttaaac gtcaacctgg 2849581 atgtacttgg aattgccaac cagatcgctg atgccatcaa atccgcacag aatagggatg 2849641 gctttgtgaa aaacctcatg gagtcttcct tctacgcgtc cggccaaaaa tataacgtca 2849701 tggtctttaa tttaagccag gaatatgaag atcatttgaa cggtgtgcaa ttttacggct 2849761 cagccgttta cgacggcatt acgtatggca tttgggtatt tgaagatgga acctttacaa 2849821 acaaaggcga tggcggctgg atcaactggg ccttcagagg ctggttcgac cgggatggca 2849881 gcactgtcgc atttcatcgc ccttaatata aaaaaagctg gcgctctaac gccagctttt 2849941 tttctgcatt tattcgccgc cttcaagcat ggcggcttcg acatcattaa tgtattggcg 2850001 aagctcatgg gagatgtccc gggaaatttc cctctcttcg aagagcgttt gaatttcatt 2850061 tctgatcgcc tgcacagcct tcagcttcac ttccagcttc tgattttcaa aatgggcact 2850121 tgattttaac tcatgatggc tgtgctccag cctgaaaatt aactgcttat agaatgtaat 2850181 gacagataaa aacacttctt tatgctcatc cgtcttatgt ttttccagat attctatcgc 2850241 tgcttttgcc gttttcactc ttgttgcccg tatcaatccc gcttcattta aaatcgacat 2850301 ctccggcttt ttatgttcac cgaagaaaat ccaatacatc agcctcttga gccttgtttt 2850361 tgataacccg actttaaacg ggttggcata caaaatttcc aactcgttaa atcgttcttg 2850421 cagcacattt gctgtttctt ccgggatgtc tccccgctcc agcattttca tcagcgcctc 2850481 ttgctcagcc ttaaccccct gcgcacggac ttttcgctcg tgcttcttaa tgcgattaga 2850541 tgatgtatac tgctgaaaac gaagattttt cattttctca ttgtattcag ctatcaccgc 2850601 aagagaggcc gttttgtttg tctcattcat gtcctcttta atcgtttgaa gggctgtttt 2850661 gatcaacttg cgtctcgccg tcagcagctt cttatttcgt tcctcgtcct cttcttcttt 2850721 ttcagtcaga attggcagca caacggtggc aatgacaagc gtgcataaaa tgacgccggc 2850781 tgctaaaaag agaatcagat ttctttccgg aaacggcgta ccgtcctcca ggaaatacgg 2850841 aatggaaaaa gaacctgcaa gcgttactgc tccacgcaca ccggaaatcg aaattaacag 2850901 cgtcgaacga agacccggtt tatagatgtt ctgatcttta ttaaagaacc atttgccgtt 2850961 ccagaagaac agcacccaca ggaatctaag gagcattaat gtaaatgtga tgactaggat 2851021 atagccgatc accttcatgt tgctgatggc agtgtcgtta aagataacag aaataacatc 2851081 agggatttgc gtgccgagaa taacgaagac caggccgttc aaaataaata aaataatgtt 2851141 ccacgtactt gaggagacga tttgcagctt gatcatcgtt gattccagac gatcctgttc 2851201 aaccgcatgg gtaataccgc cagctacaac agctaaaatg cccgaaacgc cgatttcttc 2851261 agctgccaaa taaatcacaa acggcgtcag aatttgaatc agcatatgca tcgtgacatc 2851321 ctgcatgcca aggcggcgca gaaataggcg aaaacgaata atcaaaaatg aaatgacaac 2851381 cccgcacagc aagcctccga gagaaataaa gacaaagctg acagccgctt gtgctaatga 2851441 aaatgcacca gtcactgccg ctgcaatcgc aaacttaaag gccaccagac ctgatgcatc 2851501 attcatcagc ccctcacctt ccagcaggcg aagaatccct tttggcattt tcactcttcc 2851561 tgataatgcg ctgacagcga cgacatcagt cggtgaaaga atggccgcaa gtccaaaggc 2851621 cgctgccagc ggaatagcag gaatcatcca gtgaatcgtg tagccgccta caatcacagt 2851681 cgcaaataca aggccgagtg caagcaataa aatcggagcc cttaaattcc aaagctctgc 2851741 ccgcggtgtc ctctttccat cattaaatag cagaggcgcg ataaaaagaa caaaaaacaa 2851801 ttcggtgttt aattcaaaat gaagtccctg tggaaatgag gcggcaagaa tcccaagagc 2851861 cacttgaatc agcggcaccg gaataaacgg aataaaccgg ttcacgatat tagaaatcgc 2851921 aataatcgtt aataatacga gcacaactaa aaatatgtcc aaatgcatga cctccttcgt 2851981 ctgttgtgtg tcggcatgat gagccaaaaa atctgtttgt ctaaaagccc ttgagctagg 2852041 gtggccttgc atccgctatg tggtttcgca ggagttctct ccacacttgt cttcttttat 2852101 agtacccttt ttagggtatt ttttctcatg atatgctcac agtgaacttt tttgcagaag 2852161 agcaaattat agaaaaaaga gacaggaagc tactccctgt ctctcgtctt tctttctcaa 2852221 tcatgaaaat tcgtaccgtc agttgttgct ttaataatgc ccgcgcgaat gacaaagtca 2852281 ccgaaatgct cgccttcctc gcgttctttc gcatagcggg aaagaaggat gcgcagctcg 2852341 cttaaaatgt ctgcttcacc gatgttttca cggtacattt tgcttaaacg gcttccgtca 2852401 aacgcagcgc caagatacat attatatttg cccggcgcct ttccgataaa tccgatctca 2852461 ccgagtgcat gacgtgcaca gccgttcggg catcctgtca tgcgaatggt gatttcctga 2852521 tcacgaaggc cgttttcgtc aataatctct tcaatcttat ctaacagggt cggcaaataa 2852581 cgttctgctt cagccattgc caatccgcag gtcggaagag cgacgcacgc catcgagctg 2852641 cggcgaagcg ctgaatagtg cttgccgtca gttagtccgt actgttcaat taaagcactg 2852701 atttcttctt ttttatcgct tgaaacgttc gcaatcatta agttctgatt ggctgtcagc 2852761 cggaactcac ctgtatgaac tttggcgatt tcccgcaagc cagtcatcag cttataatca 2852821 tcgtaatccg ttatacggcc gccttcgaca aacagcgtga aatgccattt atcctcgatg 2852881 ccttccaccc agccatagcg gtcgccgtta tgatcgaaat gatacggctt cgcttcttcc 2852941 aggctccagc cgagacggtt ttccaattct tcttttacgt tttctaaacc gaggcggtca 2853001 actgtgtatt tgaaccgcgc atttttacgg acagaacggt tgccgtaatc acgctgaatc 2853061 gtaatcgttt tttcagcaac gtcatacatt tgctcaggcc ggcagaaacc gatcaccttg 2853121 gctaattgcg gatatgtcgc agtatcgcca tgcgtcattc ccataccgcc gccgattgcc 2853181 acgttaaaac cgatcagctt gccatcctcg acaatcgcaa tgaatccgag atcttgtgaa 2853241 aagacgtcaa tatcattaga cggcggaacg gcaataccga ttttaaactt ccgcggcaga 2853301 tagagcggtc cgtacattgg ctcgacttct tcctccggcg tgccggcaac tctttcctca 2853361 tcaagccaaa tttcatgata tgctctcgtc cgcggcagca gatcatcact taatttttta 2853421 gaccactcgt atacctctga gtggatttca gattgataag ggtttgatgc acacatgacg 2853481 ttacggttta cgtctccgca ggctgcgatc gtatccaaaa gtgctgagtg gatcgtctga 2853541 atggttttct tcatgttcca tttcagaatt ccgtgcattt ggaatgtttc acgtgtcgtc 2853601 aattttaatg tgccgttccc gtatttctgg gacaggtcat ccatgacaag ccattgttca 2853661 ggcgtcgaga cgccccctgg catacgcacg cgcagcatga actgatatgc gggctcaagc 2853721 ttctgctttt ggcgttcatt tcggaggtcg cggtcatcct gcaaataact gccgtggtgt 2853781 ttcatcaggc ggttatcatc atccggaatt cccgcactga ttcgatcgag catcacttct 2853841 ttcagcgtgc cgcgcaaata atcactttct tttttaatgc gttcaacatc acttggagag 2853901 ccgtccggtg cttttagaat tttggtcacc atgttgaaaa actcctttca agtcaaatca 2853961 atatacatca cgctgatagc gtttttgctg ctgcatatcg gcaagataag cctccgcctc 2854021 ttcgcggctc atattgcctt ctttttcgat aatttcaagc aatgtgttat ggacgtcatg 2854081 cgccatgtgc ttttcatctc cgcaaatgta aacagccgct ccttcttgaa gccattcaaa 2854141 caattctgcg ctatgttcaa gcatgcggtg ctgcacatat actttttctt ccgtatcacg 2854201 tgagaacgcc acatccattt ttgtcagcac accgtctttg agccaattct gccactctgt 2854261 ctggtaaagg aaatccgtga caaagtgctg atcgccaaag aacatccatg cctttccttc 2854321 cgctcccgtc tcctcacgct cctgcataaa cgaacggaaa ggtgcgacgc ctgtcccagg 2854381 gcccaccatg ataatcggtg tttcagggtc tttcggaagc ttaaagtttt gattgtgctg 2854441 tacataaacc ggcagtgtgt ctcccggctg cagtcgttcc gcgcacaaaa tcgagcagac 2854501 gccttttcgt tcacggccgt gcgcatcgta gcggactgcg ccgattgtta agtgcacttc 2854561 atccggattt gcggataaac tgcttgcaat cgaataaagg cgggcaggca tttttcgcaa 2854621 aatcgagaca aactcctgcg cagatacact aaatgggcca tagtcacgga cgagatcaag 2854681 caaatcgcgc ccttcaatat aggcttttac attctcctca tttcccgggg ctaaaagctc 2854741 tctaagctca tcgttccctg tcagctgggc tgcctgttca agaagcggtt ttgtgagaac 2854801 ggtaatctca tagtgagaaa tcagcgcttc tttcagcggt cggacatcac cttgcttatt 2854861 aagcgtcaca atttcttccg ggtcccaatt catttcctta aggagcagct cgacaagttc 2854921 cggatcgttt tccggataga cgccgaggct gtcaccaggc tcgtaagtca ggccagatcc 2854981 ttcaagagac agctccacat ggcgtgtttc tttatttgat cctctgccgt ttaaatttaa 2855041 attttctaac acttcagccc gaaacgggtt tgttctggaa tacgaagact caccggtttg 2855101 tgacgcagcc gccggcgcag gcgcggcgct tccgccccca gcttcattta atcctttcaa 2855161 tacaccctca agccattcgg ctgccggttc atcatagtca agatcgcaat caacgcgcgg 2855221 agaaatccgt tttccgccga gttcttctaa gcgttgatca aattctttcc ctgtctggca 2855281 gaaaaattcg tacgaactgt caccaagcgc caaaacggaa aagcgcaggt cttcaagctt 2855341 aggcgcccgt cttccgtgca gaaattcatg aaacgacagc gcgttatcag gcggctcgcc 2855401 ttctccatgc gtactgacga cgattaaaag attggttacc ttcttcagct gattcggctt 2855461 aaaatcgctc atggatgaga cggtcacttg aaaaccgctc tgttcaagct gcttgccggc 2855521 attttctgca agcccctgtg cgtttcccgt ctgtgaacca taaagaacgg tcacttcttt 2855581 tgaaacggcc ggtgccggtg cttccgctga cacagctgcc gccggcgtac ccgcagcttc 2855641 ttgggcggaa acagattgag cggataaata tccgctcagc cagattttct gggattcggt 2855701 caaggtcggc agaaggcggt taaggagctc tgcctgctcc tgattaaacg gactgttcat 2855761 tacctgaagt tgcaacgtat ccacctcaca aagttataaa ctgatcgaaa attgcatcta 2855821 attgaacttt accggaatac taggcttaag taaaatatat ttacatgatg ataactatta 2855881 agaatcctaa tgataaaacg gctatgcttc atgtaaatag aaaaaagaga aggactccct 2855941 tctcttcatt cagcaatctg atataagtga ggcggcacag cggttacaaa cggactggct 2856001 tcacctgtat aaaataccgc cagcatgtgc atcgcacggg tgcacgcagt atataaaagc 2856061 ctgcggtcgt gctctgtatg atagtgttct tcagatgcat catagacaag cactgcgtca 2856121 aattcaattc ccttcgctaa atacaccgga atcacgcaaa cacccttttg aaatggttga 2856181 ttttctttat gaatcaggcg aacatctgta tattcactca tgtgggcgtg cgcctgtatg 2856241 cattgatgcg cagtcttgca gatgacggct attgtttcgt gccctttttt cttgagccgg 2856301 ccaatttctt gcgcgagctt ttggcaaagg ctctcatgtc cttcagtttt gacaacgagc 2856361 ggcatttccc cgcttctatt aaacggctca atatccgctc catcttgaag catcgctttg 2856421 gtaaactcga caatctgcct tgttgatctg tatgttctct ttaaacgaac atactcagca 2856481 ggctcatcct caaagcacgc atccatacgc tgatccccgt ttatggtatg cgcgtagatg 2856541 gactgattga tatcaccgag cactgtcatg ctggcagccg gaaaaatgct tctcatgtaa 2856601 gccatctgaa acggtgaata gtcctgggct tcgtcaataa atagatgttt gattttcgta 2856661 tttttctttc tgccctcaat cagatcctgc atataaagaa acggtgccgc gtcctcatag 2856721 agcaatttat tatccgtaaa tgccgaacgg gtcagctcac ctatcgcatc catcttctca 2856781 tgttgaaatt ttcctcccca gccagaaaac aattgcaaat aaagttgtgt aacatcaaga 2856841 aatgcaagga gcctgactgc ctgtttgagc ggtttgaaag cttttttcac aatgatggcg 2856901 gcaagcagct gctgctctct ttgataatcg ttaaacgtac tctcgctgaa ccgtttcctt 2856961 tcctgcagtt ttttgtacac gtccaagtag tcctctttgt caagcagctc agcttcatga 2857021 acaacccaat cctttcgccg ttcctttttc tcaagcttgt taagctcact cagcagccac 2857081 ttcgcggttt gctccatccg attcggaatg gagtgatttt gatccaatga gtaaaaatag 2857141 gattgaattt gctcctttgt gatcagcttt tgtccgcgga atataatatt tttaaaaatc 2857201 atcccttcag aggaaagccg tgtgacgtat tcattaatga attgctgaaa ggataaaccc 2857261 gccttccatg tgattcctgc aagccttgtt ggaaaatcgc ctccctttgt ttcggtcagg 2857321 caatattcga gctgatcaaa ggggctttca catttgaact tgcggccaag acgatgctcg 2857381 atatattcct gaaacgtcgc ctgctccata ttctcttctc ctaactccgg caaaacagag 2857441 gagacatagc tgttaaataa gaagttgggt gaaaacaaaa cgatttgtcc ggcatcaatg 2857501 acaccgcggt gcctgtataa caaataagcg acacgctgaa gcgcagccga tgttttcccg 2857561 ctgccagccg ctccctgcac gatcaggatc ttgctttttt cattacggat aatctgattt 2857621 tgttctttct gaatcgtaga cacgatgttt ttcatttggg tatcagagtg atggcttaat 2857681 acctcttgca gcatttcatc gccaatcgtc atatcggtat taaacatcgc cttgagagtg 2857741 ccgtttttga tcataaactg gcgtttcagc accatttccc cttctatcgt ttcaccgggc 2857801 acctcgtact ccgcttttcc tggggaataa ttgtagtaca aacttgatat cggcgccctc 2857861 cagtcataga tcagaaagtg ttcctccttc tcatccaaac aggaagctaa accgatataa 2857921 attcgctctg cctgctcctc gccgttttca ataaaatcaa tccggccgaa ataaggcgat 2857981 tttttcaatt gatgaattcg tttgagctgc tgatccatgc gccgatgatt gtgttcccga 2858041 tcagacagca gctctgcctg ctgcttaatg ctagccatcg tttcaatcgc ttcatgggca 2858101 tcatcaaaat taaccttaac atcctcccaa aagctttttc ttaatccgat gatatcatgc 2858161 ttcaacccgc ccgcagacgt ttccagaaac cgctcttttt tttcgagctc cttcagcacc 2858221 tcatctattc tcgactgctc ttccttccat tccttatcct gctgattcat gaacggcacc 2858281 tccagaaaat agttgacaaa catagatgaa atactgtaaa atataattgg atacatatat 2858341 taaatatatg atgcaaactg gcaaatacaa tttataatag cacattcacc caataccaat 2858401 caaggtttgg gttatttata ttatgcagaa aaaaaccgat ttcacttcga aatcggtttt 2858461 tttgctatta attatctaag cgaaaagaac ggtttggcag cttccaatta aacatatagg 2858521 aacaaacccg gcaaacaacg agcacgaaaa acagaacgta taagccgaac gagttcccca 2858581 gccagcccaa gccgacgatt aaaccgccga gcgccgccca taccgcatag atttccgctt 2858641 tcagcacaag cggtttgcgc ccggcaagaa ggtcgcggat gatcccgccc ccgcttcccg 2858701 tcagcaccgc agccacgatc acggcactaa gcggatggcc cattttgacg gcatacagtg 2858761 cgccttggat agcaaaggca gcgaggccga tcgcatctga taaattgccc cacttattcc 2858821 aatgcttcag cagcagcttc ggaaacagaa acacaattgt aatagataaa agcgcgattt 2858881 gaaagtacgc tccctgctcc catagcgctg acaccggaac accgatcagc aaattgcgga 2858941 tcgctcctcc tccaaaagct gtgacaatcc ctaatatata aactcctaaa atatcatatt 2859001 cctcttccat cgcaacaatt gcgccgctga ctgcaaacgc aatgatgcca atcacactaa 2859061 gcagctccca agccattctg atgactccct tttatgtttg ttaaattttc tgacgacctc 2859121 tagattttat aatcgctcca gcgtaaaatc aataacattt tcatgagaaa aaaagataaa 2859181 tttagaggga atacggctat tgctgatgga catgagtttg cgaaattaaa aaagcgcccg 2859241 gcatacgcgg gcgctttttt tgttattcag atttttcgcc tttcagcagg cacataaaaa 2859301 tgataatcag gataaaagca atcagggcca ggaatggaat cgtaataaaa ccaaaccagt 2859361 taatatattg gcccgagcac ggcacgccgc tgacacatgg cttaatgccg ctaaagccgg 2859421 gcactttttg ctctaagtaa tgcatgatcg aaatgaatgc cccaataatc gccatcggga 2859481 gcacatattt tttcactcgt gtgtcccctt gaaaggtggc gatgcctaaa atcaggacga 2859541 gcggatacat gaggatacgc tggtaccagc acagttcaca tggaataaac tttctgattt 2859601 cactgaaata caggctgccc agcatagcga taagagccac aacccaggaa gcatataaaa 2859661 atacgattct atttttcata ttgttacttc cctttcagct ctttttctat tgtctctttg 2859721 atttcatcat aatccgcaaa atttttgatc actttatcat tgacgtaaat cgtcggtgtt 2859781 gcctgtatgt tcattttttg attaaggtca gaatcctttt ccacttgaga agcgaatgtt 2859841 tccttatcaa gattttcctt gagcgtctca ggttttatct ttgtggtgct ttttgcaaga 2859901 tcaccaagga ggcctggggt tacccattcc tgttccgtat ccggctgttt ttcgaacagc 2859961 ttttcatgga aatcccagaa agagtcaggg tcttccttcc atacttcttc agatgcaaga 2860021 gccgctaacc ttgaaccttt tccatggaac atgacgttca cgaaagaaaa tttcacatcg 2860081 cccttatcaa taaagtcttt ttgtattttt ggaaagatgt cactgttaaa caccttgcaa 2860141 gacggacatt tgtaatctcc gaattctact acagttaccg gtgcatcgtc cttgccaagc 2860201 acaggctgcc ctttgataga cggctgtccg gacaccgcat cattgccttg ttccgttttg 2860261 ttattaatga tgacaatggc tgctagcaat acaacaacca caaccgtaag gatgaccgcg 2860321 aatttcgcag aagactgctg tttctttttc actccgacac ctcatcgttt taaaattaaa 2860381 aaagaagcgg atcgcaattg acccacttct ttattttaac aagacaagcg ctgataagaa 2860441 aaccccgaaa aaatgaattc tctccgacaa tttatttgtt tttgagacgc atgacgcgca 2860501 tggcgttcgc cacagcaagc agtgtaacgc cgacatctga gaaaaccgct tcccacatgg 2860561 tcgcaattcc aaatgcacca agaatgagaa agatcgcttt cacacctaaa gcaaagccga 2860621 tgttttgcca cacgattcgc cgtgtccgtt tcgcaatccg aatcgcttct gctatttttg 2860681 acggctgatc tgtcatcagc acgatgtctg cggcttctac cgcggcgtct gagccaaggc 2860741 ctcccatcgc aacccctata tctgcgcgtg caagcaccgg cgtatcattg atgccgtcac 2860801 cgacaaaaat gagtttttca ctaggcaaaa gcttagcttc taatgcttcg acctgcgcga 2860861 ctttatcttg cggcagcagc tctgcatata cctcaccaat cccaagctgt tttccgacgg 2860921 cttctcccgt ttgtttcgaa tcacccgtca gcatagctgt ctgtttgatc ccaagcgact 2860981 tcagatcagc aaccgcctgt gctgcgtctt cctttatctc atccgctatg atgattgctc 2861041 cggcatagcg ttgatctaca gcaacgtgta cgattgttcc agcattttca tccgggacat 2861101 cctcaatttg ttctctttcc atgagctttt tattcccagc aaggatctca gttccattta 2861161 cctttgcaaa aatgccgtga ccggagattt cttcgtatga ctcaatctca tcggaggaaa 2861221 gcattttccc gtaagcttta cgcacagatt cagcaatcgg atgctgtgaa tgaagctcag 2861281 cgtatgccgc cgcttcaagt aatctatcct ttgtaaaacc ttccgcgggt ttgatttctg 2861341 tcacttcaaa gctgcctttt gttagtgttc ccgttttatc aaacaccgcg tatttgactt 2861401 gattcaaagc ttctaaataa ttgcttccct ttacaagcac tccggccttt gaggccgctc 2861461 cgattccacc gaagaaaccg agcggaatag agacaacaag cgcacaagga caagaaatca 2861521 ctaaaaagat aagcgcgcgg tacacccaat cggaaagcgc ggcgccagaa agaacaagcg 2861581 gcggaacaaa ggccagcaat accgcaatga tcaccacagc aggtgtataa tacttggcaa 2861641 acttcgtgat aaagttttct gtccgggctt tacggctgct cgcattctga accaagtcta 2861701 atatttttga tactgctgat tcctgatagc cctttgtgac ttcaatatgc agaacgccgt 2861761 tttgattgat aaagcctgac attacatctt gtccttccgc agcttttctc ggaacggact 2861821 cacctgttaa agcagatgta tcaaccatcg ctgacccttg cacgacctta ccgtccaggg 2861881 gtatgctttc tcccggatta accacaatga tgtctcctgt ctgaacgtcc tccgacgaaa 2861941 cctgttcgat gccgttcttt gttttgagat tggcgtaatc aggccgtatg tccattaacg 2862001 cactaattga ttttctggaa cggctgaccg cggctccttg aaaaagctca ccgatttgat 2862061 aaaacagcat aacggcgacc ccctcagggt attgctgaat cagaaaagcg ccgattgtgg 2862121 caagagccat taagaaatgc tcatcaaaca cctgaccgcg gatgatgttt ttgactgcgc 2862181 ggattataat gtcaccgccg ataatcaaat aagcaccgag gaaaaggaaa aattcaatgg 2862241 ttcccgactg aaccaaatat gccgctgcgc cgagaatgac agccgccgcc attctgatca 2862301 gcatattgac cattcgatta cgatagccat catcagctga tttctttata tgcttttggc 2862361 gaaccgttac atgcggatca attgatttca cttttttctc tactttattc gtgacccatt 2862421 gctcttcttt cccatcggct gagacagtta aggtgcttgc cgcaaaattt accgcgcatc 2862481 cgttaatgcc ttttatgcct ttgactccat tttcgatttt tcgggcacaa ttgctgcaat 2862541 ccaaaccgtc cagaacatat tcctgtttca ctagtctcac cttaccttcc gatttagggt 2862601 tccctcttca aagcgtatca atgagtattg tatttatttt atatatatga gcatatactc 2862661 atatataagt tacacctatt atatgttgtt ttccaagaaa gtgtcaatga aaaacaaaaa 2862721 ccggcatata gccggttttt cattttactt tttgcagacg aagagcattc agaacaacgg 2862781 aaacggagct gaatgccatt gctgctcctg ctatccacgg tgctaaaaat ccaagtgctg 2862841 cgattgggat gccgaggctg ttatagccaa gcgcccagaa taagttttgt ttaatgtttt 2862901 tcattgtcaa tctgctcatg cggattgcgt cggcaatgct gttcagatcg ccgcgaataa 2862961 gtgtaatgtc tgctgtttcc atggcaatgt ccgtgccagt tccaatcgcc atgccgatgt 2863021 cagctgtggc aagcgccggc gcatcgttaa ttccgtcgcc taccattgct gtctggcggc 2863081 cttctttttg caagcgggcg atttccgccg ccttttgttc aggaagaact tccgcaatga 2863141 tattcgcaat tcccgcttcc ttcgcgatgg cttctgcggt tctgcgattg tctcctgtca 2863201 tcatgatgac atcaagaccc aactctttca gacgggcaac agccttccgc gacgtatcct 2863261 taatcgtatc tgcaactgct actagccccg ctgcttctcc atcaatggat acaagcataa 2863321 ctgttttccc ttcggcctct agctcttcca tttgggcgag aagagcccca tgctcaacct 2863381 gttcgctctc cattaatttt cttgtgccga cgagaatgct ttttcctccg gcttcagcca 2863441 aaatgcctgc gccgactttt gcttcaaagc gggtaagttt cggtatctca agccctttat 2863501 ctttcacgcc agcaataatc gcttcgccaa gcggatgctc tgatcccgtt tccgctgccg 2863561 ctgcaaattg aagcaaatct ttttcttcaa aacggccgaa tggaatggca tccgtcagac 2863621 gcggcttccc gtttgtcacg gttccggttt tatcaagaac aattgtatcg agacgatgtg 2863681 ttttttctaa atgctcgccg cctttaaata aaatcccgaa ttcagcagcg cgtccagatc 2863741 cagccattat gctcgtcgga gtggcaagac cgagggcgca aggacaggca atgacaagaa 2863801 ccgcaatgaa cttgctgatc gcttcggcaa aatcgccagg agccgcccaa agataccaaa 2863861 tgagaaaagt gagaaccgca atccccaata caatgggtac aaaaatgcct gaaatctggt 2863921 cagcgagacg ctggatcggc gcttttgacc cttgtgcttc ctcaacaatt ttgatgatat 2863981 gagaaagcgc agtatccttt ccgacgttga cagctttaat tttcagaaag ccgtttgcgt 2864041 taacggttga acctgtcacg ctgtcaccag gatttttgtc aacaggaaga ctttctcctg 2864101 taatcatcga ttcgtcaacc gctgaacggc cttcaaccac ttctccgtcg acaggaattc 2864161 gttcgccagg tttgacgtaa acaatgtcat taacaagcac ttcgtcgatc gggatgattt 2864221 gctcctgtcc gtctcttaca acagtagctg ttttcgcttg aagcttcatc agctttttaa 2864281 tcgcatccga ggaacggcct tttgcttttg tttcaaacaa cttgcctaat aaaatcagcg 2864341 tcagcaaaat cgcgcttgtt tcataataaa ggccgtctgt atgcccgtga gagccaatgc 2864401 tttgaaaagt tagataaaga ctataagcgt aagcagccgt cgtaccgagg gcgaccaata 2864461 catccatatt ggcgctttta tttctaagcg ccttatacgc acccacataa aacggccagc 2864521 cgatcagaaa ctggactggt gtcgccagcg caaactgcat ccacggattg agaaatatat 2864581 ccggtaccca aatgaatgat gtaaatgtaa aatggctcac catcgcccaa agcaatggaa 2864641 atgacaggac agctgaaaaa atcagtctcg ccgtttgctt ccgttcttct ttctttttag 2864701 cagcagcctc actgtcctgt tcacccttca actttagctt atatccaagc ttatctaccg 2864761 cttctttcaa atcgctgaca gacgcttctt ttggattgta ttcgaccgta actgtttcta 2864821 aagcgaagtt tactggtgca tttgcgacgc cttctatttt gttaagccgt ttttcaatcc 2864881 gattggcgca agccgcacag gtcatgccct caatatcgaa ttcagctttt tctgtaacga 2864941 cgtgatagcc cagcttctct attttttcct gaatcgctgc agtccctgtt tcagcaggat 2865001 cgtagattac atttgatgtt tccgttgcca gattaacatt tgcatccgtg acaccgggca 2865061 tccgcttcag gcctttttca attctggcag cacatgccgc acaggtcata ccagagacct 2865121 gcatcgcgat ttccttttgt tcactcaaca tactcactcc tttatataca cctggggggt 2865181 atataaaaat gaaagaaata tcgcgcctcc ctaaaggcgc gataccttga atcacttggc 2865241 tacgtcatag ccctgatctt ctatcgcatc cgcaatatct ttgactgata ctttgtcagc 2865301 atcaaacgaa acatcgactt tacccgcttc cagattgaca tgaacggcac tgacgccgtc 2865361 cagttctcct acgcttgttt ctactgcttt gacgcagtgc tgacaagaca ttccttcaac 2865421 ttgcaatgtt ttttgttcca tatcaattcc tcctgtttat tctttctatt ttcatcctac 2865481 catacccccg tagggtatta caataaaaaa cgctttatga ttttgtgaac tttttaaata 2865541 cgtccaaaag ctcagaaatg gcctgttccc cgtctccgct tttgatggca tctgctacac 2865601 aatgatgggc atgatcctca agcaaatgaa gcgccacatt tttcattgcc gcctgaacag 2865661 ctgaaatttg cacaagaata tctacacaat atctgtcgtt ttccaccatg ttttgaatgc 2865721 ctctgacctg gccctcaatc cgcttaagcc ggtttgtaat ctgatccttt tctttcgagc 2865781 ttttatggtt taatgtttta tgttcgttat gcttttccat gcgtacacct ctgtttaatg 2865841 atattaattc ccattatact gattgtccaa acggttgtct aagcatgccg acgcaaaaaa 2865901 tgaatcagtt aggttttacc atttgatcag gagggtatat acttctgttg ataacgcttt 2865961 taaaggggag aagaaaagtg gatacgatca aggttggaat attaggatac ggattgtccg 2866021 gttctgtttt tcacgggccg ctgctggatg ttctggatga atatcaaatc agcaaaatca 2866081 tgacatcacg gacagaagaa gtgaaacggg attttccaga tgctgaggtt gtacatgagc 2866141 ttgaagaaat cacaaatgac cctgccattg agcttgtcat tgtcaccacc ccgagcggcc 2866201 ttcattacga gcatactatg gcatgcatac aggccggaaa acatgttgtg atggaaaaac 2866261 caatgacagc aacggccgaa gagggggaaa cattaaaaag ggctgccgat gaaaaaggcg 2866321 tattattaag cgtatatcat aaccgacgct gggataacga ttttttaacg attaaaaagc 2866381 tgatctctga gggatccctt gaagatatca atacatatca agtttcctat aaccgctaca 2866441 gacctgaagt tcaagcgcgg tggcgggaaa aagaaggcac tgccactggt acgctgtatg 2866501 atctcggctc ccacatcata gaccaaaccc tgcatttgtt tgggatgcct aaagccgtga 2866561 ctgcaaacgt gatggcccag cgggaaaatg ccgaaacggt tgactatttt catttaaccc 2866621 tggattatgg caagcttcaa gccattctat acggaggatc aatcgttccg gcaaacggac 2866681 ctcgttatca aatccatgga aaagattcta gctttatcaa atatggaatt gacggacagg 2866741 aagacgcact cagagcggga agaaaaccag aggatgacag ctggggtgcg gatgttccgg 2866801 agttttacgg aaagcttaca accattcgtg gctccgacaa aaaaacagaa acgattccat 2866861 cagtaaatgg ctcctacctt acttattacc gtaaaatagc ggaaagcata cgagaaggtg 2866921 ctgcgctgcc agtcactgct gaggaaggta ttaatgtcat ccgcatcatt gaagccgcga 2866981 tggaaagcag taaagagaaa cgaaccatta tgctggagca ctaaaacaaa agcctcccca 2867041 aataagggga ggctttttca ttagaatgtt tttcctgctt ctttcgcacg cgcaatcgcg 2867101 tcttctttga tttgctgtgc tttatcaggc tccgcattat gtccctctac gaaaatgcca 2867161 tcgaatgatg gtacgccgaa gaagttcatc atgatgccga tgtagcggtg ccccatttcc 2867221 atctcagccg cagggccttc tgaatagtag ccgccgcgcg cttggatatg aattgctttt 2867281 ttatcagtta acaagccgac aggaccttgt tctgtgtatt tgaatgattt tcctgcaaca 2867341 gcaacagaat cgagatacgc tttcatcact ggcgggaatg agaagttcca taaaggagta 2867401 acaaatacgt acttatcagc tgatgcaaat tgatcgctaa gctctcccaa acggcctact 2867461 ttcgcttttt cgctttcaga aagctcttca aagcctgtac ctgactgaag ctttccccat 2867521 ccgctaaata catctgcgtc aatgtgcgga atgttttctt tgtacaaatc gatatgtaca 2867581 acttcatcat ttggattcgc ttctttgtaa gattcgataa atgctttacc tgttgccata 2867641 ctgtacgaag ttgcttcgtc atgtggatga gcagtgatat ataatacttt tgccattttt 2867701 accagccctt tcgtttttaa aaatcacaca tcaattatta tcatacagat gcataatgat 2867761 tattctgtct ctcttagact ttattataga gacaaagaaa tttactttca agtaaaacat 2867821 ctcgaattaa agattattta actttcccaa acagcttact tttcaaaagc tgttctcaag 2867881 ccggaataca gcgcggacaa ttctttactg atccgaggat aatgagggac atgcggcact 2867941 tgaatatccg caggcatcct tttcatgata aaggattgct cagcctgttc aaaaaacgcc 2868001 cgcagctggt tgatctcttc atcagaaaac ggagcagacg gacggcggtg agcttgcgcc 2868061 gagagcaaat agtaccctaa gtgctgagca ccggaaatgg caggccagag cgcatccgca 2868121 ttcgcgtgag gaaactcgcc aagcgccttg tcatacgcat cccgaagcct gacaagactc 2868181 acccttaact tgtgttcgtc ggcaatttgc ccggttaaca gtttctccat aaactgccct 2868241 tccagccgga tgacattccg cacaagttct ggcagccgct tggttgaaaa ccgccgccac 2868301 aaaagcattg ttcccaacag cccgatcacg ctgccgacag ctacatcagt cagcctcgct 2868361 atcataaaat aaccggcgcc cgccccgcca tgcatacttt ctgtgataac aagcgcattt 2868421 gcggttaaaa agggaacagc cagcgcataa ttgcggacga tcagcatctc aagaagacat 2868481 tgcagcgctg caatacaaaa cgcaatataa acaccgcccg gcttaaaaaa caggattgcg 2868541 cctgccagta taacaccgat caccgttccg gccgaacgct gaatagccct gtgaagcgta 2868601 aaaacaacag tagtgccaag catgaccgct gctgccgaaa gcggaatcca ataggagcgt 2868661 gcaaagccga atgcgagggc aaacatatcg gcggcaaaca gaacaattcc gtactttaac 2868721 gctctaatca aaactggaga cttccagtca aaggcatttc tcaaaaagta aaaagaggat 2868781 ggcaggcggc ttggttcccc gtcaagctgc ttatcaaaac gtcctgaagc gatatacaaa 2868841 acctcattga tttcttcaaa cagcttccgc ctaggctcag attcattttc attaatctga 2868901 aacgtattga aaacccgtgc attcgcaagc atatctccgg tttggcgaag tgccttttca 2868961 atctgcgcgg tctctctgtc cggcgtttca gctgaaaaat gaataatggc aataaatatg 2869021 tcgtcagctt tctcaaggag gcgaaaaaat cgttcatcat gccgcgattt tttccgtctg 2869081 ttccctttcc caagaaccgt ttggcgggct gttctaagca tgagcaccgt ctgatgctgt 2869141 gcgttatgaa aacctggcgt tccgacggct gaaagacatg cagccagctg atgatatgtt 2869201 ttttgcagca ccgctccctc cggtccatgt ttgttccata accagccgat taaagcgata 2869261 cccatggcga aaatgccgcc gagaaacgtc agtcccgctc tgaacagcgc ttgtgaagga 2869321 tcggccggca gcccggaact gactaaaaag gcaaggacaa aaaacatcgg cgcagggcct 2869381 tgaatgccga gcgcgctaaa aataaacatc gccgctgcac cgatcagccc caaaacagcc 2869441 gccatcatcc aaagcatccc ggacaaaagc gtccctaaac caaatgagag ggcgatccca 2869501 atagaaacca agagcagctt caaggcgcgc tttttgtacg attcaccgcc cgcatataaa 2869561 taaacaaagc ctccgatact tgcaattaat ccgtaatccg tgtgacctgc caatgcaccg 2869621 accagcacag gaaaccctga agcgaaacct gatccgatag cctttttcca aggaaatgga 2869681 tttgcatgaa tgcgaaaggc atccttcacg ataggcatga ttctttgatt gttcgcagca 2869741 gttttgttca tttgacaaaa tccttttcaa tgaatgtgta gaacttttcc agtttcttcg 2869801 ctttagtatg cccaaaaacg cggttagctt ctcaattggt gcgcacgata aaaaaacaga 2869861 gacttatacc gtctctgctt cattacatca gtttattata aaagcggcac ctgtcaggac 2869921 tgttttgtcc ttctgccttc cttcaagagc aggtgaataa aaaataaagg ataaatcaat 2869981 agatacccat taaacagcca ccacacaaga tcaaagtcac tgctgaatgt ccagaatgat 2870041 agcgcctgca gacctgaaca acaggtcagc acaagagaaa tcagcgccat cagcttccag 2870101 tcagcacgat tcacccgctg taggtacaag ctgtacaacc ctgtgacaga aatcaggata 2870161 tccagcggaa aaaaagacca gttccaagcg atcataaacg gatggtcatg atgtttaaaa 2870221 gcccagcttt ccggtatgag cgaaaatccg gctgacagcc agtacaagat aaaaccgata 2870281 tcagtcacga gaaaaaacag cttcatatat ctcatttgta ctgcccgctt ttatgtaccg 2870341 gctcagacac cgcaacatgc tcgatcaggt ttaaagacac aacaccggca ataatcaatc 2870401 caattgaaat gactttcatg acactcacat gttcttgaaa aaacaaaaaa ccaacgactg 2870461 taatcaagac aattcccatc cctgaccata cagcataagc aactgataca tcaatggatt 2870521 taagcgtaag cgtcagaaag aaaagactcc ctccataaaa gaaaatcaac agcaaactgg 2870581 gaataagctt tgtaaaacca gacgatagct tcatgctgac agttcccgca acctcaaaca 2870641 aaatcgccaa gcatagaaac acccaattca tgtggcatca gcctcctcat cagctgttat 2870701 accgttaaac aaaacatcta caattgattc aagtacctct cctgtcgtga actgatgttt 2870761 cagcggatat tcagggtcat acacttgatt gatgctccct atatacatgt gaacaaacag 2870821 gtccggattg atgtttctga ttctcttttg ctgtttgcac tcatttaata atgctaggac 2870881 aatcgcccat tcttccttaa taaacgcgtc taatgtaagc cacgcatcgt aatggtattt 2870941 ctttagttca tttaataatc ccatgttcag cagttccatc ccctgcggaa ggctgatcag 2871001 catttgtttc accttttcga gcacatttaa actttcattt tcatagatgt ctctttctat 2871061 ttgcttcatt tcagctataa attgttcgac aaccgcctca acaagctgat ctttagatga 2871121 ataatatgca tagagcgtcc gcttgctcgt tcccagcgct gccgccaaat cattcatcgt 2871181 aaatgaaaat cctttctgct tgatcagccg gaaggtttcc gccagaattc ttttatccat 2871241 attaatcccc cgctttcggt accaagaaaa ctatttcggt accaatatta tacggcagaa 2871301 atttatggaa atcaacaata tataaaaaaa cctctcctat tgggagaggt ttaaaagaca 2871361 ctgcggacca aaccgccgtc cgcccgaagt gccgcgccat tgatcgcaga ggaaagcgga 2871421 ctgcttaaaa atgtaacgaa gtgggcgatt tcttccggac ggatcagtct ttgaataata 2871481 gatgtcggcc ggttttcttt cataaaacgt gcctcagctt cttgaacagt caggttttca 2871541 ccaggataca gcgagttcag catggtttcc acaccctctg ttaaggtaga gcccggcatg 2871601 acggtgttga ctgtgacatt cgtgccggtt gccagctccg ccaaactgcg ggaaatggac 2871661 agctgcatcg tttttgtcgc actgtaatgg gccatttcct gtgacggcat aatcgccgct 2871721 tcactggcaa tgaaaatcac acgcccttct tttttctcta tcatgttatg caaatacctg 2871781 cgtgtcagcc ttacaccgct cataatattc acttcaaaaa aacgaaacca ttcatcgtcg 2871841 ggaatatcaa agtactccgc cggttcaaaa atccctaaat tgttgaccaa aatatcaacc 2871901 tctggatatg cctgaaacag ctcattgcag ccttcttctg ttcccaaatc aaatgcagcc 2871961 ggataaagaa ccgcttcagc atgttgtgtt ttcagttcat ctatcgtttg attcactttc 2872021 tcttcccggc gtccgttaat gatcactgcc gcaccttctt cagctaacga agaggcaata 2872081 gcttttccga tccctgatgt cgaaccggtc accagtgcgg tttttccttg taaattcagc 2872141 ttcattattc atccctccgt ttttgattcc tcttatttat tgacagaaat ctgattggtg 2872201 aaacatctgc tctgcaatca gtatgaaaca gctgggattg aaatggaagt acgcactttt 2872261 tggtgcctgt ggtttggaga aaaaataaag cagaacctct taagaggttc tgctttattg 2872321 tcagtatgta tggagacggt gggagtcgaa cccacgtcca gaaacatcga ttacttaagc 2872381 gtctacgagc gtagcctgca tatttatggt ttcactcatc ttcttgcctg cgggcgggcc 2872441 ttccgagagc tagtctgttc atctcttctt acgttctcag acgggaacgc aagcgtagcc 2872501 tacttggatg tgctcttcac agacacatag gcaatgtcag gaagagctcg ctgcgcttat 2872561 taggcagcta atgctacgtt ttggttaaaa ctgttagttt tgccagttat atttaagtgc 2872621 gtgtttacga gatcgcctct cggctcgcag ctcaagctcg atccatccct gtcgaatccg 2872681 taacgtcccc ttggtataag ggaaatacgg gagaaaatat caagctctca ctcaaactgg 2872741 ctatagtctt attataacat gatcacggct cttttcaatt gtcaaatcct tcaaatgaat 2872801 ggcgtcgtga tctgatcgtg aacacagtat agcacaggcc tgattttcga atcaagcact 2872861 atgcctttag aagccttttt gactgtctct gaacgctctt tcgatttccc gcttcgcgtc 2872921 cttgcgcttc agatcttccc gtttgtcata gttcttcttc ccttttccaa ggccgagaag 2872981 cactttggca aagccgtttt ttaaatacag cttcagcgga acgagagaat agcctttttc 2873041 ctttgttaac ccgatcagct tattaatctc cttgcggtgc attaacagct ttcttgtccg 2873101 gagcggatcg tggttatagc ggtttccctg ctcatatggg ctgacgtgca tattgtggag 2873161 aaacacttct ccccgttcga ttttggcgaa ggaatcctta aggtttacgc ggccggcgcg 2873221 aatcgatttg atttcggttc cttgcagaac gatgcctgtt tcataggttt cttctataaa 2873281 ataatcgtgg ttggctttct tattttgaga taatactttt cctgaccctt ttggcatgcc 2873341 agaacctcct ctctctaagg aaaaactgtc caccttttgc gatacgctct attttaccaa 2873401 atgtcacgta ccgctacaat gaaaagctgt ttccgaaaga aagcaaatag agcgctgcgg 2873461 ccctatttgc tggttgagct gctatttctt ctttttccgt ttctgtttcg gagcattctg 2873521 gaagccgcgt tttttctttt tcttcttcgg cttagtgaac cactcccctt tttcctcaga 2873581 cggagctgga gaaacaggtg tattggtgct ttgaacacgt tttctggcag gctttccgcg 2873641 ttttctgctc cggctgctgt ccaattctct cggacgccgc ggagtgcctt tcatgccgac 2873701 aatttcaaag tcgatattgc gctcatcttt attgacatcg acaaccttga ctgtgatttc 2873761 atccccgatg cggaagacgt tgcctgtccg ctcgccaatc attgcgaaat gctgttcgtc 2873821 aaagcggtag tagtcatctg tcataaagct gacatggacg agtccttcaa ttgtattcgg 2873881 cagctcgacg aacattccga agtttgtcac agagctgatc atgccgtcaa actcttcacc 2873941 gattttatca agcatgtatt ccgctttttt cagatcatcc gtctcacgct cggcgtcaac 2874001 tgcacggcgc tccatagatg atgtatgttc ggcgatatcc ggcaggcgtt cagcccactt 2874061 ttcctgtgtc gcttcatcga ccttgccgtt gatcaaatac gttcggatca gacggtgaac 2874121 gattaagtcc gggtaacggc ggatcggtga tgtgaaatgc gtatagaatt ccgttgacag 2874181 accgaagtgc cccaagcttt gcgggtcgta tttcgcctgt ttcatcgaac ggagcataac 2874241 agtagatata accgtttcct ctggtctgtc acgcacagcg tccagaatgc tttgcagcgc 2874301 gcgcggatga atattccccg ccgttccttt caccacatag ccaaatgtcg tcacaaattc 2874361 taaaaacttt tgcagctttt cagcattcgg ctcttcgtga atccggtata taaacgggac 2874421 attcatccaa tggaaatgct ccgcaactgt ttcgtttgct acaagcataa attcttcaat 2874481 cagcttctcg gcgacagagc gttctctgat cacaacgtct ttaaccgctc cttcgtcatc 2874541 aacaagcacc tttgcttctt tgaaatcaaa gtcaacggcg ccgcggtcca tccgcttatc 2874601 gcgcagaatt tgagccagac gctccatgtc tttgaacatc ggaacaagag gctcgtattt 2874661 ttgtttcagc tcttcatcat catcaacaag aattttattc acatctgaat atgtcattct 2874721 ttccgttgtt ttgatgacac tttggaagat ctcgtgctct gtcacctgtc cctgactgtt 2874781 aattgtcatt tcacaagaaa gcgtcaggcg gtcaaccttt ggatttaagg agcagatgcc 2874841 gtttgacaat ctgtgcggaa tcatcgggat gacacggtca accagataca cacttgtccc 2874901 tctttcaagc gcttctttgt caatcggcga gttttcggtt acgtaatggc tgacatcagc 2874961 tatgtgaacg ccaagcttgt agcttccatc atcaagcttc gtcacggtaa ctgcatcatc 2875021 caaatccttc gcatccgcac catcaatggt gacaatcacc tggtcacgga gatcacggcg 2875081 gtctttcaga tctttttcat caatcgtgtc aggcgtactt gatgcctgtt ccatcgcgtc 2875141 agctggaaat tctcccggca ggccgtgctt atgaatgacc gataaaatat caatgcccgg 2875201 gtcgtttttg tggccgagaa tggtttcaac ctcaccctct gcgttcatgc ggccttcagg 2875261 atagctcgtc agcttgacaa caaccttatg cccttccgca gctccatttt tcccattttt 2875321 cggaatgaag atgtcactcg tgattttttt gtcgtccgga atgacaaagc cgaagtttct 2875381 cgtttctgta tacgtgccga caacccgctg aatcgctctt tctaaaatcc gtatgacggt 2875441 tccttcctgc ctggagccgc ttgattgtga gttcagacgc accatgacga tatcgccgtt 2875501 cattgccgta tttagctcat taggcggaat aaacacatca cttaacgacg tatcctcagg 2875561 cagcaaaaag gcgaatcctt tcgcatgggc tgaaatcttt ccttttatta aattcatctt 2875621 ctccggaatg ccgtagcggt cgcttctcgt ccgtacgata agcccttttt cttccaaggc 2875681 gactaacgct ttgacgagct ctttaaactc ctcggcttcc gtaatattta acatctcctc 2875741 aagttcctga acggtcagag gtttgtacgc ctcttccttc ataaacgaga gaagcttttc 2875801 cataaatgct tctttttcca ttatccgacc tcctgttgat taccaatcga gcttctctaa 2875861 aaattcatac acatcctgat ggacgaggtc acgttctttg tcgagtgtaa tgacatgccc 2875921 tgattcctcg taccatttca gctgtttatc atcagtttcc acttcgttgt aaataatatt 2875981 ggcgctttcg gtattaatca tgtggtcatg acgggcctgc accacaaatg tcggtgaata 2876041 aatcatatcg acattattcc gcacatcagc aattaagtct tgcagcgcct tgagggtatt 2876101 catcggcgtt ttttcgaatt ctttcatttc ctcttcaatt tgctccgggc ttttcccctc 2876161 aaactttttg taattgcgag cgtatgaaag aacgccttga tacatgacct cttcactctt 2876221 aatatgcatc ggtgcgcaca ttgggacaat tccctttatg ggtacagtgt aacccaattt 2876281 cagcgaaaaa accccgccaa gcgacagtcc gcaggcagca atgctctcat aaccttcaga 2876341 ttttaaatat tcatagccat ccattacgtt tttccaccag tcttcgggcc ccgtatgtac 2876401 aagttcttca ggcgggacgc catgtccttc atattgaggc gcgtggcacg tatagccgcg 2876461 ttcattcaaa tatcgtccca gcatccttac atccgctgta tttcctgtaa agccatgcag 2876521 caaaagcacc gctttgtctc cgcctttaaa tgtaaatggt tttggtgtca caactttcat 2876581 gctcatgtct ccctttctat ctgcacgatc attttagttt tccacagttt aatcagaaaa 2876641 aaacgttttg aatatcatcc agaaacgtga aaaaggcctg acttcacatc agaccttata 2876701 caaacattgc cctataggat ataagcaagc gcaatcgtta acacgaaaaa caagactgcc 2876761 agcactaccg taatgcggtg caaaattaaa tcaagacctc ttgctttttg tttcccgaag 2876821 agctgctccg ctccgcctga aatcgcacca gataatccgg cacttttact ggattgaagc 2876881 aaaacgacaa taataagtgc aatgctgacg ataaccaata aggtaatcaa aactgcgtgc 2876941 atcccataca cctccagact cactggctac attacttcta ttttacatga aaagggttgg 2877001 catgtcacgc tgtatcagac gccaaaaggc cggataagac gttttatctt ggttacccta 2877061 ttcatatgaa aaggtcaaag gagaaaagcg atgccgctta tcagcataga cagcaggaaa 2877121 catctttttt atgaagaata tggacaggga atccctatca tttttatcca cccgccgggc 2877181 atgggacgaa aggtttttta ttatcagcgc cttctatcca agcatttcag ggtgattttt 2877241 ccggatttaa gtggccacgg tgatagtgat cacatcgatc agccagcgtc tatttcctat 2877301 tacgcaaacg agatcgcgca attcatggac gctttgcaca ttgataaagc tgtgttattc 2877361 gggtattctg ccggaggctt aatcgcgcag catatcggct tcacccgccc ggacaaagtg 2877421 tcacacctta ttctgtccgg cgcctacccc gctgttcata acgtaatcgg ccagaagctg 2877481 cacaaactgg gaatgtatct gcttgaaaaa aaccccggtt tgctcatgaa aatcctcgct 2877541 ggcagccaca caaaagacag acagcttcgc agcatattaa cagaccatat gaaaaaagca 2877601 gaccaggccc attggcatca gtattatctg gattcgcttg gctacaactg cattgaacag 2877661 ctgccccgcc tagaaatgcc aatgctgttt atgtatggcg gcctgcggga ctggaccttt 2877721 acaaacgcag gctattaccg aagatcgtgc agacatgccg aatttttcag attggaatat 2877781 cagggacatc aattgccgac aaaacaatgg aaaacgtgca atgagctggt gacagggttt 2877841 gtgctgacac atcattcata ggaatagaaa acgcttggct tccttgcgtt ttttgttact 2877901 ttattgactt ttgtcaacga aatcatagta aaaaagatcc tcaaatttca aattaaaata 2877961 gtgaagcatt ttaccaatca caagctgccc cggccttctt tctccattca gcacgcggct 2878021 cagtgtggcg ggtgagactc cgatttccag cgcaagctga ttaagggaat aatcgttatt 2878081 aaccatatac tgcaagacat aatcacgtct aatctgtatc ttttctactg gcactttcct 2878141 caccttccat tcctgaaaaa cttttttcta tacttttaca ttacggctta tgttaacttt 2878201 tgtcaataca tttccagtct acctattccc tttagtcaat aaacatacta aaatatgagt 2878261 aacagtgagg gacggggtga gatatatgga aagctttggc gaacaattac gggcattgcg 2878321 tgaagagaga aagttaacag tcaaccagct ggcgacttat tcaggcgtaa gcgcggccgg 2878381 catctccaga atcgaaaacg gaaaacgggg cgttcccaaa cctgccacca tcaaaaaact 2878441 ggcagaggcc ttaaaaattc cttatgaggg gcttatgtac aaggctggtt acatcgaaga 2878501 agtgcatgaa gccagggccc cttatgaaac gaagtgcaag ctgcttgaaa aagcggaggc 2878561 ctatgacctg aaaaaccttg cgcttcttga gaacgaaaag tggcaatatc tcaataaaga 2878621 agatttgctc atgctggatc attatttttc gtttatttca gatgaagcga aaaaacggtc 2878681 tgctgatgac tgactcttga tagaaatgtg aggcgataga ccatgtcacc gttcggacag 2878741 caattacggg agctgcgccg cgcccgcaaa ctgacagtga atcagcttgc ggtgtactca 2878801 ggcatcagct cggccaccat ttcaaaaatt gaaaacggca aacgcgggac gccaaaaccc 2878861 gccacgatta aaaaactggc agccgtcctg aaagtgccgt acgaaaacct aatggccgcc 2878921 gcaggccata ttcaggcctt tcctgaagaa atccgcgaag catctgaagg ctatcaatcc 2878981 gtttatgaaa tttaccagac ggctgtcaca cgcggagcgg agcacctccc gattttcaat 2879041 agtcaaaaat gggaacatct ctcaaagcag gatattgaaa atctcagcaa atacttcgat 2879101 tttttgtctt cagaagcaaa aaaacgcgcc tcttcctcat aatcccctgt ttctctttct 2879161 atattttatc aatcacgctt gcatgccctc cctcgttatt tgcgttataa tagtgacaga 2879221 cgaggtgaaa agtatgaacc aatcagaaat gtgtcctaga tttgaaaaag cagtcgacat 2879281 cttaagtaaa cgctgggtcg ctttaatcgt atttcagctc ttgaacgggt cgcagcgatt 2879341 tagcgaaatt gaagcagcac ttccaaatct aagcggcaga gttctgtcag aacggctgaa 2879401 agaacttgag cttgaaggag tagtgaagcg ggatgtcatc cctgaaactc cggttcgcat 2879461 cgaatattca ttgactgata aaggaaaggc actagcaccc atattaggtg agatttctaa 2879521 atgggcgact gaatggattg acccttcctt tcttgactaa ttgctaaaat ggttctgatc 2879581 tcaaagacga gaaaagaacc gttttttatt ttccaggtga aaaaaagata tctcagccga 2879641 tatatagtac atccacacat tacgttttta aaggagacca ctatatgcga ctgacgattt 2879701 cccgcaaatt cagcctggta tttttgacac tgatcctgat caatttactt gtaggcggaa 2879761 taggcgttct taatatgcag catatcattc aaaaaacaga tgaaatcaac acaaaatgga 2879821 ttgacggcat caaaggaatc acttcaatta attatgtaac cgagcacctg tcttctaaag 2879881 aaaaggactt tctgatttat acagacaaaa gtaaaatgga tacacttgat caagaaatga 2879941 atcaaatcat ggaagacatt aaccaaaagc tcgataacta cgaaaaaacg atctccactg 2880001 ataaagagca gaaactgttc gagcagcttc aaactaaagt gaatacctat atggatattc 2880061 atgcgcaaat tatcgaaagc ggccgcacga atgacatgga caaagcaaga ggtttattgg 2880121 ttcagactga ggccagcttt gaggatatga aaaaaacaat cactcagctt gttgacttaa 2880181 atcaagaagg cagcaacaca gcggtaaaag aaacgaaggc cgtctatcat aaagggctca 2880241 tttacactgc tttgcttgtg gcagcatcaa tcctcatcag cattttcatc tggctttata 2880301 tcacgcgaaa cattgtaaag cctatcattc gcatgaagga atctgccaat catattgccg 2880361 aaggcgattt gtcgaacgat atggaggccc tcaactcaaa agacgagctg ggtgatctga 2880421 atgaagcgct gcaaaaaatg gtagggaatc tgagagatat tgtcggatat tctaaagaca 2880481 tatcaagccg ggttctttct tcttcacagg tgcttgcaac cgcaacgaat gaaacaagat 2880541 ccggcagcaa acatattacc gagacgatga acgaaatggc tgagggctct gaacagcagg 2880601 cccaagacgc ggtgacgatt gccgaatcga tgaatgagtt taccgaaagc attgataaag 2880661 cctataatca cggcatcaca atcagcgata cgtctcaaaa cgttctcgaa ctcgcggtaa 2880721 gcgggaacga aaatatggct acgtcattac agcaaatgaa aaccatccat catattgttg 2880781 aagaagccgt gcataaagtg agatcactgg aacagcattc tcaggatatt aacaagctcg 2880841 ttcaggtcat caacgggatt gccgagcaga cgaatttgct gtcccttaac gccgcgattg 2880901 aagctgcccg cgctggagaa agcggcaaag gcttcgccgt tgtggcagag gaggtcagaa 2880961 agctggctga cggcgtttct gattccgtgc aggacattac ccggattgta aacgggacac 2881021 agcaggagat ccacactgtc attacgtact tggaaagcag ctttacagaa gtcgaaaaag 2881081 gaacggaaaa cctgacagac accggacagg ctatgcagca tatcaaacaa tccgtcaccc 2881141 atgttgcaga cagcattaag gaagtaacgg atggcttgaa gcagttaaca aaccaatcga 2881201 ttaccatcaa tcaatcgatt gaaaatatcg cttctgtatc cgaagagtct gccgccggca 2881261 ttgaagaaac attttcaatt accgagcaat ccgcccattc gatggatcaa gtgcttctaa 2881321 atgctgaaga gcttgagcag ctggccaatg agcttaatga gaagatgggt cagtttacga 2881381 tttaaagaga aaaaagaggc tggactccag cctctttttc tattctatgc agctgattga 2881441 acatgtttcg ccccggttct ttttttcttc accggactta atgcccgctc cagccaagcc 2881501 atgagcaaat ccgcccctac cgccatcacc gcagttggta tcgctccggc tagaataatc 2881561 gcagttccgt ttgttgcgtt tgagccgcgt acgatcatgt ccccaaggcc tccggcaccg 2881621 acaaatgtgc cgatcgctgt aattccgatg gcaatgacga gagccgtgcg aaggcccgcc 2881681 ataatgacag aaagtgcgag cgggagctca accattctga gcacttggaa tttcgtcatg 2881741 cccattgctt ttccagattc taagtaggca tgttcaatac tgataatgcc tgtgtacgtg 2881801 tttcgaataa tcggcagcag ggaatacaga aataatgata gaatcacggt atttgcgccg 2881861 agccccataa caagcattaa gacggccagc atagcgagcg ccgggattgt ttgaataacg 2881921 tttgttacgg caaacaccca ggctgacaaa cggcgaaaat gcgcgatgag gattccggcc 2881981 ggaaccccga cgacagcggc aaataaaacg ccgtaagccg acatgagaaa gtggcggccg 2882041 aattcatcca tgacgtaact gccattctgc gcgtaatacg tcattaactg ttcaagcacg 2882101 ttcattgacc tcttccccct ttcacgattc gaaatagcga tgtttttcta aatattcctt 2882161 ggcaacgaca gacggttctt tgagattgcc gtcgacttca tagttaagct cctgcatcgt 2882221 ggctgtgtcg atttttccga gcattttctt gatgatgcct tcaagttcag gatgttcttt 2882281 gagcaccttt tccggaacaa ccggagagca gtcgtacggc gggaaaaatt gtttatcatc 2882341 ctttagcatt ttgagaccat aggacttgat tcttccatcg gttgaatacg caagcacaat 2882401 gtccattttt ccgcttttca ccgcgtcgta cacaaggccg atctgcatcg gatacgtgcc 2882461 gccgaatgtc atgccgtagg ttttcgtaaa atcctgatag ccgtttcctt tgagcttcat 2882521 ccaatagtta tcaacgccca gctttaattg cggcgcccat tttttaacgt ctgatacggt 2882581 ctctaaatgg tattggtcgg ccagctcctt gctgactgta aaggcatatg tattatcaaa 2882641 cccgtaggag tcataccact ttaaatcata tcttttttta aactcccgct gagtaagcgc 2882701 cagcgctttg tccggatctt tttcaggttc cattctcaac gtgcctgtca gcgcgtctcc 2882761 cgtatatctt gtggccgcaa tgtcgatttc cccgttcatt aaagcctgct gctgcaccgc 2882821 gttggagcca agatttttaa tcgttgttgt tttgagatca gtatggtgtt cgatcaactg 2882881 gccaagcatg ctggcgatga tttctgattc gctcatgctt tgcgcgccga ttttaatggt 2882941 ctggtctgca gcagcgctga gaccaggaag cgaacagccg ctcagcgtca gcgttgccgc 2883001 aagtgctaaa cctatcatta atttgagata ttttcttttc atgagccgcc tccttatgac 2883061 aattccttca atctctgcat gccggcaggt gtcagttttc gttcagcaac tgccagcaca 2883121 taatcaatca caattgccaa tatcgtgaca ggtaccgcgc ccccgatgat atattccggc 2883181 tgatataaat tcagtccgat aaaaatgtaa tcacccaatc cgccgcctcc gataaaggaa 2883241 gcaagcgtgg cccagccgat taagtaaatc gtcgatgttc tgattcccgc catgatcact 2883301 ggtgcggcaa gcggcagctc caccaagcgg acttgttcag ccggcgtcat tcctattcct 2883361 ttaccagact cgagcagatt tttgttgacg ccgcgaatgc cggtatacgt gttgcgaaga 2883421 atcggcaata cggaatagaa aaacaaagcc acaatggccg gaaccttccc tacaccaagg 2883481 agcgggataa aaaaagcgag gatggccaga ctcggcagcg tctgaatgat attgacaatg 2883541 ccgataatgg tgccggctcc ttttttcatt ctggtaagca caaccccgag ggggacggca 2883601 accagcacac ctaagatcac agcaatgagc gatatcgtaa tatgctcgta tgttttataa 2883661 agaagctctc ccccattggt ttgcaaaaat tgaacaatat gatgcatgac ttatcgcccc 2883721 tccctatgac aatgctgcga gctgcttttc ttctccccag agggagtcat acacgatgtc 2883781 gaccagactt gccctcgtca caattccgat caggcgtcgg tcttcatcca caacgggaac 2883841 atatttgaca ccccgtttta aaattttgcg gaccgtgtcg cgcagcagtg tgccgcccag 2883901 tactgtgtat atatcttcat gtaaaacttc actgacgaga ttggcctttt tccggcattg 2883961 atcaatgatt tcaacatcga catagccttg cagaacgcgc tcgtcattga cgaccagcaa 2884021 tgaatcgacc cgttcctgcc tcatcagctg aatggcctca gaaagcgttt tatccgcggt 2884081 gatcgttaca ggctgtgtgt tcataatctg gtcaacccgt tcaacatccg ggctggatga 2884141 ctgaatcagc cgctccttgc cgataaattc ctcaacaaat tcgtctgccg gatttcttaa 2884201 aatgtcatcg ggcgttccaa cttgaacgat ttctcccgct tttaaaatca caatccggtc 2884261 tgccagctta atcgcttcat ccatatcgtg ggtaacaaat acgatggttt tatgtaaggt 2884321 tttttgcagt tttttaaatt cttcctggag ggaatccctc gtaatcgggt cgagtgcccc 2884381 aaacggttca tccattaaga taagcggcgg ctccgcggca agtgcccgta atacaccaat 2884441 tcgctgctgc tgccccccgc ttaattcatg agggtaacgg tctacatatt ctggccccat 2884501 atcgaccaat tttaaaagct cacgcgcccg ctctttccgc tgctgctccg gccatttcag 2884561 cagttttggg acgagtgaga tattctgctg aatggtcata tggggaaaca ggccgatctg 2884621 ctgaatcaca tagccaattt tgcgcctgag ctctacagga tcctggtcca tgatgttttc 2884681 gccgtcaatg aaaatcttcc cggcggaagg ctcaattaat cggttaatca ttttcattgt 2884741 tgtcgttttt ccgcagccgc tcggcccgat aaagcagata aattcgcctt ttgcaatctt 2884801 aagatttacg ttgttcacgg cttttttgcc gcccttgtat gttttcgaga cattttctaa 2884861 tgtcagcaaa catcgcacct ccaaaattaa gtttattcaa tttgttcagt ttaaatttaa 2884921 tttttcagac aattgaatgc ttcccattat agaataaagt ttataaaata aaaagtttac 2884981 aatttgttca tattatttat aaagtatgtg taaacgctga tttacccgca ttgacgtgtg 2885041 ttgatctcct tattgctcca atttcctgcc aaattctctt ttgacagcat tttcgccgta 2885101 tcaaaaatgt ggtatattga catcggaatt gttagctgaa aggatgaaac cgttggagaa 2885161 agatccgtta acgatcattg aacaagccga ggaccatttt atagaaagaa tcgcggaaaa 2885221 catgcatgca tttggaatgc cctctaccgt cggacgagtg ctgggcatta tttatatgaa 2885281 tcgaaaaccg atgacgctta cggaattatc tgaggccacc ggcatgagta aaacacgtat 2885341 gagccaggta gtgcgggaaa tgcttgatgc caacattgcc gagaaggtat tcgaaaaagg 2885401 cgtgcgaaaa gatttatatg aggttgagca ggactactat caaacattta tcacgctgtt 2885461 ttcagccacc tggagcaaag tcgtcagcaa aaacaaaatg atgcataaaa aactcaatcg 2885521 ggagctgctt agcgtgttgg atgaagagct tactcctgaa gcggaagaaa aagtgaatga 2885581 gctgctgaag gaattaaagg aatggctcga ttattataat tggctcagcc gtttgattga 2885641 gttttttgag agcgaagaca tttttaaata tgtgccgaag ccgtaaaaag ttcccaaatt 2885701 caattctggg aactttttta agtccaatcc aaatggttga atatcaaact tcgagctccc 2885761 aacgctggaa aatatgttta acagatacta acacatgttg tttatttaaa aaaaccacct 2885821 ctgttgtatt taaatagagg tggtttttct atcagctata ataaaatttc cttttttctt 2885881 tttaatcggg cttaatgctc gttcaagcca gcccatgacc aaatcggcaa tcaccgccat 2885941 cagagctgtg gggatcgctc ccgctaatat aatcgcggtt ccgtttgtgg cgtttgatcc 2886001 tctgacgatg atgtccccga gaccgccagc accgacaaat gtcccgatgg ccgtaatgcc 2886061 gatcgcaatg acaagcgcgg tgcgcaggcc ggccattatg acagaaagcg caagcggaag 2886121 ctcgaccatc cgcagcactt gaaattttgt catccccatt gcttttcccg attcaagata 2886181 ggcgtgctca atactgataa tccctgtata cgtatttctg ataatcggca gaagagaata 2886241 cagaaataat gacaatatca ccgtattagc gcccagcccc atgacaagca tcagcacggc 2886301 gagcatggcg agagccggga tggtctgaat gacattcgtg accgcaaaaa cccatccgct 2886361 taatcttctg tatctggcta tcaggatgcc gagcggaatt ccaacaatgg cggcaaataa 2886421 aacgccatac accgacatca gaaaatggcg gtaaaattcc tgcagcacgt aaccgccgtt 2886481 ttgcgaatag tatgtgccaa gctgctgtag tacttccata tgatccacct cttttcttag 2886541 tcaaaataat gatgtttctc taaaaattcc tttgctacga cagacggctc cttcagcttg 2886601 ccatccacct cataattaag ttcctgcatc gtttccgtgt cgatttgccc aatcagctta 2886661 ttgatcacac cttcaagttc cggatgctcc ttaagcacct tttccggaat caccggtgaa 2886721 cagtcatacg gcggaaagaa acgcttatcg tcttttaaga ttttcagatc atatgcttta 2886781 atccgtccat ccgttgaata agccaaaacc gcatccattt tcccgttttt gactgcgtca 2886841 tagactagcc cgatctgcat tggataagtt gtgccgaact caaagccata tgtgctgaca 2886901 aagcctttat acccgtcgcc ttttcgtttc agccaagcat tgtcgacgcc taatttatat 2886961 tgggaagcat ttttcttcag gtcagacacg gtgttaatat gctccttttc cgcaaacttt 2887021 tttgttacgg tgaaggcata tgtgttatca aagccgtagg aatcaaacca tttataagaa 2887081 aagcgctttt gaaactcgtt ctgcacaatg ttcagcgctt ttttcggatc tttctccgct 2887141 tccttgccga gggtgcttgt taaatctgtt ccggaatagc gcgtggctga aatatcaatg 2887201 tcaccgccca gcatcgcttg gtgctgaaca tagtttgagc cgaggttttt cactaaagca 2887261 gtattcaaat ctgtatcatg ttcaataagc tgcgcgatca tattcgctac aatttctgat 2887321 tctgtcatgc tctgcgcccc gattttgatc gtatcgtcag aagcgccgcc tagacccggc 2887381 agagagcagc cgcctagcag catgacaaag acgagagcaa acgcgccaag ccatttgatt 2887441 tttgtcattt tcaacagtgc caactcctta cgatacttcc ttcatccctt gcaagccttt 2887501 cggcgtcacc tttcgttctg tcacagccag aacataatca ataataattg ccagaattgt 2887561 gacaggcacg gcaccgccaa tgatatattc aggctggtat aggttcagtc cgataaaaat 2887621 atagtccccg aggccgcctc ccccgataaa cgacgcaagt gtcgcccagc caattaggta 2887681 gatcgttgat gtgcggatcc ccgccatgat gatgggaatc gccagcggga tttcaacgag 2887741 ccgaatctgc tcccagccgg tcatgccaat tcctttcccc gattccagga ggtttttatt 2887801 tacaccttta atgccggtat acgtattgcg caggatcggc agtaccgaat agaaaaataa 2887861 agcgacaatc gcaggcactt ttcctacgcc gagaagcgga ataaaaaagg ctaaaatcgc 2887921 cagactcggc agggtttgca caatgtttac gaaaccgata accgcacctg cgcctttttt 2887981 cattctggta agagcaacgc cgagcggcac tgcaacgata atgcccaata caacggctat 2888041 gagtgaaata tataaatgct ctcctgtttt atacagcagc tctccgccgt tcgtttgcaa 2888101 aaaagtcatc atttgattca tcttaaaaga gctcctcccc tggtcagatc gtcatgagct 2888161 ggttttcctc gtcgccccaa atggaatcgt atacgatatc aacgaggctc gctcttgtca 2888221 caatccctgc taaatggttc tgttcatcga ccaccggaac atacttgatc ccctgcttca 2888281 aaatttttcg gactgtatcg cgaagaagcg cccctttttg aacggtatat atatctgaac 2888341 ggtatacatc gccaacgatg ctcgcttttt tgcggttttg atcaatcatt tccacatcaa 2888401 catagccctt cagcacgttt tgccggtcca caacgagcag cgagtcaaca cgtttttctc 2888461 tcatcagctg aatcgcctga gaaagcgttt tgtccgcaga taccgtcacc ggcgttctgt 2888521 tcatcatttg ctctacccgc tcgatatccg gtcttgactg aatcaggcgc tctttcccga 2888581 taaattcttc aacaaactca tttgccgggt ttcgaagaat ctcatcaggt gtgccgactt 2888641 gaacgatttc tcccgctttt aatatcacaa tcctgtcagc aagcttaatc gcttcatcca 2888701 tatcgtgggt tacaaacaca atcgttttgt ttaaggttct ctgcagtttt ttgaattctt 2888761 cctgaaggga atcacgcgta atcggatcaa gcgctccgaa cggttcatcc attaaaatga 2888821 gagggggttc cgctgccagg gcgcgcagca cgccgattct ctgctgctgt ccgccgctga 2888881 gctcatgcgg ataacggtct aaatactctg ggcccatatc cacaagcttt aacagctcgc 2888941 gcgcccgttc tttccgtttt tcctcaggcc atttcagcag ctttggtacg agtgagatgt 2889001 tctgctggat ggtcatatgg gggaacaaac caatctgctg tatcacatag ccgatttttc 2889061 tcctcagctc aaccgggtcc tgttccataa tattttctcc gtcgataaag atccttccag 2889121 acgatggttc tatcagtctg ttgatcatct tcatcgtcgt cgtttttccg cagccgctcg 2889181 ggccgataaa acagataaat tcaccttttg caatatctaa atcaatgctg ttcacagctt 2889241 ttttgccgcc tttatatact tttgacactt gttccaattt cagcaatccg tgcacctccg 2889301 caggtttcct ttaaattttc tgaaaagtat aatccttatt atagtttgaa ctttgtaaaa 2889361 taaaaagttt acaatgtgtt gaaattatat gttatttata gattatttat tgttatgacc 2889421 gagacggaaa gggtgttctt acaattactc cggatacctc ccacttcctc tgcattcagc 2889481 tattttcaac accaggaaga aatatgatat attgacacca tcaattgcca tttgaaggga 2889541 tgatcagctg tgaaaaaaac cgctctcgac atcattgaac atgctgaaga gcatctcatt 2889601 gagaagattg ccgaaaatat gcatacgttt ggaatgcctt caactgtcgg acgtgtgctc 2889661 ggaattattt atatgaatcg aaaaccaatg accttaagcg agctctctga ggcaacgggc 2889721 atgagcaaaa cacggatgag ccaggttgtc cgggaaatga tcgatgccaa tatcgccgaa 2889781 aaggtgtttg aaaaaggcgt acgaaaagac ctttatgacg tcgagcagga ttattatcaa 2889841 accttcattt ctttatttgc ggcgaattgg acaaaggtcg tgagcaaaaa caaagtgctg 2889901 tataaaaaat taaaccggga gctgagtgat cttttacaaa gggacgggct taccccggaa 2889961 gcggaagaga aagtcaatca gctgctgaat gaattaaaag aatggcttca ttactatgat 2890021 tggctgagca ggttgattga attttttgag agtgaggaag tctttcggta tgtgccgaaa 2890081 acaaaagaat gcagctctct aaaataagag agctgctttt tgcatcatga agttaagacc 2890141 ggaaacatgc ctttcagccc ggcaccaatc atcccgaccg caaccacggc taagattaat 2890201 cccatcagtc tggtaatcac attcatctcg gtttttccga gtttgctgct gataaaagca 2890261 gaatagtgga aaaagagaaa ggtcagggca ataacggcgg ctatgccgat catgacagcc 2890321 gcataatgac caatgccgct atgtccggcg gaaaggctca tcactgttgc aatcgttccg 2890381 ggcccagcaa tgatcggaat ggataaaggt gtgactgata tatccgcttt ttccttgctt 2890441 tccttatgtt catcatggtg aagagattgc acgtgcgatt ctttcgcatt caatagatta 2890501 taggcaatgc cgaaaatgaa tatgccgccc gccactcgga gcgcgtgaat gttgatatca 2890561 aacagtttaa agataagatg accgaaaacc aaaaaagctg cgagaataaa aaaggataaa 2890621 atagctgcct tccgggcaat cgcttttctt tccgctgcag tatagccttc tgtcagcgtc 2890681 agaaatatcg gtacgtttcc gatcggattc gatactgcga ataaagaaat gaagacgtga 2890741 acgataaatg agaacatcat atacctcctt gttgatagtc tctgcacagg aaatagaatg 2890801 attctccacc cttttacccg gaggcgattt cccggtaaac ctttatagcc tgtcagaaac 2890861 gcgccatgct acaatgaagt gacaaattga ataggaagga cgtatacaga tgttcaaaaa 2890921 aattgcggca gatgccttgg gcttatctga tatcggaaaa attatcgaac ctcaggacta 2890981 tgacaaaaca gacgcagatg actatgtcat gcatgaagat aatgagaaaa tttatttctt 2891041 gattaaaaca aaagcagacg agtattgctt tacgaacctg gccctgatcc atgtggacgg 2891101 cgaacgcgcc acttcctcaa aacgaacgtt gaaacgctat ccttattcgc aatataaaat 2891161 ctctgacgtt tttcttgaaa ctgccggaaa agtggatttg gatgttgaaa ttaagttcaa 2891221 gctgggcggt gaacaattcg acattgatgt ccacaaagac cagattgaaa agttaaaaga 2891281 cctttataaa gcactgcttc gcatcgctga aacaacctat gaaaatgaca ttttaatcaa 2891341 tcaagcggag caaagcttag ataaagcagt gacgattctt caccataccc gccctgagca 2891401 cgtcaatatt gaaacgcaat acaaagagct gaccgaattc ggattcactt ggctgacatc 2891461 cgttcgctcg cagtatcata ttaaggattt tggggatgta tttgagaaat atattaataa 2891521 ctagataaaa aaagacacag ctgctatcgt gctcgtgtct ttttttgtat gaatattgat 2891581 tactttacaa cttttttctt ttataataaa actattagtc tattttccct atattacaga 2891641 taaaggagtt attttatgta ttgtcctcaa tgcggccatc aaacagatgg cggaaatttt 2891701 tgtgagaaat gcggatcacc gctccccggt caatcaggcc accagcatgc agctcaaact 2891761 ggagccgctg caaagcaagc agcaaaacag ttcggttcat ttgtcttatc cgtcctgaaa 2891821 cgcccttatc aggaatgtaa agcaacaggc ggagaacagc tgatcagcgc aatcattacg 2891881 atggttcttt tcagtttgct gacccctttg atgttttata ttcttttttc agacggtccc 2891941 ggaagcgtaa gctttacagc aatcttctta gagccaacca tttattttat tttatttcta 2892001 tttggcctgc atgcatgcat ctttttcgcc ctgaaaatcg cgggaaacca agtgtctttc 2892061 aaggattcat tctcaagatt cggagcattt cttattcctt ttacggctat tttgattctt 2892121 gcccttttct tctttttatt acatacagac atttgcttta ccatattagc cgttggttta 2892181 atcggtgcat tcttcgccat tcctcctgcg atgctgagca gttaccagca ttcatataaa 2892241 gggaaggttg atttcattta ctcaacgatt gtgatttatc tgatcatctg cgttacattt 2892301 cagcttatta tcgaacacta tgtcaaagaa attttccgtt atatgctctt ttaaaaacaa 2892361 ccccatcacc tgctggtgat ggggttgttt tattgaatag acgttaagta aattcttccg 2892421 ttcttcacta cgccggtgta ggtccagtta tatgttctga gctttggact gccgcctgat 2892481 tttgtgatat agaattcttc atacgtctta atcgtgatag ccgacccatt ttggctccag 2892541 cttttcactt catagttatt aaagtcttct gttgtcccct ctttatttaa tttcgacacg 2892601 agatgctgct ggtcggaata aagggaactg cctttttcaa ggctgtcttc catcagtgag 2892661 aaattatttt gattcacggc atctgcctga ctttgcagat aactgcccat aaataatgtc 2892721 acttgttcat ctgtaacatc gccgcttgca gagctttcac tgcctttgtt tttcgagcca 2892781 gcccaggcgg aagtgtatgt ctctggttta tcatttttga ttttctttat atttgtgcct 2892841 gcagattcga atgttgattc tgcatcttcg aaaatccact ttttctgttt tttatcatat 2892901 gaaagaagat attcataact cggactgtcg tcagtcattt cagactttgt atagtcgtta 2892961 tacgaagaag actggtgaag ttcttttcct gttaccgata cctgccacgt tccgtcgttt 2893021 ttctgagaga gggcaaatgt gtccaggtca aaatcagttt ccaagtatct atcttttaag 2893081 tatgaatccg cgcttttcat agaatcgacg gtgtccttcg tctccgcctt ccaattggca 2893141 cttgcctctg tcatctgggc tgtattccca tcagatagag ctttggagta ttgttttgtt 2893201 gttttgacaa ttgtgttcat aatctgttcc tgtgtatctt gatcaggaat taacgttaac 2893261 tccatttctt tatcatcgat cggaacgccg gcagtttttg tttttcccca cggaaattct 2893321 gcctcgactg aagctgtcat tgatccatct gtcagcagcg gaccatatgt tacggatttg 2893381 aacggatctt tatgaattga tttaccgtta atcagcaaat ctcccttccc gctcttgatg 2893441 tcattcgcta agctgaatgt cacatcgtct gcttccaatg agagatcaac acgaaagctg 2893501 ctatcgccaa tcgcctgaat gtcttccttt ttcacaaggt caacgacatc gtttttcagt 2893561 ttggctgaga ctgtatattc gccgggaatg tacggaccaa gggtttgtgc ttgatctgct 2893621 ttctttacag atccggcttc ctctttattg acatatagat cggtattttt ataattgctg 2893681 ctcacttcaa aataaacagg tgctaccttt aagtcataat ggtcaaatac cagcaggctt 2893741 ttcccgtctt tttccgcata tacgatatcc ttctgggctg tttcatcacg cagcgatgca 2893801 aaaagttcat cttttttgtc tggatgatcc ttcaaatatg taagaaacgg ttttacatta 2893861 tttttagtga gtttaagatt gtcatttacc ggtgtaagca gagtcgcgat ttggtcctga 2893921 tccccatcat ttacggcctg ttcaaacttg tctactaacc tatcctttga agtaaaatac 2893981 gctccggttt tatatgcggc gaataatata acgcacgccg cggcaatgct gctccataaa 2894041 atgatggttt tcttagggat cggttttcgc ggagcctgcc tcgtttctgc agtgctagct 2894101 gtttcttgat ttgcctgttt gctgccccct ccgatcgggg tgccgcattg tttacaaaac 2894161 ttggctcctt cattattctg ggagccgcaa ttcttacaaa ataacatgac tttcctccta 2894221 ttctactaat ttgataacat ttactgcttt tcatatttta taataaaaca gaatgaaatt 2894281 gggaacgaat gaaaaaatta aatgtctatc agactaaaaa ggtggaatga atatgcaaaa 2894341 gctcaggatt gaattaggag aagaaacaaa tgacgaatta tatgatctat tgctgctcgc 2894401 cgatccatcg aaagacattg tagatgaata tcttgagagg ggagaatgtt acacagcttg 2894461 ggccggtgat gagcttgcag gggtttatgt attgctaaaa acaaggccgc aaacagttga 2894521 aattgtaaat attgcggtaa aagaatctct tcagaagaaa ggctttggca aacagcttgt 2894581 acttgacgcc atcgaaaaag cgaagaagct gggggcggac acgattgaaa tcggaacggg 2894641 gaattcgagc attcatcagc tttccctcta tcaaaaatgc ggattccgca ttcaggcgat 2894701 cgaccacgat ttctttctca gacattatga tgaggacatt tttgaaaacg ggattcaatg 2894761 ccgcgatatg gtaaggcttt atttggatct ctgaaagcat aaaaaagccg ccgagagaaa 2894821 atcccggcgg tctttttatt acttgtttaa gttgtagaaa gagttgatac cgtggtattg 2894881 agcagtttca gccaactgat cttcgatgcg aagaagctgg ttgtatttcg caacacggtc 2894941 cgtacgagac ggagcacctg ttttgatttg tcctgcgttt gttgccacag cgatgtcagc 2895001 gattgtgctg tcttcagttt caccagaacg gtgagagata acagctgtgt agcctgcgcg 2895061 tttcgccatt tcgatcgcat cgaatgtttc agtcaatgta ccgatttggt ttactttgat 2895121 caggatagag ttgcctacgc cgtttttaat accttcagaa agttttttcg tgtttgtaac 2895181 gaagaggtcg tcaccaacaa gctgaacttt tttgccaaga cgctcagtaa gaagcttgtg 2895241 gccttcccag tcgttttcgt caagtccgtc ttcgatcgag atgattgggt atttagaaac 2895301 aagctcttca taccagtcaa ccatttcagc agatgttttc acaacgcctt cgccagacag 2895361 atggtatttg ccgtcttctt tgttgtagaa ctcagaagat gcagcatcca tagcaagttt 2895421 aacttcttcg ccaggtttga agccggcttt ttcgattgct tcaacgattg tttgaagcgc 2895481 ttcttcgtta gaaccaaggt ttggagcgaa tccgccttcg tcacctacag cagtgtttaa 2895541 gccttttgcg cttaatactg atttcaggct gtggaagatt tgagcgccca tgcgaagtgc 2895601 ttcacggaag ttaggagcac ctacaggcat gatcatgaat tcttgaatat ccacgttgtt 2895661 atcagcatgc tctccgccgt ttacgatgtt catcatcggt acaggaagcg tttttgagtt 2895721 gaatcctcca aggtattggt aaagaggaat ctgtaagaaa tcagcagcag cacgcgcaca 2895781 agccatagat acgccaagga ttgcgttcgc accaagtttg cctttgtttt cagtaccgtc 2895841 aagctcgatt aaaagctgat cgattgcgtt ttgttcagtt acatcaaagc caagaagctc 2895901 tggagcaatg atttcgttta cgttgttaac agctgttaac acgccttttc caaggtaacg 2895961 gtctttgtcg ccgtcacgaa gctcaaccgc ttcgtattca cctgtagaag ctccgcttgg 2896021 cactaatgcg cggccgaaag ctcctgtttc tgtatatact tcaacttcaa ctgttgggtt 2896081 gccgcgggag tctaatactt cgcgtgcata aacatcaaca atgtatggca tgagttttgt 2896141 ctctcctttt gattttcaaa ttatttttga attaaagatg ttcctgtcat ttctttcggt 2896201 ttttcaacac caagaaggtc taataacgtt ggtgcaaggt cgcctaggat tccgccttca 2896261 cgcagcgtaa tgccttcttt cgttacaatc acagggactg ggtttgttgt atgcgcagtg 2896321 tgcggttcgc ctgattctgt aatcagaatg tcagcattac cgtgatcagc ggtaatgata 2896381 gcgtgtccgc ctttagcaag gatcgcgtca acgacttcgc ccaagcattc gtccactgct 2896441 tcaattgctt taattgttgg ttcaaccatt ccggagtggc cgaccatatc agggtttgcg 2896501 aagttaagaa tgatcgcgtc atgcttgtca gcttcaattt ctttgacaag cgcgtctttc 2896561 acttcatacg cactcatctc aggcttcaag tcatacgttg caactttagg cgagttgatg 2896621 agaatacgct cttcacccgg gaattcagct tcacggccgc cgctcataaa gaacgtgacg 2896681 tgcggatact tttcagtttc tgcaattcga agctgtttta acccgtgctg agataatact 2896741 tctccgactg tgttatcaag atttatcggt ttaaacgcta catagccgtc aactgtttca 2896801 ctgaagtgag tcaggcagac gaaatacagg ttctttggat aattctcgcc gcggtcgaag 2896861 tcacggaagt ctttgtttgt gaacgtgttg gaaatctgga tggcgcggtc cggtctgaaa 2896921 ttatagaaaa tcacagaatc gccgtcttgg attttcgcaa caggctcacc gttttctttt 2896981 gtgatgacag atggaatcac gaattcatcg tagataccat ttgcatatga atcatcaaca 2897041 acatccaggg cgctgcggta agatgggcct tcgccgtacg ccattgcgcg gtacgctttt 2897101 tctacacggt cccagcgttt gtcgcggtcc atagagtagt aacgtccgga aatgctggcg 2897161 atttcaccta caccgatttc cttgatttga tcgttcaact ggttgatgta cgttttcgct 2897221 gtctgcggac ctacatcacg gccgtcaagg aagccatgga tataaacctt tgtcagccct 2897281 tcttttttcg caagctttaa cagtgcgaat aaatgattga tatggctgtg cacgcctccg 2897341 tcagataaaa gaccgaacag gtgcaaggct ttgttgtttt ctttcgcgtt gctgatcgcg 2897401 tcaaggaatg tttgattgcg ttcgaactct ccttcacgaa tggcaacatt tacgcgtgtt 2897461 aagctttggt acacaatacg tcccgcaccg atatttaagt gacctacttc ggagttcccc 2897521 atttgccctt caggaagacc tacagcctcg cctgaagcag tcaaagtttg atgaggatac 2897581 tggttccaat agcggtcaaa attcggtttt ttcgctaaag cgactgcgtt ccctactgtt 2897641 tcgttacgta atccgaaccc atcaagaatg atgagtgcag ctggtttttt actcatattg 2897701 accttcctcc aataattgaa cgaatgactg tggctcaagg ctcgcgccgc cgaccaaagc 2897761 accgtcaata tcggactctg ccatatattc tttaatgttt gcaggcttta cgcttccgcc 2897821 atattggatg cgaagcttgt ctgcagcttc ttggctgaag ctttcagcga cggttttacg 2897881 gatatgcgca cacacgtcat tcgcatcttt cgctgtagaa gatttgcctg ttccgattgc 2897941 ccagattggc tcatacgcaa taacagaagc agcaacttgt tcttcagaaa gaccagcaag 2898001 gccttttttc acttggtcag caacaagatc atttgttttg ccggcttcac gctcttcaag 2898061 cgtttcacct acacagatga tcggcacaat gccgtgtttg aaagctgcgt gtgctttttt 2898121 gttaactgtt tcatcagttt cagcgaacat ttcacggcgc tcagagtggc cgatgacgca 2898181 gtagtcaacg ccaaggtctt tcagagcaac cgggctgatt tcgcctgtga acgcgccgct 2898241 ttcttcgaag tgcatgtttt gagcgccgac ttttaggtca gtgcctttca cagcagaagc 2898301 aagcttttct aagaaaagcg ctggcgcgca aacaacagct tcagctttgt ctgctgctgg 2898361 aatggaagat ttcacttctt caacgaagct gacagcttcg ccgagtgttt tgttcatttt 2898421 ccagttaccg gcgataattg gttttctcat ctgttccact tccttatagc agttttgaga 2898481 ttatttatcg ttcagtgcag ctacccctgg aagctctttg ccttccataa actcaaggga 2898541 tgcgccgccg cctgttgaga tgtggctcat tttgtcagca aggccgaatt tttcaaccgc 2898601 tgccgcagag tctcctccgc cgatgacaga gtatgtatct ttcgcctctg ccaatgcttc 2898661 cgcaaccgct tttgttcctt gagcgaacaa gtcgatttcg aatacgccca ttggtccgtt 2898721 ccacacgaca agtttgctgt ttttgatgac gtcagcatac gtttcgcgtg ttttcgtacc 2898781 aatgtcgatt gcttctaaat cactagggat ttcagagatc ggcacaattt tcacgtttgc 2898841 atcgttagag aaatcatctg caacgagtac atcttcaggc atgtagaagt taacgccttt 2898901 ttctttagcg cggtccataa atgatttcgc aagctcgatt ttatcctctt caagaagaga 2898961 tttcccgact tcatagccaa gcgcttttac gaaagtataa gcaagacctc cgccgatgat 2899021 caggttgtct actttatcaa gaagactttc gattacaccg attttgtctt ttactttcgc 2899081 tccgccgatg atcgctgtga acgggcggtc aggattggaa accgcttttc caagtacatc 2899141 aagctctttt tccattaaga aacctgcaac tgctggcaga tgctcggcaa ttccagctgt 2899201 agatgcgtga gcacggtggg cagcaccgaa tgcgtcattt acatatacat ctgcaagctc 2899261 agcaaatgct tttgcaagct caggatcatt tttctcttca ccaggataga aacgtacgtt 2899321 ttccaataca agaacgtctc cgtccttcat ctcagaaatt tgtgctttta cagcatcgcc 2899381 gtatgcttca tccgcttttt tcacttcttt gccaagcagt tcgccgagac gtgcagcgac 2899441 aggagttaaa cgaagctcct caaccacttc gcctttcggg cggcctaagt ggctcgcaag 2899501 aaggactttt gcgccttggt ctgcaaggtg tttgattgtt ggaagcgcag cacggatacg 2899561 tgtatcgtct gttacttccc cgtctttcat tggaacgtta aagtcaacgc ggcagaatac 2899621 aactttgcct tttacgtcga tgtctttgag agttttttta ttcatgccta ggagatcctc 2899681 cttcaaaatg gtttgcatac agcacgaaaa acgtgaaacc gtctgttcaa gcgataactc 2899741 cgctagggca gatcgcagtc tttttcggca cagggcagtt cgtctaaaag ccagggcagc 2899801 ggccttaggc gaaagcgccg gcaaagctgc ttaaaacgcg gtcgtttctc tatcacagag 2899861 cgttttctga aagccggtct tcatggaaaa agggaaaggg agtccgtccc cttcccttgt 2899921 ccgctttcat tatagcgctt ctattcgaaa gaaccaagtc aggtcctttt tcagctataa 2899981 attaaagacc tttttttgcg atgtaagctg caaggtcaac aacgcggtta gagtagccgc 2900041 tttcgttatc gtaccaagag attactttta ccatgctgcc ttccataacc attgtagaaa 2900101 gagcatcgat tgtagaagag tttttgtttc cgttgtagtc gccagaaact aatggctctt 2900161 cgctgtagcc aaggattcct ttaaggtcgc cttcagccgc ttctttaaga gctgcgttta 2900221 cttcttcagc tgttacttct tggttcagtt cagcaaccaa gtcaactaga gaaacgtttg 2900281 gagttggaac acgcattgct ccaccgttca gtttgccttt tagttcagga agaactagag 2900341 aaactgcttt agcagcacca gttgatgttg ggatgatgtt ttcagctgct gcacgcgcac 2900401 gacggtagtc tttgtgcgga agatcaagga tttgctgatc gtttgtgtaa gagtgaacag 2900461 ttgtcatcat accgcgtttg atgccgaatt tatcgttaag tacttttgca aacggcgcaa 2900521 ggcagtttgt tgtgcaagat gcgttagaga taacatcgtg gttagccgca tcgtatttat 2900581 cttcgttaac acccataacg attgtgatat cttcttcgtt agcaggagca gagatgatta 2900641 cttttttcgc gccagcttct aagtgtttcg cagcgtctgc gcgttttgtg aagaaaccag 2900701 tagattcaac tacgatttca acgccttgtt tgccccagct aagtttagca ggatcgcgtt 2900761 ctgcagaaac ttcaattgtt ttgccgttaa caacaaggtt gttaccgtca actgaaactt 2900821 cagcgtctaa ttttccgtgt acagaatcat attgtaaaag gtgagccagc atgttagcat 2900881 ctgttaaatc gttaaccgct actacctcaa cttcaggatt gtttaatgct gcgcggaata 2900941 cgttacgtcc aatacgacca aaaccgttaa taccgacttt tactgccatg attgtttcct 2901001 cctttaaata agtgagagat atttatattg agggattatt catcccttaa taacttcttt 2901061 gcggctcctt cgtctgtgac gagaaccgtg ttgcgtggct ttttaaagta agcctcgatc 2901121 gcttcggctt ttgatgatcc gcccgctacc gcaataatat cggggatggc gtctatgtca 2901181 tccagctgca ttccgacaga atgcactttg tgaaccactt cgccgtccgc gttaaaatag 2901241 tagccgaacg cttccgtcac cgcgtcgtta tcatctattt tctttaaatc ttctaaaggc 2901301 gtgtttctgc gctgagccat agttttagct tcgccgattc cgtgaaccag catactcgct 2901361 gatttaatgg tgttcagcac ctctttgaca gaaggctctt caataataga tgaataggcg 2901421 ccttgtgaca gctgtcccgg aacaaacaaa agccggtaag tgcctgaagc cttctccgcc 2901481 atatgcgcgc atatggtgtt cgcctggttt ttcacgtctt cgcctaaacc gcctcttgca 2901541 ggcacaaaca aaagctcgcg gtttttagaa tccggcgtca tcatttcggc gacagcttca 2901601 attgtcgtac cgccagttac agcgacgata tttttgcctg aaaatctttt tttcatacat 2901661 gcgacagccg ctcttcccat ttcttttttg acccatgggg attgatcgct gtctccggat 2901721 acgataatgg catcctttag atttaaacgt tcttttaatg tcttttccaa aagagtcaaa 2901781 cctaaaacat ctttcatcgt atcttccaaa acagaaagca gttcatagcc ctcttctgtc 2901841 aatgtcatgc cgtttgtctt aatatcgacc aggttctgtt cctttaaaaa ctgaacctcg 2901901 cccctcagca cacgctcgct gattccgaga ctggcagaca ggcttcttcg cccgatgggt 2901961 tctgtcagcc tgatatactg caagatttca aacctctttt gcataacgag cagaagatca 2902021 ggcaataatt ttttttgagc ttgtattaac tggttcatga ctcaaacgtt ccttcctttt 2902081 ttgctggaca ttatatgtcc cgctatgaca aaaaacgtcc cgtcatagcc aaaaaaaatc 2902141 atttctgctt tctttaatta ttttaacagg gtggaattgt ttattcaact gttaagagcc 2902201 aattcatcga caatattcgc agagttttca tgccgcgtcg ttttatccag caatatttta 2902261 tcctatatat ctttatctta tacagaaagc gccaaatggt gcatcccaat ataaacagcc 2902321 cttcccgtag aaagggctgt ttcattaaag cgttttcatt ttatccaaag cttttcaatt 2902381 tcctcgagcg atttgttctt cgtttctgga cagatcgtaa cgacaaacag gaaacaaagg 2902441 atgttaatca ccgcaaagat ccaaaatgta taggcgagcc cgaaagaatc gatcatcatt 2902501 ggcacaaact gtccgatcgc ccagtttgct ccccataaaa agatggtcgc aatgcccgcg 2902561 gcccgcgcac gcagatggtt cgggaagatt tcagaaatca taatccatgt gatcggtccg 2902621 accgagacac agaaagcagc gacaaaacct aatataagga cgatcatcat gatcccgctt 2902681 gttaactcaa aataaaacga cgtcccgatt aaaatcataa aaatagccat aaaagcagaa 2902741 ccgatggaca tcagtttttt tcgtccgact ttatcaatca gcaacaccgc aataacggta 2902801 aaaataactt ctacaacccc gacgatacaa gtcgtcacaa atccggcgtt ttgcccgaat 2902861 cccatcattt taaagatttc cggcccgtag taagtaatcg cgttcatgcc gatgacttgg 2902921 ttaaacagcg ccagcaggat tccaatgaca agcgcctttc tgagacccgg cttaaacagc 2902981 tgggagagcg accccatttg ttctattttt aaagagttct caatgttctt taattcttct 2903041 tttgcaacag tttctccatt aatacgtgtc aggatcttta aagcttcatt tgttttgccc 2903101 gctttcgcca gccatctcgg actttccggg acgacgagca ggacaaggaa aaaaatgacg 2903161 gatggcacca ttccataagc aagcatccat ctccagccgg tgtgcacgcc ccattcgtat 2903221 gttccggacc gctgcacagc tagattaata aagtatgttg cggaaatacc cagtatcgta 2903281 aagagctgat ataacgaaga taaacttccg cgtatagcgg gcggtgccgc ttctgtaata 2903341 tacgtaacag agagcgatga gcccatcccg attcccagcc ccccgataat ccttgcaatg 2903401 attaaggtgg acacgtcttg agaaagcgct gaaacgattg ctgatatcgc aaataacaaa 2903461 gcggctgtca ttaaaatttt tctccggccg aatctgtcac ttaaaaatcc ggatatcccg 2903521 acgcccacaa ctcctccaat cataatgctt gaaatgacaa gtccctccat aaacggactc 2903581 aggctgtata aatctttcag aaaaccgatg gcgccagaaa tcactgccgt gtcatagcca 2903641 tacaataagc cgccaagccc cgccgcacat gagatcaaaa tgacaaatcc cattgaatgg 2903701 cttcttgtta caggaacatt tggttctaat tgagttggag tattcttcat ttccctgccc 2903761 tcccgaatgt tgagtaaagc gttttcattt aaaccttcaa ttgtacgtac ttatattaaa 2903821 atttaacgaa aattacattt aattagtacg tacaaatata gaataatctt gtttgcattt 2903881 tctgtcaatg ttttcttaca aagaacgctg tgatatactg aaatttgtcc gtatacattt 2903941 tggaggaatg gatatgttac caaaatacgc gcaagtaaaa gaagaaatca gttcttggat 2904001 taatcaaggc aaaatactgc ccgatcaaaa aatccctacc gaaaacgaat taatgcagca 2904061 attcggcgtc agccggcata ccatccgcaa agcgatcgga gacctcgtat cacaaggtct 2904121 gctgtacagc gtgcaaggcg gaggcacctt tgtcgcttca cgctctgcta agtcagcgct 2904181 gcattccaat aaaacgatcg gtgttttgac aacttacata tcagactata ttttcccgag 2904241 catcatcaga ggaatcgagt cctatttaag cgagcagggg tattctatgc ttttgacaag 2904301 cacaaacaac aacccggaca atgaaagaag aggcttagaa aacctgctgt cccagcatat 2904361 tgacggactc atcgtagaac cgacaaaaag cgcccttcaa accccaaaca tcggctatta 2904421 tctgaacttg gagaaaaacg gcattccttt tgcgatgatt aacgcgtcat atgccgagct 2904481 tgccgcgcca agttttacct tggatgatgt gaaaggcggg atgatggcgg cggagcattt 2904541 gctttctctc ggccacacgc atatgatggg tatttttaaa gctgatgaca cacaaggcgt 2904601 gaaacggatg aacggattta tacaggcgca ccgggagcgt gagttgtttc cttctccgga 2904661 tatgatcgtg acatttacaa cggaagaaaa agaatcaaaa cttctggaga aagtaaaagc 2904721 cacactggag aaaaacagca agcacatgcc gacagccatt ctttgttata acgatgaaat 2904781 tgcgctgaag gtgattgata tgctgaggga gatggatctt aaagtgccgg aggatatgtc 2904841 tattgtcggg tacgatgatt cacatttcgc ccaaatctca gaagtgaaac taacctctgt 2904901 caaacatccg aaatcagtgc ttggaaaagc agccgccaaa tatgtcattg actgcttaga 2904961 gcataaaaag ccgaagcaag aggatgtcat atttgagcct gagttgatca ttcgccagtc 2905021 cgcacgaaaa ctgaatgaat aaaaaaagca atgtatgggt ctccccgcta cattgctttt 2905081 tttatagctg ttatctgttt ttccaaacgt cagcgatgat ttcaaacgaa cgcattctgt 2905141 ctgcgtgttc aaaggtttct gagttaacca taatttcgtc agcctgtgtc gttttgacga 2905201 aatcttcaag cttcgccttc acttcttccg gacctccgac aatcgtggag ctcagctgct 2905261 cattgaccat cgctttttca tacgggctcc agatttggtc catatcctca acaggcggtt 2905321 taagctggtt aggcgtaccg cggacaagat caagaaacct ttgataatgg gaagtcgcaa 2905381 ggtgctgcgc tttctcgttt gtatctgccg cgataatggt gacaccgacc atcgcatacg 2905441 gttcgtcgag cacgtctgac ggcgtgaagg aattgcggta cagctccaaa gcgggaaccg 2905501 tattcgccgg tgagaaatgg gccgcgaacg caaacggaag accaagttcg ccagccagac 2905561 gggcgctgaa gccgcttgag cccagcagcc aaatcggcac atctatgccc tctccgggaa 2905621 tggcgcgaac ttgattgcgc acatttcctg acggtttaaa ataattgcgc agttcctcta 2905681 attgttctgg aaaatcctcc ccgctgttga tgtttctgcg gagcgctctg gctgtcaatt 2905741 ggtctgttcc cggcgcacgt ccaagcccca gatcaatccg cccgggatac agtgtttcca 2905801 gtgtgccgaa ttgttcagca atgactaatg aagagtggtt ggggagcata atgccgccgg 2905861 aaccgacgcg gattttcttc gtgcctccgg caatatggcc aatcaaaact gcggtggcag 2905921 agcttgcaac accttctata ttatgatgtt cagcaagcca gtaacggtga tagccccatt 2905981 cctctgcccg gcgcgccaag tccatgctgt ttcggaatga ttctgcaatc gttcctccct 2906041 gaacaaccgg agataaattc aagacagaaa gcaaggtatc tttgcgttgg ttgttagaca 2906101 tattgttctc ctttgcaaat gtgttatcag taaacagccc aaagctgtca ggtcatgatt 2906161 gaaagaactt ctatcacacc ataacacaac tgcattcagg aataaaagaa tttgattcga 2906221 tgaaattcga acaatataaa acgaacggtt tggaacatta ttctgctcca aacaactcct 2906281 tagccatctc aataaagagc ttagccgcca gagaagcctc ctttagcgac ggaacagcaa 2906341 gctgcacatc acggtatacc tgcgggtcca attccctggt caccacatgc tctggcagcg 2906401 gcatccccga catggacatt tctgataaaa tggccaggcc caggccttct ctgatcatac 2906461 tgatcgaggt gttgatgtta tagaccgtga aagctgggtg cagcgtagca cccgcctgcc 2906521 tgaacatatc gataaatggt gattcatagc cgccgtcaca gacgatcatc ggttcatggt 2906581 caagatcttt cagcgtaatg gctgaatgac tggcaagcgg gtgatcgtcc ctgagcacga 2906641 cagccatttt gtcttttttc aaatgaatgt actccatctc ctctgttgga tacagaagaa 2906701 tcccaacatc tatcatccgc gtatgaagcc actccttgac ttcatttaca gttccctcgt 2906761 gcagcacgag ctcaagtttc ggatattttt gtttaaattc actgatcagc ttcggcataa 2906821 aataagccga ggcagttgag aatgtgccga tatggatcgt tcccagttca agcccttttt 2906881 ccgctgctgc tacctgctca actttttcaa tgccttttaa gacttctctg atgtgtacta 2906941 agatctgttt tcccgtatcc gtcagcatca ggccattgcg gcggtcacga atgatcagct 2907001 ttacatcaag ctcagcttcg atcgcagaaa tcgcatggct gacagccggc tgtgtcatgt 2907061 tcagcgcctg acccgctttt gtaaagcttc ccgtttcagc tattttcaca aaaaccttta 2907121 attgagtaat ggtcataaca atttacttat gctccttata aaaaagattc attttattta 2907181 tcttatgttc taccgtatca tatgatggaa aagttctaca aggagtgaat gaacaatgaa 2907241 gcagctccca aaaacgcgga cagctctcct gctcgcattt ctcgtcatca tgtggggcgt 2907301 caattggccg ctgtccaaag ccgcgctcgc ctattctccg ccattattgt tcgcgggcat 2907361 ccgaacgctg atcggcgggc ttttattagt catagtcgca ctgccgcgta ttcataaatt 2907421 acgcttaaaa gaaacgtggc cgatttatct tgtttctgct cttttaaata ttacattatt 2907481 ctacggcctg caaacgatcg ggctgaatta tcttccggcc ggcctgtttt ctgcaatcgt 2907541 cttcttccag cctgttctga tgggtgtatt ttcttggctg tggctcggcg aatccatgtt 2907601 tgtaatgaaa gtgattggcc tcatcctcgg ttttgcggga gtagccgtca ttagtgctgc 2907661 gggctttggc gggcatattt ctgtcattgg ggttctgctg gctctcggct ccgcagtcag 2907721 ctgggcgctc gggacagtat atatgaaaaa aacaggcagc cgcgtcgatt ccatctggat 2907781 ggtcgctctg cagctgacga tcggaagcgt gtttctgctt atctccggct tttggacaga 2907841 aagcttttcg gcgatccaat ggacagctcc gtttattacg agcctgctgt tcatctccgt 2907901 attcgttatc gcactcggct ggcttgtctt ttttacgctt gtcggttcag gagaagcaag 2907961 caaggtcgca tcttatactt ttttgattcc gctcatatca atcgtggcca gctccatttt 2908021 cctgcatgaa ccgctcaccc ttagcctctt ggcagggctg ctgctgattg tcacgagcat 2908081 ctgtctcgtg aatacaaaat caaaagcgca gaaagctgcg gcgattggta taaacgagaa 2908141 agctgcacaa taataaaaac cctcttgccg gatgcggcaa gagggtttct tatttactga 2908201 tgcttgcgtc ctttgaccaa atatgcaact gtaatcaaaa ggtagatcgc cgcagtaatg 2908261 ccggtaatga caattgatgt tgtcatgatg accccgatca gaatggcgag taatgccaca 2908321 atcgcaaacc atgtcgtgta cgggaaccat tttacataat aggccggtgt ttccgtttgc 2908381 tgttttctcg attttaaatg agcgaatccg atgatcagcc aaatgaataa aacggtatat 2908441 cccaatgatc ccattaaata attaaatgtt tggcttcctg cgaacagaga aatcaatacg 2908501 ccaatataga gagaagaagt gcacatcaga atcgcaaaca tcggtacgtt tttcgatgaa 2908561 agcttcgaga agacctttgg aagccttccg tcacttgcct gtgtatacaa aatgcgtgat 2908621 gatccgtata aacctgaatt catagaagaa atgatcgcca gcaggatgac tgcattcatg 2908681 atatgatccg cgcccggaat gcctaccatt ttaaagacca tcacgaaagg actttccgga 2908741 acggaattga cttggttcca tggaatcagg ctgacgatga tgaaaaacgg cagcaggtaa 2908801 aacgcgacaa tccgtgtcag tgtgctgcgg acagctttcg ggacaacctt ttccggattt 2908861 tttgtctctg caagcgttac accgataatt tctgtaccgc cgtaagagta gatgacgaca 2908921 agcatcgccg tgatcagccc tgtgccgccg tgcgggaaaa atccgccgtg gtctgtcagg 2908981 ttggaaaatc cggatgctgt atgatcaccg aatgatacaa ataagagcag caatcccaga 2909041 ataataaaga taataataac ggtaatcttg atcattgcca gccaatattc agtttcggcg 2909101 aagattttaa cagaaagcaa gtttacaatc gtgacgataa gagaaattcc taatgccaac 2909161 acccagatcg ggcagcccgg cagccaatat tgaatgaaaa tcgcagctac aacagcttca 2909221 gccgcaatgt taagcaccca cattttccag tagatccagt ccaaaaagta agcagcgtaa 2909281 tttcccaata cctgctggac aagatcacgg aaggttctgg cgttacggtt tcgaacagcc 2909341 atttccgcca gcccctgcat aataaacagc aaaataatcc cgccgagcag gtatgcgata 2909401 atgacagatg gccctgccac atcgatcgct gagctgctcc ccttaaataa acctgcgccg 2909461 attgctccgc ccagcgccat catcataata tggcgggacg tcatcgtgcg ttttaacgtt 2909521 tgattgtcgt ttttcatcct cttctacctc tccttctcgt tttcaaaaac aaaaaagccc 2909581 gccgtctcct acctaatcta atagataaag agacgacgag ccttcggctg accgcggtac 2909641 cactcttgtt gattcttcat gaagaatcct gcttttgacc tgtaacgaag gttagccgtt 2909701 aaaacatagg gaatattcaa tctattccgt tccgtcttac cactcccggg cgagttcaaa 2909761 gaagaatcag gctgcgtcgc accaccccgc agctctctgt tctgatcact ttcttttact 2909821 gctcccaatc tatgtgtttt agttttctga aaaactcaaa ttttatgatc tgaatatatt 2909881 aacataatat acgtgcttct cttttaactg tcaataactt cagagaaaaa agaaactgtt 2909941 attttgtccc ttttcgaatg gctttccaaa aggattctga ctcgtttcct aatgcgtaaa 2910001 ctgaaacacc tgctatttta tattgctttg ccagatggct tttcgtttga acggtttttt 2910061 cgttttcata ccacacgaca tgtttatgct tctttttgtc aacataagaa aacgtcatcg 2910121 agcctgattt tttgttgaat gccggctttg ctttttgttt tttgatgagg gatttgagct 2910181 cattccattc ccttattgtg ctggtacttc cgtcttttac atcccagtca tagccgtacg 2910241 cagggattcc catgatgact ttattggctt tgatcttttt gactgaaaac tgcagagagc 2910301 ttttgatcca gtttgtgctt gccactgacc ccggctcacc ccaaatgccg tgttcatcgt 2910361 aggtcatgac ttgtacgaag tcggcatatt tgccgatttt cgcataatca tacggccagc 2910421 tccagtcatc atttttatca tcggcgcttt tggccggaac ggataccatt gttttaatat 2910481 gtttcttatt caaagcctgt gagacatatt gaatgaagtt cgagtatgca gcgcggtctt 2910541 ctggatttac tgcttcaaaa tcgatattga ttccgtaata tgagtgcttt ttggccagtg 2910601 taattaactg atctgtgaat cgttttttcg ctgttttatt gctcatgacc cgactcgcta 2910661 aatctccgtc aaaatcataa atggcatcat tatagtttga aatgacagcc catgtcttga 2910721 tttttttctt tttcgcatat gtcagctgct tagttggggc atcgccaatg atttgtccgt 2910781 ttttttcaaa cgcaaatgta tcggttgcga tggcattcat gtatgtatga tatttcgtaa 2910841 gagaattgta tgaagccgta tccccagtcg tgtagcctac tgtcataccg gctgccttcg 2910901 cttctccttt tgtatacata aacagaacaa tcgcaatcgc cagtgaaacc gctatgatca 2910961 gccatttttt catcgcattt cctcctgtat caagtcatac tcttctcatc ggccaaaaaa 2911021 ttggaagttg aagttttttc aagcaaaaag cccggcatat gcctgccggg cttcctgagt 2911081 tcagcggtca gagacgagaa tatatgctgc ctttactggt ccatgcaccc ccacaactaa 2911141 atccatttca atgtcggctg agttactcgg tccggtaatg tagttgatac atgaaggaac 2911201 agtgacaccg ttcgcaatgt tttggcggat gatatcactg gcttgtgtca ttctcggtac 2911261 aatgcttgat ttcggcacga tcgcaatata agtcgttggc aaaaggctga cagagcggcc 2911321 gatgtctttt gaggagaaga ggacaaccgt ccccgactca gccaatgtaa tttcgctgaa 2911381 tgtaatccct acattggctt gctccgcttt tttaatattt tcctcgcctt tgtcagcatc 2911441 ccactcccag accggcgttc cttcactcgg ccagtccttg gtgagcaggc ttttcagtcc 2911501 gtattcttca aagcgggggt ccttcggaat gatgacaggg cctccagaaa agcggctgac 2911561 ttgctcgcgc agggcatcgt aaaggccggt tgaatccgtt tcaatcagct ctgtatggat 2911621 tttgacacaa tggtttttga gcactgtgac taagtcatcc gctgaataac cttcaagtgt 2911681 tttatattgc ggctgatgcg cccattcagg gactgccacg cctcctgttc ttcgttcacg 2911741 gcccaggctg gatgcgattc ggtttaaaaa gctctcttga ttctgaatgg ttcccttcgt 2911801 catcactgct cctccttcgt gcgttcactt gtttctctgt ccgcaaacca gtctctgaat 2911861 ctcgatttat gcggtgccgg gaagtcgcga atctgggtcc aatttttaag cgggccgggc 2911921 cctttcgaaa ttttttcgtc ctctgtaaaa ggcgtcatgg cggccggcgc ccattttgag 2911981 cccattttgt aaagcgataa ggaggatgcg ccaagtccga atgctttcat tgcaagcttt 2912041 tcactgatcg gcgccctgcc ttctttttcg acgatattct gacgatgctt gagtagcagc 2912101 tcatgaagcg ggattttgac cgggcaggct tctgaacaag cagcgcacag tgaagatgcg 2912161 tacggcagct ccttataatc gtcataaccg ccgagcaacg gtgataaaac agctccgatc 2912221 ggccccgagt agattgagcc gtatgaatgt ccgccgacat ggcggtacac aggacagaca 2912281 ttgatacagg cggcacagcg gatacattgc agcacagact ggaattccgt tccaaggata 2912341 ttggatcgtc cattatcaac gatgacaaga tggaattctt ccggaccgtc cacttcacct 2912401 tccagcttcg gacccgtcaa agctgtaata tagcttgtca gccgctgtcc gacagcactt 2912461 ctagtcagca tgctgactag cacttcaaat tcagaaaatg acgggacaat ccgctccatt 2912521 cccatgacgg taatttgtgt tttcggcaag gtgctcacaa gccgtccatt tccttcattg 2912581 gtcacaaggc tgacggaacc cgtgtcagcg atggcgaagt tacagccggt aatgccgata 2912641 tccgcttcca gaaacttttt ccggagaatg gcgcgcgcat gcatcaccag ctcttccggt 2912701 ttttctgtat gttgatagtc cagtctttct ttaaacacat cgcgtatctg ctctttattt 2912761 ttatgaagag cgggcgctac gatatgtgac ggcggatcgt gatcatcaat ctgcaaaata 2912821 tactcgccga gatcggtttc tacgacttca cagccttcct tctccagcac ctcattcaga 2912881 ttgatttcct ctgtgaccat tgatttagat ttcacaattt tcttcccgtt cttcttttga 2912941 atgacatccc gaatatagga agacgcctct tccgctgttt tcgcgaaata gacatgtccg 2913001 cctcttttcg ccacattttc ggcaagctgt ccgagataga aatcaaggtt ttcaaggaca 2913061 tgctgcctga tttcctctga taatgagcgc cactcctccc agtttcccag ttcttctgct 2913121 gcctctaggc gccgcgtccg cagacgctcc tgtgcacctg aaacagcgcc tctcataaat 2913181 tcattatcaa tcccctgtga tacccgctct ttaaaagcgt cagtaccgat tttcatcgcc 2913241 atgatccttt ccccctctga atccagtttt atctgctgtt gagcacttcg gcgatgtgca 2913301 tcactttgac attcttatct tttcggccaa gccgtccccc gatattcatc aaacagccgc 2913361 agtcagcacc gatcagcacc tctgctcccg tttcctccac acattcgact ttttcatcga 2913421 ccatctgctc agaaatctgc gccatcttga ctgagaacgt tcctccgaat ccgcagcagt 2913481 tatgtttgcc cggaagctct gtaaactgca ggcccttcac atggctcaac agcttcatcg 2913541 gctccttccg aacacccagc agcctagtca tatggcacga cgtatgtaag gtcgcttttg 2913601 tatgaagggt cgcgccgaca tcctctaccc caaggacgtt cacaataaaa tctgtcagtt 2913661 catacgtttt atccgccagc tttttcgctt tatcggccca tttcggatca tcctgaaaca 2913721 ggtgcggata ctcccggaac atcgttgtgc aggaacccga aggactgaca acatattcgg 2913781 aatcctgaaa cgtttcgatc atccgtttca ttgctttttt ggcgtcatgt acatagccgc 2913841 tgttgtaagc cggctgtccg cagcaaatct gcccttctgg aaaatcaacc tcgcacccaa 2913901 gccgctccag cagctcaacc gttgcttttc cgacatttgt ttgaaacata tcaacaagac 2913961 aagtgacaaa aagtgagact ttcatgatga acccctctct catccccaat atatgatcag 2914021 gtcatctgat gacctgagtt aaaataacta tatgaatatc gtacactatt ctgacaatgg 2914081 aaggaaagag ttttctaggg atattttcat ttgtggcata tcaaaaacac tcccgatctc 2914141 ccaggagtgc agtatatggt tagatccagc ccttttcctc agcgatgctg gcggcttctg 2914201 tccgattttt cgcattaagc ttttggatga tttctgagat atagtttcga actgtgcctt 2914261 gagataaata gagctccagc gtaatgtctt ttgttgtctt gcctaaagcc gcaagcctca 2914321 gaatttcttg ctctctaacg gttagcggat tttcgtctcg catcatatta aacgtcagct 2914381 cagggctgaa gacacgtttt ccctttacac attttcgaat ggcatcggcc agatcgtcaa 2914441 tttcaccgtc tttcagcaga tagccatgtg caccggcctt tacggcgcgt tcaaaatatc 2914501 cggggcgggc aaaggtggtt aaaataatga ccttgctgac gcagcctttt ttcattaatt 2914561 cctctgccac attcagcccg cttcgaaccg gcatttcaat gtccataatg catacatccg 2914621 gctccagctt caaaatagca tgtagcgcct cttccccgtt taatgcttgt ccgatgactg 2914681 tcatatcctc ttctaaatca agcaaagatc ccaaagcgcc taaaagcatt cgctggtcct 2914741 cagcaataaa cagacgaatc attcttttcg tcctccaatc attctgcttt tttaataagc 2914801 ggaatcgtca gtgccacaac cgttccgtta tggtctgaaa ccgttaatcc cccttcaatg 2914861 agcatgagcc gttcttccat tccccacagg ccattcccaa acattttctc cttcggcgct 2914921 ccctttccgt catcccgtat tacgatcctc attttgtcag caaattgaga aatggtgatg 2914981 gcacagtggg ttgctttgct gtgcttgata atgttagtca cggcttcccg catacacata 2915041 ctgataatat tttgagtgac gggagatatc actgaaaagt cgtcggctcc ttcgtattga 2915101 aaggtaatgt tccccgctct taatatgtgc tgaatgttta cgagctcctc tgttatcgtg 2915161 accgttctca tatcagaaac cagctctcga acttgcttga gtgcggagcg tgaactggtt 2915221 tccatttctt ttgcctcaag cttggtccgt tctggatcag atgcagccag ccgctgaatg 2915281 agctggcttt ttaatgtaag cagcgacagg gtgtggccaa gagtatcgtg aagatcacgg 2915341 gcgattcgaa cacgttcctc ccttttagag agttctttta tctgttcgtt ggcttgtgca 2915401 agcttagctt caagctcaat cctccgaaac atagaacgaa ttccgaatgg agaaatgagc 2915461 ataatgacga gaaacgggag aacagaaaaa agctcccgaa gcgagaccga attcgcgata 2915521 aattggtata ggcatggaaa aagcagtata aagattaaag cgcagaacgc acggttaaaa 2915581 ttcgttttct ctttgtaata accaacaaag tttgccggaa aaaaacctaa gtatatatag 2915641 gtgatattgt aaaacacact atacatcaaa ataaccgcca tttgcacgat aagccaatat 2915701 gtaaacgaag ctttgcccac gctgcagaat aactggcgat atgccgctac aaaaaggagc 2915761 agcataccat atccgatccc ctgtttgacc cctgattctt ttaataaaga gaggaacggc 2915821 ataatcgtat acaccagaaa gatataaggg aaaaacccga attccttcgg gaaaatagat 2915881 attgcctttt tcatgtatta caccgcttct tgttttcttc ttatatattt agatagtagc 2915941 atgaagagca tcatataagc gattaatatc agaatatttt tccaagtcgg actcccaccc 2916001 cggacaagtt cccacgctcc gctcccgaaa tgataagacg gaagccactg gccaatgctc 2916061 tgcatcatgt caggcatgac ctcaaacggc atccacatcc ctccgcctaa agccagcagc 2916121 atataaagca cattactgat tccggccgct gtttctactt ttctcatgag gccgattagt 2916181 gtgcctaatg ctaaaaaagg caatgcgcca aacaaaatcc acagtccgct catcatccat 2916241 tcaaacggtg acaaggcaat atcattgatg attgcgccga acagaaatat gacggtaatt 2916301 gataaaacgt gaatgacact ttggccgatc atctgagctg ataaatagat atgatccgga 2916361 agaggcgtaa ggcggataaa ggcggcccag ccttgtgacc gttcttgtac cattcggatg 2916421 ccaagcgtca tgatagagga acccatcacg ctgaagactg tcatcgacat caggtaatgg 2916481 gcttcccatg cacgttgatc agggacgttg gtattcacta catttgtaaa gaaataataa 2916541 aaggcaatcg gcatgatcag agaccaaagc acaaagtact tgttcctaag cacccttttc 2916601 atttcagcga tgctttgctt ttgcagcacg ttcactcaca tcgcctccct gttgccgtca 2916661 gccagctggc gaaatgcctc atcgagcgtt gcttgctcaa ttcgaatatc ccgtgcatgt 2916721 atgttttctt gaaagatcag cgccaacact ttgtctgtat ttgatgtctg gatgatggtt 2916781 ctctcatgct cgtggatcac tctctcgact tccgggtgac aagacagcct ttccaatgat 2916841 tcacttgaat gaagcgtaaa ggaaacagac tgtttttgaa ttcttgagcg gatttgcatt 2916901 ggtgagccgt ctgcaacaag ctgtccttca gtaaaaaata ggattcgctg tgcggcatca 2916961 tctgcttcct gtaaataatg agttgaaaaa ataatcgttt ttccttggtc cgacagtccg 2917021 tgaatggtct gccagaatcg gtgtcttgat gaagtgtcca tgccgactgt cggttcatca 2917081 agtataagca gctccgggtt cccggcaaga gccaaagcaa agctcaaacg gcgtttttgt 2917141 ccgccggata atttttctgc tcttgttttc aaatcttctt tggtgagtgc tgttaacgaa 2917201 acgagttctt tcatggacaa tggattcgga taatagctcc ggaagagttc aaggatttca 2917261 tccaccttaa ggcccggcat gacacttact tcctgaagca ttacacctat tttttcacga 2917321 acctgttgat catcgggaac ccggttaaat agtttgattt ctccctcact cggtttcagc 2917381 aatcctaata tcatcgagac gacggtcgtc ttccctgccc catttggccc gagaatggct 2917441 gcaatttctc ctttttcaat actgaagctg atgttgttta cagcggtttt tcgctggaaa 2917501 tgttttgtca cgttgcttac tgttactgct tctttcatca catgagcacc tcctgatcgt 2917561 ttacattgat tgtaaaatga cggagaagac gatgttagta tggggtgtca tgatgatgga 2917621 gtgacaaatg tcattttttt ctcaccccgg tgtctaggca atcctcctcc tgcatcttcc 2917681 aattcatcca tcttttctat ctcccatgtc ctctttcttt taaactgctg tgacattcat 2917741 agaaagatac actcttcaaa ccatccgagt gttatgatag aaatattgaa ctttatatta 2917801 ctttccggct gaaaggagcc aatcatgaac gaagcgattt tgtctagaaa tcatgtgaag 2917861 gtgaaaggca gcggcaaagc atctatcatg ttcgcacctg gttttggatg cgatcaaagc 2917921 gtgtggaatg ccgtggcacc tgcctttgaa gaagatcatc gggtgatttt atttgattac 2917981 gtcggttcgg gacattcaga tttgcgcgca tatgacctga atcgttacca gacacttgac 2918041 ggctatgccc aggatgttct tgatgtttgt gaagctttag atctgaagga aaccgtgttt 2918101 gtgggtcact ccgtcggggc cttgattggg atgcttgcat ccatccgccg cccggagctt 2918161 ttttcccatc tggtgatggt ggggccttct ccttgctatt tgaatgatcc gcctgagtat 2918221 tacggaggat ttgaagagga gcagctcctt ggcttgctgg agatgatgga gaaaaattat 2918281 atcggctggg cgactgtatt tgcggcaacc gttctgaatc agccagatcg gcctgaaatt 2918341 aaggaagagc ttgaaagccg tttttgttct actgatcctg tcattgcccg ccaattcgcg 2918401 aaagcggcgt ttttttctga tcaccgagag gatctttcga aggtaacggt tccctctctt 2918461 attctccaat gtgcagatga tatcatcgca cctgcaacag taggtaagta tatgcatcag 2918521 catctgcctt atagcagtct gaaacaaatg gaggctcgcg gacattgccc tcatatgagc 2918581 catccagatg agacgataca gctgatcggc gattatttaa aagcacacgt gtgatatagg 2918641 aacgaaaggg atagaggtga ccctcttaga tggacaaaca attgaatgat gcaccatgcg 2918701 gtttcctcgc tttgtcagaa gaggggtcga tcatagctgc caaccgcacc cttatcaaga 2918761 ttctggatta tgaaccggag caggttatcg gccagcacat gaatatgatg ttgaccattc 2918821 ccgcgcagct tttctgccag ctttattttt ttccgctttt gaaattggag catcacatcg 2918881 aagaaatata catttccctg aaagcaagag atggagaaga aattcccgtc cttatcaatg 2918941 ctattgcgag acacgatagc ggggcttctg tctttgattg tgttctgatt ccaatgcgaa 2919001 agcgaaatga atatgaaaat gagctgctga tagccagaaa tgaggctcag gaagctttgc 2919061 ttgccaaaca gaaagccaat gcggagttag aaattgcctt ggaaacgctg aaagcaaaac 2919121 aagaagaact tcttgagatc aataaacaaa atcaacaatt taaattaaac accaaaagag 2919181 agcttgaact cgccagaaag atccagaaaa actcgttgac tgaaccgatt gtaaacgatc 2919241 aggttcagat tgactcttat tacaacgcat cgagtgaatt gtcaggtgat ctttacggat 2919301 attatcaaat cgatgaacac cgttacggca ttattatcct tgatgtgatg gggcacggaa 2919361 tttcatctgc attgattacg atgtctcttc atcctttgtt ccagcgccag atcacgcaag 2919421 gtctcagccc cgttaaagtt atgaaggaat tggaccggca ccttcacagc ttgtttcaaa 2919481 atgatgagga agcaagacat tattgcactg ctatttatct cgagattgat atagcacggc 2919541 aaagaattga ttatgtcaac gcagggcatc cgccggcact ttggcaggac gatagcggaa 2919601 ctcaacatct gcttcacgcg acctcgcctc cgatcgggat gtttgaagac ttagagtttc 2919661 agtcaagcag cctttcatac acggaggacg gaagattgct tctgtatacg gatggcgtga 2919721 tggatcctac ggcttcatgt tatttatttg atttactaaa ggatcatcct gattcgccaa 2919781 tcgctgacct gaaggagaaa atccttacat cactgcagca tcaaaaggaa gctcatcata 2919841 agagtgatga cgaatgtttt atattagttg atgtaaaata aaatgatcca tgagacataa 2919901 caatgatttg ttacatctca tggatttttt tgtttcagcg tttctttgga atatgtcctg 2919961 actccgcata ttgaaacacc tgcaaggaag gcagcgggtg tccattaaaa tcaaataaag 2920021 cttgattatc tacagcactt cccccatacc acttcccggc gtcttcaggg tcgtattcag 2920081 cagcatagct ggacgcccac cctgacccgt atgtttccca taacactttg tttttctcta 2920141 tctgtgtctt cggcccgact ggaatccacg ccggctccca gtagaaaaca ccaagtcctg 2920201 ctttgcccgt attcgccact gcctccatta catctcttac tgcagttgcc tggccttgaa 2920261 cagaaattgg atatggcaac gtctgcccgc tttttggtgc tgtatttcca tgcccatcgc 2920321 catcctcagc ggtataggtg tacgatgtct ccgccaccat gacttttttg ccgtacgtat 2920381 tggcaacagc cttcagcacg gaggtcaaat tttgtaatgt gccatgccag aaaggataat 2920441 aggagctagc aaacacatca taatccactt tgtttttgct gagtgtttct gcaataaatg 2920501 aataccttcc agccgtttca ggattggtaa aatgcagggc gaccaaaata tttgaatttg 2920561 tctccctgac cgctcggctt ccttcattaa ataattggca catcttcgtc caatcagtct 2920621 caccggcaaa tcctcctgtt gtttcatttc cgacctgaac catgccgatg tcaacgcctt 2920681 ccttgatcat cttttgcagg ctttgtttcg tatactcata gagctttgct ttttttgctt 2920741 caaagctgag attcgcccag gctttgggca ccttttgttt cgctggatcg gcccagaaat 2920801 cagagtagtg aaagtcggcc agcaccttca ttccgttcgc tgtcgctctt tttccgattt 2920861 cgatggcttt ttgaacatca ttgtttcccc cgccataccc gttgccattt gaatcatacg 2920921 ggtgattcca gatgcggacg cgaacatagt tgaccccagc ctgttttaaa gttgtaaaga 2920981 tatcctggcg ttttccgttt gtattgtaaa aggtgacacc gctgttttcc aaagcaataa 2921041 cgctggatac atctgcccct ttgataaaat ccttgttcat cccctctact tttttaacaa 2921101 aaagatcctc tgcccgaagc tctgacacgt gcttctcctt ctcaatggca gcggcatatc 2921161 ctgttgaact acatgcactc cacacgatgg cagccgcaaa gaacattttc actttgcttt 2921221 tcatgatttc atccccccaa gacttagcaa gcgttttcat tctatagaaa aaagaatccg 2921281 cccatatcga gcggagcatc agcctaatgt gtgtttacga caattctcac ttcatacttt 2921341 tccatcgtca ggtcgcctga caatatgtct cctgtcatta tgtccttcac actctgatca 2921401 aacgtgacca gctgtttttc ttccgtgaaa ttcatgacaa aaatataatc attgtcctga 2921461 tcctgcctcg cttgtacgga gacgcctttt ccgtgccgaa ccggaaaaac tggagagaga 2921521 gacaggtctg tgatcagacc ctcatagaaa tcacgctgaa attgatcctc caaacgcgcg 2921581 ccgataaaat acgccttgcc ctgctgatac tcatggcttg tgaccgctgg cgtgcgcgca 2921641 taaaaatctt cttgatacac cgcttccact gaagctgtct ttacatcaat cacggttgca 2921701 taatccttca tttcatatat ttggctgcgg tagctgacag cgtttcgatc cttcggatac 2921761 agggtgtccg tttcaagagg ctcaactcca aatatagctt gaagatccgg atgccatccg 2921821 cctgtgtatg ttaagtcatg ctcattcaca accccgctga tatacgtcat gactaaggtg 2921881 ccgccgtcag ccgtaaacgc ttttaaacgg gaaacggtgt cctcgctgat taaatacagc 2921941 atcgggacga tcagcagttt atatggtgaa aagtcttgtt ctttcgtgat gacgtcgaca 2922001 gggatatcgt gttcccagaa tgtgcggtaa tgctgctgaa gcgtttgcgg ataacgtttt 2922061 gtcgccttcg caaacccctg agcatcctcg agcgcccaat gattttccca gtcatataaa 2922121 atcgcggttt gagccggcct cttcgttccg acaacttcgg acagccgttc caatgtctcg 2922181 cctaccttgg ccacttcttg aaagacgcgg ttcttcgggc tattgtcatg atccacaacc 2922241 gctccgtgta atttttctga tgacccccgt gatttgcggt attggaaata gagaacgctg 2922301 tccgagccgt gggcaatcat ttgcatggat gacagcagat tcatgcccgg gcgctttgcc 2922361 ttgttgacgt tatgccaatt gaccgcgctt ggcgtacact ccattaataa gaagggctgc 2922421 tgcttcaagc ttcggtacag atcattgata aagccgacct tcatcgccaa atcagctgtg 2922481 ctttcccagt cattgtgcca gacaggataa gcgtcccagc tgatggcatc gacatgcttt 2922541 gcaaatttgc tgtagtcgag gccctgatac gggatcaaat ccggtgtgtc agccataaaa 2922601 ttcgttgtga tagggatatc aggcgtcaat tctttcagcg gaatgatttc attttcataa 2922661 aacgaaatcg tttgatcggt gacgaaccgg cgccaatcta aattcaggcc atgcaagcca 2922721 ttttcaccga tcggcgaagg gctttcaatt tgtgaccagt cattgaacgt atggctccaa 2922781 aaaggggtcc accacgcatg gttcaatgtc ttgaggctgt tgtcatattt cgatttcagc 2922841 cactcccgga aagcatgctg gcataaatca cagtggcaat ctcccccgta ttcgtttgaa 2922901 atgtgccaca ttaacagcgc cgggtgatgt ccgtatcgtt ctgctaataa gcggttgatg 2922961 tgccgtgttt tttctcggta gactttagat gtgaggcagt ggttgtgcct tccgccgtgc 2923021 agctgtttga cgcgggaggc attgacgcgc aaaacttccg gataggtttg cgacagccag 2923081 gccggacggg ctccgctcgg cgttgctaat atgacccggc cgcctatact gtgaatccgc 2923141 tcaaaaatat catccagcca ttcaaattga tatacgccct cctccggctc aagtgcgctc 2923201 catgcaaaaa tgccgacaga aaacgtattc gtatgagaaa gcttcatcag tttgatatcg 2923261 tcagctaaaa tatcgggccg atccagccac tgatcggggt tgtagtctcc cccatggagc 2923321 ataaattttg cttttgttac gtgcgttttt tcaagctttg acatcacatt ctcctccttg 2923381 ttctcttagc ccttcgttcc gcctgcggtt aatccggaca caaaattctt ttgcagcata 2923441 ataaagatga cggcaaccgg tatgctgata agcagggctc cggccgcaaa tgtcgtatag 2923501 ctggccccca tgacatcatt cactaaattg aatagaccga cgggcaatgt atatgattca 2923561 ggcgttctca atatggttga ggacagcaca aaatctccga gcggaccggt aaagccgttc 2923621 atggccacga ctgccgccat cggttttgat aatggcagaa tgatctggaa gaagattctg 2923681 gtgctgctgg ctccgtcaat cttggcgctt tcgtctaaat ccatcggaat ggaatccatg 2923741 taccctttca tcaaatacgt attcatcggg atcaggccgc cgatataaag caagattagc 2923801 agccagtggc tattgatcat tcccaagatt tgcgccagca caaacaaggc aattaaagct 2923861 gaaaactgag gaatcatctg cagcaataaa aagagcgtta aagcgtattt cctcccttta 2923921 aaccgaaagc gcgaaaacgc ataggccgta aacgtcacac agagcaaaga ccctgccatt 2923981 gtaaacaggc tgatcttcat agagttgaca taccactgca catattgaag gctttccttg 2924041 cccgcaaata attccttgta atgatcgaat gtcggatgct tcggaatgat ggatgtactg 2924101 attaagctgt tgccgggatt aaagcttgcg cctgccgtcc aaaggagagg ataaacaatg 2924161 atgaccgcca taaaggctag caacaagtaa gagaaaagga gacggatata tcttctgact 2924221 ttcatatctg ccagcatacc ttatgcctcc tctttaaaag actttgtctg tctgaactgc 2924281 cacaatgcga tggagataac aaatacagat aataaaatgg ttaaagccgc agcaagtgaa 2924341 tattggctgg actgcattgt caatttataa atccatgaaa cgaggatatc tgtcccgccg 2924401 gctgttgatc cggttacagc cggacctccg ccattgaata gatagataat attaaagtta 2924461 ttaaagttaa acgtaaactg agtaatgata atcggagcca ttgcaatgaa caccatcgga 2924521 agcgtgatgt atctcagctt tgaaaagaca gaagcgccat caatcgtagc tgcttcatac 2924581 agatcgtccg ggatggattg caatacgcct gttgagacga gaaagatgta cggaaatccg 2924641 agccagccct gcatgagaat caatgcaagc ctcgaccaat tggcatctgt catccacgga 2924701 agcggatcta tcccgaagaa agccaagatg tcgtgattca tcgcaccgaa gctatcatta 2924761 aacagtcccg caaaaattaa aatcgtcaca aaaccgggaa cggcccatgg caaaatcaga 2924821 atcgtccgaa aaaaacgttt aaaccgaagg tctttctggt taacaatgat cgcgagaaaa 2924881 atccccaagg tgacttgcag tgtggatgca gcaagtgtcc aaaccaccgt ccaagccagt 2924941 acatcaaaaa aagtcgacct ccaaatatca actgtgaaaa tatttgcgaa cgtttgaaaa 2925001 ccgacccaat caattaattt tgcaggagga gaatgataca aatcatagtt tgtaaacgct 2925061 aatgcaaagc tgaataagat aggaaagatc acggcgaaaa ttaaaataaa caaagatggg 2925121 ccgctgacga cataaggata gccctcagaa atgatatgct ggtattgttc ctttaaggaa 2925181 cttaatggct tattttcatc acgctgtttt ccgctttgga acgcatcgcg aagatttaca 2925241 taatacaccg caaggccaaa gcaggtcacg atgacagcaa taatcccttc cgccagcaga 2925301 aaaacggaat tatcccgcgg cacttctgtt cccagtgtaa agattcccca aaaccccata 2925361 ttgagcagat ctccaaagac cgcaaaaaac gatgcgccta agaaaagaaa gacaatacct 2925421 tttatccatt gcttgttata aaattgcccg agtcccggaa tgatagaaag caacaaagcg 2925481 acttgacgat gctgcaccgt tttcacctct cttacaatac aaatctagct ttctctttat 2925541 tttccgctgt gctttgcctt aatttgtcct ttggccgttt cagctgcttg atccaatgct 2925601 tgtttcggat ctgccttccc tgttgcaacc gtctgtaatg ctgaatcagc cggcgtccat 2925661 atttcattca tttccggaat atttggtgtt ggctctgaga aacgggattg ttcagtaaca 2925721 gcccgtgccg cctcgctttt cataatagcc gggtcattgg ctagggattt cacagcagga 2925781 acttctttcg tttcttcata tcgtgtttta gaattttttt catttgccag gaaaacggct 2925841 aattcttgcg ccagctcttc attctttgaa aatgcactga cgttgtagct tttgacgccg 2925901 ataaaggagc tcatgttttt cccattttcc agcttcggca gtttcgtaat gccataattg 2925961 attcctgcat tcgaaaaggc ttctacattc catggaccag aaataattgc ggcggctttt 2926021 ccttctgtga acagcgattc caacacgtta atcccttgtt ctccaataat gccagccggg 2926081 aacaggccat ctttgtaaaa cttctgaatc agcgccgcac ctttgacagc tccttcatta 2926141 ttgattccaa tgtctgacgg gttatagctc ccatctttgg cctttccaaa aatgtatccg 2926201 ccatatccgc tcatcacact ttctgcataa taaatttgat cgaatagggc taaaaagcca 2926261 aatttgctgc cgtcagcagt ctttttggaa tagtcgtacc actcttccag cgttttgggc 2926321 aattcctttt ctgtgatgag atctttgttg taaaaaagca cagtcgtttc gaccgctttt 2926381 ggcagtccat aaagcttttg atctaccatt tgagactgaa tggaagcgtc agtataaagt 2926441 gattgaacgt cttttttgac atgtaattcc ttgagtaatc cttccgtgac agcggttccg 2926501 atttggtccc ctggcattgt taacacgtca gggcctgtgc cggccggtcc atccattcgc 2926561 aaatcttcaa tctgcttggc atacggtttt tcaacgactt tgaccttcac atcatgctct 2926621 ttttcaaatg cagccacagc gtctttaatg ccgttgctct tttctttatc ctcccataca 2926681 acaagctctg acccttttga actcgatttg gcgctgctgc tttcctttgg gccgcaagcc 2926741 gccaaggata aactgacagc tgcgcagagc atgaatacgg aacacttttt tgccattttc 2926801 attgattgtc accctttcgg taggaatgaa agcgctttaa agataatata gcatgcctga 2926861 gaaaatgtgt aaacaaacta tttacttcat agagtaaatt tttttaccta aataaaaaat 2926921 gacttagtgt cctaagtcat ccttaattca tactcttcct gacgattaat tctgcgccca 2926981 catataatgt ttttaccgtt cttctcttgt cctgcacttg ttcaagcagt aattgaacag 2927041 cgtttttaca taattcatgt atatcaatat gaaacgtcgt cagaggaggc gagacatact 2927101 tcgcgaagct gatgttgttg atactcacaa tgcttaccct gtttggtatg gcaattcctt 2927161 tttcgttcag ggcttgcaga cagcccactg caatcgggtc cgctgcaatc ataaaagcag 2927221 tcggaagctg atcgcctaat gtgtcgatcg ctgctgacat caggcggtag ccgttttcta 2927281 cagagaatcc gcgatgacag aaaatatagc gctcgtccag catggctttt tccctcatat 2927341 aggatctgaa ggtttgttca cggatgtcca tttcatcctg attggtattc ggatttttgt 2927401 atgtgccgcc gataaaaccg atgctcttat gccccttctc agtcaggatg tttaccgtct 2927461 tccttgtcat ttgtgccaaa tcgggcctta ccgagtcaaa atgatcggga tcaggagttg 2927521 aatcgatgaa cacgccgttt tcagtgagat ttctgaggaa agccagctct tcatctgaaa 2927581 atgtgccgac ggcaataaac ccttccgtat gttcaggaat gctctcgatt ccatccgcta 2927641 ttttataagt ggtcatatcg acattgaatg ctttcgccag tttctctact tctaatctca 2927701 tcgttttaaa atagacatct tctaattctt ctttatctgt cagccaatat aaaaacgcaa 2927761 tatgtttcac cagcggcctt actgtttttt tgcggtaatt gagcttttcc gccgcttcat 2927821 agattttctc ccgtgtctca tcaggaacag aaaggctttc atcgttattt aaaacgcggg 2927881 aaacggttga gattgaaaat cccgcttcct gcgcgatatc tttaattgtc gccattgtat 2927941 ctgcctccat tattcagctc gcattgtttt agtaaaatat tttactttct ttttcacaaa 2928001 tgtcaagtgc acaaagccct ctggctgcca tgtaaaaaga ctgaaccatt tgcggctcag 2928061 tctcagttgt tcgtatcatt cggaaccggc ggaattgccc gggaaatgag ttggttattg 2928121 cacattttcc tcgaaatatc ccgaaagcac atcttccaca ttcgtcaaat gcgccagcat 2928181 ggcggcttcc gcctgtgcac cgttcccggc agccacagca ttgtaaatcc gttcgtgctc 2928241 ctcatacagc cgctgaacgg aggtcttctt ggaaaacagc cagattttcc tcgtttccct 2928301 cattgtttcc agcagcaatg atgacacgtg attcatcaag tgtttaagaa gttcattttg 2928361 agaagcgtcc gcaagcgcaa gatgaaatgc aaagtctgct ttctctccca gctccccgtc 2928421 cgcttcaatg ctgcccattt cctttagtgc atcctgaatt ctttcgagat ctgcttctgt 2928481 ccttttttca gccgctagtg aagccacgcc gatttcaagc agttttctga cctcgagcag 2928541 ctgcttgacg tcctcttttt tcatcagaag ggcggctgag agcggctgag aaatttgatt 2928601 gagctcaaat tccttcagat acgtgccttc tccctgtttc atttcgacaa gccccatcgc 2928661 ttttagcgca gaaagtgctt cgcgaaccgc tgaacggctg acttgaaagc tctcagcaag 2928721 cgcctgaaca gagtccagtt tatcccccgg cttcaattcg ccatttttga tcatatctaa 2928781 tagggcatcc gctacttctt catatatttt tttgttttaa tctgtttata tttcaatgca 2928841 attcaccccg taacttgtag gtctggctgt ttacgatcta ttatactctg ttttgtgggc 2928901 cgccaaaaga ttttgactat tttgtcaaaa agtcttgtac tttgattttt ttcaaaatat 2928961 aatgctaggt aactggtctt attacccagt catcagatga tcatatcatc tatagaaacc 2929021 gcttacatat ggcgccagtt tatgtttcaa ggaggggttt gggatgcaat ggacacaggc 2929081 atatacgcct atagggggaa atttgctatt atcagcgctt gccgcacttg taccgattat 2929141 tttctttttt tgggcactcg cgattaaacg gatgaagggg tatacagcag gcttggccac 2929201 attggggatc gcccttatca ttgctgtatt ggtttatcgt atgccggcgg aaaaagcgct 2929261 gatgtccgcg acacaaggag ccgtatacgg attgttgccg atcggctgga tcattgtgac 2929321 gtctgttttt ttgtataaaa tcactgtgaa aacgggacag tttgatatca ttcgcagctc 2929381 tgttctctcg attactgatg accgacggct tcaagctctc ttgatcgctt tttcattcgg 2929441 ggctttttta gaaggggcag caggcttcgg agcgccggtc gccatttctg ccgcgctgct 2929501 ggtcggtctc ggctttaatc ctctttatgc tgcggggatc tgtttgatcg ccaatacggc 2929561 gccggttgcc tttggggcaa ttgggattcc aattacagcc gtagaagggc cgacagggat 2929621 tccggcgatg gagatttcgc aaatggttgg gcggcagctg ccgtttttat ccgtatttat 2929681 tcctctttat ttaatcatca tcatgagcgg gttcaggaaa gccttggaga tctggccggc 2929741 gattctcgta tccggtgttt cctttgctgt tgttcaatat ctcagttcca attttttagg 2929801 gcctgagctg cccgatgttt tgtcagctct tgtttcaatg gctgcgcttg ctgtgttttt 2929861 gaaatggtgg aagccgaaaa caacattccg gtttgccggt gaacaagagt cggccgcctc 2929921 aattgaaacg gcgcgcacaa atccggcggc gcctgcatac agaggcggac agatttttaa 2929981 ggcttggtcg ccatttctgc tgctgacggc gatgatttcc gtatggggca ttccatctgt 2930041 caaatccgcg ctgaccgggc attatgaagg ctctgcggtg ttcttgaagt ggctgaatgc 2930101 tgttggagaa aaactgactt tttcccccgg tgtgcctttt ttgaacaatc agattgtcaa 2930161 tgctgacggt acgccgattg aagcggttta caagttggag gtgcttggtt cggccggcac 2930221 cgcgatattg attgccgcag tgctgtcaaa attcatcacg gcgatttcgt ggaaagactg 2930281 gggaaccgtt tttaaagaaa cagtccagga attgaagctt ccgattttga ccattgcttc 2930341 tgtcgttggt tttgcctatg tcaccaactc ctcgggaatg agcacgacac tcgggatgac 2930401 actcgcgctg acaggttcga tgtttacctt cttttcgccc gttctcggct ggctcggcgt 2930461 cttcattacc ggctcggata cttctgccaa cctgctgttc ggcaacctgc agaaagtcac 2930521 cgcattatca gtcggcatgg accccgttct gtctgtggcc gccaactctt caggcggtgt 2930581 cacaggaaaa atgatttcac cgcagtcgat agcggtggcg tgcgccgcgg taggactcgc 2930641 cggaaaggag tcagatcttt tccgctttac cattaaacac agtctgtttt tgctgctgct 2930701 cgtctgtatc atcacctttt tgcagcatca cgtattcagc tggatgattc cttaaaaaaa 2930761 tcctcccgtc tagggaggat tttatttata tcgctttctc gctgccgatg acggaatatt 2930821 catttgatcg cgatattttg ccacggtgcg tctcgagatt tggatgccgt gttgttcata 2930881 cagcaaatcg acaagctttt ggtctgaaag cggttttgtt ttgtcctctt gattgatcag 2930941 gttttccaga tgcgttttga ctgcataatt cgacgcatct ccatcacctg aagcctcggc 2931001 ttttgctgag aaaaagagtt tcatctcaaa cagcccgtaa ggcgtttgta ttgttttccc 2931061 tttaatggcc cggctcacag ttgattcatg aaggcttaga cagtctgcca cctctctgag 2931121 agtcagcggc ttcattgcgc ttcgcccttt cagaaagaaa tccttttggc gtgtgatcag 2931181 ttcattgata attctcgtga ttgtctgttt tcgctgccgc agcgcgcggc tcagccagcg 2931241 ccactcctga tatttcgcag ataaatagga gacagtatcc tgacaggagc cggatgataa 2931301 aagcgttctg tactgcggat gcagatcgat ctcgggaaac gagcgggtat tcagttccgc 2931361 tgcgatgtgc ccatttttta cggtgataaa aatgtcaggc tcaatataca catcttgctc 2931421 tggccgggca aacagaaggc caggtctagg atgaagagcc gcgatatcat ctgagatatc 2931481 ttgaatggta tgaagcggaa ttcccgtctc tactgaaagc gttttccatt ttttttgcgc 2931541 aaaagcatca aaatgagctg aaaccagcat ttccgcttgt tcatttctgt tcggcagccg 2931601 ctgtaattga agaaggatgc attcctgcaa agatctcgcg ccgattccag ccggttctaa 2931661 cgactggagt tttgccaaaa cagcctccgc ttccttggcc gatacagata atcgccgtgc 2931721 tgcctcctct atatcttctt ccaagtaccc gtttgaatca agcgaatgaa tcagataatt 2931781 aaaaatcttt ttttcagtgt ttgtcagatt catatcgagt gactgctgtt ttaacgcatc 2931841 ctgcaatgtt ttttgcggat tacttaattg aaggcccgct tcctgtgcat tcatcctgtt 2931901 tttgtttgtt ttatggtaag atagtggcgg tgtgtctgtt tcctttcgtt caataagagg 2931961 gttttccagt gagagctcat caatgtactc ggcgagttct gccgaatgat agccaagcag 2932021 cgtgatggcc tgcctgagct cctgtgtcag ttgaggcttt aatacttgta cttgctgaag 2932081 tttcatatcc atcttgctca ctcccctttc ttcattgtac atgattgaga tcacaccgta 2932141 tacatttatg aaaaaggagc tgccaaagaa atgtctgaac ttttttccgt cccttatttt 2932201 attgagaatt taaaacagca tattgaaatg aatcagtctg aggataaaat ccacgcgatg 2932261 aacagctact accgttccgt cgtctcaaca ctagtgcagg accagctgac gaaaaacgca 2932321 gttgtcctga aacggattca gcatttagat gaagcataca acaaagtcaa acgtggagaa 2932381 tcaaaataaa ccttccgaat tcgggaagat gatgatcggt taaagggcta acgttcgcat 2932441 ctatagggga aatctgttta taatggggga aaaagggaga gaacacaatg actcatcaaa 2932501 tagtaacgac tcaatacggc aaagtaaaag gcacaacgga aaacggcgta cataagtgga 2932561 aaggcatccc ctatgccaag ccgcctgtcg gacaatggcg ttttaaagca cctgagccgc 2932621 ctgaagtgtg ggaagatgtg cttgatgcca cagcgtacgg ctctatttgc ccgcagccgt 2932681 ctgatttgct gtcactttcg tatactgagc tgccccgcca gtccgaggat tgcttgtatg 2932741 tcaatgtatt tgcgcctgac accccaagta aaaatcttcc tgtcatggtg tggattcacg 2932801 gaggcgcttt ttatctagga gcgggcagtg agccattgta tgacggatca aaacttgcgg 2932861 cacagggaga agtcattgtc gttacattga actatcggct ggggccgttt ggctttttgc 2932921 acttgtcttc atttaatgag gcgtattctg ataaccttgg gcttttagac caagccgccg 2932981 cgctgaaatg ggtgcgagag aatatttcag cgtttggcgg tgatcccgat aacgtaacag 2933041 tatttggaga atccgccggc gggatgagca ttgccgcgct gcttgctatg cctgcggcaa 2933101 aaggcctgtt ccagaaagca atcatggaaa gcggcgcttc tcgaacgatg acgaaagaac 2933161 aagcggcgag cacctcggca gcctttttac aggtccttgg gattaacgag ggccaactgg 2933221 ataaattgca tacggtttct gcggaagatt tgctaaaagc ggctgatcag cttcggattg 2933281 cagaaaaaga aaatatcttt cagctgttct tccagcccgc ccttgatccg aaaacgctgc 2933341 ctgaagaacc agaaaaagcg atcgcagaag gggctgcttc cggtattccg ctattaattg 2933401 gaacaacccg tgatgaagga tatttatttt tcaccccgga ttcagacgtt cattctcagg 2933461 aaacgcttga tgcagcgctc gagtatttac tagggaagcc gctggcagag aaagttgccg 2933521 atttgtatcc gcgttctctg gaaagccaaa ttcatatgat gactgattta ttattttggc 2933581 gccctgccgt cgcctatgca tccgcacagt ctcattacgc ccctgtctgg atgtacaggt 2933641 tcgattggca cccgaagaag ccgccgtaca ataaagcgtt tcacgcatta gagcttcctt 2933701 ttgtctttgg aaatctggac ggattggaac gaatggcaaa agcggagatt acggatgagg 2933761 tgaaacagct ttctcacacg atacaatcag cgtggatcac gttcgccaaa acaggaaacc 2933821 caagcaccga agctgtgaat tggcctgcgt atcatgaaga aacgagagag acgctgattt 2933881 tagactcaga gattacgatc gaaaacgatc ccgaatctga aaaaaggcag aagctattcc 2933941 cttcaaaagg agaataaata tggggaaaac aggatacatt ggtgctgcca ttgttgtggc 2934001 agcttgtatc attattttgt cggccgtggt atgtttacgg gacacagtct attaccagcc 2934061 tatgcgctgg actggcatca tactgttttt cgcgggaatt gtgatggttc ccgcatactc 2934121 agcaaaaaga aaacccggaa aagagaagta attctctttt ccgggttttt atgtttatta 2934181 taatcttccc gcgcgaatat cgtctgtcat tccctcataa ggagccttcg aaatcacttc 2934241 ttcgttgtcg actccttcat ttttcagaaa tgtaatttcc gcaaattcag gtacaacgta 2934301 ttttggatac gtttcatatt tttcgcggga ttctttcatc aaatcaatgt ggtcattttg 2934361 gtagcaaacc gtaatttcag gatgttcatg cacccatttc gggaagaaaa taatgccatg 2934421 catgcgtttt tcatttggca taaagtttaa tgaaacatcc gtgccagtcg gctctgtcca 2934481 agacacttta tatacgcctt ctgtcagttt gacaatattc acttcctgat ctcgaaccca 2934541 gcgtccggca accattccgc tatgaattct ataatcaatt gtatggtcgt ttttaatata 2934601 aatctcgtat tcccatccgt tttcatacgt ataaatcatg tggcttccga taaagttttc 2934661 catcttacac actctcctta gtcttttact gtacttcata aatgtctagt agaacgtaat 2934721 caggggttct ttctgcggaa ccgataaaca agcggtcatg gagccattga tagacttcac 2934781 tgcctgtttc aaacgtcggt accgtacgaa aataaacatg ctccggttca ataatttccc 2934841 cggctgccgc ttgttttcga aacggcttgc tgacttgccg tattccattg ttttcaatgt 2934901 aaatcagttc atgatctgct gtttcaatca catacctggc agataaatct gttctgccgt 2934961 tagcgcgaat catttgtgaa tcggcaccgc ccggcaaaat acgtcccttt acttccccgg 2935021 ttattgttcc cgaacgaatc ggaatgaatc atctcagtcc caggcttgtc tcaccaatcg 2935081 tgataggcgg atcaaccttg atttctaaag aggcgaatgg ttttaaaacc ggcttcttca 2935141 cgagaaccac ctcaccttca gaaaaaatca tgtaactatt tacatgttca ctttaacacc 2935201 attgcagtta actgtcaaac aataggaaca taaaaaaaca aggactgttt gaagacagtc 2935261 cttgtctgaa gctagctttg ataagcaaga tatgtgctga cagtgctttt ggcaagacag 2935321 gcagaggaat ctataatcgg aatctcactt tgaatatgat ctaacaccgc atttaaatcc 2935381 gtgcaggctg aaatgatgat gtctgcatgc tgactgattt cttcatatag cgtctgccac 2935441 aatgcttgtg tatgctgcat atgatttggc tgtttgattg cggcgataag ctggttcaca 2935501 gcctgctgcc aatggtcctt gtgaataact tcttgtccat ttcccttcag aactttttgg 2935561 tagatggcgg attggatggt tggctctgtt cctaaaacca ccgctttttt tgcgggatgc 2935621 ggaatctctt ttatcgtttc ctcaacaata tgcaacatag gaactgacaa tgcctgctga 2935681 atctcttcat agtagacatg cgccgtatta caaggcagcg caatgaaatc cacgcctgtt 2935741 ttctcgagct ttaccgctcc gtcgataatc gcttttttca tctcgtcatg gtcaattgga 2935801 cgatctgcat agaagggcgt cgggcatgaa tagatcatca tgtgcggata gtcaatatcg 2935861 tttgaagccc catacagctt ctgacagtaa tcaatcacct tatcaataaa cggcgaggtc 2935921 gatttcggcc ccattccggc taatattccg atcatcaaat tcattccttt ctacttcgta 2935981 cggaccgctt cttcctctga gccatcctca tagaggataa agcttttcgc agcatcctca 2936041 cctaatgtaa actcgacttc aacagacaat gctcgcagaa agaaacgggt ttccgaggaa 2936101 ggaaataact ccagtctcag ctgtccggcg atctccaaat aaagccgttc attctcggtt 2936161 gtcacctgtg cagccgtccc atcctgcaac aggtagctgc caacatagcg gctgtatatc 2936221 gccgtatcaa ttgctttttt ctttttatca gcaggacgtt ccgggacatc atatggctgg 2936281 ccaaatagaa tatgttccgc cgccttcaga atcgcttgtt catattcagt atcctcttcc 2936341 ttattactca aatagatcag cgttttacga tgatcgatat atcggatcat catcgtcgaa 2936401 tagccgggcc atcctccgct gtggctgaca atccgccctt tttcaggact gttttgcagc 2936461 acccagccaa agccataatc aattgtttct ccattgttga ggcgcactgg agaaaacgca 2936521 gattccttag aagccttgct gatgaaatcg tcctgatata aagcctgatc aaatcgaaac 2936581 aaatcgcttg tgacagagtt aaccgtccca tctccctgta tgccatcgag atacacaaca 2936641 tagttcgttt cctccagctc atcagggagg acgtatgttt cggaatgtac atcatacaca 2936701 tatccatatg cataatgatc aattcgctca ggcgaaagcc tcctgttata cactcttgtt 2936761 tcattcatgc ctgccggtaa aaaaatactt gtttttataa aatccgcata gctcatgcca 2936821 gatgcttttt caatgataac cgccagcagc acataccccg tattgctgta catccagcct 2936881 tcattcggtt caaaataacc agatagcccc tcattcatca gcatatcgac aatatcctga 2936941 ttcaccgcaa tcttgtgtga atcccaattg gcaaaaaacc atcccatata atcaggaagc 2937001 cctgacgtat ggttcaataa atgccgaatc gttacgccct gatacggaaa accgggcagc 2937061 cagcgatcca ctttatcctc atagccaaga atccccttct cctccagcaa gatgattccc 2937121 aatgctgtaa aaggctttga caaagacgct aactcaaaca aagagttggt tttcaacggg 2937181 cgtttttccg tcatttccgc atagccaaaa gagtggtgat ataaaatatc gccaccctcc 2937241 gcagccagaa ccgtcccgtt aaactgatgt ttttcgccta atgtctcaaa taacgtctga 2937301 agatgctttc ttttattctg cttcattcct ccacctccca tatctctgta cgttactaac 2937361 ctactaacgt ttcaaatatt ttgaaaaatc cttcagttag agatcctttt taacccatca 2937421 catatacctg ccgttcacta ttatttagtg aaatgagata ttatgatatt ttctgaattg 2937481 tgattaaaaa ggcaacttta tgcccatgca acagaaacta taaaaaatac agagaatgaa 2937541 aagaaacaga tagatttttt agttctttag gcccgtagtc tgcaaatcct tttatgattt 2937601 tctatcaaac aaaagaggaa aatagaccag ttgcaatcca aacgagagtc taatagaatg 2937661 aggtcgaaaa gtaaatcgcg cgggtttgtt actgataaag caggcaagac ctaaaatgtg 2937721 taaagggcaa agtgtatact ttggcgtcac cccttacata ttttaggtct ttttttattg 2937781 tgcgtaacta acttgccatc ttcaaacagg agggctggaa gaagcagacc gctaacacag 2937841 tacataaaaa aggagacatg aacgatgaac atcaaaaagt ttgcaaaaca agcaacagta 2937901 ttaaccttta ctaccgcact gctggcagga ggcgcaactc aagcgtttgc gaaagaaacg 2937961 aaccaaaagc catataagga aacatacggc atttcccata ttacacgcca tgatatgctg 2938021 caaatccctg aacagcaaaa aaatgaaaaa tatcaagttc ctgaattcga ttcgtccaca 2938081 attaaaaata tctcttctgc aaaaggcctg gacgtttggg acagctggcc attacaaaac 2938141 gctgacggca ctgtcgcaaa ctatcacggc taccacatcg tctttgcatt agccggagat 2938201 cctaaaaatg cggatgacac atcgatttac atgttctatc aaaaagtcgg cgaaacttct 2938261 attgacagct ggaaaaacgc tggccgcgtc tttaaagaca gcgacaaatt cgatgcaaat 2938321 gattctatcc taaaagacca aacacaagaa tggtcaggtt cagccacatt tacatctgac 2938381 ggaaaaatcc gtttattcta cactgatttc tccggtaaac attacggcaa acaaacactg 2938441 acaactgcac aagttaacgt atcagcatca gacagctctt tgaacatcaa cggtgtagag 2938501 gattataaat caatctttga cggtgacgga aaaacgtatc aaaatgtaca gcagttcatc 2938561 gatgaaggca actacagctc aggcgacaac catacgctga gagatcctca ctacgtagaa 2938621 gataaaggcc acaaatactt agtatttgaa gcaaacactg gaactgaaga tggctaccaa 2938681 ggcgaagaat ctttatttaa caaagcatac tatggcaaaa gcacatcatt cttccgtcaa 2938741 gaaagtcaaa aacttctgca aagcgataaa aaacgcacgg ctgagttagc aaacggcgct 2938801 ctcggtatga ttgagctaaa cgatgattac acactgaaaa aagtgatgaa accgctgatt 2938861 gcatctaaca cagtaacaga tgaaattgaa cgcgcgaacg tctttaaaat gaacggcaaa 2938921 tggtacctgt tcactgactc ccgcggatca aaaatgacga ttgacggcat tacgtctaac 2938981 gatatttaca tgcttggtta tgtttctaat tctttaactg gcccatacaa gccgctgaac 2939041 aaaactggcc ttgtgttaaa aatggatctt gatcctaacg atgtaacctt tacttactca 2939101 cacttcgctg tacctcaagc gaaaggaaac aatgtcgtga ttacaagcta tatgacaaac 2939161 agaggattct acgcagacaa acaatcaacg tttgcgccaa gcttcctgct gaacatcaaa 2939221 ggcaagaaaa catctgttgt caaagacagc atccttgaac aaggacaatt aacagttaac 2939281 aaataaaaac gcaaaagaaa atgccgatat cctattggca ttttctttta tttcttatca 2939341 acataaaggt gaatcccata tgaactatat aaaagcaggc aaatggctaa ccgtattcct 2939401 aaccttttta ggaatattgc tgtttatcga cttatttcca aaagaagaac atgaccaaaa 2939461 aacaaaatca aaacagaagc cggactaccg ggcggcatat cattttacga cgccggataa 2939521 atggaaaaat gaccctcaaa aaccgatcta ttttgatggc aagtatcatt atttctatct 2939581 atataaccgg gattacccaa aaggcaacgg cacagaatgg cgccatgccg tctcagagga 2939641 tttggtgcac tggaccgatg aaggcgtggc gattccgaaa tatacaaacc cggacggtga 2939701 tatttggacc ggttccgtcg tggtggataa agagaacaca gccggcttcg ggaaaaatgc 2939761 gcttgtcgcg attgtgacac agccctcagc caaagacaaa aaacaggaac aatatttgtg 2939821 gtacagcaca gataagggaa aatcattcaa attctacagt ggcaaccccg ttatgcctaa 2939881 tccgggcaca gacgatttca gagatccgaa agtcatatgg gatgaccaag ataacaaatg 2939941 ggtcatggtc atggctgaag gatcaaaaat cggcttttat gaatccgata atcttaagga 2940001 ctggcattac acaagcggat tcttcccaga acaggcggga atggtggaat gtcccgacct 2940061 ctacatgatg cgggcaagcg acggaacgaa taagtgggtt ctcggtgcca gcgcgaatgg 2940121 caaaccgtgg ggcaaaccaa atacgtacgc ctactggacc ggaagcttcg acggaaaaga 2940181 attcaaagcg gatcagactg aagcccaatg gcttgactat ggcttcgact ggtatggcgg 2940241 tgtgacgttc gaagacagca aaagcacaga tccattagaa aagcggtatg cgcttgcctg 2940301 gatgaacaat tgggattatg ccaacaacac cccgacaatg aagaacggct ttaacggcac 2940361 agattctgtc atacgcgaac tccggctgaa ggagcaggat ggaacataca gcctcgtctc 2940421 acagccgatt gaagctttgg agcagctgac tgtttcaact gacgaaatag aggatcagga 2940481 tgtgaacgga tcaaaaacat tgtcgataac aggtgatacg taccagcttg atacggatct 2940541 ttcttggtca gagctaaaga atgcaggcgt caggctcaga gaatcagaag accaaaaacg 2940601 ccatattgat gtcggcattt tcgctgaagg cggctatgct tatgtcaata gagcagccac 2940661 aaatcagcct gacaaaagca atacctatgt cgaaagcaaa gctccttatg atgtaaacaa 2940721 acgtaaggtg catttgaaaa tacttgtcga taaaacaacg atagaagtat ttgttggcga 2940781 cgggaaaacc gttttttcaa atgaagtctt cccaaagcct gaagataaag gaattaccct 2940841 ttattctgac ggcggcacag cctccttcaa aaatataaca gtgaaacact ttgattcgat 2940901 tcatgaataa aaacaggggc ggcgcaggct gcccctgttt ttttattagg agcggtattc 2940961 tctgttacat attgggcatt gtaaggaata taaggctggt ttcaaaggag gaagcgaatg 2941021 tctaaacaag gaaattttca aaaatcaatg tcgctgtttg atctgatttt gattgggatg 2941081 ggagccatct ttggatcagc gtggctgttc gctgtcagta atgtcgcttc aaaagcaggg 2941141 ccctccggcg ctttttcctg gatcctcgga ggagccatta ttttgttaat cgggcttgta 2941201 tatgcggagc tcggagccgc tctgccccgt accggaggca tcattcgata ccccgtttat 2941261 tcacatggcc accttgtcgg ctacttaatt tcgtttgtca cgattgtcgc ttatacaagc 2941321 ttgatttcaa ttgaagtgac agctgtgcgc cagtatgtgg cctattggtt tcccggcctg 2941381 accattaaag ggtctgattc gcctaccatt tccggctgga tcttgcagtt tgccctatta 2941441 tgcttgtttt tcctgctgaa ttattggagc gtcaaaacct tcgctaaggc gaatttcatc 2941501 atatcgattt ttaaatatat tgtgccgatt accatcatta ttgtgctgat ctttcatttt 2941561 cagccggaga atttatccgt tcaaggattt gcaccgtttg gatttacagg tattcaggct 2941621 gccatctcga caggcggcgt catgtttgcg tatctcggcc tgcatccgat tgtatctgta 2941681 gcaggtgaag tccaaaatcc aaaacgcaat atcccgatcg ctttaatcat ttgcatcatc 2941741 gtttcaacca tcatttatac tgttttgcag gtcaccttta ttggtgcaat cccgacagaa 2941801 acactgaaac atggctggcc ggcaattggc cgggagttct cattgccgtt taaggatatt 2941861 gcggtcatgc tcgggttagg ctggcttgca acgcttgtca ttttagacgc cattctgtct 2941921 cccggaggaa acgggaatat ctttatgaat acgacatccc gccttgttta cgcctgggcg 2941981 cgtaacggca cattatttgg catattctca aaggtcaata aagatacggg gacaccccgc 2942041 gcttcgcttt ggctttcgtt tgccctgtcc attttctgga cacttccctt tccttcgtgg 2942101 aacgcgctcg tcaatgtctg ttcagtcgcg ctcattcttt catatgcgat tgcacccatt 2942161 tcttcagctg cgctgagggt caacgcgaag gacttaaaca ggccgtttta tttaaaggga 2942221 atgagcatta tcgggccgct ttcctttata tttacagcgt ttatcgtgta ctggtcagga 2942281 tggaaaacag tctcctggct gctcggttca caactcgtga tgtttttgat ctatctctgt 2942341 ttcagcaaat atacgcctaa agaagatgtc agccttgctc agcagctgaa atcagcctgg 2942401 tggcttatcg ggttttatat tatgatgctg atcttttcct acatcggttc tttcggacat 2942461 ggtttaggga ttatcagcaa tcccgtcgac ctcattttag tcgcgatcgg ctcacttgcg 2942521 atttattact gggcaaagta taccgggctc ccaaaagccg ccattgatta tgataaataa 2942581 agaagcaaga ggttttcttg cttctttatt ctttacaaac aaacatacac gcgataaaat 2942641 gaatgagagt cagtcattac tggaggtgtt cctcatgcca aaacaaacat cgggtaaata 2942701 cgaaaaaata ttgcaggcgg ccatagaagt catttctgaa aaaggcctcg acaaagcttc 2942761 tatttctgat attgtcaaaa aggccggcac tgcccaagga acattctatt tgtatttttc 2942821 atctaaaaat gccctcatac cggccattgc agaaaatctc ctcacccata cacttgatca 2942881 aatcaaaggt aggctccatg gggacgagga tttttggacc gttttagata tattaattga 2942941 tgagacattt ctcattacag aacgccataa ggatattatt gtcctctgtt attccgggct 2943001 tgcgatcgac cactccatgg aaaaatggga gacgatctat cagccttatt attcctggct 2943061 tgaaaaaatc atcaacaagg ccattgcaaa ccatgaggta acggaaggaa tcaattcaaa 2943121 atggacggcc agaacgatta tcaacttggt cgagaatact gcggaacgat tctatatcgg 2943181 atttgaacaa gatgaaaatg ttgaagtgta taaaaaggaa attttcactt tcttaaaacg 2943241 gagcttaggt actgcttaaa aaatgactgg gtaacaccgc tcatttttta atgccctaaa 2943301 aatgactgac gttcattcat aaaatagaga ggtgtttcat ttgaattggg ttcttgtttt 2943361 tattgcaggg cttttagagg ttgtttgggc ctcttccctc aaacatgccg attcgctttt 2943421 ggattggatc atcattttta tcttaatcgc ggtcagcttt atcctgttga tccgctctta 2943481 tcaaaaaatc ccgatggccg cggcgtacac tgtgtttgtg ggaatcggaa ccgtcggaac 2943541 atatctgact ggaattgttc tgggcgaatc cttctcagca gcccaaatgt tctttttagc 2943601 tttattgctg gctggcattt taggaatgaa attatttacg aaagaaagca aatctcagcc 2943661 gggaggtgaa aaataatggc atggttttta ttagtgattg ccggcataga agaaattata 2943721 gctgccattg ccatgaaata tatagacgga acaagaaaaa aatggccgat cattgtgatg 2943781 actgttggat tcggcttatc cttttactgc ctgtcccaag cgatgatcgt cctgcctgcc 2943841 ggagtcgcat atgccgtctg gactggcatt ggaagcattg gtgtttcggc ggtcgggctc 2943901 atctggttta aggagcggtt tcagctttca caggtgattt cactttgcct tatcctagcc 2943961 ggcgtcatcg gcctgcgtct tacgtcatct tcataaaatc aaggcatata cagctgtata 2944021 tgcctttgcc attaagcttc gtgatgtttt tgaagatgaa gcggcggcgg gatgagccag 2944081 cctttgtttt ttagcagcct taagtatttt gcgccggttg ccgctttcga catatgaaat 2944141 tgcccaaaca tcatggcaat atcctcacga atcgattgcc ccatcatttt gctgcatgtc 2944201 acaagacctg cagcattttc tgctgccgcg gaagccgcca catccggatc gagaaaccgt 2944261 gcaccaggcg gaatatcgtt aagatctgct gtcggcggtt caggagaagc cggcggcagc 2944321 gccaccccgt tttctttcag gatcgtgctg acctgtttga tttcatcttg gcatttctca 2944381 atagactcac gaagcagctt cttcaggtcg tcatcaccga catgattcaa tagcatttgg 2944441 taattgccga ccattttatt gcccgccatc acataactcc acaagccgaa tacctcaccg 2944501 taatgcatcg gttcatcctg cggatttccg cttaaaatac ccatgctcat tctcctccca 2944561 tattcaatat tgcacatttc ataacgtgcc caagcggagg aacatttatg tttcagcgga 2944621 aaagatttat gaaatgaaac aaaacaaaaa agacaagagt ggcaagttgc caaaccattg 2944681 tctttcctgt tgtttgattg gacgcactga agggattcgc accccgacag acaagatacc 2944741 ggaaaccatt caagtgcttt ttagtatgag tcattgattc tgtctttaat aaactttaac 2944801 gagatggcgg gatgctttgc ggaaaacgaa atacattttc ggggtcatat ttcgccttta 2944861 tttctcgaag ccgcgcaaag tttgcgccat aatattcttt tccgaagttt tcaatgtttt 2944921 gatctggaac attaacatat gaacctgcta catatggttg catcagctga cgcactcttt 2944981 caactgatgc aagatttgaa tcttcttgtg atttattttt ccaactagcc gtccattccg 2945041 tataaaataa tggatggcgc caaaaaaagg cagtttcgtc tttagggact ctgcttatag 2945101 caccacccca attgataaaa aagaaattgg cttctgttcc agtagcatct tccaaaaatt 2945161 ttctcatgat tgaaatgggt tcgtcagacc aaaaatcatg accccatgcc gaggagaatt 2945221 taacactctg atcatttctg ccagggatgg gttcgtcagg gtctaagaaa tctatagcat 2945281 ctggatagta taatgttttg atatctgctt ctgttggagt tcccgcatgt aataaaggtt 2945341 ttaataatcg aatcaattca gttttcgaac cgaggaaaat tccttctgca tgacacaaac 2945401 catttatttt gctgtaaatt tcaaggtagc atcctaatcg ttcatctaca aacggagccc 2945461 atttctgcca agctttaaat accgtttcta attgttccca cggccagata atattgaaga 2945521 cggttgcagt tttaggggca cgatgaactt tgaatgtata ttgggtatta tatccaaagt 2945581 tacctcctcc tccgcctcta gaagcccata gcaaatcctc attgtgagat tgatctgcgt 2945641 gaataatcct tccttttgca tctaccgttt tcagcgcgag aaggttatca cttataaggc 2945701 caatcgatcg tgagagtaca ccaaatccgc cgcccatcgt aattcccccg attccaactg 2945761 ttgggctatc tccaaacgga gccataaaac cgtctcgagc taatcccttt acaagcgggc 2945821 caacgggaat accagtttga acggttgcaa tagcgttttc ttcatctaag aaaactttat 2945881 tcatgtcact cacatcaata acaattcctc cacttactac tgaaaggttc ttatctaaag 2945941 catggcgacc gcttctgaca cgtaagggca ctttattctc acgagcccat ttaatggcat 2946001 tacttacatc gtatgaattt tgcgcaaaaa caaagacaag aggatagaca tccacataag 2946061 ggttccaatt cttaatagcc tctgtatagc cggggtctcc tttgaagatt acacgccctg 2946121 tcaactgtgt tgatcccata tattatttca ctcccaaaga aattcgattc agatactaaa 2946181 atatgcagga gctggataat cgcatagaca aatgatctac gaactataaa tataatacgc 2946241 taaggccttt ttcgtcggtg aggtctgctg agaaacattt ttcaaacaat tttgagcaaa 2946301 cttcctgtcc aatcctccaa caagcgtttt ttcttatcgt ttttaggagc agtgtccagt 2946361 ttttttcgga gtgaatattc gtttaggcca aaagaaaaga gagatgaaga agtgtttagt 2946421 accagaggta tacatccata caacagactc tagatcatca tatactgaat gtatgtagaa 2946481 aggagacatc agctttggca aaatatcgga ttatgacctt tgacggcggc ggtaccttag 2946541 gtgctttaag tttacaacta ttaaacagat tggctaggca aaacccgaag ttaattagtc 2946601 gaacccatgt attttcggga aattcaatcg gttcatttac tgcccttgca ttagcaagcg 2946661 gaagatctcc gagggaaaca cttcagtatt ttgaggatga aatcctaccc gcattcagca 2946721 tttcccggcc aggcggacct gttttcaacc aacaattacc ctattccggt tttattaaag 2946781 cggtaagaaa ttttttccca gcagatcttc aacttataga tttaagaaaa cgaattgttg 2946841 tcccatcatt caaattatac tctcaaaaac tggaccgttg gactcctgtc ttatttcaca 2946901 attttcccgg ctctccctat ttaaatgaaa aagtgagtga tgtcatactg cggagcagcg 2946961 gtgctcccgc gacgcaacgc gcctatcaaa actatgtgga cggatatgta gtagcaacga 2947021 atcccagtac agccagtatc gcgtttgcag ttggtaaagc caacgtgcca ttggatcaaa 2947081 ttgcggtatt gtccatcgga acaggtgaag ccccgactcg gttaagaaga gatacgaggg 2947141 gatggggaat ggtaagtgca gataacatac gtcccgaaaa tctgaagaac cttcctccaa 2947201 attggggagt ccttttggac aggtcgccta atgaaccttt actgccattt cttcagatga 2947261 ttgctggcgg taatgggtac tatgaatcca tggtcagtgc gaatcttctg ggagatcgtt 2947321 ttttccggtt agatccgcgg attccgaact tctccaaaac ggaccctgcc gtcgttcccg 2947381 ctgtcattga aattgcgaac aaaacaaact tacagcctgc gaatcaattt atagagaaga 2947441 actgggggag caaataatta tttattttaa atcaattctc gcttatacaa ttttgtccga 2947501 gagaagattc tcaaaataaa tacaggcaat gggtagaacc ggattttttt aaaggtttgt 2947561 taatcacaag ctaataagat gaatgaaaaa atcaattcat acttcttctt ttgaaagtga 2947621 gggttcaaac taaagaatgt aattgaaatg ttactctaag gtatgcaatt ccctttttca 2947681 cacaaaaaaa gacaagagcg gcaaatcgcc aaacccttgt ctttcctgtt gttctattgg 2947741 acgcgctcgg agggattcga acccccgaca gacgtggtac cggaaaccac cgctctatcc 2947801 aactgagcta cgagcgcata tagactgcgt tatgagaacg tcagcacaac taattatacg 2947861 ataattcctt tcaaataaca accctctatt tcgagaggcc gttttttaaa tagacaaagc 2947921 atcttaattg gcaatctgac atacgatggt ttgaacccct gtatttttgg ggaaaatggg 2947981 aaaaagagac gactttgcat atcaggccag ctttttgttt gacctttatt gaccaaaaat 2948041 gtatcatgta actacatact tacctaaaag gtgaaggagg agcattatga atttaatacc 2948101 tacagtcatt gaacaaacga accgcgggga aagagcgtat gacatttatt ctcgtctatt 2948161 aaaggatcgt atcatcatgc ttggatctgc gattgatgac aacgttgcga actccatcgt 2948221 gtcacagctt ttattcttag cagcagaaga ccctgaaaaa gaaatttctc tttacatcaa 2948281 cagcccgggc ggctctatta cagccggtat ggcgatctat gataccatgc agtttattaa 2948341 gccgaaggta tctacaattt gtatcggtat ggctgcgtca atgggcgcgt tcctgcttgc 2948401 agccggcgaa aaaggcaaac gctatgcgct tccaaacagt gaagtcatga ttcaccagcc 2948461 tcttggcggt gcgcaaggtc aagcgacaga aattgaaatt gctgcgaaac gcattctctt 2948521 gcttcgcgac aaattaaaca aagtcctagc tgaacgtact ggccagccgc ttgaagtgat 2948581 cgaacgcgac acagaccgtg ataacttcaa gtctgctgaa gaagcgcttg aatacggcct 2948641 gattgacaaa attttgactc acacagaaga caaaaagtaa taacacaacc tgcaagagct 2948701 gcgtctcttg caggtttttt tcatttcaag gaattgactc ccttattcta tactgctccc 2948761 attcctcatg taacagctca agcgtcaaat cactcgtctg cctcacaacc agatcagcac 2948821 caagcatcgg ctgtccttga ccgacaccaa ccgcaaacat ccccgcagat ttgattgcag 2948881 aaatgcctgc ttctgcgtct tctattgccg cgcaatcagc aggggaaaca tcgagcatcg 2948941 ctgcagctgt taaaaagatg tcaggatcag gcttcccctt cgcaagagtc gtcggatcaa 2949001 caatggcatg aaaatcatcg ataattgcca agcgtcttaa aatcttagga gcattgcgac 2949061 ttgaagatgc taacccgatt tttatatttt cgtttttcaa ttgacataga agcctgccaa 2949121 tccccggtaa aagatcttcc ggcgtcaatt tgctgatcag catttgataa tcgcgatttt 2949181 tccgatgcat aagctcttgt ttctccgcat ttgtatactt tgtttccgcc ccgccaaaga 2949241 tcaatatgct ttcaagtgac tcttctctgc tgattccttt tagcctttca ttcatgtctc 2949301 tgtcaaaagg gatatcgatt tgttctgcga tgtgcttcca agcgagaaaa tgatattcag 2949361 cagtatctgt tatcactccg tctaaatcaa aaatgaccgc tttcatatac taatgcccat 2949421 cacagcttca taaggtttga ggctaatact ctttaagtca gcccgctcct gcggatagtt 2949481 tgaaattagc actttccaac gctcatgaat cagttctgga ggcgcttcga acagagcctt 2949541 ttcttccgat aaattcacaa cgacaagaag cttttcccct cgatattctc gaaggtaaga 2949601 aaagacctgc ggatcattct cctgcaacag ctgataatcg ccatatatca taatcttata 2949661 ttgctttcgt aattgaatga gcttctgata gtaaaagaaa atcgaatctt gatcttccaa 2949721 agactctttc acattgatat cttgatagcg ggaatttacc ggtatccacg ggtctccggc 2949781 tgtgaatccc gcatgttttc cggcatccca ctgcatcggt gttctcgcat gatcccttcc 2949841 ttttatcatc acggctttga caaactcttt ttctgacatc gttttgtttt cgacgactag 2949901 ttcacgatat gcattcttta tttcaagatc atcatacatc tccagcggca tatcgctgtt 2949961 gaccatgccg atttcttctc cctggtaaat aaacggcgtt cctttcatgc cgtgcagaac 2950021 cgttgcaaat gccttcgcac attccttacg cagtttcctg tcattgcccc agcgggaaat 2950081 aaccctcggc tggtcatggt tctcaaaata aagggtattc cagccgacat tcattaaccc 2950141 ggtctgccac cttgtcatcg tcttttttaa agcaatcaaa tcaaacggct tgatctgcca 2950201 tttcccattt ggcgagtttt gttctttatc aatatccata tgttcaaatg taaagatcat 2950261 attcagctct tgcctgcttg catctgtgta ctttttcgcc tcttcaatat cagagccgtt 2950321 tgcctctccg actgtcatgc agtcgtaatg agaaagcact tccctgttca tctcttgaat 2950381 aaactcatga agacgtgggc cgttagagtg ataacggccg acaatatagc tgcggctgtg 2950441 atccgtttcg tagtccggaa aatcggtgta tttagaaata gagccaatca catccatccg 2950501 ccagccgtca acgcctctat ccatccagaa tctcattaca tcataaactt cccggcgaac 2950561 ggcttcgttt tcccaattta aatcaggctg ttttttcgaa aagtagtgca aataatactg 2950621 ccctgttcct tcatcgtatg tccacgctga gcctgaaaag atcgatcccc aattattcgg 2950681 ctctgagccg tccggtttag gatctttcca aagataataa tcccggtaag gattgtcctt 2950741 cgacttgcgg ctttcagcaa accaagcatg ctcatctgat gtgtggttca cgaccaaatc 2950801 catgacgatt ttcattccgc gtttatggac ttcatcaatc agctgaaaca tatcttcatt 2950861 tgtcccaaac ttttcgtaca tgtttttgta atcgctgata tcatatccgt tgtcatcctg 2950921 cggggaatca aataccgggg agagccagat gacatccgcc ccgaggtttt tgatgtaatc 2950981 cagcttttga atcacacctt gcaaatctcc gaatccatct ccattggcat cataaaaact 2951041 gcgcgggtaa atttgataaa cgacagcttc tttccaccat tcactcatta ggcgttctcc 2951101 tttcacatcg tccctgtagg acaaccggtt cctcataaac gttcatgtgc agcggctcgc 2951161 cttttacaag ctcaaaaata acgcgctttt cgtcaaccgt cacattgatt aatcgatttc 2951221 gataattgat gttgaatgaa tattcgtccc attctttcgg caaaaacgga gcaaatgaca 2951281 gcgtctcatt cgcggtgcgc atgcctgcaa agccatgaac gattgccagc cagctacccg 2951341 tcattgaagt aatatgcaag ccttcttccg tatcatgatt gtaattatca agatcaagcc 2951401 ttgctgtgcg cttatataat tcgagcgctt tcttttccag cttgagttcg gctgcgagaa 2951461 tcgcatggac agagggcgat aggcttgatt catgaacagt catcggctca taaaattcaa 2951521 aatttcgccg tttttcttcc attgtaaaac ggtcattaaa aagataaatg ccttggagaa 2951581 catctgcctg cttaataaaa ttggagcgga gaatcttgtc ccatgaccaa ttctggtaaa 2951641 gaggccgttc cgctggatct aattcgtcaa ctgtttgcag gtctttgtcc aagaacgtgt 2951701 catgctgaac gaaaatttgc agttcttcac taaatggata gtacatgtgc tggatgattt 2951761 ctctccagac ttccaattct acttcctgca catccagatg gcggcgtttc tccgctgaga 2951821 tactttcgag actttgtaga gtatactcca acgtccaagc cgcaatgaca ttcgtatacc 2951881 aattgttgtt aacgttgttt tcgtattcat tcggccctgt gacgccatgg atcatatact 2951941 tattttttcg tttcgagaag tgaacacggt cggcccaaaa tctgctgact gccacaagta 2952001 cgtctatccc gtattcttcc atatagttac ggtcgcctgt ataattgata taattgtaga 2952061 tcgcataaca gatcgcgcca ttgcggtgaa tttcttcaaa ggtgatttcc cattcgttgt 2952121 ggcattcatc acctgtgaac gtcaccatcg gataaagtgc ccccttcatc cccaattttg 2952181 cagcgtttcg tttggcagcc tccaactgat gatagcgata caaaagcagg tttttcgtca 2952241 cctccggctc ggctgtcgcc aaatacatcg gaacggcgta cgcctcagta tcccaatatg 2952301 cggcacctcc atatttctcg ccagtaaatc ctttcggccc gatattcaaa cgggcatcgc 2952361 ccccgtaata tgtcgagaat aactgaaaga tattgtagcg gattccttgt tgaagctcct 2952421 catctccttt aatctcaatg tccgcttttg cccatctttc cttccatcga tcagtgtgcc 2952481 tccgttttgc atcttcatag ccgttctcta ccacatccgc caaaagctcc ttggctttcg 2952541 ataaaagctc ttcctcccga aaatcacggg aagtcgtgac aatcacaaac tttttcaatg 2952601 atgccttcgt ttgataactg tagcgattct cgacatacat ttcagtcgtt ttaaagcttt 2952661 catggacaaa accctccgtc tcgtttgcca ttgcggctaa taccgtgaag cgcggtgttc 2952721 caaatggatt ttcgatcgtt tttgccgcta aatggccgct gtgagaatca gcacctttcg 2952781 cttcctcctg ccaaaactgt tcttggtagt tagaatcttc atttgccaca tttccatcca 2952841 ggtaaggaac aagcgtaatg acagcatctc ccgtcaagca ctccgcttca taatgaatcg 2952901 cacagagttc ttttacagca aggctaagaa accgctctga cctgattctg acggttttat 2952961 cttgaatgcg gacaacagcg cttcgccgca gaatcccctc tttcatattg agttctacct 2953021 caaataattc gattgggttt tgatggagat cgattttttc accgtcaaca tataggccta 2953081 tgcccataaa gttcatcgca ttgatcactt ttccgaaata ttctggatac ccgtttttcc 2953141 accagcctac tcgcgttttg tcggggaacc acacgcctgc aatatatgtg ccttggtgac 2953201 tgtcgcctga atagccttct tcaaaattcc ctctgacccc catatagcca ttggcaagag 2953261 acgtcaggct ttccagcagc cgtgtatgct ccttattaaa tgtatttgtt ttgattttcc 2953321 attcatcaat ctcaaataac cgctgattta tcatcatttc ctcccgaatg taagtttcca 2953381 ttatcacggc gggttttggt caaatatcta aatgcaaaag agatcatcaa agtaacgcca 2953441 cacgaatgga tcatcaatac agtaatcaaa tcaaaatgaa ccatgccgat agcagctgcc 2953501 gcaaatgccg gcagtgctga tgcgcaaatc gctatagagg ccgcttcctt gaatgatgca 2953561 atagagacca tgtttgatat ttttgtgatc cagaggccac ctgcaagaac aaacgttaac 2953621 aaaagctgga tcatagaaac caccgtatat gccagcatca tgatcatcgg cttatactgt 2953681 gccaaccaca atgtatcgat caagacctct acatcatgga cgtttggttt ctcgagctta 2953741 acgtccattt tcgcatagcc aacagaaaac cccgtttcgt tttgatcggt gatcaccagt 2953801 tgatcaggtt gaaatatgat ggcgttttca aatccagtta ctttcaatcg cccattttca 2953861 ccgcttgtct catattcatg cttcatatcg actgccatca cattctgccc atcttcaatc 2953921 ctctcagagc tcttcccgcc tgttagtttt ccgttcctga tttgaaaacc ctgcaattga 2953981 tcagcaaatt gatcattaac tccttgaatc gctgacggca tgaaagatga aacgctgaag 2954041 cgatccattt tcacaaacga aaccgctaac ggcgccatta agcaggccgt taaaaacaga 2954101 aagagaaaag agagctgcag ccagctgaag gtattcccat agcggcaaac acctgatggg 2954161 gatgcagccg ccttcaggca gcggatgata aagcttttat tctccagatt cttcattggc 2954221 attacccctt tgttccgccg gctgtcaaac cggacacaaa gttcttttgg agaaaaaaga 2954281 atagaacgca tatcggcagt gcggctagta tggcaccggc tgcaaataga gctacttttt 2954341 gctgctgcgg attagaaata aaggattgta atcctacagc gatggtcagc ctttccggtg 2954401 agcgaagcag aaatttcgtc agcaaatagt cgccaaacgg tgccataaac gcccaaagcg 2954461 cttgtaccgc gagcattggc ttaacaagcg gtagaacaat tgaagcgaaa atcctcagat 2954521 gtcccgctcc gtcaattcgc gcggcttcat caatttctct cggcacagta tcaaaataac 2954581 ctttcatcag ccacgtgttc atcggaattc cgccgccgat atagatcgct gttaaaaacc 2954641 agtattgatc gagtgcgcct attagcatcg ccaagacata aaaagcagtc agcgccgcca 2954701 ttgtcggcac catttgaatg attaaaaaga atatcaggct cttttttctg cctgcaaacc 2954761 gatagcggct gtacgagtac ccggcaagtg tcacaatcgt aacctgcaaa accatgaccg 2954821 atagcgcgat gacaagtgta ttgctgtacc aattgagata aagcgtttcg tcaaatagcc 2954881 gcttaaaatg atccaatgtc caagaacccg aaaaatcgag ctgaaaagcc gccgaattcc 2954941 ccacacggaa ggctgatgat gccgtaatca gcaacggata tataatgaca atacttaaaa 2955001 gcgtcaaaaa taaatacgta cagattttat taagcattct ggcagtgctc gcgttcacct 2955061 acataacctc ctcattgcca aaagcattcg attttttgaa agcaatcagt gaaattccaa 2955121 tgacaatgaa agaaattaac agtgtcacag ccgccgcaac ggaatattgg ggtgatgtgc 2955181 ctgttgtcag tttataaatc cacgaaatta agatatcggt cgatccggcc ccggctcccg 2955241 cactgcctgg ccctccctca ttaaataaat agatgatcga gaaattattg aaattaaacg 2955301 tatactgagt aatcatcacg ggtgctgtgg caaataaaat catcgggaat gtaatatgcc 2955361 gaaaacgctg aataaaagtg gccccgtcaa tctttgccgc ttcatacaat tcacctggaa 2955421 tcgcctgaag cactcccgtt accatgacat atatatatgg aaagccgagc cacgtttgaa 2955481 tcataatgag ggctgtcttt gtccagaaag gatcggtctt ccacgcgatc gcaggcagct 2955541 cgacaaacgg caggtgattg aataatggta tcacctgtgc attcaccgct cctatgctgt 2955601 cgttaaacat gttggaaaaa ctcatgattg taataaacgc cggaacagcc catggaaata 2955661 agaaaatcat tcgaaatatc cgcttgcctt ttataaaatc ctgattgacg aaaagtgccg 2955721 tcacaatacc taaaatgatt tgcagcgttg ttgcacagat tgtccagata accgtccagc 2955781 ccagtacatt cacaaatgtt tcacgatagg agccaaggaa aaaaatattt aagaaatttt 2955841 taaacccgac ccagtcaatc agacgattag gcggaatatg ataaaaatca tagtttgtta 2955901 atgcaacaaa cagagtcacc aaaaccggaa aaataatcac aaacaccatc atgatatatg 2955961 ccggcagtgt aaatagatac ggaaaacctt tatcgcccgc atgacagatc atatccttgg 2956021 ctgttgtatt gacttccaaa cccgccgctt tcatagcggc ggtcttacgt gaatcatgaa 2956081 tattaaagat atagaacatg aggaaaatca ttgtcacgat caattgcagc gtgccttcaa 2956141 tcagcataaa cagcgagtga tcttcaccgg gaacacttcc caatgtcatc aatccggtta 2956201 gcgcctgtat accgaaaacg cataattcaa aagcaaacaa gcctgtgatg gcaagaaata 2956261 agagcccctt tgacaactgc tgattcgcaa tctgcccaag tcctggaatg atcgataaaa 2956321 gccctgcctt tcgtttttgc tttgtaagtg tgtgatgttt attcattttt ccgccctcta 2956381 ttcttccgga cgctatcccg ccgttttatt tcacatactt ttctttaata ttttccttta 2956441 tgacgtttac agcatcattc gctgatgttt gtgtcgattt ttttcctgaa gctgcatcaa 2956501 aaattaaact ttccgctcct gtccatactt cagccatttc cggaatattt ggagtcggcg 2956561 ttgctgtttc atattgttta atcacagctg acgtcagttc attcttttgc tcatcggctt 2956621 tcttccttgc agccgtgttg gccggaactt cgtttgtatc ctcataaaaa gcgtaagcat 2956681 tggcatcatt tgcagcatac tcaagccatt tttcagccag ctcgggctct tttgtatatt 2956741 tcgaggcaac ccagcccttc ccgccagcaa aaggggcgta ttcttctcca tttggcaatg 2956801 tcggaatggg agccgctccg tagttcaatt tagcctcttt atagttggca gctgaccaag 2956861 gaccgccaat gatcgcagcc gctttgcctt ctaaaaacat ctgctgaata aagtcgtctg 2956921 cgcttgaatt gtcttgcatt cctttcggcc aatatgtctc aaaccatttc tccgcatatt 2956981 tcaccgcttc tacagcccct ttattgttca ggccgatgtc cccggaatct gtgccgtttt 2957041 ttccaaacac atatccgccg tatccagcca ataagccgta cgacatataa aagtcagtcc 2957101 attttgctaa aaatccggtt gattttcctt tttccgaagc aaacgcgaat cgaggatctt 2957161 ccgttaactt ttcaaggtct ttaaatgttt ttggcgctgt ttttaaaaga tctttgttgt 2957221 aatacaaaat aagtgtctca atgactagcg gcattccgta cactttgccg tcaactgtca 2957281 cctgctgcat ttctttatca ccaaagcttt ttgtgttaga tggcttaata tcaagtaaat 2957341 gtccttgttg tcccaaaccg ccgatccggt catatgcagc aagcataaca tcaggcgcat 2957401 tacccgccgg gccatcaaga ggaagcgctt ctaactgttc gaacatttgc ttttcaacaa 2957461 tttttactgt gacatcattt tctttttcga actttgtttt tatgctttca atgtattctt 2957521 tatacgtttc ttcgacagac acagtcagca cctttttgcc atcagagctt gctggatttt 2957581 ttgaacttga gcaggcggca aggccgattg ccaggaatga tgccgccaat atggcgaacc 2957641 ccttttttaa aagaaccatc tcttttcctc cttctattta cgaaactata acaattgtat 2957701 tgtcctatag aaagcggtta caacaacttt cgatttgtta ccgataacag aatgttatac 2957761 aggggcggca gcactcaaaa tcaaaaattc tcccggctga acggcaatga catcgtgatg 2957821 ctgtagcggc tgctctgtcc atgcatcaca gattttctta ttcctatcaa tattcaactc 2957881 tcgtaaactg acgtgttgaa ccacattccc ttgattaaag aaataaatca gtattttttc 2957941 atcaagagtc cgcgaaaagc taatgaaatc atttttgtcg tccagcagat tccactcaag 2958001 atgtccttca gtcaataaag tgttttcctg cttgcgtaaa gcaattaacc gtttcataaa 2958061 ttgcagcatg tcttggtttt gcttctcttt ttcccaaacc atacatttcc ggcataatgg 2958121 atcattttcg ccgttcagcc cgatttccgt tccgtaataa atgcatggtg agcctgtctg 2958181 ggcaaacata aaggccagca acgcgcgtgc tttcttctca tcattgcggc atctggtcaa 2958241 aaggcgcttt gtatcatggc tatccagtaa attaaacatc acctcattgg cctgcttcat 2958301 tccattcatc aaatgtgcat tgacacggtg agccatacgt gaagctgaga tcgtctggtc 2958361 agcaaagtat tcaatcatag gctctgtaaa agggtaattc atcgccgcat gaaattcatc 2958421 ccctctaagc cagggttcgg cagaatgcca gatctcacct aaaatataaa catcaggctt 2958481 ttcagtagat acagcctgcc taaatgtctt ccaaaaaacg tgatccactt catttgcgac 2958541 atccaaacgc cagccgtcaa tgtcaaattc gcgaatccag tacaaagcaa tatcaagcaa 2958601 atatttctgc acctcgggat tagccgtgtt tagcttcggc atatcagctg taaaagcaaa 2958661 tctgtcataa ttgtcgtctg tgacgggaaa agagtgaata tggaaccagt ccttatagcg 2958721 ggattgatct ccgtttttga cgacatcctg ccattgcgga gacgcgcttc ctatatggtt 2958781 aaaaaccgca tcaagcataa ttctcatccc ccgctgatgc agctggctga ccaatgtacg 2958841 aaaaagctca ggatccccga aatgcggatc aatagaaaag taatccagcg tgtcgtattt 2958901 atgattagaa ggcgcggaaa agatcggtgt cagataaatg ccgttcaccc ctaaatcctc 2958961 taaataatca agcttgtcaa caattccttg taaatcccct ccaaaaaaat cattgacgtc 2959021 cgggtccttg ctcccccacg gcaatgcatt cttcggtgac aagtcttctc ttccatttgc 2959081 aaaacgctcc ggaaaaattt gataccaaac cgttgacttg acccattcag gcgcttgaaa 2959141 tgtatcagcc tcgtgaacaa acggaaattt aaagtaataa tgaatcgttt ccagtgtttt 2959201 ttcgttataa gggcatacac ccgaacttcc gaaaaagatg tcttcatgat cgtctgttac 2959261 aacaaacgca tattgtaaac gcctaaatgg cggcaccact tcagcaaacc aatagtcatg 2959321 catttctgta gcagcaattt tcctcatcgg ctgctcgttt gccgaccatt tgccgtcgtt 2959381 gtactcatag ggatcacccc aaatgaatcg aatgtgatct gcatcacctt ttttcgtccg 2959441 aatcttgata tgcacagtcc gcccatcata agaataagca tctgtgctga atggctggtg 2959501 atgaatcgct gcatattcca tcatgtttcc ccctttgatt tccgttttat tgaagccggc 2959561 tcatagtttg aaagtatcat gatgaaattg tgggaacaat ccttttcacc ctgttaccga 2959621 taacagaata aggcgcttac agcgttgatt ctcgtacaat taactctggt tcaaaaaata 2959681 gacttccttg tgcagcgccg tcttcattca tttttttcag caacattttc gcacaggctt 2959741 cccccatttc aacaacaggc tgtctgaccg tagtcaagcg cggcgaggag atgcgatcaa 2959801 gaaacacacc gtcattcccg gtaaccgcaa cgtcttctgg aattcgcttt ccaagggatt 2959861 gcgccgcacg aatgacgccg agcgcgattc gatcagatgc gcagacaaat gcggcctgat 2959921 tgtccatgga tttcagcagt tctcttgcaa ggcattcact tttcttagaa ctgttgtcga 2959981 tccgaaacat attcgatttt ttaaagcttt tattcatcgc ccgtatatac ccctgttctc 2960041 ttgcacgttc gaaaggctca tctaaatcaa tgccaaaaaa gacaacttcc cgctccccca 2960101 gccccataac atggcgggtt gccataaaag tgcctttctc gttattcaca tcgataaagt 2960161 catagcccat ttcattttgt ccaaatacga cgagcggctt ctcaaaagct tttattacac 2960221 cttcaaaatc gttctttctc aagccggtgg caataatgcc gtcacattgg ccaatattaa 2960281 gagaatttct tgtcacaagc tggagagcat agtgattgcg atccagctcc ctgctgattc 2960341 ctgtcagcag gttcatgtaa tatggttctg tcgtatccat ttcctcaagt atcaatagtt 2960401 tcacaacctg tgttctgttt tgcacgagcg ctctcgccgc ataattaggg atgtaattca 2960461 gctctttcat cgcagaatga acaagctttt tcaattcatc cgtcaccgtc tcagggtgat 2960521 tgatcactcg tgataccgtc attttcgaaa catttgcttt tttcgccaca tctgacaatg 2960581 ttgccatttt catcccctcc ttatctgtgc ttattatcca aactagtgat aaagtcctct 2960641 attactgcta aatatacgat gcaggccaaa gagaaataaa aaagagattt cccttaagga 2960701 aacctcactt tgttaaaaac actcgatttt tcatggattc atacgctagg tggcagactc 2960761 attctctcca cttccatcag aaaatctctt ttttaaattt ctgtccactt tttttctaaa 2960821 atcggataag aataattttg catttgctca attaactcat ccggccgtga cgagctgtga 2960881 atcagtttta ggtgcgattc gttagaaaac ccttcttgaa tgctgtattt caccattttc 2960941 atcattggtt caaaatatcc gtttacattg tacagtccaa ttggcttttg gtggatgccg 2961001 atctgtgccc agcacagcac ttcaaataat tcttcatatg taccgaagcc gcccggcatc 2961061 gagataaagc cgtccgccag ctcgctcatt ttagcctttc gttcatgcat cccgtttact 2961121 tcaatcagct cagtcagatt ctgatggaca acctccccgc tgaacaaacc gctcggcatg 2961181 accccgattg cagttccgcc gttttccata atcgcgtcag caatcgtgcc catcaagcct 2961241 acgcgggagc ccccatagac aaggccgatt ccctgctcag ccatatacac gccaagctct 2961301 gccgcttttc ttttatacgc ttcatttccc ccagggtttg atcccgcaaa tacacaaatg 2961361 gttttcatct tgtcatctcc gcatctatat atcgtgttaa acattcaaaa acacactata 2961421 tattgtccca tcttcatgtg ataatatcaa tatgaaatac ataaagaatg caggagtgat 2961481 gaggttgcag ctggctgatg cagaaaaatg gatgaaagag ttttacgaaa aaagaggctg 2961541 gacagaatac ggacctttta ttcgcgtcgg ctttttaatg gaggaagccg gagaactggc 2961601 ccgggctgtc agggcgtatg aaatcggcag agaccggccg gatgagaaag aatcgtcacg 2961661 cgctgagcaa aaacaagaat tgattgaaga aatgggagat gtcatcggaa atatcgccat 2961721 tcttgctgat atgtatggtg tctctttaga agacgtcatg aaggcccacc aagaaaaact 2961781 gacaaaacga tttgagcatg cataaaaaag cggccgcgat ggccgctttt tttaacctgt 2961841 gatttcatca tggtgatcaa agaaatgctg ctttcctatt ttgtgaaaaa ggcctgtttt 2961901 atgcagtagc tccttcggct gcgattgcaa tcctacaatc atcagctttc cattgtggcg 2961961 tttaattcga ttcataatgt tcccaagcac cgcttcagct gacgtatcca tatagtgcac 2962021 cttattcatg agcagaataa gggttttcgg ttttttctgt acatgctcca gcaatgacga 2962081 ttcaagggaa tcaattgatc cgaaaaacag cggcccttct atggcataca tgctgacaga 2962141 tggatcttct ctcttcgcca gaacaggatg cgtttcctga ttgtggatgc gggtcgcttc 2962201 gctcattctt ctgataaaga acacgaatgc aagcagcaat ccggttgcca caccgatgat 2962261 taagtcaaac agaaccgtaa gggcgaaggt cgccgccaaa ataaaggaat cagcattttt 2962321 cagtctcagc atgtttgcga cttccttgcg ctcactcata ttccatgcga ccaccatgag 2962381 aatcggtgcc atactggcga gcggcacatg ggacgcataa ggcgcaaata caagcaggac 2962441 aaggagaacg actacgccgt gaacgacgcc ggaaactggg gaaaccgctc cgttttttat 2962501 attggtcgcc gttctcgcaa tcgctcctgt agccgggatt ccgccaaaca ggggcgctgc 2962561 catattcgca atcccctggc cgacaagctc cttgttgctg tcatgctttg agcccttcat 2962621 gttatcagcg accattgcgg acaaaatcga ctcaagtcct ccaagaagcg cgatgacaag 2962681 cgcagccgga aacagcataa ccattttatc caaagtaagc tcaggaaact gaaattccgg 2962741 caaatggcgg gggatttctc cataagttga cccgatcgtt gccatgcggt cagggaaaaa 2962801 gacaaccgcg accactgtgg aaataagaag cgccaacaaa gcgcccggca ctttaggcat 2962861 caccttggcg gatacaagca aaatgacgag cccgatcaca gctgtcaaaa tggcatacac 2962921 gttaaaggtg ccgagctgct gcacaatttc aaacatgttg tgatgaaagt tctcatgttt 2962981 ttcaacattt ctcaatccga gaaaattagc gatttgttcc gtaaagatca gcacggcaat 2963041 tccggctgta aaaccgacga taacgggttt gggcacgaat ttcattattt ttccgagctt 2963101 aaacagccca aacagtacca gcatcactcc tgccataaac cccgcaatca gcagattttc 2963161 caagccgtac tgcatgataa tgccgaataa aatcgggaca aaggcgcccg tcggaccgcc 2963221 aatctgatat tttgatcctc caaacaaaga aatacaaatc cctgctataa caacagtgta 2963281 tagcccatat tcaggctcga ctcccgaggc aatggcaaac gccattccta aaggaattgc 2963341 cacgacacct actacgatac ctgcaatcaa gtctttctga aatttctgca aattgtatcc 2963401 cttgaatctc cctgagaatc gcatattttg ttataacctc ccttatgagt gattgtttat 2963461 aagctcagtt tcataaccgt taatgaccac atcaagtttt cctgtttcag ggtgaatgac 2963521 aagcccgtga accggcactt ttttcggaag cagcggatgg ttcttaatca tgttcacact 2963581 gtgggaaacg ctttcttcca cgctgtgaaa accagtcagc cacgttttca aatcgagtcc 2963641 ggcactcgtc agcaaattca ggcagctatc ctccaccccg cgttcctttg ctttctcaag 2963701 aatcgaggac gcattcagcc ctgacattcc gcattcatga tggccgacaa tgcatacctc 2963761 ttcagcctgc aattcataaa tcgcgaccag tatgcttcgc atcacgcttc caaatgggtg 2963821 agaaacgatg gctcccgcgt tttttacaat tttagcatca ccgtttttaa gccccattgc 2963881 ttgcggaaga agttctgtaa gccttgtatc catacaggtg acaatgacga gctttttcga 2963941 aggaaacttt gtcgttttgt acggttcata cttcttctca ctgacaaacc gctgattgtg 2964001 ttccaaaatt gatgttaaag aaaccatttg attcatctcc catccatatg attttgcaag 2964061 ccttcttacc cagcttacag taaggaatta tagcatagga ataagccaag aaaaggtttt 2964121 caaaaaaaga cactataatt ggactgtaga atcaaaacat aaacatttat atctttcaaa 2964181 gataataaaa tttatattta atgcatccta taatccggct gcagttcgta tatcgatgat 2964241 ttgtctgaca aaaaatatgg gtgaattctg ataattaaaa aactttttta agcagattta 2964301 gctgttcgat cttcatttta agttcaaaag aaccagaaat taaaaaaacg cagctatatt 2964361 tttaacatct atttattttc gatataatga attagacaac agccataaag ggggagcctt 2964421 gttgaaacca tttgtattta tcacaaaacc gattcctgaa gagattgaag cattcatcgg 2964481 tgaacattgc cgttatgaag tatggcagga ggatacgctt ccgagtgacg tgctatttga 2964541 aaaattaaaa gaagcggagg ggcttttaac atcagggacg tccggaccgt caatcaatcg 2964601 tgagttgctg gaacacgcgc ctaagctcaa agtggtcagc aaccaatcag taggctacga 2964661 taacttcgat atagaagcaa tgaaagaaag aggagtcgtc gggactcata caccttatac 2964721 actggatgac acagttgcag atctggcttt ttcactgatt ctgtcttccg ccagacgtgt 2964781 tgccgaactg gaccgttttg tcagagcagg aaaatgggga accgtggaag aggaagcgct 2964841 tttcggaatt gatgttcatc atcaaacgtt aggcattatc ggcatgggca gaattggaga 2964901 acaagcagcg agacgcgcca aatttggttt tgatatggaa gtgctttatc ataaccgaca 2964961 tcgcaaacaa gaaacagaag acagcatcgg cgttaagtat gcagagcttg atacattgct 2965021 ggagcaatct gattttattc ttctcattac gccgctgact gatgaaacct atcacatgat 2965081 aggagaacgc gaatttaagt tgatgaagaa ttcagcaatt ttcgtcaata tttcccgggg 2965141 aaagacagtt gatgaaaaag cactgattcg cgctcttcag gaaggctgga tcaggggagc 2965201 cggcttagat gtatacgaaa aagagcctgt cacccaagat aatccgctcc tgcagctgga 2965261 taatgtcacg ctgcttcctc atatcggttc agcaacagct aaagtgcgct tcaacatgtg 2965321 caaacaggcc gccgaaaata tgctcgcagc gatccaaggg caaacaccga aaaatcttac 2965381 aagagaattt caataaatca aaaatccggt ctgataacag accggatttc atattacata 2965441 cgctgaagaa cagcacgctt ataaatatga cgggtgacga tataataaag agcctggaat 2965501 acaaaataaa tgaagatgac aattacggcc tcaagaaata aattggaatt cagcatatta 2965561 cttaacgctg catacgcaaa gcccgcgtga atcgtacctg cgataaatgg gatgaagaat 2965621 aaaaatccta tttgctttcc aaggatcgag tgaatctctt tgtccgtaac ccctatcctc 2965681 tttaacgcta acacctgcac tcccgtatct tctatttccg taaacatccg caaatacagc 2965741 atgcttcctt gcacgataaa aaacagcacg ctgacaaaca gaccaataaa cagcattaat 2965801 gcaactccct gcttcacaat ttgataacta ggagcacgtg tttgaaaatc agatgtatgt 2965861 tctttcggca ccatgttttc aagcttttca gagacatcca ccgtctcctg ccaatgctca 2965921 agctcataac ctaccattct catctgttcc ttcagcggca catcctgtga cagactgtca 2965981 aagctctttt cgctgacaac caataaacgg ctgactccat cgacagacat caatatccct 2966041 ttgttttgct gctttttcat gacataggaa agggtttttc ctgacttcat atgaaatgct 2966101 gctgtttccc cttctccaaa tgtgtctttc accatcattt gaaaagaaac attaataaat 2966161 gcttcatttt cttgtaaatg aataactggg aacccttttt cctttgcgac ttgattatag 2966221 actttttctg aaatcagcaa agcttcagct tccatcttct tatttccata cggcaagtct 2966281 gactgaaaag tgacaggaat ccctgtggca tccaccttat acgtgataac agcatgagct 2966341 tttttcaatg tattctcagc cgtctcaggc ttcatgacct gaaagcggga agcatccttt 2966401 tccacccagg aaacagactg aggaatgctt tgctcctcct gcctttgtaa atcggaataa 2966461 aacatataga tgacacctgt agctgttagt atgaccgctg taatgacaga ggttaaaaac 2966521 agcatgcgtg catgatcctt cagcctgaat atcatgttgg aacgcacaat gatatttgtg 2966581 cctttgtaga agctgtgttt ctttcggtac agcatgcgga aaaatgccac actgctttgg 2966641 gtaaaaaaga aatacgtgcc aattaacact aaaatcaaaa ttggaaaaac ccgaaacatc 2966701 atgtcaattg cattggctgt tgcagataga taataaccgc tgccaagaca tagcaaagac 2966761 aatacagtga gccatttcga ataaactggc aaacttttcg gctttttggc tgatttaatc 2966821 agttcaatga tttccagctt ccgaatccgt cccagtgata aaatgagcag cgtctgaaac 2966881 aggatgagaa agccggcaat tgtcatcaca aacgctttcg gcacaatggc aaacgaaatc 2966941 ggcaccttca cgctgagcat ccatgtcatg atcataaaaa acagttttga aaataacagg 2967001 cctgctccaa tgccggccgc aatcgccgca agagaaataa gtgactgctc ataataaatc 2967061 atcttgcgaa gctgctgctt tgatgtgcca aacagtgtca gcagcccaaa ctctttcttt 2967121 cttgcctgca aaaacgctga attggaatat gtgatgaaaa atatacaaaa cacaatgatg 2967181 acgacaagag ctgcgctcaa gcatgttttg acaaggcttc ctccatatat attgtcttca 2967241 ttgacatcag gatgaaaaat aaatgatgtg aagacaaaaa acaccgaaac ggcaaacaca 2967301 cagcttaaaa agtaggccac ataccgttgc agattcccaa gaatgttttt acgggcgata 2967361 gttctcaaat tcatgaaaat cgcctcccaa cacactcaag gtatccaata tactttgata 2967421 aaacacctgc ctgtttgttc ctctgtgaat ctctgaaaag aaacgtccgt ctttaataaa 2967481 aacaatccgt ttacagaaac ttgctgctgt ggcatcatgc gtaaccaaca aaatcgtcgc 2967541 ttccttttcc tcattcagct gagccagtgt gttcatcact tgctttgccg attttgagtc 2967601 gaggtttcct gtcggttcat cggcaagaat gagcgccgga ttgtgaataa tcgctctggc 2967661 acaagctgcc cgctgctgct gtccgcccga cacctcatat gtgcggtgat cgagaatatg 2967721 ctttatttgc agcgtatccg ccagttcatc caatcgagct tccatttctc tcagctttac 2967781 cttatccaat gcgagcggca agagaatatt ttcacgaatc gtcagcgtat caagcagatt 2967841 aaaatcctga aagacgaagc cgagttctct tctgcgaaac aaagccagct cttggtcctt 2967901 taacgttttc ggctgaatgc cgttgatcat catctcgccc tgggtcggct tatcaatggt 2967961 agccagcaaa ttcaaaagcg tggtttttcc gcttcccgac ggccccataa tcccgacaaa 2968021 ttctcctttt gacacactga gatcaaaggc gctgagcgct tggtatgata ttgttccttt 2968081 atttgaatag tatgttttcg ataggttcgt tgtttgcaac acgttcatgt tctgctcctc 2968141 ctttttcttt attataaaaa ggaagtcagc atcctcccat cgaactttct tgcaattccg 2968201 ctccccaatc ttacaatgct gtcacattca cgagggtgtc acttgaaaac acgatggtca 2968261 tcacagtgcc agccccttct tttgattccg catacagctt atggccgaga cggctgcaca 2968321 cctgttttgc taaataaagg cccattccag ttgcctcttt catggttcgt ccgttttctc 2968381 cggtaaaaaa cgcgtcaaaa atccgcggca gatcctgcgg cggtatgccg attccttcgt 2968441 cggcaaccga caagcgcgtc tcatgtccct gtgtttcaat ccggattgta atagggtctc 2968501 ccacaccttg ctttgaatat tttaaggcgt tgaaaaggat ttgctcaaca acaaaggaaa 2968561 gccacttttg atcactggaa atctgaacgg catttggcgg cacatgtaat gttggaaaaa 2968621 ggcgccgctt gataaactga cgtttttcct gattgatcag tgaacgaacc atttctgcca 2968681 aatcaaaggt ttgcggcttt acatcaaatg caaattcctc cagccgggcc gtttgcagca 2968741 tcatatcaag accgtggcga aatctctcat tctcatcctc cagctcctct aaaaacgtcg 2968801 gaaaagagga tgaggttccg ttttttcctt cctgaatcat taaggatatg acagataccg 2968861 gtgttttcat atggtggacc cattggttgg tgaaggtgta atgctgtttt tgctgattga 2968921 tatattgtga gagcctgctt tcgtattgct gcccgagtgc gttgatcatc ttcgtccaaa 2968981 gcgcttgctc tcctgttctt ggctttctgg ctttcaaaga ctgtccgatg tcattcgaag 2969041 aagaggcttg ttctgcaagc tttttaacat atgtgagaaa ggaaaattgc cgaacataat 2969101 cagcagcaaa acctgcggct aaaagagtac cgggcaaaat ccatatgtac atcatatttt 2969161 ctttggaagg ttctgcgccg ctctctacaa tgcttaaata cgcaatcagc atggcggacc 2969221 ctatccctaa taatgaaaat agaataatgg ctaagcggtc gatgagataa gtctttaaca 2969281 ttccgcttca tccttccgat tgacttgaaa ttgataacct tgtcctctga ttgtggaaat 2969341 gcaatctgtc agtcctgcat tctccagttt tctccgcagc cgattgacat tgaccgttaa 2969401 cgtattgtca tcgacaaaat caacgtcatc ccataacgcc tccaatagtt catcacgaga 2969461 gacaattttt ttatgctccc tcacaaaaat cgagagaagc tggaattctt tttgggaaaa 2969521 caaaatccgg acgctgttcc attcggcctc attctgatca ggataaatcg tcagcccgcc 2969581 aagctccact attctagatt cctgcggcaa agagggcgaa tattcaccat atgtgcggcg 2969641 caggacgctt ttgattttgg ccatcactac ctctagatgg aacggctttg tgatataatc 2969701 atcgccgcca ttttcaatcg ccattacctg attcagctca tcggtccgtg ccgatataaa 2969761 gataatcggc gcattggaaa tggtacggat ttgcctgcac caataaaacc cgtcaaaaaa 2969821 aggcaggttg atatcaagca gcacaagatc aggcttcatt tctgcaaatt ccaattttat 2969881 atcattcagc tgttcagcaa ttttcacttc atatccgtat ttttgaagat gaccgcccag 2969941 caaagaagca atccgctcat catcttccac aagcaaaatc cgatacacgt tgatccccct 2970001 tatatgtaca tcacgatgat ttttctagaa gattccaaaa ttattatagc atgtgcggaa 2970061 tagtaaatcg gtctttttct ttttgttatg atagaatgat aaaggtaaaa ttttcataat 2970121 aggcaggtgt cgtgatgaag aaaatcatgc tgtttctggc aatgacgtca attctttcag 2970181 catgtcagcc caactatacc gggaaataca tagaaattgg ggatacacta actgactata 2970241 ccaaagagtg ctttaaagag aatgaaattc cttataaata cgaaaaggga aaactgtata 2970301 tcccagaaga cgcatttgat acagcaatct acacttgttc ataagaaaaa gcttgcagat 2970361 aacctgcaag cttttcacgt tacaaaaaat gagtatttaa tttctcttca aatcctgaag 2970421 ggccgatgtc gcttttttga atgttaccgc cgttttcata aatcgtaaaa tggcgctctg 2970481 acatgaccat ccttccgctc ggcgtcagct ttgaggcaag cagggatttg ttaaaaggag 2970541 atttttcatg agagtgaatg atgtccttca tgttatctaa atcaccgaga tcactctctt 2970601 caagggtaaa ggcgtaccca atttgccagc cttctccttt gtccatcagc agaacatagc 2970661 tgcccttttc tgtctcttcc tttttgattc ggaatgaccc gactggtgac tgtaccgttt 2970721 ctccggaaag cggtatcggc tggagcgcca ggttgatgcc gaagccgata tcaacgaggt 2970781 aatcgccgtt ttccgcagac agccatacag cagcatgcgt cccttctagt gcccatccct 2970841 cttgatcgcc tgcataaacc gttcctcgaa tgagcttcac atgaaacccg gcctcacgca 2970901 agacaaaata aaggaaacca tttagatcgt agcataggcc gccgtgctga tctttgagca 2970961 gacgtcgcca tagctcttct tttgtgatct tataattctc ttttgcaagt acggcacggt 2971021 tttcgaatgg aaaacggtat gccattgctt taagaaaaag gggaagatcg ccgaagctga 2971081 catggtcttt ctcccagccg attttctgaa agcagtcttt tagaaagtca ctcattttta 2971141 tcacctaaac ttcttcttga acgtaagcag ccagcttctc cagcgcctct tgttcatctt 2971201 ctccctgggc aatcaaggta acctcagtgc ctgtgcttac cgcaaggctc atcagcccca 2971261 tgatgctttt ggcgtttact tttttcccat ccttctcaag aaacacatct gacgtaaacc 2971321 ggtttgcttc ttgtacaaac aaagcagcag gacgtgcttg cagtcctgtc tttaatcgaa 2971381 cttccacttt ctgttgaacc ataagatctc cccttttctt tacggttatt ttaaagtgac 2971441 ggtttgccct gtccgcagct gttctgcgat ttcgtcaagt tttctcagcc tgtgattgat 2971501 ccctgatttg ctgattttcc cgcttgctac catttcccct agctctttca gcgtcacttc 2971561 ctgataatca atccgcagct gcgcaatttc ccgaagtttt tcaggcagcg cctccaggcc 2971621 gattctttca tcgatgtatt taatattttc cacctgtctc agcgatgcgc cgatcgtttt 2971681 gtttaagttg gctgtttcac aattgacgag gcggttgacc gaatttctca tgtcccgaac 2971741 gattctgaca tcctcaaatc gcagaagcga attgtgagcg ccaattacgt tcagaaactc 2971801 tgtaatcttt tcagcctctt ttaaataggt aatatagcct tttttccgtt caagcgtttt 2971861 gctgtttaac tgaaactcat ttaacaggtc acataatgaa tcgttatgct ccttataaag 2971921 agagaagatt tctaaatgat acgaggaggt ttccgggtta ttgaccgaac ctcctgccaa 2971981 aaatgctcct ctcatataag aacgcttgca gcatctcttt ttgaccagct ctttcgaaat 2972041 acttcgttca aacacaaaat tctccccgag tatttttaaa tcctctaaga tcgcttttgc 2972101 attttctgaa aaacgcacaa tatagacgtt attctttttc agccgcattt tctttctgac 2972161 cagcagctcg accgacacat catattgttt tttcagcaat gtatagatgc ggcgggcaat 2972221 cgccgcgttt tcggtttgaa catcgagtac gagatggcgg tttgtaaatg ataaagctcc 2972281 attcatccga atgagtgcag acagctcggc attaatgcag cagtccttca cttccagatt 2972341 cgttaattct ttttttgttt ctgatgcaaa tgacatatag ccacctcatt tcaaggcttc 2972401 attctttcag taaatcaaca agaagagagg ccactttatg tgtatcgtga cgtattacgt 2972461 catttttata cgttacaatt tgatctctga tgacttcaag ccccatcgct ttcagctctt 2972521 cgatatcaaa atcaacagga cgcgccgatt ccatttcgta cttacgtttt atttcgtcgg 2972581 gaatgtcttc actgttcact aatatcgtat caataaaacc acagcccata tgctgattga 2972641 gcgctttcac atgatcagca gcggtgtaat ggagcgtttc gccgggctga gtcatcacgt 2972701 tgcaaatgta tacttttttc gccggcgcct ttatcacttc ttccccgatt tttgggacga 2972761 gcaaattggg aagaatgctg gtatagaggc ttcccgggcc gataataatc aaatccgctt 2972821 ccctgattac gtctattgtt tccggcagcg gatcaatctg ttcaggcgtg agaaaaacac 2972881 gcttaatgcg ctgtccgtat tctgggatcg ttgactcgcc tgagaccacg cggccatctt 2972941 ccatctcagc atgcaaaacg acactggcat tggcagccgg caaaaccttt cctcttacat 2973001 tcagcacctt gctcatttct gtgacagcgt gaaaaaaatc accggttata tttgtcatcg 2973061 ctgccaaaat caaattcccg agagaatggc ctgttaagtc attcccttta ttgaagcggt 2973121 gctgaaaaag atcttcaaca agcggctcca catcggataa agcggcaagc acatttctga 2973181 tgtctccggg aggcggaatt ttcagttcat tccgcagacg gccagagctc cccccatcat 2973241 cggcaactgt tacaatggcc gtgatgtcaa cgggtttatg ctttaggccc cgaagcaata 2973301 cagaaagacc tgtaccgccg ccaaagattg cgattttcgg cttttgtccc atcttatttc 2973361 cggcttctct tttcaatgtc ccggtgagta acatgagtat agtaatcctt tttgaaataa 2973421 tcagctaaat tctcggctaa tgtcacagag cggtgctggc cccctgtgca gccgatcgca 2973481 atgacaacct ggctttttcc ttctcttttg taagatggaa gcataaagct cagcagatca 2973541 attaatttct cattgaactt ttgcgtttca ttccacttca tgacgtaaga ggaaacctct 2973601 ttatccttgc cagtcagcgg ccgcatgctt tcgatatagt acggattcgg caaaaatctg 2973661 acatcaaaga cgagatctgc atcaattgga ataccgtatt taaaaccaaa tgacatcaca 2973721 tttacggtaa atgtctctcc ttggtttgtc gcaaagtgct tcacgatttt ttcacgcaaa 2973781 tcacgcggct tcatgtcaga cgtatcgtaa atgatttgag agcggccttt taattcctca 2973841 agcagctctc gttctagcgc gatgccttca agcggcaggc cagtcgctgc cagcggatgc 2973901 gagcgtctcg tttctttata tcttgtgacg agaatggaat ccttcgcgtc caggaataaa 2973961 attcgcggtg tgatccacgg attttcggcc atttcatcca gcgcttcaat cagccggtca 2974021 aaaaattcgc ggccgcgcaa atccatcacg agcgcaactt tgctcatttt cgaatttgat 2974081 tccttcatca gctctaaaaa cttcggaagc aatgaaggcg gaagattatc gacgcagaaa 2974141 tagccgagat cttcaaagct ttggatcgcg acagttttcc ccgctcccga cattccagtt 2974201 ataatgacaa gctgaatatc atgtgattca ctaacactca tctttctccc ccctgacttg 2974261 tctttctatt tgatgtgctg cgggtctaaa cgataactga gcagctcaaa ttccggtgta 2974321 tacgtaaatg tgccgtgcag cagcccttgt cccttcatca taaaatcaag gatatggccg 2974381 tctccagggg ccataggcag gttctgaatg tcattgacat cgtgccactg cagtttgcct 2974441 tcctctgatt ctgatacatt ttgtcctgta tatgaatcag cgacaaacgt aaacatcatc 2974501 cactcggaga caatgtggtc accgtcttta ataataaagg taaaaacgcc ttttaattga 2974561 ggatttatga tatagatacc agtctcttct ctgtactctc tgatgacgga gtctctgact 2974621 gattctccgc tctccatctt gcctcccggc gcgacccacc atccgcgtct cggcttttga 2974681 agcagaagaa ctttgtcatc cgtctgaagc acacaatttg tcactctttg caagtacgtc 2974741 acctaacctt cgtcctgtca tcgtctcttt attataccgc ttcaagatgc ctcccacaat 2974801 gaagagacat tgacaatctt ttcttctatt ttacagcata ttcattcctt aattcagatg 2974861 attttgctgt aactggaatt ctcttttatt tatggacaaa aaaaggacac ggataactgg 2974921 agaatccgtg ccaaaaaagt gtattcatta taaaaagggg gtcaattact ttattaatca 2974981 taaccgaaaa gcattacaca tgtgttacag cggaattaaa acccagtaac gtaatgtgaa 2975041 actcgtatga cagccctttt tattttaagg ttttcagcgt ttcttggagc tcttcgacat 2975101 aatgttgtac gctttgtgcc gcaatgcttc cgtctcctgt agccgttacg atttggcgca 2975161 gtgatttttc gcggatgtct ccggcagcga aaatcccttc aaccttagtt tccatgcggt 2975221 cgtttgtttc gatatagcct tcttcattcg taatgcccag gttttcaaac ggtttagaca 2975281 gaggaagcat gccgatgtaa atgaatacgc cgtctgtttt gaattcactt tcttcaccgg 2975341 ttaccgtatc gacaagcgtt acgttaccga ctttgccgtt ttcctcatga atttccttca 2975401 cagttttgtt ccataggaag tcaacttttt cattatcaaa tgctctcgct tgaagaatac 2975461 tttgagcacg gagtttatca cgtctgtgaa caatcgttac ttttgaagcg aaacgagtca 2975521 gatatacgcc ttcttcaacc gcggaatctc cgccgccaac aacgacaagt tctttgcctt 2975581 taaagaaagc gccgtcacat actgcacaat aagatacacc gcgtccgccc aattcttttt 2975641 cgccaggcac gccgattttt ttatattccg cacctgcagc aatgatgaca gcacgggctt 2975701 tatattcctt tgaaccagct ttgactactt tgtactcttt gccgtcaatg acctctttaa 2975761 tatcgccata agcgtattca gcgccgaatt ttttcgcgtg ttcaaacatt ttgttagaaa 2975821 gctcaggccc aaggatactt tcgaatccag gatagttttc tacatcttcc gtattggcca 2975881 tttgtccgcc aggaattcct ctttcaatca ttaatgtcga taaattcgct cttgatgtgt 2975941 atacagcggc cgtcatccca gcagggcccg cgccgattat aatcacgtca taaatttttt 2976001 cttctgacac actattcact ccttaaacca tcttttcaag tttgggctct ttcttataag 2976061 ataagaatcc ccatcaaacg tattccttac ccatatccta taaaatctca tggtgatacg 2976121 ctattttttt gctcaacacg attaaatgta ttcgaaaagg gtatatgtta ataaagaaag 2976181 agccttctgt ttatagaagg cccttgtcat atttattatt gaacaacacg tcttacaaca 2976241 cctttaaatg ctgctttcca gtaaggattg ctcatagagt caacagatac gccatgagat 2976301 gtattgtcgt ttaggaaagt accgtttcct aagtagattc ctacgtgtcc atttgttttg 2976361 taagtgtcaa agaacacaag gtctccgcgt ttcatttcag acgcgctgac agcttgtcct 2976421 ctgccaacta acgtatcagt tgttgttccg cctacaggtc caaggttaac acctgcagaa 2976481 gcgtatgccc agcgtacgaa tgatgagcag tcaaaaatac ggttgttgat atcagactga 2976541 gtgcgtccgc cgccaaactt gtacggagat tgtcctacaa tgcttgaacc aacgctgatc 2976601 gcgccttcaa ttccgccaga gttgctgata acagtgccgc ctgaattgct gtttgagccg 2976661 ctgctcttct tagaagatga gccgtttgac gaactgtttg atgaaccgtt agaagaattg 2976721 tctgaagaat tgtctgaaga atcatcagat gagcttgctt ttgatgattc agttgtcgcc 2976781 gtttgactgt catctgtttg tgtttcatca gatgcttttt gtgcttcttc ctgctttttg 2976841 atcaaagcag ccgctgcttc ttgttctttt ttgatgcgtg cttgttcagc ttcagtattt 2976901 gctttttgat ttgcaagttc agacgcctct gattttaatt cagaaatcgc tttagccgtt 2976961 ttcttttggc ttgcttttgc ttcgtcgaaa agcttgtctt tttcattaag ctgtttatca 2977021 aggtcttttt gcattgtttc taatttagcc aaggcagctt gaacttcttt cagcttgtca 2977081 ttcaaatccg cttcagaatc ttcgagcttc gctttatcct gctcttgctg tttgattaaa 2977141 tctttgtctg cgtccacaat agatgaaacc gcagtcgcac gagagataaa gtcaccaaag 2977201 cttgttgatc ctaaaagaac atctatgtat ccttgagatc cgccgctttc ctgtaaagaa 2977261 cgaacgcgtt ttttcaggat ttcattgcgt ttttcgatgc gtgcttcagt ttctttaatc 2977321 tcttttttca gttttttgat ttcttctttt gttttatcgt tttcttcttt tttatcttca 2977381 atcttgttgc ttgtatcaag cgccttatcg ttaatgtctt tcagttcttt ttcaatcttt 2977441 gattgatttt cctgaagctc ggttaattct ttttccttcg cttcaatgct ggaagcaacc 2977501 tcagattgct tgctttcgat tttttgtttc ttttcatcta atgtttccgc cgatgcagtt 2977561 ttacttgtaa atgggatcaa aaaactgctt gtcccgatga cggaagccaa accaagtgta 2977621 attaaactct ttctcacttt ttatatcctc ccttttactg tgaacctgtc ctcatttgga 2977681 atcgtatttt gaacatcaag tttcgttcct catactctac gaggaatgat ggttgtttat 2977741 ggttaattat tctgtgcatc tcttattctg gttgtatagc gtttatttca catcatatgt 2977801 aaaaaacact aattccttat gtacgagaat cattatacca tcaagtttcg acaaattagc 2977861 gataaatttt attacattta tgtttcaaac agatgtcaag tcacacatca tttgtcattt 2977921 ttcttaagcg tgtaaaaaaa ctgtcgatat tattttctta atataatcta tctaacaaaa 2977981 aaagagtcga ttaaataaat caactcttta aaatttacta ttctagaata tcatcaatat 2978041 atttcatata tttcgtcaaa gttgccggag agatgccgaa tcgggccgct gtgtcttttt 2978101 tcgtgtcttg cttgccatgg gcttctttcc aaatataaca gatggctgct gcccagcctt 2978161 tctcattctt caacggagca gctgcacgaa tttgctggat gacatgaaaa acccagcagc 2978221 tcatgacttc tgttttcatc tcttcttttt cagcttgctc taatagtttg accgtttgat 2978281 aagcgaaaag tgcatcctct gaaacgtcag cagccgcaga atctccattc agaagcagct 2978341 ttacaaaatg agtttcaaaa ggagcggtaa ttctctttga gcgtatcacc gcttcaagat 2978401 gctctgtttc tccctttgtg ctgctgatat aataggctgc gagtcgctgc tccacagatg 2978461 aaggaagagc ttccctccgc tcaatccaag gcgccgggcg gtcttcgccg ggatattgcg 2978521 actcgacttt tctccagatc gtctcggcaa agtcggtatg tcccgtaaaa taagcagagc 2978581 aggaaagcca gtaaaagaag gtgtcgtcac cctcaaagcc ggttttatat aatgatttga 2978641 gccatttata tccgatctcg tagcggccga caagcgccaa agtagcaccc aatttataac 2978701 gctgctccaa tagcatcgga tagacattgg agagctgatc actcaattcc gccacttttt 2978761 cgtcttctct ttcataatag tagaaaacga gaagattgca taaggcgtga agatttcctt 2978821 cattatgaga aagcacttca taagcggttt gcttcgcttt tacaacgttt cctgaataga 2978881 aataggcaag cgcgagattg ttgtatgctg accaaagctc cggatattca gttgtgattt 2978941 cctcaagcgc cgcaaccgct tcagcaagct ggccgctttc cagcaatgac tttgcccgat 2979001 cctgtttcac cagcagttca tcctgatcat acaacgaatc ctcaatgccg tcgtctccta 2979061 aatcgagcaa atcaagcaga ctatcgtttt cttcggcgaa ttcaccatcc gggtccgcat 2979121 cagaataagc ggccgcttct ttataagctt cctggaagag ccccagatgg gcaaagttat 2979181 tcgctttaaa gtaatggcac tccggcattt cggcctccag atttgccatg atatagtcaa 2979241 gaagatcgtt cgactcttga tactggccca tttccgaata aatgaccgca agctgtgaaa 2979301 gcatctctga atcctccggc tccaaatgaa ccgcgcgctg aatcagtttg cttgcccgtt 2979361 ttagattgcg ctctttatac gctttcaagc ctttatgaaa aaaatattgt ccatcttgaa 2979421 gcagctggac aatttgtgcg tgatttttat gttcagaagt gtgttttccc acaactaccc 2979481 tccgttttat acaatattac cgtcagtagt ataccataaa tcgtaagccc ctcaatagtt 2979541 caaaaggaag gattgggaaa atccctcctc ttttttattg gctgattcga ccaaaattta 2979601 cccggctttg ttttctaagt ccgcattcat tttcagctgc tgttcagcaa aatcccggta 2979661 aaggccatgg gaagccatta actcatggtg tgttccacga ccggtaattt cccctttttc 2979721 aacaaacaaa agctggtccg catctacaac ggtagatagg cggtgagcga taacaatcgt 2979781 tgtgcggccc tccatcagca cctccagcgc ctgctgaact gatttttcag attggctgtc 2979841 gagacttgag gtagcttcat cgagcataag aatgcttggg ttacggagaa gcgctctcgc 2979901 aatcgcgatt ctttgccttt gtccgcctga cagcataatg ccgcgttcgc ccacttctgt 2979961 atcaaactga ttcggcagct cctttataaa attgagcgca tatgccatct ccgcggcttt 2980021 ttcgatctca gcatccgtca catctcgttc taacccgtag caaatatttt ctctgattgt 2980081 cccggacatt aacgggcttt cctgtgatac atacccgata tgctccctcc acgattcaag 2980141 cgagtaagta tcgaccggct cgtcccccag ccgaatggtc cctgcagtcg gagaataaaa 2980201 gcgttcaagc agcttaaaca gcgtcgtttt tcccccgccg ctcggaccga cgatcgctgt 2980261 cactttccct gcttcaatga cggcgctgac ctcttttaag atcagctgat caggcttata 2980321 tccaaaagac acgcgatcaa gctggatagg cagatgtgca ttttcaattt gttttcctgt 2980381 cactgtatct tcctcttcct ctgccaaaat ctcaatcatt cgttctgttg caccgattga 2980441 tttttgcagc tgtgtgaaaa acgttgtaat ctggcccatc ggcataataa tttgaaacaa 2980501 atataaaata aaagccacga gcgctccggc tgtgagctcg cctgatgaga cctgcatgcc 2980561 gccatatccg atcactgcga caagcgctgc cattaacacg agtgaaataa gcgggccgac 2980621 aagcgattga accttggctt cacgaacgcc aagcttaaat aatgaggaaa tccccatctt 2980681 cccgcgccca tattcgacat cctccgcatt tgaagcctta acaagtctga tttccgggag 2980741 aatttgatta agcaggcctg taaaacgagc cgtttcatct tgcgtttccc gtgaaatgga 2980801 gaacattttc cgtccaatcg gcaccaaaat aagagcggcc agcggaacga ccactaacac 2980861 aagcagtgtc agcttccagt tcataataaa caagattgtc aatgatccaa tgacagaaat 2980921 gatgcctgta ataaatccgc tgatatgggt tgtaatcaat tctttgacca ccatcgtatc 2980981 gttcgttaca cggctgactg tttctccgga agcatttgta tcgaaataag agacaggcag 2981041 cttaattaat ttcttccata ataactcccg cagcccggaa atgatttttt gtccattata 2981101 gttaagcgca taggtggcat aagcgcttaa acccgcctga acgaaaaaca ccagcgcgat 2981161 caaaccgatt tgcgtgcctg acagatttga catagaaaaa ccatcgacaa gctgcttcgt 2981221 taataatgga atgagcaggc tgaccagcgt ggttactaca ctgagggcaa gcgcaaaggc 2981281 gagctttcca taagaaggat tggtccgtct tactaaggca aaaaagggtt tcaatttact 2981341 tttagatttt tgtttcttgg ttggcatata ttttcctcct gtttcagcgt tcagaaaggt 2981401 gaaaagtcat agcaaaagga tgatttttac tctttctcaa tcatatcaat ggagaaagac 2981461 tttttcagta tatttttgcc gtgatcaaaa taaaaatctc ccactcattg tttgaatagg 2981521 agatttttgt gttagacatc tttcactggc ttcttttttc tgtaagtcaa tgttacatcc 2981581 tgctgtcgca ggtcttctat tatcattttg taccgatcaa cttttgcggt atgttcttct 2981641 tttatcatct gaagggcagc ttttcgtttt tcgctattag actcaagctc tttttttatt 2981701 ttttttacaa tcaacccttt ttgccctttg atttcctctt ttaatgaaga ctcaaatttc 2981761 tttgtcaggc tgagaaagtc gttgatcggt tgattgaggg tgcccgcttt ccccttcatt 2981821 tcatcttggg taagaaacat ataggtcgtt gatacaattt ctgtttcact ttctgaaaat 2981881 aaggaagtca ctcttcatat tcctcctaag actgaaaatc aaataactga gaaatcattt 2981941 cttctttttc aaacagcttt tcaatactct cgcggatatt tttgataaaa tctctttttt 2982001 ctgttgtctg tttttttaat tcagcaacaa ttccatcatt tgcaggaagc gcacctgtgt 2982061 ggaatgattc atgaactgag attttctcca atttatcgaa tgtgtggctg aaaccagctg 2982121 caagccggaa ttgaagatcg aaggcataat gcgaagggtt ttcttccata tgatgaatag 2982181 ccgtgatgat cgcctgcttt ttgtctatga agtcttcatc gatttcctga ctgtaaacct 2982241 tctggtactt agaaatcgca tcttccatat cttcaacgat tttcataccg ttttgataga 2982301 ttctgacagc ggatgagaga ttgacttgaa tcgtttctcc cgagccactc ttccctgtaa 2982361 aataaatatc ggagccttta tagctgaagc ctttttcctt tgacaaggcg ttgagcattt 2982421 gaacgatgct gtggccgtcg acgataagtt ttagtgcgtc ttttgtttct gtgtcgagtg 2982481 ttttcaatga ggacagaatt gattttacat agtccactat ttcaccaacg tcttttaaag 2982541 cttgcataaa ttggccatgt tttagatggt ctatgaaatg ttcgtaccgt gactctatgc 2982601 ctcgcatact cgcattaata ttcgttaatt cttttttgat gactttcttt tgcgtttcat 2982661 caatataacc attttcagct aactgatcta cgaccggtcc gctgtttctc aacaaggtat 2982721 gaagaaaacc taaaaacgac ggcagttcct cttttattcg gccatacatt tgcttaacat 2982781 catcaaaatg ctcatatagg acacttactt tctttaaagc gccgtctgtg tttttcactt 2982841 tttcaatcag gtctatgtct atcccgctgg ctgcctttat aaaaccgttc aagccgtctt 2982901 tttcatagtc atccttatat ttttgaagga atttttgaat tgacctcaca tcttcgtcag 2982961 gaaccccatc cataatgttt cggatgcctt ttacacttgt atttgtatct gccatcttca 2983021 catcaccgaa tgtaataaaa tcggccttgc cgctgactcc atacagcggg tcatcttttg 2983081 agatgcgctg agtgatgttt gttgttacgc ctttgtcttc ataatatttt tggatttctt 2983141 tttttaactt ttctggcggg atggaatcta tatcttcata tttataacta aatttcctaa 2983201 taacatatct atataaactt tcatcagttt caagtaattg atcaatattg acttgagctc 2983261 catttacccc ataaacttca tcatattctc catcaatcaa ttgcaccata acttggttat 2983321 tatttgcaag tgaatgtcct aaggcgaatg tttttaaatc ctcagagtta cctgctgctt 2983381 tctttgcttt gttagtaaac tcctttgtag cctcatactg actatgatca attcctaaaa 2983441 aaagaccaaa aaagttatat gaccaatcct tattatcggc actaccttct gaaataatct 2983501 gaagctgatc aatatgtttt ttctcatcta ttatatggat tgccgttcca tcgtaacctg 2983561 attctctggt cgaactttgt atacttgtat tctgatttac aagttcattg gaggtgtaaa 2983621 tttcaatttt catattctca ggaagatcgt ggtgggtttc ctctttataa attctgcgta 2983681 tatctgcttc gaaatccttc ttagctttct taacttcact cgcaatagtt gaggcaaact 2983741 tttgtttata gtcatattct aaatcaatta accttaactt tacgttctca ttctcaaata 2983801 catttttatt tcccatctta tttctccttt ttatctatta aaaaggtgat agaattaatt 2983861 aatttctcaa ctttattttt agccttttct tcatctaagg agcatggttg attttcattt 2983921 ttgcatccaa gggtaaaggc gtattctact cctaggttat cttcctctgt agacttaaca 2983981 tatccaaaat aactgtatga ataattatat tttctatcaa tatcgtcaaa gatgtctttt 2984041 ttcttggcag tgtaaatatc cgttttcttt ttgctgcttt ttttgtattc gcctttataa 2984101 tcattttttc cactaacaat atctagcatt gtcttaggtt cattcgcaaa actttcttct 2984161 ttgtaatatg ttacatggcc atcaaacatt acattggtgt ctttatcata actattaaat 2984221 ccaatacttt ctttgttttt cccggttaac gatgatcttc ttgatagata ctttccatcc 2984281 tccggaaaca acatcctaaa ccctttcagc ttagattcca gcaaataata tcctggttcc 2984341 tcttcttttg ttgacaccat gtactctctc gttttctcgt cctgaaacgc aggtacttga 2984401 ggcagatcct tgggatccat gtcttttggt tttaccgctt ctgttttatt gtcatttgtg 2984461 ctgtttttat cattgtcatt catactgcat cctcctgtca gggcaagtaa taagctgaag 2984521 caaataaaga tgatcttttt cattacgaac ctccacgggt tttgtgagaa tagtattcta 2984581 tttttatatc aaaaataatt ctattgacct ggttaagaga tgattatttc atcctttttc 2984641 atgttacatc atggcggaat ttggataaat aggaaatgag actcggtttt gatctccttt 2984701 tattaactaa tcatatataa cacccaatat aaatctaaat acctattact tttttcacaa 2984761 aacaaaaaga gccgtatcat ccggctcttt actcttcaat ctcagaatgg cgttttttca 2984821 atacgtcaag cacatcatcc agcggcaggg attgttctct gagcaggaca agcaggtgat 2984881 acagcaggtc tgccgcttcc catttgagtt cctcatgatc ccggtttttc gcggcgatga 2984941 tgacttcgga tgcttcttct ccgacttttt tcaaaatctt atcgacgcct tcacggaaga 2985001 ggtacgtggt gtaagctcct tcaggcattt ccgcttggcg ttccgcgatc acccgctcca 2985061 gttcgttcat gatgccgaat cggtccgcgg cctgttcttc tgtttgttcc tttgtaaaac 2985121 agctgtagct gccagtgtgg catgccgggc ctgacggttc tacgagtacg agcagcgcgt 2985181 cttgatcgca gtcataccgg atacctttga cggcttgcgt gttccctgag gtttctcctt 2985241 tatgccataa cgcttggcgt gagcggctgt aaaaccatgt ttccttcgtt tccagcgttt 2985301 tttcgtacga ttccttgttc atatacgcaa gtgtcagcac ttctttgctt gccgcatcct 2985361 gcacgatagc aggaattaat ccgtcctcgt taaaacgcag ttcatctgcc tgtttcatct 2985421 cacattcacc ccgtactctt tcaagtatga tttcacttct ttaatcgatg tttctttata 2985481 atgaaaaatt gaggcggcca gcgcggcgtc ggcttctcct tttgtaaaag cctcaagcat 2985541 atgctgtgcg tttcccgcgc ctcccgaagc gataacaggg acggggacag cttcggaaac 2985601 aagctttgtc agcgtgtggt cgaaaccttt tttctcaccg tcggagtcca tgcttgtcag 2985661 caatatttct cctgccccgc gtttgacgcc ttcttttgcc cacgcggtga cctcccaatc 2985721 tgttttcttt ctgccgccgt gcgtgtagac cttatatgtg tcagattctt tgtcatactt 2985781 ggcatcaatg gcaagtacga tgcattgaga accgaaaaac tcggctcctt ctgtaatcag 2985841 ctcagggcgg agaacagctg ccgtgttcac cgacactttg tccgctccgg cacgcagtat 2985901 cgttttcata tcgctgagct gattgatgcc gccgccgact gtaaacggaa tggcaagctt 2985961 cgcggcaacc tgctccacaa cgtcaaccat cgtctttcgt ccttcgtgcg aggcggagat 2986021 atcaagaaaa acaagttcat ccgcaccttc ccggtcgtac acttcggcga gttcaactgg 2986081 gtcaccggca tccttcaatt cgagaaattg aattcctttg acaacgcgtc cttctttgac 2986141 atcaaggcat gggataatcc gttttgtgat catttgcgct tcaccctttc aagcgcctca 2986201 ctcagcgtaa actgattggt atacagcgct tttccgatga tcgctccaga gacgccgtcc 2986261 gcctcattgc gggcgagagc ttcgagatcc gcgacggagc tgactccgcc ggaagcgatc 2986321 accgatttcc ccgtttcctt agcaagctcg accgtgcttt taacattggg gcctgacagc 2986381 attccatctg tcgcgatgtc agtaaaaata aagacttccg caccttcatt ggctagctct 2986441 ttgcccagtt cagttgcctt aagggttgat gtttcaagcc atccctctgt tgaaacaaaa 2986501 ccgtttctcg catccagtcc gattgcaatt ttctcgccat attgtttcag catttttttg 2986561 acaaacggag ggttagaaac tgctgagctt cccaggatca cccgctcgac tcctgctgat 2986621 aaatattcat agacgtcatt ttcagaacgg atcccaccgc cgatttcgac tttcaggttc 2986681 agcttttgcg caatctcaat cacatggcgg tcattcactc ttttcccttc tttggccccg 2986741 tcgagatcaa cgagatggat ccattcggca ccctctttct caaataactc agccatgtcg 2986801 tacggtgaat cgccatatat cgtttcctta ttataatccc cttgaacaag gcgaacacat 2986861 ttgccgtttc tcatatcaat tgccggatat aatgtaaaag cactcatttt ttcaccttct 2986921 gttctgctgc cattttcgta aattgggtta aaatagacat tccgaccgtg ctgctttttt 2986981 ccggatgaaa ttgggcgccg aagacgtttc tttttccgac tacagcaggc actcgtacac 2987041 cataatcggc gcttgccaga agcgcgttct cctccatccc gtcaatgtaa taggaatgaa 2987101 cgaagtaagc gtagccttgt tctgttttag tcagcagcgg agattcatta tgaaaagaaa 2987161 gacgattcca gcccatatgc ggaaccttca gcttgtttcc tttttcatct tctgctttca 2987221 gcctgactgc ttttcctttt aacagcccga gtcctgaagc ggtgccgttt tcttcgcttt 2987281 cttcaaataa aagctgcatg ccgaggcaga tcccgagaag cagccttccc tctgagacca 2987341 tatcgtgaat caattgatca agcttcgtgt agcccaaatt gtccatcgcg tctccaaatg 2987401 aaccgactcc cggcaaaatg aaagcatcag cttctttcag ctcctccggc ttttcagaaa 2987461 caaaatacgg cacgccgaca cgttcaagcg cctttgagac actgtataaa ttccccattc 2987521 cgtaatctat cacgccgatc atttacagca tccctttcgt tgacggtatt cctttaactc 2987581 gcggatcgat cgttgtcgct tcatcaagcg cacgtcccag tgctttaaaa acggcttcaa 2987641 tcatgtggtg ggtatttgtt ccataatgaa cgatgacgtg caggttcatt cgagcttcga 2987701 gcgccagctt ccacaaaaat tcatgtacaa gctccgtatc gaaagttccg actttagcag 2987761 ccgggaaatc agcgcgcatt tctaagtgcg gccggttgct taaatcaatc acaacttgag 2987821 caagtgcctc atccatcggc acaaacgccg atccgtagcg tttgattcct tttttatcgc 2987881 ccaacgcttc gagcagcgcc tgccctaagc agatgccgat atcttcagtc gtgtggtgat 2987941 catctatatc aacatcgcct tttgcgttaa tggaaagatc aaattggccg tgtttcgtga 2988001 ataaatccaa catatgtgtc ataaacggca catctgtttt aatatccgct tgtcctccgc 2988061 cgtctattgt aaatgccagc tcaatatctg tttcgtttgt tttcctgacg cgttccgctt 2988121 ttctcattta gaaatcctcc gttctctcgc ttcaattgat ctggcatggg cttctaaccc 2988181 ttccagtctg gcaaaagccg cgatgctttc ggcatgttct tcaaaggctg attgactgta 2988241 agaaataatg ctcgatttct tttgaaaatc agttacgttt aatggacttg aaaatctggc 2988301 tgttccgttt gtcggaagca catggttcgg tccggcaaaa taatcaccga caggctcagg 2988361 gctgtatctg cctaagaaaa ttgcacccgc atgtttgata ctgccaagca aagcttccgg 2988421 agactgtgtt atgatttcta aatgctctgg cgcgagtgta ttgacagtct caatcgcttc 2988481 taccattgtt tccgccacat atatacaacc gtaatctctc actgaagctt ccgctatttc 2988541 tcttcgcggc aaggtttcca gctgcttatt cacctcggct gaaaccgtct cggccagcgc 2988601 catggaatct gtgacaaaca cacatgagct aagcttatcg tgttccgcct gtgacagcag 2988661 atcggctgca atttcgctcg gaatcgctgt ttcatcagcc agcacgacga tttcactcgg 2988721 tccggcaatc atatcgatat cgacatcgcc gaacacttct cgtttggcaa gcgcgacata 2988781 aatgttgccc ggacccgtga ttttatccac cggctcaatg gtttctgttc cgtatgctaa 2988841 cgccgcaatc gcctgagcgc cgcccatttt gtaaatgtct tttatgccca gctcggctgc 2988901 agcaaccaaa actccaggag acagcagacc gtcttttccc ggaggcgtga cgagaacgat 2988961 tctttcaacg cccgctacga gcgccggaat cacattcatc aaaacagatg aaggatatgc 2989021 ggccgttccc cccggcacat atacaccggc ggaatccagc gccgtcactt tctgccccag 2989081 cattgtgccg tcctttctgt gataaaacca ggaggattgc agctgtcttt cgtgatattc 2989141 cctaatattt tcgattgcct gcctaatcac ctgaagaaga cgtgaatcca gtgaggtgta 2989201 tgcctcctca aattcttctt ttgtgaccag cgggctgtct atttcgatgc agtcaaattt 2989261 cgccgtgtag ctgcgaaccg cctgatcacc gtttgcttta acatcttcaa taatggaccg 2989321 gaccgtcttt ctttgctctt ccgttccggc atcgatggaa cgcttgagag aaagccgttc 2989381 cgctccgctg atggttttga tcttcatttt gccgtctctc cttccacaac gagagatagg 2989441 cgggatgcca tttcgtcaat cacatcgtct ttcatgcgat agcttaccgg gttgacaata 2989501 aagcgagagg taatgtcaca aatgtgctcc gtttcaacaa gcccattttc tttcagcgtc 2989561 tgtcctgtgg aaacaatgtc cactatccga tctgcaagcc caatgagcgg agccagttca 2989621 attgaaccgt tgagcttaat aatctcgact tgttctccct gctctctgaa ataactggaa 2989681 gccacattcg gatactttgt cgcgattctt ggcgctactc cgctccagtc tgtattcgga 2989741 agtccggcga cagctaagtg gcatttgctg atgtttaaat ccagtacctc atacacatcg 2989801 cgttcctcct ccagcatgac atccttgccc gcaattccga cgtctgccac gccatgctcc 2989861 acatacgtgg ttacgtccat cggcttcgct aatataaacc gaagattttc ctccggcaca 2989921 tcgatgatca gttttctcga atcttcaaac tcctcaggga gcctgtagcc tgcctgcctc 2989981 agcagccctg ccgcttcttc aaatatccgg ccctttggca tcgccattgt gagtaactta 2990041 cccattttgc tcttcctttc tggcaccgat aaaataagtg acgtttgcaa aagattttgt 2990101 catctggtcg atattttcta ttcccgataa atcttgaaga accactttgt tccctttcat 2990161 gcgttcttca ttcgcataag cgatggcttg cgcccgctgc tctttgctga aaataacagc 2990221 gtctatttca caaggttcgt ccttcatatg aagggcttca atcagccggt cgatccgaag 2990281 cccgaagcct gttgccggtg caggtgaatc aaaatggccc agcagcttgt tgtaacggcc 2990341 gccgcttcca atgacaaaac cgacattctc ggcgtacact tcaaataaaa tccctgtgta 2990401 atagctcatg tggctgacca tattcagatc caggcggaca ttttccgtac atccgtaatc 2990461 ctcaagaatg tcccacagcg ccttcagctc atcaaccacg ctttttcctt gcgcagaatc 2990521 gacgatttcc tcggcacgtc cgcatacttc tataccgccc cgcagttcaa ggagctcaag 2990581 cagcctgctt ttatcaatgg aggaaagcgg gagagacttg acatgctctc tgtagccgac 2990641 gtagttcttt tcatataaga acctccgcag cacatcagct cgttcaacgt ttccgagcac 2990701 ctcaacaaac aaagcatccg caatgccggc atggccaatt gcaattttaa aggatgccag 2990761 cccagcgttt tttaatgccc cgacgactaa agcaatgacc tccgcatccg cgctcgtcgt 2990821 gccgtcaccg attaactcca ctccgacctg ctcgaactca gccggacgtc cgccttcacg 2990881 ctcctgagcc ctgaatacat ttgccgcata gccgactctt agcggatgac cgtgtttcag 2990941 aagcttcgat gccgccaccc ttgcaatcgg ccccgtcata tccgggcgaa gcaccaatgt 2991001 cttgccgtcc tgatcaagta gcttaaacag ctgctgctct tcaattgctg actggacgcc 2991061 aacggtatcg taaaactcca gtgtcggcgt ttccataaat tgatatcccc atttatcaat 2991121 caaatcggtt aacgatcgtc tcaccttttt tttcgtttcg tataaaccgg gcagtgtatc 2991181 tctcatgccg tgcggttttt caaacataaa catcaacccg agcacctccg ctgttatctt 2991241 atgaaggaaa attccgaatc ctttagttcg ctaatatgat aatatgttag cagatgaaag 2991301 aatgaaaatc aacgcttaac ttcagtaagg atatttttag ttcaaatatc cttctcctca 2991361 ttatgaaaaa atcatgaata atgtattaaa ggtacgtaat atctcaaatt ctttatgttt 2991421 ggcatgctat aatacaaatc aaatagagaa caaggagata aagatgaaaa cactgcgaac 2991481 tctatgtgtc ctgatgattc tttcaggcgt tatttttttc ggacttaaaa tagatgcaaa 2991541 agatatagat attccttttt tgaacagcct taaaaaagtg gtttctgata gcgatacaga 2991601 ctcagctgcg aatagcaaaa aggagctgaa gggaagcgca aaaccgctgg atgtcatcct 2991661 ttacaatcaa atggacgcac cccggctcta taacggctgt gaagtaacaa gccttgcgat 2991721 ggtgctgaat tatgcgggat acgacgtgac aaaaaatacc ctggcaaatc aggttgccac 2991781 agtgcctttg acatacagca gcggattaaa gggtgatccg aatgacggat ttgtcgggga 2991841 tatggcgaat ggccctggtc tcggtgtcta ccatcgaccg atctatcagc tggcgaaaac 2991901 ctatgcggga gacaaagtgt ctgatctgac tggaaaaagt atttccgctg tttatcagca 2991961 gcttgaaaaa ggcaatccag tttgggttat tacgacagcc aactttacgc cagttgacaa 2992021 catgcagaca tggaaaacgc caaacggaac gatagaaatt acgtacagcg aacacagcgt 2992081 cgccgttacg ggatatgatg ataaatatgt gtatctcaat gatccgtatg gctataaaaa 2992141 cagaaaaacc gatagaacaa gctttgaaaa agcgtggaaa caaatgggca gccaggccgt 2992201 ggttattcaa aagtaaacac ctgaagcctc actatgctct attctgagca aatacgacaa 2992261 tattcatgct ttttgtatca atcggtaaga tcgattcatt ttccattttt cacccaaaat 2992321 tgtctttact ttcaggctgt ctgtttttat gattaaagca gattcagcct tgccccgatc 2992381 tatgcgagag aagccggtgc aagtcgctga cgcttctctt gcaaaaaatg aaagatatcc 2992441 ggggaggatt tatcattgaa aaaaatcgtg tctatcctat ttatgttcgg tttggttatg 2992501 ggtttcagcc agtttcagcc atcaaccgtt tttgcagctg acaaagtggt gcacgaaaca 2992561 attatcgtac caaaaaatac aacatatgac gggaaaggac agcggtttgt ggcagggaaa 2992621 gaattaggtg acggaagcca gtcagaaaac caagaccctg tttttcgtgt ggaggatgga 2992681 gcaaccctga aaaatgtggt gcttggtgca cctgcagctg atggcgtgca cacttatgga 2992741 aacgttaaca ttcagaatgt gaaatgggaa gatgttggtg aggatgcgtt aacggtgaag 2992801 aaggaaggaa aagtgacgat cgacggcggt tctgctcaaa aagcgtcaga taagatattc 2992861 caaatcaata aagccagtac cttcacagtg aaaaatttca cggcggataa tggcgggaag 2992921 ttcattagac agcttggtgg ttcaaccttc cacgttgatg tgatcatcga caagtgcacc 2992981 atcacaaaca tgaaggaagc gatattccgg acggacagca aaacaagcac ggtcagaatg 2993041 acaaatacac gctactctaa tgtcggtcaa aaatggattg gtgttcagca tatttacgaa 2993101 aacaacaaca ctcaatttta acaaaaaaag tccgctgatg ttattcagcg gactttttca 2993161 atctttcttg catttcttcc ttcgtataga tgatcctcat cggatttccg ccgacaaatg 2993221 ccccgtcagg cacatcctta tggacaagcg ttccggcgga cacaactgcg ccatctccta 2993281 ttttcacccc gggcagaatg gtcgtgttgg caccaatcat cacttcgtcc ccgatcagaa 2993341 ctttgccgat ccggtattcg tgaatcaaat actcatgggc cagaatggtc gtattgtacc 2993401 cgatgattgt atttgttccg actgagatct tttccggaaa catgatatct ggcatcacca 2993461 tgagggcaaa ggatgtctgt tttccaacct tcatccgcag aaatgtgcgg tacagccagt 2993521 ttttcatccc tataaacggc gtatatctcg caatttgaat gacaatgaaa tttttgacga 2993581 cctttaaaaa aggtaccgtt tgatagacat gccacagtga gttggccccc gagaccggat 2993641 gacgatctgt ttttctcaca gattacttca ctccaacgat ttgtaataga tcactcattt 2993701 tctcaagcat aaaatccggc tcatgcttcg ccagcatttc cggcccttta atcgtccatg 2993761 cgactcctgc cgtttttgta ccggcgtttt tccctgccag cacatcatgg taattatcac 2993821 cgaccataat ggcttccgcc ggctcgcttc ctagctgttt cagcgctaac agcacaggct 2993881 cgggatcagg ctttgcattc gtcacatcat caagggtgac aactgtttca aagaattcgc 2993941 cgattcccgt gagcttgagg cccatattga cagtatctct taattttgtt gtcacaattc 2994001 ctaatgtaaa gccggctttt tttaatgcat ccagggtctc atataccgtt tcatattcag 2994061 tgacgagtga atcatgcatg tcatgattgt acgctctgta catagcgatc atatcctcgc 2994121 atttatcagg gtccatcgaa gagaacgtat caaaaagaga cggcccgata aatgcaagga 2994181 catcttctcg tttatacttg ctcggataat aatgctccag tgtatgcaaa aaggacgcga 2994241 taattaattc attcgtatta ataagcgttc cgtctaaatc aaacagaatc gtcgttactt 2994301 gtttgtcact catattgctt cctttccaac cgctgagggt ttccattttt tccacgtgtg 2994361 cgcaatagcc attgtcagca gaactgctgt ggtgacacga atcaaaagaa gcggccagac 2994421 cggtatgcca agcggaataa agacaagtgt atcttccacg accgcgtggc aggcaacgag 2994481 aaatataaat gccaatgtca tgtcccgctt gctcacgccg tcatcctcga cagctttgat 2994541 catgacaccc gctccgtagg ccagaccaat cgtcagtccc gtcaccatcg tcatagacgt 2994601 atttttattc atgccaagca gctgcgtaaa cggcgacagc cacctggaaa accgataaag 2994661 ccagcctaaa tctcttaaaa actggatgat aatcatcagc gggatcacta ttgccgccag 2994721 ctgcaaaaca ccaagtccgg ctttcgttaa tgcttctgcc aacattccta gccagctgtc 2994781 tggcgccgcg ctcttcgcag cgataaaacc gtactgcgcc gtttcctttc cgccatgcca 2994841 aatgaggttg atgacgatgg ctgacacagc ggccaaaccg atgcgcacgg ccaatatgac 2994901 gccaattctg ataccaacct ttgcggcaac tgtcgattcg ataatcaagt tatgacagaa 2994961 agaaagcata acagctaaaa taaagacttc tttcacagat aaatccaatg ttaaaatccc 2995021 ggcaattccc gcatacagat tcagcatatt tcccagtaca agcggaatgg ccgcttcacc 2995081 agaaagcccg aagagaccca ttaccggtgt gatcagccgt acaagccaat ccatgacagg 2995141 ggtatgctgg agcaaagtga ccaatagcgt taccgggaaa atcactttac ccagcgtcca 2995201 tgttgtttga aaacctgctg caagaccggc cagaaagatc ttcttcatcc ctcatccccc 2995261 tttgttgacg tctactccgc gtaccgctcc ttcgagtatc ccttgacgcg tctgaagatg 2995321 atggctgcca cagccaaaac aatcaatacg attgaaatca cctgagcgat gcgaagtgaa 2995381 tcagtcagca ttaagctgtc agtccgcatt ccttcaataa agtatcttcc gattgaatac 2995441 caaatgatat agatcaagaa catctcgcct ctacgcaaat tcgctctgcg cagcagcagt 2995501 aaaacaatga cgccgacaaa gctccatagt gattcatata aaaaagtagg atgataatat 2995561 tgcccattga tatacatttg attgatgata aattcaggca ggtgcaggtt ttctaaaaag 2995621 gctctgctga cagcctcgcc gtgcgcttcc tgattcatga agttccccca gcggccgatc 2995681 gcctggccga gcaaaatgct gggcgcggca atatccgcaa gcttccagaa cgaaaggttt 2995741 ttcactctcg aaaacacata acccgttaaa atggcgccga ttaatccgcc atgaatggca 2995801 atgccgccct tccaaatctt aatgatttct cccggatgtg ccgcataata gtcccattca 2995861 aaggcaacat aataaattcg tgcgcaaata atcgcaattg gaatggcaaa caggacaaga 2995921 tcaataaacg tatctttctg cagcccccgt ttttcacttt ccctcatcgc tatccacagc 2995981 ccgagcaaag cgccgagacc gataatgatt ccgtaccagt ggacggctaa cggccccagc 2996041 tgaaatgcta tcggattgag tggttctatc gcttcattca tttaacgcca actcctattc 2996101 ttcttgttca ccgtcttcaa tgacgtccgc cagcttgttg gtaaattgtt cagcggcatt 2996161 cagccccatc cgcttcaatc tgaagttcat tgctgccact tcgatgatga ctgcaagatt 2996221 tcggcctggg cggacgggaa tcgtcagttt tgtaatttct gtatcaatga ttttcatggt 2996281 ctcttcctca agtccgagcc ggtcgtattg cttgccctgc tcccagagtt caagattcat 2996341 gacaatcgtg attcgtttat tgcttctgac cgcgccagcg ccaaatagcg tcatcacatt 2996401 gataatgcca aggcccctga tctcaagaag gtgctcaatt aattccggag cgtttcccac 2996461 aagagtatcc tgatcctcct gccgtatttc aacgcaatca tcggcaacaa ggcgatgccc 2996521 tcttttcaca agctctagcg ctgtttcgct ttttccgacg ccgctttttc ctgtgatcag 2996581 cacgccgaca ccatatatat cgacaagaac gccatgaatt gctgtggtag gcgccagcct 2996641 gctctcaagg aagttggtta aacggcttga cagtcttgtc gttttcagcg gcgatctgag 2996701 gacaggcacc ccatttttct cggaggcgtc aatcagctcc tgcgggatgg gcatatctct 2996761 agaaagaata atagctggtg ttacatcagt gcacagagaa tccattcgct gctttttctc 2996821 ctcttcagga agctgttcaa agaaagaaag ctctgttttt ccgagaagct gcacgcgctc 2996881 cctcgggtaa tatgtaaaat atccggcaat ttcaatacct ggtcttgata ggtcactcat 2996941 tgtaatcggg cggttaattc cttcttctcc gctgattaat tccaaattga actgttccat 2997001 tacgtctttt gtgcgaacct ttgccacgat atgttcctcc tgttccgggc tgccccgagc 2997061 ttgctcacaa tactttcatt ttatcacttt cgggcttgaa cctaaaacag attttataaa 2997121 aggggggaaa acacctcagc tggtctagat cactagtctg aaaaagagta aaataaaggt 2997181 attcaaattc cagaaaggcg gatcatctat ggcagagagt cttcttatca aagacattgc 2997241 gatcgtgaca gaaaatgaag taatcaaaaa cggctatgtc ggaatcaatg acggaaaaat 2997301 cagcacagtt tcaacagaac ggcccaagga gccatattca aaagagattc aagcacctgc 2997361 ggattccgtt ttgcttcccg gcatgattga cattcatatc cacggcggct atggcgcaga 2997421 tacaatggat gctagctttt ccacgctcga catcatgtcg tcaagactgc ccgaagaagg 2997481 cacgacgagc tttttagcca caacgattac ccaagagcat gggaacattt ctcaagcttt 2997541 ggtgaacgca agagagtgga aagcggctga agagtcctct ttattaggtg cagaactgct 2997601 cggcattcat ttagagggcc cctttgtttc gcctaaaaga gccggagcgc agccaaagga 2997661 gtggattagg ccttcggatg ttgagctttt caaaaagtgg cagcaggagg cgggcggact 2997721 gatcaaaatt gttacacttg cgccggagga ggatcagcat tttgaactga tccgccattt 2997781 gaaagacgaa tcgattatcg catccatggg gcacacggat gccgattccg cattgctgtc 2997841 ggatgccgca aaagcagggg cgagccatat gactcatctg tacaacgcga tgagcccgtt 2997901 tcatcaccga gagcccggag tgatcggaac ggcgctggcc catgatgggt ttgtgacaga 2997961 gcttatcgcc gatggcattc actcccatcc tttagctgca aagcttgctt ttttggcgaa 2998021 aggcagcagc aagctcattt taattaccga ttccatgagg gcaaaaggac tgaaagacgg 2998081 cgtatatgag ttcggcggcc aaagtgtgac ggtaagagga cgaacagcac ttctttcaga 2998141 cggaaccctt gccggttcga tcctcaaaat gaacgaaggc gcacggcata tgcgtgagtt 2998201 tacaaattgc tcttggacgg atatagctaa tataacttct gaaaacgcgg ccaaacagct 2998261 gggcatcttt gaccgaaaag gcagtgtgac tgtgggaaaa gatgcagatt tggtgattgt 2998321 cagcagtgat tgcgaggtga ttctcaccat ttgccgcgga aacattgcat ttatatccaa 2998381 ggaggctgac cagatatgaa agtaatggaa tgtcaaacgt atgaagagct aagccaaata 2998441 gcagccagaa taacggcaga tacaatcaaa gaaaaacctg atgctgttct cggtttagcg 2998501 acgggcggca caccggaagg cacgtatcgc cagctgatcc gcctgcacca aactgagaat 2998561 ctctcatttc aaaacatcac tacagttaat ttggatgagt acgccggact ttcaagcgat 2998621 gacccgaaca gctatcactt ctatatgaac gaccgttttt ttcagcatat cgacagcaag 2998681 cctagccggc attttattcc gaatggaaat gcagacgatt tggaggccga atgcagacgg 2998741 tatgaacagc tagtcgattc cctcggcgac actgacattc agcttctcgg catcggccga 2998801 aacggacaca tcggctttaa cgaaccggga acgtctttca agtcgcgaac tcatgttgtg 2998861 acattaaatg agcaaacccg ccaagcgaat gccagatatt ttccctccat agacagcgtg 2998921 ccgaaaaaag cactgacaat gggaattcaa acgatactct caagcaagcg cattctgctg 2998981 cttatttctg gaaaaagcaa agcggaagct gttcgtaagc tgttagaagg aaacataagc 2999041 gaagattttc ccgcatctgc tttgcacctg cattccgatg ttacggtttt gattgatcgt 2999101 gaagccgcgt cattaagacc ttgaaaggaa catgctgact tatgaatatc aataaacaat 2999161 cgcctattcc gatttactat cagattatgg agcaattaaa aacccaaatt aagaacggag 2999221 agctgcagcc ggatatgcct cttccttctg agcgcgaata tgccgaacaa ttcgggatca 2999281 gccggatgac agttcgccag gcgctttcta atttagttaa tgaaggcttg ctctatcgcc 2999341 tgaaagggcg gggcaccttt gtcagcaagc caaaaatgga acaagcactt caagggctga 2999401 caagctttac cgaggatatg aaaagccgcg ggatgacacc gggcagcagg ctcattgatt 2999461 atcagcttat tgattcaact gaggagctcg cggctatatt aggctgcggg cacccctcct 2999521 ctatccataa aatcactcgg gtgcggctgg caaatgatat tccgatggcg attgagtcct 2999581 cacatattcc gtttgagctt gcgggtgaat tgaacgaatc gcattttcag tcgtcgatct 2999641 atgatcatat tgaaaggtac aacagcatac cgatttcccg tgcaaaacag gagcttgagc 2999701 caagcgctgc caccacggaa gaagcgaata ttcttggtat tcaaaaggga gcgcctgtcc 2999761 tattaattaa acgaacaaca tatctgcaga acggaactgc ttttgagcat gcaaaatccg 2999821 tatacagagg cgaccgttat acatttgtcc actatatgga tcgtctttca taaaaaaagc 2999881 ctccaaccct ttttaaggat tggagacatg gcgaaaatca aactggtctg gtgccggacg 2999941 atatgtttct tttttcgtct tgaacttcca gatcggtgat ttcgttttgc cgttaaaact 3000001 gtcttccact ataatgtacc aataataaac agactgcggt tcaagatgat cccagcggaa 3000061 ttcagctgtg tccccgctct tcacttgctc ccgttttccg agctcttcat tggtatatac 3000121 gttacattca aaataatcgg tttccacctt tttgattctt ggcttcaaat caagcgaaag 3000181 ggaaaattca tccttgttgc cataggtatc cgtatcatag tagttcttat cctttacata 3000241 cggagagtac gtcgatacgt gcaccatgtc attggcttgg tcaaattgaa gcaaacgcaa 3000301 atacccttgg ccgccttctg gcccgccctg ataatcggcc agcatttgat gcacaagacg 3000361 atccggtttc ccatcaccat catcatccag ctcatctgtt tttctcatcg cactatgata 3000421 atgcccgctc aacaccatca cgacattcgg gttcggcttt acgatttctt tgaatatttt 3000481 ctctccgatt gggcttctgt ttccgctgac cagcaaatac tcatgaaaag ctaaaatggc 3000541 catccggtca ggatgcttct tcagcacctg attcatccac gcgatgtctt catccgtaat 3000601 gccccatccc atgtacagca tgatataatc attgccgttg ctagaaatca ggtcataatg 3000661 tccgcggtta tttttatagg aaccgccata atgaaatttt ttatcaaaac gatcgctgcc 3000721 aaaatatttg ccaaacgccc tgtaggagcc gtccttatgt ccgacatcgt gattgccggc 3000781 cagcacgccg taaggaattc cgctcttatc cagaacggac attgaccgat cagcgttttt 3000841 ccactgtctg atatcggcgg aatcatctac aatatcaccc gtgtggaaca catatttgat 3000901 attgagctgc ttttgattat cttttatcca ttcggtctgt ttatcaaaaa tatgcggata 3000961 gctttcggcg taatactgtg tatcagacat ccagacaaat gtgtacatat ccttcgcagg 3001021 aggaatttca tcctgtacaa tcacattcat tttcgactcc cgtacaaaat cggcggcaat 3001081 cacagacgct ttcagcgtaa acggtttgtc atccttcgcg acgaagctgt caacaggctg 3001141 ccattcgttt gtccgataat tccaagcata catcgtcacc tttctccccg gcaaagaact 3001201 gcccttccag actgattctg ccagatcatt ctcatcaatt gatggatcaa ccgtcacttc 3001261 aaagcgatga taagggaaaa gctctttgtt ttctgtcgat actgtttttc catcagcagc 3001321 tgatacccgc tccaattctt tattcgtaaa tggggtctcc ctttccggca caaagctttt 3001381 cggcggttca gtcagtgacg cgtgcttaaa tattttcaca tgattgcgcg ctgtatattg 3001441 aaatccccta taaaaaccaa catccatggc atcattcgtc ggatctttca cccgtacaga 3001501 aagcttggcc ttatgcgtgt cggcttcgct gtctataacc tccggctggt ccggatgctc 3001561 tcgttcggtt ttaaatatcc tctcaatcac tgttttattg cccgcgagat ccgttgctgt 3001621 cacttttaga gaatgttttc ccggcaaaag gtcagaagat gacgtatgat atgggagtgt 3001681 aatgctttct ccatctaacg acgcctccgc ttcctcaatt ctgctccatt tatcatacat 3001741 atccgcctgc aggataaggt ttcctttata cgtttgcccc tcggtgatat tcggctcaat 3001801 gtgaggtcct gaattatcta cccgtacaac caggctgaca ttttccttcc cgtcgcttgc 3001861 ttgaatatgg tgagcgcctt cagaaagctt tgatgtatcc cactccagca gctgtgatgt 3001921 aaatagtccg tcaggcagat tgaactgaaa ttgccagctt ttattcgagc gctgattatc 3001981 gccaataaag agttccttct caggagacac cctctgatct ctgatcaccg ttccatccga 3002041 taacaccaat cgggcgtttt tgactaagaa gtcatcacgg ttttcagccg tatcaaacgg 3002101 agacaccttc gaacctgaac gtatcgtaat acgctgcagc tgcttccctt tccgaagcag 3002161 tgtctctggc aatggaacag aataggtgcg gtatttattt gttgtatcat cgaacacctt 3002221 cagcactttg ccttccatcg ttaccgcgtt tttaaaataa aggttcgttt tcctcgtatc 3002281 gaatgcaaaa tatacttctt tttccatcgc gggctctgtc acttgttttt tcccgtcaat 3002341 ccatagctta atgctgtcag ctcgcccttc tgtcgtggct ttgagaaatt gagttcccga 3002401 cagcgtgtct ctgttttcaa tattcatccg cagaccgtgc gccttgcttg tttgtttaat 3002461 atcaatcatt ttgaccggcg ttctcgcttc attgatcccg tccccggccg ccacataata 3002521 ctctagctga tccttcccga tcaattcagg cgaatacaca atataatgga agagattatc 3002581 gttgcggtct ttttcagcaa gaattcgctt aaacggtttg ttctcatccg tccggtagta 3002641 aaaggccact gttttcacta ggcttcggtc ccgtatgtca gcccgcagct caatgctttc 3002701 agcagggcgg acaggcttgc ggtcagtcaa atcctcaatg accggctttt ctttatcgag 3002761 cttgattttc cgtttctggt cgggcacctg tgcctgtaat acggttccgg gagacggatt 3002821 cttttccccg attgaaatgt tcagaagttc tgctgttccg ttcagtggat acttataaag 3002881 cactgatgac agccggcgca gcgcatgttt ccgataatgc gcaaccgaaa tgtcctttcc 3002941 tgtattcgtt gatatcacaa cggcccgcgg cctcgtattg gccataccct ctgtctcgtc 3003001 tatcaccgca agattttttc cttcttttag ttgtgtctga taataacgat tgaaatccgc 3003061 tgacgtcaat tctggatgcc cggcaggctt cagccagacg acaaacgttt cgccggatgg 3003121 tatcaagatc ctttcatcag gtctccaaat cagatcggag tcaggccctt cttttgggta 3003181 gcggtaacgg atatggtagt ctttaaaatc aatcgttctg tcagtcgtat taaaaatctc 3003241 aataaattca taaccgtctg cgcgtcctat attcttcgta tcaaccgcca gctctgtgat 3003301 cagaagctcc ggaatatggg caaggtcagc ctggtatcct tcaagcttca gtttcttcgt 3003361 ctccgactca acccgctgct tcccattcga catcacaatg taatactcaa gctcgctgtt 3003421 ccaaatcaaa cgtttcggaa tttgtgccaa aaacttgcgg accgctccgg gggtcgggtc 3003481 catcggcacc attttgtagc ccagctcatt actttgttta taaaaaagaa aggcggaaaa 3003541 tgcttgatac gaattatcgc gaacttgagc ctcaatcatt agattgcttc tcatttcagc 3003601 tttcacatca atttgaggag gattttcaag caagggtatg taatgaggcg tttgaaatag 3003661 ttcctgctgt acaacaggaa aagctttcga ttcatgatgg ccgccagaca aaacggaaag 3003721 aaaagacagt aatatagaag caataaccgt gtatttcctc atcaaagcac ctcccttttc 3003781 atgtattttg cgtctgaaca gggaagctta tgagttcatt tttgtgcata aagaacaaaa 3003841 aaacgtctgt ctcttgaaaa ttccactatt acccagtaaa ctaaggatag ttaaccagtt 3003901 aacaattaaa tcagagaggc aaattgatgg acaacagcat tcatgatgaa ttatttcaag 3003961 ctatacaaca attcgcatta aaaagggata aacgcgtctg gcaaaaggtg cagataccat 3004021 ccattggcat atcctcacaa catcacgatc acctcaaaaa agactggact ttgacccagc 3004081 ttcacattgt ttcctgcata cataccagcc aaaatgtgaa caacagcttc ttagcatccc 3004141 gtttacacat ctcaaaagcc gctgtttcaa aagcggttca tgctttgttg aaacacaata 3004201 tcattacagt gacaaaaaag cctggcaaca aaaaagaaat tttttatacg ctaactgata 3004261 gcggcagaaa attggcggca ttacatgaac agcttcatga gaaagcaaag gagcaatata 3004321 aacagctttt caatgaattt tcaattgatg atttaaaaac agtgactgcg tttttcaact 3004381 tgtggatcaa atatatgtaa aaagagtctc acccgcatgg gagagacctt tggaattcta 3004441 ttatgccccg tcaaacgcaa cgagaagtga aacaggtccg cgtgtataca gaccggactc 3004501 agcataacaa aaatcttcct ctaatctgat attccgcatc ttatccagca caatattagc 3004561 tacaatttcg atttcgtttt tggcaaaagc tgctcctaca cagttatgaa tgccggatcc 3004621 gaaagcgaga tgccgggcgg cgccgctaaa agcgctcttg ataccaagat cttcccgatg 3004681 aatattaaac acgtcaggct gttcaaatgc ttcagggtcc cggttagccg caccgatcat 3004741 acaaaaaaca atcgtatctt ttttgatttc cataccgccg accactgtat cttgggacag 3004801 ctgccgcgga atcagctgaa ccggcggttt ataacgcaat gtctccgcaa tggctctcgg 3004861 aactaacgaa cggtcagcca aaacatcatt catctgctca ggattgttga gcaaatggta 3004921 gatcatcagt gccagcgtct tatcagccgg ttccgttgcg gctaacagca cattaagaat 3004981 cagtgcgagt atatccttgt ccgacagcgc catgccttca tattcagaag tacataggat 3005041 cgaaattaaa tctgatcccg gattgacgcg acgttcttta atgaccggca tcaagtattg 3005101 ggaaagctgt tcgctgcacc ataacgaatg tgcccgcgct tcaggagatt gagagatact 3005161 cgtgataaaa tcggcaactc cgctgtgcca ctcagagatt ttttcatggt ctcttttatc 3005221 cagcccgagc atgtccatcg tgacgcacac cgcaaacgtc tttccaaaat cattgacgag 3005281 atcacttttc cctctttcaa gataaggcgc taacaagttt tctgcatttt gtttaatcaa 3005341 tggagacaga tgatccagtg cgtcaccgat aaagcttctc actacaattc ttcttttggc 3005401 agagtgttct tttccatgca tttgggccag cacagggcct cgcatgactg gttcggcacg 3005461 ctcaacaagt gatttcgtcg tgaagatatc cggatgctga aggatatagc ggacatcatg 3005521 atagcggctg ataaaataac tgtctatcga ctcttcataa tgaaccggat cttcctcccg 3005581 cagttgtgaa aaataagcat atggattgtt ttgaaattga tcagaaagca cactaaacaa 3005641 tttaatcgat tggctcatgt tttactcccc ctatcatcct tcagatgtga tccgtttctc 3005701 agaaagcatc tgcgccattt cctgtacaat gagataccct tgattcggcc gcatacaaat 3005761 agaaaattca tggttactga tcttctcacc cagcttccac ggacgatgat aagcaaggag 3005821 tgtctcttcc acctctaaaa tatccggagc tccgataaaa aacggcagct cagctatgac 3005881 atattccaca gccaaattca gcatatcctc actgacttct tccatcatca aactgacgcc 3005941 ccgcgcacgc ccgattatcg cttcacgaga catgtccaaa caagcatgtc gaaaatgagg 3006001 ctgctcaaaa aatgcatgtt caacttcttg tctcaacagc tggtaggctt tgttatctat 3006061 aaaatcagaa aatgtatgaa tcgccttcgg atccccgcca tgagccacaa gggctctttc 3006121 tgcaaatctc ctgtttcgtg atacctcttt ccttactttt cgttcagcct ttcctctcgg 3006181 agttccaagc gcttctagaa gattagccgc ctcatgccct gcaagtaaaa ctgaaacgct 3006241 tttaaattga gctttcgccc atccaattaa tctgtaaata taatcctctg aaaacctgct 3006301 gttaaatggg ctgatcccca ccaaaacatg cctgcgccgt tcaaatattt ctctgcagtt 3006361 ttctgttaat gcctcagcaa taaaatgcac agaccttctt tccgttacca ttccggtcat 3006421 ctcattcacc cctaaaactt atcccgcttt aagtcatcac cctcaaatac aagatggaat 3006481 agctagaaca actgaacaag acgaatggca ggcatcactt aaagtttcca aatgtttttt 3006541 aagattttaa taatcatttt caatacccat atcatgataa atgtttacta gtaaacatta 3006601 gtcattttat cccttttcct tccaaacgtc aatatgatct gtgcccaaat atttgaaaat 3006661 aaatgtaaac atcacatttt ccacacactt tttacacgca tattcagcat gacatatcaa 3006721 caaatagtct aaacaccaac aattgacaac gaaaacaaga aaagataaaa taaaattgtt 3006781 caccagtaaa cgatttgttt tattgtttca tcgtaaacta ttattcctaa gaaagaaggt 3006841 agcctatgtc tgatttgaca aaacagatga tatacgacat atacgtgaga ctgctgcacc 3006901 ttaatgaaca aaaagcgaac acttcacttc agcaattttt taaggaggcc gcagaagagg 3006961 atgtagctga aattcccaaa aatatgacaa gcattcacgt cattgactgc atcggccagc 3007021 atgaacccat taataatgcc ggaattgcca gaaaaatgaa cttatcgaaa gcgaatgtaa 3007081 cgaaaatcag cacaaaactg atcaaggaag aattcattaa cagctatcag ctgacagata 3007141 acaaaaaaga agtttatttt aaattaaccc gtaaaggcag acggattttc gacttacatg 3007201 agaaactgca taaaaaaaag gagctggctt tttaccaatt cctcgattca ttttcacaag 3007261 aagaacaaaa ggctgtattg aagtttctag agcagttgac gtcaacactt gaagcagaac 3007321 aaaccgatgg gactccagac aaacctgtaa agtaaacaaa aaggcggtgt acactttggc 3007381 tcatacaaaa tcaaaggcag tattgatctt atacactgtt tgcttcagtg cattttttgc 3007441 atctttaagc cagaacattt attcacctat tcttccgatc attaaagaat cattccatgt 3007501 ttccacagct atggtgaacc tgtcagtctc agtttttatg attgtgacag caataatgca 3007561 aattatatta ggagcgatca ttgattttaa aggcgctcgg atcgtcttga ttaccggtat 3007621 tctggcaacg gcagcagcca gcatcggctg tgcggtgact actgacttta ccttgtttct 3007681 gatattcaga atgatacagg cagccggttc cgcagcactg cctcttattg ctgccacaac 3007741 gatcggacag ctgtttacag gaaatgaacg cgggagtgca atgggaacgt atcaaatgct 3007801 cctgtctgtc gcaccggcta ttgctccagt tctaggagga ttcataggcg gagcagccgg 3007861 atacgaaggg attttttgga tacttgcggc catctctatc gttttgctgg tgacaaacag 3007921 catcaccttt cctaaagatt ctccaactga atctatgcag caagccaaag gcaatgtgtt 3007981 cgctcattat aaatcaatat ttacaaatcg aacagggaac gtcattttga ctttaagttt 3008041 tgttctcttt ttcatttatt ttgcagtaat tgtctacctc ccaatattgc tgacagagca 3008101 ttaccatata gatgtgggta tagcaggact gttatatttg ccgctggcgc tgagcacgat 3008161 tgcaggtacg tttctgttta aaagaataca ggcaaaaatc gggctgcaca ccttgtttat 3008221 cggaagcaat gtgattgccg cctgcagcat cattttattt gctgttacac attccgtttc 3008281 tctcgttctc atggctctga cgctggcact gtttggcatc tcgatggggg ttattcctcc 3008341 cttgtactct acaatgatta ctaatgaatt tgagcacaac agagggagtg caatcggaat 3008401 gtttaacttt atccgatata caggcatggc agcaggtccg atggtatctg cctacttgct 3008461 cacaatgatg ccgtctgcca tgtcctttag cctcctaggc cttggatttg ccgcattgag 3008521 cttttgcctt cttccgccaa tgttttcgcc gcagaagcgc acgaaacaaa aaaagcacca 3008581 catgtaaaaa agctgccttt gcgggcagct ttttttattt ttttctaagc ggctctaaaa 3008641 tgcctttttg aatcagcaaa tggaagaccg acaggataac ggatgcccat atcgctgtgc 3008701 cgaagccgtc gatttgaaag ctgtcaccca taatggacgc ggtcatcata agcgtgatgg 3008761 cgttaatcac aaacaagaag agtccaagcg tcaccatggt gaccggcagt gtaaatataa 3008821 ttaaaagcgg tttaatcagc acgtttaaga tcgataaaat gaggctggcg ataatcgctg 3008881 ccccaatgct gctgatatgg atggagtcaa tatatccatc aatgacgatt aataacaatg 3008941 cattgactaa aatgctgact gcccatttta ccatgtcatt tcatatccct ttctgacggg 3009001 acgataaaaa tccaaatgat ataaatgagc aaaaccggca agacacttgt cataatggct 3009061 aagatgacag ttatgactct gaggagtgat gcgtcccaat tgaaatattc cgcgagacct 3009121 ccgataacac cggcgatttt cttatttttt tctgagcgat aaagcttatt cattcgatca 3009181 cctctgtgag tactttagtt tgatggcgcc tgttagtgat tctgagaaga cggtgatgtt 3009241 ttgatcatgt gcctgatttg aagtgaacat catttctttt tgaatcgtat catttttttc 3009301 cttcagcatc tctacatcca ttaattcatg ggacagcgta ccaagattgc ttttcagctc 3009361 tgccttcact gcgagatcgt ccggaattgc aagctctaca tttccagtcg ttgtttttgc 3009421 ataaatggag cggcagtctg attctgttac gttaatcgca atatttccgt taaagctttg 3009481 aacgtcaatg gattcgcttt tccctcggag atcgatcaat ccgttaatgg tttccgcttc 3009541 tatcgtaccg cagctgtggc ttgcgagctt aatttgcccg ttggccgttt cagctatggc 3009601 tttttcggct gttaaatacg agaacgacag cacgccgttt gtcgttttcg ctgagaactc 3009661 ttttacatgt aaatgttccc ctctgactgg accgttaaac agcttcaccc gaatcttatc 3009721 atactccttc tgaggaatat acaaagtgac attcgttttc atcgtctttt tctcagtacg 3009781 gataaaaaac ttattacctt tgatttcaca ttcaatatgc tgaagaaatg cgtgtctcgc 3009841 cgcatcctgg ctgtcagcgc gatatacctt cgcctggcat tccgctctga tatcgtcatc 3009901 ttcccaaggg acgatattta cgctgccatt ggcaatttgc agctcaacac tggaaaagtc 3009961 agtatcttta aattgaaaaa tgtgctgaac atcatacgca tggccaaagt ttaaatcaag 3010021 gtcaacttcc ttgacctttt tcacagcaga atcaatccag tcaaacagct tggctcctaa 3010081 agacggtttg ccgctttctt tttttgccgt tgtaaatggc tcttcctcgt catgaacgtg 3010141 aactgagagc gctgtgattt tctcttcttt ttccttgtag tcgctgtcaa gcttttcaat 3010201 cagtgtcaaa gcttcttgtg ctgtaagctt tccttcctca acaagcttaa ggattcgttc 3010261 cttttcttgc ttcattacga tctcctcccc attgtctact tatgctgcac gcaggacctt 3010321 aatgccctga atcacattcc aaatgataat gccaatgaca actaagaaat aaataaccgc 3010381 tcccccgatg attacaaata caggaagcaa gctgtctcca tcaatcgcaa cggctccgcc 3010441 aagtaaagca ataaaaagga acagccagcc gacaaacgga acaatgtgag aaataagaga 3010501 gcgtatcgca tggcgttttg tttctttctc atttacaaca aaatatgcga caatcggcac 3010561 aatgattggc gcaatgaaca cactgaaata acaaagtgat gcaataatag cttgattacg 3010621 gttcaattca ttccacactc ctattgtgaa ttgtccatga caaaagatca gggacgtttt 3010681 acttatttat acgtttaaaa tctcttcagg tttcaaattc attctttaga catgctccga 3010741 tttacggaaa ttggatttta aaaagtttta gaagtagaat cttccggcta taccgattac 3010801 aatatgtaaa aagcttacgg caaccaagga ggctggacaa gcaatggaga aagatcccag 3010861 tgactataca gtaacacaag aatcagtgtt aaagctgatt caggaacaaa aaagaatgaa 3010921 tcgtgaaatg atcaccgagc ttgagcagat tcacggaccc ttcccgatct ctcacgatat 3010981 ccaatatata aaagtgctgc tcgacagcag caacacacat attgttcaag atttaatgag 3011041 tgtaagtaag cagctgtata agaagacttt gtaattgcgg aaaacatatc attcattata 3011101 actgaaacaa agctaaaggt tagatgacaa tatcttgcct tttttgtttt gaaaaaacaa 3011161 gtgattccct ggctgtcaca aaatgattgt aacaaaaaaa gcctgccggc acatccagtt 3011221 aatggactct gtcggcaagc tgtaactatc agaaagagat agccgttcaa aattaacgta 3011281 acaattgaag cacgttttgc ggctgttggt ttgcttgagc aagcatcgct tgagaagctt 3011341 gagaaggaat gttgttcttt gtgaactcgc tcatttcttt cgccatgtca acgtcacgga 3011401 tacgggactc agcagctgtc aggttttcag aagaagcacc aaggttgttg attgtgtgct 3011461 ctagacggtt ttgtaccgca ccaagtttag cacgttggtt tgagacattg ttgattgcag 3011521 tatcaatact ttcaagttgt gtatcaaaag gagtattagc aaaatctgtt acattaagtg 3011581 cgtttactcc taaagcagtt gatgacatgc tgtcaatgtt aactgtaagc tgctggccag 3011641 catttgctcc aatttggaaa gtgaaaccat cagtttcagt accatctaat aactttttgc 3011701 cgttgaattc agtacgattt gaaatgccat caacttcctc aataagcgca tccatttcat 3011761 ctttaattgc accaagatct tctgcttgtt gtgtacctgt gtttcctgct tgaacagtaa 3011821 gttcacttct aaacctatta tgccgtaaag aaaaagcttg cctgctaagc ccaaggatgg 3011881 acttgccgac aagctgtccc ctcttaacag agggttttaa gatgtagctg tttcttttgc 3011941 tttcaagagc gatttcatgc gtgttttgtc acgttcgata acaggcttta aataacggcc 3012001 tgtatacgat tcttcaactt cagtgatttc ctcaggcgtt ccagacgcga caatggttcc 3012061 gcctccggct ccgccttccg ggcccaaatc cacaatgtaa tcggccgtct taatgatatc 3012121 aagattgtgc tcaataacca gtacagtgtc tccgttgtct accaaccgtt gcagcacgac 3012181 aagaagcctg gcgatatcgt cgacatgcaa acctgtcgtc ggctcatcta aaatgtagag 3012241 cgtacgtccg gttgagcgtt tgtgcagctc tgacgcgagc ttcacgcgct gcgcttctcc 3012301 gcctgacaag gtcgtcgccg gctggccgag cgtaatataa cctaaaccaa catcataaag 3012361 ggtttggagc ttgcgtttga ttttcgggat attttcaaag aaagaaagag catcttcaac 3012421 cgtcatatca agcacatcag agatgctttt tcctttgtac gtcacttcaa gcgtttcacg 3012481 gttatagcgt ttgccgtgac acacctcgca tggaacgtat acgtcaggaa ggaagtgcat 3012541 ttcaatttta ataatcccgt ctccgcggca ggcttcacat cgtccgccct tcacgttgaa 3012601 gctgaaacgg ccttttttat agccgcggac cttcgcttca tttgtctgcg cgaatacatc 3012661 acgaatgtca tcaaatacac cggtgtatgt cgcagggttg gatctcggcg ttcttccgat 3012721 tggcgcctgg tcaatgtcaa tgactttatc taaatgatcc aaacctttaa tctctttatg 3012781 gctgccgggc ttcgctttcg ctttatgaag cttttgcgcc agcgccttat gcaaaatttc 3012841 attaacgagt gtactctttc ctgaaccgga aacacctgta actgctgtaa acgtcccaag 3012901 cgggaacttg gcattcactt ttttcaggtt gttttctgat gcacctttaa tttcaatgta 3012961 acgtccgtcc ggctttcttc tttcaggagg caatgggata aactttttcc ctgataaata 3013021 gctgcccgtt aatgaatttg gatcttccat cacttcttcc ggcgtacccg cagatatcac 3013081 ctgtccgccg tgaatgccgg ctcccggtcc aatatctatt aaataatctg ctgccatcat 3013141 cgtgtcctca tcatgttcga caacaatcag cgtgttcccg aggtctctca tatttttcag 3013201 agcgctgatc aagcggtcgt tatcacgctg atgcagaccg atagacggct catctaaaat 3013261 ataaagcaca ccggataaac gcgagccaat ttgagtcgcc agcctgatgc gctgcgcctc 3013321 tcctccggac aatgtacccg ctgccctgct caatgtcagg taatcgaggc cgactttgtc 3013381 cagaaagctt aagcgctcca caatttcgcg caaaatcaaa ttggcgatct gcatatcctt 3013441 ctcagaaagg gtaagatctt taaagaaggc aagtgcgtcg gcgacagaca gctcggtaat 3013501 tttcccaatg tggcggccgt caatcagtac ggcaagcgcc tctttcttta accgatagcc 3013561 tttgcacgtc ggacaagact tctgagacat atactgctcc atttgctcac gtatgaaatc 3013621 ggagcctgtc tccttatagc gtctttcaat gttgcgcaat acgccttcaa attgaatttc 3013681 accttcgcgg atttgtccaa aatcattttc atatcggaaa taaatcaggt catccccgct 3013741 gccgtacagc actttatcca gttgatgctt cggcaaatct ttgaccggca catccatatc 3013801 aatcccgtag tgggtgcaga ctgcctcaag cagctgagga taatattgtg agctgatcgg 3013861 tgtccaaggg gcgaccgcat tctccttcaa tgacaaatct tgattgggga tgacaagatc 3013921 ggcatccact tcaagcttca ttccgagacc gtcacacgtc ggacacgccc cgaacggact 3013981 gttaaacgaa aacagacgcg gctcaagctc accaattgaa aatccgcagt gcggacaggc 3014041 atgatgctcg ctgaacatca gctcttcctc accgatgaca tcgatcataa cccgtccttc 3014101 acctaaacga agcgccgttt ccaatgaatc tgacagccgg gctgccacgc cttctttcac 3014161 gacaatccgg tcaatgacta cctcaatgga atgcttcttg ttcttttcta attcgatatc 3014221 gtcggaaagc tcagccatct cgccgtcaat tctgactctg acatagcctt gtttcctaat 3014281 ctgttcaagc actttgacat gagcgccttt tcggcccgag acaatcggcg ccagcacctg 3014341 aagcttcgtc cgttccgggt attccagaat tctgtccacc atttgctcga tggtctggga 3014401 tgtaatctca attccgtgtt ccggacaatg aggcttccct actctcgcat ataaaagacg 3014461 cagataatca taaatctcag ttaccgtacc gacagtagac ctcggattgc ggctcgttgt 3014521 tttctgatca atgctgatgg cgggagagag cccctcaatt gcatccacat ccggcttatc 3014581 catttgccct aaaaactggc gggcataggc agacagcgac tcgacatacc gtctctgtcc 3014641 ttcagcatat atcgtgtcaa aggcaaggga ggatttacct gatccggaca aacccgtgac 3014701 aacgacaagc tgatctctcg gaatcgttac atctatattt ttcaggttat gcgccctggc 3014761 tcccttcacc tctatccgat ccatagccat ttgttcatca tccttccgct tttagctcta 3014821 aaagtaaatc gcgaagctcc gcggctctct caaagtcaag cgccttggcg gcttccttca 3014881 tttcatgctc catctgttca acgactttct ggcgttcttt cttcgtcatt ttcgacagct 3014941 tcggcgcggc ttttgttttg tattccgctt tatcctcagc tgctactgtg gcacgaatga 3015001 catcgcgaat ttctttattt atcgttttcg gcgtaatgcc gtgctcttcg ttaaaccgct 3015061 cctgctgctc gcggcggcgt tttgtttcat taatcgcaat ttccatagac ttcgttattt 3015121 tatcggcgta cataatgacg cggccttccg catttctcgc tgcccgtccg atggtctgga 3015181 tcagcgaccg ctccgaacga aggaaacctt ccttatccgc atccaaaatc gcaacaaggg 3015241 atacttcggg aatgtccaaa ccttccctca gcaggttgat gccgacaagc acatcgtact 3015301 tgccaaggcg caggtcgcgg ataatttcaa tccgttcaag cgtcttgatc tcagaatgca 3015361 gatagtttac tttaatgccg atttccttta aataatcggt cagatcctct gacatcttct 3015421 tcgtcaaagt tgtcacaagc acccgttcat tccgctcgat tcttgcttga atttcgccga 3015481 tcaagtcgtc aatctgacct tcgattggac ggacgtcaat aagcgggtca agaagccccg 3015541 tcggacgaat gatctgttcg accatttcat ctgtatgttc aatctcgtac ggccctggtg 3015601 ttgctgatac atacacgata ttgtgcatat gcttttcaaa ttcctcaaaa cgaagcggac 3015661 ggttatcaag cgctgatgga agccggaagc cgtgatccac gagcacctgt ttccgcgcct 3015721 ggtctccgtt aaacatgccg cgcacctgag gaattgtcac atgcgactca tccaccacga 3015781 tcataaaatc gtctgggaaa taatcaagaa gcgtatacgg cgttgaacct ggaggccgca 3015841 gagtcaaatg tcttgaatag ttctcgatgc cggagcagaa acccatttca cgcatcattt 3015901 caagatcata tcttgtccgc tgctctaaac gctgcgcttc aaggagcttt ccgttttcat 3015961 gcatgacctt cagctgctcc tcaagctcct tctcgatatt ttgaatcgcc ttctccattt 3016021 tctcggcccg cgttacgaag tgggatgccg ggaaaatcgc aacatgatct cggtcgccga 3016081 gaatttctcc tgtcagcgca tctacttccc gaatccgttc gatttcgtca ccgaaaaatt 3016141 caactctgac acaatgctca tcacgggatg ccggaaagat ttccactaca tccccgcgca 3016201 cacgaaatgt accgcgctga aagtcgatat cgttgcgggc atattggatg tctacaagtt 3016261 ttctgagcag ctcgttgcgc tcaatttcca tttcagtccg cagtgacacg accatttccc 3016321 ggtattcctc aggcgaaccg aggccgtata tacaagacac actcgcaata ataatgacat 3016381 ctctgcgctc aaacaaagct gatgtggcgg agtgtctcag tttatcaatt tcatcattaa 3016441 tactagcgtc tttctctata aatgtatccg tttgaggcac atacgcctcc ggctgataat 3016501 aatcatagta gctgacaaaa tactcgacag cattgttcgg aaaaaattcc ttgaactcac 3016561 tgtaaagctg tccagcaagg gttttgttat gggcaatcac gagagtcggc ttattgactt 3016621 ctttaatcaa attggacacc gtaaatgttt tcccagttcc tgttgcaccc agcagagtct 3016681 gatgcttctt gccctcctga attcctttca caagcttttc aatggctttc ggctgatctc 3016741 cctggggctg atatttcgag actaactcaa agcgatcttt cacaaaaata agcctccgtt 3016801 tctttaacga aatcttccta tagatatagt aacacaatgg aaagcaaaat cactaaaaat 3016861 acgaactaaa gttcggtggt tttttatttc cagctgtttt tgtgtataaa aaacctgctt 3016921 ttaaaacgta aaagcaggta ttcagtcttt atattcatta tgtccgattt attcttcttt 3016981 tttctctgca gcttttttgg ccatatacag tccgccagcc acaagagaca caacatccaa 3017041 tcctacaata aaatacgttt ctgtatagcc ttttaaataa gaggcaaaca gcaatgcagc 3017101 tgttaaagcg atcgccacat aatgattaaa ggtgactcta gtaaatagaa caacaagcat 3017161 aaaagggaaa aacaatgcaa aaacggcttt tgtaatcaac aaaaaccctc ctcagggatt 3017221 cttcatctga tctgattata gtaaaaaatg aagaatcgga caatcgtgca ttcgctccct 3017281 ctacttacac catacccctt ttcagccaaa atcaatcacc atatttgcat tttggtgccg 3017341 gtcaaaactt attccatggt gccgctgttc taatcagcgg cacttttttt attacatcat 3017401 caagtccgcc gccagattcc gagaataaaa gaaaataggc atacagtacc agtacggccg 3017461 catttttcag gataatataa ccaacttaac tattcatttt atttaggact ttctgcgttt 3017521 gacagcattt tcctgaaaac ctacaattaa atgatagtgt ttactatcat tttttaaaca 3017581 caggctccgc aataaaaaga ctagagagaa aaacaaaatg aatgaagaaa agaggggttt 3017641 caaatatgta ttctgtttta tttcgccagg cagaagagtc cagccagctg gctggagcaa 3017701 aaggaatgaa tttgattaaa ttgaccaaac acggtcttcc tgttccggac gggtttatta 3017761 ttcaaacgaa tgcgctcgca cgttttatgg aggacaacca gcttcaagag actagtgaaa 3017821 acgtcgaagg cgggatcatt tccggaacat tttcggatga gctgaaagat gagctgacta 3017881 gttcctttta taagcttaga gaatcatatc gatccgtagc cgtgcgttct tcgtctgctt 3017941 cggaagattt agaaggcgcc tcattcgcgg gtcaatatga aacctactta aatatcaaaa 3018001 cagaggaaga gtttctggct aaagtgaaag aatgctgggc ctcatttttt tctgggcggg 3018061 tcagcagcta taagaaaaaa atgaacaatc aaatcgcaga gccgttaatg ggaatagtcg 3018121 ttcaggggct gatcgattca gaaatgtcag gtgttatctt cagccgcaac cctgttaccc 3018181 atgatgatag agagctttta atcagcgcca gctacgggtt gggtgaagct gttgtttcag 3018241 gaaatgttac cccagacacg ttcattgtta ataaatcttc gtttgagatt cagaaagaaa 3018301 taggtgcaaa ggaaatctac atggagtctg cggcagaagg aattgctgaa aaagaaacga 3018361 gtgaagacat gcgcagccgt ttttgcctta cagatgaaca agtgattgaa ttggctgaaa 3018421 tcacaaaaaa aaccgaagac ctgtacggat atcctgttga tatagaattt ggaattgctg 3018481 atcatcaaat ataccttctg caagctcgcc cgattacaac cattgatcag gacaaaaaag 3018541 cggcagaaga aaaacgcagc ttcatgatta ccgacactga tatgaatgat ttctggctta 3018601 acatggagtc taatattgaa ggtccggtga gtccgttatt ttcatccttc atcgtgccgg 3018661 cattggaata tggcttgaag aagagcatgc aaaagtttcc gattggtgta gttgttgatg 3018721 aagtaaaact ttatcgcgga catatttatt ccaaaaacca aggcggacag cagcctcctt 3018781 ctgaagactg cggcaaagag cttttcccga ttttatcgga gcatatgtat gacatcatca 3018841 atcacacata cctccctttt taccggacac tggaccagct cgcacaaact gagcataccg 3018901 cagaaagcgc actggaagct tttcaaaaac taaaggcctt ttatctcacg gcttatgaag 3018961 agcactttaa tatcgttttc ccgcaaatcc ttttaacaaa caaactgcaa gcgatgtatc 3019021 aggacattca aggagagtcc gaaaacgctc atttttacga gatgctgaca ggaaaaatga 3019081 acaaatcact ggaaacggac cgttgcttat ggctattttc tgtggaagtt caggagaacc 3019141 cgaaccttct ggccattttt gaaaacaaca agcctgaaca gctccaggag aaattggaac 3019201 aaacagatga gggaagacac ttcctgaaga acgtccatga attcttgcaa gaatacggat 3019261 ggagatctgt taaaagtcat gatctgattg aacaaatctg ggtggaaaat ccgtatttcg 3019321 ctctggccaa tattcaaaat tatgtccgta atggctatca ttttgacaat gaatttcaga 3019381 aaacaaaaga aaaacgagag aaattataca atgaattctt ggaaagcata gaagatcccg 3019441 gtttacgcac cgaatttgac cgctattatc aatggacact gaactctgca aatataaaag 3019501 atgatcacca cttttatatt gacgccatgc tggatgccaa ggcgagaatc tttctgctga 3019561 agataggtga attgctggcg gaaaacggtg tcattcaaga tcgggaggac ctttggttct 3019621 tatatgacga cgaagtggaa caagcgcttc ttcaccctgt atccctgcaa gaaaaggctg 3019681 aaaaacgcag acagattttt catgagtatg agctggccca agccccggcc tacctcggca 3019741 ccccgacaaa agaacagctc aaagcagctg aagaaattgt cggcgctgtg atagaggatg 3019801 aaaaaaacac agagaatcat atttttggca ttgcggcatc aagcggcatt gcgacaggtc 3019861 cggtgaaaat cattcgggac gccaatgaat tttctcaatt cgcgcctgga gacgtactcg 3019921 tttgcaagat gaccacaccg ctatggacca gcctgtttca agacgccaaa gcgattatta 3019981 cagacacagg cggcattttg tctcacgctg cgattattgc ccgtgaatac ggcattccag 3020041 ccgttctcgg cacacgcacg gcaaccgaaa gactgcgaga cggtgacatc atcactgttg 3020101 acggaagcag cggcaaaatc acagttgtca gccggtcctg atgcgtcccc ctctttctta 3020161 tacaagcggg gcgggtgtat acttgtcctg ccagtatatt cgtgaggtga aacgtattga 3020221 gaccgacaaa caagagaatc cttgatgctg ccatgcagct gctcgtcaaa aaaggatatc 3020281 gcgcaacgac tacaaaagaa attgcagaaa aagcaaatgt aagtgaagcg acgattttca 3020341 ggaactttaa aaacaaacaa ggactagttg aggctttgct ttctcagcat tcttcaaaca 3020401 gaggcagcat tttggaacaa acagaagggg atttgtacaa agacctgctt catatcggaa 3020461 cctgtctctt ggaggagctc gaacatagaa aagatatcat taaaatcagc tttcgtgaac 3020521 cggccatgtt tcaggatgtc attaaccacg tcactgaata tccccaatct atgaaacagc 3020581 tattggttga ttatctcaaa acgatgggtg agaaaggggt tattcagaca ggaaatgaag 3020641 cggaacatgc cgacgtgttc atgtcgatta tcttcggtta tttcattcac cgtctccact 3020701 taggagaccg ggtcatatca atgccccagg aaaaaatgct ggagcatagc acagctctat 3020761 ttgtcaaagg aatttctgct gattaactcc ttggcataat aaaaaggagg atcccaatga 3020821 gctcaagaaa agaatgggcg ctgatcgtct cgctattatt gggggccatt ctggttccca 3020881 ttaactcaac gatgatcgcg gtcgcgctct catctatttc ccatacgtat aacgagtcca 3020941 tcgcaagcat cacttgggtg gttaccgttt atttaatcgt gatggcagtc acacagccga 3021001 ttgcaggaaa gctcggtgac atgtacggca ataaaacaat gtacttatgg ggagtcggcc 3021061 tttttctaat cgcatctcta ggctgcgccc tttcaccgag tctgctcctg ttaattgtct 3021121 ttcgggcatt gcaggctgtc ggcggggcat tgcttacgcc aaacagcatt gccattatcc 3021181 ggcatgttgt ttctgaaaaa cgcctaccga aagtgtttgg atttttcgga ctgggcgcgg 3021241 gacttggtgc agcactcggg ccttttatcg gctctatact gattgacagc ttcagctggc 3021301 attcgatttt ttgggtcaac atcccgttcc tcgccattgc tttatttacg gcattaacga 3021361 tgtttcctca atataaagaa aataaatctg acgcgccgct ggatatcatc ggctctctct 3021421 tgcttgcagg cagcatcgtt tccattatcc tgctgacgaa aaatgaggct ccatggggat 3021481 atactgtata cagtgtattg atacttcttt ttgttccgct ttttttcaga agagaaaaac 3021541 gtacccagca ccccatcatt gactttgcac tgtttaaaag ctcaaccttt acaaatgcga 3021601 atctatcagt cttgttaagc aatttgatga tgtatgccgt cttattgatt atgccgttat 3021661 ttatgacgaa ccaatttggg cttaatacat ctaacagcgg gatggcgctt tctgtatttt 3021721 cgatcttcat gtcagccagc aactgggtgg gcgcgcagct ccatcacaaa tggggagcca 3021781 aaaaaatcat ttttctttca tttgccatga tggctggtgc gaatctatta tttttgctgt 3021841 taagcagctc gcattctgtc ttgttcctca tgctctctct tatccttggc gggctcgctt 3021901 ccggagtcgg tctgaccagc atgcaggttt catcccttgc cacagtagac cccggtatgt 3021961 caggagtggc atctgggatt ttctcgacct tccgttattt cggaagcatc atttcatcag 3022021 ccttaattgg cctgatttcg ggatatcaca ccctatttat gattctcttt gctgtatcca 3022081 tcatcggcgt ttttgtttca ttgggcatca aatctgatga aacggcacgg atagaaaaaa 3022141 actcagcgta acacaaaaca gcccggcatc gcatcatcct gcggtgccgg gctgcctttt 3022201 atgatcccga agcgactgct tcgtcttcac ggtcatcctt tacgaagagg atgcccaatt 3022261 catgatgttc tccttcataa gaagctcgct ggtcaaaacg aatttctcca ttcaaaccga 3022321 taatttcaag ctttacatat gcacggttat gctgaagcgc ttcatagaaa tcagaaacgt 3022381 tcttaaccgg tatgccattg actttcgtta tgatttcccc gattttcaat tccagatcct 3022441 cagccggcgt attggggata atcccaagca ccattaagcc ctgatccctt ttcgagaaat 3022501 aaaacggagc cgcgttatca ttcactcttt gctttatgga cagaaaaata cgccctaaca 3022561 aagcggtaca gaccgctgca cccgcaagcg gcgtccacag taagctcgct gcaccgagaa 3022621 ctgcgacggc aagaccgaga atacaaacgc gtttcgctgt gatccttata ctcgtttcag 3022681 gcagcgatcc ctgtaccctt tgtccaaatc cgacaaagta aggaatccat agaaaatgga 3022741 atgagccgcc gggaaccgta aacacgggcc accagctaag gtgcgattct aaaccattac 3022801 cgggcacgag aaggaacagc ggcaaaagcc aaacccggtt tgccagctgc tgtccgatcg 3022861 gcaaaccgcg gctgcttacg acaagtgccg gtgatgttct cacatgcgca gaacgataag 3022921 caaccgctcc ttcagtgata atcagcaaac ctagaaacac agccacagcc ggccaaacaa 3022981 ctgcaaatcc ttgcggaaat ctctccagaa agggctccgc ctgatatatt tgcagtccaa 3023041 aacctatcag catactcaca ctgacgatat atgcagcaga catccagttt gcgcgaagag 3023101 tgaacgctgc cgctgcagtg ataacggcaa taatcgcaag taaaccgaga ggaatcgata 3023161 ttccgagtcc acctaaaata actgacaaaa gaagacctgg aatcagtccc tttgtatatg 3023221 taaatttcag atcatcataa atatctgcta ttcttgtatg aaaggttttt cgttcccgtt 3023281 tgattcttac atagccgaaa gccaaggtta tgatgataaa aaaccagaaa agcgggtgta 3023341 agaagaacaa gcccgcgctt tttaacagtt caattcccca ttgaacagac actatctctc 3023401 accgcctcaa gccaaacatg ttactcatat tctatcaaat attaaatggc ttggatatcc 3023461 tcaggagagt ttatctctct tgcgtcatcc acagcgtgac attcgatagt gaaaaatcct 3023521 ttaaatagtg gtttacatcc acatccaata acccgctgat tagatgcatc gaccttttta 3023581 tatctgtcag attaattcct aatcgcttat ggtttttcat taagtagtta aaataatgtt 3023641 tggcgcattc ctcattaatg tcatttactg attcgacatt ggtgtaattg accaaatatc 3023701 tgctgaacag cataagaaga cttagtgctt ttgtagctga aaatgttacg tcttgtgttc 3023761 tgtcttttaa ttgttccact aattcataat attttttttt cacgcacaat acttgccctc 3023821 ttcaattgtg aacccccatt ttctttatac agataagcac gggccagtat aagcagcagt 3023881 actggagtgc taacaagcat tctcgctaac gttactcttt aaatacctgt cgttcagctg 3023941 ccattaacct gattactgtt ctttttagaa ccttcttata ttgtatgaag taaacaaaga 3024001 ctaggcaact tgcaaaagtt tcattttaaa tgcatattaa ctcgttagaa agtctctctc 3024061 atatattgat atcgggtaat aacagtcctt tataaatgtt tatttgtgaa aattttttta 3024121 atttcttgtc aaaaactcat tttttatgtg acttatgatc cataatctct ttaagcacaa 3024181 agaaacagga gatgaaatac catctccttt aattgacaaa taatgatttc aatgctgttt 3024241 gaagctgcaa atcatttttt tcatctgatt ttttcttttc tatctgctga tttaatgtct 3024301 ctgcagtgcg agtgtcgatc acaccggttt tattcagctt gttttgatcc tgaaaagcca 3024361 taaccgcttt tttcatgtct ttgctgaaat agccatcctc acgtcccgga tcaaagctga 3024421 gaccttttaa caatacctgc gcatgcttga cgtcttcatt gttcatgtcc actttaagcg 3024481 gctctttcag ctgtaagggc ccggcggaaa aataatcggg ctgcttaatc gcaatggtcg 3024541 gttcaattcc tttcttatga atccagtttc catttggcgt cagccacttg taaagcgtta 3024601 atttgatgtt gctgccgtcc cccattggca cagcctgttg aaccgttccc tttccaaaag 3024661 acgtatcgcc tacaacatca taatggccag cttcctttaa tgcgccggca agaatttctg 3024721 atgcagaggc acttccttta tccgtaatca cattgacagg gtacgctttt ttatgggtca 3024781 atgttgaaaa ataacgtttt ttatctccat tgcgttcagc aatctgaata tacggctgat 3024841 cctttgtaac gaaatgctta agaatttctt ccacactttg aagatatcca cccgggttgc 3024901 cgcgtacatc aatgacaagt ccttctattt cttttttctc aagctccctc agcgcttttg 3024961 caaaatcctc tgcggtgtgc tcagaaaaag tagagatggc aatatatccg acagaatgcc 3025021 cctgtacttt tttctctgat gcaaaaaccg tttcgagcgg aatctcagct ctcttgatcc 3025081 ggaatgacaa ctgcttcttc gttccaggcc gctgaatctt cattgaaacg ctggaccctt 3025141 tttttcctct tatttttaac acagcgtggt ttaaatcctt gccggccatc gattctccat 3025201 tgatgctgat aatttcatca ttaggcttca acccggcttt ttccgctggc gatttcttga 3025261 atggagaaac aataataatt ttgccgtctt ccattccaac ctcagccccg atgccttcaa 3025321 atgaggaatc aagagaatca gaaaattgct tagctgtctg cttgtccatg taaacagaat 3025381 aaggatcatt tagcgtagac agcattccct ggatggctcc ctcgagcagc ttttctctat 3025441 ctactttttc tacgtactca ttcgaaatta actcatacgc tttttcgatt ttgtccatag 3025501 ctttatcccg ttcagagtca gcttgtgccg tcgcgggaac tgctgcagtc tggggcttat 3025561 ccatctcaag caggttgatt cccgcatata caccggcgcc tccgaacagc atgctccctg 3025621 ctgctatcac agccattatt ttttgattca tcctttactc ctcctgtatg ccagactgtc 3025681 tttaccaaaa cctagagata gtatatgtaa aggatggaga tttcatgtaa tcatagaaga 3025741 aaaagaaggc aaatgaaaag ccgtcccgaa aacggaacgg ctttttcact ttatactcgc 3025801 agaaacttgc ggatggaagt cagacttccc catactccaa ttactgcgcc gattgcaatc 3025861 agcactagcg aaacttggaa tacaaatgga ttataaggaa gaagagagac aaatgatcct 3025921 tgaacctttg gaacgaccca tccgatgacg tattggtaag tgctcagcac cagtgcaatc 3025981 ggaatcacag aaccgaatac gcctagcagc aatccttcaa ggaaaaacgg ccagcggata 3026041 aaccagtttg tcgcgccgac aagcttcatg atttcaattt cttttcttct tgcgaaaatt 3026101 gtaattttaa tggtgttgga aattaagaac atcgccgtaa ataccaggcc gataattaac 3026161 gcgattccga tgttgcggga aacgccgacc actttaaaca aacggctgac ctcttctttt 3026221 ccataagtga ctttataaac atgatccatt ttttcgatct ttttcgccac gttcggcgta 3026281 tcatgcggat ctgtcgtttt gacgacaaac gcatcattaa gcgggttttc ctgatccttc 3026341 attgtcaggg attttccgct gtcaccaaaa ctgtcaacca gctggtcaag ctctttttct 3026401 ttagatgaaa aagtgacact ctgaatgccc ttcagttcct taatatcgtt ctgaagcttg 3026461 tcctgtgcct tctgatctgc agtcagatca atcagcactt tgatttcgac ttgtttttct 3026521 gcattcgtgg ccatgttatt caaattcagc ataatcacta aaaacacgcc gactaaaatc 3026581 agcgtaacgg ttacagcact aatggatgca aatgtcatcc atgtgtttct cccgagagat 3026641 ttaaaactct cacgcaagtg gcgcccgaga attttaatca tatgaaccat actcccctct 3026701 tgactcatca cgcacaatga taccatcttc gattgcaatg acacgtttct tcatggtgtt 3026761 tacgatttct ttattatgtg tcgccatcac gactgttgtc ccgcggttgt taatttcctc 3026821 cagcgtcttc atgacttccc aggacgtatc cggatcaagg tttcctgtcg gttcatcagc 3026881 aatgacaaca tcagggttgt tcacaattga tctggcaata gatacacgct gctgctcccc 3026941 gcctgaaagc tggtcaggaa attgtcgcgc tttatgcttc agctgcacga gatcaagcac 3027001 ttcaagcacc cgtttcttaa tgacagacgg ctgttctcca atcacttcaa gggcaaatgc 3027061 cacattttca aaaacagtaa gtttcggaag aagcttgaaa tcctgaaaga caacacctat 3027121 tttgcggcgc acgaaaggaa tctctttttc tttaattgtc gcgagatctt tatgattgat 3027181 taaaatttgt ccttttgtcg gtttttcttc tctgtaaatc attttaataa aagtagattt 3027241 acctgctccg ctcggaccaa caacatacac aaactcgccg ggatgaatgg taacagaaat 3027301 cccattgagt gcttttacgc cgttcggata ggctttatat acttccttca tctctatcat 3027361 gaaatcacct aatcttttat atcattttat ctatcacacg gtcatactct tcgaatgcat 3027421 tcgacaattt atgacccatt catttgtaaa aagatgaaaa atctgaaagt tccctttttc 3027481 aatacacttc attatacgtc aaatttagac ataatactat tacagtttct tttcattcat 3027541 attgtcaagg cataaaaaca tccttgccag cactcggcaa ggatgttttt atcttacttt 3027601 ttttctgaca gccatttggc aataacagcg gcttcgttat catctacaag cccctttggc 3027661 atattgccgc ggccgttttt aataatgctt tcaattttgt gttcatcgta tttgcctccg 3027721 acctcttgga gattaggccc tgacacacct tctaaatcct tgccgtggca gcctacgcag 3027781 ctttgctgat ataattcttc cccttcagat gcagtggctt ccgtcttgct gccagtgtct 3027841 gtcttctctt cttttgcatc gtttgatccg caggcagcca acagaacaga aagcgcaaat 3027901 ccaatcatta gtatcgataa ctttgatttc atgttgagaa gcacaactcc tttacgatct 3027961 cttccatatt ataacctcgt ttaagcgcgt ttgaaaccct cgcccagcac ctcgctcgcg 3028021 tctgctacaa ttacaaaagc tgactcatca atctgtttga cgatttgttt caatttggtg 3028081 aattcagttt gcccaaccac gcacattaaa atcggacggt catcgtcagt atatccgccg 3028141 actgcagaaa tttttgtcac gcctctgtca atcttctgta agacagcctc cttgacagcc 3028201 tgctcctgct ttgtaatgat gagcgccatt tttgaacgat taaagccgac ttgcacaaca 3028261 tcaatggttt tgctggacac atagacgcca agcatggcat ataagccttg ctcaatatta 3028321 aatacaatca tagccgtaac aacgatcatt ccgtcaatga tggcgagaca cttccccaat 3028381 gacagaccgg agtacttatg aatgatctgt gcagccaagg ctgtacctcc cgtcgaacct 3028441 ttccctaagt acacaatacc aattccgata cctatcccga caccgccaaa aatcgccgcc 3028501 aggagttcat gatgagtggc gggctgaata tcccttgtca gaaacactac tagcggcaaa 3028561 aacacagaac ctgcaagcgt ctttagtcca aatttcccgc cgagcaaaat gacgccagca 3028621 ataaataaag ggatattaat aatccactgt acatacgctg cttcaaaacc atatgattgt 3028681 aaaatcgtac tgatcccgct gaccccgccg gcggcaatct tattcggaag caaaaataca 3028741 ttaaaggaca cggccgtaat cgctgctcct atcaatatgt atacataatc ccgcaaaatc 3028801 cacaatgttt tattccgtac gtccatcata tatcctccgt ttcttccaat gctctccgat 3028861 agcattttaa tccttccctg attagatgta aataacaccc aaatacagtg gtaatatgct 3028921 aaagcagcag tgaaatcaag gatataagaa ataaaaaaac acacccgtat gcatcaggtg 3028981 tgtttttcag cttatgaaag cttagaacgc aggtaggcat caataaacgt atcaatgtca 3029041 ccatccatta cagcttgaac gttccccatt tctgtattgg tccgatggtc ttttaccatg 3029101 gaatacggat ggaatacata agaacggatt tggctgcccc agccgatttc tttttgttca 3029161 ccgcgaattt catccagctc tgcctgctgc tcttcaattc tgcgctgata cagcttggcc 3029221 ttcagcattt tcatggctct ttcacggttt ttaatttgtg agcgctccgt ttggcatgtc 3029281 acaactacgt tcgtcggcaa gtgagtaatc cgaacggctg aatccgtcgt attgacgtgc 3029341 tgtccgcccg cgccgcttgc acggtacgtg tcaactttaa tatcctccgt acgaatatca 3029401 atatcaattt catcgttaaa ttcaggcatg acttcacatg aaacgaaaga tgtgtggcgg 3029461 cggcctgatg aatcaaatgg tgagatccgc acaagacgat gaacaccttt ttctgctttg 3029521 agatacccgt aagcgttgtg tcctttgatg agcaatgtca ctgacttgat tcccgcctcg 3029581 tcacctggaa ggtaatcgag agtctctact ttaaagccgc ggcgctctcc ccatcttgta 3029641 tacattctaa gaagcataga gccccagtcc tgtgactctg taccgccagc accagggtgc 3029701 agttctaaaa tcgcgttatt tttatcatac ggctcgctga gaagaagctg aagctcaaac 3029761 tcattgaact cttttgttaa tgactttagt tctttttcaa gctcaagctg gagatcagtg 3029821 tccggctctt ctttcaaaag atcatgagtc atttgtaatt cttcgtggga ttcattcaat 3029881 tttttatacg aattgacata atcctttaaa ccgtttgctt catttataac cgtttgagct 3029941 ttttgctgat cattccagaa ttccggatca gccatttgtt catctagctc agcaatgcgg 3030001 gcctcctttg attcgaggtc aaagagaccc cctaaagtcc gctaaacgag aagccatatt 3030061 ttcgagctct gctctaattt ctgataattc catttcattc acctcattaa aagatccgca 3030121 ggcgcctgca ggcgccgcgg tcagtaaact tgccggggcg aactattcag tacggccgca 3030181 gcaattttta tattttttcc cgcttccgca gtggcatggg gcatttcgtc cgatatcaac 3030241 cactttgcga accggtgctt tctttgcttt tttgttatcg tcgccttctt gcggctgatg 3030301 agctgttgtt tgaccttgta caacctcttc acgctccaga ttgttttcaa tctcagcttt 3030361 catcacaaat tttgcgactt cgtcctcaat tgattcaatc atatgctcaa acatcgcaaa 3030421 accttccatt tgatactcac gaagcgggtt cgtctgcgcg taagcacgaa ggtgaatccc 3030481 ttggcggagc tgatccatcg catcaatatg atccatccat ttagaatcaa cggcacgaag 3030541 aacgataact ttttcgaatt cgcgcatttg ctctttgccg aattgctctt ccttctcatt 3030601 atattttgtg atgatgcgat ccataatgag ctcaagcatt tcatccggtt ctttgccgaa 3030661 gatatcgctc ttctcaagtg caccttcatc aagataagtt gtgttgataa gatcaactag 3030721 accgtcaagc ttccactcct caggaagctc ttctcttggc gtataggctg caattgcgcg 3030781 ttcgagagaa gacttgatca tattttcaac gatttcacgc aggttttcag agtcaatgac 3030841 ttcaaagcgc tgcttataaa tgacctcacg ctgctggcgg agaacatcat catattgcag 3030901 aagctgttta cgcgaatcga agttattgcc ttcgacgcgt ttttgagacg attcaaccgc 3030961 gcgagatacc attttgcttt ggattggagt agagtcgtcc atgccgaagc ggtcaagcat 3031021 cgccattgtc cgctcagctc cgaatctgcg catcaattca tcttccatag aaagataaaa 3031081 ttgagtaatc cccgggtctc cctgacgtcc ggaacgacct cgaagctgat tgtcaatccg 3031141 gcgtgattca tgtcgttctg ttccgactac agcgagcccg ccaagctctt ttacaccttc 3031201 gccaagctta atgtccgttc cgcgccccgc catgttagtc gcaatcgtaa ctgcgccttt 3031261 ttggccggcc tcttcaatga tctgcgcttc acgttcatgg tttttggcat ttaacacttg 3031321 atgcggaatt cctttgtttt taagcagctt agaaatcaat tcagatgttt caacggcaac 3031381 cgtaccgact agaacaggct gtcccgtcat gtaacgctgt gcgacatcct ccgcaactgc 3031441 cttaaacttt ccttccatcg tgcggtaaat taaatccggg cggtcatcac ggacaacagg 3031501 cctgttggta gggatcgtga caacctgcat gttgtagatg ttgcggaatt cttcttcctc 3031561 tgtcttagct gtacccgtca taccggcaag tttttcgtac attcggaagt agttttggaa 3031621 cgtaatcgtc gccaaggtca tgctttcgtt ttgaatctca agcccttcct ttgcttcaat 3031681 cgcttggtga agcccctcac tgtagcggcg gcctttcatc agacgtcccg tgaaggaatc 3031741 aacaataaca acctgtccgt cttccactac atagtcaacg tccttttgca tcgcaacgtg 3031801 agcttttaag gcctggttga tatggtggtt gagcgcgaca tgcttcacat caaagaggtt 3031861 atcgatgccg aatgcttttt ccgccttcgt cattccttct tcagtaagct gtacagcttt 3031921 tgttttgata tcgtacgtgt aatccttctc cgcttttaac gtgcggacaa aagcatttgc 3031981 ctgtacgtac agcttagtgg attttgcagc ttgtccagaa atgataagcg gtgttcttgc 3032041 ttcatcaatt aaaatagagt caacttcatc tattaccgca aaatgaagcg ggcgctgaac 3032101 catctgctct ttataaagaa ccatattgtc acgcaaatag tcgaagccaa gctcgttgtt 3032161 tgtggagtaa gtaatatcag cggcataagc ttcccgtttt tcgtcttttg acattgagtt 3032221 taaattcaaa ccgacagtca aaccgagaaa ctcgaaaatt ttccccattt gctcagcgtc 3032281 acggcttgcc aagtattcgt tgacagtcac gacgtgtacg cctttaccgg ttaacgcatt 3032341 taaataaaca ggcagggtag acgttaatgt tttcccttcc cctgttttca tttccgctat 3032401 atttccgtca tgaagcgcca cgccccccat gagctggact ttaaacggaa acatgcctgt 3032461 tacgcggcgt gaagcttctc gaacaacagc gaaagcttca acaagaagat catccgttgt 3032521 cgcccctttt tcaagacgct ctttaaattc aattgtttta tgtttcaatg cgtcgtcaga 3032581 gagattttca tagtctccgc gaatcgcatc aatatcgtta gcaatttttt cgtatctatt 3032641 cagcgtacgt tttgttggat caaacatttt atttaaaatt ccaagcattt ataacgctcc 3032701 tctatcatca cacgcctatt ttagaggcat gtataaataa tttactagtc catgtatacc 3032761 tctcattatc atatcatacc ttttgttatt tccaaagaat ttgcaaataa gaaaaacaaa 3032821 aaccttccgc ggacatcacg gaaggcttct cttcattatt cagtcggttc aattaagcca 3032881 tatttcccgt catttctgcg gtacacgaca tttgtaaggt ttgtttccgc atttgtgaaa 3032941 acaaagaaat tatggccgag catattcatt tgcaagatcg cttcttcact atccatcggc 3033001 tttaaattaa agcgtttctg acggacgatg tccaagctct cctcctcttc tatgtcatcc 3033061 tgaaccgcaa tatctgtatc agagccaaga ccgtttgcca ataaatattt tggagagccc 3033121 tgctcacgga atttacggtt tactttcgtt ttatgcttac ggatttgacg ttccagtttg 3033181 tttgttgcga gatcaattgc gttgtacata tcctcgttat gcacctcgga ccgaagcgcc 3033241 agatctgtca tcggaatcgt aacctcaacc ttagactcct tgtcattgta aaacttcaag 3033301 ttgacgttca catcagcatc cacgctatgg tcaaaatagc gctccagctt gccgatcttc 3033361 ctctcgacat gatcctttaa cgcgggtgtc acttcaatat tttctcctct gatgttatag 3033421 ttcatcaaag aacgcctccc ttttattaag gatatgtatc tatttctctt ttacccttta 3033481 caattcctgc tgaaacataa atcttttgtg aaaattcagt gaactttgtc gaattttgtt 3033541 tgtatttgct ctgttattgg cggctgctaa gcttttgaat caaacagttt cattttgcta 3033601 cttttcggca gctcagcttt aattgatttg ctgtaattga agttattttc cttaggaacc 3033661 agcatatcgt acgaaataga gatgaattgc agcgcgtctc ttgtcagctg cctattcatc 3033721 tcatttactt ttttcagacg tccgagaact tgagaaagag attcgtatag ttgttccagc 3033781 tcttcctttt cactgcctga ggttttggcg atacatgcgg aaatagtatt attttcgcta 3033841 tatccgagaa aggccgaagt tgttttgatc cggtcatctt ctgtctgcgt gattgcttga 3033901 atatattttt gctcttttgt caaaatgtta gaaagctctt ttgttttgcc ggctttgagc 3033961 gcttccgtct tttcttcaga cagcgtgagc aggtgctcat gcagaacgca aagtcgcttc 3034021 aattgttcaa taattgcctt cgctgacatg ggctttctcc ttttttattg ctttttataa 3034081 aaattaatca tatttttcgc aatatgattt gcgtctactt tgtatgaccc gttttcaatt 3034141 tgcgctttaa gctgcgcaat tttttcctgt cgtgaaccag tgactgcgtc ggatgcatgt 3034201 tgcatttctt tagcctgtga tgaaatttca attttatctt gaggttgtgc aacagttttt 3034261 tgcaccgctt gcttatcata atttttttga tatggattaa cggattgtgt tccaaattga 3034321 ttgattttca taggattcct ctcgctttcc gttgcagtct ttaaacaatc ttaacccttt 3034381 tatcgactgc gttttcagtt agtttaggga atcagctgtt tttggtatta taggcatagt 3034441 atgtgtcttt tttactattt tctttctcga ttttcagagc atcctcgtgg ttcaaatgat 3034501 ccatttgatc cttaatatca gactggcaag ccttgcagaa cttgccttct ctaatcgatg 3034561 tcccgcacct ttcacaaggg tatgccaaat taggaagatg agtgatctga attcgcttct 3034621 gcctgatgaa tttcaatatc agctcttctt ccacacctgt ttcctcagtt atccggctca 3034681 aagttgattg ccggttttcc tgttttctta aaaatttata gacagtctca aatgattttt 3034741 cttcttcctt aatacacgcc tgacatacgg tttgcagctt tgtttttaaa aataaagcat 3034801 tgcatttcgg acaattagcc agttctccca tctttttttc tccttattag ataatatgcc 3034861 tgtgtcaatt tctagtgatt atatcggcat aaaaacagaa tcatttagct tctgatcaag 3034921 gtaaaagatg acactgaagc ggcttttcct ttttctaata agcagcgggc tgcgaagtgc 3034981 aaggtggcgc ctgttgtata aagatcgtct attaaaatga tattcatacc ttctgctgaa 3035041 ttattttttg tatcaaaaat gcactctgac agcaggcgtt ctgttttctt tttctttgac 3035101 tgtttctcat tattcaggcg aatgagggga tggtgggaag gccggtctaa acattctgcc 3035161 aagagatgtg cctggttaaa tccgcgctct tcttcccgtt ccttgctcag cggaataggt 3035221 acaagaacaa aatgcttatc ggggtaaacc ttagaaaagg ttgaagaaaa atcactttta 3035281 aatgcattta tgatttctgc atctcctcta aatttaaaac gggagagcgt ttctttcatc 3035341 atatcattat atgtgtaaac tgaacggttt tgacgcaata gcaaactgtc tctgatcctt 3035401 gttctccaca cctcgcaatc cctgcatacg gcatgaacag attgaggtct gccgcacagg 3035461 gggcagatat gtcctgtgat tttctttaat ttgcttctgc aagaataaca aaccttttca 3035521 tcaggcttta gtaaaaaaag ggctctccat gtaacatctt gagaaaattg cgaatcacat 3035581 aataaacaga tcagtttatg aatgcctcct cctgcttcgt ttgacataaa tcgcttggac 3035641 tctctgaaac tactgcagca gattcagcca aaatgacaag cattgctgtg tttttttgtt 3035701 tatctaccag ctcagctttc gtatatgcga tctttttaaa atcagtaacg taggatggac 3035761 tcactttgtt taaagaaagt gccaatacat cgttttggca tacttggcaa gtacaggcca 3035821 tatgaagctg gtccatatat cggtcgagca gttctttcat tacgatttct tttgaattga 3035881 caagcatttt tacagctcct catcatcggt tatatgagta tactgtacca cgttttcaaa 3035941 taatggctag tctgtacatt caacttttgc tgccaattca ttcatttctt ttatatgctt 3036001 tcttgcatcg agcatactct ttgttttgcc gaagtgaaag taaatgacat cgccgtccgc 3036061 atattcttta tgccggccgg ttcttcctgc aatttgaaca agtgcgcttt ccgtaaagat 3036121 agacgattcc gctcctagta cacccgtttg caccttgggg actgtgacgc ctctttccag 3036181 tattgttgtt gtgattaata gatcgagctg accatctctg aattgctgca ctttctcctt 3036241 tctatgcttg tcttccgcgt gcacagatgc ggttcggcaa tgaacacctt taaagcacgc 3036301 agcagccttt tccagaatag aaacggaagg aacgaataaa aaaacaggcc tcccttcttt 3036361 tacatgaaac tctatccatc ttttcaccgc tggcggaatt ttatttcggt ttaatttctt 3036421 cttccagttt ccacaccata caaagcgcgg ttcgggtaaa ggtttccggt ggtgtcttgc 3036481 ggggatgcga actgaatgta actgtccgtt cagtgctttt ctttttaatt ctttaggagg 3036541 tgttgcactt aaataaacga gggtgctgtt tttctttctt gctttttgaa cagcgaattg 3036601 aagggtttga tcagcagaat atggaaaagc gtcaacttca tcaatgatca taacatcgat 3036661 tgcatcttta tatcgcaaaa gctgatgcgt agtggaaatc ataagcggag atagccgccc 3036721 tttgtcatcg cttcctccgt aaagcgctga aatgtcagca ccctgaaagg cagccttgag 3036781 tcttggagca agctctaata caacatcggt gcgaggtgtt gcaatacata cacgcagtcc 3036841 ttgatttaac gctgattcta taccaggaaa cagcatttct gttttgccag cgccgcaaac 3036901 cgcccagatg aggagctctt ctttttttga tattgcttca attaaaacat tggcggcttt 3036961 ttgctgtccg cttgaaagct tgccatccca tgtcagctta atagacttcc agtttgattc 3037021 attttcctct ttccatgaat ataaaggaac ctcctcactc actctgccca tcatgacaca 3037081 ggaacggcaa tacagcttat tctttccaga tgagtgataa aaagaaaaat accgctgatc 3037141 agtttgtccg cacctattac atctatatct ccgtttattt atggatatag aattttcagc 3037201 agtgatatat ccattcttga tatgccattc aatcatctca tcggaaaatg agagctcagt 3037261 cctgagcaaa tgacggcttc gaagcgtctg ctgcaattct tttgaaaagg aactgttttt 3037321 ttcaactggc acattcacat agcacgcctc ctttcgaaac agtatgcctg aatgaatatt 3037381 ttctgtccaa ctattaaaat aagaatataa aaaaatctcc gctctaaaaa cggagatttg 3037441 gccttattta aaacaccagc aaattcctaa cgcaccttca cccaaatgag tgccgattac 3037501 cgcgccaaaa tagctgttat aaaattcaac atgaggatat tttgcagaaa gctcttcaat 3037561 gattttcgct gcttcttcct ctcgattagc gtggataaca gcagctcgca taggcaaccc 3037621 tttactcgca tcttcgtcta aaagctcata aattcgcgaa attgcttttt tacgtgtgcg 3037681 aatcttctca aaaggcacaa ttaccttatt gtcaaaatga aggataggct ttacctttag 3037741 aagactacca atgaaggctt gggcgctgct taatcgcccg ccgcgctgaa gatgggctaa 3037801 gtcatctacc ataaaataag ctcgaactgt ttttttcatt tcttccagtt cttttataat 3037861 atcttccggc gatgatgctc cgtttttgat taattcagca gctttaaggg cataaaagcc 3037921 ttgagccaag cagctgatct ctgagtcaaa tggatacaca tcaatattgt cgaccatcga 3037981 atcagccgct gctgcactgc tgaatgttcc gctgatcccg ctggaaagat ggatactgat 3038041 aaccgcatca taagacttgc caagctcttc atacaacgca accagctcgc cgattggcgg 3038101 ctgagaagtc gtcgggagct cattatgttt tttcacttct tcataaaagc ttttccagtc 3038161 caactcaatt tcttcacggt aagtctcctc cctaaaaaca acctggagag ggatcatatg 3038221 tatctgatgt tgttcacgca tttctttcgg aatatatgcc gtgctgtctg ttacgactgc 3038281 aatattcata gcttcgatac ctgccttatt gctttataac tctattgtaa gggaaacggc 3038341 agcctaaaaa aagacctgcc tagtaaaagg caagtctcct attatactat ctcatttcta 3038401 cccagccatt tttaatggcg accacaacgg cttgcgtccg gtcgtttaca ttcatttttt 3038461 gtaaaatatt gctgacatgg tttttaacgg ttttctcact gataaacaat gattcaccaa 3038521 taccgcggtt gctttttccg tctgcaagca tctgcagcac ttcacattcc cgcctagtta 3038581 aaatatgtaa tggtctgcgg atttcagggt aaacctcatg ttgagggtgt gcagaaactc 3038641 cgcttgttgc aaggcggcgg aattcgttaa cgaggttgtg agtaaccttc ggatggaggt 3038701 aagatccgcc ctcagccact actttaaccg cttcaattaa tgtatcagca tccatctctt 3038761 tcagcagata acctcttgca cctgttttca gggcatgtgt tacataattt tcgtcatcgt 3038821 gaattgatag aataattact ttagattcag gatacagctc tacaagctgt tttgtagctt 3038881 ccacaccatt tacgtttggc atattgatat ccatgatcac aacatcagga tgatagtgct 3038941 caacaatacg agccgcttcg tccccgtcat caccttcggc taccacttca aaggtaggtt 3039001 caaaatccaa tatccgttta acaccttcac gaaataactg atggtcgtcg ataataacaa 3039061 tgtttacttt agtcacaagc cacgcctcct tgtattattg ttctatatac tctagcattc 3039121 ggtcaatatg ccttttggct ctattttaca aatcatagtc aaagagataa cggaacctta 3039181 atcataataa atgtcccaag acctattttc gaatctattg tcatcgttcc ttccaataaa 3039241 tctactcttt ctttcatgcc cagcaagccg aatgatttgt ttttcttctc tttcgcttcc 3039301 ttcaggtcga accctttacc gttatctttt atcattaaaa tcacaaaatc ctttgtgatc 3039361 tcaactttga ctgtaatttc ttcagattca gaatgcttta gcgcattaga cacagcttcc 3039421 tgtgcgagcc tgaagagcgc aacctcaaac tgaggcgcta gcctctgatc ctctgtttct 3039481 ccaatgcact gaaaatgtat tttgaccttc ccgttatatt cctcggttgt atatagatat 3039541 tttcttaaag ttggaatcag gcctaggtca tcaagggcca tcggtcttaa atcatatata 3039601 atccttctca cttcgtaaag ggcattccga acattttggc ggagattttt aatttcttgg 3039661 aatccgtcct ctgcgccccg gtcacggaaa atccgctcga ttaattccga tctcatcata 3039721 acattcgcca gcatttgagc gggtccgtca tggatttctc ttgagactct ttttcgctct 3039781 tcttcctgcg cctcaataat tcttaagccg aaatcctgtt ttgcctgagc atcagcaaga 3039841 agcagtccaa cttcgcgcaa atcctgattc aagtagttga gcacaactgt aatttggctt 3039901 actaatgatt ctgaccgctc aatgatttcc tgaagcccta gcaatctgcg ctccaaatcg 3039961 tcccgccgtt cgcgcaattg cttctcacgc tgctggatca tcgtcaattc tacctgcagc 3040021 ttatgggctt tttcataagc attgcggatt tcctcttcac tgaatctatg aaaattacgg 3040081 ctgacctcgg ataaacggtt tctcgcatgg cgagtttgca cttcaagttt atcgccaagc 3040141 tcaatcactt catacacctg ctgtttaatt tgtttcagtt cttcgaccag ctgttcatac 3040201 tgctggcgtg actgctcccc gatttgaaaa acctcgtcct tgctcccgtc aacggttttc 3040261 agcatcttca tcaaaataga atccagcact ttggaatcca tctttgtttt attcataatt 3040321 tccctccgtc acggcgttgt catatatttt tattataaat gtaattgatc tgcaaattat 3040381 gtcgaattat aatgaaagaa tgcgtatatt ctagaaaaaa acatttttat atactatcta 3040441 ctctttatga taccaaaata cgcacaaaaa ttctaaagac tgtacgaatt tgtataggca 3040501 gtcttttatg cttagcagga gggtcagcta gcatgctgca cagctatttt actgtgaaag 3040561 aagcgggaga acacgagatt gttatagaaa aatcgcgttt tatctgtcat ttaagccgtg 3040621 tttctaccga acaagaggca caggaattta tacagaaaat aaagaaacag cactggaatg 3040681 cgactcataa ttgctcggct tatgttattg gcgagaatga tcatatccaa aaagccaatg 3040741 atgacgggga accaagcggt acagcgggag tgccgatgct cgaggtttta aaaaaacgca 3040801 ggctgaagga tacttgcgcc gtcgttacac gctacttcgg aggcattaag cttggtgctg 3040861 gcggattaat tcgcgcttat gggaaatcag tgtctgaagg attaaatcat ataggtgttg 3040921 tagaacggaa gcttatgcga atcatgcata cttctgcaga ttacacatgg cttggcaaga 3040981 ttgaaaatga attaagggag tcacaatttc tgttaaagga aatccattat tcagaaaatg 3041041 ttgaattcga aacatacgtg gaagaaaaag aaaccaacgc tttttctgaa tggatgacag 3041101 aactgacaaa tggaaagagt gatattaaag agggagagtt gacgtatctt gaaaaagccg 3041161 tcaatcacat aaaggagact gaataatggc tgaacgcgtt agagtgcgtg tgcgaaaaaa 3041221 gaaaaagagc aaacgtagga aaattttaaa aagaataatg ttattgttcg cccttgcact 3041281 attggtagtt gtagggcttg gcgggtataa actttataaa accattaacg ctgcggatga 3041341 atcgtacgat gccctatccc gcgggaataa atcaaatctt cgcaacgaag ttgtagacat 3041401 gaagaaaaaa ccattttcta ttttatttat gggaatagag gattacgcga ctaaaggaca 3041461 aaaagggaga tcagactctc ttattgttgt taccctggat cccaaaaata aaaccatgaa 3041521 aatgctgagc attccgcgtg acacacgtgt gcaattagct ggtgacacaa cgggaagcaa 3041581 gacgaagatc aatgccgctt acagcaaagg cggtaaagat gaaacagttg aaactgttga 3041641 aaacttcttg caaatcccga tcgataaata tgtcacagtt gattttgacg gatttaaaga 3041701 tgtgattaat gaagtcggcg gtattgatgt tgacgtgcct ttcgatttcg atgaaaaaag 3041761 tgatgtagac gaaagcaaac ggatttactt caaaaaaggc gagatgcatt tgaacggcga 3041821 agaagcctta gcatatgccc ggatgagaaa acaggataaa cgcggagact ttggccgtaa 3041881 tgacagacaa aaacaaatct taaacgcgct gattgaccgc atgtcaagtg caagcaacat 3041941 tgctaaaatt gataaaatcg cagaaaaagc cagcgaaaac gttgaaacca atattcgcat 3042001 tactgaaggt ttagcgcttc agcagattta cagcggcttt accagcaaaa aaatcgacac 3042061 attgagcatt acaggttctg atttgtattt agggcctaac aacacatatt actttgaacc 3042121 tgatgctaca aatctcgaga aagtcagaaa aacgcttcaa gagcatttag attatactcc 3042181 tgatacaagc actggcactt ccggtaccga agacgggact gacagctcaa gcagttctgg 3042241 cagcactggc agcactggca caacaactga cgggacgacg aacggaagca gctattcgaa 3042301 tgacagcagc acaagctcaa acaacagtac aacgaattca acaactgatt catcctatta 3042361 aaaaatgccc ggtcctttta gaggatcggg catttttgcg cagaaaaaaa ctccggcaca 3042421 taagccggag tttttaattc cttttcacca gccgtttata aaactttgta aacggcttaa 3042481 atttttcatt cacgagtcct gtcacttctg ctatgatttg cataaaaata atcaaaatga 3042541 agataataaa caaagaaagc caaattgtgg cacttttaag tacaatcgca ctgatactga 3042601 aaataaatcc aattaaataa ataactaaga ccgacatccg atgtgaaagg ccaaaggcca 3042661 tcagtctatg gtgaatatgc gacttatcag gcgctgaaat cggctgtttg tttaatattc 3042721 ttctgatgat agcaaatgtt gtatcaaaaa tcggtacgcc taatataata atcgggataa 3042781 cgatactgaa caatgtgaca cttttataca ggcctaataa tgaaagaatc gagatactat 3042841 accctaaaaa cagtgatccc gtatctccca taaagatttt tgccggatgg aagttgtaaa 3042901 acaaaaaccc cagcgtgctg gcaataacga ctaatgagag tgacagaatg agcacttttc 3042961 cgccggatag cgccatgaca gcaatcgttg acaggccgat aacagaaaga ccggcagcaa 3043021 ggccatccaa tccatcaatc aggttaattg cgttcgtgat gccgacaatc cataataccg 3043081 tcagcggata agccatccat cctaactcaa atcgttctgt taaaaaaggt actgagaaaa 3043141 agtccatttt taagccagtg cttacaatca taatggctac acctaattga atcaaaaact 3043201 taacttttgc acttaattga tatttatcgt caagaatacc taacacaata atgatgaatg 3043261 ctccgactgt aattgccgtc atccttgttt ctgtgtaaat accggatgca agcacgcctg 3043321 caaccacccc gataaatatg gccagcccgc ccatgcgggg catgattttg tcatgtactt 3043381 ttcgattgct gggctggtca actgcaccta ttttaatcgc aatccttttt acgattgggg 3043441 ttatgattaa aactgtcagc agcgagacaa taaacgcaac aacaatgcga atcatgcgtt 3043501 cgtcaagcat aaagaagtct cctttggaat taaatgaagt ctttatttat atagagaacc 3043561 gttccttcca ttataccttc tccttagtta ttataacaag cttcatcaaa aagaaacacg 3043621 tataatcaaa aaacgcgcat cccaatttat aggactacgc atgtttttga atccctgtat 3043681 atttcataat ttgtctaaat aagcaattcc aatcttgtgt ccgggcgatg tttcggcgca 3043741 tttctttata ggtctcgtct ccgttttgac cgagaacttt ttcacaagcg gctataaaat 3043801 caatcggatg atcgccctct acatattcgt atacatacgg cttttgcatt tttgaggttg 3043861 acggaagatt agtgcctaca acaggttttc ctgccgctaa aaattcaaat agtttcagcg 3043921 gaaacacagc ttgattatac ggtgattgtt tatatggcat aatgccaatg tcgataagct 3043981 ccatataatg aggcacttct tttggatctg ccggaccggt ccatatgaca ttgggaagcc 3044041 tcagcagctc ttgaaacgaa acatcaccat tggtggcatc cgggccaacc cataaaaatg 3044101 tccaatcagg cttttgcagt gccgcttctt taatcatttt aaaatcgagc ttcggtttaa 3044161 tcccgccaat aaaacctaac actattcctt ctctcccctg cagtatactg cgatcgggag 3044221 cttgtttatt tgcagaaaac agctcatact ccacaccgtt ttccacagta tgaacctttt 3044281 ctcgtcctgc agtcagtttt ttgtctactt ccttgtgaag ataatctgat gaacaggtta 3044341 ttgaatctgc tcgttgtata attctcagct ctgccgattt aatgactttt cgccggaatt 3044401 cagacagcag atttgatcgg ccgctgatcg gcgcagccca taggtcactg cagtcataaa 3044461 tgacctgatc ccaagaatac agcgaagaca gcagcgggaa tccgggaaac gtgtaccata 3044521 aacagcagcg ttcaccgttt gcagaagcag gtgtaagctc atcgagtaat ggggagagct 3044581 tatgtctgta aaagacatct gtatatcgtc cgaaacgaaa catttttttc tgcagcaggt 3044641 ctttgacagc gaattgcctg atgccagaat ggacttcctg aaactctttc ccttgggcac 3044701 gcggagccgg acatacccaa ataacttcct tcgtttcctc ctgagcagct aaaaattctg 3044761 ccagccggtg ccttctgtat ctcaattggt cttttcccca ttcagcagtg gcaacgatga 3044821 catgaatgat tgcttctttt gtttccacct tcatcacctt ttctctctgt ttgcagctat 3044881 aatctttttt tcaccgcgtt ttttgcatat tgaacaaaac accatgttgc tttcataaaa 3044941 tgaagccgtt cgatctccct gtagacaaac cacgtttttt tcgcagcctt ccatttgttg 3045001 ctggaaattg aattattgac aagccgatat tcagccaggc attcattcat tccataggca 3045061 gtaaatcctt tttttaaaag agacagccat gtggctaagt cctgtctcgt tctgatattc 3045121 ggcatttgga tctgtcccgt ttgctccctg tcaatcatca ccgtcaagca gccgataatt 3045181 gtatttttca gggcgtcatc gtacgtcagg ctttccggcg catgaataaa tttatcgagc 3045241 ggggtcccgt cctgcgccat taagctgtag cccgtgaaag agaacgcaca ggagcgctcc 3045301 atcataaact caagctgctt ttccagtttg tcttttttcc atttgtcatc actgtccaaa 3045361 aatgctacgt agcgcccttg agcgcgttcc aacgctttgt tgcgagcaac cgcagctccg 3045421 gagttctctt ccagatacac cacatgaatt ctttcgtcta ttttttcata ctgctgtaaa 3045481 atgtcgcggg tcccatccgt tgagcaatca tccacgataa tcatttccca atgaggatgg 3045541 ctctgatcta ataccgaatg aaccgtgtct tcaatatagt cacgcgcatt ataggaaggt 3045601 gtaatgacag atacgagagg tttccaattg gtcatgatca catctccatc gtatgatttt 3045661 aaaaggattc tctgaaaaat tcaggaatga caacgaacat aaaggcaatc gtaaggccaa 3045721 tcataacgcc gagaactgct ttctttttcg gagacatacc gccgcctgct gtctcactta 3045781 cggtttcgga atcagtaaca cttgccgctt tcaggttaag ctgtgtgttt ttgagttcat 3045841 ataaaaatct ctctttatcc actttggaat cctcgctcac cgactcgcct tcaagcgcgt 3045901 ctatgctgct gcggatgacg gcttctcttt ctgcatacag cttttgatcg tttttgagga 3045961 aggtggagga tatggcgttt aagacagatt ccgttctatc cttatcctcg tcactatagc 3046021 ttaaagtcag taacgatttg gattccgtat tgattgtaag cttctctttg atctctgcta 3046081 catcttcatc cttttcatca ggaagcgcct ccttcaaaaa ggagtcgctc tttaatagaa 3046141 gcggaatctc ttctgtgctg ttataaaccg gatgatcata gctccccaca gccaaagtat 3046201 cttcagctgt atagctcttt tgatcagcga tctgtgacgg caggatatac cccgccgcac 3046261 ctaatataat tggcaccgct atgatccaaa tgatattttt ttttatgcga cgggctattc 3046321 ttatcaatat atcgttcata taagtctccc tgctttttgt agtctgttta tctgtacatc 3046381 ggctcaggca tttgtctgga tcgccttaac acattcacgg cggcgatgac gagcgccata 3046441 aacacccaat ggaaaaataa atttgaaaca gagcttgggc tgatacttga taccaggaaa 3046501 ctgaccatag cggtaataag tccttctgtg atcagttttg actgattttc taattttctt 3046561 tcataaaact tgtaaagcac ccatatgagg taggcataaa cggacaaata tcccagcatg 3046621 atgaacaaac caaaattagc aagaatttca acaagccagt tatgcacctc tgccacattg 3046681 tcagtatcat atacagcata atgctcaaga taataggata catttcctgc cccgactccg 3046741 aatccgtatg aatcaaggaa aaaatgccaa gcgtttttca gcagatttgc ccgagccaca 3046801 tttgatggaa gcctgtcatg aaatgaatgc agcgtctgcg gggccagaaa cagctcccaa 3046861 aactttgaat agattttgct ggcgaaaaga actgcgaaaa gagcaattcc cgccgccgac 3046921 agccatatag ccattctctt taaaacaggc ggcaatacaa tgaagatgta gacagcaata 3046981 cctgcaaaaa tgcccagaag gctggctctt gaaccagtgg caaaaattaa atacaacgca 3047041 cagagcgaga gcacaaggcc aattgccttg atgtatccat tcttaatgtt tttcatcatc 3047101 gtgatgtaaa aaaagaagct gatggataaa aaggtcgcaa agtcattttg attaaaaaag 3047161 accgatgtcg gataatgctg cttgtactcc ggtccgctgt acaatgtgga actcgcaaga 3047221 tgatggtggg tgatatgatt gtaaaaacca atgatcatca gaaataccgt catcaccagc 3047281 caaatggcat aaacaatcat cagccgctcc attttttgca cgtacatgac aataagataa 3047341 atgaagaaga tccccattgc caataaggct aaatacttga ggccaactgt taccgacttg 3047401 gcccacagca gagaaacaag gccatatata aaccaaaagg cgaaaaagag taaaatccct 3047461 tttacttgca gcccatgcca tctttcaata tgggttcgat tccgaaccat gccgaaaata 3047521 tgaaggcaac ccgctgcaat gagcagaagc cggtaaagga acaaactgaa aaatccaaga 3047581 tgaatggcaa aaaatgcatt atttaaaaaa gtgcaggcga tcaaaatata gattacagcc 3047641 ataaagagcc gttcttttgt tgtaaatgcg gttgcaagcg tcagtaaaaa caggccaatt 3047701 gccaacaccg caagcacagc agccatctgc atgaaaccta tatctttatg gatggctccc 3047761 agcaatagga cgactccaaa tatagcagcg gccagtaacg ctagcgtatg gaccgctgat 3047821 cgtttgatac tcacatgttt aacccctttc ctgatgtttc aggagccggc ggccgagcct 3047881 agcagccggc agcttcaacc aagtaacact ttttcttttt ataaattgac gcttcccaag 3047941 tctttagcca attcttcaag cggcaagccc ggaaaatact tgtcagaggg ttccgttccc 3048001 cgaacagcgg gacggccgat agagtgataa atgtatccgg ctgcctgcat ctcttcaagt 3048061 gaaaataaat ttctgccgtc aatgatgact ggctgtttta agagggtttt cacttttaca 3048121 agctccattt ctttcacttc cggccaatcc gttaaaatca ggcatgcatc agtgtcttcc 3048181 atcgcagcat acacatctgt gtaatactcg acctgttcgc caaggatcgc tgaagcttca 3048241 ggaatagcaa tcggatcgta tgcttttaca tgggcgccca gctgctgcag cattgggata 3048301 atatcaagcg ctggagcgga tctcacatcg ttcgtattcg gtttgaaggc taatcccagg 3048361 actgaaatgg ttctcccttt gacgcttccc ataacagtca aaagtttatc tacaatatga 3048421 acacgctgct tttcgttcgt ttcaatgaca gcttcgatga gcttgaatgg atagcctgcc 3048481 gattttgcga tttgaagcag cgcggttgta tcctttggaa aacatgaacc gccgaatcca 3048541 ataccagctt taaggaactt tctgccgata cggctgtcaa gaccaacacc atcagcaact 3048601 tttgaaacgt ctgcgccgac tcgctcacaa atgtttgcga tatcgttgat aaaggaaatc 3048661 tttgtcgcca gaaatgcatt cgcggcgtat ttaatcattt ctgcactttc taggtttgtt 3048721 ttaatgacag gagcatggaa tggctgatga agttcctcaa tgatggcagc ggctttatga 3048781 cttgttgaac caatcacggc acgctccata ttcatcgtgt catgaatcgc tgacccttcc 3048841 cgaaggaatt cagggttaga tacaacatca aatgagtatc tcccctttga ggctttttga 3048901 acgatagatt gcaccagttt ccctgttcca accgggactg tgcttttatt tacgatcact 3048961 ttgtagccgt taagatgctc accgattgtt ttcgccgccg ctttgacgta cgttaaatca 3049021 gcttcacctg ttttggacat aggcgttccg actgcaatat aaataatatc tgaggcccga 3049081 atggcagacg ggatatcgtt cgtaaaggtc aggcgctgat ccagcacatt tttttcaact 3049141 aagtctgcaa gccctggttc atagattggg attaccccat ttttcaggct tctgattttt 3049201 gattcatcga tatcacagca aacaacttta ttgccgatct ccgcaaagca agtgcctgat 3049261 acgagtccta cataacctgt tccaatgaca gctatttttt tcacagcgct caaccctctc 3049321 ctgtaaaatg atcttccaat ttataatggt cgcagtgtct tacgattaaa cggacgtttt 3049381 cgtgaccgtc tgatactgat gatgcaaggc cttggcgttt tttcctgcgt caaattgagc 3049441 ctgcacggtt tcatacaagt catctgctac ttccggcttc catatttgct catgttcgta 3049501 ccgagtgatc gcttccgcca aggcttgagc ggatttcggt ttaatcagca gatgttggtg 3049561 ctttccgaat aaagacgaca ctccgccaac atccgtacaa ataacaggaa cccttagcgc 3049621 cagcgcctca atcacaacag tcggcatccc ctcactgtaa gaaggaagta cgaatagatc 3049681 tgccgcaagt aaatagtctc ttacctgatg attcgggact tggcctgtga cgatatgccc 3049741 cttctgcgtc agcgtcgatt ttgcgggacc atccccgaca aagactgcct taggagagtc 3049801 ctgcagcgat tcgatcgctt cagacagttc aaaaatgcct ttctctctga ccagccggcc 3049861 gacatagaca gccagacgct gatcgagcgg gagtccgagt ctttttctga tttcctcttt 3049921 cgtctcctca ttcccctgaa aacggctgag ctgtatgccg attggcaaaa ccgagctgtc 3049981 aaagcccgaa agctttttgg cttcttcctg aagcttgtgg ctgactgcta aaacaactga 3050041 cgcagaacct acggcacgct tgaaggcttt aaacgcacct ttgctgtaat gcggatagac 3050101 attcacatca ctgccatgca aggtcaggac ataaggaatt tgcgctgact ctgacacgac 3050161 tgccgcagcc ccgcccgatg gcatggcaaa atgcgcatgg atcagatccg gatataggtc 3050221 gcgctgtttc attgttttta aaacggctga tgcgattctc cgatgaggct gcgcccactt 3050281 cagctggccg ggaactgccc gatagaaagg ccggtaaacc ggtatcccct ttctaatctc 3050341 atactccggt ctgacatcct tttttcgata tgtctttttc agcatgcgga caggtgctga 3050401 atgaaaaggc cgtgggcata tcacagtgat atcaagcccg agtttttgca gctcttgcac 3050461 ctgtgtctca tgaaacacac cctctccggg tttcatactg ctcggatata cgcttgtgat 3050521 ccacaaaatc ttcatgacaa acgtcctttt cttagtagtt tgcttttcgt ttgagggtac 3050581 gcttttacca aaagaaagag atagcacagc gccccagccg caactgaaat ggccagccgc 3050641 atttctgcct gcatactgaa gtgttcggta ctgaggctta caccaaacgc gatgatgccc 3050701 atcgccgcag taatcagaaa tggcttcata atcgactgga aataagctga aaggttaagc 3050761 ttgatgacat atgccaaaag ccagcgccca atcaggaaat taacaacgct gataatggca 3050821 tacacccatg cgactgtcag caggcttccc gtctgtacag ctgcaaacag tgataatccg 3050881 tacagcagca gcacgccgga atcccaataa aacgctaagt cagctcttcc tttagccagc 3050941 aacacagatc catttggatt catgagcact cttagtattc cgacaatcgc aagaacattt 3051001 aggatcggaa cagcagcaag ccatttttct ccgaaaaccg ctgtgataaa ggcgtctgac 3051061 acagacacga gcccgattaa cagcggaaac gaaacaagcg ccagcatttt tgtcatattc 3051121 agaaagcctt ctctgatcac gctgttttca tatttgtttt ttgcgaaaat agggaatgcc 3051181 acccgtgtga caatcggatt gatcttcaaa accggaatgg tgacaatctg ataagcgagg 3051241 ttataaatcc ccaatgcttc agcaccaata aaccggccga tcaaaatcat gtcgatattt 3051301 gctcccagcc tgttcacaag acgggatgaa agctgaaagg ctccaaaaga aaagaaatcc 3051361 ttcatgcctc tcaaatcaaa aacaaaagca ggatgccact tttttcggta tacagcccaa 3051421 tataaaatcc ctttactgga ctgcagcagg acttgagaaa tcacgtacgc caaaatcgca 3051481 tccatcataa aaaccgctat cgctaaatat ccgaatgaca atacatttga aaaaatctct 3051541 attttgctta acgtattaaa atgcagctgc ttttgcagca tatactgata ttgctgtcca 3051601 attggcgcga tcaaaaacat aatcgccaga atccgaacca gaaacaccag ctcttctctt 3051661 tgataaaatc ccgcaatgac aggactgctc acatataaaa gaacaaacag caaaacgccc 3051721 gtcataatgt taagccaata caatgttgac agctggcgct ccgtcgcgtc gtctctctga 3051781 attaatgctg cgccaaaacc catatcgagc acaatctggg cgaaaactgt aaccgttgtg 3051841 atcatgccga caagcccaaa ttctgttaag gtcatcatat ttccaagcag ggcaaactga 3051901 acaatttgta tgattgtaat acacatggtt gaaatacttg tccactttgc accgctcatg 3051961 atttgttttg taatacttgg catcatattc cctacttctt tttaagctca gattgatggt 3052021 gaataatgga atcccgtttt atcttgcacc atcacccgtc caaactactt tacaagtttt 3052081 taacataatt tttaattcta aagtgaaagt cagattgcga atgtaatata aatcaaatat 3052141 cagcttttcc ttcggcgtca tatcgtaacc gccgttcacc tgagcccaga cgctgtgtaa 3052201 agcctggaat ctcattctgg aatttttccg taaatacggg ccgttccgga cgagggccaa 3052261 tcatactcat atcgcctttc agcacattaa acagctgagg aagctcgtca attctcgttc 3052321 ttctgataaa agctccgatc cttgtcaccc gcggatcttg cttctgtgcc caaaccgccc 3052381 cagacttctc ggcatctatt ttcatggaac gaagcttata aagcttaaat ggcttcccgc 3052441 ctttccctac gcgttcctgc gtataaatgg caggccccgg cgtctccaaa caaatcaaaa 3052501 ttgaaaatac cgcaatcatt ggcagcgcaa tcgccaatcc aatgagcgca aaccaaatat 3052561 ccattacgcg ctttattgcc aaataacgag ccgtcttttc agataatgta aaagaatgta 3052621 tttgttgaac tgagaattca cgactcacat tcatgctttt ctctgcactc actgacacac 3052681 acctcacgat ttgtttggga tgttatgatg acctatgcca gtcagtttag cagacggatg 3052741 ttaattggat gtaaatggta tgttaagaag tgtgaattac gtgttttttc tgataaatgt 3052801 tgttaatact cttttactat tttatataca agtcctattt gttttaatca tttcatataa 3052861 aaaagagaca aatctgtgat tagatttgtc tctttcgatt atctgtaata agatactgtg 3052921 ccgtcatgaa tagcttgtgc agctttatct ttataaaccg cttgcttcaa tttacttgca 3052981 tctgatgcat tagtgataaa ggcagtttca actaaaacac tcggcatttt agaatattta 3053041 ataacataga aagcagctgt ttttactccc cggtctctcg ttccaagatt agccgctaac 3053101 tttggttgaa tttgttcagc cagtctcttg ctatttgcag cttgatatgt tgtatcgtag 3053161 tacgtctcac ttccatttgg tgatgagcta tcattagcat ttgcatgtat actgagaaat 3053221 aaatctgctt gtgcagaagc tgctttattt actctctcct gtaaagaata aaaagtatca 3053281 ttagatcttg acagtactgg aagagcacct gaagcattta gctttgtatt gactcttttc 3053341 gctatatcaa ggttgacttc tttctcaagg agtccattgc cgattgctcc tgaatcttga 3053401 tcaccgtgac ccggatcaat aaagattgtt tcacctacaa ctggattctt tagctgatta 3053461 gcaacctttg tgcttacggc aggagtgttt ccgataatca taaagtttga catgttttta 3053521 cttccaataa ttttacgggc tcctgtagat aaattttcac catttgtaag aataagagat 3053581 tgcttcttct tagctgccag tgtagctcct gcaatagagt cagggtagct gaatccattg 3053641 cttacatata cggtgcttgt tgataaatta agtttttgta cgatatttgc agcaagctca 3053701 tatctgtttg aaccgctaat tcttgtagga gaaggtaact tgttgtatac cgtattgctg 3053761 atacttccag tgcctcctac aacaacggta ctcgaaattc ccttatcttt tatcacagac 3053821 gtagtcgcac tatttataga tgttttattt gtaaaaagaa ttggataccc gtttttcgct 3053881 gcataaggga tgacggccgg agcgtctgca tataagaagc cgttcaaaat aacagctttt 3053941 gaagtcgcac ccatcgcttt tgccacccgt gcagccgtat cataacggtt gcttcctgca 3054001 attcgtttaa tacttatccc caagctttta atctggttag cagtgttaga agaaacagca 3054061 ggtgttccgc ctacaataat tacattttta gtctgcatct ctttcaatct tgttttcgtt 3054121 tcatatgaaa gcttatcaga attagtgtaa agcaatggcg cattcttctg gtaagcaaga 3054181 ggtgctgctg aaatagcatc tgcataggaa ctcccaccaa caattacagc tgtacttgct 3054241 gttgaataca tttgctttga tatttgtaca gcagtgccgt atctattgct tcccccaact 3054301 cttttcactg agttatcggc caaagctgtt ggcacaaaaa gtatgagccc cagaaaacac 3054361 attgttagga cttttatata agaacgcaat tgatttcctc cttaaatggc gttatatcct 3054421 aaaataatca ataacttgtc agagttgtac ctggatagta aaatttcaaa attgaactat 3054481 atgaatctcc agcttctgct cttgcttttg ctccatattg actcattccg atcccgtgac 3054541 catatccttt accgctgatt gtgtactttg aagtatcttt ttttacagtc acataagtac 3054601 ttttaaatac agtcgctcca atcattgttc ttaactcact tgttggtaca ctaatggttg 3054661 taattttgct caagttatag gagccagtac tgcttttaac aaaatacttc actttcatcg 3054721 atgctgtttt tgcacgctgc ccttgtgtcg ttccactaaa gcttaaatcg tcaatacttg 3054781 caattttgac agaatcagcg cttgtttctt tatttttcaa gatccagttc ttaactccgg 3054841 aaagtcttgc agaatcagtt tcagtcgctg aagaccacca agaagaaggc ttcgttaagt 3054901 ccaaagattt cgtatctagc tgttgttttg acaaagtaag cgtccagcct atttgaggat 3054961 cctttgtatc tttttttgca atcaagtaag gtacacttga cgaccacact tcattactag 3055021 cttctgtgta accaccatta ctggaagaat aagctgcagt tataagagat ccattatatt 3055081 tcagaacttt ccccttcgtt tgctctaccg ctttattggt attcgaattc caactgtagc 3055141 caccataaac ttgaaaagcg gttgtatcag gtacagtagt tcctgttttt gttattgagt 3055201 aggttcttgc agcgacagtc tgtgctttaa gagcctcaag tgaccagcta gcaggcattt 3055261 cattcggaat tactcctttt aagtaatcct caaatggaat attctcattt accggtcgga 3055321 tatatttagt agactcaata gagaaattaa ccgtgccaag atactgcttt ccatcaagac 3055381 taattctgtt tgaagtagaa tagttttctg gtttaattct tagggagttt ccgtaagttt 3055441 tgatgttttc aaggtttaat tttccgctgt tgatttttag attataggtg ccaccgtcag 3055501 ctaaataaaa ttcatcagca agtgaattct caacttcagc agaaattgaa ctggtacttc 3055561 caataaagtc gtatgcatat gtggctttat ctttcgttat acttttagcc gcagccggaa 3055621 cgctatcttg tttaacaaat aaaatttggc tgtttttctt cgaggcaagc gaagcgccta 3055681 tcaatacgtc tgcatatttt gtcccgttcg tcattacgac tttatcagcc ttcaacttta 3055741 gttgcttaat tatatttgcc gtaagttcat atctggttga tccaggaatc ctttgcacag 3055801 ttgaagtttt tttaatttgg ttttctacac tatcactgac gctaaatgaa ctgcctataa 3055861 tgatgacttg ttttggcaaa tcataatccg gaagcttgtc tttctctgta agcaaaatag 3055921 ggtatccgtg tgctgctgca tatggagcaa tggctaaagc gtcttgaaat actcttccgg 3055981 ttacaacgat cgctttatca tagctgccca tttgctttgc aatattttct gataagacat 3056041 atctattttt tccgcttatc cttttcacag cgccatatga tttcagcttg ttttctacgt 3056101 cttttgaaat gcttcgcgct cccccaatga ttaaaatatt atcagggtta aacttagcaa 3056161 tttgtctttc agtagttttt gttaacgtgt caggctgagt aaataaaact ggtgcgttca 3056221 gttttttcgc caatggaata acaggcaatg catcaataaa aatatctcgg ttcaccaata 3056281 tcactgtatt aggatttttc cactggctgt tggatgcaag agtcgcagtt tcgtatcgtg 3056341 aagcgcctgc aaaacgatcc gtaacagcaa cattatctcc agttacttta taaaatcctg 3056401 ttggcgatag actgatgcta gatttatttc caatataatt taacaattta actgagatgt 3056461 ttgagtctgc tgcaaaagaa actgatggaa tcaataataa gattgcagca agtgaacaca 3056521 ctatcaattg tttgcaagat ttcaaaattt caggttcctc cctatatctt agttggcacg 3056581 ttcaatatct tttaacagaa gctgaccctc atcatttttt tcatatgtaa tcgtgacctt 3056641 atctccactg ttaaacttat caagatcact tgtcgattct tcagtgatat caagactaac 3056701 cggctcatta tctactgtta cttctattgt atgagtatca gctaacccta cataagtacc 3056761 ttcttttgtt tcaatgttac tgtctggcga tacatcttca ccttgactct tttgactatt 3056821 aaccccgcaa cccgaaagaa gcaatataaa gaacagtaaa gcaataaatt ttttcatttt 3056881 tttcacctca ttatatttta tcgtcaacct attttatatt ttaaagaaaa attaagaaac 3056941 aatgaaactt ttttttataa aaaacgacta ttttaggatt tcattcttgt attaaataga 3057001 gttgtattta ttggaaattt aactcataat gaaagtaatt taacagacga ggtgcaaagg 3057061 atgagaaacg aacgcagaaa aaagaaaaaa actttattac tgacaatttt aacgataatc 3057121 ggacttcttg tactcggaac tggcggctat gcatactact tatggcataa agcagcttca 3057181 accgtggcaa gtattcatga aagcattgat aaatctaaaa agagggataa agaggtcagt 3057241 atcaataaaa aagatccttt ttccgtctta atcatgggtg tggatgaacg cgacggcgat 3057301 aagggccgtg ccgatacgct catttatatg accgttaacc caaaaacgaa tacaaccgac 3057361 atggtcagca ttccgcgtga cacgtataca aaaattatcg gaaaaggcac aatggataaa 3057421 atcaaccatt catacgcttt cggcggcaca cagatgacgg tagacactgt tgagaacttc 3057481 ctcgatgttc cggttgatta ttttgtgaaa gtgaacatgg aaagctttag agacgttgtt 3057541 gatacacttg gcggcattac agttaacagc acattcgcgt tcagttatga cggttattcg 3057601 ttcggcaaag gagaaatcac gctgaacgga aaagaagcgc tcgcttatac ccggatgaga 3057661 aaagaagatc cgagaggcga cttcggacgc caggaccgcc agcgccaagt catccaaggt 3057721 attattaata aaggcgctaa tatttcttcc atcacgaaat tcggagatat gtttaaagtt 3057781 gttgaaaata atgtgaaaac gaacttgacc ttcgataaca tgtgggatat ccagtccgat 3057841 tacaaaggtg cgcggaaaca tattaaacag cacgaactaa aaggtacagg cacgaaaatc 3057901 aatggaattt actactacca agctgatgaa agcgcccttt ccgatattac aaaagagctg 3057961 aaggaaagcc tcgaaaagta aaacaaaaag aagcttcgca caatgtgcaa agcttctttt 3058021 ttatttgcct gtaaatgaat ccggttgttc ttttcgatac ccgtaatgaa acagcaattc 3058081 ttccacaatc cggcgggaag cctctccatc tccatacgga ttagaagcct gggacatttt 3058141 cttgtactca tcaggatcag ttaacagctg ttttgcaagc tgataaatgt tttcctcatc 3058201 cgtacctgca agtttcagcg ttcccgcttc cactccttca ggccgttccg tcgtatcacg 3058261 cagaacaaga accggtttcc cgagagatgg ggcttcctcc tgcacgccgc ccgaatcggt 3058321 caatataaaa tgcgatttcg ctgcaaagtt atggaaatcg atcacctcta aaggttcaat 3058381 cagatgcact ctgtcagaat caccaaaatg cttatgagcc gcttcccgga caacaggatt 3058441 caggtgcaca gggtaaacga cttgtacatc ttcaaattcc cctacaattc tgcggatggc 3058501 cttaaacatg ttttccattg gctcacccaa attttcccgg cggtgagcgg tcaagagaat 3058561 cattttatcc tcacccacct gatcgagaac aggatgtgag taaccatccc taaccgttgt 3058621 gttgagtgcg tcaatcgctg tattgcccgt tacaaaaata gagtcggcct ttttgttttc 3058681 ttttaataaa ttgtctttcg cctggcctgt cggagcaaaa tgcaaatcag caatcgcccc 3058741 tgtcatctgt cgattgagct cttccggaaa cggggaatac ttattccctg tacggagccc 3058801 cgcctccaca tgaccgacag caatttgatg gtaaaaagcg gctaggcttc cggcaaacgt 3058861 cgtcgtcgta tcaccatgga caagcacaat atcgggtttg atatctttaa acaactcatc 3058921 caatcttaca agtgcgttag acgtaatctc tgccagtgtc tgccgctcct tcataatgtt 3058981 caaatcgaag tcaggcttga tgtgaaacgc atctaacacc tgatcgagca tctgtctgtg 3059041 ctgtgcagtt accgttacat aggaatctat ttcaggatat tttttcaatt caagcacaag 3059101 cggtgccatc ttgatcgctt caggcctggt cccgaaaacg gtcatcactt ttagtttttt 3059161 catatttgtc acctggtttt ctgctatagt aaataaattc atactacata ttctacatga 3059221 aaatgcatca ttttaaatca tttcattctt gattcaaata aaatgatata agttttaata 3059281 ttaaggataa agcttgttta aaaatggttt atccgatatc ataaaaatgt gtaaaaacat 3059341 attgaaaagg gtaaatagag aatagtttaa ccataaattt tttcgatcat aaggaaggtg 3059401 ccttttaaat gaaaaaagta cgtaaagcca taattccagc agcaggctta ggaacacgtt 3059461 ttcttccggc tacgaaagca atgccgaaag aaatgcttcc tatcgttgat aaacctacca 3059521 ttcaatacat aattgaagaa gctgttgaag ccggtattga agatattatt atcgtaacag 3059581 gaaaaagcaa gcgtgcgatt gaggatcatt ttgattactc tcctgagctt gaaagaaacc 3059641 tagaagaaaa aggaaaaact gagctgcttg aaaaagtgaa aaaggcttct aacctggctg 3059701 acattcacta tatccgccaa aaagaaccta aaggtctcgg acatgctgtc tggtgcgcac 3059761 gcaactttat cggcgatgag ccgtttgcgg tactgcttgg tgacgatatt gttcaggctg 3059821 aaactccagg gttgcgccaa ttaatggatg aatatgaaaa aacactttct tctattatcg 3059881 gtgttcagca ggtgcccgaa gaagaaacac accgctacgg cattattgac ccgctgacaa 3059941 gtgaaggccg ccgttatcag gtgaaaaact tcgttgaaaa accgcctaaa ggcacagcac 3060001 cttctaatct tgccatctta ggccgttacg tattcacgcc tgagatcttc atgtatttag 3060061 aagagcagca ggttggcgcc ggcggagaaa ttcagctcac agacgccatt caaaagctga 3060121 atgaaattca aagagtgttt gcttacgatt ttgaaggcaa gcgttatgat gttggtgaaa 3060181 agctcggctt tatcacaaca actcttgaat ttgcgatgca ggataaagag cttcgcgatc 3060241 agctcgttcc atttatggaa ggtttactaa acaaagaaga aatctaaaca aaaaggctat 3060301 tggacattca tccaatagcc tttttttatt tcaacatcaa agtcaatgta tgctcttcat 3060361 tatcaactgc gaagacctga tcaacggcct gccgcaaaaa ttaataatcc cagacaaaca 3060421 cactgattgt agagttaaac aaactaaatg aaaacataaa tacaaacatg cagattaaat 3060481 agtaaatatc ttgtattcaa tgcaagctaa gtaaacacca cttgctaaaa gaacaatgac 3060541 taaacaacca gcattacaaa ataattaaat aaatttgaag caattacaac agaaggcagt 3060601 gaactgtcgg aaagttcatt ttggctacca tattaatccc tttaactacg ctgttggatt 3060661 tatcaagaat tgtcgggcta atagaaaacc acggaatcaa accagccagc attcaaacga 3060721 taaaaggcac ttctccgata cctgttatga ccagcttact gttgcgcatc ccaaatacaa 3060781 accagtacgc catcattaga ataaggggat ttaaaacctg ccataataca ccaaaataat 3060841 tgattttttg gatctttcgg ttaaagaaat ttaaaagtac cagtgaatat tgtaacaaat 3060901 gttgagtttt tttcactttt aaaaagtaaa gagaagtctc gcagaacttc tcccaacatt 3060961 tgaagtgtca atataaaaca aaccaacctc atttagcaac tttattatta tctaattcca 3061021 aaatagcatt ataaatacga ttcctattat ttttatcagt atatgcaaaa aagttatcta 3061081 ctctttttct atacttatct tccatacgac tattgttttt catataatag ataactttat 3061141 ccactaagct attatgattt tctaatacat caccaaaccc cattttttta taatcataat 3061201 aatcaagttt aaaatggtat gacttttcgt attgataata aataacaggt tttttctcat 3061261 atgcaaaatc aaacgcaaca gatgaaaaat cagtaatcat tatattagaa gaattaaata 3061321 gcatttgata gctgctgtta tagtcggcaa actccacata atcatgcttt tcaaagtcta 3061381 caatctgttg ctgaatatct gggtgaggaa aaaaagttat tttataatta tttttcttag 3061441 caaattcgat tagccgttca tcattaatca aagcattata cctagaaaaa tattcactat 3061501 ctttaaattt cgggttgtac ggtcttactc cttttgcctg atctttcggt aatacaatat 3061561 cttttctcca agtcggcatt attagaagtt gcttttctcc ctcactcttc ttaagattat 3061621 cgtatctcgg aaatccaccc aacaaaatat tctctttttt atagttgtaa ttccctttca 3061681 caatagaccg atattcaggt ttggcagaag tgactaataa tttgatattc ttgttgtatt 3061741 tgtttaacca ttcagaatga tctgccattg ttattccgtg ctgtaaaaag ataaactcaa 3061801 agttaaataa atctctaaaa taaatctcca tattaaaaaa tggatttaca acccatatat 3061861 ctgcatgtgt cgatattact ttggaagagg ataaggttaa aattttatgt ctaaaagatc 3061921 tgtatggtat gacctttcca tattttttga ttctgtcgta atccttgcta tcttttttta 3061981 ttataaagta tttttttacc ccatcattct tgttgattgc atatttaaag aggtgctcgg 3062041 cattatcatc agctttgtct tgtctgtcta tgaataacca tactggtttt ctattaaaaa 3062101 tagtgaaaac atggtgtacc attcttgcca tcagtgcctt cttaatcgct gattttcgtt 3062161 tttttgattt ttcccctgat ttatgtaggg attttaagaa acgaaactct tttataaatc 3062221 tatttttaaa attgtttttt ttgaacatta attttttata attataataa aaaatataat 3062281 cttttttagc cacataagta ttatataaat cgtttgacaa acctgaatac ttgaaaaaac 3062341 gaagttttgt caacttcctt tttttaccct tagttataaa aaactcaata tgatgattat 3062401 ctgctagatg acctttggga atatctattg aaaaaccggg atattttttt attacttctc 3062461 ctaaacttat ataatcatta tgctgtcttt ttatattctt tgcttttatt tttgtttcgc 3062521 caattttagc ataaaactta aaacctttag aattaaacag cgagctccaa aagccttcta 3062581 tgtgaatgga atcctcattt tcttctaaaa tttcaatagt taaagtttga tccgataatt 3062641 tcgaaacaat tttaccttct ctgtataaat aataatcctg ttcagtttct ctttcatata 3062701 catacctact ataattttca ccgtgcttta tttttaaagc atgatataaa tagaaatggc 3062761 tgacactttt tgtttcaatg atgacatcgt cgtcaatata cgacaatact tctcgaatca 3062821 atgttaaaaa ttcactgtat tcattttcgt ctaaaggtgt ttcactgata tccttaatca 3062881 ataatttcca cttcaaatca tgcataacca tatattgaag aaataaaggt attttctgtt 3062941 catgattttt tataatatcg attaaattct ttgagaaagt gataagtgaa tggttaaacc 3063001 aattcttatt tgctttagca gtctgcatgg cagatgatcc atcttctcta actctataat 3063061 ggtattttgc ctctttaacc agaccatact ttttcttttg cgatatgatt aaattaacta 3063121 gtttggcatc ttcacctatt ttacaatttt catcaaacct gatatttttc aaggcatctt 3063181 tttttataaa tgtagaacaa caatgagtta atatatgatg cggttctttt tctacatcca 3063241 aaattcttgt agaagaaaac ttattattta gattatgttc tccagttctt ccttctgcaa 3063301 aaaaaatagg gattgctaca atatcaattt cattcttatg ttcgtcaaag aagtttaaaa 3063361 cattttcgaa tgttccttct gaaactaaat catccggatc caaaaattga atatatctac 3063421 cttcagcata ctttaaacca taatttcgag cactgctcac tccgccattc tgtttctttg 3063481 catagacaat gttattggga tatttctgag catattcttt acaaatgatt tcacttttat 3063541 cggggctatc atcattcacc agtattaact gaatattctc aaaaccaata gtttggttaa 3063601 tgatactttc tatagcttca gtgagataca actcaacatt ataaatcggc attataacac 3063661 tgaaatcata gttaaaactt ttttcgttca taaaagatta ctcctaacat aatgtttata 3063721 tgaataagaa ttcgggtaaa taaaattaag aaacaagaga gtactaattt ttgcaaaaca 3063781 attttaattt agtaaaatgt atgaaaagca ttccttacct ttttttaaaa acccttgtaa 3063841 gcaaactttt aaaaatgttc acatggttaa gttctaaaga atcatttggt gtttttagta 3063901 caaagtcaaa tgcaaaggcc caaatcggta tttcgacaac aaaaccagca tatctaaaat 3063961 ctcttaattt atatccccat acttcaattg tttttttcag ttcttttcgt ttgcattttt 3064021 ttaatctttt aaaatatttt atatatattc tgtcattttc tttcatctca taatactggt 3064081 taataaagtg ccctgttaat tcaagtctaa gcccttttat ttttgccgaa gtaacagtac 3064141 atgaactatg cagtactctt tcttttttta tattttcaag agcttctgta ttttctttta 3064201 ataagtgaaa cataaattct ttatagtaca tcggcatatc ttgttctttt ataaattgcg 3064261 ggtcaataaa ttttaaaact ttaataaaat catcaacaaa aactctttgt tcttgttgat 3064321 ctaaaacaga cttataaaca tctctatagt tcggatataa aaacagtttt atatgatata 3064381 caattaaaaa ttgcaaataa ggcaaaacta tatcatattt gttgaatgaa tccatcaaca 3064441 aagtcatgta acattcattc aacaaatatg tgtacctttt tttgttaaac catgaacgat 3064501 caactaaaga atcctgttct ttccgttttc tataaaaata ctttccttct gcaactgctc 3064561 cgtatctttt ttctttcagt aataactggt taaaaaagat agcgtcttcc caaaacttta 3064621 tagattcatc aaaaaggacg gtactagtta gtgtatgtct tctgtaaaaa gtgccgccaa 3064681 tataaaaatg aatagcttta taatcgttga gaatatttat aactcttgtt cctttttcaa 3064741 atctattatt taatttatgt cccccttctt tttcacctgt gtaataaaca ggtaataccg 3064801 caatatttac atgttcggaa tcacaaaaaa aatcataaac actttgcagc gcattttgag 3064861 agaatgcatc gtcagaatca agaaaaccaa taaatttaga tctttcgctt acatttgata 3064921 atccacaatt tcttgcagca gaaggtccag agttttcaat tttcatgatt ttaatattat 3064981 taggatatag atttttaaag gattcacaaa tttgaggact gctgtcaaca ctaccatcat 3065041 ctattaatat cagttctata ttttccttaa atccaattga ctggttaagg acactctcta 3065101 ttgaatatct taaataattt tcagaattat atattggtat aattatagaa aacatgtttg 3065161 tacctcttta tttagaagtt aaaggatcgt ttcaattact cttttagaag ccttgcctct 3065221 tctaaattac aaaatttatt ataaaaatcc tcatagttat gatctatata aggattatgt 3065281 aacaactctt ttaccgtatc tataagttct tcacttgttt gaagcaagtt tcctggcgtt 3065341 ttttgctgaa aattaaagta aaaacctctg atacagtctc tataagccgg gagatcatac 3065401 acaaaaaata caaggttttt ttaaaaattc atattatcaa aaaagacaga agaataatcc 3065461 ataatcaata aatcactaat taaatataaa tctcgaatat ctttatttaa agaaacatcg 3065521 ttcacaaaat atttatattt ccctaattaa attgttctga aactggataa taccattctt 3065581 acaagaataa ccatagagtc tccaaggttc cctcttcatt tcctctaatc aaattaaagt 3065641 taaatttata ctggccagct ttcttaaaat tcattatccc gcaaagttgg tgcatataaa 3065701 attatttttc tttaattcct tatttgataa tgtagaattg gtaggggatt gtagctaaac 3065761 tgtttccaga atagctttca aataaaatta atttattgtt tcttggcaga aggacaaaaa 3065821 ttttaaacaa aactgaataa actctaacta gtaaacttct gcaattggtt ataataaaaa 3065881 tttcatcagt gaactcctta aagagtgaag attaatattt acgcaaacaa gaaaaaaaga 3065941 agcaactgaa tttacttcaa gcctctttta gttagtgctt ctataaacta gccatatctt 3066001 ttctgatttg ggtagttgaa atgcctgcta ttcttgtaag gtaaatggcc tcatagtatt 3066061 cctttgtaga caatcgtacg attaagtaat cccaggttct tttgctcttt ccagtagctt 3066121 catatgtcca tagtgaaata aatcaaacat tccgtacgta tcactttctt cattagataa 3066181 catcaccttc caaccttttc caacttagaa aaaacaaaaa tccttaactg attgtttatc 3066241 atttcgacat attttttacg ttccattaat aataaacaat aatagcatat gttcctataa 3066301 aagttaaggc tctttaaaaa tgtaaatcat cagcactttt tgacaatatc gttgcattga 3066361 tgtgtatttt ttacagatct gatatcttat ctatactcat tacaacaagt tttctattcc 3066421 ggaagagtca attctttttg tcgcgttttc aagtgtaatg attttctttc tgctgcgtca 3066481 tttattttgt acgccctcct catattactt catcgtcaaa acgtgaagga attgtaatac 3066541 gtagttccta aaaattttcg tggtaaaatt tagtgaagtc tttatcaggc taagggactt 3066601 tatctaaact acgaattaca tatggagata tatagatgaa aaggagggtt gatatgatat 3066661 aaacgaaaat caattagata aaggaaaaac tgaacacttc tgaaaaaagt gataagtttc 3066721 tttcactata tcctccaaaa agaacctaaa ggtcttggac atgctgtctg gttcgcgcct 3066781 aactttatcg gcgatgagcc gtttgcgttt ctgcttggag acgatattgt tcaggctgac 3066841 acaccagggt tgcgccaatt aacggatgaa tatgaaagaa cactttcttc tattatcggt 3066901 gttcagcaag tgcctgaaga tgaaacacac tgttatggca tcatcgcccc gctgacaagt 3066961 gaaggccgcc gttatcaggt gaaaaacttc attgaaaaac cgcctaaaga cacagcacct 3067021 tctaatcttg ccatcttagg ccgttacgta ttcacgcctg agattttcat gtatttagag 3067081 gagcagcagg ttggcgccgg cggagaaatt cagcttacag acgccattca aaaactgaat 3067141 gaaattcaaa gagtgtttgc ttacgatttt gaaggcaagc gttatgatgt tggtgaaaag 3067201 ctcggcttca tcacaacaac tcttgaattt gcgatgcagg ataaagagct tcgcgatcag 3067261 ctcgttccat ttatggaagg tttactaaac aaagaagaaa tctaaacaaa aaggctattg 3067321 gacattcatc caatagcctt tttttatttc aacatcaaag tcagtgtatg ctcttcatta 3067381 tcaactgcaa aaacctgatc atctgtattc acaagaaaac gcttcttgct gctgtcatac 3067441 aatacatcgc tatcacttaa ggatagtgac gccgggttga taggagaaat gttatgaaaa 3067501 ataagctctg ttgctttatc attctccagt acataactga ttttttcata atcaaaattc 3067561 agcgtttttc tgccgtcagc cttatttcct tcagtataac cattcaattt cgattgaatg 3067621 ctggtgctgc tgtctcctag gaatttcaga aagtattcat aggaagatgc tgcgttttgc 3067681 gagacataag acgtaaatgc agtggcatgc aattcagcgt gtttcatgtt agttgcaaca 3067741 gcgctctgtt tcacataata agagtgcccg tcaaacttta ttttcgctgc ttgtttgcct 3067801 tttgcagcta ccgttacttt tgtaccgaat ggcagtgtaa cgtcagcctt ctgtttcaaa 3067861 ccctgatcct tataagcagc cgctttttca tttgctataa acccttgctt attgattgca 3067921 gttaagcgtt cctctgactt gccctttgca tcgccatgat ggttcttcac ttcattttgc 3067981 ggaatagcgc caaacgaagc aattgtacga agcggggcat taaagaacat cgttcccgcc 3068041 atgaagacag tcagaataga caaaatagca atttgaatgg cattggccag tgatttcggc 3068101 tttttcttct ttttgcggaa acgggcaaac gcttcaggat cttctttctt cctctcttct 3068161 gtctgctctt ttttatatgt ctctttttct tttttcgata gcttattaaa ccagtcaata 3068221 aacgctttgt actctttcac aaccgttttt gtttcatcaa acatacgaag ctcgccatag 3068281 tgcatccaag caacacggtc acacatcttt tcaatctgac cgattgagtg gctgacaaag 3068341 aaaatcgttt ttccttgctt tttaaactca tttattctgt ctacacactt ctgataaaac 3068401 gtttggtccc ccacagaaag agcttcgtca ataattaaaa tgtcaggatc aatatgcacg 3068461 gagatcgcga aaccgagacg cgacttcatc ccgctggaat agtttttaac cggctgatta 3068521 ataaaatcgc caatctcggc aaattcaacg atgctgtcat acatatcatc aatttcttta 3068581 ttggttaacc ccatcatcaa acacttgagc cggacattgt cccggcccgt taattggtta 3068641 ttcaaaccgg cagcaatcgc aatcagcgac ggctggccgt tcatttcaat ttcaccgctg 3068701 gtcggcggaa taattttagc cagcaggtta gacatggtcg attttcctga cccgtttatt 3068761 cctacaaagc cgattgtctc cccttcatac acgtcaaagg agacattccg cacagcaaaa 3068821 aaaccattat ccttagccgg aaaaaacaat cctttaatct tgtccgattg ttttttatac 3068881 aaatgatact gctttgaaac atttcgaaac gaaactttta gtttcatcgt aaaatctcct 3068941 tacgtattaa agaaagtcaa caaacttgtc tctgaatttc atatgcagga tagaacctac 3069001 taacaataaa aggaatgtga acaaccaaaa gtacagcgtg tacttcatgt catggaaaaa 3069061 ccatgctcca tctaagaagc tgttccggaa tccttcaata atatagaata gtggattcaa 3069121 cttcagaaca ggcactaatt cggggtggct ttgaccgagt ttcgcattaa catcccaaaa 3069181 aattggcaac aagaaaaaca aaagtcttgt tacggcctgc agcaaaaatt gataatctct 3069241 aatcagcaca ctgatcgttg agttaaacaa actaaacgaa aacataaaag caatcataca 3069301 gatgaagtaa taaatatatt gtaaccaatg cacactcggg aacacaccat taactaggag 3069361 tacaatgata taaatcacca tcatgatcat ataactaaat aagttagatg caattgccac 3069421 ggacggtaga gaactaatcg ggaagttcat tttagccacc atattaatgc gcttaaatac 3069481 actatttgat ccatcaagta tagttggact gatgaaaaac catgggatta atcctgccag 3069541 catccaaata ataaaaggca cttcgcccgc tccggttgtc acaggaccgc cctttctaat 3069601 ccccatacca aatacgaacc agtaggccag catttggata agcggattta agaactgcca 3069661 taagacacct aaataattca tttgatattt agacttggtt tcataagccg ccaatcttaa 3069721 aattaaagga aatgacgtta tttgctctct gagtatacgc aacaaatcat tcatttttta 3069781 tcttccttag acttaattgt ttttgggaat ctttctgttt aaaatttgaa agcaccgctg 3069841 attattgtaa cagatcctgc attttttttc acttctcaac aagtatctaa aaagctgccg 3069901 aaaaatcgac agctatacat tttataaaat aacctaaatt attcagcttt aaatacagta 3069961 ttaacaacct tttcagatga acgtcctgac tctaaatagc aaaacttatc atagaaagga 3070021 ccaaaagaaa ccggaagctt ataatcaggc gatgagatct gcttgatagc ctcaatcgtt 3070081 tcttcagtag tttttaccaa aggaccagga gcttcttttt caaaatcaaa gtagaaacca 3070141 cgcaacttgt cccggtaggt ttcgatgtca gggacaaaga atagcattgg ccgttttaaa 3070201 tttgcaaaat caaagaatac tgaagaataa tcagtaatca gcaaatcaga aaccatatac 3070261 aattctcgaa tatcctcata agcagaaaaa tcatatgcaa atccttcaaa aggacctaaa 3070321 tcaaaattct cagctaccag ataatgcatt cttaagatta caatatattc atttccaagt 3070381 tcttgtctaa gttgatgcaa atctaaatcg agatcgaact tataacgccc ttttgcatag 3070441 aactgatcat ctctccatgt aggggcatat aaaataacct ttttatcacg aggaatattt 3070501 aacctactct ttatcaatga tattgtttcc tcattattat cattatgaag aaaatcattt 3070561 ctaggatatc cagattcaat cattgtcttg ttaaactgaa acgcccgtgt aaagatctca 3070621 gttgaataac catttgggga aatcaagtaa tcccaattag aagcttcctt gataaaattc 3070681 cttttatatt ttttggtgtt tgtaccaggc atatggactt cttccatatc cattgcaagt 3070741 ctttttaaag gtgtgccatg ccatgtttgt aaatatgttg tatgactagg tttcggaatc 3070801 cataatggaa gccggctgtt aacaacccaa tactcagctc ttgccatagc gaagagccat 3070861 tttaatgaga ggcgattaat gtaaggaatt cccttttcat caaaaggcgc tgaatattgt 3070921 ttatttacac tccaatacat tttatactca gggtggtttt cccgcatata ttcgtaaatc 3070981 gctctcggat tacaactgta ttgtttccca ttaaaacttt caaaaatgac tgttttcctt 3071041 ttaactggca ttctgctagc catcatgaat agagatttgt atgttttagt gattaacttg 3071101 tttctcattt ttgtgatctt ttttattttt gatactaatc tcttcttctt tcctttaata 3071161 aagtatttca tccttgtttt caggctatag tcgtttactc tgatacctag agtctgcttt 3071221 ttctttttct taaagacttc ataacgaact ggtgcgttgt ttgttttaat aatacttact 3071281 aatcctttta atttgttttt tcgatctcct aaaacaagag cagtgctgtt gaactgaata 3071341 tccgttcctt catcgtcatt gcatatatac tccataaaaa gacgataaac ataacgtttt 3071401 tcatttgaga aaggaatttc tttcaaaggc actttcactt caaaatcata cagttccgga 3071461 acaaaaccat ctgctctcat gttttccagg ccatgtgttt ttctttctag cttgattgga 3071521 aatttttcct caataggtgt ttctccaccc ttttttaaaa taaggttcaa gttttttatc 3071581 cgatattgat tttcggaact caggtacccc gcataacctg ttatgcttat ttcttcagag 3071641 ctaatctcga tttgatcaaa tctgatgatt ttggcctctc ttttcacctt aatagaaaag 3071701 ttgcctttat cagttgtata aggtaaaatc aaaagttctg tggtttgatc gacatgaaag 3071761 gcgcgctcaa ttgaatttac ttcagcagaa agacgcttca agagtggttc ctgctccgca 3071821 tcttcatatt tttttcgaaa ttcgacataa aaatcatatg tttgtcccat ttcaacaggc 3071881 ataggcaaaa catgagcatt tatctcagtt ttatactcta atgagccagt gttttgaagc 3071941 ggaaattcag attccgttcc tgaacgtctc tctttcagct ttaaaaataa ctggtaatcc 3072001 tctaaaaatt ggtgttctga atcaattgag attaacaatt caagacttcc taaattgttt 3072061 ttcaagcttt tcaaaataca tttaatcaca gtgttttcaa tcattacttt tttctgctcc 3072121 tctgtataaa agctctttcc tttttgcttc cttttattag tgtcaactac taaggacatt 3072181 aactctcttt tatttccgtg accctccaag agaaattgcc tttaactgtt gtatagggct 3072241 ctactctata gccattatta gtatctatac tgtttcctga caattttgtt tcttcactcg 3072301 aaagtcttcg cattgtttta atatggccat ttgcattgaa aacaatataa aaatcaataa 3072361 cttgggtttt attagcagct atcttttcaa tatttacatc tttttcgaga tcaattacaa 3072421 acagttgatc attttgtaag tttgttgaaa taatttcagc cttattcttt ctgtccaagc 3072481 ccactaaacg tattttttta atatcattat gatcaaaatt ctcaatgtca atttctattt 3072541 tagttttatc aaaatcctca gtataggaac taatagaagg atcttttttt ccaacctttt 3072601 tagagaactt ctctctttct attcgcacct caatcatctg attaagagca aaagcccaat 3072661 tttcaatata gttgggtctt gaatattttt cagccatttt aaaagcttgt tctgaaaatt 3072721 tttgatgagt actttcatct ttcatcaaag agataatagc ttgacccaat ttctctatat 3072781 tatactgttc aatgacatat ccatttgctc cgtcagtaac taagctcctt gctccgtaat 3072841 cataatcgta tgttacaact ggacatccat tgctcagtgc ctccatattt gatagaccga 3072901 acccttcaaa atgagaggtt gaaatggtta gccaagcttt ttgaaactct gagtcagggt 3072961 tatccgtata gcctttcaaa aagacattgt tctgcagttt ggtatcttca atttcttttt 3073021 ttattttttc gaaatcttca cccgatccga atatatcaag ttttgcttca ggaatttctt 3073081 tcacgactaa actaaatgct tttactgcat gtatcagatt tttcatagat gcaagtcttg 3073141 aaataatgac agctttgtat ttttcactcg gcacattcaa tacagcggga tcaagaggct 3073201 tatcaattgt atgcggagta aagaaaaacg tctcttgttc ccctgaaatc aatttaaaat 3073261 cttctagctg ctcctcagtt ataaaaaaga cagcatccaa attatacatc tgactaaata 3073321 cttctttata gcgaccctta atttgatatt tattgctgcc gtaatgcttg ttatgaataa 3073381 ttgctccata ataggaagaa ggtgattttt tcactttaaa gacatgtttg tcttgcggtc 3073441 tgctgtccac taaaaacaac ttaggtttat cattttgttt ttgcagatat tctatccaat 3073501 attgacgcag ttccgattca tcttttactt ttatctcacc ctcaagggag taccaaataa 3073561 tatgagataa ttgaacatct ttttcttcat tgttccatac atagagtttg tctaaatata 3073621 cttgattttg gtcattaata tattcctgca gatacatctt gtttagctgc acatcataat 3073681 gagtaacgag aactaagttt ccgttcttcg tatattcctc tctctttatg agctggtttt 3073741 tatcattcca atagtcgacg taccggatag tttctccatc tccgtagtaa actacagaca 3073801 tttcattgtt cttcttacca aacaatctca acagagtttt tgcaaatttc cccattccaa 3073861 cttgcttttt tatctggtca aggcctatcc tttcttcgta tgatcttttc ccatttgttc 3073921 taacacttaa aaaatcatcg aatagattaa taacacttgt gaatttttta tcaatcttac 3073981 cgttgctgta caattcatca atttttgaag acaactctaa atcaaaacga aacgttaaga 3074041 aaaaggtgtt ttggttacac tcttctccaa ataattttga acgcaataat aatgatttcg 3074101 tcagaccgcc ataattactt ggcagtccac cagagataaa ataataatcc atgtcaggaa 3074161 tttgttttat attagattca ctcaccgcat gtaaagacaa ttttttactc cctttcggca 3074221 tctagaatat atgatcattg aaatttatat ctacccggat actttagtca caaaaatcaa 3074281 tgtaagcatc aaaaagtact tcttatttca ataagaagta ctttaattag atattgaacc 3074341 aatgatatca ggatcctaaa ttataaacca gcaatttcct ctttgatctt tgttgtagag 3074401 atgccttctg ttcttgggag gtaaacaacc tcacactgat ctttgagaaa gtcaaattta 3074461 ccttcccagt catcccccat aacaaaaaca tcaatattat gatcaataat atcttgcttt 3074521 ttttgctccc aattcttttc aggaattact tcgtccacat atcgaatggt ttctaaaatt 3074581 aatttacggt gctcatagct gtgataagct tttttttgct tttgtaaatt gaattcatcc 3074641 gttgaaatag caacaactaa ataatcacca agctgctttg cacgctcaag caatttaatg 3074701 tgaccccaat gcagtaaatc aaaagttcca tatgtgataa cttttttcat ttaaagaaac 3074761 gctccttcct aatgttaaac actattaaaa acactactga cgttagcgat taaattctaa 3074821 aaacctgttt gtattcctta tatcgacata tttctcgtat gtcttcactg atcattaatt 3074881 atagcatacc gcctaaaaaa ggttaagtac tcatgaggag aaaaacattc caaaatatgt 3074941 aattacactc agactccatt ggcaccaagg tctgttgttc attcgttcat tcaattgtaa 3075001 aattggaaac atatttaaat ttaatgtaaa gataatgtta atcctttgtt gaagatttat 3075061 gttaaaatat aaggtagctt gattttgctt ttagaaactc tcggttttta actatataaa 3075121 tagaatctta aaggaaggag gagccagaca tgcaaacaga gactattcac aatattcctt 3075181 atgttaacag taacttaaca tcatttatcg attacctaga gaaacattat attgatcaaa 3075241 agattggtgc tgtcatttcc acagtcaacc ctgaaattgc atttgcagct attaaagatc 3075301 gggactactt tgatgtacta tcttcttcaa acttcatttt gcctgatggg atcggtgtag 3075361 tcatgatgtc acgtttgact aacaacaggc ttcagtcccg aatcgcaggt tacgatgttt 3075421 ttaaagaact tctgggcgtt gctaacaaaa agaaaaaacg catatttctg tacggtgcga 3075481 agaaagatgt tataaaaggt gttgtatcca aaatttcttc tgaataccca aacattaaaa 3075541 tcgcaggtta ttcagacggt tatgttcaag atcgcaccct agtggcaaaa caaattgcaa 3075601 gagcaaatcc tgacatggta ttcgtagctt tagggtatcc tcatcaagag aaattcattc 3075661 ataactacag acacttgttc cctaaagccg tatctatagg tctaggagga agctttgatg 3075721 tatttagcgg taatgtcaaa cgggcccctt cctggatgat acgtttaaat ttagaatggt 3075781 tctaccggtt aatcttgaat ccatggcgat ggaaaagaat gcttagcatc ccaaaatatg 3075841 ctttaacggt tttaaaagaa gaaaaaaaca aaaaaacttt ctatccaaag cctgaaaaag 3075901 atcatacaaa acagatttaa aaacaaaact ttcaaataaa tggatgataa aaatgaaaat 3075961 aagatcacta ctggcgaatt gctatttgta ttttttatca gcaatcgcct tttttctgca 3076021 atgggtgaaa cctgaaagca aagtgaccct cctgatctca ttcgaagcaa acgcaaaagc 3076081 gattcttgag gaatatgaac aaggacaata ctcttataaa cttaacatcc tgtataccca 3076141 gcaggcctct gctattgccg agagcttccc gaatgtagat gcatatttat tacaagaaaa 3076201 aaaccctatc catctcatta aagctgtata cctaatgttt aacagtaaag tgatcataac 3076261 agataattac tttctattaa caagtgtgtt aaataagcgg aagcaaacga aatgtatcca 3076321 agtatggcac gcaaatggct cactcaaaaa atttggtttg gaagacatta caaacatgca 3076381 acggacgaaa actgatatta aaaggttcca aaaagtatac agttcgtatg attatttaac 3076441 tgttggctca gaagagatgg caaatatctt caagaaatca tttggaataa aggataacca 3076501 attattaaaa ataggtgtac ctttaacaga cccttattac cgagaaaaca agaaaaaaat 3076561 ttcagatact ctaaacatac aaagaaaaaa aataatcctc tatgcaccga cgtttagaga 3076621 ttataatatg caatcaattc aattgccttt tacagaagaa caattaattc atcagttaaa 3076681 agaagaatat gttttatttg ttaagctgca tcccgccatt cagaacaata ttgatattaa 3076741 atattccagt gattatatta aagatgtttc taactatgcc ttgtttgatc tactcatggc 3076801 tgcagacata ttaatcactg actattcttc tgttcccttt gaattttcga ttttaaataa 3076861 acccattctt ttttatactt acgatttaaa actttatcaa cagaagcggg gattggttga 3076921 taattatctt tccataatac ctggaagagc ctgctatgac agtgaatcat taataaatga 3076981 aattcaaacc ccatttaatt attccaaaat aaaagttttt tccgatagat ggaataagta 3077041 ttctgatggg aattcaagcc aaaatttatt gaatttcatc gaaaatttaa taagctaaat 3077101 gatgacactt gttcaaaaca gaacaagtgt tcttttttct attgaatacc gaacgtatgt 3077161 ttgctttaat gtaattagtt gcttatggca gcaaataata atagaggtgg taaatttatg 3077221 agaaaaaaag aactgtttga tttcaccaac atcacgccaa aattatttac tgaactacgt 3077281 gtagcagaca aaaccgtact tcaatcattc aatttcgatg agaaaaacca ccaaatttat 3077341 acaacccaag tcgcaagtgg attaggaaaa gacaacaccc aaagctatcg cataactcgt 3077401 ctatctcttg aaggtttaca attagacagc atgctgttga aacatggagg tcatggtaca 3077461 aatattggaa ttgaaaaccg taatggcacc atttatattt ggtctctata cgataaacca 3077521 aacgaaacag ataaaagtga attagtttgt ttcccatata aagcaggcgc gactttagat 3077581 gaaaattcta aagaacttca gcgattctcg aatatgcctt tcgatcatag ggttacacct 3077641 gctcttgata tgaagaatag acagttggca attagacaat acgatacaaa aaataataat 3077701 aataaacagt gggtgacaat ctttaacctg gacgatgcaa tagcaaataa aaacaatcct 3077761 ctttatacta ttaacattcc tgacgaactt cattatttac aaggtttctt tttagatgac 3077821 ggttatttat attggtatac aggagataca aacagcaaaa gctatccgaa tctcataact 3077881 gtatttgatt ccgataataa aatagtgctg caaaaagaaa ttactgttgg caaagacttg 3077941 tccaccagat atgagaataa cttccgtgaa ccggaaggga tctgtatgta caccaatcct 3078001 gaaactgggg caaaatcatt aatggtggga attacaagtg gaaaagaagg aaatcgtata 3078061 agcagaattt atgcatacca ttcttatgaa aacttcatga atcatgtacc tatgcttcga 3078121 tcccctttat taaaaaccgt ggggcaccaa gatacacctc cagaaagatt tcaaccattt 3078181 attcaaacct tcattttaga gtataatgct caaaacaaaa aatggatggt tccgacttca 3078241 ggttatttac catcttacac atcaaattta gtccgaaata ttactatcaa tgcagatgga 3078301 aacttgcaag tcacattaaa tgaacgctat attagtttac tgcatcaatc gatagaagga 3078361 gatttccgct taaaacaaaa ggatatccga atgggatcct ggtattttgc cggcggagaa 3078421 aaatcaaatg tgcttgaaat aggttttatg aaagggagta caaaaatcag acccgatgat 3078481 gcagccatct caaatgcttc aagaatgagt atttttatga ttgttgcgga caagattgag 3078541 gtgtgataat caaataggct gtagctattt aatagctaca gcctatttgc aactttctaa 3078601 gttttttatc gatattccgg aacatcggcc tactttatag accagcttct ttcggggcaa 3078661 tatgcataaa gaaaagactc cagagattgg agtctttttc ttttattgca cccgtatact 3078721 tcctgcgtat ttatccttcc aatatgtgct cgtgttcata ttggtaatgg tcacgccgtt 3078781 tgataatgtg acatgaacaa cttgtccgtt tccgatatag atggagggat ttaagcttgt 3078841 tgattgaaag aacacaatgt ctcccggctt caggtccgcc ttctcaatct tagttccggc 3078901 attgtactgg cttgttgcgt atcgaggcag ggaaataccg gctgctttct ggtatacata 3078961 ttggacaaat ccagctgtat caaatcccgt ctcaggtgtt actccgccct gtttgtaagg 3079021 cacttctccg acataaagcg tcgcttcgga aacaatcgga ttttctttcg ggattgtcag 3079081 gttgtcaaat cggcgaatac ccgtcatctt cgatttccag taatcctctg acaaatagga 3079141 aatggttact ttttctgacc ggcttgcctg aatgaacctg cctgcgcccg cataaatgcc 3079201 tgcatgtgaa attcccgttt tatacgtatt gctgaaatag acgacatcac caggctttat 3079261 gttctgaggg gctaccttct cgcccactgc ccactgctgt tcggctgatc gcggtagata 3079321 aatgccgagt gcctgttgaa acacatattg cacaagcccc gagcaatcaa agccctctga 3079381 cggcgtgctt ccgccaaaca catatgggac accgatatat ttttcggcct cctgaacgac 3079441 aggaacatca gccgttgccg gatcggcagc gattcgtctc gccccgatat aagttccgct 3079501 ccaatagctg ctttttttgt aattggtgat gataacccct tttgactgtg tactgtgaac 3079561 catttggccg tctccgatat aaagggcgtc atgtgtcgga acagtgccgg tgcttccctc 3079621 tttcttgaaa aacaaaatat cacccggctt caggttttcc ggttttacag ctgttccgat 3079681 tttatactgg tcgtttacag atctcggcag atgaatatca gccttactga acacatattg 3079741 tatcaatcct gatggatcga aaccctcttt cggcgtttcc ccgccatatt tatactgata 3079801 tccaagcagg ttttttgctt cgctgacaat caattctgat gatgtatcag cttccgcaat 3079861 ctccgctttt gtcataattg gaaccaaaaa acaaatgata accgccacaa gcaaaaactt 3079921 cttccagttt gccagtgtgt tcacttttat tatctcctcc tctttttgca gttttaacat 3079981 cggtattttt ttgaatatgt taagagactt tttaatattt ttacagaatg aatatgctgg 3080041 gcaaataaaa agagagtgtc tcatcagaca ctctcttttt tgaattattt attggcgttt 3080101 accggttctt cctgctgctg gattttattc atttccatat caatcttctg tttttcctga 3080161 tctgtcagct gatcattgaa tttaaaagct gacataaaca tgaacacgat ggctacggca 3080221 acaaacggcc agatggcttt gacaaatttc atctttatca ctccgattat ttagatttta 3080281 gtttgtcact atgatcaata tcaaacgtca gttttccgtc ttctactttc caagcgaaat 3080341 tagagtcttt cgtcagttcg cgaataatgg ttttctgttt aaggctgtct tttttcacag 3080401 gcgcaggtgt cgcttcatgg atatcgatcg gtgtcacttc aaagcgtcct gttccatttt 3080461 tcttcaggtg atactgaacc agtgcactgt ctcttgttct cgtccagcct tggtcaaaga 3080521 caaagttgcc gaggctgtag aaaatgacgg ttccgttata tacttcaatc ggttctaaga 3080581 cgtgcgggtg atggccgacg atgatgtcag ctcccgcatc agacatggct cttgcaagct 3080641 ggcgctggcg gtcatttgga tcattgtcat actcttgtcc ccagtgtgac tgcacaacaa 3080701 caatgtccgc atgttttttc gcttctgaaa tcatagggat gaagatttca ggatctgcgg 3080761 gcagcacgcc cggcgtattc tttttagccg cgaaaccttt cccggacaca tcggtaaagc 3080821 caagcgtcgc aatcgttacc ccgttgactt tctggtacga aattttcttt ttcgcatcac 3080881 ttaagctgta tcccgctcca acgatatcaa gattttgctt cgcaaattct ccaagcgtat 3080941 ctttcatgcc ctgaacgccg taatccattg cgtggttgtt ggcgctgttg agaaccgtga 3081001 aattcatatc cttcaagact ttcactgatt ccttattcgt ctgcagatga atctctttat 3081061 ctgcttgttt ataattcttt tgataggtta ccgggttttc aaagtttcct gctacataat 3081121 ccgaggctct aaagatcggt tcaacatatt gaaaaatact gtctgcccct ttttgctccg 3081181 ttactttttc aacatagcgt cccatcataa tatcgcctac aaatgaggct gagagtacgt 3081241 cgtcagaata cgttttgacc ttcggcgttt ccgcttttcc cgcccacatg aaagcgaaca 3081301 taaggacaaa aacgatcgga atggcaataa atacgtgctt attggttttc tttttttgct 3081361 gttttgtcag ctttagcagc ttttcatgaa agctcagttc ttttttcatc gtttgacaca 3081421 ccttacatta aattaagtag taaacaaaca tgatagcaaa ggtcgctccg ctcaatagca 3081481 gcgtgcttcc gaacgtaatg gttaaacctt gtttctgaat ggtattggca attaaacctg 3081541 gcacgatgat gccgattcct cgaaattctg cgatttcaaa tggtacaatc gggtatagaa 3081601 aatcaaacgc gatttttagg acgatccctg ttatcagcat ggcagcgaat tttctgcgtc 3081661 cgtacaaaat cataaatttg gataaaccgt atttcacaat gacatacgtg agcaagctca 3081721 ctagcaaaac aagtaaaata aagaccggct gattaaacac aagtcctaaa tatcccggta 3081781 caacaagtcc tgccggcacg atccctgttt tttccgcaaa aattaaactg agtagtacac 3081841 ctaaaattag tgcgatgtat aaatctgatc cgaacatgtc tgcatttccc cctagcttac 3081901 gagctgcttt accttgtatt cgtggatttt ttcaattaaa ggctctgcgg caccatgaat 3081961 attgccgacg ccatatatga cacggttgtg cattcttttc tttaacaatt ccataatttc 3082021 atctgttgac ttatactcta gatcatgcag tttgtctgca ggaattttgc cttcttcgta 3082081 ggcttttacg atcggttctg ttgtttcacc gattaagatc agttcacttg cttcaatata 3082141 aggcaatacg tcatttgcga attgctgtgt ccgatcgaca cggtctgcgc ggcagttcat 3082201 gatgatgatc ggatcatcgg tcgggtaacc gatttctttt acacgtttcc atatattcaa 3082261 agtagaagaa gcgtcgtttg cggcaaaccc attaacaaag tgcccaggct cgctcggact 3082321 gatcagcgga agaattctca ttgctcccgg atctggcggc gcattcagca ttcccttaaa 3082381 tgctgtttct tcgtcaatgc cgagtgcttg agccacaccc agcgccagag aagcgttatc 3082441 agggaatacc atgtattcaa atttacgtaa atactcatct gtaatttttg agttatcagc 3082501 aatgatgact tttgtgtttc gttcttttgc tttttgttta aagaactcgg tatattcact 3082561 atctgtaatg acaagatggc cattataagg aattgtagca gtaaacgctt ctgcaatttc 3082621 atcaagcgtc ggccccatga catccatatg gtcttccaaa acattcacaa tgacgccgat 3082681 attggcctgc agaagttctt cctgaaagat gatttgataa tctgggttaa cagccatgca 3082741 ttcactgaca atcgcgttag cccctctttc tactgtttct ctcatgactt ctttttgctc 3082801 tccgatattc ggcccctgag gtttccgttt aatcggcttt tcctccggtg tgtcccagta 3082861 aatcattctt gcatctgttc ctgttgtttt tccaacagtc ttgtaaccgg cttctattaa 3082921 tattccggtt gtcagccttg tcacagtcga ttttccgcgg atgccgttaa tattcacccg 3082981 aacagggagg gcatcaatgt ttttctgatg tcgtcgtttt tctaatattc cgatgaccag 3083041 tatgacagca caggctataa tgagtaacca cattgctttt cgacatctcc ttctatattg 3083101 ttgtaaattc attcatcagt atatagaatc actatgaatt ctcaatcggc attatgtaac 3083161 ataatcttcc ctaatcgact aagccaaact tctcttttga aagagatttt atacctacaa 3083221 actgttttct atttttggaa aacagcagga cttatacctt atcacttttt aaaaaaatca 3083281 aagagaatgc gctttcattt ttctcctgat atccttctgg acgtatagtc acaccctgct 3083341 gtttgtattt aatatgcatt tcaaatcaat ctttttttca gcctttgtta tcaagcattt 3083401 cctgctatca tgcgtgtttc cggttcttat gaacacaaaa taattttatc ctgtttctta 3083461 aggacaaggt cataatgtca tcctttctgc atggaataag caatatgagg cccattccaa 3083521 aatgactaag gaggttcgag atgaaaacgc taaacatacg agtccgaatt ctctaacata 3083581 attaaacatt ttctgggatg atagtctttt ctgtttctcc ccatttacag gtctaaacgc 3083641 atgactttga aacaatttta ataaaactta atatttgttc aagaaatctt catccatatt 3083701 tgtgaagact ttgtcaaaaa aagagtgaaa accttaaatt tttcaattat atatacaatt 3083761 tacaattaga tttcttttga tatttttatt gctaacttcg gattgttcat gataatctat 3083821 ctatgtaaac ggttacataa acaaggagga gctgttttgg ctacaattaa agatgtcgcc 3083881 ggagcggcgg gcgtttcagt tgcgacggtt tcccgcaacc tgaatgataa cggctatgta 3083941 cacgaagaaa cgcgaacgcg tgtcatagcg gcgatggcga agctgaacta ttacccgaat 3084001 gaagtcgcca gatctctata taaaagagaa tcccgactga tcggactttt gctcccggat 3084061 atcacaaacc ctttcttccc ccagcttgcc cgcggtgcgg aggatgaatt gaaccgggaa 3084121 ggctatcgcc ttattttcgg caacagtgac gaggaattga aaaaagaact tgaatacctt 3084181 caaaccttta agcaaaatca tgtcgcaggc attattgccg caacgaatta cccggatctc 3084241 gaggaataca gcggcatgaa ttatccagtt gtttttctgg acagaacgct tgaaggggct 3084301 ccttctgtgt ccagtgacgg ctatacagga gtaaagttag ccgcccaggc tatcattcac 3084361 ggaaaaagcc agcgcattac gctcttgaga ggacccgctc acctgccgac cgctcaagac 3084421 cgatttaacg gcgctttgga aatcttaaag caggctgaag ttgattttca ggtcattgag 3084481 acagcttcat tttcaattaa agatgcacaa tcgatggcga aggagctgtt tgcctcttat 3084541 ccagcgacag atggtgtgat cgcgagtaat gatattcaag ccgctgccgt tttacatgaa 3084601 gcattgcggc gcggaaaaaa cgtgccggag gacattcaaa ttatcggcta tgatgacatt 3084661 ccgcaaagcg gacttctgtt cccgccactt tctacaatta aacagcccgc atatgatatg 3084721 gggaaagaag ctgccaaact gcttttgggt atcattaaaa aacagccgct ggcagaaacg 3084781 gcaattcaaa tgcctgtcac ctatatagga agaaagacga caagaaagga agattaagat 3084841 gcgtaatatt tgtgtgattg gtagctgttc tatggattta gtggtcacct cggacaaacg 3084901 cccaaaagcc ggtgaaacgg ttcttggcac gtcatttcag actgtgccgg gcggcaaagg 3084961 agcaaatcag gccgttgccg cagccagact tggggcgcaa gtgtttatgg tcggcaaagt 3085021 tggagacgat cattatggaa cagctatttt gaataatctc aaagctaacg gcgttcgcac 3085081 tgattatatg gaaccggtta cacatacgga aagcggaacc gctcatattg tgcttgctga 3085141 aggcgacaac agcattgtcg ttgtcaaagg cgcgaacgat gacatcaccc cagcgtatgc 3085201 gttaaacgcg ctcgaacaga ttgaaaaggt cgatatggtg ctgattcagc aggaaatccc 3085261 agaagaaacg gttgatgagg tgtgcaaata ctgccattct cacgatatcc cgatcatact 3085321 aaacccagca ccggcccgcc cgctcaagca ggaaacaatt gatcacgcta cctatctgac 3085381 gccgaatgaa cacgaggctt cgattttatt ccctgagctt accatttccg aagctctggc 3085441 gctttatccg gcaaagctct ttattacgga aggaaaacaa ggcgtccgct attcggctgg 3085501 cagcaaagag gtgctcatcc cgtccttccc tgtagaaccc gttgatacaa ccggagccgg 3085561 tgatacgttt aacgcagcat ttgccgtggc cctggctgag ggaaaagaca ttgaagccgc 3085621 attgcggttt gccaatcgtg ccgcttccct ttctgtctgc tccttcggtg cccaaggcgg 3085681 aatgccgaca agaaatgaag tagaggagct gctgtcatga aaaaacacgg tatactgaac 3085741 agccatcttg ccaagatttt agccgacctt ggccacactg ataaaattgt catcgcggat 3085801 gccggactgc cggttcctga cggcgttttg aaaattgatc tttcactgaa gccgggcctt 3085861 ccggctttcc aagatacagc ggcagtactg gctgaggaaa tggcggtcga aaaagtcatt 3085921 gctgcagctg aaataaaagc atccaatcag gagaatgcga aatttctaga aaatcttttc 3085981 tctgaacaag agattgaata cctttctcac gaggagttta agctgctgac aaaagatgca 3086041 aaggcagtca taagaacagg agaattcaca ccatatgcca actgcatcct gcaggcaggt 3086101 gtacttttct agaaaggaag atgaaacatg cagattgaaa tgaaagacat tcataaaaca 3086161 ttcggaaaaa atcaggtgct gtcaggcgtt tcctttcagc tcatgcctgg cgaggttcac 3086221 gcattaatgg gagaaaacgg cgccggcaag tccacgctta tgaacatttt gacaggcctg 3086281 cacaaagcag ataaaggtca aatcagcata aacggaaacg aaacgtattt ttccaatccg 3086341 aaagaagcgg aacagcatgg aatagccttt atccatcagg aattgaatat ctggccggaa 3086401 atgaccgttc ttgagaatct atttatcggt aaagagatat cctccaagct gggcgtttta 3086461 caaacaagaa aaatgaaagc gctagcaaaa gagcaatttg acaaactttc cgtctctctt 3086521 tctcttgatc aagaagccgg cgaatgttcc gtcggacagc agcaaatgat cgaaattgca 3086581 aaagcgctta tgacaaatgc cgaggtaatc attatggatg aaccgaccgc agcgttgact 3086641 gaacgtgaaa tcagcaagct ctttgaggtc attacagcgt taaaaaagaa cggcgtctcc 3086701 attgtctata tttcgcatcg catggaagaa atttttgcga tttgcgacag aattaccatc 3086761 atgcgtgacg gaaaaacggt agatacaaca aacatctcag aaactgattt tgatgaagtc 3086821 gtcaaaaaaa tggtcggacg ggagctgact gaacgatatc caaaacgcac tccttctctc 3086881 ggtgacaaag tattcgaggt gaaaaatgct tccgtaaaag ggagttttga ggacgtcagc 3086941 ttttatgtgc gttccggtga gatcgtcggt gtttcaggat taatgggagc cggccggaca 3087001 gaaatgatga gagcgctgtt cggcgttgac aggctggaca cgggtgagat atggatcgct 3087061 gggaaaaaaa cggctattaa gaacccgcag gaagccgtga aaaaaggtct cggctttatt 3087121 acagagaatc gcaaggatga agggctcctg ctcgacacct cgatccgcga aaatattgcc 3087181 ctgcccaatc tgtccagctt ctcaccaaag ggtctcattg atcataagcg ggaggctgaa 3087241 tttgtcgatc tgttaatcaa gcgcctcact atcaaaacag catcaccgga aacgcacgca 3087301 cgccatttat caggaggaaa ccagcaaaaa gtggtgatag ccaagtggat cggcatcgga 3087361 ccgaaagtgc ttatcttgga tgagccaacc agaggtgtgg atgttggcgc caaacgagag 3087421 atttatacgc tgatgaatga gctgaccgaa cgcggtgtcg ctatcatcat ggtgtcatca 3087481 gagcttcctg aaattctggg aatgagcgat cggattatcg ttgtccatga aggcagaatc 3087541 agcggcgaaa tccatgcgcg agaagcaaca caagaacgaa ttatgacact tgccacggga 3087601 gggcggtaat atgaaaacgg aacaactgca aacagaacaa aaacggattc acttcgacgg 3087661 agtcatgcaa aaactcggcc cgtttcttgg tttatttatt ctcgttatca ttgtatctat 3087721 tttaaatccc agctttcttg aaccgctgaa tattttaaac ctgcttcgcc aggtcgccat 3087781 taacggatta atcgcgttcg ggatgacctt tgttattttg acaggcggca ttgatctttc 3087841 tgttggcgct attcttgccc tgtccagtgc tttagttgcg gggatgattg tgtccggtgt 3087901 cgatccggtt ctcgcgatca tccttggctg tatcattggt gccgtactag gcatgatcaa 3087961 cggattattg attactaaag gaaaaatggc gccctttatc gccacgcttg cgaccatgac 3088021 tgtgtttcgc ggactgacgc tagtgtatac agatggaaat ccgattaccg gacttggcac 3088081 aaactacggt tttcagatgt tcggacgcgg ttacttttta ggcattcctg taccggcaat 3088141 tacgatggtt cttgcctttg tcatcctttg ggtgcttctt cataaaacac cattcggacg 3088201 ccgaacgtac gctatcggcg gcaacgaaaa agccgcgctc atttcaggca tcaaagtgac 3088261 gcgcgtgaaa gtgatgatct attctttagc cgggctttta tccgctcttg caggtgccat 3088321 attgacttcc cgcctgcatt cggcccagcc gactgcggga gaatcgtacg aacttgatgc 3088381 tatcgcggca gtcgtcttag gagggacaag tctttccggc ggccgaggac gcattgtcgg 3088441 cacgttaatc ggggtgctga tcatcggcac acttaataac ggacttaatc tgcttggcgt 3088501 ctcatcattt tatcagctgg ttgtcaaagg gattgttatc ttaattgcgg tattgttaga 3088561 ccgcaagaag tcagcttagg agggttttac atgaaaaagg ctgtatccgt cattttaacg 3088621 ttatcattat ttttgttaac cgcctgttcg cttgagcctc cccaatgggc aaagccatca 3088681 aactcgggga acaaaaagga attcaccatt ggcttgtccg tctcaacgct taataatcct 3088741 ttttttgtct cattaaaaaa gggtatcgaa aaagaagcta aaaaacgggg aatgaaagtc 3088801 atcattgttg atgcacaaaa tgattcatcg aaacagacga gtgacgtgga agatttaatt 3088861 cagcaaggtg ttgatgcatt attaatcaac ccgactgatt cttcggcgat ctcaacggca 3088921 gtagaatctg caaacgcagt cggtgtgccc gtcgtaacaa tcgatcgatc tgcggaacaa 3088981 ggaaaagttg aaaccctcgt tgcttccgat aatgtaaaag gcggtgaaat ggccgcggcg 3089041 tttattgccg acaaacttgg aaaaggagca aaggtggcag agcttgaagg cgtccccggc 3089101 gcatctgcca cacgggaacg cggctcagga ttccataaca tcgcagacca aaagctccaa 3089161 gttgtcacaa aacaatcagc tgactttgac cgcacgaaag gcctgactgt catggaaaac 3089221 ctgctgcagg gacatcctga tatccaagct gtttttgctc acaacgatga aatggcgctc 3089281 ggtgctctcg aggcaattaa cagctcgggg aaagacatat tggtgatcgg ttttgacggc 3089341 aataaagatg cgctcgcttc cattaaagac agaaagctgt cagccaccgt cgctcagcag 3089401 cctgaattaa tcggtaaatt ggctacagaa gcagcagatg atattttgca cgggaaaaaa 3089461 gtgcaaaaaa caatatccgc gcctctcaaa ctagaaacac aaaaataatt gtctgatgtt 3089521 taggaacctg cgataacgtg aatagagata tagaatgaat tatttctctt acgtgaggag 3089581 aggaacggca tgaacaaacc aacaaaacta ttttcaacat tagcacttgc ggctggaatg 3089641 actgcggcgg ctgctggcgg cgctggcacg atccatgctc aacagccaga aacaacggta 3089701 agcattgatg atttatacag ttatccgatt gattcttatt tggtatcagc agaggctcta 3089761 aatgtcagaa cgaagccttc cgcatcaagc cagaaagccg atacgctgca cttaggagat 3089821 agcctaaagc tgatttcctt ctcaaatgct gactgggcaa aggttaagta taaaaatgga 3089881 aaaacaggat ttgtatccac tcattacatt gttaaagcag cgacaacggt aaaaaccaaa 3089941 acaaaaacaa aagtgtatac atccgctgac ggaaagagca ttaagactct tccagcagac 3090001 acaagcgttt cttttttagg ctggagtaaa acgaataaag gcggttttga ttttgattgg 3090061 gtattcgttg attacggcgg tacgacaggt tatatgaaaa caaaggattt acacatgaca 3090121 aaataactga gagggattcc gcataaatgc ggaatccctt ttattatgaa ttgatttgtc 3090181 acattcccaa gatatttctc aggaaatatt gtcgtatgct gtgtcgaaac cttacatgat 3090241 catcgacatt tttgttcacg ctaaaaagcg gaggtgtaaa tatggatcaa tttgaagcag 3090301 catatgaatc gtataaagcc cggcaaacaa ctgccgatca agaaaatgtt ccatctggaa 3090361 aagaagaaat tattgcggtt agaagaaatg aggaagacaa tattatcgca gtgaaaacca 3090421 atacaggaag agagctcgac taccctactg cgctgtcaga agcaaaatca ggaaaactcg 3090481 ctcatgttga tgtcttccat aaatacgggc gtgacatttt gcgaagtgaa ccggacggca 3090541 tcaaggaaaa taacctgtct gagctgccgg atttttaaac aaatacagcc ctgccgtatg 3090601 ttggacaggg ctgtatttta aacaaaaggc tgctggatgt attcggctaa ccgttttgca 3090661 ctgtgagaaa tatcctctgc agctgcataa ttcacgccat agaacacata tggaggcaga 3090721 tacttcatgc cgatcagatt actcgtggcc tgaaatggtt tcaatagctc actgatcgag 3090781 taatgatttg ctccgcccgc ttgatatttt tccgcttcgc tccctgttga tacagccagc 3090841 atcagctcct tgccatgcaa ggcatttcct tctgaaccaa aagcccagcc ataagtcagc 3090901 acaagatcct gccatttttt caagagcggc ggagagctgt accaatatag cgggaattga 3090961 aagacaatcc gatcgtattc ctcgcacagc tgctgttcct tcgcaacatc tatcgcttca 3091021 tccgggtatt ccttataaag atcccgtact gtgatattgt catgtttact caattcctca 3091081 gcccacgcct tattaacaac tgaggtctcc atatgaggat gcactgccaa aaccaatatt 3091141 ttcatcagac cacaccttta ctgttttgat gttattttat ctaaaatcag gaaaagagcc 3091201 aaataaaaag aaagccctgc taaaaggggc tttctttttt tcttttattc agggcttcct 3091261 tcagttgttt cgatatcttt cgcaaaatca gggttatcca gattcgcatt aaagaaatcc 3091321 gctgtgttcg gaagtctgag attcatgttc attttttgag aaatcgtaac cgtgcaatcc 3091381 tcaagcacat agtcaaaaac gtgtccgcct gaattgcgtc cttcgtcaat gaagtgcagg 3091441 tgatagccag aaacggcgat tccgtttgca taagctggtg tcaagaaacc tacaatcgtt 3091501 cctctcacgt tgtcgaagtt gaaaatcggc tgtgttttga ccgcttcaac cattggcacg 3091561 taaggttttt cttgaagttc tactgttctt gtctgcacct ttttaaacaa tccgtcaatg 3091621 cgaattgcat aaaataagtt tctgcttggc agcatgctgt tgatctcttt ttcaaagtct 3091681 tcgcgtgtca ttttcgcatc aattttgtgc gtcatgtccg gtgtaaagaa cgtaaatgaa 3091741 cagaacggtg aacggtctcc attttggacc ggtgtcgcgg ttccgtctga gcgaagacgg 3091801 taaaattcgc cgtcaaaccc aatcagctct ccgtcaagct tgttaaaggt tccgataccg 3091861 aagtctccat atttcggaat ctctgacagt tcaaaatctc cgtcatatac tccgtctaat 3091921 agagaagtca ttgttgatac ttgataaatc tggctcacag gctgatcttt ttgaccacgg 3091981 ctgagcactt gaatgttgct ttctcgtttc atatttccct tcactccttt tatttagtgc 3092041 tgttcataaa acagtgtcgt gatgcgcaga gtgctagaga gctttcgttt tcatgagttc 3092101 cccgaattct ttcggaagct tgtcacttgc taaattaatg ttatcactgt agtcaaccgg 3092161 gacatcgatg atgacaggac cttcagcgtt catgccttga cgcagaacat ctgccagctg 3092221 gtctggtgat tctacgcgca agccagttgc tccgaagctt tccgcatatt tcacgatatc 3092281 gatatttccg aaatcgaccg cagatgtacg gttatatttt ttcaattgct ggaatgcaac 3092341 catgtcatat gtgctgtcgt tccatacaat gtgtacaatt ggtgctttta gtcgaactgc 3092401 tgtctctaat tccattgctg agaataagaa accgccgtca ccagagacag aaaccacttt 3092461 ttctcccggt ttcaccaatg aagcgccgat tgcccaagga agcgcaacgc cgagtgtttg 3092521 cataccgtta ctgatcatta atgttaacgg ctcgtagctg cggaaataac gtgacatcca 3092581 aatggcgtgc gaaccgatat cgcaagttac tgtaacatga tcatcgactg cattacgcaa 3092641 ctctttaacg atttcaagag ggtgcgctct gtctgatttc caatctgcag gcacctgctc 3092701 accttcatgc atatattgtt ttaaatcaga aaggattttc tgctcacgct ctgcaaattc 3092761 cactttcaca gcatcgtgtt cgatatgatt gatcgtggac ggaatgtcac cgatcaattc 3092821 aagatcaggc tggtaagcat gatcaatgtc agcgataatc tcgtctaaat ggataattgt 3092881 ccggtctcca ttgatattcc agaatttcgg atcatattca atcgggtcat agccgatcgt 3092941 cagaacaaca tctgcctgct ctagcagtaa atcgccaggc tggttgcgga acaaaccgat 3093001 acggccaaaa tattgatcct ctaaatctct agaaagggta ccggcagctt gatatgtttc 3093061 aacaaatgga agctgaacct ttttcaaaag cttgcgaacc gctttaattg cttccggtct 3093121 tccgcctttc atgccgacca aaacgacagg aagttttgct gtttggattt ttgctatggc 3093181 cgcactgatt gcatcatctg ctgcaggacc gagttttggc gctgcaacag cacgcacgtt 3093241 tttcgtattt gtgacttcat tcacaacatc ttgcggaaag ctcacaaaag cggccccagc 3093301 ctgccctgct gacgctatcc taaatgcatt tgtaacagct tccggtatat tttttacatc 3093361 ttgaacttct acactgtatt ttgtaatcgg ctggaatagc gccgcattat ccaaagattg 3093421 atgtgtccgt tttaaacgat ctgcacggat cacgtttcca gcaagcgcaa cgacagggtc 3093481 tccttcagtg ttcgctgtca gcaggcctgt tgccaagtta gaggcacccg gtcctgatgt 3093541 gactaacacg actcccggtt ttccagttaa acggccgact gcttgggcca tgaatgctgc 3093601 gttttgttcg tgccgggcaa cgataatttc aggtccttta tcttgtaaag cgtcaaatac 3093661 cgcatcaatt tttgcacctg gaatgccaaa tacatgtgtg acaccttgct ccactaagca 3093721 atcaacaaca agctccgccc ctctgttttt cacaagggat ttttgttctt ttgttgcttt 3093781 tgtcaacacc ctcactcctt attatgcatt ttaaacgtaa aattttaaat atcttgtgat 3093841 aagtttcact atacactctt tggaaattga cctccaatat cgattcgcct tatgattaat 3093901 atgtaatacg aattattaac ctatggaaag gaatgcatat tgaatggagc ttcgccatct 3093961 tcaatacttt atcgcagtag ccgaagagct tcatttcgga aaggctgccc ggcggctgaa 3094021 catgacgcag cctcctctca gccagcagat caaacagctg gaggaagaag tcggagttac 3094081 gcttctgaaa aggacaaaac gatttgtcga gcttaccgca gcaggagaaa tctttttaaa 3094141 tcattgccgc atggcattga tgcaaatcgg acaaggaatt gaactggcac agcggacggc 3094201 ccgcggcgag caaggccttc tcgtaatcgg ttttgtcgga tcagctacat atgaatttct 3094261 gccgccgatt gtccgggaat atcgtaaaaa attcccatct gtgaaaatag aactgcgtga 3094321 aatatcctcg tctaggcagc aggaggagct actaaagggc aacattgata ttggtatact 3094381 tcatcctccc ttacagcata cagctttaca tatcgaaacc gcccaaagca gcccttgtgt 3094441 tttagctttg cctaagcaac acccattgac ttctaaggaa tcaattacga ttgaggattt 3094501 aagagatgaa ccaattatta ctgttgctaa agaagcatgg cctactctat acatggattt 3094561 tattcagttc tgtgaacaag cgggcttcag acccaacatt gtccaggaag ccacagaata 3094621 tcaaatggtg attggtttag tcagtgccgg aattggtatg acatttgttc cttcctcggc 3094681 caaaaaatta tttaatttgg atgttactta tcgaaaaatg gaccaaatac agcttaatgc 3094741 agaatgggtt atcgcttacc gcaaagacaa tcataatccg cttataaagc attttattca 3094801 tatttcaaat tgtcagcaga caagaactaa agagagtgat gcaggtacat gaacaatact 3094861 tgcaatctct tttttctttt gggattctta tggaattttt attaatttaa tataatcgct 3094921 tagtacaact ttatatcagt atacgtatac atacagtaca aatagttggc aaggacatca 3094981 gtaagcgcag gacattagtt tgattttaaa aatgaaagat agagaggtga agtaaattat 3095041 tgagttcacc ggcatattca cattgctcgc ttttttcgta acaatgattt ttattttctg 3095101 gagaccaaaa ggactaaatg aagctatccc cgccacattt ggcgctttaa tggttttatt 3095161 gtgcggaagt gtgtcattgg cagacttagg ggaaatcgga acaaaagtca cgggtgcatc 3095221 ggttacaatc cttgccacta tgattatggc cattgcacta gaaagctttg gtttctttta 3095281 ttgggtggct gcaaaactgc tccaacaatc caagggttca ggcatcaagc ttttttggct 3095341 aaccaatttg ctctgctttc tcatgaccat tttccttaat aatgatggga gcattttgat 3095401 cacaactcca atccttttgc ttgtactaaa atatttaggt ttaaaaaaac atcaaaaagc 3095461 cccatattta ttaagcggtg ttttaatagc cacagcctct agcgcaccga ttggcgtaag 3095521 taatattgtt aatttaattt ctctcaaaat cattggaatg gatctatatc ttcacaccgc 3095581 catgatgttt gtccctagta tgatgggact catttttatg acttgtctac tgtttatgtt 3095641 cttttataaa cgtcttccca aaagcctgcc agatataccg ggccattttc agtctctgcg 3095701 gcatagaagg taccatcctc ttcattcgcc atcagctcct ttaccagaac gaaatcaaac 3095761 aaaaatcatg ttgtttgtgc ttgcatttgt ttttctcgtc agaatgagtc tatttgcagc 3095821 atcatatacc ggtatttctg ttcctctagt cgctgtcatc ggatctttta tcctgttgag 3095881 ctggagatgg atttatttca aaacctcccc aagagacttg ttatataaat cgccttggca 3095941 catttttata ttcgctttta ctatgtatgt cttaatttat ggtctgcata atattggatt 3096001 cacagagtta cttgtgagtt attttgaacc tgtggtttct ggaagcctcg cccatgcaac 3096061 tttcgcatca ggtatctcta cttcagtttt ttctaatctc tttaacaacc atccagcgtt 3096121 aatgatcagt acttttacct taactgaaat gaccctgaat ccttcaacaa caaaaatcat 3096181 ctacttggca aatattatcg gcagtgatat cggttcatta ttattaccta tgggaacctt 3096241 agcaacgctt atttggatgc atatattaaa acagcatgat gaaagtattt catggggcga 3096301 atatataaaa acgaccatta tcatcattcc gctgactgtt ctttttacgt taacatgttt 3096361 atatttttgg atcagttggt tatttcttta gcacagtatg aaacgaaaaa ctgccttctg 3096421 cttttcaaga gggcagtttt gtatacacta gggaagatgc attgtcttta gatgatttaa 3096481 cttccaaatg actggctctc cacttgcgtt aataagctca atgatattat tagagacacc 3096541 ctttaatagt ccgacttttt ctggcacctc tcccatatca aatatgacca attcaccaat 3096601 attttttttg atctgctcct caaaattacg cacaagagga actttggaag gcacgaccgg 3096661 caattgtgag ttgtcaagag tatacggtgt ttgttcagtt gaataagggg taaaccattt 3096721 taaatgatgc atagatataa aaagtatttt aaatacgggt gagaaaaata caatataatc 3096781 gtttaaaaca tttgtaacat atccatggat cgatcgaccc ccagttacat aaacttcaat 3096841 aaactggcct ttgaccttgt ttaatgtatt tctatatgaa aaagcttgag tttctgcctc 3096901 tatcattgga tcttccggat tgatcaaaaa tggcttctca gtactggtca ctattttcgc 3096961 cttgtttatt tgatgaagat gcaacaaggg aatataaaga taattgcagc catcaaaaat 3097021 aacaaaaata tcctgtccga tatctatgag ggtgccgaca aaccttgtat ctcctgaaat 3097081 gacaacctca acatctgtgt taaggaattg attcaaacct ttcacgattc tcctccttta 3097141 actgaaaaag ggcatcactt tatctgatgc tcctccatta tctattaaaa tttacgtttc 3097201 cagtgatagt ctatcgttct gacaatcgtt tcatagctat aatcttcctt ttgttttcct 3097261 gaacttttta ttgaacttga atagcctggt gatcttgatg attgataatc tgaagatctt 3097321 ggtgatcgtt tagatgattt tgatgattga taatctgaag attttaatga tcgtttagat 3097381 gattttgaag aactttttga acgtgacgaa cggccagatt tggatgattg ataatccgaa 3097441 gattttagtg atcgtttaga tgattttgaa gaactttttg aacgtgacga acgaccagat 3097501 ttggatgatt gatcatctga agattttagt gatcgtttag atgattttga tgagctatat 3097561 gattttgaag aaatgaacga attgctgtcc ttatcattat tgtcttcctg gttttgttca 3097621 tttttttgat cctctttttt gtacgaccct tttggaccta agctgatgct ttttatgtga 3097681 aaaggataga tgcgaagcac ctcttgattt ttcactatag tataatggcc gtcggcatta 3097741 tctacaagga taccctcaat ggcttccgga cctccacgat taattgaaac ccatttatga 3097801 gtcagactct taaaaacctc gcttaaatca tcagcttcca aaactccaac tggcgtctgc 3097861 tcttctattt tcaaatcagg ctcgtgttta cttatacttt tgatgtgatg gatattaaaa 3097921 tacactaccc catcctcatt tgtgtttaac gcagcgtaat catctcccag ccagaccaat 3097981 cttccttttt tagattccgg acccccttgg ttaaattgaa ctgattggtt tattaaatgt 3098041 ccgattaagc tatgaaaatc atcagcatcg agcatttcct cagtctcaat tgttgtggtg 3098101 ctattattgg tatcctcagt aatacttttc acatgctcca actgataata aattattttt 3098161 ttttcagctt gtaaagctat ataatctgat tttacagctg ttaattttcc ttttttagat 3098221 tccggacctc cacgatatac agtaacaatt ttatctttca ttgagtgcaa aaagttataa 3098281 tacgatattt cattatttga atgatatttc attctcctct tgctcattca aattcctcct 3098341 agtcacttat acatagatga taaacatact gcatatatac gtgtcacatt tatttgttga 3098401 actaattcaa tagcctaatt gtcgcttttt ccgcgaatac ccattttcac gcattcataa 3098461 aatacttaaa tgatctttga ggtattgtga acggttttta atatactcgc agatcacatc 3098521 cggctcacgg tcaaaacgct caatatcatt ctttttatac gggtccatga ggacaaacgg 3098581 cctaatccgt tcatacatcg ccatgatttt cggttccata tattctattg taaaaagaga 3098641 ttggagcgtt ttttctaaca ggcgcttgta ggacttgcga aactcggatt catccaatat 3098701 ccgggcggtt agtgtattaa atccttgaat tcttacataa tcggcagcca tccgctctcc 3098761 atggatatcc ctgccccaag tcgcatcata atcccaagga atcacctcaa ataatccggt 3098821 ttccccgctt ctgtataatg cgtagttgtg gacaaacccg tcatagttcg aggtgaatac 3098881 aataccagca agccagcgca aatacttatc gacatccacg tgttttgtca cttctgactt 3098941 aaactgagct ttagggaccg tattaatttt aaaaatcata tcttgtaaat aaaaatcatc 3099001 ttcctcagtc cctgttttct tttcatatcc aagctccagc gatgttttcg tttccctttc 3099061 taaatcgctc atcagagaaa agttggcatc atcatccacc gcataaaaaa tcgcgccatc 3099121 agccagcttc cttttcgcca aataatattc atctacggat tcaagttcaa gataaacccc 3099181 ttcattcttc ccattcatct ttacaaacgc aaactctgcc tttggagaca gtgtccctag 3099241 ctccgagaaa aaatccagag acaatttgtt tctcatcaag gaagggtctt tatactccgc 3099301 atttaagtga atctctcgcg cgccgcggaa tgttttcggc tgataaaagg aaatatggta 3099361 tgacttcttt ttgaagtctc tgatatgtga tccccgataa gcgatatcaa tatccagcct 3099421 tttttgattt accttcatca cagctggcac cggatcatcg tcccatatat ccttttttaa 3099481 ttcacgcaag tcttttggat gaacaaacag ctgataaagc ggtaaattgg attgattctt 3099541 catccataat cctccttaca aattttaggc ttttattttt ataagatctc agcggaacac 3099601 ttatacactt tttaaaaccg cgcgtactat gagggtagta aggatcttca tccttaacat 3099661 atttttaaaa ggaggatttc aaattgggcc actattccca ttctgacatc gaagaagcgg 3099721 tgaaatccgc aaaaaaagaa ggtttaaagg attatttata ccaagagcct catggaaaaa 3099781 aacgcagtca taaaaagtcg caccgcactc acaaaaaatc tcgcagccat aaaaaatcat 3099841 actgctctca caaaaaatct cgcagtcaca aaaaatcatt ctgttctcac aaaaaatctc 3099901 gcagccacaa aaaatcatac tgctctcaca agaaatctcg cagccacaaa aaatcgtacc 3099961 gttctcacaa aaaatctcgc agctataaaa aatcttaccg ttcttacaaa aaatctcgta 3100021 gctataaaaa atcttgccgt tcttacaaaa aatctcgcag ctacaaaaag tcttactgtt 3100081 ctcacaagaa aaaatctcgc agctataaga agtcatgccg cacacacaaa aaatcttatc 3100141 gttcccataa gaaatactac aaaaaaccgc accaccactg cgacgactac aaaagacacg 3100201 atgattatga cagcaaaaaa gaatactgga aagacggcaa ttgctgggta gtcaaaaaga 3100261 aatacaaata atctaagttt tcattgtttc aataggctgc cggcggaggt acggaagcct 3100321 atttttttat ttgccctgta ttagatatat gtcatgacat aacatatgca acccgcatca 3100381 tttggtttcc tttaaaccat ttcgttataa tcaaggtatc ctaacgataa aggcggttgt 3100441 tgctatgtac atatttcaag ctgatcagct tagtgccaaa gacacataca agctattgtc 3100501 aggtaccgtt attccccgcc ccattgcatt tgtgacaaca ctttcttcag gaggagcggt 3100561 aaatgccgcg cctttcagtt tttataacgt cgtcagctca gatcctccgc ttctcagtat 3100621 ttctgttaac aggacggaag gacgccaaaa agatacagca cgaaacgcag tggagaacgg 3100681 agaatttgtc gttcatgtca gtgatgaagc catcattgaa gatatcaatg aaacagctgc 3100741 aagcttaagg ccggatgaaa gcgagcttac acgcacctcg cttcatcctg ttgaaagcaa 3100801 agctgtttca gttcccggca ttaaggaagc ccgcgttcgc tttgagtgca aattagagcg 3100861 gcatattacc tttgacaatg atcaaggcat cactacagca gatctgctca tcggaagagt 3100921 tgtctgcttc cacctagatg aaaaggtgta tgatgcagaa aagggatata ttttaacgga 3100981 tgaattaaag cctgcctcac gattggcggg aaatcactat gccaagctgg gggaagaatt 3101041 cacactgatt cgtcccagct gaagagaagg actatttaaa tagaagaaac tagtcaaaaa 3101101 gaccttatga ttacaaaata tcgcctgtaa ataactgaaa aaatatcaaa aaaaagaaca 3101161 cccagagcaa gctcggggtg ttcttttatg aaacgttttt cctttttctt cgtataaagg 3101221 tagattagga ggaattggaa tgacaaactt ttggatttta atgctgatcg ctattaccat 3101281 cagtctcgcc tctcaatttt ttataaagaa aaaatacggt attgataaat ccggctggcg 3101341 atataagcat gtcagcaata cacacaaatg gatcgaaatc actttactta ttttgtttgt 3101401 gttttcactc tccttttttc cagttgaata tttgcttctt ttatttttta ttgtgattga 3101461 ctcaatacgt atttttatgg agtggcatta tagacctgaa gataaacagt atatgtacca 3101521 cattgtagag gtctccctta tgtttatgct tttgatttat gtttgtaccc tatagttatt 3101581 taaatcccca cagccgctcc gtctccccga ggatcggctc cgccttggag aaagccttct 3101641 tcatcaactt tgattgcagc cgcttgtccc atcagcggat catagtcacc gacaacctcc 3101701 acgagatgcc cgctgtcttt cagtttttgg attgttttgt ctgtgaatct gccctcgact 3101761 ctgagacctt cgtattcctc tccccacgtt ctgccccata cccagcgcgg ttcgctgatt 3101821 gcctgctgtg gatgcattcc gtagtccagc attcgggtaa tgatggccgt ctgggtctgc 3101881 ggctggcctt cgccgccttg tgtgccgtac agaatttttg gctttccgcc tttacagacc 3101941 atagccggca tcaacgtatg gaaggtgcgc tttctcggtt caagcgtgtt gacatgattt 3102001 tcatccagtg agaaaaacga tccgcggttt tgcagtaata tgcctgtatc accggcagtg 3102061 actgccgagc caaattcaaa gtacaggctt tgaatgaatg acactgcgtt gccatccgca 3102121 tcgattacgg ccgcatatgc cgtatcactt cccaccggcc tgctttctgc cggtattgcg 3102181 agatagccga tttcttctgc caattgtttt gcataacgtt tgtccaaaag cctttcaagc 3102241 ggaatgtctg caaacgccgg atcagtcagg acggcatccc gatctagaaa actctttttc 3102301 aatgcctcca caagcacgtg ataatactca aatgaaccgt gttcgatttg ggtgaaatca 3102361 tagttttcca aaatgttcag tgttaataaa ccggtaaatc cctgagaatt cggcggcgcc 3102421 tgatacacac tgtatcctcg ataatcactt gatacaggcg ctgcccactc accccgatgc 3102481 gctttaaaat catcgattgt catgtaactg ccgttattct gtaaatgtga gacaatccgc 3102541 tgagcgagat ctccttcata aaatgcgctt cttccttttt cagcaatcaa gttcagactg 3102601 tctgcaagct ctttttgcac aaaccgctct cccgggacag gtgctttgcc ccttctcgtg 3102661 aagatgtcag ccgtgtaagg cgtggaagcc agcagttcaa tattcttttc tgtgtgacga 3102721 cactgatcag ctgatacagg aaacccattt tgggcataat cgcgtgcggg ctccaataca 3102781 tctgcaagag acagacgccc gtactccttc aggaccgcat cccagctatc aaccattccc 3102841 ggcacggtaa tagcactgtc aattccccgc agcggaatcg cgctttttcc cttatataca 3102901 tctctcgtta cgttttttcc tgaacggccg ctgccattgt agacttttac tgcctttgtt 3102961 tcctggtgaa aggtcagcca aaaggaatcc ccgccaagtc cggtcatatg cgggtacaca 3103021 accgcaagac aagcactcac cgcaacagcg gcgtcaaacg cgttgcctcc cttatccagt 3103081 atgcggtttc cggcttgaga agcgagataa tgcggactga cgaccatttg ctttgtaccg 3103141 atgacagatt tgttcatcac aagtcccctt ttttaagaaa ttttcttcag tatagggagc 3103201 ctgatttttc acatctactg atccggcaga aaaactgacg aactttcttc ttttcgcaaa 3103261 taataagata ttttcgcatt catttcgaaa acaaatgaaa aattattatt tctatacgta 3103321 acttttatga taaaatgatt gctaaaaggc tacgaaagca ggtggagcaa ttgagtcatg 3103381 aatatcaaat ccccaacctt gtacttgatg agactgataa acaaattctc acgattttgc 3103441 atgaagaagg cagaatttct tatacggatc ttggcaaaag agtcgatttg tcacgggtcg 3103501 ccgttcaggc ccgtatcaac caattaattg aagccggtgt tattgaaaaa ttcaccgctg 3103561 tcatcaatcc cgctaaaatc ggcatccatg tttccgtgtt tttcaatgtc gaggtagaac 3103621 cgcaattttt agaagaggtc gctcttaagc ttgaggaaga gcctgcggtc accagccttt 3103681 atcacatgac aggcccgagc aagctgcata tgcatgggat ctttaccaac gatcaagaaa 3103741 tggaagaatt cttaacaaaa cggctgtatc cattgcgagg cgtcgtcagt gttgattgcc 3103801 agatgctgat caaacgatac aaaagccgta tgggaatgaa gctgtaaagg agagaaacaa 3103861 atgaaaaacc atccttatcg ggatatgacg gccgcaatgg ttcgcaccgg catattaggg 3103921 ttcggcggcg gaccttccgt gattccgctg atccgccatg aagcggtcaa taaatataaa 3103981 tggattgacg atgatgaatt cggagaaata ttagcaatcg ctaatgcgct tcccggaccg 3104041 attgccacca aaatggctgc ttatctgggc tttaagctaa aaggcacatt aggtgcaatt 3104101 gtggcgatcc tcgcccacat tctgcctaca tgtcttgcga tggtgggctt gtttgcggct 3104161 gtaaatgtgt taagccattc agcaattgtt gcaggtatga ttggtgccgt cacgccggta 3104221 attgcggtca tgctcggaat catggcgtac gagtttggcc aaaaagcgct taaaggtttc 3104281 ggctgggtta ccggcatcct gttttttatc atcgctttta tcggcctgca aactttacag 3104341 attaatcccg gcctggtcat tatcattttc ttagcttacg gggcgtttca ttttaaactg 3104401 aaagacaaaa tcacaaataa acattcaaaa gataaaggaa tgtcagcctc atgatatcga 3104461 tctatttatt tatggcgttt tttatcgcaa acctactggg atatggcggc ggacctgcgt 3104521 ctatcccgct aatgtttgaa gaagtcgtaa acagatacag ctggctctca aacgatcaat 3104581 tctcaaatat gctcgcactt gcgaacgcat tgccgggccc gatcgccacg aaaatcgctg 3104641 cgtatgtcgg ctacagcgca ggcgggtggc ccggcttcct aattgccctg atcgcaaccg 3104701 tcgtaccgtc ggcgctcgca ttgatcgtcc tgctgcgcat catccagcgc ttccgccaat 3104761 cacctgtcat caaaggcatg acgctgtccg tccagcctgt catcgcggtc atgatgctca 3104821 ttcttacctg gcaaatcggc gcagacggca tcaaagcgat cggctgggtc caatcgatcg 3104881 tgattacggg aatttcgctc cttgccatga caaaattcaa aatgcatccg gcatttttga 3104941 ttattgcggc gtttttatat gggggccttg tgatccctta tttatagaaa aaagcacctg 3105001 gacaggtgct tttttatttt agcccagaaa tgccgtttga tatgacagct gtttcttctc 3105061 ctgcgtcact cttgatcatg tgcttgactt gcagcgtggt tcctgccatt ctcacagatt 3105121 gcttcaactg ggacgaattg gtttcaactt gtatccaaac aggaggctgg accttccaaa 3105181 ataaatagag tgcaagaatc agcaagccag caatgaccga cagcaaaaac ttcatatcgc 3105241 atcgcttctt ttcagtaagc ggctcgcagc ggacagcgcc tgatgatcac gaagaatatc 3105301 gcctggacga ttgccttctc ccagcacata gcctttaaag gacattccca taaaatgaaa 3105361 aatatgttcg aattgctgaa tcagcggcag cccttttatt tttggattgt ctccgcccac 3105421 tgctattaca tatgcctgtt tcactgacat ttgctgttta aaatcaggaa atctcggatc 3105481 tctcaacgtc tgtgaccagc gatcaataaa cagctttaat gtccctgaca tgccaaacca 3105541 ataaattggg gtggcgaata taagaatatg gcactgcaat atccgttcaa tgatagaatc 3105601 gtagtcatct tgaacaggac gaaagccgcc ttgggcgtga cgcagatctt caattggttg 3105661 aattggatat ttctgcaaat aaatgtgctc cgcatcgaat ccttgaacag ccttctccgc 3105721 aagaacatcc gtatttccgc cagaccgagt tccgccgtta ataaccgcaa ttttcatgat 3105781 gcatctgctc ctttgtttac gaatgatttt cttcatcata taatggattc atcaatcaat 3105841 acagatgatt atttcgatta atccaatcgc taaaaccgat ttagaaagga agagaacaag 3105901 tggaattgaa gcagctgatc acctttatta cggcggctga acatgtaaac ttcaccctaa 3105961 ccgccaaaat gcttaattat gcacaatcaa gcgttacctc tcagatcaaa tcacttgaag 3106021 aagaaatcgg aacgccttta tttgaacggc tcggcaagcg gcttatcttg acagaagcag 3106081 gaaaaacgtt caaatcttat gcacagaaga tcattgcgtt aacagaagaa gcgaaaatgg 3106141 ccacaaatca agtaagagaa acaaccggaa ccttaaaaat cggggcgacg gaaagccagt 3106201 gcacataccg cctgccccct atcataaaag aatttaaaca ggcttttccc caagtaaagc 3106261 tcatattcaa accatatatc tccaatgaac aagcgaaaga acagctctta cagggccagc 3106321 ttgatatcac cttcatcttg gatgtaaacc ggatggaaga cgcactgcac gttgaatctt 3106381 tgattcagga tgagatcaaa atggtggctg ctaatgacca tccttttcct gcggatttac 3106441 cagtaacatt gaaggatctt caaaacgaaa ctcttctgct gacagaggac ggctgctcgt 3106501 accgcacgct ctttgagaac aatttgcatg actccggtat ctatcctaac aaattggaat 3106561 tcgtcagcat agaagccatc aaacaatgcg tgatggccgg acttgggatt ggaatcttgc 3106621 ctgaaatgac agtaaaagat gatattgcag caggccggat gaaagaactc aattggcaga 3106681 gcgattgccc cgttttcact caattagcat ggcataagga caagtggatg tctgcgccat 3106741 taaaggcttt tatcgatttg acacggaaaa cattcaaata aaacctctcc acaaggacga 3106801 caaggttttt gagaccaggg cacacacata caaaaaaaac acttgatgac ttagagcccc 3106861 aagtgttaca cgtgattttt ctgataaaac gttcgcaaaa catgcgtctc aaggtcagcc 3106921 aggcggacag ggatcggcag cctgctttct tgattgatca agctcatcgt gatctgatag 3106981 ctgctgtcta aatcaatata attaccgcaa gacaagaaaa taggcttcac gtcccgccgc 3107041 gttcgcagcg cccgtccata tacctcgccg tcaatgataa tatcggtgta tgcgcctact 3107101 tcaatttcag gcgtcacgaa atcgcagcct ttgattttga gataggtttt cgctatccca 3107161 atcgtcggct tgcccagaaa aaaagccgca tgggtggcaa cgcccatatg attgtaatgc 3107221 agatatccgt tgccatcaaa caagaagaca tccggctccg tctccagctt tttcgccgcc 3107281 tcgatgatca agggcagctc gcgaaacgca agaaaaccgg aaacatacgg cacgctgatt 3107341 ctccccatgc tgtgcacttt ttcaatgact tcttttgtat cagcgtcaat tacgataata 3107401 cagcacactc cgtatggttc tccatcctgc tcccaatagg ccaggtcgac gcctgcgcag 3107461 gtgttgatgg agtctggatg gatcgtgggg gataggttga tacgattttt aaggttaaat 3107521 tgcacttgta aaaagtcttg ttcctttttc atatcaaatt tatgcacatc aaataccttc 3107581 ataacgattg ctcactctcg acctaaatta atgtgagtct ctcttctcga ttctagtatt 3107641 tcaaaatgag gactatctgt atctatctcg tacttattta atagattgcc ttcttcatcc 3107701 caattctttt cagaaattag tatggaatgc tcatactgtt gctcactttt tttcctgcca 3107761 ttttcaaacc aaattatgct tataccgtgc aattgcccat atcggtattc tttttcactt 3107821 tttttattcc cgttttcata aaattcacat gttaaaccat gggccagacc attcttatat 3107881 ttagtaaaat agatgatttg accatttgga tataattcgt aagccagccc tgtaaacggc 3107941 tggccatttt cgtcttcagg attatctaaa atctcatcac ttaccgaaga gaaccataaa 3108001 tcctcaaagt ccactccctt ttcttttata ctcttcatat catattcatt ttccatactt 3108061 taaagcctcc ggtatataat ttgtattttg agttatatat tcacaatgtg gacatctagg 3108121 cattgggaca ccttctggca tctttttatt tattttccta gcacttacta catataccat 3108181 taaatctttt aaatccgcat caggtctttg aagtaacgct tcatttagag cattaacttc 3108241 ggcatgagaa cccgcccctg acgtctttat ataaccttct ttaagttctg taggcatatt 3108301 tacaattcta tcatgaataa gtggatgtag taccttaggt ggcttcccat ctatattgtt 3108361 tattccaaaa taataattgc ctgttttttt gtccaataca ccagctaccg cagggcctct 3108421 ttgtttttta gttagaccag aagatttaat tctactaagt tcgtttagta cttctgccct 3108481 tagatttatt cgatggtgaa gatcttcttt agacaataca ccatgcttat ttcttaaata 3108541 ttgaagccta gtttgttttt cttcagtagt cttagcaata ttgctaataa ggctttcatt 3108601 actcacttta ttgacatatg gagcattttt ttggtacaac cgatcaaagt agtgtgccaa 3108661 tcctgctcca ccaataatag taatagcttc cagcgcccct tgcttccgct tctcctcaga 3108721 cactttgttt ccgaacatat cccggcctgt gacagcttct gagaatccgt ttgacgcaac 3108781 aaggccgtat gcgcccattt ctgtcatttt gagaatgtct aaggatttgc ctgttttgta 3108841 ggcgtctaat gcgtgttcag cagcgatagc tgcttttccg gttttgtaga tggcttttcc 3108901 gcctttgaag gcccggcctg cccagccgac gactggtatg aatccggcag cggccatagc 3108961 tcctgctgtc acacgctccg cggtggagag tttttctccg gtaaccggat caacgccttc 3109021 ggttgctctt ttataatcat aatagccagt gacttctcca gtaaagttgc aaactccatc 3109081 ccatgttttt tcgtaccacg gtttgtttgc ttcttcctcg gctttttcct ggagccgtct 3109141 tgcttctgct tgctgggttt ttgcatcgat ataggttgtt ccttgatttt ctacttcaat 3109201 gacgcttttg tagacttcat tgctgtggaa ggcttttttg tcatagtaca taggggatgc 3109261 gctcttccca ttgctggtgg cctgcatgag aacagaatat ttggtgagca ctgcgttgtc 3109321 cagagattct aaattttgat attcagtggt cagggattca tcaagcttat cgacagctgt 3109381 gattgtatca cgtctgattt tttgggcatc gcccatctta tctgcatagt cgtcaagcgt 3109441 gtacatgtcg agatcaataa tatcgctgat gcctgacaaa atagaatcga tttcttcttt 3109501 atgagcggag acaatctctg aggctttcag gtctccattg ggcagctcat gatccaaaaa 3109561 agaagtttcc acatatgaat cattcagttc ttgatcttta atatctcctg aaatgccgtt 3109621 taaaaacgca atttgagcag agacaagcgt cagccagctg tctacgattt ctgcctgtcc 3109681 ctgaaaaaaa tctttaatat tgtccgcgcc atttccttta aaattatcgc ctaaatcggc 3109741 aactccctga aacgcttttt tcagcgtatt cagctgctct tcaagcgtct catattgctt 3109801 ttttctgctc ttcgcttctt cgattaaaga ttttgattca aatactttac tcatcgcact 3109861 gccctttctg ttctatttta ccgctatcgc ctcgtcctgc tctttgagtg aatctacgtt 3109921 atcctttgta tcctcgatat ttttctgtac cgcttttttg taatctccga gcatggtttt 3109981 gatgttctcc tcacgctcat ggtatttttt cgtataatcg aggctgtttt ttccgttgga 3110041 tcctgcggcg ccgattgata cgtcagcaag cgcatctttg acagaatcta atgttttgat 3110101 gactgtgtcg tacttcagct taatttctga cataaaaaaa gatcaccacc attttagttt 3110161 actaattgta tttccgactt cttccgcgaa ctcttctccc tttttaagaa gatctgctgc 3110221 accatttgct atgaacaatt ccgatgcata tttagcttta tcccattcaa gatcaaaaat 3110281 tttcccgtta atcgaagcca tatactcgtt atatttatca ttcacaatct tagatgcttc 3110341 cgatttcgcc tcttctcttc ccttgtcgaa atcatcggct tttgttcccg tccaatgctt 3110401 gcccaattcc ggtttcacaa tttctttgat ttcagtgatt gcctcttctt gcagtgtgtc 3110461 tatgtccttt tttgcttttt tcagcttttc gatcttgtct tccacgtctg aaatttttcc 3110521 gttgagcgaa cttttgatat ccgctagcat actttcataa cccatctgaa tcacctctta 3110581 atactcaaaa agtcgtatgg aggggctgat gaagatagac ttttccatac tttatttcca 3110641 tatattatat tttaaaatag ccagaaggcg gcttaaatag ggtaaatggc ttaatttagg 3110701 catataacgc tcttgaaatg taggtatttg atcttgtttt tgttcgttat acagctaata 3110761 aaagcgtttt ataaaatgaa atcacctaat gtcatagtta taaaggcact tgaaagaggc 3110821 agatgttgtt gatctgcctc tttcggcgct gagcttattg ttcatgttta tgttcttcat 3110881 ctggtcggcc atgtctgatt ttgtcatttg gcttctatta ttcccccctt ctgacccttt 3110941 ggatcaaaag cttgtattag ctgcagtccc agttgtacag aacgtttgaa aagtcttttt 3111001 tccttagatc ttcaggtgtg atgaaaaaat tggcgatgcc gacgtctccc cacattgaat 3111061 cgatatcatc gtctgaatca atttgtaaca gcatgatggt gtgttcttta tatgcgtatt 3111121 cccggggatc atgctgggta aaagaagcgt atccgccaat tttatggcca aatccgtttt 3111181 cagccagttc attataaatg tcttcttcat cctcgccgaa ctgaccaaag aactccattg 3111241 tttccatgcc cgtatactgc tcaaattgaa aatctgtagg cagcacccat tccgaagatt 3111301 tcacaggctc gactgccgct tctgataaaa tcggaaaatc acattcgcct gtgccaataa 3111361 atgaaaaatc agaaacaagc tcgtcatcgt tttctacgat attttcaaaa tagatcactc 3111421 tgaaattctt ttgttcacat cgatcgtcaa aattcaatcc atagacgtca tcatgaacag 3111481 aaatgtagaa ctgcaggata cctgaagaag ggtagccgtc aagctgggga atgtgcgaga 3111541 aattaatctg cgccagaagt ttcatcggct gtccattttc gtcagtcgga tatgtttcat 3111601 gcttggggaa atagggatca ccggcaattt tgctgtcata tcgtcctgtt ttcccctttc 3111661 tcacattcag tttcacgtat tctttcgctg atttctccag caagtcgcgg tacggtctca 3111721 ttttttcggg cagatgattc atcagattct ctccttttcc ggcatctcca aggttttatt 3111781 ttctggtttt cttctaatgt ttttcaaacg aatgtttaaa gaagccctac ttctgcataa 3111841 ttttccaaac aatagttaaa tagtagcaaa tgtattcagc accccgcaat agatgaaaaa 3111901 aagactggtg cgcaaccagc ctttcttttt catctattga attgcacctg acggaacaac 3111961 cgccttccgt ccgacagaat aatactccac tcctgcagcc aaagcctcat ccaatgtgta 3112021 gcagtttctg ccgtcaaata tgagcggcgt ttccatcaaa tcctgataag ccgctaacgg 3112081 gaattgttta atgtcagccc agtcggttaa aatcatgacg gcgtcagacc ctttgacagc 3112141 ttcctcgatc gtctctttat attcaacagc ttgcgggaga acatgctttg catggctaac 3112201 tgcaatggga tcgtaggctc tgatacgggc gtcgagcgca gcgagacggt ctgcaataac 3112261 aattgacggc gcttctctca tatcgtcggt attcggttta aatgacaggc ctaaaagggc 3112321 aatcgttttt cccgtcaccc caccgagcct gttcagcgct ttatcaacca gcatcgcctg 3112381 ctgattgttg ttgactttga taacggattt cagcagttca aaatcatgct cgacattgcc 3112441 ggcaatttgc acgagggcgt ttgtgtcctt tggaaaacaa gagccgccgt agcctatgcc 3112501 cgcttttaaa aactggctcc cgatccgctt atcctgtccc atcccgtatg cgactgcttc 3112561 aatatcggcg ccgacctttt cacatatatt cgaaatttcg tttataaaac tgatcttagt 3112621 ggccagaaaa gcatttgagg catatttgat catctcggcg cttctgatat ccgtttggta 3112681 aatcgggatt tgaaacggac ggaagagctc ctccagcgta tttgctgttt tctcatcggc 3112741 cgtcccgatc acgatcctgt caccatgaaa ggtatcatag atcgccgacc cctcacgcaa 3112801 aaattccgga ttggatgcga ccgaaatact gacaggctcc gctagatgtt cagtaatcag 3112861 tccattaatc aaatcgtttg tcccaacggg cactgtgctt ttcgttacca cgactgtatc 3112921 tcgtttgaca tgctttgcga tgcgtttggc cgcatctgta atttgctcca gattggcgtg 3112981 cccgtcgctt ttctgcggtg tgccgaccgc tataaaaatg atgtctgcct gtgccaagcc 3113041 tttctcatag ctcgtttcaa agttcagccg tccatcagct gtattttttc tcatcagctc 3113101 ttcaagacct ggttcaaata tgggggaaat gccctttctc atttcatcaa tcttgtgagc 3113161 gtcaatatca atgcaggtta catgatgtcc aatctcagaa agagaaacac ctgtcacaag 3113221 accgacatag cctgttccga tgactgttat attcattgtt tccctccaac agttaaattg 3113281 ctgctttgca gcttccgtaa tatcgtatga gaacatccta tcatgaatgc gaatgatctc 3113341 ccgcatagcc tgtcgggtac agcctgtaca gatttctgaa atgtgattca accatacaat 3113401 acactattat atcgctctca aaaagaaagt ggtgaaatga gaatcggctg ttaaaaaaaa 3113461 ccaaacaatt ttcttctttt gaccggctgc ggaggctgtc tgaagatggt ctgattccgc 3113521 aggagaagct ctgcattttc cgtcagcata taaggaagtt ccgagccgaa ttctttctct 3113581 agaacataaa gagcctcttg agtgtgaaaa tttctcgttt tcacattatg ggcatctgag 3113641 gctacgaaat ggatcaaatt ggcttcaacc agccggagag aaaatgcttt cagctgcttg 3113701 ccgaagatcc ccgcaagact tcctgaagta atctgagatg ctgctccttt ttccacaaga 3113761 tgatacagca aggacgggtt ttcgcgaatt tccctgttgc gttcaggatg ggcgataacc 3113821 ggaatatatc ctttcagctg caaatcataa aaaagctgct ccgcatatcg gggaacgtga 3113881 tcaaacggaa actcaatcaa gatgtatttt gtatcattca gcgaaagcag ctgacgtttg 3113941 gcaaggtctt gttccacctc gccgtagatt ctgatttcct gtcccggaag cacatgtaaa 3114001 ggaatgtctt ctttgattaa acgtttgttt aactgatctg ctgcttctct gactgcggct 3114061 ggctcgtttt tatacacacc gttgttatga tgaggtgtcg caatgatcgt ccggattccc 3114121 tgacgaacag ctgctcttgc catttctatg ctgtcggccg aatcacctgc cccgtcatcc 3114181 attgcgggaa gaatgtgaca gtgaatatcg atcatgtcct agcccccttt tttcgcaaaa 3114241 ataaataacg ggcacgatgc acgttattta tttttgcatg aaattgtcct tggttccgta 3114301 atatccgtat tcagagtgct tcgaaagctt tttgccgttc ataatcgccc caaggagctt 3114361 gcttttgcac gttgcaagcg cctctttcgc ttttgcggct tgttcttttt ctgttttccc 3114421 gcttgaaata accagaacag aaccgtctgc cacgttgcct aaaatctgtg catctgctac 3114481 ggcaagaata ggcggcgtat caaaaatgac catatcatat gccgcacacg cttcgtatgc 3114541 aagctccttc atccacttcg aggagagaag ctcggccggg tttggcggga tcgggccgct 3114601 cgtcagcacg tcaagatgtt tttcattcga tgcttgtaca gcctgctcca tagagctttt 3114661 ctttaataaa acagatgtta agccaaccgt attttcaaga aaaaaagccg tatgtactgt 3114721 tggttttcgc aaatcagcat caatcaggag cacttttttt ccctgttggg cgaatacgac 3114781 agccaggttg gcggccgttg ttgattttcc ttcccccgga caagccgatg taatcatgac 3114841 tgatttcatt tgccggtcca ctgaagcaaa ttctatattc gtgcgaatcg tccgatattg 3114901 ttcagagttc aaggatttcg gctctgtcat tgcaatgaca tttctctgca tccgcgagcc 3114961 tctgtttttt ctaagcgcca aaatgtccac tccccgtttt ttcagattgg aaaccctgta 3115021 aggtctttgc tgttttctgc tcattcgcaa tggtggaaac tgtccctaaa acaggtatgt 3115081 ccagcaagga ttcgagctgc tcttccgatt tgatcgtatt atccaaatgc tcaagcagga 3115141 aggccagtcc gatgcttccc gccaatccgg ccgcaaacgc gatggcaatg tttagtagcg 3115201 gctttggcga tacaggggac gggtgttctg aaacctcggc ttttgacaga atgctgacat 3115261 tgtcaacatt cataatggat gtgattttgt cttgaaaaac agatgctata gtattggcaa 3115321 tatgagccgc tgtttccgcg ttttcatccc tgactgatat gttgaccact tgggagtcct 3115381 gttcgctgga tacggtaatt ttgtcattca gttcttggga tgtcatcgac aggcccattt 3115441 ctttaatgac ttcatctaag atggcagggc tcttaatgat gacattgtac gtattgatta 3115501 actgaagatt ggtttggaca tcgttaaatt ggacttcttt tcgttcattt ttcgattggt 3115561 tgaccagaat ctgagttgaa ttttcataga tgggtgtaag tgcgaagaaa ctaatgagtc 3115621 cgccggcagc agtggcagcc gcggttacaa tcataatcaa aagtatgcgt tttgttaacg 3115681 ttgataatat ctcttttaag cttgtagatt ctcccatgat acctccaaat ctcttataac 3115741 atccttttcc atctacgatt atacaacgtt gaaaccgcat ttctccagct tttcacgtga 3115801 cataattcga cattttttta caatgcgtta tgttagtact ttttatgtaa gcgctatatt 3115861 tactgtgttg acagtgctgt ctcattttct cttattcggg cagtcacgtt ctctcgcata 3115921 aaaaaatccc gctaaaggcg tgcgggattt ttatgttgca tatccatttt taatatgaga 3115981 aatcaaattt tcaagcattt ccttcgtcgt catctcagat gactgctcac caatttcatg 3116041 tgcatgcatc aaaattttca gaaattcttc ttgattcaat ttcttttcac tcatcttttt 3116101 tttcctttca gcttccatta agttgaaaac acgattatta tatgatgctg gttatcaatt 3116161 tgcaatctct aatacatcat tcgacacatc ctatttttta tgtccttttt taggaaaaac 3116221 tttttaaggc cgatgtgttg cgatataata gagaaattgg atctttttat tacgtgactc 3116281 ggttaggagc gataatcatg cttcagaata tgatttccaa agacgatgtg ctggcatctg 3116341 ctgaacagtt aaaagaactt cttccttaca atgaggaaaa tgttcagctg atcaaaaaag 3116401 cccttatttt atatcggcag gattcagtct atcgtttaca agcagtgagt ccgacggaag 3116461 ttacggctta cgtgcaggat gttgtgcctg tgcgggtcac attgaacttg tttgtcatag 3116521 tcaaaagcgg ctgttcatgt ccgtccggaa gaatctgccg ccatatgctg gctgtgtttt 3116581 tatatgtata tgcaatgttc gagcgagtgg gtacttttac agagtattgg ctggagaggg 3116641 aaaagcttga ggaaagcaaa gagctcgtcc gccgccagtt tcaggaaaag gtgctgccta 3116701 atgaagaatc actttcaagc tggcttgctt tttttgattc agagttttct ctctggcagg 3116761 cacgtacgcc agaaggcagc caaaacatgc agggcctcta ttacggctac ctgtccgcat 3116821 taaaaaaaca tgcgccgaac aagccggagc tgaaaagcct gtatcagatt cattccgcga 3116881 ttgcggtttg gcttcgcatg ttcacattga ttgaagcggg caagctaaac cccgaacaag 3116941 atttttattc cctcaatccg tacgttgaac agctgatgga tacaatctac agctctattg 3117001 ataaattaaa aacgtacgcg ctgtcttttg cgcttgatcc gtttttggat aaaacaccgg 3117061 atgttatccg gcatttgctg ttgaaagaag aaattttcca atatgaacgc atccgcgtct 3117121 tcggtgaaat ttggagtgcg ctgctgtcgc ggccaaaatg ggtggcacgc gaacaggaga 3117181 tattgaaaaa agaagcagga cggcgttttt ctcccgaatt gcaattcggg cgcctgcatt 3117241 tggaattcct gcaaaaaaat gatgacgtta tttttgagga agcggatcaa ttcccgccgg 3117301 aagcgctccc ttatacattc caatggctga gtgaaatgac tgccaagaag gactggaaac 3117361 ggcttaaaac atggtaccag caaattgaac caattgcgat gggttatacg aagctggata 3117421 agccgtttaa agagattcgc gatgtgatcg gcgagctgtt ccttctgttg aatgcctatg 3117481 tgcagcaaac caatgatcaa gcgctgtttg agcgctttgc cgcgggctgt ctgccgtata 3117541 cgttcacaga atacagccat catttatatg aaaaaaaacg ctatgccgag tggattgaaa 3117601 ttcatagcct tgtcggcttt tccatcaatg aaatggataa aatgatgctc aaggaaattg 3117661 cagcgagcga ccctgaggcg cttataccgg cttaccatag agaagtggct tttttcattg 3117721 atcagaagaa ccgtagctcg tacaaggaag ccgcccggta tttgaaaaaa ttgcgcaccc 3117781 tgtacaaaaa agcgaaaaag cagaaggtgt gggagcggta tattcagctg ctgagctcgc 3117841 attacaagcg cctgcgtgcg cttcaagaag aactgcagaa aggaaagttg attgatggcg 3117901 agtcttaaag aaattctcat ccacgtcgaa caaatggaag atgggtcatt tacgctctca 3117961 gcctttgatg agaatgagca gcctcttccc tacagccata tgaaaaagca tttgttccaa 3118021 tggcatgaat cctcatttta cggaaccttt ctagaggatg tcagcttcat cgggacgact 3118081 gctgtccttc tatctccatg gatgactgta gagcttctcg gcaaaaactc gttcaactca 3118141 ttcagctccg tgcagcttac agaagaaacg gagccgctga tcgaggcggc atcgaccatc 3118201 tatgaattta tcgcggacgg cgattttatg cctgactatg acgcatggac aaacggtgtt 3118261 tttcgctgga aggaccgcga taatatactg gaaggcttta ctgcggaatg gttttccgct 3118321 gccgtacagg attacatcca gtacgacgat gacctgcggg agaaatggga acatatcaag 3118381 gaaaaatcgc ctgcggttac gacattccgt ggccattttc ttgatgaaga ggattttctg 3118441 gaaggcattg gctggattga cgatcaatct ccatttactg tcggcttgcg cttaaatgaa 3118501 ccggactttg acggagacga atggaagatc gagatgtttt tacgcgataa aaagagcggt 3118561 gctgtagaat tctttgacgg actgaagagc ctcaaaaaat cgtggcaggc gtacagcgat 3118621 aaaatcgcgc gtgagcagga ccgctttcac agaacggttc cgtggctgtc gtttgattcc 3118681 gggacaacgc tgatctcgga ggaagaagcc tggatcttcc tgtcagaagc aagtgagacg 3118741 cttgtcgata tgggggtaga aatcctcctg ccgtcctggt ggcagattgt cagagacagc 3118801 aacatgatgc tgaaagcaaa ggtgtcttcc tccccgcgcg gcgagtcatt tgtcggcatg 3118861 aatgcactgc ttgatttcaa ctggcggttt gcgacaaatg gaattgaact gactgaggct 3118921 gaatttaatg agcttgtcgc cagcaacagg cgccttgtta atatccgcgg gcaatgggtt 3118981 aaaatcgatc cgcagtttat caaacagatg aaacgcctga tggaaaaagc agaatcagag 3119041 ggactccaca tgtctgatat tctggcgcgg gagctaatgg atcagcagga tggcggactt 3119101 gaggattcgg acctgattga tacatctgct tttgccggca ttcagtttga tctgtctaaa 3119161 cagctcaggt cactgattcg aaagctcact gccgcggaaa acctgccgga gcacaaagtc 3119221 agtccttctt tcaaaggaac gctccgccct tatcagaaat acggcatgaa ctggctgctg 3119281 tttctgcggg aaagcggttt tggcgcctgt ctggctgacg atatggggct tgggaaaacg 3119341 attcaaatga tcgcctattt ccttcacgtg aaggaaagcg gccgacaaaa aacgcctcat 3119401 ttgattattg cgccgacatc cgtacttggc aactggcagc gggagcttca aacctttgcc 3119461 cctgatctgt ctgtcgcgct ccattatggg ccgcgccggc caaagggtga tgatttcgcc 3119521 gcgcattatg aaaacgcaga cgtggtgctc acttcatacg gtctgtcaca tgccgatact 3119581 gaagagcttt cttctgtgac atggaacacg atctgccttg atgaagcgca aaatattaaa 3119641 aacgcgcata cgaagcaatc acgcgcaatc aggaagctga aggggcttca ccatatcgcg 3119701 ctgagcggca cgccgatgga aaaccgactg actgagctgt ggtctatttt tgacttcatg 3119761 aataaaggct acctcggcag tttgaccggc ttccataaac gctatgtgct gccgatcgaa 3119821 aaagaccggg acgaaaagag aatcggacag cttcagcaat taatccggcc attccttctc 3119881 cgccggacga aacgggatga agaggtcgcg cttaatcttc ctgagaagct ggaagaaaaa 3119941 gaatttatcc ctctgtcagc cgagcaggca tccctttatg agcagctcgt caaagacact 3120001 tttgaccata tgacatccct gaccggcatg cagcgaaaag cgctgatcct cagcatgctt 3120061 ggacggctca agcaaatatg cgatcatccc gcgctttatt taaaggaaga gcaaaccgag 3120121 ctgctggccg gcagatcagt caagctcgaa aaattgctgg aactgatgac agcgatccgc 3120181 gcccaaaacg aaagctgcct gattttcacg caatacattc agatggggaa catgatgaag 3120241 cggctgcttg aaaaaacgtt cggggaacct gtgcaatttt taaatgggag tctctccaag 3120301 caagagcggg atacactcgt tgagaaattt caaaggaaag aatatccgac actgattctt 3120361 tcactcaaag ctggaggcac cggacttaat ttgaccgccg ccaatcacgt catccattat 3120421 gacagatggt ggaacccggc ggttgaaaat caagcgactg accgtgcata ccgcataggc 3120481 caggagcgct ttgtccacgt tcataaaatg attacgacag gaacaatcga agaaaaaatt 3120541 gatgtcatgc ttgaatccaa gcaaaccctg aacgatcaaa ttatccaaag tgaaaactgg 3120601 attaccgagc tttccacaca ggagctcgaa gaattgttta cattaagcgc tacagcgcaa 3120661 taatcatgac taaaaaagct ggctctaaaa gagccagctt ttttccgttc atagccgtca 3120721 cgccgaattt ccaaaaaatc cgttacgccg gttatcaaca gggtgcgctt ttgtggcagc 3120781 acatatactt acaacaaatg tttcatcata tgtgcgacac cgtgttcgtc attggttaag 3120841 gtgacagcat cggctatcga tttgatgtct tcccgggcat tgcccatcgc tacacctttt 3120901 cccgcagcct ccagcatcga tttgtcattt aaactgtcac ctacagcagc agtttcctcg 3120961 agcggaatat tcagctgttt tgcaagcctc ttcagcgcct gccccttgga agctttgcgg 3121021 gaagaaagct caaagttgtg ctcagccgaa ctgacaagcg tcaaatcttc ggcatgctca 3121081 tatcttttcc agcctgcctc aagcttttct ttgaagaaag aaaagccgag aatattgtaa 3121141 aaatcgattg gctcatcggc ttcaaacagc tcttgaaagg agttaatgta agcaaagccc 3121201 gattggctgt attgcacctc ggccgcctgc ttaaggacag aaagatccgc ttccggattt 3121261 gcgcttctga atctgtcgag ctcaacatca agaagttctc tgccgttttg cggcgtataa 3121321 atcgctgaac ctgtgaatac ctcataataa tagttttccg actcaagcca tgagagaatg 3121381 tcatacgccc gtttcttatc aatcgtttcg tgatgataaa gcctgccctc gggatcgtga 3121441 atgacggcgc cgtttgcact gatgacccat gttttgatcc ccagcggttc aaagattgac 3121501 atgacgtcaa aatgagcgcg cccagttgac accaccactt caatgccgtc ccgctgcgcc 3121561 tgccgcagtg cgttttcatt ttccaagctt acctgatgct tgctgttgag taaggttcca 3121621 tctaagtcaa tcgcaattaa tttcacgttt gtcagtcctt tccttcatcc tgctctgtca 3121681 cgagaagctc aacgccgttt cggtcaagca agtcacaaaa tgcctgattc ggcagcctgt 3121741 ctgtaatcaa gaggtcgatt tcattcagct ccgcatactg ataaaaactg gtgctgccca 3121801 gcttagaatg gtctgcaagc gcaattacct gctttgcctg ctgtatcatt ttccgcttca 3121861 ccatgccatc ctcttcatgc gcaattgtaa tgccatgttc ggaaatgccg accacaccaa 3121921 tcagcgcttt atcaacatgg tagcttgaga gcttttcaat cacagaggac ccgtacagaa 3121981 agcggtgctc cttttccagc ttgcctccca gcagataaat ttcaattccc tctttatcgg 3122041 acagcacatc cgcaagatta atcgaattgg tgattacggt acaatcaacc gcattcaaat 3122101 gctttgcaca tgcctgaaca gttgtagagg cgtctaaaat cacccggtct ccatcatgaa 3122161 taagcgatgc tgcaagcctg ccgatcttat ttttttcctc agacactgtt ttcaggcggc 3122221 cggaatagct ttgaattttc tgatgcacag tcggtaaaat ggcgccgcct cttgtgcgga 3122281 tgatggcatt ctgttcctca agtttcacaa gatctcgtcg cgctgtatcc cttgacactt 3122341 gcaggagcgt acagatctgc tccgttgtaa ttcggttatg ctgttttaaa aaatccaaaa 3122401 tcgctactaa tctttcttct tggtacacgc cctcattcct tttctcagca atcatttata 3122461 agtaattata agtttttatt tgattttatt caacattaat aagtgatttt aagtaaaaat 3122521 gcgtcgagag aaccaatttt tcctaagtag gcaaaaagaa agaaccagtc tggtcgactg 3122581 gtcaattttg aggggatgat gcgaagatcc ggataatagt gaatggatag ataacgggag 3122641 gagcaggggt gtcaatcagc agctttttcc cggggtttag ggtccataaa acgaacagtg 3122701 tcagccaaca cttctgttac atacacgtta acgccttcct cgttttcata gcttcttgtc 3122761 tgaatccgtc cgcttacgcc gacgagagaa cctttttggc aatacaacgc cgtgttttca 3122821 gctgtttttc tccaaagtgt gcaattgacg taatcagctt cgatttcacc tgaagcattc 3122881 ttgaagctgc ggttcaccgc gagcgtaaca tgtgcaactg ccgcaccggc ggaagtgtag 3122941 cgaagatcag gatcttttgt aagacgtccg acaagcatga cctgattgaa catgcgattc 3123001 ctcctctcct tgcggttgta tgtattgtaa atgatgcaac aagaaaagaa aaacgcttaa 3123061 aaatggcttt cagcctctgt ttttatcttt cgttttcatt tttccttcag ctaaaaacat 3123121 cttttgcttt tttcctttga agaaatatgt actttttaaa aaacggaaaa agatttgctt 3123181 tgtcagccag ttttgcgtat tcatgcgcac ataggaagag ccatcccacg caaaccactg 3123241 aaagctcaat tttttttccg gcattgacag cttgatttta tactgctcca tgccatcttg 3123301 tgtttcgtat aaaaaactta ttcttccttt tttgttcaga tgaacctcaa acacttcttt 3123361 acggcttaac atatatgtta cttccttttg aatcaaatga ctttcagaag gaacgccgtc 3123421 aatataaatt tcttttaaac gaaattgatt cataccacat ctctccgtaa tccatagtca 3123481 gttacagtat aatgaaaaaa tagaaattat taaatgtttc gctcatacaa aattctttag 3123541 ccccaacatt gcaggatttt ttcctcgaaa acgtttatgt tataatggaa ggcaagaaaa 3123601 ctttggaagt aatcggggtg agaagaaatg aaaaccttta aactggttga cctgaatgtg 3123661 gaacgagtgg acaaggaaga acaatcaatt gaacagtttc cccttattga cggactgatt 3123721 ataaataaag aagacggtga aaatcactgg ctgattgagg cgcttgtaca gaaagaacat 3123781 ctgtcttttt ttgaacagct tcaaaacagc caatctgaag ccaaagtatt tgtaacgatc 3123841 acgaaaaaaa gcaatcgccc cgcccagctg acagcagcag tgaaaaatat cgtcaagctg 3123901 gaagaaagca ttcaggtttt actctacgga caaatggtca caagaaaaca gcagggcact 3123961 gaaaccattc tcgagtccct tgtaaaagag ggctatacag gaacaaaact cattgaggca 3124021 tttaagcaaa aattataaat atgagggggc atgttcccca aaacagactc agaaccgaag 3124081 agcatcacaa tagacattta gaatagatat gttctgcatg aaaaaagctg ccgttttgaa 3124141 cggcagcttt tctcttcgtg ctttcactct tgcatattta atttgtatgg ccaaaagaat 3124201 caaccaattc ccctttcaca acgaggcgcc cttcggtttt gaccgccttg tcacatgtga 3124261 ttaacgtaat ctcctttttg tttgtctcct caactacatc tgcatccatt tccgatatga 3124321 tgtctttcga tgttacagaa tagatataat cctttttaaa atccgtgatg acaatttggg 3124381 cacctgtttt tatgttttcc agaggtccga acagaagatt cttttgcttc aaatgatggc 3124441 ccgccaacgg ataatttccc tcacccattt tttgatcccg gcgcattgtt gccgccccta 3124501 tcaaaagatt ttcattggtt gtgcctttta cgatcggaag ctccagatcg acacttttaa 3124561 ttgttatccg ccgccttgat tgtgaagtaa aaataagtat atttcacgtg ctttcgacgt 3124621 tctccacttg actggaatgc tttaatggcg atcccggcat ctgtagcttc aggctttcct 3124681 tcagaggaat cagaaatctc aaactctatt ttctcagtgt tcagcacata accggctggc 3124741 gctttcgttt caacaaaagc gtattgtccc ggtgcaaggc ctgaagctgt gacttgatga 3124801 tgccggatat gactggtttc gaagtctgta tgaaaattcg cgaacgattc agcatggttg 3124861 atcttccggt tctgatcatt acagctgcca ttatcggcca tgacaaatac aaggcttttc 3124921 atgccggagc gaatgacatt ttgcaaaaac cctatcatta ctctgaattt atggcgcgta 3124981 ttcaaaacct gataatgatg aaacatacag caaatcaagc cacaagaatg gaaatggcgt 3125041 ttctccagtc gcaaatcaag cctcattttc tttataatgt attaaacacg attatttctc 3125101 tcactcattt ggatattgaa aaggcccggg aggtaacaga ggaatttacc aactatttaa 3125161 gaatgagttt tgactttcaa aatacatcag ccatcagttc cttcagacat gagctttcga 3125221 ttatcaattc ctatctttct atagaaaaga cgcgattcag taatcggctt gaggttcttt 3125281 tcgatataga tgaagacatt gactttatcc ttccgccttt aatgattcag cccttggtgg 3125341 aaaatgccgt tcttcacggt gtcagcaaga aaagaggcgg aggatggatc aaactgacag 3125401 ctaaaaaaca aagcaaaaat gagtatcaca tcaaagtaga ggataacggt cccgggataa 3125461 ctccggaaaa acaaatagat ctcttatcaa cggattttga tcgcagcgtc ggattgaaaa 3125521 atatcaatca gcggctgaaa catttttgcg gaagcgagtt gatgatcagc agcactccgg 3125581 atgcaggcac ctctgtctca atgctcattc atctcgctga aacaacagga agccctaaag 3125641 aactgaagga cacagaacga acctaaacga aaattgagat aaaaaaagac gccgtttcta 3125701 acggcatctt ttttattccg gcgactttgc ttgctgcttc agcaggtctc tgatttcttt 3125761 cagcagctcc tcctgcgcat ccaccgcttc ctccgcagcc tcttcttctg cttctttttt 3125821 gcgccttaac ccattcaaag tccgaatgac gataaaaatg gagaacgata taattaagaa 3125881 gttcacaatc gtctgtataa agctgccata tttcactaca gcatcgccaa acgtaaacga 3125941 caggcctgaa aagtcaagcc ctcccagcag caaaccgacc aaaggcataa tgatatcatt 3126001 tactagagat gtgacgatct ttccgaaagc gccgcctatc acaacaccaa tcgcaaggtc 3126061 tacgatattc ccccgcatgg caaaggcttt aaattcattc cacatacaat cacctgcttt 3126121 tctatatttg taaagaaaaa aagacaaatg tgccgctggc catctgcctt ttttcaatta 3126181 ttctccgagg gcaaaagtca gttctacttc gcaaacgact tcgccatcaa ctgtggcaac 3126241 gccttttccg cgcccgattg tgccgcgggc acgaatgatt tcaacctcaa ggtgaagctg 3126301 gtcaccaggc ttgacttgtt ttttaaagcg gcagttatca atgcctgcaa aaaaagccag 3126361 tctgccgcgg ttttcttctt taatcaacat cgcaacagct ccgacttgag cgagtgcttc 3126421 tacgattaat acgccgggca taaccgggta ctgaggaaaa tgtccgttaa agaactcttc 3126481 attagcggtt acatttttat agccttttgc ccgtttgccc tcttcaactt ccgtaatccg 3126541 atccacaagc aaaaacggat aacggtgagg aataatttct ttaatttgct gagtatcaag 3126601 cattgtcttg acatctcctt catctgcatt agtatgtata gcaatcatca aagatccaat 3126661 ctgtacattt gaaaagtata ttatgaatta atctcttttt caaccgcgct aaaatgtaac 3126721 caactgtcaa tgagagccgt caaaagttat gatatgataa ttatagattt taccaatagc 3126781 aaagaggtag gaaaatgatt tcgaagttta ttgaaaaaag aatgctaaac atgttagacg 3126841 agtggtattc cgcaatgagc aaacgcaaaa tgaatcacgt ttgcacactg aaagagaaaa 3126901 ttgatcagca ccttccaaag atcaaaaaga acacaaaact ttggatgcgt tatcaattgt 3126961 ttcaggcccg ccatcagctg ctttttgaaa accagaacgg actcgattca ttgttcgatg 3127021 gcctatatgg cctggaagac aaaatggatg atgaattgaa atattatctg tattttttct 3127081 ctgggttata tgagatggta aaaacagctc cgaaacatgc agtacatcat tttaaaaaag 3127141 ctgaacagta cctggccgcc attcacaata cgtttgaagc cgctgattta tattatcaaa 3127201 ccgccggcgc ctattacttg atgaaatcac cgccgctttc cgtccaatac gtcaaaaaag 3127261 cattacacat ctatttgcac caattcggct atatcaaaaa ggtaatcacc tgtaaacttt 3127321 tgctcgccgt gaattatatt gatcaagaac gctatgaaaa agctgaacag cttttcaaag 3127381 aaatcattaa gaaaacccag caactacatg acgaaaacct gctatgccac gcttattata 3127441 accttggctt tttaaaagcg accgagaaaa aagaccagga agcgcttctt tactttagaa 3127501 aagtattaaa gaatcaagaa tttgaaatga attcaccagt ctcatatctt cattgtgtgt 3127561 acgagtctgt cagagcgctt tttaaaacag ggaacatcac agaagctaaa gccgtccttc 3127621 aaaaaggaaa agaattatct gaaaaggtag acattcaaac catttattta aaattaaaaa 3127681 cgcttgaagc cctctacaca tcagccgaag acccttatga gcagctgctc gaatatgtgc 3127741 ttgaattaga aaaaatcgag gcgtgggtgg atttagaagt gctgttagaa gatattacgg 3127801 aatactacaa aaaaaaggac gatttcgaaa aagccgcttt ttttatcatg cgcggctgat 3127861 tgaaaaacgc ccattttctt attatctgac tgaattgatt aaaccgagca tttgatctcc 3127921 cattgtgatc gttctgctgt tcagctgata tgaacgctgg gacgtgatca aatctgtcat 3127981 ttgttctgaa atatcgacat tggacatctc aagtgagccc tgctgcatgc cgatgttttg 3128041 tctattagcg ccgttcagct cttcaaaagc tgccgcatta tcaatagaga aaaggttatt 3128101 cccttcggat ttcagctctt gagggttatt cacttggaca acgccaagat taaaccgctg 3128161 aaccgcgttt ccgtcagatg cggttaaggt gccgttctta ttaatggtga tattcttcat 3128221 tgagctgtcg atgttcactg tattgccgtt ctcatcaagt acgggatacc catttccagt 3128281 gacgagctgc agctggttgg cattcgcagc ggacggcgtt acatacagcg ccccgtccct 3128341 cgtatactgg cggtttccat ttacatttac ctgaagatac tggtatggag acgtaaatgc 3128401 gatatccaga tcgcgatcgg tcttctgaat gcttccttga tcagagacta ggcgtgaact 3128461 catcatcgct ccgacgccaa ggcgcaagcc gggcggcgtt tttcgggctt ttgccacttc 3128521 ctcgtttttt tcatcaacct gatcgaattg ctgtctgaca agctcagaaa aattcgtatc 3128581 ttttgcctta tagccggttg tgttgctgtt tgaaaggttg ctgctgattg tgtcaatctg 3128641 ctgctgcagc tggtttaagg ttgttgatgc cgttagcatt gacctgagca tagttgatgt 3128701 cccccgtttt tttcttccgt tttcttaaat ttttccaatt tcatttgctg ctttatccat 3128761 acttttatcg taagcctgaa taaccttctg attcgcctca aacgatctgt acgcttcagt 3128821 catttctgta taggcgcttg tcacatccac gtttgaaagc tctgagacgc cttgttttaa 3128881 tgaataggct acctgattat ttccggctgc gcttggcaga tcattaccgt ccgccgtgct 3128941 gtacaaatca tttccgtccc gtttgagatt gcggacatct tccgccattc tgacatcaat 3129001 ctggccggct gtgcgtccgt tcgttgtcac agtaccgttt tcagacacag tgaaattctc 3129061 attatcaaca gtgattggct ggcgatccgt cgataaaata gggcgtccgt tgatcgtcag 3129121 ctgattgttc tcatttagtg aaaatgtgct gctttttgaa taacggattc catccgctgt 3129181 ttgaaccgga taaaaaagag cagctttttc attggtttcc gcactcatcg gaacttgatt 3129241 ttcgatcaat gcaatgtctg taggctggtc tgtggacttc aggcttccct gtgtaaagag 3129301 aggcttgagc tcctgcatat atactccggt attcacggaa ccgatttccg tccttgatgt 3129361 cccggccgga gattttgatt ctattctgct gagcagcatc tcagggaacg cgcgcataga 3129421 gccttgatca gctttatatc ctgatgtatt tgcgttagca atattatttg aaagcatttc 3129481 cgttcttcgc tgctgggcaa tcattgcgga tgttgctgta tataatcctt ttaacaaatt 3129541 tcccacctct aaaaatggca ttttttccag ttgtcatata ggaacgttcg ttctataata 3129601 aaaactcagt attttatcct attatcgtca tttaacatct tttcgtgaag gctttttcat 3129661 aaaaaaacct cattcttttt cagaatgagg tttgtgaaat cagcttagtt tgcgtttagg 3129721 aagcttgtcc atattatcaa gcatgacacc tgtgccgatg gctacgcaat ccataggatt 3129781 ttcagcaacg aggaccggta ccttcagctc ttcagcaagc agctggtcaa ggccgtttaa 3129841 gagcgcgcct ccgccggtaa taataacgcc gcggtcaata atatcagcag aaagttcagg 3129901 cggtgttctt tcgagcactt gttttgcagc ctgaacaata acagcgacag attcacgaag 3129961 ggcttcttca acttctttac tgtttactgt aattgttctt ggaagaccgg aaaccatgtc 3130021 ccgtccgcga atggaaattt cctcgtgacg tgcgtctggg aaaacagttg cgactttaat 3130081 cttaatatcc tccgcagtac gttcgccgat cagcagcttg tactcgcgtt tgatataatt 3130141 taagatttcc atgtcaaact tgtccccagc cattttaata gaagaggagg tgacaatatc 3130201 gcccattgaa ataaccgcga tatccgtcgt cccgcctccg atgtctacaa ccatgttacc 3130261 gcttggctgg aatatttcca tacccgcgcc gatagcggca actttaggtt cttcttcaag 3130321 gtacacatgt ttcccgccgc ttttttctgc agcttcttta attgcttttt gctcaacgga 3130381 tgtaatattc gtcgggcagc aaatgagcat gcgcggcttt gagaacaggc cttttacatt 3130441 cagcttgtta ataaaatgtt tcagcattgc ttctgttact tcaaagtcag caataactcc 3130501 gtctttcagc gggcgaatcg caacaatatt cccaggtgta cgtccaacca ttcgtcttgc 3130561 ctcttcgcca accgccagca ctttgccgct gtttttatca agtgcaacaa cggaaggttc 3130621 attcagaaca attcctttac ctttaacatg gatcagtaca tttgcagtac cgaggtcaat 3130681 accaatatcc cttgcaaaca tctatttata tcctccttga aaatctgttt cacagtaaat 3130741 atccacattg tgccctaatt atatatatta tcataaaata tagaaaaaaa gttggaagca 3130801 caataagttc tttacaaatt tttgcggatg ttttatgaac gatttcaaga aggcaatgcc 3130861 aggtgattac gattgctgaa caggctctcc ttcgagaatt tcatcttttt tatatttgag 3130921 ctttgtcgct tctcctcctc ttaaatgcct gatggattta tgataatcga gtatttcttt 3130981 cacttcgttt gccaagtcgg ggttaatttc aggcagacgc tctgttaaat ccttgtgtac 3131041 tgtacttttg gaaacaccaa attccttcgc aatgacacga acggttttct ttgtctccac 3131101 gatgtacttc cctatcttga ttgttcgctc tttgatgtaa tcgtgcacac cactcgacct 3131161 ccctaaaatg gatgtgagaa gtgtgaaatg agatccgtat tctgtaaaga gtcgttcatt 3131221 atgccgcttc ttcgttgtat ggttttaaaa gtaagtttgt gaaatatgcc cacgatccct 3131281 cacctcaaac actctctttg ttaggtttgt aacagtgtat tagcattctt ttgggaatat 3131341 gctaaaaact caataaggac aaggggtgaa acgaactttt tcagattcag caaactattt 3131401 cgcgtcacta aattttcatc tttacaacta ttgatcgctc ctgtaaaatg aaataagcaa 3131461 ttagttactt aggtaagttt tttagaagga gaccgacatg tcctacgtca acagacacct 3131521 cattcatcaa atcaaccaaa gcgcccgcct gattgccaag aaagccaatg aacagctaga 3131581 gccattcggc ctttattcat ctcaatggtc agttttatat tgtttgcgta cgatcggacc 3131641 aatgactcaa aaagagattt ggtcctattt aaatgtggaa gcgccgactg tgactcggac 3131701 gatcaaacgc ctggaggaga acggctgggt tcagagacgg caaggtgaag acaaacggga 3131761 aaaacttgtt gtcctcacaa aagaagccga gaaaaaatac gaagaaatca atgtgaaaat 3131821 gttgaaattc gaggaagagc tgcttgcaga tttccgggat gaagataaag aagctttttc 3131881 tcatttattc cgcatgtttt tacaacaatg aaaataagga agtgacatac atttgaaaaa 3131941 agcggatgcg atatggacca aggattttat tatggtcctg cttgtcaatt tatttgtgtt 3132001 tgtgttcttt tatacatttt taactgtatt gccgatctat acactgcaag agcttggcgg 3132061 cacagaatca caaggcgggc ttttaatcag cctgttcctt ctgtctgcga tcattacacg 3132121 gcctttctcc ggagccatcg ttgagcgttt cgggaagaaa agaatggcga ttgtatcaat 3132181 ggcgctcttc gccctatcat cttttctgta tatgccgatt cataactttt ccctgctgct 3132241 cggattgcgg ttcttccaag ggatttggtt cagcatttta acgactgtta caggtgcaat 3132301 tgccgctgat attattccag ccaaacggcg cggtgaaggg cttggatact ttgccatgtc 3132361 tatgaacctc gctatggcga tcgggccttt ccttggcctg aatttgatga gagtggtaag 3132421 ctttcctgta ttctttacag cctttgcgct gtttatggtt gcgggcttac ttgtttcgtt 3132481 cttgataaaa gtgccgcaaa gtaaggacag cggcacgact gtattccgtt ttgcgttctc 3132541 ggatatgttt gaaaagggcg cactcaaaat tgcgacggtc ggtttgttta tttctttctg 3132601 ttattcaaca gtcacatcat atctgtctgt attcgccaaa tcagttgacc tttcggatat 3132661 cagcggatat ttctttgttt gttttgcggt gacaatgatg attgcacgcc cgttcacagg 3132721 gaaattgttc gacaaagtcg gaccgggcat tgtcatttat ccatcaatcc tgattttctc 3132781 tgtcggactc tgcatgctgt ccttcacaca tagcggctta atgcttctgc tttcaggggc 3132841 ggttatcggt cttggctacg gatcaatcgt tccttgcatg caaacattgg cgattcagaa 3132901 atctccggct caccgctccg gttttgcgac ggcaacgttc tttaccttct ttgacagcgg 3132961 aattgctgta ggatcgtatg tattcggatt gtttgtagca tctgccggct tctctgccat 3133021 ttatttaaca gcggggctgt tcgttttaat tgctctgctt ctctacacgt ggagccagaa 3133081 aaaacctgca gaggctgaag gaaaagtgtc tattgcagaa taacttgtca gactgccggg 3133141 aaatcccggc agtctttttt ccattaaaac acggcgccct ctcggttgaa cgagagaacg 3133201 ccgcttatag caattattca atgacaggcc gcgcaggtga atcaggatct aacgaaaaat 3133261 cataggacgc ttcatcacga aacatcggat cggcatatat ggattgttga tcgttttttg 3133321 ttgcttttcg atacgaagaa aatgaatcat attctttctt tttccacatc catatgccgt 3133381 cttgatccgc ttccttgtgg tacacgttat gattgaccgt attaccttcg ttttctgtaa 3133441 agtcgtttcc gataaataat ctggaatcac cggccgtcaa tatattcttt tcaattgtgt 3133501 tgtttttcgt atcgtactgc agcagcagct gtccgccgta cagtcccttt gtgtcattcc 3133561 ggtacataat attgcgggca atcagagaat tgctggtgcc gccccgcttt ttgtcatatc 3133621 ctccgattga aataccggtg tacgcattgt tgtacacttt gttgtctgtg atctgaatgg 3133681 catttgcata ctttcctttg tgttcagacg ttgcttcaat cccaatatcg ttatcgtaaa 3133741 ctgtgttgtt cttaatttcg atatcgtgtc ctccatcgac ataaatcccg cccgctgagt 3133801 attcatctcc ataagcagga ttgccgtaag tcgagttttg ataaactgta ttgttttcta 3133861 cgactccgtt tcgcacgtaa tcgtttttat ccgcggttcc ctcataacca attagatcaa 3133921 tcccgatgtt attattgttg cggaccacat tgcctgcaac tgtgaagccg tcgatattac 3133981 cgttcagcac aactgcttca ctcgctccaa gcgtcagttt ctcaactgta ttgtcctcga 3134041 ttcggatgtc tttcatgctg ccagtcccat aaactgcgat tccgtgagca tttccttcat 3134101 ccgctgttgt cttaatcccc cggatgtgat tatccttaat ggcgatatga ctgctggacc 3134161 ctgatacata aatccctata gcagttgctt cctcagatga aacagaaaga tcttgaattg 3134221 ttaaaccgct gatggcaatg tcatgtttat cgtgaatacg aataagcggt gtttcatatt 3134281 cagcgttcgc aacggattca ccgctaatca cgacgttttc attttcatag tttcggaatg 3134341 tgataggctt tccgtccgta ccgctgtgct ttacatcaag ggtctcatga tacgtgccct 3134401 cccgaatcat gacagttgtg ccggcagcag ccttctcaga tgcgtgtgcc aatgtacgaa 3134461 acggcttttc ttttgttcct tcattttgat cactgccatt tggcgaaaca tacagataat 3134521 ccccagatcc ttcctcattc gcttttgtct tatcataaac gaaagcgagg atgacagacg 3134581 ttaaaacacc cgccaaaaga ataaaatacc attttctcat tttcgattcc catttcgttt 3134641 tagaatagat ttctaaaacc attataaatg ttctatttat ggaaaaccat ttcaaaaata 3134701 tgaaaatata ccgtctaaat agatcttatt cagcctggcg gacctgcgca tgttcaactg 3134761 tttcaattgc caatgatgca ggcgggtgaa cacgcatcag aacaatgtag aaaagaaagg 3134821 aaatcagcac acctacaaac caagaaatat cgtataagct cttcaataca ggaacataca 3134881 tgccaatcag cgaaatcagc gctcctaaca ttgtggctgc aaacgcacgg taattgtagc 3134941 ccttccaata cacataccgt cctgtttcgg aatacaggtc atctaccgag agctcacgtt 3135001 tgcgaatgat aaaatagtcg gccatcatca cgcctgccac cggtccaagc atgccgccta 3135061 ttaagccaag aaacgcatac acgcttgtcg cgctctccat cagcttccac ggaaccgtaa 3135121 ataaagcgag caacgctgtg ataaagctgc cacgtttgaa attgatatat ttcggcaggg 3135181 cattcgctat atcataagcg ggtgatacga tattcgccgc gacatttaca gagatcgtgg 3135241 cgatgcagag tgtgatcacg gacaagacga tgacataagg gttatcaaac cgcgccaaaa 3135301 tatcgacaac atcccaaatc ggctctccga acgcgacctg cgagccggag gtcaccgtaa 3135361 tacttgcgaa tgcgaacagc gcaaacgttc ccggcaaacc gtaaaattgt cctttgattt 3135421 gctctttttg tgtttcagca aaccgtgtaa aatcaggtat atttaagatc aatgtcgccc 3135481 agatgccgat gatgccagta actccggcag caaacggcca gaatgtttct gaaaacgtat 3135541 gaaactttcc tggttgagag tatatcgggc ccaatcctcc agcaatatca acggcccacc 3135601 ataccatgcc gccaaatacc agatacacta aaggccctgc ccacacctca aaacgtttaa 3135661 tcgactccat gccgtgatgc aatacgagta aatgaatggc ccaaaagaat acaaaggaaa 3135721 gcaaaccgga caagtgaatg ccgagaatgt tccactcgcc gccaatttct ccccaacctg 3135781 gccacatatt caaaagcaaa atgttcagtg ccgtgctacc cgcaaaggtc tggatgccaa 3135841 gccacatgat agctgtaaac gcccttagaa gcgcggggat attcgcgccg tatatcccgt 3135901 aagaagcccg aatgatcact ggaaacggca gcccgtattt tgtccccgca tggccgttta 3135961 aggcaagagc gccaaatagg ataagtgatg ccgtaataat gatcgccagc acctgccaag 3136021 gcgaaaggcc gatcgcaatt aatcctccca cggtcgcgta ggtcggtatg ttatgtatac 3136081 atcccatcca aatggaggca aagttcattg ctttccacgt ccgtttttcc tgtcccaaag 3136141 gcaccagatc ttcattgctc agcctgttgg attgctgctg actctctttt aatttcatag 3136201 ccggctcccc tttccatatt gtctatatgt cgtcacacgt tatgtttttt gacattagat 3136261 gtcacttaat ataactgaag agtcagacaa taacactggc tatgatatac aattttcccg 3136321 tttgtatttg aacagcttaa acaagaaaaa gagacagacc tcagagcccg tctctttctt 3136381 aagatgcagt tttcattaat gcagcaaatc tcacagccat taacaggctt gctccgcccg 3136441 ctataatcat aatgattccc atcatatcaa aatgggctgc cgtgatttct ttaccaaaaa 3136501 gaatgccaag gatcaccgaa gacaaaatcg atcctaggta acggcaggtt tgaaacaggc 3136561 ctgaagtcgt tcctaccatg ttggaaggac tcgtttccag catcgctgcc tgaagcgcga 3136621 cattgcccag tccgtagcct atacccaaga gcgacagaat gaggccttta ccgatggtct 3136681 ggacattgat aaaaaagatg gttaagagca cggctccagc cgtcatcaaa agcgctcccg 3136741 caaagatcgg cttgacgaca ccagatcggt cgatccattt gccggttaga ggtgacacaa 3136801 cgatgctcat tccagacata aacagcataa acaggccgct cgtttgaaca gaaagatgca 3136861 tttcatcctg aaagtaactt ggcaaaccaa aaaataaaca atagaagaaa acattcaata 3136921 aaataaactg aacatacacg gctgacaggt ttcgctgtgt tttaaacaga cggacatcaa 3136981 taaacggctt atccgttttc agctcgcgcc agacaaacgc acagagcaga agcaagccaa 3137041 gcacaccttc aaccgcatgc ggcgacgtgc tgaacgacag caaaaaggat agaaggaaaa 3137101 tgattccccc ggcaaataaa acaattccaa gaatatcgag ctgccgaata atggttttga 3137161 ttcctgcccc ttttttctga tctttcggga acatatacag gcccaataag aagctgagga 3137221 taataaacgg caaattaacg ataaagatcg ccggccagcc tccccataca atcaaaaacc 3137281 cgccggctgt cggccccagc gccgtcatgg cggacgcaaa aatagagagt acagccaagg 3137341 ctgaagcttg gcgctcatga atatgattcc gaatcaagcc gacacctgac ggataaatcg 3137401 cactgctccc caccgattga aacagccgca tgaccaataa tgtcataaac gtcggcgcaa 3137461 acggcgcccc gatggcagaa accgcaacaa gaataagccc gaataaaaac aagcgtttcc 3137521 gcccaatcaa atcaccgagc tttcccgtta cgggctgcgc tacggcactc gccaagtaaa 3137581 acgaggaaat cagccaggaa accgttgtaa acgagaggtg aaactcatgc tggatgctat 3137641 ggagcgcaag agagatcata gacgagttca gcggattcag cattgttccc gaagccacag 3137701 ctgttaaaaa aacagctcgg ctttttttcg ataacatcat ttcacttgtt ccagaaactc 3137761 ttccgttgtc cgcgatttac cgattctcgg gaaaataaag cgcagtgtgg cttcatgctc 3137821 ttcatcgcta aatgtggaca tggcatctgt aataaaaatc tgctgatagc caagctgaaa 3137881 tgcctcccgt gctgtgcttt ccaccccgat attcgttgcg atgccgcaca atacaatcgt 3137941 atcaatgccg cgacgtctca gctgcaagtc taaatctgtg ccaaaaaaag caccccattg 3138001 ccgttttgtc acagtataat cgccatcctg cacaccgatt tccggaacaa attcggccca 3138061 gtccgccggc atttcccctg aacctccctg cgcaggctca tccgtttgcg gcttcagggc 3138121 gtccgctcca tcatgaaagg ctacatttac aaagctgatg aacccgttat gtttccgaaa 3138181 ttcatctacg agctttttcg cgttcgggac aacctggccg ctttgatcaa tcggcacaat 3138241 tcccttttgt aaatcaatga taaccaatgc tgttttttga aaatcaatgt tgagtgtatt 3138301 catcatacgt ctcctcctga tactgttagt gtttctcaca ttgcatattt tactcttcac 3138361 actgcctaag ttcttttatg atgcttgtga aattctcaga aggagcgttt tctcatgatt 3138421 tttcttttat gtagtagtaa caggttgtgc atacgaacaa accggcaagc actgtaatca 3138481 taaagggcgt catcgcttca tcacctgcct gctgtctatc ggttcctgcc tgaaaatgcc 3138541 catgaatttg cggcggtcca tccaaagcag gataagacac ataaccatta atatcgtgct 3138601 aagatcctgc acgccaatat caaaacaata gttaatcaag acgatgttca caataatggg 3138661 cataaaaata accgccccta atgcagccgt tcgcggaatc agtaataaaa cagctgccag 3138721 gatttcacca aaacctataa acagttcata gacatgagaa taaccgaaaa atgtccacgc 3138781 gatcgtaaac cccttcccgg cagccgcctc gatttcaggc gtcacctcgc caaactggcc 3138841 aattaccact ttcgccagac cgtacacgaa aaaattaaag gctaaaaaca atcggaacgt 3138901 cgcgggaatc gacttgcgta ccgctttcct cagcctgccg cctttattca tcatacatcc 3138961 ccctcagtgt attatttgat gtagtacact taatacagta tagagtattc taattaatgt 3139021 caattccctt ttcagctcat atgaatagtt tcttttatag atacaaagtc ttatatcgca 3139081 aaaaatgcca ttctccttcc tttccatccc tcgataacat ttctcaaaaa ccatgtcagg 3139141 aaatcttaca tgaaaatgtt ttatcattct tttttctcta taatgaagaa atataataat 3139201 tgctttttat tctgaaagat acggaggaat gagacatgca aatgggcgat acagttttta 3139261 tgttcttttg cgctttactc gtgtggctga tgaccccggg attagcgtta ttttatggag 3139321 gaatggtaaa gagcaaaaat gtgctgagca ctgccatgca cagtttctct tccattgcca 3139381 tcgtttccat cgtttgggtg ctgttcggat atacacttgc cttcgcacca ggcaattcaa 3139441 tcatcggcgg gctggagtgg gcaggcctca aaggggtcgg atttgatccg ggagattaca 3139501 gcgataccat cccccactcg ttatttatga tgttccaaat gacgttcgcc gttctgacta 3139561 cagcgattat ttccggggct ttcgcagagc ggatgcgatt cggcgctttt cttttattct 3139621 cggttttatg ggcctctttg gtttacacac ccgtagcgca ctgggtatgg ggcggcggct 3139681 ggatcggcca gcttggagcg ctcgatttcg ctggcggcaa tgttgttcat atttcctccg 3139741 gggtggcagg acttgttctt gccattgtgc tcggcaaacg gaaagacggt acagcgtctt 3139801 ctccgcataa cctcatttac accttcttag gaggagcttt gatttggttc ggctggttcg 3139861 gctttaacgt cggcagcgca ttgaccttag atggtgtggc catgtacgcg ttcatcaaca 3139921 caaacaccgc ggctgcagcc gggatcgccg gctggatctt agtagaatgg atcattaaca 3139981 aaaaaccgac aatgctcgga gcggtatctg gggcaatcgc cgggcttgtc gccattacgc 3140041 cggctgccgg atttgtcaca ccgttcgctt ccattattat cggcatcatc ggcggagctg 3140101 tttgtttctg gggagtattc tcgcttaaaa agaaattcgg atacgacgac gcgcttgacg 3140161 cctttggcct gcacgggatc ggcggcacat ggggcggaat cgcaacagga ttattcgcaa 3140221 caacctctgt taactcagcg ggcgcagatg ggttatttta cggtgatgca agcttaatct 3140281 ggaaacaaat cgtcgccatc gccgccactt atgtttttgt atttattgtc actttcgtta 3140341 ttattaaaat tgtaagcctc ttccttcccc ttcgcgcaac tgaagaagaa gagtcacttg 3140401 ggcttgactt aacgatgcac ggggaaaaag catatcaaga ttctatgtga ggagtgacgc 3140461 tatgagcggt caaatgttca aggtagaaat tgtaacgcgt ccggcaaatt ttgaaaagct 3140521 gaagcaggaa ctcggaaaaa tcggagtgac ctctctgact ttctccaatg tacacggctg 3140581 cggccttcaa aaagcacata cggagctcta tcgaggggta aaaatagaaa gcaatgtata 3140641 cgagcgttta aaaatagaaa ttgtggtcag caaggttcct gttgatcaag tgacagagac 3140701 cgctaaaagg gtgctgaaaa cgggatcacc aggtgacggt aaaatatttg tctatgaaat 3140761 cagcaatacg atcaacatcc gcacaggcga agaaggacct gaagcacttt aatatcggta 3140821 cgagattcgg acactccgga tctctttttt tgtgcacaga atccccccag aaaccgcgat 3140881 tcctcttcga attctcttca agcgccgtta tttcagacaa tctctatttt tatttgaaac 3140941 ttttcatgag taagattagt ctactaaata taaaaatgta aaaggtgatt atttgaacta 3141001 cgaaattttt aaagcaatcc atggactatc tcatcacaat tcagttctcg attccattat 3141061 ggtcttcatc acggaatatg ccattgtcgc ctatgccctt atcctattgg caatctggct 3141121 gtttgggaac acacaaagca gaaaacatgt gctatacgca ggcatcacag gaattgcagg 3141181 ccttgtgatc aactatttga ttacgcttgt ttatttcgaa ccgcgcccgt tcgttgcgca 3141241 tacagtgcat acactgattc cgcatgctgc ggatgcttca tttccaagtg accatacgac 3141301 aggtgcatta gcgatttcta ttgcgatgct tttcagaaac cgcaaaatcg gctggccgct 3141361 tgtcattttt gggcttttga caggcttttc gagaatttgg gtgggacatc actatccggt 3141421 agatgtattg ggcagcctcg ttgtcgccat cattatcggg ttccttttct ttagattttc 3141481 agatctgctt cgcccgttcg tcgatttggt cgtgaggatc tacgaagcca ttatcaataa 3141541 actgacgaaa aaaccaaccg atcaaaattt ctaagaaaga caaaagccgg cgtctgaaat 3141601 caagacagcc ggctttaata tttctcatac atctcttgtt ttcttcgctt cgccaacaca 3141661 tataaaccat aaaacaaccc aattccaaca gcatcgatga gcacatcccg gatacaacca 3141721 ttcctgctga agaagagctg aagaacttct gtgaaaaaag caaacgcaaa tgagccggct 3141781 gcagctgatc ttatgctgcc ccgctgtttc cacagcaaat atgtcagcac aaagaaggaa 3141841 aacgcgtgtc cgattttttg aataaacgct tcaggtacag taagctcagt aaaatccata 3141901 actaaaaatt gagacagatc agggtgcggc tgaaaatgaa aagccaccgt ttgcgatacg 3141961 accatgccgc tgaagctttc cgtacagaca gaaagcagga taaaaaagat ccagcctgcg 3142021 agcaataggc ggttcatgac ataacctcct ttataacgta cgtgcctaca tgtaactaca 3142081 tagacggtaa aacaaagcaa aaagtaacag aaaaaaacgc ccatcacaag gatagacgtt 3142141 ttcttcatta agactgttca gtgtcttctg ttgtgctgct ttctttagaa ccagatttgt 3142201 cagttgaatc atcctttttc tcaccggatt tttcttctgt tcctttttca gttgatccgt 3142261 cctttttctc ggaagattgc tgaatggatt cttctgtttc ttgggtggca gctttttcaa 3142321 tagaagaaac tggtttgtcc ataaagttta acggattcat tgcaacccca tctttacgga 3142381 tttcaaagtg cacgtggttt ccgctgtctt cactgtaaag gttcttgcca gattttccga 3142441 tcacttgatt ttgttttact ttgtcacctt gctctacgct tacttcggaa agagattgat 3142501 acacagtcga taaaccgtcg gcatgttcta cttccacaac atatcccagc actggatctt 3142561 tttcagcttt aacaaccgta ccgctcagag aagcagagac atcgaaatct tttccgtctt 3142621 tctcagctaa gtcaattcct ttgcttaggc tgtacgtgtt attataggta acgagtgctg 3142681 cttctttctc ttcttttgcg gcatcggttt catagaactt tttcacaaca gaaacgtttt 3142741 cagaatcaac aaccggcatt gcgacatttt ccattgactt tcctacttca actgcatcgt 3142801 cgttgttgtc atatgcggag tttccgccgt tatcagccaa ctgatccttt acctcatcat 3142861 ttgatactga ttgataccaa aggacagctg ttaaaatgac ggccgcactg actaagtaaa 3142921 ttgcagggaa cacccagcgt ttacgaaaaa actgctgaag ttttttgact tgagaagttt 3142981 tcttttcttc ctctctcatt gtttcatcac ctcagcaaca ttctgaacac ttttctgaaa 3143041 atatatacaa cctatccaaa aaaacttttt tagatgtagt ttgcacagac tgaacgaaaa 3143101 tatgtatttt tttgagagga gtgccaaaaa cgtatgaaca tgacattgcg tcttgctgaa 3143161 catagagact tggaggctgt tgtggcgatt tataattcaa cgattgcttc tcgaatggta 3143221 acagccgata ccgaaccggt aactcctgaa gaccggatgg aatggttttc gggacataca 3143281 gagtcacgtc cgctctatgt ggccgaggat gaaaacggaa acgtcgctgc ctggatcagc 3143341 tttgaaacat tttatggaag gccagcctat aataaaacag cggaagtcag catatacatt 3143401 gacgaagcat gccgcggcaa aggtgttgga tcatatttgc ttcaagaagc gctccgcatt 3143461 gccccgaatc ttggcatccg ctcacttatg gccttcattt tcgggcataa taaaccaagc 3143521 ctgaagctgt ttgaaaagca cgggtttgca gaatggggac tattccccgg catcgccgaa 3143581 atggacggga aaagatacga tttaaaaatt ttagggagag agctttcatg attagtctgg 3143641 ataaagatga aaacgaaatt gaacatcata atgaagaaaa tagccttgtt gaacaggaga 3143701 ctgcacctgt tggacaggag agccgccagc tgagcgcctc cgctgtcaag tcgctatccg 3143761 acattgccaa gtggggcaaa atttctggca tcttgttaat cattatggga tcgcttgtca 3143821 ctctgtctgt tttgatgaca gtgattggcg ccatcccggg cgtactgctc attatttcag 3143881 gcgtattttt gatgcgctca gcaaaagcag ccgcggaagc cgaaggaaat ctaaccggca 3143941 gcgctggcga aagcatgctt gaaaattacg ggacatttat aaaaatgcag ctgttttatg 3144001 cagcatccag tatcgttact gtcctgatcg ggatcattgt agccattttc gtgctggtgg 3144061 taatcggcat tgctgctttt gagaacacgc cttcgtatga tgatccggat tcttattatt 3144121 atgaggatga tccggtgttt gaataatgat gagacaggac agggcatgag ttccatataa 3144181 acggaaccat gcctatttta tttgactatt caaagcaggc cggcgtaaac accaaatcct 3144241 gaagcaagca tacaatagac atctctagta gaggaaatca acaaagcaac gctgttaccc 3144301 agaaatgaat atcaaaaaaa cggatgaagt cggaatcaat ccgaaaccgc actttttatt 3144361 tcgggtgtct gcatgcaaaa aaacacaccc ggatcgtctg gaaaatctca acaatccggg 3144421 tgcagatctt ctttaataca tttttttgcg tctgtcttcc tcagtcaaaa attcaacaaa 3144481 actccgcatc gcaaaaggct cttcctttat ttgtcgtgcg taggagcttt tccgctcttc 3144541 tgaaaggatt tcgctctttt tgatcctgtt cagcatatag atgtgaaccg ttttttggat 3144601 ttgtttatgc tgatagcctg cctctttaaa aaatgcgagc ccgagcgccg ccaaaagggc 3144661 gaatatgcct gcgctgatca gggactccct gtcagctgaa gcatgaaata gaaaagcagc 3144721 taaattaaag agagagaatg cagcaagcgg aatagcaaga aaacggtaaa tgacggtttt 3144781 tttcatgaaa ggctgtacgg ccttttgaat tttttgcatt tctgttttga tgaaccccgg 3144841 catttgttcg actctgtaaa agttcatata atcctccccc tttatttgat gtttcaagct 3144901 tcacgaacgt tatcatatgt gtttatttta acgcaggtgc aagctggttt taaagaaatc 3144961 tgcccgtatt tttcacgaag aatctggatc gccgctcttt attcttttaa aatgtgagtg 3145021 ttataatttg taatgggaat cagatcactg ttattcatgg aatactaatg gcaatcttct 3145081 tgataaatat gaatgagcgg ggttacaaag tgagtatttc ttccatcctt ttatcacttt 3145141 ttttcatttt aaatattctt ttggccatca ttgtcatctt caaagaacgg cgcgatgcca 3145201 gtgcatcttg ggcgtggctg cttgttcttt tctttattcc cgttttaggc tttattttat 3145261 acttattatt cggccataat ctcagacgca agcatttgtt tcaatgggaa gaccggaaaa 3145321 agattggaat tgaaaggctg ctgaagcatc agcttgaaga tttagaaacc aagcaatttc 3145381 agtttaacaa ccgggcaacc tttgataaca aagatttaat ttatatgctg attatgaata 3145441 accatgctgt gtttacagag gataattcag ttgacgtcat tacagatgga cgggataaat 3145501 ttcagcggct gctgagtgac atttcaaagg ctaaggatca tatccattta cagtattata 3145561 tttataaagg cgatgaatta ggcaaaaaat tgcgggacgc tctcatccaa aaggcgaaag 3145621 aaggtgttca ggtcagagtg ctttatgatg aactcgggtc cagaacgctg agaaaaaagt 3145681 tttttaaaga gcttcgcgag gctggcgggc atgtggaggt ctttttcccg tcaaagctca 3145741 ggccgattaa cctgcggctg aattaccgga accatcgaaa gcttgtgatc atagacggta 3145801 tgaccggtta tgtcggaggc tttaacgtcg gagatgagta tctagggctt aatccgaaat 3145861 tcggttattg gcgggatacg catatccggc tgcaaggaac ggccgtgcac gccatccaaa 3145921 cacgattcat ccttgactgg aaccaagctt ctcatcacca tacgctgaca tatattccaa 3145981 atcactttcc tgattacggc ccaaaaggca acgtcgggat gcagattgtc acaagcggcc 3146041 ctgattcgga atgggaacaa attaaaaatg gctacatcaa aatgatttcg aacgccaagc 3146101 gttccatttt gatacaaaca ccttatttta tcccagatgc aagcctgctg gatgctttaa 3146161 ggatcgcttg cctttcgggc attgacgtta acattatgat tccgaacaag cccgatcacg 3146221 cctttgtata ctgggcgaca ctttcgtata tcggcgatct gctgaaagcc ggagccactg 3146281 tctatattta cgataacggc tttattcacg cgaaaaccat cgtggtggat gacgaaatcg 3146341 cttcagtcgg cacagcgaac attgatgtcc gaagcttcag gctgaatttt gaggttaatg 3146401 catttattta cgatatcacc attgctaaaa aactggtttc aacttttaaa gaagatttgc 3146461 tagtatccag aaaattcacc tatgaggagt atctgcagcg cccgttgtgg attcgaataa 3146521 aagaatccgt ctcgcggctg ttgtcgccga tcttataaga tgcgtaaacc cccggccttt 3146581 acggccgggg gttttcctga tggtcacagt aaatgatgat tgcctcccgc aaaaaagcgg 3146641 caagaccttc tccatattga ttgattgaat cggtaaatcg ctcgtcagtg atatacactt 3146701 ccccgagtcc tctgaaaatg tcgagtgtgc aatcgtaatg atattggcaa atatgatcgc 3146761 gaaatgcccc cacagcggcc tgaatctctg catcatcggg cccatgcttc attcgcgccg 3146821 caattcgtct gtaaatcgaa tcaaattcag ccatgatcgt gcgccaatca tctgccgagt 3146881 atgcagatgt ccttttctct gtttcttctg cgatttcctt tccatacagc tttctgactt 3146941 catcagcgta tgtctgctgg tgctcttcaa tgtctttcat gcttaatccg gcaaataaat 3147001 ccctcttatt catcgtttcc cctccatcaa cggacaaaag cgtcctgtca attgtttgaa 3147061 tcatctcatc cattctttgt tttttcttca tcaatatctc cttttgcgac tgaagtgccg 3147121 ctttccggtc aaaattcgga tgatccagca tctctttaat ctcatccaga cgaaacccga 3147181 tttccttgaa aaataaaatc tgttgcagtc tttccaggtc tgcgtcactg tacaaacgat 3147241 acccagcatc agtaagcgct gaaggattca gaagctcaat attgtcatag tgatgaagcg 3147301 tccgaatgct aacgcctgat atctccgcca cttgtttaac ttgatatttc atacataaca 3147361 cctcctcttt tttatcgtaa acaatcacgc aacgttaggg tcaatcccca aaatgttatt 3147421 ttctatatac aaaacttctc acaaatagtg tataaaagaa aagtgagtat ttttttgtaa 3147481 aggggagcca gtatacatga atcctgaaac aatgaacaaa accctcatca gcatttcgaa 3147541 atggggaaaa gctacaggca ttttatttat tattatgggc gcaattaccg cgctttcagg 3147601 cgcgttcttt tttctaatcg gtgccgtgcc aggcgtactg caaattattt ccggtatctt 3147661 tttgatgagg tcagctaggg aagcaggcca aatggctgaa cacaatagcg gacagtctga 3147721 agacttaatg ctggagaatt acgcgaaatt cgtaaagatg caagggattt atttgatcgt 3147781 aagcattgct gtatccattc ttgcgattat cgccttcttc atctttttaa tgcttgggat 3147841 tgctgacggc cttttcagcg atacgtacag cacttattaa tgagaaaaac ccggagctgg 3147901 ctccgggttt tttattattc cgcttcgctt accactgtga agcgttcatt tttgtgttcg 3147961 ggatgttcaa gctcgtccaa cacggcaatg gcataatctg catagctgat atagctgtct 3148021 ccttttgcat ttacgatgac attgtctttt cctttttggt aagagccagt ccgttttcct 3148081 gctggatcaa aaaatgccgc aggactgagg aacgtccagg aaatggagtc tgtctgctgc 3148141 aaatctttca ggttctcgcc ttgatttgat gcagttggca aatattcttt cggaaattcc 3148201 ggcgtatcca ttaaacgggt tgttttggct tcatcaacaa acaggcttcc cgctccgcca 3148261 acaacaagca atcttgtgtg cttcgcgtcc tttaaaatgc tgatgagtgc tcttcctgct 3148321 tcaacatgaa gatgttcttg gccgggtgct gctccaaaag cgtttacgac cgcgtcgaaa 3148381 ggcttgatgt cttccgcagt cagttcaaac acatcttttt ccaaaatcgc tacgtcttgc 3148441 tcctgcactt ttgaagcgtt tctgacgatg gctgtcactt catggcctct ttttttcgct 3148501 tctttcaaaa tctcgtttcc cgctttcccg cttgcgccta taataccaat tttcattttt 3148561 catttcctcc ttatttgtaa caattttagt tacatgttag cggtgagaag tcatcccttt 3148621 tgattaaaag agatgattca taacatcttt taatgacttg cttgccagtt cattttccat 3148681 cgctctttgc acactttcaa acgtttcatc cagagcgttc tgaatttttt tccctaccgg 3148741 acatttcgga ttcgggtttt catgaaccgc aaagagttct tcttgctttt ggacagcccg 3148801 gtacacttct aaaagagaaa tatcagcagg atcttttttg aggcttgcac ccggcacccc 3148861 ggcgcgtgat gtgagaatat cagctttttt cagcaggctg atcattcttc gcacaactac 3148921 cggattcgtg ttgacactgt ctgcaatgat ttctgaagat gttttttcat ccatcgagat 3148981 gagggataaa atatgaatgg caacagcaag acggctgtta atcatgtttt ttcaccaccg 3149041 ttgtaactat aatagttaca tttgattcgt ttgtcaacat ctaatataca ctaaatacat 3149101 gggttttgtg caccgttttt agtcaataga acggccggat gcactccggc cgcgtcttat 3149161 caaaataaga aatatctttg tccaagtggg acataatcga caggctggca agacaattcc 3149221 tccccgtcag caaagacctg ataggttttt ggatcaatct caatcttcgg caaagccgaa 3149281 ttcagcttca tatccagctt gctcagcttt ctgatatttt tgactggaga aatccttttt 3149341 tccagcccta agctttccgc cacaccacgc tctatgcttg cctgagacat aaatgtaatc 3149401 gaggttgagc ggttggcttt tccgtaagac gcatacattt ggcgcatgaa aaccggttca 3149461 ggagtcggga tggacgcgtt cggatctccc atttgcgcac gtgcaatcat gccgcccttt 3149521 aagaccagtt ccggtttcac gccgaaaaat accgggtccc acagaacgag atcagcaagc 3149581 ttcccttttt ccaccgagcc gacctcatgg ctgagcccgt gcgtaattgc cggattaatc 3149641 gtgtatttgg caatgtaccg ttttgcgcgc acattgtcat tcccgttttc accggcaaga 3149701 gcgccgcgct gttttttcat tttatcggct acctgccatg ttcggatgat cacttcaccg 3149761 acccgcccca tcgcttggga atccgatgat gtcatgctga tcgcacctat atcatggaga 3149821 atatcctccg cggcaatcgt cgccgccctg attctggaat ggctgaatgc cacatcttca 3149881 ggcactttcg catctaaatg gtggcagacc atcatcatgt caagatgctc atccatcgta 3149941 ttaacggtat aaggaatggt tggcgttgta gatgacggca gaatgttcgc gtaagaggcg 3150001 agcttcataa tatccggagc gtgaccgccg cctgcccctt caatgtgata agtatgaata 3150061 acccggtccc cgatcgcgtc gagcgtgttt tccaaaaagc ccgcttcgtt aatcgtatcg 3150121 gtatggatgg caacttgaat atcagcctcg tccacgactt ccatacacgt tttaatggcg 3150181 cttggcgtcg ttccccagtc ttcatggagc ttaagaccga tggcgcctgc ttccacctgc 3150241 tcgatcagcg gcgctttatc ggatgcattc ccttttccta agaagccgac attgatcgga 3150301 aactcctcgg ccgcttccag catcctcgcc atataccacg ccccggacgt acatgttgtc 3150361 gctttgcttc ctgtagcggg tcctgttccg cctcccaaaa gggtcgtcac acctgaagaa 3150421 agcgcaactt ccatctgctg aggacaaata aaatgaatgt gcgtgtccac tcccccggct 3150481 gttaaaattt tgccttcacc ggaaatcacc tctgtccccg ctccgatgac catgtgcgga 3150541 tcgactccat ccatgatatc aggatttccg ctttttccga caccgacaat ccggccgtct 3150601 ttcacaccga catccgcttt gacaatgcct gtgtaatcca atagcacgac gttggtgata 3150661 accaaatcca aagcgccgtc cttccctgtg attctgccgt tttggcccat gccgtctcgg 3150721 atagtttttc cgccgccaaa gatcatttct tcaccgtata ctgtgaaatc cttttcgact 3150781 tcgatccata aatccgtgtc gcccaatctg attttatcgc ccgttgtcgg gccaaacagt 3150841 tccgcatatt cctcccgtga cattttcatc ggattacacc ctccatccag ccggcttgtt 3150901 ttaagttggc caacgttttt tctttgccgc gttcatcgat aaacgtgtcg gccattccgt 3150961 tcagccctct aattgtcttg cgtcctctga tttccactag tgagaccgtt ttctgctctc 3151021 ccggctcaaa acggaccgac gtgcctgatg gaacatcaag acgcatgccg atcgccagct 3151081 cacggtcaaa taataaagcc ccgttggcct ccgcaaaatg aaaatgcgaa ccgacttgaa 3151141 tggagcgtga tccggtgttt tttaccgtta cctcccgtat ctcacggcct tcattaatcg 3151201 taatggttcc ctcagcaatt tgaaatgctc ccggcttcat gacttcacct ccgcagaaat 3151261 tggctgatgt accgtaacaa gctttacacc atccggaaat gtggcctcca cctgaatgct 3151321 gtccagcatc tcaggcacac cctccatcac atctttttcc gttaatacat ggcggccggc 3151381 ttccatcagc tctgctactc ccttcccatc acgtgcgcct tccataataa agcaggtgat 3151441 ataagcagca gcctcaggat agttcagcag aacgccccgc gcctttcgct gtttggctaa 3151501 ttcccccgct gcaaaaatga gcaatttctc ttgttcaact ggtgtcagtt tcatctgtag 3151561 tcctccttct tttgtcatat aaagcagatg cggctactac gaatttgcgg aacagtcagg 3151621 cgggacatca cctccctttc ttcgagaatg ggggtcatac ggtaagatgc ctttcaaagc 3151681 ggcatgccgt ttcttcatca gccttgccat ggtcaacaac cgttcccctg tcgatcacgg 3151741 aaagatcaga ttaacgcgtt ttccagactg cgctcgacta agataacaaa tgtctttttt 3151801 tctggaaatt tctataataa cttgtctgac tagttcgaca attaaaatct gaattccttc 3151861 caattgttta ttaagtaaaa tatttttcag atttaccatc agcgctctgg tgattgcaag 3151921 ctgctgctgt tgaccgcctt ttcgttttga acaaacgttt gattaaaaca aatagccccc 3151981 tctgtttagc cggagtcggc ctaatacagc gacaatctgc cccgggcgaa gctaaggctg 3152041 tgcaaaacca tcgattgatc ataaccagac gttacattcc tgatggcagc ccgttgtttt 3152101 gctccgcaac cggaagcatg gcatggaggc cagtctgagg cgccgacctc cacgataccg 3152161 agaacccgac tattgccatt aactccgcat catggacggt cacttcgctg atcgccaccg 3152221 ttcctcttaa tgagtgaaga attccggcct tcactgaatc cccgcttgtg tcgatatcaa 3152281 ctgttttctc gcactcccgt ggcttccgac actttcttcg gtgcagtaca ttccgtcatc 3152341 aaaacccctt tgtttgattt cttcaaatga tgttataaaa gtttacaact tatgtcatca 3152401 ttatatagaa gaggcctatt aattcaaaga atatttaaaa aatttagtta ccttgaccaa 3152461 atcagcttct ttttttgtta tatttattca catcagaaaa agcgaaaaaa aaagacaaga 3152521 aacatttcgt ttcctgcctc ttccgtacga ttaatcttta tctgaaaatt tatccttggc 3152581 tttcccgata tccttttgga tttcgccttt tgccttatct tttttgcctt cagcctgcat 3152641 gtccgttctg tcagccatat ctccgacttt atccttcact tctcctttgg ctttattgaa 3152701 gccgcccttc attttgtctt ttacactatc gttacccatg ttaattctcc cctctcaatt 3152761 atgtgtgtac ttgttaactt cccgatctga gaggcaataa acattctaat gttatttatc 3152821 gatttcgtag cgctctccgt aacggagcac cttgtatatc gccagcccgt ctgatgactt 3152881 tttctccgaa tatcggaccg gcagcagggc aaaaaacaca taatacgtag aaaaatagac 3152941 aaactgatag aaaaacacat tcggctttaa tacactgtgt ataatcagca gattgattgc 3153001 aaaaatcgtg atgaggttaa acaagcagcc ccctgcatac acgagtgcat ttgagaatcg 3153061 attgtcaatt ttcaactccc cgtaccggca aaaagaatcg ataaaataaa tcgttctgaa 3153121 ccgtatgggt ccaattttaa gcagcgtttt tcccatgcct atatccaacg atccctttcc 3153181 gccaaaaata aaagccataa agctgtgccc tgaaacatgt ataatctgta caagcggcag 3153241 aacaatgagg aaagaccaca gaaacttcac catatcatta aaaccaaaca ttgaattccc 3153301 cctcacatgc atatctgcat cccaaaacgg cttttgttca aaaaacagtg ctgtagcgat 3153361 ttttcctgtt ctccccggaa ataaacgttc cgatgctccc ctttttttgc ataaaaaaaa 3153421 accatctgcc agcagatggt tttgtctcat acttcatata aacaatcgtt cctttgaatc 3153481 atctctctca tgctgaccgc tttttcataa aaatacaccg cttctttata ttgttcgcga 3153541 tgactgaaat aagaggcagc atctaaagca aattcttcaa tatatacata caggcccttt 3153601 tcttccatat aatcaaatac ttcttgaatc atattcaaat tgacagattc cacatataat 3153661 gcctgcagaa atttatattt tgccagactg aagaagtcgt ttcgtttttg ggcaatggca 3153721 atcccttttt catagtaccg tatcgcggct tcgctatctt gttttttgaa aagaacgcga 3153781 gtcaggctga agagcgcttt tggaagctgt tccagctgat aatcctcgaa gacaggaagc 3153841 gctttttcaa agtattcggc ggcctgatcc agctccccct tgtcatcata gcaattacca 3153901 atattataaa gggctgatcc gatcaaacgg ggctgtcctt ccaataaagc aaggcgatac 3153961 gcgtcatcta aatgttcaag cgctttttca taatttctgt agtcaatgta gtttcctgat 3154021 atgacgaaat ggcattgaat tcttctgact ctgtaaaaat cgtgagcctt atacgtctcc 3154081 agcgcctgta cggcatggtt catggaaaag tgcgtctgct tcataatata aaagacttcc 3154141 gccactttaa aatgaaattc cgctctttca atttcatctt ctacaaacgc aagcatcttc 3154201 tcagctttcc gataaaagga tatagccgag atgtaattgt tctgttcaaa ttcgtacatt 3154261 cctctaaaca agtgaaaata atactcagat aatccggaga tgctgtcctg attgctttcc 3154321 agcgttttga tcaattcacg atattgaagc tgagattcct cgtgcaggtc aggctttaca 3154381 taatccagca taatttggtg ccggtagctg atcagctgat aatacaggag aagcagctga 3154441 tcctcttcca tctgttcgat atctagatca atttcttctt tcagttttac ggcatcagcc 3154501 acttgaaatg ctaaaatgtg cttataccac ttattgattt tcactcctac ttgagatgac 3154561 gggatctcgt acgcggccat gcccctccaa ccctttctat tttctaattg gttatatttt 3154621 atcataatgt atggctttgg aattaaattt tcttacaatg attccttctt tatgcctatc 3154681 cttatatatt tcggtttttc tacgtatttt ttgcactcgg attctaataa aaaagcttac 3154741 cggacagtgc cgataagctt ttgacttcaa attaaccgcc aatataagac atttccactt 3154801 tctttttgcc agatgctttt gatagcgtac gatcgactga atactgatcg atccgatttt 3154861 tccatactgt cccgatcatt tctgatagtt cgtcatcact taattcctgg cgaaccggag 3154921 ctctgaggtc aaatccgctt gaagcgaata agcaggtaaa cagctctcct ctcgcagaaa 3154981 gacgggctct gttgcaagat ccgcagaatg catcagatac agatgatatg acgccaattt 3155041 ctccggagcc gtccaagtag cggaatctgg aagccacttc gcctatataa ttaggcgcta 3155101 tcggctcaac cggcatgtgt ttattgatca aatctatgat ttccgccttt gtcatgacgt 3155161 ctttcttttc ccattggttg gtgttgccta cgtccataaa ttcaatgaat ctcaggatat 3155221 gccctttttc tttaaaataa cgggccatag gcagtatatc tttttcattg acgccctttt 3155281 gaacgaccat attgatttta acaccgagcc ccgcttgctt cgccgcttca atgccttcca 3155341 gcaccttgct gacagaaaca ccgcgcccgt ttatcttctt aaaacgctcg tcttctaaag 3155401 aatcaaggct gatcgtaacc cttttcagcc cagcctcctt gagcctctta gcataaacag 3155461 gcagcagtga tccgtttgtc gtcatcgcga tgtcacgaat acccggtatg cgggccagtt 3155521 ttttgattaa ttccggcata tcctttctca tgaggggctc tccgccggtc aagcggattt 3155581 tttcaacgcc aaatcttgtg acaaacaatg tcgcaagccg ttccagctcc tcaaatgaaa 3155641 gcagctcctc tttctttaaa aaaggataat ccgggccgaa taattcggcg ggcatacagt 3155701 acgtgcatcg gaagttgcag cggtctgtaa cagaaatgcg aaggtctctc agcggtctgt 3155761 ttcttttatc caacatctga cgcgactctg taatcatagc tacagcccct tcctactccc 3155821 tgattctctc agggtgtgta tatacattaa atgatccgtt tctgacaaat ccaatcgctg 3155881 tgatattcaa ttcttcagcc atttgaatcg caagctccgt cggggccgat ttggaaatga 3155941 caatcgacac gccgattttg gccgctttta acaggacctc tgatgagatt ctgccgctga 3156001 acacaatcag tttgtcgcgt acggacatcc cgtttagaag gcagtgtccg tatagtttat 3156061 caagtgcgtt gtgccgaccg atatctgtgc gcatcaacag aagcttctct gtgtcgcaaa 3156121 gcgccgcatt atggacgcct cccgtatcct gaaacgtccc gctcccttgc tgcatgtctt 3156181 tcataagcgc cagacatgcc tcaggcgata tcttgatttg gctgacagcc gtcttggctg 3156241 ttttgacatc ctgctgaaaa taaaaatgac ggccctttcc gcagcatgag ccgatcaccc 3156301 gtttcgtata atccttttga tccaatgtct cagggtgaac gaggtcgaca tatacaaaac 3156361 cgagactttc atctattgta aaccttttaa tttctttttg aaatcgtata acaccctctg 3156421 atgcgagaaa tccgatgaca agctcttcga tatgctcagg cgtacaaacg agcgtcacaa 3156481 attcactgcc attcagtatc actgtcaaag ggaattccgt caccatccgg tcttctactt 3156541 tgcttatttc cccttgttca tagcgccata catccctgac cgcagttact ttatcgttca 3156601 atgtctcttc ccctccgcaa tgttcctgcc tttatatttt ttcacactcc tcggattttg 3156661 tcgaattctg agacacaaaa agagccctct atataaaggg cttttacagg atgtgatgac 3156721 ggcggtgttt aggcaggacg cctaagcatt tagccgccgt tccttttata acacgtgagc 3156781 accaatgtgc attgacaacg aacgcggggt ttgtcgacac gctgagacac ctctgtataa 3156841 aggactctat gtttgattat gctgattctt tttcagaacc gtaaacagca caatagctgc 3156901 gatcaaggtg agaatgctga caaaaaagaa ggctgccagt tttagaagaa caccaagcaa 3156961 tataaatgca acggtggcta taagaaaaat cattccgaat aatttcatat gttcaacccc 3157021 tttttagggt atcattcccg cccaaactgt ttttaaacca ataaaaaagg cgcctggggg 3157081 agcgcctgat ctttaggttc cttactcagt aaatttttgt gcttcttttt cccaagcctg 3157141 ttcgaactca tccgcactgt tcgctgaaat atattctccg ccgccagcga cagctgcttg 3157201 tttcatctct tcattaccct tgacatcaaa gttgaagcca atgatgttta caatcgtatc 3157261 cacatttgat gcacggagct tttcgatttc cgccgcaggg tctccgccgc acgtttcttc 3157321 accgtcagtg attaaataca ccacgttttt cccgtctgcg tcaaatgctt caaattcttt 3157381 tcttgtgtct gcaagtgctt tggcaatcgg tgtccatcca gtcggcttga gctcactcaa 3157441 tgaattgtca aacagagacc cttcatatgg atgaaggccg taaatggttt ccgtcgtact 3157501 gcacgaaagg gctttaccgg acagtttatt gttccctgca tgcccgaaaa cgcgaagcat 3157561 aagatttgta tcctttggaa gaagttcggc aaaagatttt actgattttt tggcaatgtc 3157621 tattttgcgc tctcctcctg ttttttgaac catgcttccg cttccgtcaa acaaaacagc 3157681 tacatttgta tcagcctgtt tctcagcggc aaaagacggg gaggcaatgg aaacagtcaa 3157741 caatccaatg ataccggcag ccagcaattt tttcatatga ttacttcctt tctttttcat 3157801 attttccaac tatatgttgg attcttcttt atgctagaat acgaaaatgc aaaaagatat 3157861 aggacatgct gccttttgtg ctgctttcac gatctgtcca aaatcgcttg aaatgccgtt 3157921 catttttagc catttccgcc cagaaagcat aaacagcttg tgtgatcatt cattcttttt 3157981 tcgccttgat tatgacagaa aaacggaaat ctgctactat gctacaggca gacagctaat 3158041 tagttttgaa gtttttgtta catacaaaaa gaggctgacc atcaccagcc tcttttttct 3158101 tatttagata acattagtga ttgctgagtg aaaattttct caacatcttt ttgggtataa 3158161 gccgggaagt attcaccgcc gcctactttc gcaattgcgt tcagctggcc tttgtatccc 3158221 tctttataat caaagccgat cacattaaca gtgatattgt ctttttgcag ttcctttgct 3158281 gttttaatcg ggtttcctcc gcacgtttcc tcaccgtctg tcaacagata caccactttt 3158341 tccccttttg catcaagctg gtcaaaagaa gatttcgcct cgttcagcgc tttggcaatt 3158401 ggcgtccagc cagtcggccc aattgtattg agagaattga ggaagctttg ctcgttaaag 3158461 ctttggaagc cgtatacgtt gcgaatggct tcacatgact gaacttttcc ggaattttta 3158521 ttgtttcctt cagagccaaa cacgctcatt ttcacctgag ttccttctgg caatgagctc 3158581 gcaaactttg aaatttcttt tttggctgaa ttaaatttag atacaccatc tattcttttc 3158641 gccatacttc cgctggcatc aagcaagacc gccacgttcg ccggcgcttt agcctccgtt 3158701 tctgtctttt cagctgcaaa agcaggtgaa gttaatccaa aaagcaatcc tgtcatcatg 3158761 atcagtgaaa atcttttctt catgttcgta cccctttacc aatttgtttc tgcgtgcaga 3158821 tgttcaacgc tgaacataat ctatcgtaat caacaaaaac cgagaaataa atagggcggg 3158881 cttccccatt gctgttgttt acttttgcat agaaacctat gtttttatta gtgatttcca 3158941 cctaacgccc ctatgaaaag agaagattgt ccgcctttcg gctttcgtta tatgagtctg 3159001 tcgaagtctg tcgacaaatg tggatgactt taccacaatc tcaaagcctg aaatcaggaa 3159061 aaaaggactg atccttaaag acggtcagaa gctcctctaa accgtttcag ctactcttag 3159121 ataaaagata ttcaggaaca gaaaaagacg cccaatgagc gtctttttct actttttcgc 3159181 catatattta ttcaaaaacg catctgcctc agaaatttgt gtgccttggt aatagtactt 3159241 tacaatgtca tcaaccgttt tgccttcttt ggccataaaa ttcgctccgt attggctcat 3159301 ccccacaccg tggccaaatc ctctcgtcgt gactgtaatt gtgtctccat ttcgcttcca 3159361 ttcaaaatcg gcggagttga gacccaactt ttcacgtatg tctcttcctt tcagcgtctt 3159421 gccgttaatg acggcagttg cgacctggtg gcccggtgtc tcgccggtaa tcttccctac 3159481 tgcgctagat ccatccagct tgacgccaag cttttgctga aattctgccg ctgtaaaggt 3159541 tttcgttgcc ttatatttcg gagacttttt atcccatggg cttttgacgc tttttaaata 3159601 tgggatagca cttgtccaat aagcttctgc attctctgtg tagccgttgc ttgtggagaa 3159661 aaaggatgct tcaatcggct ggttgttgta cgttaagatt ttgccttgcg tactggctac 3159721 cgcatctgtg attttcttca gttttgtctc atagcttgtg ccccactgtt ttttcagctc 3159781 cgctttgctt ttatacacct ggaacatctg tgtatcatcc accagtgagc ctttaggagc 3159841 ttctaccgct gaatttgaca ccatcagtct gacaataaat gttctggcgg caagcgcctg 3159901 ggctttcagc gcttcaggtt taaaggttgc cggcatttcg gaggcgacga ctccaatcac 3159961 atactcttca agcggaatgt tttctacgga ttgatttgcg gttcgataga cgggaataga 3160021 aacaggtgat gctttcaatg tttctgctcc tttcgatgct ggtttcgtgc tgactgctgt 3160081 cttttctgat tctacgctgg cccccgcttc cttattatgc tggaatggta taaccaagag 3160141 tgtgggaacc aagagaatca atgcacatag tacggatagt gtgattgcga attgtttcat 3160201 attcagctgc ctcctgctcg ggattcgact ctagtctagt ctatgggcag ggacaagcta 3160261 atatgactct cgttttggac agaaacttta tttgtcattt acgtattctt ttttgctatt 3160321 ttgcgcataa tgatgataat acacaaaaaa taaaaaacca gtatgccaga gtgacatact 3160381 gattttcaag taagtttatg catttaagtc agaaacgact tctttattct cttgctcaga 3160441 agcagactca tcatttacac gttcgatgtc tgcgcccaga gcggcaagct tctgatggaa 3160501 atcaacgtaa ccgcggtcta agtgcttcaa ttcagtaaca cgtgtgtgac cttcagccac 3160561 taaccccgca agaatcagcg ctgcacctgc acgcaaatca gtcgctgcaa cttcagctcc 3160621 ctgaagctgt acaggaccgt taatgatgac agaacgtcct tcaatcttga tatcaccatt 3160681 catacggcgg aattcttccg catgcataaa acggttttca aaaacggttt ctgtaatcat 3160741 gcttgtgccg cttgcacgaa gcagaagcgc catcatttgt gactgcatat cagtcgggaa 3160801 gcccgggtga ggcattgttt tgatgtcaat cggtttaagc tctttcgggc cgatgacacg 3160861 cagaccttca ccttcatcct taattgttac acccatctct tccatttttg caattaaaga 3160921 ggtgaggtgc tcaggaaccg ctccttttac taatacgttt ccttcagtga ttgcagcagc 3160981 aaccataaat gtgcccgctt caatacggtc aggaataata tggtgtttta cgccgtgaag 3161041 cttttcgact ccttcaattt tgatggtgcc ggtgccagct ccgcggattt ttccgcccat 3161101 gccgttgata tagtttgcta aatcaacgat ttcgggttct tttgccacgt tttccagcgt 3161161 tgttgttcct tcagctagag cggctgccat aatcaggttc tctgtagctc ctacacttgg 3161221 gaagtccaga taaatttttg cgccttgcag tcggcctttt acttcagctt caatgaagcc 3161281 attaccgact ttgatttctg cgcccattgc ttcaaaacct tttaaatgct gatcaatcgg 3161341 tctggaacca attgcgcatc cgcccggaag tgcaactctt gcatgacctg tacgcgcaag 3161401 aagcggcccc atgacaagca cagacgcacg cattttacga acatattcaa aaggtgcttc 3161461 agtttgcaaa gcgtatgaag catttacagt cacttcatta ttttcaaaat gcacatctgc 3161521 tcctaaatga cgcaacactt cgttaattgt atatacatcg gagagcgtag gtacatcaca 3161581 aattacgctt ttttcttcac ttgctaataa agatgcagcg ataacaggta aaacggcatt 3161641 tttagcgcct tcaactttga ctgtgccgtt taacttctga ccgccgcgga cgatgatttt 3161701 ttccaaggta ttcccctccg cgtccctaaa ttctctatat taatattcag tcgtaacgat 3161761 tggtgtgcca accgtaacgg tatgttttcc gcccattcct gcacttctaa gtgcaatttg 3161821 caaattcatt ttatgtttcg aggtcataat gtactcttcc cactcatctg taaacgcaga 3161881 aatagaaacg aaatttggct caactacatg ttctactgat cttgcttgaa attcatttaa 3161941 taactgattt gctttttttt gcaaaacaat attcatatta tcatctaagt gaccatttag 3162001 acaagtaaaa ataactactt tttcttggaa tatcccaagt gtctcccgtt caaactgttc 3162061 atatgtatca ttccagctat ccggtgtctc tagactcatt tgctcatata ataaatacga 3162121 agttggattg tgttttttga gggttgtgac aagctgcagt ctaaaagaag tacgattttt 3162181 tttgtcagta tatgtgccaa ttgcctttat cattttatct tcccgtgcaa tcacccaatc 3162241 atattgacga tactcttgtt ttaaacgttg cactttttga taaaattctt tttcggtcag 3162301 tgacaagttt tgttttgcat gcaatgtcca cttatctatt gacacatctt gacgttccat 3162361 cccctctgcc atctgtgcta acggcgttaa ttcactcgca tgaatggtat ggaaaacagc 3162421 aatgacgaag cttaacatga cggaaatgat aatagcgtgg cttacttgtt ttttcttcat 3162481 gttcatctct cccccttatc cccagtttta ccggaggcaa gaggcgccat acgtaaaaat 3162541 cttcgtcaaa actcgagcta ttcgcttcaa cccgcttctc ccaaccattt aataatgttc 3162601 aaaacctatt aaaatagata gggaagctgc tgtgaataat tgaggtaatc taaaaagaaa 3162661 ttggcaacgg ccgttccaat ggcgattgtc agcaaaatca tcaggagtct tgcctgcacg 3162721 actttgcctt ttttgattaa cggatctata ttgacggctt gcaacgccca ccaagtcact 3162781 gctataaaaa tcaggtgaac gacaatgccg attgcagcct gctgtcccaa tacactcatc 3162841 tattacactc ctttctctgc gttcataccc tttcttatta tataagaagc acagataaag 3162901 atgatacatt ttatacagaa cggaataatc agccaaatct agggctaatc cccgcttaaa 3162961 gtgcgattct tttacatggt atactttatt ggaaaggagc tggcaaatgt gaatcattct 3163021 ttttttcagc ctgaaaagca atatggtgag gacctgccaa tttttgatca ggaatgggaa 3163081 gcaattgcat tctattatga ttatagacag tcacagattg aagaactgaa tgaattgtgt 3163141 cagtttttta acatttctct tacctatacg agagaaagcc ttgaagagct tgaaaacctc 3163201 tattttcaaa gtatacaaga acttttgctt gctgattgga atcttcctat tgaagaattc 3163261 gagaaaatga tcagtgttta tcttatagat tgtgtgattg cccgccatga agatgctgaa 3163321 tgggttgtaa aaccttatcc ctataaagac ggcgcttata cacttggctt tagaagacat 3163381 cgcaaatcgt ggcatacaat gaatgcctgt gatggtttat acctgcgtcc aaaagaggat 3163441 cgcccgttgc tgtcgctgtt tgattctctt gtgcgttcat aaaaaaatcc ttctcataaa 3163501 gagaaggatt ttttcttatt tccctgctac atccaatctg ttcaaagccc gctgtaacgc 3163561 aagctcagcc cgacgaatgt cagtatcatc tgattgagaa ttcaaacgct cctgcgcccg 3163621 ctggcgtgca gcttcagcgc gctctttatc gatgccttcc gctgtctcgg cagcctgggc 3163681 aaggatggtg acatgatcag gacggacttc tacaaaaccg ccgctgacgg caaccatttc 3163741 agtctgcccg tcttttttca gacggacagc gccgatttta agaggagcca cggttggaat 3163801 atggcctggc aaaataccga gatcgccgct ttcggctctc acactcacca tttcgatatc 3163861 cgcatcgtat actgggccgt cgggagtaac gatattgact ttaacggtct tcatgctttt 3163921 accctcctag gaccagatta aacttctaca cccatttctt ttgctttctc aacaacttct 3163981 tcgatacggc ctacaagacg gaatgcatct tctggaagat ggtcatattt accggctaag 3164041 atttctttga agccttgtac cgtctctttt acaggcacgt aagaaccttt ttgtccagtg 3164101 aactgttcag ccacgtggaa gttctgagaa aggaagaact ggatacgacg tgcgcggtga 3164161 acgacaagtt tgtcttcctc gcctaattca tccataccga gaatcgcaat gatatcctga 3164221 agctctttgt aacgctgaag cgttgactgt acttcacgcg caaccgcata gtgctcttct 3164281 ccaacaattt caggagcaag ggcgcgtgat gtagatgcca acggatcaac cgcagggtaa 3164341 atacccattt cagttaattt acgctcaagg tttgttgtcg catccaagtg agcgaacgtt 3164401 gtcgccggcg ccgggtcagt gtagtcatcg gcaggcacgt agatcgcctg gatagatgta 3164461 actgatccaa cgttcgtaga cgtgatacgc tcttggagct gacccatctc agttgcaagc 3164521 gtcggctgat aaccaaccgc tgaaggcata cggccaagaa gggctgaaac ctctgaaccc 3164581 gcttgtgtga aacggaaaat gttatcgatg aagaacagta cgtcctgtcc ttgtacatca 3164641 cggaagtgct cagccattgt aaggcctgtc aaagcaacac gcatacgtgc gcccggcggc 3164701 tcgttcattt gtccgaatac catggctgtt ttgttgatta cgccagagtc actcatttcg 3164761 tagaaaaggt cgttcccttc acgagtacgc tctcctacgc cggcgaatac agagataccg 3164821 ccgtgctctt gcgcgatgtt gttgattaat tcctggatta atacggtttt acctacaccg 3164881 gcaccaccga acaatccgat tttaccgccc ttaatgtaag gagcaagcaa atcaacaact 3164941 ttaatacctg tttcaagaat ttcaacttct gttgaaagct gatcgaatga aggcgcctgt 3165001 ctgtgaatcg gatccttttt cgcatccgca ggaaccggct cattcaaatc aatattttct 3165061 ccgagaacgt taaatacacg tccaagtgtt acatcaccaa ccggtactga gattggcgct 3165121 cctgtatcta cagcttccat accgcgctga acaccatctg tagatgccat tgcgattgta 3165181 cggactgtat catcacctaa atgaagagcg acctcaagcg ttaaatcaat acctacttcg 3165241 ttttcacttg cagctggctg tgaaatttta atcgcattat aaatttcagg caagtgaccg 3165301 tcttcaaaac gcacgtcgac gaccggtcct aatacctggc taacgcgtcc tttcttcatc 3165361 gctatccctc ctgacaaaat ctttctattc taaagcggct gctccgccga caatttccgt 3165421 aatttcttgt gtgatggctg cttggcgagc gcggttgtaa gaaagcgaaa gtgaatcgat 3165481 aagttccttc gcgttgtctg tcgcgttttt catcgccgtc attcttgcag cgtgctcact 3165541 tgctttactg tcaagaagcg caccgaagat taagctttct gcatattgag gaagcaaaac 3165601 ctccagaacc tcctcttcag atggttcaaa ttcataagac gccgttcttt ttccgccgcc 3165661 gctgcccaaa tcagataacg gcagaagttt tttctccgtt acttcttgag taatggcgct 3165721 gacaaaatgg ttataaacaa ggtgcaattc atcaaacgca ccgtctataa acatttgaat 3165781 cgtttgacgg gcaagatctt taatttctgt aaacgttact tcatctccaa gtcctgttaa 3165841 ctcggaaatg atcggaatct cccgtttctt aaagaaatca cggcccactc ttccgatggc 3165901 aatcaccgca tactcatcct tagactgatg acgttcttgc atggcctgat aagcactccg 3165961 taaaaccgaa ctgttaaaag cgccggcaag accgcggtca gacgtaatga caaggtatgc 3166021 cgtttttttc acttctctgc tgagaagcat cgggtgcttc acgttgccgg aaactcttcc 3166081 gacgtttgac acaacctctt ggattttatc catatatggc acaaatgatt ttgcattgtt 3166141 ttcagcacga ttcagcttag ccgcagatac catctgcatg gcttttgtaa tctgacttgt 3166201 ttttttcgtt gacgtgatcc ttgacttaat atcgcgtaat gaggccaaag atttcaccac 3166261 cttttctctt catctgcgta aaaagagaga aaaagagaac ctttttctct catcagcatt 3166321 cgagttagtt gcttggtgca aatgtgcgtt tgaagccttc gattgcagct ttgaagtctt 3166381 catcagcagg aaggtttcct gttttcgcaa ttccgtcaag caggtcttta tggttttggt 3166441 caaggtacat gtagtactct tcttcaaaac gtctgatatc cgccacagga atatcatcga 3166501 gatatccttt tgtcagcgca taaagaatag ctacttgctt ttcaaccgga agcggcttgt 3166561 tcagatcctg cttcagcact tcaactgtac gcgcaccgcg gttcagtttt gcctgagtcg 3166621 cttggtcgag gtcagaaccg aattgagcga atgcttccag ctcacggtat gacgcaaggt 3166681 caagacgcaa agtacctgat acttttttca tcgctttgat ttgcgctgag ccgccgacac 3166741 gggatacaga caatccggca ttgatcgctg gacgtacgcc tgagaagaac aaatcagatt 3166801 gcaggaagat ctgtccgtcg gtgatggaaa tgacgttcgt cggaatataa gcagagatat 3166861 ctccggcttg tgtttctacg aacggcagag ctgtaattga tcctgcgcct ttcgcgtcgc 3166921 taagctttgc tgcacgctca agcagacggg aatgaagata gaatacatcc ccagggaacg 3166981 cttcacggcc tggcggacgg cgaagaagca aggacagctc acggtaagcg gccgcttgtt 3167041 tagaaagatc atcgtataca acaagaacgt gcttgccgtt gtacataaat tcttctgcca 3167101 ttgtaacccc agcatacggt gccaggtaca gaagcggtgc cggctgtgac gcagacgccg 3167161 ttacaacaat tgtataatca agcgcgccgt gtttacgcaa tgtttctact acgccgcgga 3167221 ctgttgattc tttttggccg atcgcaacat atacacagat catgtcttgg tctttttggt 3167281 tcaggatcgc atcgatcgca acagatgttt tacctgtttg acggtcaccg atgatcagct 3167341 cacgctggcc gcggccgatt ggaatcagtg catcgatcgc tttgataccg gtttgaagcg 3167401 gttcatgaac ggatttacgg tccataacgc ctggtgcagg gctttcgatc ggacgagttt 3167461 tgcttgtcag aatcgggcct agtccgtcaa ccggctggcc tagcgggttt acaatacggc 3167521 cgattaactc ttcaccaaca ggaacctcca tgatgcggcc tgttcttttt acttcgtctc 3167581 cctcacggat ctcactgaaa ggtcctaaga tgacgatacc tacgtttgat tcctcaaggt 3167641 tttgagccat acccaaaaca ccgtttgaaa attcgacaag ttcaccggcc atacagttgt 3167701 caaggccgtg cacacgtgca ataccgtcac cgacttggat gactgtacct acgtcttgaa 3167761 cttcaatatc agattgataa ttttgtattt gctgttttat cagcgtgcta atctcttcag 3167821 ctttgatgct cacttaggtt tcaccccttc tatcgatttt ccccggctaa ttgacgttca 3167881 atgcgctgaa gcttcccgct tacgctgccg tcataaatcc ggtttccaat gcggacttta 3167941 ataccgccta ttaaatccgt ctgcacttca tttctgattc tcagtgaagc gactccggct 3168001 ttttttgcaa acacttgtga taatggtaac atttctgcat ccgtcagcgg tttcactgaa 3168061 tatacgattg cgtcttctgt ttgacgggcc acatttgcga gtttgataaa ctcatctgtg 3168121 agctcaggga caatcgcggc acgatggcgg tcaatcaaaa gaaaaatcgt attgagtacg 3168181 gactgtgaca aagagccaaa tgcattttga atcagctctt ttttcttcgc agccggcacc 3168241 ttcggatggt tcaacacatc attaagcgct ttttcatttt gaaatacttg ttttacaaca 3168301 attagctctt cttctacttg attcagctga gcggactcat tggctatatc aaaaagagct 3168361 gatgcatatc gtttagagac agctgatcca ctcatcggct ttctcctacc tctttaagat 3168421 agtcctggat caatttctct tgcgcttgtt catccagttc tttttcgatc actttcgacg 3168481 caatcatgac agaaagagac gctacttgct cacggagagc agaaaccgcc tgttcctttt 3168541 ccttcacgat ttcagttctt gctgcttctt tcagacgttc agattctgca cgtgcagcct 3168601 gaataatctc ttctttttgc ttctctccca gtttctttgc gttttcgata agagtttggg 3168661 attcctgtct tgcttctttt aaaagaacgc gctgctcttc aatcagctgc tgcgcttctt 3168721 tatttttttc ttcagcagac gtaatttctc cagcgatgtg gtcttcacgc tgtttcatta 3168781 tgtttaatag cggccctaaa gcgtatttct tcagaagcgc taataagatt aacatagcta 3168841 acagttggaa caggatatct ccgccgttaa acgacaatcc tagttcaagt ggtaattgag 3168901 acatctacta cggcaactcc cttctgcagg tttttctttg ctgatccagc agccgcactt 3168961 gtctcttttc agccggcaag gcgggatgct tatcagacat aaagcaatgg cgaaggttct 3169021 cttggaatga tcttcgccat ttttagttca tataaggctt ttatgcttag ccaaagaacg 3169081 ctaagaatgc gataacgaca gcgataatag gaagggcttc aactaatgcg atacccatga 3169141 acataagagt tctcagttct ttacctgctt ccggctgacg ggcaatcccc tctaccgtac 3169201 gtgaaacaat caaaccgtta ccaatacctg caccaagtgc gcctaaacca attgcaatcg 3169261 cagctgctat taaattcatg aaaaagttcc tcctttaaaa tgttatccgt ttggatataa 3169321 tgttttaatg atcatgactg attttatgag acatgtacac catcgtcagc attgtaaaga 3169381 taaatgcctg gatagcacca ataaataaac tgaatgcttg ccatgccagc atcggcagaa 3169441 tggcaccgat tgtaccgaca agaccgagag ccacgctttg cgaataatgg cttgttgcta 3169501 atcccgcaag caggccgaga agaatctcac cggcgaagat gttaccatac agccgcaaac 3169561 ctagagtcag cgtattcgca aactcttcga tgattttcat cgggagcatg aatggaacag 3169621 gtcttaaata gtctttggaa tattccttga gccctttcat cttcacacca tagtagtggg 3169681 ttaaagcaac aaccatcacg gctagcgtta atgtaatggc aggatcggct gtcggagact 3169741 tccaccagag ctcatgtccg attgtaatag agaacggcag ccccagcata ttcgacacaa 3169801 atatgtacat cagcaatgtg acaccaagtg ccaagaagtt agcccctgtt tttaaatcca 3169861 ttgtactgcc aataatattg cggacgaaat caacaatcca ttccataaag ttctgggctt 3169921 ttccgggacg gatcgaaagc gttcttgtcg tcaatatagc aatcaataaa acaatcacac 3169981 tcgccacagt aatcatcaga atgtttgtca gattaaaagt aagacctaga aattctatag 3170041 ttctgtaacc atgattcaaa gggttttcac ctctcttcca ttgatgaacg tttaagctgg 3170101 ataaaggaat ctatcataat gacagggtat attgtcatta atccaataac tgtacttgcc 3170161 atatgaaagt attcgggatt tttataggca acagccacag caagaatcgc attgcaccac 3170221 cgcgctgcgc tcccgagaga tcgtatggac tttcctttct ctacagctct gtcaaaagca 3170281 ttcattcttc tgacgagcag taaaaaatta aacaaactga aaacagttcc cagaataagg 3170341 cctaaaaaaa cggttttata cgctgttaaa ccataaccca gtacatacac tgccaaaatg 3170401 aacaataaat atttgcgttg tctgctaaat gtaagcttgg gatcgtccat caattatctg 3170461 tctcctgatg aaaaaataat gtatagcttg gatacggcaa aaatcagcgg ttaaccctta 3170521 gtagaagacc ttttttgacc ggcaaaacgg gcctgttcga aaaaatcatt catccgcaag 3170581 ccttgcaggg atgctgtttc attcgcttaa ataaatcctc ataatacggg tttgctgaga 3170641 ggatttacat tgaggatgag gactataatg aaagctatga aaaccttctc ataataccct 3170701 cgtttagcat acaatagccc ctaacatgtg tcaatctgtt taaagttaaa aaacttttta 3170761 tactttacgt ctccacagaa tgttcacatt ttcacctata attgtataca gattcaccga 3170821 atagcaaaaa actggataaa aaaatgaaac ccccttttgg ggatttcatt ttttattttg 3170881 ttccaaacat gcggtcaccc gcatctccga gacctggaac aatatatcct ttttcattta 3170941 atttttcatc tagcgccgca atgtaaatat caacgtccga atgatgcttc tgcaattctt 3171001 ccacaccctc cggcgctgct acaagacaca tgaaacggat atttttcgca ccgcgttttt 3171061 taaggctgtg aatggcttca actgcggaac cgcctgtagc gagcatcggg tcaaccacga 3171121 tgaattcacg ctcttccaca tcagaaggaa gcttgacata gtattccacg ggttttaagg 3171181 tttctggatc acggtaaagg ccgacatgtc ccacttttgc cgcaggaatc agctttaaaa 3171241 tgccgtcaac cattcccaat cctgctctga ggataggaac cactccgagt tttttccctg 3171301 agatgacttt cgatttcgca gcctgaaccg gtgtattgat atccacttct tccagaggaa 3171361 gatcgcgggt aatttcaaat gccatgagtg tagccacttc atctactaac tctctaaaat 3171421 ccttcgtacc tgtattttca ttccgtatat atgtcagctt gtgctgaatt aaaggatgat 3171481 caaatacata aacctttccc atactgtgtt tcagctcctt ttttattgtc ccatcaacaa 3171541 ttacacactt ctattgattc tacaaaaaaa gacattgagt ttcaagaaca tcgtcaaaaa 3171601 acccgccggg cataagccca agcgggtttt aggatcttaa taatctaatt ctttatataa 3171661 aggaaattta tcagtcagag cagctacacg ctgtcttgct tcttcaagtt ttccttcatc 3171721 ttcgtggttt ttcaatgcaa gcgcaatgat agcaccgact tcttctaatg cgtctccgtc 3171781 aaaaccgcgg ctggttacag cagctgtacc aagacggatg ccgcttgtta cgaaaggttt 3171841 ttcaggatca tatggaatcg cgtttttgtt agacgtaata ccaatttcat caagtacatg 3171901 ctccgcaacc ttaccagtca gtccgagcga acgaaggtca acaaggataa ggtggttgtc 3171961 tgttccgcct gaaacgagct ggatgccctc tttcgttaag gcttcagcca gacgtttcgc 3172021 gtttgaaatg acgttttgtg catatgtttt gaaatcgtcc tgcaatactt caccgaatga 3172081 aacagctttt gcggcaataa cgtgcatcag agggccgcct tgaattccag ggaagatcga 3172141 tttatcaatt ttcttgccaa actcttcacg gcaaaggatc ataccgccgc gaggaccgcg 3172201 aagtgtttta tgtgttgttg ttgtaacgaa atcagcgtaa ggaaccgggt ttggatgaag 3172261 gcctgccgca acaagtcctg cgatatgtgc catatccacc atgaagtaag cgccgacttc 3172321 atcagcaatt tcacggaatt tcttaaagtc gattgtacga ggatacgcac ttgctcctgc 3172381 tacgataagc ttcggtttat gagcgagggc tttttcacgc acgtcatcgt aatcaatata 3172441 ttgagtttct ttatctacgc cgtactcaac aaagttatat tgaacaccgc tgaagttgac 3172501 tgggcttccg tgtgttaaat ggccgccgtg ggagaggttc atcccaagta cagtatcgcc 3172561 ttgctccaaa atcgtgaagt acactgccat gtttgcttgt gcgcctgaat gaggctgaac 3172621 gtttacatgc tccgctccaa agatttcctt cgcgcggtca cgggcgatat cttcaacgac 3172681 atcgacgtgc tcgcatccgc cgtagtagcg tttgcccgga tatccttctg cgtacttatt 3172741 tgtcaaaaca gatccttgtg cttccataac cgcttcactt acaaagttct cagaagcaat 3172801 caattcgatc ttagtctgtt ggcgttcacg ctcattttta atggcgttaa acacttgttc 3172861 gtcttgcgca ggtaaatgtt tcatcagcga gatcctctcc tatccgtatc ctgttctttg 3172921 tttttaccat cactattgta catggttttt aaggccgatg taaaagatta tttttaaaaa 3172981 atctaaattt ttattggtaa aaacgaatat taataactta aatttaattt aaagttcgga 3173041 atttatttca ctatcttaaa ataaaagaaa agactggcta tgcagtcctt tcattcgcac 3173101 tcataaaccg cccgcactcc gccgattagt ttcggccgtg tacgcgccaa tgtcacatga 3173161 gctgaaccga ggctgttttg agagacacgc acagggacag ccaccggttt cagatgcatg 3173221 ccgataaacg tatcgcctat atcaattccg gcgtcagcct gaatggtttc aacaagaaca 3173281 ggagacttca tctgcttaaa cgcataagac gccatcgctc cgcccgcttt tggaacgggc 3173341 acggcagaaa cggttggaag cctgaacagc ttggctgttt ctgcttcgac gacaagcgct 3173401 ctgtttaaat gctcgcagca ttgaaacgcc agatggattc ccgttttttc ccggagctca 3173461 gcaagtccgc tgtagatgct ttcagcgata tctacactgc ccgatgtgcc gatccggctg 3173521 ccggccactt cgctcgtgct gcatccaagg acgaagagct gatcttgttt caattccgct 3173581 tggtcctgaa actcagacag catcgtcttc cacgtttgtt tcaactcatt cattaaacag 3173641 cacccctaca ggtttttctc ttcataatcg gagatttttc caatacgcgt ttggtgtctt 3173701 cccccggtaa actcagtagt cagccagatt tttgcgattt cccgagccaa accaggtccg 3173761 atcacccgtt cacccatcgc aaggatgttt gtgtcattat gctccctcgt cgccttcgcg 3173821 ctgaaggtat cgtgcgccag cgcgcagcga atccctttta ctttattagc ggaaatgctc 3173881 atgccgatgc ctgtcccgca aattaaaatg cctctgtcaa cttcgccgct aaccactttt 3173941 tcggccaccg gaaaagcata atccggataa tcgacagagc cgctgccgca gtcacagccc 3174001 atatcaatat attcaatttg caattcgtcc attaactctt tgatttcatt tcgaatgtga 3174061 acgccgccat gatccgatgc aatggctact ttcatctgct tttcctccca gcgtgtgtga 3174121 tgcggcccgc ccgctttatt gaccgcgcag cctgtccgct ctttgattca caccatatga 3174181 tgtgcttttc actatattct actccttcac gcaggatttg caaatgacct gtttgcagat 3174241 tttctgacaa cttatctacg gtcttttttc agctgttttg ccagctgccg aagaagctct 3174301 tcaagctcat ctcgcgtttg tttatagatg tcaattgagc cgccgaacgg atcgaggaca 3174361 tcaccatggc tgcctgtgac atattctttt aacgtaaaca ctttatcacg ataacgtcca 3174421 aattggctgg caatgatctg tttgtgctga tgggtcatag ccagaaccaa atcagccgat 3174481 tccataagtt cttcagttaa tggagaagac acatgattaa gggcaatgtg tttttcaaac 3174541 agcgcttcga ctgcatgagg cgtcgctttc ccattaggtg aagcaaacac gcctgccgag 3174601 cggacattga cattcagccc ttccctttct gcaattgatt taaaaagcgc ctcagccatt 3174661 gggctgcggc acgtatttcc agtacagaca aaaataatat ccatgtcagt caccccttat 3174721 ttttctctat tatatatgaa gaaaaaagaa acggcgactt cgtttctttt attggtatat 3174781 taaattggca aaagcagctt taatccaaac acgattaata tgatgccccc gagcgcttcg 3174841 ctgtatgtgc caagccatga ctgcacttgt tttccgacca gcaggcccag ccatgtcaac 3174901 atcatgctga acagcccgaa cagggtaatt gtgaggagcg gatgcgagcc gtatatcccc 3174961 aagctcaagc cgacggaaaa gctgtcaagg ctgacgccga tggcaaacag caataagccc 3175021 ggccctgccg gtgacatgaa tcgttcttct gactgtttaa aagaggccat aagcatttga 3175081 accccaagaa caaaaagcag cgccccaccg atataaaccg ctaacacgcc gaggagccct 3175141 gacagcatgt taccggccgc catccctgcg agaggcatga tgacgtgaaa gaggccgatg 3175201 atgaaaccaa tatagaatat ctgcttcttt ctaagtttga ccatgcccat tccaaggccg 3175261 acagaaaaag catccatccc taaagcaaac gccatgatgc ttaatgtaat cagttcgcct 3175321 ataaacaaat ccgacataca taaataaccc ccttggacac gccccgcttt tttagcctat 3175381 gcgtgtccaa aaagggttag aacatctgac tgctttcagc gaatcactct tcctccggcg 3175441 gctttcatca gcctgttcat aatagcaaga ccgacacctg tatccggaaa ggattccgct 3175501 ataatgaaat ccaccttatt ctcatcaaag ctgcgcaaag catcatacag ccctgccgca 3175561 acagtctcaa gctgagcccg tcttccgcag ctcttcacat aatcagcgga ataaacgccc 3175621 gctttttctt ctgtcgtcag gacaccgacc cgtcttccac cctgttgata ttcttgaatg 3175681 aggtgctgaa tgcgctctgg gctgccttcg caaatggcaa gaggcgctgt cggcgcataa 3175741 tgtgtatatt tcatccctgg agaaatcggc ttctcgtttt ggtcgctgag ccctttatcc 3175801 acatggatcg gcccgatcac cgcttcaatt tgttccttcg taatgccgcc aggacgcaag 3175861 agaacaggga tgtcgtccgc acatgaaagc acagttgatt cgaccccgat tccggtaggg 3175921 cctccatcca caataccggc tatgcggcca tccaagtcgt gagccacatg ctccgctttt 3175981 gtgggacttg gcttgcctga tagattggcg ctcggtgctg caatcggcag tcccgattcg 3176041 cgaatcaatg caagggcaag cggatgatcc ggcattctaa tggcaaccgt ttcaagacct 3176101 gccgttacac gaggtgaaag cgcatcaggt ttgcaaggca gaatgagcgt aagtgctccc 3176161 ggccaaaacc gtttcatcaa tgttttcgcc ttttccggcg ccgggcccgt taaatcctca 3176221 agctggctga tatccgcaat gtggacaatc aggggattat cgctcggccg ccctttcgcc 3176281 tcatatattt ttttgacggc atccgtattt tttgcgtttg cgcctaggcc atatactgtt 3176341 tctgtcggaa aggcaacgac ctcattttct cggagcaaag cggctgcttg tgcaatttgt 3176401 ggatcatttg tggataactc gtcagttaca tccacaaacc atcttttcgt tttcatttct 3176461 gaccaaactc cttattcaca acaataaaac gattgtttta cgcgtgtaat ccttttgaaa 3176521 gtataaaaga tgtcctgtaa taaaacaagc gttatccaca aattgtggac aacgctaata 3176581 aagaagtgga taagtatgtg tataaactgc acttatccag acgctttttt catcaaaacg 3176641 gctccttctg tttgccgcga ttcacagaag tgatcagaag aaaacagctc ctccggtaca 3176701 ctctcagctc tttcaaaacc catggccgtc agaaagtccg cagaggaatg ctgatttgct 3176761 actaggtaca cggttttgat ctgatgcttt tcgcacagca cctccatgct ttgaaaaagc 3176821 gtgacgatgt ggccttggtg aagcttgtcc gatatgacaa gtgatcgcag cagcccctgg 3176881 tcacagctta ttttttcaat accgaggcat ccggcaatgt ttttctcact gtcctccagc 3176941 ataagaaatt gagtgaagcc ttctttcacg ccttcatagc tggtttttgc ctgttttaaa 3177001 aatgcctcga gcacatctcc gtctttttcc cttgccaccc gcagttgata aaacatccgt 3177061 tcaccccgtt tttgcgttct ttcttccaat ctatgaggca aatctatttt tagaccagat 3177121 gattaggaaa aaaggtcgga aatccattcg actaaaaaga atttcacttc tgtgccgtct 3177181 tctttttctt cgttctcttc ttttttggct ttttccgctt tagcggttac gtcctcaagc 3177241 actttttcag tctgcttttt tgaggcttct ttatcttctt gttctttgac ggcttccccg 3177301 ttagaaaaat caagaaagca gaggggcggg aacagcacac accaccagtt ggcgccgtct 3177361 ccgtttccaa gcgtaatcaa aatcgcttca tactcaccag cgggatatac catgttgccg 3177421 taaagctttg tcggaaacga gattttgtca aaatcaacgg atatcgactg attcgctcct 3177481 tctttctcca ttgtttcctt tgcaattgct ttgatttcag gcagctttga acgaatcacg 3177541 cgacgcgctt cttcaataga agtaatatcc tttacccaag ttgtgatttc tttattcacc 3177601 gcgtctctta tatgacgttt taattgctgg tcttgatcac tatcgctgtt tgccagtatt 3177661 ctcaaacgaa tcgcctgatc aggtatgacc accggctgat tttccgattt ttgtgccgtc 3177721 tcttcttttg ccagccctac gagcgctccg gataataaaa gaaagatata tatacaaatg 3177781 attactgttt ttttcatcgg tccccaccgt tcctctccgt gctttgtttc tagccctatt 3177841 atggacaagg agagcctggg ataaacgtgc agggtgaaaa aaatctagca agctgttaat 3177901 cttatttatg gtacgatagt gttttaggag gtttaagatg aaatacaatt atacagtgct 3177961 gttatcagca ttcacgatgt ccgttcttta ttcagtaatt tatattcatt catttatcat 3178021 tgccgctctc atcacaatgg cattttattt tctgtttcct tatttgatct tcgcactgcc 3178081 gcttcaaatc atgatgaata aaaagccgaa acgtttcagc cctttgtatc tgctgtatta 3178141 ccttgccgct gcttttattg ccaacgcgat cattttcggc atgcttcagc cttcgggaca 3178201 atctctgttt caaaatacag ccttttatct tttcgctgta ttaacagctc ttatctattg 3178261 gatatgggat tctgttttac tgcaaaaaaa ggaagcctaa gaggcttcct tttttattaa 3178321 aacaaaatcg tcagtaaata acatagaatg gaaggtatcg ccgcaacaaa gaaagcggcc 3178381 gccattttca tgcgagatgt acggccttct ttggtttctg aatggtagtt tgcccgctga 3178441 tcgcttccgc ttacagccaa acccgatgta atgatcgcga gccccactaa aacgagagac 3178501 gcaacgccaa aaatcgcttc atatgaaaga gcctgcggaa aaatggtgcc aatcatgctc 3178561 tcaatcgcaa tgagcaggat tcctgctgtc agggcctttt tcatgtttac atcccctttg 3178621 ctggtgttaa acagcttgat ccattcactc gccagcaagc tgcttattta tttttatgaa 3178681 tcagagcgca tatggttctg tcttttccat taatatcttt cagcacttcc acttccgccc 3178741 ccttaaacgc cttgaggatc aggtctttga ccgccgctcc ctgtttccag ccgatttcaa 3178801 aaacgacaaa tactttatcc ttcataacaa gcggaatgtc ttccataaac cgcttataaa 3178861 atttcagccc gtctccgcca tcggtgagtg cgtgcagcgg ctcatgaaaa cggacaattt 3178921 ccgataaatc agccatttct tcctctgaaa tatatggcgg gtttgagaca atgatatccg 3178981 ctttttttcc cgccttaata aaaggctcaa gcagatcgcc ctgataaaag cgcacattcg 3179041 ctccgagttt ttctgcattg gcagaggcga cttgcagcgc ctctttcgaa atatcgaccg 3179101 ccgacacaga aaagctttgg ttttcaagcg caagcgtgac ggctattgcg ccgctccctg 3179161 taccaacgtc aacaacttcg agcttgccgt cttcagaaaa aacactccga tatttttcaa 3179221 gcaaatgaaa gacaacttct tcagtttccg gccgcgggat cagcacatca tcattcacca 3179281 taaattcccg tccataaaaa aactcttttc ctataatgta ttgaaccggc acgccctctt 3179341 tatgcatctc aacgtgacgc ttaaagcgat acagttcgtc ttcaccaatc ggttcctgta 3179401 agcttgcgag cagcttgctt ctctccattc cggtatcata aagcaatagg agctcggccg 3179461 cattttcttc tcttcccgct tcggttaaat aagaagaagc ccatttcagg gcttcgaata 3179521 tcgtcttcat cttaaccttc cgactgctga agcttgcttg cctgatcttc aacaatcagc 3179581 gcttcaacca cttcgtcaag ttttccttca agaatctgat caagcttttg aatcgtcaaa 3179641 ccgattctgt gatccgtcac acggttttgc gggaagttgt atgtgcggat acgttcagag 3179701 cggtcaccag atccgactgc tgatttccgt gtttgatcat attcagcctg ggcttcctgc 3179761 tgaaatttat catagattct ggcacggaga accttcattg ctttttcttt gttcttaatt 3179821 tgagattttt catcctggca tgatacaaca acacctgtcg gcaagtgagt cagacgaacc 3179881 gcagacattg ttgtgttaac gctttgtccg cccggtccgc ttgaagcaaa tgtatcgaca 3179941 cggatatcct tctcatggat gtcgacctct acctcttctg cctcaggaag acatgccact 3180001 gttgcagtgg atgtatggat gcgtccgcct gattctgttt ccggaacacg ctgtacgcgg 3180061 tgggcgccgt tttcatattt gagtttagaa tacgcgccgc ttcctgtaat cataaagatg 3180121 atctctttgt agccgcccgt tccggttaca ttcgcttcca tgacctctgt tttccagccc 3180181 tgaagctcag cataacggga atacattctg tacagattgc ccgcgaataa agcggcttcc 3180241 tcgcctcccg cagccccgcg gatctccatg ataacgtttt tgtcgtcatt aggatctttc 3180301 gggatcagga gcaccttcag ccgttctgac agtgtttccg tttccttctg aagttcagaa 3180361 atctcttcct tcaccatgtc gcgcatctca gcatccagct tctcttcaag catcgctttt 3180421 gcatcagcca gctgttctga cgcatctctg tattgtctat atacgtcaac tgtttcttgt 3180481 atatcagatt gctcttttga atattctctt agctttttcg gatcgttgac tacttctgga 3180541 tcgctcaaaa gctcatttaa tttctcgtat cgttcttcaa ttgattttaa acggtctaac 3180601 acggtcttca cctctgtttt cctgtgcgta acattctcat tatagtatag tgattaaccc 3180661 cagtcaaaag catttcaatc ccagctggaa aagctccctc tgctatactg gaattcgagg 3180721 agggatgatg ttgctgaaat ccatacatca tattgcaatc atatgttcag attacgaaaa 3180781 gtcgaaagct ttctacgtac ataagcttgg ttttcaggtg attcaagaaa cgtaccgcga 3180841 agagcgcggc tcctataagc ttgatttgtc gcttaacggc tcgtatgtca ttgagctgtt 3180901 ctcgtttccc gatccgcccg aacgacaaac ccggcctgaa gccgcaggcc tgcgccacct 3180961 cgcctttaca gtcggcagct tggataaagc tgttcaagag cttcatgaaa aaggaatcga 3181021 aacagagcca atcagaacag atccgctgac cggcaagcgt ttcaccttct tttttgatcc 3181081 tgaccagctt ccattagaac tgtatgaaca ataacagttt ttgaagaaaa aaaggagata 3181141 cccactttct ttgccgaatc ttttcttgtt ttgtctaacg ggaagggaac cgcattctat 3181201 ggtcgaatac ctagcttaaa aggaggtatg ggatcatgaa tacaaatatg gtagcaagtg 3181261 aactcggcgt ctccgcaaag acggtgcagc ggtgggtgaa gcagctgaat cttccggccg 3181321 aacgcaatga gctcggacac tattcgttca cggcagaaga cgtgaaggtt ctaaaatccg 3181381 ttcaaaaaca aatctctgaa ggcacggcga ttcaggatat tcatctgccg aaaagcgcta 3181441 aaaagcgcac aggcttcctt gtccaaaaaa caagtagcga cacagaacga agaatcgagc 3181501 agcttgaaca aaagctggac acccttttac agcaaaggca ggacgaaagc gaattgatgg 3181561 caaggatgtc ggaactggaa cgccagctga aacaaaaagc cgatgaaggt gtatcttacc 3181621 agctgcttca gcaccgcaga gaaatcgatg atattcttgc agatctgcaa tcactgacct 3181681 cacaaatgaa agaattcacc gctcattcga tccccgagac tgctgctgct tctgaaaaaa 3181741 ccaaaacaag aaaaaaaccg ctgctgtcac tgttcaaatt tcaaacctaa agcaaaaagc 3181801 tcccttaaag ggagcttttt ttgttacgca gtaagcgcga taatgattgg aagtgaaatc 3181861 aatgacagaa tcgcactgac cacaaacgca gttgcagttt cttcttcttg tttctcgaaa 3181921 cgagtcgcaa tcatggctgc aacggcagaa ccagggaatg caacaagaag gattgctttt 3181981 gttgtttggt cagctggaag tccgatagca agagcaatca ggaacattaa cgcaggctga 3182041 accgcaactt ttagtaacgc aataccgata gccggcatac tgagtttaat tttacgaata 3182101 ccaacggtaa caccaacagc gaagagagca acaccagatg ttgtgcttcc aagctgatca 3182161 agcattttaa cacccagctc aggaagagtg aaattgaaaa ccagcaccaa gatcatactg 3182221 attaacggag cagctgcaag cggctcacaa agaccatgca ggattgattt tcctgtcatc 3182281 ttccagaagc tgtcgccact ctcttcgttt ttcttagaag actcaccaac agtagcgata 3182341 atgatcgcga gcggatcaag aatcgcgtta accacgatac ctgtgaccgc gatcggaatc 3182401 gcaacttcat tcgctccgaa taagcttccc aataccggga tacccataaa tgcgaatgtc 3182461 ggctgtgcag agttcaaaga aaatacagat gagttcgtta aatcatactt gaatataaat 3182521 ctgcaaacca aaagaatgat gatatagaaa ccaacaatcc caataattaa agaaatcatt 3182581 aaaggtactt gtgataaaaa ttcacttctg gaagttgtca aaataccagc gataaagtga 3182641 gctggaagtg cgtatttcgt tactaacgta cttacccctt ttgccgactt ggcatcataa 3182701 cttccaaaat gtcctgcaaa ccaacccagc acgataacaa agaagatcgg cgccaggagg 3182761 attaagatat ctaagatgct caaaatattc tcctccaaat cctatgtccg tatactttag 3182821 ctttacaaaa agctttccct cggacagaaa aatttactcg ctaattattt cgcgatgact 3182881 tttttgtatt caggtgtcca cattgcatca agtaccgctt gtttcacatc ttcaggctga 3182941 cgatttgcca cgccgtcttt aattgctgct tcagcaacgg caatcgcaac ttggatagaa 3183001 acctcttgaa gcttatcaat gcttggaagc aatcctgctc caggtgtttc aagatcaacc 3183061 atttcagcaa tcgcatcagc agttgcagca aacatagcag gtgtaatgat acgcgcttca 3183121 gctacaattg aaccaagtcc aagaccaggg aacgcgaatg cgttgttaga ttgtccgatt 3183181 tcataagaaa caccgttgta ttctacattg tcaaatgggc ttcctgttgc aataagcact 3183241 tttccgtcag tccatttgaa cagatcttca ggaacagctt cagcaaggtg agtcgggtta 3183301 gacatcggca tgataaccgg acggtctacg tgagatgcca tttcttttac aatttcctct 3183361 gtgaatgcac ctgaaacccc tgaagtacca atcaagattg ttggtttcgc ttgacgaaca 3183421 acttcatcga atggaatttg acctttttca tcgcgcttcc agtctttcac ttcatccgca 3183481 ttgcgaaggt aaggtttttg gaaatcaagg atgccttcga tgtcttcagt cagcaagcct 3183541 ctgtaatcaa gtgtgtagaa acgtttgtta gcttcttctt cagataatcc ggctagcacc 3183601 attgtgtcac ggatttggtc agcaataccg ataccagcag aaccagcacc gaagataaca 3183661 acacgctgat ctttaataga agcgccggtt ttcttcatag cggcaagcac acctgcaagt 3183721 gtaatcgcgc cagtaccttg aatatcatca ttaaatgtca ggatttcatg attgtatttt 3183781 ttcatgatgt tgcgtgcatt tttgttgcca aggtcttccc agtgaagaag cgctttaggg 3183841 aagaatttca atgcagcttt tacataagcg tcaatgaaag cttcgtagcg ttcaccttga 3183901 acacgttcat gcttgttacc aatatataaa ggatcgttta gaagtttttc gttgttcgta 3183961 ccgacatcaa gcacaaccgg gataacacgg ctagggtcaa taccagctgc agcagtgtag 3184021 acagccaatt taccgattgc aatattaata ccgcctacac cccagtcacc gataccgaga 3184081 atgctttcgg agtcagtagc aacgataaga tcaatatcgc ctgctgtcgc atgaaggttt 3184141 tcaaacgctt tttcaatacc gtcaatgtta tcgattgaca agtagattcc ttgaggtctt 3184201 ctatattcat ggctgtattc ctgaatcgct tcaccaactg ttggcgtgta cacaacagga 3184261 agcatttcgc gaagatggtt tttcagcaat ttatagaaaa gaacttcgtt acggtttgca 3184321 agatcactta agtaaacatt ttgacgaagg cggtcaggct gcgcttggaa ttgctcgtac 3184381 gcgcgttgtg cttgttgatc aagagaaagt acagttggcg gcagaagccc ttctaagccg 3184441 agttcttgtc tttcttctag tgaaaaagca acgcctttat ttaaagtagg aatagataaa 3184501 acttcttttc ctctaagagt tgtttctaag tggccttctt tcgttttttt tatgttattc 3184561 aagcaaatct ccttctttct tgaaatagtt aaccaagtta agtaataacc catctaaaat 3184621 atgaccgatc atgatcttta tgcgactttg tgacaattat tcgaacaatg tctcaaaact 3184681 atttacatta cgtaagctat tgtatgcctg tcaaaatcaa aattcaagag aagaaaatta 3184741 cttaattttt taatatactt atttaaattt tttaattgaa tattatcaga atataaaaaa 3184801 aacaccggtg tttttagccg gtgcattcta tctttatacc catgttttgg actatttttt 3184861 agatttacct gggacttcgt gatgatgtct gcatcttgct tcatatgatt cagctgcacc 3184921 aaccaaaatg accggatcat cgtaagaagc aggtttgccg tcaatgaggc gctgtgttct 3184981 gctcgccggt gatccgcaaa cagaacagac ggcttgcagc tttgtcacac tttccgcaat 3185041 cgccatgata ttcgggacga caccgaacgg ctctccccta aaatccatat caaggcctgc 3185101 tgctatcaca cggtagcctt tatcggcaag agatgataaa acctcaacaa tttcctgatc 3185161 aaaaaactgc acttcatcaa ccgcaaccac atctgtactt tcactgatgt gatcccaaat 3185221 gtccgcagca gacgaaatgg catagctcgt catcgatgtt ccattatggg agacaacagc 3185281 agcttcgctg tatcggttat caattacagg cttaaatacc ctgacttcct gcttggcata 3185341 agttgctctc ttcactcttc tgatcagctc ttcagatttc cccgagaaca tgctgccgca 3185401 aatcagctca agccacccgc tttgtttcat tatgtacata ggcttcgctc ccctctctct 3185461 gccagctgtg ttttagacaa tataaaaaac aggcaagact gctgcttgcc tgttgagaaa 3185521 tctattatta cttaagaccg tattttttgt taaagcgatc aacacgacca tcagcagaag 3185581 cgaatttttg acggccagtg tagaatgggt ggcattcaga gcaaatctca acgcgtacct 3185641 cttcttttac tgagcctgtt tcaaattcat ttccgcaagc gcatttaact gttgcttttt 3185701 tgaaattagg atgaattcct gctttcattg tatccatctc cttccgccct gaatcccgtg 3185761 tggaaacaga gttattattt cggagcattg tccgaaacgc atatgagaaa attatatcag 3185821 tgatttactt cttttgcaaa tacaatttac cttcttgcag atgatagatt tgcctgtttc 3185881 cattcttgat tgagaatatc gaaaaattcc tggtttgttt tggttttttt catttttctc 3185941 atgaactttt ctgcgaaatc aggtgaatca gacatcgttt tgcggataga ccataaacga 3186001 tcaagatgct ctttaggcac aagcagctct tctttgcgcg ttcctgaacg gcggatatcg 3186061 atggcaggga agatgcggcg ctcggcaaga gagcggtcaa gatggagctc catgttgcct 3186121 gttcccttga attcttcata aatgacatca tccatacgtg aacctgtatc gaccagagcc 3186181 gtagcaagga tggttaagct gccgccctct tcgatatttc tcgcagcccc aaagaagcgt 3186241 ttcggacggt ggaacgccgc tgggtcaatc cccccggaaa gcgttcttcc acttggcgga 3186301 atcactaagt tgtaggcgcg ggcaagacgt gtgatgctgt ccatcaggat aatgacgtct 3186361 tttttgtgtt ccacgagacg catcgcacgt tcaagcacaa gctcggccac tttgatatgg 3186421 ttttccggca cttcatcaaa cgttgagctg acgacatccc cagctacaga gcgctcgata 3186481 tcggttactt cctcaggtct ttcgtcaatt aaaagcacga tcagctctgc ttcaggctgg 3186541 ttcgctgtaa tgctgttggc aatttccttc agcaacatcg tttttccggc tttcggcggc 3186601 gcaacaatca atccgcgctg cccaaatcca accggcgcca tcatgtccat aattcttgta 3186661 gacaagaagt tcggctttgt ttcaagcacc atttgacgat ccggataaag tggcgtaaga 3186721 gccgggaaat gcacacgctc ttttgcagat tcgggatcat ccccatttac tgcttcaacg 3186781 tgcaaaagtc catagtaacg ctcattttct tttggcgggc gaaccttgcc agatactttg 3186841 tctccgttcc gcaaatcgaa acggcggatt tgtgaagctg agatgtaaat gtcttctgag 3186901 cttggagagt agttgatcgg tctcaggaat ccgaaacctt cagactggat gatctcgaga 3186961 acgccttcca taaacagcag atcttcctgt tctgcattcg ctttcagaat ggcgaaaatg 3187021 agttcttttt ttgtcagttt gctgtaatag gagattttat aatgtcttgc aagttcataa 3187081 agctctttca atttcatatt ttccaaagag gaaatagata cgtctttcat aaaaacacca 3187141 cgcttttcat agtcaatatc ttactctgaa catgtcatct gctgcttttg cacaacatcc 3187201 gccaaagcac attctttttt taacataaag gaacttctat cggtaacact tccacccatg 3187261 atcggcgctt ttgttaaaag gattgtctta atgagttttg aaggaagcga ggacaaaaac 3187321 atgagaagat caatacttat atcgtctgta tgcggtagaa attgaaactt tcctagtgct 3187381 taaaagaagg tattacgcag taaaattcgc agcactcttt atttttacct tatttcaaaa 3187441 aattattcaa ctgaaataag gttttgacac ggaattgata gagttgacgc ttttctgcaa 3187501 aagttaaagc gggctcacac ccgctttttc tgtttgttat ggacggatta caagatttgg 3187561 tttctttttc aagctgtgtc tgccgtcaac gaaacgaaca gtgcccgatt ttgcacggat 3187621 aactaagctt tcagttgtac cgacagagcc tttgaattga actcctttta acagctcgcc 3187681 gtcagtaacc cctgtagctg caaaaatcgc gtcatcaccc ttcacaaggt cttccatgcg 3187741 aagcactttg cttaaatcaa ggcccatttt gtgacagcga gtgatttctt cttcgctttg 3187801 cggaagaagt ttaccaatga tttctccgcc gagtgctttt agcgcaacag cggaaagcac 3187861 accctcagga gcgccgcctg atccgaacag gatatcaacg cccgtgtggt cgaaagccgt 3187921 gttgatggcg cctgcgacat cgccgtcatt gatcaatttg attctggcgc cggcctcacg 3187981 aagctcggaa atgatttttg cgtgtctttc acggtttaaa attgtggcaa cgacgtcctc 3188041 aacgtccttg tttttcgctt ttgccaccgc tttaaggttg tcaatgacag gtgcttcgat 3188101 gtcaatgcag cccaccgctt ccggaccgac tgcgattttt tgcatataca tgtcaggagc 3188161 attcagaagc gtgccatggt ctgcgaccgc gataaccgtc agcgcgttcc agccgccgct 3188221 tgctaagatg tttgtgcctt caagagggtc aactgcgaca tcaacgcgag ggccgtaccc 3188281 gtttccgagt ttttccccga tatacagcat tggcgcttcg tccatttccc cttcaccgat 3188341 tacaacggtc cctttcatcg gcactgtatc aaaaacgtct ctcattgcac ttgttgccgc 3188401 ttcatcagcc tcatcttttt ttccccggcc catccatctt gctgatgcca atgccgcagc 3188461 ttctgtcaca cgtaccaatt ccattgataa acttctttcc atttcaacac gatctcctct 3188521 cacaagaaac cattatgaat tttgaagctg ttctatttct tcgtcagtca ttctttcacg 3188581 ccaaattgtc gctccaagcc cctcaagctt cttctcaagg ctgctgtatc ctcggtcaat 3188641 atgctccagt cccgtaattt ccgtgacgcc atcagccatc agtccggcta ccaccaagca 3188701 ggctccggca cgcagatcac tcgccttcac ttttgcgcct tgaagctcga caggacctgt 3188761 gatgatggca gatctgcctt ctactttcat attggcaccc attcgtctca gctcatcaat 3188821 gtgcttgaat cttgccgagt agatggtgtc tgtgacgaca ctcgtccctt tcgcccttgt 3188881 caggagcgcc gtcatcggct gctgtaaatc agtcggaaac cccgggtata cgagggtttt 3188941 gacgtcaacc ggctttaagt tcttctgccc gccgacaatg aggagctggt cgtcgcttgt 3189001 ttcgatatga tagcccattt ctctcagctt tgccgttaac gactcaagat gagtagggat 3189061 gacgttatcg ataatgactt ccttgcccat tgcagcccct gcaatcataa atgtcccggc 3189121 ttcaattctg tccggaatga tcgtatgctt gcagccgtgc agttccttca cgccgtcgat 3189181 tcgaatcaca ttggtgcccg cacctttgat tttggcgccc atgctggtaa gcaatgtcgc 3189241 gacgtcaatg atctcaggct ccttggcagc gttttcgatg atcgttttcc cttctgccaa 3189301 aacagcggcg agcataatgt taatcgttgc cccaacgctt acgacatcta aataaatccg 3189361 tgcgcctctc agcctttcag ctcgcaaata aatggcgcct tgttcattgg ttacttcagc 3189421 tccgagtgct tcaaagcctt tgatatgctg atcaatcgga cggggcccta agtgacagcc 3189481 gccaggcaat ccaatgaccg cctgcttgaa gcggccgagc atcgccccca ttaaataata 3189541 tgacgcgcga agctttttta ctttcccgtt aggaagcggc atgctgatca tcgacgtagg 3189601 gtcaacaacc atttccccat tctcaaaatg cacgttgccg ccgatttcct ttaacaggtc 3189661 acgcagcgtt tcaatatctg aaatctctgg aagcccttca attgtcacct cggaatttgc 3189721 caaaatggtt gcaggtatta acgcaacagc gctgttttta gcgccgctga tatgtactgt 3189781 accgtttaac gagtcaccgc cggcaatatt caacttttcc atgatagtct ccttccataa 3189841 gaagatagct gcggagctaa ataaaatgtc attttattct gtctctgcaa ataaagctca 3189901 tgtccaaaat ctagccaatt cgaagagaaa gaatacaaca cattgtaaaa tatcaggaag 3189961 aaaatagcga agctttgggg ggtacaggtt tcaaaagatg cacagagacc cgccggctcg 3190021 agagacatcg tcgtcatccg gcaaaagcag tacgcatacc cttcattccg atatcagctt 3190081 ctgcagccca atgattcctt ctctgtaaag cggcgtcagc atctgaagat ccgctgtatc 3190141 aggtcggtga aatacaaagg ccgcggcaaa caggcataaa gctgtttgcc gcccctttca 3190201 ttatttgttc cagtctgcca ggaattgttc gattcctttg tctgttaacg ggtgtttagt 3190261 gagcgcatga atgactttca gcggcattgt gccgatatga gcccctctaa gagcagcttc 3190321 tgtcacgtgc tgcggatggc ggattgacgc tgcaatgatt tgcgtgtcaa ggccgtgaat 3190381 gtcaaaaatc tgtttaactt ctgaaatcag gtcaagcccg ttgtggccga tgtcatctaa 3190441 acgtcccagg aatggagata catatgttgc ccccgctctg gcagcaagaa gcgcctggtt 3190501 ggcattgaag atcaatgtaa cgtttgtttt gatgcctaag tcagtaagtg ctcttaccgc 3190561 ttttaaaccg tcagacgtca ttgggatttt caccgtaatg ttcggagcga tcttcgccag 3190621 ttcttttcct tcctcgatca tttcctcagc tttcaaagaa ataacctctg cgcttacaga 3190681 ccctttcacg acgtctgtga tctcgcgaag acggtcgtgg aatgatacgt tagcttcctt 3190741 tgctactaaa ctaggattcg tcgttacacc ggcgagaatt cctaattcat tcgcttctct 3190801 aatttcatcg atattggctg tatcaacaaa gaataacatt ttcaaaaagc ctccctgatt 3190861 aagaaatttt ctgaactgcg aatatgattg cgctttctaa agatagacgg aaaaccgcct 3190921 gtcaagctgt caggcggcta taaaaagttc caattgaatt aagcttggtt tgaagaacca 3190981 aattcacgca ttttaccgat aactgtttct ttgatcgctt cacgagctgg tccaaggtat 3191041 ttacgtggat cgtactcgtc aggcttagct gccaatgttt cgcgaacagc ttttgcagaa 3191101 gaaatttggt tttcagtatt cacgttgatt ttagctgtac caagtgaaat tgattttttg 3191161 atgtcagcag tcggaattcc agtaccgccg tgaagaacta gcggaaggcc agttgatttt 3191221 ccgatctctt ccatttcttt gaagccaagg tttggctcac ctttgtaagg gccgtgaaca 3191281 gaacctaatg caggtgcaag gcagtcgatg ccagtgcgct caacaagctc ttggcactct 3191341 ttaggatcag cgtagattac gccttcagcg ataacgtcat cttcttgtcc gcctactgtt 3191401 ccaagctcag cttctacaga tactccgtgg aaatgagcaa gctcaacaac tttagcagtt 3191461 gttgctacgt tttcttcaaa tggatggtga gaagcgtcga tcattacaga tgtgaaacct 3191521 gcatgaatcg ctttcgcaca agattcaaag cttgaaccgt ggtctaagtg aatcgcaaca 3191581 ggaactgtca ctttgtactc ttccataagt gcttttacca tagcaacgac tgttttgaag 3191641 ccgcccatgt agcgtcccgc accttcggaa acaccaagga tcactggaga tttttcttct 3191701 tcagctgctt gtaaaatcgc ttgagtaaac tcaaggttgt ttaagttaaa ttgtcctaca 3191761 gcgtaccctt tttctttagc tgtattcaac atttccgtca tagaaactaa aggcatgtcg 3191821 aatgtcctcc ttatgtagcc tgattgtctt ctagcgaaaa aagctttcca ccctagcatg 3191881 acccatatat tgctgtcata tgtaaatact cagatcgctt tttctccata actaggatac 3191941 caacttttcg acaaatcggc aacataatga catgattcat ttgtttcttc tttttgtcag 3192001 ttagacttca ggggcagata ttttttgacg gcgtctctga tttcgtcgat gtcaaacggc 3192061 ttggcaaagt gcgtcagagc gcccaattcc ttcgattcct ggatcatgtc gagctctccg 3192121 tatgccgtca tgataatgac ccggatgttt tcgtcaatga ccttcatccg ttttaagatt 3192181 tcgattccgt ccatgccggg aattttcatg tccaacagca caaggtcggg ccgttctttt 3192241 gtcacaatgt caagcgcctg caggccgttc gcagcctgaa acgtctggta gccttcttta 3192301 ttgaacactt catttagcaa aatacgaatg ccgtattgat catcaacgat taaaattttt 3192361 tcattcatca ttttacaccc caatattatg attttcgtca aaagtaagca gtattgtatg 3192421 tattctgttt gattttccta tttcctttaa ttataatagt ctactttacg acattttctg 3192481 agcattttct cttttgttgt atactgatat tgtacgttat aaaggaggat tcacttatgt 3192541 tgaaaatatt cacgacgcag ttaacaggta ttttttcccg cattcaggat aaggaatctg 3192601 acgcgattga agatggggcg cggctgcttg ctcaagcggt gatcagcggg cattccattt 3192661 atttatacgg agcgaatgag cttcagggcg tcttttatga ggccaccgaa agcaaagaac 3192721 ccttcccatc tgtcaaagcc tttccagaaa acgctgagga agtgacagaa agcgacaggg 3192781 tgctgatgtt ttgctcaggg acgggcacag ccgaagaaca ggagctcgca aaagagcttt 3192841 atgaaaaagg tgcgggagtc gtatgcgtat cgcccgcagc caaagacagt gcgggaatag 3192901 aacagtattg tgatgtgcat attgattcta aattaaaaat gccgcttgtt cccgatgaag 3192961 acggcacccg ttacgggttt ccctctttaa tgacagcact gtatgtctat cacgctttat 3193021 cgtttacact aaaagaaatt ctgcaagagt atgcataata tcttattgta catgctggaa 3193081 cttgccggaa acaaataaaa aagacttgcc cgcttttgac aaacggcaag tcttttttat 3193141 tacttctgat ttgcagcttc gacagacgct ccgataaagc ctttgaatag aggctgaggt 3193201 cttgtcggtc ttgacttgaa ctctgggtgg aactgagaag ccacgaacca agggtggtct 3193261 ttcagctcga tgatttcaac aaggcgtcca tcagggcttg tgcctgagaa tacgaagcct 3193321 tgctcttcca tttgctgtct gaattcattg ttaaactcat agcggtggcg gtggcgctcg 3193381 tacaccactt catcctgata cacttcaaag gctttcgtgc cttcttcaag cttacaaggg 3193441 taaaggccga gacgaagcgt tcccccaaga tcctcaacat ccttttgttc aggaagaaga 3193501 tcaatgatcg ggtattgagt tgacggatca atttccgctg agtgagcgcc ttttaagccc 3193561 aatacgtttc gtgcgtattc aatagacgcc acctgcatgc ccaagcaaat gcccaagaac 3193621 ggaatgttgt tttcgcgcgc gtattttgtc gcgacgattt tcccttcaac accgcggtct 3193681 ccgaatccgc ccggcacaat gatgccgtct gttccgcttg tgagttctgc gatattgttt 3193741 tctgtcactt cttccgcgtt gatccacttc acttttacat ctgtgtcaaa cgcatagccc 3193801 gcatggcgga gagactcgac aacagaaatg tatgcgtcag gaagctcaac gtatttgccg 3193861 acaaggccga ttgtaatcgt ttgagacagg ttgctgactt tgttaacaag ctctttccac 3193921 tcggacattt ccgcttcttt gcatgccaat ttcatgtgct cgcaaacaag cttatcaagc 3193981 ccttgttttt gaagctccag cggaatggag taaaggttgt ccgcatcttc acattcaata 3194041 accgcttttg tatcgatgtc gcagaaaagc gcgattttat ctttcatatc ttgagaaatc 3194101 ggcatttctg tacgaacgac gatgatgttt ggctgaatgc ccaagctgcg caattctttt 3194161 acgctgtgct gtgtcggttt tgtttttaat tcgccagcag ctttaatgta aggcacgagc 3194221 gtacagtgga tgtacattac gttttcacgg ccgatgtcgc tcttcatttg gcggatcgct 3194281 tcaaggaatg gcagtgattc gatgtctccg acagtaccgc cgatttctgt aatgacaaca 3194341 tctgcgtttg tctctttccc tgcgcggtaa acacggtctt tcaattcgtt tgtgatgtgc 3194401 ggaatgacct gtacggttcc tccaaggtaa tctccgcggc gttctttttt aagaactgtt 3194461 gaatagattt tacctgttgt cacgttgctg aatttattca ggttaatgtc gataaaacgc 3194521 tcatagtgac caaggtccaa gtctgtttca gcgccgtcat ccgttacgaa tacttcaccg 3194581 tgctggtacg ggctcattgt tcccgggtca acgttgatgt atggatcgaa tttttgaatc 3194641 gtcacgttca gtccgcggtt tttcagcaaa cgccctaatg aagctgctac aatacccttt 3194701 ccaagtgagg atacaactcc cccggttaca aaaatatatt tcgtcatttc gtttgctcct 3194761 ctcttcgctc ttagctacat ttttaaaatg tactatttta taaaaaatca tttagccttt 3194821 taaatgattt ataagaaaaa tgaggggtga aaataagaaa gctccctttc aatttcttga 3194881 aagggagcat aacgtactat gttctctctt cgtttttgaa gagcccaaaa tacatactac 3194941 atagttcgac tatgaaagtc aagatcgttt tgaagatgaa atctgatact atttaatttc 3195001 ctcttcttca tcatcatagt cttcatcatc ttcatcaata atatcttctt cgatctcaag 3195061 atcatcgtcg tcttcatcaa gatcttcttc gtcaaaatcg tcggcttcaa gatcgagttc 3195121 ttcctcaact tcatccaaat caaggtcgtc ttcgtcgatc tcttcaaact cgtcaagatc 3195181 aagatcttct tcgactgctt tcttcgcttt tttctttttc gccttgactg tcggctgagt 3195241 ttcttcatca agctgatcat aaggatacca gctgcgaagc ccccacgtct ggtcagaaag 3195301 cgccaggaag cggccgtcaa tgtttaaatc tgtataaaat tgagcaatgc ggtctccaag 3195361 ctcttctttt ttcacgccga gcaaagatgc gatttcattt aaaagctcct gaaaaggaac 3195421 tggtttttta tgttcttcaa ataattcgtg agcgatttca actaaagcca tttcctttag 3195481 ctcttcctgt gaatattgtt tgatacccaa ggtcggacac tccctttcta ttacttatat 3195541 gtatctgttt tatcaataat gaaagcgatt ttgtatcgtt cttatacaaa ccatacctct 3195601 cattataaac aaaataaaac agaatatgct acccttaaca gcgttaattt aaataatttt 3195661 acaagagtga tccgactgag agatgttttc cgttaatccg cgagcattct ggagatgacc 3195721 agtctttgaa tttcttgagt gccttcatag atttgcgtga tttttgcatc acgcatatag 3195781 cgttctaccg gataatcttt tgtatagccg tagccgccga aaatctgcac ggcttcggtc 3195841 gttaccttca tcgccgtatc cccagccatc agtttggaca tggcggaagc ttttccatat 3195901 ggaaggcccg atgattctaa ccatgcagcc tgataggtca gtagccttga agcttctatc 3195961 attgtcgcca tatccgcgag tttaaaagcg atgccctgct gctcggcgat cgattttccg 3196021 aattgctttc gctcttttgc atattgaagc gccgcatcaa gcgctccttg ggcgatgcct 3196081 acagcttgtg cagctatgcc gtttctgcct ccgtcaagcg tcttcatcgc gattttgaag 3196141 ccttctcctt cttctccgag acgctttgat gcgggcacta cacaatcttc gaacatgatt 3196201 tccgttgtcg gtgaagaacg gatgcccagc ttcttttctt tcttgcctgt aaaaaatcct 3196261 tcaaaatcct tttctactat aaaagcggta acgccttttt tctttttctc gggatcggtg 3196321 acggcaaaaa caatgtaaat atcagcaacg ccgccgtttg tgataaacac tttggaacca 3196381 tttaacacat agtcatcgcc gattcgttca gcagttgttt tcatgctgcc ggcgtcagag 3196441 ccagaccctg cttcggtcaa agcgaatgcg ccgattttct ctccgagagc cagctgtgtt 3196501 aagtactctg tcttctgttc ctctgtccca aaggcaaaca gcggccagct gcaaagagag 3196561 atatgggcgg aaagcgtcac accggtggag gcgcacactt ttgacagctc ttccaccgcg 3196621 atgacgtagg ctaaatagtc acttccaatt ccgccgtaat cttcaggcca tggaattccc 3196681 gtcaggccca gatttgccat ttcccgaaac agctcgcgat cgaagcgttc ttgttcgtcc 3196741 cgttcagccg ctgtcggggc cacctcatgc ttcgcaaaat cgcgcaccaa ttttcgtatc 3196801 atctcatgtt cttctgataa tgaaaaattc attgcttctc ccccattttc agatcagcgc 3196861 ctaaaacgga ttgagccaga agctcgacga cgtcgtacgt tttgacttgg tcttcggctt 3196921 ccttcgcctt tgtgccgtcc ccaagcatcg tgagacaata cggacagcca gaactgatca 3196981 ccgatgggtt gactgcgagc gcttgctctg tcctggcgac gttaatcctg ttgcctgttt 3197041 cttcctccat ccacattaat cccccgccgg ctccgcagca catgccggtt tcccggcttc 3197101 tctccatttc aacaagctgc acgcccggaa tggctttcaa aatctctctc ggcggatcat 3197161 agacttcatt gtaccggccc aaatagcacg aatcatggaa ggtaatcgtc tcatgaagcg 3197221 ggtgctgcgg tcttaatttt ccgtttttca caagctcggc cagcacttct gtatgatgat 3197281 aaacctcgcc ttcaaatccg aaatccggat attcgttttt aaataaattg tatgcatggg 3197341 gatcgatcgt aacgattttt ttgacatcat ttttttcaaa ttcagaaata ttcttctcag 3197401 ccagctcttg gaacaaaaat tcatttccga ggcggcgcgg cgtgtctcct gaattttttt 3197461 ctttattgcc gagaatcgcg aaggacacgc ccgcgtgatt gagcagcttg gcaaaggaaa 3197521 ttgcgatttt ctggcttctg ttgtcgtaag accccatgga gcctacccag aaaaggtact 3197581 caaattcttt tccttctttt ttcatttctt ttacagtcgg aatctcagca tccggcgcct 3197641 cgtcacgcca attttcacgt tccttgcggt tgagtcccca cggattccct tgccgctcaa 3197701 tacttgtcat tgcgcgctgg gcgtcactgt ccatttttcc ttctgtcagt acgaggtagc 3197761 ggcggaggtc gatgatttta tccacgtgct cattcatgac cgggcattga tcctcacagt 3197821 tccggcaagt ggtgcatgcc caaatttctt cctctgtgat gacgtcgccg atcaagcttg 3197881 gattgtaatc aagcgccgct gcggcttcct gcgatccgct gcccgctgac gccgcagcca 3197941 gctgattgcc tctcgtatgc cgaaacgctg ctgcgggcac ccatggggag cgcgaggtga 3198001 cggcagcgcc tttttccgtg agatggtctc tgagacgcaa aatcaagtcc atcggagaaa 3198061 gcatttttcc ggtgcctgtt gcaggacaca tattggtaca gcggccgcac tcgacacacg 3198121 cgtatagatc aagcagctga gactgtctga aatcctcaat ttttcccgct ccgtagcttt 3198181 ctttcgtttc gtcggtaaaa tcaatttttt caagttttcc ggcagattcc attcgattga 3198241 aaaagacgtt tgccgggccg gcgattaaat gggcatgctt tgactgaggc acgtacacta 3198301 aaaagctaag caagaatagg agatggatcc accatgcgat atagaaaatc accgccgcgc 3198361 ctgttttccc gacaccgcta agcataaacg caatacctga ggcaattggc tcgctccaag 3198421 aaagcccatg ctcatgccaa atcagattca tcccgttccc aagcagaacg gtcagcatta 3198481 atcctccgat aaaaatgaga acgagtccgg ctttgaaacc gcgtttcagc ctcacgagct 3198541 tttcgatata acgtctgtag aatgcccacc caacagcaat taaaatgaga aacgtaacaa 3198601 tttcctgaaa aaaggtgaag gcgggataga ccgggccaag cgacagattc cggccgggag 3198661 ccagtccttt gatgataaag tcaattgctc cgaactgaac caatataaat ccgtagaaaa 3198721 acatgacgtg aatgattccg cttttcttgt ccttgagcag ttttttctgt ccgaatacat 3198781 tcacccatat ggcgtgaagc cgttccttga accgttgatc aaattgttct ttctggccga 3198841 gcttgatgta ggccagtctc gttttgacca agtaaacaaa caaatagaca gcgtaagcgg 3198901 ttacaatcag aaataataat gcatttgcga tgagaaagcc gctcattcca attccccctt 3198961 tttactgata aagaccgcga tcccctaccc ccgaatctgt ataagattat ctttatgata 3199021 aataatgaat gagtgttcag tcaataatta aattcctgct gttcgggcac actaccttta 3199081 ctacggaaag gagtgccggt atgaaggtat ttatcgtgat tatgatcatt gtcgttattt 3199141 tctttgcctt gattctgctt gatatcttca tgggccgtgc cggatacaga aaaaaggcgt 3199201 acgagcctgt tttttcaaaa aagaagagtg acatcgaatt gatccactgc ggcgctgatc 3199261 tcgttgagcg gatgatgaat gatattcgcc aggccgcctc ttctgttcac atgatgtttt 3199321 ttattatgaa aaatgatgag gtcagccaca atatgtatac cttgctgaaa acaaaagccc 3199381 aagctggcgt atccgtttat ttgcttctgg attgggcggg ctgccgggca attaaaaaaa 3199441 cggcgcttca gacgatgaaa aatgccggcg tccatgtcca tgtgatgaat cgtccccgtt 3199501 ttcctttttt cttttttcac atgcaaaaac ggaatcaccg gaagattacg gtgatagacg 3199561 gaaaaatcgg ttatatcggc gggtttaata tcgccgaaga atatcttgga aagaaggcga 3199621 agttcggcaa ttgggaggat tatcatctgc gcatgatcgg agaaggcgta catgatcttc 3199681 aaacgctttt tgcttctgat ctaaaacgaa ataccggaat cgaactgggt tcggatgttt 3199741 ggccaaagct tcagcaaggg actatttctc acaagatcta tgcgaccgac ggttattccc 3199801 ttgaaaacat atacttggcc aacattgccc aagcgaagaa tcgccttacg gtttgcacgc 3199861 cttattacat tccatcaaaa ccgcttcaag aggcccttat taacgcaaga aaaaacggcg 3199921 tatccgtgag aatcattgta ccgatgaaat cagaccatcc gctggtacga gaagcggctt 3199981 ttacgtatta ttcggagctc ttggatgccg gctgtcttat ttatcgttat tatcaagggt 3200041 tttatcatgt aaaagccctc atcatagacg accatctcag cattatcgga acagccaact 3200101 tcgataaacg gagcctgttc ttaaatgaag aggtgaatgt tgaaattgat gacgaagcgt 3200161 ttacaagtga agtctatgcc acaattgagg aggatatgaa aaagtcggag ctgctgacga 3200221 tggaggattt cagcaagcgc acattcaggc agcgcccggc ggaatggctc ggcagggcat 3200281 tatcttattt cttataaagg agagttccta tgattttcag attcgggttc gtttcaaatg 3200341 cgatgagcct ttgggatgcg tctcccgcta aaacattgac attcgcgcgt tattcaaagc 3200401 tttcaaagac tgaaagaaaa gaagcgcttc tgactgtgac aaaagccaat ttgcgcaata 3200461 cgatgagaac ccttcactat atcatcggcc acggcattcc tttgtaccgt ttttccagtt 3200521 cgattgtgcc gctggctacg catcccgacg tgatgtggga ttttgtaaca ccgtttcaaa 3200581 aagagtttcg ggagattgga gagcttgtta aaacccatca actgcgaaca agctttcatc 3200641 caaatcaatt cactctgttt acgagcccga aggaatccgt cacaaaaaat gcggtaacag 3200701 atatggcgta tcactaccgc atgcttgagg ccatgggcat tgctgatcgc tccgttatca 3200761 acattcatat tggcggcgct tacggaaata aagacaccgc cactgcacaa tttcatcaaa 3200821 atataaaaca gctgccgcag gagatcaaag agcggatgac acttgaaaat gatgataaaa 3200881 catatacaac ggaagaaacg cttcaggtct gtgagcagga ggatgttccg tttgtctttg 3200941 actttcatca tttttacgcc aatccagacg atcacgccga cctgaatgta gcactgcccc 3201001 gcatgatcaa aacgtgggag cggatcggcc ttcagccaaa ggttcacttg tcttccccaa 3201061 aatcggagca agcgatacgc agccacgccg attatgttga cgccaacttt ttgctgccac 3201121 tgttggaacg ctttaggcaa tggggaacta atattgattt catgattgaa gcaaagcaga 3201181 aagacaaggc gcttctccgc ttgatggatg aattaagctc catccgcggt gtcaaacgca 3201241 tcgggggcgg tgcgctgcaa tggaagtcat aaatgtgcaa aaataggttt acgacttgtc 3201301 agctttggga acttaggcta tataagacaa caatcgatgg aggagaaaga tcatgaaaaa 3201361 tatcaagtct ctgaaagtag ccgcacaggc ctttacttta agaaatttga ttcatcttta 3201421 taaaatgtgc cattccggaa gccacgaggt ttatatttat tcaaagaaaa cgatgtgcaa 3201481 aatcaaaagc ttaattgagc ttgaaacgtt ccgcatggct cataatgaaa aggaatatct 3201541 gatcgtagtt gaaggaacaa aagcatcaca gctcattgaa aaattccaaa atctcatcga 3201601 gcctgctgag agagaagcgc tctaacttac atacaaaaaa ggatagacat ctgtctatcc 3201661 tttttcttat gctcttacat aatggagctg aaccgcttgt ccaaattgtt ttgtcccttt 3201721 taaccgcagt tttgtttcat ttgttagttc gtgaaacagc gggatgccgc ttcctaaaac 3201781 gacgggaata acagtgatga tgaattcgtc gatggcatct tctttcataa agtcattcac 3201841 aagctctgcc ccgccagcta tccagatgtt tgagcctttt tcctgtttca aacgggcagt 3201901 gaaggctctg gctccctcat tgataaacgt cacatgttca tcttgataac tgtcgggcga 3201961 tcctgtaaaa acatagcagg ttttatcctg atacgggaaa accggtgtta gcactttaac 3202021 gtgctcatat gtgctccgcc ctaaaatgac tgtatcaaca gtctgataaa aatcactgta 3202081 gccgttgtca ccttcacctt caaattcatc cagccaatcg atgcttccat cttcttttgc 3202141 gatcatcccg tccaatgaaa cagcaatgta cagcacagtt tttctttcca tgttctcctc 3202201 ctatcgatgc accatttgcc cgaattgcgc ttgatgcagc ctgctgtata ggcctccggc 3202261 ttcgatcagg tcttgatgac ggccttgttc ttcaataccg ttgtttgtga cgactacaat 3202321 tctgtccgcg tctttgattg ttgccagcct gtgggcgatg acaagcgtcg tgcgcccctc 3202381 agacaactct tgaagcgcct tttggatcgc cgcttccgtc tctgtatcaa gggctgaggt 3202441 ggcttcgtcg agaatcaaga tcgacggatt tttcaagaac atccttgcaa ttgacagacg 3202501 ctgtttttgc ccgccggaaa gcttcacgcc gcgttcgcca atcatagtat ccaacccatc 3202561 gggcatgtta tggacgagct cttccagatg cgcctgcttc acagcttgcc aaatgtcttc 3202621 ttctgatgcg cctagtcggc cgtaggcgat attttctcta agcgtgcccg agaataagaa 3202681 aacgtcctgc tgcacgacgc caatctgccc gcgcaacgaa gaaagcgtca tgtcttttat 3202741 actgatgccg tcaatcgtaa tgtcgccctc cgatgcttca taaaaacgcg gaagcagact 3202801 gcaaagcgtt gatttcccag cacctgacgg accgacgaac gccaccgttt cccccgcttg 3202861 aatggatagg ttgatgtcat tgaggacatt gtgatggtca tcatagccaa acgaaacatg 3202921 tttatagcgg atattgccct tcaggccgga aacatctttc gaatcaggtg agtcctgaat 3202981 atccggctct gtctccatga gctccatata gcttttgaaa cccgcgatcc ccctcggata 3203041 catttcgata atggcattaa ttttgtcaat aggcctgaac agcacattcg tcaagagtac 3203101 aaacgccaca aattccccgt acgataagga gccgcgaatg acaaaccacg tcccgcacaa 3203161 aaggacaaac agcgtgacaa accgggtcag catatagctg attgaaccgt ttttcgccat 3203221 gattttgtag gaagaaagct ttgtgacacg aaaacgctgg ttgttgacgg cgaagcgttc 3203281 tttttcaaat gcttcatttc cgaacgcctg cacaagccgg atgccgccga tgttattttc 3203341 tacacgcgcg ctgaagtctc cgatatcctt gttcagcgtg gtaaatgctt tggtcatttt 3203401 tttgttgaaa taaagcgcta gccaaatgac gatcggcata atgataaacg ttaataaagc 3203461 aagctgccag ttaataaaca gcatcactcc gaacgccccg agaatggtca tgaccgcaat 3203521 gaataagtct tccggtccgt gatgggcgac ttcaccgata tacattaaat cgttcgtgag 3203581 cttcgacatc agcgttcccg tcttgttgtt gtcgtaaaat ttgaacgaga gcttttgcaa 3203641 atggtcaaaa agcgactttc tcatatcagt ctcaatattg ataccaagca tgtgtcccca 3203701 gtaggtcacg atatactgaa gagccgagct gagcgcgtac accgcaaata acccgattga 3203761 ggtcgcgatg atcagtcccc agtccctgcc cggcagcaag gtatcaataa aataattgac 3203821 gatcaaagga aaactcagct ccattaaacc tcccgcgatc gctgagaaaa agtcgagaaa 3203881 gaacaacgtt ttatatggtt tataatatga aaaaaattgc cgcagcaccc tatcttcccc 3203941 caatgtataa ataactgata atatttctca attatactat acacgggctg ttttgtaaga 3204001 tcagatttct tttttcttac agaacacctg aaaacaggcg ggcaaacgac tcttttgtcc 3204061 ggtcagccac acctctttta taaaagccga cagggctgag cttttcactt tcctgcatat 3204121 cctcttcaaa atgggcctca agggttcgga tcgcttcggc atccgtgaag aacacattca 3204181 cttcaaagtt gagctgaaag ctgcgcatgt ccatattcgc ggtaccgacg gaggcgagat 3204241 cgccatcaat gatcatgact ttttgatgca tgaagccttt ttggtaggag tacacttcaa 3204301 tgccctcaag gagcagctcc gggaaatagg acctcgacgc gtattgggtc aaaaagctgt 3204361 cgttcttctc cggcaccata acccttacct ctaccccctt tgtcgccgct gcttttagcg 3204421 ccgtgcgaat ggattcattg gggacaaaat agggcgtggc gatccatatt gatttctgcg 3204481 ctgaagaaat catttcataa taaaggtcgc tcatgctttc cttcatgtca gggcctgtcg 3204541 cgacaatttg ataaatgcct cctccttcca cgggaaccgg ggtattgtac tcctcttgat 3204601 caattagcac ttcattggag acatattccc aatccagcat aaagatagcg tggagcgttt 3204661 gcacaatttc cccctcaagc cgcaggtgtg tatctctcca aaatccgatg tacggatctc 3204721 tgctgatata ttccttcccg acatttaatc cacccacaaa accggttttc ccatcgatga 3204781 tcacgatttt ccggtgattt ctgaaattca gcttctggtt gaaaaacccg tatttcagcg 3204841 gagaaaacgg gacgatgtcc acccccgctt gtttcattct cataatatct cttcttgcca 3204901 gcttcatgct tcctgccgca tcgtataaaa acctcacctc gacaccctgg cgcgctttct 3204961 ccatcataat atccatcatg ccgcgtccga gcatgtctga tttaaacatg tagtattcaa 3205021 tatgtatgta agattccgct tttctcattg ctttgaaaat gtccgggaag gtttcttcgc 3205081 cgtttttcag cactttgatg ttgcttttcg tattgatatt catatgggca gccctgatgg 3205141 aatatgtaaa gaacctctct tgattgtcct tcagccctgt cacttcgggc gtttcctcct 3205201 tgtcaaacag cttcctgagc ttttccctgt tgtacattcg ttttgtctta aacagctttc 3205261 cctttacata aagctgtccc gaaaacagat aaaacacgta gccgacgatt ggaaaaaaga 3205321 caagaatatg gatccatagc agcgtgtgct gcgaggtgcg gttttcaaga attaatgaat 3205381 agatgctgaa caaaataatg cttatatagc aaagcaatcc tccgtaaaac tcaagtctgg 3205441 aaaccggaaa aaaccaaatg acatatgccc cgatgagcat catatataaa aagaaaaatt 3205501 ccagtctcct tttcagcatc ctgattctct ccaatctgat tcaattacct ctgtattacc 3205561 tcttttttct aatcgataaa ccttgtaagt aaaaaacctc tccgccaaag gaggagaggt 3205621 ttagagaaaa ctaactgtca cggaattcat ccgcatcgtt tctgcagaaa taaagcaaga 3205681 ctattggcaa cgccgagtga caacatgagc ggcaagctga acccgctcag cactccggca 3205741 agcgccgaaa agaaggcggc gctgtgactg caaatacggt ggatagagta aatttgatac 3205801 ccattctgat gagagaaaat atataaaacg ggaaattgat cagaaagata taaggagtta 3205861 gtcaggctga atcataatct ggctgttccg ccggtttaaa atgagtaaaa tccttgatgt 3205921 tatttccata tacaaacata acaggattcc cggcagccca gccattacct tggcagaaaa 3205981 aaccccctct tgcaaggggg attttcacga gcgtttccga tatacaacgt agctgcgggt 3206041 cagatacttg agcggcagac tgaacacatg aaccaatctc gtaaacggcc acaggataaa 3206101 aacgacgtat cctatcacaa tatgaaactt aaaccatagc gggacactct ccatcaaaga 3206161 ggcgtcaggc ctgaacaaaa cgatttccct gaaccagggc ccgactgtgg tccggtaatc 3206221 aaatcctttc gaatcaatgt tgagaaacgt ggccgcaacg cctgacagca tcatgaacag 3206281 cagcaggagg agcgtaagga tatcggatgg cgagctcgtt ttgcggattc ttttgtcaaa 3206341 cagccttctg tacgtcagga tgacaagtcc ggtacatgcc gcaatgcccg ccggcaagcc 3206401 agcgccaatc gccattttgt gatacatatg ctctgaaatg ccaagggaag catacacgcc 3206461 ttctgggatc agaatcccca tgacatgccc gccgacaacg cacagcagtc cccagtgaaa 3206521 aagtgtgctg ccagccgcaa gttttttctt ttctaacagc tcgcttgatt tcgccgtcca 3206581 gccaaattgg tcatgctgat agcggtaaat atggccgccg ataaagattg tcaatacaat 3206641 gtatggcata ataccccaga ggatctgccc gctcatgcct gaacagcccc ttcaacgctt 3206701 tcacgtacgc caatgttttc aagcgcggcc agcagcacgt gcagcagttc agcgtatata 3206761 ctgtcatttt tttcgagacg ggatgccagc tccctcacat tggacagata tttctcaaac 3206821 acgcttctcg ctgcttcaat ttctgcagcc gcagcaaatt ccagcatcag cggcagataa 3206881 tcaggcagct ctttctctgt cggcaggaaa ccggattgct cgtatgtgtt ttttaaatgc 3206941 agcaattcaa tgccgcgttc cctttgctcg cctgagttaa agtaggtgac atacatattt 3207001 gtttttttcc cgaagtcgaa tgtatagaca tagtgttcaa tcagcgcttc cggagaatag 3207061 ctggctgacg tctcgaaaaa gtgcagcagc ttctcccgga tttgccggtt gccgatttct 3207121 tggataagag ccttccaatc gggaagctcg gctctccact cttcatccgg ataagagaga 3207181 agacaggaaa gagcagagaa cgtgatttgc cggtctgtgg tgttcatctt gttacacctc 3207241 atttatcaaa agttagaaac aggagccggg gccgcctgaa aatgataagc cgcagcttcc 3207301 ttgttcagcg tataaatctg atacttcttc tcgatggctg ctcggaatca caaagcggtc 3207361 atcatatttg gcaatcgcaa gcagccgata catatcttca atttgctgtt ctgttaagcc 3207421 gacactggag atcagttccg gatcgattga tttattcgtc tggaccgctc tcatatactg 3207481 gcgcatgaca gacattttct ttaatgttga ccgaatatga tccgtatcac cggctgttaa 3207541 cagctgcgcc aaataatcta tcgggattct catttggtcg atagccggaa aaatatcttc 3207601 cgccgtttgc cggctgcctt ttccttcaaa gagattcata atcgggctga gcggcggaat 3207661 gtaccacacc attggcagcg tgcggtactc aggatgaagc ggcagcgcga tcttccagtc 3207721 aatgatcatt ttatagatcg gtgattgctg cgcggcctct atccattcag ccggaatgcc 3207781 ttgttctttt gccagtttgg caacctcagg atcattcgga tcaagaaaaa cgtccaattg 3207841 ggaatggtag agatcctttt cattttcaac agatgccgct tcctccactt tgtccgcgtc 3207901 atatagcatg acgccgaggt agcggattct gccaacacac gtctcagagc agatggttgg 3207961 cagtcccgcc tccaaacgcg gaaagcagag tgtgcatttt tccgctttgt tcgtttgcca 3208021 gttaaaatag acttttttat aaggacagga tgagacgcaa tatctccatg aacggcatgc 3208081 gttttgatcc acaagcacaa tgccgtcctc ctcgcgtttg tacatggcgc cggatggaca 3208141 ggatgagacg catgccgggt tgatgcagtg ctcgcaaata cggggcaaat acatcataaa 3208201 gacgtcatcg aattctgttt tgatcgattc ctccatcttt tgtacgttgg gatcttcaag 3208261 tcccgtaatg tggccgcctg cgagatcgtc ctcccagttc ggtccccatt cgatattcat 3208321 gaaatccccc gtcaaggacg atttcgggcg tgctaccggc tggtgttttt tctgcgggct 3208381 gttcgttaat gtttcataat catagttcca aggttcatag taatcatcaa ttgacggctg 3208441 attcggatta tagaaaaggc ctgcaagccg attggttttc gagcccgatt tcagctcgag 3208501 ctttcctttt ttcaatgtcc agccgccttt atatttgtcc tggtcctccc attgcttcgg 3208561 gtagccgatg cccggctttg tttctacatt attgaagtac atatattccg caccggaacg 3208621 gtttgtccac gtgtttttgc aggtgacgct gcacgtgtgg cagccgatgc atttatccaa 3208681 gttcatgacc ataccgattt gcgctttaat cttcaagcca atcgacctcc ttcagcttgc 3208741 ggatgacgac gttcaggtcg cgctgattcc ccgttggacc gtaataatta aagccgtagc 3208801 tgagctgggc gtagccaccg atcatctgtg tcggcttgac gtgaatcctt gtcgggctgt 3208861 tatgggtgcc tccgcggtta ttcgtcagct ttgtgccggg cacgttgatg tggcggtcct 3208921 gggcatggtg cataaacgcc attcctttag gaatccgatg agacaaaacg gctctcgcga 3208981 cgacaacgcc gtttcggttg aagcattcaa tccaatcgtt gtctttgata tccgtgtcct 3209041 ctgcatcatc tttattcatc cacacggtcg gcccgccgcg gaacagcgtc agcatcggca 3209101 gagaatcaaa atacatgctg tggacagacc atttattatg cggcgtcaaa taattgagga 3209161 cgatttcttt tccctcttga tcaggccgtt tgctcagaaa cgggcgatgc tggaggatcg 3209221 gtttgaatgt cgccatcgtt tcaccgaatt ccatcatcag ttcatgatcg acataatagg 3209281 attgtctgcc tgtcagcgtc cgccacggaa ttaatttttc aacattcgtt gtaaacggcg 3209341 aatacctgcg ccctcctttt tcagagccgg taaacgctgg agacgtgatc accgttttcg 3209401 gctgggctgt aatttgttcg aacgtaaagc attcttcctc gcgttcttcc gccaggtctt 3209461 tcagcttcag gttcgtgatg ttttcaagtg attcccatgc ttttactgcg acctttccat 3209521 tcgaagtgga tgatagggtt aaaatcgctt ctgcagcctg ctttgcttca cttatatttg 3209581 gacatccctt tgccacgctg tccgaggtga tttctcccag tctctgtttg agtgattcat 3209641 attcatcggc tattgaccag ctcatccctt ttgttccgct cggctttaaa gcaacgttcg 3209701 gaccaagtgc agtcatttta tgaaaaatgt gtttgtaatc ccgttcaacg acttggatgt 3209761 tcggcatcgt ttttcccgga atggcttcac attcgccttt gctccagtca ttgattttgc 3209821 cgaatggctg ggccaattcc tgcatggtgt cgtggagcag cggtgtcgca accacttctt 3209881 tcaccggctc catatcgact tcttctgcca gatcggaaac ggcttttgac agcgccttga 3209941 aaatatccca gtctgacttc gattcccacg gagccgagat cgcaggagca aatggatgaa 3210001 tgaacggatg catatctgtg ctgctgagat cgtgtttttc ataccatgtc gccgccggca 3210061 gcacgatatc ggaatacagc gccgtacccg ccattcgaaa atcaagattg attaataagt 3210121 cgagctttcc ttccggcgcc tgctcccgcc atttgatttc ttctgggcgg atgctgtcgc 3210181 tgtcgtcatt cattaaaccg ttcgttgtcc ccagcaaatg cttgagaaaa tattcatgcc 3210241 cttttcctga gcttgagatc agatttgccc gccatacaaa gagattcctt gggaaattca 3210301 cttcattgtc aggatcttca atcgcgaatt tcagtttttt ctcttggagc tgtgaggcca 3210361 cgtacgcacc tacgtcttca ggtgttgctg cccctgcttt ttcagcttct ttatacagat 3210421 cgatgccatt ttgattgaaa gtcgggtaag acggaagcca ccctagccgc gccgccagca 3210481 cattgtaatc agcgtggtgc ttgtagcggg atgaagcagc aatcggtgat gccaaatcac 3210541 tgatcggctg gtcctcataa cgccactgat ctgtcgcaaa gtagaaaaat gaggtgccat 3210601 tttgcagctt gggcacgcct tcccagtcct ttgcagttgc aatcgtctgc cacccttcag 3210661 caggtcggag cttttcctgc cccacgtaat gggcccagcc tccgccgttt acgccttggg 3210721 cgcctacaag taaaacaaga tttaacactg ctcggtagat cgtgtcggag ttgaaccagt 3210781 ggttaatgcc ggcccctacg ataatcatgg accggccgtc tgtatcgatc gcattttggg 3210841 caaactctct ggcaatctta acgacagctt cttttttgat tcctgtcatt tgttcctgcc 3210901 aggcaggcgt aaacggctca gggtcatcat aggagacagc cgatcgttcg ccgatgcccc 3210961 ggttcacgcc gtagttagcc agtatcaagt caaacacggt cgtgatgtac gtttcttcac 3211021 cgttcaggtt cattttttta ataggaagat cccgctcgag cactttgttt ccgtcatttg 3211081 aaaaatacgg gatgcgcacc gtgccgattt cgtcctctat tcccagcaca gagagacggg 3211141 gttcaatcgg ttccccggtt tcttcatcaa tcatgtgcag gttccatttc tgctgcccgt 3211201 cccagcgcga gcccattgtc ccttggggta tggcaaatga acttgtctgt tcatcccaaa 3211261 ccgcaggctt ccactgatca tgctttgtct tccgcccgat gtccttcgca tgcagaaacc 3211321 gtcccgctgt gtatacgcca ttttcttttg acagagtgac gagaaatgga aaatcagtgt 3211381 attgcttcgc gtactcaata aaacgttcag tttcttggtt cacgtaaaat tcctgcagaa 3211441 taacgtgacc catcgccatc gcaagcgccc cgtcagtccc ttggcgaata ctcagccagt 3211501 catccgcgaa ctttgaggat tccgcaaaat ctggactgat cgaaatgacc ttagcgcctt 3211561 tatagcgggc ctccgccaaa aaatgcgcgt caggcgttct cgttaacgga acgttggagc 3211621 cccatgtgat aatatagccg gaattgtacc aatcactgct ttccggaacg tccgtctggt 3211681 caccccaaat ttgcggggat gctggaggaa gatccgcata ccagtcataa aaactgagca 3211741 tagggcctcc gattaacgac ataaaccggg agcctgatgc gtggctgatc atggacatgg 3211801 ccggaatcgg agaaaaaccg acgtttcggt caggcccgta tttcatcact gtatacagca 3211861 gagaggctga aatcagcttc agcacctccg gccattcagc gcgcacaaaa ccgcctttcc 3211921 ctctcgcctg tttataggac ttcgcttttt cagggttttc gacgatcgat ttccaggctt 3211981 ccaatggatt ttgatgcgtc tgcaatgcct cccgccacaa attgatcagc acaccgcgca 3212041 cgtatggata tttcacacgg agcgggctgt agatatacca tgaaaaactg gccccccgcg 3212101 ggcagcctct cggttcaaaa tcaggcatat ccgggcctgt tgatggataa ttcaaatttt 3212161 gcccttccca cgtgactatt ccgtttttca cataaatatt ccagctgcaa gaccctgtac 3212221 agttgacgcc gtgggtggag cgaacgactt tgtcgtactg ccatctgttt ctgtatacat 3212281 tctcccaatc gcgatcctcg cgggtagttt ggctatgttt atttgaatgg tgttcgatag 3212341 gagagaaata attcaatctc ctaaacaacg gactcctttt ctttttcttc atgagagttc 3212401 actccttccg agtcaggtga tgctaagttc actataaaca gagacagcgt gtttccttgt 3212461 gaactatgtc acacactctg cttttttcac aaaatgttca cacaaaggag aaggaaggct 3212521 gcgttcaggc aggacgcttg ggtcattagc tgcctttcat tcaaagatca aaaaaaaccg 3212581 gctctattta agaaccgggc tcagcgtttt catcctgtga tgtatgcaga taccgcaaaa 3212641 ataattgata ggaacaaaaa acattttgct gaagcatagc caaaaagttc atttgcagct 3212701 gcggatgata agacatcatt ttcttaaata tgtaatatgg gatgttgaga atcagaatgt 3212761 ctgaagtggc attgactgag ataaagggcg ataaataaag cccgcctttt tcatcaatcg 3212821 gaaacacatc gcctttttcc cacagcgcaa cggttttcga cccttcaggg agccttgtgt 3212881 ccataaaacg gacactgcct tttaatacaa tataaacaga ttgagaatga agaaaagatg 3212941 gagactgatc acatgaaccg cggataaacg tgccgttttt cagcaaggtt tcgacaatgg 3213001 atagaggcac ttcattaaac ataggaagtt gtttcagaaa taataaatag tcacactgat 3213061 tcataggaaa acctcctgtg ctaaggatag ctttagtgta gctcgactga gcctgtacag 3213121 cagtgatgta tttcacagcc tgtatgatga atgtcactta tcaggagggt gaatgcattt 3213181 ataatgaaag aaaaaaggag gatttcgatg aaggcgctga ttccgaagca gcacggggcg 3213241 tgggcgatgc tgctgatccc atttttactc ggcatggtca agggaggccc cgttatttgg 3213301 catattccgc tcttccttgg ttggcttttc ctatacttag cggtttatcc cgttacgctt 3213361 gccttaaaaa agaaacaaag caaaccatat caaaagtgga tgtgttatta cggttttccc 3213421 acctgctgct ttttgatgat ctcggtcttt cataagccgc ctctcatctg ggtgggcgtt 3213481 tctttactgc cgctgtttct catacatatg tattttgccc gcagaaaaaa cgaacgagcc 3213541 ttattgaatg atgttgcagg tgtcttgttc ttttgttcgg gcgggtttgc gagctgctgg 3213601 ctggggatgg gaacccttga cggctgggct tggtttattt tcttgcagtc tgctttattt 3213661 tttatcggga gttcctttta tgtgaaatcg gtgatccgcg agagaaaaaa cagggcattt 3213721 gcatactggt catggggata tcacctgctg ctcccctttt tatccgctct tttcggagca 3213781 ggatgggcgt ttctcgcttt tatcccgagc agcttgcggg catggttttt tcatggaagg 3213841 gattggcccg taaaaacgat tggcattctg gaaatcgtga atgcctgctt ctttcttgcc 3213901 gtcatgtgcc tgtttatcac aaggtaaaaa aacaaggaca ccgctgtcct tgtttttttc 3213961 agtcaatatt gcaaatctcc agcgggcaat tttcacactc aatctcacat cgtaaatagt 3214021 cccgcttgtg caaaataatt tttccggatt cgtctatcga aataacccct tttttgcgga 3214081 gatctccgag catacgattg acgctttccc gtgcagccgc gcaaaacttt gccaaatcct 3214141 gatttgtcag gacaatgtta atcagaatgc cgtcgcttcg ctccactccg tagctgtttg 3214201 ataagcggat aagggtagaa tagagcgccc cctttttgcc atgaagaagc agatccctga 3214261 ttttggactg aatcttccgg aggtgcgtgc tcatccattt catgaactca aatgtcaaag 3214321 cgccgttttg gattaattct ttttccagct tatttttatt aatgacgagc acctcgccat 3214381 cctctagtac ttttgcactg agcatatacc ttggttcttc agtgaaaagt gttaattctc 3214441 cgacgatatc atgcttttgg cagattctaa gcgtcaggtc ttttccgtca gatgtcagct 3214501 tgccgatttc aatgagtcct gattgaatca gataaagctc ttctgcatcc attccttccc 3214561 gaaacaaata cgtgtgtttt tccatttttc ttttcgtgct gatcgattcc agcaattcat 3214621 acagatcgct ggatataaga tcactatcag atggtcgaac agagagaaaa ttcatgagct 3214681 cacctcgaag aaagtcacgt tgtgtgttta ttgtaacgtg aattgatttg tacccatcga 3214741 gaaaaaacta acaatcttgt gaatgcccca gtgttagttg atgctctggc tgtttctctc 3214801 cgtgtgtgtt ttcattcttt cctgccaata catccatatg acaaggacaa aactggctaa 3214861 cgccacctct gaaagcgcca taaacccgat cgcgtactgg cctgttgcct gaaatacact 3214921 cgccaatatg agcggaggaa aaaagccgcc taaaccgccc atggcagaca caatcccatt 3214981 ggcaatcccc gcttgcttcg aaaaatagaa aggcaccagt ttaaaaacag ttccgtttcc 3215041 tatgcctgag cagacggcca cggttaatga tccaaacgta taaaggccga ttgtcggcga 3215101 gaacgatagg ataatgcctg ataatgtaag cccggcaaaa acaaacatca agatgcggag 3215161 cgggctcatt ttatcagcca ggaatccgcc cgcaggcctg agcagcgtag aaaccgcaat 3215221 aaagccagcc gtccgcaagc cggcatctgc aggattcagc ccaaaatgct ccaccagaaa 3215281 gttcggcaga tagatagtga aggcgacaaa ggcaccgaac gtaataaaat aaaacaggct 3215341 cagaaaccat agcacatgat ttcggtaaac agctttgatt tgagtcttaa cagaaacttt 3215401 gaccttcttc tcatgcctgt cgccaaacaa tacgtgcagt aaggcaaaga cagccagcaa 3215461 aatcagatac atttgcacgg ttgatttcca cccgacggct tgagcgataa ccggcgctgc 3215521 aaatgtcgta acggctgtcc cgatatttcc tgcaccgtaa atcccattga cgacaccgtg 3215581 cttttctttc ggataatatt tcgggaggga ggtcacccca atggaaaaca ccgctccccc 3215641 gatccctaag aaaaagccgc ctgcgattaa atcaaacaga gaatccgcga tactgatcca 3215701 aaatacagga aataaaagca ggatgaagct gaccataaac atgagccgcg cgccaaacct 3215761 gttcgttaaa taccctaaag gaatgcggag aagcgacccg aggatcacag gaatcgcggt 3215821 cactaaagaa atctcaccct tgcttaaatg aatatctaat gtgatttggg aaatgagtga 3215881 tgaaatcagc acccaaacca taaaccctgc caccaagctt aatgactgta acgataattg 3215941 aatgtgttga cggttgatca tttggcttgc ccctttcaat gattcaataa tcagtcttat 3216001 catacaaaaa ctagccaaac aggattgtga attacatcac acgtttttct cataaaaaaa 3216061 ggacaaagcc cgaagacttt gtccttttga tcgtgattac attttttccg gagccgatac 3216121 gccgatcagc tgaagcgcat tgttcagcgt aatttgcgtt gccttcatta aagccaggcg 3216181 cgcgcggctt ttctcttcat tttcagggtc gatgactttc tctgcgttgt agaagctgtg 3216241 cagagcagaa gccagatcat aaatatagtt agtgacacgg tgcggaattc gtttttccgc 3216301 tgcttccgcc actgcctctg ggaagccgcc gatcgttttc agcagatcgt attctttttc 3216361 tgattgaata tggctgaaat caagatctgc cgccggttta agcccctgct cttccccttg 3216421 gcgaagcatg ctgcaaatac gggcatgcgc gtattgtgca taatacacag ggttttcgtt 3216481 agatgttgat acagcaagat ctaagtcaaa atccatatgg gtgtctgcac ttcgcattgc 3216541 aaagaagtaa cgcacggcat ccaagccgac ttcttcaatc aggtcacgca tcgttacggc 3216601 tttaccggtc cgtttgctca ttttcatttt ctcgccgttt ttgtaaaggt gaacgagctg 3216661 aatgatttct acttcaagcg ttcctttttc atagcccagc gcttcgattg ccgctttcat 3216721 acgcgggatg tagccgtggt gatcggcgcc ccaaacgttg atcagcttat caaagccgcg 3216781 gtcaagcttg tccttatgat acgcgatatc aggaagaagg tacgtgtacg tgccgtcctt 3216841 cttgatcaat acgcggtctt tatcatcgcc gaaagtcgtg gaacggaacc aagtcgcgcc 3216901 gtcttcttca tagacgtggc ctttttcgcg gagcgcttca agcgccttgt cgatttttcc 3216961 attttggtac agtgaagttt ctgaatacca cacatcaaac ggcacacgga agttttccaa 3217021 gtccttgcga agcttttcca gctcgtattt caggccgtat tcacggaaaa acgcgaggcg 3217081 ttcactttcc tcttcgttaa cgaaacgatc accgtattcc tcagcgagac gctttccgat 3217141 cgcaatgata tcctcaccgc ggtagccatc ctccggcatc ggtttttcca atccgagtgc 3217201 ttcaaagtaa cggacttcaa cagaaagcgc cagattgttg atttggtttc ccgcatcgtt 3217261 aatgtagtat tcgcggctta catcgtaacc cgcttttgaa agcacgttgc acaaggaatc 3217321 gccgacagcc gccccgcgcg catgcccgag gtgaaggtct cccgtcggat tcgctgatac 3217381 gaattctacc tgaactcgtt caccgtttcc gatgttcgtt tccccgtatg cttcccctgc 3217441 ttccagtaca gacggaatca gctttgttaa atattgattg ttcatataga aattgataaa 3217501 acccgggccg gcgatatcca gtttttcaat cgaagccttc cctttatcaa aatgggcgac 3217561 aatctcttca gcgatttgac gcggcgcttt ttttgccact cttgccaact gcatcgccat 3217621 attcgttgag tagtcgccgt gtgttttatc tttcggtgtt tctaaaacaa cattgggaat 3217681 ctggctttct tcagccagtc ccgctttcag aacggccgct ttgatttctt ctttcagcac 3217741 gtccttcatt tgttccgcaa tgttcatgcg tgagttcctc cctcatacgt gatcgtcata 3217801 ttatgtaaat gctcctgctc gtctccgaca tgcatgtcat atgcgatgct gatacggcct 3217861 ttttcttcat cgagatcaga ttgaatcgat tttgtgcttg ttttcagctc aagctcacca 3217921 aatgacattt tatatttagc aattgtggaa gctcccgtta cgaaacgctg attcattttg 3217981 acagcgcctg acctcatgac caggacttcg ccttcgctta ctttcacaat cgttttgact 3218041 ttgcctaagt cgtgttcttc ataataagat agatacactt tattttgttt tacatagtaa 3218101 aatccggtgg tgcggaattc gatgacttct tggtttccgt catcctcgat cacagacttc 3218161 acatggagtg ttatcggtgt ctcttgcttc attctgacac gtccttttca tcattccact 3218221 ttgacttgaa tagtataatc attcggtttg taaacttcaa ctgcttctat cttaccatca 3218281 ttgctcatca gatttgaaga taaacctcat aaaaagcatt tccttatata gaagagaaaa 3218341 tcatatcact aattaccttt aggaaatgtt acgagctcgc tacatcgcaa tcgcagacgg 3218401 acccgcgcca accggaatca ccgtcacggc tgtataatca cttgtgcggt acacggtcac 3218461 agcattgtcg ttgggctgtg ccgcataaat atactgtttg tccggcgtta cggcgaggtc 3218521 aaaggcgccg gggagagaca cgtttgcaat gatcctctgt ctggccgtat taactacgta 3218581 taagttatta atgagaaacg gttcactata tggctctaga aaataagctc tagtactatc 3218641 gagagaaaat acaatcgtcc tcagcgtttc aaataaacgg ctgaagtccc ctcccctgct 3218701 taatggtgac aaactaatct ccgttacacc tttcggccac agctcaccat tcaatacgta 3218761 cgcaaaattt ccagcgtaag gagttgtaat taaactggga aattcaaatg tatctatgat 3218821 actttctacc aactgcccag tatttacatc atatttatca accgaccaac tgcttccatt 3218881 agcggtatag acatactgtc cattcggatc aagagcaaag tctaaagcgc cgggtatcgg 3218941 aatgacatca atgaccgatt gagaggccgt gttaatcaca tatatagatc cggcggccat 3219001 cacgtatgcg aactcatctg ttggatcaaa ttcgattttt ctcggccctc ctccaacagt 3219061 aatggtattt atgatggtta atgttttatt atcaatcact gagacaaggt tggtatttcc 3219121 atggaggaca tacgtgaatg ctttatcgaa agtaacgcct agattagttg gcacgtcaga 3219181 aaaagggatt gtttttacaa cagtgtttaa atctgcatca ataaccgaaa ccgtgctgtc 3219241 tccagtattg gcagtaaaca catacgattg agggtctggt gatggcggta aaacaagtgt 3219301 cccggccacc gtaagcggac tgccgtagaa aggcggtaca atgagcagat cttccactgt 3219361 tatttgactg aaatcaggac agcggccaga ctgtgctgca taataaacaa cttgatcaat 3219421 ctcttcagta tgaatcacag aaacagcccc gtctccttgt ccatattgat ttcgtacagg 3219481 cgacacactg acaagaagcg taatggtccc ttgtactctc acagcatatc gaacaccgat 3219541 atcttctggt tccggcccag tctggattaa gcaaggctca ctgatacagg acaaattgtc 3219601 tgtactccat gtaacagccg ctgacgcttc ggccgtatca accttgaagc cctcagggaa 3219661 atctatcggc acttgaaacg gcgcttcccg gctaatttcc tcatcacaaa aacagaaaca 3219721 attttcctgt aaagcagaaa gatcattctt tttcatgatt tcacgtcctt ttagaaatgc 3219781 acaacatgca gcggttaaat cgtaatggca cccggtgaaa ccccaagaga tatcacagtt 3219841 tcctcagaat aatcatctgt gttgtaaaca atgatgctct gctctataaa acgagttgca 3219901 tacagaaaat cgccattcgg ggtaaacgca tagtctgttg ctgattgcgg aacatttcct 3219961 ataacgcctg ctccatttgg actgacagaa tataaattgc cagtgaagcc gtcatataaa 3220021 tacacctctg ctccactcgt aaacattcga tattcccctt catactccag ctcttgggtg 3220081 ctgctgatgg taaacgtatt taaatcaata accgtcaaat aattaaaaaa gaattcttgt 3220141 tctaatacat aggcataccg ctccggccaa tttgtttcta tggttgatac gataagctct 3220201 cgttcaattg ttcctgtgac ttcaccggta gttaggtcca ctttttgcac tattccaaaa 3220261 ttcagaacat aggcgaataa cccattggga tcgattgcaa catcatatcc ttccacagga 3220321 atcgacctat ccacagttaa cgtatcaatt ccaatcacat aaaccgcagt accggtgaaa 3220381 acataagcaa actcatgatt agggataaat ctaatcaatc gaggcggctg atccagcaat 3220441 atagttgctg tcactgttaa tgtgtcataa tcgatgacag aaatcacatt attgttggga 3220501 tgtaagacaa acacagcgct tttatctggc gtaatttcaa tacctgccgg attgtacgga 3220561 agagcaatcg ttgtcacaac agtatcggtg tttgtatcaa tcacagaaac tgattgatca 3220621 tttggattcg ctgtaaacgc gtagacgggt tccggctccg gtacaagcac aattgtcccc 3220681 gtcaccgata aaggactgcc gtaaaacggc ggaacaacaa caaggttctc aatcgtgatg 3220741 tcactgatat ccgggcaatc atccgattca tcggaataat agacgacttg atcgatttct 3220801 gcattgtgaa tgacggaaac agccccgtcc ccttgtccat attgatttcg gacaggtgag 3220861 acactgacga gtagcgtaac ggttccctgc aggcgcactg caaattgaac accgacctca 3220921 tcaggctcag gccccgtttg aattaagcaa cggtcactga cacaagaaag gctgtctgca 3220981 ttccacgtca cgtttgcaac agcttcagcc ggatcaacga caaacccttc aggtaattca 3221041 atcggtgctt gaaacatggc ttctcggctt gcttctccct cacaaaaaca taagcactct 3221101 tcttgttctg ctcctgcttt ttctttaaag gaaagcttgt tttttctcat tccttcactt 3221161 ccttttcaga catacactgc tcacgcagat ataacagaat atggaagggt aacgtgtttg 3221221 cttgtacaaa ttgctgaggg taaacgcttc tttttgaaaa tatatctcca aacatgcggt 3221281 gtaacgaaag aaaaaattgc ggtttttttg cgcttctcac aagaatgttg atgataaaat 3221341 atgacatata tagaattatg aagggaggga tttgcaaacg tgacaggtgt catatcttct 3221401 tcttccatcg gagaaaagat taacgaatgg tatatgtaca tacgccgatt cagcataccc 3221461 gatgcagaat atttgcgacg agaaatcaag caagagctgg atcaaatgga agaagatcaa 3221521 gaccttcatt tgtactattc actgatggag tttcggcaca acctaatgct tgagtacctt 3221581 gaaccgttag aaaaaatgag gattgaggaa cagccgagac tgtctgatct gctgcttgag 3221641 attgataaaa aacaggctcg tttaactggt ctgcttgagt actattttaa cttcttcaga 3221701 ggcatgtacg agctggacca gcgggaatat ctgtcggcta ttaaattttt caaaaaggcc 3221761 gaaagcaagc tgatattcgt taaggatcgg atagagaaag ctgagttttt ctttaagatg 3221821 tctgaatctt attactatat gaaacaaacg tatttttcaa tggactatgc acggcaagca 3221881 tatgaaatat acaaagaaca tgaagcttat aatataagat tgctgcagtg tcattcttta 3221941 tttgccacca attttttaga tttaaaacag tatgaggatg ccatctcaca ttttcaaaaa 3222001 gcttattcta tggcagaagc tgaaaagcag ccccaattaa tggggagaac tttgtacaat 3222061 atcgggcttt gtaaaaacag ccaaagccaa tatgaggatg ccatacctta tttcaaaaga 3222121 gcaatagctg tttttgaaga atcaaatatt cttccttcct tacctcaagc gtatttttta 3222181 attacacaga tccattataa attaggaaaa atagataaag ctcatgaata tcatagtaag 3222241 ggaatggctt attcacaaaa ggccggagat gtaatatatt tatcagagtt tgaatttttg 3222301 aaatctttat acttatcagg cccggatgaa gaagcaattc aaggattttt tgattttctc 3222361 gaaagtaaaa tgttgtatgc tgatcttgaa gatttcgcta ttgatgtggc aaaatattat 3222421 catgaacgta aaaattttca aaaagcttct gcttattttt tgaaggtgga acaagtaagg 3222481 caacttattc aaggaggagt gagtttgtat gaaattgaag tctaaactat tactctcttg 3222541 tctggctcta agcactgtgt tcgtggcaac aactattgca aatgcaccta cacaccaaat 3222601 tgaagttgca caacgaggaa tgatttaacc gccgtccatc ggcggttttt tcgtcccctc 3222661 tttaccaaag tctcccaatc catgctatga tcttttcaat aatcttgaag agagtggaaa 3222721 tgcagcatgt ctctaaaaag tgtgagaacc cactttactc aatggaatcg agaaaatgat 3222781 gtgacggagt tcgaaacgtc gagtgcgaca gttgaacagg cagctgagac aatcggcgta 3222841 agcctgtcta gaatcgccaa gtccctgtcc ttcagagggg aaggagatca ggtgattctg 3222901 attgtggcag ccggcgatgc caagatcgac aacaaaaagt ccaggcaaac atttggcttt 3222961 aaagcaagaa tgctctctcc taatgaggtg ctggagcaga caggccatga aattggagga 3223021 gtttgcccat ttggattggc tcatgatcct gaggtttatc ttgatgtatc gctgaaacgg 3223081 tttcagactg ttttccccgc atgcggcagc agaaactccg ctattgaatt aacaccgaaa 3223141 gaattatccg aattttcttt ctcaaaagtg tggattgatg tttgtaaaga ctgggaataa 3223201 aaaaacatcc agacatcgtc tggatgttta cttatttcac aaacccaagc agcatttcac 3223261 ggatgatttt gctggctgtg tttgccgttt gctctgagtg gtcgtatacc ggcgcgactt 3223321 ccactaaatc agcgcccttt acgtttacct ctgaacgcgc aatttcatgg accgatgcaa 3223381 gcagttcttt agacgtgatg ccgccggcgt caaccgttcc tgtacccggt gcgtgtgcag 3223441 ggtctaatac gtcaatgtca attgtgacat aaaccggacg gcccgccagc ttcggaagca 3223501 cctctttcag cggttcaagc acttcaaatt ttgagatgtg catgccgttt tccttcgccc 3223561 attcaaactc ttctttcatg ccggaacgga ttccgaatga atacacattg tgcggtccga 3223621 tcaattctgc cgccttacgg atcggcgtgg agtgagaaag cggttctccc tcataatcaa 3223681 cacgaagatc tgtatgtgcg tcaaaatgga taatcgcaag gtctgggtat ttcttgtaca 3223741 tcgctttaat gacaggccat gacacgaggt gctccccgcc catacccatt gggaacttcc 3223801 ctttttctaa aatgctgtcc acgtactctt caatcatatc caggcttcgc tgcggatttc 3223861 cgaacggcag cggaatgtcg ccagcgtcaa agaagttcaa gtcagccaga tcgcggtcta 3223921 aatatgggct gtattcctca aggccgattg acacctcacg gattctgctt ggaccaaagc 3223981 gtgagcccgg gcgatagctg actgtccagt ccatcggcat gccgtaaaga atggcgtccg 3224041 cctcttccca ctcgggacgg ctcgcgataa atacttttcc tgaataagct tcatcaaatc 3224101 tcatctataa taccctcgct ttcctgtaaa aaagcgcaag attcgctcct gcgccatacc 3224161 ttcattattt aatcaggtca ctcacaaatt tcggcagaac aaacgccgct ttatgaatat 3224221 cttttgtgta atatttcgtc tcaatatcga agaaacggct gtcttccact gcaagcggat 3224281 catatttttt cgagccaatt gtaaatgtcc acaaaccgct tggatatgtc ggaatgttcg 3224341 ccgtatacag cttcgtaatc gggaagattt ccttcacgtc gcgctgtaca tttgtgatta 3224401 attccggtgt aaaccatggg ttgtccgtct gcgcaacgaa aataccgtct tctttcagcg 3224461 cttttgcgat tcctgcgtag aatccttttg taaacaggtt tacagccggt ccgactggtt 3224521 cagtcgaatc taccatgatg acgtcatatt gattttcaga ttttgcaatg tgcataaatc 3224581 cgtcatctac ctgcacgtca acgcgcggat catccagttt gcctgcgata gaaggaagga 3224641 actttttaga gtattcgata accttgccgt caatatctac aagtgtcgct tttttcacgc 3224701 ttgggtgctt caggatttct ctgataacgc cgccgtcacc gccgccgact acgagaacgt 3224761 gctccggatt tgggtgcgtg aataatggga catgcgccac catttcgtga taaacgaatt 3224821 cgtctttttc agatgtcatc accatgccgt ccaaaaaaag catgttgccg aactcttctg 3224881 tttccaccat ttctaaatgc tgaaactccg tttgttctgt atgtaacgtc ttgttaacct 3224941 tcatcgtaat gccaaagttt ttcgtctgct tctctgtgta ccaaagttcg ctcaattgtc 3225001 atctcccttt cgaggctgta ttcatttatt gtaagcgtct tatcagcttt tattctcggt 3225061 tgaaatctca ttttcaccta aggaaaaagt atagaggatg gcggggaaaa agtaaagatg 3225121 cgtcctgttc tgcgatgttt aaaaacgatc tttttttctc ataatagtag aaacataaaa 3225181 aaagggggaa cccgttgtgg atgcaatgac aaataaacgg ctgagactga cgctgaaaac 3225241 cgttcgcgcc tttatctttt taggggcttt tgcggccttg gcggcagctg ctgtgtttat 3225301 gactgtcatt ttgatagcca aataccaggg cgctccctcg gtgcaagtgc cgcaatccac 3225361 gattttgtac gcgagtgacg gctcaaagct cggggaaacg aactacggcg aaaagcgcta 3225421 ttgggtcccc ttaaaggaca tgaatccgac gatcgtaaaa gcgacagtgg cgattgaaga 3225481 ccagaatttc tacgatcatc acggctttga ttataaacgc atggccggcg cggcgcttgc 3225541 tgacctgaaa gcatttgcca aggttcaggg tgcaagcacc atcacccagc aatatgcgag 3225601 aaacttatac cttgaacacg acaaaacgtg gaaacggaaa tggaatgagg cgttctacac 3225661 gatccgtctg gaacaaaact attctaagga cgagatatta gaaggctatt taaatacgat 3225721 ttactacggc cacggcgcct acggcattga agcagcttcc cgcctgtatt tcggcaagca 3225781 tgccaaaaac ctgacggatg cggaggcggc gcttttggca ggaatcccga aaggcccttc 3225841 cggctattca ccgtatgtca atgagacgaa ggccaaggaa cgccagaaaa cgattgtgcg 3225901 gatgatggaa aagcagcaga tgatcagcca aaagaaagcg gatgaattga tcaaggaacc 3225961 tctttcctat cagcctttga ataaacaagt ttccaagaga aaggctcctt atttctacga 3226021 caatgcgatg agagagctgg aaaaaaagct cggcatgaca cgggagcaaa ttgaaacgag 3226081 cgggttaaac gtctatacaa cggtagataa acggatgcag cgcatcgccg aggagaccat 3226141 taccgaaacg gttaacgcgg gctctgacat tcaagtcggg ttttcagcca ttgatccccg 3226201 caccggaaac gttctcgccc ttgtcggcgg cagggattat caaaaaagcc cgtttgaccg 3226261 gacgacacag gcgaagcgcc agcctgcttc gacgatcaag ccgttgctgt actataaagc 3226321 gattcagagc ggatttacgc cagtcacttt gatgaaaagc gaagaaaccg agtttcaaat 3226381 tgatgcaaag ggagaaacct attctccaag caactataac ggatactatg ccaacaagcc 3226441 gattacgctt ctgcaggcgc tggcgctttc cgacaatatt tacgctgtga aaacgcatct 3226501 ttttctcggc acgaacaaac ttgtaaagac ggcaaaggaa ttcggcatta ccgcccatct 3226561 tcaagcactg ccgtccctgg cactcggcac cgaacccgta cgtccgattg agatggtcaa 3226621 cgcctatgcc atgctcgcaa atggcggaaa gaaaatcgaa ccgactttta tttcaagagt 3226681 aacggacgca gccggccacg tgctgtacga aaacccgaat cagcataaac aggtgcttga 3226741 tgaaaaagcc gcttttgtca cagcgagtat gatgacaggc atgtttgata tcgatttaaa 3226801 tggatatacg tcggttacgg ggcgaacgat agccaaccgc ctgacaagaa cgtatgccgg 3226861 aaaatcagga accaccagcg cagacagctg gatgatcggc ttcaatccga agctggccgc 3226921 cggtgtttgg accggctatg acaaaaacag caccatcgac tcggtcgaag aaaaaagcta 3226981 tgctaaaacc atttgggcgg acttcatgga ggacgcgctc aaaggcgaac cggaaaccgc 3227041 gttcaagccg ccaaaaggcg taaccggtgt gtacattgat ccggaaacag gctactcatc 3227101 aggtcccggc tgcgccgcta agcattacac atattttgtg aaagggacag aacccgcaaa 3227161 cgtgtgctac ggggcagaac ccgcaaaaca aacaaaagac cggcttccat ccaaagaaaa 3227221 gcccgcttcc gagaaaaagt ggtgggacaa atggctgggg cgacatcatt gaaaataacc 3227281 cggctcctcg gaggccgggt tattcgtatg gttccttcat aatcgatgga agaatgttag 3227341 acaatcgagc tgaacaatca gttttgggat aaagtggtga atttctcatt tcttcggcgc 3227401 tggctttcat ctcccagtcg ccgactcata tccccctaaa aatgaaaaac cccgagtctt 3227461 gtttcggctc gggattttcc atgtcctatt tctgtatcac cagtttactc aatgtttacg 3227521 aaaaatatct caaatacttt aaaagttcac aaaaaattca taaattaatt gttttctgga 3227581 agcaggctcg tttttaactc atctgaggaa cggtcccata ggccctgatc atgctttttc 3227641 agaaattcgc ctagtacacg cttcgagctg tcgtccattt tatcaacgat gattttccgt 3227701 ttcatggatt tatccatcag attcacatgc tcaggcagtg acttgtagcc tcttctgatg 3227761 cttctgtcga ccgtcatttc acaggctgtc acaccagcgt aataaggccc ctcttctttt 3227821 ctgtcaatcg ttacccacac aagccagtat ggttttccgt tcggcacttc ttctttattc 3227881 gggagaaatt taattccttt ttcaacggtg ctgcgggcat gcatagcgcc gatgtctacg 3227941 aacgcttctt tttcctctac atcaacgaat acgggagaaa tgttatcaag gctgagtgcc 3228001 cctacgccaa aaccgccgtg tccgtctgtc ggatcacttt tgataatatt aaacccgatt 3228061 gattttttct ttttttcttc catgaagttc tacctcctac aaaagcggtt gaaatatcgc 3228121 tgaaaacagc tttaaaatcg aatctcttcc tgcattgagc atcggccaca gcacgtaaga 3228181 tcctagcggt gtcacaaaca gcaccaaaaa tacgataaag ccgtagctct ccgcctgcgt 3228241 cattttggca cgcacgcccg gcggaacgag atcttctata attcgatagc catcgagcgg 3228301 aggaagcggc agcagattaa ataaaaacaa gacaagattc agctgtatcc aaatagaaaa 3228361 aaactgatcc agccccgtgc tgaacgccgc aagcatttcc attccgtacg catgcatcaa 3228421 cactaacaaa aagaaaccaa taaacgcaag aatcaggtta ctgacgggcc cggctataga 3228481 tacgagcaca ccagcaagcc ggggtttctt aaagaaacgg cgattcacgg gaatggggcg 3228541 cgcccacccg aatccggcca ccagaatcaa aatggttccg aacggatcaa ggtgtttaat 3228601 gggattcagc gtcagtcttc cttgtttttt cgccgtatcg tcaccgaatt tgtatgcgac 3228661 ataagcgtgg gcaagctcgt gcatcgtaaa cgacacaatt agcgtgatga cgaggtatgg 3228721 cattaaagat aacggataat ataaaaaacg gtccaagtga gatatccctc tttctcaaaa 3228781 tgcaagaatt tactttattc agtatactat aagaagcctc tttttctaaa gagaggaaac 3228841 gagataaagg aggattcagc acccatgcca tacgtaactg tcaaaatgct cgaaggccgt 3228901 acagacgagc aaaaacgcaa tcttgtcgag aaagtaacag aagccgtaaa ggaaacaacc 3228961 ggtgcttctg aagaaaaaat tgttgtcttt atagaagaaa tgagaaaaga ccattatgcc 3229021 gtcgcaggca aacgcctgag cgatatggaa taatctctat aaagccggcg cttcgcgcac 3229081 cggcttttat tatccctatt gagccagctt cgcaataatc gccaagaacg tctttttctc 3229141 ttcggctgtt aaacgttcaa acatgccatc aatcagctgc tggcggtttt cgatcatttg 3229201 ttcagccgct ccccggcccg attcagaaag agtaatccat acagtgcggc ggtcattgtt 3229261 atttctggat ctctcaataa acccttcctg ctctaaatga ttcagagctg tggtcgtggc 3229321 agagggagac agtgtgacct ccttcaaaat atcctttatg gtgcagctcc catgtctgta 3229381 tatgatccgc agaataaacc ctcttacatt attcacgtgt ttcggaacgg tggcttcatc 3229441 taattgcttc gtgcttttca aatactttgt aagtgcgtga tccagcaaat ttgcttccag 3229501 tttgtcatgg tccatgtcaa tttccccatt tcgagatgca ttcataacat acgaacgata 3229561 tgatttactt attattttac tgattccgaa tagggaaagt caaaaaagca aaatgtgaat 3229621 tcacagcttt tatcctacat gcctcgattt tccacctgtt tcacaagttt atctttaaaa 3229681 gtttggaaag gaacgtgttc attctgctga tgtccgaatc ggcggacgtt taccgcattc 3229741 tcctgctcct catgatctcc aagcaccagc acgtacggaa ttttttgcac ctgcgattct 3229801 ctgattttat agccgagctt ctcattgcgc tcatcaatgc cggctcttat ccccgcctgc 3229861 ttcagctccg cctgcacttt tctgcaatag tctaagtgaa cgtgcgaaac cggtatgatt 3229921 tgaacctgga tcggtgcgag ccagactgga aaagccccac cgtaatgctc gatcaaaatg 3229981 ccgaagaaac ggtcgattga gccgaaaacc gctctgtgga tgacaacggg acgaaccttc 3230041 tcattgagtt cgttgatata tgttaaatca aatttttccg gcatttgaaa atcaagctga 3230101 attgtcgcgc attggtggct ccgtttcagg gcatctttta tatggaaatc aattttcggc 3230161 ccgtaaaacg ccccatcgcc ttcattgatc tcataagaga ggccaagctc ctcaaggacg 3230221 cgtgctaagg cacgttccga cgcttcccaa aggctgtcat cgcctaatga atcctccggg 3230281 cgagtcgaaa gctcaacaga atactcgaaa ccaaatgtcc gatatacctc atcaatcagc 3230341 cgaatcgctt ctttgatctc actctcaatc tgatcctccc gaacgaaaat atgggcgtca 3230401 tcctgacaga acgtccgaac gcgaagcatt ccgtttaaag cgccgctgta ttcatggcgg 3230461 tgcacctgtc cgaattccgc catgcgaatc ggcagatccc gataagaata caggctgttt 3230521 ttaaagatga gcatgtggcc ggggcaattc atcggcttca ttgcgaatct tgtatcatcc 3230581 acttctgaaa agtacatatt gtcgcgataa tggtcccaat ggcctgactg ctcccataac 3230641 cgctgattca tcataaacgg cgtacgcacc tcatcgtagc cggcatttgt ttgcagctca 3230701 cgcgagaagc gctccagctc attgcggaca atctgccctt tcggcaaata aaacggcatc 3230761 cccggcgctt cttcagaaaa cataaacagc cctaactgtt tgccgagctt gcgatggtct 3230821 cgttttgccg cttcttctag catatgcagg tgcgcatcca aatctttttt cttttgaaac 3230881 gcaaccccgt acacccgctg caggacttca tttttgctgt ctccgcgcca ataagcgcct 3230941 gatactcttg tcagtttgaa cgccttgatc atccctgtag aaggaagatg cggccctcgg 3231001 cacaggtcaa cgaattcccc ttgctggtac agtgtgatat cctccccgcg cggaatatcc 3231061 tttaaaatct caagcttgag ccgctcgtct ttttgtgcaa acagctcttc agcttcttcg 3231121 taagaaacct ctatacgttt gatttcaagg ttctcattta ttatgttttt catttctttt 3231181 tcgatggcct ctaagtctcc tgatgccaag cttttcccca gcttcatgtc atagtagaag 3231241 ccgtctaaaa tcacaggccc tacccccaat gacacttcgc cgtacagccg ttttactgct 3231301 tgggccagca cgtgcgctgt tgtgtggcga agcacctgca agccttcttg tgaatcgagt 3231361 gtgacaatcg aaagctcagc atcctcctcc agcttgaaac tgagatcaac aagcttgccg 3231421 ttgacctgac ctgcggccgc cttcttttgc agactggaac tgatcgaacc agccgcttct 3231481 ttgattgtga tgcctttcgg atattcctgg atctgtccgt ccggaagctg aatgtgtaca 3231541 tgtttgctca ttttagaaca ctccttattc attgttgtat ataaaaaaac acacccgtcc 3231601 cgcagatagg gacgagtgtg tgattaaccc gtggttccac ccaagttccc gacaaatact 3231661 atgttgtcgg ctcggtgctg taacgcagca tagacggcat tggttacttc agttccccaa 3231721 tgctgctcca aggcggtaaa tgatattcct aagctgggaa gctctcacct ttccttccct 3231781 ctctgaaaac cgtaactatc attcatgtcc ttttcatcgc atgtattcaa ttcataaaaa 3231841 aacacacccg tcccacagat agggacgagt gtgtgattaa cccgtggttc cacccaagtt 3231901 cccgacaaat actatgttgt cggctcggtg ctgtaacgca gcatagacgg cattggttac 3231961 ttcagttccc caatgctgct ccaaggcggt aaatgatatt cctaagctgg gaagctctca 3232021 cctttccttc cctctctgaa aaccgtaact atcattcatg tccttttctt cgcatgtatt 3232081 caattcaaat aaaaaaacac acccatccct ctaaaaggga cgaatgtgtt gatcatccgt 3232141 ggttccaccc aaattcccga tcaattacac atgatgatcg gcttaaagat gctgtaacgc 3232201 agcatgacgg tatcagatac ttgttttccc tgatacggct caaaggcggt aagctgcttt 3232261 ccctgcgtta ggaagatctc agctgtcctt ccctctctgg aaaccgtaaa aagcatctcg 3232321 tgtccttatc agtgcctgtt gtttcaataa ttttttatat cttactatat attcccacaa 3232381 agcgcaatca gtgatttaca ttttttctga cgcggcagtc ccgttatggg cagccagaaa 3232441 cagccataca agcaatgcag cgaggctgta tgccgctccc atcatcaaaa acgcaaaccc 3232501 ggcaccagca taccaagtgg cggacagatg aatgatcacc ccggttatcg ctacgccgac 3232561 caaggctccg atttgccggt ttgcatttaa cgccgcaccg gcgatattcg tatgtctttg 3232621 cccggcagcc tgcatgatca cagttgtcat ggcaggaact gtaataccgg tacagaggtt 3232681 cataacagac atcaacaccg ccagctgcca ataaggaaaa tccggagaaa tcagcacaaa 3232741 caacagcaat gcaatgatac agctgaccgc cattgataca aacataagct gaccggcttc 3232801 aaaccgattc gccagacggg caaacagcag attgccgatc acgaagaccg ccatcatcgg 3232861 cagcagctcc actccagcca taaaggaact tgcccctcct gcttcctgca aaaaaaggct 3232921 gagcataaac atgccgccaa aaagggcgaa attcagcaaa aacccgataa attgggcagc 3232981 tgagaagcgg ccgtttttgt ataaggacgc cggcaggatg ggtgtttttg cagaaatttc 3233041 ccgcagcaaa aacagcacaa atgccaaaac cgctgcagta aatgctacaa gaatcactgg 3233101 cgagcgccag cccgctgaag gcccctgtat caaagcatag gaaagaaacc cgagagccat 3233161 catgccaagc agatgcccga tgatgttcac gcggctgctt ttcccaggaa cgcggctgag 3233221 gattcggtaa gctgaaatga gcgcagcagc ccctattggc acattgatca gaaaaatact 3233281 ctgccagccc gccaactgta ccagcacgcc cccgataaaa ggcccaaggg ctgaagcggc 3233341 ggaaacaagc gcggcccaca gtccaaacat tctcgcccgc gcccgctcat caaggtaaga 3233401 ggcagccaaa aggctgagtg agcttggcat aaacaaagct gccccaattc cctgtatgag 3233461 acgtccggca atcagcatct gcccatttat agatgcagcg catagacagg aggccataac 3233521 aaaaacggct agacccaaga tatagatcgt cttcgagccg aaacggtcag ccaaggctcc 3233581 gcccgccagc agaagcgacg caaaagtaag aatgtacccg tccacaaccc acgttacacc 3233641 tgaaagtgac attgaaagag tgtttttcat atcagccatc gccacattca caacggtcac 3233701 atcaagagtt gccatgagga aaccaagtgc gagcacgatc agcacggata tgcctgttga 3233761 tgatgttgat tcttgtatag acccgctatt tttcattaca attgcccttt cacttgcttg 3233821 attacccaat catctatttt ttcaagatca tacaattccc cgactctgtc cataacatgc 3233881 tgcaaggatt cttctctcat aagattggac catttatcct cgatttccgc catgactgtc 3233941 tccagcacac agtgactttc accctcaaat acagattgca gcaagccttt cccctgatac 3234001 atcgaacctc tgccttcgac cgcttgataa acatcataaa gcgtaatgtc agccaaaggc 3234061 ttcgtcaggg taaaaccgcc cttcgtccct ggtaaggatt ctgccaaacc ggcttgaacc 3234121 aatgttctca tcagcttctt caagtaagac ggagacacgc gcaatcgctg gcttatagcc 3234181 tctgacgtca aagaagcctg taccggcagc cgtgacagta acagcagcac agaaaccgcc 3234241 tgctccattc ctgatttcat tttcatccta ttcactcctg attcattatg gataactatt 3234301 atccataatg aatctcttag cagcttttgt caataaaaaa agcaaaagaa acggatcatt 3234361 tcttttgctt ggtatggtta acaaatctgc ttcagttcct ctatgtattg aagcgcttcg 3234421 tcatattctt catttgtata tttttgcttg cttttgatgg taaagacttt ttctttcttt 3234481 tcctcatcct caagcccgtc aaagtaaagg atcgtggaaa ccagctctaa aaaccgtgat 3234541 gaacggctgt ttacactgtc gatatagcct ttcatatccg gcatgtccag atcagcatgg 3234601 tctaaaaatg cggagcctgt ctcagtcagc gaataccggt attgaaagta gccgcccttt 3234661 ttttccttca cctcatgcag aaatccaagg ttgcacagct cttcaatctg gagcgtcagt 3234721 tcctctgaat atggtccgta aaagtgaaaa tcatatttct catagaaagg aaactgcatt 3234781 ttcttggcga tataaatcat tttctgcagc ttctttcgcc cgatgatttc tccagaatcc 3234841 gagaacacct tcatcagttt tgcatgttct ttcaacaaat tcccgacatc tcctttttcc 3234901 ttctttccaa tttctatgtc agtcccagca gctgccggat tttcattttc gcttccggat 3234961 gtttagtgcc gtcacaaatc aagtcctttg gatagtacag cttgtggtcc gtccgccgtt 3235021 tacctgagat ggattccaca atagccgact gtctggacag ctctttaatt tggccgtttt 3235081 gcgtcaagag atggatcggc agacgctcct cttcctctcc tggtcggtaa aaatcgtatg 3235141 gcagatctga tgaagaatca acgaccaaat aatagctcgg atcgatcccc gcctctttga 3235201 acaatgaagt cagctcaaaa taagccgaca tttcttcatt cggattgaat tcaacgtatt 3235261 ggaaaagctg gcggttaatg aatctgcggc acaagtcgga taaaatcgcg tcttcttcat 3235321 cctcccaggc ctggaagtaa tacaaaataa tagattcatc cagctttaca taatcctcca 3235381 gtgtcaattt tccttcaaaa atagaataga aatgaaccgg agcgtgagtg aagacatagc 3235441 cttcatcgtg cagctgcttc gccctgtgaa gaatcttcgt taaaatgacc tctgcacttc 3235501 tagtcacagg atggaagtag acctgccagt acatttggta acggctcatg atatagtctt 3235561 cgacagcgtg cattccgctt tctttaatga cgatctgatc ctcgcgcggc cgcatcaccc 3235621 gaagaatccg ctccatatca aaatggccgt agctgacgcc cgtataatat gcgtcgcgct 3235681 ggaggtaatc catgcggtct gcgtcaatct gactcgaaat caggctgacc acttgcttgt 3235741 ttttatatgt tttggcaatg acttcagcaa catcctgagg gaaacccggg ctcacctttc 3235801 tgagcacctg attaacctcc gtgtctccca aaatgatacc tcttgtaaaa tcctcgtggt 3235861 caaggtgaaa gaccttttca aatgaatgcg agaacggccc gtgcccgagg tcatgaagca 3235921 gcgccgcggc caaacagagt tcgcgctcac tgtcatccca ttcagggcgg cctttaaaga 3235981 cgtcatcaac cattcttctg acaatttcat agacaccgag agaatggttg aaccggctgt 3236041 gctcagcccc atggaacgtc aaataggtcg ttccgagctg cttaattctg cggagacgct 3236101 gaaattcacg ggttccgatc aaatcccata tcagcttgtc ccgaacatga acatagcggt 3236161 gcaccggatc tttaaacact ttttcttctg ataattttcc atttggatac gccatcgtca 3236221 ttccctcttt tttttagccg tgtttctatt atatcgactc tattctttga aaacatcctt 3236281 gaatttgccc ggcgatttgt tccatcttca tgaaaaacac atcttgtgaa gcaaaaaagc 3236341 ctgacctgag ggccgaggct aagaaaaaat atgtttttac ttttttattt tcttttttac 3236401 tttgtcaatc agctcatcct ctgtcggagc tgacagcggg cgattgttca caaaagcaaa 3236461 tgattttttc cgtccgggcc cgcaataaga ttggcatcct acctcaacct ttgcgtccgg 3236521 gtccacttct ttcaaacgcg gcagcaatgt tttgatatta gtggcttggc aatcatcaca 3236581 cactcgaaat tcattagcca tgacgtacgc ttcccttcat ttctatgttc atctatgtga 3236641 ataacctaaa atcacgtttc aaaaaaaatc acatcacact tcattttaca aggattcgac 3236701 tgttcctgca agccgctcca tccttcgtat ctcctattct ttcagccaat ttgtataaat 3236761 attttccaac ctggacattc taataccatg aaaagaaaaa tgggagttga gataaatgac 3236821 aaaacagcga caagacgctt ggtcagagga aaacgatctg cttttagccg aaacagtgct 3236881 tcggcatgtg agggagggca gcactcagct gaacgccttt gaagaagtcg gcgataaatt 3236941 aaaccggaca tccgcagcct gcggattcag atggaacgca gtggtccgcc atcaatatga 3237001 aaaagcgctt cagcttgcga agaaacaacg aaaacagcgg atgagagcgc tcggaaacgg 3237061 gcagcccgcg aaaaaaagat tattatatca gcctcctgcc gttgatcctg aaatcattca 3237121 agaaaccgct gcagaagagc cggttaaaac ggaaacacca tctgtcgaaa atgagcaacc 3237181 tttaatgtct ggcgaacaca tgccttttgt tgatgaaagc tttaaggaag agttagctag 3237241 tctatcacac ttattgtctc ctcaaacgcc tgcagctgcg cctgagatga cgatgaatga 3237301 tgtgatccgc ttcctgcaga attacgaagg caatcacgag caatcatcag cattaaaaat 3237361 ggaaaacgag cgtttaaaga aagaaaatca ggaattgcaa aacaaaacag agcagctaga 3237421 ggcagaagtt caaaagcttg aaaaagacca aaaaacgatc caagaagatt atgaaacctt 3237481 ggtgaaaatt atgaacagag ccagaaagct agttttattt gaagaagatg aacatgcctc 3237541 tccgtccttc aaaatggacc ggaacggcaa tttagaaaaa ttagcggaat gacatagaaa 3237601 aatcccaaaa cgggcagctg ttttgggatt ttcgccatgt gcaaaatccc cttttctatt 3237661 gagaaaagag aatttcctca ttttgcagcc ggatcagcta ttcttgtaaa atgaggccaa 3237721 gcttatgtga atctattaag acatgtgagc tgcctcggcc gttttttgtt tccgaggcgc 3237781 agcagaaatg accaaaagcc ccagcatcat aagcgcaatg cccagccacg aggaaggcga 3237841 aagcatttcc cctatgaaaa acacgccaag caatgaagcc gtcagcggtt cagctaaaga 3237901 cagcgtgacc gccgccgagg ccggaacccc ggtaagccct ttcgcaaaca aaaagtatgc 3237961 ggcacatgtt gcaattaacc cgatgtaaag gcttgttccc agtcctctag gggtcaatat 3238021 ccacgagata tctaactgcc ataatagcgg cgtcagcaag atggcgctga tcatgaatac 3238081 aacggcggag gtcgctcgcg gaggctgggt tttcatcatc gctttactga tgagcgtata 3238141 gcctgcaaaa gaagcacccg ctccaagcgc cataagaaca ccagccacat caatccgaac 3238201 attggaactg tcggaaaaca gaagccagca acccgctaaa gccagcacag tcgcaatcca 3238261 ccaggagttt cgcgggcgtt tcttcaatac agcccattcg agggtcccgg caatgatagg 3238321 cgcactgccg atggcaatca cagttcccac tgcaattccc gtttctttaa ccgctgtgaa 3238381 aaacagcggc tggtaacacg ccatacaaac agcggctaaa aatacgagcg gccatgccca 3238441 atttttcacg tgaagctccc ggctgatcca aaccgcaagc agcatggcgc ttcctcctat 3238501 taataacctg aacgctccaa atgccagcgg tgtggcgctt tctggagcca atgcctgaac 3238561 ggttcccgtg gtcccccaga aaaaagccgc aatcaataca aaaaggctgt aaatattccc 3238621 cttcatctgc ctctcccctt taatatggat gctgatgtca ttttatcgtt tttctttttg 3238681 tcgtggttat ctgtatgtaa gaaggactta tctgaaaata agattattga ggtaaaatgc 3238741 cgcttgagat aaaaaatgca tgccggcata tacagccggc atgcgaagaa cgttcaccca 3238801 aatacctttg cattccgctc agccatccgg acgaggtttt tctcaaattc catttcctca 3238861 tcaatggaca gtccagctga ataaagatgg gtgcttaacg cttttaattc cgtcaataaa 3238921 gcgaacatta agtcttgtac ggagatgtct ttttgaagaa gctcacttaa ggacgccatc 3238981 gtttccggac gtatttccgg atagacgcct tttttatcgt tttgtttgtc tttcagcgcc 3239041 gcttgataga atcgtctgat caagtcggcc ctttcactgc cgcttttatc tgcacagaga 3239101 taaatttgaa cagcgactcc gccgcgaacg cgtctctgag agatgccggc gaactttttg 3239161 ccatttatac tgaggtcata gctgccggga caataagacc cttcaatttc ataggcttcg 3239221 atctttgcgt tgtacggtct cagcattcgt ctcatcagct cgaccatcgc ttcatatcct 3239281 ttgtctatat cgatgccttt cttttcgtcc tcgaatatga gagagatatt taaaacaccg 3239341 tcatccaata cgacggcaag accgccggaa ttgcgtacga tcacacggta tccttcgctc 3239401 tccagcaagg agataccatc ctgcaaaaac gggaggcgtg tatcctgtat tccaaggaca 3239461 attgtatcgt ggtgcaccca tgagcgcgct gtcgccggcg acacgccttt tccgacggac 3239521 atgcatagcg tatcatccat tgcgaaggat tgcttcgcat caaataaagg gccgagactg 3239581 gattggtcaa tgactctcca tttcggctgc atcagtaaat caatcggttg gtttgccatc 3239641 tatgtaaaac cctttcatgt taggcttatt gaacgaaaac tattatatca tttcagcagc 3239701 tgtgattgat aattgctttt cagcatcgta ataaaaattt ctttattttt tgtattctcc 3239761 atgagaggag aatgaatgta agacagcttg cgctttaacg agaaattatt aatatgcaga 3239821 attgaaattt cgcggtggat caaatcctta cgcagcacgc ttctggatag aaccgaaagt 3239881 cccatgccgt taatcaccgc ttcctttaca ccttgattgc tgctgatggt aaacattgat 3239941 ttcggccgaa gtccatttga actgagtaca tgatcgagat attctctcgt cccggagcct 3240001 ttctctcttg tcacccacgc ttcgttctgc aaatcgctga tcgaaatctc tttccgcccg 3240061 gcgagcggat gctgatttgg agcggcaatg cacatttcat cctccatgaa cggttcaatt 3240121 tccagctcat tctcgtttgt atgtccttca atcagcccga tatcagcctg aagcatccgc 3240181 acacgctcgc tgacctcctc tgtattgcca atcatgacat ctagattcag ctctggatac 3240241 agcttttgca gctgggccaa tagcggcgga agaatatact caccgattgt aaagcttgca 3240301 gctattttca attcaccctt cacatagtga tgatgcgcat agatttcagc cttggcttgt 3240361 tcgtagagaa acaccatttg ctttgctctt tgatataaaa tgtctcctgt cggcgttgtc 3240421 gtaaagtgtt ttggcgacct gttcagaaga gccgtttgaa attctttctc aagatttttg 3240481 atatgcagac tgacgctggg ctgggagatc atcagctttt ccgccgcttt tgtgaagttt 3240541 ttttcttcta ccaccgctat aaacgttttc agcacgtcgt aatacaaaaa ccccacccct 3240601 gtcattaatg aaatatatgg ttatgattag ttttctttat tgtactcata tcatccgtct 3240661 tggtaaagaa gggctataca gaagcgcaaa aaaggcagcc ctcggtcgag agctgccatt 3240721 gtcttcaatt ttattacagt gcttgcgccg ctgtaattaa tgcgagattg taaacatctt 3240781 cagcgttaca tcctcttgaa aggtcgttta caggcatatt taaaccttgc aggattggtc 3240841 ctaccgcttc aaagttgccc aaacgctgag cgattttata gccgatgttt cctgcttcaa 3240901 gacttgggaa tacgaatacg ttagcgtccc ctttgatctc ggaatccggc gcttttttct 3240961 cagctacaga tggaacaaat gcagcatcaa attggaattc gccgtcaagt gtcagttcag 3241021 gcgctttttc tttcgcgatt ttcactgcat ccgctacttt ttctgtttca tcagattttg 3241081 ctgagccttt tgtagagaag ctgagcattg ccacgcgagg ctcaatgtcg aacatttttg 3241141 ccgtattggc actttcgatc gcaatctcgg caagatcttg gctgtcaggt gcaatgttga 3241201 tcgcgcaatc tgcgaatacg tattgctctt ctccgcgagc catgatgaac acgcctgaag 3241261 tctttttcac gccttctttt gttttgatga tttgaagagc cgggcggaca gtgtcagcag 3241321 ttgagtgagc agctccgctt acaagtccgt ctgcaagtcc tttatacacc agcattgtac 3241381 cgaagtagtt ctcgtctaat aatgctttac gagcctgttc ttcagtcgct ttgcctttgc 3241441 ggcgttctac gaatgcttgt acaaggtctt ccatgccttc atatgtatga ggatcataaa 3241501 tcttaacgcc gcccagcgta aggttcaatt cttttgcttt tgcttggatc tcattttcat 3241561 tgccgatcac aatcggattc agcactttgt ttcctgcaag cttgctgacc gcttctaaaa 3241621 tacgctcgtc taagccttca ggaaatacaa ttttaacgtc ttttccagct actttttctt 3241681 gcactgttga aaataaatct gccacaataa aacctcctca aaaagttaca aaaacgcttt 3241741 cttttactag catactcttc ttccaatcaa attcaaacag ccaactttca ttatagcgct 3241801 ttcataaaaa aatcttattt ttctaactaa tttaagtgac tcaatcttcc cttataggtt 3241861 cttctatttt gatggagtta tacggaaggg atgttcaagg tttctccaca gtagaatcgg 3241921 ataaactatg gtatagtgaa ggcaatcatg aaaagataat gggagtgaag ataaatgagt 3241981 gaacagcaaa tgacgaatga agcggcaaaa acgcttgacg gctggtatgc gcttcatgat 3242041 ttccgcacaa tggattgggc ttcctggaag cttctgtcca gtgatgagcg ccaatctatc 3242101 atacatgaat tcaccgggtt gcttgaaaaa tggggcgtag cccaaaaaga aggaaaagga 3242161 tcgcaaactc tttacagcat cgtcggccaa aaagctgatt ttatgctgat gatccttcgt 3242221 cctacaatgg aagaattaaa tcaaattgag cttgaattca acaaatcaag acttgctgag 3242281 ttcaccattc cggcatactc ctacgtatca gtggtagagc tgagcaacta cttggcaagc 3242341 ggtgacggcg atccttatga aaatccgcat gtgcgcgctc gcctttaccc tgaactgccg 3242401 gaatctaaat atgtatgctt ctatccaatg gataaaagaa gatctggcaa cgacaactgg 3242461 tatatgcttt caatggaaga acgcagaaac ttgatgagaa gccacggttt aatcggccgc 3242521 agctatgcgg gcaaagtcaa acagatcatc accggctctg tcggctttga cgattacgag 3242581 tggggcgtta cattatttag cgatgatgtc cttcaattca agaagctagt gtacgaaatg 3242641 cgttttgacg aagtcagcgc tcgctatggc gaatttggtt cattctttgt cggcaatcac 3242701 ctttcgcttg atacacttcc tcaattctta tatgtataat atccccgagc tcgtttattg 3242761 agataaggac tgatcggcct tctgctcaag tttgccgtac tttttatatg cgaatacact 3242821 gagcacaaat ccgaggactg tgatggcggc gcaaatcaat ccgacagctg catagccgta 3242881 tgccacatat acgggtccca ttaaagcaga acctaatgtc acggccagat tcgaggcgag 3242941 actgtaaaac accatgactt ttcctcgatg acgctctgag cagtcactca aaatggtgct 3243001 gagcagcgtc accgtcaaac tttgcattaa tccccaaata aataggctgg cgattaacag 3243061 aaacatagac gccggcgcat atggtaaaca cgccagcaga acgctgatga cccccagcgc 3243121 aatcaaaagg gagcgcattt ttccgatgcg gtcggctatc tttcctgtaa tcacactcat 3243181 ggaaaacccg attccataaa tcatgataaa taagcccgca gccgtgtttc ctccggtaaa 3243241 aacgtcctga agataggtgc ctaaaaagga atacataccg taaaaaccaa tcatattaca 3243301 aaaggttatt gtgatataaa caggtacacg agggactttc agcgcatccc ggaatgttcc 3243361 tgcgggctct tctatttctt ccttgccgct gtttttatgt tgggcatggc ggcgcatttc 3243421 aaggagaatc agcagaacaa ctaaaacacc catcagggcg aaaatccaaa acgtccatct 3243481 ccaatgcagg acgccgccga taaatgatcc gagcggcact ccgaaaatca gcgccagcga 3243541 ccagcttgaa acgatcagtc ccatcacctt gccccggtat gtataaggaa cacgatcacc 3243601 gacaactgcg taagcggtcg gaacaaacgc tcccgcagcc aatcccgaaa gcgcccggcc 3243661 taaaaagaag aaaaaaatat tttgagctaa agcgcatatc accgttccta tgataaaaat 3243721 cataagcccg gccaataagc tcagttctct ggagtattta tcgcctaatg gaaccaaaag 3243781 cggcgcaccg ataaaaatca taacgccgta aatactgata gataacgcaa ggacgctgac 3243841 atctgagctg aaggcttttg ctaaatccgg cagcagcggt gagatcacaa gctcttcaga 3243901 tccggctgca aataccccca tcgttaaagc cagtgccaac aataacggaa aatgatgttt 3243961 tgttttgatg tcattgtttt gattgctgtt cattctttct caaacacctc ttccataatc 3244021 ttcttatcat aaagttgtat tatagtttag cattgttttt tctctattta caattcgaac 3244081 gaaatattta taagttttat tattttcatt taaatcccat tatatatttc tatatttcat 3244141 tctaaaaata catgaggatg taacacgtaa aaaaagctct ccggcctccc ggagagcttt 3244201 ttctattgcg cctctgtctg ctttttttca atcgtttcat gatttatacg ctttttgatg 3244261 cttagatgat agtatgcata acagaaaata atgatcggca caccgcagta taagccaatt 3244321 ctttgatccg gaatgaaaat aaggctgatc aacacgcagc catataaaca aaatccgaga 3244381 atcgggacta gcggataaag cggcgttctg aactccagat cattcacatt tccgccttct 3244441 gccaggaaac gcctgcgaaa gaaaaattgc gacgcacaaa tggacatcca cgcgacaact 3244501 gtcaccatgc ccgagattga gatacaccat aaatacactg tttctgcagc catgacactt 3244561 gtcagcagcg aacagcctga aatgcctagc gtaatcagca gggcattcat cggcacgcct 3244621 ttttttgtca gtctggtgag aaaggaggga cccatttgat ttgatgaaag tgaccacatc 3244681 atacgcgacg ccgcatacaa tcccgaatta gcaacagata aaatggccgt taagatgaca 3244741 aagttcatga tatctgccga aaatgggatg ccgatttgat cgagtactgc tacaaacggg 3244801 ctttcaatca cccccgccgt tttgtacgga aggatggcaa ccaagacgaa catagcgagc 3244861 acaaagaaaa acagcgtgcg ccaaataaca tttcgaatgg actttggcag tgttttttcc 3244921 gggctttcac tttcccctgc cgcaatgccg acaagctccg ttccctggaa cgagaagttt 3244981 accatgacca gcgtaaacat aacggccagc accccattag ggaaaagccc tctatcagtc 3245041 ataaagttag acaaaaaggg tgtctcctgt ccgcctttaa agtcaatcaa gccaaacaca 3245101 gcggctccgc caatcacaat aaataatatg atcgccgcca ctttgatgct tgaaaaccaa 3245161 aattccattt ccgcaaagct tctgacagag agcgcattaa tcaaaaagat gacgatgccg 3245221 aacacgaggc accatatcca gatcggaacg gagggcagcc acctttgcat caaaatgcct 3245281 gctgacgtca gctctaaccc tactgtattg gcccagctga accaatacag ccagccaatc 3245341 ataaagcctg tcgactgtcc cagaaattta gtggcgtagg cctgaaacga tccggccacc 3245401 ggcatggcaa cagccaattc tcctaaacaa agcatgacga gatacattaa aaatccgccg 3245461 atgatatacg cggcaatggc gccgagcggt cccgcctggc taatggtaaa gccagagcct 3245521 agaaacagcc cagtgccaat cacccctccc aaagcaatca taaacaaatg cctgcttttc 3245581 atgctgcgct gcaattcatt tttatgattc tgcatcatcc ttcccccttt ggttcttttg 3245641 ccgtgatggt catccggtag ctttgcaaaa gatgaacggt ggtttgctgt atgaggagag 3245701 gcaatacatg aaatgtgtac ggtttataga ctcgttctgt ccatttatgg ccgtcttttc 3245761 cgtacacgcc catattaatg gatggaatat tcagcttgcg tatgtctttg aacggaatgg 3245821 tcccaatcat attccaccca gggaagttcc tgataaaaga atcaatttcg ccatcggttt 3245881 cgtgcagtga taaaaaactg ccgtctgcca agtaggggaa aaactttttg aagacaaatg 3245941 tttcgcctgt cgattcagcg gttttgtcag ccgcttcttt aatcacatgc tgcaaaagct 3246001 gatctcttgc gctatcttct ttcaaatagt tatgcggcag gtaaggaggt gcgtaaaata 3246061 gaatgacttt tgcgccttga tcggggtcaa gcttttgaag ctcttcgatt gcctgaaagc 3246121 atctcatgcg aagttcaagg tgctcgttgg ctttgaatgt ctgctcgata cactgctcgg 3246181 gatctattcc ccggtttctc agcttttcta agtattgctc caggctatac acttgaatgc 3246241 cccatgataa atgtttcttt ggcaggttgg ctctttttac atattcttcg taataatctg 3246301 ataatttttg ttctgtctcc cggcatgctt cctcagtgac ttcaataagc aaatccatca 3246361 tttcttttgc tgttctttca taaataaaac aattgaaata caagctggtg ctgacagccg 3246421 tttgcacatt ataggattcc ttgttatcac gctgatacaa acaggatggg ggcagaacca 3246481 actccccttc aaccttttct gccagatgga tgttattgtg gagacggctt gtgatttcag 3246541 atgaaatgaa atttgggtca atccctgcca gtgtatcgcc aacatggact tcacgcccgt 3246601 aaatgtaaaa gcaaggcaac agttttcccg cggctccggt atagatatat cttgtctgat 3246661 caccatcgta aagcggggta ataaaatccg tattaatagc agccaaatag tgaagctgtt 3246721 tttctttttt tagccggttc agctctgaaa tgctggcgag aatgcccgaa tgctggctct 3246781 cctcatcggg attggccata aacaatacat ttcccggcaa cgtctcaagg ttctccgaaa 3246841 aatgcaggag attggctaaa tgcacggcga tgccgctttg catatcgaca gatcctcttc 3246901 cgaacatcca ctcgcctgat ttggcatccc gctgaacatc ctgatcgaac tcatagcggc 3246961 tgaaatactc ggccaatttc tcacaatcaa aagcgatatc ctttaaaggg ccgaaatctt 3247021 caattccaac tgtatccaga tgggcatggt aaatgactgt atttcggctt tctccatgtc 3247081 ctttaataaa cgcaaaaata tttttgcgtt tgtatgggtc attgggaatg gcctgttccc 3247141 acacatgact ggggttttcc tgaaaataag gatagctcgt gatcacttct ttgatgaaat 3247201 ctgcttttgt cccttctcca acggtgccgt tcacgctgct gaggctgacc agagatgctg 3247261 tcagcgcctc cactctttca gccggattca tgtgactgat ttttgtatac tgcataaatt 3247321 gtcctcctga tcaaaaagtt gaaatcgtgc gatccgctaa agaatcgcac gattttattt 3247381 ctctcaaatc aaaaagcttc ggacgttgtt ttggcttgca tatgaagaat taagtaatcg 3247441 ggaccgcctg cttttgagtc tgttcctgac atattaaaac cgccgaacgg ctgatagccg 3247501 acaattgctc cggtacatcc tctgttaaaa tataggtttc cgacatggaa atcctcgcgc 3247561 gcccgttcaa tgtgcgcacg gtttttcgtc agaagcgcac ctgttaatcc gtattccgtg 3247621 ttattggcaa tctccagcat atgatcgaaa tcacgcgctt tgcaaatcgc aacaaccggg 3247681 ccgaaaattt cttcctgcat caagcgggcg ttttcatcaa catctgcaaa gatcgtcggc 3247741 tgaataaagt agccttttga atcatcgcct tctccgccgg ccaatagctt gccttcagat 3247801 ttgccgattt caatgtattt catcactttg ttgtaggatg cttcatgaat cacgggaccc 3247861 atatacgtat caggatcttc tggattgccg acagtcagcg ttttggtcag cgccacagct 3247921 ttttccacca cttcatcata cacatcctga tgaatgaccg cgcgggagcc cgcagaacac 3247981 ttctgtcctg aatatccaaa tgctgaatac acgatagagg atgcagcaag gtcaagatca 3248041 gcgtccttgt cgacaagcac tgtgtctttt ccgcccattt ctgcaattac ccgtttgagc 3248101 catttttggc ccggctgcac tttggcagct cgctcataaa tccggcagcc gactgcacgg 3248161 gaacctgtaa atgagacaaa ccgtgtcttc ggatgctcaa ctaagaaatc accgatctcc 3248221 gcaccatctc ccggaatgta attcagaacg ccgtttggca gacccgcttc ctccatgacc 3248281 tcgacaaatt ttgctgccac taccggggct gcgtcagccg gttttaagag aatcgtattt 3248341 cctgtcacaa tcgctgccac cgctgttccc gccataatcg cgagcgggaa gttaaatgga 3248401 gaaatgacga tgccgacgcc aagcgcttcg taatgatatt gattgacctc gccagcacgg 3248461 ctcttcaccg gagccccttc cttgagcttt aacatttggc gcgcgtagaa ctctaaaaag 3248521 tctatcgctt cagccgtgtc cgcatctgct tccttccacg gttttcctgc ttccttcaca 3248581 agatagcttg aaaattcatg ctttcttctg cgcaaaatag ccgctgcctt aaagagaata 3248641 tttgcgcggt gctccggtct ttgttttttc caggaatcaa atgcctgcaa tgcggcttgc 3248701 atcgcttttt cagcaagctc ttgatccgct gtagacgcgt acccaatgat ctcttcttta 3248761 tttgccgggt taatagaaat gattttgcgg tccgtttcaa ttttttctcc atttatgaca 3248821 agcggataat gcttgccgag ctgagtgttt acaaaggcca atgactcccc aaatgcagtt 3248881 ttattctttg cttccgtaaa atcggtaaat ggttcgtgcg cgtatgtgac tgtcatatgt 3248941 agtccccctc gtgttatgaa atatatcttc gcatatgaat aaaaatgcaa gaatcatgcc 3249001 attttcttgt cttttgctga aaaaacttgt tgaatcgaac agaaatttgt ctaacaggtg 3249061 atcacctttc tctttttccg atcttgaacg caaatttatt ttgcgttttt tgctctttac 3249121 gcaaaaaaca aatgcaaaat tattttgcgg aggcttctca aattagaccc atccgcggaa 3249181 acgcgatgct tctgccgatt ttctgatgcc cgtcatgtaa gccgccaaac gcatatccac 3249241 tttatgtgtt gccgctgttt gataaattgt ttcgaacgag ctgaccatga cgcttctcag 3249301 tttttctgca acctcttctt ccgaccaata atatccttgg ttgttttgca cccattcaaa 3249361 ataagaaacc gtgacgccgc cggcactcgc taggatatcc ggcacaagca gcacgcctct 3249421 ttcattcagg atcttagtgg catcaatggt tgtcgggccg ttcgccgctt caacgacgat 3249481 tgacgcctga atgttatgtg cgtttttggc tgtgatttga ttggagatcg cggcaggcac 3249541 taaaatatcg caatcctttt caagcagctc ctcatttgtg atgacgtcag taaataaatt 3249601 ggtgaccata ccaaagctgt cccgtttatc gagcaaataa gggatatcaa ggccgtctgg 3249661 gttgtagagc ccgccattgg catcagaaat cccgatcacc ttcgcgcccg catcgtgcat 3249721 gaatttggcc aggaagctac ccgcgtttcc aaagccctgt atgatgatgc gcgcgttttg 3249781 cagcttgatc ccttttttct tcaccgcctc ttcaatacaa atcgtgacgc cctgtgccgt 3249841 cgctgtttcc cgtccttgcg atcctcccaa aacaagcggt ttacctgtaa taaagcccgg 3249901 agaatcgaat tcccgcagcc ggctgtactc atccatcatc cacgccataa tctgcgaatt 3249961 ggtgtacaca tcgggagctg gaatatcctt tgtcggaccg acgatctggc tgatggcacg 3250021 gacatacccc ctgctcagcc tttccagttc tccaaatgac attgtccgcg gatcacaaat 3250081 aataccgccc ttcccgccgc cgtaaggaag attggcaatc ccgcatttga gcgtcatcca 3250141 aatggataat gcctttactt cctcttcatt aacttctgga tggaagcgaa cgcccccctt 3250201 tgtcggaccg acagcatcat tgtgctgtga ccggtagcct gtgaacactt tgacgctccc 3250261 attgtccatt ttgaccggaa tgcggacagt gagcattctc tgcggctctt tcatgagttc 3250321 atacatatct cccggataac ccagcttccg aagggcttcc ttaatgattg tttgggtaga 3250381 cagaaataag ttaagagctt ctttttcttc atctttcgag acttgctttg ctgacatctt 3250441 tttcacctca ttgttttttt ggccggctgt aatgtaagcg ctttaaaaaa tcagcccgcc 3250501 aattcctttc ttcattggat tcacccttat catcatgcaa gatccgtacc agcttttgaa 3250561 tccacaaaaa aagagactga aaacatctca gtctctgact acaaatctat cgattaacgg 3250621 ggatcaatca ccagctgcgt ttcagcataa aaactgccga ttcccaaacc gtttactaca 3250681 tcgcctttaa tcgtgtaagt gcctgcgcga ggaagagttt tacgcaccat gacaaggtca 3250741 aattcggatg cgcctaacaa atcaagcgta agcgggagtc tgactgtttt tccatcgttt 3250801 aaaatctgtg tttctttcag tgttcttcca ttcactgaat ctcttgtcgt agcatgaaac 3250861 ccgtcaggaa attgaaattc taccgctcca agagaaagca ccgcatttgg tttatatgtc 3250921 acttcaatat cagaaatggt ccactctttc gtgctgttaa ctgtttttgc ctcgattgat 3250981 gcagactgtg catgagcttg gcccgaagga agtaagattg atagtaaaac agctgaactg 3251041 atgaataatg aagatacgaa tgaagttctt tttagcatga catttccccc taattgattg 3251101 ttgaaatttg gccagagcgt cctctgcaga aaaagcgctt tttcataatt cgcgaattac 3251161 cagttctttt tcttaaaaat taatctatca tcattttcca tggaagtaaa tgttttttaa 3251221 ggaatattaa cacttggaat tcaatgagaa ttccttcctg tttatacaag gttcaaatgg 3251281 acgatttccc tctctttttc tagtaacatc tgcctgacat tttatatctt ttatcctatt 3251341 ttaaaaaagg gcaaaaaaag tcgaagatgc ctctgctctt cgattgatca cgttcctatt 3251401 tttatctgaa ttcagtgttc cagttaaaac cgatcgtctc atcatcccac ggaattcttt 3251461 tttcatcagg ctgatccggg ttatacgaca tggtggtaaa atagataatt gtcagcggcg 3251521 tctctcccag cactctatat ccgtgagcca ccccttttgg gattaataac agcatcgggt 3251581 tgtcttcgcc catataatag acgtccgttt ctccttttgt ctttgaatcc tctcgaagat 3251641 cgtataggac aacctgagcg tggccggttg ggaagaacca gagatcatcc tgcttctcat 3251701 gataatgaaa tgccttaatc acacccggat agcttttcga ccaagaggcc tgcccaaaat 3251761 gctcaaggag attctcatcg tcccggacca gctcagcaaa aaagcctctg tcatcgctat 3251821 gcttcatcaa ttttttcacc ttgactccat caatcacacg cactgctcct ttcctgcaaa 3251881 tactctcgta acgcttcccg ccagtggcgg gggcggatgc cggcttcttc aatagcccga 3251941 tggctcagca cagagtatgc cggacggggc gttttgttcc cgtattcctc tgtcgttaca 3252001 gacaaaatgg ctgtttccag cccgctttct tccataattg ccgtcgcaaa ctcataccag 3252061 ctgcatatgc ctgaattgct gacatgatag atgcccggcg gatggctgaa cagcttgatg 3252121 accgcttctg ctaaatcctt cgtataagtc ggcgaaccaa tttgatcgct gacaacccga 3252181 agctcttgtt tcgtttcagc aagtttcagc atggtttcaa cgaaattact gccgccatgt 3252241 ccgtacaccc acgatgtcct gatgatcgtg ctgtcttttg tcgttaatcg tatcagttct 3252301 tctccgagcc ttttgctttt gccataaatg gttttcggat cgaggggatc gtcttcccta 3252361 tatggctggg ttcctttccc attgaataca tagtccgtgc tgatatgaac atattgagct 3252421 ccgatgcggg ttgactcaag cgctgtataa taagcgccga ttccgttaat caagtacgct 3252481 ttatcaagct ctttctcgca ttgatcaacc gacgtaaacg cggcgctatt gaccacgata 3252541 tccggctgat aatggccaaa cgaatgccgt actgagcgct ggtcagcaat gttcatcatc 3252601 ttctttgtta acgcaatgac ctcatatccg gcttgcttca gctggcggca tagttccaag 3252661 ccaagctgtc ctcccgcccc agtcaccaat acctttgtca atcagatcac cttctcatcg 3252721 gtcattgtct gtataccact gaatcgtacg cgcaatgcct tcttcaaacg tcacttcctg 3252781 ccgccagccc agttcgtttt tcagctttga tgcattgatc gcatagcgcc ggtcatgccc 3252841 ttttcggtct tccacgtggg cgaacaattc ctcacagccc agatgcttca aaatgacact 3252901 cgccagctct ttattcgtgc gttcatttcc gccgccgatg ttatacacct cgccgtcggt 3252961 ccctttttct aaaatcagct tgatcgcgcg gcaatgatcc tccgcaaaca gccagtctcg 3253021 gatctggagt ccatcgccat acagcggaac aggcaggccc tgcttcgcat gacggataat 3253081 cgtcggaatc attttttcgc tgtgctgata aggtccgtaa ttgttgctgc atcgtgtaat 3253141 gatggccgga agcttgtggg ttttcacata agacaacacg agcaaatcag agcttgcttt 3253201 gctggctgag tatgggttat taggagaaag cggcgtcgtt tctgtaaacg cgggatcatc 3253261 cgcttttaaa tccccgtata cctcatctgt tgaaatatga atcagcttct tggcttttcc 3253321 tttcaagacc gcttccgcca atcggtatgt ccccatgaca tttgtggtga taaacggctc 3253381 cgcttgggaa atgcttctgt ccacatgcga ttctgctgcg aagtgaatga cgccatcgta 3253441 ggtctcgtca aaagcgcggt cgatatcctc ctgaacgctg atgtcccctt ttacaaagcg 3253501 aaaacggctg ttttgcttta atttttccat ttcctccggg tggctggcgt acgtcagttt 3253561 atctaaaacg gtaatgcgcg catccgtttc cctcagcatg agctttgtaa acgtgagccc 3253621 gatgaagccg gccccgcctg taattaaata tgattttgcc atcacttttc gtcctgtcct 3253681 ttccgtaaag cctggtgtac aagctgggaa gcgagataaa gcgattcgtg agttccggca 3253741 tctacccacc agcctgataa cacatcatac gtaagctggc tgttttcgat gtatagatta 3253801 ttcacatcgg tgatttccag ctcgccgcgc tttgatggtg atatttgttc aatatatgaa 3253861 aacacctctg catcatacat ataaatgccg gtaacacaaa ggttggtcgg tggctgttcg 3253921 ggcttttcga tgatggaacg aatccgcttg tttttctcat caatctcagc aatcccgaaa 3253981 cgttccgggt catcaacttc tttcagaagc acttttgctc ctttcccctg ctgttcaaag 3254041 cgttctgtat aaggctttaa tgaatcttca aatatattat cacctaataa taaaatgaaa 3254101 gactcttttt tcgtaaagcg ctttgcataa gacagcccat ccgaaatgcc cgatgctgcc 3254161 ggctgtactt gataagtgat agtaacgcca agctcttccc cgttcccaag cagtttgtaa 3254221 aattgcggca tatgctcctt ttggctgatg agtaaaatgt cttttattcc ggcttcctgc 3254281 agcttcataa tcgaccagta tatcatcgga tacgggccta caggaagcaa atgcttgttg 3254341 acggctttcg ttaagggcat aaggcgtgag ccgtttcctc cggctaaaat aacacctttc 3254401 acattaacac ttccttacat gcatttttat atctcttgtt catataaatc ttgaagaata 3254461 gctgttaccc gtataatgcc tttgccatcc acgagcggcc ttcctccctt gtgcaaagaa 3254521 aggcgaagag gatagctgct cataatgcgt gacatctgat agatgagtgt ttcatccggt 3254581 acaagctcac ccaatccaag atcaagagcg gcgccttggt cagcaaatgt tttggctgta 3254641 gccgtttgat gctcaacctg agaaagaaca aggcacggca cgccgatgca aatggcttca 3254701 tatagagaga tgccgccagc gacaatggct gcgtccgctt gtttcatcaa acctgccata 3254761 tcatttgtct gttcgatcat cttgtactgc ggcttctttt cgatccgcct tcggactgcc 3254821 tcttgatgcg gtgaagcgct ccccatcaca aacatcatgt ttttgtcttt tatgtcgggg 3254881 acttgatcag cggcagccag cactttaaaa ataagctgct tcggatcact tcctcctaat 3254941 gcaacaagga tattgcggca gtctttctta agtgtgtaat cctctcttgc ggcctgaaag 3255001 gcggggtgaa gaataagata gtccggacct tcatagatgc gtgtgtttcc ctgaacgtac 3255061 accctgcttc tgatgtcacc gtaaattccg ttaatgactg cgtcactata ttgaatcgat 3255121 ttaccgtttt tctcttcaaa aagaacaatt ttcgcatctg tctccgtctt tattttcttt 3255181 aacagctctg caggcgcgcc tagaatatca aacaaaagca aatcaagctt cttgcttttt 3255241 atttcccgga gaataaattc gtgctgctgc agctccggct ttacgatgac ctgccaatgc 3255301 tcttcatgaa gaaacgcttc agaatcctga ttcgtataaa acgtaatcaa gcatcgctgt 3255361 ttgagcccct ccgcaagcct cttcatccgg acaacatggc ccattccctt ttcatagccg 3255421 ccgtctgcga agatcccaac atgcatggct agtcagcctc tcgttcggtt gccgcatcgg 3255481 ggttccggtt cagaagggtg ataagctctg aggcggatac atcggggcgc tcgcctgctt 3255541 tttgatagag ggcctttatc gattcatagt cttcctttgt atcaatggtc agccgatatt 3255601 gaggggcgcg aaatcgttcc ggcgcctcta aaaactgaac acgataaaga gctggatgat 3255661 tccttatata taacgtgaca tgctcctgat attgatcctc caaagcctga atacggctga 3255721 tgtcaattaa caggttggcg ttgaccactt cgccgcaaat ccctaatggg gcattcagga 3255781 tatacgtata atccgagcct tgatcaaaat gcgcctgaat cattacatcg agcagctcag 3255841 gatcgacaaa cggattatca cctgttaacc ggatgatgac tgacggttta acagcttcta 3255901 tgaccttcac aaacctatcg aggacacgtt cttcgctccc gcggaaaaca cgaaagcctt 3255961 gtttgataca gtgcgcctct aatatgtcgt cagtttcttt gtcagacgtg gcgatgacaa 3256021 gattatcccg atccttttgg taaaacgcgc tttgccggac acggtgaacg agaatatcaa 3256081 gtaaacgatt cgatccgagc ggccgaagca cttttcccgg aagccttgtt gaacccattc 3256141 ttgcttgaat gataaagaga atatcattca tgaaacgggc tgtccttcag taaaatgtca 3256201 tcccagacaa tgcctgtgtc ggctggaatg tctcttacag cccgaacacc gctggtcagc 3256261 agttcaaaaa atctcgggtg cagcccctgc ggcttttgtc cgggccgaag cactgcgata 3256321 ttgtcttcac taaaggcttc acctttttga atcggagctg ttgtaaaaat gcctctgtat 3256381 gcaaagtttc tgatttctcc ttcgatggcg gtcgttgttt tgtatgaact gccaagcagt 3256441 ttttcagaga ccggctttgt gatcccctgt ttcagctcag cttccgtttt cctgatgcca 3256501 tcgaccattt ctttcaattc atccggattt aatgcaaacg agtggtcagc acccggcaga 3256561 tttttatcga tcgtaaaatg cttttctatc agttttgctc cgagccgaac cgcggcacac 3256621 ggcgcttctg tcggatgctc gctatgatcg gagaagccga ttaccgcctc aggaaaagcg 3256681 gcggcaagca tcggaatgac gctgaggttg ctgtactccg gcggtgctgg gtatttcgcc 3256741 acacaatgca ttatggcaat ttgattgttt ccctctgccc tgatggtgcg ccaagcttcg 3256801 tgaacatcag agatttcagc tccggctgtc gagaaaatca tcggcctgtt cagccgggcg 3256861 acatatttaa gcagcgggag atggttaatt tcataggatg cgattttaaa agcgctcggc 3256921 gaggtagact gaagcagatc agctgacccc tcgtcacata ccgtacttaa aaagatcacc 3256981 tgcttttcgc ggcagtaatc caatagcggt aaaatccact cagcaggcat ttccatagat 3257041 tgaaccaaag aaaaaataga gacgtccttg cccgctgccg tcttgtacaa accaggatct 3257101 ttctggtaca tcctatcagc ttggaacatt tgaaatttca cggcatccgc tcccgcttcc 3257161 gccgcggcgt ctatcagcgc aaaagcctga tcaagcttcc cgtcatgatt aatccccgcc 3257221 tcagcaataa taaaaacagg agcgtctttg cctacagttt tattcgcgat ctgaaacgct 3257281 gccattattt cgcctccttg cccggccaaa tatgataata gtaatacgat tgttcagcgg 3257341 tgaagcccat tcgttcataa aggcggatcg cccttacatt gtgaagctgc gtccccgctg 3257401 ttaccgttct atgcttctgg gtctccggtt gttctatgag attcgccaat aaatgaaacg 3257461 caatacgttt cccttcaaat cccggcttta cagccatcaa atcgagaatg cactcatcat 3257521 ctcttgataa gccctgaaga tagccgatga cctcgccatt gtgtttagcg acaatattga 3257581 ccgccgccct tccattcaga ttgtttcgtg tccactcctg aaatatttcg tttgctgcat 3257641 cgcggctgag atgaggatcc tgaaaatatc tgctttttgt aaacgagtct cgggccagct 3257701 cacatatcgc ttctgtgtct ccgggctcag gcgggcccag ttcaaaaaat ggcggtgttt 3257761 tgtcataaaa agacggaggc atcgccagct tcagcaaact cccgacaaag taagaggatg 3257821 gctgctgttg tatcacatgc gcggctccga tatcttcagc cggaacacgg acaaagataa 3257881 aatccgtttc atccatttgg cgtacagtat aaaaagcttc aaacagcctc tttagctgcc 3257941 cggtactatt tgccgcaaga agtttgacgt tcatgacttt cttctgaagc accttgcttt 3258001 cccacaaaga atcttcgtaa agcaatacgc cttggagcct gctgttttca aaaaggccga 3258061 gggaaaattg atacggaaca tccaatgtaa gctttctgct ttggagaaat tcctcaattg 3258121 cctctttgga gacattttct tttaccgtat acacttaatc agcccctttt acgatatccc 3258181 gcacagcttc aatgacatca tctacatcat cgtcagacat tgatggatag agcgggagag 3258241 aaagggttcg tttatagtaa ttcatggcat tcggaaagtc cgcttcctta tatccaaatt 3258301 gcttttgata atacggatga atgtgtactg gaataaaatg aacgctagtg ccgatattgt 3258361 attcatcctt taaagccgta atcatttcgc tgcgcgtaac cccggccttt ttttcatcaa 3258421 cttgcagaac atatagatgc caggcgtgcc tgccgtcatc atggacaaac ggcgtgatca 3258481 gcccaggaat ctgctgaaaa gcggtttgat agcggccggc aatctcttct ctccgtttct 3258541 gcatatcatc cagccgtttc agctgatgaa gtccgagggc cgcctgcaaa tcaaacatat 3258601 tcatcttata gccgggcgat tcgacttcat agtaccagct gccatttgaa gaataacggt 3258661 tccatgcggc tttactcatg ccgtgaaggc ttagcacccg tatcttatcg gcaagctcct 3258721 catcatcagt cgtcagcatg ccgccttccc ctgtcgcgag gtttttggtg gcgtaaaagc 3258781 tgaatgccgt tgcatccccg atagaaccga tcattctttg cttataagtc gtatataccg 3258841 catgtgccgc atcctccagc acgaataaac catgattttg ggcaacagcc aatattgcat 3258901 ccatatcgca ggactgcccg ccaaagtgga cgggcacaac tgctttcgtt cgcggtgtga 3258961 cggccgcctc aagctttacc gggtcaatat tgagcgtgtt ttcgtcaata tccgcaaaca 3259021 caggcgtcgc tcccgtatga ataatcgtat tggcggtcga gctgaacgta agcggagagg 3259081 taatgacctc gtccccgggc ccaatccctt ttgctttcaa agccaaaaat aaagctgcgg 3259141 tacatgaatt caccgccacg gcgtgcttcg ccccgacaaa cgcggcaaac tctttttcaa 3259201 actgctgaac cttcgggcct ttagagagcc atcccgattc aagcgtttct gtaacctcct 3259261 gaatttcttc cttaccgatt aacggcaatg agtaagggag aaaatgattt ctcttttgca 3259321 ccatttcttt gcgctcctat cattttattc agtatcttcc cgcctgtaat caacccctgt 3259381 tttggctttc agttccgcaa ataaagcatt tgttgattct gccaccggat aattagccgc 3259441 tatgaatgcc aggcgcgcct cttctgcttt ttgatgcacg tcgggacttc gaagaacctc 3259501 aaccaaggtg tgcgccagtt catccggctg gtcaaacata aaatcgccaa gagactcata 3259561 atacggatac gagcgatttc cggacgattt tcctatcagc acaggctttt gaaacagcat 3259621 ggcttcaaga ccgactgtcg aggtttgcgt cactgcggca tcaacatacg gcagcaaatc 3259681 ataaagctcc agctcctttt tgatgactct gcatgcttga tgttttttcg ccgcctcgtg 3259741 atacagatca agcttgtttt ttccgatttc ccacgggtgg ggtttgataa tgatttgcag 3259801 ctgcttctga tcagaaagcc cctgcagcac accggaataa aagtcttctg aaaagggctg 3259861 agtggcaatg agcacaattt ttttagtcgg ctgaaaagca agttttcgat agaatatgga 3259921 catatccata ggcgttctgt taaaaatctg atcgaagcgg ggatgtcccg ttacgagaat 3259981 ctgctcgggt ttacagcctt ttcgtatgaa ccactctgct tcatacgcac caaaaacagc 3260041 ttgataggtt gtaaaaacag gaatgaaggc ttcatctccc atcaatgcgc catgctgaag 3260101 acaaatgctg acggcccctt ttctttgaca catgagagcg agcaccctgc tgtaaatgtc 3260161 ttctgccgtt ccgacaataa cagctgaaat cttttcctgt tcaaacagcg catcaactgt 3260221 atcaatggcc tctataaata aaggaatatc tttgaaaagc cggtcgcgaa acgcttgatc 3260281 accaaatgcc gggtgatcat cataaggggc gagaagcgaa caggctgttt cgagatactg 3260341 cttcgaatcg cctttttggc atgaatccgc aatctcccgc ttgctaatta caggcagatc 3260401 acaataatgc ggcaaactcc atctggccaa aacagccgtt ttttcaggat caaattgata 3260461 gtaattttcg tttgaaaaac gcaggtaatc aaagtgcaaa atgactttcc ctttaacagg 3260521 ttcgtcattt gttttaacga tgttttggat tctttcttca aaaaacggct gaatctgtcc 3260581 ctcatcgata tgctgatcca ccgatccgaa taattccggt tcttcttcca tcatcaccct 3260641 cagttcaggg ctgatgtatt gataaaaatt actgataagc ccaagcggaa tccctttgta 3260701 gcgaagtttg tcaaaaagct ccacgtactt ccggtacagc acccaataat tgcttaaata 3260761 ggccgacaag ctctcacccc attccaagct tttttaatga ttcacgcagc tctcggcaat 3260821 ttcgctgcgg aggaaggttc ctgacaaatt catttttttc taattcaaac agctgaaagt 3260881 gaatcgattg gtcggtaata taattcaggt ccagctcctc atccagtggg taaaacggat 3260941 aaaaatgatt gactctccaa aagaaccggg catctcctat acggtaaaac gccgggcttt 3261001 catcccaata ggagccaaac ttctccttta ccttctcaag caccgaatac ctgtgcatca 3261061 ccgagcaatg atcaattgcg cacggcgcgt tccatgtcac ttgagcggca ggcctgacag 3261121 tttcttttac aatgtcacga ttctcgttta aatgataggt tttggaggct gagtaaatca 3261181 cagccttttc aggatgggta tcgagctccc gcaccatttt caggaggcgg tccggcatat 3261241 agatgttgtc atccgtcgca taggtgatat attcaccctc cgccatctca atcgcctgat 3261301 tgatcagtgc cgcgtatctc gttttttctg ttctttcctt cactccagat atatcgcttt 3261361 gataaaaacg cactcggtta tcattcaaaa aaggacggat tacattcagc gtctcttcat 3261421 tggagttgtc atccataata aacaattcaa aatctgaaaa cgtttgtgag agtatgctag 3261481 aaatggactt tgccacataa tcgcttttgt tatagctcgt cataatgact gatactttag 3261541 gcaaatccta cacctccttc ttggaacttc acacctgaaa ctatcgttat cttatgttgc 3261601 ttatgctcaa gttgcgctag ggatacaaac caatatgcga aaagtttgtg tatgtttctg 3261661 aaaaacagcg gctgcccaga gcgaaatctg atcggtccgc tgttcttttt cagcataatc 3261721 caagcatcag cctcataagg tgaaagagat aaaaatcgca ccagcgacta agatcgtttt 3261781 ccatcggagg tgagtcatcg cggagcgttc acctatacat ccagaacatg ttttgaatgg 3261841 ttttcataaa aaggaggaac gatatgaaac cgaaaaaaaa tcaatatcag caaatgcagg 3261901 catttgataa tatgcagggg tatcagcctc agtttggcgc caacccgtac ccgcagcaag 3261961 gccaaggctc acaaatgcag acaatgggga tgcagccaat gatgccaatg cagcagggac 3262021 agcaaggaca acaaggacag cagggatttg gattcccggg ccagcagcag ggcggcggtt 3262081 ttcaaattcc atcggggcct acaccgtcag gaccgggcca aagcgttccc ggcatgctgc 3262141 ctgttgagga atcttacatc gagaatattt tgcgcctgaa tcggggaaaa acggccacca 3262201 tttatatgac atttgaaaac agcaaggaat ggggctcgaa gatttttcgc ggcgtcatcg 3262261 aagctgcggg ccgggatcac attattatca gcgacccgaa atcaggaaca cgctacctgc 3262321 tcctgacaat ctacctcgat tacattacat ttgatgaaga aattgcttat acgtatccat 3262381 attccatggc gtcctattcg ccaagataag aaaaaagcca atcactcata tgatgaggat 3262441 tggctttttt gtttatagat atttgacggc tgcgacaacg atcataatcc aagaaataat 3262501 aaacgccaca ccgccgagcg gggtgatcgc tccaagaatg gagatttgcg tcacacttag 3262561 aatatataag cttccggaaa acagcacaat tcccgcaaac atcagccagc cggctgtcgt 3262621 gacactgcct atgccggata atttatcagc cagaaacgcg acaacgaata acccaagggc 3262681 gtgatacata tgatactgca cgcctgtgtg ccaaacctga agatacttat caggtatttt 3262741 cccttctaat ccgtgagcgc cgaatgctcc gagtcccacg gcaagcaggg cgttaatggc 3262801 ccctaatatg ataaaaactt tcatctatct ctcccgcctt ttcgttaaac tcatatcatt 3262861 tatcttatcg cacctgcacc aaaattcaat gtttgttctc cgttgacacg agattgtcgg 3262921 attttctcct gcgccaaagc tggaactggt cagctgctat tgcagcaagc gtccctaata 3262981 cgagcccgtt gcttaataga gaaataaata ccggatgcaa tccctttaac gcagtttcag 3263041 gaacaaacat gataccgacc cctgtcagca gtgagatacc gatgatagac ctcacccttt 3263101 ttgattcttc tttctcatat gaatcaaatt cggcaaaggc cagaccgccc attgcggaga 3263161 acacaacaaa attcaccgca aatccaacgg gtgacggcag gctcgcaaac gtattcataa 3263221 aaaacgggat cacgctgatc acgataacca gaatactgcc gagcataaac ggttttttag 3263281 aaggcatctt ggtcgtttca ataaaacctg cggctcccga aatcggaaca ggcgcaatag 3263341 ctcccgtcaa accgctaagc agatggctga atgaagctgc aaaaccggca tggcgttcat 3263401 gatgctttcc atcaggctgt ttgctgaatt ttttcatggc gatgtccacg accttcatgc 3263461 tcgccagcat attcacgatc agcaagatgg taataaaaat agaagtgatg atcaggccgc 3263521 tgttaaataa cggggtccca aaaggaaaca gggaaggcag ctgaaacagc cggtccggca 3263581 tttcaatcgg ctttgcggct ccggcagccg caaacagcac ccacccgccg aacaaggcta 3263641 ataaaataga atattgctta aaaaacatga tgttcgaatt tgtcattata aaagcggcag 3263701 cgatcacaac aagcgccagg ccaaatacaa gaccgtccac cccgtcctgt cgataaccga 3263761 ttccgagaat tccttttata atgggctgac tcagctgcat gacaagaagc aataaataga 3263821 cgcccgttac aaccggagta aacaattttg caagtctgtc aatgaccttg aaaacactta 3263881 acaaaaagaa acatacagcg cttacaagaa gagctccctg caaaccccgc agtgtgtctc 3263941 catatgtcgc aaacacagtt cccgtcagcc ctgcgtaaat cgtatacact ccccaccaca 3264001 agccggctgg gctttcattg atcggcagtc tgtggccttt caaacactga atgacggcgg 3264061 caattcccag tacaaaaaaa gtgctttgaa tcaatcttgc agaatctgag tgatccagat 3264121 gaaacgactg ggcaaccgcc accggaacaa caatcgccgc agcaataata aacgctgtcc 3264181 attgcagcgc gccaagaacc aatttcacgt aagctcaacc tctctcttta aaaatcaaat 3264241 aaagactctc cgtttccatc ctcttcctgc ttctcttttt cttgctttcg atatttgttt 3264301 aatcccgcgc tccccatcat tttttccatc atcagctggt ctgtcgatgg cggcgcggcg 3264361 ggacttggcg taacgctcgg ctgtatgcgg ggcgcgctcg cgttctccgg ctgatcaagc 3264421 acgacatcac acagagaacg gacaaccgct acataacgct tcagctcctc atcccgttca 3264481 gccgtttttg ctttttttag ctcttcttcc atcttttgaa tcaaagcaga tatatgaatg 3264541 ttcatgaagc accctccaaa aaaataaatg ttgtcttcct gcattttatc aaattcctgc 3264601 tgaaaacgca gatatgagtt tgttattttt tctgacaaac cttgcgcgat tgacaagcag 3264661 aagagatttt tcacataata aatcaccata ccttacaaaa aggagaaacg gaatgaacag 3264721 catcccctct atcatcagca agcataaagc ctattttgcg gcgggacata cgagaccgct 3264781 tgaatcgaga ctgaacattt tgcgaaagct gaaacaagcc gtcagaactc atgaagccga 3264841 tctcatagcc gctctctacc aggatctcca taaatccgag caagaagcat actcaacaga 3264901 aatcggaatc gtcttggagg aaatcagctt tgtcatgaaa cggctgagaa aatggtccaa 3264961 gccgaaacga gtcaaaacgc cgttgactca tctaggctcc aaaagcatca tcatccctga 3265021 gccgtatgga accgttttgg tgattgcgcc ttggaactat cccttgcagc tggcgctttc 3265081 tccgttgatt ggcgccattg cggcggggaa cacggtcgtt ctcaagccat cagaatatac 3265141 gccggctgtt tctgctattc tttccaaact catcagcagc gtttttccaa ctgattatgt 3265201 cgctatggca gaaggcgggc ccgatgtcag cacagcatta ttacagcagc cctttgacta 3265261 cattttcttt accggcagtg tagctgtagg aaaaatcgtc atggaggccg ccgccaaaca 3265321 attaattccc gtaaccttgg agctcggcgg caaaagtccc tgcatcgtcc ataaagatgc 3265381 tgacattcag cttgccgcca aacgcatcgt cttcgggaaa tttacaaatg cgggacaaac 3265441 ctgcatcgca ccggattatt tatttgtcca cgaggacatc aaaacgaagc tcacagaaga 3265501 aatgaagcgt gcgatcagag aattttacgg ccctcagccg gaacggaatc cacagtacgg 3265561 caaaatcgtc agtgagcgcc actatcagcg gctgctcagc tttctgaatg atggcatccc 3265621 gctcacaggc ggacaatctg atcccaatca tcacaaaatt gcgccgacca ttctcgaaca 3265681 agtgagagat gactctccag tgatgcagga ggagattttc gggccgattc ttccgctctt 3265741 tacataccgc aatatcgggg aagtcattga gaaagtccaa tcgcgcccta agccgctcgc 3265801 cctgtatctc ttcaccacaa acaaagaaat tgagcgcgct gttttaggaa atctgtcgtt 3265861 tggcgggggc tgtgtcaatg atacgttaat gcatgttgcg acgccgtatt tgccattcgg 3265921 cggcgtcggg gaaagcggca tcggcagcta tcacgggttt gacagtttta acacattcac 3265981 gcacaaaaaa agcgtcgtca aacaaacgaa ccgtttcgac ttcgcatttc gttatccttc 3266041 ctccaaaaac gggctgcgaa tgattcgaaa aatactcaaa taaaaaagcg cagatcacct 3266101 gcgcttttta caaatcctta atacaccaat caatcggcgc ctctcccatt ttctccaaat 3266161 aggcattcgc ccgggaaaac ggtctgctcc cgaaaaatcc gtttctcgca gaaaacgggc 3266221 tgggatgcgt cgattcaatg ataaaatgct tggaggtgtc gatccgttct tttttcattt 3266281 gagcatgccg tccccacaaa ataaagataa ccggccgctc tctttcactc agcacgtcaa 3266341 taattcggtc cgtcagtcgc tcccagcctt ttcccttatg ggaattcgcc tgtccgcgcc 3266401 ttactgtcag cacagtattc agcaaaagaa cgccttgctt tgcccagctc acaagcgacc 3266461 cgtgattcgg gatgctgcac ccgatgtcct gctgcagctc aagaaagata ttttttaacg 3266521 aaggcggctg ctttacaccg ggcttgacag agaagcttaa accttgagcc tgtcccggcc 3266581 cgtgatacgg atcttgaccc aaaatgacga ccttgacatc atcatatgat gtataatgca 3266641 gcgcgttgaa aatatcccgg ctgtccggat aaatcgtttg ctccgcgtat tccctcttca 3266701 gcatctctct gagctcttga taatacggtt tctcaaactc ttcctttagc tgattccacc 3266761 agctgtcttg taaaagctgt ttcaagattc aggcctcctt acgaacgatg aagtctggaa 3266821 tagacaggct cgccatccca aaccatttca ctttttgctt cccgcctctt catctcaggc 3266881 tcttcaagca ggacggcaaa gtttttcgtc ggcagctccc cgagtccgtg cttttcactt 3266941 aaacgatcca aatattgctt ccgcttggcg ccaaggtcag cagactgatt gtctcccgcg 3267001 tcactgaagg cataaatcac gctggcgcaa gggacacgct tcacccggta atccttggcc 3267061 gcgcgcaaat aaaaatccca gtcccagtaa ttgtgcacat cagcatcgaa atacccgatt 3267121 tcatcatgca gaaaacgtct gtacatgctg cccgacggca cgtatgtaga aaacactctc 3267181 atatcctcat agtcagcggt ataagcaaac aatttccgtg acactggata ccttgttccg 3267241 tttttctctt caaacgaaac tatttccgca tcagaatgaa cgaagtctgc cgtttctatt 3267301 tcctttgcca ttttctcgat atgccctggc gtaaagaaat catcgtcatc acacagcata 3267361 atgcaatccc cagacgcctc ttttacaccg gcatttctcg cagccacatg ccccgagttc 3267421 ttttctaaat tgatgacagc aatcggcagc tccggataaa gtgctttgac cggcacgacc 3267481 gattccccgg catcattcac aataataatt tcatacggca tcaaggtctg gcgggaaatc 3267541 gactccaaaa gctcacacaa agccggaatc cgattatagg tcacaattac gatagaaatc 3267601 ttcatgatgc tctccttctc attttcatag tcatgtacta ttaaaacata tattggacgg 3267661 gagatcagtg ggaatatcct actgaaacgg catactacaa tgatagaaac agcaaagtgg 3267721 ctccgatcag aagcaccatg atcagcatca gatctccaaa gacatgaaag atatctttca 3267781 tgcggacgcc attcggaagg ataagacgcc acagcttaga ttgatagacc ggcagcagca 3267841 ccagtgcata agaaagacac aaaaatgtaa aagccggcgg cacaaaagca cagcctgcat 3267901 cgtcccaatt catcatgatg tctttcatac tagatccatc caataaaaac aaagatatca 3267961 tgagggctag caacacaaag gaccccaatt gaacctcaaa caggcgcatt ttctggttat 3268021 atgcaaatcg gaccgcccaa aaccagacat aagcatatga acatagcagc gtaagaatgg 3268081 cacctgctgt aaagacgaca tcaggcagcc gatcaagcag aaaaacaaaa ggcaagctgg 3268141 ctgccatagc caagagcatg cagccaccag taaacaaaaa tactgcccca tgagctacaa 3268201 aaccatataa acaagagcta atcctcacga catacacctc ctttacatag aaattctatg 3268261 tatataccta aaaaatcaga caagctgacg cctgccaata taacagccca ttcggccaaa 3268321 taacggaaat aacagcgttg caaaagcaca agttccaaca aaccaaggtg tcaacaagga 3268381 ttgaaacagc gcagcaggaa ttacattgaa tagaaaaaca agcataaaaa tgacgtttgg 3268441 caccattgag atcagaatcg tatgtagaac aagcttttct ccgcgttttc caaactcctt 3268501 cacgccttga tacccaatca gcacccagta gatcatatat gcagctaaga tcagccaaac 3268561 agaaacagaa atgcctttcc atactgcttg aacaaacggt gattcaagcc atacatgcat 3268621 tattgtaatc gcaatgccga cagcgaatag ggcactgtta cagaaaagat ggaacatcaa 3268681 aaacgcacga aacgttactg gctgtatttt cttaaacgaa gaaacaatgt cagttggtgt 3268741 tccaaacgcc tgcaataaag tctgcatagc ttcctcctca ctctttcctt cctgaaaaga 3268801 gcgaaacaga tgatgttcaa tatggctctc aatctcttct atcatcgcct caccctcagg 3268861 aagcccttta agcccgcttt tgatttcgga tacatatgtt tctttatcca ttttgtccgc 3268921 tccacttcag tattcggtcc atcatggctg aaaatacgct ccattccttc gtgcgttccg 3268981 ccagcacttc tttgccctcg tctgtaatcc ggtaatattt gcggtccggt cctttctcct 3269041 gcttctccca gtaggaagaa atataccctt ggcgttcaag cttgtgaaga gaaggataca 3269101 aggtcccttc tttcatctgc agttcatttc cgctgcggct tcccatttct tttacaagct 3269161 catagccgta catcggccgc tcgttcagaa gcgtcaatac caatataacc gtgcttccct 3269221 taaccagctc acgatttaac atctcaaaac ccctacctag ttttcttatg tagcatttta 3269281 cgaaagcccg ttgagattgt caaatgattc ctatagatct tctatattgt gatacagaga 3269341 aaatctaact ataatgaaag acaaaacatg atggaggttc aagacatgtc tatgcataaa 3269401 gcactcacca ttgccggctc agattccagc ggcggtgctg ggattcaagc tgatttaaaa 3269461 acatttcaag aaaaaaacgt atacgggatg accgccttaa cggtgatcgt tgcgatggac 3269521 ccaaacaaca gctggaacca tcaggtattc ccgatcgata ctgatacaat ccgcgcccag 3269581 cttgcaacaa ttacggacgg catcggcgtg gacgccatga aaacaggaat gctgccaacc 3269641 gttgacatta tcgagcttgc ggcaaaaacg atcaaagaaa aacaattaaa aaatgtggta 3269701 attgacccgg ttatggtttg caaaggtgct aatgaagtcc tttatccgga gcacgcccaa 3269761 gccctgcgtg agcaattggc tccgctagcc actgtcatta cgccaaactt gtttgaagcc 3269821 agccagctca gcggcatgga tgaactaaaa acagttgacg atatgatcga agccgcgaaa 3269881 aaaattcacg cactcggcgc tcaatatgtc gtcattacag gcggaggcaa actcaaacac 3269941 gagaaagccg ttgatgttct ctatgacgga gaaacagcgg aagtccttga aagcgaaatg 3270001 atcgatacgc cttatacaca tggcgcaggc tgtacattct cagcagccgt gacagcggag 3270061 cttgccaaag gtgcggaagt caaagaagcc atttacgcag cgaaagaatt catcacagcg 3270121 gccattaaag aatccttccc gctaaaccag tatgttggtc ctacgaagca ttctgcactg 3270181 cgcctgaatc aacaatcata aaaaaagggg ctgccttaca gagaggcagc cctttttaaa 3270241 tcaccgaaga cttttcacag aaaaaactgc cgatcccatc ggcagcctgt ttatttgatt 3270301 tttaaattgt ttgcagattt cctcaaaaat gtttctatcg actgaacaaa aagtgcatat 3270361 tccttcattt gttcatatgc ccgcgtgaga atttccgccg tttcactgtg cggcgttgtt 3270421 ccgccaagca tttttttcag ctgaagcagc acatccttat attcttctcg cttatcttca 3270481 acttggttag cagccttttc caaacattcc ggtgttatct tctgttcatg tatattcaag 3270541 aaaacaactc cttttacaga aaaaaatagt aggttatcgt tgaagaatag cacagatggc 3270601 tcagatttca cataagaaaa tagaaggatt ttctacataa gtgtccaaat tccgacattc 3270661 atttcagatt tcccggtcgc actggctgtt acttcatgat ttcccgggaa aggaaaatat 3270721 cttgcactca agacctcttc tccgttattg ataaagattt ccacagatga cgcgtcgaga 3270781 aacatgtgta cggtatgcaa atccttgatg cggcaatgtc tcgcttctgt tctttttccg 3270841 tcaaagctct ttcgttccag cgtaacaatc ccctcgtctt tatggaagga aaacgtagcc 3270901 gttccgcgga tactgattga aaagccagac tccgtatgaa tgtcttccag tagaatctca 3270961 gttctttcag gtttttccac tggaagcgca ccagatgatc catgcatgtt gatgtgtatt 3271021 tttttctcat ttctgcgcat ggcttttagc tcaggcagcg gctgctgaat cagcttctgt 3271081 cctgaaagcg tcagctgtct cggcagcgtc atgcagtgaa tccagtggca gtcaatggtc 3271141 ggatgggacc cttcatcctg atcaggcacc gccatccatg caaataaaat ccgccttccc 3271201 tgatcgtctt caagtgtttg cggcgcgtaa aaatcaaaac cttgatcaag ctccgtaaat 3271261 tcaccatgct tcagttcagg cttgttataa tcgaggcggc cgacaaaata acctgattga 3271321 tatacgttct gataacggaa accgtcagcc tcaagccctt gaggcgaaac aatcagcaca 3271381 tccgatcctt gaagggaaaa caaatcaggg cattcccaca tgtatccaaa atcgtccagc 3271441 ccgttgaagc ccgcgccggt tatcgggcca agaaatctcc actctgtcag gttatcagaa 3271501 gcaaacaaca cagcctgccc tttcaaattc tctgtttgcg caccaatcac catataccat 3271561 gtgccttcat gctcccatac cttcggatcg cgaaaatgcg ccgtatatcc ttccggaagg 3271621 cgggcgacga cacccttttt ctcaaaggac agcccgtcgt cagaaacagc aaggcattga 3271681 tacgtttccc gatttccatc ctgatccctg acatttcctg tgtaaaaaag atagagccga 3271741 tcgtctttcg tgacagcgct gcccgagtag cagccgtttt tatcaaacca atcactcgga 3271801 gccagcgcaa tctcttcccg cttccaattc acaacatcct gtgtcgtata atgcccccaa 3271861 aattttgcgc cgtgccccgt ctgaaacggc tgccactgaa agaatacatg atagctgccc 3271921 ttccaataaa tcacgccatt cgggtcattc agcagcccaa ccggcggcat gatatgaaaa 3271981 tgctggcggt gcggatcgct gttagcgatg ggctcttttt tctccacttc ttcataagcc 3272041 cggcgacgaa gctcctggtc atgtgctgtc attttttcct ctcctcatcc tcattaatct 3272101 tcatgacaaa tgctgcaatg aacgctgaca ctgccgcaat cgccatgcca atcagatagt 3272161 gaatcaagtt gctgaagcca aacggagccg caatggcgat catcggaatt cccgttaacc 3272221 cgtaagcgtt tgcagctaca tgtgtaaaga cgacatatgc cccacccaat gcgcctccga 3272281 tcatcgcggc gataaacggt tttcggtagc gcagattgac tccgaatatg acgggctcag 3272341 taatgccgag aaaagcggaa aatgctgccg gaagcgcgat ttcttttgtc tttgcctttt 3272401 tcgccataaa gaagacggca agacctgccc cgccctgtgc gacattcgcc attgaccaga 3272461 tcggcagcaa gtagtttttg cctatatctg caattagccc tgcctcaatc gcatggaagc 3272521 tgtgatgaac gcctgtcagc acgatgagtg aatacgtgcc cccgaaaatc agacctgcga 3272581 caaaaccggc atggtcatat acataagtta aagcaaccgt aatgccggag ccaagcgctc 3272641 tgcctagagg gccaatcgcg ataaaagcaa caaacccggt gacaatcaca gtaacaaatg 3272701 gtgtaacaag caaatccacc gcatgtggaa ccacttttct cgtccatttc tctaccttgc 3272761 tcatcacata caccgcaagc aggacaggga taacagttcc ctggtagccg agaagagcga 3272821 tatcaaatcc gaaaagatgc atgtaatcag gtgtcgcttc cgccaatccc catggattta 3272881 aaagattcgg atgaatcatg attcccccga tgaccgctcc caagtatgga ttgctgccaa 3272941 actcttttga agcgctgacc ccgattagaa tcggcaagaa aatgaatgct gcacttgaaa 3273001 acatatcaag cagctgcaaa agcgcagaat ccttgctcat ccaatgaaac gcattgatca 3273061 tacccagcaa tcccattaat aggccgctgg ctacaatagc tgggatgatt ggaacaaaaa 3273121 tattagaaag cgttttcgca aatctcgcag cgggattcag cttttctttt gccgcatcct 3273181 gatgattgac gtgttcttca cgctcgatat cagcttcttt agaaaaggca tcgaatactt 3273241 tattcacaag gcctgttccg aaaatgatct ggtactggcc agagctgctg aaagcccctt 3273301 taacgccatc aagctcttct acttgtgctt gatctatctt tgattcatct ttcatcacta 3273361 aacgcagtct tgttgcacaa tgagccgcgc tgataatatt ttctttccct ccgagaagct 3273421 caatgaggcg ttttgcagtc tctttgtaat ccatctattt ctcccccttt tatttaaaca 3273481 aaaaagacct aaaattcgcc aacgaataaa ggacacagcg atcctttttc atttacgcaa 3273541 attttaggtc ttgcctgctt taccagtcac aatcccgctt attcagatta agaatacgct 3273601 ttcatcataa atcatgatag cgttttcgtc aactattttt ttagttaaat agtttgatat 3273661 aacatgtaga caaaaattcg taaaaattaa ttgtgaaata cttcacaata tcgtgctata 3273721 ctatgctcaa tcatgaaaga aagcaggaaa agacaatgga aactcaagca ttacaaaagg 3273781 ttgaacagta tgctttgaaa aaacaaaaca tattcgcttc aagcaaaatc cgttatgtgc 3273841 ttcggtccat tttggccagt atatttattg gttttggcat tacagccgca agcaaaacag 3273901 gcagctattt ctttatggct gattctccgt ttgcctttcc ggcagccgct gtcactttcg 3273961 gggccgctat tctgatgatt gcttacggag gcggagattt atttaccggc aacacctttt 3274021 atttcaccta taccgcgctc cggaaaaaaa tcagctggcg cgacacccta tacttgtgga 3274081 tgtcaagcta tgccggcaat ttaatcggcg ccattctgtt tgccatcctg atcagcgcga 3274141 cgggactttt tgaggagcct tctgttcatt cctttttgat tcatttggca gagcacaaaa 3274201 tggagccgcc ggcttccgaa ttgtttttca gaggaatgct gtgcaattgg cttgtgtgcc 3274261 tcgccttttt cattccaatg tctctcaaag gggaaggagc aaagcttttt accatgatgc 3274321 ttttcgtttt ctgcttcttt atttccggct ttgaacacag cattgccaat atgtgcacat 3274381 tcgccatctc gcttttgatc gagcaccctg atacagtgac actgatggga gcagtcagaa 3274441 acttaatccc cgttacgctc ggcaatctga ccgcgggaat agttatgatg ggctggatgt 3274501 actacacact gaatcctgat caataaaaaa acttccagag atcactccct gcaagtcaaa 3274561 gcggttattc cgagagatct tgaagacgct ggacatgcag cgtgatatag ccggcctcgg 3274621 attccggcaa atgtaattga tattcatttt tcaaaaactc cgccagctcc agcgcacatt 3274681 gataggcgaa tgaatacttt ttttggatga aataaagcat ctcctcgtcc atacgatgga 3274741 gcgcttcatt tgattccaac cggctgaccg cgtatcgcaa atgcgtgaca aggcgttgat 3274801 aggaaatgct gttttcatcc acctttcgat taaagtattg ttttattttc tctatcattt 3274861 ctttgatcat ggtcgtatgc ttcagcgctg aatacatgct ctccgcatcc atcttcgccg 3274921 tatggatgtg aagggcaata taacccgctt catcttcagg cagagacacg cccaatgtct 3274981 cttttacatg tccgatcgcc cacaggccga tctcatattc ttttttatag agcgccttta 3275041 tctcatgcag caatttattc tgcacaagca gcccattttg aatcctttcg atcgcaaagg 3275101 acaaatggtc ggaaagcgcg atatgaatgt gatcgctcag cggcgccgcg agctctcctt 3275161 ccgcatagct gatgatatcc tcagctattt ctatatgctc ctccggcagt gtttgcagga 3275221 tttgtttgaa cttttcattc tcgtcgcgca cgacaaagat cttttccact ttattcatag 3275281 ggatgagatc atttttcttt ttttgaaaag cgattcccgg tcccatcacg attttttcct 3275341 gatcatcctc ttttattaaa gccgcattgt tgtttaatac tttatagatt ttcaagaggt 3275401 tatctctccc gccaatttgc ttttgactgg gattttacct ccttttgacc gccatgtaaa 3275461 gatgcgggcc cgctctctcc tgctttggcg attccttgaa ggcttgcaaa catcttcttt 3275521 tataaagcgc ggcggctttc gctttctgct tttcttcctc attcacagcc atccgccatt 3275581 cataaaacga aacgagtcct gcggcctgca cagccgcctt tctttggtat gtacgctgag 3275641 ccgaatagac cgcggcagcc gcagtttttc tgtccggcgt cacccagttc atcaaaaaga 3275701 ccatccacac ccgtaaagat acaagcaaac gtttcataga aaaacatccc tccgcttctt 3275761 tttggcaggc agccttttta gcagcccgtt ttctcagccg cagcccgcaa gaaaagacgg 3275821 ccgatttctt ttctcgcaaa ctagcggctc tagcaaaact catgactcta tgatagaccg 3275881 tggaaagaga attctttgtc acaatatgag tgaaaaaacc aactagtttt tagaagtttt 3275941 gttgaaagct gaaagaattg aaatgaaaat tggagaaccg ctttgaaaac tttatacaca 3276001 agttatccca aagataagaa caacttaatc acaagagata tccacatgtc cacaaactct 3276061 atctatattt tgtatacgaa cgtatattcc taactatata tatacacagg tttattcact 3276121 tatacacagg gttctgtgta taactccttc gttatacaca aacaaaatcc aataaatggt 3276181 ccaaatgaca caaggatttt tttgaatttt caagaaatat atactagatc tttcacattt 3276241 tttctaaata caaaggggga aacacattga aaaaggggat cagtcagcaa acgcctcctg 3276301 caataagcga tacgatcgga gcttatcttc aaaatgatgc gtgatggtca ccaccatgat 3276361 ttcctctgtt tcatacgcgt tactcaaagc taacagccgc tccttaacct gttctttcgt 3276421 accaacaatc attcgatttc gattatcagc aattcgtctc tgttcataag gagaatacgt 3276481 atttttccga acagcttcat acgaaggaac tccctctaaa ggaataccct gctctcccgc 3276541 caaaagtgta aaatcaagca cagccccaag ctcctctgcc ttctcctccg tgtcagcaca 3276601 aagaacaaaa acagcaactg ccgctcgagg cgtatctcct aacacagacg gtttgaatcg 3276661 cctcttatac tgtctgacag taccctctcc gccctctcca ttgataaaat gggcaaacat 3276721 atagccagcg ccagattcag ctgcgagcag cgcgctttct ccagatgagc cgagcagcca 3276781 cacatccgga gccgttgaaa tatgcggcgc agcggtcaga ttcggaaaac ggtgtttgtc 3276841 atccgccaaa tcatgcaaat acatggtcag ctccttaatt tgctgcggat actgatcagc 3276901 attgcgctta ccaccgtcat tcagcgccca tgatgcaatc ggcattcccc ccggtgctct 3276961 gccaagcccc aggtcaattc ttcctggtgt cagcccctcc agaacacgaa agttttcagc 3277021 tactttataa gcactgtaat gcggcagcat gactcctcct gatccaacac gaattcgctt 3277081 tgttttcgct gctatatgac tgattagcac ctcaggactg gaccctgcca gccgttttga 3277141 aaagtgatgc tcagaaaccc aaaatctctt atatccaagg tcctcagcag cttgggcaag 3277201 cgcaacggtt tgctgtaagg ccgtttctgc attgctgccc tctgatactg gagattgatc 3277261 taatatactt aatgaaacca tccctaccac ctcatcctca tcgtatcact gatcccctat 3277321 tttttctcca aagccgctca cactgcttat cagtgtcccc tatcattcgc catttatttg 3277381 tgaaagcatg tccctatttg tcggaatatg ttacacgtga aacataaaaa cccctccaga 3277441 cggagaggtt tgctttagtt tttattaaag cccttttctt tcacgtagtc atttaaatac 3277501 gtacgcggct tttgcttcat aaagttcagt atttgatcgg accacgtttc ttcccgcttc 3277561 ccgtttgttc tttctctata gtaatcagaa atggttttgt catacgtatt catagtatga 3277621 cggaaatcgt ctgtgttcac attatacgta ttttcatgat aaacggcctg ctttggcaat 3277681 ctcggttttt tgccggaaag gttcgcagga tggcctactg ccagtccgaa aagcgggagc 3277741 acatggtcag gcgtttgcag cacctctgtc accttgtcca attcattccg aatgccgccg 3277801 atatagcaaa tgccaagccc catggattca gcggcaatgc tcatattttg cgctgccagc 3277861 gccgcatcaa tcaagctaac cataaacatt tctgtattct cgagcagctc agaaatatgt 3277921 tcaccttttt cctcagccag ttgttgatgg cggtacaaat ccgcacaaaa tacaaaaaag 3277981 tgtccgttct tctcaacgta aggctgattc ccagcaagca cggacagctc acgttttttc 3278041 tcaggatcag aaaccccgat aatcgaatat gcctgcacat agctggatgt agacgcagcc 3278101 tgcgcacttt tcactaatgt atcaatttct tcagctgtca aaagctgatc agtaaaagac 3278161 cggattgacc gatgattcaa aatggtttcg attgtgttat tcatcacaaa aacctcctta 3278221 tcacttttta tcatatccga aaaaaagtga tctcaaaagt gaaatgctct gcacaaaaaa 3278281 agacagcctc tgtaaaggct gtctgcatat caagaattaa aaagataact tctgtatttc 3278341 gtcagctgca cacttgcatt atatacaatc ccaaatccga ttaacgtgga aagtgtcgag 3278401 cttcccccat agctgacaaa cagcagcgga atcccggtaa caggcataat gccaatgttc 3278461 attccgatat tctggaatgt gtggatcaca attaacgccg tatagccaac gcaaaagaaa 3278521 gaagcgaaac ggttaaacgg atgtattttg tctatcagaa caacaagcct gtagattaaa 3278581 aagaagaaca tgatgacaac aattgcacag cctataaagc caaatgactc acctattata 3278641 gaaaagataa agtcagtcgt actctctgga acataaacct tcaaattaga aataccatta 3278701 cctaaaatac caccagatcc tattgccatg atggcctggt caacttgcca gctgtcattt 3278761 gaatcttcct gtgtctcatt tgaagcagac acccaagaag tgacccgctt aatttgataa 3278821 tcctgtattc caactgattt agcaacgtca ggaaagttta tcattactaa taaaattaat 3278881 gaaatgagta agatacctga accagctatg atcgcaatca atttccaatt tatccctgac 3278941 ataaaaacca ttacaagaac gataaacata catattcccg cagtcccagc atcctgcatc 3279001 aggataagac ctacaggaat aactgcgaca cccgcaatct ttaataacaa gtggatatca 3279061 tccctaagcg tccgaactcc tttaggattt gcttttccaa taactgaagc aagcatcata 3279121 atcaaaccaa ccttcataaa ctctgacggc tgtattgtta ttctaccgat cctaaaccaa 3279181 ctttttgccc ctttaataac aggtgcaata gactcgggac tgattttaag aataatcaaa 3279241 gataaaatac caatgataaa aatatataaa cttaactttt caagctgttc taaatcaaag 3279301 tacaaaagaa ctgtaatggc tacagccccc aaaagataaa acacaatttg ctgaatccaa 3279361 tccgtgttcc catactgccc aaactgaccg gcagcatata ttgatactac gcttataata 3279421 aaaaacacac caaatataaa aatcaaatcc ccctggtaaa aggggctttg ctgtttctta 3279481 tatcgactca ttctatcccg ccttacattt tcatcggaaa atcactaatg tttattatac 3279541 atgaaccacg ttcaagatga cacgtgaagc tcgcttcctt ttatgttttt tcagcatttg 3279601 cggcgctttt tcagctacac gaaatatgac gtatcataaa ccgaaatgtt tcgattgaca 3279661 caaaactttt caaatgaaaa aaacgccata ccaatagaat ttgttaaaaa acgaatgcga 3279721 taatgtgtta tgttcccaaa taatgtgata cctcatatag aaatagctaa aaattcagag 3279781 ccccatgccc atacattctc ctagcacatt aaacgaaaaa ataagacgat agatccagtc 3279841 catttctgca aaaacacgta tcaatttctg gaaaacatgg tataataatt gtaacagaat 3279901 gttcaaaaaa caatcacaaa acagacacaa ctcagttcct ctatttcatt tttgtaaacg 3279961 ttatcacaaa atgaaaggag acgggtatga tggacatgtt ttttgcttac ttattggttg 3280021 ccagcgcaac gcctctcttt atttggcttg ataacaaaaa agtcgcactc tcagctattc 3280081 cgccaatcat tttaatgtgg gtattcttct tcttttacgc aacagaaagc ctttctccac 3280141 ttggacacac tctcatgatt atcttgtttg ccgttaacgt cattgtcgct catatcgccg 3280201 catttatcat ttacggcctt ccgtatcttc gcagaaagcg aagcagctga agacagcaaa 3280261 aaaccctctt ccactgaaga gggttttttg tattattcgt tatggcctga atgctctgag 3280321 tgttcagcgc ctccaggagg atttccgtcc atatggtcac catggtgata gtgagccgcg 3280381 aaaatccaga tggatccaag tacgataacg atcgcgccaa agaatccgaa cagcgtgttt 3280441 ccgacttgga tcgtgccgtt ttcgctctct gtcatatgca tgaacatgag aagctgcagc 3280501 gccgcctgaa tgaaggcgaa gccgaagata atccaaagtt ttgctgatga gctcaggtca 3280561 gtatacactg caacccatag agccagcagg gtcaaaacga tagacaggat aaaacctaca 3280621 atgtgtttcc atggaaagtg actgtgttca gcagatttgt ttgccatttt acagaccccc 3280681 caatcccatg agatagacac ctgtaaagat gaaaatccat acaacatcta agaagtgcca 3280741 gtacaagctt gagataaaga ttttagatga agtttgcgga gttaagccgc gtttcttcaa 3280801 ctgaatcaga attcctgtga tccagaaaat cccgattgtt acgtgagttc cgtgagttcc 3280861 aagtaaaaca aagaatccag accagaacgc acttgtactg agagccgctc cttcatgtac 3280921 atagtgaaca aactcgttga tctcgcatcc gacgaagccg gcaccgagaa gaagagtgat 3280981 aattgtccaa atgactacgc cttttaaact tccgcggcgc atttcatgaa cagcgatccc 3281041 gcaggtaaag ctgctgatca gcagcaagaa cgtcataatc attaccagat tgacttcaaa 3281101 tagttcgtct ggcaagacac ctccagctgt tctgttttta agaacgaaga aggttgcaaa 3281161 tagtgttgag aacaacacaa tttctgcccc taaaaagatc caaaacccga gaatattaag 3281221 tctgccggtt tcagattgat attccatagg cgcgttagaa ttgccgtgtt ctgcatgttc 3281281 cataactcac gcctccttat tcggaaatct ttctttccgt ctcttttatt tcatcaacac 3281341 taatgtagta gccgttgtcg tattcgaatg aacgcagaac catgcagagc aggactccga 3281401 tcaatccgac tacgcccatc cagtaccatt caaagacaag tccaaagcct gcgagaccga 3281461 aggcaacaga cataaagaac ggtctgcctg agttgcttgg catatggatt ttcttgaatt 3281521 tgctttcagg gtataattca gttttttctt ctttcatatg caggaatgca tcttgagatt 3281581 tgacttcagg aagcaccgca aagttgtaat gcggcggaat cgcagaagaa gtcgcccaat 3281641 caagcgtacg tcccacaccc catgaatctc cgctgatttc acgagtagag taacggaagc 3281701 tgtagtagat gttatagcaa aggattaaga atcctacacc catcatgaaa gctccgactg 3281761 ttgagataaa gttcaatgtt gtccagccgt cattcggtcc gtatgtgtaa atacggcgcg 3281821 gcatgccttg aagccccaag aaatattgcg ggaagaaaca aatattgaac ccgatcataa 3281881 agatccagaa gaaccatttt ccgattcttt cgttcagctt gtggccgaac atttttggat 3281941 accagaaaat aaatccggcg aaacaagcaa atacagtacc cgcaatcagc acatagtgga 3282001 agtgagatac aaggaagtac gtattatggt attgataatc cgctgctgcc atcgcaagca 3282061 taacccctgt aaccccgccg ataacgaagt taggaatgaa cgcaagcgcc cacagcatag 3282121 gtgttgtaaa gctgattcgg cctttataca ttgtaaagag ccagttaaag attttaaccc 3282181 cggttgggat tgagattgcc attgtcgtaa ttgagaagaa tgagttaacg gacgcactgt 3282241 tccccattgt gaagaagtgg tgagtccaaa ctaagaaact caatacagag atggcgataa 3282301 tagaaccaac catcgctttg taaccaaaca attgttttct tgcaaagctt gagatgattt 3282361 ctgagaaaat accaaacgcc ggaagaataa cgatatatac ttcaggatgt ccccaaatcc 3282421 agaacaagtt agcccaaagc atcggcatac cgcctgcttc caatgtgaaa aagtgagcgc 3282481 cgaacaaacg atcaaatgat aaaagtgcta atgctactgt aagtacaggg aacgcaaaca 3282541 cgataataac cattgtgatc agtgttgtcc atgtgaacat cggcatacgc attaatgtca 3282601 tgccttttgt tctcattttt aagattgtta ccataaagtt gatccctgtc atcagggtac 3282661 cgataccggc aatctgaagt ccgaggaggt agtagttctc acccggccca gggctcatgt 3282721 cgttacttgc aagcggcata taactcgtcc agcctgcgtt cggagaacct ccgataacga 3282781 aagaaatatt gaaaagcatc gcccctacaa agaacgtcca gaagctcagg ttgttcaagt 3282841 aagggaacgc aacgtcgcgg gcaccgattt gaagaggcac aacaacgttg ataagaccga 3282901 ttaagaacgg catcgccatg aagatgatca tgattgtacc gtgagttgta aaaatttcat 3282961 tatagtggtt tgagtctaaa aaactgttat tcggaagcgc tagctgggca cgcatcatca 3283021 gaccgtcgac accgccacgg aataacataa ttacagcaga tataatatac atgattccga 3283081 gttttttatg gtcaacagta gttatccatt cagaccacag ccatttccac tttttgaagt 3283141 aagtcagaac aaaaataatg gcaatggttg aaagcgcaat ggaaacttgt gcgcccagaa 3283201 ttaatgggtc accagttacg aaaaattcgt cccatttgaa tttcatgcag gcttcctcct 3283261 ttcctgatca atatcattct tctgtatcat cagacttctt aaattcgttt ttctttacgt 3283321 tttcaaacgg atctgtttta gaatgcggtg aaacggcttg atagccaagg cgtttgcgcg 3283381 cctccatcgc gtactcagcg tcttgtccgt gatcaacgta tttcaagtga gtagaagaga 3283441 acgttaattc gtccacattt tcaggaagca tcaattcatc atacttctct tttgtcagct 3283501 taggagcctc gttctgagtc tttttcaccc agctgttaaa gtctttttct gtgactgcat 3283561 tcacatcaaa ctcttggtct gcaaaatgtt cacctgtgaa gttcgcgttg cggccttcgt 3283621 aagtacccac tttgtcagcc tgtaagtatt gatccatcag cattcctgcc atcgcatatt 3283681 tttgccctcc aagctgagga atccatagcg aagccattga atctgcagat gagattttga 3283741 acaagatcgg gcggtcgaca ggaatgttta agtagttgac cgtttcaata tcctgttcag 3283801 ggtagctaaa tacccatttc cagtctaccg aagtagcata aacaacaaga ggctctttgt 3283861 cttttgttgc ttcaggagct ttttctaacg aatatatcgt ctgtactgtt ggcacagaaa 3283921 gtgcaatgac gattaaaatt gggatcactg tccagactac ttctaaaaac gtgttaccgt 3283981 gaatttctgg gttataagat ccattatctt tgcctttacg gtcgcggtat tttactaaaa 3284041 taatggtaaa tagaacaaag acgaccccga cgataaacag cataaatccg atagataaca 3284101 ggattaaatc actttgctgt tcagctacag gtcctttcgg atctagtact gaagcattgc 3284161 tgcatccccc aaggacgaaa accacagtta acagcgctaa tacaagcaac ggttttaatg 3284221 ctctgaacaa gaagatcacc atccttccta ttgatgtaat aaatctgaag tgcatacttc 3284281 ctcaaaatct tttctctact ttgttatgct atcaaaaact tcacttatta gctttatttt 3284341 tttataaact tcatcccatt ttcgcttaaa tgtcataaaa tcgacaaaaa ttgctccaac 3284401 tttattcaca tctatcgctt aagatgaaaa gtttctagtt atttccgcat ataaagtaaa 3284461 gaaagatgat gaagaactaa ttctgacaaa ttaaggttta ccacaataaa aaacttaggt 3284521 caatcaaaaa tttcattttg ttaaactttc tagataggaa ttattttttc ctcgtctagc 3284581 atcttttcac acggttacca ttttaacgca tcaaatattg aaagaaaagg cgcaatgaag 3284641 agccaatatg ctctgaattg tccgtatttt tttatgagag catccagttg tttatcttat 3284701 acaaaaaaga ggaatgatat aagcaaataa ataaaaaata ggatgtgttg catgatgagt 3284761 tttcttattt cacttatcgt cgctattatt atcggatggc ttggaagcct gtttgtaaaa 3284821 ggagatatgc ccggaggaat tatcgggtct atgatcgcag gtcttatagg cgcctggatc 3284881 ggacacgggc tgcttggaac atgggggccg cacctagccg gatttgccat tattccagcg 3284941 gtaatcggcg cagccattgt tgtctttcta gtaagcctgt taaccagaaa aagaggataa 3285001 aagcagcagc acccgaagcg tcagcgcttt gggtgtttgt tttgccataa aaatcgaaaa 3285061 agcctcaacc ctagcggttg aggcttttga ctggtttggc gcccaactga tcgatgaacc 3285121 ttctgaaggc ctgttttccc tctgctgtct gcttaaatac accggcgtgt tcaaggatgc 3285181 gcgcgaatac atgtcccagc tcttctttta tgactagatc tacgttctct tttgttatgg 3285241 ttcttttttc catcgtccga agagcccact cactatgctt tgcagtgagc ggattttgtt 3285301 ctaaggctgt tttcggatca gcagaacata gcgccgctgc cgtttctttc atttcctcct 3285361 gtaagcggcc aggcaatatc gccaatccca tgacctcaat caggccgata ttttcttttt 3285421 taatatggtg gacttcttga tgaggatgaa atattcctaa tggatgctcc tcatccgtcc 3285481 ggttgttcct cagtacgata tcgagttcgt acaagtctcc cctgcgccgc gcaatcggtg 3285541 tgaccgtatt atggggcgta tcgcctgtat aggcggcaat gccggctttt tcatcggaat 3285601 acgtctgcca cgtgcggaag atatggtcag cagcttcggc gacatgaccc ggttcgtctc 3285661 cttggagcct gagcacagac atcggccact tcactaagcc cagcgacacg ccgggataat 3285721 catttaattc ataaacgtct tccgcttctg cacgtgccat tggaaaatca tgcgcgccgc 3285781 cttggaaatg atcatggctt aggatgctgc cgccgacaat cggcagatcc gcgtttgaac 3285841 cgataaaata atgcggatat tggccaagaa atgacagcag cctttcaaat gtttttttgc 3285901 tgatctccat cggttcatgt tcacctttta agacaatgca gtgctccgga taatagacat 3285961 atggcgagaa ttgcaggaac cattgttcgt cctcaaggat gaccggaatg attctgtgat 3286021 tttgccgggc tggatgattc acgcttccct cgaagccgac attttcttta cacagcaaac 3286081 acatcggata atttgtctgt tcctgctctt ttgcagccgc aatcgctttc gggtcctttt 3286141 caggctttga taggttaatg gtcatttcca gctcgccata ttcggtcggc accgtccaat 3286201 gaacattttt ggcgattctg tcagtccgta tataatagac atcctctgaa tattgataga 3286261 attcctttgt cgcctgtttt gggccgtata atgcttttgt ctcttcaaat ttgcgaatga 3286321 cctcggacgg ggcaggcaca aaacagccca tcagctttgc gctgagcagg tcacggtacg 3286381 tatctgtatc cgcttccatt cggccggttt cggcagccca tttatagatg ggagctagca 3286441 agtccggcag gctttgtgac tgcttgatgc tggtgctgga gttcggctcg ggatgtgtga 3286501 tgcccagcgc ttcataaaga cggtttctcg tatattcccg atcccagatc gaaatcaatt 3286561 ttcgttccag gccatactca agcagctgtt ccagatgttc aataatactc atatgtcact 3286621 ccccctttag ttctctcgct ccctctccga tatccgcgac ataaaagtcc gctcggagcc 3286681 ctgttttttc ttgatatctg tctccaacct tctgaataaa atcatcaacg aactcatctt 3286741 ttacaatgct gatggtgcag ccgccaaagc ctgctcccgt cattcttgat ccaattacac 3286801 cttcgtgatc ccatgccgca aacacaagct catcaagttc agggcatgtt acttcatagt 3286861 catccttcaa tgaaaggtgg gattccttca ttaactgccc gatttcatct atattgttct 3286921 ctttgaacat atgggccgtc ttaatagcac gatgattttc gtatacagcg tgctttgccc 3286981 ggcgtctgtt cgtttcattt tggatcaggc tggaatgcgc atcgaaatca gaaggcttga 3287041 tgtcgcccag tgcggcaata tcgaggcctt ttttcagatc aagcaatgca tcattgcatt 3287101 cttggcgtct cgtattatag ctggagtcag ccaatgtcct ttttttgttc gtgttcgcga 3287161 tgaccagcgc gaggcctgag acattgagtt tgctatattc atagtcaagc gtgtcacagt 3287221 tcagcagcat cgcatgatgt tttttcccca ttccaattgc aaattggtcc ataattccgc 3287281 aattgacgcc gataaaatgg ttttccgcat gctgcgccat tttcacaagc tcaagcgcat 3287341 ctacttcagg atgaaaataa ctttggagca cgacccccat cagcagttca atagaagcgg 3287401 aagacgacag tcccgccccg tttggaatat tccctgaaaa tacaatgtca aagccatggg 3287461 gaactgcata tcccctctgt tgaaattcat aaatcacgcc ttttgggtag ttcgcccagt 3287521 cgtcttcttt ttgatagcga atgtcgtcaa ggctgcattc cttgatgcct gcgtttctaa 3287581 agttatctga atacatccgg acaagcccgt cgtttctttc tgcaacagca gcatatgtac 3287641 ccattgtcag cgcgcacgga aagacatgcc cgccgttata gtctgtatgt tctccaatca 3287701 gattcactct tccaggtgcg aaaaaaaacc gtaacccctc tttttctccg aatacacttg 3287761 caaatatccc ctttagctct tcccgcatgt gcaatcacct ttctggtttt tattttttat 3287821 tccccttatt tcttcataga aaacggcaga tcatatgctg cagtcctctc ataccccttc 3287881 ttcttttgtt tttttaaaga cgagccattt gctcgcaaca tagttgacga caacaatgac 3287941 cgcgttgtcg agtattttgg ccaaggtttc atttgtattg aactggccga caagaatgat 3288001 catcatgcct aaatctatgc cgagagacag gacccgaacg ctgaaaaaag cagtgagctc 3288061 tttcagcagg ctctgcagat catgtgtttt ttgctgaaac acatataatt tatttgttat 3288121 gtaagcaaac agcacggaca aaatccaagc ggcaacagtg gcggctttgt aatccacatt 3288181 catgatctct accaatatat aaaagctggc gatattcaca atggttgtga aaacccccat 3288241 aatgatatac ataattattt ctctatactt cactgatgtt cctcgctttc tgaaaaactt 3288301 ttcaaaattc ttggcctctc gtgctctctg tctaaagtaa aaaataccga gagtgcgtct 3288361 aaaaagctgc ggaaggtggc tggctggccc aatacatatg attgtttgat gattccgtcg 3288421 aggactgcac atattatttt agccgtatat tcaggatcaa tacaggcgtc aatcagcttt 3288481 ctctccttca gccacttaat atataacaca ttttcttcca cccacaattc gtacagccgg 3288541 acataggcct tgcatttctt taagacttta tatgtcggca tgttcatggc aaacgaggtg 3288601 atgtcccacg acggcttatt tatgtaatag gaataaagca gttctgcagc gtgttttgca 3288661 gcctcgtcca atgtcagcga tttcactgac tcccgctcca tttgatcaag ataccctata 3288721 atgatctttt ttttcatctg acgtttttcg agaaggtaca gcagaaaatc gtccttgctg 3288781 acaaaatgaa cataaaatgc tcctttgctg tacccggcgg ctctgctgat atcttctaca 3288841 gaaaccggat catacgctcg gtcaatcaac aaattcacgc cagcgtctat aaaactttca 3288901 aatgttgctt ctcttttaat ttgaaatttg ttttttttca tatttttctc ctggcggtaa 3288961 tgattaccct tatcttacac cggatcaatc tttagcggta tttatttctt taaacggtta 3289021 tgctattcgg tttcccaggg gtcattttta ataggctaaa tgatttattt tcatttacat 3289081 actatccagt cagtatttaa ttgtttatta ttataaataa ggtccattgg ttatattagt 3289141 cattttttta gggaataggt aggtggtttt tccttcagtt tgtgaacacc gagcaactat 3289201 gtgtgaaatt tgttgtactc gcctccatca tcgcgctggc ttgtctttta ttgcccgcat 3289261 gttgcaggaa aacattttat acaattggag gttactatga aaactcatgt taaaaaagat 3289321 ttggacaaag gttggcatat gttaattcaa gaagctagat ccattggatt aggcattcat 3289381 gatgtgaggc agtttttaga atctgagaca gcatcaagaa agaaaaacca caaaaaaacc 3289441 gtccggcaag actagtccga acaggcggat ctatttacct ctggcttttc tatcacctga 3289501 tctgagtttt caccatatcc tctattcaaa agcaaatcgc tgcgctgagc ttgaggacaa 3289561 acggtgtgtc agctaactac gacagacagc cggtgatgcg atcacctctt ggcacatgca 3289621 ttgtcataaa gaggtgatgc gaacatgata accgtgctct ggtaaacagc agctttgctg 3289681 agaacaagct gcattcggtg aggttttgaa agcaaactcg tttatacacg gccgagcttg 3289741 aaaaccttcg cctgtcttta gaccactgtg ttcacctctt cacgacttcc ttcttttttc 3289801 atcctccagc tattgtacaa cgcataaatc ggactttcag tacataccta ttggtgtacc 3289861 tttttgctta cgtttagcga ataaaaggag gaaagccatg tacaaagctg attataaaca 3289921 gattgctgca acgccgtctt ttcaagcttt tttaaagcag aaacgcgctt ttattgttcc 3289981 ttctgcgatt ttcttttttg ttttttattt ttcactccct gttttgacat cttatttcac 3290041 ctttttgaat gcaccggcca ttggagctgt ttcatgggct tggctgttcg ccatcgccca 3290101 attcgctatg acctggatac tgagtactgt gtattcccgg agagccgccc atttcgataa 3290161 gtatgtaagc gctttaaaag aggatctgaa gggtgaacag acatgaatat gactgctttt 3290221 ttattatttt tggcgattgt tggcctgacg cttattatca cgtattttgc cgcgaagcgg 3290281 acgaaaacga cgagtgagtt ttatacggcg ggcggcgggc tcaccggcgt tcagaatgga 3290341 ctggcaattg ccggtgacta catgtctgcc gcctcgtttc tcgggattgc cggaatgatt 3290401 gcgttatatg gatttgatgg cttcttttac agcatcggtt ttctggtggc ttatctcgtt 3290461 gtcttgtaca tcgtggcgga gccgcttcgg aatcttggaa agtacacgat ggcagacatg 3290521 attgccgctc gctttaaaga aaagaaaatc cgcggtgtcg cggctctcaa taccattgcc 3290581 atctctactt tttatatgat cgcccagctc gtgggggcgg gcgcgctgat caaactgctt 3290641 ctagggctgg attataccgc ggctgtcctc atcgtcggag tgctgatgac catttatgtc 3290701 gtgtttggcg gcatgatcgc gacaagctgg gttcaaatta ttaaagctgt tttgctgatg 3290761 gccggcacac tcgtgatttc gattatcgtg ttttcgaaat tcggctttag ccttaatacc 3290821 atgtttgaac agatgaaaac ggctactccg cttggcgctg attttttgaa ccccggaaat 3290881 aaatacaagg tgccgcttga gaccttgtcg ttaaacttgg cactcgtgct gggaaccgcc 3290941 gggcttccgc atatattgat ccggttttat accgttaagg atgccaagac ggcccgtaca 3291001 tccgttgtgt cagcgacatg gattatcggt gtgttttaca ttatgacggt atttctcggc 3291061 tttggtgccg cggcatttgt cggttttgac gcgattacgg cggctgatca agcgggaaat 3291121 atggcggctc cgcttttagc aaaagcgctc ggaggagact ttctgttcgc gtttgtatca 3291181 gccatcgcct ttgccaccat tttggctgtc gtgacagggt tggtgctgtc tgccgcctca 3291241 gcatttgccc atgatattta cagccagatc atcagaaagg gagaagcaac tgaaaaagaa 3291301 caaatgaaag cggccagatg ggcttctgtc gccgtgtcag tgctctcgat tctccttgcg 3291361 atttttgcac aatccttaaa tgtggcgttc cttgttgcac tcgcgtttgc ggtagccgcc 3291421 agcgcaaacc ttccgctgat tgtgtttaca gtcttctgga aacgattcaa tgcctcaggc 3291481 gctttatggg gcagcctgac aggcctgatc agcgcgcttg tgctggtatc gatgagccct 3291541 agtgtgtggg acccggccgg aggtgctatt tttaccggtg atccgctcat tccgctatct 3291601 aatccaggaa ttatttccat cccgctcggc tttctcggcg cgtggctcgg aacggtgctg 3291661 tcgtctgata aaacaattga tgaagatacg tttgcagaaa ttcaggtgaa ggcgcatact 3291721 ggcgtccata tggaacagga ataaaaaaag ctctctttat cgagagcttt ttccttactt 3291781 tttcttctgc tcgtcagaaa tcgctttttc aaatacatcc ttgccggcag cacccggaat 3291841 tacagtgtca ccgataataa aggttggaac ggctgtgatg tcagcctctt cataggcgtg 3291901 cttcaaggct tggcgctgca cgtcctgata tgttcttgtt tccagtgctg atttgaatga 3291961 tgcaccgtct aatcccactt cctcggcgag cttcgtcaag atgtcaatat cgccgatatt 3292021 ttggtcctcc tggaaaaatg cctgaaagac acgggtgttg tattcatgtc ctttattgta 3292081 ttccttcgca aaatggaagc cttcaaacgc gaggtctgta tacggatggg gcgagacgtt 3292141 tggaaaattg atctcgactc ctaatttctc cgccattggc tgaattgatg tctgccacat 3292201 gtactgttta gaaggatcat tgaccggatc aagctgagga gatgggcttg ggcgcagttc 3292261 aaacggcatc cactcgactt caacatcctt tccttttatc gcttcttcaa aagcggcttt 3292321 tccaacaaaa caaaatgggc agacgtaatc tgaataaact ttaatgtgta ctgtcatgat 3292381 aatctccttt catactaaat tgattttaaa ctgtaacaat taaagttaca actgtttttt 3292441 aataaagaag ccgatttagg cttctttcag attgatgaca aaatcctaaa aagttttagg 3292501 attttgtcat cctttcagcg tgattgaaaa cccttgaagt ctaggaaagc cgagcattgg 3292561 agcggagcga atgctctaat tcgtgagcac caacgcacag gcttgacaac gaatgcgagg 3292621 gtttgtcgac acgctgaaag aagcctgtaa aggcttcttt tatgattcca gcaaacgctg 3292681 ggcaatatat tctccttttt tgcagccgcc tgggcatgcg tataaagcag aaccgattgt 3292741 ttgtgtatat tcgtttaacg catcctttgc tgaaagagcc ttcagcatcg ggataaactg 3292801 attgtcggga tttttttgaa aactgataaa caggagacct gcatccatat agccggtttt 3292861 cggatcaagt ccttctgtgt aagagaaagc tcttcgcaaa atttgtttcc cagtagattt 3292921 cgctagactg acgtgtgaat tagacggaat ttgattcagc ttcacgggat ctgtttcctt 3292981 tttctgccca aaaggcgccc ccgagctttt tctgcggccg aaggtatcct cttggtcctt 3293041 gagggaagag cggtcccata cctcaaggaa cattttgatt ttccgaaaag ccatataggt 3293101 gccgcccgtc atccagtcag gctcaccaga ctgaatccac acgatcgagt tcatcaacgt 3293161 gtcatccttc gtgctctggt tgcctgttcc atctttaaac ccgaagaggt tgcgcggtgt 3293221 ttcaccattt tttccaccgc ttaaaaagcc tttgttcaca aaacggacct cacaagtgcc 3293281 gaccgcttga tttagcaggt tacgcagcgc gtgaaacgcc acttgctcgt cgtctgcaca 3293341 cacttgaatg cagatgtccc cgcctccctg cttttcatcc aggttgtcat tgggcatcgc 3293401 tggaagagcg gctaggtgct tcggtttttt gcttttcagt ccgaagcggt cctttccgtc 3293461 tttttcaaaa aagccaggcc cgaatccgaa tgtgaccgtt aagttggaag gggataaatc 3293521 agcagactca cctgtatcct gcggcggcag atactgattt ctctgctccg ctgacatttt 3293581 cttgccagac gtcagcatct gtgtgagact tgtccagttt ctaaataacg taatgatgtc 3293641 gcttttgtct tttgctgtta catccagtgc agcaaaatag acatacgtct gatgggcagt 3293701 tgtgattccg gcctgatgct ttccgtaaaa cggaacaatc tgctcctcct ctttttcatc 3293761 ctttttcgat ggcttagccg cagtctgaac aagcggagcg agaccgccga gaccgctggc 3293821 accgatcgca acggctgccc ccgccatcgc tccccatttt aaaatgtccc gtctgtgaat 3293881 ttgttctggc tttttctgtt catcgctcat gatgttacaa aactcctttt atagcacatt 3293941 cgcaatcttc gacatggttt cagaaagagt cgtcagctta gtgctcagct ctctgatttg 3294001 cttttcactt aatttatcat aagacgtata ggactgatca tttgttttgt attttgccat 3294061 taaaacttca aattcgctga actccgtatc cagtttttcc gtcaagtcgg agtgatcttt 3294121 tacaagcgcg cttttcactg tttgataaac ggcttcggag ccttccacat ttgccataag 3294181 gtcaactaaa tcaattcgtg agtagcgctc ttcttctccc gtgattttcg aaattccggc 3294241 ttcgttcaga agctccatcg cgcctgcaac aatttgttca ggtgttaatt tcagtgattg 3294301 aattgaaccg tcaagctctt ttacatcctt gagaagctgg tcagctgttg ccttttcccc 3294361 ggaaatatct tgatccttcc aaatggcctt ctcaagctta tggaagcctg tccatttgtc 3294421 tccttcttca acatcgtttt ctcgtgcgtc aattttcgga tcaagatctc cgaggctttc 3294481 agcgatcggt tcgattcgct cgtaataaac acgcgctttc gcatataacg ttttggactt 3294541 ttcgatatcg ccggatttca cagcacccgt aaatgcttca gtcgctttga caagctggtc 3294601 actctgctct ttgacatagc ctttatactc atccgctgct tttgccagct gatcgctagc 3294661 ctttttgccg ctcttcttcg cttctgtcag gtcttctaag gatgctttca atgactcgga 3294721 ttctgtcttg atttttcctg catccggttt gtctttttgc gcttctgtgt agattggctg 3294781 aagatgcttt tcgatttctg tatattcgaa tggatagtcg ctgcgaatat cgttttcaaa 3294841 ggaaagccag tagctgttta actctttccc cttcttttca atctcttttt ggtctccttt 3294901 ttccactgag tcattcagct tagaaatgat ggtttccatt ttatttacgg atgcggtgat 3294961 ttctttagtg accccgcttt tttcagatga agctttttct ttggttgaag atgtgtcatt 3295021 ggctccgcag cctgcgcaca gcgcaaggat gcatccggct gatacagcga tttttgtgaa 3295081 attcattttg tcagttcctt tccgtttgta aaatgttttg ccgcttctga aacaagcgca 3295141 atcagtaaaa agagtaaaat caacatttgc ggaatcgtgc tgtacacaga cggataaatt 3295201 cctagcaccg atacagacgg cagccagctt tctgcatcag acggaagaat gcccgccagt 3295261 tgaaggctgt gaacgccggt tccgagaaat ttcacgcaca tatacaggac aaccgccatt 3295321 gatagaagaa aaaacggctt caatggaatg cgcattccga gcttgatcat cagaacaccg 3295381 acgatgacga gaacgataag ccctgcggca gttccgccga tcagttcagt gagcgggagc 3295441 ttcccgacaa gcccgatgaa aaagatgacc gtttcgagac cttctcttac aactgccaga 3295501 aatgcaatga gcgcaaagga aagcaggctt cgttttttta gtgcctgtga cttctggata 3295561 ttgatttttt ctctccattt atccattgag gcgtttctgt gcagccacac cccgacatac 3295621 aaaagcatga cagcggacag tacgccggta acgccgccaa gcaagaaatt gttttctccg 3295681 aatacactgg aggagaacag aaccgtgaca ccgatgccgg ctgctaagga aacagccatg 3295741 ccggcggacg ccccgcccca gatccatgtc gaggaacgcg taacccgcgc tttttttgtc 3295801 atggttaata gcgctccgat gacaaggagg gcctccattc cttcacgaac cgggatcagc 3295861 gccgcatccc accagctgta gctgcttgaa gcgatcggct cgagcaattg aatcatttcg 3295921 tcaatttgct ttgatacctt ttcaggatgg ctgccgatct ccgccttcat cagcgccaga 3295981 ttttcctccg atgtcgtata ggcttctttc gattgggaca cgacatctcc ctcaacagcg 3296041 agccaggatg taactaaatt gtcgattgcg gatgacgctt catccaattg ttttttttct 3296101 atgaactgtt ttgtgtcttt caagctttgt atataggctg ttaaggacgc ccttgattga 3296161 cctgaggatg tctttttcag cacgacagcc tgctgatagg tttctaaatg agacgcaagc 3296221 tcttcaagct gtgttttgag cttacgtgcg tcttgattga taaaagaaag agaaatcatc 3296281 gcgatattcg cgtccatttc actgtgagaa gaaaggtttt ctttcttaat agaaggttct 3296341 tcttttttcc acttcgcctt gaaggtgtca aacgtttgtt gtgccgaatc catatccccg 3296401 tcttttacgg atttgatcat ttgcttgttt aattgaatta atgcggcgat cggatcatct 3296461 tccgcatgtg ccgcagaacc gaaaaccatc aacaagctga atagaataag tgccagcccc 3296521 cgagccatca tgttcctcct ataattgaaa atgattatca ttgtataaca taatcatagc 3296581 cagttcctgt cctttgtcaa ttaaaatttg aaggtctgaa aaccttgatg gacagcaaaa 3296641 aagctgtcct tttacagaac agccctttga aggaaaatga acgattatct tcctgtttta 3296701 tacgtttgaa tttcctcacg aaacttgcgt gcagcactct caggatcctc cgcctgactg 3296761 atggcgctga tcatactgac gccatcggcc cccgcttgga taacaggtgc ggcattatct 3296821 attgtgattc cgccgatgcc gacaattgga atgctgatgc cttggcggcg cactgcttcg 3296881 ataagagata caccctgtac cgctctcgta tcttttttcg tttcagtcgg atagatcggc 3296941 ccaagcccga cataatccgc tccgtcttct tcggcttgct tcacctcaga catcgtatgg 3297001 gcagaaacgc cgagaatcat atcacctatg gcagctctta cctctttcgc atttgcgtct 3297061 tcctggccga tgtggatacc atcagctttc agattcagag ccaattccac atcatcattg 3297121 acaatgaacg gaacaccagc ttcacggcaa gctgcctgcg ctttttcagc aaatttaatc 3297181 cgagcctctc ctgtcagcgc atccccgcct ttttcacgga actggtacag ggtggcaccg 3297241 ccttttaacg ctttttgtac aactgtaaca ggatcggctt tcgtattgtt tgaccccata 3297301 atgaagtata cagataataa ctctttcatc atttcccgag aaatacgagt catgagacag 3297361 tcaccctttc tatagtcgcc cattcttgga cgtcttgttc agtaacagtt gaaagcttgt 3297421 tcagcaattc aatctgaaag cttccagggc ctttgtcagc cgtctgctgt gcggcaagct 3297481 gagcggcgac cccatacgaa gaaatggccg caatagcagc aaacaatgga ttttcttcca 3297541 cagcgcaaaa cgcaccgacg acggaagtca gcaggcaacc ggcgcctgtc acttttgtca 3297601 gcagcttgtg gccgttatga agggtgtata catgtgacgt gtcggctatg acatcaactt 3297661 caccagttat cgcaatgacc gtgtttagct tttgtgccgc ctgctgagcc agccggatga 3297721 tgtcgcctcc accttcaccc gcatcaacac ctttgatcag ccaatcggtc acgccgacgg 3297781 tatgggcaat ttccgccgca tttcctctga ttgcagcaag gcgcacctca cgaatgatgt 3297841 cacgtgccga ttcagtgcgg aacggtgttg ctccggcacc gacaggatca agaatgacgg 3297901 gaacgccatg ttcattagct gattttcccg cgatgatcat cgcttcgact gactccttgc 3297961 tcagtgttcc gatatttaaa acgagtgcac ccgcaatttt cgccatatcg gcgacctctt 3298021 cttttgcgta cgccataacg ggcgatgcgc cgagcgcgag caggccgttt gctgtgaaat 3298081 tcgttacgac attgttggtt atgctatgca ccagtgggct atgccggcgg acagccgtaa 3298141 gacattttgc tgctgattgt gcatccatat ttgcatcatc ctttactatc ttttttcggg 3298201 tcccataaat acgatttcgt atgttcgagc caagctctgg cggcaaacga caagtacctg 3298261 tcctttctcc aaataatggc gaggtgccaa gggatgaccg gatcgacaag cggaatgact 3298321 ttcacttttt ccgggtcaag gccgcggcag atccgttccg gcaaaagccc gatcccaagg 3298381 ttggcggata ccatctcact aataaaatcc cattgtgatg tttcataaat gatatggggc 3298441 cggaacccag ccttgataca ttccgtcata attcggttgt gcaggacaaa atcctctctg 3298501 aagaaaataa aaggctcgtc cttcaactca cgcagctgac attctttctc atcagccagc 3298561 cggtgggaag ggtgaacgac aagcattaag gtttctttta cgattgtaaa cgaatgaaag 3298621 atatcttcgt ttgcgggaag gaccacaacg ccgatatcaa gagagccgtc cccgacacct 3298681 tcttggactt ttatagaacc gtcttcgact agctgaaagg tgacattcgg atagttttca 3298741 cggaaatcgc cgagcactct ggggaaaaac cccgatccga tcatcggcgg cagtccaatc 3298801 cgtacgtgcc ctttcttgac ttccataata tcatttaatt ctgacgtcag gttttgaaat 3298861 gatttaatga tttcctgcgc ctgcacatac atgctatgac cggcatcagt cagttccacc 3298921 tgcctgccgt ttcggtaaaa cagttcaatt ccgagctctt cttctaaatt tttgatcatt 3298981 tttgatatcg tcggctgaga aacataaagg gattgggaag ccttcgtaaa actttttaaa 3299041 cgggcgactt ccaagaaata tgttaaatgg cggatatcca tgcgcttcac cctttctata 3299101 gacaaaagga atacttctta ttcttaatat atattttacc tatagagaga ccttatgtac 3299161 aataagtata taagggaggc atcaatatga aaaaactgtt gctaaccgtt attcaaatcg 3299221 ctctgttatt tatatttgct cggctgatta attgggtgac agcccttctt catataaata 3299281 ttcccggcag tataataggg attgtgattc ttttcacatt attgcacttt aacattatca 3299341 agcttgaatg gatcgagctt ggtgcagcgt ggcttctcgg ggagctgctt ttatttttta 3299401 tcccgtctgc cgtcggagtg attgaatacg gagacattat gtcgaaattt ggtgtcagca 3299461 ttctgcttgt tgtcatcatc agcacgtttg tcgtgatggt gtctacagga acgcttacac 3299521 aactcatcgc aaagagaaag gagaaaaagc atacgtgttc atcggaattg taagtttgtt 3299581 tttaacggtt ttggtgtatt taggagcaaa aaaggtatat caacgctttc cgcgtgttta 3299641 tacgtcgccg ctattggtga cgcccgctgt attagtcggt ctgctgctgc tggtgaatgt 3299701 cccgtacgag tcctataatc tcggcggcgg attgctgacc gatatgctac agccggccac 3299761 cgtggcattc gcgatcccgt tatataaata tttccctgtt ttaaagaaat acgcagtgga 3299821 aattattttg aatgtggccg tcggttcatg catcgcgatt atttctaccg ctcttattgc 3299881 gaaatggctt cacctcggca ccggcttaat tgacagcctc gtcccaagat cagtgacaac 3299941 gccgatcgcg atgaacgtat ctgaaatgat cggcggtatg cctgccgtca cagccgtgtt 3300001 tgtgatttta accgctttgc tcggcacagt gatcggcccg atggtcatcc gttatttccg 3300061 cattgataac gaaattgcgc ggggcgtgct gcttggcaca agcgcgcacg gagcgggaac 3300121 gtcaaaggca tttgagctca gctctgtgtc cggcacgatt tccagcgtgt cgatgatctt 3300181 agctgcgatt atgacgcttt gcgcggcgcc gtttttgctt tcatttatgt aaaaaactgt 3300241 cctctcgagg gcagtttttt ttatgtgctt ccccttattg aaaagctggc gaattccaat 3300301 ataatgtatt tgtggatacc aaaggaggca ccctgatgca caacttgcag gtgaggcggc 3300361 attatgccgc gttaaaagga ttttatttgt ttgcttttct cggtacgggc agcataattc 3300421 ccttactcag tatgtattta acgaaggaac agcatttaag cggatcacag gtcggcttga 3300481 tcatgtcact gggcccgatt gtgatgattt tctttcagcc gttttggggc atgctgagcg 3300541 actatacgca aaaaacgaaa ggcctgctgg cggtttgcac atcaatcaca ggcatcattg 3300601 gattagccta tattgcattt gacagtttcc ctctgtttat tttgattgcg gcctgttttg 3300661 cagcctttca aagcacgatt attccacttt cggacagcat ttcactaagg tacacacaag 3300721 aaacaaacgg caactacggc ggaatccgcc tgtttggttc tctcggcttc ggtgtcgcgg 3300781 tgtttgccat gggacaggtg acgaaccagc tgtaccccat tcacgtgatc tttatctttg 3300841 gctgtgcctt tctgtgcatt gctgccatat tggcttcaca agtgcccggc cagcagaaaa 3300901 caacaaaggt caatatccgc aaaggattcc gggagcttat cagcaacaaa actttcctca 3300961 tctttatgat catcaccttt acgacatttg ctccaaactt agcgaacaat acgtatttca 3301021 gtctttttct ggacaaaagc ggcgcgtcac tttccgctat cggcatttta tttttcatcg 3301081 gtgtcatttc agaaattcca tttatgagat tcgcccaaac atttatagat aaaatggggc 3301141 tgctcaacgt cattatgctg tcaggcggag tctcattatt caggtgggcg ctctatttca 3301201 cggcgccttc actatggatc atttatgcga cggtctttct tcagggagtg gccatcggtt 3301261 tatttatccc ggcggcgctt caatatgtga aaaagattac cccaagacac gttgaagcga 3301321 cggcgctgac catgtacgcc gccattggca acgggttcgg caactggttc tgcacatttg 3301381 caggcgggta catttttgac tacgtgtcga tcttcgcagt ctacttgctt tttggcattc 3301441 tgagcatagc aggctttggc ctgacattat atttaatgaa ggctgaaaaa aacaaacata 3301501 cacttcatca gccggctgtt acttttaaac cataatgact ataatgaaca aaagaaagga 3301561 tgtgcgttat gaacgggcaa gagcgaaaca gcatttcgaa agggttgcag gttgatattg 3301621 tattgaaagc agatcaaaaa acaggaaaac tgacgagagg gacagtgaag gatattttga 3301681 cgaaatcaaa ctttcatccg catggcatta aagtccgtct tgaagatggc cgcatcggcc 3301741 gcgaccagca gatcgtttct acataaaaaa aagctgcccc tgaacagggc agctttttca 3301801 ttattttttc tgcagaagga ccactttcag gtagttgcct tccggaaatg ccgaaatcgt 3301861 tttgaaatcc tccggcagcg taaattcctc aatgatcgtg tagcgttcat ttgtttcttt 3301921 aaaggcggca tcaataaagc ctttgaactt cttcatgcca aaggcgctgc tgtttgtaga 3301981 ggcaacaatg acacccttgt cagcagtgat ggcgatcgtt tccttcagca ggtttttata 3302041 atccttggcc gcgctgaagg tgcgtttttt tgtgcgcgca aaggaaggcg gatctagaat 3302101 aatcagatca aagcgcaaat ccttttttgc agcatatgaa aaatagttaa aaacgtccat 3302161 cactttaatg tcgtgcgctt cgtaatccag cttgttcacg ctgaattgct cgatcgtttt 3302221 ggcaagactt cgatttgcca cgtcgacgct tgttgttttc tccgctccgc caagcgccgc 3302281 cgccacggag aatgcacccg tataagaaaa cgtatttaaa acggttttcc cttttgcata 3302341 gcggtctctg atcgccttgc gcacatgtct ctgatccaaa aagatgcccg tcatggcgcc 3302401 ttcattcaga tccaccgcgt attgaatgcc attctcttgg atgatgatcg ggaactcgcc 3302461 ccttctccct ttcacgaagt catcatcttc aacgtattgt ccagccgtgt cgaagcgttt 3302521 cttctcgtaa atcgctttat aatcaagatc catctcatcc aatgcggaaa tcagcatgtc 3302581 tttaaaggtg taaattccct tgctgtacca ttgaatcagc aggtagccgt cataatagtc 3302641 gatggtgacg ccgccgacac cgtcaccctc accgttgaac aggcggaaag ctgttgtatc 3302701 ttgagcctca aatagtttgg cgcgcgcttg ggccgctttt gttaatttgc tgagaaaaaa 3302761 tgcttggtca atctgttcat gtttattgcg ggtaagcgtc cagccaaccc ctttgttttg 3302821 caggccgtaa tagccccgcg cgagaaactc gccgccgctc tcagacacga tatcaacgag 3302881 gtctccttct ttcatgtgcc ccgcactccc tgcgagagct tctttttcaa taaggggata 3302941 gccttttttt attttggcag cgtgtgcttt ttttagggtg agtagcttca tatatgtcgt 3303001 cctctttccg tttgctttct cttatggtac cacaaaacgc caagatgtct gcattgacag 3303061 aaaggaaagg tttttctacg atagacaaaa agagttacga ggaggagcag catggcaaaa 3303121 cgaattgacc atacaggcat catggtaaga gatattaacg cgtccatcac attttatgaa 3303181 gaggtactag gcatgaaatt gaaggatcgc atcactcaca cgaacggtgt aatcgagctt 3303241 gcttttcttg gctttgaaga cggcccggaa acagaaattg aactgattca aggctacagc 3303301 agcgagcttc ccgctgaagg aaaagtgcac cacattgccc tgctgacgga tgacatcgcg 3303361 gctgaatata caaaagcgga aaaaatgaac gcaaaattta tcgacgagga gatcacaaca 3303421 cttccaaacg gataccgtta tttctatatc gaaggccctg acggtgagtg gattgagttc 3303481 tttcagcggt aaaaataaag aacgtacatt ttgtgatgta cgttcttttt tatctatacc 3303541 aactgatata cggctataca gccatgaaca gcataaaatg aacgttatta cagttatcac 3303601 cacatatggc gggattgtga ctgggcaggc aggcaagacc caatgatgca aagggagtat 3303661 taatgcctaa aaaacagggc attttaactc ttcttttcgt gttgggctca taacggcgcc 3303721 ttggacaacc ccctattctc atgctccgtc gtcgacgcgg gcatttttgt cattttcagc 3303781 cggtatttct cacttttttc attttgattg tcaacttttc atttgatacg atgaacaagc 3303841 cgacttttct tcagcaaagg aggttttaat tgcttgcata aagagattgc aaaagaatta 3303901 ctgctgctcg caggaggaaa aaacaatatt atcagcatca gccattgtac gacccgtctt 3303961 cgttttgatg taaaggacga gacgaaaatt gatatacatg ccattgagaa cctgcaaggt 3304021 gtgcagggca cctttttccg ctatgggctt ttccagatta tcttcggagc aggcgtcgtc 3304081 aacaaaatat ataaagaagt cgttcatgta tgggagaccg cgccttctga agagcctgtc 3304141 caccagaaaa aagccagccg gaagctgaac cctgccgcag cttttgcgaa aacactgtcc 3304201 gatatttttg tgccgattat tccggcaata acagcaagcg gcctgctcat ggggctgatc 3304261 ggcatgatta aggtgtttca ttggttcgct gccggcagcc catggattaa aatgctcgac 3304321 ctcgtgtcca gcacagcctt tattttactg ccgattttag tcggcttcag tgctgcacgg 3304381 caatttggca gcaacccata cctaggggca gtgattgcag ggcttttgac gcatcctgat 3304441 ctgctggacc cgtctatgct cggcagcaaa accccgtctt ctttagacat atgggggctt 3304501 catatcccaa tgatgggcta tcagggttcc atgataccga ttcttctttc cgtttttgtc 3304561 atgagcaaaa ttgagaagct attaaaatcg attgtgccga agtcgcttga tgtcgtgatc 3304621 attcccttta ttacggtcat ggtgacaggg tgcctcgcgc tgattgtgat gaatcccgcc 3304681 gcgtccatca tcggccagat catgacacaa tcgatcgtct atatttatga tcacgccggc 3304741 attgctgccg gagctctttt cggcggcatc tactccacca tcgtcctatc tggattgcat 3304801 catagctttt atgcaattga ggcaacgctg cttgctaatc cgcatgtcgg tgtcaacttt 3304861 ttagtgccga tatggtcgat ggcgaatgtg gcccaaggcg gagcggggct tgcggtattc 3304921 ctcaaaacga aacaatcaag cctgaagaaa attgcgctcc ccgcttctct gaccgcgttt 3304981 ttaggcattg ttgagccgat tgtattcggg gtaaatctca aattgatccg tccctttatc 3305041 ggagcagcca tcggcggtgc tattggcgga gcatacgtgg ttgcggtaca agttgtggca 3305101 aattcctacg gactgacagg cattccgatg atttcaatcg tgctgccgtt tggcgccgct 3305161 aattttgttc attatatgat cggtttcttg atcgcagccg tctctgcttt tatagctaca 3305221 ttgtttctcg ggtttaaaga agagacagaa taactggatt tattcgattt cattcataaa 3305281 acgggggatg aaaggacaaa aaagctatga aaattaaaag aatcttaaat cataatgcta 3305341 tcgtcgtaaa ggatcaaaat gaagagaaga ttctcttggg tgcaggaatt gcgtttaaca 3305401 aaaagaagaa tgatattgtc gatccgtcaa aaatagaaaa aacctttatc agaaaagata 3305461 cacctgacta taagcagttc gaagagattt tagaaacatt gcctgaagac cacattcaga 3305521 tttctgagca aattatctct catgccgaaa aagagctgaa catcaaaatc aacgagcgca 3305581 ttcatgtcgc tttttcagac catctttctt ttgcaattga acgcctgagc aatgggatgg 3305641 ttatcaaaaa tccgctgctg aatgaaatca aagtccttta tccaaaggag ttccagatcg 3305701 gcttatgggc cagagcactg attaaagata aactggggat tcacattcct gatgatgaaa 3305761 tcggcaatat cgccatgcat atccacacag caagaaacaa tgccggcgat atgacacaaa 3305821 cgcttgatat tacaacaatg atccgtgata ttatcgagat tatcgaaatt caactgtcta 3305881 ttaatatcgt tgaagatacc atctcttatg aaaggctcgt gacccatctc cgctttgcca 3305941 ttcagcatat caaagcaggc gaatccattt acgagctgga cgcagaaatg attgacatca 3306001 ttaaagagaa gtttaaggat gccttcctgt gtgccctaag catcggcacc tttgtgaaga 3306061 aggaatacgg ctttgagttt cctgaaaaag aattgtgcta catcgccatg catattcagc 3306121 ggttctacca acggtcagtc gcacgctgag acaaacaaaa aacgcttttg atcatctcaa 3306181 aagcgttttt ttatctgatt tattggttga tcgccggatt cccaatcgta ttccacttcg 3306241 tataggacat gtaatggaaa tactcatcgc gatacggatg ttttgtattg gagttccaag 3306301 gcttttctcc gccgcagaag tgcacgattg ccgggttttc tcttgtttca ttatattgct 3306361 tccgccctaa cagagtcgat ggggttttca gctttaacat gatataggtt tgagcgttcc 3306421 agcgcggatg aagttcatac cactgatcat acaagatcgc attcagtgca tcttggtcat 3306481 gcagcacaag aaagtcttcg tctgggtgtt cattgataaa gttgatgact ttttctgtga 3306541 tgttttgctt tctccaagac tcaaaatcaa taatcatgat acctgagtta aaatacttcc 3306601 ctgtatcagt gacgttcatt tctttcaggc gttcatgctg ccccgcatcc tcaacagcgg 3306661 ctacggtgta tggcgcaatg tctaagtccc atagcttaga aatatcctct aggacaagcg 3306721 catcacaatc gatgtaaatc attcgtttga tgctttcatc cttaattaag tcgggaatcg 3306781 aaatgcggta atacgcggct tttgtaatat ggctgctctc aaccgcatgt tcatacatgt 3306841 tggtatccac ttctaaaaac tcaatcggca ctccgaattt caaagtggtt tcttccagtc 3306901 tttttttgtt atcaggctta attccgccat caatgacgta taattttacc tctctctcct 3306961 gatccatgtt agtcaataaa gaaacgaaca tcccacctaa atgacgagca taattatcat 3307021 ctgcgcatga tacgatatgc atgatttcat ctttcctcaa tggtattcat ctcccttttt 3307081 gttgtacaag ttacataccc tttttcaaaa aaataaacac gttctccgac atttttttaa 3307141 acagaatgtg tgatacaaca aaaaaggtgt cattttttga agatgcgata aagccaataa 3307201 agaatgaaaa agcttgcgat tgtgatggct tcagccgaga cgatatacca cggccatggc 3307261 ccgagaacat ctaagagaga ggaaccgccc ggttttttcg tcaaatacat ataattcgcg 3307321 ccaagccagc gatcaatcag aaaaatacag acgccgtaca cattaacaag caggactgtc 3307381 acccataacg agcgctggcc cattctgtag gtgccaatca cagccatcag cagacaggat 3307441 aaaaacacag acccgtgaga aataaaaaag aggatatatc ggatatgcgg aaatgaaaac 3307501 ataccgaggt caggagtggc aagagcctga atcgaactgc cgatgccgac aaaaaacaaa 3307561 aacacaaaca gctttctgct ttttgtcact aacataatag ctgacaaata caccgacagg 3307621 tcactaagct ggagaggcaa tgaagtgcgc accgaccacc tgtccgtggc gaccatccat 3307681 atttgatagc cgatttgcga accaagcaaa agaaacacaa acagagaacg caaaaaccgg 3307741 ctggccctcg gctgcttgac ctcatcttgg aacaaaaaca acagaatggc caaaagggag 3307801 ataatcgcta acgtcactac atgctctgtc gaaaacagat gaaacggatc atgcttatag 3307861 tcggattgaa catatttttg caaaactgca cccccgtttt cgggtttttg tttattttgg 3307921 cgttgtttgg gcttttttta ttcaaccgat atatgggctt gaagttcaca ccagactctg 3307981 ttaaaattcg tttcatagct aatgattctg ataatttaag gcaggcctaa aaaatggaac 3308041 gttcacatca acatcagcag cttcggaagg aagaacacga tacactttct aagctcaaac 3308101 aaatgcccgt cgagtcactc aacctggaag ccatttcgat cgctacgaat ctgtatcggt 3308161 ctgcacaaag gctccgtgtc aaaatggaga ctgaggttct ttctacctat aacctttctt 3308221 ggaccgcttt ctccattctt tatgatctat gggtatgggg agcgctcgaa acgagaaaaa 3308281 tcgctgagct gtcagggata tctacagcta cagcaagcaa cgtgatcaaa acgctcgaaa 3308341 aaaagagttt ttgccgtaaa agcatcgaca caagagatcg gcgactcgtg tttgtctcaa 3308401 tcaccgattc cggcaaacaa gcgatcgaag aactctaccc ggagtttcac aaaggggaaa 3308461 cagagctcat tgcgggaatg acgaaggacg aacagaaaat attgacaggg ctgcttagaa 3308521 aggtagctga caatcttcat acaacataag ctttgacggg aatccagtag cggtttgtct 3308581 ccctgtttca gagagccggc ggtaggtgcg agccggcgca caggcaaacg tgaattacct 3308641 ccccaagctt tctttgtgaa ccttagtagc aaagaacggg aaaccgttat tcgaatgagc 3308701 ggaagacaat gtcttcaacc agggtggtac cgcgtgcatt gagccacgtc ccttattggg 3308761 atgggctctt ttttgtgttt gtaaaaaagg aggaaaaatg atgagaacat ttgagcagct 3308821 cacagcgtca caacaaaaag aggtagaaag acagcttcag ctatacatga caggcgccca 3308881 cgaagtcata ccgccggagg aattaaaggc aaagctcgtg aaatcaattt ccacgggcac 3308941 gccgcttaaa attaagctcg gattagatcc gtctgcaccg gatgtacatt tgggccatac 3309001 ggttgtgtta aataagcttc gccaatttca agaaaacggc cacattgtcc agctgttaat 3309061 tggggatttc acaggaaaaa ttggtgatcc gaccggaaaa tcggcagcca gaaagcaact 3309121 gactgatgaa gaagttcagc acaatgccaa aacctacttt gagcaattcg gaaaagtgct 3309181 tgatccagaa aaagtcgagc ttcactataa ctcaaaatgg ctgaaaacat tgaatctaga 3309241 agatgtcatt gaattagcag ggaaaataac ggtagcccgc ctgatggagc gcgacgactt 3309301 tgaagaacgc atcgccatgc aaaaaccaat ctcactgcat gaattctttt acccattgat 3309361 gcagggctat gattctgtcg ttctcgaaag tgatattgaa ttaggcggaa cggatcagca 3309421 tttcaatgtc ctcatgggac ggcatttcca agaacgatac aacaaagaaa aacaagtcgt 3309481 catccttatg ccgctcttgg aaggcttgga tggcgtcgag aaaatgtcga agtcgaaaca 3309541 caactacatt ggcattaacg aacatccaaa cgacatgtac ggaaaaacga tgtcactgcc 3309601 cgacagcctg atgaaaaagt acatccactt ggcgacagac ttagagcttg aagagaaaaa 3309661 acagctcgta aaagacttag aaaccggcgc cgttcatccg cgtgatgcca aaatgctttt 3309721 agccagaaca atcgtccgaa tgtatcacgg agagaaagca gcagaagctg ccgaacactc 3309781 gtttaaaaca gtctttcagg aaaacagcct gccggaagat ataccggccg taaactggaa 3309841 aggcgaaaaa acgatagcga tgattgatct gctcgtcaag ctaaagctcc tctcttcgaa 3309901 gagcgaggcg cgccgcatga ttcaaaacgg aggtgtacgc atcgacggag agaaagtaac 3309961 agatgttcac gccaaagcag agataagaga gaatatgatc atccaagtcg gcaaacgcaa 3310021 gtttttaaag ctccaataat ctgatattcc gaaacgctta tgacccttca ttcataagcg 3310081 tttttttgca ggtataaagc actgtctttt caaaaacgct ctccatcttg caggaaactc 3310141 ctttagcatc ccgaaatatt ccccaaccat acatttaggg gaggtttatt tttgatgaaa 3310201 aagcttttga ctgtcatgac gatggctgtt ttaactgccg gcacactgct cttgccggca 3310261 cagagtgtca cccctgccgc gcacgctgta caaatatcaa atagcgagcg cgagcttcca 3310321 ttcaaagcaa aacatgcgta ctctaccatt tctcagctaa gtgaagcaat cggccccaga 3310381 atagccggaa ctgcagctga aaaaaagagt gccctattga tcgcctcatc aatgagaaaa 3310441 ttaaagcttg atgtgaaggt tcaacgattc aacattcctg accggcttga gggtacactg 3310501 tcttcagcag gacgcgatat tcttctccaa gcggcgtcgg gctcagctcc gactgaggaa 3310561 caagggctga cggccccgct ttacaatgcg ggattgggct atcaaaagga ctttaccgct 3310621 gacgccaagg gcaaaatcgc cttgatttcc agaggagacc tgacttatta cgagaaagcc 3310681 aaaaatgccg aagccgccgg agcgaaagct gtcatcattt ataacaacaa agaaagcctc 3310741 gtgcctatga cgccaaacct gtcgggaaat aaagtcggca ttccggtcgt cggcattaag 3310801 aaagaagacg gcgaagcact tacccagcaa aaagaagcca ccttaaaact aaaagcattc 3310861 acaaaccaaa cctcccagaa tatcatcgga atcaaaaaac caaagaacat caaacatcca 3310921 gacattgtgt acgtgaccgc ccattacgac agtgttcctt tttcgcccgg agcaaatgac 3310981 aacggctcag gtacctctgt tatgctggag atggcgcgtg tcttaaaaag cgttccatct 3311041 gataaagaaa tccgctttat cgctttcggc gccgaagagc tcggcctgct cggctcctct 3311101 cactatgtag atcatctatc ggaaaaagag ctgaaacgaa gcgaagtgaa cttcaactta 3311161 gatatggtag gcacaagctg ggaaaaagcg tctgagctgt atgtcaacac attggatggc 3311221 caatctaact atgtttggga atccagccgt acggctgctg aaaaaattgg gtttgacagc 3311281 ctgtctctga cacagggagg atcatctgat catgtgccat tccacgaagc cggcattgat 3311341 tccgctaact ttatttgggg agacccggaa acagaagaag ttgagccgtg gtatcatacc 3311401 cctgaagact cgatcgaaca tatcagcaaa gaacgcctcc agcaagcagg cgatcttgtg 3311461 acagccgctg tctatgaggc tgtgaaaaaa gagaagaaac cgaaaaccat taagaaacaa 3311521 atgaaggcga aagcatctga catttttgaa gatatcaaat aaaaaaagac ggcacttggg 3311581 tgccgtcttt tttaatccac ttctttctta atccccagca ttttctcatc taggtaatgg 3311641 gcaatctccg cggcttcttt cagctcatct gttaattgct taggaacgtc attgttcaat 3311701 ttataataaa ttttatgttc aaggctcgcc cagaaatcca tcgcgattgt ccggatttga 3311761 atttctgctt tgacgtattc cacacggttc gttaaattca caggcatctc aatgattaaa 3311821 tgcaggcttc gatagccatt cggtttgggt gtctggatat aatcctttac ctttacgatt 3311881 ctcaaatctt catgctgctt caacacattc acgacattat aaatgtcaga aataaaggaa 3311941 cagatgatgc gcacgccggc aatgtcgtga atatgctcct tcatttcctt cgtcgtaatc 3312001 tcacagccct ttctcattaa cttattcacg atgctttcaa agctttttac acgggatttt 3312061 gtatgttcaa tcgggttgtg tccgtgaatg aggttatatt cctggctgat aattgagaac 3312121 tttgtatcga gcgcatctag cgcaaattta taaactaata actcattttt ccaatcttcc 3312181 attactgttt ttaaatcgtc catatgtgtt acagataaat ccatgttcgt catctccttt 3312241 aacggaactt tatccgctgt ccatgtacta gacgtccctg tctgctgcaa ggttctatga 3312301 atttttttac aaaatgcggt cgattgtaac aaaaaaagac cgcatgaaac gagcggtctt 3312361 ttttattatc ggaaatagct gatcaataat ccgatcgaga gcaggaatcc gaaaaatgta 3312421 tttgtttggg ctgttgattt cattgcgaca atcatattca tcggcatttc gttctggacg 3312481 aagcccttca ctgcctgaac cggcttaggc acgctcaaaa agacgacaaa cagccatggg 3312541 cttgcggcac cggtaataac caagccgaca acccagatat aagcgacggc aaacgacgca 3312601 gctaacagag taacagctcc cttatgcccc atcaaaatcg ccaatgtttt gcgtccgcct 3312661 tttttgtcct cttcaatatc acgaatgttg ttcgacaggt taatcgcgcc gacaagaatc 3312721 gcaatcggga tggaaatcaa aatgctctgc atattgatct tatctgtctg aatgaaaaac 3312781 gaaatcagca caaacaccga acccatgcaa atgcctgaga ataattcacc gaacggcgtg 3312841 tacgcaatcg gcagcggccc gcctgtatac aggtagccga tcgccatgcc gacaaggccg 3312901 atcagcgcaa gccaccagct gctgctggca caaatataga caccgagcaa aatggcaatc 3312961 ccgtatgagg caagagctaa ttgcaaaatc gttttaggct tcattccgtg gcgtacaatg 3313021 gcccctccga ttccgactga ttctgctgta tctaatccgc gtttaaaatc atagtattca 3313081 ttaaataagt tcgtcgcgat ctggatccat aggcaagaaa acagcatagc caaaaacagc 3313141 agcagatcaa ccttcacata aaacatcgcc aaaacggttc cgagcagcac aggcacaaac 3313201 gatgcggtta acgtatgagg acgggttaac tgccaaagga tctgccccat gctttctttt 3313261 tgcggcgctg tctgaccctc acccttattt gtttggttca tcttcctctt cctttctatt 3313321 aaaaggctta ctttttttca gccggcagct taataaaaaa ctccttttgc ttccttatct 3313381 atcataatga cttctccctt atttcacaag ataccgcaag aaggcgtttt ctttcttatt 3313441 atacgcttct cgccctgatt tcattaggtt tctgctttca cttgaacgaa caggtacaga 3313501 aaaatttttt taagtacatt acacttttta aaagttaaaa agatcttttg actccaggta 3313561 tcttttcctt tattatgaat cagctcgaaa cattccattc ttgcccttgc aggtataaag 3313621 attcattttc aaaaacatac gccgatatat taatttgagg gagattaggg aaaaaatgaa 3313681 actttttgag catctgatcg tcaaataatc atgtgattgt cgaaaaaacg ggaagggaat 3313741 ttttgatatg ctgcaattaa tgaaacagct gtatgaaaaa cccgctgtca agtggacatg 3313801 tcatacaggc ttttatttga tgatactgct tgttttgttt tttatgtatg gttttcacac 3313861 cgcgaatacc ggttcatata tttataacga tttctaattg gagagagaat aactatgaaa 3313921 cttttacatg ctattcaaac acatgcggaa acttatccgc aaaccgatgc cttccgctct 3313981 caaggccagt cgctcacgta tcaggaatta tgggagcagt ctgaccgcgc ggctgccgcg 3314041 atccaaaaac gcatttctgg ggaaaagaaa tctcctatcc ttgtgtacgg ccacatggag 3314101 ccgcacatga tcgtttcctt cttgggaagt gtcaaagcgg gacatcctta tattccggtt 3314161 gacctgtcta ttccgtccga acggattgcg aaaattatcg aaagctctgg agcagaattg 3314221 ctgatccatg cagcaggact ctcaattgat gcagtcggcc agcagattca gacagtttct 3314281 gcggaagaac tgctggaaaa cgaaggcggc tctgtcagcc aagatcaatg ggtcaaagaa 3314341 cacgaaacgt tttatatcat ttacacttcc gggagcacag gaaatccgaa aggcgtgcag 3314401 atttccgctg cgaaccttca aagcttcaca gactggattt gtgcagactt tccagtcagc 3314461 ggaggaaaaa tatttttaaa ccaagcgccg ttctcatttg atttgtctgt catggaccta 3314521 tatccgtgcc ttcaatcagg cgggacttta cattgcgtga caaaggatgc tgtgaataag 3314581 ccgaaagtct tatttgaaga gctgaagaag tccgggctga atgtgtggac atcaacacct 3314641 tcctttgtgc aaatgtgcct gatggatccg ggtttttcac aggatctgct gcctcatgcg 3314701 gacacattta tgttttgcgg agaggttctt ccggtttctg tggccaaagc gctgcttgag 3314761 cgttttccga aagcgaagat ttttaatacg tacggcccga ctgaagcgac agtggctgtc 3314821 acatcggttg aaattacgaa tgacgtcatc agccgcagcg aatcgcttcc agtgggcttc 3314881 gccaaaccag atatgaacat tttcattatg gatgaagagg gacagccgct tcctgaggga 3314941 gaaaaaggag aaatcgtcat tgcagggccg agtgtaagcc gaggctacct tggtgagcca 3315001 gagctgacgg aaaaagcgtt tttctctcat gaaggccagt gggcataccg aactggcgat 3315061 gccggcttta ttcaagacgg tcagattttc tgccaaggac gtttggattt tcagattaaa 3315121 cttcacggct atcgaatgga gctggaggaa atcgagttcc atgtcagaca gtcacagtac 3315181 gttcgttctg ctgtcgtgat tccttatcag ccaaacggaa cagttgagta tctgatcgct 3315241 gctattgtgc ctgaggagca tgagttcgag aaggaattcc agctgacaag cgctattaaa 3315301 aaagagcttg ccgcttctct tccggcatat atgatcccga gaaaatttat ctatcaggat 3315361 cacattcaaa tgacggctaa cggcaaaatt gaccgaaaac gcattggcga agaggttctt 3315421 gtatgacgcc ttacagctcg tttttattct ttatactgct tggcattctt cttctgccga 3315481 cgatcattct cggcttaaac ggaaaaagat ttcaagcata caacatgttc atatctatca 3315541 ttatattggc tttaattttt tcgcacgact tacacggggt catcgcgctg tgcctgttta 3315601 caatatggca ggtgctcctg atcagcggct atctggcata ccggcagaaa gcgaacagcg 3315661 gctttgtctt ttgcggagct gttatcgcgt ctattctgcc tttatttctg tcaaaaatat 3315721 ggccgtttct ttcacacccg cagccgcatc atccgccgca taacctgatc agctttttag 3315781 ggatttcata tttaaccttt aaaggcgttc agctgattat ggaagcaaga gacggactgc 3315841 tgaaagaaca gctgccattg caccgtctgc tgtatttcat cctgtttttc ccgacgattt 3315901 cctccggccc gatcgacaga taccgccggt tcgtcaagga tgaacagaag gcttggacga 3315961 aagaagaata cgccgacctg ctgtatacgg gaatccataa aatcttcatc ggtttcctgt 3316021 ataaatttat tatcggctac gcgatcaata cgtacttcat catgaatctt cccgcaatca 3316081 cgcacaataa gattcttggg aacctgctgt acatgtacgg ctacagcatg tatttattct 3316141 ttgatttcgc cggctacacg atgtttgccg tcggggtcag ctacattatg ggcattaaat 3316201 caccagaaaa ctttaataaa ccgtttatca gtaaaaatat taaagatttc tggaatcgct 3316261 ggcatatgtc tctgtcattt tggttcagag attatgtgtt tatgagattc gtattttgga 3316321 tgactaagaa aaagtggatc aaaaaccgta tggccgtctc aaacatcggg tatttcctgc 3316381 tgtttatgct gatgggggtt tggcacgggc tcgcgccgca atatatcatt tacggcctct 3316441 atcacgccgt tctgatgacg tgttacaact ttttcgagaa gtggaataag aaatataaat 3316501 ggctgccgtc caaccgctgg acaaccattc tcgctattgt gatcacattc catttcgttt 3316561 gcttcgggtt ttatattttc tcaggaaaac catttcatca ccaccattaa aggagattag 3316621 aaagctatgg attttaaaca agaggtatta gacgttttag cagaggtttg ccaggatgac 3316681 atcgtaaagg aaaatcctga tattgaaatt tttgaagaag gtttgcttga ttcttttgga 3316741 acagtagaat tgctgcttgc gattgaaaac cgttttgata ttttagtgcc gatcactgaa 3316801 tttgaccggg acgtttggaa tacacctaac aacattgtaa atcagctgtc tgagttgaaa 3316861 taatgaaaaa gcgttttttc ggtccaatta ttttggcgtt tattctattc gcaggcgcca 3316921 tcgcaattcc atcttcatgg ctgacaggct tcatcaccga taagcgtgtg aaagagtcag 3316981 caacagcctt gaatccgagt atgtttcaag ggctatattt acaagatcag atgctcaaag 3317041 atccgacata tcttccgatt tacgggtctt ctgagctttc tcggctggac gagttccacc 3317101 catctaatta ttttcaggta aacaatgagg gattcacgcc ataccttgtc ggcaaaggcg 3317161 gatcccagtc attgattcat tctttaaact tcgctgccca catggatcag ctgaagggca 3317221 aaaaaatcgt attcatcgtg tctccgcaat ggtttattaa gcgcgggtct gatgaacagc 3317281 atttcgcgcc gaactattct gcgctgcaag ggcttgattt ggcatttaac gatcagatcg 3317341 atcctgaaat taaaaagaaa atgatgaaac gcatgcttcg ctttaaggct gtgcaaaacg 3317401 atgccattct ttctgagctg tacaaagcaa tggtaaacgg tcagacgtgg aaagtgaacg 3317461 cgctgaagcc ggcggcgaaa gtgtattaca gcatgctgga aaagaaagat ctgtattatt 3317521 caacgacaga atcatccggg ccaaagcgct atatctcgca gtcagtaaag gataagtcat 3317581 ggtctgaatt gaataaacta gcggatcaat cgggcaaacg ccactccggt tctaacgatt 3317641 ttcacatcga caaccctgtc tataaaaagc tgaagccgaa agtgcctaag ctgaaaggga 3317701 aaaacaaagg aagatcgtat gcggtgtcac cggaatatgg cgactttgaa atgatgctcg 3317761 atatcctgaa ggatgcgggc gcagagccta tgtttgtcac cattcctgtt aacgggaaat 3317821 ggtacgatta cacgggcttc ccgaaaaaag gacgcactga ctattacaaa aaggtaaata 3317881 aacaaatcag agcgaagggc ttccaggttg ctgatttctc agggcatgaa tatgacccgt 3317941 atttcatgaa agacaccatt cacatcggct ggaaaggctg ggtgtatgtc gataaagcaa 3318001 ttgacgaatt ttataaaacc ggaaaagtca cttcatcctg agcatctcat aggacgcggc 3318061 tgcatatttc ctgctaagat ttgtaatagt aaaggaatca cagccaactt aattaagagg 3318121 tgttacatcc aatgaagatg acaaataata cggttttaat cacagggggt tctgctggca 3318181 tcgggcttga actggccaag cgcctgctgg aacttggcaa tgaagttatc atttgcggac 3318241 gcagcgaagc acgtcttgca gaagcgaagc agcagctccc aaacatccat acaaagcaat 3318301 gtgatgttgc agaccgttcg cagcgggaag cattgtatga atgggcttta aaggaatatc 3318361 cgaacttgaa tgttctcgtc aacaacgccg gcattcaaaa ggaaattgac tttaaaaaag 3318421 ggacagagga gctttttgtg gacggtgatg aaattgaact taatttccaa gcgcctgtcc 3318481 atttatccgc ccttttcaca cctcatttga tgaagcagcc cgaggcggca atcgttcagg 3318541 tcacatccgg gcttgcgttt aacccgttag ctgtttatcc ggtgtactgc gcaacaaaag 3318601 cggcacttca ctcgttctcg cttacgctca gacaccagct ccgcgacacg agcgtggaag 3318661 tgattgaaat ggcaccgcct atggtggaca cgggcttaaa ccaaaaatca cgcgataaac 3318721 aaggcctgac gtaccggggc atttcatctg aagaatatgt tcaatatttc ttggacggct 3318781 tgaaggaagg caaacaggag attacaaatg aacgtgttga aggtcttcgg gatgccactc 3318841 gcgccgatta tgacaggtta ttcgagcaaa tgaacacgca ggagaattaa tttctcctgc 3318901 ttttttcata tgaatttctt acaaatttga gcaaacctat tgcgattatt tgttgaaggt 3318961 atacaataga atataattat tttcaaataa gtttgataat ataaacaatt taacagcagg 3319021 gagattgacc atgactaaac aaacaattcg cgttgaattg acatcaacaa aaaaaccgaa 3319081 accagaccca aatcagcttt cgttcggaag agtgtttaca gaccacatgt ttgtaatgga 3319141 ctatgccgca gataaaggtt ggtacgatcc aagaatcatt ccttatcaac ccttatcaat 3319201 ggatccggct gcaatggtct atcactacgg ccaaaccgtg tttgaagggt taaaggctta 3319261 cgtgtcagag gatgaccatg ttctgctttt cagaccggaa aaaaatatgg aacgcctgaa 3319321 tcaatcaaac gaccgcctct gcatcccgca aattgatgaa gaacaggttc ttgaaggctt 3319381 aaagcagctt gtcgcaattg ataaagactg gattccaaat gcggagggca cgtcccttta 3319441 catccgtccg ttcatcatcg caaccgagcc tttccttggt gttgcggcat ctcatacgta 3319501 taagctcttg atcattcttt ctccggtcgg ctcttattac aaagaaggca ttaagccggt 3319561 caaaatcgct gttgaaagtg aatttgtccg tgcggtaaaa ggcggaacag gaaatgccaa 3319621 aaccgcagga aactatgctt caagcttaaa agcgcagcag gtagccgaag agaaaggatt 3319681 ttctcaagta ctctggctgg acggcattga gaagaaatac atcgaagaag tcggaagcat 3319741 gaacatcttc ttcaaaatca acggtgaaat cgtaacaccg atgctgaacg ggagcatcct 3319801 ggaaggcatt acgcgcaatt cagtcatcgc cttgcttaag cattggggcc ttcaagtttc 3319861 agaacgaaaa attgcgatcg atgaggtcat ccaagcccat aaagacggca tcctggaaga 3319921 agccttcgga acaggtacag cagctgttat ttccccagtc ggcgagctga tctggcagga 3319981 tgaaacactt tcgatcaaca acggtgaaac aggagaaatc gcaaaaaaac tatatgacac 3320041 gattacaggc attcaaaaag gcgctgtcgc agacgaattc ggatggacga ccgaagtcgc 3320101 agcgctgact gaaagcaagt aagaaaaaag ccggcccatt acaggccggc tttttttacg 3320161 cttcaatttt gttgaaaaac tgcggcagat acgctttgtg cgcctctagc atttcgtcta 3320221 aaatctgttt ggccacagta tcggacggga caagcgggtt aatcgtcatg gcaaggagcg 3320281 cagtttgata gtcacctgta actgccgctt ctgccgcgac acgttcaaag gatttgattt 3320341 gctggacaag gccgcggaca gacaccggca agtcgccgac agcaattggc ttagggccgg 3320401 ttttcgtcat cacacagttc acttcaactg cggaatcgtc tggaatactc gctattgcac 3320461 cattattgat cgtgttcacc ggctgaatgt catgtttatc attataaatg gagctgatta 3320521 agttacatgc tgcatcactg tagtaagctc cgccccgttt ttccagctgc ggcggtttga 3320581 tcgcaaggtt tggatcttta taaagctcga acagctcttt ttcgaccttc tgtacgactt 3320641 cagcgcgggt gccctccgtt tgtgatgctt ccagttcgtg ctccagcatc tcttttgttt 3320701 taaaatagta acggtgatag ccgcaaggga tgacattgag cgcttttaag aaatccggtt 3320761 cccattcggc gcctgagata tttttcatcg tcatcgcgtt tttcgggtcg cccatcgcct 3320821 cgatgacttg ctccttcaca cttacgccgt ccaagaaaac atccagcccg aataccatat 3320881 ggttcagtcc ggcaaattgg acttctacgc ggtccacatc tacatcaagc gctttggcta 3320941 cgcccatttt gatgccgatt ggaacattgc aaagaccgac gactttcttc aggttggagt 3321001 agcgaagcaa ggcttctgtt accatgccgg cagggtttgt gaagttaaca agccaagcgt 3321061 tcgggcaaag ctcttctatg tcctttgcga tctcaaggat gaccggaatt gtgcgcaatc 3321121 ctttaaacag acctcccggg ccgtttgttt cctggcctat cactccgtat tttagcggaa 3321181 tgcgctcatc ctttgctctt gcctgcaaaa gtccgacgcg gaattgggtc gtgacaaagt 3321241 ctgcgtcttt cagcgccttt ctccggtcga gcgtaagatg aatgtcaatc gggacgccag 3321301 ctttttcaac catccgtttg gcgagtgtgc cgacaatatt cagcttttct tcgccctcgg 3321361 ggatatcgac aagccataat tcacggacag gcagctcatc ataccgttta atgaacccct 3321421 ccactagctc gggcgtatag cttgaacctc cgccaatcgt tacaatcttc aatccttttg 3321481 tcatatgctt gctccccttt gctcggtgat tttttcatat aactcaatga tctctgcagc 3321541 catatccttc actgtcattg cattcattaa atgatcctgt gcatgaacca tcagaagcgt 3321601 catttccgtc ttttctccgc ccgcttcatt ttggatcagc tctgtctgat aatgatgggc 3321661 ttttgacaat tcttcagcag cgtcttgaag ctttttccgc gcttcttctg cgtcaccgct 3321721 tttcgcagcg gcaatggcct ccattgcgga gctcctaccg tttcctccgt gaaggatgat 3321781 ttgaaaaatg atttgttcca tttcctcatt cacgcgattc acttcctttc tctacagagc 3321841 cgcttctttg tcatctgttg ctgcaggcgt ttggaccagc tccagatcgt tttcttcttt 3321901 cagcttctgc ttatcccaca ttctgaagaa tggatagtag acaacaaagg acacggcaat 3321961 attaatggct tgcatgaccg cgcctgagac ttttcctcct gtcgccaagt agcctgaaaa 3322021 gatcggcggc atggtccacg gcactgcgat acccgccggt ttggcgacaa ggccggtgct 3322081 cattccgatg tacgtgagtg tcactgtgac aagcggcgtg atgataaacg gaagtaagag 3322141 cattgggttc atgacgatcg gcattccgaa tataatcggt tcgttaatat tgaagatggc 3322201 cgggccgacc gcaagcttcc cgagctgctt catttgtttg cttcgggcgc gcaggaacat 3322261 cgtgacaacc agtgccaatg tggcgccgct tccgccaata ttgacccaga tatcgaaaaa 3322321 ttgctgggtg aaaatcttag gaagctcctc accggcttgg aatgcgatcc ggttggcatc 3322381 cattgcgccg taccaaatcg gtgccatgac gccgccaaca atgtttgcac cgtgaaggcc 3322441 gcaggcccat aaaagcattt tgacggcttc ggcgacaagg cttcctccaa ggcttcctcc 3322501 cagaatggaa agcggagtcc ccaataaaac gcttacaata ttatgaaggc tttcaaacgg 3322561 tgtcgcttca acaatcagcc gggctgccca aattaggaag atgacggcaa agccggggat 3322621 taacgcgaca aatgacttgc ttaccgccgg cgggacaccg tccggcattt tgaagactaa 3322681 attgcgctgg ataataaggc ggtaaatctc tgtggacacc attgcgataa tcatggcgac 3322741 aaataagcct ttgcttccca tgagcgaaag cggaatcccg ccgccaacca tgatttcttt 3322801 cgtcgcgcca tccggcataa acggcacttg ataaggtgtt gctaataaaa atgccgcaag 3322861 ggaaatggct ccggccgaca aggcatcaac accgtatttc tcggcgagcc ggtaggcaat 3322921 gccgaacgcg gcgacaagac ccataatttc aaaggtcgcg tcgactgggt aggccagttt 3322981 ttcagaccag gagctgccaa acgtttttgc cataaactca gcgtatcccg ggatcgggag 3323041 gttgccaatg atgaggaaaa aggaaccgat gataatcagg ggcatcgtga ggatgatacc 3323101 atcacgcagc gcctgcaaat gacgctgtcc cgcaattctt cccgctatag gcatgacctt 3323161 ttcttctaag atctgattga ctttattcac atagcccgcc cctctctatg acacatgtcc 3323221 aagctgttca gctgatttca gcacttccgc cccattgcac gttccataat ggacggtatt 3323281 aatgacgtct accggaaccc cctttgactc tcctaatttt ttgagctgcg gaagcatgta 3323341 acggacttgc ggaccgagaa gcaatacatc cgctttatcg atatgatttt gtacagaatc 3323401 gcctgaaact gcccaaatgg tatagtcttt tccctgttcc tgcgcacttt tttccatctt 3323461 gctcaccagt aagctagtag acatgcctgc tgcacaaacg agtaatatat tcatgtaaaa 3323521 gaccccctag agtttgatca attttgtaat gtcctgctgt tgctatcatc atattatgaa 3323581 atcgctttca taaacactca gggtttttcc gcaggcaacg gaaaaaaggt atatacaggc 3323641 tgtcagctca gcattttttg gtcaaacaca tccgaaagct cttgatatga acggcatttg 3323701 atcagctggt tcatcgccgc cgggtcatcc aaaatgctgc caagcagttt atacatgctt 3323761 tgtaaatccg ctttgttctc cttttcgaca caaagcagac agacaaattg aactcgctga 3323821 ctctcccaat cgatcggttt tttgagcgta caaacggccc aaaacgttgt tttcgtctgc 3323881 ggaacaagcg ggtgcgggat ggcaacaaga ttgccaaaac acgttggcga catgtcttct 3323941 ctttcaaaaa tggaatctat gatttcttca tcggcaaagc cgcattcgac cactttctgc 3324001 cctaaaaatt gaatcacttc ttcttttgag cgcagatcct cctgaaaaaa aacgagttct 3324061 ttttttaggt agcgattggc tttttccttt tcatcactca gaatagattc tatttttgta 3324121 aagtcagttc cgcctaagat ggtgttaacc ttcagtactg gtacagggag ctctttttta 3324181 atcggaatgg tgctgatgac aaaatcaatt gattcgtagg acatttgatc aagactataa 3324241 tactcagccg ttccaagaat atcgagccgc ttgccgaaat gggaacgcag tttttcgcgc 3324301 agaagctggg cgcttccggc tcccgatgcg catacaatga tacagcgttt cggcgggctt 3324361 tctgtttttt ttcgttcaat cgcggcgcca aagtggagag ccaaatatcc aatttcgttt 3324421 tcatgaatct caatacccgt ttgttccttt atcacgattc cggcaatgat cccggcttca 3324481 aaagcgagtg gataatgttc cttgatcgct gccagcatcg gatttcgaag attcatgccg 3324541 tatcggttgc ggctgatcgc cggcttcata tgcagtgcca agccgatttt cagctctttg 3324601 tcatgcagga tgccaagctt cagttcacga tcaacagctt tgatcatggc aagtgtcagc 3324661 tgatcggttt cctcttctat tgaaaatgtg tcctctccgc attgtgattg tgtcattcgt 3324721 tttgtgccaa ggagatgcat ggtgatgtag gccgtctcgt ctttcggaaa cgtaacggaa 3324781 agctttgatt ccagctcttt tacgatggct tctgcagcct ggtactcctt ttgatgcagg 3324841 atatgatcca tatctttcgg gaaaagagaa acatagtttt ccgttctgat ccgtttacag 3324901 gcgatagcga tatggataat gaggttattc agtcccatgt tggacagagg gatgcggtcg 3324961 tttttcattt ttttcaagat ggcggaacgg atgatctcaa tttcttcttt tggcaaaata 3325021 tcagcctttt catttaaaac atctatctcc gtttctcttt catcaacaat gtactccgcc 3325081 atgcagtacc tcatctgcac ctcgtccccg cgcagcttga agccgtaatt cggacgtgtt 3325141 tccatgacga tgcggtaagg cagcagacgt ttctttactt cctttaaatc cgtttggagt 3325201 gtagattttg agataaatag ttcttcagca agttcatcga gcttgagata atggtccgcc 3325261 agcagcagac gtttcataag ataggccatt ctctcctccg gcaataccgg caggcccttt 3325321 ttttgctgaa attcatcttg cagcagtgtt ctgaatactt gctcgtcatc aatgcggagc 3325381 ttgtagccgg agcctcttac agattgtaca aaggcaccgt ggccgcttag cacaccttga 3325441 agttccttta tatcattgcg gactgtccgc gtcgttacgt ttaattgcgc ggcaaaaaac 3325501 gaacttgtca ccggggcttc agccgccatc agcaagcgca gaatatcacg tagtcgccca 3325561 tgaagcatga gaaaaacctc ctaactagta gatgcaggga ttcagtgaat aggcagaaag 3325621 gatgatgaag ggatgcgaaa tgtatataaa ttctataatg gagagaatgg caagtcaatg 3325681 aacatccgga ggactagagg gaaaactgac ctataaaaaa acagccggga tcagccggct 3325741 gttctagatg cggacatatt cttttgttta gacgccttgc ggtccttcat gatttttcga 3325801 acaatcgggt aaatgaccgg cgcccatttg ataacggttt tgatcatctt tttcaaagct 3325861 ccgattctcc cttctttttt ctcaaccatt cccctgattg cctcttcctt aaacatgcta 3325921 acgcgacacg tacctgtttc ccgtcaccca gaaacgccat ggataatcgc gtgcctcccc 3325981 gctgttgtca atgccgatgc gcgggccggt tgaaattgct tccggtgtgt acccgctttc 3326041 gatgtaaagc ggctgttccg tgatccagcg tccgtagtca ttcatcgtga cgccaagcgc 3326101 tttcgtcagc tttcctggtc cgtttgtcca ttccctcgga ctcctgcccg gccttctctc 3326161 ctccattaac agctggcctt catgcggctc aatcgccctg attaatactg cttgcgggac 3326221 atcctcttcc gccgcaacga cattcagcaa tgtatgggtg tgcatcacgt atgtatatac 3326281 ccgcccagct tctgcaaaca tgatctcagt ccgcttcgtc cggcggttgt taaagctgtg 3326341 ggccgctctg tctccagccc ccatataggc ctctgtttcc acaatatagc ctgacgctgt 3326401 gccttcgtct gtttctttta caagaaggca gcccagaagc gatggggcaa gctcaagagc 3326461 ggttttttga taaaacgtga tgggcagcgg atttttttct ctcgtcacga atcgacctct 3326521 ccttttaccg atttttgtac attgtaccat tcccgaagca gatcaaaaaa aacggctgtt 3326581 ttaaaatctt tccattcagg gaatattgtt accgttcaaa aaaggagggc caaccattga 3326641 aagatgatca tcaaaacaag cagcaccaat caaatgccca agggagcgag gaagcgtttt 3326701 ctcataagac atccgggaaa aacgagtcag aggatacctt aacgaatagg caggggcatc 3326761 ctgttactga caaccagaat gtgagaaccg tcgggaatag agggcctaca acacttgaga 3326821 actatgattt tctcgaaaag atcagccact tcgaccggga acgcatccca gagcgggttg 3326881 ttcatgccag gggagcaggt gcacatggat attttgaagc gtacggaagc ttcggagacg 3326941 aaccgatttc aacatacaca agggccaagc tctttcagga aaaaggcaag aaaacaccgg 3327001 catttgtccg tttttcaact gtgaatcatg gaaaacactc gcctgaaaca ttgagagacc 3327061 cgcgcggttt tgctgtaaag ctatatacag aagacggaaa ctgggatttg gtcggaaaca 3327121 acctgaaaat cttttttatc cgcgacccgc tgaaatttcc ggatcttgta cacgcatttc 3327181 agcctgatcc agtgacaaac atccaggatg gtgaacgtat cttcgatttc atttctcaat 3327241 ctcctgaagc gacacacatg atcaccttct tgttttcgcc ttggggcatt ccggccaact 3327301 accggcaaat gcagggttca ggcgtacatg cctataaatg ggtgaatgag gagggcaagg 3327361 ccgttctcgt gaaataccat tttgaaccga agcagggcat ccgcaacctg acacagaagg 3327421 aagcagaaga gattcaaggg aaaaacttta accatgccac acaggatcta tatgacgcga 3327481 ttgaaaatgg cgattatcca gagtgggaag tatatgctca aatcatgagc gatgatgagc 3327541 atcctgaact ggactttgat cctcttgatc caacaaaact gtggtataaa gacgatttcc 3327601 catggaaacc gatcggcaaa ttggttctga acaaaaatcc ggaaaactac catgcggaag 3327661 tggagcaagc ttcatttgga acgggagtgc ttgtcgacgg gcttgatttt tcagacgaca 3327721 aattgctcca ggggcgtacg tttgcctact ctgatacgca gcgctaccgt gtaggcgcaa 3327781 attacctgca gcttccgatc aactcgccga aaaagcatgt cgccaccaac caggaaggcg 3327841 ggcaaatgca atatcgggtc gatagagcag aaggacaaaa cccgcacgtc aactacgagc 3327901 catccattat gggcgggctg aaggaagcga agcaagacgg aaaagaccat acgccgcatg 3327961 tcgaaggtga tgtaaagcgt gaagcgattg acagaacaaa caacttcgga caggctggag 3328021 aaacgtaccg gagatttact gaatttgagc ggaacgaatt gattacgaat ttggtgaata 3328081 cgctttctac gtgccgaaaa gaaattcagg atcaaatgat tgagaatttc acaaaagctg 3328141 atcctgacta cggaaaacgc gtagcagaag ggctaaaaaa ggtctccgaa aacaacagca 3328201 acgggccgat cggcacaact gaaacggaac aggctgcaaa gcaggctgaa caggagagtc 3328261 atccgtctga tccgtattaa caacagcgaa cagggctttt ttagaagccc tgttttttta 3328321 tttttctatt gaaacgcttt caataattgt gttgtacttg gaaggaaagg ggtggagaga 3328381 tacgatggaa ttacagcagg acttgattcc tcagaaaaaa acaatcggcg ctttagatca 3328441 cgccgttttt ttatgcatgg tattttgttt ctggttttca ggctatattt acgttcctgt 3328501 attcagtctg tatttggagg atctgcactt ttcatatggc gcaatcggca tcattctcgg 3328561 cagctacggg gtcacgcaaa tccttctgcg attcccgctc ggccttttgt cagacatcct 3328621 gttttccttg cgcaagcaat tgttaattgc cgggttcggc ttttccgtcc tcagcagcct 3328681 gctttttctg atgtttgatt ctttcttctt cgtgctggcc gcccggcttt tcgcgggaat 3328741 cactgcttct acgtgggtga tggcgaccat tttatacgca cattatttca acaatggcaa 3328801 tgcatcaaaa gcaatgggca tcatgcagtt ttttaccgtc atgcctcagt ttgccagcat 3328861 tgtgttctgc gggctcgccg cagcccattt agggaggcag gttccttttt ggatggcgct 3328921 ggcagcttct gccgcaggtc tggtgatctg ctgctttatt caggatccgt ctgctcctcc 3328981 cgcaaaccgt ggcaccattc gtgtcaatca gtacatcaaa gatacattgc ggctgccaaa 3329041 gctgaagctt ttcaccatcc tgtctatgac ggcccatgcc gtattattta tcacagtgtt 3329101 tggttttacg ccgctttaca tgaatcagct cggaatgggc gacgcggagc tgctttgggt 3329161 gatgagcgcc tttttcctcc cacacgcagc cgccacatta agctttgtgt ttctgcgctt 3329221 tacaagccgt atcgcttact ccgtgatgct cattagtttc gctgtcaccg gggtctgttt 3329281 gctatatgtt ccttttttag ctgcattgtt cacggtttgc atcacacacg cctgtattgg 3329341 gctggcgctc ggcttcgttt ttcctctgct gctaagccat gtcgtcgaaa tcagttctgc 3329401 ccgtttaaaa atgtcagtga tggggtttta ccaatcattt tatgcgctag gcatcttcct 3329461 cgggcccctt cttgccggaa aaatcgcaca gcttatcggg cttgcgggag ttttttatgg 3329521 agccggttct ctggcatttg ccgccttttt tgtgatgctc gcgcaaaaac gtaacatgat 3329581 caattaatag ctttcatacc gccggaagcg ccacacagaa aacacggcca gaagcatgat 3329641 gcacagaatg gagaaagtga gtgaccatcc gaaaaaatct gcccgctctc catgaagaag 3329701 gatatgctcc gcctgcttgc aaatctcagc cggaagccac ttcgcaccat ctggaaatag 3329761 tgaaacagca aaggaaacgg ctgctgtgag cccgatcccg caagccgcag ctgctccgac 3329821 agaccggaat atcgtacttc cggcaaggcc ggcggtcaca ataaatatca cccaaagagc 3329881 gtaaaggcca aggcttgcgg caaagcggct gaatgatgcg tcctcaaaca gcagccggac 3329941 gtaatagtaa gcaagcccgt atccagctgc aaacgacata atgccgatca cgctttggat 3330001 gagccattta ctcacgatat aatgggctgc cgtcacaggc cgcgacataa tcagcgctgt 3330061 taccccttga tttctttcat tggctacact gcccatcacg ctaaagatga ccagagccat 3330121 gccaagcgtg ttgaattgag aaagcgtgct gaccatcact tcagacccgg agggcatcgt 3330181 aaaactgatt ttcatgccgt caggaaggtt ccctccatgt gcgatgattt ccggcatata 3330241 ataaatggtc agcggctgtg tcagcccgac gatcatcatc gcaatcggca gccaaatcag 3330301 cttgccgctt ttccatcctt ccagccactc cttctgcaat agcgccatca tcaccttcat 3330361 gcgtgcacca cctttagata gacgtcttct agagactccg ttttctgttc aaagcgggtg 3330421 acggtcaatc cctttcggat acagtcactt aataatgacc ggccagcgtg tatatcaggc 3330481 agctcgaaaa ccgcttggga cggattctta tagacaatag ctgagacgta aggcttctct 3330541 tcaagccaac cttccagctt ctctttcact gaaagggtaa aaacgttcgt ttgctgctgt 3330601 tgtttcagct cctgtaactc gcctttccat gaaatctcac cgtttttcat aatcaccact 3330661 tgatcacaca cctgttctgc atcgtgcaaa acatgtgtag aaaacagaac ggccatatgc 3330721 tttttcagct cccgcatcat gtccagcacc tcgaaccgtc ctgtcggatc aagcgcagac 3330781 accggttcat ccaatatcaa aaacttcggt ttatggagca gtgcctgtgc cagaccgagt 3330841 ctttgtttca tgcctcctga atagcccccg atccttttgt gcgccgcttc gtgcaaaccg 3330901 acaaattcca gcatctcgcc gattttctct tggcattttc tcttcgaaag gccggacagt 3330961 ctccccgcaa atgtcaaaaa ttcatttgcg gtcatccacg aataaaaagc aggatactgc 3331021 gggaggtacc caatcaaacg ccgatccagc tttttctctc ctaacagctt tatggttcca 3331081 gaggttggcg aaagcagtcc ggccagcatt tgcagagtcg tggttttgcc ggctccatta 3331141 ggtcctaata gtgcgacaca ctcattttca ttcacgtgaa aactgacatt ctttacagct 3331201 tcatggtgcc tgtacgattt gcataatgat tcaatagaca gcatatcggc ttacctttgc 3331261 tttctgccga cggtgaaaaa taaaatcggc ccgataatat tgatacatac gatgattgca 3331321 gcccacatcc actttggccc gttcgtccgc tcttctttta tacagctgat aagggcaaac 3331381 accgccaaag ccagctgtaa tacaatcagc ggcaaaatca tttcccaaga aatattcatt 3331441 gcttgatccc ccttttcttc cgatccggcc taatgacaaa aaagtaataa caaatcagag 3331501 gcatcggtgc ttgaatcaat ccgacaatcc cccaaaccca tgccatgtga ttacgttttt 3331561 tcgcatcaat aaataaaaag attccctgcg ccaatacgat gagacaagcc gcaaccgtta 3331621 tgataatttc tgtttgtgtc atccgcgttt cacctcgcat tcgccgagat gccttttttt 3331681 ctcagccgca atcaaaatcg gcagcaccgc aagcacacaa acctgaagca caataaacac 3331741 agcaggagct tgagtgaaag ctaagattgc agcactcaca accatcagcg cgcagaatac 3331801 aaataaaatg atctcttgaa gaagtttttt tctgtattca gctttcattt gtgacagctg 3331861 gtgaagcagt tctttttgat tcggtataga gggattggct gtttgatcaa tttttttcca 3331921 ttctgacttt aaatgatcag aaagcttttc tttattcatc atcccactcc tttctgattt 3331981 gctggagccc tttatgaact ctggacttta cagtgccttc tttgatttga agcatcaccc 3332041 cgatttcagc gtaggtatag ccgtagtaat gccttaataa aaccggtgtg cgcagtttag 3332101 ggtccagctt tgaaaacaga tcgagcgttt cgctccactc tgcccctttc gccgacacgt 3332161 cccacttgat cttgcggatt gtttcctccg taactgtctg attccgtttc cattctctct 3332221 ttctcttttt ctggtgatcg agatagagcc gcgatgcaat ggagatcagc catgtggaga 3332281 attttgaacg gccctgaaag cttcttaaat ggatgtaccc tttcagaaag gtttcctgaa 3332341 caagttcctc gctgagatcg gggtgaaggg aaagctttaa caagtattta tataagaaag 3332401 aatagtgata gtggaaaagg gctgtaaacg cctcgtcgtt tccctctttc gcctgctgga 3332461 tcagccgctg ttcttcttgt gtatccaatg accgtgatcc cccctttttt gtttttctgc 3332521 cttatgagac gacaccggat tcaaaagcgt tcatcttttt tacaattctt ttcagccatt 3332581 gacagatcag gcttcccggc cgtttggctg catatcctta tttgtaaacc cccttatagt 3332641 ctgttaagct atgactttat gtcgatttca aaaaaacatc caatatggag gacgatgcat 3332701 tgaaagtaga aaggcgaacg attgaatata ttccgaatga agaaagacat ggtaaagcga 3332761 aagatttatt tcccgtatgg ttcggggcta atatgcatat caccacgtta gtgaccggca 3332821 cgattcccgt tgcaatggga cttaatctgt tttggagtgt tgccgctatt atttgcggaa 3332881 ccttaatcgg tgccatattt atggcttctc attccgcgca aggccctcag ctaggcatcc 3332941 cgcaaatgat tcaaagccgt gcccaattcg gcgtaatcgg agcgattctt cccctcttct 3333001 tagtcatgtt tatctacctt ggtttcttcg caagcagcac gattctggcg gccggaacct 3333061 taagcagctt tgttcccatc ccgggatcat ggagcattat aggcttaagt gccgtatgtt 3333121 ttttactcac cattttcggc catgatttga ttcacaaaat gcaaaaaatc ctttcttgga 3333181 cctcttttgc tgtatttttt gctgcaacga ttctcatttt tcaattgccg attccggcag 3333241 gcagctggat acccggagcg attgatctgc caattttcct agtggcagtc agcgcagttg 3333301 cgacgtggca gcttgcctac gcgccgtatg ttgccgatta ttcaagatat ctgccagtta 3333361 aaacaccggc ttcaaaaaca ttttggtaca gctatgcagg tacatctgtc agctccatct 3333421 ggatgatgct gctcggcgca ttgctgacaa cctcacttcc tgactttacg gcaaactcag 3333481 gcagccagat tgtccaattg ttcggtccct tctcgtttat tatgctgatc attgtgctat 3333541 ttgggcaaat ggcaatcaat gtttttaacc tgtatggggc tttcatgtcc acgacaacaa 3333601 cgctggagcc gtttctgaaa ttaaaagtca cgcccaaagt cagaatcatc atgatcctgg 3333661 gtgtcacgct tgtcggcaca gtcttaagcc tactgggaca gagcaatttt atggaactgt 3333721 ttttgaattt tatctttttc atcagttatt tcttaattcc gtggacggca atcaatttag 3333781 tcgattacta cttcgtccgc cacggaaagt atcaagtcaa agccatgttc gacgtaaacg 3333841 ggccttatgg aaaggtcaat tggatcacca caattgcgtt cgttctgtct atcttgctgg 3333901 aaattccgtt tatcaacaca agcttttaca tcggaccgct tgccaaaatg tttggcggcg 3333961 gagacatcgc atggattatc ggcttggccg tgccttctgt gctttactat gtattaatga 3334021 aaccgcgtct gaaaaaacgg gcggggtatc aagaaaagct gtcttctctc tgaagacagc 3334081 ttttttatca ttcaaatcgt ttccacacgc ggggcaggat gtcagatagc tcatgagcga 3334141 gcaacgtatg agcggagtgc tcgtccgtcc agagctcggc gcacgcacca tgcaaataga 3334201 ccgcgtttaa tacggcgtgc tttggatctt catggcagca gagcatcccc aatatcatgc 3334261 ccgtcagcgt gtcaccggtt ccgcccttgg cgagcgcccc gtttccggtt ggattgagcc 3334321 agcagtctcc atcaggaaac gcgatgacgg tttggtttcc ttttaacaca atgacagtct 3334381 gcagctgagc cgcccattcc tttgcatatt ccgctctttt tttctgcaat tcgttcacgg 3334441 gcacccctgt cattcggaaa aactcgcccg ggtgcggcgt gaggatgacg gggccctccc 3334501 gtttcggata tgtgcgcttc gccagcgctc cggcatccaa aataacagga caatcagccg 3334561 taagcacatg atcgactgcc tgctgtacgc tttccgtttg cggaaggccc ggtccgatgg 3334621 caatggcccg gtacgtctct tcaagctgag catccgccgc ctttttccag ccgtcacgcc 3334681 aataggtcgc ctcgggcaaa acaggaacaa ttagcgggat tacgttttct gatgtaccga 3334741 tgacaagctt gccgagaccg ctccgcatgg ccccaagccc tgcaagcagc gctgctcccg 3334801 gcatgtcgtc acttccagcc agcagcaaag ccgtaccgta cgtgccttta tggctctccg 3334861 catctctttc aggaagcgtg gcccttacat gctcttccgt ccaaaatgga acattcatct 3334921 ctatccctcc tctgctttct tttcctattt ttcctgtccc ttttcttttt caaacaaaaa 3334981 agacagcctt ttagggctgt cttttatttt acaggaacat caaggtgata caggcggcga 3335041 tatcgttcgt ttgccgccag cagctcctca tgggttcctt ccatttctgt tttgccgttt 3335101 tcgagaaata cgattttatc ggctgcttcc actcccgcga gatggtgtgt aatccataaa 3335161 atcgtttttc ctttcagcac ctcaaacacc gtttccatca attcacgttc ggtaatagga 3335221 tcgaggccga ctgttggctc atcgaggatg atgatcggtg tatcctgcag caaaatcctc 3335281 gcaagtgcga tccgctggcg ctctccaccg gaaaaacgga tgccggtttc ttgtacagag 3335341 gtatgatatc cgtcaggcaa tgactcaatg tagtcatgca gcttgacctg ctttgcggcg 3335401 cggcgcacat cctcgtcgct tgcttctccg tttccgagcc tgatgttgtt caaaatgctt 3335461 gtatcaaaca ggtgcggttt ttgatttaac acggccaccg catccgcaat ctgatccttt 3335521 aacagcgctg tctccactcc gtttaacgtc acagaaccgg agtccggttt caaggcgcct 3335581 tcgattaatg caagcgatgt tgatttccca gagccgcttc ggccgagcag cgccattttt 3335641 tctccttggc gcagcgtaaa ggaaaagttg tgcagcactt ggctgctgtt gtcataagaa 3335701 aacgtcacat cacgaaaggc caaggtgaca tcttgaagat cgagaatttg atcccctgat 3335761 tcagtttgtg acgcctccgg ctgaggagcc acattgttca tgcgtctgat agaatcctga 3335821 tagcccggca cttcgcctaa ggcatccgaa agcggcaaaa aggcttccgt caacggaaac 3335881 accactagca caaaagcggc aatcatcgtt ttagcgagct cgccgtccgc ttgctgtccc 3335941 gctgtccaaa acagcatcag caaaataagg ccagcgacaa ggcattgcgc agcaaagtcc 3336001 cgccatcttg taaagcgttg ttttttccgt tcaagctcaa accaatcacg ttcctctttt 3336061 tcataagcat caataaaagc atgccggcgt ccgctgaaca tccagtcgct gacacccatc 3336121 acagcatctg tcagacggct gtacagcaca ttccgtccgc ttttcagctt cgcattcttc 3336181 gctctcgtca cgagcaaaga cacaaccgga aacaatacaa caagaacaaa caaatacagc 3336241 gcaagcaata tggcaaacgg ccaagagaag aagccgagcg ctatcactga cacagcatac 3336301 aggagcaagg ctgagatcgc aggaaaaatc gtttttaaga aagcatcctg caaatgctca 3336361 atatcctcag acaaaatgcc gagcatatcc cccgtgcgaa aacgggaacg cagcatcaaa 3336421 gcacccggct caagcatatt gtaaaggcgg acgcgcatgt cagatacgat tttcaaaatg 3336481 atgtgatggc cgacgagccg ttccacatat cgcgacacag agcgcgcaat cccaaaggtg 3336541 cgcacagcga caatcggcac ataaatgagc agaatgtttt ccggccttgt cgccgcttta 3336601 gaaatcaaaa aacctgaggt gaacatgaga aaagcagcag aaaaaatcgt caccgcaccc 3336661 aaaaagataa ccagaacgaa caggcgggca ttttgcttga tatacggcaa aatccattct 3336721 tctttcttca tgctctttcc cccagttgtg ccttcacgag tttggtatac acaccgtttt 3336781 tctccagcag ttcattgtga gtcccaattt ccgcaaccct gcccccgtca agcacgataa 3336841 tttcgtccat atcgagcatc cagtgaaggc ggtgagtcgc gagaaagacg agcttatcct 3336901 caaataaatc cagcatcgtt tcttttattt catattctgt ttcgatatca agatgggcgg 3336961 tcggctcatc cagcagcagg atcggacggt ttcccaaaaa ggcgcgggcc agcgcgacac 3337021 gctgtgcctg gccgccgctg agcgcccggc cgccttcccc gatccgcccc tctaatccgt 3337081 caggaaggtt gttcaccagc tccgtcagtc ccgctgaggc agcagcacgt gttgtatcct 3337141 ctgccgaagc gcttggatgg tagaagcgaa tgttgttgcc aagcgtatca tcaaaaatgt 3337201 acggatgctg gggaatgtaa agaaggttct tctgccagct gccgtcctgc aaatgggacc 3337261 ggcttgtacc attaacctca atcatcccgc catccggctc taaaaatccg ccgagaatat 3337321 caattaatgt tgattttccg gcgccgcttg caccgataat gccgattttt ttcttgcctt 3337381 tgaatgagag atgaatatca gacaccgaac ggccgactga cacgcctgac agcttcagct 3337441 catcctgatc ggaccaagct tcgagctgaa gcggcgtctc ttctttaaaa ccaggctgcg 3337501 acaaaatctc ttgaatggtt tttcctgctt cctggccgtt cagcgttgca tgataatcat 3337561 tccccacttc ccgcaccggc aaaaaatact caggcgccag aataagcgcc gttaaagcag 3337621 ggccaagcaa aatatcgccg tcaatgaggc gcaggcccag aaatactgcg actgtcgcca 3337681 ccgacagcat cgtgaaaaaa tcgagggcga atgatgacaa aaacgccacc cggagtgtgc 3337741 tcatcgttgc cttgcgatac cgctcactca catagaaaat atttttgctg tgtgacttgc 3337801 tcaaacctag gaaacgcaat gtctccagcc cgcgaagaga atcaacaaaa tgattggaaa 3337861 gtctctgata ggatttccac tgacgatccg cttttctctg cgcgacaagg ccgaggagaa 3337921 tcataaagat gatcagaatc ggcatagcag cgactaaaat gatggctgat gtccgatcct 3337981 gaaaaaacac ataaatgaca actgccgcag gcacaatcgc catgctgacc attttcggca 3338041 gaaacagctc caggtagcgg cggaactggc tgatgccttc catcgccagc gtcaccattt 3338101 gccccgtccc ctctttcttt gcaaagcggg ggcctaatcg gaacagctga tcaagaaaac 3338161 ttttcctcaa atctgctcct gtccgggcgg cgtattgata gacgattttc tgtcgcgcca 3338221 ccgtcatccc gtgccgggcg ataaaagcga tgaggaaaaa gccgatcacc ggtaaaaggg 3338281 aggtaatgcc cttcccgttg aacagtccgg ttacggcctc actcagccac tctgcctgca 3338341 taataatggc ggctgtctga atcaacgtta aacaagtaat caaggtgaga atccgcttca 3338401 ttcctttata tcgaaacagg tcttttccca ttaataagtc ataggctcct tatggctgac 3338461 gcgcttccgg aagacataat agctccagat ctggctgccg atgacgaacg gcaatagcgt 3338521 taatgctgca attgacatga ctttaagcga ataatctcca gaagaagcgt tagctactgt 3338581 taaatcgtat gcgctatgaa gcgagctgac cattacacga gggaataggg aaataaagat 3338641 cattcccacg gtcagcgcca gaccagcgcc tgtcatccca aatgtccagc cgtctttttt 3338701 cttacgaata aatacagccg cgagcataaa gcagatgaca atcaaaacag cgagcggaat 3338761 ggtaatctcg ccgcggcgtg taaacatgtc tgtctgatac gcagaaaggg ccgcgaaggc 3338821 aagaaccgct acaaaaacaa cacccattat cttttgcgcc attttccggg cgcggttttg 3338881 caaatcacca atcgtacgca gcgtgataaa cattaatcca tgctggaagc aaagaagcgt 3338941 taccgtcaca ccgccaagta tagaatatac attgatataa tcagatacat gtgcgtgaat 3339001 gttcatgtcg gcatcaatcg gcatcccgcg gaataatgtc gtgaacagca caccaagcac 3339061 aaacggagga attagactgc cgaaaaaaac gacccagtcc caaaccttta cccattttaa 3339121 atgatccacc ttgccgcgga actcaaacgc gaccccgcgg cccattaacg caagcagcac 3339181 tatgacaaac ggaatgtaat aaccgctcag catcgttgca taccagtttg ggaatgccgc 3339241 gaaaatggcg cctgcgccag tcaaaagcca cacttcattc gcgtcccaga acggcccgat 3339301 cgtgttgatc agcactctgc gttctaattc attatggcca agaaaacggg tcgccatgcc 3339361 gaccccgaaa tcaaagcctt ccaaaaagaa gaatcctaca aacaatacag caacgagtat 3339421 aaaccaaaga tcatgaagag atgccatggt atacctcctg actaaatgga tctgttgata 3339481 caggcacatc atgatgatta tcatgctccg cacctttttt aatctcacgg ataaacaaga 3339541 agacaagcag tgcaccaaga atcatgtaca tcacaccgaa tgcgatgatt gagaataaca 3339601 aggaacccgc tgttacgtta ggcgacacag attgagcggt tgtcattaac cccataaccg 3339661 tccaaggctg acgtccgatt tctgtcataa tccagcccgc ggagtttgca agaaacggga 3339721 aggaaatcaa cgcgatcatg atgcgcaaat accatttgct gttttcaagc tttttacggc 3339781 ggtttaacca aaggccgcct aacgcagcaa gaatcatgac aacacctgct cctaccatga 3339841 tgcggaagct ccagaatgtc gttttcactg gcggaatgta gtcgcctttt ccgtatattt 3339901 tttcgtactc agcctgaagg gttttcatcc ctttgacact tccgctgaat ttctgataag 3339961 ccaagtagct caaggcataa ggaactttga tttcatttga gcttttttca ttttttgtat 3340021 cgatcgtcgc aaaagcggtc caagcagcag ggtcaccgct gtcttcccat aggccttcac 3340081 tggcagccat tttcatcggc tgtgattcca tcaagtgctc agcctgcatg tgtccgctaa 3340141 ggccgacgcc aagaccggca caaagaccga cgatcattgc gagtttaaaa gattgcttaa 3340201 agaacggcac ttcttttttc ttcagcagtt taaaagcact cactccggca ataaagaaag 3340261 ctccagtggc aagcgcaccg aaaataacgt gcgggaattc aacccaaagc tgagggtttg 3340321 taatcaacgc gccaaaatca ttcatttccg cgcggccgtt tttgatcgta aagccgaccg 3340381 gctcctgcat aaaggagttt gctgttaaaa tccagaaaga tgacatgatc gttccgaatg 3340441 atacgagcca tatgcagagc gcgtgaattt tcttcggcag gcggtcccag ccaaaaatcc 3340501 ataatccgat aaaaatagat tccatgaaaa acgccaataa tgcttcaatc gcaagcggag 3340561 cgccaaatac atctccgaca aaacgggagt aatctgacca gttcagtcca aactggaatt 3340621 cttgcaaaat ccccgttaca acaccgactg cgaaatttat taagaataag tgtccccaaa 3340681 actttgccat tttgagatac agctcatttt tctttacaag ataaagagtc tccatcaacg 3340741 caaccataaa cacaagcccg atagacatcg gcacaaacaa gaagtgaaac aacgttgttg 3340801 atgcaaattg tatgcgggct aataccaatt cactcatgct ttctcctcca tttccggtta 3340861 aaactgttaa tttgctcact acttcacaaa tagaaccgag actttgatca gtaattcaca 3340921 aaatagacga aaaaaatatt gctcaatatt tcacaaatgt gtcaaaaagt catccaatat 3340981 gatgcaagat tgccagactg accaaatgac acaatctctg actggttcat attaagtact 3341041 ttacaacgat tcatttcaaa aataaagcct aaaataccta aaaagtcccg cactatgtga 3341101 cggatttttg tctattttgt tgcttattta tgtcggctgc taggataaat gaccctttat 3341161 tatcgtacat caacacatcg ttccttgcga acaaaatgct tgcccccgcc ccagcactcg 3341221 agtctcagca ttccgtctta aaccgatttt agtcagaatg cctcttttca tttgaaccgg 3341281 taagaggaga aaagttgaat agtaaatttt taatatatta ataatttcaa ttttttagta 3341341 tacttaacat agtgaacaat ttcactgcat caagaatagg ggaggttttt caatgggaga 3341401 gcttcaaaca cacatgcaat tgcaaacgga tacaattcac gaaggggttc gaaaagagaa 3341461 ttggtttgcg aaagccatga atataaaagt aggcatcata ccgcttcctg tgtatgcctt 3341521 gctgtttata ttaatcactg tttttgttat gcatcacgat gtaaaaagtg acattttgac 3341581 atccattgcc gtcatggcgt ttttcgggtt tacctttgcc caaatcggca aatcgatacc 3341641 gattgttcgt tctatcggcg gcccggccat cctagctact tttattccgt ccgctgtcgt 3341701 gtactatcac ctgctgccta atgatatcgt caaatccacc acagaattta cagaaaactc 3341761 aaactttcta tatttgttta tcgccggtat tgtcgtcgga agcattctcg gcatgaaaag 3341821 agaaacactc gtaaaagcat tcatgaaaat ctttattccg cttattgtcg gttctgtcac 3341881 agccgctatt gtcggactgg ctgtcgggac attgctcgga ctcggatttc agcataccct 3341941 gctgtacatt gtcattccga tcatggctgg aggagtcgga gaaggcgcta tcccgctgtc 3342001 catcggatat tctgacatca tgcccatttc tcaaggggaa gcgtttgcac ttgttctgcc 3342061 atcgattatg ctgggcagct tgtgcgcgat tattctagcg ggattgctga accgaatcgg 3342121 aaagaaaaaa ccggaatgga caggcaacgg caaagtggac cgctccgaag aagagtcccc 3342181 tgcgctggag gaatctcaaa gcggacagca aatgttcaac ctttctttat ttgcgtcagg 3342241 cggtatcctt gctgtttctt tatacttagt cggcatgctc gctcacgatt ttttcggttt 3342301 tccggcaccc gttgccatgc tgttactggc tgttctaatc aagctgttca gattggtgcc 3342361 tgcctcaatt gaaaatggcg cgtttggagt gtcccgcttc ttttcaacag ctgtgaccta 3342421 cccgcttctc tttgcgattg gggtatccat gacgccgtgg gacaagcttg tcgccgcttt 3342481 taacctcagc aatattatca cgattctgtc tgtcgttgtg accatgatgg ccgttggctt 3342541 cttcactgga aaatggctga acatgtatcc gattgaaacc gccattatta atgcatgcca 3342601 ttctgggcaa ggcggcacgg gtgacgttgc cattttaagc gccgctgaaa ggcttgagct 3342661 aatgcctttc gcccaggtgt ctacccgcat cgggggcgcg attacagtat ccttaacctt 3342721 attgctgctg caccagtttt attgatcccc gcaagcaagt tcttcgtcaa acgaaagagc 3342781 ttgctttttt gcatgtccat gtttttgcaa gttcccatcc catgctatag taatagttgg 3342841 aaatactaga tagaaaggaa tctggcatgc ctatgggaac tcatctattt ctctttatgc 3342901 ttctcgggct gggattttat ttgatatcag ccctagctgc aaaactcatt ccggccatag 3342961 acttctggat tgatattgtt ctatgggtcg gcgctgcggc ttacatcttc tctcatctct 3343021 cattcatgga cggcattgtc tcactcgcga caatgttcta ctgctattgg accgcaatgg 3343081 atctcattgt ttcagagcgt gtggaaaaac cttcgggaga ctggcaggaa atcgagcttg 3343141 ccaaaaacaa aacacgcctc ctgtcagaca ttacgctgac cgccattgtg tttgcagggg 3343201 ctgtcatttt tttcatctat ggacctgaca caagccctct caaatatgtg atccttctcg 3343261 gaatgatctc cggcggaggg gcacttgtga agcgaatact gaatgttttt agcgtaaagg 3343321 ttttttattc agcagcctta gaaaaattgc atatcagctc acactatgaa acccgtacat 3343381 acccgctttc cgatttgaag aacattcagc ttgaatcaac agcagatctc ttaaagctcc 3343441 atccgcttct gacgatgtat tcatcccgtt tagatttgac aacaagcttt cagcaagtca 3343501 ttaaactgtc tcttcccggc gaaacactgt ttctgacggt gaaggaaccg caaaaatgga 3343561 aaacaattct tcaggaatac acagatgcag aaaacaatgt ggacaatgtg atttctgttt 3343621 tgccgtttta tcatcgaaaa aatgtgaagc ggctgctcgg taagctttat tttgccgcca 3343681 gcgtaaaagg ggtatccgct tacgccttat tggtgctcgc gttatacgca ttacacgcct 3343741 ctccatgggt catggctgtt gccgtaatcc tatattgggt attcaacatg tatatgtcag 3343801 accgtgtgtt gcgggcggcg atggacgcca agtcttgtca tcatccgcat gtacaggccg 3343861 cggccgataa gattttcaga tcggccggca tttcccatgt ccgcatatac gaaacggaga 3343921 gtgatgatta caacggaatg gcagtaggca tgaatgtcgg gaggtcaatg gtcatcctga 3343981 caagcgccac actaacactt ccacagcgtg tcattgaagg cattctggcc catgaggcga 3344041 ttcatatcaa aaaacgtgac gttctgtcat cacagctttt gcgttttcta tatcttggag 3344101 ctgtcgtggg gattttcctc ttgtttgagc agcatatcac ccatcccgag gcccacaaaa 3344161 ttgcgctttg ggctttcatt atggcaatca ttatcctatt ccagctctat caatcctttt 3344221 gttcacaatg gatggaggtg cgtgctgaca accttggcgc atcattgctg gacggcggtt 3344281 acaaacaaat ggctgaagcc ttgagaatct tggcggttcg gcaagatgag gatatacaga 3344341 aacaaagtgc ctatagctct gaagcaggtg aagacgagct tcaaattgat tctctcaccc 3344401 gtgataaaag ctggtttttc agattgattg attttcagtt cgctcctcat cctcctatgt 3344461 attggcgtgt cggcacttta ttgtcaaaca aaggacatgg ggtgctaaag cgctggctca 3344521 gagaccgact gaaagaatcg atcactttga aatgaaaccg gtcagcgttt catccgtata 3344581 acagatatgg tgaaaaaagg gagtgacgcg aagtgattgt gatcatctta ttgtttatat 3344641 ctattattgt ttttctttca gtcattcagc cgcagccctc gaaaaacaaa agccgccagc 3344701 aggcggacag cgggtatttc ggttattcag atcatagctc acaccatgat ggatgcagca 3344761 gtgacggagg tttcagcgat tccggctgtg gcggcggagg gggcggcgat taaacgccgc 3344821 ctttttttat ttcattgatt cgatgtacgc accaaaagcc gagcctgaca tgcctgggga 3344881 cacgcgcaca cgatggaggg catacattcc ctggtctctc gaagccgcgc ccggttctgt 3344941 cgtcacgccc atttgatagc ctgttttttc agcggccttc agcgtctcct cattgtagcg 3345001 ccctaccgga tagctgatga tggtggtttg ctgatgaaac atgttgtcga acagcttttt 3345061 cgaatcagcc atctcacttt gctgctgttg aggcgttaat ccgttcagct caaggtggtc 3345121 aatcgtatgg ctttcaatcg atatgccgtg ctgtgccatt tccttcattt gttcctctgt 3345181 cagatggtgc ttatgtccga tcgatttgcc gatcataaaa atcgttgcct tcatcccgta 3345241 ctttttcagc accggatacg catcttgata attgtcggtg tacccgtcat caaatgtgat 3345301 cagcacgcac ttctcactcg gttttttatc ctgcgtcagc atgagagatg cctctttcgg 3345361 cgttaatgtc tgatagccgt tatcatgaag ccacttcata tgcgcctcga attctttctt 3345421 tggcacacgg aggctgtttc ctgaagaaat gctgtggtac atcaaaatcg gcagctttgc 3345481 cggtttctct gttttgatcc atgcggatgt atcgtcttct tttttctgaa cttgtactgc 3345541 ctttttttcc ggtttctttt gttccgcttt tggcatcggc tgctctgcat tcgcctcttg 3345601 atcagcacaa gccgcaagag ccaaacagct gcccaaaaga aagatgctta aaaacaatcg 3345661 tttcatcgtt ctcctgcttt ctgtctattt cttcctcctt tttcatcggt ttgattctga 3345721 gattttcaat agcaaaaaac cggacatgtc tccatgtccg gtttttttga tcttatcgga 3345781 ttctcacttc tgtctcactg tcaaagaaat ggcctttatt catatcaaat gcaaccgtca 3345841 gctcatcgcc cgattgaata tcgaggcggg cgtcgatccg cgcaataaag tcttggttgt 3345901 ctatctgcga ataaatcata atttcagaac cgagcagctc tgcaacatta attttcgcct 3345961 taatcgaaga gttcttatat gattccacga caatcaattc atcatgtata tcctcaggac 3346021 ggatgccgaa gatgacctct ttgccgatgt agcctttttc acgcagcact ttcatttttc 3346081 cttccgggac ggttaatgcc gcagaaccga ttttgattaa gccatccgtg agctttcctt 3346141 tgaaaaaatt catcgccggt gatccgataa acccgccgac aaagacgttt tcagggaatt 3346201 catatacatc cttcggcgtc ccgatctgct gaattttccc atctttcatg actacaatcc 3346261 gtgtcgccat tgtcagcgct tctgtctggt catgcgtcac ataaatcgtt gtagtctgca 3346321 atctctggtg gagcttaatg atttccgccc gcatttgcac cctcagcttc gcgtccaggt 3346381 ttgacaaagg ctcatccatc aggaacacct ttgcatcccg cacgattgcc cggcccagcg 3346441 caacccgctg tctctgtccg cctgacagcg ctttcggttt acggtgcaaa tattcctcaa 3346501 gcccgagaat tttagcggct tcttcgactc tttttttgat ttcaggcttc ggcattttcc 3346561 gaagcttgag cccgaacgcg atattatcgt agaccgtcat atgcggataa agcgcgtagt 3346621 tctgaaatac catcgcgata tccctgtcct ttggcgctac atcattgacc cgttttcctt 3346681 caatataaaa atcacctttc gaaatttctt caagtcctgc gaccattcgc agcgtcgttg 3346741 atttcccgca gccggacggg ccgacgaata cgataaattc cttatcggca atatgaaggt 3346801 taaagtcatc aaccgccggt tccttctgat cataaaattt ataaatgtgc tccatccgca 3346861 attcagccat ctaacatccc cctttgttat tgtaaacgct ttcttatatt gagtgtaaca 3346921 gcaattccct ctcgctaaaa tgggcagcgt tcataaaatc acccagccat ttttcgtgca 3346981 tatttccaat ttattctgaa ctttcatttt gcaggcagat aaaataggca agaagcgcgc 3347041 ctttgtacga tttgatatct atccctgacc gctcaataaa tttatcaatc cgatattgca 3347101 ggctgttgcg atgcagatgc agctttttcg ctgttaatgt gacgtttgag ttgttttcaa 3347161 taaacagctt aatggtcttc cttagctcag attcacttcc aaataaaagc tcagcttctt 3347221 cagagagcag tgtttccagt ttttcttttt ctgtttctaa taatagaaaa ggaaagatca 3347281 tctcaaaggt cacactctgc acctgaggca gccgtttttc agcaaacagg aaatacgcct 3347341 gttcacgagc gtaatgtttt cgcagacact catccggctc gtaaaatctt ccggcgtaaa 3347401 aacggacact gaagtagaaa tcactttcaa gaaccttagc gagcgattcc agttcgtcct 3347461 tctccgccgc cgcttcactt tcctgctcga caatcacacc tctgtcctca tggatccaca 3347521 caatcacaaa agacaccggc caaaaatggc gaaccgcttc cgtaaaggac gtcctttcta 3347581 ttttgccgaa taaatgaaag tgaacaaatc tcgtccgttt ctttatatac gccggcaatt 3347641 cccctctgga aaaaaggaac gaaaaccact tgttttcctc aggtgatttc atagacagtt 3347701 gattgccctc atccgcaggc gtcaaaaatg actgcagcac caatacttct ttttcactga 3347761 tctctgtttt cggaatggag atatatctct gattgctctc atcaaaaaaa catagacagc 3347821 cttcccttat gcaaagctcc tcagacacaa tcgaaccggg ataaatagcc agcagcgatt 3347881 tcatagagtc tcctctctta tgtaaggatc tgtatattca gtataaggcg aaacacacat 3347941 gttctccact aaaaaagagt atatccggta tagatagacg agaaactgaa agggaaacct 3348001 cattcgttta catattggct tcagcggaaa tagaagaaga catgcaggac caaaggaggg 3348061 tcatcttatg agtttcgaaa cgttaaacaa aagttttatc aacggaaaat ggactggggg 3348121 agaaagcgga cgtacggagg acattttgaa tccgtatgac cagtctgtga tcacaacagc 3348181 atctttggca acgggcaaac agcttgagga tgcgtttgac attgcacaga aagcccaaaa 3348241 agagtgggcc aagagcacga cggaagaccg aaaagccgtg ctgcaaaaag cgcgcggcta 3348301 tttacacgaa aaccgtgatg acatcattat gatgatcgcc cgcgaaactg gcggaacgat 3348361 cattaaatca acaatcgagc tggaacaaac gattgcgatt ttagatgaag ccatgacgta 3348421 tactggtgaa ttaggcggcg tcaaagaggt gccatccgac attgaaggga aaaccaataa 3348481 gatttaccgc cttccgctag gtgtcatttc atcgatttct ccatttaatt tcccaatgaa 3348541 tctatccatg agatccattg cgcccgcaat tgcgctgggt aacagcgttg ttcacaagcc 3348601 tgatatccaa actgctattt ccggcgggac catcattgcg aaagcgtttg aacacgccgg 3348661 tcttcctgcc ggtgtcctta acgtcatgct gacggatgta aaggaaatcg gggacggcat 3348721 gctcaccaat ccaatcccga gattaatcag ctttacaggg tcaacagcag tcgggcgcca 3348781 catcggtgaa atcgccggtc gcgccttcaa acgaatggca cttgagctcg gcggcaacaa 3348841 tccatttgcc gttctttcag atgcggatgt cgatcgtgct gtggatgccg cgattttcgg 3348901 aaaatttatt caccagggac aaatctgtat gattatcaac aggatcatcg ttcatcaaga 3348961 tgtatacgat gagtttgtag aaaaattcac cgcccgtgtc aaacagcttc cgtacggcga 3349021 tcaaaccgat ccgaaaaccg ttgtcggccc gctgatcaac gagcgccaaa tcgagaaagc 3349081 gctggagatc attgagcagg caaagacaga cggcattgag cttgcggttg aaggaaaacg 3349141 cgtcggaaac gtgctgacgc cgtacgtctt tgtcggtgcg gacaacaaca gcaaaattgc 3349201 ccaaacggag ctgtttgccc caatcgcaac cattattaaa gctggcagcg accaggaagc 3349261 gattgacatg gcaaatgata ctgaatacgg cctcagctct gcggttttca cttctgattt 3349321 agaaaaaggc gaaaagttcg ccctgcaaat tgacagcggc atgacccatg tcaacgacca 3349381 gtccgtcaat gattcgccga atattgcctt tggcggaaac aaagcaagcg gtgtcggccg 3349441 tttcggcaat ccgtgggtcg tcgaggaatt taccgtgacg aaatggattt cgatacagaa 3349501 gcaataccgc aaatatccgt tctaaatgaa aaaatccctc tgtttcaagt acagagggat 3349561 ttttctttat ttagatatat ccacaaaccc ttcgccaaac acatcgcgta cgtcatgtac 3349621 gatcacaaac gcttttttgt cgcagcttct aatgattttt ttcagcatag acagctcctg 3349681 tttgttaatg acgatataca aaatctcttt tgactggccc gtataatttc ccttccctga 3349741 taaaatcgtc acgccccgat ccatcaaggt atttacctgc tctgcaatct cactcttatt 3349801 ttctgaaatg accgtaatgg cttttttcgt attcaaacct tcaataatga agtccatcac 3349861 tttggtaccg atatacagca tcacgatcgt aaacatcatt ttttctgcac caataataaa 3349921 ataagagcta aatactacga ttaaatcaaa aaacaagagt gcatagctga tattccagtc 3349981 taaatattta ttagcaattc tggccagaat cgcggaaccg gccgtcgtcc cgccgacccg 3350041 gataatcatg ccgatcccga ctccggcaaa tacacctgcg aaaatcgtat taatgatcaa 3350101 ttcatcagac ggaatgctcc acccatgtgt cagatgaaga aaaagcgaat ttgccgcaac 3350161 cgcaatgatc gtataaaccg ttgtttttcc atcaagaaac ttgtagccga ttaaaagcaa 3350221 aaacgcattt aagataaagt tcgtgacacc aggagaccat tgaaacagat aatacaaaat 3350281 cagcgtaatc ccagtgactc cgccttcccc aagatcattg ggaatcgcaa ataaattaac 3350341 cgcaagcgcg aagaaaaaag cgccaatcac aagcataagt acatccagca ttctcttttt 3350401 catcacgaaa acactccttt tcattgttct gttctagcaa ataaaaaaac ccaggagaac 3350461 gctctcgaaa aagagcagaa actcctgggc ttttatccca ccgtgtcata acagccaagc 3350521 tgctatgtgt tttctctcgg tcacagtcca atttgcattg cggaacccta gaaaaccact 3350581 gtttttatca tatccttttc actttccaat attagcatta taagggacgg ttcgaattgg 3350641 ttcaaggggt atttgcggag ttttcatcag ataagctgga aaaaaatacg atttatctat 3350701 taaaaaagaa cagatataac cgataagaaa aaaagcatat attttacaag cgaatgtaac 3350761 tataaatgat aataattata agaaattcat aattttatat tgactaagag aaataatata 3350821 ggcattatag tacatatgtt tcgtacattt tattacatag gaggaaatat aatggcagga 3350881 aaactagtac cctgtaaagc ttgcggtcaa gaaattgcaa agggtgtaaa aaaatgtcct 3350941 aactgcggta aggatcaacg taactttttt atgcgacata aaatcattac gtttattctc 3351001 gcagttgttg tcatcattat tatcggtaat atgattggcg gcggaggcgg ctcagaagcc 3351061 acttccaaaa catcaagcag cagcaaagca gaaactgaaa aaacatacaa tatcggtgat 3351121 accgtaaaaa ctgaaaaaac tgaagtgacg gttacgaagg tagaggacag agatactgtc 3351181 ggtactcaat atgttgaaaa gaaagcatct gagggaggta caattgtagc tgttcaatat 3351241 acaattaaaa acgtatctaa aaagccgatt agctcttttt caattccaac tgttaaatta 3351301 gttgatgctg atggtacttc ttatgattct gatattgatg cttctgtaaa ctatgcaact 3351361 gagacaaaag ttgataactc taaaattttg agtgatctaa atcctaatat taaagtaaca 3351421 ggtgtaaaag catttgaagt tgacaaggaa gcttatgcaa aaggcacttg gaaactaaaa 3351481 ttcagtaatg atgttattgt gaaaatcaaa taacagctaa caagggtgcc tgtttaggca 3351541 cccttgttct ttaaaaaagg ccttctcaat tgagaaggcc tccattctta ttccgcactc 3351601 ttatacccat tcacattaga agactgccat ctccaggaat cagcacacat ttcctcaagg 3351661 ccgcgtttcg cttcccagcc tagttctcgc ttggctttcg caggatctgc aaagcatgtg 3351721 gcgatgtctc ccggacggcg gtccgcaaaa cggtatggaa cctctttccc tgacactttt 3351781 tcaaaggctt tgaccatttc cagcacgctg tagcctgtgc ctgttccaag gttgtatgca 3351841 tcggctcctg tagagttcaa tactttttcc agcgccttga cgtggccttc tgcgagatca 3351901 acgacgtgaa tataatcgcg tacgcctgtc ccgtcttttg tcggatagtc atttccgaat 3351961 acgcttaatt gctcgagctt cccgactgct acctgtgcca catacggcat aaggttattt 3352021 gggattccgt tcgggtcttc accgatccgt ccgcttggat gcgcgccgaa cgggttaaag 3352081 taacgaagca gcgcaacgct ccactcattg tcggctgtat gcaaatcacg caatatttgt 3352141 tcaagcatga gcttcgtctg cccataagga tttgtcgcgc ctaatggaaa gtcttccgta 3352201 atcggcgatg tttccggaac gccgtatact gtcgcagatg aactgaatac gattttcttg 3352261 acgccgtatt tctccatggc ctcgcataaa ataaacgttc ctgtcaaatt gttatgataa 3352321 tatttgaggg gaatcgccac agattcgccg actgctttta accctgcaaa atgaatcaca 3352381 gcttcgattt cattttcagc aaaaacggaa tctaccgctt cccggtccaa taaatccgct 3352441 tcgtagaacg ttaaatcttt tcctgtaatc tccttgacac ggttcagcgc ttcagctgaa 3352501 ctgttggaca gattatcaag aacaacaatc tcgtagccgc tgttcaatag ttcaacacat 3352561 gtgtggctgc caatgtaacc ggcaccgcca gtaacaagta ttgccatgat gtaaaccctc 3352621 ctaaaaaatg acctgttttc attatatagt gtttagaacc ggtccacatc catttttaag 3352681 aagtttaatc gtttattaat agttttttca tattttttag cttaaaccct tgccagcaat 3352741 tcgatagagg tttcagcaag aatgtgctct ttcatttctt gatagagctc attcaagtaa 3352801 aagcccggct gaagattcag ctcagcatct aaagcataga ccgtcaatgt atacgcatga 3352861 tccttgtcag gcggtgtcgg cccgcaatac tggtgaatca cctttggatc gttgcttccc 3352921 gcaagcggtg aagcaaagct gttttgccct tgtatcatca agtcctgtct ttcctcactc 3352981 gcatgttcag gaagctctcc gatgtaagcc ggaatattag ccgctgtcca gtgaatccag 3353041 ctgaatccgc atacgggaat ggcgtcatga tcgatgaaag taagtgcgag cgtctttgct 3353101 ccggacggga tgtcatcaaa atgaattgga aaggatacaa atgggtttcc ttctctctta 3353161 tatttttcat ccgcgtattt tgaatacttg tcatgtaaat atggatttgc ttctacgtat 3353221 atgttcatat gaatccctct ctctattttc tcgttctata ggtatactaa acgaatcgat 3353281 gtataatcag tgataaacaa atacgcatgt aaacgtaaca atttgttatg gataacttgc 3353341 agtgaaggag atatttcatg gatttaaaat ggctgcaaac ctttattgcc gcagcggaat 3353401 cagagagctt cagggaggcg gctgagcatc tgtatctcac acagcctgcc gtttctcagc 3353461 atatgaggaa attggaagat gaactggaca tgaggttgtt tttgcatagc ggaagacgag 3353521 tcgtactgac tgacgaaggc aggctctttt tgccttatgc caaagaaatg atccatgttt 3353581 accaagctgg aaagcagaaa gtcagtcaat ggaaacaggg gtacagccga tcactcacgc 3353641 tggccgtaca cccctacatt gcgtcctata tcttgcctcg ctttctgcca gcctatatcc 3353701 aaaaacatcc gcatgtcgag ctttcaactc atgtggctgg atctgacgct attaaacaag 3353761 cggtggaaca caatgaagct gatattggtt tgtcgcggaa agacccgaac accaacactc 3353821 tttattatca gcatatatgc gaaggtacgc tttgtctggc ggctcctttc caagaaagca 3353881 gaccggatgc tgcatccgtc ttaacccgct atcggctgct aacgcatgat catccgtcat 3353941 atggggatgc ctttttagat aacatccgat cacattaccc gtatcttcaa atgatggctg 3354001 tcgggcagac ggatacggct gtccacatga tgaaagcggg aatgggggca tctttcctcc 3354061 ctacctacat tatcaaacag gaagaagccg aaaaaaagct gatggctgtc agcacgcctg 3354121 cacatctaga attgcctgcg tcccaaacgt ttatgatgtg gaaaagaaac agcgaagaca 3354181 ttcagcattt tcacgccatg ttacatgact ttatgcagcg cgaacaagta tagagctgaa 3354241 aaatcaatct gccggttgac gtttttcttt cctattttcg ctatgcttaa tgcagaaagg 3354301 atttgatgac atggcgatga gcccttatat ttttattgta ttgattctta ttattttatc 3354361 gatgtatcga gaaagaacgg taaagcccgg gaagttgctg atcattccac tgttgctctt 3354421 atggggcgta tctgcatcgt ttcagccggc gtattttcat tccgtattac atgtggcgat 3354481 cagcggcatt ttattactga tcgggctggc ctgcgggttt ggcattggga agatggtaaa 3354541 tgtacggatt cacccggaaa ccggaaaggt cacttcacgc ggctcacttg ggagtgttat 3354601 cctcattcta gtgatacttt ctttgcgcat ggccgcgaga acatggctgc ctgagagcaa 3354661 cgagatgttt attgccatta ttcattctat gttcttcgtt cccctcggca ccatcacagc 3354721 ccgcaacatc atgctttaca aagcatacag acgactgacc gctggcaaag tatccattca 3354781 ataaccgaaa gaaggaccag catgaacgga caaactccgg ctcggcacta ctacaagaag 3354841 cttgtgccga gccttattct cattttgaat tgcatacaat ttttatctca tccaactaag 3354901 gctgatccca ttttgttagc atttgtattt gcggtatact tagcattcat ttggatcatt 3354961 ccctatgtgg catccactgc tgttagtttg agcatattca tcggactctg gctcctgacc 3355021 gatttctttt gggctgtttc cggccaagag cagggtgccg cctatttttt gattgtattt 3355081 ttaatgatat atgccgcctt tagactccct tcacggctat ccttgatctt cacagcatgt 3355141 ttaattggag gcaacatatt actcctatcc tcacaagggg gaagcttgaa taccatcatc 3355201 agcaacatct cgatcatgct cggtctgtac gtcctcttct cctccatgcg tttcagacga 3355261 gaagcgagaa gggaggctga acggaatcat gctgaattgg caaaaatgca tgtgcagctg 3355321 gagcatgctc ataaagaact ccagaaagcg catgcagagc tgcaggaggc ttctgttctt 3355381 tcattaaggt acgcggtcct tgaggaacgt acaagaattg cccgcgacat tcatgacagc 3355441 atcggtcacg agctgacttc tgtgattgtt cagcttcaat cccttcccta tatccttaaa 3355501 agcagcaagg aggattcaga aaaagtcatt caaaatgtac tgagtgtcgc cagggagtgt 3355561 cttcaagaag tgcggtctgt tgttcaccaa atgggccgta gtgaatcgat ggtggggctt 3355621 accgctttgc gggggctcat tcatcaagtg gaggaacgga gcggcttgca cgtttcttta 3355681 gatactgccg gactgtcaga agagtcttgg cctccaaacg tgagcgaaac gatctaccgc 3355741 atcttgcagg aagcgctgac caatatcatt cgtcacgctg acgcttctca tgcggcggcc 3355801 gtcatttcta atgacaagtc ccatctctat gtcacaatca ccgacgacgg acaattcacc 3355861 ggcagcctta cttatggatt tggcctgaca ggaatgaaag agcgcgcaga aaaagcaggc 3355921 ggttccctta ctttcagtgc cgtacagccg agcggcctga aaattgagct gtcattgccg 3355981 ctcatgacaa cgaataagga gcaaaaagat gaacaaagat aaaatacgcg tagcgcttgc 3356041 cgatgatcag ccgcttgtgc gtgaaggctt ccgctacgtc atcaacgcac agacggatat 3356101 gacggtttct ggcgaggccg gcgacggtca cgatattata gcactcgcaa aacaaacaaa 3356161 acccgatgtc atcctcatgg atgtccagat gccgcgttgc tcaggcatcg aagcggcgaa 3356221 agacattatg tccgcacttc caaatacaaa gatagtcatt ttaaccacct ttgacacgga 3356281 agaatacgta tttgaaggca tccgtgcggg cgcagtcggc tatctgctga aggatacact 3356341 tcctgaggag ttgatagatg cgattcgcgc tgcggccaga ggcgaggcga ttttccgtac 3356401 agtcacagct gctaaaatca tcagtgagac atttcgggcg aaacagcaaa ctcatgccga 3356461 agaactggca gagccgttca ccaaaagaga gcttgaggtt cttcagcaaa tggcctacgg 3356521 actgagaaat gaggatattg ctgaaaagct tttcgtcagt gaaagcactg tgaaaaccca 3356581 cgtgcaccgc atcctgcaaa aatgcaatgc ccaagaccgg acacaggcag tcgtttttgc 3356641 cattcgaaac ggtattgtgc aatagaaatc tctcatcccg ccatgctaaa ataagacaaa 3356701 ggagatgatt ggaaatgaaa gaagaaatca ttgaacggtt tactacatat gtaaaagtcg 3356761 atacacagtc cgatgaatcc gttgacactt gtccttccac acccggccaa ttgacattag 3356821 gaaacatgct agttgatgaa ttgaagtcca tcggcatgca ggatgcagcc attgatgaaa 3356881 acggctatgt catggcaact cttccctcca atactgaaaa agacgtgccg acaatcggct 3356941 ttctcgctca cgtcgacacc gctacagact ttaccggcaa aaatgtgaat ccgcaaatca 3357001 tcgaaagcta tgatggaaaa gacatcgttc ttaacgaaca gctgcaggtc accctgtcac 3357061 ctgatcaatt ccctgagctg tccggctata agggccatac actcatcacc acagacggca 3357121 ccacccttct cggcgcagac aataaggccg gtatcgctga aatcatgaca gccatggatt 3357181 acctcatcaa acaccctgaa atcaagcacg gcacaatcag agtcgccttt acgcctgatg 3357241 aagaaatcgg aagagggccg cacaaatttg atgtgaaacg gttcaatgca tcctttgcct 3357301 acacggttga cggcgggccg ctcggcgagc ttgaatatga aagcttcaat gccgctgccg 3357361 caaaaattac gattaaaggc aacaacgtac atcccggaac agctaaagga aaaatgatca 3357421 actctgcgaa aatcgcgatg aagctgaaca gcctgctgcc ggcagacgaa gcgcctgaat 3357481 atacggaagg ttatgaaggc ttctaccacc tgctgtcgat tcaaggagac gtagaggaaa 3357541 caaagctcca ctacattatc agagactttg acaaagagaa tttccaaaac agaaaagaaa 3357601 caatgaagcg tgccgttgaa gaacttcaaa acgaatacgg gcaagaccgg attctgctgg 3357661 atatgaacga ccaatactac aacatgagag agaaaattga acctgtcatc gaaatcgtca 3357721 acattgccaa gcaagcgatg gaaaacctcg gcatcgaacc gaagatttcc cccatccgcg 3357781 gcggaaccga cggatcacag ctgtcctaca tggggcttcc gacgccaaac atctttacag 3357841 gcggggaaaa cttccacggc aaatttgaat acatctcagt tgacaacatg gtcaaagccg 3357901 taaatgtcat cgttgagatt gcaaagcagt ttgaagcgca agcataacgc caaaagccag 3357961 tccaaaaaag gactggcttt tttgtgtgaa aatgaaacat tttaaacacg tcctccgtaa 3358021 aacaagtatc aacaaatgag gaggaaaaac aatgacaaaa catgcaatcg ctgccaagag 3358081 tctcttgaaa aaatggatca tttccaggcc gcttaacatg aaaaagaaat ccagcccatt 3358141 tcaaaaaatc agaaaaatgt tcaaacgctt cttcaaataa aacatcaaat cccctaaata 3358201 caatccgtat tcacccgtac cgcccaaatg ctccgtaatt tgggtttttt gtgttcaatt 3358261 ccgcaaaata gggtataaac caaacaagca agaaaacagc acccaaaaac aggtaattcg 3358321 aattacgtaa acttaggtta aaagttatat aaaggaattt attttatcgt cgatagtaac 3358381 tatagaacca atcatcaaca agagcaaaca gcgtaattca agactatttt caggtcatca 3358441 ggtaatactg ttttagaggg acagtttctt gttatttatt gatttagaat tttttgaata 3358501 ctttttggca ttttatccgt acaatagaga gtaccaaaac tttttttggg aggtatgtaa 3358561 tatgatccta tttattatca tcgcattatg cggctatctt cttttttctt tcagcaagga 3358621 caatcgccgc aaaccgcaaa agacaagccc tctgccagca gccgcacctc atcacaacaa 3358681 cctaatcgac cttgacgcca tccgccaaaa acgccggatg catctttcct aattctatat 3358741 ttcaaacgaa aaggctgctg aatcacgcag ccttttaaaa ttgttttgat ttagagcctg 3358801 aaaccttttc gccacctatc cgtaatttca tacaaggcaa acccaaagga gacttcagca 3358861 atgatcgagt tatttatgaa acaaaaaatg ttctcattta aagatgcatt tcacatttat 3358921 gaccgggatg aacaagaaac attcaaggtg gaggggcgtt ttttctcgtt aggagactca 3358981 ttacaaatga cagactcatc tgggaaaacg ctcgtttcca tagaacaaaa actaatgtct 3359041 ttattgccgc gctatgagat ttcaattggc gggaaaacag tttgtgaggt aacgaagaaa 3359101 gtaacgtttt ccaaaccgaa atttgtgatt tccgggctta actgggaaat agatggtgat 3359161 ttatggaggg atgaattcca actgacggac ggggaaaatg tccggatgtc agtgagcaaa 3359221 aagtggctca gttggggtga ttcctatcac ttgcagattg catacgagga agatgttctg 3359281 atttgcactg ccatcgctat cgtgcttgat atggttttat ataacgatga agatgaaagt 3359341 attttctaaa aagcattgac aattgatcca aaagtaataa tattaagata attgaaatct 3359401 gaatatgaag ttgtacctta tcaagagagg tggagggact ggccctatga tacccggcaa 3359461 ccgctgtttc aaacagaatg gtgctaaatc cttaagaaca ttgcgttctt gcagatgagg 3359521 cggagatttg atcgttcaag ctcttcctta cacaaaggaa gagcttttta catgcttaat 3359581 atttcagaaa agaggcgaat aacatggctc aacaaacgaa tgttgcagga caaaaaacag 3359641 aaaaacaacg caaagcacct ttccgcgccg atcatgtcgg cagcttgctt cgttccgttc 3359701 cggtaaagga agcccggcaa aaaaaagcgg ctggtgagat gacagcggaa cagcttcgtg 3359761 atatcgaaaa tcaagagatc acccgcatcg tggaaaaaca aaaagaaatc ggtctcgatg 3359821 tggtaacaga cggggaattc cggcgttcct ggtggcatta tgacttcctg gaagggcttg 3359881 acggtgtgga accgttcatc ccggctgagg ggattcagtt ccataacaca aaaacgaaag 3359941 cgcgcagcat caaagtgacg ggaaaactcg attttacgag ccacccagcg ctcggtgatt 3360001 atcaattttt acatgagatt gccggtaacg cgacgccaaa attgaccatt cccagtccaa 3360061 atatgctgtt ttttggcgaa aaggcggata aagggattta tgacgatcaa gaggaatact 3360121 ttcatgatat ggcccaagcg tacaaaaaag caatcaaagc cttctatgat gctggctgcc 3360181 gttatctcca gcttgatgat acgtcatggt ctctcttctt tgaggacaaa ggcagagagg 3360241 ttgtccgggc gctcggcggt gatccagaaa cattgccagc catatttgcc aaaacaatta 3360301 acgatgccgt cgcagaccgg cctgacgatt taacgatcac aatgcacatt tgccgcggca 3360361 acttccgctc aacctgggcg gcatcaggag ggtacgacgc tgtagcggaa acgattttgg 3360421 acggcttaaa ccttgacggc cttttcttgg aatacgatga tgaccgctcc ggaaactttg 3360481 atccgctccg ttttgtgaag cgcaaggatc tgcaaattgt gctcggcttg atcacatcga 3360541 aatacggcga gcttgaaaat cctgaggatg tgaaacgccg tatcaatgaa gccgcgcgtt 3360601 ttgtcagctt ggaccagcta tgcctgagcc cgcagtgcgg tttcgcctct acagaagaag 3360661 gcaaccttct gacagaggag cagcaatggg caaagctgcg ccatgtcatc gacattgcca 3360721 acgatgtgtg gagataatct atcattgaca gaaatagaaa atgtgtgaat aatagatact 3360781 atcagaaaat ttaataaaaa ggttttcctt atcaagagag gtggagggac tggccctgcg 3360841 atacccggca accgctgttt aacagaatgg tgctaaatcc tttagagcaa tgattgctct 3360901 tgaagataag gttgagattg tcacgcaagc tcttccttat ccaaaggaag agctttttta 3360961 tatttgaatg gaaagaagga atggacaaca tgtcacaaca aacaacaccc gcagaacaaa 3361021 aatcacttca aagaaaaaaa ccgccgtttc gcgcggatca agtcggaagc ctgctaagat 3361081 ctgagcccgt caaaaaagcg cggctgcaaa aagcggccgg cgaaatgacc gctgagcagc 3361141 ttcgccaaat tgaaaacgac gaaatcatcc gcattgtgga aaaacagaag gaaaccggcc 3361201 tgaacgtcgt gacagacggt gaattccgca gagcatggtg gcactttgat ttcctggaaa 3361261 acttagatgg cgttgagccg tttactcctg agcaaggcat tcaattccat aacgtacaga 3361321 caaaagcacg cggcattaaa gtcacaggcg atatcgactt ttcaactcac ccaatgcttg 3361381 aagattactc atttctccat agcattgccg gtgacgcgac gccaaagatg acgattccaa 3361441 gtccgaatat gctgtttttc cgcggaaaac tggaaaagga tgaatacaaa aacgattatc 3361501 aacttttcca gcacgatgta tccaaagcat ataaaaaagc gattcaagcg ttttatgaca 3361561 gaggctgccg ctacctccag cttgatgata cagcgtgggc cgttttctta tcagaaaaag 3361621 gcttaaaaca aatcgaagcg ttcggaacaa cgcctgacga gcttcgccag ctgtttgcga 3361681 aatccattaa cgacgcgatt gcagaccgcc cggatgactt gacggtaacc atgcatattt 3361741 gccgcggcaa cttccagtcc acttggacag cggaaggcgg ctatgacgca gcagccgaaa 3361801 ccatttttga cggcttgaat cttgacggac ttttcttaga gtatgatgat tcacgctcag 3361861 gcggatttga gccgctccgt tacgtaaaac ggtctgatct tcagcttgtt cttggcttag 3361921 tgacatctaa attcggtgag cttgaaaatc cggatgacgt gaaacgccgt atcgaagaag 3361981 cgtcccgtta tgtaagctta gaccagcttt gcctcagccc tcaatgcgga ttcgcttcaa 3362041 ctgaggaagg caacaagctg actgaagaac agcaatgggc gaagctccgc catgtggttg 3362101 agatcgctaa tgatgtttgg aaataagcaa agaaaaaaac acacttgatt ccctagcgga 3362161 gcaagtgtgt tttttatgtc attgtgcggt gtagccccca tcaaggacga cagcctgccc 3362221 agtgacgccc ttcgccttct cgcttgccaa aaacacggca taatccgcaa tttccttgac 3362281 ggaaagcagt cgcttttgcg gcacaagcgg aaaaatgact tgttcaagta cagagtcgta 3362341 agggacattt ctagttttcg atagatcgct aagctgattg cgtacaagct gggtatcgac 3362401 ataacccgga cagagcgcat tgactgttat gccgtggggc gcgccttcca gcgcccctac 3362461 ttttgtgagt ccaatgacgc cgtgcttggc gctattataa gcggatttcc ctgcaaagcc 3362521 cactaatcca ttaacagacg caatattaat gattctgcca aactgctgtt ttttcatgat 3362581 cggaaaaaca tgcttcattg caataaaggg agccgtcagc atgaccttga tcagctgttc 3362641 aaaggtgtct gtcggaaact cttcaatcgg agcgacgtgc tgaataccgg cattgttcac 3362701 cagaatatcc aagcggccgt attgtttttg gatgacgttc accgtatcag caacttgcgc 3362761 ttcctttgtc acatcatacg gaatggccgc cgcgtcaaag ccttcttctg caagcttgga 3362821 ggctgctttt tcacatgctt ccggacggag gtctgaaacg atgacgctgg caccttcccg 3362881 ggcgaattct cttgcgattt cgaatccgat tccgccggca gcccctgtca ccaaagcgac 3362941 ttgttttctc atgtcaaaca ccttcccatt aagaattgag tacagactgg cttacagcga 3363001 aatcagcttc tgttttttca taaacctctt caattgtgac accatcctga agctccgtca 3363061 gtgtcatgcg gccgttcaca aaatcaaata cagccaaatc cgtaatcagc ctgtgtacga 3363121 ctttctggcc tgtcagcgga agggagcatg tttttttcac ctttgattca ccatgcttat 3363181 tgacgtgctc catgatgaca acgattcgtt tcgccccgtt gacgagatcc atggcgccgc 3363241 ccatcccttt taccattttg cccgggatca tccaattggc caaatccccc tgctccgaaa 3363301 cctccattcc gccgagaata gctaaatcga tatgcccgcc tcttatcatc gcgaatgact 3363361 cagcgctgtc aaaataagag gcgcctgtca cttcagtgat cgtttccttt cccgcattga 3363421 tcaaatccgc gtcttccgtt ccttccagag gataggggcc aattccgagc aagccgtttt 3363481 ccgactgaag catgacgtga acgccatcgg gtatctcatt tgcgacaagc gtcggcattc 3363541 caatcccgag attcacattc atgccgtcct tgatttcttg tacagcccgt ttgaccattc 3363601 gttttctcgc ttccttcact tggcctcacc ctttcccgat gcttgctgaa ctgttcgttt 3363661 ttcaatccgt ttttcttggc tcgcgccaag cacgacatgc tgtacgtaaa ttcccggcgt 3363721 atggatgtga tctggatcga gctctcctgc ttccacgatt tcttccgcct cggcaatcgt 3363781 gatcttgcct gccatggcgg caatgggatt gaaatttctc gccgttttcc taaaaatcaa 3363841 attgcccatg gtgtccgctt tccacgcttt gacgatcgcc acatcgccgg taatgcctcg 3363901 ctccagcaca taagtccggc cgccgaatgt tttatgttct tttccctcgg ctatggaggt 3363961 gccgacgcct gtcgccgtat aaaatcccgg tatgcctgca ccgcctgcac gaattctctc 3364021 agcgagcgtt ccttggggaa caagctctac ctcaagctct ccgcttaaaa actgccgctc 3364081 aaaaatttta ttttcaccga cataggaagc gatcattttc ttgatttgct tgttagccag 3364141 aagcaaacca agcccccagt catcgactcc gcagttattg ctgacaacgg ttaaatcctt 3364201 tactccctga tctcttatag acaaaatgag ctgttcaggg atgccgcaca gcccaaaccc 3364261 tcccgcgatc agcgtatccc catcatgaat cagtttcgca gcttccttgc ttgatgacag 3364321 cacttttccc atattgatgc ccctttcgtt ttcttctaca ctagaccagt caggctgtaa 3364381 atcgcgatca cagcaaatac ggcagccgtt ttaatgagcg tgatcgcaaa aatatcgcga 3364441 taggattgcc ggtgggtcaa acccgtcacg gccagaagcg tgataacggc gccattatgc 3364501 ggcagtgtat ccatcccgcc tgatgccatt gaaatgaccc gatgcatcac ctctggcgga 3364561 atattgtaag cctgaatcgc ctgtaagtat tgttctgaca tcgcgcttaa cgcaatgccc 3364621 attcctcccg aagccgagcc ggtgattccc gccagcgcag ttgtcgtaac ggcgccattt 3364681 acaagcggat cggtaaaagt atgtgaaatt ccgctgctca gcttatgaaa ccccggcagc 3364741 gcggcgataa tgccgccgaa cccgtactca gcacccgtat tcatagatgc cagcaaggcg 3364801 ccgccaattc cttcattcag cccttccttc aattgggcaa acacacttct ccaatcaaat 3364861 aatatcgttg tgatgatgcc aatcactaaa gcaatctcca ccgaccaaat agcagccgct 3364921 gaagaaatat caagcctgcc gaactccttt aatcctatgg aagaaaaatc aaatccattc 3364981 ggataccact ttggcaggta aatggtgaaa tatttattca ctgcaccgac gagaataagc 3365041 gggacaaagg caagcgcgtg ccgaatcggg cttttgtccg gttcagccgc ggactcaatc 3365101 gattcaggag caggagcatt ctgcgaatca aaaccgccat agccttcgcc agatgcctgc 3365161 gctttcttcc gccttgattc caaatagagc atcccagctg ccagcacaat cactgcgccc 3365221 atcaaaccca gccaaggggc ggcataaatg tctgttttga aaaacgacgt cgggatgaca 3365281 ttttggattt gcggcgttcc cggaagtgcg tccatcgtaa acgtaaaagc tcctaaagca 3365341 atcgtacccg ggatgaggcg ttttggtatg tttgcttctt ggaacatgtt tttcgcaaaa 3365401 ggatatacag caaatacgac aacaaacagg ctgacaccgc tgtacgtcaa gacagcaccc 3365461 atcagcacaa tggcaagtat cgctcttttt gccccgacaa gccggacaat tgttttcgcg 3365521 attgatgccg caagcccggc catttcaacg acctttccaa aaatagcacc gagcaaaaac 3365581 actgggaaat acagcttaat aaaacccgcc atcttctcca taaaaattga tgaaaaaaaa 3365641 ggaagcacat ggcttggatc tgtcagcagc accgcgaata acgcgcaaat cggcgcaaac 3365701 aatatgacag aaaatccccg atacgccgta aacatcagca aacctaacgc caatagaatg 3365761 atgatcagtt ccacacacac atcccccgtt tccgcgaact agaaagcgtt tacaaaaacc 3365821 tgtccgcatc ggctgtttcc gtcccctttc catatgtacg agaagcgtgg gccaactatt 3365881 ccgattaaaa aaggaaagct ccttttttcg gagctttcct ctaccattca tttcattcct 3365941 attaggatat caacatcaac cgtaatatcg gctgatttca tctctttcag caggctgact 3366001 cgatctttcg gcgccgacca ggcaagcggc gtcatcttga gaagccagtg gatcgcctgc 3366061 tggtcaagcg ttttaacata gcgcagcctg acaggacggc tgtgtgctgc atttgctgta 3366121 aaacgctcaa ctgctgccgt attggaatac gtgcgccttg gtgaatcagt atataaaaat 3366181 tgccttaatt ctattaaata gtcgcttcgc ggcactactt ttatgagcat gccatcattc 3366241 ttcagcagtc tatgaaactc tgcataattg gacggcgaaa aaatagacag aacaacatca 3366301 aattggcgat catgaaaagg agcacgcgcc acatcggcaa ccgcccacat cagatctttg 3366361 aatgccttag aagcttttaa gatcccgtcc ttcgaaagat ctatgccggt tcctatcgct 3366421 gctttccctg cataatcaaa cccgcaaagc gcattcaaat gagaaccctc accgcaaccg 3366481 ctgtccaaga tggtgaatgc ctcatgacca gatttgggat gactgatgag ctctgcaatc 3366541 gcatcatgga gcgggtcaaa aaaaccacat tctccaatca gcctgctcct cgcttcaaaa 3366601 agctcggcac cgtaactggt tttgaccggc ttcgtcagaa agttcacgta gccgtgccga 3366661 gatagatcaa atgtatgtcc tcgttctgta caaatcaagc ttttccctga tgccgcatcc 3366721 atagaagaat cgcagagcgg gcatcgaaac atgctgaaat caactgttcg cttcatgata 3366781 aaaaacaccc cattcattca tttttagata aatgaaaaag gcatagacaa ataaacctag 3366841 gcctatctca aaaattggcc aggtctggca gtttgtctac acctgtcatt atctataacg 3366901 aatgaattgg ataatcatga aaaaaactcc ctttctgctg tatgggtttc cccgtttcca 3366961 tcatacaaca aatatccagg agctggaacc ttatagtgaa gaaaaatcag tactgacatg 3367021 ctggtatccc gccaacatca tatcagcata gcaatccagc atgtttttcc tttattttct 3367081 cattttagaa tataaatttt attattgtga aaatagttaa aaaggttgat tttcaaaaag 3367141 tgaaaggata aaatactgct atcatcttag aaaaagacat tcttgtatat gatcagtaat 3367201 atggtctgat tgtttctacc tagtaaccgt aaaaaactag actacaagaa agtttgaata 3367261 aatttgaacg agttgaaaag gacaagttct tttctgtttg ctcttatttt tcacactttc 3367321 tgcacttcca gaatttgtga aggataagag ctttttttgt ttccataata accctcatag 3367381 gagttgctat catgtacttt ttactaaacc ttgtcggtct cattgtgatt atggcagttg 3367441 tattcctatg ttctccgcag aaaaagaaaa tcaagtggcg cccgatcatt acgttaattg 3367501 ttctggaatt gctgattact tggtttatgc tgggaacaaa agtcggaagc tgggccatcg 3367561 gtaaaatcgg tgatttcttc acttggctga ttgcttgcgc cagtgacggt atcgcgtttg 3367621 cctttccgtc agtgatggcg aatgaaacag tagacttttt ctttagtgcg cttcttccaa 3367681 ttatctttat cgtcacattc tttgatattt taacgtattt cggcattttg ccttggctga 3367741 ttgataaaat cggatgggtg atttcaaagg cttcccgctt gccgaaatta gaaagctttt 3367801 tctctattca aatgatgttc cttggaaata ccgaagcact tgcggtcatc cgccagcagc 3367861 ttacggtttt aagcaacaac cgcctgctca cattcggttt aatgagcatg agcagcatca 3367921 gcggctccat tatcggatct tatctttcaa tggtgcctgc gacatacgtg tttacagcca 3367981 ttcctttgaa ctgcttaaac gcgctgatta tcgcaaacct gctgaatcct gttcacgtgc 3368041 cggaggatga agatatcatc tatacaccgc ctaaagaaga gaagaaagac tttttctcta 3368101 cgatttctaa cagtatgctt gtcggcatga acatggttat cgttattttg gcaatggtga 3368161 tcggatatgt cgcattaacg tcagcagtta atggcattct tggcgttttc gtacatggcc 3368221 tgaccatcca gacaattttt gcttatctgt tcagtccgtt cgcattcctg cttggactgc 3368281 cagtgcacga tgcgatgtat gttgctcagc tgatgggcat gaaattagca acgaacgagt 3368341 ttgttgcgat gcttgacttg aaaaacaatc tcaaatccct tccgcctcac accgttgcgg 3368401 tggcgacgac attcctgacg tcctttgcaa acttcagtac tgtcggcatg atttacggca 3368461 cgtacaattc gatccttgac ggagaaaagt caacggtcat cgggagaaac gtgtggaaac 3368521 tgctcgtcag cggaattgcg gtatctttat taagtgctgc gattgtcggc ctgtttgtgt 3368581 ggtagaaaca ttgagccata tcccttttcg gatatggctc ttttcattat tgataaatag 3368641 aggctggcac ctgcacatcc cggattcccg ctgcataagg ccccaagtca tactggccga 3368701 agacgatggc gatcccgttt gccgtaaagt aaaacattgt gtctctgttt agggttatat 3368761 cctctttctt tacatcagag aaaaacagca catcgtgttt tttgatatag ctatataggt 3368821 aatctctcgt tttgctgact tttgttttgg tgttcagaat ctgatccagc gtcacccgct 3368881 tttgtgcttt caagtcatag ttgaaggact ggacagacgt tagaccgtgg gcgccccctg 3368941 aatagatata attgagtgtt tgaatgctga gcttgcctgc cgcattgtat ttgacgctga 3369001 aggatgtttg atattcccgt tttaaagccc tgctgttcgc ctgctttttt gtttttcagg 3369061 tattcctgat acgattgttc atgtaggctt tcagctcttg attgattttc ttttcaaacg 3369121 cggcattccc gacgtgatgc acttgtggat acgttaactc cttgatcttt ttgtacgtat 3369181 gggtgctgac agtcggtgtt ttcgcttgaa ctgcttttaa agatggggcc gcatatgcaa 3369241 atacagaaaa aagcaagact gcaatgcccg cggctttcag catgttattc catttcatac 3369301 aatctactcc tttgatgtcg ttgtttatca ttcccttatt taagcaatac acacttttat 3369361 agactgatta aatcgaaaga agtttctagg tctaacagca tgatttttcc aataaaaaaa 3369421 gagacacagg atgtctcttt ttttactgtt tgcgcccaga aatcgcttca tgaagggctt 3369481 gtgccaaatc tgtatttccg aacatctcta ataccgcaat gacagtctgg tccggaatgt 3369541 gctctgcttc gtgttttggc acgaccagat cgtccatggt ttttttcaag ctttcattca 3369601 gcttttgctg cggatacgct ttggcgtaca gctccatcgg atcaagatca tggttcacgc 3369661 accactgggc aaacaccaaa atcatcatat tttcatcgcg ttcgtaagct tcagtgagct 3369721 gtttttcgtt catttgtcat gctccttatg aaaagtatct tccttaaaga tacaggagcc 3369781 gatcaaattc gtctatccca atggcgatga gcagcaaccg catcgataaa tgccttgctg 3369841 aaagcggtgt agtcaggttc atctttagcc gttacgatgc ctagcccctc tgttgtcccg 3369901 acagaggatt gaagaaggtc aattccttca tttgccgcac cgatcgcctt gtagtgattg 3369961 taagcttctc tgataaacgc catcgcttgt ttgttgtctt ttaactccag tcctcctgcg 3370021 gcatagacgg catcatacag aacagaatca accgtcagga acgtgccgct ggcctcaagc 3370081 tgctgtccgc tgccgcttgt catatacccc agattttgac tgatgatatc cactgtgatt 3370141 ccttcttgct ttaaggcttc cagtactgtt tgcagctctt tttcatgaaa tccgtttccg 3370201 gcgagtacag cgacttttct tgttgacgcg gttttcactg tacgggcttg gcttaacgca 3370261 ggcgaagtaa gaatttcttt agatgcttta cgcttcgcgg gcgccgccac gcctactcct 3370321 ttggcgattt cttctgctaa atctgcatcg acattgctga agacatcaac gacctgccgc 3370381 tgtacgtctt tgcttttgac cttcccgacc tcgaagcaga aagcagaaat gatgtgctgt 3370441 ttctccacag gagacatgct gttccagaaa agcttcgcct gtgagtaata atcgttgaag 3370501 ctgtcgcttc gctggcggat ttttttgccc tcgacttttt cctgatagtg gacgtagccg 3370561 ccttcttcag ctgtcgcagg cgacggatca ttgttttgca gtgagttttt atgataagcg 3370621 acaggtccct tattgatcgt catccggtga tagccgtcgt attggttgtt atggaatgga 3370681 cagaccggcc ggttaatcgg aatctcatgg aagttcgggc cgccaagacg gatgagctgt 3370741 gtatccgtat aagagaaaag ccgcccctgc aatagcgggt cattggtaaa atcgatgccc 3370801 ggcacgacat ttcccgggtg gaatgcgact tgttctgttt ccgcaaacac attatcctga 3370861 ttgcggttca gcgtcatttt tccaatgatc ttcaccggca caagctcttc cggccacagc 3370921 ttagttgggt caagaatatc aaaatcaaac ttgaattcat cttcctcatc aatcatctgc 3370981 acgccgagct cgtattcaac cttgccgccg ttttcaattg tttcccacag gtcacggcgg 3371041 tggaaatctg gatctttccc ggcaattttt tgcgcttcat cccatacgag agaatgcacg 3371101 ccgagcaccg gcttccagtg aaatttcacg aaacgtgcct ttccttgttc attgacaaaa 3371161 cggaacgtgt gaacgccgaa gccttccatc attctgtagc tgcgcgggat gcctctgtca 3371221 gacatcgtcc acatcaccat gtgggcagac tcagggttat tggcgacaaa atcccaaaat 3371281 gtatcgtgag cagtcgcagc ctgaggcatt tcattgtgtg gctcaggctt aaacgcgtga 3371341 accaaatccg gaaatttgat tgcgtcctga atgaaaaaca ccggaatgtt atttcccaca 3371401 aggtcatagt ttccttcttc agtataaaat tttgtcgcaa agcctctggc atcccgcacc 3371461 gtgtctgcgg agcctttaga acccgcaacc gtagaaaaac ggacaaatac cggtgtcttc 3371521 accgaagggt cctgaagaaa tttggcccgt gtgtattccg tcattggttc gtaaacctga 3371581 aaaaagccat gcacgccaaa tccgcgcgca tgcacaacgc gctccggaat cctctcatgg 3371641 tcaaagtgcg tcattttctc ccggaaatga aaatcctcca tcagcgtcgg gccgcgaacc 3371701 ccggctttta acgagtgctc atcctctgac actcgcaagc cttggtttgt cgtcattttc 3371761 ttcccgctgt tatcggtcct gtactgctca agctgctcgt cctttgagtg ttcatttaca 3371821 cgtttgtttt ggtcatcact catgtctgct cccccttttt aaaacgaaac attctacagc 3371881 acatttaccc gtggcgttct tcatataaac tgctaatccg ctcattagga tttttggtct 3371941 acatataaat atgcggtcat acacatttga aataagcctt cttcacagaa agaaaggatg 3372001 gaagcgctta ccaaaaaagc tgttgaatag gggaggtcat atcatgcttg ccatactcgg 3372061 ttttgtgatg atgattgtct ttatgtacct tattatgtct aaccggcttt ccgctcttat 3372121 tgctttgatt gtcgttccta ttgtgtttgc cctgatcagc ggatttggca aagatctcgg 3372181 cgagatgatg attcagggcg ttacagacct cgcccctacc ggtatcatgc tgttattcgc 3372241 catcctgtat ttcggcatta tgattgactc aggcctgttt gatcctctca ttgccaaaat 3372301 cttatcgttt gtcaaaggag atccgttaaa aatcgccgta ggcacagcgg ttctgaccat 3372361 gaccatttcg ctggacggag atgggacaac aacctatatg attaccattg cagcgatgct 3372421 gcctctctac aaacggctcg gcatgaaccg tttggtgtta gcgggaatag cgatgcttgg 3372481 ttcgggggtt atgaatatta tcccgtgggg cgggccgact gcgagggttt tggcttcctt 3372541 aaaattggac acgtcagagg tctttacacc gctgattccc gctatgatcg ccggcattct 3372601 ctgggtgatc gccgttgctt atatcctcgg aaagaaagag cggaagcggc tcggcgtcat 3372661 ttcgattgat cacgcaccgt cttccgaccc ggaggccgca ccgctcaagc gtcccgctct 3372721 tcaatggttt aacctgctgc tgactgtcgc tctgatggcc gcactgatca ccagcctgct 3372781 gccgctccct gttcttttta tgactgcgtt cgccgttgcc ttgatggtta actatccaaa 3372841 tgtcaaagag cagcagaaac gaatctcggc gcatgcgggt aatgcgttaa acgttgtctc 3372901 aatggtgttt gctgcgggca tattcacagg cattctctcc ggcacaaaaa tggtggatgc 3372961 catggcgcat tctctcgttt cactcatccc tgatgccatg ggcccgcacc tgccgttgat 3373021 cactgcgatc gtcagcatgc ccttcacctt tttcatgtcg aatgacgcct tttacttcgg 3373081 tgtccttccc atcatcgccg aagccgcttc cgcttacgga atagacgccg ctgaaatcgg 3373141 gagggcctcc ttgctggggc agcctgtgca tctgctcagc ccgcttgtgc cttccaccta 3373201 tctattggta ggaatggcag gcgtcagctt tggcgaccat caaaaattca ctattaaatg 3373261 ggccgtggga acaacgattg tgatgaccat tgcggcgctt ttgattggga ttatttcttt 3373321 ctaaatgtat gagcttgatc gtagcattga gtgagtacgt gatttacaga ggggagaaga 3373381 tcaaatagga tattatgagt gaatagaaga ttcatgccaa caacttctca ttacaatcat 3373441 aagagcctgc tatattgcag caggctcttt cacatttggc attatttttt tgtatagcgc 3373501 acccagtcat aatgagcgta tagcggattt acaccattgt aggagccaag ccattcatcg 3373561 acacccgtgc cattccacaa gttcatcatg atctttccag gtgttgtcgg aatttggttt 3373621 gttgcagtat gttttaattg cccgtcgaca taccatttaa tagagtttgg ctgccaatcg 3373681 aatgcatacg tatgataggc attggctgca tcaaacccga gatcaacaat cttctcatgg 3373741 tttcctgcac catttgtata atagttaaat tgaaccttcg ttgtgtcttt tcctaaaaat 3373801 tcgatatcaa tctcatccca aggagttcca tctgttggac ctgtgtaagt gaagaacgat 3373861 gaaacgatcc ctgtgttttt agctggtttc attctgactt cataaagtcc atagccatat 3373921 gtttgaacag aacggttttc cccgcagtca aacttgttat aagctgggct tgttagcgct 3373981 aaacgcattt cacccaatga cgtcattgat acgttattag cccgccacgt gcagttgaac 3374041 atatttccat tcgaataacc atctgctttt tgccaaaaac cggagttata gccgttaaaa 3374101 gggtcaaaaa acgatccacc tgtttgagct gaggcagtag cagtgactgc aaacaaactc 3374161 ataaacaatc cagtgacaag aagcagcaac actcgtttca gataaggcat attggcattc 3374221 ccctttcatt gaaagcgttt tctatgttga tcttacatga ttcttttaaa agggaacatc 3374281 ggtcaaaata atgataatat cgaatcttac taacttgaat cctgtaacta tcatcatctt 3374341 ccctctgaaa aaaataaaaa cctaaattac catcagcaca gacagagatg atccgcactc 3374401 attgcaattt aggttttgcc tgctttatca gtaacaatcc taccattttc atatgtgaat 3374461 gtaagaaaaa gtgaacacaa ggaaacacaa atgtcagcgc tctcattatg cttgtttaac 3374521 taccctttct atgtgaatgg ttaaatacag cagctcgtca cttgtgagct tgtgctcata 3374581 ctcccgctca atgtaggttt ggattttctt cgtgcattca tacgcgcgat gatacttttc 3374641 tttcactgta tccagcaaaa aatcgtcctg gctttccatg tgagtgccgt taaatagacg 3374701 ctgcgcgaaa aactttaagt gggtgacgaa ccgataatag tgaagcgatt cttcgttgaa 3374761 ttcaatctta aaatggtatt ttacaatact caaaatctct tgcatgactt ttgtaatgtt 3374821 gataatattg ggcatctctt cattcagctc ggcatttaca atatgcagag caataaagcc 3374881 tgcttcatcc tctggcagag acacaccagt cttgtttttt accataacca acgcttcttt 3374941 gccgatcgca aattcgtctt tgtagagccg ttttgtttcc cacagcaagg cgtttttgat 3375001 atcaagccct ttctggttgc gctggatggc aaagttaata tggtcggtca gcgacacata 3375061 gatgctgtcg ttgagctttt tgccgagctg taattttgcg tagctgataa tctcttcgga 3375121 tacttccata cactcgatcg gtatatcata caaaagggtt ttgaactttt ctgatacatc 3375181 cttgttatcg agcgtgaaca ctttctcaat gcgggcttca tcgacatcat cgccggactt 3375241 tttctgaaac gcgagccccc tgcccatgac gaccaattct ttcccctgtt cattgaccac 3375301 gctgatcaca ttattgttga tcaccttcgc aattttcatg gcatgtccct ccaaatctac 3375361 taagaacaga ctatatcttg attgtacatt ctttttgtac taggtcaata tcatcaggga 3375421 aagacggaag ctggtcagta caattcactc cgtacctgct gcccgggctg tttttgaagc 3375481 agcgcctcca gatggcgttc aaatgatgcc ttgtcagctt tctgcttttt gacaatgctg 3375541 ttcatgattt taatgctttc agcactgtat tgtgtatatt gttttttcag ctgatccagc 3375601 tgctgtcttg tcttcttcgc gtttttcggt gtgacttggt tgatgagttt gatcatactg 3375661 tctgcggtct caaaaaaacc ggctctattt tctgtcagct gctgaatttc gatgcggctc 3375721 atatcttgat tacgcgtttt ttgaagcaag gcaaccgcct cgctgttttg ttttttgagc 3375781 gatttgttct caagcttaat cgattcgaga ttctccttcg caatgtctgc ttcttcttca 3375841 gtcatgctga ttcgcacgaa gtattctgga ttgccgattc cataatcaaa tgcttcgctc 3375901 acttgtatca tggaactgaa cacaatggcc agctgcctgt cgcttgcgag ggcttggaaa 3375961 tcctgctttt tcttactgct catcggtttg gctgcggttt gttttactgt cttttgatca 3376021 cagtctgcga acatctgagc ctcaccttca ctttcgcatg cgctcatcac aagaactgtg 3376081 accagcaggc ttatacacaa gcctattcgc ctcatgctct gtctcctctc tgctgaatcc 3376141 cttctggaaa ataccataaa atatagttaa atggtaccag atgcacctaa ccccagcaat 3376201 aaatcaaaag tatgatttga agcgaaaaaa cataaatatt ttgtaaaaat tgacgtgcat 3376261 tccattcttt tcaggcccat ttctcgtaca atagaagtat cgttaccgga gaggggctct 3376321 gatgatgaaa cgttttacga aacaagaaaa cagctgggtg ttatatgact gggcaaattc 3376381 agcttactca attgtcgtga ccaccgcggt atttccgtta ttttataaat cagcagctgc 3376441 ggaaagcggt gtcagcgccg ctcaatcgac tgcctatctg ggctatacca ttgcgatttc 3376501 aacgtttatt cttgcgatgc tcggccctat tttaggcaca atcgccgact atgaagggtg 3376561 caagaaaaag ttcttcggtt tctttgtgtc agccggtgtc gccagcaccg cgatgctcgc 3376621 ctttatccct agtgaacatt ggctgctatt gttgctgttt tatacggtat cggctatcgg 3376681 tttttccggc gccaatgtgt tttatgatgc ctttctcgtg gacgtcacgc ctgagaagcg 3376741 gatgaatctc gtctcggcac ggggttttgg cttaggatac attggaagca cgattccatt 3376801 tatcatcagt attgctgtca tcctgctcgc acaagcagag actattccag tgtctgtatc 3376861 ggccgcaagc cagctgtcct tcttcataac ggctgcctgg tgggggctgt tcaccatccc 3376921 aatgattaaa catgtccatc aacgctatta catcaaaaaa gaacctcata ttgtcatcaa 3376981 cagctttaag cggctcggcc aaacgatgaa acggatcagg caataccggg cacttttcct 3377041 cttcttgctc gcttatttct tttatatcga cggagtcggc acgattatta cgatgtcgac 3377101 atcctatgga tcagatttag ggatcggctc ctcaagcctt ctgatcatcc tatttgtcac 3377161 ccaggtagtc gccgcgccgt tttcgattat atacggaaaa ctggcagaac gcttcacggg 3377221 gaagaccatg ctgtacgtcg ggatcgtcat ttatatgatc gtctgcgtgt atgcctattt 3377281 tatggagaca acgcttgatt tctggatact ggctatgctt gtcgccacct cgcaaggcgg 3377341 tattcaagcc ctaagccgtt cctatttcgc caagcttgtg ccaaagcgcc acgccaatga 3377401 attctttggc ttctacaaca tttttggaaa attcgcctca attatggggc cgctgctcat 3377461 tgccgttacc gcccagctga ccggtaaatc ctcgactgcg gtgttcagcc tgatcatttt 3377521 gtttgtgatt ggtattgtga ttcttgcctt tgttcccgag gaaaccagca cagatgtcag 3377581 ccagcagcaa aatgacctgc ccctttaact gggagcaggt cattcatcat ttattcgctt 3377641 tattcacctt cagctgtttc cctttgacgg ttgtgttctt catcactttg agaacatgag 3377701 ggcctttacc atttaaaatc tcaacgtatg aggcgttatc catgatcgtg atgatgccga 3377761 tgtcgtcagc tgacacaccg tcaattttgg caatcgttcc tacaaaatca acggctctga 3377821 ttttcttttt ctttccgccg ttaaaataca gcttcataat gtctttattc agctcttcgc 3377881 ttttgtcctt tttgctttcc ggacggtcat tcagtttagc tagaaattct ggtttcttcc 3377941 ttgccacttc ctcttgagaa ggtgcttcta ttttttggat ttcaaatccg atatattctt 3378001 caatgtcggc taaaaaccgt ttttcgaagg ccgtgacaaa cgaaatggcc tttcctttgt 3378061 tccctgcgcg tcccgttcgg cccgtgcggt ggacatagct ttctttttca agcggcagat 3378121 catagttgat gacaagggag atattttcaa tatcaatccc gcgcgcggcg acatccgtcg 3378181 ccactaagta acggtactcg ccacgtttaa attcattcat gacgtcgaat cggtcttcct 3378241 gaatcattcc gccgtgaatt ttatcgcatg gatatcccaa gtcatccaat tcatcggtca 3378301 gctgattgac gtgctccttc gttcggcaga aaatgatgca gctgtcggga ttctccgtca 3378361 tcagcacatc tttcagcaat gaaaacttat tctcttctct tacttgaatc accgcatgtt 3378421 caatatttct tgtggttagg ccggccgctt tgacctcgat atgctcgggg ttttgcatat 3378481 attgacggct cagcttctcg atatcctgcg gaagcgtcgc tgaaaacagc atcgtcgtac 3378541 gctcagtcgg cagatgcttg ataatcgcct ccacctgctc aatgaagccc atattcagca 3378601 tctcatccgc ttcatcaatg accaaataag agagacgatc caacggcagc gtgccttttt 3378661 cgatatgatc cagaacacgt cccggcgtgc cgacaacaat gtggcttttt tgcttaagct 3378721 cagctttttg tttatcaaag gaggattttc caaatacggc tgtcgctttg atccgtttaa 3378781 atcgtccgat gttcgtgata tcttccttta cttgcaccgc aagctcacgg gtcggtgtta 3378841 aaataagcgc ctgcggcttg ttttcatccc aattcgccag ctcacagaga ggaatcccga 3378901 acgaagccgt tttcccgctt cctgtctgtg atttgacgac aagatccttt cgttcaaggg 3378961 cagcggggat cacactctgc tgcaccttgg tcggttctgt atatcccagt ccttccaatg 3379021 ctcgtaaaat gtcatgactg atttgatagt ttttaaaatg actcatgtat aaactcctgt 3379081 ctcttgcaga tgttctcatt atactctaat tgaccaaggc atatgtgttt tgtcgaaaaa 3379141 tgatgtatta aaagccagcg attccctggc gttttagctc ctgaacagcc aatcgcgcca 3379201 gtgcgtcggc ccccgcgcga ttcgggtgca gcgtatctcc atccatataa agcccgagtg 3379261 ttctttccgg accgatcgat gtaaagtatg ccgagctgag gacatttaag tcaatgagat 3379321 atgttttttc ctcttcggcc aaagctaaaa tagaggccct gtaccatctg tttacagacg 3379381 aatggatgcc ttcagaagta aaatcggttg cccggccctg aggcgttgat aggatgacgt 3379441 ccgctccttt cgcttttacc tgacgaatca tatcacgcat cacctcttta aactccgctt 3379501 cagattcttt atgcttcgga tttgtgtcat taatgccaag ctgcaacata aaataatctc 3379561 cgggtttaat atacttcaga atcgcctcaa gctgtccatc atttctgaac cctctcgcga 3379621 tctgcccgcc agacgccatg tttctcactt gaaaggtgtg tttatcgata tagtgaggca 3379681 gcatctgccc ccagcccgcc tgcttgctgc tgttgagcgg ataataattg cacaccgtcg 3379741 agtcgccgcc gacataaatg gttcgattcg ttaccggctg atcagacaat ttctttattt 3379801 tcaaggcgct gagcgtaaaa gcggtgcctg cctttccctc tgtcaccagc agattcagct 3379861 gcccgtcggt gacgggaatt tggaacgtat cctccgcgcc atcccctgtc atattgatga 3379921 cctgaaacac gccctccgct gccacactgg cccttgccgt attgccaagc gtcaccttca 3379981 cctcataaag gccattcggg agatcaacat taaacgtgtt attgcttttc gtcccatacg 3380041 ctaaaaactg aaccgcatca ctcttcacac cagccccgga tgccgccaca tccctcatat 3380101 tctccggtgt ttgaaaaccg tagccctttg accggtcata ccgatcagac gccctgacac 3380161 caatataacc aggctccatc gaaccgcttc caaagtcaaa ctgatacacc ttcggctccg 3380221 ccgccttcac attctcaatc ccgccaaaac acagcatcag catcatcaca aaaaccgctg 3380281 ccatccattt tttcatcaag actccccctc tatgaaaacg aatacattaa tgcatactcg 3380341 gtgattgttt ctttatgatg actgaattaa gaaaaaaatt gcgttgagga ataaaaatga 3380401 ggggagagtc tcaagaaggg gaaaatcagt gtgacttctt gtcacacttg atcacatccc 3380461 aacctccgca atagaagctt atttggtttt cttcgtcata cacataataa cggagtcttt 3380521 cccattgatc gtcagtcggt acaatctcca atgcaaccga atcgatggat tcaaggtcat 3380581 ccagctttga tgcactaatg ttttcaaacc gcaattgaat gtcacaggtt tgagcagatc 3380641 gttttcattc aaacacagga atatgaatat aacgatcatc ttctttcata tagaaagaaa 3380701 actcgtttaa tgtaaatgga cctgtatcct catcagaaag atgctgtttc aatttctcgt 3380761 attgtgtgat attcaaatga attccctcta tttatatgat tcaccgccaa tcatataaat 3380821 gtccacagca tcgtattcaa accatatgat ccgttcgcct gagtccgtta ggcattggag 3380881 cttcccttct gaaaaatagc ttttatccgg ttgaggatca gtgatcagaa aaacatcatc 3380941 attgatggaa gctagcagaa agagaaaatc tgcaatatcc cggtctgctt cctgtaatat 3381001 ggattggaaa tggaattccc ttttggccag cttcgtcacc ttgtaagcat gaccttcaaa 3381061 atactcggac aggtcttcta taaatgaacc agtcgttatt acctgtatca tgattcgatc 3381121 gtaggcaagc cctgcccaaa aacgataaaa cgactctgca tcttcaagtt cgcatgccat 3381181 aacggtttgg tcaggcttaa gctcgatcat gtccaaattg ccaatactgc ttatagaggt 3381241 tatttccata aaatcttccc cttatcagtt ggatagcgca acgcaaatct cttgtctgac 3381301 ttgttcatac aagagaatgt gatgatacag atccttatcg tttttgatca tatccggaag 3381361 tatgtcagga tacagctcaa aaaagctttt ctccaacgaa cgccgctgat gccggggtat 3381421 ccttttattc gccagcacat aatccaaact gccagcaaca agcataaaaa actcatagat 3381481 ttccgcttca aagccgtaca attcatcagg gtactgcttt tcttcaagct ctcgctgtct 3381541 ttttctcagt ttttgaagca cgttgatcct ctcccttccg caataatctc atttatttcg 3381601 aaacagaata ggcggatcat tatctatcgc ctccaacagc tcttcaccaa acacagtgat 3381661 tgcacatttc cacgggtctc ccaaaagtcc ccaggagaag tcctgatgaa aaaagaaata 3381721 atagtctcca tttggaaata cgggaacagg ccattcgcca aattcatcct taggcattgc 3381781 ctgatgagga ctaaaggtat atccgtcatg ctgccaatct agtgcgtaca ttacatcgtt 3381841 ctttccagta cctaattgaa atgcttttaa aatagaagtc tctaaatcac ttagcactcc 3381901 gctcacatca ttatgaccag ctttactgct catcgcgctt gagatatcaa acactcgata 3381961 tggatcaggc gggatgatgt gatgacatct gcttccgggc ttccatttta tgatcttgtt 3382021 cacttctgac cagatgcggt cttgttttgt ctgacttaaa gcgcgccaat tcatcataat 3382081 ctcatcccta caccttattg gatatcctgc ttataaacac cagaagaggc cactgcgtaa 3382141 acagcgtaac ttgtcagttt cagctgttga acatctaggc cttcaccgtt cgaatcacag 3382201 catgttatct cttccatctc ttgactcaca tcggcagaaa tcaaataaag agacgactta 3382261 aggtctgcac tgtaacaatt gaacgtccca accaaaaaac cttcttcgga tatcgcgagc 3382321 tgatcaaatg cttctgagtc cggctcttta tccgacagaa tccacacccg tctcacgacc 3382381 gtttcatcaa atgcggcaat gactgcatct ccgtaataca gcatataaat caagccgttt 3382441 ttttctgcaa gtccataaca atcatctaca gcaggcgcat ccatttcttc aagctttcta 3382501 tcaatgtgta tttccttctg ctgaccatct aacgtaaaac accacacact atggccgttg 3382561 ggattctcat catgataaat cccttcatca cataaaccga cccaaagctg ttgtttctaa 3382621 tccaaaagac agcaggaaac ccctgaaggc aagtgaaaaa cacttttcac ccttccctct 3382681 tctgaaaaaa cctttacctt cggctcgtac gattcgtaat aaacgaagac atagccatct 3382741 gcacattgtt gaaagagcag aatatcactg tatgaaatct gctctttcac tctaaaatcc 3382801 cgaacatcac cggaaggatc atagattgta atggtgatac cacctttcaa cccttttcca 3382861 atgtagacac gcccctgtgg atcagcatgg aaaaaacaat cttgggtgtt ctcgttgatg 3382921 attttattca attttaattt tttcattggt tatgctccta ggttcgaaat gaaatgataa 3382981 gaataaacca tttattagct attagtaacg gacaacctag tttcattaat cgttttggga 3383041 taaatctact ttccaattca gccttaaatc atttagtgtt taattggtat gcataaaacg 3383101 attgatcatc aaagcgaact gtttcagctt ctatagcaat cagcattctg ttcatgtcaa 3383161 taagaaagtt agcatttgat tgatactccg gaattataga atttgataga ttcccgattc 3383221 cttctggatg ataactcatc tcaaatactt gccaattgta ttcttccgga tctatttttt 3383281 ccaatctcat gtcgccaaca tctgcactat aataagcgga tgccacattt tgaaatgaaa 3383341 ttttatgcgt atattcacct tcatcttcaa aaaccttaat atcaagtgag agttcttttt 3383401 taaacacatt aaaatctaaa tgaaggacac tgcacccctt atctatataa tcaacccatt 3383461 cattaatcgt ttgatacatt gtcatcccct gcctcttttt aaacaataac gccttgccac 3383521 caagcagaaa acaaattact ccgtatattg tttgatccaa tcatttaaat catctgttga 3383581 atgcaaataa gtttctgatg aatctttcaa atcaatccca cttagaagga ttaacatatc 3383641 ccagactcta tcgtcttcta cttcggggtc atccgcataa acataagttc cagcccaatc 3383701 cgacacttct tctcttgttg tttgtccatt taagacactt ttgattttat ttatgcattc 3383761 tattagattt gtctcgctca atttgatcac cacgtattca agtactaaat gattttttat 3383821 tagtatgcaa agcaccgtac tgatatttag atattgaagc tttttccgta aaagatatgt 3383881 tccaaaaggt ttccaatcta ccaataaaca agctcacatc cgtattccgt gtgcaatata 3383941 cataaaccaa actggcactt aggctcaacc aaaataaaac tatgattgag aatcccttca 3384001 tcgaactcaa tacactccaa taagcagtca aggtgctcga gacattttcc aaaagaacaa 3384061 actaacgcac caatttcgct gctgtattga tgaaacagca gaacgtcccg gtcatcgtaa 3384121 gcaacatatg actgagatat tttccagatc agctgtttcg cttccgtttt ttcgagggca 3384181 tcaacctcac gggtgttggc tggtattgaa tttgataaaa ccagctcaag caattgcctg 3384241 ctttgcgcca gatcagcaaa acgataagtg aagcctcttt ctgcacaagg gactagtttt 3384301 tctttgattt cgctcatcaa taaacgtctt ttattctcgg cgagtttttc gatcaatctt 3384361 ttttgcatga gccgcattcc ctccgctgtc aatttctcaa cttcttttaa attgattcat 3384421 cattctcttg ttttcgttgt cgttcatgtt tagatttgtt ctaaaaaagc ttgtatcgct 3384481 tatcgataca agctttatct tcaactgctt aaaactcacc cagtgggctt ttcacaaaac 3384541 gctgggaacc tttttggcaa atcctcttca tcccaatcaa ttctatattt ttagattctt 3384601 ttgtcataca aataagagag gatggtaaca tctcttattt aatgttccat caataaatgc 3384661 cccattttta tccaatgcag aaattattta taattaagga agtttagaag gattttttgt 3384721 attttcaaga tttaatttta aagcggtcac aaaagactct agcttttctt cattacaatt 3384781 aatttcgaac aagttggagt tcgacttact ttctttataa tcatcaaata taattttaat 3384841 cttaattctg taatttccgt tttcttgatc aatactaaga aataagaatg gttcaatagt 3384901 ctctaaactg atactgtctt gatttccttt tatcatagtt tcgatcccag atatcaacac 3384961 cttatattca ctttctaata aaacagcaga aaaatcgcga acgacggctt tcttattttc 3385021 caacaattca aatacagata aaataaatgg atcatcgtcc aactcttgat accttctcgg 3385081 tgttaattca agttctatac aatcatcttt tattttggcc atatttcctc ctcatttaaa 3385141 gtttaagtga gggtagttgt catccccccc tcgcttaacc ttattaacgc cttctcttag 3385201 atttatttcc ttttccgtgt gtatggaata cgtgtttaga acccttagct cttgaacttc 3385261 cataagctgt gattacttta ccccttttat ttaaaacaac tgtagctttt tttccaacat 3385321 atttcgttgc cccattaggt tgttttatta cttttttagg gcttcgcaca gcattcagtt 3385381 tggcccttaa attgactcca cggcctccat ttcttcctat agattgatta agtccatgtc 3385441 ttgtatgacc tgtgatttta actgccttct tcgtaaactt ataggcgcga ctagcaccct 3385501 taaatatctt cccaggacca aaattagaag cagctgccca agcagcacct ttccatcctt 3385561 tacctgattt atatgcctta tatccatcat aggctgcaaa tccggcattt accacaagcc 3385621 atacccaatg cccgtccgga tcaacattca tcactgggtt attatttcca taagcatacc 3385681 cattctgatc caatgaatct ccgtcgctgc ccgggtctgg gtcgagcgat aggaacacgc 3385741 cgtttcttgg ctcgtagtag cgggccatga gatagtacag gccggtttct tcgtcgtatt 3385801 ggtagcctgc gtagcggtag cgattgtctt ttacttcgtc gcttgcttcg gtttttgttg 3385861 gatttcccca tgcgtcgtat tgatacttgg caacggtttt tccagtgctg tctgagatcg 3385921 cgatgatgtc gccgtgagcg ttgtagtgat agaaatattt cttaccattt tctgtgtagg 3385981 ataacagctg gccgctgtct ccgtacgtgt atgattttgt gacgttgttg tccgcgtctg 3386041 tttcatacaa gacgttcaag ctgtctccgt cgtagaagta gttcgtgact tttccgttga 3386101 cggttttttg gattctgttt cctttttcgt catacttata tgttgcgaat ggcttgtctt 3386161 cgcctttttt ggtaacggcg gtcaggttat cttctgcatc ccacgtatat gtgaatttgc 3386221 cgtcggatgt gcggttgccg tttttatcgt aagagatgct ttcatcattg acttttgtca 3386281 gctggttcat gatgttgaag gaagcgttca ccgttttgct tgagccgtct tttatagttg 3386341 taacggtttt ccggtttccg aatccatcat atgtgtattc aataacagta ccgtcttcat 3386401 gggtttcttt gacaagctga ttcagcttcc catactcata ttgcaccttg ccgcttgctg 3386461 agctgtttat cgttgtgcgg ttgccgttgg catcatattc atagctttcc gtcagaatgt 3386521 ctccgccgtt tttgtcaccg atatgcagcg agcttacaag gtttctttcg tcatatgaaa 3386581 aacttgttcc gccgccgttg cccgtaataa aggtttggac gtttccattt tcatcataat 3386641 caaatgaata tgaggatgta ctgtctttca tctcaatcat ttgatccagc ttgttatacg 3386701 taaattgatt cgttcctttt tggtccccat gaatccacga gaaggttttc agcttatcgg 3386761 agtcactagg atatgtccaa gtttggctgc cgccgcggtc tgtcagttcg gttaaacggt 3386821 ttttgttgtc aaatgtccgt ttctttgtgg tgttctgctc tttattgacg accgacgttt 3386881 catttccatt tttgtcatac gtgaaaatgt acttttctgt accgttatac gactttgatt 3386941 tcacccggtc tgttccatca taagaaagag acacttcgtt gccatttggt gaaatggttt 3387001 tggtcaggtt gctgttggca tcatattcgc ttgctaacac attgccgaga gggtcagttg 3387061 ttttgacaag cttgcccatg acatcatatt cgaatttata ggtttgatct gctcctgccc 3387121 ggatggtttt gcttacctca ttgccttcct tatcatagct gtgaaggata gacgtgccgt 3387181 tagagagcgt catgtttgtc aattggtctg cctgatcata cgtataggtt gttttttcac 3387241 cttttgcatc tgtttcagac gttttcttac cagtttcatc gtaatcagtt gaagtggcgt 3387301 aacctagttc gtcctcttcc ttggtcacat agttgccatt actgtcatac gtgcttttag 3387361 tcagaaggct tccttcaatc aaacggatat catcaaacca gactgtgcct gtcgcactct 3387421 tttggaacag aatactgata tcgactttat tgatcggctt tgttttaggg atgacgacag 3387481 ctgctcggtt ccattcctgt gttccagaag ggaatttcgc attgtagatg cctgtgctgc 3387541 cgtcagcgta agtgacattc gcctgcagag aatagtcttt ttcatctgta aatttgacgc 3387601 tgcttgcttt cgacattcct gtcagtgtga gataaaccgg tttgtcattt gcgctttgcc 3387661 ctaagacaac ggtttgtttt gttactgatc cggcttggga cgcactggtc cgggcagctt 3387721 ttaatgatac atcatcatta aagccttctt cagaatcaac ggatgctccg cttacattcc 3387781 agttttccgt tgctgatgtg aagctgctgt tttgaactgg gttatagctt gatgatactt 3387841 cgcctttttc cagctggact tcatcaaacc atgcttttcc tttgccatct ttatctttat 3387901 gatcgacttc catatacaca acagctttgc ctgcattcgc tggagtcgta aaagtgattt 3387961 gccgttttgt ccagtcattt tttccggcta atgcactgta ttcattgtga atccattgaa 3388021 ttcgtttttg atctttgtct cgcaaatcaa tgttaaaata ggctcttgat ttcgcaagat 3388081 ctgttttgat tttcccgctt aatgtatagg ttgtattcgg ctccagctca actgtttgtg 3388141 ttgctgacga atacccatga tctgttccgg cagacgttga ttggctcaag acctccaatg 3388201 cctttgatcc ggaaagaact ccgcttttat cggcgatgac tgaaattttg ccgctgtctt 3388261 tagaggcagt cagattccag ccggattttt gagcttcaaa gcttccatct ttcaaaatat 3388321 tagttgaagc tgataaatct ttgctcgatt gaatctggtt tccatattta tcataaacag 3388381 ctgctgacga tgattttccg ctctgatcgg tttcggatac agcatccagt ccgtcataag 3388441 caatatccgt gacattgccc tcggtatcct tcatctttgt gacatcgttg tttttgttgt 3388501 attcgtatgt ctcagttcca tatgcatctt taaccgacgt aacgttgcca tctttgtcat 3388561 attgatagct ttccgttgct tttccggtgc cgacgtcatt tggatctaca tcttctacaa 3388621 cattgttgcc ttcatacttt gtattcgttg taatttttaa cccttccgca tcatcaatga 3388681 cctgaatcgg atttcccgct tcattatagc catactgtac tttccggcca tttggctgtg 3388741 tcatgagaag cgtcttttta tcagcatcat agctgtagac atatgtttct tttttagcgt 3388801 tgatcgcttt ttcgagacgg tgaccgctat actgatattc ggtaaagaca ggctttgctt 3388861 cggtactgtt agctgaatat tgtttgacaa ggcgcccttc actatcgtag tcatagcttg 3388921 tgacagtccc gtctgtatct gtaaccttct tcagcaaatc attctcatat gagtaggtga 3388981 ctttcttatt cttaggtcct gtgatggacg tcacatggcc gttttcatca taggtaaatg 3389041 taagcttgcg gcctgatgca tctgtaatgg cggtcagttg atttttgtca ttgtaagtat 3389101 agacagttgc attgttatgg ccatccacta ccttttggag tttgccgcct tttttattga 3389161 aataagcgtt ggtttgatcc tttgttttta atatgaactg atcagctgtt tctgttaatt 3389221 caagatatac accggtcggc ggctgatacg tgccatcggc ttttttcgtg aatcgatgtg 3389281 tcgtagcgtc ttcatcgata tacattgccc cgccatccgt tgagatgaca gatgtttctg 3389341 catcagcata ccagccttgt ccaaataagt gatcagagct gtcaagactg ttgtaggttc 3389401 tcgataagcc aagtcccgga ccgcgtccat caattgacaa atcttcttca ttcacaatga 3389461 cattgcctgt cgcaccattt aactggccgc ttgggatatc aatgatagac cagtactctt 3389521 ctgtacctag gaattctgcg ccttcatgga acgttgggtt aaagggcgcc gttggaatcg 3389581 tttcaccatt cgcatcatag gcgacaagcg tgaaagaata attcttcttc cctttgtaat 3389641 tcccatttgc attgttatag acaggtgatg gatcgagggc taattccccg ccttttccat 3389701 ctgtatgaag cttatagctt ccggctttga tttcctcaga agtcggccag atgtttttat 3389761 tttgggttgt ccaatgatca gcatcaccaa catcaaagga ctgatattct ttaccgttgt 3389821 aaatgttaac tttatagccc ttcgcatttt gaaccttttc ccatatcaaa ttcacataac 3389881 ccgtttgact cgattttgta tttgtataca aatagccagt tacattcttt ggcctagcga 3389941 tatcaggaag tgccggggta gcagccgggg atgcaatggc ttcgccgtct ttgttgtatg 3390001 cgataatttt aaacgagtaa tttcttttgg ctccatctcc cccggcgttt ttataggttg 3390061 gtccgggatt gatcggcagc tctgctccgc ttccgtcctt taggtgaaga gcatattttc 3390121 ccgccttgat ttctgcactt gtcggccaga tctttttccc ttttgtggtc caagacgtct 3390181 gatttccgag atcaagtgtc tcaaagcctt tcccattgaa cacctgaacc ttatagccgg 3390241 ttgcaccgga tacagctttc caagaaaggt cgaagtatcc tgtggcattc ccattattgt 3390301 agccctttgc tgacggtgct tgtgcttttc ctacattagg gataacgggc tttgccggtg 3390361 cggacatcgc tccttcacct tggtcaaata tcgcactgac gccaatccaa tagtttttgc 3390421 ttgtagcata gcttccgccg gaattcttat agaccgggga tggatctaat gccaattcag 3390481 ctccatcctt gccgtccaga tgcagtttat atctcttgga ggcaatttct gcgctcgtag 3390541 gccagatttt tttacctttt gtgctccacg acgtgacgtt gcctgcagaa atcgcttgat 3390601 attccttacc attgtaaatc cataccttat atccttttgc gccttcaacc tttttccagc 3390661 tgatatcgaa ataaccagtg gaatcgccgt tgtgataggc tttgattgta ggtgtgtttc 3390721 cctttggaat ggtatacgtc acttcaatat atggtttatt ggcggagttc gctgaagaaa 3390781 ttagtttttt ccaatattcc ttgccgtttc cgtttgtatg aagcttaaat ccatagttgg 3390841 ccccgccgga gttccatgac tttacagcag cggtcacatc ataactcgcc cactgtcctt 3390901 tatggacgtc ggcttttccg atatttttag atgccggttt ggtgttccat gtcacttttg 3390961 cattatcata attgctgttg accgtatcca gccaaaggcc ggttgccttt gttccataat 3391021 aggaatgggc tacgtatgtt tttaatgtag ctttagtgac agtcatattt tgaattggct 3391081 ttaggttgtt aaatttcatg aacgcatagt ttgtgcctgt tgttttgtca taatagcccg 3391141 ttttcagtac ataggccttt aaattagcat cccatttttg tgaggaggcc gaatagttcg 3391201 tcgtcgggta ggcactcatg acaaacgtat ccgatgaaac agataaagaa gttgacgggt 3391261 cgatagatac tggatatacg cgttctgggt ctttcagcca gttctcgtct gccgtaagat 3391321 gaagcaaata cccttcttca ttcttttcca gcttatagct gactttgtct gaccgttcaa 3391381 cctcgccgga aagctcatct agttttgaat ccgtcataaa aggcttaggc acagaaaaaa 3391441 caacttttcc tttttcatca gaaaaatcaa tggatccatc ctcttgttct ttagcctgca 3391501 aatcggtttt taactgaaat gtaaatgtgt tgtatccatt atactgatga aggactaaat 3391561 cttcttttat gttttcattg aatgtgaaag tctgaagatc aatattcgga aacacatccg 3391621 gatacacaat ctcattactg tcagtcttat aatctgctga ggtatctttc ggagtaagtg 3391681 aagttttatt cgggcctttc gcttctgcta gtgaatatgt aaccttatgg tcattatgct 3391741 caaaagtcgc ataaagcccg ttcttcattt gcttttgaaa atctgaattc aaaatagcgt 3391801 tctctgtctc gacttgtttg cttgtcgact cttttaactc aggagaaatg tcttcccagt 3391861 cggcatccgg tgtttccttt gtatgaatag gatcaaggta tacttcctgt ttatagacac 3391921 cgtcaccttc ataatagagt tttgtatttt ctgttctttc agaggtgatc tcaccctctt 3391981 tgtttatatc ttttggatca aaaggtacag cttcctcagt ttgttctttc tgaagagttt 3392041 cttctggatc atcggcagca atacggtttc cattctcttc ttctgtagat tttgctagta 3392101 catcggctgg cactaatgaa atcattaaag ccaacactaa aaatgctgca atgaaccttt 3392161 taaagtttcg cctctttctt tttttcattt cctctctcct tttgtaataa aagtaatatt 3392221 tactcaataa tcttaactag actgaaatat cattacaata tttttctaga aaatttatct 3392281 tattttaagg attagcgaga gtcaattgac ctaaaacaaa aaaaggccgc ataggccttt 3392341 ttacattttt tattgtattt gttcaatatc cgtaccctca gctgtcacat tcgccttccc 3392401 ctgcctcctg acaagcgtca aggccatgcc cgcaaagatc attacgatgc caagcgtttg 3392461 atagaggtca gggcggaagc ctgtgaagac ggtatcgagc acgatcgcga cagcggggtc 3392521 gagaaataca atgattgaaa taaatttcgt tgataaaaat cgtaaactgt caaaaaacag 3392581 caaatataca atacccgtat ggatgatgcc ggtagatacc accataatcc agtttccctg 3392641 agataggtcc gcaaaagcgc caaagtgaat aaacggaatc aggatgataa cccctaaacc 3392701 tgtctgcaag aaggtggtcg tgtaaggact gagattgtga atgccttttc ccaataaagt 3392761 ggtgaacgca taaaacagtg cggcgagaac tgcccatatg atccctgatc ccatcagctg 3392821 tgtcaatgat gtgctgccgt taatcccgga aatcagcgca gtcccaagaa agcagatgat 3392881 aatggagctg acggagatca catttaattt ctctctgtag aagaagctcc ccagaagaag 3392941 aacaagcacc ggcgctagat gataaacaga gatggcaatt gtaacggacg tttcttcaaa 3393001 agacttaaat aagaacaccc agttgaatac aagaaagaaa ccgcacgcca atgtttgcag 3393061 cacgtctctc ttgctccatt tttcagtttt atactggccg gacgccagcc agcaaaagcc 3393121 taaaaacagc gtcgcgcaaa ggcagcggac aaagaccaat tcaaatgacg gcagattggt 3393181 atgctctgag aaaaagccga tggagccgaa aatcaccata gagatgacca ttttgattac 3393241 ggctgttgat ttttgttttg acgatatgga aggatcctgt tgcatcaaac gtattctacc 3393301 tccaatactg catagcataa actgtttttt gtgaattcag aaatctacac atagaattcc 3393361 tcttttttac atgtagatat tataacactt ctattctaaa taaaaaaaag cgcccaaggg 3393421 cgcttttttt acaaatctat cgaacaatca aaaccgggca tgttgataat tgagacactt 3393481 tatggctgac gcttccaagc atcatttctt tcaggccgct gatcccccgg ctgccaacta 3393541 caatcaggct gacgcctttc tcttttgcgt gatttagtat ctcatgcgcc ggctcgccat 3393601 tcgcgtaaat ggtttcagct tgaacgcctt tttcggctgc tttttctttt gcattctcaa 3393661 ggattttcag gccctctttt ttaacctcgt tcctgatttc atcaataaag tgttcaggca 3393721 catagacaat tcccgtcaga gaagaagtcg tgacgacggc ttctctcccc acatgaagaa 3393781 tgcttagttc cgcttgttgc tcttttgcca aatgcactgc ggcatcaagc gcttttgcac 3393841 tcatgtctga tccgtcaatc gctactaaca ttttgttaaa catgctcttc ccgcctttcg 3393901 gactgtgggt ggttcatctt tctcttttat tgtccgcctg catttcgtta ttgtcaattg 3393961 aagcgcatga gttttcaaaa aattgtcaga gactctctcc gtttgtggcg ataacctgct 3394021 gataccagtt gaagcttttt ttcttgatgc ggttaaatgt tccatttcct tcattgtccc 3394081 ggtctacata aatgaagccg tagcgctttt tcatttccgc agtagatgcg ctgacaaggt 3394141 caattggccc ccatgatgtg tatccgatta attcaacgcc gtccgcaatg gcttcgcgcg 3394201 cttcaattaa atgatcacgc agatagttga ttctgtaatc gtcctgaatc gtgccgtcct 3394261 cttcaacctt gtctacagcg ccaaggccgt tttcaacgat gaacagcggc ttctggtaac 3394321 ggtcgtataa ggtgttgagc gtgatgcgca agcctttcgg atcaatctgc cagccccatt 3394381 ctgatgattt gaggtaaggg tttttgactc cgcccagcag gttgccccct gattttgcaa 3394441 gctcttccgg atctgtgctc gccgccatcg acatgtagta gctaaatcca atataatcca 3394501 ccgtatgttc tttcaagagc tcttcatcgc cttcagccat ttcaatttca atattgtttt 3394561 ctgccagata gcgtttcata tatcccgggt atgcgcctct tgcctgaaca tctgagaaga 3394621 aaagtgtttt gcgctcattc tccattgccg cgaagacatc ctccggctta gaagtcatcg 3394681 gataggttgt cgttgccgct atcatacagc cgattttcga atcaggaatg atgtcgtgac 3394741 ccgctttgac agcaagagca ctggccacaa attggtggtg tgccgcctgg tacatcgcgt 3394801 ttaatttgtt ttctccttct tcaaaaacaa gaccgcctcc ggtaaatggc gcatggagca 3394861 ctacgttaat ttcattaaac gtcatccaat acttcacttt gtgttgatag cgtttgaaaa 3394921 ccgttttggc atagcgttca taaaactcta tgactttgcg attcttccag ccgccataat 3394981 ttttcactaa accgagcggc atctcataat gagagatggt tacgacaggc tcaatatgat 3395041 gctttaacag ctcatcaaac agatcatcat aaaatctgag gccttcttca ttgggctcct 3395101 cttcatcgcc attcggaaaa attctcgtcc acgcaatcga tgtgcggaac gccttaaatc 3395161 ccatttctgc aaataaggcg atatcctctt tataacgatg ataaaagtca atcccgttgt 3395221 gatacagatt caaggaagtc attgattcat caaatggaga catgatcccg ttcggcgata 3395281 cgtcagctgt cgaaagcccc ttaccaccct cgttataagc accctccact tggttggcag 3395341 caactgcgcc gccccataaa aatccttctg gaaatcgttt ttcatttgaa ctcatattga 3395401 tcaccccatt agttttttca agataaagca agcagcgctt cttttggctg cactttaccg 3395461 atctctttca ccggcgaaaa cgaatattgg tctgtgttgg tcacaatcac cggggtaatg 3395521 acgtcatatc ccgcggcttt gatttgctcc agatcaaagg acacgagcgg atctcccggt 3395581 gcgaccttgt cgccttcttt gatgtgagcc gtgaaccatt gtccctccag ctttaccgtg 3395641 tccaatccaa tgtgtatgag tatttcagct ccctgatcac tcgtaatgcc aattgcgtgt 3395701 tttgttttaa aaatggtggt aacgcttcca cgaacaggcg aaacaacttc tccttcttca 3395761 ggctcaatgg caaatccttt tcccatgacc ccagcagaaa acactccgtc tttgacttca 3395821 cttaaggctt tcacttctcc cttaatcggg ctgtgaatga tctctctgct gccttcatgc 3395881 actgccggct gctggctgcc gtcagaaggc acatcctcga atccaagcaa atacgcagct 3395941 gctgttcccg ccgcaaacgc aatcacaagg ccgatcatcg cgtaaataaa cgttgggccg 3396001 ataaagacag ggatgctcgg cagacctgca ttccccccga cgatatagga agcaacaccc 3396061 gtcatgccgt aaaacgcgcc accggctgca ccgccaatca aagcggccgc aaacggcttt 3396121 ttcaatcgca tattcacgcc gtacatcgca ggttctgtga tccccatcag cgccgtgatg 3396181 cttgtggtaa gcgcgagtga tttaaatttt ttgtttctag agcgaaggaa gacggcaaat 3396241 gatgctcccg cctgccccat attcgccaaa aacatagccg gcagtaaata atcgtggccg 3396301 ttttgagcga tgttgttgat catgatcggc acaaaggcat agtgcatgcc cgtcataatg 3396361 attaaagaga atgtacccgc cagcaaaatc attgccacaa gccctgcatg atcaaacaaa 3396421 taattgaccc cagaagacaa gtattctcct aaaatagcgc caagcggacc gactgtaatc 3396481 aatgtcagcg gcacgacaat caatagcgtg aatgtcggaa ccacaatcaa tttgagagat 3396541 gcgtgtgtaa aacggtcaat ccatttttcc acgtatgaag caatccaaat cgacagcaaa 3396601 atcgggatga ccgttgacga ataagtggca gcggttacag gaagcccgat aaaggaaatc 3396661 ggtttccccg caccgagcag ggctgtcaaa tccggatgca ggatcgccgc cgcaatggca 3396721 gccgctacgt acggattgct tccgaatttt ctcgccgcac tcatcgctag caggagcggc 3396781 aggaagtaga acgcaccgtc accgacagcc gtcaaaatga catgaacctg gctcttctcc 3396841 gccatccagc caaacgtgac tgccagcgcc acaagtcctt tgatcatccc cgctcccgca 3396901 atcgcaggca gaataggggt aaacacccca gaaatcacat caaagaccgc actcagcaca 3396961 ttctttttct gagaggatga accagcgctc ttttcatcac tgagattgct gtgccgcaca 3397021 atcgcctgat acaccttcgg cacatcgttt ccgataatga tttgaaactg ctcgccgctg 3397081 atattggtgc ccatcactcc aggcagctgc tccagctgac tgcgatccgc cttcgcgttg 3397141 tcatgaagat taaaacgcag cctcgtcatg cagtggatca cgcgctgaac gttttcttca 3397201 ccgcctacga gttgtaatat gtccttcgat aatttatcat aatccatgtg tatacctcct 3397261 ttttatgggg ggactgctgg atgaaaggtg gccgcctttc accagctttt tttgtatcaa 3397321 atgctgcatc acctcctaaa agagaataaa aaaacctaaa tgacacagat tgcgagagtc 3397381 tcctcctgca cctgcaccat ttaggttttg cctgctttcg cagtaacaat cctgacgggt 3397441 cgttttattt gtttgtaggt atactttagc actagattcg tgagatgtca acgctttcat 3397501 ttttggtgtt gactatcgtt tctagaacaa aagtaatcat aaagatttga acttagtatt 3397561 aacttcaata aaaaattatt gtaattaaaa accttgaaag gcattttttc caatcaaggt 3397621 tatgaatcgt taccgtttaa atttttttaa agacttcttt atctgtacta ttacattctt 3397681 tagccaatct attggttcta aattaaacgc aggaagatac acgccatctg cgcaagattg 3397741 aatgtaatcg tttttcttat tgtctgaatg ctcactttca ataaaatccg ttaaaaagac 3397801 aatagcatcc tccaaatatt ccttactttc ctctattaat aactcttgta tagcgtcatc 3397861 aggagtttca atatcttgat ggaatgttcc agctaaaaac tgaaaaacag ggtccttctg 3397921 tttattgatc aataacatgt catcttgctc ctttaaggga gaggtaacgg gataatgtta 3397981 aaatcattca tcatctaata aatcaagata atactgatca ttctcttcta tttttcttaa 3398041 gaactcggta agagaagttg caatttgaat atcataatag taaatcggat ttttattatt 3398101 atcatttaat tcaattgaca ttaatgccga ttcactacct tcaaaaaata ttaatttatc 3398161 attctcaaac tcatcatata tttctatgtc aggataaaat tcaaagtcat ttatcctcaa 3398221 tcgaaagtct cttacagaat atggatccaa aatgcgatta gtattaaact ctgatccttt 3398281 aataaaccca tagccaactt ctaaataaaa attcactaat tcactaggta attttaagtt 3398341 taaatttttt tcaacctctt caatctcact ttgattcact ggataaaaat cattttcttt 3398401 gtttgatttt ataaaattat aactcatttt tttttgcctc ctttaaataa ttcatttgct 3398461 ggtgagcctg taccatgaat cccagcttga tgctcgttag gaaattttgc tggatgcata 3398521 ttccaccatt catgttctcc gccaaaagta ttttcaatta tatggtgagc atcatactta 3398581 tccccttttt ttctaataat tttacctgtt ttttcagata caacattttc cttataaaca 3398641 ggccattttt gtccagtgtt ttcttcccat tcttttataa ctttattttt tactttatca 3398701 aatttagtcc tgtgttttgc agtctctatt ggtgacattt ttttatattc tttatttctt 3398761 aatgcttcct ttaatttatc tatttgattt ttaggtaatt ctctacctgt gcgttgttct 3398821 atatctctag catacttttt tattaaatca gaattaattt tattagcaga tccacttaca 3398881 tcattcgcaa ttttcccttt atccttagca acgtttttaa cttccgaagc cttcttagcc 3398941 tttttcccat tattaataag tttattaata tctattaact tttctaactt agctattttg 3399001 gcaaatggta ctgagtttat ggaggcaaca acacggtctt tccctgtgac tttttcgcct 3399061 gataccggat ctctgcccgt ggctgcttta aatagatcat acacgccggt aagttctaca 3399121 gccgtctcta aaattttcac atatccattc tcatccactt taatgtccga aagcgagacg 3399181 acaggttcaa gcttcatgtc attaccagat atgtatacat tgtaaagtgt atcattataa 3399241 acgacttgct taacctctgc atttgagaaa tcagttttta tatgttctct atgttcactc 3399301 gtattataca ctttaccatt gataacgatg atatttttac ttaccttttt agaatcaccc 3399361 gttttgacaa ctgaatccac tttagacttt tcattctcgg ctaatttctt cagcatcatc 3399421 tccatcggtg aatcatccgc ctgcttcatt tgcgggttaa tcgcgccgaa gatttggttg 3399481 atgttttctt cttcctgtga tttcaggatg gagccgcttt tgtagcctgt gatttcaatt 3399541 ttcgggccgg tgtacatggt ttcgagctga tcaatgtatt ttttcatcgt ttgaaaatct 3399601 gattttgcgg cttctagtgc ttgggtttgc tggccgtcaa attgaaagag cttattcagg 3399661 gtgtctgaaa tcagccgctc agcctgttct gtttccatcc gaaaaaagga atcattgact 3399721 gtcggcaggc tgacgatgtg atctatggct gatgtctggc gattgactgc gtcagtgagc 3399781 tgctctgtca cttctcgtgc atgcttgacc ccatgtctcg catcgtgtga gagaaaagcc 3399841 tctgcgatca tgccgtggga gttagattct acagaggaaa tcgcatgctg tgtttgtttc 3399901 agcacttttt tgtattcgtc gataaatatg ccaaagaaaa ggagaaaagg cttgtggcac 3399961 tcctcgtaaa aggtccggat ggcatctccg ccttttcctt tcagcgcatc cttcatgcct 3400021 gccagatgct caacgctttt ttccagcttc tccagctgtt gtttttgctt gtccagtttc 3400081 tcaatcgtat gctgaatgcc ctcgtgaaga gcgtggacat ctaatgtttt caatcccttg 3400141 tcctcccgcg ctttatttca tggaagatga tatgttttcg tccgtttcct tcatggcgtt 3400201 taccgcgctt tccgtttgtg cgatatgctt ggccagaaca gacgcatatg cttcagtgag 3400261 ctctttgatg tccttattta attgctcgat ggacttcaca acattcaaat ggtttctgcc 3400321 tgagagatga ccgggcaatg aggacttgag ttcagctgaa ttcttgagct gagaaagccc 3400381 ttgcttcact gtgtcataca ccattttaat ttcctgtgcc atttgtgctc acctcacttt 3400441 ttatgttttt ccttctctat ttcatgctct atcctcgtga tttggcgtct tatagaatac 3400501 acatcgccct ctaatgagtg gatttttcct tctatgcttt cgatgattcc gctgacttga 3400561 tcgcttttga tttgctgata tgctttgttc attccttcac gaatatcttc aaaccgctca 3400621 gcatgtgttc ctctccatgc ctcccggtta agatgaggcc ggtgaatgag atgctgggcc 3400681 tcagagaaat cgtgtttgat ttgcctaatt tcgtgcagca ctcgttttaa ttgatggatc 3400741 tgttcctgct tttcatgtaa gtcggctttt accgaatgta acaacatttc actatgcatg 3400801 ccgcaacacc tcgtgtttct atcaaactgt gtaaattctt tacaatacag actattttca 3400861 tattacatga tgggtcatat tggataaata ggtaaaaagg attgtcttga gaggtataga 3400921 actggttcta aattgctaaa aatacgatct catcacccta tgaaaggaga aaacaatcat 3400981 agtagggact ttttatttaa gcctttaatc tctcctccag ttctaatttt tcctcccact 3401041 taactgtttc ttatagtcaa taaagctcat aaaaaaacac cttccctcga aggcgcttct 3401101 ccatcttatt tagatcccca tacagcctca ccgctggtat tcagcacact aaacgtcatg 3401161 acgttcttct ctctcaccga atcccactgg cgtaaaaata ccccgttata cttcttgcct 3401221 gctaacgtga tgtcggcggt gttttttccg gttttcctcc atgttccggt catttccccg 3401281 gaaatggtgt ggtttttgtt gagctggatg ttgatggttt gtttgatgtc ggctgagatg 3401341 tcttttccgt gctggataag tttgtatgtt cctgtgatgt ctttttgttt tacttctttc 3401401 aatgtttcgc ccgcataacg atatggtgct gctaccggcc agccgtcttt gttcatgaac 3401461 aattggtgga ctctgacttc gtgttcttca cccctgcccg ggaagcgggt gtggaagatt 3401521 aaataggaac gcccggtttt ttcatcatag tatgcggagt tgtggcctgg tgagacgtac 3401581 ccggtgcctt tttcattttc tgtttcaaaa gtgtagctgc ccatgagttt gacgccgtat 3401641 ggttcgatgg aacggtcgtc gaagaatgtg cctcccttgc cgcggacgtc gagcattgga 3401701 ttgccttctg catcatagta agggccgtcc ggtttcttgg agcgggccac acggatgttg 3401761 tagccgcctg ttgcatcgag accgccatat gataggtata agtagtagta ttgggtgtct 3401821 ggattgtaga gaacatacgg gccttcgatt ctgctgtggt tgccgccgag cagttttttc 3401881 ccatatccct gtccaggaag cgggaagccc gttttcggat tcatttcaag tatgaaaatg 3401941 ccgcctgagt atgatccgta caccatccac agcttgccgt ctttatcaaa gaaggtatgc 3402001 gggtcgacga cattcggatg tttggttgca tcatacggtg ttccatcgct gcttgtgcct 3402061 tccattcctg atttcaaaaa gatgcctttg tttttgtatg ggccttcgat gttgtcagca 3402121 acggcaacac ccatggcgga tcttggcgaa tcgccgcggc aggcgttgta gtacatgtag 3402181 tatttgccgt ccgccagctg cgtgacgtca gccgcccaaa gagtatcgga ttgcgcccat 3402241 tcgaaggttt cttttaattc ttcatagaca ttcgggataa gtgggttgtc attgcttacg 3402301 ctggtggtca gctgctgcca ttgcatgagg tcattcgatt tagctgaagc gagatgagat 3402361 ccaaaaacat aaaaagtgcc gtttgtttca atgatggaag ggtcatggac gctgacttct 3402421 ttaaatatag gtttttgtgc atagacggag tttgggaggg tgaaggccat gataagagct 3402481 gcaagaaaac atacacggaa caatcggttg aacatctaaa caattcgcct ctctttttta 3402541 ttaaatttta aacgcttaca tttctctatg aagatacccc ggcctattaa aacagccgaa 3402601 tgttttcata ttcatccaga taggtgattt ctcacttcac ttacatagtc agactgatgt 3402661 ctgtctgttt tgcgcagaac ttgttgcttg catatcctct ccttcatagt tcaactcttt 3402721 tgctgtttct ccttcttgca tcacgtctgt ttttctttcg cgtacatgta ataactgctt 3402781 tgtcaggttt tgcatcaact gtgatacagc catttcgttg tcggcgtttt ttaagatgat 3402841 gcctgattgc ccgtcaacac cagagtcatt cggctggctc tttataaaac gccttgcgaa 3402901 aaatacgact tagtaaacgc atattgagag ttagacagcg gcgcttgcct ccttgtctgg 3402961 atatcgtgtg caatcgctga aaaaacctgt tctgctttct gcgtcacgct attacaatag 3403021 caatctaact tgttaaagac tataaaaaaa ccttttgact tctgctgctg aaccaattaa 3403081 tataatactc agttaatagt tatcagaatt tttaggaatt gagtgattca tatgacactg 3403141 cataaagagc gtcggatcgg ccggctgtct gttctcctgc tgctgaatga ggcggaagaa 3403201 agtacgcagg ttgaggagct ggagcgagac ggatggaagg tctgtcttgg caaggtagga 3403261 tcaatggacg cacataaagt agtagccgca attgaaaccg cttccaaaaa gagcggtgtc 3403321 attcaatctg agggttatcg ggagtcacat gcgctttatc atgcgacgat ggaggctttg 3403381 catggcgtga ccagaggtga aatgctgctg ggatcgctgc ttcggacggt gggattgagg 3403441 tttgccgttt tgaggggaaa tccttatgaa agtgaagcgg aaggcgattg gatcgctgtc 3403501 tcgctttacg gaacaatcgg ggcgccgatt aaaggtcttg agcatgaaac attcggcgtt 3403561 ggaattaatc acatatgaaa cagcccatag atcttagacg atagggggct atgcgtgaaa 3403621 acagaagttc acagcatagc tcctttttgt atgggcgctt taccaaagta aagaaaaagg 3403681 agttgggctt atggtgactt tagacggttc ttcattgaca acagccgacg tcgctcgtgt 3403741 gctgtttgat tttgaggagg cagcggcttc tgaggaaagt atggagcgcg tgaaaaaaag 3403801 cagagcagca gtggaacgga ttgtacgcga cgaaaagaca atctacggca tcaacaccgg 3403861 atttggcaaa ttcagcgatg tcctgattca gaaagaagac tcggcggcgc tgcagctgaa 3403921 tttaatcctt tctcatgcct gcggagtcgg cgaccctttt cctgagtgtg tttccagggc 3403981 aatgctgctt ttgcgcgcca atgcgctgtt aaaaggcttt tccggtgtac gcgctgagct 3404041 gatcgagcag ttgcttgctt ttttaaataa acgcgtccat cctgtcatcc ctcagcaagg 3404101 atcacttggc gcaagcggag atctggcgcc gctttcccac ttggcgcttg cgctgatcgg 3404161 acaaggagaa gtcttttttg agggggaaag aatgccggca atgacaggct tgaaaaaagc 3404221 aggtattcaa ccggtaacgc tgacatccaa ggaagggctt gccttgatta acgggactca 3404281 ggccatgact gcaatggggg tggtcgccta catcgaagct gagaaactag cctatcaaac 3404341 agaacgaatt gccagcttaa cgattgaggg gttgcaggga attatcgatg catttgacga 3404401 ggatattcac ttagcccgcg gctatcagga gcagatcgat gtcgcagaac gaattcgctt 3404461 ttatctatct gacagcggcc tgacaacctc ccagggagaa ctgcgggtac aggatgccta 3404521 ttcattgcgc tgtattccgc aagtacacgg tgcgacttgg cagacactag gatatgtcaa 3404581 agaaaaatta gagattgaaa tgaacgcagc tacagacaat ccactcattt tcaatgacgg 3404641 tgacaaagtg atttccggcg gaaactttca cggacagcca atcgcctttg ccatggattt 3404701 tctgaaaatc gcaatatcag agcttgcgaa tatcgcagag cgtaggatcg aacgacttgt 3404761 gaatccgcag ctgaatgacc tgccgccgtt cctgagccct catcccggtc tgcaatccgg 3404821 tgcaatgatc atgcagtacg ccgcggcctc actcgtttct gaaaataaaa cactggccca 3404881 tcctgcaagt gtggattcca ttccgtcatc cgccaaccaa gaggaccatg tcagcatggg 3404941 aaccatcgcc gctcggcatg cttatcaggt gatcgcaaat acaaggagag tcattgcgat 3405001 cgaagccatt tgcgcattgc aggctgttga atacagaggc atagaacatg cagcgtccta 3405061 tacgaaacag ctttttcaag aaatgagaaa agtcgtgccg tccattcagc aggaccgtgt 3405121 tttttcctat gacattgaac gcttgactga ctggctgaag aaagaatctt taatacctga 3405181 tcatcagaat aaagaactaa gggggatgaa catatgactg atgtaaaaaa atcaatccgt 3405241 gccaacagag gaacagagct tgaatgctta ggatgggagc aagaggcagt gcttcggatg 3405301 cttcgaaaca accttgatcc agaagtcgcc gagaagccgg aggacctcat cgtatatggc 3405361 gggattggca aagccgcacg ggattgggac gcttttcacg ccattgagca ttccttgaaa 3405421 acattaaaaa atgatgaaac attgctcgtg caatccggaa agcccgttgg catgttccgt 3405481 acacacccgc aggcccctcg cgtgctccta gcaaattctg ttcttgttcc gaagtgggca 3405541 gactgggagc atttccacga acttgagaaa aaagggttaa tgatgtacgg acagatgacg 3405601 gctggcagct ggatttacat tggctcacaa ggcatattgc aaggaaccta tgaaaccttc 3405661 gctgagctgg cgcgacagca cttcgggggc agcttaaaag gaacgttgac gctgacagcg 3405721 ggtctcggcg gaatgggagg cgcccagccg ctgtcagtca cgatgaatga aggcgtcgtg 3405781 attgccgtcg aggttgacga gaaacgcatc gacaagcgga tcgaaacaaa atactgcgat 3405841 cgaaaaacag catcgattga ggaagcctta gcttgggctg aagaggcaaa gctggcagga 3405901 aaacctttgt ccattgcact tctcggaaac gcagctgagg tgcatcacac acttttgaac 3405961 cgaggcgtca aaattgatat tgtgacagat cagacatctg cccatgaccc tttaatcggt 3406021 tatgttcccg agggctattc ccttgatgaa gctgaccgtt tgcgtcaaga cactccagag 3406081 ctttacgtgc gccttgcgaa gcaaagcatg aaaaaacatg tcgaagccat gctggccttt 3406141 cagcaaaagg gctctattgt atttgactac ggcaacaata tccggcaagt cgcaaaggat 3406201 gaagggctgg agaatgcctt cgattttccg gggtttgtcc ctgcctacat ccgcccctta 3406261 ttctgtgaag gaaaagggcc gttccgctgg gcggcgcttt ccggagatcc ggcagatatt 3406321 taccgtacgg atgcgttatt aaaagagctg ttcccgacaa ataaagccct tcaccgctgg 3406381 attgatatgg cacaggaaaa agtcaccttc caaggcttgc cgtcccgtat ctgctggctt 3406441 ggatatggag aacgaaaaaa gatgggcctc gccattaacg agctggttag aaccggggag 3406501 ctaaaagcgc ctgtcgttat tgggagagat catttggact gcgggtctgt cgcctctcca 3406561 aaccgggaaa cagaagcgat gaaggatgga agtgacgctg tcggtgattg ggctgtgcta 3406621 aatgcgcttg tcaacacggc ggcgggtgca agctgggttt ccttccacca tggcggcggc 3406681 gtcggaatgg gctattccct tcatgccggc atggttgcag tggccgatgg aagtgagctg 3406741 gctgacgagc ggctcgcgcg ggtcttaacg agcgacccag gaatgggcat tatccgtcat 3406801 gcggatgcgg gttatgaacg tgccgttgaa gtagcgaagg aacaggacat tatcgtgccg 3406861 atgcaaaaat aaaggagtga tgacatgcca aagcaaattg atacgattct catcaacatc 3406921 ggtcagcttt tgacgatgga aagcagcggt ccgcgggcag gcaaaagcat gcaggatctt 3406981 catgtgatcg aagacgctgt tgtcggcatc catgaacaga aaattgtgtt cgccggacaa 3407041 aaaggggctg aagccggtta cgaggcagac gaaatcattg actgttcggg acgccttgta 3407101 acgcctggcc tcgttgatcc gcacacccat cttgtatttg gcggatctcg tgaaaaggag 3407161 atgaacctta agcttcaggg catttcatat ttggatattc tggcgcaggg cggcgggatt 3407221 ctgtctacag tcaaggatac cagggcggct tcagaagaag agctgctgca aaaagcccat 3407281 tttcatctgc aaagaatgct gtcctacggc acaaccacag cagaagtgaa aagcggctac 3407341 ggcttggaaa aagagacaga gctcaaacag ttgcgtgtcg caaagaaact gcatgaaagc 3407401 cagcctgttg accttgtttc cacatttatg ggagcccatg cgattcctcc cgaatatcaa 3407461 aacgatccag atgattttct ggatcaaatg ctttcccttt tgccggaaat caaagagcag 3407521 gagctcgcca gctttgctga tatttttaca gaaacaggcg tttttacagt cagccaatcc 3407581 cgccgttatt tacaaaaagc agctgaggca ggcttcggat taaaaataca cgcagatgaa 3407641 atcgatccgc ttggaggtgc tgaattagca ggtaagctaa aggccgtctc agccgaccat 3407701 ttggtaggta catcggacga aggcataaag aaattggctg aggcaggaac gatcgccgtc 3407761 ctcttgccgg gcacgacatt ttatcttggc aaaagcacat acgccagggc aagagctatg 3407821 attgatgaag gtgtatgtgt cagcttggca acggatttta atcctggcag ctcgccgact 3407881 gaaaatatcc agctgattat gtccattgcc gcgcttcatc tgaaaatgac tgcagaagaa 3407941 atatggcacg cggtcacagt caatgccgca tatgccatag gaaaaggaga agaagccggt 3408001 cagctcaaag ctggccgctc agctgatctt gtcatttggc aagccccgaa ctatatgtat 3408061 attccgtatc actacggggt caatcatgta catcaagtca tgaaaaatgg aacaattgtt 3408121 gtcaacaggg agggagccat tcttggataa gtaccctttt ctcagagagg ccggatcttc 3408181 gtttaaagac cgggatgtca caaaaatgag cgacctgatc gcaacatggg acggccagga 3408241 cattaaggga ccggcgttga taggtgtccc cctatcaaaa tcctccatca gtcattcagg 3408301 cgcttccttt gcacccggaa caatacgcca ggctctgaaa cattcatcag cctattctgc 3408361 tgagcttgga gagcacgtcg tatcagagct tctatatgac ctgggggata tcgatattca 3408421 tgtcactgat atcgtaaagt cacatcatca cattttccaa accatgcacg ctctgctttc 3408481 ggatcatccg gattgggtgc cgctcatact tgggggagat aactctatca gctactccac 3408541 aataaaagcg atagcacaaa caaaaggaac gacagcggtg attcaatttg atgcccatca 3408601 cgatgttcgc aatacggagg acggggggcc gacaaacggc acccccttcc gccgcctttt 3408661 ggatgaagag atcattgaag gtcaacattt gatccagctg ggtatcagag aattcagcaa 3408721 cagccaggcc tatgaagcat atgcaaaaaa acataacgtg aacattcaca cgatggacat 3408781 gatccgggaa aaaggactaa tcccaacgat aaaagagatt ttgcctgttg ttcaagataa 3408841 aacagatttc atttttatat ctgttgacat ggatgtctta gaccagtccc atgcacccgg 3408901 ctgtccagcg attggcccgg gcggcctcta tacagacgaa ttgcttgaag cagtcaagta 3408961 catcgcacaa cagcccaatg ttgccgggat tgaaattgtt gaagtcgacc ctaccctcga 3409021 ttttcgagat atgacaagca gagctgcagc tcatgttctg ttacacgcat taaaaggaat 3409081 gaaactctcc ccattcaagt gatcttctgg caggttgtat tttgggtata agaaactcat 3409141 ctgcctaagg aatggcagct aaaaggaggg cgagacagtg aatcttcagg agaacagcag 3409201 ccaacagcta aaacgcacaa tgaaaagcag gcacctattt atgatctcat tgggaggcgt 3409261 cataggcaca ggacttttcc tcagtacggg ctatacgcta catcaagccg gacccggcgg 3409321 tacgatactc gcttatgtaa tcggcgggtt gatgatgtac ctcgtcatgc aatgtctcgg 3409381 cgaattgtcg gttgccatgc cggtgaccgg ctcttttcaa aaatatgcta caacatttat 3409441 cggtccatct accggtttta tggtcggcat catgtactgg atcaattggg tggtgacggt 3409501 aggctctgag tttaccgcat ccggtattct catgcagcgc tggttccctg acagcagtgt 3409561 atggatgtgg agtgcgattt ttgcagccct tctttttata tgcaacgcat tttcagttaa 3409621 gttatttgcg gaaactgaat tttggttttc cagcgtaaag attgtcacca ttattttatt 3409681 tatcatttta ggaggagccg ccatgtttgg cctgatctct ttaaacggaa cggcggatgc 3409741 tcctatgttg tcaaacttca cagatcatgg cgggttgttt ccaaatggct ttctcgccgt 3409801 ttttatcgcg atgatatctg tgagcttcgc cttttccggt acagagttaa tcggcgttac 3409861 agcaggagaa tcagcaaatc ctcaaaagga tataccgcga tccatccgta atgtcgcatg 3409921 gagaaccgtg atttttttca ttggcgctgt cttcatatta tccgggttga tttcatggaa 3409981 ggacgcaggc gtgattgaaa gcccgtttgt cgccgtattt gcggagatcg gaattcctta 3410041 cgctgctgat attatgaatt tcgtaatatt aacagccttg ctgtctgtcg ccaactcagg 3410101 cttatatgct tcgacccgta tgatgtggtc tttagcaaat gaaaacatga tcagctcccg 3410161 ttttaagaaa gtgacatcta aaggcattcc tttaaatgcc ttaatgatca gtatggctgt 3410221 atcttgttta tctctcgttt ccagtatcgt ggcccctgga actgtctatg tggtgatggt 3410281 cgcaattgct ggatttgcag gagtcgtggt ctggatgagc attgccttgt cccaactctt 3410341 gtttcgaaag agatttttga aaaaaggggg ggatgtaaaa gatctgacat ttcgcacgcc 3410401 gctttatcct cttatgccta tagccgctct cttattatgt tctgcttctt gtatcggtct 3410461 tgcttttgat cccaatcaaa gaatcgcact tttctgcgga gttccttgta tcatcctttg 3410521 ctatctcatc taccatttca aaagaaatgt tacaaaagcg aaaaaaatca gccaagagga 3410581 atatccagcc gatcacatcc tataattaaa aaagcacacc ccgctcagca tgggatgtgc 3410641 tttatttttt attctgtaat taacgtatga atcagcttcg gcgccttcgc ttccgcggcg 3410701 atgcggatgt tgtcatagac ttttgcgatg acttcatcga cgttttctcg gttagcgtaa 3410761 agcgttacga gcggttcccc tttttctact ttgtcgccga cctttttgcg gagcatgatg 3410821 ccgacggcta aatcgatttc gtcttctttt gtggcgcggc cggcacctaa cagcatcgcc 3410881 gcgacgccga tttcgtccgc gacgatttca gagacgacac ccgcttcttt ggcaggcaca 3410941 tcaatttgat atgcggcttg cggaagctta gacggatcgt caacaattga gctgtcgccg 3411001 ccttggtttt tcaggaaatc cttgaatttc tcaagtgctt tgccgttttt catgacttct 3411061 tccagcttcg ctctcgcttc gtccaatgta tcggcttttt tcgcaagcac aaccatctgg 3411121 ctgccgagcg ttaagacaag ctcatgaaga tcctcaggcc cctcgccttt gagcgtgtcg 3411181 atcgcttctt tgacttcaag cgcatttccg atcgcaaagc cgagtggctg ggacatgtct 3411241 gaaatgacag ccattgtttg acggccgacg ttatttccga tgcgtaccat cgctttggca 3411301 agttcagctg cgtcttcttc tgttttcatg aaggcgcccg ctcccgtttt tacgtcaagc 3411361 acgatggcgt ccgccccggc agcgattttt ttgctcataa tcgagcttgc aatgagcgga 3411421 atggaattga ccgttcccgt tacatcacga agcgcgtaca gttttttatc agccggcgtt 3411481 aaattgccgc tttggccgat gaccgcaacc ttgtcgcggt tcacaagttt aataaattca 3411541 tccttcgtca gttccacgtg gaagcccatg attgcctcta acttatcaat cgtgccgccc 3411601 gtatggccga ggccgcggcc ggacatctta gcaaccggca catcaagagc cgcaacaagc 3411661 ggagcgagaa cgagcgttgt cgtgtcgccg acgccgccgg tagagtgttt atccacttta 3411721 attccttcaa tggcagaaag atcaatcgtt tcaccggagt tcaccatagc catcgtcaag 3411781 tccgcgcgtt cacggtcact catatcctgg aagaaaatcg ccatagcaag cgcgcttgcc 3411841 tgataatcag gaatgcttcc atctgtatag ccgttcacaa aaaattgaat ttcttcagtg 3411901 gtgagttctt ttccgttttg ttttttgatg atgatatcta ccattctcat gtttggtcac 3411961 cgatcctttt cgattaagtt cagtaaatca agcccacaat tgctgctgat aaaaagctga 3412021 caagcgtagc accgtataat aatttcaagc cgaaacgagc gacgacattt ccttgctttt 3412081 cattcagtcc ttttacggca ccggcaatga ttccgattga ggagaagttc gcaaatgaca 3412141 caaggaatac cgatacgatc gctgttgtac ggccgctgaa atggaaaccg ttttgcgtaa 3412201 gcgacgtcat ggcgacaaat tcattcgata ccatttttgt tgccataatg cttcccgcat 3412261 taacagcttc attccatggg ataccgacaa gaaaagcgaa tggagcaaac acatatccaa 3412321 gaatgccttg gaacgaaata ccgaatactg cattaaaaat gccattgatc aatgcaataa 3412381 tcgcgacaaa tccaatcagc atcgcagcga cgacaaccgc tactttgaaa ccgtcaagaa 3412441 tgtattctcc gagcacttcg aagaaggatt gtttttcttc ttcctcaaca cgaagcatat 3412501 cctcttcttt tgcaacctcg tacggattga taatagaagc gataatgaaa ccgccaaata 3412561 agttcaaaac aagcgctgtt acaacatatt ccggtttcag cattgtcata tacgcaccga 3412621 caatcgacat tgatacagtt gacatcgcag atgcgcaaag cgtgtacaag cgctgctgat 3412681 ttaaaagacc gagttctttc ttcaaggaga taaatacttc tgactgccct aaaatcgcag 3412741 aagccactgc gttatacgat tccaatcttc ccataccgtt taccttgctg agggcaaggc 3412801 cgatatatct aatgataaac gggaggactt tccacttttg cagaatcccg atcagagcgg 3412861 aaataaacac gattggcaag agaacattca taaagaatgt cgtttggtcc gcattcacca 3412921 agccgccaaa cacaaagtta attccctctg ccgcgtattc aagcaggtaa ccgaatcctt 3412981 ttgcaaatcc tcccacgagg aaattcccta ttccggtatt gaggagaatg tagccaagaa 3413041 taaattgcaa aatgagcata acaacaattg ggcggatctt aattcttttt ttgccgctgc 3413101 tcgcgatcca cgcgaggcct aaaaacacga ttaaaccgat aatcccaatc aaatacttca 3413161 tatgtgtttc tcctttattt gtattcgctt acaattactg tttcctcaga aaacggaaag 3413221 cagtctgcct tccgtcagct cttaatagtt gtctccgcct gatgcatttt ctccttttac 3413281 gatagaaacg cctgcgctgg cgccaattcg gcttgctccg gcctctacca ttgtgtctac 3413341 atcttctttc gttctgacgc cgccagatgc tttcacgccg atatcaggcc ctactgtttt 3413401 gcgcattaag gcgatatctt ccttcgttgc gccgcctgta gaaaagcctg ttgatgtttt 3413461 tacgaaatcc gctcccgcag acaccgctaa acggcatgca cgttcttttt cttcatcagt 3413521 cagaaggcac gtttcgataa tgactttgac aagcgctttt ccggctacag cttccactac 3413581 accgcggata tcagcttcca ccacatcgtc ttccttgtct tttaaagcgg caatattaat 3413641 gaccatatcc acttcagtgg cgccttttga aatggcgtct tttgtttcga acgcttttgt 3413701 ttcagttgta ttggcaccga gcgggaagcc gatgaccgta caaacgtcga ctccagttcc 3413761 cttaagctct tttgcagcaa gctccaccca tgtcggattg acacatactg aagcaaattt 3413821 gtatgttttc gcttcttcaa ttagttttag aatgtccgct ttttgtgtat gcggtttcaa 3413881 agctgtatga tcaattatgt tggctaatga catccttcgc acacttcctt ttttgttaag 3413941 atatttttta gcataaccga cttttgaaca tatgtaaatt ggtaattgaa attttgttca 3414001 atgaaaggtt tgaacgtgtc acaaatcatt aacaagcgcc ctcgcggtat gctggtcaat 3414061 gattaaaacg ttggcatatt ttccggttaa tgctccgtga atggaagata cttttctgct 3414121 tccgccggca actaaaatgg agcgttcctt cagtctaagg tcttgaagct caacaccgat 3414181 ggtccggtca ttgatggcgc tgctgcaaat attccctttc gcatcaaaaa agcgtgaaca 3414241 aatatccccg acggcctgtt ttttcagcag ggctttctct tcttcgttaa aatatccgag 3414301 ccgaaacaac agcgcttcat cacggacagt cccgaccgta aagagagcga tattcgcctg 3414361 cttgcccatc tcaatgatcc gttcaatatg acggtctttc tccaccattc gcttcacatc 3414421 cgcattatca aacacgacgg gaagcgggag atagcgcggc atcgtttgaa aagcctctgc 3414481 aaacagctga atcgtttcag ccgaatacgt gtttacccgg gaatggctga tgccgccttt 3414541 cagctggacg acctcgacgc cttttacctg cttcggctgc atgttttgcg cgatttgata 3414601 catggtggtt ccccagctga cgccgacaat gtcgccgtct tttaccgttt catgcatata 3414661 ttctgcacca tagcggctta ggtcatgtgt aattcctgca taatcgggtg tcggggaaaa 3414721 cacaacatgc gcctcaagga gcccgtattt ctcttcaagt atggaaccga gcgcatccaa 3414781 atcctcaaaa gggtccatga cgcgaatctg gacataccct ttttcctttg catattgcag 3414841 cagccgggaa acggttggcc ttgaaatgtt gagctgctca gcaatttgct gctgactgta 3414901 gtcagactga tagtaaagcc ttgccgcttc tatgcttaat tgctgttttt cccgatccat 3414961 tctgcacctc cctgtggatc agtcctgata aaactgcttt tgatttgctt ttattataca 3415021 ggctggcgcc ggctttcatc cacctgattt ctaagaaact gaaaaacgct ctgggcgcgg 3415081 acctgcccag agcttacttc tcccaagtcg gtttctctga gcataaagtt atttcgtttt 3415141 tcctaaactc agcggatctg tgatcatctc ttttggctat aaagtttccg ttttttcaaa 3415201 acaaatgttt caaatgagat aggaaatggg tactaatcta ttaactttgt tacatatttt 3415261 tagatactca ttggctcaac aactgaggag gagacatttg tgaagaaaga cacaaggaaa 3415321 tatatgatct actttttcgg cgctttaggg ggactgctat atggttacga tacaggtgtt 3415381 atctccggag cactcctgtt tatcaataac gatattcctt taacgacatt gacagaagga 3415441 ttggttgtca gcatgctgct ccttggcgcg attttcggtt ctgccttgag cggcacatgc 3415501 tcagaccgct ggggcaggag aaaggttgta tttgtccttt ccatcatttt tattatcggt 3415561 gcgctcgctt gcgcattttc tcaaacaatc ggcatgctga ttgcatctag ggtgatactc 3415621 gggttggccg tcggcggttc aacggcactt gtgcccgtgt atctttccga aatggcaccg 3415681 acgaaaattc gcgggacact cggcacaatg aacaacttaa tgattgtcac cgggattttg 3415741 ctcgcctata tcgttaacta cctgttcaca ccgtttgaag cgtggcgctg gatggtcggt 3415801 ctggctgcag tgcctgccgt gcttctatta atcggcatcg ccttcatgcc ggaatcgcca 3415861 agatggctcg tgaagcgcgg cagcgaagaa gaagcgagac gcatcatgaa catcactcat 3415921 gaccccaaag acatcgaaat ggaattggca gagatgaagc aaggggaagc ggagaaaaaa 3415981 gaaacgacac ttggcgtgct gaaagccaag tggattcgcc ctatgcttct gattggcgtc 3416041 ggccttgcca ttttccagca ggcagtcggc attaacacgg tcatctacta cgcgccaacc 3416101 atttttacga aggccggtct tggcacatca gcttcggcgc tcggcacaat gggaatcggc 3416161 atcctcaacg tcatcatgtg tatcactgcc atgatcttaa ttgaccgtgt cggccgcaaa 3416221 aaacttctga tctggggaag tgtcggcatc acactgagcc ttgctgcttt atcaggcgtg 3416281 ctcctgacac tggggctttc cgcatcaaca gcgtggatga cagtagtctt tctcggtgtc 3416341 tatatcgtct tttaccaggc gacatggggt ccggtagtgt gggtgctcat gcctgagctc 3416401 ttcccgtcca aagcacgcgg agccgcgaca gggttcacga ctttggtgtt atcggcggct 3416461 aacctgatcg tgtcgcttgt cttcccgctg atgctaagcg cgatgggcat cgcatgggtc 3416521 tttatggttt tctcagtcat ttgtcttctc tcatttttct tcgcgttcta catggtaccg 3416581 gaaaccaaag ggaaaagctt ggaggaaatt gaagcaagcc tgaaaaaacg gtttaaaaag 3416641 aagaaaagca cccaaaacca agtgctgaat gagcgtacat tataaaaaaa ggaatcgtct 3416701 ccttatgaga cgattccttt ttctgtttac accatgacct tgcaaatatt gttcgtaaat 3416761 tccacagggt cctgaatcgg caggccttcg atgaggagcg cctgattgta cagaaggttt 3416821 gtgtacaggc tcagcttctc tttatcttgt tcaaacgcgt cctgcagtgt ttggaatacc 3416881 tcgtgatttg ggttgatttc cagcactttt tccgccttca cattttggct gtcaggcatc 3416941 gcatttaaga ttttttccat ctcaattgtc acttcgccgt cagcagcaag gcagactgga 3417001 tgtgatttaa gccgttttga gattctgacg tttttcactt tgtctgacag aatgtttttc 3417061 atttcctcaa acagatcctt atacttgctt tcctcttcct cggactgctt ttgatcctca 3417121 tccgtgtcta tgccaaggtc tccgcttgat acggacttga attctttttc ctgataagaa 3417181 gccagcattt taattgcaaa ctcatcgatg tcctcagtaa agtagaggat ttcatagcct 3417241 ttgtccgcca ccatttccgt ttgcggcagt ttctcaatgc ggtcgtaaga atcaccggtc 3417301 gcgtaataaa tgaatttctg ctcctctggc attctggaaa catactcgtc taagctgacc 3417361 agttttttct cttttgaaga gtagaataag aggagatcct tcaattgatc cttattcgcg 3417421 ccaaaatcat tgtacacgcc gaatttcagc tgtctgccga acgacttgta gaacgtctcg 3417481 tatttctcgc ggtctttttt caacaggctt tgcagctcgc ttttgatttt cttgctgatg 3417541 tttttcgcga tcagcttcag ctggcggtca tgctgcagca tttctctgga aatattcagc 3417601 gacagatcct cagaatcgac catgcccttc acaaagctga agtggtccgg tagcaggtct 3417661 gcgcacttat tcatgatcag cacgccattg gaatacagct ccaagccttt ctcatattcc 3417721 ttggaatagt agtcaaacgg catgttttca gggacgaata gaatcgcgtt gtagcgaacc 3417781 gctccatcca cgctgatatg aacgtgtgtc agcggtttat caaacccgta atgcttttca 3417841 gcatagaatt tttcataatc ctcatctgtc agctcgcttt tgttttttct ccagatcggc 3417901 accatgctgt tgaccgtctg ctcttcctgc acctcttcaa attcattttc gctgccttcc 3417961 ttcggcttat taatggttgt atccattttg atcgggtagc gaatgaagtc ggagtacttc 3418021 ttgatgatcg cttttaaacg atattcctct aaaaactcgt catagctgtc atcttctgtg 3418081 ttctctttga ttttcaggat aatgtctgta ccgacagaat ccttttcaca cggctcaatc 3418141 gtatagccgt ctgcacccgc agactcccat ttataagcct cttcgctgcc aagcgcttta 3418201 ctgatgactg tcacgacatc ggcaaccata aatgccgcgt aaaaaccgac accgaactgc 3418261 ccgataatgt catgtccgtc tttcagctcg ttttcctttt taaacgcgag ggaaccgctt 3418321 tttgcaattg ttccaagatg ctgttcaagc tcatcctttg tcattccgat ccccgtatca 3418381 gagatggtta atgttctcgc atctttgtca gctgcgacct ttatgtagta actgtcttta 3418441 tcaaacgtaa gcgcatcgtc cgtaagcgct ttgtaataga ttttgtcaat cgcatcactc 3418501 gaattggaga ttaactcgcg caggaaaatt tctttttggg tataaatgga gttaatcatc 3418561 atatccagca agcgtttaga ctctgcttta aactcttttt tcgccactct tgatcgctcc 3418621 tttaccatta tgtaaaccct tttcagcatc tatttatcac ataagatgac aattgtcaat 3418681 tagattgata gatgcatata tatgtaaatt taacattagt tggatttgtt ttcactcttt 3418741 ttctcactca ttctcataaa aaagagaggc ttcatcatcc tctctttttt tctgtgtcat 3418801 tccaacggcc aaactcccgc ttcatccata tatgcaccgg gtagaaaaac aaaccgaacg 3418861 gtatcaaaaa caaaagatta tgccatgaag cattcagaaa tgcgcttgca gtcaccggga 3418921 acgtaatctc ttgcaataaa aaagagatga cagtcagcac aacaaatgca gatggaatgg 3418981 tcacgatgca ataaaacttg agctccttct tatgctgtac cttcaaacat acaaacctcc 3419041 caacaatttc taattcatct taacatatgc tggcctttct tttctcgcat gtttatcact 3419101 gcacatagcg ggaagacaaa tagaaaaagg aggtctcgta tcatgggaag acttgaaaac 3419161 aaaacagcag ttatcacagg cgccgcgaca ggcattggtc aagcgacggc ggaggttttt 3419221 gccaatgaag gcgcgcgtgt gatcatcgga gatatcaata aagatcaaat ggaagaaaca 3419281 gttgacgcaa tcagaaaaaa cggaggacag gccgaatcct ttcacctcga tgtgtcagat 3419341 gaaaacagtg tgaaagcatt tgctgatcaa atcaaggatg catgcggaac gattgatatt 3419401 ctgtttaata atgccggcgt tgatcaggaa ggcggaaagg tgcacgaata tccggttgac 3419461 ctgtttgacc gcattatcgc cgtcgacctg cgcggcacat tcctttgcag caaatatttg 3419521 attccgctca tgctcgaaaa tggaggctcc atcatcaaca cctcctccat gtcaggccgt 3419581 gccgcggacc ttgaccgctc cggctacaac gccgcaaaag gcggtatcac caacctgaca 3419641 aaggcaatgg caatcgacta cgcacgaaac ggcatccgcg tcaattccat ttcaccgggc 3419701 acgatcgaaa caccgctgat tgacaaatta gcaggcacaa aagaacagga aatgggcgaa 3419761 caattccgcg aagccaacaa atggatcacg ccgctcggac gtcttggcca gcccaaagaa 3419821 atggcaacag tggcactgtt cctcgcatca gacgacagct catacgtcac aggagaagac 3419881 atcaccgcag acggcggcat catggcgtac acatggcctg ggaagatgct gattgaggag 3419941 aaatggaagg aagaaacgaa ataagagagg gagccccctc tctttttgtc ttttaaagca 3420001 atacaacctt atatttcttc acatccaaaa actgcaaaaa ctccctcgcc agcacttcag 3420061 gcggatgcgc ctttccttca tccagccgat acaaaagcaa cccgataatc attgcggata 3420121 cataatgggc ataaagcttt ttctctgcgt gaatatcagt ttgctgatgc agataaaacg 3420181 attccagcgc tttgaacata tcaggtatca catgaggaac accccattcc cgattgagaa 3420241 aatggacaat gggcatgttt gacaaagcag aaagcagaat ggcgagcgcc ttctccgctt 3420301 cctttaagga aaattcattc gggctggagg caatcgtcag gtgatcaatg atctccgcac 3420361 atgatcgctg tatcatggtt tggagcaatt cctccttatt ggcatagtga tcataaaagg 3420421 ttgcacggcg gatattgctt ttacgcgtaa tatctgaaat cgtgatgccc gcgtagtctt 3420481 gtttctccgc caatacatcc agaaatgcct tctgcagcgc ctctctcgtt cgaaccaccc 3420541 gcctgtcgat ttgcttctcc ttctctcgct ctcctggcac agcttttcca aacagccaat 3420601 aaaaccgctt ttgagaaaca agctcccata ccttctggct gatggcttca ggagacgcgg 3420661 ccgcatcctc attcagccaa tacaggataa tcgcgtacgt gtacaaggcc cgataatgtc 3420721 cataaatgtc ccgttcaatc ggcgttaaat tcacatggat cggagccagc agcacatcct 3420781 gctgaaacac atccttaaaa aaacgatgaa aatgtcctct gttcatcatc acagaaaaaa 3420841 aggaacgatg ctcatgaaca aaggacagcg tcggatgcac cgtttgccgt tttttgttca 3420901 aatgaagggt atccatatga ctgaaggcgt caaaaagcgc tttgcccagt ccttccttca 3420961 tgtcttcgat cacatcctca atgattgaaa acttatcctc ataataaagg tagagcgatc 3421021 cgcggctcac tttggccttc tcagcgattt ctttcattgt gatgtgttga atatctctat 3421081 ctttcaataa agccagcagc gcctctttca cttgagcttc ggcagattcc ggcacaaaag 3421141 acacctccaa tcattagaca gatcttagat atatgtacgg taacgtatag atggttcacc 3421201 gttgtctttc ttacagaaaa ggtaccacct tataataggt ccgagaaaag aagaaagcaa 3421261 atgaggggga ttttacaatg gaacagcaag taaaggacga catccagcgt gtctttcagc 3421321 ttcagaaaaa acagcaaaaa gccttgcgcg cttcaacagc ggaacagcgg agagaaaagc 3421381 ttcaacgctt tttagattcc gtcatcgccc atgaagaaga aatcatcgaa gcgatccgca 3421441 aagacgtccg caaaccatat cacgaagtca aaaaagcgga aatcgaagga acaaaaaaag 3421501 cgattagaga taatatgaat aacctggaac aatggatggc gcctaaagaa gtcggttcat 3421561 cgttaagccc tgacgcaaac ggaattctta tgtacgagcc taaaggcgtc acactcatcc 3421621 tcggcccgtg gaactatccg tttatgctga cgatggcgcc gcttgccgct tctctcgcag 3421681 ccggaaacag cgcgattgtg aagctgtccg atttcacgat gaacacgagc aacattgctg 3421741 ctaaagtaat aagagacgct tttgatgaaa aagaagtcgc gatttttgaa ggagaggttg 3421801 aggtggcaac cgaactactt gatcagccgt tcgaccatat tttcttcact ggaagcacaa 3421861 atgtcgggaa aattgtcatg acagcggctg ccaaacactt ggcatctgtc acacttgagc 3421921 ttggcggcaa gagcccgacg atcattgaca gtgaatacga tctgatggac gcagcgaaaa 3421981 agatcgccgt cgggaaattc gtaaacgccg gccaaacctg catcgcacct gattacctgt 3422041 tcattaaaaa agacgttcag gacaggttcg cggggatttt acaaacagtc gtcaacgctg 3422101 gatttatgga ggatgatcat accccagacc gcagcaaatt tacgcagatc gtcaatgacc 3422161 gcaacttcaa ccgcgtcaaa gatctgttcg acgatgccat cgaaagaggg gcggaagtgg 3422221 tgttcggcgg cgtattcgat gccagcgacc gcacgatctc gccaaccgtt ttgaaaaacg 3422281 tcacgcctga catgaaaatc atgcaggagg aaatcttcgc atcgatcctg ccaatgatga 3422341 actatgaaga catcgacgag gtcatcgatt acgtaaatga ccgcgataaa ccgcttgcac 3422401 tttatgtgtt cagcaaaaac caagatctga ttgacaacgt ccttcagcac acgacatcag 3422461 gaaatgccgc catcaatgat gtcgtcgtcc atttcagtga cgtcaacctg ccattcggcg 3422521 gcgtcaacac aagcggaatc ggctcctatc atggggtata cggattcaaa gagttttctc 3422581 atgagaaggg tgtatttatt caggccgctg aataatcgca tgatcaaaag gcgcttcctt 3422641 agaggagcgc cttttattgt aactccttga ccaaaagcaa ttcatcacgg ataggtattt 3422701 tattatctgc cagtaaagga atttcgggct tcatctttct ggccgtctcg actgcattca 3422761 caaatagtcg atccaaccgg taccctctct tctgataaaa cgctaatgca tgaatattat 3422821 cattggttgt gatcagtttt atttgtttga tatttctctc tctgcatgct tcctcggctt 3422881 tctctagcag agctgttccg atccctttat tctcaatgac actatccagc gaaatgattt 3422941 cacaggcatc ttcttcaaat atgtatgtaa taaggccaac aatctggtta tcatcgttga 3423001 gcattccata accatctaat tcatcgcagt tataaatacc gctagaaata accatttgcg 3423061 gactgcccca gtgtttttga aaaaacgcgg aaacaagatc tttaggtacc tggcatgtcg 3423121 gaataatatt catattttcc tccttttagc tgaacaaaaa taagagaatt aacaacctat 3423181 tttatgtcat taatcccctt atctagtatt tactagaact tataacttgt caaaagctgt 3423241 ctgaatacca attgcgtgga ttgataagga tcaaaatctg aatcctgaga ttggaagatt 3423301 tgctctgggg tcaatgtctc tgcgttctct gataacgttt gaatcagact ttccaaatat 3423361 ccatttaact ctgatttgga cgattcatgt agggattgat gatttacagc gagttctcta 3423421 aatctgttat cactgattaa tttttttcga agagctgcta gcatcaagtc aagccatgca 3423481 ggctggccaa atgtaatatt taaagctaac gttgcttgat cagatttggt ggagtgccat 3423541 aaacctcttg gcaaatacag catggttccc ggtgttaaat taacgatttc tgcatctggc 3423601 agatcctctt ttggcggatc tcctttccaa tatgactgta aatcatcagg atagtaagga 3423661 gcctctgata aatcatagtg ctgcattgga ttgctcacat tttcattctt ggcaagcttc 3423721 catgttttct caccttgaat ttgaaaaatc aagttggtgt aggcgtcaaa atgggctttg 3423781 aatcccccgc catttttcgc cgcgtaaaca atggctttgg aagaagtacc cgcaggcagt 3423841 cttaattccg ctttgagttt ttctatccac cttctgactt ggggaataaa taggtcggtg 3423901 aaatcaaact ctaatgcagc ccctttttca taccactcta aagcctctgc aggtgacaca 3423961 agaaatctgt ctgtgatccc ttcagattct tcaatcacag catcaccaac gaccatgact 3424021 ggattattgt agatagccaa tacgttttct agcgttctaa ccttttcaaa ccccggtatg 3424081 cttgtaaatc tctccacttc tcctctggct accaaaggtt ttacaggcca atattcttct 3424141 aaaaactcac tcatcgttac aggactgatg atagactcca aaaccgattc ggttacagca 3424201 ctcatattat ccctcccaaa aaaagtaact tcaccacaaa gatataacat ttttttctaa 3424261 aagtaaatat tgacagaatt atcagaggat tataatattt agttgtgcgt gatagcctat 3424321 ttttttacaa ggaaggaggg aaaaggatga aaaaggctta taagaaacct cgtctttttg 3424381 aactgcgccg tgctgtagca gctggcggcc attaatctca tatagcattt gacatctagt 3424441 actctatttt aggagggatg ctcaatgaaa aaagcttata agaaacctcg cctttttgaa 3424501 ctgcgccgtg ctgtagcagc tggcggccat taatctcata tagcatttga catctagtac 3424561 tctattttag gagggatgct caatgaaaaa agcttataag aaacctcgcc tttttgaatt 3424621 gcgccgcgct gtagcagctg gcggtcatta atcttatcca aaacgattaa cgtttgaggc 3424681 tatcacgcca acttgataag gaggatgctg aagatgatta cggctgaaga atgcagaacg 3424741 tacaaagaat ttgttgatct ttaccaatcc tatctttacc ccttgcttgg cgccagactg 3424801 tcccggatgt attcccccaa aaacaaagtc attatcgata tgggcacagg tccaggttat 3424861 ttaagcattc agttggctaa aagaacaaat gcgcacgtgc atgctgtcga tattaacccg 3424921 gccatgcatg aaatcgctca agaagaagct aaaaaaagcg gagtaagcag cctgatttca 3424981 tttgatttgg aagatgtcca ccatttatct tacgctgacc aatatgctga cttcatcgtc 3425041 tcctactctt gcctgcatca ttgggaagac gttgttaaag gacttaaaga gtgctataga 3425101 gttctggctc cgggcggaaa aattgtcatt ttggatacat ttaatcccca aggaagccat 3425161 ttagagatta tgcgaaaaca aatcaaagaa ccggaatact tcaggtttgt aagagaggca 3425221 tttgaagaaa gttattcctt tgaagacatt caccagtttg ttcaggatgc cggcattccc 3425281 aattattcat tagaaacctt tcacttttta ccggaggatt ttatagaaag cttagatgag 3425341 ctggaggatg ctcccctgtg ggaacaaaat gatcaaagta ctgatcatga aattgagtct 3425401 gtcacatgga tgttaacgat agaaaaagaa aaggaaggtg cattgtaatg atcaatgaat 3425461 caactgtttt atccaaaaat ccagaaatgc catcaagaaa atatttgaaa agcattatta 3425521 tagagccggg catcacttta aatgaaatgg catcagatat ttataaccat atcgacggca 3425581 aggtcagcat acatgatatt tgctcaaaaa tcgtcaatga atatgatgtt gattatcaaa 3425641 cctgcttaga agattgtatg gagctgtttg agttgcttat tgatcatgaa gcaatcaaag 3425701 ttaagcaggg ggcatgagaa ttggaaaaac aaaaagtgct tgctttacca gacgatgtac 3425761 atgagctgag tacacaccgt tctaaatcaa tcgtaaatta catcatcact ctgcttgcct 3425821 ttgccaaaaa acaaggattg actcatcaag atattgtaag ctggattcac gagcaatatg 3425881 aggaaagagg atattatgat gagtggagac acattaacag ccaacaacca gttggatcat 3425941 ttgtggaact ctttataaaa ggaagacgtt tactttatga caaaattgaa ttgtttgaaa 3426001 cagaagataa atatgtcgta aatacccaca cttggtatga aaaagaacct agtgaggcct 3426061 ttttttattt tgaaattgat cccgaagaat tttctgcgta cgcttccatt ctcgcaatcg 3426121 aaaacgcaaa acgtctcgga attaaaatcg atattgtaaa agaaacagat gtagagacag 3426181 cttatatcta taaacatcaa taacgctatt gggagggaga catatgtgcg ggctcgcggg 3426241 tattataaat ctggctgctc cccgttctca ggaatgtacc tttcatatat tgaaaggcat 3426301 ggcagatgcc atcagctata ggggaccgga tgatgaacaa tatcatattg attccaaagt 3426361 cggctttgca tttcggcgat tgtccattct tgaccttgta aatggacagc agcccttttt 3426421 aaatgaggat ggatcaatcg tcgttatggt aaatggagaa atttataact ataaagaact 3426481 gaaggcttct ttacacaatc atatgtttaa aacgacatct gattgtgaag taattgttca 3426541 tttatatgaa gaaaaaggga ttggatttgt agacgacatc atcggaatgt tttcaatagc 3426601 catttgggac aaaaataaaa acaaagtatt tttagttcgt gaccgctttg ggattaaacc 3426661 gcttttttac acagagctaa aacacgagct tatatttgcc tctgaaataa aatccctatt 3426721 ttctcatcct cactgtcccc gccaatttaa ttggaaagaa gcactctcag acatttggct 3426781 aagcggggaa gcagccagta atcataaaga aaccacttcc ttttttgtaa acatccaaaa 3426841 tctcgatgct ggccattatc tcgaaattaa tttgacaaca aatgaacgaa aaacagcaag 3426901 ctattggtct ttacaggata ttttgctcag gcaaggctat cgtgagaatc tccatcccga 3426961 tgacctgatt gaaggatata gagaactgct ggcagattca gtccatagat gtttacaaag 3427021 cgacgttgaa gtcgggttgt ttcttagcgg tggcattgat tcagctgcag tcgcacattt 3427081 tgctgcagaa aaacaggatc tccatacgtt tacagtatta agccaaagta catttacaaa 3427141 tgaagatgca aaatatgccc attggctggc taaagattta caccttccaa atcatcaggt 3427201 tctctatcaa ttagggaacg atgagttatt acaaccagag tcatataaac atttgttatg 3427261 gatctgtgaa acaccgtttt gcggaccgga acaattatat aagtttcatt tacataagta 3427321 tgccaaagcg ataaggccaa acctgaaagt catgctgacc ggccagggca gcgacgaatt 3427381 taacggcggt tacagcacga cactttcacc agccgagaac ccaagttggg aaggatttat 3427441 tgaatcggtc aatacgatgg agatgaaccg gctgcatcgg ctgcagggaa atatctttag 3427501 agtgtgggag gagcattttg gactttctcc tataaacctt tcttatttaa agagcaatga 3427561 ttccagccaa gcagatcctt ggcaatcgta tgtcctgaca aaataccgtg atctgcaaat 3427621 gtataattgc tggcatgaag atcggatcgc cgcggctaat catatcgaaa accgtgtacc 3427681 gttcttggac catcggcttg ttgaatgggt ttgcggaata cctgatggac tccgtaaaga 3427741 cttgttatgg gataagtcgg tattgcgaaa atcattaaca aatgagctgc atacaagcta 3427801 tacccaccgg ccaaaggttc cttttttcta tggtaaggac gtgagatata cacataaaat 3427861 gatgtttcat cttctgaaga aaaacaatta tcagcttata gaggaggcct tctctcacag 3427921 cgatgcctcc agcataatac aggttgaaca cattcatgcc atcatgacat atttggagga 3427981 tgatcctgag tttacaaatt ttgaattttt attaagactg gtgaacatgg gacttttatc 3428041 aaaaatgact aaagaaaccc cttctgttca attagacata accagccatt tagaatcgat 3428101 aacaataaaa gactggcact cacaggaagg tgatattgcc agtcgtttaa atatctcagc 3428161 caataagtgt gaaggacaag atattttggc gctaaaccct ggcgtcactc tgttaaggcc 3428221 ggaaagcgat agtgagcatt gcatctacat tgcggaagaa ggatttattc agtttattgt 3428281 ttcggaggaa gacgtcggag cttggctgca tattctctgc gatattaatg gaaaagacac 3428341 acttcatacg attttagaca gacatggtgt cagccttgaa gaagtggcca aatatattca 3428401 agaagccatc gaacacaata tcattttgat caaacaaaaa aatctgccag aaggagcata 3428461 tagatgagca tcttttattc gttttccgca cttaggggat tagcaatggg gattttttcg 3428521 cctatttgga ttctttatct gatatctaaa gattatgatt tccttcagat tggattaatg 3428581 ggagcggtac ttgaaattgc taagcttata tttgaagttc cttccggcgt ttttgctgat 3428641 cgttatggaa ttaaaatttc aattgccagt tcattctttt tctccatcct tacatgggcc 3428701 ttcttccctt ttatcgattc agctgctatt tgcatactgg ctatgatcat atgggcttta 3428761 tcagattcct taatttccgg ttcttttgaa acttggatga gccgtgtcgc aggggaagat 3428821 cgattcggca aagaaatgat gaaaaacaca caattgctaa tcactttttt aattattgga 3428881 agtattgcca gcgggtattt gtattcatta aatatctatt ttcctttcct gctcgttatg 3428941 gtgatctact tattactatt tatttggatg tctgtattta ttaaagtccc ttctgtttcc 3429001 gaaacaaatc atggggatca gaaccaacat gattcgataa agattatcaa agaaagttta 3429061 aaaattatct ttaacaaaaa aagggttctt ttaatcgtca tagccggttt ctttacagcc 3429121 acagcctatg acacaatttc ccgttactgg cagccttttt tgagtgattt aggcttttca 3429181 gaaaagtcac tgggatatat ttttgcccta ggagggttta ccgctctcgt tcttttgaca 3429241 ttaaccatca ggttcgaaaa gaagatcgaa aaaaatccat atctcgcttt aacctcattg 3429301 gattccatgg gcatggtcat gacttttcta ttgtctagag cattcaggcc gctgggcatt 3429361 ccatgtacag cgtttttgct tgcaattgaa gatattcatc atccgatcgt aacaagttac 3429421 ttaaataagt ttttccccga ttcatacaag aacacacttt tctcgttaaa ctcaggggta 3429481 ggagcaattg gagaaattct ttccggtgtc attttcggca tcatttccgc agcctttggg 3429541 ctctctgcca tgtttgttgt tgtagctgta tttctattaa tccctattat cctttatacg 3429601 atagtgccta agattaaaga caatgatatg aaagttcaga ttgaaaaatc ccagcaagtg 3429661 taaatgtttt gtatcacagt aagaagacct tcttattaaa agaaggtctt ctgctattct 3429721 attcagttat ttcccaaaag ccatcagctt cgtataactt ccaatataaa gtgttccgtc 3429781 ctcagcgagc tgaggagaag acacgacgtt gctgtcggtt tgatagctcc ataattcatt 3429841 gccgtttgcg tctgccgcat aaaccttcat atcatctgac ccgaaataaa ccgttccctt 3429901 cgcgtcaatc agcggcgccg ttctgacagg gccgtctgtg tagaatgacc agttcatatc 3429961 cccgtttttg ctgatggaaa acagctcgcc gcttcctgag ccgatgtaga tattgccatt 3430021 atgatcaatc gcaggagatg agctggagaa cccgtttagc gggaatgtcc atttcaaact 3430081 gcctgttgat gtataagcat acagctgtcc atcttggttg ccggcataaa tgtttccgtc 3430141 cttatcaatc accggatatc ctttaaacgc atttgacgtc gttctggacc atttcacctg 3430201 tccggttccg gagttgatcg cataaaacac gtaattatat gtgccgacat acacggtgcc 3430261 gtttttggca agcaccggca cagagctgac gaccccattt gttttcaact tccagcgctc 3430321 tgtccaggtt gattttgacg tcggtttgat cgcgtgaaca taattatcaa gtgttgagaa 3430381 atacaacgtc ccgtctgaac cgatcaccgt ttcagagctt ggcccgccgc ttaacggaac 3430441 cgttgttaaa atttctcccg tttctttgtc aataaaataa atctttttgt cataggatgc 3430501 caaatagata acgccgttgg tcccaagtac aggagattgc gtatatgttt ttccaagatt 3430561 gcccgtcacc catttgactg agccgtctgg attaaaggct ttcatttccc cgtctctgga 3430621 atgaagatat actgtgccgt ctccgtcaat cacagccccc gctccatttt gcggagtcgt 3430681 tctgatgtcg ttttgccatt tcagcgtccc gtctgtattt ccggcgaacc ggctttcgcg 3430741 tgaccagtta aacatggcag gcgccatcgc ttgtacatca tatcttcctg gcaaaaagcc 3430801 agatgctcca ttattttgag aaaacaccgt ttccgccgca taagcagctg tcggctgaag 3430861 cactttggca gcgggcacat cagaaacagc gccggccgaa acagccgccg ccaccgcagc 3430921 tcccgcaatc aaagctttca tacgaaatga cttgaccatc attgagaccc ccattatatg 3430981 taacttctaa tttgtgacca tcataacata ttcatccatt ttataaatct atttcacaaa 3431041 aacatcacaa actagaaaac tatgtaagag tattcacgga cgttttttca gcacccgatc 3431101 gaaatgcagc cacaaaccaa atgacgttga cagcagccgc agcgagacta actcccaaaa 3431161 caaagatcac ctcagaaagc agatggtcac taaagaaact aaacatcaag ataaaaccgg 3431221 ccgaagacaa atgaatcaaa agcccgaagc cgcaaagcac cgccatgaca tacctcattg 3431281 catcgactcc gagcatataa acgagaaatg gaatgaaata caagacaagg atcataccga 3431341 cagctgacca catgccagct gaattaaact gattggccgc cgctcccgtt ccggccagcg 3431401 gcgaaagtga agccgccaca atcacggcgc aaaaaagaaa cgcagaaatg gttgtcatga 3431461 tcgccacgct attttttttt gacatcaaac tcctccttta atagaaatat taaccttttt 3431521 tattataagt aagttgaatg ttatattcat tatattttta aaaaattcca gaatacatac 3431581 acaaatgcta tgcttctttc tagtatattt atatagtaaa aaacaaagga taaaagactc 3431641 atttttctgt aatatcagga ttttatcacc ataccatatt gcatgtacat gtttttcaaa 3431701 gtatactatt ccagattaat tcagaggaga gagaaaaata catggaaaaa ccagcaggat 3431761 tttggattcg ttttttagct tattttattg acggcattat tgtatctgtt cctagttata 3431821 ttattctatt tattatcaat tctgtgtttg tagctggggc tgtggcaaca aacccttaca 3431881 tgacggaaga agagtattta gtgaaataca tgacgcttgc atttttgcct actatgctga 3431941 tcatgatcgt catcagcgtg ttatattacg ggctgctcac agcttctaaa atgcaaggca 3432001 cacttggcaa aaaaattctt ggcctgaaag tggtcaatga acaaggtgaa cgggtttctg 3432061 tcggacaggg aattggccgt tactttgcct atatcttatc tggaatcatc ttttatatcg 3432121 ggtttatcat gatcgccttt ggagagaaaa aaggcctgca tgacatcatt tgcaaaacac 3432181 gtgtcgtgta taaataatag aaaaaagtct agacgccaat aggcatctag acttttgttt 3432241 tctttgcaat aggctgccac gacagatacg tagcgcttct ccacaaccac tcaaacggcc 3432301 ccatccgaaa gacacgaagc caaaggtggc tgaagaccat ttgaacggca caaacagcaa 3432361 ttgtaatgag cacaccggca gcagggtaca cttttccata caggcccaag ccgtaatgat 3432421 aaaaaatcca agtacacaca atagactgca tcaaataatt ggtaaatgcc atcctcccaa 3432481 cagcggagaa tgattgcagc actgttctca ctcttgtttt atgataaaga tagacaaccg 3432541 ttgtaacata gaaaaacatg aggaaaggcg cgccaatcag caaacatatt tctttatccg 3432601 ttacactgta cagcacctgg gcgccgatgc cgatgacaag cccagccatc cataatcgtt 3432661 ttaatccttt gcgatgcttt tccggttcat gcaaataccg tgattttgct gccgcagctc 3432721 ccagcaaaaa catgctgaaa tatggaatgg atgcaaagaa gtagttgagc ggattatacg 3432781 taagcatgcc attcgaagac atgtaaacaa gacggtcgtg gatccgctgt tctgcaatat 3432841 ccttcaggct gccgcttcca taaacatgaa tcgcttgttt tgcctgctgt gttaccgctt 3432901 gtacccattc ctgtccgttt gattgatcaa aacttgtcaa catgaacgga atggaaaaca 3432961 gaagatacaa agagaccgcc catatcagca gtgttttcgg ctttgctttt cgaaacaaga 3433021 gcaggacaaa tccgagcagg gcatattctg ttaaaatatc cccgtcccat atcaaaaagg 3433081 catgaatcgt tccaaacaag agaagcgcca ttaaccttct cacatataac ggaacaaacc 3433141 gtttcccttt gttttctgct ctctccatca tgacaaccat gccaaatcca aataaaaagg 3433201 aaaacaataa aatacatttt gtttgaatga agaatttcag tatgtctgcg gcggcaaaat 3433261 cagcttcaga ccacttatcc atgaaaaaat tctcttttcc aagcatagac aaatacatat 3433321 ccggataact gaaatgtgcc agattgacaa ataagatgcc gaaaatcgcc attcctctca 3433381 gcacatcaag cacaccgatc cgctcatttg ttaaagtcgg ctgtaatgaa gacatagcca 3433441 tcacgctcct tttttctgta ccttaagggt aggaaaaaat gaagcgcggt aacatcgatt 3433501 taggtgtcag gccggcatga aaaccttaca atcttgtcat ctttatggtt tcatcacctt 3433561 taaatctaat gcttcgatat tctgcaaaat gcgatcaaag cgcaaagcct gaggctcaca 3433621 tgggaagatg tggccttcat acgggtcgcc taacgtccgg aaaaacggtt caaataaacc 3433681 aggaaccaat acgcccacca tctttgtata gtgagaatca aggcgatagg agtgaacggt 3433741 atttgcaggg acatgcagga aatctcccgg attcagctga atttcctggc catctgtcca 3433801 catcgtcatc tggccttcaa ggcaataaaa tgtttctgta tgatattcat ggtagtgatc 3433861 aacgattcgg tcacctttag ggccttcaga tgatacgacg ataaactggc catctgtatt 3433921 tttttgtgca gccacaatgc ggtgaagctg atctccagtc aacagacgat ctccttctcc 3433981 agattcaaga acgtatggaa ccgctccatc tggcagctct gtaagttccg ctaatttggc 3434041 cgaacatgca ggctttgctt catctagaaa tacaatgtcc gctacagcgg ctgcttctgc 3434101 aaatcgctcg tttgagactt cttcgcttgc gtacggcgga tgttcagcgt gatcatacgg 3434161 attcccaata acggaataca agtgcgctac gtttcctttc atcgtgtaag acaccagtct 3434221 tgttctgtgg ctctgcatcc ggtagctgtg cggtgttccc gccggaatgt tggcataatc 3434281 acctgatatt aataaatagc gttcaccatc aagtgtcagt tccagtttcc cgtccaaaac 3434341 gagaattcct tcatgtgtgt ccttgtggac gtgaagcgga aaggcatctc cttttccccc 3434401 ggaaagaagc acgatctcaa acaaatcacc tgtgctcctc ccattcgcca tcaccgtggc 3434461 aacctgtctg ccgaacagat agcgctcgcc ttctccgctc cggagcaaat aaggcatttt 3434521 ttctttaggc aatgaatgtg tacataatgt tttcatatta tcgcttcctc caatttagac 3434581 cagtctatat attatcattc atttgtctag accgttctat ataattgtag gagaaaggat 3434641 aacaaaatgc tacccttttt ttctcaccag cactggtatt tgttcggcaa tgagaagaag 3434701 aggcgttttg tctttattcg ttaacgaaag catgatgccg ccctcaatca tcgaattaat 3434761 cagcgttcca agctgatttg cttcttcttc tgcaaatccg ttttccatta attttctggc 3434821 aaaaaccgct tcccagcttt taaacacctt catgcaaacc gtccgcagcg gttcactgat 3434881 taacgctgtc tcactcgcca gcaaaccgac tggaatacct ttaatgcttt ctgtgttgtc 3434941 aaattggctg gctgtttttt tgataaaaag ctgaatcgct tcaacaggat cagaggattc 3435001 atccatgctt tgctgtatca gatgttcaac gatcttacct gtatatgtaa ccgcttcaat 3435061 tgctagttct tctttgccat tcggaaaaaa gtgataaagc gatccttttg gagcaccgct 3435121 ttcttttaca atctggttca aacctgtcgc gtgatatcct tgcagctgga acagacgtga 3435181 cgccgtgtga aggatttttt cacgtgaatc tcctctgcta gtcattaaaa cattccctcc 3435241 taggtatggt agagcgactt atataatata aaaaagaacc ctgtgattgt caaaaggggt 3435301 aagacccttc cggatggggt aatgtacaaa aacagcgtct aggagggatc tctcaatgac 3435361 aatcgatcat tcagtcacaa atacagagca gcttgaacaa cagaaccccg ccataaaaac 3435421 aaagctcaaa ctgaaaaagc ttaaggatca ggtgatcgtc attaccggcg cttcaagcgg 3435481 tatcggactt gtcacggcga gaatggcagc tgaaaaaggc gcaaaggtcg tggcagcagc 3435541 gcgaaatgaa gaggcgctga aggagctcac tgatgaactt aaggaaaaag ggcacgacgc 3435601 catatgggta aaggcggatg tcggaaaaga agaggacgtc aaccgcatcg cagaaaccgc 3435661 gatcagcaca ttcggccgct ttgatacatg ggtcaacaat gcggccgtct cgactttcgg 3435721 acacgccatg gacgtcaccg tcgaagacat gaagcgcatg ttcgacacaa atttctgggg 3435781 acctgtttac ggaacaagag cggctgtcaa acactacacc ggcagaggtg tgccgggcgc 3435841 actcattaat gtaggaagcc tgttcggaga caggggaacg gtcattcaat ccacatatgc 3435901 atctgccaaa tttgcgcttc acggctggac ggaaagcatc cgaatggagc ttgaaaagga 3435961 acaggcgccc gtctcggtaa cgctcatcca cccgggcaga attgacacac catataacga 3436021 gcatgcgcac agctacctcg acaaacagcc ggctcattac cgctccatga tctatccgcc 3436081 ggaagcggtc gccgaagcga tcctgtttgc cgccgaacac cctaagcgcg acatgtacat 3436141 cggctcacag gccaaagcca tcgccatgct gggcgcgctt tttcctcgtc tgaccgacag 3436201 actgatggaa aaaatcatgt atcacagcca gcatgccgaa agaccgtcca atccgagaga 3436261 agaaagcgct ctttatgatg ctggctgcgg tatgcatgac agaggcacaa ataaaggatg 3436321 gatgaggtca agaagctact acacaaaagc gacgaagcgc ccaattgtat cggcggctgt 3436381 tgttgccgga ctagtggctt gggctgccgc caaacgatgc agataatctc tgaccataag 3436441 aaaaacccat gctgttccag cgaaccatgg gtttttcagc tgttaatcga taaaagcctt 3436501 gttcatacgc tgcagcagct cgccgaacat ctctttttcc tgtgttgacc attctttcag 3436561 catctgttca taacgttcaa ggcgcttttg ctgatcggct tttaatagtt gtttgccgag 3436621 ttttgtaatg gtaaacaggc tgactctccc atcagacggg tctgagaaac gatagatgag 3436681 ctcctttgcc tctaatgcag ctgcttgtct tgaaagagta gaaatatcaa gcttaaacga 3436741 ttcagccaat tccttaacac gagcaggccc aaactcatcc aattgtctca gtaataagta 3436801 cgaagatctc tccaaattcc ctgttctttt ctccgattga tccagataaa cagctctcct 3436861 gataaaagtc gtcagctcat attcaattaa ttcaactgga ttttgatttt gcaatcgctc 3436921 tcgctcccta ttccaatctc cggcattgac aacatcatat atacttgtat aatacaaatg 3436981 tacattaact gaataaatac aagtcgttat atgactaaat caattattat acttgtatag 3437041 tacaatcata taaaaagaaa gtaaagcgat tcctcagaac catcctagaa gcaagcacca 3437101 gaaaggagga agctgttctg attggagagc agcacttgat gtgaaagtca tacgaattat 3437161 tttgcaagtg ttgatattat atgtattttt tatgatcggg gaagccattc agcatctgtt 3437221 tcatttaccc gtgtcaggaa gcatcgttgg attggtattg cttctgatct gcttgggcct 3437281 ccgtattgtt cccgtctcca tcattgaaga cggagcaggg tttttattat ccttccttcc 3437341 attgttgttc atcccggcaa tgacaggagt gataaactat ccgtctctca tttcattcaa 3437401 tggcctgatg ctgctgatta cagtcgttct cagcaccatc gtcacgatca ttgcggctgg 3437461 attcgccagc cagctattag agaaaaaagc aaaaaaacgg gaggagaaag agaaatgcag 3437521 caagcatgta tcgcgatcat tataattctt ttaacagttg ccgcttattt agcgatggtc 3437581 aaactctata agcgattccc gcttccattt ctgatccctg ttctgacaac gacaattttg 3437641 attgtagcgg ctttgatgat gtttcatgtt tcctatgaag gctatatgat cggggggaaa 3437701 tggatcaatt ctttgcttgg gccggctgtt gtggcgctgg cctatccgct ttataagcaa 3437761 tggcatatca ttgtcaaaca ttgtgttccc attttaggcg gcgtcctggt cggcttatgc 3437821 atgggaatga tcagcgggct gatcttcgca gaagcattcg ggattgatca tgatctctta 3437881 ttatccattc tgccaaaatc gatcacaacc cctgtcgcta ttcagatcgc cgccggtctt 3437941 ggcggcgtcc cttccatgac agtcgtattt gtcatgattg cgggcttttc aggcgtcatc 3438001 ctcgggccgc ttttcctaaa atggcttcgc atacgcagct ccctaggaca aggcattgca 3438061 ttaggcagcg cctcccatgc actgggtacc tccaaagcgt tggaatatgg ggaattggcc 3438121 gtatccatga gttccgtctc catgacgctt tgtgcggtgc tcggctcatt cttcggcccg 3438181 ctcgtcgtct ggctgtttca tatttaacaa agaaagactg ccccggggga gggcagtctt 3438241 tttcgtttaa gaagcaaaaa aatcaatcaa cggctgaaag tccttagata aatcaacgtc 3438301 attcggttct gcttgaagca ggcggtcaat catacgctcc agctcctcaa catcattctt 3438361 atccgtatat tcaatgaagt ttaagctttc aagccaatcc cgatatgaat gtttggcttt 3438421 gccatagctg tttccaaaga caaggcaagg tgttttggtg ataatcgaga aaatcatcgc 3438481 gtgaaggcgg tcggtaatca ccaatttact ggagccgatg cggtccagca tctccataaa 3438541 atgcttttca cgatcagcgt aatcgatggt gtctaccgta tccagcaccg tatcggtacg 3438601 ctctgtgtaa gttgtttttt ctgcccattg cttcatctgt gaaataaaat cttcgtcagt 3438661 cactttctcc ttatccgctc ttaaaataaa gagaacgccg tcccgctcga gctctcgcgg 3438721 cacaatatcc aaggaaagca ccatgtccgg tgtaaagatc acattggagt tgaaggtctc 3438781 tttcacaaca tccagtgttt gcgtctcacg cgcagcaatc gttaagtttg tattttgatg 3438841 gtacgcatcc tgtgtttttt tcttttcctt ctgtccttcc tctgtatcct caaaataaac 3438901 ggattgtggc agagaaattg atttgtagtc tttaaacgcc gaaaagacct ttcttctgtc 3438961 ttcctcaata tcgagataaa ggtttcctaa attccctccg cctgtaaagc agacaatatc 3439021 gtcttcacga atgatctcct tcaccagttc aatgccctca tccgtcgcat aatccataat 3439081 ctcaatgtat tcataatacg gaaaatgatt tttgataaat ttctcttccg catacgcaat 3439141 cgcttggtcg ccaatgtttg tgtagctagg ggaaccaaac aaaaatactt ttcgtttatc 3439201 atttaacaga gcttccggct ccacatttgg cgcaatgcct tttactagtt ttttgccttt 3439261 gatttcttgt acagtcatat ctgcgtcctc cttctgggat gaattcctca ttgtgtgtta 3439321 actgtctcta cccaaaaaga aggatggcta tgcattggca tgtgcatcgg ctatatcaga 3439381 aacatcgttt tcgccaattt gatagacgct gcaatgtccc gcgccgttct ttccatatat 3439441 tccgcggcat gttcaaacgc gtcttctagt ggcacggctc cggggacgat gctgaaaagc 3439501 gcatcgattc cgtgttgata gacggcatta ctgtctcggg aaattgatcc cgcaatgccg 3439561 ataacgggca catcgtatga tttagcggcc ttggccaccc cgatcggtgt ttttccatga 3439621 accgtttggc tgtcgattcg tccctcgccg gtaatcacaa ggtctgcatc ctgaacgata 3439681 ctttcaaaat caaccgcttc aaggacaata tcaatgcctc ttttcaggtc agcctgaaga 3439741 taagttagca ggctccatcc aagaccgccc gctgcaccgg cgccctctgt atctcggaag 3439801 gttgatccga gcgctttttc tgccatatca gcgaaatggc ttacgttctg gtctagtaca 3439861 tccaacatgt cggccgtcgc gcctttttgc ggcccgaaaa cagccgtagc accctttggt 3439921 cctgttaacg gattgtccac gtcacaggca acttccagtt tgacattccg caatctggaa 3439981 tcaagcccgc tcacatctat tgatgcaagc tgagataacg cgccgccccc tgggccaatc 3440041 tcgctgcctg agttatcaag aagccttccg cccaatgcct gaatcatccc ggctcccccg 3440101 tcgttcgtgg cgcttccgcc gattccgatg atcaatcgct ccgctcccgc atcaagagct 3440161 gctccgatta attctcccgt tccccttgtt gtagtgatga gcggatttcg cttatctaca 3440221 ggcaccagat gcagccctga agcagcagcc atttcaatca cagctgttct cccatctccc 3440281 atcatgccaa agaaagctct caccggttcc cccagcggcc ctgtgacaac ttgctctatg 3440341 atccttccat tggtcgcatc gaccagagat tgaacggttc cctcgccgcc atccgccacc 3440401 ggcaattttc tgtaatcagc acccggaaag accgatttga aacctctttc tatcgcttcg 3440461 gctgcctcca gagctgataa gctttcctta aaagaatcag gtgcaatgat gattttcatc 3440521 caaatcgcct ctttcaaaac atgattcact taacctattg atctccaatg taccataatt 3440581 gatctggaaa tacataccat gcaatatggt aaaaatttaa ataaaaatta gaaatgaaag 3440641 tgtttgcata aaagaaatat tcacgttatc atacttgtat acaagtatac tccttgagtg 3440701 aggaaggtga gtgtatgcta gactccaaag acctgttgta tcccgcaaaa tggctctcaa 3440761 aagcgtcaac cggagttcgt gtcgcatacg agctgagaat gcggatcgtt tcaggtctga 3440821 ttgaaagcgg taccatttta tcagaaaata caatcgccgc cgagttttca gtaagccgtt 3440881 cgccggttcg cgaagcgcta aaaatactcg catccgaaaa aatcatccgc ttagaacgaa 3440941 tgggagcggt cgtaattggt ttaactgaga agaaaatcgc ggaaatttat gatgtgcggt 3441001 tactattaga aacatttgtc tttgaacggc ttgtcaaaat agacattgag cctttagtta 3441061 aggatctcag caaaattctt gaaatgatga aagtctcaat caaatatgag gatgctgacg 3441121 aattttcatt tcaagatgtg ctgttccatg aaacgattat ccgagcgatt gatcattcat 3441181 acattcagat gatctggaac aatctaaaac ccgtcatgga aagctttatt cttttatcga 3441241 tgcgggtacg gttaaaggaa aagtatgaag acttcacaag gattttagat aaccacgagc 3441301 tttatattca agccatcaaa acaaaggata gggcgctgat gattcagtct cttcaccaaa 3441361 actttgatga tgtgcaggat aaggtagaag acctatggct ctcacaacaa atgctggcaa 3441421 aaggagctga atacaacaat gactagttat atgttaggaa tcgatatcgg cacgacaagc 3441481 acaaaagctg tgctgttcag tgaaaacgga gatgtggtac agaaagaaag catcggctac 3441541 ccgctctata caccggacat ctcaacagct gaacaaaatc cggaagagat ttttcaggca 3441601 gtcatccata caacagcgag aattacaaaa cagcatcccg aaaaacggat ctctttcatt 3441661 tcgttcagca gcgccatgca cagcgtcatt gcaatcgacg aaaatgacaa gccgctgacg 3441721 ccatgcatta catgggccga caacagaagt gaaggctggg cgcataagat caaagaggaa 3441781 ttgaacggac atgaggtgta caaacggacg ggaacaccga ttcatccgat ggcaccgtta 3441841 agtaaaattg cctggatcac gaatgaaaga aaagaaatcg cttccaaggc aaaaaaatat 3441901 atcggcatca aagaatacat ttttaaacag ctgttcaatg agtatgtcat cgattactca 3441961 ttggcatcag cgacaggcat gatgaacctg aagggcttgg attgggacga agaggcactg 3442021 cgcatcgcag gcatcacgcc ggatcactta tccaaactcg tgccgacaac cgagatcttt 3442081 cagcactgca gcccggaaat agcgatccaa atgggaatcg atccggaaac gccttttgtc 3442141 atcggcgcca gcgacggcgt gctgtccaac ctcggcgtca acgccattaa aaagggtgaa 3442201 atcgccgtca ccatcggtac aagcggtgcc attcggacga ttattgacaa gccgcaaacc 3442261 gatgaaaaag ggagaatttt ttgctatgcc ttgacggaca agcattgggt tattggggga 3442321 cctgtgaaca atgggggcat cgtccttcgc tggatcagag acgagtttgc ctcctccgaa 3442381 atcgaaacag cgacacggct gggcattgat ccatatgacg tgctgacgaa aattgcccaa 3442441 cgcgtcagac ccggttctga cggtctgctg ttccacccat atctcgccgg agaacgcgct 3442501 ccgttgtgga atccggatgt acgcggctca tttttcggct tgaccatgtc gcataagaaa 3442561 gagcatatga tacgcgcggc attggaaggc gtcatttaca acctgtacac ggtgttcttg 3442621 gcgttaactg aatgcatgga tggcccggta acccgcatcc aagcgacagg gggttttgca 3442681 aggtcggagg tttggcgcca aatgatgtcg gatatcttcg aatcagaggt tgtcgttccg 3442741 gaaagctacg aaagctcatg tctcggcgcc tgcattttag gcctgtatgc aacaggaaaa 3442801 atcgattctt tcgacgccgt gtccgatatg atcggcagca catacagaca tacgccgatc 3442861 gaagactcag ccaaggaata cagaacatta atgccgattt tcatcaatct atcaagatta 3442921 ttagaaaatc aatatacaca aattgcagat tatcagaggg gcttaatcac acacaaatag 3442981 tacatgacat gaaggggagg gcattaccat gccgttaatc atcgttgcac ttgggatctt 3443041 agcattacta tttctgatta tgggcttaaa attaaacaca tttatttccc tgctggtcgt 3443101 atcgttcggc gtggcactgg cactcgggat gccgttcgat aaagttgtca gctccatcga 3443161 agcaggaata ggggggactc ttggccacat cgcgctcatc ttcggactcg gtgcgatgct 3443221 gggcaaactg atcgcggatt caggaggcgc acagcgcatt gcgatgacgc tcgtcaacaa 3443281 attcggtgag aaaaatattc aatgggccgt tgtcattgcc tcattcatta ttgggattgc 3443341 gttatttttt gaagtaggac tggttctatt aattccgatt gtctttgcga tttcaagaga 3443401 attgaagatt tctattttat ttctcggaat cccgatggtc gcggcactat ccgtcacaca 3443461 cggtttcctg ccgccgcacc cgggacctac ggcgatcgcc ggtgagtatg gcgcaaacat 3443521 tggagaagtg ctgctgtacg gctttatcgt tgctgttccg acagtgctca ttgcagggcc 3443581 gttatttaca aagttcgcga aaaaaatcgt tcctgcatca tttgcgaaaa acggcaatat 3443641 tgcatcactc ggcacacaaa aaacatttaa ccttgaagaa acacccggct ttggaatcag 3443701 tgtctttact gcaatgctcc cgattatcat catgtcggtc gcgaccatta tcgacctgct 3443761 tcaagaaaca atcgggtttg cagataacgg agttttagct tttatcagat tgattggaaa 3443821 cgcatcgact gctatgatta tttcgttatt ggtcgcagtc tatacaatgg gcatcaagcg 3443881 caacattcca gtcaaaaccg tgatggattc ttgttcaact gccatttcac aaatcggcat 3443941 gatgcttttg atcatcggag gaggcggcgc cttcaaacaa gtgctgatca acggcggtgt 3444001 cggcgattac gtagcagact tattcaaagg aacggcatta tcgccaatca ttctggcatg 3444061 gctcatcgca gcgatcctgc gcatttctct aggatcggcg actgttgccg cactaagcac 3444121 aacaggtctg gtcattccgt tattgggcca ttctgatgtt aacctggcgt tagtcgtact 3444181 cgcaacagga gccggaagtg tcatcgcttc acacgtcaat gacgccggct tctggatgtt 3444241 caaggaatac ttcggattaa gcatgaaaga aacattcgcc acatggacat tgctggaaac 3444301 cattatttcc gttgctggac tgggattcat tttattgtta agtttagttg tatgaaatta 3444361 agaaggagct gtaacacatg ttcaattcga ttggtgtcat aggcttaggc gtaatgggaa 3444421 gcaacatcgc cttaaacatg gcaaataaag gcgaaaacgt cgctgtctat aattacacca 3444481 gagatttaac ggaccagctt atccaaaagc tggatggaca atctctcagc ccgtattacg 3444541 agcttgagga ctttgttcaa tcgttagaaa aaccaagaaa aatctttttg atggtcacag 3444601 cgggaaaacc cgtagattcc gtcatccaat cattaaagcc tttgcttgaa gaaggcgacg 3444661 tcatcatgga cggaggaaac tcccactatg aagacacaga aagaagatat gacgagctga 3444721 aggaaaaagg gatcggctac ctgggagtcg gcatttccgg cggtgaagtc ggtgcgttaa 3444781 cagggccttc catcatgccg ggcggagatc gcgacgtcta tgagaaagcc gctcctatcc 3444841 tgacgaaaat cgcagcccaa gtcggagatg acccttgctg tgtctatatc ggaccaaaag 3444901 gggcagggca ctttacaaaa atggtgcaca acggcattga atatgccgac atgcagctga 3444961 ttgcagaagc ttatacgttt ctaagagaaa cgcttcgtct gccgctagat gaaattgcat 3445021 ctatttttga aacatggaat caaggtgagc tgaaaagcta tttaatagag attacagctg 3445081 agattttacg caaaaaagac gaaaaaacag gacagcctct gatcgatgtc atccttgata 3445141 aaaccggcca aaaaggcacc ggaaaatgga cgagcatgca ggcgattgat aacggcatcc 3445201 cgtccacgat catcacagag tccttgttcg cccgctactt gtcatcttta aaagaagaac 3445261 ggatggcagc tcaagatgta ttagcaggcc cggaagccga agaaaaacac ttggataaag 3445321 acacttggat tgaatacgtc agacaggctc tttacatggg gaaagtatgc gcctatgcac 3445381 aaggctttgc ccaatataag atgtcatctg agctttacgg ctggaatctg ccgctcaaag 3445441 acatcgcctt gattttccga ggcggctgca tcatccgcgc tgatttccta aacgtgatca 3445501 gcgaagcatt cagtgagcag ccaaatctgg ctaacctgct gatcgcgcct tatttcacag 3445561 ataagctcca tgcctatcaa acaggcctgc gaaaagtcgt ttgcgagggt atcagcaccg 3445621 gaatctcttt cccatgctta actaccgcgc tctcttatta cgacggctac cgcacagggc 3445681 gttccaatgc gaacctcttg caggcacagc gcgattactt tggcgctcac acgtacgaac 3445741 ggactgatat ggacggcgtc ttccatacga attggtctga ataacctgta ttaaaaacac 3445801 ggtcagtttc aactgaaccg tgtttttttc ttctatccca aacaacagaa gacataagtt 3445861 atgttttaaa tatcataaac agtgatacaa taatagctag aaacaatccc caagatcatc 3445921 atgtgacagc agattgctgt tccgttctat tctgcttttg gccattgtcc tttgcccttg 3445981 accatggtgt cataaaatgt tcaaatgcca aaacggcctg gcattctgat ttacaaaagt 3446041 ccctgaaaac cttatctaat tgagaatcag cctctcattt attataaaag aaatgcctaa 3446101 atcctacctg tcacaccttt attaagatga aaaaaagtag gttatggctt gacaaaaaat 3446161 atatattaat taataattca tatataatta gaattattat tgaaagcgat tatgctttct 3446221 aatacatttt taggaggaat atacattatg tctttaatcg gtaaagaagt acttccattc 3446281 gaagcaaaag cattcaaaaa cggtgaattc atcgatgtaa caaacgaaga tttgaaaggc 3446341 caatggagcg tattctgctt ctacccagca gatttctctt tcgtatgccc aactgagctt 3446401 gaagatcttc aagaacaata tgctgcactt aaagaattag gtgttgaagt atactctgtt 3446461 tctacagata ctcacttcgt acacaaaggc tggcatgaca gctctgaaaa aatcagcaaa 3446521 atcacttacg caatgatcgg tgacccatct caaacgatct ctcgcaactt cgatgttctt 3446581 gacgaagaaa ctggccttgc tgaccgcgga acattcatca tcgatccaga cggcgttatc 3446641 caaactgttg aaatcaatgc aggcggtatc ggccgtgacg caagcaacct tgtaaacaaa 3446701 gtaaaagcag ctcaatacgt tcgtcaaaac ccaggtgaag tttgcccggc taaatgggaa 3446761 gaaggcggcg aaactcttac acctagcctt gatctagtag gtaaaatcta aggagtgcat 3446821 tcaattggta cttgatgcaa atatcaaagc acaattaaat caatatatgc agctaattga 3446881 gaatgacatt gttctcaaag ttagcgcagg cgaagatgac acttctaagg acatgctggc 3446941 tctcgttgat gagctggctt ccatgtcatc gaaaatttca gttgaaaaag ctgaattaaa 3447001 cagaacgccg agcttcagtg tcaatcgtgt cggagaagac actggcgtga ctttcgccgg 3447061 tatccctctg ggccacgaat tcacatcatt agtgttggcg ttgctccaag tgagcggcag 3447121 accgcctaag gtagaccaaa aagtcattga tcaggtgaag aagatcagtg gtgaatacca 3447181 cttcgaatct tatatcagcc tgacatgcca caactgtcct gatgttgtac aagctttaaa 3447241 catgatgagc gtgctgaacc cgaacattac gcacacgatg attgacggtg cagcatacaa 3447301 agcagaagtt gaaagcaaaa acatcatggc agtgccgacc gtttacctga atggcgaatc 3447361 cttcggaagc ggccgtatga cgcttgaaga aattcttgcg aaaatgggca gcggcacaga 3447421 tgcatctgag tttgctgaca aagagccgtt tgacgttctt gtggtcggag gcggacctgc 3447481 tggtgcaagt gcagcgatct acactgcacg taaaggcatc cgaactggtg ttgtcgctga 3447541 gcgcttcggc ggacaggttc tcgacaccat gagcatcgaa aacttcatca gcgtcaaagc 3447601 gacggaagga ccgaagctag cggcaagtct tgaagagcat gtgaaggaat atgatattga 3447661 tgtcatgaac cttcagcgtg cgaaacgcct tgagaagaaa gatctgttcg aacttgaact 3447721 cgaaaacggc gctgtcctga aaagtaaaac agtgatcctt tcaacaggtg cacgctggcg 3447781 caatgtcaac gtccccggtg aacaagagtt caaaaacaaa ggtgtcgcat actgcccgca 3447841 ctgtgatggg ccattgtttg aaggcaaaga cgttgcggta atcggcggcg gaaactctgg 3447901 tatcgaagca gcgattgatc ttgcaggtat tgtcaatcac gttactgtac tagaattcgc 3447961 gccggaactg aaagcagacg aagtcctgca aaaacgtctc tacagcctgc ctaacgttac 3448021 tgtcgtgaaa aacgcacaaa caaaagaaat cacaggtgat cagagtgtta acggcatcac 3448081 atatgtagac cgcgaaacag gcgaagaaaa acacgttgaa cttcaaggtg tattcgtcca 3448141 aatcggtctc gtgccaaaca cagaatggtt agaaggaacg gttgaacgca accgcatggg 3448201 cgaaattatt gtcgacaaac acggcgcaac aagcgtacca ggcttatttg ctgccggcga 3448261 ctgcacagac agtgcgtaca accaaattat tatttctatg ggatcaggtg caactgccgc 3448321 cctcggcgcg tttgattacc taatccgtaa ctaatataag aaatccgcta tattgccaga 3448381 ttggcaggat agcggatttt tctttttcta cagaaaaaaa ccgaaccagg cactacggta 3448441 aaagtgctcg attcgagcgc ttcttatagt tcctcaccat tcgtttgaat gacattttta 3448501 taccactcaa aggagtcttt cttatatcgt ttcatggatc cgtttccttc attgtcacga 3448561 tcaacataga tcatgccgta gcgttttttc atttcgccag ttgtgaagga gacaatatca 3448621 ataatgcccc acggcgtgta gccaattaaa tcaacaccat cgtacgtgac cgcttttttc 3448681 aatgcttcaa tatgcgattt taaatattga atgcgttccg gatcatgaac cttgccgtcc 3448741 tcctccagcg tatccactgc gccaaagcca ttttcaacga tgaataacgg gatttggtat 3448801 cggtcataaa aacgatttaa cgtatatctc aacccggttg gatcaatcgc ccatccccag 3448861 tcactcgaag tgatgtacgg attttcgaca ccattcggca agccgccatt tacaatatcg 3448921 ccagtgttat catttttcac atcgcttttc acagttgttg acatgtaata gctgaagcct 3448981 aagtaatcga cggttccgtt tcttaaaatc tcatcatcgc cgtcttcgaa tgtgatgttg 3449041 tagccttcgc gttcaaattc cttcaacgcg tagcttggat aataaccgcg aacctgcaca 3449101 tcagggaaga aatagcgctg cctcatttct tcttcagcca gcatcacatc ttcaggattg 3449161 gaggagaaag gataaatcgg cacgtgtgat accatggccc caatctggaa ctctggattg 3449221 atgtcttttc cttttgccac tgctaaggcg ctcgccacta attcatggtg cgccgtttga 3449281 tacatgactt ccttggcgtt ttcgttttcg ccaaccacaa cacctgaatt cgtccatagg 3449341 aacagcggat tgttcacatc catttggttg ttaatctcgt taaatgtcat ccagtacttc 3449401 actttatctt tgtaacgggt aaagcaagcc tctgcgaagt tgacgaagaa gtccacgact 3449461 ttccggtttc tgaagccgcc atattctctt gccaggtgca gcggcatttc aaagtgagac 3449521 agggtaatga ccggctcgat cccatgcttc agcaattcat caaacacatc atcataaaac 3449581 tgcaaaccag cttcgttcgg ttcagcctca tcgcctttcg gaaaaatccg gctccagccg 3449641 atggacgtcc gcagacattt taatcccatt tccgcaaaca aagcgatatc ttccttgtat 3449701 ctgtgataga aatcaatggc ttcatggttt ggataaaatt cgttttcttc aatcgtgtca 3449761 gtgatttttc tcggcacgcc gtgcgcaccc gctgtcatca catcgacgac actcggccct 3449821 ttaccgcctt gattccatcc gccttcaaat tggtgggcag ctaaagcacc gccccataaa 3449881 aaatcctttg gcatgtttcc catgtttaat tcctcctcag cttacgactg taaatatttt 3449941 ttgatgtaat gcactttcct caatgtcttc aatgaaagct ttatcaaact caacaagcac 3450001 ttcgcctttt ttgacggtat cgccttcttt taccttcaag gaaaaaggcg tgccgtcaaa 3450061 tgtcaccgta tccagcccga tgtgcgcaag caattcgacg ccggacgctg aacgcaggcc 3450121 aatcgcatgc tttgtaggcg taaccatgac aaccgtaatg acgccgggat ggtagcatcg 3450181 atttcacgat atccttcgct ttaggggtag accgcttcag caccaatcga agtctggtag 3450241 cgcagcgaga agccccaatc acattctctt ccccgcctac ggcctctaaa atgtcttttg 3450301 ctagtctcgt ataatctctc actttccccg acatttcacc caccccttcg ttttggttac 3450361 gctttcatta taattgtaac ggtataattt atcaattccg aaacaaaata tttacgcact 3450421 aactatcatt gtaagcggtt tatgctataa ttttgacaag tgaaactaaa cgaataaatg 3450481 aggaatgcgt atgttaaaat accagcaaat cgcaacggaa attgaaacat atatagaaga 3450541 acaccagctt cagcagggag acaaactgcc agtcctagaa accctcatgg cccagtttga 3450601 agtcagcaaa agcaccatca caaagtccct cgagctatta gagcaaaaag gcgcgatctt 3450661 tcaggtcaga ggaagcggca ttttcgtcag aaaacataaa cgaaaaggct atatcagcct 3450721 tctgtcgaat cagggattta aaaaagatct cgaggatttc aacgtcacct caaaagtcat 3450781 cgaactggac gtgagaaagc caacaccgga agcggcggaa aacctgaaca tcggaatgga 3450841 cgaggacatc tactatgtca aaagggtccg ctacatcaac ggccagaccc tttgctacga 3450901 agaatcctat tacaccaaat ccatcgtgac gtatttaaac aacgaaatcg tctcccactc 3450961 catcttccat tacatccggg aaggactggg gttgaagatt ggtttttctg atttgtttct 3451021 gcacgtgggc cagcttaatg aggaagaagc ggaatatttg ggattagagg ctggactgcc 3451081 gaagctgtat atagaaagta tttttcacct gacaaatggg cagccgtttg attactcgaa 3451141 gatttcgtat aattatgagc agtcgcagtt tgtggtacag gctaatagtt ttttattata 3451201 gggctcttca ctacggtagg tggtcgacat gtacaaaatt atcattcctg ccatactagc 3451261 catctttgcg ctctggatac tcttacagat ttcactagag atgagcatcg ttaagaatcc 3451321 aatgaactac tttatcgtat tcattatctt tttcctcttt gtaaagatgg tgaaagaaaa 3451381 acaataatag tttgggcgat gcaaacagaa aaacatcctt cccttaacaa actcagccag 3451441 tcacatgcat taatcttgat gttaatgata tataggtgca cataaaaagc tacttcattg 3451501 tgaagtagct ccctttatta aaggcccatt ttgatccatc tagttttaga aaagcgaagg 3451561 acaatcgcat ttatgataat aattgaaact aaatacaaaa taataaataa aacatcatta 3451621 ctcccaagtg tcatgttatc agattgcagc actctttcta ttcgggggta catagtgtta 3451681 cctgcctcaa aaggagcaat gaaaccaaac gttttattgc ttatagctac taagataaca 3451741 gaagtcatcc aataaacgat actgacacct atactaatta atatattagg acataacacg 3451801 cttatagttc cgataattag aatatactgc agtataactg cagaaaataa aaaaagtaat 3451861 aatgcaaaat gcgaaaaatc atggtacatc aacgatatga ttagcaggcc tagcgttata 3451921 aatgcaaaac attctaaaaa taaaacagct atctttttat aaaagaaagt atagatgttc 3451981 tctccaatta acttgtaaaa gagaatattt ttgtttgaat actctctatt aataaagaaa 3452041 gctataacaa atgaaaataa catcaaacca aactgggtcg caacagtata ggagctaaag 3452101 aaaaacattt caggtgtaac attactgact ttatcgattc caacaagtaa aaaataaccc 3452161 agcaaaaata aaaatacaaa cattgctcct aaaataatga taactttgtt gctaatactc 3452221 tttttaaact ctaatttcat ctcaagcccc cactgtttta ttactcattt atatacactt 3452281 caattaattt atccactgaa tgatattgtt gaatttcttg gtgattaaat atataataat 3452341 ccccttctat cgcctttaaa tcagacaaat catgtgtaat gttgatgata atcttctcgg 3452401 ggttctcctg aatatacttg tttaagaagc catgaatctc tataaccgtt tttttgtcta 3452461 atgaattcgt tatttcatct aaaacaataa tatttttatc ctctaataag aaactgagca 3452521 attttaattt ttgcttttgt ccatcactca aatttttgat cagaactttt ccatcaatat 3452581 tatccagatt aagtaaatat gcgattttat ctatcatttt tgcatcaaat tttttactca 3452641 aaaagtgtaa taaaaagtcc ttagaaacat cattaggtat attcgacgag ctggatatta 3452701 aagaaacatt ttgacgaata tctctgccga ttcttttgct attattcaac aaaaagtctt 3452761 tagcaagctg tgatttaccg actccatttt ttccgacaac gtgattaatt ttcccgctcg 3452821 aaaaatgcaa gtcggtgtcc tgaagtaacg ttttgccttt cacttttaaa gtgtaattcg 3452881 ctatattcat atacatactc ctaggaaata tttgcataat aataaaatgt tctgccttgt 3452941 gatttgttac taatgtctaa gcttttgagg tacctctttc gtttccgatc cggaagcgaa 3453001 agaaatgttt ttagatggct aatttggaga tcttttactc tagtttacaa tatataatat 3453061 ccaatgtaca actgaattca ctgcaaggcc aatccctata atttgaatcg taagaactaa 3453121 ccaatgattt gtcttaaaac ggctatattc atctaagctc agaaaagcta aaagaatttt 3453181 gtaaccatca gaattcaata ttgggattaa gttccacaat aaagtagacg agaaaagcat 3453241 aaatgccata gttaatgctt cactggaaaa tgtaaattga tttattaatt ctaatgtatt 3453301 tattaaaaga taattgataa acaagccaaa taaatgaacg attatctttt catttcttga 3453361 tagcatgtag gtttcattca attggacata aaaagcagga aatacataaa aattcagttt 3453421 gaatcccact ttatcaaagt ttttcccgaa aaattttaag gaataaatat gtcccagttc 3453481 atgaagcact atattcatta taaaataaat aactataatt atccacattt tccagccgta 3453541 aaatactgag gacaatccat tttgcaattt tattaaatga atataattta atatgaacat 3453601 gagagccgta aaggataaga acagataaaa aaactttggt gatactttct ctttatacat 3453661 tttaaaacgt aataattgtt tatctgacag agaatttaaa ctatttttat agtattctcc 3453721 gctttttttg tcttttataa atacgttgtt ttgcacaagc acttcatatt tttcatcttc 3453781 atactttaaa attttcatta tagtattttt ccatataagg atagaagtag tttatttttt 3453841 ctgcagagtt gaataaggaa ccacaaactc cacaaataga ggaaaattca taaggaatgt 3453901 caaattcctc tattttgtta ttttctttta aaatattcaa aaaccatttg aatccttctt 3453961 ttctaagaat aaataatagc aaattggaat ttaacttttc cacggttctt tcgaaacttt 3454021 ggttatattc ttcccttagg gttattttcg tttcaaaaat agcaggggaa caacatggat 3454081 aaatttctcc atcatgatga tatacaatgt catatccggg acaatgtaag gaatcttcat 3454141 cttcaagact gtaaaattta tgtatgtttt cttgcttaat tctagtttta gcagcgccaa 3454201 ctgatatcat tggaaatttt gttatcttta cacctaagat tgaatccccc aattcctcta 3454261 aaatgtggtt ggacattttg tctttggtaa ctgccatatt aagagaaata tcgatatcag 3454321 ggtatttcct gctatgttct aatatgtttt taatactgga agacttgaca aatggagcat 3454381 ggtactcatc ataacttata gtcagtgcta tcacatttaa agaattcata tcatgaaagt 3454441 actcctggac ctttttcttg ctcaaacccc aaaatccatt agagatcaac gttatttgtt 3454501 tttcatatgg tttaatgatt tccattagtt cttttaaaaa tttataatct aaaaaaactt 3454561 ccccacctgt aaaagaaatc acttgaatgg ttttgttttt tgcaaattca gttactaact 3454621 ctcttatgta ttctttttcc atcctggttg ttgaagttgg tgaactagaa aaacaacaat 3454681 ggtcacagga tgcattacac cttgaatcta aattgattga tactgtttta ttatacatga 3454741 aatatccccc aacaaatggt aaaggagagt tagactctcc tttgtacccc tctaattaat 3454801 gaccacttcc aagaatccag cgattttctt ttgattttac aaaataccaa agatcattca 3454861 cttttgctaa cttttgtgat tcatctaata gacccttaaa ttctaagttt ttcacagtct 3454921 cattgttagt gatttccttt ttcatattat ccctcctcct tttctaatat aaaccaatta 3454981 ttctatatca ttcaatacat gtcaatatat tgtacctaaa aaatctgaaa aatgtcacta 3455041 ttcttggtat ataaagccta tagtcctcta gcccctctaa gctataccga atgaaaggcc 3455101 atagtttgat ttaaagcttc gtaatgaaaa gtaaaacatc aatattgact acactagtta 3455161 agggatatac agattttaag tggaagaaat gaggcaaaca atcttaccct aaaccaacct 3455221 gtactgaaaa gctgttttaa gctcttgctt accccatttg gcacctcttt ctctcgtttt 3455281 aattgtctct aaaagcagtt atgcggtact atcatataaa ggtccaatgt ttaaaaataa 3455341 tgtcatactt ttaaattcac cttatcatgc acatgctcat aaagaggggt ttattctaaa 3455401 aaggggatgg acggttttgg aaagcaagta cctagatcta ctcgcacaaa aatacgattg 3455461 tgaagaaaaa gtggtaacag aaatcatcaa tttgaaagcg atattgaacc tgccaaaagg 3455521 caccgagcat tttgtcagtg atctgcacgg agagtatcag gcattccagc acgtgttgcg 3455581 caatggttca ggacgagtca aagagaagat acgcgacatc ttcagcggtg tcatttacga 3455641 tagagaaatt gatgaattag cagcattggt ctattatccg gaagacaaac tgaaattaat 3455701 caaacatgac tttgatgcga aagaagcgtt aaacgagtgg tataaagaaa cgattcatcg 3455761 aatgattaag ctcgtttcat attgctcctc taagtatacc cgctccaaat tacgcaaagc 3455821 actgcctgcc caatttgctt atattacgga ggagctgtta tacaaaacag aacaagctgg 3455881 caacaaggag caatattact ccgaaatcat tgatcagatc attgaacttg gccaagccga 3455941 taagctgatc accggccttg cttacagcgt tcagcgattg gtggtcgacc atctgcatgt 3456001 ggtcggcgat atttatgacc gcggcccgca gccggataga attatggaag aactgatcaa 3456061 ctatcattct gtcgatattc agtggggaaa tcacgatgtc ctttggatcg gcgcctattc 3456121 cggttccaaa gtgtgcctgg ccaatattat ccgcatctgt gcccgctacg acaacctgga 3456181 tattattgag gacgtgtacg gcatcaacct gagaccgctg ctgaacctgg ccgaaaaata 3456241 ttatgatgat aatccagcgt tccgtccaaa agcagacgaa aacaggccag aggatgagat 3456301 taagcaaatc acaaaaatcc atcaagcgat tgccatgatc caattcaagc ttgagagccc 3456361 gattatcaag agacggccga actttaatat ggaagagcgg ctgttattag agaaaataga 3456421 ctatgacaaa aatgaaatca cgctgaacgg aaaaacatat caactggaaa acacctgctt 3456481 tgcgacgatt aatccggagc agccagatca gctattagaa gaagaagcag aagtcataga 3456541 caagctgcta ttctctgtcc agcattccga aaagctgggc cgccatatga attttatgat 3456601 gaaaaaaggc agcctttatt taaaatataa cggcaacctg ttgattcacg gctgtattcc 3456661 agttgatgaa aacggcaata tggaaacgat gatgattgag gataaaccgt atgcgggccg 3456721 tgagctgctc gatgtatttg aacgattctt gcgggaagcc tttgcccacc cggaagaaac 3456781 cgatgacctg gcgacagata tggcttggta tttatggaca ggcgaatact cctccctctt 3456841 cggaaaacgc gccatgacga catttgagcg ctatttcatc aaagagaagg aaacgcataa 3456901 agagaagaaa aacccgtatt attatttacg agaagacgag gcaacctgcc gaaacatcct 3456961 ggcagaattc ggcctcaatc cagatcacgg ccatatcatc aacggccata cacctgtaaa 3457021 agaaatcgaa ggagaagacc caatcaaagc aaacggaaaa atgatcgtca tcgacggcgg 3457081 cttctccaaa gcctaccaat ccacaacagg catcgccggc tacacgctgc tatacaactc 3457141 ctacggcatg cagctcgtcg cccataaaca cttcaattcc aaggcagaag tcctaagcac 3457201 cggaaccgac gtcttaacgg tcaaacgatt agtggacaaa gagcttgagc ggaagaaagt 3457261 gaaggaaacg aatgtgggtg aggaattgtt gcaggaagtt gcgattttag agagtttgcg 3457321 ggagtatcgg tatatgaagt gaggggtgtg gggttcaggg atggtgatat gctgctcccc 3457381 taaaagtaga tagatgaatt ttagaaaatc tgtttgcctt ggggagtttt ttcatggctg 3457441 gacaattata ctacaaggaa gaaatactaa tacttataga atgtaattgg gtaatgattc 3457501 ggagaaagag gttgcgaaat aatatggtat tacactgaaa caattatcaa tggagaacat 3457561 gcacgatata gccgttctat attctccctc tattatggca ctcattagta gacataaccg 3457621 taaaaaaatg cactcaaaaa aagtccattc tatataactc tcgctagggt ggaccttttt 3457681 caacattcaa agtactagat tttttctagt gaaagaataa gaaaagacat aagttctatt 3457741 ttatcactct gttataggtt aagttattac ggtgtttcat tatatactga atttaaacac 3457801 ccttgacatt atgggaattt ttaaaacagg ttaaaaggaa gttctataag aactccctag 3457861 tttaatatta tttggtcaaa atctaaaacc aaaaaatcta tttttatctt cattgtttct 3457921 atctaatttt gcaacaatca tacctttcga ctctaattct tgaaggtcat ctaataataa 3457981 ttcattttta tttattgtta caaaatattg tccgatccta ttctctaaca gacttgaatt 3458041 gatatgtttt aataatgtac cttttacatg aggatcagga ttagaataag atccgtcatg 3458101 aattaaaata ttcaaactac acttatttat acacctgtat aaaaaccaag taagatcaaa 3458161 tatatttatc ttcatatgga gtctaccatg tgaacgttca tccggtatag aacaagaaat 3458221 tttgatcctt cctgtagttg attgttttgc gttacttatt ctattatcat attcaaaatc 3458281 taaaaatcca tgttggttgt atgtaacatc cattagatta ttaaaaagct tctttaactc 3458341 actaactata gcgctataag attgaaactc atcataatac attgaattaa ctcttaatat 3458401 ttcatgttga agttcattaa tcttatcaaa aatatggttt tttttatcgt agtcactaat 3458461 tctcaatctt acttccgcta actctatttc tttccttctt tgttcttcca tcacaatgga 3458521 aatatcctca atgaaattgt tactctttaa aattctggca cttgattcca gttgttctgt 3458581 taatccttgc tttttgatat taagtttttt taaatcggct tgtattttaa caattttatc 3458641 tttaaaataa ctccctctac tttctaccat gaaattatag aactcttgga ctttattata 3458701 attctgtttt acttcctctg gaaaaaaacc tacaatatct tcatagaatt tttctatatt 3458761 ttctaattct ttaatcttag ttactttttt atttaaatca tctatatttc tttgatattg 3458821 tttacaaata tgttcatttt caaatatttc attttgtatt ttattaagtt cacttttaat 3458881 ttctgagtac ctatttgtat cattattata tttattggca gtcttagttt gatagataac 3458941 tctattgtaa tcctctatct catttattaa ttcatcttcc ttaactttta aatcgccaat 3459001 gttaatattc attgattcaa tcaattttat ttcactattt aatttttcaa tcttatcccg 3459061 aaaaaccttt atgttttttt ctgtatgagt tggtaaagta aaaagatagt taagtaattt 3459121 atattgtttt aaccctcccc tattcggtaa aactatatca ttaaaccctg tcttttcgtc 3459181 tcttataata tactccctta acgccgcaaa agttatatcc tctttctcac cctttaaaat 3459241 ttccttttca ataaattttt tatatacact tatactaact tttttccatt cctccaaatt 3459301 aaaagttaaa gaagtatcat gtaatgtata accatgttta ggagaattaa aagatctagc 3459361 aaggaatact tgatttccat caatttccac attcaaaaca ataaaaacgt ttttattgag 3459421 aagaatttca tttgtcgtat aaaaatttga tatagtcttc cctagtaaaa aggagatgca 3459481 ttcaatcatc gttgacttac ctacaccatt agtctcttca tgatcttctc tcttttcacc 3459541 aagtattata tttactccta cagcattaaa tttatactct ttcaaaattt cttgggaatt 3459601 gcaaacaaaa agatttttta taatcataac aatcactaac tctccgttct gctaatcata 3459661 ttttgattaa aagaaacttt acctaatgaa tataaaaaag ttaacgataa atacagtatc 3459721 cgttcaatat tcaaatttat tataatacct tgactcttag cataatcaag aaaaagttga 3459781 tcaatatgtt tttccttctc taacagttca taaagtatct ttgatgagta taaaatattt 3459841 tcttccacag cattatattt agttaataaa aaatgattca tttctggcct ctccgccttt 3459901 tcctttttta aaggagaatt attcactaga ggaataagat catttccaat ttgaatgttt 3459961 ttaaactcat tttctaataa aacataagag tatttgagaa tattttcagc tgtttcaatt 3460021 ttaagatcaa tcattcttaa cacttctttt gttatcatta aaaatctcac attcataaat 3460081 gcaccaacat gttaaaatct taatgtattt tttcgttaaa gcctttgaat atggtaaaac 3460141 tgaatgacat tctagataaa tctcattaac aatttttaca aatatctcat ctccattatt 3460201 atattgatta tgaaactcta gatatttgtc tactatcgtc tcagcaatca attccttttt 3460261 atcagcactt acatacgaag tggaatccat tatatggttt atcacaccaa aatactcaga 3460321 ataactatcg aatttccgtt taaaagtttc cccacttttc atatcataaa attttttatc 3460381 taaaccaatt tgattatcaa aattactagt aaatgtttta taactttctc tatactcatg 3460441 aaaatctata ataaagctct taaactcatc ttcatcaatt ttatcatcgt tatcttctat 3460501 ttctttttca ataaggctct ctaatctatt aatcttataa tttaacttcc cttcctgtag 3460561 tctccttcct ccttggttgt tttttgacca gtatttatat tcggtattcc aaatgtagta 3460621 tgttacttct gtctcgccat tatctaaatt cacatccacc gaaataaatt ctggagtagc 3460681 atactcatcc tttataatgg ctccacttac taattctaag aatggatttt catttgtatt 3460741 tgcagtaata ttaaatgaag aatcatgtac atgtcctgcc aaatatagat caataaagta 3460801 atcatcaaaa tgtgccttta ttgattctct ttcggaagat tcaatacaac ctaacgtatg 3460861 gtgcccaata gctatattta ataccttgcc cttatttttc tctttgttca tcttccttat 3460921 tgctttatat aatttcatct gtgcagttaa taacgttcct tcttcacctt ttttatctga 3460981 taacagacat gtatttattg ataaaacatt atacttctcc gattgataca aaaaatgcaa 3461041 atcttcttcc ggatatttaa cacccataaa atcttcataa aaatcgaaaa atttcctttg 3461101 accttccact aatatatttg tagctttttg atctagttta tccaacattt ctgaggggtt 3461161 aggagatttc ataatactat caatcaaaag tgtcctcgtc atgtctctag atatatcgtg 3461221 atttcctggc actaagtgta cgttattctt acttaatccc atacttttaa taattccatt 3461281 aagatattct ttaacatctt cgttatacac atcacctttg tgtgctatat ctccagttaa 3461341 taataaaaaa tcaaaatctg actctcttct taaaacttct ataaaatcta ataatttatc 3461401 tctcattaca atagtgtcat aattttgaaa ctgaaaatgc aaatcagaaa tttgtaaaaa 3461461 acgtaccttc aatacaaaca tcctctcata agtatattta tcccctatat atttctagaa 3461521 aactttttat tctatatcat ctttactctt taatatatta agactctttc cacaccatca 3461581 aataaattat aacctaaaca taactcttta ctcattttag tattgtattt aagtcaaaca 3461641 ttgcattggt tgctgaaata ttatattcat tgaattattc cattaaatag cttttagttg 3461701 aactttagtc tttctgtaat ggtggagatg ctcttactta tgataaggct ccccacgatt 3461761 aatccgaaaa gcccgataaa tctgctccac taaaataagc cgcatcaact gatgaggaaa 3461821 tgtcatcttc gagaacgata gcttctcgtc cgctcgcttc atcaccgtgt cactcaatcc 3461881 gagtgatccg ccgatgacga aggtgacttt gctttttcca taagtagcca gcttatctat 3461941 tgtatcggct agttcttcgg atgttttcat ttttccttcg atggcgaggg cgatgacgtg 3462001 ggcgtcgggg ctgattttgg ataggatgcg gtcgccttct ttgtctttta tgattttcat 3462061 gtcctggtcg cttaggtttt ccggcgcttt ttcgtccggg agttcgatga tgtcgatttt 3462121 tgcgtaggcc gaaagtcgtt tggtgtattc ttcaatgcct tgcttgaggt atttttcttt 3462181 tagttttccg attgtcacaa tattgatatt cacaggtcat ccccacttta aaaacaagtt 3462241 attcatatat gttgtccaca attgtggata tcttttctgt attttgtgta agatcattcg 3462301 ttccccacta tatatactgc ggggtctcca cataattcac aggctgtgga taaactgtta 3462361 gtatgttcga tttttctgat ttcgggcggc agctcgtggt cgtctatgta catatccagc 3462421 accgtttcga tgtgttcttc acaagaataa tacgcttgtt tcatgttcaa atcctccgat 3462481 gttttcttcc atttttacaa atgttctctt ctcaatataa cctatttatt cacatgttag 3462541 tagtgcttcg ggctgagttt tatccacaat tcgacaaaca agctgttgat gactctattt 3462601 cgctcgtgtg ttagtttgga tgtaaccgat gtgtggggag gtctgcattt gcgctttaga 3462661 tgggtttggc tttttgtgat tatgttgctg cttgctgagt gtcagccatc ttattgggtg 3462721 ttggagaagg atcgaatcgg tgaaggcagt ccagacttag aaatatacgc taattatctc 3462781 caaatgcatg atgacgtgaa aggatatcaa gtcttcacca tatcagaagg caaaaaaatg 3462841 gtcgtcgtgt ctctcggaag cagcgagaaa gataagaagc ttgaagtgtc ggacgtcaaa 3462901 ttctcatcta aagaaacgat tgtaactgtg gagcgaaaac ctgctcctac ggcaaatgag 3462961 aaaaaccctt ttattttgat tggactggac aaaattgaag gggatttaat tgttcaagac 3463021 gaaacaggag atcgctttga agaaacggat taccagcaat aaagccggcg ttctgagaac 3463081 gtccggcttt ttcttttact tcaatgtccc atgcgggtcg atgacgaatt ttttggctgc 3463141 gcctttgtcg aagtcgctgt agccttttgg cgcgtcgtcc agagaaataa cggtggcatt 3463201 gacggctttt gcgatctgcg ctctgccgct caggatcgct ttcatcaaat tgcggttgta 3463261 tgtcatggcg ggcgtttgtc cggtgacgaa ggtgtgggct ttggcccagc cgagtccgaa 3463321 gcggattttt aatgagcctg ttttggcgtc cgcatccttt gcaccgggat cttcggtcac 3463381 gtataagcct ggaatgccaa ggctgcctcc gacctgggtg acgtccatga ttgagttcag 3463441 cacggcggct ggcgcttctc cttgattgcc gtgcccagat gcttcaaagc cgacacagtc 3463501 cactgcagca tcaacggttg gttcacctag tatttgttca atttgctcgc cgaggcggtc 3463561 gtgtttttgc acgttgaccg tttcacagcc gaagcttctg gcctgtgcca gcctgtcttc 3463621 gttcagatcg ccgacaatca cggtagaggc gcctaggagc tgagcggagt gtgcagctgc 3463681 caagccgaca ggacccgctc cagcgatata aacggttgaa cctgtttgca cgcccgctgt 3463741 ataagctcca tggaagccgg tcggaaaaat gtcggacagc atggtcaaat cgagaatctt 3463801 ttctagcgcc tgttctttat cagggaatac caaaagctga aaatcagcgt atggcaccat 3463861 gacatattca gactggccgc cgacccagcc gcccatatcg acgtagccgt aagccgatcc 3463921 cggccggtcc ggattgacat tcaggcacac atgcgttttc tgcgttttgc acatcacaca 3463981 gcgtccgcag gcaatattga aaggaacgga tacgatatct ccttttttga taaattcaac 3464041 atcacgcccc gtttcaatga cttctcccgt aatttcatgc ccgagcacca agccttctgg 3464101 cgccgttgtg cggcctctga ccatatgctg gtcgcttccg caaatgttgg ttgtaatgac 3464161 tttgagaata accccatgct cacattttcg attcacattc gccttcggga cgccgggccc 3464221 gtccctcaag attaactccg gataaccgat atcctccacc gctacagtcc ctttgccttt 3464281 gtacacaacc gctttgtttc ctgtcaacgc cattcctccc attcatgtgt ttggactctc 3464341 cgtccttgaa catgacttcg gttcggcatg actctttccc tttttcacga ctgttttttc 3464401 tgtattctta caacaacaaa tatgccaaga aagcatccaa taatggttcc gccgatgtct 3464461 aagaagtcga ctttacatcc atttaacaag aacacagtaa tggccgaaac caggcagatc 3464521 ataactgcca gaagaataac ccgatttgtc tgcatgtaat tcctcctttg gattcgtttc 3464581 taaaccatac ccaaaatcct ctgcaaactt cggttcaaca aaaaaagaga cttcacacca 3464641 gtctcttcat aaacagagat cactcaaaaa atttcctgag aaataatgtg gcaacactcg 3464701 ttactaacgc aattgccgta tacataacaa cccaaaatat gaatgagcta ttccccgaag 3464761 ctaacgtaac taacaatatc aagctcgtga taagaacgat gagcggtgcc acccaaaatc 3464821 ttttaaataa aaaatgaccc gctataccaa atacacctgc gacgatcgga aaaccaaaaa 3464881 cgataaataa aacggcgatg gctcccatac taccctcctt gccttaaaac ctcttcatca 3464941 cctcaacatc atacagcttc aaatgactct tcggcgtcac gacatccttt accttcccaa 3465001 tctctttttc tttcattttc tttccggttt tcaggctgta ctgttcaatg taggcaggct 3465061 tgtgatacgt gtatgtgaag aaatagaggc tgctgccttt ttgggtgatt tctttgaatt 3465121 cggctttcat tttgtccggg gaaagggtga agacgatgct tgtttttcct gtcttggcat 3465181 cgattttgtg tacctttccg aagccgtcaa tgaaatacag gttcccgtca taagggaaaa 3465241 agctgttttt aaagctgaag ggcatggagc tgtatatcgt ttgttcgtcg tttttgtatt 3465301 cggcgatatc gtgcagctct acttcgccgc tttttttgtt gatcttgacc atttgataga 3465361 gatcgtgggc tttttggccg cgaaccataa catacacagc ttggtcgtcc acggcaagtt 3465421 gggattcgac tgaggctcct tcccggtact gccattccgt tatgctgaga taggtaagct 3465481 tcttctgatc tgcttgaatc tgaaggagct gatagccttt tccgtcatct gtcgggacga 3465541 gtgcgtaaat ggcgccatca tggaaaccgg aggctcggat gtagtagggg atgacgtctt 3465601 ttttccactc tccgtccatt tggcggtaca gctctgagcg gtatccgtct ccctttttgt 3465661 cgtagccgga gttgtataag gtgtaaaagc cgtccgtgtt ttgcagaaag cccgcgctgt 3465721 cgcctgtgtg ctgataggtt cttttatggg agcgcaggcc gtttttgatc gtataaatcg 3465781 tgtttttgtc ctccagcatc acgctgtcac cgtgaacctt tgctgagccc agctcaaggc 3465841 ccttcatctg aaaggaagac agcgtcccgt catggctgat aaacagggcg tagcttttcc 3465901 cgccgccaaa tgcatcttga tccgcagagg atgagaaata cagcaggact tctttgtcat 3465961 ccaggaaatc gggatttctg agatcctgct gactcacggt tttatggctt ttgagaggag 3466021 aaatgaagac aaatagtgcg attcctgcga gaatcagcat ggcgatggta atcatccact 3466081 ttttcatagc cttctcctta gtaaatggtc ataatggttg tcgtataaga agaactagtg 3466141 atgtcgcgcg gatacacgcc taagcctccg ttgctgtcta tatcaatccc tgctttcagc 3466201 aaaaaggcag accataggag ctttgaacag tttttggcgc cgtcatggcc ggtatttctg 3466261 ttattgacga agttaaatga gtatgggtcg ccgacttttg ataccgccca gtcggcagca 3466321 gctgtttttt gagatgagga tacgctgacg gtttgcacaa tggagttgtc ttccacgtct 3466381 ctggcattat acgcgatctg cctgacgccg tcgctcggga cagattcaac aattttgtca 3466441 gcggcggagt acatgccgac atggccgtga ttgtagtagg ctgtgtagga gttcgtgtaa 3466501 tagatattgc ctttcgcgct tgtcgggagt tttttcgtgc cggacgagcc gcccatgata 3466561 gacatgccgc tttccttggc gagccggtcc ccctctgctt tatcagccgt gatctcctta 3466621 tagaactgtt ttaggataac gtcctgcttt acgtgctgct gtttggcaat ctggctggca 3466681 gatttcatga tttcttccgg tgtcgtgcct ggctgcagtg cggcgatttc ttcagcataa 3466741 tttgtggtct ttacggcttt ggcgggagta acaaacaggc cgccgcacat tgtgagcgct 3466801 accaaaaaca tcgacactcg tttcttcaac ttcattacat ctcctctttt cttgtgagtg 3466861 taggaaaggt aatttcctca cccacattat attaggaaaa taaggaaagt aactaggtta 3466921 tttacagaat ttttagaaat cgtttacaga aaaaggcctt tatcaggccc ttttcgttaa 3466981 agcttcttgc tcatcactac gtctgtttct tgaaatccgg tttgctcata tagctttcga 3467041 gccgtctgat tatgggcaaa gacatgaagg gacagcttgc ggattcccat actgcgtgcc 3467101 gcttgatcta atgccgccaa tgcttgcttt gcgtagccct ttccccgata cggttcatat 3467161 aacccgaaat cataaataaa cgcttcctgc tgcggatgct ccggttcagc atgtatccag 3467221 agccagccaa cgatatcctt ttcattcagc ttgaggctcc acaaatggtg atggggtgtt 3467281 tcgagccctc tcggaagcag atcagtaaac acctgcttag acaaaagctg ggcatcttca 3467341 ggcagccatg ttcccgcttt taccttttct tccgcgtaat gctttgttgt gtacgtgaga 3467401 taagaccgaa attcttctgt ctgcataggg gttagcataa ttgtcatatc atctctcctt 3467461 catatattga ctagaggatt ttacataaaa tagaaagagg tgttactatc agaataagca 3467521 actgagattg ataagtcact agagaaagga gtttcacatg aataagatcg cacccgcaga 3467581 aatcgctagc atgctcaacg attggtacct tgccatcaag aaacatgaag ttgaagaatc 3467641 ctcccgttta tttgaagaag tgaagccttt attggatgac atggaagagg atcaggaggt 3467701 gcttgcctac ttctccttat tggaactgcg ccacaaggtt ttgcttcacg aggcgagagg 3467761 acagggcttt cagcatgagg agccttctca tatgaatgct acgtctgaca tgctgaaata 3467821 ttactttttt ctgtttgaag gcatgtatga ggcctataaa aataattatg acattgccat 3467881 tgggctgtat aaagatgcag agcagtatct cgacaacatt cccgatccga ttgaaaaagc 3467941 cgaatttcac ctgaaggtcg gtaagctcta ttataagctg ggacaaaata ttgtgtccct 3468001 caatcataca cggcaagcag tcaaaacatt cagagaagag acagattata aaaagaagct 3468061 ggcttcagcc ctgattacca tgtcaggcaa ttttacagag atgagccagt ttgaagaagc 3468121 tgaggcttat ttggacgaag caattcggat cacgagtgaa ttagaggatc atttttttga 3468181 agcccagctt ttgcataact tcggccttct acatgcgcaa agcggcaaat cagaagaagc 3468241 ggtttcgaaa ttagaggagg ctctacagaa cgatgagtat gcccgctccg cctattatta 3468301 tcattctgcc tacttgctga tacgagagct gtttaagatc aaaaagaaag aacaggcctt 3468361 atcttattac caagacgtga aggaaaaatt gactgctgag ccgaatagaa tatgtgaggc 3468421 aaaaatagac attttatatg ccatttatgc agaagggggt catgcggaaa cgtttcactt 3468481 atgcaaacaa catatggatg acttgttgtc cgagaaagag tatgacagtg taagagaact 3468541 ttccattttg gctggcgaac ggtataggga acttgagctt tacaaagaag ctgcccactt 3468601 tttttatgaa gcattacaga ttgaagaact gattaaacga acggaggtta tataaatgaa 3468661 aagatttctg attggcgcag gcgtcgcagc ggtgatttta tcaggttggt ttattgcgga 3468721 ccatcaaacc cactcacagg aaatgaaagt cgctgagaaa atgattggat aaatgaaaaa 3468781 cccccgcggg atgcgggggt tcaatttaac gaaagaatcc taaaacggtt tgtagtttta 3468841 ggattctttc atcttttcag cgtgattgaa aacccttgaa gtctaggaag aacgagcatt 3468901 ggagcgcagc gaatgtttgg aattcgtgag caccgaagcg caggcctgac aacgaatgcg 3468961 agggtttgtc gacacgctga aacccccgcg ggtgcggggg ttttcttatt acagcagctt 3469021 cttccctaac agggattcta cgagctctac tgctgttttg cccgttttgt ttttgtgatc 3469081 aaggatcggg ttaacctcaa cgaattcggc tgaggtaatg atgcctgcgt catacagcat 3469141 ttccatagcc aaatggctct cccggtagct gatgccgccg acgacagggg ttccgacacc 3469201 cggtgcgtcg ttcggatcaa gtccgtccag atcaaggctc agatggacgc catcacatgc 3469261 tgataaataa tcaagggttt cttcaatgac ctttgtcatg ccaagacgat cgatttcgtg 3469321 cattgtgtac accttcatgc cgctttcctt aatgtacttg cgctcccctt catcaagtga 3469381 ccgggcgcca atgatgacga cgttttccgg tttgatttta ggcgcgtagc cttcaaggtt 3469441 aaccagtgac tcgtggccaa tgcctaggct gaccgcgagc ggcatgccgt gaatattgcc 3469501 cgatggtgaa gtttcaagtg tattcaaatc gccgtgcgcg tcataccaga tgacgccgag 3469561 attatcgtaa tgcttcgctg tgcctgcaag cgtgccgatc gcaatactgt ggtcaccgcc 3469621 caggacaagc gggaattttt tctcttcaat gactttgttg accttttgcg cgagtttttc 3469681 atttcccgcc aaaacggaat tcaggttttt cagttcctcg tcatttttga ttttttcgcg 3469741 attgatcgga atgtcaccga gatcttcaac cgtatacccc atgtctgaca gcctctcgat 3469801 cagatgagcg taccggatgg cactcgggcc catatccact ccgcgtcgtg cttgtcctaa 3469861 atccattggc attccaataa ccgaaatcgt tttatccatc tgtgattcca cctcaacatt 3469921 taagataatg tcctatgcgg gttataacaa agatgacttg cggacaacgt ttttaaagct 3469981 ctagctgacg atttgcctgc tggcgttttt taatgacgac atgataaatg atgtagcaaa 3470041 tgatcataaa cggtacgccg caatacagcg cgatacgctg ctccggatca aatgcaagac 3470101 tgatgagcac gaccgtattt aacgttaggc cgatcagcgg aagcaccggg tacagcggtg 3470161 ttttaaattt caaatcttct atcttcccgc cctcacggat atatttgcgt ctgaacatga 3470221 tttgggaaag cgagatcgta atccagccga cctgcgcgct catgcccgcc aaagataaca 3470281 gtaccatata tacggtttca gcctgcgcaa actttgtcag aagtgatagg caggccacag 3470341 ccatcgttac gattaacgag tacatcggta caccgcgctg atttgttttg ccaagcgctt 3470401 tgaaggcttg tccttcattc gccatcgcgt acagaatacg tgttgatgcg tataaacctg 3470461 agttcgcaac agataacagt gcgattaaaa taacaaagtt catgatatca gctgcatatg 3470521 ggattccgat ttgctcaaat acggcaacaa atggactttc cacgacaccc gcctgtttcc 3470581 acggaatcat gccggcaatg acaatgattg aaagcacaaa gaacacaagc gttctccata 3470641 ctgtctgttt gatggaccgc ggaatcgttt tttcagggtc ttcactttct ccggctgcaa 3470701 ccccgatcag ctcagtcccc tgaaacgcaa agttcacagt aatcatcgta atcagcattg 3470761 cctttatgcc gttcggaaat aacccgtctt cataaaaatg tgtcaaaaac ggcgcctgct 3470821 ctccgccctt cagatcaatc aggccaaaca tggcagctcc gccgagaata ataaataaaa 3470881 ggataatcaa aattttaatg cctgagaacc agaattcaga ttccgcaaag gcttttgtgg 3470941 tgatcgcatt taaaataaac atcagtgccg caaagaccag acaccagatc cacacgtcta 3471001 tatgcggaaa ccagcgttgc atcagctgcc ccgctgataa aaattcaatg gcgcatgtaa 3471061 ccgcccagcc gagccagtac agccagccga acgcaaaccc gaaggccggg ctgataaatt 3471121 tcgtggcata ggtctggaag gaccccgaca caggaaaggc gactgccagc tctcctaagc 3471181 agagcatggt caaaaacatg ataaagccgc ccactaaata ggacagaacc gcgccgagcg 3471241 gtcccgcttg gttaatggta aacccggttc caaggaagaa accggttccg atcactccgc 3471301 ccaatgaaat catgaacaaa tggcgtgatt tcattgtccg ctggagctga tttccgttat 3471361 cttggtttgt attcacattc tgcacccctt cagcaacttg tattggatct aagctggaac 3471421 atctgcatgg tgctatccca gtttgctgtc caaagagtct ctatctattt aatataaaat 3471481 tcacttcttc tcataaagat acattatact aaaatactgt agctgagcaa atagggagtg 3471541 ctgatttttc tgttgtaaat ttatacaaac gaagtgaata tcccgccatg gtgcggattt 3471601 atgcgtttcg cagcacgtgc ttaattttct ctatcgccca atccaagtcc tctttggaaa 3471661 tgattaatgg cggtgcaaaa cgaatgactg tatcatgcgt ttccttgcat aaaagtccct 3471721 cttccttcaa acgctcacaa tacggacgtg ccgcttcagt caattccaca ccgataaaca 3471781 gccctctgcc gcggacttct ttaatgacag ggctgtcaat actctcaagc tcgcttttaa 3471841 agtattcacc aagttcaaga gaacgatccg ccagcttttc atcctccagc acttctaatg 3471901 aagcgataga cactgcacat gcaagcgggt ttccaccaaa tgttgagccg tgtgagccag 3471961 ggttaaacac gcctaggatc tcgcggtccg ccgcaatgca agagatcggg aacacaccgc 3472021 cgccaagcgc tttgcccaag atatacatat ccggaacaat gccgtcccag tcacaggcaa 3472081 acgtcttgcc tgtacgtccg agacccgtct gaatttcatc cgcaataaac aagacattct 3472141 cttccttaca aatcgccgcc gcttcctgta aaaatccttc aggcggaatc acaatgcccg 3472201 cttcgccttg aatcggttca aacaagaatg ccgctgtatt cggcgtaatg gcctgtcgaa 3472261 gcgcttccac atcgccgtaa ggaatgagtt tgattcctgg aagcatcggg ccgaatcctc 3472321 gtttatattc ctcttcagaa gaaagagata ccgccagcat cgtgcggccg tggaagttcc 3472381 cgacacatgc gataatttcc gcttgattgt cagctacgcc cttcacttca tacgcccagc 3472441 gtctcgccgc tttcaccgcg gattcaaccg cttcggctcc tgtattcatc ggcagaatca 3472501 tctctttgcc tgtcagttta gctgtttttt cgtaaaacgg cccaagctga tcgttatgaa 3472561 acgcgcgtga cgtgagggtg attttatcag cctgatcctt taatgcctga atgattttcg 3472621 ggtgtctgtg cccctggttt accgcagagt aagcactcag catatccata tattcattgc 3472681 cttccgggtc ctttacccaa gcacccagcg cttcagaaat aacaatcggg agcgggtgat 3472741 aattgttggc tccgtaatga gacgtctgat caataatttc tttggattta gataaagctg 3472801 tcatatttga attccccctt gttttctgtt tcaacatgtt atcctgcttt ccctttatat 3472861 aaatgcaagt tctgtgccaa atcaagaatt cgtgtgtttt ctacaatttt cgaggacaag 3472921 gtgcaaaaac attctgatat ttcgagcgaa aatttcagca agtgcaaaat tcttttgcat 3472981 atcctctccg tttttttata aaatagaagc aatattaaga aaataattga gggaggttca 3473041 tacagtggtc aaagacagcg aattcctcac attggttttt cagagtattt tagatgaaat 3473101 cgatgttggc ctgcacgtgg tagacgagca tggaaacaca atcgtttata acaataaaat 3473161 gatgcagatt gaagatatgg agaagcatga cgtcttgaat aaaaacctga tggatgtgtt 3473221 tatgttttca aagcagcagg acagcacact ggtacaggct cttcaggaag gcaagacgat 3473281 taaaaacgtc aaacagagct atttcaataa taaaggccag gaaattacga cgatcaatca 3473341 tacatatccc atcgtccaag acggcaaaat caggggcgcc gttgaaattg ccaaggatgt 3473401 gacaaagctg gaacggctga tcagggagaa tatgaacaaa aaaggcagca caacctatac 3473461 gtttgacagt attctcggca ccagtccggc cattcaagac gtcatcgaaa acgccaagcg 3473521 ggcaacccgt acgtcatcat ctgtccttct agcaggcgaa accggcacgg gaaaagaact 3473581 gttcgcgcaa agtatccata atggaagcga tcgttctggc ggcccgttta tttcgcaaaa 3473641 ctgcgcggca ctgccagaca gccttgtgga aagcattttg tttgggacga aaaaaggcgc 3473701 gtttaccggc gctgtcgacc agcccggcct gtttgaacaa gcccacggcg gcacactgct 3473761 gttagatgaa atcaactcgc tgaatctcag ccttcaggcg aagctgctgc gcgcccttca 3473821 agaacggaaa atcaggcgca tcggttcaac aaaggataca ccgattgacg tacgtattat 3473881 tgccacgatg aatgaagacc caattgatgc aattgcaggc gaacgaatgc ggaaggactt 3473941 gtattacagg ctgagtgtcg tcacactgat catcccgccg cttcgggaac gaaaagaaga 3474001 cattttgctt ctcgcgtcgg agttcatcca gaaaaacaac catctgttcc aaatgaatgt 3474061 tgaacacatc agcgatgacg tgaagcaatt tttcctttct tatgactggc cgggaaatat 3474121 tcgcgagctt gagcatatga tcgaaggcgc aatgaatttc atgacggacg agcaaacgat 3474181 tacggcttcc catctgccct atcaataccg catgaaaatc aagccggctg acatcccaga 3474241 gccggaaaca ccaagacacc agccagccgc ggacttaaaa gaaaaaatgg aaagcttcga 3474301 aaaatatgtg atagagaacg tgttaagaaa acacggccat aacatctcga aagctgctca 3474361 ggagcttggc atcagcagac aaagcctcca atatcggctg aagaaatttt ctcactcgtc 3474421 taacgaataa tccggagcag gaagcctgat cagaaaaaca gtgcctctgc cgatttcact 3474481 tttcacttca atcgtcccat tgtgattgtc gataatcgat ttcgttatgg caaggcctaa 3474541 tcccgaacct ccatatttcc gggagcggga tgggtctgcc ttgtaaaacc ggtcaaacac 3474601 taaaaaacgt cacttcttat gcattgaaga aagaaaatgg cacctatgtg tatcacagcc 3474661 agcaaccaca cggtacaaac cattaaagtc catgcaaata acggaagtat ttgcagctaa 3474721 ctgccatttg ctgtttcacg tgtaacatcc atcttgtatt tttcttcata ttcgatatat 3474781 cctttttcaa ctgaacgggc gtgacccctg ttcagttttt tttgcatatc aaaacagcct 3474841 ggcaacgatg ccagactgct tttattaact gcctaattgg tctgcggagg acagcttgat 3474901 atcaacagat ttttcttttc cgccgcgata aaacttcacc ttcacccggt caccgacttt 3474961 tttctgataa agccgttttc gcaggtcaac aatatcattt actttgtatc cgtcaaattc 3475021 cgtgatgaca tccagttcct tcagccccgc ttttccggca ggtgaaaagg cgtctacacc 3475081 catcacaacc gctccattgg tgacgttctt aggaagcttt aatgtttcat cccaatgata 3475141 gcttgcgatg tcacttagcg atttcatctc aatgccaagg aacgggcgtt tgacctttcc 3475201 gtatctctct aaatcctcta tcacagggat cacgagctta gacggaatgg acaggccaat 3475261 cccttcaacc gctgactcgg caattttcat tgaattgatg ccaatgacct tcccatccat 3475321 atttaacaaa gcgccgccgc tgttcccagg gttaatggcc gcatctgttt gcaggacttc 3475381 agcgttccag tcaggctgtc catcaccgtt tgaatctact gggatcgccc tctccgtacc 3475441 cgagatgacg ccttgtgtga cagagcctgc aaactcaagg cctaacgggt tcccgatcgc 3475501 aataaccggc tccccagact tcactttatc tgaatttccg aaatcagcga ctgctttaat 3475561 cttatcgctt ttcacccgta aaacggcaag gtccatcagc tggtcgctgc cgacaagatc 3475621 agctgataca cgtgagccgt ctttcaagct gatttcaatt tgggaagcgc cttcgatgac 3475681 atgatggttg gtcacgacat aagcggaatg gtcatttttc ttatagatga cgccagagcc 3475741 gctcccagcc tcgccgctct ctccccaaat atctgatttt tggatgttca caacaccgac 3475801 aacggcgggc gacatattgc tgacaatctt ggtgacggca ttgttgacac tgacattcac 3475861 cgtcctgatt gattcccggc cattgttgtt ttgctgctga tctaaggcgc ctgtatccag 3475921 cccttcattt gaaaggtacg gcatgataaa cgccattaat acggcaccga caatcacgcc 3475981 aatcagactc gaaagaaaat atcctttttt gcttctcttt ggctgttcag gagtagtatg 3476041 ttcttcctca cgttcgtaat ccaccatatt ccatcctttc caagaacgtt aatatggtta 3476101 tattgtgggt tagaaactcc tagaatagtc atgatttaca tagaaaaatt atacagcgca 3476161 aagcggagtg gccttcttcg gatcggtgtc gtataagtca aatgtctcac ccgtcacaaa 3476221 tcctttagaa gccaatgtct gctgcacaga cattcttgcc agctccttca tgttgttgtc 3476281 ctggctcaaa tgcgccaggt aaatacgaga cgtctcatcg ccaatgacat ccgtcatcgc 3476341 caaggcagca tcttcatttg acacgtgccc gacgtcactt aaaatccgcc gcttaatgct 3476401 ccatgggtat cttcccattt gcagcatacc gacatcgtga ttgctttcaa acacaaatac 3476461 attcgctgaa cggataatgc ctttcatccg gtcgctgaca tatcccgtat ctgtcattaa 3476521 cgcgagcttt cggccgctat aatggaatac ataaaacatc ggttccgccg catcgtggga 3476581 aacgccaaac gattcaacat caagtccgcc gaacgacttc accgtctcca ttggaaatac 3476641 aaacttttga tcggtgtcaa ttttgccgat ttgattctcc atcgctttcc aagtcttctc 3476701 attcgcatag atcggaagct tgtactttct ggcgacgaca ccaaggccct taatatggtc 3476761 actatgctca tgcgtcacaa aaatgccgtc tacatcatcc agcttacgcc cgatctgcgc 3476821 catcagccca tccatggctt ttccgctcaa accggcgtcc actaaaaatg cgtgatcctc 3476881 tgtttcgagg taaaacgcat ttcccgtact cccgctcgca agtacgctaa attgcaagct 3476941 catgtttgtc tcactccatt attttcattg atctgtatct aaaatcgtac tctccaaagc 3477001 attcacagta aaatactctt gtactgtctt tttctcaccg ttcacttttt tctcgtactc 3477061 gaccgtaatt ctccataccg gcgccagcac ctgcgtactt gtcagcggat attgtgctac 3477121 atagccgaat ttacagctct tcacagtgct gtattctttt aattgatttt gatagtacaa 3477181 tagctcaacc gcatccattt cagtaattaa gctttctttc tggatttgct tgaaggtctc 3477241 aagcgtagtc tggtcgtatg acacaacctc gtttttaccg tttaagtgca gcaccacttg 3477301 cccgatcata ttagagggat tgtcggtctt ttggtaaata taatgacctt cgtacgtttg 3477361 gaagaaaata atttctttct tcgatttatc aaccttccaa agcttatatt tttcgccatc 3477421 ttgaattttc gaagaaacaa gtgcctgagc atcgtcctcg atatccttct ttgatagtgc 3477481 gattggattt gcaaacttca ttttcaggct cgttacttta tgatcatcac taggcatgtc 3477541 catcaaaggc ttttgatcct tcagcgcctc aatttcctcc ttggagaaag acttttgatt 3477601 tgccgtgatc cgatagcctt ctgttgcttc cttattcaag ccttcatacg tgatatgatc 3477661 ggccttcatg tcatgctcga catcattttt aatgacttca tattctttgc cggtagcctg 3477721 ccatttttga aaaaactgat agcctaagaa aatatctaaa atgaggaagg caacgatgaa 3477781 gattgatttt gtcttattcc actccactgt tagccccctc cttcctcaat aaatcctttg 3477841 taatcggcac aatttttcca tttactttca tcgcccaaac cggttccagt tcaacgagag 3477901 gatcatcgtt ggttgatgtt gataccaatt gataagcaag gaagatctga tcaattttgt 3477961 ccgtatcata agcggtttgt ttcgaaagca gcatcttcac ttcgctgccg cccatgagct 3478021 ctgtttcact tgttttaatc ggattcgttc cgagactgta attcggccgc ttatagctga 3478081 gaatatcatc attcgcccat tgcaccgtaa tcgccgatgt cgccccgaaa ggtttggcgg 3478141 tgctgttaat gaccgggatc tgatccataa aaatatagaa gctcaactgc tggctgtcat 3478201 tgatattgaa aaattgatag tgatccgtcc agcttccggt atcctcaagg tatttttggc 3478261 tctttttgat taattcacct gtttgatagg atgtgctctg caccaaattg cgctgctgaa 3478321 attgcacctg tctctggctt agattcacat ctaaccggct gatcccatct gtcagcacat 3478381 ttctgttggt gtaattcgaa tcttctctta caatgctcgg atcactaaac aaagcctgct 3478441 taaaggtatt tgttttaatc gattctgtga caaattcttt tttgtccatc gtaagcggtt 3478501 tgttcggcag caagaactct ttctttgagc caatggagaa caaactgaac gccggcatat 3478561 ttgattgcct gtttttcaag tcgttcataa tgttccggta gtttgctgat tcaaccgtca 3478621 cttcaagaat gagctgcttg ctgtatgaca ccaaatagat tttcttgttc gcttttgttt 3478681 cattgaacgg gatcagaata tggtcaaacg aactgtattc aaacgactga ttagaccatt 3478741 taaacagcgt ttggaaaata tcaatcggga tcgtatcgct gaattgcaag tcaagcttgg 3478801 cttcagaacc gcctattcca taaaaccagc ttttgaatcc agccttgtca tactgatccg 3478861 aaatatcttt aattcctttc acatcccaat gcggcaagtc agaccaaatt tcttcataga 3478921 gggcattgtc atccactttg taatgagcgc cgtcatcatg gataaacatg tcccttggcc 3478981 ttaccgtttc agacagcttt tgggtggttt tttcgatttt atgtttcaca cgaacagtag 3479041 actctgttga ggatgagcct tcagaaaagt ttggctggaa cgtccatatc ccccatgtaa 3479101 aaacaagact gatgacgacg agtaccgtaa gtaatatcgt ttttatattt tcacgcttca 3479161 tcccaatcat cctcttgttc ctctttatat ggaagagtaa atgtaatcgt cgtgcctttt 3479221 ccttctatgc tgtccgccca aatatctcca ccgtgcgcct gtaccatttc cttggcaatc 3479281 gccaatccca gaccggtgcc gccaagcttt ctcgttctcg ctttatccac cctgtagaag 3479341 cggtcaaaga ctttttcgac atcttttttc ggaatgccga tcccttcatc cttcacgctg 3479401 atatagagaa gttcttcctc ttcattgaca tcaatcgaga acgtgacatg tccgccttcc 3479461 ggtgaatatt ttaaagcgtt agaaataata ttatcgagca cctgcgttat tttatcctgg 3479521 tcaatctcga catacagatc tctgtccggc agattgcgga taaactccac atgctgctct 3479581 tttgtcattt caaaacggtc aataataagt gacataaacc ggacaatctg aatccattcc 3479641 cggttaaatt gataatcttt actgtcaaat ttcgacagct gaagcagatc attgacaagc 3479701 cggatcatac gctctgtttc attttgcgtc accattaaga agcgcggagc aatgtcttta 3479761 ttttcccacg cgccttcagc taacgcttct aaatagctgc gcattgtcgt aagcggcgtc 3479821 cgcagctcat gtgatacatt cgcaacgaat tctctgcgtt cctgatccat tttctcttgt 3479881 tcggttacat cgtaaatgac agcgattaaa ccatcaattt tgccgtgttc cctttgaatc 3479941 acagagaaat tcacgcgaag caccgttaat tcatcatcgc gctcaatttc aagcagcata 3480001 gaatcctgct gttccactaa atcttcaaaa gtataattct cttgaagccc cagcaaactc 3480061 gtaatcggca tttctaaggc tgtttcacgt gaaacgttca acagttccag cgccgggctg 3480121 tttaagagaa taatcgctcc gtttcggttt gtggcgataa cgccgtctgt catataagca 3480181 atgacagagg ctagctttct gcgttctcct tcagtcatcg cctgggcatc ttcaagctct 3480241 ctcgttaagt ggttaaacgt tgtggccagc tgcccaattt catcatgtcc atacttttta 3480301 accttcctcg agaaattccc tttcgcaagc tccatcgcct gctttcgcat atctgaaagc 3480361 gggtgggtaa tggttcttgc cagaaaaata ccgagaagag ccgtcaaaac aagtgccaaa 3480421 cctgtgccgg acgccagtat cgtgttgatc gtcttcattt gattaaagac atcttccata 3480481 ctcgcgacaa cgtagatcgc gcccacaacc tcttggtttt cagtcatgac gggcttcgcg 3480541 gaaataagaa ctctgatttt gcttttcggg tcataatatt ttcttaaata cgactgtttg 3480601 gtagaaaaga ttcttttgaa aatcagatcg gtcgtttgtt tcccagccac ttcctcaccg 3480661 tacggctttg aagaaccgac cacttcatag cttttatcta caaagctaat ttcccgaacc 3480721 tcatcacttt tcgtgaagtc attcaaaata cggctgacgt catcctttat gacggtactg 3480781 tcgttatcgc tcttatattc ttgttcgata taataagaaa ggttgtcgat tcgctgattc 3480841 agcgattgtt cataagagct gatcagcgac ttctctacct gattgacaaa atacacacca 3480901 atgatttgca tggcaatgat aatcaaaagc acataaatca aggtaatctt aaattggatc 3480961 gaccgaaaaa aaccaacctt attcatatgg gcattagtcc tgttctgggt ttctcaagta 3481021 ataacctaca ccacggcgtg tgacgatcca atttggatgg ctcgggttgt cctcgatttt 3481081 ttcacgaagc cggcggactg ttacgtcaac cgttctgaca tcgccgaagt aatcatagcc 3481141 ccaaacggtt tgaagcaaat gttcacgggt catcacttgt ccgatatgtt ttgctaaata 3481201 atgaagcaat tcgaactcac gatgagtcaa ttcgattgtt tcgtctcgtt ttgatacaac 3481261 gtacgcgtca gggaagatga cgagagagcc gatatgaatc tcgttagagg aaggctcttc 3481321 ctccgcaggc gctgttgtca gctggcggcg caggttcgct tttacacgcg ccaagagctc 3481381 gcgtgtgctg aatggttttg tgacatagtc atcagcaccg atttcaagcc cgataacctt 3481441 gtcaatttct gaatccttag ccgtcagcat aatgattggc atatcgtatt tctttctgac 3481501 ttcgcggcat acttcaacgc cgtctttatt tgggagcata atatctaaaa gaattaaatc 3481561 aggctgaagc tcttctacca tttcaacggc ttcgtttccg tcgtgggcac agtgcacttc 3481621 atagccttct tttcttaagt taaattccaa tatatctgca atcggttttt catcatctac 3481681 tacaaggatc tttttatcca tcattttgat tttcctcctg ccgaatgact tcatttcatc 3481741 tatataacat tcgtttcatc acttatggcc catgtaaaga atgggtcctt gtctattata 3481801 acggtttaag gtcaaaagat aaaaaaaata aaggtttaga aaaaaaacac atgtttcacc 3481861 tttatcgcca gttgtttatc tattgtcatg ctggtcaact ttttttaaaa aagataactt 3481921 tattgaaacc tcccctcacc ggagtgcgtc tttatcaatg acgtcttctt ctttgaaccg 3481981 gccgcagggc cggttctccc tttttcttct attataacac tcctcatgtt tgcctttttc 3482041 ctaaaagaaa aaacgcacct acgattgcag atgcgtttgg taagtggctc gggacggaat 3482101 cgaaccgccg acacacggat tttcagtccg ttgctctacc aactgagcta ccgagccaaa 3482161 tgttttattt ttctctacta agtaaagtaa aatggcggtc cggacgggac tcgaacccgc 3482221 gacctcctgc gtgacaggca ggcattctaa ccaactgaac taccggacct tacagtaatt 3482281 gcccggagag ctgtcgtgtc agctctcaca gacaaataag gaatttagca ataacgctaa 3482341 agtaaatcaa tgacccgtac gggattcgaa cccgtgttac cgccgtgaaa gggcggtgtc 3482401 ttaaccgctt gaccaacggg ccttcacgaa atggtgagcc atgaaggact cgaaccttcg 3482461 accctctgat taaaagtcag atgctctacc aactgagcta atggctctta aagatgtcgg 3482521 aatttctata gagcaaacga cttaaatcta gttctcatct tgtactctat tgaagcagtt 3482581 tccgtaacaa cgagatttat aatatcacga acaaatagaa gtggcaataa cttttttggt 3482641 tttttttcat atttttttct cagaccaact tatatgcggc tttcaaacaa aaaacaagcc 3482701 ccttaaatag gggcttgcag acatattcta tttagttcgc acggtacaca ctgcgaagga 3482761 catttgtttg tgagcggtct ggaccgacag agaaaataga aagcggaatg cctgtcagct 3482821 gagacacacg ctcaagataa tggcgcgcat tttccggaag ctcgctcaag ctcttcgcac 3482881 ctgtaatatc ctcagtccag cccggcattt cttcatatac cggctcacat tcagcaagtg 3482941 ccttaagact tgctgggaat tcttcaatga tttcgccttt gtagcggtac gccacacaga 3483001 ttttcaacgt ttcaattcct gctaggacgt caattgagtt cagagaaaga tctgtaattc 3483061 cgctcacacg gcgggcgtgg cggacaacaa cgctgtcaaa ccagccgaca cggcgcgggc 3483121 ggcctgttgt tgttccatat tcgcgtccga cttcacggat ttgatcgccg atttcatctt 3483181 tcagctcagt cggaaaagga ccgtcgccga cacgagtcgt atatgctttt gatacaccga 3483241 caacgtgctt gattttggtc gggccgacac cagaaccgat cgtgacaccg ccggcaaccg 3483301 ggttagatga cgtaacaaac gggtatgttc cttggtcgat atcgagcata accccttgtg 3483361 cgccttcaaa taatacacgg cgcccttcat caagagcatc gtttaagaca acagatgtat 3483421 cgcaaacata ctttttaatc tgctgtccgt actcataata ttcgtctaag atatcctcaa 3483481 gtttaaaccc ttctgtctcg tacattttct cgagaagacg gtttttttct tcaagattgc 3483541 gctcaagctt ttccgcaaac gcgtcacggt ctaacagatc cgcgatgcga attccgatgc 3483601 gggctgcttt atccatgtaa gcagggccga ttcctttttt cgttgtgccg atcttgttag 3483661 cccctttacg ctcttcttcc acttcatcca atttcaaatg atacggcaga atgacgtgag 3483721 ctctgttgct gattctcagg ttatctgtac tcacgttgcg ctcatgaaga tacgcaagct 3483781 ctgtgactaa tgctttcgga tctacaacca ttccgtttcc gattacacac gttttatcct 3483841 tatagaaaat tccagacggg attaagtgaa gcttatatgt gattccgtca aacttgattg 3483901 tatgccctgc gttatttccg ccttgataac gggcgatcac ttctgcattt tctgatagga 3483961 aatctgtaat tttacctttt ccttcatcgc cccattgcgt acctactaca actactgaag 3484021 acatgtccgt gcacctccgt taacctttca aaacgattct attcaaacaa atcaagttta 3484081 tcagtgaaga aacagaaagt caattgtaaa tccgaacatt aatttattgt aaatctatat 3484141 tcgttcgctt ccattcgttt tataagcgtt ttctcactgc tttgtcataa aaagcttgcg 3484201 aaactttcat cctttagcat aagaaagaat cacttgcctg atatcccttt tgaattcata 3484261 aaaacgatcc gccagccgtc cgggtcctct atcgtcacgc ccccattgct ccagtacggg 3484321 ttctctgatt cgacctcttg atagcccatg tgctttagct ttgaagtgat cgctgccagt 3484381 tcaactgcat tcggcacata aaaaacaaga aggctgtcgg gatggggaac gggggcagtg 3484441 cttccccctt catactgggt gaattccaaa tgataatcgg catgaggaag gccgaacatg 3484501 acaccgtcat acccgttatg ctgtgaaaat tctcctattc gtttcaaaca cagtccctct 3484561 tcgtaaaaac gaataatctc atcaagctgg cccgtaggac gcgcaattcg gatttgtgct 3484621 gcttgaaaag acgaaaaacg ttttcccata ttgttaccat ctcctttttg caccatttta 3484681 ttaaaacgct ttcaattttt catccgctga gcgaacgtca tttcttccat ctttcgaatg 3484741 aaaaaaaccc caagagcagc tcttggggct tatgcgccgg gcggaacgcc tgcgtcatca 3484801 aaacgccgtt ccaggttgac gaatttgttg tattctttta cgaacgcaag agacacggtt 3484861 cctaccgggc cgttacgctg tttggcgata ataatttcga taatattttt attctcggtt 3484921 tctttgtcat agtagtcatc acgataaagg aacgcgacaa tatccgcgtc ctgctcgata 3484981 cttcctgatt cccggatatc agacatcatc ggacgtttat cctgacgctg ctcaacaccc 3485041 ctggaaagct gagaaagcgc gataacaggg acttgcagct ccctcgcaat cgacttcagt 3485101 tcacgggaaa tttcagatac ttcctgctga cggttgtcct ttgaacgacc gcttccctga 3485161 atcaattgca ggtaatcgat caaaatcatg cccagcccgc tttcctgctt caagcggcgg 3485221 cacttggcac ggatttcact cactcgaata cccggtgtat catcgatgta aatcccgctg 3485281 ttcgataggc ttcccattgc catcgtcagc ttgccccaat cctcttcggt caggttacct 3485341 gtacggagat tctgggcatt gatatttccc tcggcacaga gcatacgcat aacgagctgc 3485401 tcggcaccca tctcaagact gaaaatcgct acgctctcat cggtcttcgt cgccacgttt 3485461 tgtgcgatgt tcagggcaaa ggctgttttc cctactgaag gacgggcagc cacaatgatc 3485521 aagtcgttgc gctggaaacc cgcagtcatc cggtcaagct ccgtaaaccc tgttggaatt 3485581 cccgtgatat caccttttcg attgtgaagc tgttcgatat tatcataggt ctggacaagg 3485641 acgtccttaa tattttggaa ggcactcgtg tttttgcgct gtgccacttc cataatcgtt 3485701 ttttccgctt cactgagtaa atcctcgacc tcatcctcac gggtataccc gtcttgagca 3485761 atcgttgtcg cagttctgat taatcggcga agaatcgatt tttcctcaac gattttcgcg 3485821 taatattcta tgttagccgc tgtcggcacc gagtttgcga tatctgtcaa atatgaaata 3485881 ccgcctactt cttccagcag gtctgtgttc gcaagctctg atgtaactgt caccagatca 3485941 accggttcac ctcggtcacc gagcaccagc atcgcattat agattttttg gtgggacatt 3486001 ctatagaaat catctggaat caatacttct gaagccagtg ttaaagcaga cggctgtaaa 3486061 aaaatagcgc ctaacacggc ttgttcggct tctatatttt gcggaggaag ccggtcattc 3486121 agaaggtctg tcatgctaag caccgtcctc tcattaaaaa atctccaacc tccattctac 3486181 catttctaca gaaaaaaaat agaaaaattg tctgtttcct gtttttttca gttagcagat 3486241 tggatcgttt cggacagtaa caaggcggga aaaatgcaat aaaacataag ggaggaatga 3486301 aagatgataa agaaatatgc gattacacct aatgttgatg cggacggctg gtttattgag 3486361 gtggagaatg tagcgccgac agctttgtat acgtctaaag acgccgctat tgaaaaggcc 3486421 aaacaggtgg ctaaggaaaa cagtccgtct aagcttgtaa tttatgacca gtttaaaaat 3486481 gtggaagaag aacactcatt ttaatgaatg aaagccttcg ctgcagcgag ggttttttag 3486541 cggttatcgg tttatttcat ccattggatg cctatgtgca tcatcaaatc tgccgctttt 3486601 tgatacagat cccactcccc gatcgaagca aatttcccca tcagctcctg aagctttaac 3486661 ctcattgcta tatattcttc gaaagtgaca gctttttcag tgtctatttg gtgttccttc 3486721 agcatttgtt ttaataagga taacggtgcg tgcataagaa ccctccttac ctcttttata 3486781 acggtcattt tccgattgct ctattccttt gtgacatctt cttacatttc acatctgatt 3486841 cttgtacaat ggacagaaga gaggagggat cttttgtgag acctttgcaa atttctgccg 3486901 aaactgcaca aaagcttgca gagtccttga atctgccgct tgaacagatc atgcatatgc 3486961 ctcagcatat tctgcttgcc aaaatggctg aactgcaaaa agaggacaaa tcatagcctt 3487021 cattcacata cttgcttacc tgtttcggga taatatcatg tatatgttag aaaagaggag 3487081 taactgcttt gccacatcca cataataaaa aaatccaatc attttggctg atcaccggca 3487141 ttatctttat cgcctttaac ttacggcccg cgatcacttc agtcggtccg gtcatcagct 3487201 ctatccgggc agagctgcac atgtccaatg gggcagccgg ttttttgacc gcactgccgc 3487261 tgctttcgtt tgcagttctt tctccgcttg cacctaagct tggacagcgc ctcggtaatg 3487321 agcgaacttt atggctaggt ctcgtgatac tgctgatcgg tgttctgact cgttctaccg 3487381 gctatactgc cgctttgttt ttcggaacag cacttatcgg cgtcgggatt gcgattggta 3487441 acgtactttt gccaagctta atcaaacata aataccctga aaagccaggg atcatgatca 3487501 gcctgtatac gacatcaatg aatatattcg cagctttagc atcgggtgtc agcgttcctt 3487561 tagcgaccca gatgaatggc ggatggaaac aagcctttct cttatggggc gggctggctt 3487621 tacttgcatt gctaatctgg atacctcagc tgcgccatcg agatacggca aaccagacaa 3487681 tgaagctgca atccagttcc atttgggctt ccaaaatggc atggtatgtc accatcttta 3487741 tgggcctgca atcgttttta ttttacagca gcatcgcttg gtttcctgaa attctccgtt 3487801 cacacgggat tgatacggca acagccggat ggatggtatc actcatgcaa tttgcgagtc 3487861 tgccttccac ttttctgacg ccagttttag ctgaccgtgt gaaacagcag cgcggtatcg 3487921 ttgcggcgct ggcctcagtt tatctgatcg gcctttgcgg attattagcg ggcggaagcc 3487981 atacattgct tgccatctgg atgatcatta tcggtatcgg acaaggctcc agcattagtc 3488041 tggcccttac tttgattggt ctccgcagtg aaaatgccca acaggccgct gcgctgtcag 3488101 gcatgtctca gtcattcggc tacctgctgg cagcagtcgg gccaatcttt gtcggctatc 3488161 tctttgacca gacgcattct tggacgatgc cgattgtgct tctcattgct gccctgatcg 3488221 taatgggagc agccggacag ggagccggac gagatcgata cattttccag tcagaaaaac 3488281 aaagaaattc agcataaagc ggggaagata tctccgcttt tttctttgaa tatttatggt 3488341 ttattcataa gtttttcata tttgtttttt acaatgagac accataaaga ggtgaaaaac 3488401 gatgaaaacc aaacgattcg acgcagccct tattcttatt ttgctagcag cagctttttt 3488461 gaatacgtat cacatttggc aggatgatac agcaaaccag tactatttgg cggctgtaaa 3488521 aagcatgacg caaagcttcc ataacttttt ttatgcgtca tttgaccctt ctggatttgt 3488581 gacagtagat aagcctcctg tcgtgttatg gattcaaacg attttcgcac tgattttcgg 3488641 tgttcacacg tggagtgtca tcattcccca ggctcttgcc ggagttggat ctgtcttcct 3488701 tctctacaga atggttaagc cgacttttgg agttggagcg gcccgcattg ccgcacttgt 3488761 catggcactg acccctatcg cagtagctgt cagccggaca aacaatatcg acagcatgct 3488821 tgtttttacc ttattgctcg gttcaacttg tctgcttagg gcagtaaaac aaggcaagct 3488881 ggtttggctg ctgacggcat ttgccctgat tgggctcgcc tttaatatga agatgatgca 3488941 agcgtttatg gtattgcctg catttgtgtt attctacctg attgcatctc gggtttctct 3489001 gaagaaaaaa atcgggtccc tgcttctgtc tcttgtcctt ctgacaggcc tttcactctc 3489061 atgggcgatt gcagtggatt cagcctcttc ctcaagccgg ccttatgtag gaagcagcca 3489121 gactaactca gtgctagaac tggcctttgg ctacaacggc acagagcgtc tgtttgggca 3489181 aactacgggc cttgcaaagg gtgatatgaa tgctgctggc ggagggaaca tgcagaatca 3489241 agacaacatg caagcgccaa atggcaacgg ttcatctttt tctcagaacg gtaatcaatc 3489301 attcggaaac cattcacagg cgcctcagcc gcctaacgga caaaccggcg ctctcaatgg 3489361 aggcggaggc acacctccca caggtggcaa cggacctgga aatggagggc ctggcggcgg 3489421 aggcggaaaa agcgtgaata tgttcggcac cggtgatcct ggaccgcttc gtctcttcca 3489481 atcagcactt tccggccaaa tcagctggat gcttccattc tcattgatcg gattactggg 3489541 cgcaatcatc agctggtacc gtgatcgccg cggacatgct gctaaaatga aagaaacgct 3489601 attctgggcg gcttggcttg ttcccgtggc tggtttcttc agcatcgcag gattcttcca 3489661 ccagtattat ttgattatgc tggcaccgcc gattgccgcc ctttctggta tcggatggta 3489721 tacgatgcac cgcttataca aaaataataa agactggtcc agctatcttc tgccggcagc 3489781 cgtcttgatc acagccgtgt ttcaggtgta tattctgagc gcttatacaa gccaaatcgg 3489841 cagtgtatgg atgtatgtcc tggggctctt aggactgggc atcacccttg cacttctgat 3489901 gcttaaacgc agccatccgt tcagtaagct gctgaccatc atcagcttgt gcgttctgct 3489961 tctcacacca gtttactggt cagcaacgcc gcttctatac ggtggcaaca gcgtccttcc 3490021 tgaatccggc ccgcagctca aaggctcagc aaacggcggg aacatgttct cttcagaggt 3490081 cgacagcggg ctcctgtcct atctgagaaa acacaatacc ggcgaagagt atttatttgc 3490141 tactttgaca accgtaacag ctgcgccata catcatttac gaaaatgaat ctgttatggc 3490201 aatgggcggg tttaacggca cggatcccat tctgactgtg tcggaactga aaaaactgat 3490261 caaagaaggc aaagtgaaat acttccttct gtcagaaaac aactcaggca acagcgaact 3490321 tgtttcctgg attaagaaaa acggaaaaga aataacatct gacgagtaca gcggttcctc 3490381 cagcagcaca aacagcgtgc agggaatgcg aagaggacct ggcggagaaa gccagcaaac 3490441 tctttatctc gtggaataaa aaaagaggct tggatgaatc caagcctctt ttctattaag 3490501 cttcttcttt tacatgtacc tttaacacag cctgcacttc aggatgcagc ttcacaggca 3490561 cgtttgtata tcctaatgca cgaatgccgt ccggcagttc aagcttccgc ttatctactt 3490621 taatgttatg gtctttttgg agctgttcag tgatttgctt gcttgtcact gaaccaaata 3490681 aacggccgcc ctcacctgat tttgcgctaa gctcaacagt cagtttttct aatgtctctt 3490741 tcaagctctt agcctgctca agctcagcaa tggcttcttt tttctctttc tgcttttgtc 3490801 cgtttaacgc gctgatgttt gacgcgttcg cttcaaccgc gaggcctttt ttaattagaa 3490861 agttatgcgc ataaccgtct gctacgtttt tgacttcgcc tttttttcct tttcctttta 3490921 catcttgtaa gaaaataacc ttcatctctg tacgcctccc tcaaaatact catctatggc 3490981 gtgcttcagc cgttccagcg cttcagaaac tgaaatgccg gacaactgag tcgccgcatt 3491041 tgttaaatgc cctccgcctt ccagggcctc catgatgatc tgaacattta cctcgccaag 3491101 cgaccgagca ctgatacaaa ccgtttgttc atcccgtctc gccaccgcaa atgaagcctc 3491161 aacctcactc atcgatagca gcgaatcggc agcctgcgca atcagcactt gatcgaagta 3491221 ttcctcttca ttttcaggaa gagaagcaat cgcaatgtta tctttataga ggaccgtatg 3491281 ctggatcagc ttcgcccgtt taatatagga atcaacggtt tctttcagaa acttctgcac 3491341 cagcaccgtg tcggcgcctt ttgcccttaa ataagaagcc gcatcgaaag tccgcgagcc 3491401 cgtgcggaga gaaaagctct ttgtatccac tattatacca gctaataggg ctgttgcttc 3491461 aatcatattg atttttaagc gcttcggctg atattcaagc agctctgtca ccaattccgc 3491521 tgtggaagaa gcgtatggtt ccatataaac gagcagcgga tctctgataa actcctcacc 3491581 tcttcggtga tggtcgatga ccacgatatg ttcaatttta ttgaccagcc gttcctccat 3491641 gacgagtgac ggcttatgtg tatcaacgat cacaagcagt gtgtcatcat tggaaatctc 3491701 cattgcttct tcaggcgtaa taaatcttga ccacagttct tcatattttt tgatttcccc 3491761 aatcaaacgc tgcacacttg atccgatttg gtttgggtca atcacgataa aaccatcttt 3491821 gttatttgcc tgagccacct ttaaaatccc gatcgctgcg ccgatagaat ccatgtcggg 3491881 gaatttatgc cccatgataa tcacattgct gctttcggtg acgatttcct ttaaggcgtg 3491941 agaaatcacg cgggcccgca cccttgttcg tttctccatt gggtttgttt taccgccgta 3492001 aaacttcacc ttgccgtttg gcagcttaat ggctacctgg tctccgccgc gtcccagtgc 3492061 taagtccaag ctggattgcg ccaaatcgcc aagttctttc agggaagaga ctgaagcccc 3492121 gacaccgacg cttaacgtca gcgctacacc gtcaaacgag gttttttccc gcacttcatc 3492181 aagaatcgaa aacttcgaat tttcgagttc agttaagata tgttcattaa gtacagcaat 3492241 aaagcgttct gaagacgtcc ttttcaagaa gatcccgtac tcctgcgccc aagcgttcag 3492301 caaagatgtc acctggctgt tcatcgtgct tctcgtctgg tcatccaatc cttgtgtcac 3492361 atcatcatag ttatcaagga aaatatatgc caggacggtt ctttcgtttt catatagctt 3492421 ttcaatctgg atttgttctg ttacatcaaa gaaatataag agacgctcat cccgtttgat 3492481 gacaacccta aacttgcggt cattcaatgt aaccgtttcc gattccacct cttgtttgat 3492541 aagcggcact accgattcac aagtatcgta aagtgatctc cccactaaag tgctttcatt 3492601 aaaacaagag gaaagaaacg gatttgccca ttctatataa tattggtcat taaaaagcat 3492661 gattccaatc ggcatttcca tcaatgcctc ttcaccgact tttttcaacc tgtaggacaa 3492721 cgtagaaata taagcatcaa tctcttgtcg aataagagaa tcagcacgct taataaaaaa 3492781 caaaataact gccagcagca gcacttcgac ggttcctaat atccagttaa aataaaagct 3492841 gatgaggatt gtaataattg acagagcaat caatgcatag atgggatacc gaaacagcgg 3492901 tttttcataa aagcttggca tttctatcac tccccaccat gtgagtaaaa ctcatgttca 3492961 cttcacctta ttccttatat gaaagcccat atctaaaacg cctaaaatgc gaatggccgc 3493021 catgaagacc ggatgcacaa acccaagtat gacagcaatc acagccgcag cctttggata 3493081 ttgtttctta tggcaataga aaaagataaa tgataaacct tggatgaaaa tcagaaaccc 3493141 gagtataaac tccccattta aagcgataga gtacagcatt tggccttttt ctaaaggcaa 3493201 aaatgaaagc atgacaataa tcaaatacag tactacaaca ctttgcggaa acttcaactc 3493261 tctaaaaggc tttagattag gaatatcggg ggagaatcgc cttaagagcg gcttagcgat 3493321 aaggtaactg aggaaagaaa aaataactcc taccatcaca atagctgttg gaaaaagata 3493381 ttgaacgata cccaattgtt cttccatcag ttttaattgc ttctcaaact gcccagcatt 3493441 gcccgactgc ttcgctacag tttctacaat atcaagagat tgccggtatt gtgtcattgc 3493501 ctcatcaatg atattgatac ccaaaaactg aatgcttatc acaaaataga agacaatact 3493561 aagcatataa ataagagcgc ccgaaataat ggcgtgcccg ggctctttcc ttttgaaaaa 3493621 atgtcccatg gcaatgccgg cgcaagctga cataaaagct acaataagcc cgttaaagga 3493681 cccgacaata aaaacaaccg gaagactgac agcgcccatc catatcccta gcttcaatcc 3493741 atgtctgatc gtatacaaga tcattggcag cggcagtgca aataacagaa ttgttccaat 3493801 cacaggaaca taaacgacca gaagcgtaat gatcgcaaac agactgatta aaatagcacc 3493861 ttccattaaa gctctcgttt gtttcactta gtcacctcgt atcatcctga acatacgaat 3493921 agaaaagagc agcataaacg actgctcttt tgttcatcgc tgcaacatgc tttgcaccga 3493981 atgtttttat atcatctcta aattttactt ttatatttta acataagtcc aaatcgcaag 3494041 taaaatgacg ctaatgtttc atgtgaaaca tgaaaaagga aaagacattc tttgaaaaga 3494101 atgcccatca caattaatgt ttatcatcca taaagccaga agattccttg tttttctttt 3494161 tcgtttttct gacatacata aaaattaaga tcaccagtaa aagggttgtt gcttgcagaa 3494221 cgccgctgct aaacaagaaa aagttcttta tcatgtccca cattgtgttt cacctctttg 3494281 tgcatgttct caacccgtat cctatataag gtgaatttcc ctttttaaaa acttcaaaac 3494341 atcatgaaca acattgagcg ttgggcatat gctgatatgg aatctgatcg ataaaggaga 3494401 attttcacat ggatgaacgc agaacattgg cttggcatga aacattagaa atgcacgagc 3494461 tggttgcttt tcaatcaaac ggactcatta aactgaagaa aatgataaga gaagtaaaag 3494521 accctcagct cagacagctt tataacgtgt ctattcaggg tgttgagcaa aatttgagag 3494581 agcttcttcc gttctttcca caggctccgc acagagagga tgaggaagaa gaacgcgcag 3494641 ataacccatt ttacagcggt gacctgctcg gttttgccaa aacatctgtc cgcagctatg 3494701 ccatcgcaat tacagaaaca gcaacacctc aattaagaaa cgtactggtc aaacagctga 3494761 atgctgccat ccagctgcac gcccaagttt atcgatacat gtatcagcat ggatattatc 3494821 cgtcttacaa cctttctgaa ctgttgaaaa acgatgtcag aaacgccaac agagccattt 3494881 caatgaaata aaacaagcag caaaggagtt ccctttgctg ctatttctgc tgatccttca 3494941 ctaagccgtt cgaacgataa gattccagca cgtctctgtt ggattctccc cattctttca 3495001 tttgcaaaac aatcggttca agcgtgcgcc caaattccgt cagagagtac tctaccttgg 3495061 gcggcacctg gtgataaacc tcacggtgca cgatgccgtc cgcttccagc tccctcagct 3495121 ggagagtaag cattctttga gtaatactcg ggcagattcg ccgaaactca ttaaatcgtt 3495181 tcttgccatc tatcatgtga taaaaaagaa ttcctttcca ctttccgcca atgacatcta 3495241 gagtgaattc aactggacag ccttctttgt tcgggtatat attctttttt tcactcattc 3495301 ttgaccctcc aatagtacct tttttgatac tacattacat tttgcaacta atctacccag 3495361 tattttacac accttttctc cttagctcaa agaaaatgct tcttattcac atcaattttt 3495421 aagggtttgc atgattacac ctgcagcaag acgtgttaaa ctatataaag attacactac 3495481 ttaaaaaagg ataggagcta tcatggaaaa gatacttatt ttcggacacc aaaacccaga 3495541 tacagatacg atttgttctg cgattgctta tgctgatttg aaaaacaaac tcggcttcaa 3495601 tgctgagcct gtccgcctcg gacaagtcaa cggcgaaaca caatacgcgc ttgactattt 3495661 caaacaagaa agcccgcgtc ttgttgaaac agctgcaaac gaagtaaacg gcgttatcct 3495721 ggttgaccat aacgaacgcc agcaaagcat caaagacatt gaagaggttc aggttttaga 3495781 ggttatcgac catcaccgca tcgctaactt tgaaacagct gagccgcttt actatcgtgc 3495841 tgagcctgta ggctgtacgg ctaccatctt aaacaaaatg tacaaagaga ataacgtgaa 3495901 aatcgagaaa gaaattgccg gccttatgct gtctgcgatc atttctgatt ccctgttatt 3495961 taaatctcca acttgcacgg accaagacgt agcagcagca aaagagcttg cggagatcgc 3496021 tggagtagat gctgaagaat acggcttgaa catgttgaaa gcaggcgctg atctaagcaa 3496081 aaaaacagtg gaagagctca tttctcttga tgcgaaagaa tttacactcg gcagcaagaa 3496141 agtcgaaatc gcacaagtaa acacagtgga cattgaagat gtaaaaaaac gccaagctga 3496201 attagaagct gtgatctcaa aagttgtggc tgagaagaat cttgatctgt tccttctcgt 3496261 tatcacagat atcttagaaa atgattcact tgctcttgca atcggtaacg aagcagcgaa 3496321 agtggaaaaa gcgttcaacg ttacattaga aaacaacaca gccctcttaa aaggcgttgt 3496381 ttcccgtaaa aaacaagtcg ttcctgtctt aacagacgca atggctgaat aagccattac 3496441 aattgcttca aaatccttgc ggggtttccg cctacaacag tattagcggg tacatcctta 3496501 gtgacaacag atccagaagc aatcactgcg ttatcaccga ttgtcactcc cgggttaatc 3496561 accgcccggc ctccaatcca aacttgatct ccaattgtca caggcttacc gaactccttc 3496621 ccggatttcc tttcgatcgg atcaagagga tgaccggccg tgtagatatg tacacctggc 3496681 gcaatcaaac aatgacagcc gatacgcacc tcacacacat ctaaaatgac acagtcaaaa 3496741 ttaacaaatg tatgatctcc gatatgaatg tgatagccat aatcacagcg gaatgtcggc 3496801 aaaatcgtga cttgatcccc aaccgaaccg agcagctcct tcaaaagctt cgtccgcact 3496861 gcatcatctt ccggtgtttc gttgtattgt ctaatcagct gtctcgcatg cttgcgttct 3496921 agtaatagtt gttgatcttc cgaattgtat aattctccgg ctgccatttt ttctttttct 3496981 gtcctcagca tttaagtcac tccagatgtc agattgtaat ctcgatcaaa tttccttcat 3497041 catcctcaat cacgctttca tagtagccgt ctcctgttgt cctcgggccg tttactactg 3497101 cgaaaccatc cgccttcaat cgatcagtca gttcgtcaac tttctcccgg ctcccaacgg 3497161 aaaaggcaat atgtgcccag cctgtcattg tttgtgaggg cggatcggtc acattccctt 3497221 ttttcataat ttccagcctt gctccggaat caaacgtaat aaaataagac ttaaaatctt 3497281 ttttctcatt atgatacaaa tcattcgctt cgccattaaa atacgattca taaaaagact 3497341 tcattcgctc taaatcattg acccagaccg ctgtatgttc aatctgcatt tcttcctcct 3497401 ccttcgcctt caatgaagtt ataaggtatg aaatgcattt cagttcaagc ttttttctta 3497461 aatttatgct gaattttgat atcagcgggt tcatcctgca aaaatagaga aaatgctgcg 3497521 atgccgagct gctcaagatt caaatcaagc gacggaaaac caagaacacg gctgatagaa 3497581 gtatttccct cgcctatgat ttcaacatcc caattattct ttttggcaaa tagatgaatt 3497641 ccagctgcca cttcatcact atttgcataa atagcagtcg gaacccgccc gctcatataa 3497701 aaatgttcag ctgccagctc accatcattc atatcgttgc atccggacag catatggcgg 3497761 tcttccaacc ttccgcagac agctttatag gccgcagctt tatcagccgt gctcgggctc 3497821 ctatcagctt ctctgacaca cgtaaaagca atattctcat gcccgcggct ctttaaatag 3497881 cgaaagctct ctgcataagc agtttttctg tcattaaaag cacaagggac atcaatgtct 3497941 ccggtatcct cacaagcgat gaccggccca tattcctgat aagctaaaat gctgtcccaa 3498001 tgattggcgc gggaagtaat gatgagaccg tctattttct tcgttcttaa cagctctaaa 3498061 tatttgattt caatatcggg gttataattg gtggggagaa gggtcgttgc atactcatgc 3498121 tgaaaagccg ccttggtgat tccgttaacg attttatcaa agcagggatg atcgctataa 3498181 ggcagaatca caccgaccgt atgggttttc ccgcgaatga gatcgattgc ggttcgattt 3498241 ggtgtataat ccaattcctt catgacttga tgaacaagct ttctcttttc ttcagataca 3498301 tacggatgat gattcaatac acgcgagaca gtcgaaacag atacatttgc cagtcttgcg 3498361 atctctttta tatttgccat ctctttctcc ttttcatata aaaaaagcag taagtgtaaa 3498421 atccttactg ctatctcatc atatattgat gataagttca acaggacaat ggtcggaacc 3498481 catgacgtcc gctgatatgc tggcatcttc aatctgttcc ttaaggcttt cagaaacaac 3498541 aaaataatca atccgccatc caatatttct gtcccgggcg ccggcacgat acgaccacca 3498601 ggaataagcg ccttcaagat caggataaac atgacgaaaa gaatcaacaa agccagcttc 3498661 taagaaacga gtgaatgcct ctctttcttg atctgaaaat ccagcgttat tccggttcgc 3498721 ctttggattt ttcaagtcaa tctcctgatg ggctacattc aaatcaccgc ataaaatcac 3498781 tggttttttc tgatccaatt caagaatata agacagtaaa gcctcttccc attgcatgcg 3498841 gtaatcaatc cgctctaatc cccttctgga attgggcgtg taaacagtca tcacaaacac 3498901 gttttcaaat tccagcgtaa tcactctgcc ttcttggtca tgctcttcta ctccgatacc 3498961 gtagatgacc tgcagcggtt cttgcttaga aaaaacagct gtgccggaat atcctttttt 3499021 cactgcataa ttccagtaca catgatagtc ttcaggctgg agatcaacct ggccgtcctg 3499081 tatcttcgtt tcctgaagac atataatatc tgcatcctct tctttcaaat aagagaggaa 3499141 atccattttt ctcatcacag cccgcaggcc gtttacattc catgaaatca acttcatgtt 3499201 tcatcctccc ccctataaaa aagagcaaga acccgaaggt ccttgctctt tacatatcag 3499261 cttactcacc gcttacgtat ggaagtaaag ccatttgacg tgcgcgtttg atcgctgcag 3499321 tcaatttacg ttggtattta gcgtttgttc cagttacacg acgtggtaaa attttaccgc 3499381 gctcagaaac aaacttttta agaagatcta catctttgta gtcgatgtgc gtgataccgt 3499441 tagaagtgaa ataacacact ttacggcgtt tcgcacgacc gcctctgcgt cctcctgcca 3499501 ttgtcatttc cctcctttct ttttcatttt aggcgataat cacattagaa tggaagatca 3499561 tcatccgaga tgtcaatcgg tttgccgtcg ttggcaaatg ggtcatcatt aaagctgttc 3499621 ccctgattgc gtctctggtt gttttgattt cccccaaatg gattatcatt ttggcctccg 3499681 ccaaagtact ggcctccgcc gctgtttcct tcgttgtatc cacctgaacc agaaccgccg 3499741 ccgtttttcg gctcaagaaa ttgaacactt tcagcttgga cctctgtcac gaagacacgc 3499801 tgtccttgct ggttttcata gtttcttgtt tgtaaacggc catctacgcc tgcaaggctt 3499861 ccttttttca agaagtttgc aacgttttcg gcttgtcttc tccaagtgac acaattaatg 3499921 aaatcggcct cacgttctcc ggactggttc gtaaatgtac gattcacagc aagagtaaac 3499981 gtagcaacag ccgcaccgtt tggcgtataa cgaagctctg ggtcttttgt cagtcttccg 3500041 actaatacaa ctcggttaag cataagaaag accacctttt accattatat atttcaaaat 3500101 tgcttattct tcttctttaa caacaatgtg gcgaatgata tcgtcactga tcttagctag 3500161 acggtcaaat tcttgaactg ccgcagcgtc agattgaacg tttacgattt ggtagaaacc 3500221 gtcgcggaaa tcgttgattt cgtaagcaag acgacgttta ccccaatcct ttgttccagt 3500281 gatctccgca ccgttagaag tcagaacgtt gttgaaacgc tcgataactg cttttttaga 3500341 ctcttcgtca atgtttgggc ggataatgta cataacttcg tactttctca tctgtttgca 3500401 cctccttttg gactaagcgg cccataatgg gcaaggagca ataattctat tactcacaat 3500461 tttatattat accaaagctc ttgtcccttt acaactgcat cctatacatt aaatcggaaa 3500521 tgaataacat ctccgtcttg gaccacatat tctttccctt caaggcggac ttttcctgcc 3500581 tctttagctc ctgccatacc gccgcccgca agaagatcct cataagcaac tgtctcagca 3500641 cgaatgaagc cccgctcaaa gtcactatga ataattcctg cacactcagg ggctttcatg 3500701 ccttttttga atgtccaagc tctgacttcc tgttctccgg ctgtgaaata tgttgcgagg 3500761 ccgagaagag agtaagacgc tttgatcagc tgatcaagac ctgattcttg aatgcccagc 3500821 tcttccaaga acatttgctt ttcttcgcct tcaagctcag cgatttcaga ttcgattttt 3500881 gcacacacaa cgataacttc tgcgttttcg ccggcagcgt actcgcgaat cttcgctaca 3500941 ttttcattgc cagatggatc agcaacttca tcttcactta cgttggccac gtacaaaata 3501001 ggcttcgaag tcagtaaatg gagctgcttc acaagctttt gctgctcttc agtgaattct 3501061 acagatcgag caggcttttc actctcaaac gcttctttca gtttagataa aatctcaaac 3501121 tcaaatacag cgtctttatc tttttgcttc gcaagcttgc tgacgcgtgt aatccgcttt 3501181 tcaactgttt ccatatcagc gaggatcagc tcaaggttga tcgtttcaat gtcatcaatc 3501241 ggatcaacct ttccggaaac gtgtgtaatg ttgtcatcgg aaaaagcacg gacaacgtgg 3501301 caaatcgcgt caacttggcg aatatgagat aggaacttgt tgccgagtcc ttctccttta 3501361 gatgcgccct ttacaatccc tgcaatatca gtgaattcaa aagcagtcgg cacagtcttc 3501421 ttcgggttga ccagctcagt cagcttttgc agacgatcat ccggcacctc tacaattccc 3501481 acgttcggat caattgtaca gaacgggtag ttggctgatt cggcaccggc ctgtgtaatt 3501541 gcgttaaata gtgttgattt tccgacgttc ggcaaaccaa caattccagc tgttaaagcc 3501601 attctttcat ctcctctata taaaaccgtc attgtatgaa cgtattttga acctagagca 3501661 attataagga ggttcactgg aaaagacaag ctgacaaaaa agcattttca gcttgccaat 3501721 ccctttgatt atgctttttt caagcctact aaacagtcaa aaagcgtact tcccattcca 3501781 ttatcagaat ttgtatcatt tgtcagtgca ttgactgacc ctccaaaagc cgcccacatg 3501841 ccttcatcta tattaatcgt cttcgcatga gcctgcttca tcactttcac cttgcccttc 3501901 atgcttccgc ggtcattaaa gatgacaact tcgtctccat cctgaagatc ctgcccagcc 3501961 gctatatctg gagaaatatc gacctgaacg tgctgaagct tttcaataaa cggcacatgc 3502021 tgtgaatgat tggaacgctg cggatgaatg gataagagcg tataagggta ctttccagct 3502081 aactcctcat tatggaaaac agattcttcg ggcacattta attgaagcga gccgctaaat 3502141 cctttttgct cagctagcga cgaagtaaat tcaaattttc cactcggcgt caaaaactga 3502201 taatcatccc acggcacctg ttttactgga agagggaggt ggcctttttc ttttaaacgc 3502261 tcaagtgtca catcctctgc ttccaatgaa gaaagcccca tctctaaaaa ttcttgagtg 3502321 ctgtattcaa acagctcgcc aaacccaaga cgttttgcaa gctctgacca gatccagctg 3502381 tccgatttcg cttcaccctg cggctccaca agcttcttcc cgtactgaac ataatgatga 3502441 tacatactgg aatagtagat atcttcttct tcaaaaacag tggcagtcgg caaaacataa 3502501 tcacacagct ctgcggtatc cgtcataatg gaatcaatcg cgaccgtcat tggaaccttt 3502561 tcaaatgctt gtctcacctt atttgtattc ggcacctgag tcagcggatt tccgcacgtc 3502621 acaataatca tctcaatcgc aggatcagca gcggtcaaca cttcttcagc ctgtgtcatc 3502681 attgaaaaag aacgggatgt tgtttttaat tccggcagcg tcagctttgt ttttgcaaag 3502741 ctctcaccaa tctggacatt tccgaaattc gcgccgccgc ccttaattcc gacatttccg 3502801 cttgccgcca caagtgcatc aatccaacga atcgttcccc cgccgttttt atatcgctgc 3502861 atgccaagcc ccataaaagt agacaccgga ccatcagcat acaaacctgc caaatactcc 3502921 agctcctcca tagaagtttc tgttttcaca ataaactctt ccagagaaac ggtcttcaaa 3502981 agctctttca catcatcaaa accgacagaa tgctcagaaa taaacgtttc atccgttctt 3503041 cccatctcaa tcagaacctt caaaacggct gccgcaagcc agccgtccat tccaggcttt 3503101 acagagatat agcggtcggc aagcttagca gtcgggttga agatcggatc aatcaccgta 3503161 atcgtggcgc ccttcttttt cacctgctgc aagtgatggt ataagtgcat atttgttctt 3503221 gatacatttc ttccccacac aacaacatgc ttgctgttgt aaatatcaag cggtccgtga 3503281 ccgtacgaac ggccaaaatc ccagctttgc gcctcgatac cggagcccca gcatatgctt 3503341 ccgacgattt cggtcacgcc gccatatcca ttaaaaaaac gctgatcaag cgcttttaac 3503401 agaccgttat tcgcataatc atggctgtgc aaaacagcag tcgtctccga cgtttccttg 3503461 atttcccgaa gtttatcggc aatttcatca agtgcctgct cccaagaaat ccgcacaaac 3503521 tcgccatttt gttttttcat tggatagcga agccgatcag gcgaatttgt ttttgtctca 3503581 agcattctgc cgcggccgca gattttacct tccgtaatcg gatggtttgg atctccgtcc 3503641 acttttgtta cctttccatc atcaacagtc accaaaaagc cgcagctgtc ccaacaattc 3503701 agcggacatg ccgactgatg cactttgctc atcgccgtct tctccttacc ttctatatga 3503761 aaaagcatga gtgtcggcct atttatgaag taggctcctc atgcttgact agtacttttt 3503821 ttagttttct ttcaaattct cttctcggaa tcataacact gtgagagcat ccctcacact 3503881 taattcgaat atccattccc atgcgtataa ttttccagct gttcgctccg catggatgcg 3503941 gttttttcat ttctacgata tcattcaggc caaagtcttt atccgccaag acccttcacc 3504001 tcttttccta aactgctgta tctattgtac aaaaaaactg atcataagag caatcaagat 3504061 acccgaaaag aaatacatcc tcttatttcc atttactcaa aataggatat aagagcagac 3504121 aaactaacaa atacaaattg agcatcccat atatcggata caagaacgcg atcaaatcag 3504181 aaaatccgaa agaagtaaaa ggtaccatta acactaacaa aatcaacaca atcatccatc 3504241 tcggcatatg aataaacgcc atcagccggc tggacaaacc cagcaaacca gctaccgtcg 3504301 tcgtgtaaat cgccaggcac agcaccgccg tcatacataa aaaaaggaaa taaggcgcac 3504361 cctccagaac ggcaaacagc ggtatttcaa actgagaaag ggagcccgcc agctccacca 3504421 acgtttcatt ataaacaaat gagatcacgc caaaaataag accgcttgcc acacttgcga 3504481 tttttgcttc tccgagccct ttcatctctt tcccaacaga ggataaaatc gcaacaactg 3504541 aaaggatgtt taaagaggta aacgtaatgc tcgcaggcca gttatactgc tgggacaaat 3504601 caatcgtcca cgtatggtga tgtgtgctct gaaaggagat cagcgcatat aaaagccccg 3504661 ctactaacac aggaatcaaa atactattta tagataatat tcctttcaca tcccacaaaa 3504721 acaagcacac tgtcacgatg caaatcagcg tgattcccca ccagaaagga agcttgtaca 3504781 tttgcagggt cacaccgcct ccggcaatca tcaccatagt cgtcgaaaac aaataaaaaa 3504841 tgatgaggac atcataaatt ttcgccagcc atggccccat taaatgctcc agaaccggca 3504901 gaaaatgagt ggattgaacc ttaaaactga ttttcatcac aatataagac gagaaaatga 3504961 acataattgt aaacagcaca atagcaagtc cgctttccgc cccaaaaaac tgccatatct 3505021 cctgaccgct cgcatatccg gccccgatca ggctccctaa tatgagcagc atccacttca 3505081 ttccggctct ccacaacact atcacctcat agacaaagtt cagcttgttc ccgttattgt 3505141 tactatataa ataaaggaaa gcaaacatgc catattttca tagacatttg aacacaagct 3505201 gaaattatca tacgaaatac acataaaaaa gactgctaat acggcagtct aaaaagagat 3505261 atttatttgt ttgtccgcgg aatgaagaag tgaacttcac tcttcacttt tttctaacca 3505321 ttcctaccta ttcaagtgtt tcataagcag accattgctt gatcatgatc gaggcaatgg 3505381 gggacaatac ttgtaatcgc ccactaacca ttcatatcat gccctctact tttttaaaat 3505441 ctctggtgcc atacacaaag cataaaaaat catactgctg gatatactgt aaacaacctt 3505501 acataactac acacaccata gcaattctgt tacctactat aacaaggaag tgaaacccat 3505561 gaatcgaaaa ggcgggcttt tttcttctca ggaacgagta aagcaatatg tttcacatac 3505621 agatgctgca gcggcaaaac aaatccaaac catcctttct tcatccttac gtaaagctgc 3505681 tggcaaacca attgtcgtgg tttgtatcgg aacagaccgt tcaaccggtg actcattagg 3505741 cccgctcgta ggaatgaaac tcaaacagat gcagctcacc agattccatg tctacggaac 3505801 cttatctgac cccgtccatg ctgtgaacat gaaggataaa atcaatgaca ttcataaatt 3505861 acataaaaac ccatttgtta tagcagtcga tgcatgctta ggccgcgtta agagtgtggg 3505921 ttcatttcaa atcggggacg ggccattaaa gcccggagcc ggtgtacaaa aagaccttcc 3505981 tgaagtggga gatcttcata ttaacggaat cgtgaatgtg agcggtttta tggaatattt 3506041 tgtattgcaa aatactagac tcaacttggt catgaatatg gcaaatgttc tagcggaagg 3506101 tttgagttta acagatcgga cagagtggag gcaagaacgc cttaacccgt tgcaaaggct 3506161 cactgggcgc atataaaata aaaaccatct tcgtttgaaa gatggttttt tcatttatga 3506221 ttctcgttca gacaaaagct ctaaaatccg gtcaaggtct tcattagaga aaaattcaat 3506281 ttcgattttg ccttttttct tctgtctttt aatattaact gttgttccaa aataattttg 3506341 gagataggat tcccgttctt ttagaaccgc atctttcaca ggttcttttt tctttgtttc 3506401 acgtggaaca ttctgattca actgctgaat cagctgctca agttggcgaa cattgagctg 3506461 ctccgcaatc actttttgta ccagcggttc aagcttattt ttgtttttta agccaagaag 3506521 cgtgcgtcca tgtcccatag aaagcgtgcc ttcggcaata agctgttgaa tattttctgg 3506581 cagtgtcagc agtcttaaat gattcgcaat atgcggtctg cttttcccaa gacgtttggc 3506641 aagctgctct tgtgtgagat ctaagtgttt caaaagggag tcatatgcct gagcctcttc 3506701 aagcggagat aaatcttcac gctgaaggtt ttctaataaa gcaatttccc tcattaacgc 3506761 ctctgataat tcacggacaa tggccggaac tgtatctaaa cctgccagct ttgccgctcg 3506821 aaaacgccgt tcacccgcaa caatatcata gccttttaaa gattttctga cgataagcgg 3506881 ctgaagaatg ccatgctgca gcacagattc ttttagttca gctaatgcct cgtcatcaaa 3506941 gtgttttctt ggctgataag gattagggcg taaatcggca attttaattt cttcaactgt 3507001 ctcttcagac aaatctacct gattaaataa cgcattaatc ccttttccaa ggcctttagc 3507061 cattcgcagc cacttccttt gctaaatcta aatatacttc cgcacctctt gaccgcggat 3507121 cgtataaaat gatgggtttt ccgtgactcg gtgcctcact cagacggaca ttacgcggaa 3507181 taactgtctt atatacttta tccctaaaat actttttaac ctcttcaatc acttgaatgc 3507241 caaggtttgt ccgggcatca agcattgtca gcaatacacc ttcaatcatt aaatcagtat 3507301 tcaaatgctt ttgcacaaga cgtactgtat ttaataactg gctgagaccc tccaaggcat 3507361 aatattcgca ctgtacagga atcacaacgg aatccgaggc agtaagggca ttaatcgtca 3507421 gcaagcccaa tgacggcgga caatcaatga taatataatc ataattttgc tttactgctt 3507481 caagcgctct cttcaatctc acttctcttg atattgtagg aaccagctcg atctcagccc 3507541 ctgcaagctg aatcgtcgca ggaatcacat ccaagttctc tactgtcgtt gctttaataa 3507601 tatctattac atctgcatca tctactaaaa tatcgtacac acactgctct acatcggctt 3507661 tttcaatccc taatccgctt gtcgcatttc cctgcggatc aatatctacc agcagaaccc 3507721 ttttccctat gtaagccaaa catgccccaa ggttgacaga cgtcgttgtt ttgccgaccc 3507781 cgcctttttg gttcgtaatt gctatgattt ttcccacgat gtcacctact ttcacatgaa 3507841 catgtactat cttgcttcta ttctatcaaa aaaagattaa agcgtttcat ttttttcatc 3507901 attttgttcc gaatcagaag ggaaataatt gaaaattcaa gcacgcttta tgctttctct 3507961 tataaattct gcaatttcta tgtttttttg acttaaaaaa ggaatttctt aaagaaaaaa 3508021 agaagaagtc acagtacaga acgtggaaac aggatggtga gaaaatggtt tatcaaacga 3508081 agagagatgt acccgttacg ctgatgattg tgtttctcat attactgata caagcagatg 3508141 ccattgttcc ttttgtgctg ggaaatatga gagtttccgg ctggatcatt tttattctgc 3508201 tgactctttt aaatggactc atcatttgga gctttattga cctaaaatat gtattgaagg 3508261 aacaccatct gatcattaaa gccggattga tcaaacatca aattccttat gaaaacatcg 3508321 ataaagtcgt tcaaaaaaag aaactatggt ccggttttcg tctgatcggc tctcgccatg 3508381 ccatcacaat atattatcag gggggatggg gacatgcagt aatttcaccg caaaaatctg 3508441 aagaatttat ccacaagctc aaagaaaaga attctaatat aataatattc actaaaagta 3508501 agtgattacc ttttgttaaa aatataaaaa gctctcctgc ttttcaggag agcttctatt 3508561 ttggtatgcg aatcgttaat tgaatatatt cttcaaattc ttcttcttcc gtattcaatt 3508621 ttacaccgct gtcttccacc attgatagtg actggcgaat cgtgttcatc gcaattcttg 3508681 tatctctgct gaatgctttg cgtctcggct ttggctttct ctggccttgc tccagcattt 3508741 tcaccacgcg gtcttctgtc tgctttacat ttaaactttt ctcaataatc tctgtgagca 3508801 gtgtgacttg gagctcaggc tgtttcagcg gaatcagtgc tctggcatgg cgctcggtga 3508861 ttttcttctc cataatcgcc tcttggaccg gctgaggcag ctttaataac cgaagcttat 3508921 tcgcgattgt agactgccct tttcctaagc gctgtgcgag tgcctcctgt gttaaatcat 3508981 gcagctcaag cagcctagca taagcatgcg cttcctcaat agaagacagt tcttcccgct 3509041 gcaagttttc gattaacgcc acagaagcgg tttccgtgtc ggaaaaatcc ttaataattg 3509101 ccggaatctt ttcccactca agcgattgca ccgctctcca gcgtctttca cctgcaatga 3509161 gttcgtattg gccttcttct tctgtatgcc taacaacaat cggctgaata atgccgtgtg 3509221 tatgaatggt cattgctaac tctttgattt tttcatctga gaaaatggtg cgtggctgaa 3509281 aacggttggg aacgatagca tttaccggta tttccagaat ctcttctttg tttgtatcat 3509341 gttcagcaat ctccggctcc tgttccttct caccaagccc gaagaaacga gagaatgaat 3509401 gcttcatgta cctacaccac ctttaaaaac tgccattttt ataattctat tttctcatgg 3509461 tttttcctgc tgtacatcca tcaattttga tgaaaatatg atggtattgt catatcaggc 3509521 tgtctaaatt acccttcaat tggcgattta ttaggagttc ccggttttct tggatacttc 3509581 ttaggtgtat tttttatttt gcgtatcacc ataatattac gatcgctttc ttcaataggc 3509641 agcttaaaag aatggatatt ctcaagttct cctccaagcg tcgtgattgc ttttttgcct 3509701 gcattcagtt cttcttcagc tgatgcggct tttaaagcaa caaataaacc gtttttcttc 3509761 accagaggca agcaaagctc actcaaaaca gataatctcg caactgcgcg cgccgtcaca 3509821 atatcatagc tttcacgcac gtctttccgt tgcccgaacg tttcagctct gtcatggcag 3509881 aatgttgtat tctccaattg caaagcttca gacaactttt ctaaaaacgt aatccgtttg 3509941 tttagtgaat ccacgattgt gacatggagg tgcggaaagc atatttttat cggcagactt 3510001 ggaaaacccg ctcccgctcc aacatcacaa atcgtgttca cctgattgaa gtcgacataa 3510061 aaagcagctg taatggaatc ataaaaatgc tttaaataca cttctttttt ctctgttatt 3510121 gaagtcagat tgattttttc gttccattca accagcatgt cgtaatacag ctcaaattgc 3510181 tccagctgac ggggagaaag ggagatccct ttttccgcca aaccagaagt gaattcttca 3510241 atattcatgc cgtcatcctt tctactcggc tatcttcgca atgcgtccct gctctaaata 3510301 caccaataga attgaaatgt ccgccgggtt tacaccggaa atgcgggaag cctgggcaac 3510361 agacaaaggc cgtacatttt tcagtttttg acgcgcctcg gtcgcaatcc ccttaattgc 3510421 gtcataatca attcggtctg gaattttttt attttccatc ttcttcagtt tttccacttg 3510481 ctgaagagat ttttcaatat atccttcata tttcacttgg atttctactt gttctgccac 3510541 gtcttgagga accggcactt ctggcggcgc cagttttgtg actgtttcat agttcatttc 3510601 aggacgtttc atcaagtctg tgccgcgaac tccatctttc aattcgcttc cgccaagaga 3510661 acggatatat tcttgatttt ccggagacgg cttgataatt acagaatgaa gacgtttttt 3510721 ctccgcctcg atcgccgctt ttttcttctc aaaagccgca tagcgctcat cagaaatcaa 3510781 tccaatgcga tgtccgattt ctgtcagacg caaatcagca ttgtcatggc gaagcagcaa 3510841 tctgtattcc gcacgtgatg tcaaaagacg atatggctca ttggtacctt ttgtcacaag 3510901 gtcatcaatc agaacaccaa tataggcgtc agaacggctt agaattactt cttcttttcc 3510961 aagcgctttt cgtcctgcat tgattcccgc cataatccct tgtcccgcag cttcttcata 3511021 accggatgtt ccgttaattt ggcctgcagt ataaaggttt gtgatttttt tggtttcaag 3511081 tgtcggccat agctgtgtcg gtacgattgc atcatactcg atcgcatagc cggctctcat 3511141 catttgcacg ttttcaagtc caggaatcgt tgcaagcatt ctttgctgta cgtcttctgg 3511201 aagacttgta gataaacctt ggacatagac ttcctgtgta tttctgcctt ccggctcaag 3511261 gaagatttgg tgacgcggtt tatcattaaa acggacaact ttgtcttcaa tggatgggca 3511321 gtatcttggg cccgtacctt tgatcatacc ggaatacatc ggtgaacggt gcaggttgct 3511381 gtcaataatc tcatgtgtct cagggcttgt atatgtcagc cagcaaggga gctgatctgt 3511441 gatatattcc actgtttcat atgagaaagc gcgaggcaca tcgtcaccag gctgaatttc 3511501 cgttttgctg taatcaatcg tgtcgctttt aacgcgaggc ggcgtacctg ttttaaaacg 3511561 aacaaggtca aaaccgagtt cctccaaatg ctcagaaagc ttaatagaag gctgctggtt 3511621 attcgggccg cttgagtaag acagatcgcc aagaatgata cgtcctctta aatatgtccc 3511681 tgtcgtcatg acaactgctt tcgcacgata atgtgcgcct gtttgtgtaa taacgcctcg 3511741 gcattcgccg tcttcaacga tcagccgctc cacaattcct tgcagcaatg ttaagtttgg 3511801 ttctttttca agcgtatttt tcatttcgtg ctgatattgg aatttgtctg cttgcgcacg 3511861 caatgcacga accgcaggac cttttcctgt attcagcatt ctcatttgaa tatgtgtttt 3511921 atcgatgttt cttcccattt ctccgccgag cgcgtcaatt tcgcggacga caatcccttt 3511981 tgcggggccg ccgacagacg gattacatgg cataaatgca accatatcta ggttgatggt 3512041 caagacaagc gttttggcgc cttggcgtgc agatgcgagg gcagcctcaa caccggcatg 3512101 cccggcgcca atcacaatca catcgtattg gcctgcttca taccccatga ttctagttcc 3512161 tcctttaatt attttcctaa acagaattga gaaaagagct gatcaattaa gctttcgtgg 3512221 acagaatctc caatgatttc ccctaaaagc tcccagcatc ttgtaaggtc aatttgcacc 3512281 atgtcgatcg ggacatcctg ttcgatgccg ctaagcgcat cttcaatggc gcgttttgct 3512341 tgctgtaaaa tagtgatgtg acgtgtgttg ctgacataag tcagatcacc gctttcaatg 3512401 gcacccgtgt agaacagtga ttgaatcgct tcttccagat cattgatgcc ttcctctttt 3512461 aaaagagatg tcgtaacaac tggacgtcca ttggcaagct cacggacacg ttcagtgtca 3512521 atcttcggct caaggtcagt cttattcaaa atcacgataa catccatgcc ctcaacggct 3512581 tcaaaaagct tcacgtcttc ttcagaaagc tcttcactat aattaagcac aagtaaaatc 3512641 aggtccgctt cctttaggac ctggcgagaa cgttcaacac cgattcgctc aacaatatcc 3512701 tctgtttcac gaatacctgc tgtatcaacc agacgaagcg gaacgcccct tacattcacg 3512761 tattcctcaa tcacatcccg tgtcgttccg ggaatatcgg ttacaatggc ttttgcctca 3512821 tgaacgaggc tgttcagaag agatgatttt cctacgtttg gccggccgat aatgacggta 3512881 gaaagacctt cacgcaagat ttttccttgc tcagaagtcc tcagcagcgt ctcaatttcc 3512941 tttttcacgg cggttgcctt ttcgactaaa atctgatgcg tcatttcctc tacatcatca 3513001 tactccggat aatcaatatt cacctcaaca tgggccagtg tttctaaaat ctcactgcgc 3513061 aaacggcgca ccaaagcaga aagacgccct tccatttgat tcatagcaac gttcattgcc 3513121 cggtccgttt tcgctctgat taagtccata accgcttccg cctgtgaaag atcgattcgg 3513181 ccgtttaaaa acgcacgttt cgtaaattca ccaggctctg ccagtctcgc tccctctctc 3513241 aatgcaagct gaagcacttg gttcacagtc acaattcccc cgtgacagtt aatctcgatg 3513301 acatcttctc gtgtaaaagt tctcggcgct tttaacactg ataccattac ttcctcaacg 3513361 acacgatccg aaggtctgtc tacgatatga ccataatgaa tcgtatgtga ttcgaccgag 3513421 ctgagtgttt tccccttcgg tcccttataa attttatctg cgatttgaat ggcttctggt 3513481 ccgctcaacc gtacaatcgc aatcgcgcct tctcccatcg gtgtggaaat tgccgcaatt 3513541 gtatccatgt tgttcacctc tctttactta tacttcatct atataaaaaa atttttatta 3513601 tgccaaaact aaaagataac atagtttggt tcgaagtgga agatttgtta tccacagaaa 3513661 tagaaattcg tcccttatta ctttaactta tccacatgtg aataacaatt aattttattt 3513721 cctgaacttc ctttttatca acaggataca cctaaaaaga aaaaacttaa acggcaaaac 3513781 cttgatatta ctaggaaaag tagatttttc ggatacaaaa aaaccgaaat ccaattttta 3513841 tcggacttcg gttttatgct atcttttatg ggaaataacg agatgacgat tttcgccttc 3513901 acccattgaa tatgttttga tctggtggtt tgcatatcca gaaagagtat cgtgaataat 3513961 ttttctttcg ctggacggca tgggctcaag ctggatggat tttttcgttt tcaaaacctg 3514021 gtcagcaagc ttgatggcca gctggctcag tgtttctttt cttttcaaac gatagttttc 3514081 tgcatccacc gtcacatttt tatattggcc tggataacgg ttaagggcaa gctgtgtcaa 3514141 agtttcaagg gcgtttaaag tttgtcctct tttcccaatc aacaatgctg ccttttcacc 3514201 tgttatatga tatctcactg tctttttgct ttcttgaaca gtcacatcag acttcccggc 3514261 aatggcttcg gcaatcgttt gaagatataa cttcgcttgc tgaatcggat caatcttttc 3514321 aaccagcttt acgatcgcag gctttttacc gaaaataccg agaaaccctt tgtttccctc 3514381 ttcaataaca gtaatttcta ccttatcctt cgttaatccc aactcttgca atccggactg 3514441 tactgcttca tcgacatttc gccctgcagc agtcacattc ctcacttttt ctttcctccg 3514501 gctttttgcg gctcaggatt ttttttaata tcaggtcctt taatgaggaa agtttgcgca 3514561 atcataaaca agttaccaac tacccaataa agagaaagag ccgccgggaa gttgatcgca 3514621 aatacgataa tcataattgg cataatccaa agcatcatcg ccatttgcgg attttgctgc 3514681 gcattgccag ccatcatcag tttttgctga acaaatgtag cgacaccggc aacgatagga 3514741 agaatatagt aaggatcttt ttctcctaag tcaaaccata agaagctatg ctctgaaatc 3514801 gcctgggttc tcatgatcgc atgatagaat ccaattaaaa tcggcatctg gatcaaaatc 3514861 gggaaacatc ccgccaatgg attgacacca tgcttttgga ataaagccat tgtttcctgt 3514921 tgaagctttt gctgcgtttt ttgatccttt gagctgtatt tttctttaag cttttgcatt 3514981 tccggctgta aagcctgcat cgctttcgaa cttctcagct gcttaatcat cagcggtaaa 3515041 attaataaac gaattaaaat ggtaactaga ataattgaaa gcccgtagtt atctcccgtc 3515101 aatttcgcta catacgtaat gagctcagac aatggatata ctacgtactt gtcccagaaa 3515161 tgcggactat ctgcagtgat cggctctttc acactcgagc atccagccaa aagcatgaat 3515221 acgccaacca tacttaatag caaccctatt ctccttttca acaacatttc ctcctataat 3515281 taatctttac actcttttat tgcaaagcat acttgtatgt attttagcat ctttcagttt 3515341 taaatggtgt ctttttctga tcaaccagaa aggaagcgct tttaaaagtt gtaagaaagc 3515401 agtggtgatg cctactttga cgaagatttc ttatataatg aagactttct gaatagatgc 3515461 tgcagacttt ttttcgtttc ctcatatgtc agctggctcg ccggttttct ggcaataatg 3515521 atgtaatcct tttccttcag tctctctttc tcttcaagaa aggcctgccg aatcaaacgt 3515581 ttgatccgat ttcgcatcac agcattgcca atttttttgc tgacggaaag cccgacacgc 3515641 agttcatcat tttcaggctg atcaagcgta tataagacaa actggcggtt tgcaactgat 3515701 gtcccatgtt taaacacttt ttgaaaatct tcatttttct ttaaacgatt tcgcttcttc 3515761 aaatgactca ctccgatact ggctggcaga aacttttaaa atttattatg aacatgagat 3515821 gcatctgaac caggaagcat gccccggttc attacgcatc acatctatct tttcccataa 3515881 cgtgaaaaaa gaccactgac attattcagt ggcctaagct gataatactt ttctgccttt 3515941 gcggcgacgg cgtgctaaaa ctagacgacc gttttttgaa ctcatacggc ttctgaagcc 3516001 atgaactttg ctgcgtttac ggttattcgg ttggaatgtt cttttcattt atgacacctc 3516061 cctcgaggaa tagctgttaa agacagtctt acttattata tttgcgttac ctattcattg 3516121 tcaacttcac tagtgctttt atttcttgca accataatag gataccatac cttttcaact 3516181 ttcgaaacct tattttttag attccttaat tttacggaaa aaagacaaat tcaaacaatt 3516241 tgcccctaaa atcacgcatg tggatatctt tttcggcttt ttttagtatc cacagaggtt 3516301 atcgacaaca ttttcacatt accaacccct gtggacaagg ttttttcaac aggttgtccg 3516361 ctttgtggat aagattgtga caaccattgc aagctctcgt ttattttggt attatatttg 3516421 tgttttaact cttgattact aatcctacct ttcctcttta tccacaaagt gtggataagt 3516481 tgtggattga tttcacacag cttgtgtaga aggttgtcca caagttgtga aatttgtcga 3516541 aaagctattt atctactata ttatatgttt tcaacattta atgtgtacga atggtaagcg 3516601 ccatttgctc tttttttgtg ttctataaca gagaaagacg ccattttcta agaaaaggag 3516661 ggacgtgccg gaag //